PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30905005-8	2019	Finally, in primary hippocampal cultures, repeated treatment with corticosterone led to decreased AMPAR-mediated Ca2+ influx, which was restored by PRL treatment.	Corticosterone	66-80	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	98-103
30905005-8	2019	Finally, in primary hippocampal cultures, repeated treatment with corticosterone led to decreased AMPAR-mediated Ca2+ influx, which was restored by PRL treatment.	Corticosterone	66-80	carbonic anhydrase 2	Mus musculus	113-116
31501614-4	2019	Stress elevated plasma corticosterone and upregulated the expression of glucocorticoid-inducible factor Tsc22d3, which blocked type I interferon (IFN) responses in dendritic cell (DC) and IFN-gamma+ T cell activation.	Corticosterone	23-37	TSC22 domain family, member 3	Mus musculus	104-111
31501614-4	2019	Stress elevated plasma corticosterone and upregulated the expression of glucocorticoid-inducible factor Tsc22d3, which blocked type I interferon (IFN) responses in dendritic cell (DC) and IFN-gamma+ T cell activation.	Corticosterone	23-37	interferon gamma	Mus musculus	188-197
30939596-6	2019	Grm2-/- mice were also resilient to developing corticosterone (CORT)-induced escape deficits and chronic social defeat stress-induced anhedonia.	Corticosterone	47-61	glutamate receptor, metabotropic 2	Mus musculus	0-4
30939596-6	2019	Grm2-/- mice were also resilient to developing corticosterone (CORT)-induced escape deficits and chronic social defeat stress-induced anhedonia.	Corticosterone	63-67	glutamate receptor, metabotropic 2	Mus musculus	0-4
31153932-0	2019	Oleanolic acid decreases SGK1 in the hippocampus in corticosterone-induced mice.	Corticosterone	52-66	serum/glucocorticoid regulated kinase 1	Mus musculus	25-29
31153932-2	2019	Considering that serine/threonine-protein kinase 1 (SGK1) is involved in stress response, the present study aimed to evaluate the involvement of SGK1 in the antidepressant-like effects of oleanolic acid in depression-like mice induced by long term corticosterone (CORT) injection.	Corticosterone	248-262	serum/glucocorticoid regulated kinase 1	Mus musculus	52-56
31153932-2	2019	Considering that serine/threonine-protein kinase 1 (SGK1) is involved in stress response, the present study aimed to evaluate the involvement of SGK1 in the antidepressant-like effects of oleanolic acid in depression-like mice induced by long term corticosterone (CORT) injection.	Corticosterone	264-268	serum/glucocorticoid regulated kinase 1	Mus musculus	52-56
31438781-1	2021	ABSTRACT Emotional stress, through elevating corticosterone (CORT) levels may reduce feeding in rodents however when offered palatable food, stressed animals ingest more food compared to non-stressed controls.	Corticosterone	45-59	cortistatin	Rattus norvegicus	61-65
31420008-4	2019	METHODS: Wild type (WT) and 11beta-HSD1 knockout (KO) mice were treated with corticosterone (100 mug/ml, 0.66% ethanol) or vehicle (0.66% ethanol) in drinking water over 4 weeks (six animals per group).	Corticosterone	77-91	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	28-39
31420008-10	2019	In contrast, 11beta-HSD1 KO mice receiving corticosterone demonstrated almost complete protection from trabecular bone loss, with partial protection from the decrease in osteoblast numbers and markers of bone formation relative to WT counterparts receiving corticosterone.	Corticosterone	43-57	RNA, U1 small nuclear 1	Homo sapiens	13-24
31467944-0	2019	Cyclooxygenase-2 inhibition reduces anxiety-like behavior and normalizes enhanced amygdala glutamatergic transmission following chronic oral corticosterone treatment.	Corticosterone	141-155	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
31233407-4	2019	Major hormonal responses to surgery, as indicated by changes in plasma adrenaline, noradrenaline, glucagon, aldosterone, corticosterone, 11-deoxycorticosterone, and 11-deoxycortisol levels, in the insulin/glucagon molar ratio, and in blood glucose, lactate, and pyruvate concentrations were significantly greater in the nonfentanyl than in the fentanyl group.	Corticosterone	121-135	insulin	Homo sapiens	197-204
31078691-9	2019	In addition, exposure of primary microglia to CORT also recapitulated the effects of stress on CD200R1 suggesting that CORT acts directly on microglia to reduce expression of CD200R1.	Corticosterone	46-50	CD200 receptor 1	Homo sapiens	95-102
31078691-9	2019	In addition, exposure of primary microglia to CORT also recapitulated the effects of stress on CD200R1 suggesting that CORT acts directly on microglia to reduce expression of CD200R1.	Corticosterone	46-50	CD200 receptor 1	Homo sapiens	175-182
31078691-9	2019	In addition, exposure of primary microglia to CORT also recapitulated the effects of stress on CD200R1 suggesting that CORT acts directly on microglia to reduce expression of CD200R1.	Corticosterone	119-123	CD200 receptor 1	Homo sapiens	95-102
31078691-9	2019	In addition, exposure of primary microglia to CORT also recapitulated the effects of stress on CD200R1 suggesting that CORT acts directly on microglia to reduce expression of CD200R1.	Corticosterone	119-123	CD200 receptor 1	Homo sapiens	175-182
31098671-14	2019	In white adipose tissue, androgens were required for induction of the glucocorticoid target gene Gilz (also known as Tsc22d3) by corticosterone.	Corticosterone	129-143	TSC22 domain family, member 3	Mus musculus	97-101
31108170-8	2019	In vitro treatment with CS also potently and selectively upregulated TIGIT, but not CTLA-4 or LAG-3, on mouse iNKT and MAIT hybridomas.	Corticosterone	24-26	cytotoxic T-lymphocyte-associated protein 4	Mus musculus	84-90
31098671-14	2019	In white adipose tissue, androgens were required for induction of the glucocorticoid target gene Gilz (also known as Tsc22d3) by corticosterone.	Corticosterone	129-143	TSC22 domain family, member 3	Mus musculus	117-124
31423223-0	2019	Corticosterone inhibits the expression of cannabinoid receptor-1 and cannabinoid receptor agonist-induced decrease in cell viability in glioblastoma cells.	Corticosterone	0-14	cannabinoid receptor 1	Homo sapiens	42-89
31103492-0	2019	d-Limonene protects PC12 cells against corticosterone-induced neurotoxicity by activating the AMPK pathway.	Corticosterone	39-53	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	94-98
31103492-3	2019	PC12 cells were treated with corticosterone with or without d-limonene for 24 h. Western blots were performed to measure activation of AMPK pathway members [Silent mating type information regulation 2 homolog-1 (SIRT1), AMPKalpha, and nuclear factor (NFkappaB)], reactive oxygen species, inflammatory cytokines, and markers of apoptosis.	Corticosterone	29-43	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	135-139
31264676-5	2019	GTD reversed the LPS-induced cytokine increase of TNF-alpha, IL-6, and corticosterone (CORT) in mice plasma and hippocampus.	Corticosterone	71-85	cortistatin	Mus musculus	87-91
30908701-0	2019	Undercarboxylated Osteocalcin Improves Insulin-Stimulated Glucose Uptake in Muscles of Corticosterone-Treated Mice.	Corticosterone	87-101	bone gamma-carboxyglutamate protein 2	Mus musculus	18-29
30908701-0	2019	Undercarboxylated Osteocalcin Improves Insulin-Stimulated Glucose Uptake in Muscles of Corticosterone-Treated Mice.	Corticosterone	87-101	insulin	Homo sapiens	39-46
30908701-7	2019	CS administration reduced both serum osteocalcin and ucOC levels, whole-body insulin sensitivity, and muscle ISGU in EDL.	Corticosterone	0-2	bone gamma-carboxyglutamate protein 2	Mus musculus	37-48
30908701-7	2019	CS administration reduced both serum osteocalcin and ucOC levels, whole-body insulin sensitivity, and muscle ISGU in EDL.	Corticosterone	0-2	insulin	Homo sapiens	77-84
30908701-10	2019	In CS-affected soleus muscle, ucOC enhanced insulin action on p-mammalian target of rapamycin (mTOR)Ser2481 , the p-mTORSer2481 /tmTOR ratio, p-Akt substrate of 160kD (AS160)Thr642 , and p-protein kinase C (PKC) (pan)Thr410 , which correlated with ISGU.	Corticosterone	3-5	insulin	Homo sapiens	44-51
30908701-12	2019	ucOC exerts direct insulin-sensitizing effects on CS-affected mouse muscle, likely through an enhancement in activity of key proteins involved in both insulin and ucOC signaling pathways.	Corticosterone	50-52	insulin	Homo sapiens	19-26
30908701-12	2019	ucOC exerts direct insulin-sensitizing effects on CS-affected mouse muscle, likely through an enhancement in activity of key proteins involved in both insulin and ucOC signaling pathways.	Corticosterone	50-52	insulin	Homo sapiens	151-158
30771372-0	2019	Corticosterone mediated functional and structural plasticity in corticotropin-releasing hormone neurons.	Corticosterone	0-14	corticotropin releasing hormone	Homo sapiens	64-95
30771372-5	2019	To address this, we determined the structural and functional changes in CRH neurons in the paraventricular nucleus of the hypothalamus following 14 days of corticosterone treatment.	Corticosterone	156-170	corticotropin releasing hormone	Homo sapiens	72-75
31423223-6	2019	Corticosterone decreased the mRNA and protein expressions of cyclooxygenase-2.	Corticosterone	0-14	prostaglandin-endoperoxide synthase 2	Homo sapiens	61-77
31423223-7	2019	Of note, although endocannabinoids decreased cell viability, corticosterone inhibited the cannabinoid receptor agonist-induced decrease in cell viability by downregulating the mRNA and protein expressions of cannabinoid receptor 1 (CB1) in glioblastoma cells.	Corticosterone	61-75	cannabinoid receptor 1	Homo sapiens	208-230
31423223-7	2019	Of note, although endocannabinoids decreased cell viability, corticosterone inhibited the cannabinoid receptor agonist-induced decrease in cell viability by downregulating the mRNA and protein expressions of cannabinoid receptor 1 (CB1) in glioblastoma cells.	Corticosterone	61-75	cannabinoid receptor 1	Homo sapiens	232-235
31423223-8	2019	These results suggest that corticosteroids modify the endocannabinoid system in glioblastoma cells, and a reduction in the beneficial anti-tumor effects of endocannabinoids through downregulation of the CB1 receptor by corticosterone may promote the malignant phenotype of glioblastoma.	Corticosterone	219-233	cannabinoid receptor 1	Homo sapiens	203-206
31085279-8	2019	Both ERs oppose hypoglycemic hyperglucagonemia, while ERbeta contributes to reduced corticosterone output.	Corticosterone	84-98	estrogen receptor 2	Rattus norvegicus	54-60
30789221-4	2019	In the GAA-free group, a 3-h transport increased the broiler live weight loss, elevated the plasma corticosterone concentration, decreased the plasma glucose concentration, muscle concentrations of ATP, creatine and energy charge value, increased the muscle AMP concentration and AMP/ATP ratio, and accelerated glycolysis metabolism, which resulted in inferior meat quality (lower pH and higher drip loss, P < 0.05).	Corticosterone	99-113	alpha glucosidase	Homo sapiens	7-10
31026437-5	2019	We found that 100 muM corticosterone induced PDE2A, PDE3B, PDE4A, PDE4D, PDE10 and PDE11 expression in HT-22 cells, which results in significant cell lesion.	Corticosterone	22-36	phosphodiesterase 2A, cGMP-stimulated	Mus musculus	45-50
31146010-0	2019	Overexpression of SIRT1 Inhibits Corticosterone-Induced Autophagy.	Corticosterone	33-47	sirtuin 1	Homo sapiens	18-23
31026437-5	2019	We found that 100 muM corticosterone induced PDE2A, PDE3B, PDE4A, PDE4D, PDE10 and PDE11 expression in HT-22 cells, which results in significant cell lesion.	Corticosterone	22-36	phosphodiesterase 3B, cGMP-inhibited	Mus musculus	52-57
31026437-5	2019	We found that 100 muM corticosterone induced PDE2A, PDE3B, PDE4A, PDE4D, PDE10 and PDE11 expression in HT-22 cells, which results in significant cell lesion.	Corticosterone	22-36	phosphodiesterase 4A, cAMP specific	Mus musculus	59-64
31146010-5	2019	By utilizing a cellular stress model of exposing cells to corticosterone, our study found that there were a dose-dependent decrease in SIRT1 and an increase in LC3B II/I expressions with increasing concentrations of corticosterone.	Corticosterone	58-72	sirtuin 1	Homo sapiens	135-140
31146010-5	2019	By utilizing a cellular stress model of exposing cells to corticosterone, our study found that there were a dose-dependent decrease in SIRT1 and an increase in LC3B II/I expressions with increasing concentrations of corticosterone.	Corticosterone	216-230	sirtuin 1	Homo sapiens	135-140
31026437-5	2019	We found that 100 muM corticosterone induced PDE2A, PDE3B, PDE4A, PDE4D, PDE10 and PDE11 expression in HT-22 cells, which results in significant cell lesion.	Corticosterone	22-36	phosphodiesterase 4D, cAMP specific	Mus musculus	66-71
31146010-6	2019	In combination with SIRT1 overexpression and knockdown plasmids, the regulation of SIRT1 expression in vitro demonstrated that SIRT can inhibit corticosterone-induced autophagy and enhance cell apoptosis.	Corticosterone	144-158	sirtuin 1	Homo sapiens	83-88
31163207-9	2019	Prolonged exposure to CORT or DEX induced dose-dependent reduction of the myelination index, and of immunostaining for MBP and Cx43 in SC and CC myelination cultures, which was prevented by mifepristone.	Corticosterone	22-26	myelin basic protein	Rattus norvegicus	119-122
31026437-9	2019	Resveratrol prevented corticosterone-induced reduction in cAMP, pVASP(s157), pCREB, and BDNF levels, indicating that cAMP signaling is involved in resveratrol-induced neuroprotective effects.	Corticosterone	22-36	brain derived neurotrophic factor	Mus musculus	88-92
31163207-9	2019	Prolonged exposure to CORT or DEX induced dose-dependent reduction of the myelination index, and of immunostaining for MBP and Cx43 in SC and CC myelination cultures, which was prevented by mifepristone.	Corticosterone	22-26	gap junction protein, alpha 1	Rattus norvegicus	127-131
31299063-5	2019	Sdc1+/- mice have a reduced body weight although they show increased leptin and decreased corticosterone levels.	Corticosterone	90-104	syndecan 1	Mus musculus	0-4
31213533-7	2019	Increased corticosterone then activates AgRP neurons to fully increase hunger.	Corticosterone	10-24	agouti related neuropeptide	Homo sapiens	40-44
31095108-1	2019	We previously showed that an acute stress-induced an early corticosterone rise in the dorsal hippocampus (dHPC) and a delayed one in the ventral hippocampus (vHPC).	Corticosterone	59-73	Hairless	Drosophila melanogaster	106-110
31095108-4	2019	In nonstress condition, we showed that the dHPC lesion induced a significant increase of corticosterone both in plasma and in the vHPC.	Corticosterone	89-103	Hairless	Drosophila melanogaster	43-47
31095108-5	2019	In addition, an acute stress (electric footshocks) induced a faster and more sustained corticosterone rise in the vHPC of dHPC-lesioned animals, as compared to sham-operated ones.	Corticosterone	87-101	Hairless	Drosophila melanogaster	122-126
31095108-6	2019	This study provides new found evidence to the effect that the dHPC lesion alters the time-course evolution of corticosterone rise within the vHPC after stress.	Corticosterone	110-124	Hairless	Drosophila melanogaster	62-66
30990748-9	2019	We generated mice with an Hsd11b2 placental-specific disruption (Hsd11b2PKO) and observed moderately elevated corticosterone levels in offspring, along with increased body weight.	Corticosterone	110-124	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	26-33
31022597-2	2019	The present study aimed to explore the molecular mechanisms underlying the neuroprotective effects of PBP in corticosterone (CORT)-induced rat adrenal pheochromocytoma PC12 cells.	Corticosterone	109-123	cortistatin	Rattus norvegicus	125-129
30794767-1	2019	Corticosterone (CORT) has long been shown to modulate 5-HT system, and to alter hippocampal functions in various physiological and pathological conditions.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
31166572-10	2019	The decrease in corticosterone in ALD1611-treated pups was associated with decreases in baseline and hypoxia- and ACTH-stimulated adrenal Ldlr, Mrap, and Star mRNA expression at all ages.	Corticosterone	16-30	low density lipoprotein receptor	Rattus norvegicus	138-142
31308626-3	2019	The purpose of this study was to investigate the influence of ginsenoside Rb1 on plasma corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels and hippocampal brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) levels in rats subjected to acute immobilization stress.	Corticosterone	88-102	RB transcriptional corepressor 1	Rattus norvegicus	74-77
31308626-10	2019	Conclusion: The results from this study demonstrate that Rb1 pretreatment reverses the decreases in hippocampal BDNF/TrkB and increases the plasma levels of CORT and ACTH, indicating a potential neuroprotective effect of Rb1 against acute stress.	Corticosterone	157-161	RB transcriptional corepressor 1	Rattus norvegicus	57-60
31166572-10	2019	The decrease in corticosterone in ALD1611-treated pups was associated with decreases in baseline and hypoxia- and ACTH-stimulated adrenal Ldlr, Mrap, and Star mRNA expression at all ages.	Corticosterone	16-30	melanocortin 2 receptor accessory protein	Rattus norvegicus	144-148
31141788-9	2019	Intriguingly, when we subjected the offspring to 2 weeks of chronic stress to elevate the serum corticosterone concentration, the expression of Igf1 and testosterone synthesis were inhibited again in the PCE (120 mg/kg/day) group, accompanied by a decrease in the H3K14ac level in the Igf1 promoter region.	Corticosterone	96-110	insulin-like growth factor 1	Rattus norvegicus	144-148
30121625-12	2019	Finally, compared to WT mice, ethanol-fed Aldh2 -/- mice had higher levels of serum corticosterone, a well-known factor that inhibits aerobic glycolysis.	Corticosterone	84-98	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	42-47
30121625-13	2019	Blockade of corticosterone partially restored ConA-mediated hepatitis in ethanol-fed Aldh2 -/- mice.	Corticosterone	12-26	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	85-90
31370004-9	2019	Additionally, serum corticosterone levels were selectively elevated in GR-CKO mice with CR, suggesting the possibility of bone-hypothalamus-pituitary-adrenal crosstalk during metabolic stress.	Corticosterone	20-34	nuclear receptor subfamily 3, group C, member 1	Mus musculus	71-77
30771372-6	2019	We find that prolonged corticosterone elevation reduces CRH neuron intrinsic excitability as measured by summation of subthreshold postsynaptic depolarisations and spiking output.	Corticosterone	23-37	corticotropin releasing hormone	Homo sapiens	56-59
31141788-9	2019	Intriguingly, when we subjected the offspring to 2 weeks of chronic stress to elevate the serum corticosterone concentration, the expression of Igf1 and testosterone synthesis were inhibited again in the PCE (120 mg/kg/day) group, accompanied by a decrease in the H3K14ac level in the Igf1 promoter region.	Corticosterone	96-110	insulin-like growth factor 1	Rattus norvegicus	285-289
31141788-10	2019	In vitro, corticosterone (rather than caffeine) was proved to inhibit testosterone production in Leydig cells by altering the H3K14ac level and the expression of Igf1.	Corticosterone	10-24	insulin-like growth factor 1	Rattus norvegicus	162-166
30954817-9	2019	Furthermore, transcripts encoding proteins related to immune system regulation (irg1l, gilz) and fkbp5 were differentially expressed by corticosterone and betamethasone, while flumethasone caused only little effects, mainly alteration of the irg1l transcript.	Corticosterone	136-150	immunoresponsive gene 1, like	Danio rerio	80-85
30922853-8	2019	ZSXPT decreased Cort-induced ROS generation, increased MMP, and accelerated autophagy through the blockade of the mammalian target of rapamycin (mTOR) pathway.	Corticosterone	16-20	mechanistic target of rapamycin kinase	Homo sapiens	114-143
30922853-8	2019	ZSXPT decreased Cort-induced ROS generation, increased MMP, and accelerated autophagy through the blockade of the mammalian target of rapamycin (mTOR) pathway.	Corticosterone	16-20	mechanistic target of rapamycin kinase	Homo sapiens	145-149
30954817-9	2019	Furthermore, transcripts encoding proteins related to immune system regulation (irg1l, gilz) and fkbp5 were differentially expressed by corticosterone and betamethasone, while flumethasone caused only little effects, mainly alteration of the irg1l transcript.	Corticosterone	136-150	FKBP prolyl isomerase 5	Danio rerio	97-102
30954817-9	2019	Furthermore, transcripts encoding proteins related to immune system regulation (irg1l, gilz) and fkbp5 were differentially expressed by corticosterone and betamethasone, while flumethasone caused only little effects, mainly alteration of the irg1l transcript.	Corticosterone	136-150	immunoresponsive gene 1, like	Danio rerio	242-247
31673494-3	2019	Sedentary (S) and exercise (ET) groups were treated with corticosterone (CORT) followed by injection of DFP.	Corticosterone	57-71	cortistatin	Mus musculus	73-77
31197099-8	2019	In detail, corticosterone administration to organotypic mouse brainstem cultures significantly increases Tyrosine hydroxylase (TH) and Dopamine transporter (DAT), while Phenylethanolamine N-methyltransferase (PNMT) is not affected.	Corticosterone	11-25	tyrosine hydroxylase	Mus musculus	105-125
31197099-8	2019	In detail, corticosterone administration to organotypic mouse brainstem cultures significantly increases Tyrosine hydroxylase (TH) and Dopamine transporter (DAT), while Phenylethanolamine N-methyltransferase (PNMT) is not affected.	Corticosterone	11-25	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	135-155
31197099-8	2019	In detail, corticosterone administration to organotypic mouse brainstem cultures significantly increases Tyrosine hydroxylase (TH) and Dopamine transporter (DAT), while Phenylethanolamine N-methyltransferase (PNMT) is not affected.	Corticosterone	11-25	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	157-160
31197099-8	2019	In detail, corticosterone administration to organotypic mouse brainstem cultures significantly increases Tyrosine hydroxylase (TH) and Dopamine transporter (DAT), while Phenylethanolamine N-methyltransferase (PNMT) is not affected.	Corticosterone	11-25	phenylethanolamine-N-methyltransferase	Mus musculus	209-213
31197099-9	2019	On the other hand, Dopamine Beta-Hydroxylase (DBH) increases only after very high doses of corticosterone.	Corticosterone	91-105	dopamine beta hydroxylase	Mus musculus	19-44
31197099-9	2019	On the other hand, Dopamine Beta-Hydroxylase (DBH) increases only after very high doses of corticosterone.	Corticosterone	91-105	dopamine beta hydroxylase	Mus musculus	46-49
31185901-7	2019	Several of the corticosterone responsive genes are known to be involved in immune system response (LY-6E), oxidative stress (GSTM2 and TRX), and tissue repair (A2M and FX).	Corticosterone	15-29	lymphocyte antigen 6 family member E	Homo sapiens	99-104
31185901-7	2019	Several of the corticosterone responsive genes are known to be involved in immune system response (LY-6E), oxidative stress (GSTM2 and TRX), and tissue repair (A2M and FX).	Corticosterone	15-29	glutathione S-transferase mu 2	Homo sapiens	125-130
31185901-7	2019	Several of the corticosterone responsive genes are known to be involved in immune system response (LY-6E), oxidative stress (GSTM2 and TRX), and tissue repair (A2M and FX).	Corticosterone	15-29	thioredoxin	Homo sapiens	135-138
31185901-9	2019	Furthermore, the expression patterns of some genes (GSTM2, LY-6E, UMOD, ZNF593, CIRBP, HSP90) show interactive effects of temperature and corticosterone exposure, compared to each treatment alone.	Corticosterone	138-152	glutathione S-transferase mu 2	Homo sapiens	52-57
31185901-9	2019	Furthermore, the expression patterns of some genes (GSTM2, LY-6E, UMOD, ZNF593, CIRBP, HSP90) show interactive effects of temperature and corticosterone exposure, compared to each treatment alone.	Corticosterone	138-152	lymphocyte antigen 6 family member E	Homo sapiens	59-64
31185901-9	2019	Furthermore, the expression patterns of some genes (GSTM2, LY-6E, UMOD, ZNF593, CIRBP, HSP90) show interactive effects of temperature and corticosterone exposure, compared to each treatment alone.	Corticosterone	138-152	uromodulin	Homo sapiens	66-70
31185901-9	2019	Furthermore, the expression patterns of some genes (GSTM2, LY-6E, UMOD, ZNF593, CIRBP, HSP90) show interactive effects of temperature and corticosterone exposure, compared to each treatment alone.	Corticosterone	138-152	zinc finger protein 593	Homo sapiens	72-78
31185901-9	2019	Furthermore, the expression patterns of some genes (GSTM2, LY-6E, UMOD, ZNF593, CIRBP, HSP90) show interactive effects of temperature and corticosterone exposure, compared to each treatment alone.	Corticosterone	138-152	cold inducible RNA binding protein	Homo sapiens	80-85
31185901-9	2019	Furthermore, the expression patterns of some genes (GSTM2, LY-6E, UMOD, ZNF593, CIRBP, HSP90) show interactive effects of temperature and corticosterone exposure, compared to each treatment alone.	Corticosterone	138-152	heat shock protein 90 alpha family class A member 1	Homo sapiens	87-92
31174552-8	2019	Accordingly, we found that transgenic mice bearing the G2019S LRRK2 mutation had elevated basal corticosterone, along with diminished hippocampal 5-HT1A levels.	Corticosterone	96-110	leucine-rich repeat kinase 2	Mus musculus	62-67
30851317-0	2019	Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus.	Corticosterone	11-25	brain-derived neurotrophic factor	Rattus norvegicus	54-87
30851317-0	2019	Effects of corticosterone on the expression of mature brain-derived neurotrophic factor (mBDNF) and proBDNF in the hippocampal dentate gyrus.	Corticosterone	11-25	brain derived neurotrophic factor	Mus musculus	89-94
30857416-8	2019	Supporting this interpretation, VAChT mutants exhibited alterations in anxiety-like behavior and increased corticosterone levels after exposure to the MWM, suggesting altered stress response.	Corticosterone	107-121	solute carrier family 18 (vesicular monoamine), member 3	Mus musculus	32-37
30523668-8	2019	The mRNA for stress-related genes, brain-derived neurotrophic factor and tyrosine kinase-coupled receptor were also significantly reduced in the hippocampus of corticosterone-treated mice compared to that in control mice.	Corticosterone	160-174	brain derived neurotrophic factor	Mus musculus	35-68
31026055-14	2019	Corticosterone reduced placental mitochondrial content but increased protein expression of the autophagosome cargo protein p62.	Corticosterone	0-14	nucleoporin 62	Mus musculus	123-126
30922853-10	2019	CONCLUSIONS: Our in vitro and in vivo results indicate that the neuroprotective effect of ZSXPT against autophagy-induced damage and apoptosis occurs mainly by blocking the mTOR pathway in Cort-induced PC12 cells and in FD rats.	Corticosterone	189-193	mechanistic target of rapamycin kinase	Rattus norvegicus	173-177
30798401-4	2019	Plasma corticosterone (CORT) levels were measured in conditioned (SFC+) and unconditioned (SFC-) mice after exposure to non-social or social stimuli.	Corticosterone	7-21	cortistatin	Mus musculus	23-27
31029038-1	2019	Corticosterone (CORT), the main HPA-axis glucocorticoid hormone in rodents, is involved in the regulation of animal stress responses.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
30885650-12	2019	Therefore, we conclude that administration of estradiol in stress decreases corticosterone induced sensitivity mediated by an increased expression of ERalpha in brain, ovary and shell gland.	Corticosterone	76-90	estrogen receptor 1	Gallus gallus	150-157
30597251-11	2019	We further demonstrate that the increase of plasma corticosterone levels after incubation time is exaggerated in NPSR-deficient mice.	Corticosterone	51-65	neuropeptide S receptor 1	Mus musculus	113-117
28882088-4	2019	Methods: We conducted a protein expression analysis of the specific subunit of system xc- (xCT) in brain regions of the corticosterone mouse model, Flinders Sensitive Line rat model and post-mortem tissue of depressed patients.	Corticosterone	120-134	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	91-94
30735759-6	2019	PINK1 loss and corticosterone negatively and jointly affected AHN, leading to lower numbers of neural stem cells and newborn neurons in the dentate gyrus of corticosterone-treated PINK1-/- mice.	Corticosterone	15-29	PTEN induced putative kinase 1	Mus musculus	180-185
30735759-6	2019	PINK1 loss and corticosterone negatively and jointly affected AHN, leading to lower numbers of neural stem cells and newborn neurons in the dentate gyrus of corticosterone-treated PINK1-/- mice.	Corticosterone	157-171	PTEN induced putative kinase 1	Mus musculus	0-5
30735759-6	2019	PINK1 loss and corticosterone negatively and jointly affected AHN, leading to lower numbers of neural stem cells and newborn neurons in the dentate gyrus of corticosterone-treated PINK1-/- mice.	Corticosterone	157-171	PTEN induced putative kinase 1	Mus musculus	180-185
30735759-8	2019	However, lack of PINK1 sensitized mice to corticosterone-induced behavioral despair in the tail suspension test at a dose where wildtype mice were unaffected.	Corticosterone	42-56	PTEN induced putative kinase 1	Mus musculus	17-22
29424043-7	2019	beta-E -/- female mice also displayed elevated basal anxiety, plasma corticosterone and corticotropin-releasing hormone mRNA in the extended amygdala, and all of these were normalized by EtOH self-administration.	Corticosterone	69-83	pro-opiomelanocortin-alpha	Mus musculus	0-6
30117098-5	2019	The cascade is driven by mineralocorticoid receptor (MR) activation responding to endogenous corticosterone rather than aldosterone.	Corticosterone	93-107	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	25-51
30117098-5	2019	The cascade is driven by mineralocorticoid receptor (MR) activation responding to endogenous corticosterone rather than aldosterone.	Corticosterone	93-107	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	53-55
30794724-2	2019	A murine model of corticosterone treatment resulted in increased hypothalamic expression of the melanocortin antagonist AgRP in parallel with obesity and hyperglycemia.	Corticosterone	18-32	agouti related neuropeptide	Mus musculus	120-124
30794724-4	2019	Wild-type and Agrp-/- male mice were treated with corticosterone for 3 weeks.	Corticosterone	50-64	agouti related neuropeptide	Mus musculus	14-18
30794724-11	2019	Mice with Agrp deleted [using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, Agrp-/-] were partially protected against corticosterone-induced hyperphagia.	Corticosterone	145-159	agouti related neuropeptide	Mus musculus	10-14
30904544-12	2019	Corticosterone administration decreased BDNF levels and Riparin IV could reestablish them, indicating that its antidepressant effect may be related to ability to ameliorate hippocampal neurogenesis.	Corticosterone	0-14	brain derived neurotrophic factor	Mus musculus	40-44
30796905-1	2019	The microsomal enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) interconverts glucocorticoid receptor-inert cortisone (11-dehydrocorticosterone in rodents) to its receptor-active form cortisol (corticosterone in rodents).	Corticosterone	144-158	RNA, U1 small nuclear 1	Homo sapiens	4-77
30796905-1	2019	The microsomal enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) interconverts glucocorticoid receptor-inert cortisone (11-dehydrocorticosterone in rodents) to its receptor-active form cortisol (corticosterone in rodents).	Corticosterone	144-158	nuclear receptor subfamily 3 group C member 1	Homo sapiens	93-116
31057364-2	2019	Here, we show that a spexin-based galanin receptor type 2 agonist (SG2A) simultaneously normalized mood behaviors and body weight in corticosterone pellet-implanted (CORTI) mice, which are underweight and exhibit signs of anhedonia, increased anxiety, and depression.	Corticosterone	133-147	spexin hormone	Mus musculus	21-27
31057364-2	2019	Here, we show that a spexin-based galanin receptor type 2 agonist (SG2A) simultaneously normalized mood behaviors and body weight in corticosterone pellet-implanted (CORTI) mice, which are underweight and exhibit signs of anhedonia, increased anxiety, and depression.	Corticosterone	133-147	galanin receptor 2	Mus musculus	34-57
31057373-6	2019	Moreover, Alox5 -/- mice present increased caspase-1 expression and elevated levels of IL-1beta, IL-17 and PGE2 in the spleen, with increasing corticosterone levels in the frontal cortex but reducing systemic levels.	Corticosterone	143-157	arachidonate 5-lipoxygenase	Mus musculus	10-15
31057373-13	2019	Even so, taken together our results indicate that 5-LO activity is critical for the regulation of stress-induced symptoms, suggesting that the Alox5 -/- mouse could be a natural model of corticosterone-independent reduced reward sensitivity.	Corticosterone	187-201	arachidonate 5-lipoxygenase	Mus musculus	143-148
30979912-5	2019	Corticosterone (CS) treatment resulted in insulin resistance, abnormal fat accrual, loss of lean mass and suppression of serum osteocalcin levels in both genotypes.	Corticosterone	0-14	bone gamma-carboxyglutamate protein 2	Mus musculus	127-138
30979912-5	2019	Corticosterone (CS) treatment resulted in insulin resistance, abnormal fat accrual, loss of lean mass and suppression of serum osteocalcin levels in both genotypes.	Corticosterone	16-18	bone gamma-carboxyglutamate protein 2	Mus musculus	127-138
31008396-13	2019	The ACTH stimulation test revealed that the plasma corticosterone concentration of the heat-stressed low-protein mice was significantly lower than that of the heat-stressed controls.	Corticosterone	51-65	pro-opiomelanocortin-alpha	Mus musculus	4-8
30912177-8	2019	By contrast, 5alpha-reductase inhibition or an androgen receptor antagonist had little effect in adolescents and attenuated the age difference by increasing stress-induced corticosterone release in adults.	Corticosterone	172-186	androgen receptor	Rattus norvegicus	47-64
30776492-1	2019	Organic cation transporter 3 (OCT3) is a corticosterone-sensitive, low-affinity, high-capacity transporter.	Corticosterone	41-55	solute carrier family 22 member 3	Rattus norvegicus	0-28
30776492-1	2019	Organic cation transporter 3 (OCT3) is a corticosterone-sensitive, low-affinity, high-capacity transporter.	Corticosterone	41-55	solute carrier family 22 member 3	Rattus norvegicus	30-34
31110770-7	2019	The tested corticosterone EIA was the only assay able to monitor alterations in dGC concentrations following the handling event in P. edulis.	Corticosterone	11-25	gamma-glutamyl carboxylase	Drosophila melanogaster	80-83
31067456-3	2019	Contrary to previous suggestions, we show that only in mice housed at thermoneutrality (30 C) does corticosterone treatment reduce total BAT UCP1 protein.	Corticosterone	99-113	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	141-145
31067456-6	2019	In corticosterone-treated wild-type and UCP1 knockout mice housed at 30 C, obesity also develops to the same extent.	Corticosterone	3-17	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	40-44
31052489-3	2019	We hypothesized that combined neurodevelopmental exposure to both deltamethrin and corticosterone (CORT), the major stress hormone in rodents, would result in additive changes within the dopamine system.	Corticosterone	83-97	cortistatin	Homo sapiens	99-103
30794724-11	2019	Mice with Agrp deleted [using clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9, Agrp-/-] were partially protected against corticosterone-induced hyperphagia.	Corticosterone	145-159	agouti related neuropeptide	Mus musculus	103-107
30794724-12	2019	However, Agrp-/- mice still had corticosterone-induced increases in body weight and adiposity similar to those of the Agrp+/+ mice.	Corticosterone	32-46	agouti related neuropeptide	Mus musculus	9-13
30683681-0	2019	Chronic Suppression of Glucagon-Like Peptide-1 Receptor (GLP1R) mRNA Translation in the Rat Bed Nucleus of the Stria Terminalis Reduces Anxiety-Like Behavior and Stress-Induced Hypophagia, But Prolongs Stress-Induced Elevation of Plasma Corticosterone.	Corticosterone	237-251	glucagon-like peptide 1 receptor	Rattus norvegicus	23-55
30683681-0	2019	Chronic Suppression of Glucagon-Like Peptide-1 Receptor (GLP1R) mRNA Translation in the Rat Bed Nucleus of the Stria Terminalis Reduces Anxiety-Like Behavior and Stress-Induced Hypophagia, But Prolongs Stress-Induced Elevation of Plasma Corticosterone.	Corticosterone	237-251	glucagon-like peptide 1 receptor	Rattus norvegicus	57-62
30683681-2	2019	GLP1 administered centrally reduces food intake and increases anxiety-like behavior and plasma corticosterone (cort) levels in rats, whereas central GLP1R antagonism has opposite effects.	Corticosterone	95-109	glucagon	Rattus norvegicus	0-4
30683681-2	2019	GLP1 administered centrally reduces food intake and increases anxiety-like behavior and plasma corticosterone (cort) levels in rats, whereas central GLP1R antagonism has opposite effects.	Corticosterone	95-99	glucagon	Rattus norvegicus	0-4
31138987-4	2019	HT22 cells treated with the stress hormone glucocorticoid (GC; corticosterone) had reduced expression of Bdnf and Sirt1, whereas L-EV treatment reversed GC-induced decreased expression of Bdnf and Sirt1.	Corticosterone	63-77	brain derived neurotrophic factor	Mus musculus	105-109
30633988-7	2019	In contrast to our hypothesis that decreasing cholesterol efflux would increase the adrenal cholesterol pool and enhance glucocorticoid output, ABCG1 knockout mice as compared to wild-type mice exhibited a reduced ability to secrete corticosterone in response to an ACTH challenge (two-way ANOVA: P < 0.001 for genotype) or fasting stress.	Corticosterone	233-247	ATP binding cassette subfamily G member 1	Mus musculus	144-149
30776301-4	2019	Matrix metalloproteinase (MMP)-9 mRNA and its activity, COX2 mRNA levels, and prostaglandin E2 synthesis were increased, whereas type 1 collagen (COL1A1) mRNA levels were decreased in the fetal membranes of corticosterone-injected mice.	Corticosterone	207-221	matrix metallopeptidase 9	Mus musculus	0-32
30776301-4	2019	Matrix metalloproteinase (MMP)-9 mRNA and its activity, COX2 mRNA levels, and prostaglandin E2 synthesis were increased, whereas type 1 collagen (COL1A1) mRNA levels were decreased in the fetal membranes of corticosterone-injected mice.	Corticosterone	207-221	collagen, type I, alpha 1	Mus musculus	121-152
30817943-0	2019	Camellia euphlebia protects against corticosterone-induced apoptosis in differentiated PC12 cells by regulating the mitochondrial apoptotic pathway and PKA/CREB/BDNF signaling pathway.	Corticosterone	36-50	cAMP responsive element binding protein 1	Rattus norvegicus	156-160
30817943-0	2019	Camellia euphlebia protects against corticosterone-induced apoptosis in differentiated PC12 cells by regulating the mitochondrial apoptotic pathway and PKA/CREB/BDNF signaling pathway.	Corticosterone	36-50	brain-derived neurotrophic factor	Rattus norvegicus	161-165
31138987-4	2019	HT22 cells treated with the stress hormone glucocorticoid (GC; corticosterone) had reduced expression of Bdnf and Sirt1, whereas L-EV treatment reversed GC-induced decreased expression of Bdnf and Sirt1.	Corticosterone	63-77	sirtuin 1	Mus musculus	114-119
30468724-9	2019	Leptin treatment decreased NE release modestly but produced a robust reduction in corticosterone (CS) levels.	Corticosterone	82-96	leptin	Rattus norvegicus	0-6
30945498-6	2019	The expression of adenosine 5"-monophosphate (AMP)-activated protein kinase (AMPK) of PVN tissue was assayed by Western blot, and the contents of acetyl coenzyme A (Ac-CoA) and Na+-K+adenosine triphosphatase (Na+-K+-ATPase) in the PVN tissue, and corticosterone (CORT) in plasma were assayed by ELISA.	Corticosterone	247-261	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	77-81
30658246-2	2019	METHODS: In order to elucidate the pathogenic mechanisms underlying early life adversity-induced refractory depression in more detail, we administered corticosterone (CORT) to adolescent rats with or without prenatal ethanol exposure followed by an antidepressant or antipsychotic and examined alterations in depressive and social function behaviors and brain-derived neurotrophic factor (BDNF) levels in serum, the hippocampus, anterior cingulate cortex, and nucleus accumbens.	Corticosterone	151-165	cortistatin	Rattus norvegicus	167-171
30468724-9	2019	Leptin treatment decreased NE release modestly but produced a robust reduction in corticosterone (CS) levels.	Corticosterone	82-96	citrate synthase	Rattus norvegicus	98-100
30992737-0	2019	MicroRNA-25 Protects Smooth Muscle Cells against Corticosterone-Induced Apoptosis.	Corticosterone	49-63	microRNA 25	Mus musculus	0-11
30992737-8	2019	Results: VSMC apoptosis, caspase-3 activity, and Bax were increased by corticosterone, and cell death was paralleled by marked loss of miR-25.	Corticosterone	71-85	BCL2-associated X protein	Mus musculus	49-52
30992737-12	2019	Conclusions: MicroRNA-25 blocks corticosterone-induced VSMC apoptosis by targeting MOAP1 and the p70S6k pathway.	Corticosterone	32-46	microRNA 25	Mus musculus	13-24
30992737-12	2019	Conclusions: MicroRNA-25 blocks corticosterone-induced VSMC apoptosis by targeting MOAP1 and the p70S6k pathway.	Corticosterone	32-46	modulator of apoptosis 1	Mus musculus	83-88
30992737-12	2019	Conclusions: MicroRNA-25 blocks corticosterone-induced VSMC apoptosis by targeting MOAP1 and the p70S6k pathway.	Corticosterone	32-46	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	97-103
30392783-2	2019	It remains unknown how adolescent individuals would be affected by chronic exposure to corticosterone (the major stress hormone in rodents, CORT) at the doses that are usually not detrimental in adults.	Corticosterone	87-101	cortistatin	Rattus norvegicus	140-144
30682622-7	2019	Our data revealed that pregnenolone, progesterone, testosterone, DHEAS and corticosterone competitively inhibited transformation of MCB by Gstr1 with the calculated Ki values in the range 14-26 muM, implying that these hormones are physiological substrates of zebrafish Gstr1.	Corticosterone	75-89	glutathione S-transferase rho	Danio rerio	139-144
30682622-7	2019	Our data revealed that pregnenolone, progesterone, testosterone, DHEAS and corticosterone competitively inhibited transformation of MCB by Gstr1 with the calculated Ki values in the range 14-26 muM, implying that these hormones are physiological substrates of zebrafish Gstr1.	Corticosterone	75-89	glutathione S-transferase rho	Danio rerio	270-275
30821590-6	2019	In utero, when fetal rats were overexposed to corticosterone by PEE, the expression levels of testicular glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) were increased, while that of steroidogenic factor 1 (SF1) was decreased.	Corticosterone	46-60	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	105-128
30821590-6	2019	In utero, when fetal rats were overexposed to corticosterone by PEE, the expression levels of testicular glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) were increased, while that of steroidogenic factor 1 (SF1) was decreased.	Corticosterone	46-60	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	130-132
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	271-285	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	122-131
30821590-6	2019	In utero, when fetal rats were overexposed to corticosterone by PEE, the expression levels of testicular glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) were increased, while that of steroidogenic factor 1 (SF1) was decreased.	Corticosterone	46-60	histone deacetylase 2	Rattus norvegicus	138-159
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	271-285	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	133-136
30821590-6	2019	In utero, when fetal rats were overexposed to corticosterone by PEE, the expression levels of testicular glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) were increased, while that of steroidogenic factor 1 (SF1) was decreased.	Corticosterone	46-60	histone deacetylase 2	Rattus norvegicus	161-166
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	271-285	histone deacetylase 2	Rattus norvegicus	180-185
30821590-6	2019	In utero, when fetal rats were overexposed to corticosterone by PEE, the expression levels of testicular glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) were increased, while that of steroidogenic factor 1 (SF1) was decreased.	Corticosterone	46-60	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	198-220
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	271-285	histone deacetylase 2	Rattus norvegicus	180-185
30821590-6	2019	In utero, when fetal rats were overexposed to corticosterone by PEE, the expression levels of testicular glucocorticoid receptor (GR) and histone deacetylase 2 (HDAC2) were increased, while that of steroidogenic factor 1 (SF1) was decreased.	Corticosterone	46-60	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	222-225
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	271-285	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	133-136
30821590-9	2019	Taken together, PEE caused testicular dysplasia in male offspring rats, which was associated with corticosterone-induced low-functional programming of 3beta-HSD through the GR/SF1/HDAC2/H3K14ac pathway.	Corticosterone	98-112	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	151-160
30821590-7	2019	In vitro, corticosterone (rather than ethanol) at 500 to 2,000 nM concentration decreased testosterone production and 3beta-HSD expression in a concentration-dependent manner.	Corticosterone	10-24	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	118-127
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	39-42
30821590-9	2019	Taken together, PEE caused testicular dysplasia in male offspring rats, which was associated with corticosterone-induced low-functional programming of 3beta-HSD through the GR/SF1/HDAC2/H3K14ac pathway.	Corticosterone	98-112	G-rich RNA sequence binding factor 1	Rattus norvegicus	173-179
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	histone deacetylase 2	Rattus norvegicus	59-64
30821590-9	2019	Taken together, PEE caused testicular dysplasia in male offspring rats, which was associated with corticosterone-induced low-functional programming of 3beta-HSD through the GR/SF1/HDAC2/H3K14ac pathway.	Corticosterone	98-112	histone deacetylase 2	Rattus norvegicus	180-185
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	80-82
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	122-131
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	133-136
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	histone deacetylase 2	Rattus norvegicus	180-185
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	histone deacetylase 2	Rattus norvegicus	180-185
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	307-316
30821590-8	2019	Moreover, corticosterone downregulated SF1 and upregulated HDAC2 via activating GR, accompanied by a low H3K14ac level of 3beta-HSD; SF1 overexpression could reverse the increased HDAC2 expression, and knockdown of HDAC2 could partially reverse the inhibitory effects of corticosterone on H3K14ac level and 3beta-HSD expression but not on SF1 expression.	Corticosterone	10-24	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	133-136
30644034-1	2019	High level of corticosterone (CORT) is toxic to neurons and plays an important role in depression-like behavior and chronic stress.	Corticosterone	14-28	cortistatin	Rattus norvegicus	30-34
30597030-7	2019	Results: Plasma AgRP was stimulated by corticosterone in rats and correlated with hypothalamic AgRP expression.	Corticosterone	39-53	agouti related neuropeptide	Rattus norvegicus	16-20
30691851-9	2019	An explant model was used to measure corticosterone on the intestinal stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) and growth factors epidermal growth factor receptor and insulin-like growth factor-1.	Corticosterone	37-51	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	87-146
30691851-9	2019	An explant model was used to measure corticosterone on the intestinal stem cell marker Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5) and growth factors epidermal growth factor receptor and insulin-like growth factor-1.	Corticosterone	37-51	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	148-152
30691851-12	2019	Real-time polymerase chain reaction revealed that explants exposed to corticosterone had a decrease in LGR5 compared with controls and an increase in epidermal growth factor receptor.	Corticosterone	70-84	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	103-107
30691851-12	2019	Real-time polymerase chain reaction revealed that explants exposed to corticosterone had a decrease in LGR5 compared with controls and an increase in epidermal growth factor receptor.	Corticosterone	70-84	epidermal growth factor receptor	Mus musculus	150-182
30741599-1	2019	Corticosterone (CORT) is a glucocorticoid hormone that maintains energy balance and can modulate foraging behaviors in seabirds.	Corticosterone	0-14	CORT	Gallus gallus	16-20
30745564-7	2019	The observed significant reduction in SERT density in corticosterone-treated mice was independently validated by and correlated with western blot analysis.	Corticosterone	54-68	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	38-42
30573646-4	2019	Surprisingly, FAAH overexpression in BLA dampened stress-induced corticosterone release, reduced anxiety-like behaviors, and decreased conditioned fear expression.	Corticosterone	65-79	fatty-acid amide hydrolase-like	Rattus norvegicus	14-18
30745564-9	2019	The evidenced decrease in SERT density in response to chronic corticosterone treatment adds a new dimension to the complex involvement of SERT in the pathophysiology of stress-induced mental illnesses.	Corticosterone	62-76	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	26-30
30745564-9	2019	The evidenced decrease in SERT density in response to chronic corticosterone treatment adds a new dimension to the complex involvement of SERT in the pathophysiology of stress-induced mental illnesses.	Corticosterone	62-76	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	138-142
30550932-11	2019	Despite showing no pro-inflammatory changes to hippocampal mRNA, male CAS rats displayed lower plasma corticosterone response to LPS at 2 h after injection followed by an exaggerated plasma IL-1beta response at 4 h. This potentially blunted corticosterone response coupled with excessive innate immune signaling in the periphery is consistent with possible glucocorticoid resistance in males.	Corticosterone	241-255	interleukin 1 alpha	Rattus norvegicus	190-198
30414952-9	2019	Next we demonstrated that CORT increase, induced by chronic psychological stress, reduced GC response, IgG1 antibody production and miR-155 level in vivo.	Corticosterone	26-30	microRNA 155	Homo sapiens	132-139
30414952-12	2019	Furthermore, we found that miR-155 and BCL6 expression were downregulated, but FBXO11 expression was upregulated in GC B cells treated with CORT in vitro.	Corticosterone	140-144	microRNA 155	Homo sapiens	27-34
30414952-12	2019	Furthermore, we found that miR-155 and BCL6 expression were downregulated, but FBXO11 expression was upregulated in GC B cells treated with CORT in vitro.	Corticosterone	140-144	F-box protein 11	Homo sapiens	79-85
30414952-12	2019	Furthermore, we found that miR-155 and BCL6 expression were downregulated, but FBXO11 expression was upregulated in GC B cells treated with CORT in vitro.	Corticosterone	140-144	natriuretic peptide receptor 2	Homo sapiens	116-120
29667320-0	2019	Flotillin-1 interacts with the serotonin transporter and modulates chronic corticosterone response.	Corticosterone	75-89	flotillin 1	Homo sapiens	0-11
30455377-0	2019	Adipocyte Glucocorticoid Receptor Deficiency Promotes Adipose Tissue Expandability and Improves the Metabolic Profile Under Corticosterone Exposure.	Corticosterone	124-138	nuclear receptor subfamily 3, group C, member 1	Mus musculus	10-33
29667320-3	2019	Using behavioral and in vivo electrophysiological approaches together with biochemical, molecular-biological and molecular imaging tools we establish Flotillin-1 (Flot1) as a novel protein interacting with SERT and demonstrate its involvement in the response to chronic corticosterone (CORT) treatment.	Corticosterone	270-284	flotillin 1	Homo sapiens	150-161
29667320-3	2019	Using behavioral and in vivo electrophysiological approaches together with biochemical, molecular-biological and molecular imaging tools we establish Flotillin-1 (Flot1) as a novel protein interacting with SERT and demonstrate its involvement in the response to chronic corticosterone (CORT) treatment.	Corticosterone	270-284	flotillin 1	Homo sapiens	163-168
29948940-3	2019	In anesthetized rats, extracellular Zn2+ level was increased under local perfusion of the hippocampal CA1 with 500 ng/ml corticosterone.	Corticosterone	121-135	carbonic anhydrase 1	Rattus norvegicus	102-105
30284676-0	2019	Excessive corticosterone induces excitotoxicity of hippocampal neurons and sensitivity of potassium channels via insulin-signaling pathway.	Corticosterone	10-24	insulin	Homo sapiens	113-120
30284676-1	2019	Corticosterone (CORT) is a kind of corticosteroid produced by cortex of adrenal glands.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Corticosterone	133-147	carbonic anhydrase 1	Rattus norvegicus	64-67
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Corticosterone	288-302	carbonic anhydrase 1	Rattus norvegicus	8-11
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Corticosterone	288-302	carbonic anhydrase 1	Rattus norvegicus	64-67
30087452-8	2019	Notably, a significantly increased orexin level in VP is accompanied by an increase in serum corticosterone in animals exposed to acute stresses, including forced swimming, food/water deprivation and social rank stress, rather than non-stress situations.	Corticosterone	93-107	hypocretin neuropeptide precursor	Rattus norvegicus	35-41
30710078-3	2019	Here we show that the SGLT2 inhibitor (SGLT2i) dapagliflozin promotes ketoacidosis in both healthy and type 2 diabetic rats in the setting of insulinopenia through increased plasma catecholamine and corticosterone concentrations secondary to volume depletion.	Corticosterone	199-213	solute carrier family 5 member 2	Rattus norvegicus	22-27
30055194-5	2019	OCT3 is insensitive to inhibition by cocaine and antidepressant drugs but is inhibited directly by the glucocorticoid hormone corticosterone.	Corticosterone	126-140	OCTN3	Homo sapiens	0-4
30284340-15	2019	In rat colonic cells, glucocorticoid receptor and its co-chaperone proteins were down-regulated after corticosterone treatment and lubiprostone reversed these changes.	Corticosterone	102-116	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	22-45
30472394-8	2019	Oxytocin applications caused an elevation of corticosterone level after restriction in aggressive males, but did not affect expression of Crh, Crh1 and Crhr2 genes in hypothalamus in either tame or aggressive rats.	Corticosterone	45-59	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	0-8
30601756-14	2019	Overall, this study revealed that acute stress results in an increase in corticosterone, which may inhibit LH and FSH release in the serum and CYP11A1 and StAR expression in the ovary, which finally leads to the breakdown and shedding of the endometrium.	Corticosterone	73-87	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	143-150
30601756-14	2019	Overall, this study revealed that acute stress results in an increase in corticosterone, which may inhibit LH and FSH release in the serum and CYP11A1 and StAR expression in the ovary, which finally leads to the breakdown and shedding of the endometrium.	Corticosterone	73-87	steroidogenic acute regulatory protein	Mus musculus	155-159
30423288-5	2019	Corticosterone (1250 nM) suppressed osteogenic differentiation of BMSCs and gene expression of BGLAP, ALP and BSP, which was attenuated by enalapril, while it stimulated ACE mRNA expression and induced hypomethylation of ACE promoter, which was attenuated by mifepristone.	Corticosterone	0-14	bone gamma-carboxyglutamate protein	Rattus norvegicus	95-100
30423288-5	2019	Corticosterone (1250 nM) suppressed osteogenic differentiation of BMSCs and gene expression of BGLAP, ALP and BSP, which was attenuated by enalapril, while it stimulated ACE mRNA expression and induced hypomethylation of ACE promoter, which was attenuated by mifepristone.	Corticosterone	0-14	integrin-binding sialoprotein	Rattus norvegicus	110-113
30423288-5	2019	Corticosterone (1250 nM) suppressed osteogenic differentiation of BMSCs and gene expression of BGLAP, ALP and BSP, which was attenuated by enalapril, while it stimulated ACE mRNA expression and induced hypomethylation of ACE promoter, which was attenuated by mifepristone.	Corticosterone	0-14	angiotensin I converting enzyme	Rattus norvegicus	170-173
30423288-5	2019	Corticosterone (1250 nM) suppressed osteogenic differentiation of BMSCs and gene expression of BGLAP, ALP and BSP, which was attenuated by enalapril, while it stimulated ACE mRNA expression and induced hypomethylation of ACE promoter, which was attenuated by mifepristone.	Corticosterone	0-14	angiotensin I converting enzyme	Rattus norvegicus	221-224
30728784-6	2018	Compared with NOR rats, MD rats showed a significantly higher plasma corticosterone (CORT) level.	Corticosterone	69-83	cortistatin	Rattus norvegicus	85-89
29948940-4	2019	In vivo CA1 long-term potentiation (LTP) at Schaffer collateral-CA1 pyramidal cell synapses was attenuated by the pre-perfusion with corticosterone prior to tetanic stimulation, and the attenuation was canceled by co-perfusion with CaEDTA, an extracellular Zn2+ chelator, suggesting that corticosterone-induced increase in extracellular Zn2+ is involved in the subsequent attenuation of LTP.	Corticosterone	133-147	carbonic anhydrase 1	Rattus norvegicus	8-11
30118773-0	2019	Chronic corticosterone increases DeltaFOSB and CRFR1 immunoreactivity in brain regions that modulate aversive conditioning.	Corticosterone	8-22	corticotropin releasing hormone receptor 1	Homo sapiens	47-52
30343141-3	2019	TSPO-depleted homozygotes showed no response to adrenocorticotropic hormone (ACTH) in stimulating adrenal cortex corticosterone production but showed increased epinephrine synthesis in the medulla.	Corticosterone	113-127	translocator protein	Mus musculus	0-4
30176267-5	2019	METHODS AND RESULTS: We find decreased expression of Nr3c1 (glucocorticoid receptor - GR) and Fkbp5 (FK506 binding protein 5) in the amygdala and the hypothalamus of the DPP4mut rats, as well as the lower stress-induced peripheral corticosterone (CORT) levels.	Corticosterone	231-245	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	53-58
30176267-5	2019	METHODS AND RESULTS: We find decreased expression of Nr3c1 (glucocorticoid receptor - GR) and Fkbp5 (FK506 binding protein 5) in the amygdala and the hypothalamus of the DPP4mut rats, as well as the lower stress-induced peripheral corticosterone (CORT) levels.	Corticosterone	231-245	FKBP prolyl isomerase 5	Rattus norvegicus	94-99
30176267-5	2019	METHODS AND RESULTS: We find decreased expression of Nr3c1 (glucocorticoid receptor - GR) and Fkbp5 (FK506 binding protein 5) in the amygdala and the hypothalamus of the DPP4mut rats, as well as the lower stress-induced peripheral corticosterone (CORT) levels.	Corticosterone	231-245	FKBP prolyl isomerase 5	Rattus norvegicus	101-124
30118773-5	2019	To examine how treatment with chronic corticosterone interferes with CRFR1 expression we measured CRFR1 in the same brain structures that exhibited increased DeltaFosB-ir.	Corticosterone	38-52	corticotropin releasing hormone receptor 1	Homo sapiens	69-74
30118773-5	2019	To examine how treatment with chronic corticosterone interferes with CRFR1 expression we measured CRFR1 in the same brain structures that exhibited increased DeltaFosB-ir.	Corticosterone	38-52	corticotropin releasing hormone receptor 1	Homo sapiens	98-103
30118773-8	2019	Chronic treatment with corticosterone also increased CRFR1-immunoreactivity in the ventrolateral septum, central amygdala, dorsomedial hypothalamus, ventral region of the dorsal raphe and median raphe.	Corticosterone	23-37	corticotropin releasing hormone receptor 1	Homo sapiens	53-58
30033139-6	2019	Corticosterone and behavioral stress responsiveness was impaired in Rag2-/- mice reconstituted with CD8+ T cells.	Corticosterone	0-14	recombination activating gene 2	Mus musculus	68-72
30689544-4	2019	10nM aldosterone or corticosterone regulated CRY 1, PER1, PER2 and ReverbA (NR1D1) gene expression patterns in H9c2 cells over 24hr.	Corticosterone	20-34	cryptochrome circadian regulator 1	Rattus norvegicus	45-50
30689544-4	2019	10nM aldosterone or corticosterone regulated CRY 1, PER1, PER2 and ReverbA (NR1D1) gene expression patterns in H9c2 cells over 24hr.	Corticosterone	20-34	period circadian regulator 2	Rattus norvegicus	58-62
30689544-4	2019	10nM aldosterone or corticosterone regulated CRY 1, PER1, PER2 and ReverbA (NR1D1) gene expression patterns in H9c2 cells over 24hr.	Corticosterone	20-34	nuclear receptor subfamily 1, group D, member 1	Rattus norvegicus	76-81
29737454-9	2019	Moreover, animals with stabilized beta-catenin showed resilience to some anxious/depressive manifestations when subjected to the corticosterone model of depression.	Corticosterone	129-143	catenin (cadherin associated protein), beta 1	Mus musculus	34-46
31041873-9	2019	Finally, after stimulation of rat primary spinal cord neurons with exogenous corticosterone in vitro, neuronal PAS domain protein 4 and GABAergic markers were also downregulated, and RU486 reversed that.	Corticosterone	77-91	neuronal PAS domain protein 4	Rattus norvegicus	102-131
30339781-4	2019	The combination of these exposures with exogenous corticosterone (CORT), mimicking high physiological stress, exacerbates the observed neuroinflammation.	Corticosterone	50-64	cortistatin	Mus musculus	66-70
30627088-4	2018	Our data indicate that GR deletion in GABAergic neurons causes elevated corticosterone stress responsiveness and decreased cross-over latencies in a passive avoidance task in females, but not males.	Corticosterone	72-86	nuclear receptor subfamily 3, group C, member 1	Mus musculus	23-25
30292559-12	2019	Female R6/2 mice given WT-level corticosterone replacement also showed a reduction in HD neuropathological markers, including a reduction in mHTT inclusion burden in the striatum, cortex, and hippocampus (p < .05 for all).	Corticosterone	32-46	huntingtin	Mus musculus	141-145
30345859-0	2019	The effect of a corticotropin-releasing factor receptor 1 antagonist on the fear conditioning response in low- and high-anxiety rats after chronic corticosterone administration.	Corticosterone	147-161	corticotropin releasing hormone receptor 1	Rattus norvegicus	16-57
30345859-3	2019	Chronic corticosterone administration (by injection, 20 mg/kg) for 21 d (except weekends) increased freezing duration and number of GR (glucocorticoid receptor)-immunoreactive nuclei in the basal amygdala (BA) and decreased GR-immunoreactive nuclei in the infralimbic cortex (IL), dentate gyrus (DG), and CA3 area, only in the HR group.	Corticosterone	8-22	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	132-134
30345859-3	2019	Chronic corticosterone administration (by injection, 20 mg/kg) for 21 d (except weekends) increased freezing duration and number of GR (glucocorticoid receptor)-immunoreactive nuclei in the basal amygdala (BA) and decreased GR-immunoreactive nuclei in the infralimbic cortex (IL), dentate gyrus (DG), and CA3 area, only in the HR group.	Corticosterone	8-22	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	136-159
30345859-3	2019	Chronic corticosterone administration (by injection, 20 mg/kg) for 21 d (except weekends) increased freezing duration and number of GR (glucocorticoid receptor)-immunoreactive nuclei in the basal amygdala (BA) and decreased GR-immunoreactive nuclei in the infralimbic cortex (IL), dentate gyrus (DG), and CA3 area, only in the HR group.	Corticosterone	8-22	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	224-226
30345859-3	2019	Chronic corticosterone administration (by injection, 20 mg/kg) for 21 d (except weekends) increased freezing duration and number of GR (glucocorticoid receptor)-immunoreactive nuclei in the basal amygdala (BA) and decreased GR-immunoreactive nuclei in the infralimbic cortex (IL), dentate gyrus (DG), and CA3 area, only in the HR group.	Corticosterone	8-22	carbonic anhydrase 3	Rattus norvegicus	305-308
30345859-4	2019	Moreover, in this group, corticosterone administration decreased number of CRF-immunoreactive neurons of the parvocellular paraventricular hypothalamic nucleus (pPVN), DG, and CA1.	Corticosterone	25-39	carbonic anhydrase 1	Rattus norvegicus	176-179
30627637-3	2018	Rats have rhythmic clock gene expression in the vmPFC that requires appropriate diurnal circulatory patterns of corticosterone (CORT), suggesting the presence of CORT-entrained intrinsic circadian clock function within the PFC.	Corticosterone	112-126	cortistatin	Rattus norvegicus	128-132
30513893-8	2018	Peripheral profiles revealed a similar response pattern to SPS of OXT and corticosterone (CORT), and the SPS-induced increase in plasma levels of IL-1beta and TNF-alpha could be reduced by OXT.	Corticosterone	74-88	cortistatin	Rattus norvegicus	90-94
30562980-3	2018	The aim of the present study was to investigate the protective effects of Manninotriose and AS-IV on corticosterone (CORT) induced neurotoxicity and the underlying mechanisms.	Corticosterone	101-115	cortistatin	Rattus norvegicus	117-121
30532187-4	2018	Postprandial suppression of enhancer activity was associated with reduced glucocorticoid receptor (GR) and Forkhead box O1 (FOXO1) occupancy of chromatin correlating with reduced serum corticosterone levels and increased serum insulin levels.	Corticosterone	185-199	nuclear receptor subfamily 3 group C member 1	Homo sapiens	99-101
30532187-4	2018	Postprandial suppression of enhancer activity was associated with reduced glucocorticoid receptor (GR) and Forkhead box O1 (FOXO1) occupancy of chromatin correlating with reduced serum corticosterone levels and increased serum insulin levels.	Corticosterone	185-199	forkhead box O1	Homo sapiens	107-122
30532187-4	2018	Postprandial suppression of enhancer activity was associated with reduced glucocorticoid receptor (GR) and Forkhead box O1 (FOXO1) occupancy of chromatin correlating with reduced serum corticosterone levels and increased serum insulin levels.	Corticosterone	185-199	forkhead box O1	Homo sapiens	124-129
30273601-6	2018	In vitro experiments found that corticosterone instead of caffeine restrains mineralized nodule formation and osteoblast differentiation by inhibiting IGF1 expression.	Corticosterone	32-46	insulin-like growth factor 1	Rattus norvegicus	151-155
30273601-7	2018	The corticosterone inhibits H3K9 and H3K14 histone acetylation of IGF1 in osteoblasts through glucocorticoid receptor and CCAAT and enhancer binding protein alpha, respectively.	Corticosterone	4-18	insulin-like growth factor 1	Rattus norvegicus	66-70
30513893-8	2018	Peripheral profiles revealed a similar response pattern to SPS of OXT and corticosterone (CORT), and the SPS-induced increase in plasma levels of IL-1beta and TNF-alpha could be reduced by OXT.	Corticosterone	74-88	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	189-192
30136092-7	2018	In the hippocampus, the extract increased superoxide dismutase activity and reversed the increase in catalase activity elicited by corticosterone.	Corticosterone	131-145	catalase	Mus musculus	101-109
30802217-9	2018	TRPV1 KO mice showed the increased tail flick latencies and the lacking IM-induced corticosterone rise.	Corticosterone	83-97	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
29611102-2	2018	11beta-HSD1 is a key enzyme in the GCs pathway, catalyzing the conversion of 11beta-dehydrocorticosterone to corticosterone in mice, with possible implications in neurodegenerative processes and cognitive impairment.	Corticosterone	91-105	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	0-11
30315878-7	2018	In rats chronically administered oral corticosterone, mRNA and protein levels of Phox2b, but not Phox2a, in the LC were significantly increased.	Corticosterone	38-52	paired-like homeobox 2b	Rattus norvegicus	81-87
30268520-7	2018	Moreover, Bay 60-7550 decreased corticosterone-induced gp91phox expression, which is the source of ROS.	Corticosterone	32-46	paired Ig-like receptor B	Mus musculus	55-59
30171933-2	2018	To date most alcohol research has focused on the functional involvement of corticosterone and the glucocorticoid receptor (GR), the primary receptor for corticosterone.	Corticosterone	153-167	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	98-121
30171933-2	2018	To date most alcohol research has focused on the functional involvement of corticosterone and the glucocorticoid receptor (GR), the primary receptor for corticosterone.	Corticosterone	153-167	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	123-125
30171933-3	2018	Recent studies have indicated that the related mineralocorticoid receptor (MR), which binds both corticosterone and aldosterone, may also play a role in alcohol drinking.	Corticosterone	97-111	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	47-73
30171933-3	2018	Recent studies have indicated that the related mineralocorticoid receptor (MR), which binds both corticosterone and aldosterone, may also play a role in alcohol drinking.	Corticosterone	97-111	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	75-77
30588190-6	2018	We found increased body weight loss, the serum triglyceride levels, the expression of lipolysis-related genes, and serum corticosterone levels in the FR1 group compared with the FR2 group.	Corticosterone	121-135	aldo-keto reductase family 1, member B8	Mus musculus	150-153
30145227-3	2019	Here we reported that long-term corticosterone (CORT) exposure in mice induced weight gain, dyslipidemia as well as hyperglycaemia and systemic insulin resistance.	Corticosterone	32-46	insulin	Homo sapiens	144-151
30145227-3	2019	Here we reported that long-term corticosterone (CORT) exposure in mice induced weight gain, dyslipidemia as well as hyperglycaemia and systemic insulin resistance.	Corticosterone	48-52	insulin	Homo sapiens	144-151
30145227-4	2019	CORT-treated mice exhibited an increased 11beta-Hsd1 expression and corticosterone levels in fat depots but a specific upregulation of glucocorticoid receptor (Gr) and hexose-6-phosphate dehydrogenase only in gonadal adipose tissue, suggesting that GC could act differentially on various fat depots.	Corticosterone	0-4	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	41-52
29943435-4	2018	Male rats were exposed to the stress hormone corticosterone (Cort) in their drinking water, a vehicle control (2.5% ethanol), or water, for 7 days before being tested on a novel Object/Place task 6 days or 6 weeks later.	Corticosterone	45-59	cortistatin	Rattus norvegicus	61-65
30315878-7	2018	In rats chronically administered oral corticosterone, mRNA and protein levels of Phox2b, but not Phox2a, in the LC were significantly increased.	Corticosterone	38-52	paired-like homeobox 2a	Rattus norvegicus	97-103
30315878-8	2018	In addition, the corticosterone-induced increase in Phox2b protein was reversed by simultaneous treatment with either mifepristone or spironolactone.	Corticosterone	17-31	paired-like homeobox 2b	Rattus norvegicus	52-58
30315878-9	2018	Exposing SH-SY5Y cells to corticosterone significantly increased expression of Phox2a and Phox2b, which was blocked by corticosteroid receptor antagonists.	Corticosterone	26-40	paired like homeobox 2A	Homo sapiens	79-85
30315878-9	2018	Exposing SH-SY5Y cells to corticosterone significantly increased expression of Phox2a and Phox2b, which was blocked by corticosteroid receptor antagonists.	Corticosterone	26-40	paired like homeobox 2B	Homo sapiens	90-96
30356231-6	2018	The results showed that expression of POMC, CRF and GR mRNA and protein and serum levels of corticosterone were inhibited in response to stress.	Corticosterone	92-106	pro-opiomelanocortin-alpha	Mus musculus	38-42
30374301-2	2018	Repeated corticosterone (CORT) induces a consistent depression-like phenotype and has been widely used as an animal model to study neurobiological alterations underlying the depressive symptoms.	Corticosterone	9-23	cortistatin	Homo sapiens	25-29
30352070-1	2018	Vertebrates respond to stressful stimuli with the secretion of glucocorticoid (GC) hormones, such as corticosterone (CORT), and measurements of these hormones in wild species can provide insight into physiological responses to environmental and human-induced stressors.	Corticosterone	101-115	cortistatin	Homo sapiens	117-121
30282821-4	2018	Basal ACTH and corticosterone were similar in HP5 and WT mice, while HP5 mice showed attenuated ACTH and corticosterone responses to corticotrophin releasing hormone (CRH).	Corticosterone	105-119	corticotropin releasing hormone	Mus musculus	167-170
30322021-5	2018	Adolescent corticosterone (CORT) exposure increased alcohol, but not sucrose, self-administration, and enhanced stress-induced reinstatement with yohimbine in adulthood.	Corticosterone	11-25	cortistatin	Homo sapiens	27-31
30195057-5	2018	In this study, the effects of aldosterone and corticosterone on ENaC were examined in acute hypothalamic slices.	Corticosterone	46-60	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	64-68
30195057-6	2018	Real-time PCR and Western blot analysis showed that aldosterone and corticosterone treatment resulted in a significant increase in the expression of gammaENaC, but not alpha- or betaENaC, and that this expression was attenuated by MR and glucocorticoid receptor (GR) antagonists.	Corticosterone	68-82	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	231-233
30195057-6	2018	Real-time PCR and Western blot analysis showed that aldosterone and corticosterone treatment resulted in a significant increase in the expression of gammaENaC, but not alpha- or betaENaC, and that this expression was attenuated by MR and glucocorticoid receptor (GR) antagonists.	Corticosterone	68-82	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	238-261
30195057-6	2018	Real-time PCR and Western blot analysis showed that aldosterone and corticosterone treatment resulted in a significant increase in the expression of gammaENaC, but not alpha- or betaENaC, and that this expression was attenuated by MR and glucocorticoid receptor (GR) antagonists.	Corticosterone	68-82	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	263-265
30195057-9	2018	These results indicate that expression of gammaENaC in VP neurons is induced by aldosterone and corticosterone through their MR and GR, respectively; however, aldosterone or corticosterone alone is not sufficient enough to increase ENaC current when they are applied to hypothalamic slices in vitro.	Corticosterone	96-110	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	125-127
30195057-9	2018	These results indicate that expression of gammaENaC in VP neurons is induced by aldosterone and corticosterone through their MR and GR, respectively; however, aldosterone or corticosterone alone is not sufficient enough to increase ENaC current when they are applied to hypothalamic slices in vitro.	Corticosterone	96-110	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	132-134
30195057-9	2018	These results indicate that expression of gammaENaC in VP neurons is induced by aldosterone and corticosterone through their MR and GR, respectively; however, aldosterone or corticosterone alone is not sufficient enough to increase ENaC current when they are applied to hypothalamic slices in vitro.	Corticosterone	96-110	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	47-51
30195057-9	2018	These results indicate that expression of gammaENaC in VP neurons is induced by aldosterone and corticosterone through their MR and GR, respectively; however, aldosterone or corticosterone alone is not sufficient enough to increase ENaC current when they are applied to hypothalamic slices in vitro.	Corticosterone	174-188	sodium channel epithelial 1 subunit gamma	Rattus norvegicus	47-51
30287758-8	2018	Birds provided XPC or AVI had lower corticosterone and H/L ratios than CS (p &lt; 0.05) on day 19 and lower corticosterone, H/L ratios, and asymmetry scores than both CNS and CS on day 41 (p &lt; 0.05) in all three trials.	Corticosterone	36-50	XPC complex subunit, DNA damage recognition and repair factor	Gallus gallus	15-18
30287758-8	2018	Birds provided XPC or AVI had lower corticosterone and H/L ratios than CS (p &lt; 0.05) on day 19 and lower corticosterone, H/L ratios, and asymmetry scores than both CNS and CS on day 41 (p &lt; 0.05) in all three trials.	Corticosterone	108-122	XPC complex subunit, DNA damage recognition and repair factor	Gallus gallus	15-18
30010047-8	2018	Intriguingly, CBS overexpression increased the pre-TRH expression, slightly elevated plasma thyroxine and thyrotropin level, but decreased the plasma ACTH and corticosterone level.	Corticosterone	159-173	cystathionine beta synthase	Rattus norvegicus	14-17
29969314-13	2018	Those responses can be a direct effect of beta2 adrenergic receptor stimulation or/and of blocking the effects of LPS on corticosterone and IGF-I.	Corticosterone	121-135	adrenoceptor beta 2	Rattus norvegicus	42-67
29722134-0	2018	A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling.	Corticosterone	44-58	cAMP responsive element binding protein 1	Mus musculus	119-123
30353332-0	2018	Expression of Hif-1alpha, Nf-kappab, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1alpha, Erythropoietin, VEGF, TGF-beta, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia.	Corticosterone	154-168	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	14-24
30353332-0	2018	Expression of Hif-1alpha, Nf-kappab, and Vegf Genes in the Liver and Blood Serum Levels of HIF-1alpha, Erythropoietin, VEGF, TGF-beta, 8-Isoprostane, and Corticosterone in Wistar Rats with High and Low Resistance to Hypoxia.	Corticosterone	154-168	vascular endothelial growth factor A	Rattus norvegicus	26-45
29722134-6	2018	RESULTS: C36D significantly protected HT-22 cells against corticosterone-induced cytotoxicity and rescued corticosterone-induced decreases in cGMP, CREB phosphorylation, and BDNF expression.	Corticosterone	106-120	cAMP responsive element binding protein 1	Mus musculus	148-152
29722134-6	2018	RESULTS: C36D significantly protected HT-22 cells against corticosterone-induced cytotoxicity and rescued corticosterone-induced decreases in cGMP, CREB phosphorylation, and BDNF expression.	Corticosterone	106-120	brain derived neurotrophic factor	Mus musculus	174-178
29966748-9	2018	Analysis in vitro revealed that caffeine and corticosterone impeded the expression of IGF-1 signaling pathway aggrecan and COL2A1 genes, but only corticosterone decreased H3K9 and H3K27 acetylation in the IGF-1 promoter region.	Corticosterone	45-59	insulin-like growth factor 1	Rattus norvegicus	86-91
30206804-4	2018	In this research, we built the injury model of SH-SY5Y cells through 6-hydroxydopamine (6-OHDA) and corticosterone (CORT).	Corticosterone	100-114	cortistatin	Homo sapiens	116-120
30112578-6	2018	In experiment 3, blood corticosterone (CORT) was measured in response to 500 mg/kg 2-DG, alone or in combination with 40 mug/kg clonidine or 30 mg/kg bupropion.	Corticosterone	23-37	cortistatin	Rattus norvegicus	39-43
29807116-6	2018	The reported results indicate that (1) PFOS could inhibit HPA axis activity by diminishing gene and protein expression of CRF1r in the pituitary gland; (2) PFOS inhibits Gr protein expression in both prefrontal cortex and amygdala, which could be related to the toxic effects of this contaminant in this neuroendocrine axis and finally, (3) PFOS-treated rats would try to maintain the physiological levels of corticosterone by reducing the protein expression of Gr in the pituitary gland.	Corticosterone	409-423	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	170-172
29718108-4	2018	All progestagens as well as 11-deoxycorticosterone and corticosterone increased 100-200% with increasing concentrations of LAM suggesting a selective inhibitory effect of LAM on CYP17A1, in particular on the lyase reaction.	Corticosterone	36-50	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	178-185
29901761-1	2018	There are potential advantages for using noninvasive methods instead of conventional approaches for measuring corticosterone (CORT) as a metric of stress.	Corticosterone	110-124	CORT	Gallus gallus	126-130
29966748-10	2018	In concluson, PCE low functional programmed cartilage IGF-1 by histone acetylation modification via overexposure to corticosterone and delayed articular cartilage development from fetus to adults.	Corticosterone	116-130	insulin-like growth factor 1	Rattus norvegicus	54-59
29981921-5	2018	In primary osteoblastic cells, both nicotine (0, 162, 1620, 16,200 ng/ml) and corticosterone (0, 50, 250, 1250 nM) promoted the mRNA expression of OPG but concentration-dependently suppressed that of RANKL.	Corticosterone	78-92	TNF receptor superfamily member 11B	Rattus norvegicus	147-150
29981921-5	2018	In primary osteoblastic cells, both nicotine (0, 162, 1620, 16,200 ng/ml) and corticosterone (0, 50, 250, 1250 nM) promoted the mRNA expression of OPG but concentration-dependently suppressed that of RANKL.	Corticosterone	78-92	TNF superfamily member 11	Rattus norvegicus	200-205
29981921-6	2018	Furthermore, blocking alpha4beta2-nicotinic acetylcholine receptor (alpha4beta2-nAChR) or glucocorticoid receptor rescued the above effects of nicotine and corticosterone, respectively.	Corticosterone	156-170	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	22-113
30343560-9	2018	Chronic stress- or repeated corticosterone (CORT)- provoked malformation of the neuronal architecture was also suppressed by both exercise and treatment with 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).	Corticosterone	28-42	cortistatin	Mus musculus	44-48
30118751-8	2018	Immunoblot analyses revealed that autophosphorylation of Ca2+/calmodulin-dependent protein kinase (CaMK) IIalpha at threonine 286 and phosphorylation of cyclic-adenosine-monophosphate response-element-binding protein (CREB) at serine 133 were markedly increased in the BLA of chronic CORT-treated mice after tone stimulation.	Corticosterone	284-288	cAMP responsive element binding protein 1	Mus musculus	153-216
29966824-3	2018	Initial studies in naive male and female C57BL/6J mice confirmed that 30-min exposure to dirty rat bedding significantly increased plasma corticosterone (CORT) levels and anxiety-related behavior, justifying the use of dirty rat bedding as PS in the subsequent drinking studies.	Corticosterone	138-152	cortistatin	Rattus norvegicus	154-158
30060079-8	2018	In female rats gavaged with ATR, pretreatment with the CRH receptor antagonist astressin completely blocked the ATR-induced rise in corticosterone concentrations, implicating CRH release in ATR-induced HPA activation.	Corticosterone	132-146	corticotropin releasing hormone	Rattus norvegicus	55-58
30138609-2	2018	Intracerebroventricular (ICV) microinjection of VIP promotes increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone, indicating that VIP activates hypothalamic-pituitary-adrenal axis.	Corticosterone	118-132	vasoactive intestinal peptide	Rattus norvegicus	48-51
30138609-2	2018	Intracerebroventricular (ICV) microinjection of VIP promotes increased plasma adrenocorticotrophic hormone (ACTH) and corticosterone, indicating that VIP activates hypothalamic-pituitary-adrenal axis.	Corticosterone	118-132	vasoactive intestinal peptide	Rattus norvegicus	150-153
30138609-7	2018	Both antagonists also attenuated VIP-induced reduction and enhancement of free fatty acids and corticosterone plasma levels, respectively, and only AS30 was able to attenuate the hyperglycemia.	Corticosterone	95-109	vasoactive intestinal peptide	Rattus norvegicus	33-36
29688389-7	2018	Furthermore, chronic administration of corticosterone significantly increased Dkk-1 expression, decreased the phosphorylation of Ser9 of GSK-3beta, and resulted in the impairment of hippocampal learning and memory.	Corticosterone	39-53	dickkopf WNT signaling pathway inhibitor 1	Rattus norvegicus	78-83
29688389-7	2018	Furthermore, chronic administration of corticosterone significantly increased Dkk-1 expression, decreased the phosphorylation of Ser9 of GSK-3beta, and resulted in the impairment of hippocampal learning and memory.	Corticosterone	39-53	glycogen synthase kinase 3 beta	Rattus norvegicus	137-146
29966748-9	2018	Analysis in vitro revealed that caffeine and corticosterone impeded the expression of IGF-1 signaling pathway aggrecan and COL2A1 genes, but only corticosterone decreased H3K9 and H3K27 acetylation in the IGF-1 promoter region.	Corticosterone	45-59	collagen type II alpha 1 chain	Rattus norvegicus	123-129
29966748-9	2018	Analysis in vitro revealed that caffeine and corticosterone impeded the expression of IGF-1 signaling pathway aggrecan and COL2A1 genes, but only corticosterone decreased H3K9 and H3K27 acetylation in the IGF-1 promoter region.	Corticosterone	45-59	insulin-like growth factor 1	Rattus norvegicus	205-210
30069586-12	2018	CONCLUSIONS: These findings provide experimental evidence that GR activation due to elevated CORT levels induces the decrease of hippocampal astrocyte number in rats.	Corticosterone	93-97	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	63-65
30347920-3	2018	The effects of DZ (10, 100, 200, 500 mg L-1) on the expression of miR-16 and SERT mRNA in the cell model induced by miR-16 silencing and corticosterone or glutamate injury were observed in primary cultured hippocampal neurons of rats in vitro.	Corticosterone	137-151	solute carrier family 6 member 4	Rattus norvegicus	77-81
30347920-5	2018	At the same time, in primary cultured hippocampal neurons, 100, 200, 500 mg L-1 of DZ could significantly increase the expression level of miR-16 in miR-16 silencing and corticosterone or glutamate injury cell model, and decrease the expression level of SERT significantly.	Corticosterone	170-184	ribosomal protein L4	Rattus norvegicus	76-79
30347920-5	2018	At the same time, in primary cultured hippocampal neurons, 100, 200, 500 mg L-1 of DZ could significantly increase the expression level of miR-16 in miR-16 silencing and corticosterone or glutamate injury cell model, and decrease the expression level of SERT significantly.	Corticosterone	170-184	microRNA 16	Rattus norvegicus	139-145
29887536-0	2018	Corticosterone induces growth hormone expression in pituitary somatotrophs during goose embryonic development.	Corticosterone	0-14	growth hormone	Gallus gallus	23-37
30115912-9	2018	AdipoRon, a potent adiponectin receptor agonist, prevented the corticosterone-induced early onset of moderate obesity and metabolic syndromes.	Corticosterone	63-77	adiponectin, C1Q and collagen domain containing	Mus musculus	19-30
29981295-3	2018	The present study aimed to investigate the cholecalciferol capability to revert depressive-like behavior induced by chronic corticosterone (CORT) treatment in mice and its implication on the oxidative stress modulation.	Corticosterone	124-138	cortistatin	Mus musculus	140-144
30154689-3	2018	Previously, we demonstrated that stereotaxic application of the stress hormone corticosterone (CORT) onto the central nucleus of the amygdala (CeA) induces colonic hyperalgesia and anxiety-like behavior in a rat model, however the effect on intestinal permeability and mucosal function remain to be evaluated.	Corticosterone	79-93	cortistatin	Rattus norvegicus	95-99
30131681-1	2018	Maternal deprivation for 24 h produces an immediate increase in basal and stress-induced corticosterone (CORT) secretion.	Corticosterone	89-103	cortistatin	Rattus norvegicus	105-109
30154689-3	2018	Previously, we demonstrated that stereotaxic application of the stress hormone corticosterone (CORT) onto the central nucleus of the amygdala (CeA) induces colonic hyperalgesia and anxiety-like behavior in a rat model, however the effect on intestinal permeability and mucosal function remain to be evaluated.	Corticosterone	79-93	carcinoembryonic antigen gene family 4	Rattus norvegicus	143-146
30127743-5	2018	Analyses of Sort1-/- mice revealed that they display: (1) a corticosterone-independent anxiety-like behavior, (2) a resistance to depression as demonstrated by several behavioral tests, and (3) an increased activity of dorsal raphe nucleus neurons.	Corticosterone	60-74	sortilin 1	Mus musculus	12-17
29630906-3	2018	First, rats received corticosterone (CORT; 40 mg/kg, s.c.) or vehicle to induce a depressive-like phenotype.	Corticosterone	21-35	cortistatin	Rattus norvegicus	37-41
28864281-5	2018	An interaction of BDNF with stress was modelled by chronic young-adult treatment with corticosterone (CORT).	Corticosterone	86-100	brain derived neurotrophic factor	Mus musculus	18-22
29684438-10	2018	Gsn-/- mice on HFD displayed reduced corticosterone concentrations and reduced energy expenditure as compared to Gsn+/+ HFD mice.	Corticosterone	37-51	gelsolin	Mus musculus	0-3
29738736-5	2018	Corticosterone directly and acutely inhibits OCT3-mediated transport.	Corticosterone	0-14	OCTN3	Homo sapiens	45-49
29738736-7	2018	Evidence is presented supporting the hypothesis that corticosterone can exert rapid, GR-independent actions on neuronal physiology and behavior by inhibiting OCT3-mediated monoamine clearance.	Corticosterone	53-67	OCTN3	Homo sapiens	158-162
29894818-4	2018	The purpose of this study was to investigate the effects of chronic treatment with stress hormone corticosterone on Trx, TrxR and Txnip in cultured neuronal cells.	Corticosterone	98-112	thioredoxin	Homo sapiens	116-119
29894818-4	2018	The purpose of this study was to investigate the effects of chronic treatment with stress hormone corticosterone on Trx, TrxR and Txnip in cultured neuronal cells.	Corticosterone	98-112	peroxiredoxin 5	Homo sapiens	121-125
29894818-4	2018	The purpose of this study was to investigate the effects of chronic treatment with stress hormone corticosterone on Trx, TrxR and Txnip in cultured neuronal cells.	Corticosterone	98-112	thioredoxin interacting protein	Homo sapiens	130-135
29894818-6	2018	Using immunocytochemistry we also found that chronic corticosterone treatment increased Txnip in both nucleus and cytosol, while glucocorticoid receptor inhibitor RU486 can block corticosterone-increased Txnip protein levels.	Corticosterone	53-67	thioredoxin interacting protein	Homo sapiens	88-93
29894818-6	2018	Using immunocytochemistry we also found that chronic corticosterone treatment increased Txnip in both nucleus and cytosol, while glucocorticoid receptor inhibitor RU486 can block corticosterone-increased Txnip protein levels.	Corticosterone	53-67	thioredoxin interacting protein	Homo sapiens	204-209
29894818-6	2018	Using immunocytochemistry we also found that chronic corticosterone treatment increased Txnip in both nucleus and cytosol, while glucocorticoid receptor inhibitor RU486 can block corticosterone-increased Txnip protein levels.	Corticosterone	179-193	thioredoxin interacting protein	Homo sapiens	88-93
29894818-6	2018	Using immunocytochemistry we also found that chronic corticosterone treatment increased Txnip in both nucleus and cytosol, while glucocorticoid receptor inhibitor RU486 can block corticosterone-increased Txnip protein levels.	Corticosterone	179-193	nuclear receptor subfamily 3 group C member 1	Homo sapiens	129-152
29894818-6	2018	Using immunocytochemistry we also found that chronic corticosterone treatment increased Txnip in both nucleus and cytosol, while glucocorticoid receptor inhibitor RU486 can block corticosterone-increased Txnip protein levels.	Corticosterone	179-193	thioredoxin interacting protein	Homo sapiens	204-209
29894818-7	2018	Using biotin switch, dimedone conjugation and CRISPR/Cas9 methods we found that chronic corticosterone treatment increased protein nitrosylation and sulfenylation, while knocking out Txnip blocked corticosterone-induced protein nitrosylation and sulfenylation.	Corticosterone	197-211	thioredoxin interacting protein	Homo sapiens	183-188
29894818-8	2018	Since Trx can reduce cysteine oxidative protein modification such as nitrosylation and sulfenylation, our findings suggest that chronic corticosterone treatment may upregulate Txnip by targeting glucocorticoid receptor, subsequently inhibiting Trx activity and enhancing oxidative protein cysteine modification, which contributes to corticosterone-caused oxidative damage.	Corticosterone	136-150	thioredoxin	Homo sapiens	6-9
29894818-8	2018	Since Trx can reduce cysteine oxidative protein modification such as nitrosylation and sulfenylation, our findings suggest that chronic corticosterone treatment may upregulate Txnip by targeting glucocorticoid receptor, subsequently inhibiting Trx activity and enhancing oxidative protein cysteine modification, which contributes to corticosterone-caused oxidative damage.	Corticosterone	136-150	thioredoxin interacting protein	Homo sapiens	176-181
29894818-8	2018	Since Trx can reduce cysteine oxidative protein modification such as nitrosylation and sulfenylation, our findings suggest that chronic corticosterone treatment may upregulate Txnip by targeting glucocorticoid receptor, subsequently inhibiting Trx activity and enhancing oxidative protein cysteine modification, which contributes to corticosterone-caused oxidative damage.	Corticosterone	136-150	nuclear receptor subfamily 3 group C member 1	Homo sapiens	195-218
29894818-8	2018	Since Trx can reduce cysteine oxidative protein modification such as nitrosylation and sulfenylation, our findings suggest that chronic corticosterone treatment may upregulate Txnip by targeting glucocorticoid receptor, subsequently inhibiting Trx activity and enhancing oxidative protein cysteine modification, which contributes to corticosterone-caused oxidative damage.	Corticosterone	136-150	thioredoxin	Homo sapiens	244-247
29894818-8	2018	Since Trx can reduce cysteine oxidative protein modification such as nitrosylation and sulfenylation, our findings suggest that chronic corticosterone treatment may upregulate Txnip by targeting glucocorticoid receptor, subsequently inhibiting Trx activity and enhancing oxidative protein cysteine modification, which contributes to corticosterone-caused oxidative damage.	Corticosterone	333-347	thioredoxin	Homo sapiens	6-9
29894818-8	2018	Since Trx can reduce cysteine oxidative protein modification such as nitrosylation and sulfenylation, our findings suggest that chronic corticosterone treatment may upregulate Txnip by targeting glucocorticoid receptor, subsequently inhibiting Trx activity and enhancing oxidative protein cysteine modification, which contributes to corticosterone-caused oxidative damage.	Corticosterone	333-347	thioredoxin interacting protein	Homo sapiens	176-181
29625166-0	2018	Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6/TAK1 pathway.	Corticosterone	81-95	TNF receptor associated factor 6	Rattus norvegicus	132-137
29625166-0	2018	Neuroprotective effect of a physiological ratio of testosterone and estradiol on corticosterone-induced apoptosis in PC12 cells via Traf6/TAK1 pathway.	Corticosterone	81-95	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	138-142
29625166-8	2018	The current study demonstrated that an appropriate testosterone/estradiol ratio has a synergistic effect on PC12 cells injury induced by corticosterone through suppressing the activation of Traf6/TAK1 signaling pathway, suggesting that testosterone/estradiol might synergistically protect against neuronal apoptosis to ameliorate depressive symptoms.	Corticosterone	137-151	TNF receptor associated factor 6	Rattus norvegicus	190-195
29625166-8	2018	The current study demonstrated that an appropriate testosterone/estradiol ratio has a synergistic effect on PC12 cells injury induced by corticosterone through suppressing the activation of Traf6/TAK1 signaling pathway, suggesting that testosterone/estradiol might synergistically protect against neuronal apoptosis to ameliorate depressive symptoms.	Corticosterone	137-151	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	196-200
28864281-5	2018	An interaction of BDNF with stress was modelled by chronic young-adult treatment with corticosterone (CORT).	Corticosterone	102-106	brain derived neurotrophic factor	Mus musculus	18-22
30048476-10	2018	Serum corticosterone levels were slightly altered immediately after stress in both male and female mice deleted for Epac.	Corticosterone	6-20	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	116-120
29660438-9	2018	Moreover, in rat fetal chondrocytes, corticosterone rather than nicotine directly induced the hypoacetylation of H3K9 of TGFbetaR1 and COL2A1 genes, which might be the main cause of imperfect cartilage for PNE-F2.	Corticosterone	37-51	collagen type II alpha 1 chain	Rattus norvegicus	135-141
30065637-0	2018	Post-weaning Environmental Enrichment in Male CD-1 Mice: Impact on Social Behaviors, Corticosterone Levels and Prefrontal Cytokine Expression in Adulthood.	Corticosterone	85-99	CD1 antigen complex	Mus musculus	46-50
29100630-8	2018	The ability of systemic stress-level corticosterone treatment to potentiate cocaine-primed reinstatement was recapitulated by intra-PL injection of corticosterone, the CB1R agonist WIN 55,212-2, or the monoacylglycerol lipase inhibitor URB602.	Corticosterone	37-51	monoglyceride lipase	Rattus norvegicus	202-225
29928891-1	2018	Changes in corticosterone (CORT) and prolactin (PRL) levels are thought to provide complementary information on parental decisions in birds in the context of stressful situations.	Corticosterone	11-25	CORT	Gallus gallus	27-31
30042731-10	2018	We detected a significant increase in corticosterone levels in both serum and thymus samples of galectin-3-deficient mice, as compared to age-matched controls.	Corticosterone	38-52	lectin, galactose binding, soluble 3	Mus musculus	96-106
29718699-0	2018	Effect of a melanocortin type 2 receptor (MC2R) antagonist on the corticosterone response to hypoxia and ACTH stimulation in the neonatal rat.	Corticosterone	66-80	melanocortin 2 receptor	Rattus norvegicus	12-40
29718699-0	2018	Effect of a melanocortin type 2 receptor (MC2R) antagonist on the corticosterone response to hypoxia and ACTH stimulation in the neonatal rat.	Corticosterone	66-80	melanocortin 2 receptor	Rattus norvegicus	42-46
29533388-7	2018	Interestingly, these 3 pain states were associated with changes in glucocorticoid signalling, as indicated by the increased expression, at spinal cord level, of the glucocorticoid receptor isoform associated with glucocorticoid resistance, GRbeta, and increased levels of plasma corticosterone.	Corticosterone	279-293	nuclear receptor subfamily 3, group C, member 1	Mus musculus	165-188
29702445-13	2018	Although insulin restored basal corticosterone and 11beta-HSD1 activity (in hippocampus and plasma), the negative feedback regulation of corticosterone secretion after stress was still impaired in insulin-treated diabetic rats.	Corticosterone	32-46	insulin	Homo sapiens	9-16
29607713-1	2018	Maternal deprivation (MD) disinhibits the adrenal glands, rendering them responsive to various stressors, including saline injection, and this increased corticosterone (CORT) response can last for as long as 2 h. In the present study, we tested the hypothesis that association of MD on day 11 with a saline injection would alter emotional behavior, CORT response, and brain monoamine levels, in male and female adult rats.	Corticosterone	153-167	cortistatin	Rattus norvegicus	169-173
29555480-1	2018	Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder.	Corticosterone	40-54	cortistatin	Mus musculus	56-60
29959361-3	2018	Our current hypothesis was that NMS would change corticosterone activity through receptors (GR), which would modify molecules involved in zymogenic cell differentiation in rats.	Corticosterone	49-63	glutathione-disulfide reductase	Rattus norvegicus	92-94
29753741-4	2018	Although corticosterone reportedly causes selective apoptosis of CD4+CD8+ thymocytes (CD4+CD8+DPs) in mice treated with short-term HU, the reduction of thymocyte cellularity after the 14-day HU was not selective for CD4+CD8+DPs.	Corticosterone	9-23	CD4 antigen	Mus musculus	65-68
29753741-4	2018	Although corticosterone reportedly causes selective apoptosis of CD4+CD8+ thymocytes (CD4+CD8+DPs) in mice treated with short-term HU, the reduction of thymocyte cellularity after the 14-day HU was not selective for CD4+CD8+DPs.	Corticosterone	9-23	CD4 antigen	Mus musculus	86-89
29753741-4	2018	Although corticosterone reportedly causes selective apoptosis of CD4+CD8+ thymocytes (CD4+CD8+DPs) in mice treated with short-term HU, the reduction of thymocyte cellularity after the 14-day HU was not selective for CD4+CD8+DPs.	Corticosterone	9-23	CD4 antigen	Mus musculus	86-89
30046455-4	2018	We previously showed a transgenerational modification to male offspring anxiety-like behaviours by treatment of adult male breeders with corticosterone (CORT) prior to mating.	Corticosterone	137-151	cortistatin	Homo sapiens	153-157
29879378-5	2018	We found that the vast majority of Mrap-/- mice died at birth but could be rescued by administration of corticosterone to pregnant dams.	Corticosterone	104-118	melanocortin 2 receptor accessory protein	Mus musculus	35-39
29385813-7	2018	Musk reduced both corticosterone levels and the hippocampal neurodegenerative changes observed after exposure to CUMS.	Corticosterone	18-32	muscle, skeletal, receptor tyrosine kinase	Mus musculus	0-4
29721586-7	2018	Serum CBG levels in all three PFOA groups also increased, accompanied by increased corticosterone in the 5 and 20 mg/kg/day groups and decreased adrenocorticotropic hormone in the 20 mg/kg/day group.	Corticosterone	83-97	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	6-9
29555828-8	2018	The obtained results indicated that 5-HT1A but not the 5-HT1B/D or 5-HT2 receptors in the PVN are engaged in the negative neuroendocrine regulation of cytochrome P450 via the stimulation of hypothalamic somatostatin secretion and in the decreases in the serum growth hormone and corticosterone concentrations.	Corticosterone	279-293	5-hydroxytryptamine receptor 1A	Rattus norvegicus	36-42
28744834-4	2018	Supplementation of corticosterone and cortisol promoted leptin production in murine adipocytes from the 3T3-L1 cell strain and human adipocytes from the Simpson Golabi-Behmel syndrome (SGBS) cell strain, respectively.	Corticosterone	19-33	leptin	Mus musculus	56-62
28726298-4	2018	Furthermore, TLR3 activation increased plasma corticosterone levels, induced fever, and reduced locomotor activity and body weight - effects independent of sex.	Corticosterone	46-60	toll-like receptor 3	Rattus norvegicus	13-17
29654794-7	2018	Increased levels of plasma corticosterone (CORT), glutamate in nucleus accumbens (NAC), hypothalamus (HYP) and prefrontal cortex (PFC) indicate stress and excitotoxicity.	Corticosterone	27-41	cortistatin	Rattus norvegicus	43-47
29457656-9	2018	Male and female FABP 5/7 KO mice showed reduced corticosterone levels under stress compared to their WT counterparts.	Corticosterone	48-62	fatty acid binding protein 5, epidermal	Mus musculus	16-22
29457656-10	2018	The reduction in corticosterone response under stress may mediate that lack of a stress-induced preference for cocaine in the FABP 5/7 KO mice.	Corticosterone	17-31	fatty acid binding protein 5, epidermal	Mus musculus	126-132
29855476-6	2018	Furthermore, corticosterone increased the expression of the glucocorticoid receptor (GR) and GAD67 in foetal hippocampal H19-7 cells in a concentration-dependent manner, accompanied by demethylation of the GAD67 promoter, a decrease in glutamatergic neurons and increase in GABAergic neurons.	Corticosterone	13-27	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	60-83
29855476-6	2018	Furthermore, corticosterone increased the expression of the glucocorticoid receptor (GR) and GAD67 in foetal hippocampal H19-7 cells in a concentration-dependent manner, accompanied by demethylation of the GAD67 promoter, a decrease in glutamatergic neurons and increase in GABAergic neurons.	Corticosterone	13-27	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	85-87
29855476-6	2018	Furthermore, corticosterone increased the expression of the glucocorticoid receptor (GR) and GAD67 in foetal hippocampal H19-7 cells in a concentration-dependent manner, accompanied by demethylation of the GAD67 promoter, a decrease in glutamatergic neurons and increase in GABAergic neurons.	Corticosterone	13-27	glutamate decarboxylase 1	Rattus norvegicus	93-98
29855476-6	2018	Furthermore, corticosterone increased the expression of the glucocorticoid receptor (GR) and GAD67 in foetal hippocampal H19-7 cells in a concentration-dependent manner, accompanied by demethylation of the GAD67 promoter, a decrease in glutamatergic neurons and increase in GABAergic neurons.	Corticosterone	13-27	glutamate decarboxylase 1	Rattus norvegicus	206-211
29855476-7	2018	The GR inhibitor, mifepristone, reversed the effects of corticosterone on H19-7 cells.	Corticosterone	56-70	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	4-6
29855476-8	2018	These results suggested that PEE-induced excessive corticosterone can lead to upregulation of GAD67 through epigenetic modification mediated by the GR in the male foetal hippocampus, thereby weakening the negative regulation of the HPAA by the hippocampus and increasing the potential excitatory ability of the hypothalamus.	Corticosterone	51-65	glutamate decarboxylase 1	Rattus norvegicus	94-99
29855476-8	2018	These results suggested that PEE-induced excessive corticosterone can lead to upregulation of GAD67 through epigenetic modification mediated by the GR in the male foetal hippocampus, thereby weakening the negative regulation of the HPAA by the hippocampus and increasing the potential excitatory ability of the hypothalamus.	Corticosterone	51-65	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	148-150
29776424-10	2018	Furthermore, we show that increased corticosterone (CORT) levels can inhibit CD8 T cells and that blocking CORT in vivo following SCI enhances CD8 T cell antiviral responses.	Corticosterone	36-50	cortistatin	Mus musculus	52-56
29596965-0	2018	Oxytocin Inhibits Corticosterone-induced Apoptosis in Primary Hippocampal Neurons.	Corticosterone	18-32	oxytocin	Mus musculus	0-8
29596965-2	2018	Glucocorticoids, corticosterone (CORT) in rodents and cortisol in humans, are adrenal steroids which are released in response to stressful stimuli.	Corticosterone	17-31	cortistatin	Homo sapiens	33-37
29898391-3	2018	Inducible genetic silencing of Klf9 expression in excitatory forebrain neurons in adulthood prior to, but not after, onset of stressor prevented chronic restraint stress (CRS)-induced potentiation of contextual fear acquisition in female mice and chronic corticosterone (CORT) exposure-induced fear generalization in male mice.	Corticosterone	255-269	Kruppel-like factor 9	Mus musculus	31-35
29898391-3	2018	Inducible genetic silencing of Klf9 expression in excitatory forebrain neurons in adulthood prior to, but not after, onset of stressor prevented chronic restraint stress (CRS)-induced potentiation of contextual fear acquisition in female mice and chronic corticosterone (CORT) exposure-induced fear generalization in male mice.	Corticosterone	271-275	Kruppel-like factor 9	Mus musculus	31-35
29452193-2	2018	Chronic administration of corticosterone (CORT) to rodents is used to mimic the stress associated dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, a well-established feature found in depressive patients.	Corticosterone	26-40	cortistatin	Homo sapiens	42-46
29625124-8	2018	In vivo, glucocorticoid corticosterone treatment (100 mug/mL) increased fasting blood glucose and plasma IL-6 levels in C57BL/6 N mice.	Corticosterone	24-38	interleukin 6	Mus musculus	105-109
29625124-9	2018	Theophylline administration (0.1% diet) reduced corticosterone-increased fasting blood glucose, plasma IL-6 levels, and Il6 gene expression in adipose tissues.	Corticosterone	48-62	interleukin 6	Mus musculus	103-107
29625124-9	2018	Theophylline administration (0.1% diet) reduced corticosterone-increased fasting blood glucose, plasma IL-6 levels, and Il6 gene expression in adipose tissues.	Corticosterone	48-62	interleukin 6	Mus musculus	120-123
29427582-0	2018	Increased plasma nesfatin-1 levels may be associated with corticosterone, IL-6, and CRP levels in patients with major depressive disorder.	Corticosterone	58-72	nucleobindin 2	Homo sapiens	17-27
29427582-7	2018	Positive correlation was found between nesfatin-1 and corticosterone (r = 0.305, P = 0.007), IL-6 (r = 0.333, P = 0.003), and CRP (r = 0.244, P = 0.034) concentrations.	Corticosterone	54-68	nucleobindin 2	Homo sapiens	39-49
29427582-8	2018	CONCLUSIONS: Increased plasma nesfatin-1 levels may be associated with corticosterone, IL-6, and CRP levels in patients with major depressive disorder.	Corticosterone	71-85	nucleobindin 2	Homo sapiens	30-40
28550529-15	2018	Single administration of HBK-15 (1.25 mg/kg) and ketamine (1 mg/kg) reversed depression-like behavior and regulated decreased BDNF level in the hippocampus in corticosterone-treated mice.	Corticosterone	159-173	brain derived neurotrophic factor	Mus musculus	126-130
29713278-13	2018	DHEA can prevent the negative effects of excessive corticosterone by modulating HSD11B1 activity.	Corticosterone	51-65	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	80-87
29555470-5	2018	We found that corticosterone (CORT) induced by acute stress caused a potentiation of ASICs current via glucocorticoid receptors (GRs) not mineralocorticoid receptors (MRs).	Corticosterone	14-28	cortistatin	Rattus norvegicus	30-34
29230949-10	2018	Furthermore, pre-incubation with 0.1 muM corticosterone increased C2C12 cell viability during heat exposure and mitochondrial and nuclear GR expression.	Corticosterone	41-55	nuclear receptor subfamily 3, group C, member 1	Mus musculus	138-140
29438841-11	2018	Additionally, TSC could attenuate the reduction of 5-HT, DA and NE induced by corticosterone in primary neuronal cells.	Corticosterone	78-92	solute carrier family 12 member 3	Rattus norvegicus	14-17
29191401-10	2018	As expected, cortisone and 11-dehydrocorticosterone levels exceed those of cortisol and corticosterone in umbilical cord blood reflecting the strong placental 11-beta-hydroxysteroid-dehydrogenase type 2 (11betaHSD2) activity.	Corticosterone	37-51	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	159-214
29496660-10	2018	When the antagonist was used in combination with an OCT3 (organic cation transporter 3) inhibitor, corticosterone, the anticontractile effect was completely abolished.	Corticosterone	99-113	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	52-56
29496660-10	2018	When the antagonist was used in combination with an OCT3 (organic cation transporter 3) inhibitor, corticosterone, the anticontractile effect was completely abolished.	Corticosterone	99-113	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	58-86
29329057-1	2018	BACKGROUND: Stress hormones such as corticosterone (CORT) play an essential role in the development of depression.	Corticosterone	36-50	cortistatin	Rattus norvegicus	52-56
29462352-0	2018	Inhibition of corticosterone synthesis and its effect on acute phase proteins, heat shock protein 70, and interleukin-6 in broiler chickens subjected to feed restriction.	Corticosterone	14-28	heat shock protein family A (Hsp70) member 2	Gallus gallus	79-100
29462352-0	2018	Inhibition of corticosterone synthesis and its effect on acute phase proteins, heat shock protein 70, and interleukin-6 in broiler chickens subjected to feed restriction.	Corticosterone	14-28	interleukin 6	Gallus gallus	106-119
29549885-5	2018	Recent research in a mouse model of GWI has shown that pre-exposure with the stress hormone corticosterone (CORT) causes an increase in expression of specific chemokines and cytokines in response to diisopropyl fluorophosphate (DFP), a sarin surrogate and irreversible AChE inhibitor.	Corticosterone	92-106	acetylcholinesterase	Mus musculus	269-273
29549885-5	2018	Recent research in a mouse model of GWI has shown that pre-exposure with the stress hormone corticosterone (CORT) causes an increase in expression of specific chemokines and cytokines in response to diisopropyl fluorophosphate (DFP), a sarin surrogate and irreversible AChE inhibitor.	Corticosterone	108-112	acetylcholinesterase	Mus musculus	269-273
29162628-9	2018	Diabetes-like alterations were accompanied by enduring hyperfunction of opioid- and ACTH-corticosterone-endogenous structures in the brain, which were apparently due to failure of negative feedback hormone mechanisms in the pituitary, for the control of the hypothalamus-pituitary-adrenal axis.	Corticosterone	89-103	pro-opiomelanocortin-alpha	Mus musculus	84-88
29223529-5	2018	Corticosterone (CORT) was used to induce stress conditions; CORT damaged the function of gap junctions, which resulted from less distribution of connexin43 (Cx43) on membranes and the enhanced phosphorylation of Cx43 at S368.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
29223529-5	2018	Corticosterone (CORT) was used to induce stress conditions; CORT damaged the function of gap junctions, which resulted from less distribution of connexin43 (Cx43) on membranes and the enhanced phosphorylation of Cx43 at S368.	Corticosterone	0-14	cortistatin	Homo sapiens	60-64
29223529-5	2018	Corticosterone (CORT) was used to induce stress conditions; CORT damaged the function of gap junctions, which resulted from less distribution of connexin43 (Cx43) on membranes and the enhanced phosphorylation of Cx43 at S368.	Corticosterone	0-14	gap junction protein alpha 1	Homo sapiens	145-155
29223529-5	2018	Corticosterone (CORT) was used to induce stress conditions; CORT damaged the function of gap junctions, which resulted from less distribution of connexin43 (Cx43) on membranes and the enhanced phosphorylation of Cx43 at S368.	Corticosterone	0-14	gap junction protein alpha 1	Homo sapiens	157-161
29223529-5	2018	Corticosterone (CORT) was used to induce stress conditions; CORT damaged the function of gap junctions, which resulted from less distribution of connexin43 (Cx43) on membranes and the enhanced phosphorylation of Cx43 at S368.	Corticosterone	0-14	gap junction protein alpha 1	Homo sapiens	212-216
29162628-10	2018	In conclusion, for the first time we can hypothesize that a diabetes-like syndrome is produced by enduring hyperfunction of two proopiomelanocortin-dependent endogenous systems (brain opioid- and ACTH-corticosterone systems), following failure of pituitary feedback hormonal control, after complex stress procedures.	Corticosterone	201-215	pro-opiomelanocortin-alpha	Mus musculus	196-200
29339018-9	2018	Besides, chronic nicotine also enhanced the protein and RNA expression levels of autophagy makers triggered by corticosterone, such as Beclin-1, LC3 II and p62/SQSTM1.	Corticosterone	111-125	beclin 1, autophagy related	Mus musculus	135-143
29339018-9	2018	Besides, chronic nicotine also enhanced the protein and RNA expression levels of autophagy makers triggered by corticosterone, such as Beclin-1, LC3 II and p62/SQSTM1.	Corticosterone	111-125	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	145-148
29339018-9	2018	Besides, chronic nicotine also enhanced the protein and RNA expression levels of autophagy makers triggered by corticosterone, such as Beclin-1, LC3 II and p62/SQSTM1.	Corticosterone	111-125	sequestosome 1	Mus musculus	156-159
29339018-9	2018	Besides, chronic nicotine also enhanced the protein and RNA expression levels of autophagy makers triggered by corticosterone, such as Beclin-1, LC3 II and p62/SQSTM1.	Corticosterone	111-125	sequestosome 1	Mus musculus	160-166
29339018-12	2018	Consequently, chronic nicotine played a role of neuroprotection in either CUS mice or corticosterone cells associating with the enhancement of the autophagy signaling, which was involved in activating the PI3K/Akt/mTOR signaling.	Corticosterone	86-100	thymoma viral proto-oncogene 1	Mus musculus	210-213
29339018-12	2018	Consequently, chronic nicotine played a role of neuroprotection in either CUS mice or corticosterone cells associating with the enhancement of the autophagy signaling, which was involved in activating the PI3K/Akt/mTOR signaling.	Corticosterone	86-100	mechanistic target of rapamycin kinase	Mus musculus	214-218
29343424-7	2018	Moreover, in the rat primary adrenal cells, corticosterone (rather than caffeine) was shown to significantly inhibit cell proliferation, IGF1 and PCNA expression, and ERK phosphorylation, which could be reversed by exogenous IGF1.	Corticosterone	44-58	insulin-like growth factor 1	Rattus norvegicus	137-141
29310485-9	2018	The resting hypothalamic CRH mRNA was higher in KO mice with reduced stressor-induced corticosterone elevations.	Corticosterone	86-100	corticotropin releasing hormone	Mus musculus	25-28
29352046-8	2018	Selective ablation of PVN-CRFR1 neurons in male mice elevates corticosterone release during a stress response and slows the decrease in circulating corticosterone levels after the cessation of stress.	Corticosterone	62-76	corticotropin releasing hormone receptor 1	Mus musculus	22-31
29352046-8	2018	Selective ablation of PVN-CRFR1 neurons in male mice elevates corticosterone release during a stress response and slows the decrease in circulating corticosterone levels after the cessation of stress.	Corticosterone	148-162	corticotropin releasing hormone receptor 1	Mus musculus	22-31
29343424-7	2018	Moreover, in the rat primary adrenal cells, corticosterone (rather than caffeine) was shown to significantly inhibit cell proliferation, IGF1 and PCNA expression, and ERK phosphorylation, which could be reversed by exogenous IGF1.	Corticosterone	44-58	proliferating cell nuclear antigen	Rattus norvegicus	146-150
29343424-7	2018	Moreover, in the rat primary adrenal cells, corticosterone (rather than caffeine) was shown to significantly inhibit cell proliferation, IGF1 and PCNA expression, and ERK phosphorylation, which could be reversed by exogenous IGF1.	Corticosterone	44-58	Eph receptor B1	Rattus norvegicus	167-170
29343424-7	2018	Moreover, in the rat primary adrenal cells, corticosterone (rather than caffeine) was shown to significantly inhibit cell proliferation, IGF1 and PCNA expression, and ERK phosphorylation, which could be reversed by exogenous IGF1.	Corticosterone	44-58	insulin-like growth factor 1	Rattus norvegicus	225-229
29229396-9	2018	Corticosterone (CORT) levels were quantified at 24h and 21days after TBI.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
29456490-5	2018	Furthermore, we determined plasma levels of leptin, ghrelin, and corticosterone hormones, which are well-known to control the levels of endocannabioids and/or CB1 receptors in the brain.	Corticosterone	65-79	cannabinoid receptor 1	Rattus norvegicus	159-162
29054677-9	2018	Lastly, corticosterone rescued the anxiety-like phenotype and messenger RNA levels of Ppm1f in amygdala and mPFC in male mice and in mPFC of female mice.	Corticosterone	8-22	protein phosphatase 1F (PP2C domain containing)	Mus musculus	86-91
29126194-6	2018	Ang II-high salt elevated plasma corticosterone, aldosterone and endogenous ouabain but not Ang II alone.	Corticosterone	33-47	angiotensinogen	Rattus norvegicus	0-6
29289659-7	2018	Both Prkar1a-/- mice and R1A-Epac1KO mice have increased circulating thyroxine and corticosterone concentrations.	Corticosterone	83-97	protein kinase, cAMP dependent regulatory, type I, alpha	Mus musculus	5-12
29515447-2	2018	Previous work in our lab has demonstrated that repeated corticosterone (CORT) injections in rats reliably increase depressive-like behavior, impair hippocampal-dependent memory, reduce the number and complexity of adult-generated neurons in the dentate gyrus, decrease hippocampal reelin expression, and alter markers of GABAergic function.	Corticosterone	56-70	reelin	Rattus norvegicus	281-287
29515447-2	2018	Previous work in our lab has demonstrated that repeated corticosterone (CORT) injections in rats reliably increase depressive-like behavior, impair hippocampal-dependent memory, reduce the number and complexity of adult-generated neurons in the dentate gyrus, decrease hippocampal reelin expression, and alter markers of GABAergic function.	Corticosterone	72-76	reelin	Rattus norvegicus	281-287
29289659-7	2018	Both Prkar1a-/- mice and R1A-Epac1KO mice have increased circulating thyroxine and corticosterone concentrations.	Corticosterone	83-97	Rap guanine nucleotide exchange factor (GEF) 3	Mus musculus	29-34
29373584-0	2018	Epigallocatechin-3-gallate confers protection against corticosterone-induced neuron injuries via restoring extracellular signal-regulated kinase 1/2 and phosphatidylinositol-3 kinase/protein kinase B signaling pathways.	Corticosterone	54-68	mitogen-activated protein kinase 1	Homo sapiens	107-182
29373584-0	2018	Epigallocatechin-3-gallate confers protection against corticosterone-induced neuron injuries via restoring extracellular signal-regulated kinase 1/2 and phosphatidylinositol-3 kinase/protein kinase B signaling pathways.	Corticosterone	54-68	protein tyrosine kinase 2 beta	Homo sapiens	183-199
29373584-2	2018	Here we provide evidence to support the possible involvement of extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol-3 kinase/ protein kinase B (PI3K/AKT) pathways in EGCG-mediated protection against corticosterone-induced neuron injuries.	Corticosterone	223-237	mitogen-activated protein kinase 1	Homo sapiens	64-105
29373584-2	2018	Here we provide evidence to support the possible involvement of extracellular signal-regulated kinase 1/2 (ERK1/2) and phosphatidylinositol-3 kinase/ protein kinase B (PI3K/AKT) pathways in EGCG-mediated protection against corticosterone-induced neuron injuries.	Corticosterone	223-237	mitogen-activated protein kinase 3	Homo sapiens	107-113
29373584-4	2018	Pre-treatment with EGCG ameliorated the corticosterone-induced neuronal injuries; however, it was blocked by pharmacological inhibitors for ERK1/2 (U0126) and PI3K/AKT (LY294002).	Corticosterone	40-54	mitogen-activated protein kinase 3	Homo sapiens	140-146
29373584-4	2018	Pre-treatment with EGCG ameliorated the corticosterone-induced neuronal injuries; however, it was blocked by pharmacological inhibitors for ERK1/2 (U0126) and PI3K/AKT (LY294002).	Corticosterone	40-54	AKT serine/threonine kinase 1	Homo sapiens	164-167
29373584-5	2018	Furthermore, the results confirmed that EGCG restored the corticosterone-induced decrease of ERK1/2 and PI3K/AKT phosphorylation, and attenuated the corticosterone-induced reduction of peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression and ATP production.	Corticosterone	58-72	mitogen-activated protein kinase 3	Homo sapiens	93-99
29373584-5	2018	Furthermore, the results confirmed that EGCG restored the corticosterone-induced decrease of ERK1/2 and PI3K/AKT phosphorylation, and attenuated the corticosterone-induced reduction of peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression and ATP production.	Corticosterone	58-72	AKT serine/threonine kinase 1	Homo sapiens	109-112
29373584-5	2018	Furthermore, the results confirmed that EGCG restored the corticosterone-induced decrease of ERK1/2 and PI3K/AKT phosphorylation, and attenuated the corticosterone-induced reduction of peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression and ATP production.	Corticosterone	58-72	PPARG coactivator 1 alpha	Homo sapiens	255-265
29373584-5	2018	Furthermore, the results confirmed that EGCG restored the corticosterone-induced decrease of ERK1/2 and PI3K/AKT phosphorylation, and attenuated the corticosterone-induced reduction of peroxisome proliferators-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression and ATP production.	Corticosterone	149-163	PPARG coactivator 1 alpha	Homo sapiens	255-265
29373584-6	2018	Taken together, these findings indicated that EGCG has significant neuroprotection against corticosterone-induced neuron injuries partly via restoring the ERK1/2 and PI3K/AKT signaling pathways as well as the PGC-1alpha-mediated ATP production.	Corticosterone	91-105	mitogen-activated protein kinase 3	Homo sapiens	155-161
29373584-6	2018	Taken together, these findings indicated that EGCG has significant neuroprotection against corticosterone-induced neuron injuries partly via restoring the ERK1/2 and PI3K/AKT signaling pathways as well as the PGC-1alpha-mediated ATP production.	Corticosterone	91-105	AKT serine/threonine kinase 1	Homo sapiens	171-174
29373584-6	2018	Taken together, these findings indicated that EGCG has significant neuroprotection against corticosterone-induced neuron injuries partly via restoring the ERK1/2 and PI3K/AKT signaling pathways as well as the PGC-1alpha-mediated ATP production.	Corticosterone	91-105	PPARG coactivator 1 alpha	Homo sapiens	209-219
29403490-0	2018	Corticosterone Preexposure Increases NF-kappaB Translocation and Sensitizes IL-1beta Responses in BV2 Microglia-Like Cells.	Corticosterone	0-14	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-46
29403490-0	2018	Corticosterone Preexposure Increases NF-kappaB Translocation and Sensitizes IL-1beta Responses in BV2 Microglia-Like Cells.	Corticosterone	0-14	interleukin 1 beta	Mus musculus	76-84
28864207-5	2018	Water intake and plasma corticosterone and testosterone levels were significantly increased by RLN3, but not by RXFP3-A2.	Corticosterone	24-38	relaxin 3	Rattus norvegicus	95-99
28889022-5	2018	Plasma corticosterone (CORT) level was also higher in PPD rats.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
29127254-4	2018	Specific reductions in the levels of progesterone and corticosterone as well as age-dependent androgen deficiency were observed in both young and aged male TSPO-KO mice.	Corticosterone	54-68	translocator protein	Mus musculus	156-160
29063347-0	2018	Nrf2 Signaling Pathway Mediates the Antioxidative Effects of Taurine Against Corticosterone-Induced Cell Death in HUMAN SK-N-SH Cells.	Corticosterone	77-91	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
29063347-9	2018	These results suggest that the Nrf2 signaling pathway may play a role in the protection mechanism of taurine against CORT-induced neuronal oxidative damage.	Corticosterone	117-121	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
31149231-5	2018	Corticosterone stayed high during 60 days of CUMS; after 40 days, body weight, cholesterol and triglycerides decreased and glucose intolerance was evident at day 60; insulin and ghrelin increased at 20 and 40 days, respectively; leptin decreased after day 20.	Corticosterone	0-14	leptin	Rattus norvegicus	229-235
28877880-6	2018	Several factors important in fluid balance regulation, vasopressin (AVP), natriuretic peptides, and corticosterone (CORT), also changed significantly postinjury.	Corticosterone	100-114	cortistatin	Rattus norvegicus	116-120
29863081-4	2018	When vasopressin was injected into crowding-stressed rats to assess corticosterone secretion via pituitary-adorenocortical axis activation, vasopressin-induced increase in serum corticosterone was significantly attenuated compared to non-stressed control rats, indicating that the pituitary-adrenocortical response to vasopressin is affected after exposure to crowding stress.	Corticosterone	68-82	arginine vasopressin	Rattus norvegicus	5-16
29863081-4	2018	When vasopressin was injected into crowding-stressed rats to assess corticosterone secretion via pituitary-adorenocortical axis activation, vasopressin-induced increase in serum corticosterone was significantly attenuated compared to non-stressed control rats, indicating that the pituitary-adrenocortical response to vasopressin is affected after exposure to crowding stress.	Corticosterone	68-82	arginine vasopressin	Rattus norvegicus	140-151
29863081-4	2018	When vasopressin was injected into crowding-stressed rats to assess corticosterone secretion via pituitary-adorenocortical axis activation, vasopressin-induced increase in serum corticosterone was significantly attenuated compared to non-stressed control rats, indicating that the pituitary-adrenocortical response to vasopressin is affected after exposure to crowding stress.	Corticosterone	68-82	arginine vasopressin	Rattus norvegicus	140-151
29863081-4	2018	When vasopressin was injected into crowding-stressed rats to assess corticosterone secretion via pituitary-adorenocortical axis activation, vasopressin-induced increase in serum corticosterone was significantly attenuated compared to non-stressed control rats, indicating that the pituitary-adrenocortical response to vasopressin is affected after exposure to crowding stress.	Corticosterone	178-192	arginine vasopressin	Rattus norvegicus	5-16
29863081-4	2018	When vasopressin was injected into crowding-stressed rats to assess corticosterone secretion via pituitary-adorenocortical axis activation, vasopressin-induced increase in serum corticosterone was significantly attenuated compared to non-stressed control rats, indicating that the pituitary-adrenocortical response to vasopressin is affected after exposure to crowding stress.	Corticosterone	178-192	arginine vasopressin	Rattus norvegicus	140-151
29863081-4	2018	When vasopressin was injected into crowding-stressed rats to assess corticosterone secretion via pituitary-adorenocortical axis activation, vasopressin-induced increase in serum corticosterone was significantly attenuated compared to non-stressed control rats, indicating that the pituitary-adrenocortical response to vasopressin is affected after exposure to crowding stress.	Corticosterone	178-192	arginine vasopressin	Rattus norvegicus	140-151
29863081-5	2018	Interestingly, administration of YKS-containing water rescued attenuation of vasopressin-induced increase in serum corticosterone.	Corticosterone	115-129	arginine vasopressin	Rattus norvegicus	77-88
29065218-7	2018	Corticosterone for MDCK-rMATE1 and MDCK-MDR1 and pyrimethamine for MDCK-rMATE1 at high concentrations could inhibit the efflux of berberine.	Corticosterone	0-14	solute carrier family 47 member 1	Rattus norvegicus	24-30
29065218-7	2018	Corticosterone for MDCK-rMATE1 and MDCK-MDR1 and pyrimethamine for MDCK-rMATE1 at high concentrations could inhibit the efflux of berberine.	Corticosterone	0-14	solute carrier family 47 member 1	Rattus norvegicus	72-78
28893563-4	2018	Although LPS markedly (and IFN-gamma modestly in some cases) increased cytokine and corticosterone levels, while inducing pronounced sickness and home-cage activity deficits, the G2019S mutation had no effect on these parameters.	Corticosterone	84-98	interferon gamma	Mus musculus	27-36
29674117-5	2018	METHODS: We quantify Bdnf transcript levels and dendritic spine density and morphology on cortical pyramidal neurons in mice exposed to vehicle or corticosterone and receiving either Sham or ECS treatment.	Corticosterone	147-161	brain derived neurotrophic factor	Mus musculus	21-25
29125184-9	2018	Serum samples were obtained to assay corticosterone levels, a GR activator.	Corticosterone	37-51	nuclear receptor subfamily 3, group C, member 1	Mus musculus	62-64
28963397-5	2018	Consistently, SBT-induced fear-associated behaviors, SBT-evoked elevated blood pressure, and increased serum levels of the stress hormone corticosterone were clearly reduced in GC-G-knockout animals compared to wild-type mice.	Corticosterone	138-152	glucagon	Mus musculus	177-181
29125184-15	2018	Corticosterone levels, a GR ligand, were increased in the blood post-SE.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Mus musculus	25-27
29186699-5	2018	Gabrd/Crh mice exhibit blunted seizure-induced elevations in corticosterone, establishing a useful tool to investigate the contribution of HPA axis dysfunction on epilepsy and associated comorbidities.	Corticosterone	61-75	gamma-aminobutyric acid (GABA) A receptor, subunit delta	Mus musculus	0-5
29186699-5	2018	Gabrd/Crh mice exhibit blunted seizure-induced elevations in corticosterone, establishing a useful tool to investigate the contribution of HPA axis dysfunction on epilepsy and associated comorbidities.	Corticosterone	61-75	corticotropin releasing hormone	Mus musculus	6-9
29186699-8	2018	Seizure susceptibility and associated depression-like behaviors can be restored to wild type levels by treating Gabrd/Crh mice with exogenous corticosterone.	Corticosterone	142-156	gamma-aminobutyric acid (GABA) A receptor, subunit delta	Mus musculus	112-117
29186699-8	2018	Seizure susceptibility and associated depression-like behaviors can be restored to wild type levels by treating Gabrd/Crh mice with exogenous corticosterone.	Corticosterone	142-156	corticotropin releasing hormone	Mus musculus	118-121
29046340-10	2018	Further, we demonstrated that both under expression or overexpression of NNT reduced corticosterone output implying a central role for it in the control of steroidogenesis.	Corticosterone	85-99	nicotinamide nucleotide transhydrogenase	Mus musculus	73-76
29077837-6	2018	CNO increased corticosterone secretion in rats transfected at C1m or A1/C1 but not A1.	Corticosterone	14-28	biogenesis of lysosomal organelles complex 1 subunit 4	Rattus norvegicus	0-3
29077837-8	2018	These results show that selective activation of C1 CA neurons is sufficient to increase feeding, blood glucose levels, and corticosterone secretion and suggest that each of these responses is mediated by CA neurons concentrated at different levels of the C1 cell group.	Corticosterone	123-137	complement C1r	Rattus norvegicus	48-50
29087473-2	2018	The ubiquitously expressed enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activates mouse corticosterone from 11-dehydrocorticosterone (and human cortisol from cortisone).	Corticosterone	107-121	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	78-89
30092582-7	2018	TRH administration in the PVN also promptly increased body temperature, locomotor activity and plasma corticosterone concentrations.	Corticosterone	102-116	thyrotropin releasing hormone	Rattus norvegicus	0-3
29270114-5	2017	Here, we exposed mice to the primary stress hormone corticosterone (CORT) during early adolescence (postnatal days 31-42), then tested behavioral flexibility in adulthood using an instrumental reversal learning task.	Corticosterone	52-66	cortistatin	Mus musculus	68-72
29212023-6	2017	DISC1 dysfunction alters corticosterone-induced mitochondrial Ca2+ accumulation in an oxidative stress-dependent manner.	Corticosterone	25-39	DISC1 scaffold protein	Homo sapiens	0-5
28985390-2	2017	Corticosterone (CORT), the primary avian glucocorticoid, regulates energetic reserves to meet metabolic demands.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
28899903-7	2017	Nonetheless, SF1 Socs3 KO mice exhibited a blunted ACTH-induced corticosterone secretion.	Corticosterone	64-78	splicing factor 1	Mus musculus	13-16
28899903-7	2017	Nonetheless, SF1 Socs3 KO mice exhibited a blunted ACTH-induced corticosterone secretion.	Corticosterone	64-78	suppressor of cytokine signaling 3	Mus musculus	17-22
28899903-7	2017	Nonetheless, SF1 Socs3 KO mice exhibited a blunted ACTH-induced corticosterone secretion.	Corticosterone	64-78	pro-opiomelanocortin-alpha	Mus musculus	51-55
27914009-7	2017	In response to restraint AS, instant stress reactivity including locomotor behavior and corticosterone induction was impaired in Srf mutant mice.	Corticosterone	88-102	serum response factor	Mus musculus	129-132
29304053-6	2018	Here, we examined the effects of the stress hormone, corticosterone (CORT), as a stressor mimic, on neuroinflammation induced with a single injection (2mg/kg, s.c.) or inhalation exposure (7.5 mug/m3) of LPS or polyinosinic:polycytidylic acid (PIC; 12mg/kg, i.p.)	Corticosterone	53-67	cortistatin	Mus musculus	69-73
28752412-8	2018	Plasma corticosterone concentration was significantly increased after VIP or OVT.	Corticosterone	7-21	vasoactive intestinal peptide	Rattus norvegicus	70-73
29115641-8	2018	Furthermore, the significant increase in circulating adrenocorticotrophic hormone (ACTH) and corticosterone (CORT) concentrations in the T3 group were inhibited by CART 55-102 administration to the PVN, in particular CORT levels were significantly decreased.	Corticosterone	93-107	CART prepropeptide	Rattus norvegicus	164-168
29115641-8	2018	Furthermore, the significant increase in circulating adrenocorticotrophic hormone (ACTH) and corticosterone (CORT) concentrations in the T3 group were inhibited by CART 55-102 administration to the PVN, in particular CORT levels were significantly decreased.	Corticosterone	109-113	CART prepropeptide	Rattus norvegicus	164-168
28964735-5	2018	To investigate this, we treated rat dams daily with high levels of corticosterone (CORT; 40 mg/kg), to induce a depressive-like phenotype, or oil (vehicle for CORT) during the postpartum period.	Corticosterone	67-81	cortistatin	Rattus norvegicus	83-87
29920498-9	2018	However, mebicar or ginsenoside Rg1 prevented elevation of serum corticosterone and secretion of proinflammatory cytokines from splenocytes due to IUS exposure.	Corticosterone	65-79	protein phosphatase 1, regulatory subunit 3A	Mus musculus	32-35
29168240-2	2018	The levels of melatonin (MEL) and corticosterone (CORT) hormones were investigated simultaneously, by the Luminex  immunoassay system in mice plasma, after Citrus aurantium and Citrus sinensis EOs inhalation for 30 min.	Corticosterone	34-48	cortistatin	Mus musculus	50-54
29065362-9	2018	At hypothalamic level both cannabinoid receptors (CB1 and CB2) are involved, while in the adrenal gland, anandamide has a very potent effect in suppressing ACTH-induced corticosterone release that is mainly mediated by vanilloid TRPV1 receptors.	Corticosterone	169-183	cannabinoid receptor 1	Rattus norvegicus	50-53
29065362-9	2018	At hypothalamic level both cannabinoid receptors (CB1 and CB2) are involved, while in the adrenal gland, anandamide has a very potent effect in suppressing ACTH-induced corticosterone release that is mainly mediated by vanilloid TRPV1 receptors.	Corticosterone	169-183	cannabinoid receptor 2	Rattus norvegicus	58-61
29141867-7	2017	These findings suggest that neuroendocrine axes are crucial for tolerization of the innate immune system to microbial endotoxin exposure through direct corticosterone-mediated effects on NKp46-expressing innate cells, revealing a novel strategy of host protection from immunopathology.	Corticosterone	152-166	natural cytotoxicity triggering receptor 1	Mus musculus	187-192
28993273-5	2017	We further observed that stress-induced enhanced serum corticosterone stimulated mitochondrial recruitment of glucocorticoid receptor (GR), which contributed to gut mitochondrial dysfunctions as documented from reduced ETC complex 1 activity, mitochondrial O2 - accumulation, depolarization and hyper-fission.	Corticosterone	55-69	nuclear receptor subfamily 3 group C member 1	Homo sapiens	110-133
28993273-5	2017	We further observed that stress-induced enhanced serum corticosterone stimulated mitochondrial recruitment of glucocorticoid receptor (GR), which contributed to gut mitochondrial dysfunctions as documented from reduced ETC complex 1 activity, mitochondrial O2 - accumulation, depolarization and hyper-fission.	Corticosterone	55-69	nuclear receptor subfamily 3 group C member 1	Homo sapiens	135-137
29107098-5	2017	Corticosterone exposure decreased levels of the dendrite stabilization factor Abl2/Arg nonreceptor tyrosine kinase and phosphorylation of its substrates p190RhoGAP and cortactin within 11days, suggesting that disruption of Arg-mediated signaling may trigger dendrite arbor atrophy and, potentially, behavioral abnormalities resulting from corticosterone exposure.	Corticosterone	0-14	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	78-82
29107098-5	2017	Corticosterone exposure decreased levels of the dendrite stabilization factor Abl2/Arg nonreceptor tyrosine kinase and phosphorylation of its substrates p190RhoGAP and cortactin within 11days, suggesting that disruption of Arg-mediated signaling may trigger dendrite arbor atrophy and, potentially, behavioral abnormalities resulting from corticosterone exposure.	Corticosterone	0-14	Rho GTPase activating protein 35	Homo sapiens	153-163
29107098-5	2017	Corticosterone exposure decreased levels of the dendrite stabilization factor Abl2/Arg nonreceptor tyrosine kinase and phosphorylation of its substrates p190RhoGAP and cortactin within 11days, suggesting that disruption of Arg-mediated signaling may trigger dendrite arbor atrophy and, potentially, behavioral abnormalities resulting from corticosterone exposure.	Corticosterone	0-14	cortactin	Homo sapiens	168-177
28951321-4	2017	Here, we examined whether the stress hormone corticosterone (CORT) would enhance memory in a hippocampal-dependent trace fear conditioning test.	Corticosterone	45-59	cortistatin	Rattus norvegicus	61-65
29208684-6	2017	Furthermore, central NPY decreased plasma glucose and triacylglycerol under CT and HT and kept plasma corticosterone and epinephrine lower under HT NPY increased plasma taurine and anserine concentrations.	Corticosterone	102-116	neuropeptide Y	Homo sapiens	21-24
28910603-7	2017	The results indicate that apoA-IV KO increases post-stress corticosterone and anxiety-related behavior specifically in the 129 strain, and increases stress-induced hyperglycemia exclusively in the C57 strain.	Corticosterone	59-73	apolipoprotein A-IV	Mus musculus	26-33
28911811-3	2017	Under the basal state, serum corticosterone (CORT) and glucose of some PEE groups were lowered while those of serum triglycerides (TG) were increased comparing with controls.	Corticosterone	29-43	cortistatin	Rattus norvegicus	45-49
28902436-0	2017	Neuroprotective effect of amantadine on corticosterone-induced abnormal glutamatergic synaptic transmission of CA3-CA1 pathway in rat"s hippocampal slices.	Corticosterone	40-54	carbonic anhydrase 3	Rattus norvegicus	111-118
28902436-10	2017	Additionally, the superoxide dismutase (SOD) and catalase (CAT) activities were reduced by corticosterone, while they were enhanced by either amantadine or low-calcium artificial cerebral spinal fluid (ACSF).	Corticosterone	91-105	catalase	Rattus norvegicus	49-57
28902436-10	2017	Additionally, the superoxide dismutase (SOD) and catalase (CAT) activities were reduced by corticosterone, while they were enhanced by either amantadine or low-calcium artificial cerebral spinal fluid (ACSF).	Corticosterone	91-105	catalase	Rattus norvegicus	59-62
28902436-11	2017	These results suggest that amantadine significantly improves corticosterone-induced abnormal glutamatergic synaptic transmission of CA3-CA1 synapses presynaptically and alleviates the activities of antioxidant enzymes via regulating the calcium influx.	Corticosterone	61-75	carbonic anhydrase 3	Rattus norvegicus	132-139
29186135-7	2017	Administration of the trkB agonist 7,8-dihydroxyflavone (7,8-DHF) during adolescence at doses that stimulated ERK42/44 corrected long-lasting corticosterone-induced behavioral abnormalities.	Corticosterone	142-156	neurotrophic receptor tyrosine kinase 2	Homo sapiens	22-26
29125588-2	2017	In the present study, we tested the hypothesis that activation of the HPA axis by corticosterone treatment can reverse liver inflammation and fibrosis in a multidrug resistance protein 2 knockout (MDR2KO) transgenic mouse model of hepatic cholestasis.	Corticosterone	82-96	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	156-186
29125588-5	2017	MDR2KO mice had lower corticotropin releasing hormone and corticosterone levels than FVBN controls in the serum.	Corticosterone	58-72	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	0-4
29125588-6	2017	There was a large accumulation of CD68 and F4/80 macrophages in MDR2KO mice livers, which indicated greater inflammation compared to FVBNs, an effect reversed by corticosterone treatment.	Corticosterone	162-176	CD68 antigen	Mus musculus	34-38
29125588-6	2017	There was a large accumulation of CD68 and F4/80 macrophages in MDR2KO mice livers, which indicated greater inflammation compared to FVBNs, an effect reversed by corticosterone treatment.	Corticosterone	162-176	adhesion G protein-coupled receptor E1	Mus musculus	43-48
29125588-6	2017	There was a large accumulation of CD68 and F4/80 macrophages in MDR2KO mice livers, which indicated greater inflammation compared to FVBNs, an effect reversed by corticosterone treatment.	Corticosterone	162-176	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	64-68
29125588-8	2017	When looking at the gender-specific response to corticosterone treatment, male MDR2KO mice tended to have a more pronounced reversal of liver fibrosis than females treated with corticosterone.	Corticosterone	48-62	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Mus musculus	79-83
29125864-4	2017	The administration of a serotonin 2C receptor (5-HT2CR) antagonist suppressed plasma corticosterone but did not affect the reduction in food intake.	Corticosterone	85-99	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	24-54
29046340-11	2018	This is likely due to a reduction in the expression of a key steroidogenic enzyme, Cyp11a1, which mirrored the reduction in corticosterone output.	Corticosterone	124-138	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	83-90
28675823-0	2017	Endothelial immunocytochemical expression of pituitary IL-1beta and its relation to ACTH-positive cells is regulated by corticosterone in the male rat.	Corticosterone	120-134	interleukin 1 beta	Rattus norvegicus	55-63
28765040-1	2017	The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) contributes to intracellular glucocorticoid action by converting inactive cortisone to its receptor-active form cortisol (11-dehydrocorticosterone and corticosterone in mice and rats).	Corticosterone	200-214	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	55-66
29072695-8	2017	In vitro, a high-concentration corticosterone (1250 nM) upregulated Mig-6 expression, inhibit EGFR/c-Jun N-terminal kinase (JNK) signaling pathway and terminal differentiation genes expression in chondrocytes and reduced cell apoptosis, and these above alterations could be partly reversed step-by-step after Mig-6 and EGFR knockdown.	Corticosterone	31-45	ERBB receptor feedback inhibitor 1	Rattus norvegicus	68-73
29072695-8	2017	In vitro, a high-concentration corticosterone (1250 nM) upregulated Mig-6 expression, inhibit EGFR/c-Jun N-terminal kinase (JNK) signaling pathway and terminal differentiation genes expression in chondrocytes and reduced cell apoptosis, and these above alterations could be partly reversed step-by-step after Mig-6 and EGFR knockdown.	Corticosterone	31-45	epidermal growth factor receptor	Rattus norvegicus	94-98
29072695-8	2017	In vitro, a high-concentration corticosterone (1250 nM) upregulated Mig-6 expression, inhibit EGFR/c-Jun N-terminal kinase (JNK) signaling pathway and terminal differentiation genes expression in chondrocytes and reduced cell apoptosis, and these above alterations could be partly reversed step-by-step after Mig-6 and EGFR knockdown.	Corticosterone	31-45	mitogen-activated protein kinase 8	Rattus norvegicus	124-127
29072695-8	2017	In vitro, a high-concentration corticosterone (1250 nM) upregulated Mig-6 expression, inhibit EGFR/c-Jun N-terminal kinase (JNK) signaling pathway and terminal differentiation genes expression in chondrocytes and reduced cell apoptosis, and these above alterations could be partly reversed step-by-step after Mig-6 and EGFR knockdown.	Corticosterone	31-45	ERBB receptor feedback inhibitor 1	Rattus norvegicus	309-314
29072695-8	2017	In vitro, a high-concentration corticosterone (1250 nM) upregulated Mig-6 expression, inhibit EGFR/c-Jun N-terminal kinase (JNK) signaling pathway and terminal differentiation genes expression in chondrocytes and reduced cell apoptosis, and these above alterations could be partly reversed step-by-step after Mig-6 and EGFR knockdown.	Corticosterone	31-45	epidermal growth factor receptor	Rattus norvegicus	319-323
28089704-1	2017	We will highlight in honor of Randall Sakai the peculiar characteristics of the brain mineralocorticoid receptor (MR) in its response pattern to the classical mineralocorticoid aldosterone and the naturally occurring glucocorticoids corticosterone and cortisol.	Corticosterone	233-247	nuclear receptor subfamily 3 group C member 2	Homo sapiens	86-112
28652137-8	2017	More importantly, we revealed a subspecies-specific stress response at the level of corticosterone production: while the significant effect of ACTH was proved in both subspecies, a notable adrenocortical reaction was also elicited by injecting the saline solution in M. m. domesticus.	Corticosterone	84-98	pro-opiomelanocortin-alpha	Mus musculus	143-147
28663379-7	2017	Pulmonary corticosterone levels were negatively correlated with IL-1beta, IL-18, and MCP-1.	Corticosterone	10-24	interleukin 1 beta	Mus musculus	64-72
28663379-7	2017	Pulmonary corticosterone levels were negatively correlated with IL-1beta, IL-18, and MCP-1.	Corticosterone	10-24	interleukin 18	Mus musculus	74-79
28663379-7	2017	Pulmonary corticosterone levels were negatively correlated with IL-1beta, IL-18, and MCP-1.	Corticosterone	10-24	chemokine (C-C motif) ligand 2	Mus musculus	85-90
28663379-12	2017	These findings indicate that exercise training increases pulmonary expression of 11beta-HSD1, thus contributing to local GC activation and suppression of pulmonary inflammation in obese mice.NEW &amp; NOTEWORTHY Treadmill training leads to a significant increase in pulmonary corticosterone levels in ob/ob mice, which is in parallel with the favorable effects of exercise on obesity-associated pulmonary inflammation.	Corticosterone	276-290	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	81-92
27714631-2	2017	In the present study, we investigated the ability of creatine to counteract the morphological and behavioral effects elicited by chronic administration of corticosterone (CORT, 20 mg/kg, p.o.)	Corticosterone	155-169	cortistatin	Mus musculus	171-175
28647675-2	2017	Here, we investigated effects of repeated ethanol intoxication-withdrawal cycles (using chronic intermittent ethanol vapor inhalation; CIE) and abstinence from CIE on peak and nadir plasma corticosterone (CORT) levels.	Corticosterone	189-203	cortistatin	Rattus norvegicus	205-209
28736330-4	2017	CX3CR1-/- animals display active escape in forced swim- and tail suspension tests, exaggerated neuronal activation in the hypothalamic paraventricular nucleus and increased corticosterone release in response to restraint.	Corticosterone	173-187	chemokine (C-X3-C motif) receptor 1	Mus musculus	0-6
28911199-6	2017	Armc5 heterozygote mice (Armc5+/-) developed normally but at the age of 1 year, their corticosterone levels decreased; this was associated with a decrease of protein kinase A (PKA) catalytic subunit alpha (Calpha) expression both at the RNA and protein levels that were also seen in human patients with PMAH and ARMC5 defects.	Corticosterone	86-100	armadillo repeat containing 5	Mus musculus	0-5
28887454-9	2017	Instead, NaPi-IIb-/- mice fed LDP had exacerbated hypercalciuria, higher urinary excretion of corticosterone and deoxypyridinoline, lower bone mineral density and higher number of osteoclasts.	Corticosterone	94-108	solute carrier family 34 (sodium phosphate), member 2	Mus musculus	9-17
28938481-8	2017	In previously unstressed rats, vGluT1 siRNA significantly enhanced ACTH and corticosterone secretion.	Corticosterone	76-90	solute carrier family 17 member 7	Rattus norvegicus	31-37
28938481-9	2017	Compared with CVS animals receiving the green fluorescent protein control vector, the vGluT1 siRNA further increased basal and stress-induced corticosterone release.	Corticosterone	142-156	solute carrier family 17 member 7	Rattus norvegicus	86-92
28754259-1	2017	The bioavailability of glucocorticoids is modulated by enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1), which catalyzes the conversion of inactive 11-oxo-glucocorticoids to active 11-hydroxy-glucocorticoids cortisol and corticosterone and is regulated by pro-inflammatory cytokines.	Corticosterone	231-245	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	62-104
28754259-1	2017	The bioavailability of glucocorticoids is modulated by enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1), which catalyzes the conversion of inactive 11-oxo-glucocorticoids to active 11-hydroxy-glucocorticoids cortisol and corticosterone and is regulated by pro-inflammatory cytokines.	Corticosterone	231-245	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	106-112
28751144-5	2017	The results showed that the expression and activity of H6PDH and 11beta-HSD1 in livers of diabetic rats were increased, with the expressions of PEPCK and G6Pase or liver corticosterone increased apparently.	Corticosterone	170-184	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	55-60
28751144-7	2017	With H6PDH siRNA, the enhancement of gluconeogenesis was blocked and insulin resistance stimulated by corticosterone was reduced.	Corticosterone	102-116	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	5-10
28709706-2	2017	Kidney 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) is an NAD+-dependent oxidase that inactivates glucocorticoid cortisol (human) or corticosterone (rodents) into biologically inert 11 keto glucocorticoids.	Corticosterone	140-154	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	7-44
28709706-2	2017	Kidney 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) is an NAD+-dependent oxidase that inactivates glucocorticoid cortisol (human) or corticosterone (rodents) into biologically inert 11 keto glucocorticoids.	Corticosterone	140-154	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	46-57
28521187-2	2017	This study aimed to investigate the effects of mirtazapine (MIRT) alone and combined with alpha-lipoic acid (ALA) against corticosterone (CORT) induced behavioral and oxidative alterations.	Corticosterone	122-136	cortistatin	Homo sapiens	138-142
28737969-6	2017	Moreover, immobilization stress elevated the mRNA levels of tyrosine hydroxylase (Th), dopamine beta-hydroxylase (Dbh), and cytochrome P450 side-chain cleavage (P450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland.	Corticosterone	210-224	dopamine beta-hydroxylase	Rattus norvegicus	87-112
28737969-6	2017	Moreover, immobilization stress elevated the mRNA levels of tyrosine hydroxylase (Th), dopamine beta-hydroxylase (Dbh), and cytochrome P450 side-chain cleavage (P450scc), which are related to catecholamine and corticosterone synthesis in the adrenal gland.	Corticosterone	210-224	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	161-168
28089704-4	2017	MR expressed in abundance in this limbic-forebrain circuitry, is target of cortisol and corticosterone in modulation of appraisal processes, memory performance and selection of coping strategy.	Corticosterone	88-102	nuclear receptor subfamily 3 group C member 2	Homo sapiens	0-2
28089704-1	2017	We will highlight in honor of Randall Sakai the peculiar characteristics of the brain mineralocorticoid receptor (MR) in its response pattern to the classical mineralocorticoid aldosterone and the naturally occurring glucocorticoids corticosterone and cortisol.	Corticosterone	233-247	nuclear receptor subfamily 3 group C member 2	Homo sapiens	114-116
28899473-0	2017	[Effect of corticosterone on lissencephaly 1 expression in developing cerebral cortical neurons of fetal rats cultured in vitro].	Corticosterone	11-25	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1	Rattus norvegicus	29-44
28641395-8	2017	We speculate that the effectiveness of CRH uptake via these delivery methods and/or the duration and magnitude of the thyroxine and corticosterone response to CRH is not sufficient to have a substantial effect on hatching time.	Corticosterone	132-146	corticotropin releasing hormone	Gallus gallus	159-162
28554167-4	2017	Adult C57BL/6J male mice were treated with corticosterone (CORT; 25mg/L) for four weeks prior to paired-matings to generate F1 offspring.	Corticosterone	43-57	cortistatin	Mus musculus	59-63
28899473-1	2017	OBJECTIVE: To investigate the effect of corticosterone on the expression of the neuronal migration protein lissencephaly 1 (LIS1) in developing cerebral cortical neurons of fetal rats.	Corticosterone	40-54	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1	Rattus norvegicus	107-122
28899473-1	2017	OBJECTIVE: To investigate the effect of corticosterone on the expression of the neuronal migration protein lissencephaly 1 (LIS1) in developing cerebral cortical neurons of fetal rats.	Corticosterone	40-54	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1	Rattus norvegicus	124-128
28899473-9	2017	CONCLUSIONS: Corticosterone downregulates the expression of the neuronal migration protein LIS1 in developing cerebral cortical neurons of fetal rats cultured in vitro, and such effect depends on the concentration of corticosterone and duration of corticosterone intervention.	Corticosterone	13-27	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1	Rattus norvegicus	91-95
28899473-9	2017	CONCLUSIONS: Corticosterone downregulates the expression of the neuronal migration protein LIS1 in developing cerebral cortical neurons of fetal rats cultured in vitro, and such effect depends on the concentration of corticosterone and duration of corticosterone intervention.	Corticosterone	217-231	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1	Rattus norvegicus	91-95
28899473-9	2017	CONCLUSIONS: Corticosterone downregulates the expression of the neuronal migration protein LIS1 in developing cerebral cortical neurons of fetal rats cultured in vitro, and such effect depends on the concentration of corticosterone and duration of corticosterone intervention.	Corticosterone	248-262	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1	Rattus norvegicus	91-95
28808323-4	2017	Strikingly, extracellular corticosterone was sufficient to increase the trapping of GluN2B-NMDAR within synapses.	Corticosterone	26-40	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	84-90
28860968-4	2017	Following determination of an emotionality score, using complementary behavioral analysis of anxiety/depression across three different tests (Elevated Plus Maze, Novelty Suppressed Feeding, Splash Test), we showed that a 4-week corticosterone treatment (35 mug/ml, CORT model) in C57BL/6NTac male mice induced an anxiety/depressive-like behavior.	Corticosterone	228-242	cortistatin	Mus musculus	265-269
28808323-3	2017	Here, we demonstrate, using single molecule imaging and electrophysiological approaches in hippocampal neurons, that corticosterone specifically controls GluN2B-NMDAR surface dynamics and synaptic content through mineralocorticoid signalling.	Corticosterone	117-131	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	154-160
29203053-10	2017	CONCLUSIONS: These results showed that a higher level of circulation corticosterone by PFR in utero inhibited adrenal IGF1 signaling and steroidogenesis, whereas post-weaning HFD induced adrenal steroidogenesis by an enhanced IGF1 signaling.	Corticosterone	69-83	insulin-like growth factor 1	Rattus norvegicus	118-122
29203053-10	2017	CONCLUSIONS: These results showed that a higher level of circulation corticosterone by PFR in utero inhibited adrenal IGF1 signaling and steroidogenesis, whereas post-weaning HFD induced adrenal steroidogenesis by an enhanced IGF1 signaling.	Corticosterone	69-83	insulin-like growth factor 1	Rattus norvegicus	226-230
28618657-9	2017	Furthermore, Rg1 alleviated anhedonia and hopelessness, decreased serum corticosterone level, and increased serum testosterone level, and the GR protein level in the PFC and hippocampus of the CUMS-treated rats.	Corticosterone	72-86	protein phosphatase 1, regulatory subunit 3A	Mus musculus	13-16
28618657-10	2017	Moreover, Rg1 improved sleep disruption, down-regulated the serum corticosterone level, and increased AR protein level in the PFC of the GDX-treated mice.	Corticosterone	66-80	protein phosphatase 1, regulatory subunit 3A	Mus musculus	10-13
28808323-6	2017	These high-resolution imaging data unveiled that, in hippocampal networks, corticosterone is a natural, potent, fast and specific regulator of GluN2B-NMDAR membrane trafficking, tuning NMDAR-dependent synaptic adaptations.	Corticosterone	75-89	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	143-149
28337631-3	2017	In the present study, we aimed to investigate the corticosterone level in relation to anxiety-like behavior changes in transgenic male mice with different glial fibrillary acidic protein (GFAP)-ApoE isoforms.	Corticosterone	50-64	glial fibrillary acidic protein	Mus musculus	155-186
27886378-9	2017	However, PKA and P450scc were downregulated by lactate plus corticosterone treatment.	Corticosterone	60-74	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	17-24
28499147-11	2017	Our in vivo results support that fructose overload installs in EWAT conditions favoring glucocorticoid production through higher H6PD expression/activity supplying NADPH for enhanced 11 beta-HSD1 expression/activity, becoming this tissue a potential extra-adrenal source of corticosterone under these experimental conditions.	Corticosterone	274-288	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	129-133
28500787-3	2017	We have shown that exposure of mice to the stress hormone, corticosterone (CORT), and to diisopropyl fluorophosphate (DFP), as a nerve agent mimic, results in marked neuroinflammation, findings consistent with a stress/neuroimmune basis of GWI.	Corticosterone	59-73	cortistatin	Mus musculus	75-79
28403684-0	2017	Mangiferin prevents corticosterone-induced behavioural deficits via alleviation of oxido-nitrosative stress and down-regulation of indoleamine 2,3-dioxygenase (IDO) activity.	Corticosterone	20-34	indoleamine 2,3-dioxygenase 1	Mus musculus	131-158
28403684-9	2017	Western blotting analysis revealed that corticosterone administration significantly up-regulated the indoleamine 2,3-dioxygenase (IDO) protein expression level in the hippocampus which was significantly reduced by mangiferin treatment.	Corticosterone	40-54	indoleamine 2,3-dioxygenase 1	Mus musculus	101-128
28403684-9	2017	Western blotting analysis revealed that corticosterone administration significantly up-regulated the indoleamine 2,3-dioxygenase (IDO) protein expression level in the hippocampus which was significantly reduced by mangiferin treatment.	Corticosterone	40-54	indoleamine 2,3-dioxygenase 1	Mus musculus	130-133
28403684-10	2017	CONCLUSION: Taken together, our results suggest that mangiferin exerts anti-anxiety and antidepressant effect in corticosterone-treated rats, which is probably mediated through up-regulation of BDNF level along with inhibition of oxido-nitrosative stress, neuroinflammation and IDO up-regulation in the hippocampus region.	Corticosterone	113-127	brain-derived neurotrophic factor	Rattus norvegicus	194-198
28403684-10	2017	CONCLUSION: Taken together, our results suggest that mangiferin exerts anti-anxiety and antidepressant effect in corticosterone-treated rats, which is probably mediated through up-regulation of BDNF level along with inhibition of oxido-nitrosative stress, neuroinflammation and IDO up-regulation in the hippocampus region.	Corticosterone	113-127	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	278-281
28368424-10	2017	Preclinical inhibition of mTORC1 activity induces a marked reduction in tumor size, associated with induction of apoptosis and inhibition of proliferation that results in normalization of corticosterone plasma levels in AdTAg mice.	Corticosterone	188-202	CREB regulated transcription coactivator 1	Mus musculus	26-32
28343377-4	2017	The aim of the present study was designed to investigate the roles of corticosterone (CORT) on excitability of dorsal root ganglion (DRG) neurons innervating the stomach.	Corticosterone	70-84	cortistatin	Rattus norvegicus	86-90
28724737-1	2017	Glucocorticoid stress hormones, such as corticosterone (CORT), have profound effects on the behaviour and physiology of organisms, and thus have the potential to alter host competence and the contributions of individuals to population- and community-level pathogen dynamics.	Corticosterone	40-54	cortistatin	Homo sapiens	56-60
28720846-0	2017	Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons.	Corticosterone	29-43	Kruppel like factor 4	Rattus norvegicus	70-74
28720846-0	2017	Physiological stress-induced corticosterone increases heme uptake via KLF4-HCP1 signaling pathway in hippocampus neurons.	Corticosterone	29-43	solute carrier family 46 member 1	Rattus norvegicus	75-79
28337631-3	2017	In the present study, we aimed to investigate the corticosterone level in relation to anxiety-like behavior changes in transgenic male mice with different glial fibrillary acidic protein (GFAP)-ApoE isoforms.	Corticosterone	50-64	glial fibrillary acidic protein	Mus musculus	188-192
28337631-3	2017	In the present study, we aimed to investigate the corticosterone level in relation to anxiety-like behavior changes in transgenic male mice with different glial fibrillary acidic protein (GFAP)-ApoE isoforms.	Corticosterone	50-64	apolipoprotein E	Mus musculus	194-198
28542805-6	2017	RESULTS: Corticosterone dose dependently decreased CETP mRNA in THP-1 macrophages.	Corticosterone	9-23	cholesteryl ester transfer protein	Homo sapiens	51-55
28550455-8	2017	Then, we tested acute systemic LY2444296 in reducing anxiety- and depression-like behaviors, as well as releasing the stress hormone corticosterone (CORT), observed after chronic extended access (18 h/day for 14 days) cocaine self-administration.	Corticosterone	133-147	cortistatin	Rattus norvegicus	149-153
28542805-6	2017	RESULTS: Corticosterone dose dependently decreased CETP mRNA in THP-1 macrophages.	Corticosterone	9-23	GLI family zinc finger 2	Homo sapiens	64-69
28542805-7	2017	Corticosterone also decreased CETP mRNA expression after LXR pretreatment.	Corticosterone	0-14	cholesteryl ester transfer protein	Homo sapiens	30-34
27173157-7	2017	Our results showed that corticosterone decreases the phosphorylation of Akt and FoxO3a, leading to the nuclear localization of FoxO3a and the apoptosis of PC12 cells, while clozapine concentration dependently protected PC12 cells against corticosterone insult.	Corticosterone	238-252	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
28232027-4	2017	Here, we address this issue by elucidating the endogenous regulation of the transcription factor Kruppel-like factor 9 (klf9) across tissues during development by corticosteroid hormones (aldosterone and corticosterone) and their nuclear receptors (type-I and type-II receptors).	Corticosterone	204-218	Kruppel-like factor 9	Xenopus tropicalis	97-118
28232027-4	2017	Here, we address this issue by elucidating the endogenous regulation of the transcription factor Kruppel-like factor 9 (klf9) across tissues during development by corticosteroid hormones (aldosterone and corticosterone) and their nuclear receptors (type-I and type-II receptors).	Corticosterone	204-218	Kruppel-like factor 9	Xenopus tropicalis	120-124
28232027-10	2017	These results are consistent with previous in-vitro studies and indicate for the first time in-vivo that corticosteroid regulation of klf9 occurs exclusively via corticosterone and type-II receptor interaction across tissues.	Corticosterone	162-176	Kruppel-like factor 9	Xenopus tropicalis	134-138
28430981-7	2017	Administration of CNS GLP-1 increased fasting glucose, glucagon, corticosterone, and epinephrine and blunted insulin secretion in response to hyperglycemia.	Corticosterone	65-79	glucagon	Rattus norvegicus	22-27
27173157-0	2017	The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway.	Corticosterone	62-76	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
27173157-0	2017	The Atypical Antipsychotic Agent, Clozapine, Protects Against Corticosterone-Induced Death of PC12 Cells by Regulating the Akt/FoxO3a Signaling Pathway.	Corticosterone	62-76	forkhead box O3	Rattus norvegicus	127-133
27173157-7	2017	Our results showed that corticosterone decreases the phosphorylation of Akt and FoxO3a, leading to the nuclear localization of FoxO3a and the apoptosis of PC12 cells, while clozapine concentration dependently protected PC12 cells against corticosterone insult.	Corticosterone	24-38	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
27173157-7	2017	Our results showed that corticosterone decreases the phosphorylation of Akt and FoxO3a, leading to the nuclear localization of FoxO3a and the apoptosis of PC12 cells, while clozapine concentration dependently protected PC12 cells against corticosterone insult.	Corticosterone	24-38	forkhead box O3	Rattus norvegicus	80-86
27173157-7	2017	Our results showed that corticosterone decreases the phosphorylation of Akt and FoxO3a, leading to the nuclear localization of FoxO3a and the apoptosis of PC12 cells, while clozapine concentration dependently protected PC12 cells against corticosterone insult.	Corticosterone	24-38	forkhead box O3	Rattus norvegicus	127-133
27716949-2	2017	Levels of brain and/or plasma corticotropin-releasing hormone (CRH), beta-endorphin, ACTH and corticosterone (CORT) were enhanced by UVB.	Corticosterone	94-108	cortistatin	Mus musculus	110-114
28351560-1	2017	Neurons synthesizing corticotrophin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN) are activated during acute stress and act via the hypothalamic-pituitary-adrenal (HPA) axis to increase systemic levels of corticosterone (CORT).	Corticosterone	240-254	corticotropin releasing hormone	Mus musculus	21-53
28351560-1	2017	Neurons synthesizing corticotrophin-releasing hormone (CRH) in the paraventricular nucleus of the hypothalamus (PVN) are activated during acute stress and act via the hypothalamic-pituitary-adrenal (HPA) axis to increase systemic levels of corticosterone (CORT).	Corticosterone	240-254	corticotropin releasing hormone	Mus musculus	55-58
28487160-7	2017	On the other hand, the change in venom composition, measured as movement along the first principle component of venom phenotype space, was associated with baseline corticosterone (CORT) levels in the snakes.	Corticosterone	164-178	cortistatin	Homo sapiens	180-184
28654010-6	2017	Plasma levels of corticosterone (CORT) were measured following restraint stress or no-stress (control) in virgin rats and postpartum rats housed with their pups or with pup removal for different periods of time of one hour, 24 h, or eight days.	Corticosterone	17-31	cortistatin	Rattus norvegicus	33-37
28694701-10	2017	Moreover, positive relationships were observed between Nesfatin-1 levels and the concentrations of corticosterone (r=0.626, P&lt;0.001) and TSH (r=0.229, P=0.036) in depressed patients with SCH.	Corticosterone	99-113	nucleobindin 2	Homo sapiens	55-65
28295336-10	2017	These likely include PPNPY expressing catecholaminergic neurons projecting to vasopressinergic and corticotrophin releasing factor neurons in the paraventricular nucleus, which when activated result in elevated plasma vasopressin and corticosterone.	Corticosterone	234-248	arginine vasopressin	Rattus norvegicus	78-89
28404850-5	2017	Both sensory trigeminal ganglion (TG) and sympathetic superior cervical ganglion (SCG) neurons expressed adrenergic receptors (activated by epinephrine) and the glucocorticoid receptor (activated by corticosterone).	Corticosterone	199-213	nuclear receptor subfamily 3 group C member 1	Homo sapiens	161-184
28288898-6	2017	We also identified that corticosterone administration significantly altered the expression of the key microglial complement receptor, CD11b after stroke.	Corticosterone	24-38	integrin subunit alpha M	Homo sapiens	134-139
28242047-8	2017	Upon injection with adrenocorticotropic hormone, control-treated apoA1 knockout mice already showed only a mild increase in plasma corticosterone levels, indicative of relative glucocorticoid insufficiency.	Corticosterone	131-145	apolipoprotein A-I	Mus musculus	65-70
27173157-10	2017	Western blot analyses revealed that clozapine induced the phosphorylation of Akt and FoxO3a by the PI3K/Akt pathway and reversed the reduction of the phosphorylated Akt and FoxO3a and the nuclear translocation of FoxO3a evoked by corticosterone.	Corticosterone	230-244	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
27173157-10	2017	Western blot analyses revealed that clozapine induced the phosphorylation of Akt and FoxO3a by the PI3K/Akt pathway and reversed the reduction of the phosphorylated Akt and FoxO3a and the nuclear translocation of FoxO3a evoked by corticosterone.	Corticosterone	230-244	forkhead box O3	Rattus norvegicus	85-91
27173157-11	2017	Together, our data indicates that clozapine protects PC12 cells against corticosterone-induced cell death by modulating activity of the PI3K/Akt/FoxO3a pathway.	Corticosterone	72-86	AKT serine/threonine kinase 1	Rattus norvegicus	141-144
27173157-11	2017	Together, our data indicates that clozapine protects PC12 cells against corticosterone-induced cell death by modulating activity of the PI3K/Akt/FoxO3a pathway.	Corticosterone	72-86	forkhead box O3	Rattus norvegicus	145-151
28186389-0	2017	The role of 5-HT2c receptor on corticosterone-mediated food intake.	Corticosterone	31-45	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	12-27
28186389-5	2017	Administration of the 5-HT2c receptor agonist m-chlorophenylpiperazin (mCPP) reversed the effect of corticosterone on food intake.	Corticosterone	100-114	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	22-37
28186389-6	2017	The anorectic effects of mCPP were also blocked by the 5-HT2c receptor antagonist RS102221 in corticosterone-treated mice.	Corticosterone	94-108	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	55-70
28820392-0	2017	Orally administered angiotensin-converting enzyme-inhibitors captopril and isoleucine-proline-proline have distinct effects on local renin-angiotensin system and corticosterone synthesis in dextran sulfate sodium-induced colitis in mice.	Corticosterone	162-176	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	20-49
28186389-7	2017	Both corticosterone and mCPP increased c-Fos expression in hypothalamic nuclei, but not the nucleus of the solitary tract.	Corticosterone	5-19	FBJ osteosarcoma oncogene	Mus musculus	39-44
28302445-11	2017	Stressed mice have also shown a significant high serum corticosterone (CORT) and low BDNF level.	Corticosterone	55-69	cortistatin	Mus musculus	71-75
28263830-5	2017	After six consecutive days of corticosterone administration, CRH-R1 transcription was downregulated in hypothalamic and cerebellar regions and hypometabolic changes were observed in mice treated with the higher dose for several limbic and sensorimotor circuitries, notably basal ganglia, deep cerebellar nuclei, and red nucleus.	Corticosterone	30-44	corticotropin releasing hormone receptor 1	Mus musculus	61-67
28951828-7	2017	MAJOR CONCLUSIONS: Leptin exerts a plethora of metabolic effects on various tissues including suppressing production of glucagon and corticosterone, increasing glucose uptake, and inhibiting hepatic glucose output.	Corticosterone	133-147	leptin	Homo sapiens	19-25
28515473-0	2017	Placental O-GlcNAc-transferase expression and interactions with the glucocorticoid receptor are sex specific and regulated by maternal corticosterone exposure in mice.	Corticosterone	135-149	nuclear receptor subfamily 3, group C, member 1	Mus musculus	68-91
28487303-4	2017	The consequent cortisol deficiency results in a compensatory increase in adrenocorticotropic hormone (ACTH) drive, which stimulates the production of deoxycorticosterone and corticosterone leading to hypertension and hypokalaemia.	Corticosterone	155-169	proopiomelanocortin	Homo sapiens	73-100
28487303-4	2017	The consequent cortisol deficiency results in a compensatory increase in adrenocorticotropic hormone (ACTH) drive, which stimulates the production of deoxycorticosterone and corticosterone leading to hypertension and hypokalaemia.	Corticosterone	155-169	proopiomelanocortin	Homo sapiens	102-106
28533747-2	2017	Stress or orexin administration stimulates hyperarousal, adrenocorticotropic hormone (ACTH) and corticosterone release, and selective OX1R blockade can attenuate several stress-induced behavioral and cardiovascular responses but not the hypothalamic-pituitary-adrenal (HPA) axis activation.	Corticosterone	96-110	hypocretin	Mus musculus	10-16
28189567-10	2017	The expression levels of the glucocorticoid receptor (GR) in the hypothalamus and several genes in the adrenal glands were correlated with the post-stress levels of corticosterone in plasma.	Corticosterone	165-179	nuclear receptor subfamily 3 group C member 1	Gallus gallus	29-52
28189567-10	2017	The expression levels of the glucocorticoid receptor (GR) in the hypothalamus and several genes in the adrenal glands were correlated with the post-stress levels of corticosterone in plasma.	Corticosterone	165-179	nuclear receptor subfamily 3 group C member 1	Gallus gallus	54-56
28189567-15	2017	The previously found QTL for corticosterone was associated with GR expression in hypothalamus.	Corticosterone	29-43	nuclear receptor subfamily 3 group C member 1	Gallus gallus	64-66
28196601-7	2017	Physiological levels of corticosterone promote HSC migration via the GC receptor Nr3c1-dependent signaling and upregulation of actin-organizing molecules.	Corticosterone	24-38	nuclear receptor subfamily 3, group C, member 1	Mus musculus	81-86
28515684-9	2017	After the FST, CD157 KO mice showed decreases in striatal and hippocampal serotonin (5-HT) content, cortical norepinephrine (NE) content, and plasma corticosterone concentration.	Corticosterone	149-163	bone marrow stromal cell antigen 1	Mus musculus	15-20
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	Corticosterone	95-109	solute carrier family 22 member 3	Rattus norvegicus	0-28
27659446-1	2017	Organic cation transporter 3 (OCT3) is a high-capacity, low-affinity transporter that mediates corticosterone-sensitive uptake of monoamines including norepinephrine, epinephrine, dopamine, histamine and serotonin.	Corticosterone	95-109	solute carrier family 22 member 3	Rattus norvegicus	30-34
28324022-4	2017	From P14, there was a nocturnal acrophase of corticosterone at ZT20, which was associated with pups" eye opening.	Corticosterone	45-59	S100 calcium binding protein A9	Rattus norvegicus	5-8
28118407-2	2017	Besides H2S production rate and protein expressions of H2S-related synthases cystathionine beta-synthase (CBS), 3-mercaptopyruvate sulfurtransferase (3-MPST) and cystathionine gamma-lyase (CSE) in the POA, we also measured deep body temperature (Tb), circulating plasma levels of cytokines and corticosterone in an animal model of systemic inflammation.	Corticosterone	294-308	mercaptopyruvate sulfurtransferase	Rattus norvegicus	112-148
28324022-7	2017	In all postnatal ages, Per2 and Cry1 circadian profiles were synchronized in phase with the circadian rhythm of plasma corticosterone, whereas Bmal1 was in antiphase.	Corticosterone	119-133	cryptochrome circadian regulator 1	Rattus norvegicus	32-36
28565823-0	2017	Corticosterone suppresses IL-1beta-induced mPGE2 expression through regulation of the 11beta-HSD1 bioactivity of synovial fibroblasts in vitro.	Corticosterone	0-14	interleukin 1 beta	Rattus norvegicus	26-34
28565823-0	2017	Corticosterone suppresses IL-1beta-induced mPGE2 expression through regulation of the 11beta-HSD1 bioactivity of synovial fibroblasts in vitro.	Corticosterone	0-14	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	86-97
28565823-6	2017	Corticosterone was demonstrated to suppress the mRNA expression levels of inflammatory factors, such as TNF-alpha and PGE2, induced by IL-1beta in vitro.	Corticosterone	0-14	tumor necrosis factor	Rattus norvegicus	104-113
28565823-6	2017	Corticosterone was demonstrated to suppress the mRNA expression levels of inflammatory factors, such as TNF-alpha and PGE2, induced by IL-1beta in vitro.	Corticosterone	0-14	interleukin 1 beta	Rattus norvegicus	135-143
28565823-8	2017	Cortisol concentration in the medium of the group treated with corticosterone was significantly increased (P&lt;0.05) compared with that of the control group; however, the cortisol concentration was decreased in the medium when the conversion bioactivity of 11beta-HSD1 was inhibited by PF915275, while the changes in 11beta-HSD1 and mPGES-1 mRNA expression levels and PGE2 content were reversed in the medium.	Corticosterone	63-77	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	258-269
28565823-8	2017	Cortisol concentration in the medium of the group treated with corticosterone was significantly increased (P&lt;0.05) compared with that of the control group; however, the cortisol concentration was decreased in the medium when the conversion bioactivity of 11beta-HSD1 was inhibited by PF915275, while the changes in 11beta-HSD1 and mPGES-1 mRNA expression levels and PGE2 content were reversed in the medium.	Corticosterone	63-77	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	318-329
28565823-8	2017	Cortisol concentration in the medium of the group treated with corticosterone was significantly increased (P&lt;0.05) compared with that of the control group; however, the cortisol concentration was decreased in the medium when the conversion bioactivity of 11beta-HSD1 was inhibited by PF915275, while the changes in 11beta-HSD1 and mPGES-1 mRNA expression levels and PGE2 content were reversed in the medium.	Corticosterone	63-77	prostaglandin E synthase	Mus musculus	334-341
28137450-10	2017	Full rescue of wild-type-like corticosterone and GR circadian rhythm and level in CRF1-/- mice by exogenous corticosterone does not affect CRF1 receptor-dependent cocaine reward but induces stereotypy responses to cocaine.	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 1	Mus musculus	49-51
28190867-2	2017	These reactions comprise a hydroxylation at position C11 of the steroid intermediate deoxycorticosterone yielding corticosterone, followed by a hydroxylation at position C18 yielding 18-hydroxy-corticosterone and a subsequent oxidation of the hydroxyl group at C18, which results in the formation of aldosterone.	Corticosterone	90-104	aldo-keto reductase family 1 member C4	Homo sapiens	53-56
28190867-2	2017	These reactions comprise a hydroxylation at position C11 of the steroid intermediate deoxycorticosterone yielding corticosterone, followed by a hydroxylation at position C18 yielding 18-hydroxy-corticosterone and a subsequent oxidation of the hydroxyl group at C18, which results in the formation of aldosterone.	Corticosterone	90-104	Bardet-Biedl syndrome 9	Homo sapiens	261-264
28314819-5	2017	Depressive-like behaviors induced by chronic social defeat stress or administration of corticosterone (CORT) were significantly ameliorated in Nox1-/Y Generation of ROS was significantly elevated in the prefrontal cortex (PFC) of mice administrated with CORT, while NOX1 mRNA was upregulated only in the ventral tegmental area (VTA) among brain areas responsible for emotional behaviors.	Corticosterone	87-101	NADPH oxidase 1	Mus musculus	143-147
28314819-5	2017	Depressive-like behaviors induced by chronic social defeat stress or administration of corticosterone (CORT) were significantly ameliorated in Nox1-/Y Generation of ROS was significantly elevated in the prefrontal cortex (PFC) of mice administrated with CORT, while NOX1 mRNA was upregulated only in the ventral tegmental area (VTA) among brain areas responsible for emotional behaviors.	Corticosterone	87-101	NADPH oxidase 1	Mus musculus	266-270
28314819-5	2017	Depressive-like behaviors induced by chronic social defeat stress or administration of corticosterone (CORT) were significantly ameliorated in Nox1-/Y Generation of ROS was significantly elevated in the prefrontal cortex (PFC) of mice administrated with CORT, while NOX1 mRNA was upregulated only in the ventral tegmental area (VTA) among brain areas responsible for emotional behaviors.	Corticosterone	103-107	NADPH oxidase 1	Mus musculus	143-147
28314819-5	2017	Depressive-like behaviors induced by chronic social defeat stress or administration of corticosterone (CORT) were significantly ameliorated in Nox1-/Y Generation of ROS was significantly elevated in the prefrontal cortex (PFC) of mice administrated with CORT, while NOX1 mRNA was upregulated only in the ventral tegmental area (VTA) among brain areas responsible for emotional behaviors.	Corticosterone	103-107	NADPH oxidase 1	Mus musculus	266-270
28393871-5	2017	We found that SSB significantly promoted social aggression, accompanied by heightened serum corticosterone and reduced body weight.	Corticosterone	92-106	Sjogren syndrome antigen B	Mus musculus	14-17
28376115-3	2017	We examined whether Sgk1 expression in adult rat brain white matter is increased by acute stress-induced elevations in endogenous corticosterone and whether it fluctuates with diurnal variations in corticosterone.	Corticosterone	130-144	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	20-24
28376115-6	2017	Corticosterone treatment of adrenalectomized rats also rapidly increased corpus callosum Sgk1 mRNA.	Corticosterone	0-14	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	89-93
28376115-9	2017	These results indicate a unique sensitivity of oligodendrocyte Sgk1 expression to activity-dependent fluctuations in corticosterone hormone secretion, and raises the prospect that hypothalamic-pituitary-adrenal axis dysregulation or glucocorticoid pharmacotherapy may compromise the normal activity-dependent interactions between oligodendrocytes and neurons.	Corticosterone	117-131	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	63-67
26673869-2	2017	Here, we review recent evidence for several factors that influence plasma concentrations of corticosterone (CORT), the main GC in tuatara (Sphenodon punctatus), and discuss the application of CORT as a physiological tool to monitor conservation efforts.	Corticosterone	92-106	cortistatin	Rattus norvegicus	108-112
28082245-1	2017	It is well established that corticosterone (CORT) enhances memory consolidation of emotionally arousing experiences.	Corticosterone	28-42	cortistatin	Rattus norvegicus	44-48
28061324-8	2017	In addition, there were striking increases in both citrate synthase gene expression and enzymatic activity in skeletal muscle of mice in the corticosterone group relative to vehicle control.	Corticosterone	141-155	citrate synthase	Mus musculus	51-67
27780724-7	2017	In the present study, in an Open Field test, intraperitoneal bicuculline methiodide blocked anxiogenic-like behavior as well as the increase in plasma ACTH and corticosterone levels induced by ghrelin (30pmol) in neonatal chicks.	Corticosterone	160-174	ghrelin/obestatin prepropeptide	Gallus gallus	193-200
28039067-0	2017	Prenatal betaine exposure alleviates corticosterone-induced inhibition of CYP27A1 expression in the liver of juvenile chickens associated with its promoter DNA methylation.	Corticosterone	37-51	cytochrome P450 family 27 subfamily A member 1	Gallus gallus	74-81
28185964-7	2017	In addition, corticosterone (CORT) level in serum, 5-hydroxytryptamine (5-HT) and 5-HT2A receptor (5-HT2AR) expressions in prefrontal cortex (PFC), hippocampal CA1 and dentate gyrus (DG) areas were measured on the 35th day to elucidate the mechanism(s) by which the exacerbation occurred.	Corticosterone	13-27	carbonic anhydrase 1	Rattus norvegicus	160-163
28185964-7	2017	In addition, corticosterone (CORT) level in serum, 5-hydroxytryptamine (5-HT) and 5-HT2A receptor (5-HT2AR) expressions in prefrontal cortex (PFC), hippocampal CA1 and dentate gyrus (DG) areas were measured on the 35th day to elucidate the mechanism(s) by which the exacerbation occurred.	Corticosterone	29-33	carbonic anhydrase 1	Rattus norvegicus	160-163
28131845-5	2017	Pre-treatment with the glucocorticoid receptor antagonist RU486 attenuated the effect of corticosterone on swelling at 24h, but not that of 5alphaTHB.	Corticosterone	89-103	nuclear receptor subfamily 3, group C, member 1	Mus musculus	23-46
28013041-2	2017	Blood corticosterone concentrations are proportionally increased with catalase and glutathione-peroxidase activity and are inversely proportional with 3-nitrotyrosine concentrations.Cytochrome c oxidase, adenosin tryphosphatase and monoamine oxidase activities of CA3 hippocampal field mark a stress-time dependent decrease.	Corticosterone	6-20	catalase	Rattus norvegicus	70-78
28013041-2	2017	Blood corticosterone concentrations are proportionally increased with catalase and glutathione-peroxidase activity and are inversely proportional with 3-nitrotyrosine concentrations.Cytochrome c oxidase, adenosin tryphosphatase and monoamine oxidase activities of CA3 hippocampal field mark a stress-time dependent decrease.	Corticosterone	6-20	carbonic anhydrase 3	Rattus norvegicus	264-267
28337713-13	2017	Moreover, FGF21 acts on the hypothalamus to release corticosterone and induces in adipocytes the production of adiponectin, an adipokine with antihypertensive activities.	Corticosterone	52-66	fibroblast growth factor 21	Homo sapiens	10-15
28287792-5	2017	Here, we describe the effects of chronic corticosterone administration (CORT) on female mice, a procedure known to enhance behavioral emotionality in male mice.	Corticosterone	41-55	cortistatin	Mus musculus	72-76
28151031-2	2017	Bovine lactoferrin (bLf) has been shown to modulate intestinal immunity and endogenous corticosterone.	Corticosterone	87-101	lactotransferrin	Bos taurus	7-18
28464077-6	2017	The results indicated that production of corticosterone (CORT) and reactive oxygen species (ROS) increased significantly after transportation ( &lt; 0.05).	Corticosterone	41-55	CORT	Gallus gallus	57-61
28034915-8	2017	Analysis of Abx-treated CD4+ T cell donors showed systemically elevated levels of the stress hormone corticosterone throughout life compared with untreated donors.	Corticosterone	101-115	CD4 antigen	Mus musculus	24-27
28034915-10	2017	Thus, our results suggest that early-life Abx treatment results in a stress response with high levels of corticosterone that influences CD4+ T cell function.	Corticosterone	105-119	CD4 antigen	Mus musculus	136-139
27979380-0	2017	Central administration of neuropeptide Y differentially regulates monoamines and corticosterone in heat-exposed fed and fasted chicks.	Corticosterone	81-95	neuropeptide Y	Homo sapiens	26-40
27979380-9	2017	Furthermore, NPY significantly reduced plasma corticosterone concentrations in fasted chicks.	Corticosterone	46-60	neuropeptide Y	Homo sapiens	13-16
27979380-11	2017	In conclusion, brain NPY may attenuate the reduction of food intake during heat stress and the increased brain NPY might be a potential regulator of the monoamines and corticosterone to modulate stress response in heat-exposed chicks.	Corticosterone	168-182	neuropeptide Y	Homo sapiens	111-114
27648697-0	2017	Interleukin-18 Reduces Blood Glucose and Modulates Plasma Corticosterone in a Septic Mouse Model.	Corticosterone	58-72	interleukin 18	Mus musculus	0-14
27648697-11	2017	Additionally, corticosterone levels were higher after CLP in the presence of either endogenous or exogenous IL-18.	Corticosterone	14-28	interleukin 18	Mus musculus	108-113
28034777-9	2017	Lastly, we were able to reduce NE uptake in isolated brown adipocytes in an in vitro culture by adding corticosterone which is a known OCT3-blocker.	Corticosterone	103-117	OCTN3	Homo sapiens	135-139
28275717-1	2017	Variations in circulating corticosterone (Cort) are driven by the paraventricular nucleus of the hypothalamus (PVN), mainly via the sympathetic autonomic nervous system (ANS) directly stimulating Cort release from the adrenal gland and via corticotropin-releasing hormone targeting the adenohypophysis to release adrenocorticotropic hormone (ACTH).	Corticosterone	26-40	corticotropin releasing hormone	Rattus norvegicus	240-271
28275717-1	2017	Variations in circulating corticosterone (Cort) are driven by the paraventricular nucleus of the hypothalamus (PVN), mainly via the sympathetic autonomic nervous system (ANS) directly stimulating Cort release from the adrenal gland and via corticotropin-releasing hormone targeting the adenohypophysis to release adrenocorticotropic hormone (ACTH).	Corticosterone	42-46	corticotropin releasing hormone	Rattus norvegicus	240-271
28063130-1	2017	PURPOSE: Corticosterone prevents cold-induced stimulation of thyrotropin-releasing hormone (Trh) expression in rats, and the stimulatory effect of dibutyryl cyclic-adenosine monophosphate (dB-cAMP) on Trh transcription in hypothalamic cultures.	Corticosterone	9-23	thyrotropin releasing hormone	Rattus norvegicus	61-90
28069523-2	2017	We tested the hypothesis that a three week administration of stress-associated levels of corticosterone (CORT, the principal rodent glucocorticoid) would increase systemic and CNS DNA and RNA damage from oxidation; a phenomenon known to be centrally involved in the aging process.	Corticosterone	89-103	cortistatin	Rattus norvegicus	105-109
28096435-9	2017	Modulating glucocorticoid receptor (GR) activity did not alter aldosterone production by ZG cells; however, altering GR activity did modify corticosterone production from ZF/ZR/ZR cells both basally and in response to adrenocorticotropic hormone (ACTH).	Corticosterone	140-154	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	117-119
28096435-10	2017	Additionally, activating the MR in ZF/ZR/ZR cells strikingly reduced corticosterone secretion.	Corticosterone	69-83	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	29-31
27240530-3	2017	The glucocorticoid receptor (GR) is the major receptor for the stress hormone cortisol (corticosterone in rodents) and is widely expressed in excitatory and inhibitory neurons, as well as in glial cells.	Corticosterone	88-102	nuclear receptor subfamily 3, group C, member 1	Mus musculus	4-27
27240530-3	2017	The glucocorticoid receptor (GR) is the major receptor for the stress hormone cortisol (corticosterone in rodents) and is widely expressed in excitatory and inhibitory neurons, as well as in glial cells.	Corticosterone	88-102	nuclear receptor subfamily 3, group C, member 1	Mus musculus	29-31
27908768-6	2017	Acute restraint stress attenuated the excitatory effect of Kv7 blocker XE-991 on the firing activity of PVN-CRH neurons and blunted the increase in plasma corticosterone (CORT) levels induced by microinjection of XE-991 into the PVN.	Corticosterone	155-169	cortistatin	Rattus norvegicus	171-175
28064086-0	2017	Forced swimming-induced oxytocin release into blood and brain: Effects of adrenalectomy and corticosterone treatment.	Corticosterone	92-106	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	24-32
28064086-2	2017	Certain stressors are known to cause the simultaneous release of OXT and adrenocorticotrophic hormone (ACTH) followed by corticosterone (CORT).	Corticosterone	121-135	cortistatin	Rattus norvegicus	137-141
27941304-0	2017	Lactoferrin ameliorates corticosterone-related acute stress and hyperglycemia in rats.	Corticosterone	24-38	lactotransferrin	Rattus norvegicus	0-11
28057718-9	2017	Furthermore, corticosterone administration induced JNK and c-Src activation, TJ disruption and protein thiol oxidation in colonic mucosa.	Corticosterone	13-27	mitogen-activated protein kinase 8	Homo sapiens	51-54
28057718-9	2017	Furthermore, corticosterone administration induced JNK and c-Src activation, TJ disruption and protein thiol oxidation in colonic mucosa.	Corticosterone	13-27	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	59-64
27974436-10	2017	SERPINA10 had an expression QTL (eQTL) colocalized with the corticosterone QTL on chromosome 5 and PDE1C had an eQTL colocalized with the aldosterone QTL on chromosome 2.	Corticosterone	60-74	serpin family A member 10	Gallus gallus	0-9
26342748-5	2017	We found that both PAE and PS dams had higher corticosterone (CORT) levels than control dams.	Corticosterone	46-60	cortistatin	Homo sapiens	62-66
28210212-3	2017	Here we address this issue by examining the effects of chronic exposure to the stress hormone, corticosterone (CORT), in both adolescent and adult animals.	Corticosterone	95-109	cortistatin	Rattus norvegicus	111-115
26934364-8	2017	CONCLUSION: These results demonstrates that hypertension and insulin resistance induced by COC is associated with increased cardiac RAS and PAI-1 gene expression, which is likely to be through corticosterone-dependent but not aldosterone-dependent mechanism.	Corticosterone	193-207	serpin family E member 1	Rattus norvegicus	140-145
28112679-3	2017	Leptin infusion reduced rates of lipolysis, hepatic glucose production (HGP), and hepatic ketogenesis by 50% within 6 hours and were independent of any changes in plasma glucagon concentrations; these effects were abrogated by coinfusion of corticosterone.	Corticosterone	241-255	leptin	Rattus norvegicus	0-6
28112679-4	2017	Treating leptin- and corticosterone-infused rats with an adipose triglyceride lipase inhibitor blocked corticosterone-induced increases in plasma glucose concentrations and rates of HGP and ketogenesis.	Corticosterone	103-117	leptin	Rattus norvegicus	9-15
28112679-7	2017	In contrast, the chronic glucose-lowering effect of leptin in a STZ-induced mouse model of poorly controlled T1D was associated with decreased food intake, reduced plasma glucagon and corticosterone concentrations, and decreased ectopic lipid (triacylglycerol/diacylglycerol) content in liver and muscle.	Corticosterone	184-198	leptin	Mus musculus	52-58
27001616-5	2017	In contrast, a high-dose of MAGL inhibitors produces pro- or antidepressant effects on acute stress- or chronic corticosterone-exposed mice, respectively, through GABAergic synaptic disinhibition.	Corticosterone	112-126	monoglyceride lipase	Mus musculus	28-32
27001616-9	2017	We propose that depression-like behavior of animals in response to acute stress is the normal behavioral response, and thus, MAGL inhibitors, which produce antidepressant effects in chronic corticosterone-exposed animals through GABAergic synaptic disinhibition, represent a new class of rapidly-acting and long-lasting antidepressants.	Corticosterone	190-204	monoglyceride lipase	Mus musculus	125-129
27604564-0	2017	Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3.	Corticosterone	0-14	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	132-160
27604564-2	2017	We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking following self-administration in rats and that this potentiation appears to involve corticosterone-induced blockade of dopamine clearance via the organic cation transporter 3 (OCT3).	Corticosterone	209-223	solute carrier family 22 member 3	Rattus norvegicus	271-299
27604564-2	2017	We previously reported that stress, via elevated corticosterone, potentiates cocaine-primed reinstatement of cocaine seeking following self-administration in rats and that this potentiation appears to involve corticosterone-induced blockade of dopamine clearance via the organic cation transporter 3 (OCT3).	Corticosterone	209-223	solute carrier family 22 member 3	Rattus norvegicus	301-305
27604564-3	2017	In the present study, we use a conditioned place preference/reinstatement paradigm in mice to directly test the hypothesis that corticosterone potentiates cocaine-primed reinstatement by blockade of OCT3.	Corticosterone	128-142	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	199-203
27604564-10	2017	Together, these data provide the first direct evidence that the interaction of corticosterone with OCT3 mediates corticosterone effects on drug-seeking behavior and establish OCT3 function as an important determinant of susceptibility to cocaine use.	Corticosterone	79-93	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	99-103
27604564-10	2017	Together, these data provide the first direct evidence that the interaction of corticosterone with OCT3 mediates corticosterone effects on drug-seeking behavior and establish OCT3 function as an important determinant of susceptibility to cocaine use.	Corticosterone	113-127	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	99-103
27789312-0	2017	PPARbeta/delta activation protects against corticosterone-induced ER stress in astrocytes by inhibiting the CpG hypermethylation of microRNA-181a.	Corticosterone	43-57	peroxisome proliferator-activated receptor delta	Rattus norvegicus	0-8
27789312-5	2017	Our research found that corticosterone treatment resulted in astrocyte damage and reduced the expression of PPARbeta/delta.	Corticosterone	24-38	peroxisome proliferator-activated receptor delta	Rattus norvegicus	108-116
27789312-9	2017	Finally, we demonstrated that PPARbeta/delta activation by GW0742 noticeably inhibited the activities and expression of DNA methyltransferases, and reduced the corticosterone-induced CpG island hypermethylation of microRNA-181a1 in astrocytes.	Corticosterone	160-174	peroxisome proliferator-activated receptor delta	Rattus norvegicus	30-38
27988398-22	2017	SOCG increased cell viability in corticosterone treated PC12 cells, which was accompanied by decreased caspase-3 expression and the ratio of Bax/Bcl-2 mRNA expression as well as increased BDNF expression in vitro.	Corticosterone	33-47	caspase 3	Rattus norvegicus	103-112
27988398-22	2017	SOCG increased cell viability in corticosterone treated PC12 cells, which was accompanied by decreased caspase-3 expression and the ratio of Bax/Bcl-2 mRNA expression as well as increased BDNF expression in vitro.	Corticosterone	33-47	BCL2 associated X, apoptosis regulator	Rattus norvegicus	141-144
27988398-22	2017	SOCG increased cell viability in corticosterone treated PC12 cells, which was accompanied by decreased caspase-3 expression and the ratio of Bax/Bcl-2 mRNA expression as well as increased BDNF expression in vitro.	Corticosterone	33-47	BCL2, apoptosis regulator	Rattus norvegicus	145-150
27988398-22	2017	SOCG increased cell viability in corticosterone treated PC12 cells, which was accompanied by decreased caspase-3 expression and the ratio of Bax/Bcl-2 mRNA expression as well as increased BDNF expression in vitro.	Corticosterone	33-47	brain-derived neurotrophic factor	Rattus norvegicus	188-192
28071711-4	2017	Here, we show that both wild-type and Per3-/- mice showed elevated levels of circulating corticosterone and increased hippocampal Bdnf expression after 3 weeks of exposure to dim light at night, but only mice deficient for the PERIOD3 protein (Per3-/-) exhibited a transient anhedonia-like phenotype, observed as reduced sucrose preference, in weeks 2-3 of dim light at night, whereas WT mice did not.	Corticosterone	89-103	period circadian clock 3	Mus musculus	38-42
28174689-5	2017	Next, we performed drug inhibition assays and identified interspecies differences in the pharmacological properties of polyspecific monoamine transporters; in particular, corticosterone and decynium-22, which are widely recognized as typical inhibitors of human OCT3, enhanced the transport activity of mouse Oct3.	Corticosterone	171-185	solute carrier family 22 member 3	Homo sapiens	262-266
28174689-5	2017	Next, we performed drug inhibition assays and identified interspecies differences in the pharmacological properties of polyspecific monoamine transporters; in particular, corticosterone and decynium-22, which are widely recognized as typical inhibitors of human OCT3, enhanced the transport activity of mouse Oct3.	Corticosterone	171-185	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	309-313
27769714-2	2017	Pulsatile corticosterone replacement in adrenalectomised rats resulted in different dynamics of Sgk1 mRNA production, with a distinct pulsatile mRNA induction profile observed in the pituitary in contrast to a non-pulsatile induction in the prefrontal cortex (PFC).	Corticosterone	10-24	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	96-100
27789393-4	2017	Luman-deficient mice exhibited a blunted stress response characterized by low levels of both anxiety and depressive-like behaviour in addition to low circulating corticosterone levels.	Corticosterone	162-176	cAMP responsive element binding protein 3	Mus musculus	0-5
27485250-0	2016	Premature mammary gland involution with repeated corticosterone injection in interleukin 10-deficient mice.	Corticosterone	49-63	interleukin 10	Mus musculus	77-91
27876634-7	2017	Nonetheless, IFN-gamma did synergistically interact with acute restraint stress to increase plasma corticosterone concentrations, and this effect was most pronounced in the male mice.	Corticosterone	99-113	interferon gamma	Mus musculus	13-22
27876634-8	2017	These data are among the first to show that systemically administered IFN-gamma can alone or in conjunction with psychologically relevant stressor, modify brain regional monoamine activity and the plasma corticosterone response.	Corticosterone	204-218	interferon gamma	Mus musculus	70-79
28848078-6	2017	Cur/SLNs-HU-211 improved CB1 expression and inspired the proliferation of astrocytes in the hippocampus and striatum, exerted neuroprotective effects by preventing corticosterone -induced BDNF/NeuN expression reduction.	Corticosterone	164-178	brain-derived neurotrophic factor	Rattus norvegicus	188-192
28848078-6	2017	Cur/SLNs-HU-211 improved CB1 expression and inspired the proliferation of astrocytes in the hippocampus and striatum, exerted neuroprotective effects by preventing corticosterone -induced BDNF/NeuN expression reduction.	Corticosterone	164-178	RNA binding fox-1 homolog 3	Rattus norvegicus	193-197
27906551-6	2017	In rodent models with either chronic infusion of ACTH or acute restraint stress-induced ACTH, corticosterone levels were significantly reduced by ALD1613.	Corticosterone	94-108	pro-opiomelanocortin-alpha	Mus musculus	49-53
27906551-6	2017	In rodent models with either chronic infusion of ACTH or acute restraint stress-induced ACTH, corticosterone levels were significantly reduced by ALD1613.	Corticosterone	94-108	pro-opiomelanocortin-alpha	Mus musculus	88-92
28852406-4	2017	Knockdown of microRNA using Dicer1 siRNA in H295R adrenocortical cells increased levels of CYP11A1, CYP21A1, and CYP17A1 mRNA and the secretion of cortisol, corticosterone, 11-deoxycorticosterone, 18-hydroxycorticosterone, and aldosterone.	Corticosterone	157-171	dicer 1, ribonuclease III	Homo sapiens	28-34
27754933-1	2017	Maternal stress can impair foetal development and program sex-specific disease outcomes in offspring through the actions of maternally produced glucocorticoids, predominantly corticosterone (Cort) in rodents.	Corticosterone	175-189	cortistatin	Mus musculus	191-195
28252602-0	2017	[Corticosterone-induced changes in the inhibitory neurotransmission in hippocampal CA1 synapses depending on the activity of inhibitory synapses that express cannabinoid receptors].	Corticosterone	1-15	carbonic anhydrase 1	Rattus norvegicus	83-86
28252602-1	2017	AIM: To study an effect of corticosterone (100 nM) on spontaneous inhibitory postsynaptic currents (sIPSC) in pyramidal neurons of CA1 area and a role of inhibitory CB1-expressing synapses in the development of corticosterone-induced effects.	Corticosterone	27-41	carbonic anhydrase 1	Rattus norvegicus	131-134
28252602-1	2017	AIM: To study an effect of corticosterone (100 nM) on spontaneous inhibitory postsynaptic currents (sIPSC) in pyramidal neurons of CA1 area and a role of inhibitory CB1-expressing synapses in the development of corticosterone-induced effects.	Corticosterone	211-225	cannabinoid receptor 1	Rattus norvegicus	165-168
28252602-6	2017	The data obtained suggest that both rapid and slow effects of corticosterone are associated with the activity of CB1-expressing inhibitory synapses of the hippocampus.	Corticosterone	62-76	cannabinoid receptor 1	Rattus norvegicus	113-116
27725213-7	2016	As expected, predator stress produced a stress response as detected by elevated corticosterone (CORT) levels immediately after stress.	Corticosterone	80-94	cortistatin	Rattus norvegicus	96-100
27992553-11	2016	Finally, we found that the circadian rhythm in adrenal corticosterone in Opn4::TeNT mice, as monitored by in vivo subcutaneous microdialysis, was desynchronized from environmental LD cycles.	Corticosterone	55-69	opsin 4 (melanopsin)	Mus musculus	73-77
27485250-3	2016	Repetitive corticosterone injection developed premature mammary gland involution only in B6.IL-10-/- mice; moreover, it induced alopecia in nursing pups.	Corticosterone	11-25	interleukin 10	Mus musculus	92-97
27485250-4	2016	Corticosterone injection induced several typical changes such as mammary gland epithelial cell apoptosis, macrophage infiltration, fat deposition in adipocyte, STAT3 phosphorylation, and upregulation of tyrosine hydroxylase gene in adrenal gland.	Corticosterone	0-14	signal transducer and activator of transcription 3	Mus musculus	160-165
27485250-6	2016	Our finding demonstrates that IL-10 is important for stress modulation, and B6.Il-10-/- with corticosterone has several advantage such as simple to establish, well-defined onset of mammary gland involution, high incidence, and inducing pup alopecia.	Corticosterone	93-107	interleukin 10	Mus musculus	79-84
27744052-10	2016	Resting levels of gluco- and mineralocorticoid receptor mRNA were smaller, while corticosterone-deactivating enzyme (11beta-HSD2) mRNA level were higher in the hippocampus of 10-day-old rats compared to adults.	Corticosterone	81-95	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	117-128
27744052-1	2016	AIMS: In vasopressin-deficient rat pups stressor-induced adrenocorticotropin (ACTH) and corticosterone elevations markedly dissociate.	Corticosterone	88-102	arginine vasopressin	Rattus norvegicus	9-20
26660117-0	2016	Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway.	Corticosterone	79-93	thymoma viral proto-oncogene 1	Mus musculus	103-106
26660117-0	2016	Creatine, Similar to Ketamine, Counteracts Depressive-Like Behavior Induced by Corticosterone via PI3K/Akt/mTOR Pathway.	Corticosterone	79-93	mechanistic target of rapamycin kinase	Mus musculus	107-111
26660117-12	2016	The immunocontents of p-mTOR, p-p70S6 kinase (p70S6K), and postsynaptic density-95 protein (PSD95) were increased by creatine and ketamine in corticosterone or vehicle-treated mice.	Corticosterone	142-156	mechanistic target of rapamycin kinase	Mus musculus	24-28
26660117-12	2016	The immunocontents of p-mTOR, p-p70S6 kinase (p70S6K), and postsynaptic density-95 protein (PSD95) were increased by creatine and ketamine in corticosterone or vehicle-treated mice.	Corticosterone	142-156	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	30-44
26660117-12	2016	The immunocontents of p-mTOR, p-p70S6 kinase (p70S6K), and postsynaptic density-95 protein (PSD95) were increased by creatine and ketamine in corticosterone or vehicle-treated mice.	Corticosterone	142-156	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	46-52
26660117-12	2016	The immunocontents of p-mTOR, p-p70S6 kinase (p70S6K), and postsynaptic density-95 protein (PSD95) were increased by creatine and ketamine in corticosterone or vehicle-treated mice.	Corticosterone	142-156	discs large MAGUK scaffold protein 4	Mus musculus	92-97
26660117-13	2016	Moreover, corticosterone-treated mice presented a decreased hippocampal brain-derived neurotrophic factor (BDNF) level, an effect abolished by creatine or ketamine.	Corticosterone	10-24	brain derived neurotrophic factor	Mus musculus	72-105
26660117-13	2016	Moreover, corticosterone-treated mice presented a decreased hippocampal brain-derived neurotrophic factor (BDNF) level, an effect abolished by creatine or ketamine.	Corticosterone	10-24	brain derived neurotrophic factor	Mus musculus	107-111
26660117-14	2016	Altogether, the results indicate that creatine shares with ketamine the ability to acutely reverse the corticosterone-induced depressive-like behavior by a mechanism dependent on PI3K/AKT/mTOR pathway, and modulation of the synaptic protein PSD95 as well as BDNF in the hippocampus, indicating the relevance of targeting these proteins for the management of depressive disorders.	Corticosterone	103-117	thymoma viral proto-oncogene 1	Mus musculus	184-187
26660117-14	2016	Altogether, the results indicate that creatine shares with ketamine the ability to acutely reverse the corticosterone-induced depressive-like behavior by a mechanism dependent on PI3K/AKT/mTOR pathway, and modulation of the synaptic protein PSD95 as well as BDNF in the hippocampus, indicating the relevance of targeting these proteins for the management of depressive disorders.	Corticosterone	103-117	mechanistic target of rapamycin kinase	Mus musculus	188-192
26660117-14	2016	Altogether, the results indicate that creatine shares with ketamine the ability to acutely reverse the corticosterone-induced depressive-like behavior by a mechanism dependent on PI3K/AKT/mTOR pathway, and modulation of the synaptic protein PSD95 as well as BDNF in the hippocampus, indicating the relevance of targeting these proteins for the management of depressive disorders.	Corticosterone	103-117	discs large MAGUK scaffold protein 4	Mus musculus	241-246
26660117-14	2016	Altogether, the results indicate that creatine shares with ketamine the ability to acutely reverse the corticosterone-induced depressive-like behavior by a mechanism dependent on PI3K/AKT/mTOR pathway, and modulation of the synaptic protein PSD95 as well as BDNF in the hippocampus, indicating the relevance of targeting these proteins for the management of depressive disorders.	Corticosterone	103-117	brain derived neurotrophic factor	Mus musculus	258-262
27432545-4	2016	Corticosterone (CORT, a murine GC) treatment did not affect the proliferation of eNSPCs.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
27870896-5	2016	CORT-treated rats exhibited depressive-like behavior with significant elevated levels of MAO activities, serotonin turnover, oxidative stress, neuroinflammation and apoptosis in the hippocampus with significant losses of synaptic proteins when compared to the control.	Corticosterone	0-4	monoamine oxidase A	Rattus norvegicus	89-92
27870896-6	2016	The expression and activity of cytokine-responsive indoleamine 2,3-dioxygenase (IDO-1), a catabolic enzyme of serotonin and tryptophan, was significantly increased in the CORT-treated group with lowered levels of serotonin.	Corticosterone	171-175	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	80-85
27870896-9	2016	Our results suggest that M30 is neuroprotective against CORT-induced depression targeting elevated MAO activities that cause oxidative stress and neuroinflammation, resulting in IDO-1 activation, serotonin deficiency and neurodegeneration.	Corticosterone	56-60	monoamine oxidase A	Rattus norvegicus	99-102
27870896-9	2016	Our results suggest that M30 is neuroprotective against CORT-induced depression targeting elevated MAO activities that cause oxidative stress and neuroinflammation, resulting in IDO-1 activation, serotonin deficiency and neurodegeneration.	Corticosterone	56-60	indoleamine 2,3-dioxygenase 1	Rattus norvegicus	178-183
27807170-3	2016	Here, we demonstrate novel synergistic actions of corticosterone and corticotropin-releasing hormone (CRH) on synaptic physiology and dendritic spine structure that mediate the profound effects of acute concurrent stresses on memory.	Corticosterone	50-64	corticotropin releasing hormone	Mus musculus	102-105
27807170-6	2016	Mechanistically, corticosterone and CRH, via their cognate receptors, acted synergistically on the spine-actin regulator RhoA, promoting its deactivation and degradation, respectively, and destabilizing spines.	Corticosterone	17-31	ras homolog family member A	Mus musculus	121-125
27807170-13	2016	Mechanistically, corticosterone and CRH synergized at the spine-actin regulator RhoA, promoting its deactivation and degradation, respectively, and destabilizing spines.	Corticosterone	17-31	ras homolog family member A	Mus musculus	80-84
27142032-2	2016	The main goal of our study was to check if the repeated administration of corticosterone (CORT) is able to evoke the depressive-like behaviour and detrusor overactivity (DO) symptoms in rats.	Corticosterone	74-88	cortistatin	Rattus norvegicus	90-94
27263429-5	2016	While corticosterone levels were not different among groups, CBG levels were lower in PAE offspring from P1 to P8, suggesting a lower corticosterone reservoir that may underlie susceptibility to inflammation.	Corticosterone	134-148	serpin family A member 6	Rattus norvegicus	61-64
27448526-10	2016	The greater stressor-induced GR translocation in pre-pubertal adolescents parallels their greater release of corticosterone in response to stressors, which may contribute to the enhanced sensitivity of adolescent rats to the effects of chronic stress exposures compared with adults.	Corticosterone	109-123	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	29-31
27113500-9	2016	The SCN-Bmal1-KD mice also showed greater weight gain, an abnormal circadian pattern of corticosterone, and an attenuated increase of corticosterone in response to stress.	Corticosterone	88-102	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	8-13
27113500-9	2016	The SCN-Bmal1-KD mice also showed greater weight gain, an abnormal circadian pattern of corticosterone, and an attenuated increase of corticosterone in response to stress.	Corticosterone	134-148	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	8-13
27841456-1	2016	Corticosterone (CORT) is a stress-related steroid hormone found in vertebrates, and is known to interact with behavior.	Corticosterone	0-14	cortistatin	Microtus ochrogaster	16-20
27395784-11	2016	In contrast, rats receiving CRHr1 inhibitor showed reduced severity and duration of seizures, increased GABA, decreased glutamate and corticosterone and also orexin mRNA compared to the inhibitor free rats.	Corticosterone	134-148	corticotropin releasing hormone receptor 1	Rattus norvegicus	28-33
30193444-3	2016	CB1 receptor antagonists promote an increase in ACTH and corticosterone concentrations in the blood of intact animals, the knockout of the gene encoding the CB1 receptor exhibits the same effect.	Corticosterone	57-71	cannabinoid receptor 1 (brain)	Mus musculus	0-3
30193444-4	2016	Antagonists of CB1 receptors enhance the stressor elevation of ACTH and corticosterone levels in the blood of experimental animals.	Corticosterone	72-86	cannabinoid receptor 1 (brain)	Mus musculus	15-18
27153999-10	2016	In contrast, the mineralocorticoid receptor (MR) antagonist eplerenone (10muM) significantly decreased corticosterone- (0.81 fold compared to treatment with corticosterone alone; P&lt;0.01) and 11-DHC-driven (0.64 fold compared to treatment with 11-DHC alone; P&lt;0.01) VSMC calcification, suggesting this glucocorticoid effect is MR-driven and not GR-driven.	Corticosterone	103-117	nuclear receptor subfamily 3, group C, member 2	Mus musculus	17-43
30193444-5	2016	It was found an increase in stress-induced elevation of corticosterone and ACTH levels in the blood of mice with a knockout of the gene encoding the CB1 receptor.	Corticosterone	56-70	cannabinoid receptor 1 (brain)	Mus musculus	149-152
27153999-10	2016	In contrast, the mineralocorticoid receptor (MR) antagonist eplerenone (10muM) significantly decreased corticosterone- (0.81 fold compared to treatment with corticosterone alone; P&lt;0.01) and 11-DHC-driven (0.64 fold compared to treatment with 11-DHC alone; P&lt;0.01) VSMC calcification, suggesting this glucocorticoid effect is MR-driven and not GR-driven.	Corticosterone	103-117	nuclear receptor subfamily 3, group C, member 2	Mus musculus	45-47
27153999-10	2016	In contrast, the mineralocorticoid receptor (MR) antagonist eplerenone (10muM) significantly decreased corticosterone- (0.81 fold compared to treatment with corticosterone alone; P&lt;0.01) and 11-DHC-driven (0.64 fold compared to treatment with 11-DHC alone; P&lt;0.01) VSMC calcification, suggesting this glucocorticoid effect is MR-driven and not GR-driven.	Corticosterone	157-171	nuclear receptor subfamily 3, group C, member 2	Mus musculus	17-43
27153999-10	2016	In contrast, the mineralocorticoid receptor (MR) antagonist eplerenone (10muM) significantly decreased corticosterone- (0.81 fold compared to treatment with corticosterone alone; P&lt;0.01) and 11-DHC-driven (0.64 fold compared to treatment with 11-DHC alone; P&lt;0.01) VSMC calcification, suggesting this glucocorticoid effect is MR-driven and not GR-driven.	Corticosterone	157-171	nuclear receptor subfamily 3, group C, member 2	Mus musculus	45-47
27153999-12	2016	However, DAPI staining of pyknotic nuclei and flow cytometry analysis of surface Annexin V expression showed that corticosterone induced apoptosis in VSMCs.	Corticosterone	114-128	annexin A5	Mus musculus	81-90
27387555-0	2016	Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway.	Corticosterone	74-88	brain derived neurotrophic factor	Mus musculus	110-114
27708250-8	2016	In a murine corticotroph tumor in vivo model of Cushing"s disease, MEK-162 treatment inhibited tumor growth and reduced tumor-derived circulating plasma ACTH, and corticosterone levels.	Corticosterone	163-177	midkine	Mus musculus	67-70
27559012-5	2016	Plasma corticosterone (CORT) and arginine vasotocin (AVT) concentrations were significantly increased in the immobilized and hypertonic saline groups (p&lt;0.01) compared to controls.	Corticosterone	7-21	CORT	Gallus gallus	23-27
27741227-8	2016	Plasma corticosterone levels significantly increased 6 weeks after TAC, and chronic treatment of mice with corticosterone for 3 weeks elicited depression-like behaviors concomitant with reduced astrocytic sigma1R expression in hippocampus.	Corticosterone	107-121	sigma non-opioid intracellular receptor 1	Mus musculus	205-212
27741227-10	2016	We conclude that elevated corticosterone levels trigger hippocampal sigma1R downregulation and that sigma1R stimulation with SA4503 is an attractive therapy to improve not only cardiac dysfunction but depression-like behaviors associated with heart failure.	Corticosterone	26-40	sigma non-opioid intracellular receptor 1	Mus musculus	68-75
27242185-7	2016	Serum corticosterone (active) levels, which are regulated by 11beta-HSD1 were reduced when mice received H8.	Corticosterone	6-20	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	61-72
27701413-6	2016	We hypothesised that this difference in behaviour may be due to an interaction between neuropsin and elevated plasma corticosterone.	Corticosterone	117-131	opsin 5	Mus musculus	87-96
27701413-9	2016	We found that inactivation of neuropsin limits the extent of these anatomical changes in both the chronic stress and the corticosterone injection exposed cohorts.	Corticosterone	121-135	opsin 5	Mus musculus	30-39
27701413-11	2016	Additionally, we found that inactivation of neuropsin limited glutamate dysregulation, associated with increased generation of reactive oxygen species, resulting from prolonged elevated plasma corticosterone.	Corticosterone	193-207	opsin 5	Mus musculus	44-53
27701413-12	2016	In this study, we demonstrate that neuropsin inactivation protects against the impairment of hippocampal functions and the depressive-like behaviour induced by chronic stress or high levels of corticosterone.	Corticosterone	193-207	opsin 5	Mus musculus	35-44
27490185-6	2016	Des-acyl ghrelin influences plasma corticosterone under both nonstressed and stressed conditions, although c-fos activation in the paraventricular nucleus of the hypothalamus is not different.	Corticosterone	35-49	appetite-regulating hormone	Capra hircus	9-16
27501468-4	2016	Our previous studies demonstrated that NET mRNA and protein levels in rats are regulated by chronic stress and by administration of corticosterone, which is mediated through glucocorticoid receptors.	Corticosterone	132-146	solute carrier family 6 member 2	Rattus norvegicus	39-42
27501468-14	2016	Also, exposure of cells to corticosterone significantly reduced miR-29b levels through a GR-independent way.	Corticosterone	27-41	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	89-91
27522966-0	2016	HPOB, an HDAC6 inhibitor, attenuates corticosterone-induced injury in rat adrenal pheochromocytoma PC12 cells by inhibiting mitochondrial GR translocation and the intrinsic apoptosis pathway.	Corticosterone	37-51	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	138-140
25866012-2	2016	In rodents, global cerebral ischemia leads to selective CA1 neuronal damage, spatial memory impairments, lasting changes in corticosterone (CORT) secretion, and increased neurogenesis.	Corticosterone	124-138	cortistatin	Rattus norvegicus	140-144
27387555-0	2016	Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway.	Corticosterone	74-88	cAMP responsive element binding protein 1	Mus musculus	120-124
27567758-1	2016	BACKGROUND: Our previous work has shown that exposure to the stress hormone corticosterone (40 mg/kg CORT) for two weeks induces dendritic atrophy of pyramidal neurons in the hippocampal CA3 region and behavioral deficits.	Corticosterone	76-90	cortistatin	Rattus norvegicus	101-105
27393316-1	2016	Adult neurogenesis within the dentate gyrus (DG) of the hippocampus can be increased by voluntary exercise but is suppressed under stress, such as with corticosterone (CORT).	Corticosterone	152-166	cortistatin	Rattus norvegicus	168-172
27693335-7	2016	RESULTS AND DISCUSSION: TRPV1 modulators reversed (p&lt;0.05) the increase in immobility period, anxiety, spleen weight, BUN and LDH levels, and MDA levels along with decrease in grip strength, locomotor activity, plasma corticosterone, adrenal gland weight, catalase, and GSH.	Corticosterone	221-235	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
27431412-5	2016	The 11beta-HSD1 isoform is predominantly a reductase, which catalyzes nicotinamide adenine dinucleotide phosphate hydrogen-dependent conversion of cortisone/11-DHC to cortisol/corticosterone, and is widely expressed and present at the highest levels in the liver, lungs, adipose tissues, ovaries, and central nervous system.	Corticosterone	176-190	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	4-15
27431412-6	2016	The 11beta-HSD2 isoform, which catalyzes nicotinamide adenine dinucleotide+-dependent inactivation of cortisol/corticosterone to cortisone/11-DHC, is highly expressed in distal nephrons, the colon, sweat glands, and the placenta.	Corticosterone	111-125	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	4-15
27387555-0	2016	Schisandra chinensis produces the antidepressant-like effects in repeated corticosterone-induced mice via the BDNF/TrkB/CREB signaling pathway.	Corticosterone	74-88	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	115-119
27376948-6	2016	METHODS: PACAP was microinfused into the CeA of rats, and its effects in the elevated plus maze (EPM), the defensive withdrawal tests, and plasma corticosterone levels were evaluated.	Corticosterone	146-160	adenylate cyclase activating polypeptide 1	Rattus norvegicus	9-14
27380730-9	2016	In normal rats, mean AWR score, EMG activity, and corticosterone expression were significantly increased after nesfatin-1 injection into the amygdala.	Corticosterone	50-64	nucleobindin 2	Rattus norvegicus	111-121
27376201-8	2016	The highest OCT3 inhibition was observed for corticosterone, but clinically used corticosteroids, showed also promising inhibitory effects.	Corticosterone	45-59	solute carrier family 22 member 3	Homo sapiens	12-16
27243477-9	2016	We speculate that persistent NPFFR2 activation, in particular in the hypothalamus, up-regulates the HPA axis and results in long-lasting increases in circulating corticosterone (CORT), consequently damaging hippocampal function.	Corticosterone	162-176	neuropeptide FF receptor 2	Mus musculus	29-35
27243477-9	2016	We speculate that persistent NPFFR2 activation, in particular in the hypothalamus, up-regulates the HPA axis and results in long-lasting increases in circulating corticosterone (CORT), consequently damaging hippocampal function.	Corticosterone	178-182	neuropeptide FF receptor 2	Mus musculus	29-35
27249795-0	2016	Corticosterone regulates fear memory via Rac1 activity in the hippocampus.	Corticosterone	0-14	Rac family small GTPase 1	Homo sapiens	41-45
27249795-4	2016	Firstly, we detected the time course changes of Rac1-GTP after foot shocks (a strong stressor) and exogenous corticosterone (CORT) treatment.	Corticosterone	109-123	cortistatin	Homo sapiens	125-129
27292791-1	2016	We sought to clarify functional relationships between baseline and acute stress-induced changes in plasma levels of the stress hormone corticosterone (CORT) and the reproductive hormone testosterone (T), and those of two main metabolites, uric acid (UA) and glucose (GLU).	Corticosterone	135-149	cortistatin	Homo sapiens	151-155
27153522-10	2016	Through the use of the Cbg ko mice, which only differs genetically from WT mice by the absence of CBG, we demonstrated that CBG is crucial in modulating the effects of stress on plasma corticosterone levels and consequently on behavior.	Corticosterone	185-199	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	124-127
27595136-6	2016	The blockade of corticosterone action with the glucocorticoid receptor antagonist mifepristone prevented the NLRP3 and HMGB1 increases in unchallenged animals, normalized the proinflammatory response to LPS, and prevented the memory impairment.	Corticosterone	16-30	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	47-70
27595136-6	2016	The blockade of corticosterone action with the glucocorticoid receptor antagonist mifepristone prevented the NLRP3 and HMGB1 increases in unchallenged animals, normalized the proinflammatory response to LPS, and prevented the memory impairment.	Corticosterone	16-30	NLR family, pyrin domain containing 3	Rattus norvegicus	109-114
27595136-6	2016	The blockade of corticosterone action with the glucocorticoid receptor antagonist mifepristone prevented the NLRP3 and HMGB1 increases in unchallenged animals, normalized the proinflammatory response to LPS, and prevented the memory impairment.	Corticosterone	16-30	high mobility group box 1	Rattus norvegicus	119-124
27535620-5	2016	Conversely, ABCC1 exports corticosterone but not cortisol.	Corticosterone	26-40	ATP binding cassette subfamily C member 1	Homo sapiens	12-17
27535620-6	2016	We show that ABCC1, but not ABCB1, is expressed in human adipose and that ABCC1 inhibition increases intracellular corticosterone, but not cortisol, and induces glucocorticoid-responsive gene transcription in human adipocytes.	Corticosterone	115-129	ATP binding cassette subfamily C member 1	Homo sapiens	13-18
27535620-6	2016	We show that ABCC1, but not ABCB1, is expressed in human adipose and that ABCC1 inhibition increases intracellular corticosterone, but not cortisol, and induces glucocorticoid-responsive gene transcription in human adipocytes.	Corticosterone	115-129	ATP binding cassette subfamily C member 1	Homo sapiens	74-79
27535620-7	2016	Both C57Bl/6 mice treated with the ABCC1 inhibitor probenecid and FVB mice with deletion of Abcc1 accumulated more corticosterone than cortisol in adipose after adrenalectomy and corticosteroid infusion.	Corticosterone	115-129	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	92-97
27535620-10	2016	To test the hypothesis that corticosterone effectively suppresses adrenocorticotropic hormone (ACTH) without the metabolic adverse effects of cortisol, we infused cortisol or corticosterone in patients with Addison"s disease.	Corticosterone	28-42	proopiomelanocortin	Homo sapiens	66-93
27535620-10	2016	To test the hypothesis that corticosterone effectively suppresses adrenocorticotropic hormone (ACTH) without the metabolic adverse effects of cortisol, we infused cortisol or corticosterone in patients with Addison"s disease.	Corticosterone	28-42	proopiomelanocortin	Homo sapiens	95-99
27535620-12	2016	These data indicate that corticosterone may be a metabolically favorable alternative to cortisol for glucocorticoid replacement therapy when ACTH suppression is desirable, as in congenital adrenal hyperplasia, and justify development of a pharmaceutical preparation.	Corticosterone	25-39	proopiomelanocortin	Homo sapiens	141-145
27510168-2	2016	We have previously shown that an anti-A2AR therapy reverts age-like memory deficits, by reestablishment of the hypothalamic-pituitary-adrenal (HPA) axis feedback and corticosterone circadian levels.	Corticosterone	166-180	adenosine A2a receptor	Homo sapiens	38-42
27510168-4	2016	We now show that inducing A2AR overexpression in an aging-like profile is sufficient to trigger HPA-axis dysfunction, namely loss of plasmatic corticosterone circadian oscillation, and promotes reduction of GR hippocampal levels.	Corticosterone	143-157	adenosine A2a receptor	Homo sapiens	26-30
27477270-6	2016	Furthermore, we show that miR-17-92 expression in the adult mouse hippocampus responds to chronic stress, and miR-17-92 rescues proliferation defects induced by corticosterone in hippocampal neural progenitors.	Corticosterone	161-175	Mir17 host gene (non-protein coding)	Mus musculus	110-119
27502757-3	2016	In this study, we used the chronic corticosterone (CORT)-induced mouse model of anxiety/depression to assess antidepressant-like effects of baicalin and illuminate possible molecular mechanisms by which baicalin affects GR-mediated hippocampal neurogenesis.	Corticosterone	35-49	nuclear receptor subfamily 3, group C, member 1	Mus musculus	220-222
27254001-5	2016	We reveal that pretreatment of corticotrophs with 100 nM corticosterone (CORT; 90 and 150 min) reduces spontaneous activity and prevents a transition from spiking to bursting after CRH/arginine vasopressin stimulation.	Corticosterone	57-71	cortistatin	Mus musculus	73-77
27254001-5	2016	We reveal that pretreatment of corticotrophs with 100 nM corticosterone (CORT; 90 and 150 min) reduces spontaneous activity and prevents a transition from spiking to bursting after CRH/arginine vasopressin stimulation.	Corticosterone	57-71	corticotropin releasing hormone	Mus musculus	181-184
27082452-0	2016	Estradiol and corticosterone stimulate the proliferation of a GH cell line, MtT/S: Proliferation of growth hormone cells.	Corticosterone	14-28	gonadotropin releasing hormone receptor	Rattus norvegicus	62-64
27082452-0	2016	Estradiol and corticosterone stimulate the proliferation of a GH cell line, MtT/S: Proliferation of growth hormone cells.	Corticosterone	14-28	gonadotropin releasing hormone receptor	Rattus norvegicus	100-114
27082452-10	2016	The effects of corticosterone were inhibited by glucocorticoid receptor inhibitor, RU486, but not by the mineralocorticoid receptor antagonist, spironolactone.	Corticosterone	15-29	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	48-71
27102048-6	2016	RESULTS: Corticosterone (CORT) exposure increased abdominal fat mass and induced expression of lipid synthase acetyl-CoA carboxylase and ATP-citrate lyase with activation of GSK3beta phosphorylation in abdominal adipose tissue of C57BL/6J mice.	Corticosterone	9-23	ATP citrate lyase	Mus musculus	137-154
27102048-6	2016	RESULTS: Corticosterone (CORT) exposure increased abdominal fat mass and induced expression of lipid synthase acetyl-CoA carboxylase and ATP-citrate lyase with activation of GSK3beta phosphorylation in abdominal adipose tissue of C57BL/6J mice.	Corticosterone	9-23	glycogen synthase kinase 3 beta	Mus musculus	174-182
27102048-6	2016	RESULTS: Corticosterone (CORT) exposure increased abdominal fat mass and induced expression of lipid synthase acetyl-CoA carboxylase and ATP-citrate lyase with activation of GSK3beta phosphorylation in abdominal adipose tissue of C57BL/6J mice.	Corticosterone	25-29	ATP citrate lyase	Mus musculus	137-154
27102048-6	2016	RESULTS: Corticosterone (CORT) exposure increased abdominal fat mass and induced expression of lipid synthase acetyl-CoA carboxylase and ATP-citrate lyase with activation of GSK3beta phosphorylation in abdominal adipose tissue of C57BL/6J mice.	Corticosterone	25-29	glycogen synthase kinase 3 beta	Mus musculus	174-182
27418032-11	2016	Dynamic changes in the levels and function of CBG likely modulate the tissue availability of corticosterone during inflammation.	Corticosterone	93-107	serpin family A member 6	Rattus norvegicus	46-49
27412469-0	2016	Involvement of PI3K/Akt/FoxO3a and PKA/CREB Signaling Pathways in the Protective Effect of Fluoxetine Against Corticosterone-Induced Cytotoxicity in PC12 Cells.	Corticosterone	110-124	cAMP responsive element binding protein 1	Rattus norvegicus	39-43
27412469-4	2016	Here, we used PC12 cells exposed to corticosterone (CORT) to study the neuroprotective effects of fluoxetine and the involvement of the PI3K/Akt/FoxO3a and PKA/CREB signaling pathways.	Corticosterone	36-50	cortistatin	Rattus norvegicus	52-56
27279479-7	2016	In conclusion, the present study demonstrated that Dan-zhi-xiao-yao-san exerted anxiolytic and neuroprotective effects in a rat model of chronic stress via attenuation of stress-induced upregulation of alpha-synuclein and corticosterone, and downregulation of PP2A in the hippocampus.	Corticosterone	222-236	synuclein alpha	Rattus norvegicus	202-217
27208833-0	2016	Disruption of the HPA-axis through corticosterone-release pellets induces robust depressive-like behavior and reduced BDNF levels in mice.	Corticosterone	35-49	brain derived neurotrophic factor	Mus musculus	118-122
27208833-4	2016	We show that three weeks of corticosterone pellet exposure robustly induces depressive-like but not anxiety-like behavior in mice, accompanied by a significant decrease in hippocampal brain-derived neurotrophic factor levels, at five weeks after the start of treatment.	Corticosterone	28-42	brain derived neurotrophic factor	Mus musculus	184-217
27465581-7	2016	RESULTS: PARP overactivation in ANP rats is associated with reduced serum corticosterone level and marked cellular alterations in adrenocortical tissue.	Corticosterone	74-88	poly (ADP-ribose) polymerase 1	Rattus norvegicus	9-13
27145012-1	2016	Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respectively.	Corticosterone	204-218	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	87-129
27145012-1	2016	Endogenous glucocorticoid action within cells is enhanced by prereceptor metabolism by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which converts intrinsically inert cortisone and 11-dehydrocorticosterone into active cortisol and corticosterone, respectively.	Corticosterone	204-218	RNA, U1 small nuclear 1	Homo sapiens	131-142
27175972-2	2016	Indeed, although female CORT-knockout (CORT-KO) mice exhibit enhanced GH expression/secretion, Proopiomelanocortin expression, and circulating ACTH/corticosterone/ghrelin levels, male CORT-KO mice only display increased plasma GH/corticosterone levels.	Corticosterone	148-162	cortistatin	Mus musculus	24-28
27175972-2	2016	Indeed, although female CORT-knockout (CORT-KO) mice exhibit enhanced GH expression/secretion, Proopiomelanocortin expression, and circulating ACTH/corticosterone/ghrelin levels, male CORT-KO mice only display increased plasma GH/corticosterone levels.	Corticosterone	148-162	cortistatin	Mus musculus	39-43
27175972-2	2016	Indeed, although female CORT-knockout (CORT-KO) mice exhibit enhanced GH expression/secretion, Proopiomelanocortin expression, and circulating ACTH/corticosterone/ghrelin levels, male CORT-KO mice only display increased plasma GH/corticosterone levels.	Corticosterone	148-162	cortistatin	Mus musculus	39-43
27175972-9	2016	Fasting increased corticosterone levels in control and, most prominently, in CORT-KO mice, which might be associated with a desensitization to SST signaling and to an augmentation in CRH and ghrelin-signaling regulating corticotrope function.	Corticosterone	18-32	cortistatin	Mus musculus	77-81
27175972-9	2016	Fasting increased corticosterone levels in control and, most prominently, in CORT-KO mice, which might be associated with a desensitization to SST signaling and to an augmentation in CRH and ghrelin-signaling regulating corticotrope function.	Corticosterone	18-32	corticotropin releasing hormone	Mus musculus	183-186
27317610-3	2016	These experiments were designed to test the hypothesis that a single diffuse TBI results in chronic dysfunction of corticosterone (CORT), a glucocorticoid released in response to stress and testosterone.	Corticosterone	115-129	cortistatin	Rattus norvegicus	131-135
26766634-3	2016	Peptides which specifically block the interaction between N-Ethylmaleimide-Sensitive Factor (NSF) and the AMPAR-subunit GluA2 prevented the increase in synaptic transmission and surface expression of AMPARs known to occur after corticosterone application to hippocampal neurons.	Corticosterone	228-242	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	58-91
26766634-3	2016	Peptides which specifically block the interaction between N-Ethylmaleimide-Sensitive Factor (NSF) and the AMPAR-subunit GluA2 prevented the increase in synaptic transmission and surface expression of AMPARs known to occur after corticosterone application to hippocampal neurons.	Corticosterone	228-242	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	93-96
26766634-3	2016	Peptides which specifically block the interaction between N-Ethylmaleimide-Sensitive Factor (NSF) and the AMPAR-subunit GluA2 prevented the increase in synaptic transmission and surface expression of AMPARs known to occur after corticosterone application to hippocampal neurons.	Corticosterone	228-242	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	120-125
26766634-3	2016	Peptides which specifically block the interaction between N-Ethylmaleimide-Sensitive Factor (NSF) and the AMPAR-subunit GluA2 prevented the increase in synaptic transmission and surface expression of AMPARs known to occur after corticosterone application to hippocampal neurons.	Corticosterone	228-242	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	200-206
26766634-4	2016	Combining a live imaging Fluorescence Recovery After Photobleaching (FRAP) approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that this NSF/GluA2 interaction was also essential for the increase of the mobile fraction and reduction of the diffusion of AMPARs after treating hippocampal neurons with corticosterone.	Corticosterone	316-330	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	154-157
26766634-4	2016	Combining a live imaging Fluorescence Recovery After Photobleaching (FRAP) approach with the use of the pH-sensitive GFP-AMPAR tagging revealed that this NSF/GluA2 interaction was also essential for the increase of the mobile fraction and reduction of the diffusion of AMPARs after treating hippocampal neurons with corticosterone.	Corticosterone	316-330	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	158-163
26766634-5	2016	We conclude that the interaction between NSF and GluA2 contributes to the effects of corticosterone on AMPAR function.	Corticosterone	85-99	N-ethylmaleimide sensitive factor, vesicle fusing ATPase	Homo sapiens	41-44
26766634-5	2016	We conclude that the interaction between NSF and GluA2 contributes to the effects of corticosterone on AMPAR function.	Corticosterone	85-99	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	49-54
27099398-11	2016	Overall, KCNJ5(T158A)increases CYP11B2 expression and production of aldosterone, corticosterone and hybrid steroids by upregulating both acute and chronic regulatory events in aldosterone production, and verapamil blocks KCNJ5(T158A)-mediated pathways leading to aldosterone production.	Corticosterone	81-95	potassium inwardly rectifying channel subfamily J member 5	Homo sapiens	9-14
27189478-5	2016	In contrast, in 3-day cultures, corticosterone (1 muM) increased caspase-3 activity and the mRNA expression of the pro-apoptotic Bax.	Corticosterone	32-46	caspase 3	Rattus norvegicus	65-74
27189478-5	2016	In contrast, in 3-day cultures, corticosterone (1 muM) increased caspase-3 activity and the mRNA expression of the pro-apoptotic Bax.	Corticosterone	32-46	BCL2 associated X, apoptosis regulator	Rattus norvegicus	129-132
27189478-6	2016	Moreover, corticosterone"s effect on caspase-3 activity was stronger in hippocampal cultures from prenatally stressed compared to control rats.	Corticosterone	10-24	caspase 3	Rattus norvegicus	37-46
27189478-7	2016	Additionally, 24 h of exposure to corticosterone and glutamate, when applied separately and together, increased Bdnf, Ngf, and Tnf-alpha expression.	Corticosterone	34-48	brain-derived neurotrophic factor	Rattus norvegicus	112-116
27189478-7	2016	Additionally, 24 h of exposure to corticosterone and glutamate, when applied separately and together, increased Bdnf, Ngf, and Tnf-alpha expression.	Corticosterone	34-48	nerve growth factor	Rattus norvegicus	118-121
27189478-7	2016	Additionally, 24 h of exposure to corticosterone and glutamate, when applied separately and together, increased Bdnf, Ngf, and Tnf-alpha expression.	Corticosterone	34-48	tumor necrosis factor	Rattus norvegicus	127-136
27189478-11	2016	Increased synthesis of the pro-inflammatory cytokine TNF-alpha may be connected with the adverse effects of corticosterone on brain cell viability.	Corticosterone	108-122	tumor necrosis factor	Rattus norvegicus	53-62
27099398-11	2016	Overall, KCNJ5(T158A)increases CYP11B2 expression and production of aldosterone, corticosterone and hybrid steroids by upregulating both acute and chronic regulatory events in aldosterone production, and verapamil blocks KCNJ5(T158A)-mediated pathways leading to aldosterone production.	Corticosterone	81-95	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	31-38
26961889-0	2016	Apelin-13 Protects PC12 Cells from Corticosterone-Induced Apoptosis Through PI3K and ERKs Activation.	Corticosterone	35-49	apelin	Rattus norvegicus	0-6
25966970-11	2016	Agmatine also abolished the corticosterone-induced changes in the morphology of astrocytes and microglia in CA1 region of hippocampus.	Corticosterone	28-42	carbonic anhydrase 1	Mus musculus	108-111
26961889-6	2016	However, the effect of apelin on corticosterone-induced neuronal damage remains to be elucidated.	Corticosterone	33-47	apelin	Rattus norvegicus	23-29
26961889-7	2016	In the present study, we explored the potential protective activity of apelin-13 in PC12 cells treated with corticosterone and its underling mechanisms.	Corticosterone	108-122	apelin	Rattus norvegicus	71-77
26961889-9	2016	Results showed that corticosterone induced cells viability loss, cell apoptosis, down-regulation of p-Akt and p-ERKs and up-regulation of cleaved caspase-3.	Corticosterone	20-34	AKT serine/threonine kinase 1	Rattus norvegicus	102-105
26961889-9	2016	Results showed that corticosterone induced cells viability loss, cell apoptosis, down-regulation of p-Akt and p-ERKs and up-regulation of cleaved caspase-3.	Corticosterone	20-34	caspase 3	Rattus norvegicus	146-155
26961889-10	2016	The effects induced by corticosterone were attenuated by apelin-13 pretreatment.	Corticosterone	23-37	apelin	Rattus norvegicus	57-63
26961889-12	2016	The data suggest that apelin-13 protects PC12 cells from corticosterone-induced apoptosis through activating PI3K/Akt and ERKs signaling pathways.	Corticosterone	57-71	apelin	Rattus norvegicus	22-28
26961889-12	2016	The data suggest that apelin-13 protects PC12 cells from corticosterone-induced apoptosis through activating PI3K/Akt and ERKs signaling pathways.	Corticosterone	57-71	AKT serine/threonine kinase 1	Rattus norvegicus	114-117
26996390-14	2016	These results suggested that acrolein decreased the releasing ability of corticosterone via an inhibition on the response of ZFR cells to ACTH and the reduction of protein expressions of StAR and MC2R as well as the activity of P450scc in rat ZFR cells.	Corticosterone	73-87	melanocortin 2 receptor	Rattus norvegicus	196-200
27442776-7	2016	vGluT3 KO mice reacted to an immune stressor with enhanced adrenocorticotropin (ACTH) and corticosterone secretion compared to WT.	Corticosterone	90-104	solute carrier family 17 (sodium-dependent inorganic phosphate cotransporter), member 8	Mus musculus	0-6
27484105-10	2016	Moreover, CRH deficiency leads to different responses to stress in gene expression of TH, NE concentrations, CRH receptor mRNA, and plasma corticosterone levels.	Corticosterone	139-153	corticotropin releasing hormone	Mus musculus	10-13
26996390-14	2016	These results suggested that acrolein decreased the releasing ability of corticosterone via an inhibition on the response of ZFR cells to ACTH and the reduction of protein expressions of StAR and MC2R as well as the activity of P450scc in rat ZFR cells.	Corticosterone	73-87	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	228-235
28955903-6	2016	Corticosterone levels were elevated in malnourished mice and this correlated in time with peripheral T cell up-regulation of CD127 and the diminishment of the peripheral T cell pool.	Corticosterone	0-14	interleukin 7 receptor	Mus musculus	125-130
27300263-3	2016	Male breeders were administered water supplemented with corticosterone (CORT) for 4 weeks before mating with untreated female mice.	Corticosterone	56-70	cortistatin	Mus musculus	72-76
27070821-7	2016	Similarly in mouse keratinocytes in vitro, corticosterone dose dependently suppressed 2,4,6-trinitrobenzenesulfonic acid-induced IL-1alpha and IL-1beta expression.	Corticosterone	43-57	interleukin 1 alpha	Mus musculus	129-138
27070821-7	2016	Similarly in mouse keratinocytes in vitro, corticosterone dose dependently suppressed 2,4,6-trinitrobenzenesulfonic acid-induced IL-1alpha and IL-1beta expression.	Corticosterone	43-57	interleukin 1 beta	Mus musculus	143-151
27070821-10	2016	Taken together, these data suggest that corticosterone activation by 11beta-HSD1 in keratinocytes suppresses hapten-induced irritant dermatitis through suppression of expression of cytokines, such as IL-1alpha and IL-1beta, in keratinocytes.	Corticosterone	40-54	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	69-80
27070821-10	2016	Taken together, these data suggest that corticosterone activation by 11beta-HSD1 in keratinocytes suppresses hapten-induced irritant dermatitis through suppression of expression of cytokines, such as IL-1alpha and IL-1beta, in keratinocytes.	Corticosterone	40-54	interleukin 1 alpha	Mus musculus	200-209
27070821-10	2016	Taken together, these data suggest that corticosterone activation by 11beta-HSD1 in keratinocytes suppresses hapten-induced irritant dermatitis through suppression of expression of cytokines, such as IL-1alpha and IL-1beta, in keratinocytes.	Corticosterone	40-54	interleukin 1 beta	Mus musculus	214-222
26686316-3	2016	Supporting this hypothesis, several studies have found that human disturbance is associated with increased circulating corticosterone (CORT) levels.	Corticosterone	119-133	cortistatin	Homo sapiens	135-139
26657646-4	2016	RESULTS: We found that glucocorticoid hormone corticosterone (100, 150, 200 muM) at different time points (48 and 72 hours) induced a dose- and time-dependent reduction in cellular viability as assessed by methyl thiazolyl tetrazolium.	Corticosterone	46-60	latexin	Homo sapiens	76-79
26657646-5	2016	Moreover, glucocorticoid hormone corticosterone (200 muM, 72 hours) decreased the percentage composition of neurons while increasing the percentage of astrocytes as assessed by betaIII-tubulin and glial fibrillary acidic protein immunostaining, respectively.	Corticosterone	33-47	latexin	Homo sapiens	53-56
26657646-6	2016	In contrast, docosahexaenoic acid treatment (6 muM) increased docosahexaenoic acid content and attenuated glucocorticoid hormone corticosterone (200 muM)-induced cell death (72 hours) in cortical cultures.	Corticosterone	129-143	latexin	Homo sapiens	47-50
26657646-6	2016	In contrast, docosahexaenoic acid treatment (6 muM) increased docosahexaenoic acid content and attenuated glucocorticoid hormone corticosterone (200 muM)-induced cell death (72 hours) in cortical cultures.	Corticosterone	129-143	latexin	Homo sapiens	149-152
26657646-8	2016	Furthermore, docosahexaenoic acid (6 muM) reversed glucocorticoid hormone corticosterone-induced neuronal apoptosis as assessed by terminal deoxynucleotidyl transferase-mediated nick-end labeling and attenuated glucocorticoid hormone corticosterone-induced reductions in brain derived neurotrophic factor mRNA expression in these cultures.	Corticosterone	74-88	latexin	Homo sapiens	37-40
26657646-8	2016	Furthermore, docosahexaenoic acid (6 muM) reversed glucocorticoid hormone corticosterone-induced neuronal apoptosis as assessed by terminal deoxynucleotidyl transferase-mediated nick-end labeling and attenuated glucocorticoid hormone corticosterone-induced reductions in brain derived neurotrophic factor mRNA expression in these cultures.	Corticosterone	74-88	brain derived neurotrophic factor	Homo sapiens	271-304
26657646-8	2016	Furthermore, docosahexaenoic acid (6 muM) reversed glucocorticoid hormone corticosterone-induced neuronal apoptosis as assessed by terminal deoxynucleotidyl transferase-mediated nick-end labeling and attenuated glucocorticoid hormone corticosterone-induced reductions in brain derived neurotrophic factor mRNA expression in these cultures.	Corticosterone	234-248	latexin	Homo sapiens	37-40
26657646-9	2016	Finally, docosahexaenoic acid inhibited glucocorticoid hormone corticosterone-induced downregulation of glucocorticoid receptor expression on betaIII- tubulin-positive neurons.	Corticosterone	63-77	nuclear receptor subfamily 3 group C member 1	Homo sapiens	104-127
26915917-0	2016	Differential Regulation of Bcl-xL Gene Expression by Corticosterone, Progesterone, and Retinoic Acid.	Corticosterone	53-67	Bcl2-like 1	Rattus norvegicus	27-33
26915917-2	2016	Mechanistically, CT, PG, and RA induce increases of Bcl-xL protein and mRNA, and activate a 3.2 kb bcl-x gene promoter.	Corticosterone	17-19	Bcl2-like 1	Rattus norvegicus	52-58
26915917-2	2016	Mechanistically, CT, PG, and RA induce increases of Bcl-xL protein and mRNA, and activate a 3.2 kb bcl-x gene promoter.	Corticosterone	17-19	Bcl2-like 1	Rattus norvegicus	99-104
26915917-3	2016	CT and RA, but not PG, induced the activity of a 0.9 kb bcl-x promoter, containing sequences for AP-1 and NF-kB binding.	Corticosterone	0-2	Bcl2-like 1	Rattus norvegicus	56-61
26915917-3	2016	CT and RA, but not PG, induced the activity of a 0.9 kb bcl-x promoter, containing sequences for AP-1 and NF-kB binding.	Corticosterone	0-2	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-101
26915917-3	2016	CT and RA, but not PG, induced the activity of a 0.9 kb bcl-x promoter, containing sequences for AP-1 and NF-kB binding.	Corticosterone	0-2	nuclear factor kappa B subunit 1	Rattus norvegicus	106-111
26915917-5	2016	CT, but not PG or RA, induced AP-1 activation, and induction of the 0.9 kb bcl-x reporter by CT was inhibited by dominant negative c-Jun TAM-67 or removal of AP-1 binding site.	Corticosterone	0-2	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-34
26915917-5	2016	CT, but not PG or RA, induced AP-1 activation, and induction of the 0.9 kb bcl-x reporter by CT was inhibited by dominant negative c-Jun TAM-67 or removal of AP-1 binding site.	Corticosterone	0-2	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	158-162
26808316-3	2016	Chronic stress or corticosterone (CORT) induces a depressive-like phenotype in rodents, including during the postpartum.	Corticosterone	18-32	cortistatin	Rattus norvegicus	34-38
27242463-4	2016	According to the inverted U-shape model of the impact of stress upon learning and memory we hypothesized that glucocorticoid (GR) receptor expression should be correlated to corticosterone levels in a linear or higher order manner.	Corticosterone	174-188	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	110-138
26872221-10	2016	Plasma corticosterone was elevated in ghrelin-O-acyltransferase KO mice and with des-acylated ghrelin administration.	Corticosterone	7-21	membrane bound O-acyltransferase domain containing 4	Mus musculus	38-63
26872221-10	2016	Plasma corticosterone was elevated in ghrelin-O-acyltransferase KO mice and with des-acylated ghrelin administration.	Corticosterone	7-21	ghrelin	Mus musculus	38-45
27271267-0	2016	Forced rather than voluntary exercise entrains peripheral clocks via a corticosterone/noradrenaline increase in PER2::LUC mice.	Corticosterone	71-85	period circadian clock 2	Mus musculus	112-116
26932154-6	2016	The serum corticosterone (CORT) level showed a consistent correlation with glucose levels.	Corticosterone	10-24	cortistatin	Mus musculus	26-30
27060500-5	2016	The results showed that treatment with the 11beta-HSD1 inhibitor PF915275 reversed/alleviated NP-induced hyperadrenalism via the following mechanisms: (1) decreasing serum corticosterone, 11beta-hydroxylase, and aldosterone synthase levels; (2) significantly increasing PPARalpha protein and mRNA expression.	Corticosterone	172-186	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	43-54
27048233-5	2016	Corticosterone (CORT) decreased myotube area, decreased protein synthesis, and increased protein degradation in murine myotubes.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
26675243-8	2016	Intraventricular corticosterone attenuated cocaine self-administration and this effect was blocked in animals pretreated with the GLP-1 receptor antagonist exendin-(9-39) (10 mug) in the VTA.	Corticosterone	17-31	glucagon-like peptide 1 receptor	Rattus norvegicus	130-144
26675243-10	2016	Taken together, these findings indicate that increased activation of NTS GLP-1-expressing neurons by corticosterone may represent a homeostatic response to cocaine taking, thereby reducing the reinforcing efficacy of cocaine.	Corticosterone	101-115	glucagon	Rattus norvegicus	73-78
26926430-0	2016	5-(4-hydroxy-3-dimethoxybenzylidene)-rhodanine (RD-1)-improved mitochondrial function prevents anxiety- and depressive-like states induced by chronic corticosterone injections in mice.	Corticosterone	150-164	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	48-52
26926430-5	2016	Results showed that oral administration with RD-1 at the doses of 25, 50, and 100 mg/kg for five weeks significantly improved the anxiety/depressive-like behavioral changes induced by corticosterone.	Corticosterone	184-198	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	45-49
26926430-10	2016	In conclusion, RD-1 prevents anxiety/depressive-like behavior of mice induced by corticosterone repeated injections with novel mechanism of improvement in the mitochondrial function.	Corticosterone	81-95	phosphodiesterase 6B, cGMP, rod receptor, beta polypeptide	Mus musculus	15-19
27177152-11	2016	These data suggest that MC3-R activation prevents the effect of endotoxin on skeletal wasting by modifying inflammation, corticosterone and IGF-I responses and also by directly acting on muscle cells through the TNFalpha/NF-kappaB(p65) pathway.	Corticosterone	121-135	melanocortin 3 receptor	Rattus norvegicus	24-29
26874256-3	2016	This study aimed to investigate antidepressant-like effect and the possible mechanisms of icariin in a rat model of corticosterone (CORT)-induced depression by using a combination of behavioral and biochemical assessments and NMR-based metabonomics.	Corticosterone	116-130	cortistatin	Rattus norvegicus	132-136
26953322-10	2016	Chronic corticosterone infusion increased bmal1, per1, sgk1, and tsc22d3 expression during the inactive phase.	Corticosterone	8-22	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	42-47
26953322-10	2016	Chronic corticosterone infusion increased bmal1, per1, sgk1, and tsc22d3 expression during the inactive phase.	Corticosterone	8-22	serum/glucocorticoid regulated kinase 1	Homo sapiens	55-59
26953322-10	2016	Chronic corticosterone infusion increased bmal1, per1, sgk1, and tsc22d3 expression during the inactive phase.	Corticosterone	8-22	TSC22 domain family member 3	Homo sapiens	65-72
26874560-9	2016	Blood plasma levels of corticosterone (CORT) were assessed throughout the caffeine consumption procedure in adolescent rats.	Corticosterone	23-37	cortistatin	Rattus norvegicus	39-43
26881836-8	2016	This was observed with concurrent upregulation of 11beta-hydroxysteroid dehydrogenase 1, a local reactivator of corticosterone, in addition to decreased expression of the cytosolic regulatory subunit of superoxide-producing enzyme, NADPH-oxidase.	Corticosterone	112-126	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	50-87
27120588-4	2016	We also showed that the HMF treatment restored (4) corticosterone-induced reductions in neurogenesis in the dentate gyrus subgranular zone and (5) corticosterone-induced reductions in the expression levels of phosphorylated calcium-calmodulin-dependent protein kinase II and extracellular signal-regulated kinase1/2.	Corticosterone	147-161	mitogen-activated protein kinase 3	Mus musculus	275-315
27052887-5	2016	Furthermore, LPM580153 protected the SH-SY5Y cells against the cytotoxic activity of corticosterone, an action that might be related to the role of LPM580153 in increasing the protein levels of BDNF, p-ERK1/2, p-AKT, p-CREB and p-mTOR.	Corticosterone	85-99	brain derived neurotrophic factor	Homo sapiens	194-198
27052887-5	2016	Furthermore, LPM580153 protected the SH-SY5Y cells against the cytotoxic activity of corticosterone, an action that might be related to the role of LPM580153 in increasing the protein levels of BDNF, p-ERK1/2, p-AKT, p-CREB and p-mTOR.	Corticosterone	85-99	mechanistic target of rapamycin kinase	Homo sapiens	230-234
27358119-10	2016	Moreover, the release of ACTH binds the receptor MC2-R and stimulates the generation of glucocorticoids such as corticosterone and cortisol, which interact with the transcription factors AP-1 and NF-kB.	Corticosterone	112-126	proopiomelanocortin	Homo sapiens	25-29
27055260-10	2016	Although experimental conditions were consistent between cohorts, we found that HFD-fed Ins1-/-:Ins2+/- mice with lower insulin levels had increased corticosterone.	Corticosterone	149-163	insulin I	Mus musculus	88-92
27055260-10	2016	Although experimental conditions were consistent between cohorts, we found that HFD-fed Ins1-/-:Ins2+/- mice with lower insulin levels had increased corticosterone.	Corticosterone	149-163	insulin II	Mus musculus	96-100
26901093-1	2016	Mood disorders are associated with dysregulation of prefrontal cortex (PFC) function, circadian rhythms, and diurnal glucocorticoid (corticosterone [CORT]) circulation.	Corticosterone	133-147	cortistatin	Rattus norvegicus	149-153
27358119-10	2016	Moreover, the release of ACTH binds the receptor MC2-R and stimulates the generation of glucocorticoids such as corticosterone and cortisol, which interact with the transcription factors AP-1 and NF-kB.	Corticosterone	112-126	melanocortin 2 receptor	Homo sapiens	49-54
26780087-7	2016	Under acute stress, the increased CS level induced changes in CS-regulated genes expression (CRF and IGF1), while this phenomenon was not observed after chronic stress.	Corticosterone	34-36	insulin-like growth factor 1	Rattus norvegicus	101-105
26744175-3	2016	METHODS: Stress was applied using water avoidance stress (WAS) in the animal model or mimicked using stress hormones, adrenaline (5 nM), and corticosterone (1 muM).	Corticosterone	141-155	latexin	Homo sapiens	159-162
27212922-7	2016	Results from the forced swimming test, open field test, tail suspension test, real-time PCR, enzyme-linked immunosorbent assay, and western blot assay showed that moxibustion treatment decreased mRNA expression of corticotropin-releasing hormone in the hypothalamus, and adrenocorticotropic hormone and corticosterone levels in plasma, and markedly increased progranulin mRNA and protein expression in the hippocampus.	Corticosterone	303-317	corticotropin releasing hormone	Rattus norvegicus	214-245
26821211-6	2016	Consistent with previous studies in the amygdala, sustained corticosterone exposure increases CRH mRNA in the prefrontal cortex.	Corticosterone	60-74	corticotropin releasing hormone	Rattus norvegicus	94-97
26821211-7	2016	As was shown previously, FAAH activity was increased and AEA contents were reduced within the amygdala and prefrontal cortex following chronic corticosterone exposure.	Corticosterone	143-157	fatty-acid amide hydrolase-like	Rattus norvegicus	25-29
26821211-12	2016	These data indicate that chronic elevations in CRH signaling, as is seen following exposure to chronic elevations in corticosterone or stress, drive persistent changes in eCB function.	Corticosterone	117-131	corticotropin releasing hormone	Rattus norvegicus	47-50
26826594-7	2016	In addition, the increase in serum corticosterone levels and the decrease in hippocampal brain-derived neurotrophic factor (BDNF) levels in corticosterone-treated mice were also ameliorated by apigenin administration.	Corticosterone	140-154	brain derived neurotrophic factor	Mus musculus	89-122
26826594-7	2016	In addition, the increase in serum corticosterone levels and the decrease in hippocampal brain-derived neurotrophic factor (BDNF) levels in corticosterone-treated mice were also ameliorated by apigenin administration.	Corticosterone	140-154	brain derived neurotrophic factor	Mus musculus	124-128
26938655-4	2016	Here we show that the non-circadian nuclear receptor and metabolic sensor Liver X Receptor alpha (LXRalpha) which is known to regulate glucocorticoid production in mice modulates the sex specific circadian pattern of plasma corticosterone.	Corticosterone	224-238	nuclear receptor subfamily 1, group H, member 3	Mus musculus	74-96
26938655-4	2016	Here we show that the non-circadian nuclear receptor and metabolic sensor Liver X Receptor alpha (LXRalpha) which is known to regulate glucocorticoid production in mice modulates the sex specific circadian pattern of plasma corticosterone.	Corticosterone	224-238	nuclear receptor subfamily 1, group H, member 3	Mus musculus	98-106
26938655-5	2016	Lxralpha(-/-) males display a blunted corticosterone profile while females show higher amplitude as compared to wild type animals.	Corticosterone	38-52	nuclear receptor subfamily 1, group H, member 3	Mus musculus	0-8
26696124-7	2016	Leptin treatment reduced plasma corticosterone, glucagon, beta-hydroxybutyrate, triglycerides, cholesterol, fatty acids and glycerol.	Corticosterone	32-46	leptin	Mus musculus	0-6
26559325-5	2016	RESULTS: PF670462 or corticosterone (or dexamethasone) suppressed IgE-mediated allergic reactions in mouse bone marrow-derived mast cells or basophils and passive cutaneous anaphylactic reactions in mice in association with increased PER2 levels in mast cells or basophils.	Corticosterone	21-35	period circadian clock 2	Mus musculus	234-238
26697722-0	2016	Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice.	Corticosterone	0-14	KiSS-1 metastasis-suppressor	Mus musculus	71-81
26697722-3	2016	Ovarian cyclicity was monitored in female mice implanted with a cholesterol or corticosterone (Cort) pellet.	Corticosterone	79-93	cortistatin	Mus musculus	95-99
26709611-6	2016	Corticosterone stimulated astrocyte glutamate recycling by increasing glutamate uptake and glutamine synthetase (GS), and altered the astrocyte cytoskeleton.	Corticosterone	0-14	glutamate-ammonia ligase	Rattus norvegicus	91-111
26724742-12	2016	Corticosterone at ~10nM reduced NHE1 and AQP4 expression in mixed glial and pure microglial cultures.	Corticosterone	0-14	solute carrier family 9 member A1	Rattus norvegicus	32-36
26724742-12	2016	Corticosterone at ~10nM reduced NHE1 and AQP4 expression in mixed glial and pure microglial cultures.	Corticosterone	0-14	aquaporin 4	Rattus norvegicus	41-45
26724742-15	2016	These results suggest that the stressful short-period and slow-paced treadmill exercise suppressed NHE1 and AQP4 expression resulting in the amelioration of brain edema at least partly via the moderate increase in plasma corticosterone levels.	Corticosterone	221-235	solute carrier family 9 member A1	Rattus norvegicus	99-103
26724742-15	2016	These results suggest that the stressful short-period and slow-paced treadmill exercise suppressed NHE1 and AQP4 expression resulting in the amelioration of brain edema at least partly via the moderate increase in plasma corticosterone levels.	Corticosterone	221-235	aquaporin 4	Rattus norvegicus	108-112
26391064-5	2016	The goal of this study was to examine the long-term effects of maternal postpartum corticosterone (CORT, a model of postpartum stress/depression) and concurrent maternal postpartum fluoxetine on behavioral, endocrine, and neural measures in adult male and female offspring.	Corticosterone	83-97	cortistatin	Homo sapiens	99-103
26712002-1	2016	Unique among the nuclear receptor superfamily, the glucocorticoid (GC) receptor (GR) can exert three distinct transcriptional regulatory functions on binding of a single natural (cortisol in human and corticosterone in mice) and synthetic [e.g., dexamethasone (Dex)] hormone.	Corticosterone	201-215	nuclear receptor subfamily 3 group C member 1	Homo sapiens	51-79
26019053-6	2016	Mecp2(+/-) mutants displayed elevated corticosterone despite decreased Crh expression, demonstrating hypothalamic-pituitary-adrenal axis dysregulation.	Corticosterone	38-52	methyl CpG binding protein 2	Mus musculus	0-5
26019053-7	2016	EE of Mecp2(+/-) mice normalized basal serum corticosterone and hippocampal BDNF protein levels.	Corticosterone	45-59	methyl CpG binding protein 2	Mus musculus	6-11
26524719-5	2016	In this review, we present the hypothesis that corticosterone physiology mediates flexibility in breeding initiation (the "CORT-Flexibility Hypothesis"), and propose six possible corticosterone-driven mechanisms in pre-breeding birds that may delay breeding initiation: altering hormone titers, negative feedback regulation, plasma binding globulin concentrations, intracellular receptor concentrations, enzyme activity and interacting hormone systems.	Corticosterone	47-61	cortistatin	Homo sapiens	123-127
26568535-8	2016	We also found that Npy1 and Npy5 receptor mRNA expression, genes implicated in appetite regulation, was significantly reduced in the ventral medial hypothalamus of corticosterone-treated males and females compared to controls.	Corticosterone	164-178	neuropeptide Y receptor Y1	Rattus norvegicus	19-23
26590791-6	2016	Corticosterone (CORT) levels were significantly elevated in PACAP-treated rats following fear conditioning, but not at the time of testing (Day 1).	Corticosterone	0-14	adenylate cyclase activating polypeptide 1	Rattus norvegicus	60-65
26590791-6	2016	Corticosterone (CORT) levels were significantly elevated in PACAP-treated rats following fear conditioning, but not at the time of testing (Day 1).	Corticosterone	16-20	adenylate cyclase activating polypeptide 1	Rattus norvegicus	60-65
26630389-6	2016	Furthermore, under basal and stress conditions, activation of adBNST CRF-R1 increased plasma ACTH and corticosterone concentrations, whereas stimulation of adBNST CRF-R2 increased basal plasma ACTH and corticosterone concentrations, but blocked the stress-induced increase in plasma corticosterone secretion.	Corticosterone	102-116	corticotropin releasing hormone receptor 1	Rattus norvegicus	69-75
26630389-6	2016	Furthermore, under basal and stress conditions, activation of adBNST CRF-R1 increased plasma ACTH and corticosterone concentrations, whereas stimulation of adBNST CRF-R2 increased basal plasma ACTH and corticosterone concentrations, but blocked the stress-induced increase in plasma corticosterone secretion.	Corticosterone	202-216	corticotropin releasing hormone receptor 2	Rattus norvegicus	163-169
26630389-6	2016	Furthermore, under basal and stress conditions, activation of adBNST CRF-R1 increased plasma ACTH and corticosterone concentrations, whereas stimulation of adBNST CRF-R2 increased basal plasma ACTH and corticosterone concentrations, but blocked the stress-induced increase in plasma corticosterone secretion.	Corticosterone	202-216	corticotropin releasing hormone receptor 2	Rattus norvegicus	163-169
26630389-7	2016	Moreover, both the CRF-R1 and -R2 antagonists prevented the stress-induced increase in plasma corticosterone secretion.	Corticosterone	94-108	corticotropin releasing hormone receptor 1	Rattus norvegicus	19-33
26630389-8	2016	Importantly, elevated levels of circulating corticosterone induced by intra-adBNST administration of CRF-R1 or -R2 agonist did not impact maternal care.	Corticosterone	44-58	corticotropin releasing hormone receptor 1	Rattus norvegicus	101-107
26658172-6	2016	With this in mind, in the present study, we assessed the effects of intranasal and intraperitoneal oxytocin and GRP administration on social interaction and release of corticosterone in rats.	Corticosterone	168-182	oxytocin/neurophysin I prepropeptide	Homo sapiens	99-107
26658172-6	2016	With this in mind, in the present study, we assessed the effects of intranasal and intraperitoneal oxytocin and GRP administration on social interaction and release of corticosterone in rats.	Corticosterone	168-182	gastrin releasing peptide	Rattus norvegicus	112-115
26658172-8	2016	In addition, while intranasal oxytocin (20 mug) had no effect on blood corticosterone levels, a marked increase in blood corticosterone levels was observed following intraperitoneal oxytocin administration.	Corticosterone	121-135	oxytocin/neurophysin I prepropeptide	Homo sapiens	182-190
26836772-7	2016	However, OXT, but not OXT-A, pretreatment prevented the functional coupling, usually seen in the absence of OXT, between paraventricular nucleus (PVN) activity as measured by c-Fos immunoreactivity and HPA output (i.e. corticosterone release).	Corticosterone	219-233	oxytocin-neurophysin 1	Microtus ochrogaster	9-12
26100539-9	2016	Further, short-term C-SERT-siRNA reversed depressive-like behaviors in corticosterone-treated mice.	Corticosterone	71-85	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	22-26
26850477-13	2016	GPx-1 overexpressing transgenic mice significantly protected increases in the c-Fos-IR and corticosterone level induced by ARS.	Corticosterone	91-105	glutathione peroxidase 1	Mus musculus	0-5
27183712-5	2016	One point seven microg/ml (5 microM) corticosterone served as positive control and was able to reduce LPS-induced IL-6 release by 46 +- 4%.	Corticosterone	37-51	interleukin 6	Mus musculus	114-118
26806035-4	2016	In addition, among PSD mice, TGFbeta1, an anti-inflammatory cytokine, was increased in pre-frontal cortex, liver, and spleen in conjunction with elevated serum corticosterone concentration relative to home-cage controls.	Corticosterone	160-174	transforming growth factor, beta 1	Mus musculus	29-37
26680735-11	2016	Central apelin-13 administration increased the plasma corticosterone and inhibited GE and CT by attenuating antral and colonic contractions.	Corticosterone	54-68	apelin	Rattus norvegicus	8-14
26646204-3	2016	Herein the role of the endogenous corticosterone rhythm on the pattern of GLP-1 and insulin nutrient-induced responses was examined in corticosterone pellet-implanted rats.	Corticosterone	34-48	glucagon	Rattus norvegicus	74-79
26556064-2	2016	However, slight elevations in corticosterone (CORT) - the major stress hormone in rodents - have also been associated with improved performances, albeit in a sex-dependent manner.	Corticosterone	30-44	cortistatin	Rattus norvegicus	46-50
26758842-3	2016	Corticosterone (CORT) is known to negatively correlate with hippocampal neurogenesis, yet its effects on olfactory neurogenesis and olfaction remain unknown.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
26844246-2	2016	The current studies showed this principal by demonstrating that exposure to the stress hormone corticosterone (CORT) allowed behavioral and neurogenic effects to emerge following chronic treatment with fluoxetine of C57BL/6 mice, a strain ordinarily resistant to these effects.	Corticosterone	95-109	cortistatin	Mus musculus	111-115
26741814-4	2016	Lack of CBG does not modify the progression of inflammation associated to pancreatitis but resulted in the loss of gender differences in corticosterone serum levels.	Corticosterone	137-151	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	8-11
26741814-6	2016	Reduced expression of 11beta-HSD2, the enzyme involved in the deactivation of corticosterone, was also observed.	Corticosterone	78-92	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	22-33
27195053-0	2016	Local corticosterone activation by 11beta-hydroxysteroid dehydrogenase 1 in keratinocytes: the role in narrow-band UVB-induced dermatitis.	Corticosterone	6-20	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	35-72
26315459-7	2016	Overexpressing TrkB in the NAc increased the number of young neuronal cells and decreased despair and basal corticosterone levels.	Corticosterone	108-122	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	15-19
27374287-0	2016	Corticosterone Inhibits the Proliferation of C6 Glioma Cells via the Translocation of Unphosphorylated Glucocorticoid Receptor.	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	103-126
27374287-3	2016	Corticosterone (CORT), which is often referred to as the stress hormone, is a well-known regulator of peripheral immune responses and also shows anti-inflammatory properties in the brain.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
26631585-3	2016	Co-cultures were pre-exposed to vehicle or corticosterone (CORT; 1 muM) for 5 days prior to a 24 h co-exposure to NMDA (200 muM).	Corticosterone	59-63	latexin	Homo sapiens	67-70
26342968-1	2016	High population density is often associated with increased levels of stress-related hormones, such as corticosterone (CORT).	Corticosterone	102-116	cortistatin	Microtus ochrogaster	118-122
26519758-4	2016	We showed that the association between levels of IGF-1 and corticosterone depended on physiological condition of nestlings.	Corticosterone	59-73	insulin-like growth factor I	Parus major	49-54
26519758-6	2016	Furthermore, we showed that the interaction between levels of IGF-1 and corticosterone was also related with the survival of the nestlings.	Corticosterone	72-86	insulin-like growth factor I	Parus major	62-67
26122287-8	2016	Across groups, Oxtr transcript levels in the hypothalamus were associated with reduced corticosterone secretion in response to stress, congruent with the role of oxytocin signaling in this region.	Corticosterone	87-101	oxytocin receptor	Rattus norvegicus	15-19
27815456-7	2016	RESULTS: As expected, all four assay kits could detect higher serum CORT levels in mice treated with adrenocorticotropic hormone (ACTH), compared to untreated mice.	Corticosterone	68-72	pro-opiomelanocortin-alpha	Mus musculus	101-128
27815456-7	2016	RESULTS: As expected, all four assay kits could detect higher serum CORT levels in mice treated with adrenocorticotropic hormone (ACTH), compared to untreated mice.	Corticosterone	68-72	pro-opiomelanocortin-alpha	Mus musculus	130-134
26528943-6	2016	Hence, it is likely that an increase in corticosterone levels (stress response) induced by moderate exercise increased intestinal IgA levels by enabling greater liver expression of pIgR mRNA, leading to a rise in IgA transcytosis from the liver to intestine.	Corticosterone	40-54	immunoglobulin heavy constant alpha	Mus musculus	130-133
26528943-6	2016	Hence, it is likely that an increase in corticosterone levels (stress response) induced by moderate exercise increased intestinal IgA levels by enabling greater liver expression of pIgR mRNA, leading to a rise in IgA transcytosis from the liver to intestine.	Corticosterone	40-54	polymeric immunoglobulin receptor	Mus musculus	181-185
26528943-6	2016	Hence, it is likely that an increase in corticosterone levels (stress response) induced by moderate exercise increased intestinal IgA levels by enabling greater liver expression of pIgR mRNA, leading to a rise in IgA transcytosis from the liver to intestine.	Corticosterone	40-54	immunoglobulin heavy constant alpha	Mus musculus	213-216
27432231-6	2016	Serum corticosterone level was markedly increased by Abeta injection.	Corticosterone	6-20	amyloid beta (A4) precursor protein	Mus musculus	53-58
26610754-10	2016	The changes in the adrenal gland and plasma concentration of steroids were thought to reflect inhibited metabolism of deoxycorticosterone to corticosterone through inhibition of CYP11B1, and compensatory reaction for the inhibition.	Corticosterone	123-137	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	178-185
27871077-12	2016	CONCLUSION: Annexin A7 deficiency upregulates FGF23 plasma levels, an effect paralleled by increased corticosterone plasma levels, as well as decreased 1,25(OH)2 D3 and PTH plasma levels.	Corticosterone	101-115	annexin A7	Mus musculus	12-22
26690871-3	2016	PURPOSE: During acute and chronic stress, corticotropin-releasing hormone drives secretion of adrenocorticotropic hormone from the pituitary, ultimately leading to the release of cortisol (human) and corticosterone (rodent) from the adrenal glands.	Corticosterone	200-214	corticotropin releasing hormone	Homo sapiens	42-73
26454419-3	2016	Here, we found that adult male rats treated with corticosterone (CORT, 100 mug/ml) via the drinking water for 21 days indeed show increased TPH2 protein expression in the dorsal and ventral part of the dorsal raphe nucleus (DRD, DRV) during the light phase, abolishing the enzyme"s diurnal rhythm.	Corticosterone	49-63	tryptophan hydroxylase 2	Rattus norvegicus	140-144
26454419-3	2016	Here, we found that adult male rats treated with corticosterone (CORT, 100 mug/ml) via the drinking water for 21 days indeed show increased TPH2 protein expression in the dorsal and ventral part of the dorsal raphe nucleus (DRD, DRV) during the light phase, abolishing the enzyme"s diurnal rhythm.	Corticosterone	65-69	tryptophan hydroxylase 2	Rattus norvegicus	140-144
26569535-5	2016	Furthermore, the antidepressant actions of AICAR required endothelial nitric oxide synthase activity with increased NO production in the prefrontal cortex, whereas corticosterone-induced expression of neuronal nitric oxide synthase and NO production may increase the risk of depression.	Corticosterone	164-178	nitric oxide synthase 1, neuronal	Mus musculus	201-231
26437348-6	2016	Corticosterone was quantified using ELISA and LCMS, and was found in the biosolids, tap water, wastewater effluent and lettuce plants.	Corticosterone	0-14	nuclear RNA export factor 1	Homo sapiens	84-87
26350703-0	2015	Reversal of corticosterone-induced BDNF alterations by the natural antioxidant alpha-lipoic acid alone and combined with desvenlafaxine: Emphasis on the neurotrophic hypothesis of depression.	Corticosterone	12-26	brain derived neurotrophic factor	Mus musculus	35-39
26881748-10	2016	In addition, LPS induced anorexia and increased serum corticosterone levels.	Corticosterone	54-68	toll-like receptor 4	Mus musculus	13-16
26881748-12	2016	Pifithrin-mu also prevented the formation of anorexia as well as the increase in serum corticosterone levels in LPS-treated mice.	Corticosterone	87-101	toll-like receptor 4	Mus musculus	112-115
26649066-0	2015	Compared to casein, bovine lactoferrin reduces plasma leptin and corticosterone and affects hypothalamic gene expression without altering weight gain or fat mass in high fat diet fed C57/BL6J mice.	Corticosterone	65-79	lactotransferrin	Bos taurus	27-38
26649066-12	2015	Notably, plasma corticosterone levels in the HFD + Lac group were reduced compared to the HFD fed mice (P &lt; 0.05).	Corticosterone	16-30	lactase	Mus musculus	51-54
26649066-15	2015	The lactoferrin fed mouse model could be used to identify leptin and corticosterone regulated genes in the hypothalamus without the confounding effects of body weight change.	Corticosterone	69-83	lactotransferrin	Mus musculus	4-15
27220240-3	2016	The expression of corticotrophin-releasing hormone (CRH) in the hypothalamic paraventricular nucleus (PVN) increases, coupled with a rise in plasma levels of ACTH and corticosterone as well as in adrenal weight.	Corticosterone	167-181	corticotropin releasing hormone	Rattus norvegicus	18-50
27220240-3	2016	The expression of corticotrophin-releasing hormone (CRH) in the hypothalamic paraventricular nucleus (PVN) increases, coupled with a rise in plasma levels of ACTH and corticosterone as well as in adrenal weight.	Corticosterone	167-181	corticotropin releasing hormone	Rattus norvegicus	52-55
26733815-8	2015	Conversely, the expression of Cx43 was assessed in the hippocampus of mice subjected to prolonged corticosterone (CORT) exposure, given either alone or in combination with an antidepressant drug, the selective serotonin reuptake inhibitor fluoxetine.	Corticosterone	98-112	gap junction protein, alpha 3	Mus musculus	30-34
26733815-8	2015	Conversely, the expression of Cx43 was assessed in the hippocampus of mice subjected to prolonged corticosterone (CORT) exposure, given either alone or in combination with an antidepressant drug, the selective serotonin reuptake inhibitor fluoxetine.	Corticosterone	98-112	cortistatin	Mus musculus	114-118
26350703-8	2015	The combination of DVS and ALA200 reversed CORT-induced alterations in BDNF and even, in some cases, increased the levels of this neurotrophin when compared to vehicle-treated animals in HC and ST. Taken together, these results suggest that the combination of the DVS+ALA may be valuable for treating conditions in which BDNF levels are decreased, such as depression.	Corticosterone	43-47	brain derived neurotrophic factor	Mus musculus	71-75
26585788-14	2015	CONCLUSIONS: Taken together, our findings show that (1) loss of PKR could alter E. coli-induced sickness behaviors and (2) this was unlikely to be due to exacerbated neuroimmune activation, (3) elevated bacterial load, or (4) dysregulation in the corticosterone response.	Corticosterone	247-261	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	64-67
26616869-5	2015	Furthermore, 4-MeH treatment of stressed mice led to an increase in the levels of serum Th1/Th17 cytokines and corticosterone, and a decrease in Th2 cytokines.	Corticosterone	111-125	epoxide hydrolase 1, microsomal	Mus musculus	15-18
26297350-9	2015	Moreover, the AS rats showed increased plasma concentration and hypothalamic mRNA expression of nesfatin-1, which were positively correlated with the plasma corticosterone concentration and hypothalamic CRH expression, respectively.	Corticosterone	157-171	nucleobindin 2	Rattus norvegicus	96-106
26627259-6	2015	We also show that the reported corticosterone extraproduction during the RF active phase reflects an adrenal aberrant activation of CREB signaling, which selectively delays the activation of the PPARalpha-RevErbalpha axis in muscle and heart and accounts for the retarded shift of their PCCs.	Corticosterone	31-45	cAMP responsive element binding protein 1	Mus musculus	132-136
26627259-6	2015	We also show that the reported corticosterone extraproduction during the RF active phase reflects an adrenal aberrant activation of CREB signaling, which selectively delays the activation of the PPARalpha-RevErbalpha axis in muscle and heart and accounts for the retarded shift of their PCCs.	Corticosterone	31-45	peroxisome proliferator activated receptor alpha	Mus musculus	195-204
26627259-6	2015	We also show that the reported corticosterone extraproduction during the RF active phase reflects an adrenal aberrant activation of CREB signaling, which selectively delays the activation of the PPARalpha-RevErbalpha axis in muscle and heart and accounts for the retarded shift of their PCCs.	Corticosterone	31-45	nuclear receptor subfamily 1, group D, member 1	Mus musculus	205-216
26092248-7	2015	In addition, CTSD HET mice display stress-induced hypersecretion of corticosterone.	Corticosterone	68-82	cathepsin D	Mus musculus	13-17
26575223-3	2015	In this study, we examined whether miRNAs and associated gene networks have a role in chronic corticosterone (CORT; 50 mg  kg(-1) x 21 days)-mediated depression in rats.	Corticosterone	94-108	cortistatin	Rattus norvegicus	110-114
26498359-4	2015	Still, the manuscripts suggest seemingly contradictory roles of endogenous GILZ: one of them suggested compensatory actions by elevated corticosterone levels in GILZ knockout mice, while our own manuscript showed a distinct phenotype upon GILZ knockout in vivo.	Corticosterone	136-150	TSC22 domain family, member 3	Mus musculus	75-79
26498359-4	2015	Still, the manuscripts suggest seemingly contradictory roles of endogenous GILZ: one of them suggested compensatory actions by elevated corticosterone levels in GILZ knockout mice, while our own manuscript showed a distinct phenotype upon GILZ knockout in vivo.	Corticosterone	136-150	TSC22 domain family, member 3	Mus musculus	161-165
26498359-4	2015	Still, the manuscripts suggest seemingly contradictory roles of endogenous GILZ: one of them suggested compensatory actions by elevated corticosterone levels in GILZ knockout mice, while our own manuscript showed a distinct phenotype upon GILZ knockout in vivo.	Corticosterone	136-150	TSC22 domain family, member 3	Mus musculus	161-165
26537115-11	2015	RS caused a higher increase in corticosterone levels in adult Fgf8 (+/neo) mice than in WT mice after 15 min, but no difference was seen after 45 min.	Corticosterone	31-45	fibroblast growth factor 8	Mus musculus	62-66
26572647-5	2015	Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping-but not on the mobile fraction-and synaptic transmission.	Corticosterone	83-97	mechanistic target of rapamycin kinase	Homo sapiens	13-42
26572647-5	2015	Blocking the mammalian target of rapamycin (mTOR) pathway prevented the effects of corticosterone on both AMPAR trapping-but not on the mobile fraction-and synaptic transmission.	Corticosterone	83-97	mechanistic target of rapamycin kinase	Homo sapiens	44-48
26572647-6	2015	Blocking the mTOR pathway also prevented the memory enhancing effects of corticosterone in a contextual fear-conditioning paradigm.	Corticosterone	73-87	mechanistic target of rapamycin kinase	Homo sapiens	13-17
26572647-7	2015	We conclude that activation of the mTOR pathway is essential for the effects of corticosterone on synaptic trapping of AMPARs and, possibly as a consequence, fearful memory formation.	Corticosterone	80-94	mechanistic target of rapamycin kinase	Homo sapiens	35-39
26617502-2	2015	The expression of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA2, which is important for synaptic plasticity and memory, is increased with corticosterone (CORT), undermining synaptic plasticity and memory.	Corticosterone	183-197	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	103-108
26617502-2	2015	The expression of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit GluA2, which is important for synaptic plasticity and memory, is increased with corticosterone (CORT), undermining synaptic plasticity and memory.	Corticosterone	183-197	cortistatin	Rattus norvegicus	199-203
26617482-5	2015	The results showed that both acute and chronic administration of nesfatin-1 increased immobility in the forced swimming test (FST), and resulted in the hyperactivity of HPA axis, as indicated by the increase of plasma corticosterone concentration and hypothalamic expression of corticotropin-releasing hormone (CRH) mRNA.	Corticosterone	218-232	nucleobindin 2	Rattus norvegicus	65-75
26617482-7	2015	Furthermore, chronic administration of nesfatin-1 elevated plasma concentrations of IL-6 and CRP, which were positively correlated with despair behavior, plasma corticosterone level, and the hypothalamic mRNA expression of synapsin I and synaptotagmin I.	Corticosterone	161-175	nucleobindin 2	Rattus norvegicus	39-49
26617482-7	2015	Furthermore, chronic administration of nesfatin-1 elevated plasma concentrations of IL-6 and CRP, which were positively correlated with despair behavior, plasma corticosterone level, and the hypothalamic mRNA expression of synapsin I and synaptotagmin I.	Corticosterone	161-175	interleukin 6	Rattus norvegicus	84-88
26617482-7	2015	Furthermore, chronic administration of nesfatin-1 elevated plasma concentrations of IL-6 and CRP, which were positively correlated with despair behavior, plasma corticosterone level, and the hypothalamic mRNA expression of synapsin I and synaptotagmin I.	Corticosterone	161-175	C-reactive protein	Rattus norvegicus	93-96
26331981-9	2015	These findings reveal that some MUPs, especially Mup20, might constitute potential dominance pheromones and could be downregulated by hepatic CRHR2, which is possibly independent of androgen or corticosterone systems.	Corticosterone	194-208	major urinary protein 20	Mus musculus	49-54
26362633-5	2015	Measurements of adrenal CYP11B2 expression and plasma aldosterone levels showed that increases in endogenous (obesity) or exogenous (infusion) leptin dose-dependently raised CYP11B2 expression and aldosterone without elevating plasma angiotensin II, potassium or corticosterone.	Corticosterone	263-277	leptin	Homo sapiens	143-149
26513007-8	2015	The increases in corticosterone concentrations paralleled changes in the abundance of ubiquitinated proteins and the autophagic proteins LC3 and p62/SQSTM1, suggesting that corticosterone may trigger these changes.	Corticosterone	17-31	annexin A3	Rattus norvegicus	137-140
26513007-8	2015	The increases in corticosterone concentrations paralleled changes in the abundance of ubiquitinated proteins and the autophagic proteins LC3 and p62/SQSTM1, suggesting that corticosterone may trigger these changes.	Corticosterone	17-31	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	145-148
26513007-8	2015	The increases in corticosterone concentrations paralleled changes in the abundance of ubiquitinated proteins and the autophagic proteins LC3 and p62/SQSTM1, suggesting that corticosterone may trigger these changes.	Corticosterone	17-31	sequestosome 1	Rattus norvegicus	149-155
26513007-8	2015	The increases in corticosterone concentrations paralleled changes in the abundance of ubiquitinated proteins and the autophagic proteins LC3 and p62/SQSTM1, suggesting that corticosterone may trigger these changes.	Corticosterone	173-187	annexin A3	Rattus norvegicus	137-140
26513007-8	2015	The increases in corticosterone concentrations paralleled changes in the abundance of ubiquitinated proteins and the autophagic proteins LC3 and p62/SQSTM1, suggesting that corticosterone may trigger these changes.	Corticosterone	173-187	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	145-148
26513007-8	2015	The increases in corticosterone concentrations paralleled changes in the abundance of ubiquitinated proteins and the autophagic proteins LC3 and p62/SQSTM1, suggesting that corticosterone may trigger these changes.	Corticosterone	173-187	sequestosome 1	Rattus norvegicus	149-155
26209808-7	2015	We show that microglia and brain-macrophages from corticosterone-treated mice adopt differential expression profiles for CCR2, MHC class II and IL-4recalpha surface markers depending on whether the mice are kept in standard environment or EE.	Corticosterone	50-64	chemokine (C-C motif) receptor 2	Mus musculus	121-125
26209808-7	2015	We show that microglia and brain-macrophages from corticosterone-treated mice adopt differential expression profiles for CCR2, MHC class II and IL-4recalpha surface markers depending on whether the mice are kept in standard environment or EE.	Corticosterone	50-64	interleukin 4	Mus musculus	144-148
26209808-9	2015	When injected intra-cerebroventricularly, ApN, whose level is specifically increased in cerebrospinal fluid of depressive mice raised in EE, rescues microglia phenotype, reduces pro-inflammatory cytokine production by microglia and blocks depressive-like behavior in corticosterone-treated mice.	Corticosterone	267-281	adiponectin, C1Q and collagen domain containing	Mus musculus	42-45
26372178-9	2015	Corticosterone strongly decreased BAT activity: BAT weight increased by 3.5-fold, whereas uncoupling protein 1 (Ucp1) mRNA expression and Ucp1 protein content of BAT were reduced by 75% and 60%, respectively.	Corticosterone	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	90-110
26372178-9	2015	Corticosterone strongly decreased BAT activity: BAT weight increased by 3.5-fold, whereas uncoupling protein 1 (Ucp1) mRNA expression and Ucp1 protein content of BAT were reduced by 75% and 60%, respectively.	Corticosterone	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	112-116
26372178-9	2015	Corticosterone strongly decreased BAT activity: BAT weight increased by 3.5-fold, whereas uncoupling protein 1 (Ucp1) mRNA expression and Ucp1 protein content of BAT were reduced by 75% and 60%, respectively.	Corticosterone	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	138-142
26303746-7	2015	Utilizing both CAH and HAH, we have characterized the kinetics of the CYP11B1-mediated conversion of 11-deoxycortisol to cortisol and the CYP11B2-mediated oxidation of corticosterone to aldosterone.	Corticosterone	168-182	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	138-145
26423115-0	2015	H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway.	Corticosterone	44-58	brain-derived neurotrophic factor	Rattus norvegicus	76-80
26423115-0	2015	H2S protects PC12 cells against toxicity of corticosterone by modulation of BDNF-TrkB pathway.	Corticosterone	44-58	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	81-85
26423115-7	2015	NaHS not only induced the up-regulation of BDNF but also prevented the down-regulation of BDNF by corticosterone.	Corticosterone	98-112	brain-derived neurotrophic factor	Rattus norvegicus	90-94
26423115-8	2015	It was also found that blocking BDNF-TrkB pathway by K252a, an inhibitor of TrkB, abolished the protection of H2S against corticosterone-induced cytotoxicity, apoptosis, accumulation of ROS, and loss of MMP.	Corticosterone	122-136	brain-derived neurotrophic factor	Rattus norvegicus	32-36
26423115-8	2015	It was also found that blocking BDNF-TrkB pathway by K252a, an inhibitor of TrkB, abolished the protection of H2S against corticosterone-induced cytotoxicity, apoptosis, accumulation of ROS, and loss of MMP.	Corticosterone	122-136	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	37-41
26423115-8	2015	It was also found that blocking BDNF-TrkB pathway by K252a, an inhibitor of TrkB, abolished the protection of H2S against corticosterone-induced cytotoxicity, apoptosis, accumulation of ROS, and loss of MMP.	Corticosterone	122-136	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	76-80
26423115-9	2015	These results suggest that H2S protects against the neurotoxicity of corticosterone by modulation of the BDNF-TrkB pathway.	Corticosterone	69-83	brain-derived neurotrophic factor	Rattus norvegicus	105-109
26423115-9	2015	These results suggest that H2S protects against the neurotoxicity of corticosterone by modulation of the BDNF-TrkB pathway.	Corticosterone	69-83	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	110-114
25701840-6	2015	After 3 weeks of treatment, they were hotplate tested again, their uterine horns and brains were harvested, and a blood sample was taken to measure the plasma corticosterone (CORT) level by enzyme-linked immunosorbent assay.	Corticosterone	159-173	cortistatin	Mus musculus	175-179
26388293-6	2015	BDNF siRNA rats exhibited decreased BDNF levels and concomitant altered adrenocortoctrophic hormone (ACTH) and corticosterone responses to restraint stress, suggesting the involvement of BDNF in the HPA axis adaptive response to stress.	Corticosterone	111-125	brain-derived neurotrophic factor	Rattus norvegicus	0-4
26130445-8	2015	Indeed, broilers showed significantly lower levels of plasma corticosterone (CORT) than layers.	Corticosterone	61-75	CORT	Gallus gallus	77-81
26209791-9	2015	Thus, treatment of adrenal cells with low doses of BPA activated Cyp11a1 and increased corticosterone production through the JNK/c-Jun signaling pathway.	Corticosterone	87-101	mitogen-activated protein kinase 8	Homo sapiens	125-128
26209791-9	2015	Thus, treatment of adrenal cells with low doses of BPA activated Cyp11a1 and increased corticosterone production through the JNK/c-Jun signaling pathway.	Corticosterone	87-101	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	129-134
26297864-9	2015	Corticosterone decreased maternal care, plasma oxytocin levels, milk consumption by the pups, the activation of oxytocinergic neurons in hypothalamic nuclei, and c-Fos immunoreactivity in MPOA neurons.	Corticosterone	0-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	162-167
24812291-9	2015	IL-1beta inhibited ACTH-stimulated corticosterone secretion from adrenocortical cells in vitro.	Corticosterone	35-49	interleukin 1 beta	Rattus norvegicus	0-8
25813907-5	2015	ETV5 deficiency increased both pre- and post-stress plasma corticosterone, suggesting that loss of ETV5 elevated glucocorticoid tone.	Corticosterone	59-73	ets variant 5	Mus musculus	0-4
26162700-1	2015	In this study we aimed to test central administration of CDP-choline on serum ghrelin, leptin, glucose and corticosterone levels in rats.	Corticosterone	107-121	cut-like homeobox 1	Rattus norvegicus	57-60
26162700-10	2015	CDP-choline injections also induced a dose- and time-dependent increase in serum glucose and corticosterone levels.	Corticosterone	93-107	cut-like homeobox 1	Rattus norvegicus	0-3
25816736-0	2015	Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model.	Corticosterone	83-97	colony stimulating factor 3	Rattus norvegicus	0-37
25816736-0	2015	Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model.	Corticosterone	83-97	Janus kinase 2	Rattus norvegicus	48-52
25816736-0	2015	Granulocyte-colony stimulating factor activates JAK2/PI3K/PDE3B pathway to inhibit corticosterone synthesis in a neonatal hypoxic-ischemic brain injury rat model.	Corticosterone	83-97	phosphodiesterase 3B	Rattus norvegicus	58-63
25816736-1	2015	OBJECTIVE: Our previous study demonstrated that granulocyte-colony stimulating factor (G-CSF)-induced neuroprotection is accompanied by an inhibition of corticosterone production in a neonatal hypoxic-ischemic (HI) rat model.	Corticosterone	153-167	colony stimulating factor 3	Rattus norvegicus	48-85
25816736-1	2015	OBJECTIVE: Our previous study demonstrated that granulocyte-colony stimulating factor (G-CSF)-induced neuroprotection is accompanied by an inhibition of corticosterone production in a neonatal hypoxic-ischemic (HI) rat model.	Corticosterone	153-167	colony stimulating factor 3	Rattus norvegicus	87-92
25816736-2	2015	The present study investigates how G-CSF inhibits corticosterone production, using adrenal cortical cells and HI rat pups.	Corticosterone	50-64	colony stimulating factor 3	Rattus norvegicus	35-40
25816736-8	2015	RESULTS: G-CSF at 30ng/ml inhibited corticosterone synthesis but lost its inhibitory effect at higher doses.	Corticosterone	36-50	colony stimulating factor 3	Rattus norvegicus	9-14
25816736-10	2015	The degradation of cAMP by G-CSF signaling reduced corticosterone production.	Corticosterone	51-65	colony stimulating factor 3	Rattus norvegicus	27-32
25816736-12	2015	CONCLUSION: Our data suggest that the neuroprotective G-CSF reduces corticosterone synthesis at the adrenal level by degrading intracellular cAMP via activation of the JAK2/PI3K/PDE3B pathway.	Corticosterone	68-82	colony stimulating factor 3	Rattus norvegicus	54-59
25816736-12	2015	CONCLUSION: Our data suggest that the neuroprotective G-CSF reduces corticosterone synthesis at the adrenal level by degrading intracellular cAMP via activation of the JAK2/PI3K/PDE3B pathway.	Corticosterone	68-82	Janus kinase 2	Rattus norvegicus	168-172
25816736-12	2015	CONCLUSION: Our data suggest that the neuroprotective G-CSF reduces corticosterone synthesis at the adrenal level by degrading intracellular cAMP via activation of the JAK2/PI3K/PDE3B pathway.	Corticosterone	68-82	phosphodiesterase 3B	Rattus norvegicus	178-183
26048446-8	2015	Further, there was a significant increase in serum corticosterone level and a significant decrease in hippocampus BDNF level in CORT-treated mice.	Corticosterone	128-132	brain derived neurotrophic factor	Mus musculus	114-118
26374826-6	2015	In contrast, silencing of the CYP11A1 gene did not affect marinobufagenin production in either cell culture, but suppressed production of progesterone 2-fold in human trophoblast cells and of corticosterone by 90% in rat adrenocortical cells when compared with cells transfected with nontargeting siRNA.	Corticosterone	192-206	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	30-37
26246084-4	2015	Here we show that in knockout mice lacking the guanine nucleotide exchange factor, RasGRF1, habituation to 30 min/day of restraint stress is markedly accelerated, such that these mice do not display elevated corticosterone levels or enhanced locomotion after 7 days of stress exposure, like WT mice do.	Corticosterone	208-222	RAS protein-specific guanine nucleotide-releasing factor 1	Mus musculus	83-90
26117716-5	2015	Corticosterone (CORT) concentration in the serum was quantified to examine hypothalamic-pituitary-adrenal axis (HPA-axis) responsiveness.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
26144050-9	2015	Corticosterone has significantly lower Km"s for both 11beta-HSD2 and 11beta-HSD1 enzymatic dehydrogenase activity, compared to cortisol.	Corticosterone	0-14	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	53-64
26136384-6	2015	Strikingly, restoration of adrenal LDLR function significantly reduced the ACTH-mediated stimulation of adrenal steroidogenesis (P&lt;0.001), with plasma corticosterone levels that were respectively 44-59% lower (P&lt;0.01) as compared to adrenal LDLR negative controls.	Corticosterone	154-168	low density lipoprotein receptor	Mus musculus	35-39
26136384-6	2015	Strikingly, restoration of adrenal LDLR function significantly reduced the ACTH-mediated stimulation of adrenal steroidogenesis (P&lt;0.001), with plasma corticosterone levels that were respectively 44-59% lower (P&lt;0.01) as compared to adrenal LDLR negative controls.	Corticosterone	154-168	pro-opiomelanocortin-alpha	Mus musculus	75-79
26136384-7	2015	In addition, LDLR positive adrenal transplanted mice exhibited a significant decrease (-39%; P&lt;0.001) in their plasma corticosterone level under fasting stress conditions.	Corticosterone	121-135	low density lipoprotein receptor	Mus musculus	13-17
26180121-2	2015	We test the hypothesis that stress-induced increases in corticosterone (CORT), the primary rodent glucocorticoid, are the key mediator of stress-induced depressive-like behavioral changes and synaptic dysfunction in the rat hippocampus.	Corticosterone	56-70	cortistatin	Rattus norvegicus	72-76
26070900-3	2015	This study was aimed at investigating the effects of different timing of exercise and exercise withdrawal on memory, and serum and hippocampal corticosterone (CORT) levels.	Corticosterone	143-157	cortistatin	Rattus norvegicus	159-163
26277823-5	2015	Results showed that Rg1 (5mg/kg) treatments relieved PTSD-like behavior by altering elevated serum corticosterone and hypothalamus CRH levels.	Corticosterone	99-113	protein phosphatase 1, regulatory subunit 3A	Mus musculus	20-23
26401072-13	2015	CONCLUSION: Intestinal ACE shedding is increased by DSS-induced intestinal inflammation and parallels local corticosterone production.	Corticosterone	108-122	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	23-26
26401072-14	2015	ACE product angiotensin II stimulates corticosterone formation in healthy intestine.	Corticosterone	38-52	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	0-3
26332732-3	2015	In contrast, Corticosterone could bind and stabilize the hairpin, inducing transformation of the G-quadruplex into the hairpin, resulting in up-regulation of hnRNP K gene transcription.	Corticosterone	13-27	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	158-165
26142564-1	2015	Sensitivity to the interoceptive effects of alcohol is blunted following a period of exposure to the stress hormone corticosterone (CORT), an effect that is suggested to be related, in part, to glutamatergic neuroadaptations.	Corticosterone	116-130	cortistatin	Rattus norvegicus	132-136
26121342-3	2015	Superimposed corticosterone pulses inhibited CRH-stimulated ACTH release, depending on prior glucocorticoid clearance.	Corticosterone	13-27	corticotropin releasing hormone	Mus musculus	45-48
26121342-3	2015	Superimposed corticosterone pulses inhibited CRH-stimulated ACTH release, depending on prior glucocorticoid clearance.	Corticosterone	13-27	pro-opiomelanocortin-alpha	Mus musculus	60-64
26121342-4	2015	When CRH perifusion started after 2 hours of glucocorticoid-free medium, corticosterone levels in the stress range (1 muM) caused a delayed (25 min) and prolonged inhibition of CRH-stimulated ACTH secretion, up to 60 minutes after corticosterone withdrawal.	Corticosterone	73-87	corticotropin releasing hormone	Mus musculus	5-8
26121342-4	2015	When CRH perifusion started after 2 hours of glucocorticoid-free medium, corticosterone levels in the stress range (1 muM) caused a delayed (25 min) and prolonged inhibition of CRH-stimulated ACTH secretion, up to 60 minutes after corticosterone withdrawal.	Corticosterone	73-87	corticotropin releasing hormone	Mus musculus	177-180
26121342-4	2015	When CRH perifusion started after 2 hours of glucocorticoid-free medium, corticosterone levels in the stress range (1 muM) caused a delayed (25 min) and prolonged inhibition of CRH-stimulated ACTH secretion, up to 60 minutes after corticosterone withdrawal.	Corticosterone	73-87	pro-opiomelanocortin-alpha	Mus musculus	192-196
26121342-4	2015	When CRH perifusion started after 2 hours of glucocorticoid-free medium, corticosterone levels in the stress range (1 muM) caused a delayed (25 min) and prolonged inhibition of CRH-stimulated ACTH secretion, up to 60 minutes after corticosterone withdrawal.	Corticosterone	231-245	corticotropin releasing hormone	Mus musculus	5-8
26121342-4	2015	When CRH perifusion started after 2 hours of glucocorticoid-free medium, corticosterone levels in the stress range (1 muM) caused a delayed (25 min) and prolonged inhibition of CRH-stimulated ACTH secretion, up to 60 minutes after corticosterone withdrawal.	Corticosterone	231-245	corticotropin releasing hormone	Mus musculus	177-180
26121342-4	2015	When CRH perifusion started after 2 hours of glucocorticoid-free medium, corticosterone levels in the stress range (1 muM) caused a delayed (25 min) and prolonged inhibition of CRH-stimulated ACTH secretion, up to 60 minutes after corticosterone withdrawal.	Corticosterone	231-245	pro-opiomelanocortin-alpha	Mus musculus	192-196
26121342-5	2015	In contrast, after 6 hours of glucocorticoid-free medium, basal corticosterone levels inhibited CRH-stimulated ACTH within 5 minutes, after rapid recovery 5 minutes after corticosterone withdrawal.	Corticosterone	64-78	corticotropin releasing hormone	Mus musculus	96-99
26121342-5	2015	In contrast, after 6 hours of glucocorticoid-free medium, basal corticosterone levels inhibited CRH-stimulated ACTH within 5 minutes, after rapid recovery 5 minutes after corticosterone withdrawal.	Corticosterone	64-78	pro-opiomelanocortin-alpha	Mus musculus	111-115
26121342-5	2015	In contrast, after 6 hours of glucocorticoid-free medium, basal corticosterone levels inhibited CRH-stimulated ACTH within 5 minutes, after rapid recovery 5 minutes after corticosterone withdrawal.	Corticosterone	171-185	corticotropin releasing hormone	Mus musculus	96-99
26121342-7	2015	In hypothalamic-derived 4B cells, 10 nM corticosterone increased immunoreactive glucocorticoid receptor content in membrane fractions, with association and clearance rates paralleling the effects on ACTH secretion from corticotrophs.	Corticosterone	40-54	nuclear receptor subfamily 3, group C, member 1	Mus musculus	80-103
26121342-7	2015	In hypothalamic-derived 4B cells, 10 nM corticosterone increased immunoreactive glucocorticoid receptor content in membrane fractions, with association and clearance rates paralleling the effects on ACTH secretion from corticotrophs.	Corticosterone	40-54	pro-opiomelanocortin-alpha	Mus musculus	199-203
26121342-8	2015	Corticosterone did not affect CRH-stimulated calcium influx, but in AtT-20 cells, it had biphasic effects on CRH-stimulated Src phosphorylation, with early inhibition and late stimulation, suggesting a role for Src phosphorylation on the rapid glucocorticoid feedback.	Corticosterone	0-14	corticotropin releasing hormone	Mus musculus	109-112
26121342-8	2015	Corticosterone did not affect CRH-stimulated calcium influx, but in AtT-20 cells, it had biphasic effects on CRH-stimulated Src phosphorylation, with early inhibition and late stimulation, suggesting a role for Src phosphorylation on the rapid glucocorticoid feedback.	Corticosterone	0-14	Rous sarcoma oncogene	Mus musculus	124-127
26121342-8	2015	Corticosterone did not affect CRH-stimulated calcium influx, but in AtT-20 cells, it had biphasic effects on CRH-stimulated Src phosphorylation, with early inhibition and late stimulation, suggesting a role for Src phosphorylation on the rapid glucocorticoid feedback.	Corticosterone	0-14	Rous sarcoma oncogene	Mus musculus	211-214
23363575-8	2015	The levels of Fas and FasL proteins were also increased in rats subjected to either TCDD or corticosterone treatment.	Corticosterone	92-106	Fas ligand	Rattus norvegicus	22-26
26305481-3	2015	Of these, 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1), which is responsible for the conversion of inert cortisone (11-dehydrocorticosterone, DHC in rodents) to active cortisol (corticosterone) in the liver and adipose tissues, has not been identified previously as an IGF-I target in pancreatic islets.	Corticosterone	133-147	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	49-60
26305481-3	2015	Of these, 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1), which is responsible for the conversion of inert cortisone (11-dehydrocorticosterone, DHC in rodents) to active cortisol (corticosterone) in the liver and adipose tissues, has not been identified previously as an IGF-I target in pancreatic islets.	Corticosterone	133-147	insulin-like growth factor 1	Mus musculus	276-281
26071542-2	2015	Since endogenous ANG II in the PVN modulates stress reactivity, we tested the hypothesis that replacement of MIF in PVN neurons would reduce baseline blood pressure and inhibit stress-induced increases in blood pressure and plasma corticosterone in adult male SHRs.	Corticosterone	231-245	macrophage migration inhibitory factor	Rattus norvegicus	109-112
26071542-5	2015	MIF treatment in the PVN attenuated average restraint-induced increases in blood pressure (37.4 +- 2.0 and 27.6 +- 3.5 mmHg in GFP and MIF groups, respectively, P &lt; 0.05) and corticosterone (42 +- 2 and 36 +- 3 mug/dl in GFP and MIF groups, respectively, P &lt; 0.05).	Corticosterone	178-192	macrophage migration inhibitory factor	Rattus norvegicus	0-3
26066075-2	2015	However, the MR is also expressed in a range of tissues in which its role appears unrelated to sodium transport, and under normal physiological conditions, it may be responding to cortisol (corticosterone in rodents) rather than aldosterone.	Corticosterone	190-204	nuclear receptor subfamily 3, group C, member 2	Mus musculus	13-15
25833129-4	2015	We find no effects on baseline anxiety and depression-related behavior; however, we find that increasing adult neurogenesis is sufficient to reduce anxiety and depression-related behaviors in mice treated chronically with corticosterone (CORT), a mouse model of stress.	Corticosterone	222-236	cortistatin	Mus musculus	238-242
26043694-3	2015	Recently, we reported that stressed mice with elevated plasma corticosterone levels show upregulation and activation of serum glucocorticoid-regulated kinase (Sgk1) in oligodendrocytes.	Corticosterone	62-76	serum/glucocorticoid regulated kinase 1	Mus musculus	159-163
25447645-6	2015	CRH caused an elevation of both body temperature and plasma corticosterone level, while Crh-antisense caused an opposite response.	Corticosterone	60-74	corticotropin releasing hormone	Homo sapiens	0-3
25691152-5	2015	injection of NPW elevates plasma corticosterone levels, the intravenous administration of NPW in conjunction with a corticotropin-releasing hormone (CRH) antagonist blocks NPW-induced corticosterone secretion.	Corticosterone	184-198	corticotropin releasing hormone	Mus musculus	116-147
26034071-1	2015	The corticosterone (CORT) level changes along the circadian rhythm.	Corticosterone	4-18	cortistatin	Rattus norvegicus	20-24
25691152-5	2015	injection of NPW elevates plasma corticosterone levels, the intravenous administration of NPW in conjunction with a corticotropin-releasing hormone (CRH) antagonist blocks NPW-induced corticosterone secretion.	Corticosterone	184-198	corticotropin releasing hormone	Mus musculus	149-152
26037418-4	2015	The experiments in this manuscript sought to determine if pharmacological stimulation of HIF-1alpha via administration of dimethyloxalylglycine (DMOG) would facilitate the corticosterone response to a mild acute stressor.	Corticosterone	172-186	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
26037418-7	2015	At this same two-hour time point, hippocampal expression of FKBP5, an anti-translocation co-chaperone of the glucocorticoid receptor, in the DMOG-treated group was also positively correlated with plasma corticosterone levels.	Corticosterone	203-217	FKBP prolyl isomerase 5	Homo sapiens	60-65
26037418-7	2015	At this same two-hour time point, hippocampal expression of FKBP5, an anti-translocation co-chaperone of the glucocorticoid receptor, in the DMOG-treated group was also positively correlated with plasma corticosterone levels.	Corticosterone	203-217	nuclear receptor subfamily 3 group C member 1	Homo sapiens	109-132
26138544-1	2015	BACKGROUND: Repeated injection of corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depression.	Corticosterone	34-48	cortistatin	Rattus norvegicus	50-54
26904172-7	2015	RESULTS: In the first experiment, we observed that administration of corticosterone (CORT, 0.3, 1 and 3 mg/kg) following memory reactivation impaired subsequent expression of memory in a dose-dependent manner.	Corticosterone	69-83	cortistatin	Mus musculus	85-89
26190975-8	2015	We also found that corticosterone alone enhanced neurosteroid immunostaining in CA1 pyramidal neurons and that this immunostaining was further augmented by 20 mM ethanol.	Corticosterone	19-33	carbonic anhydrase 1	Rattus norvegicus	80-83
26122290-8	2015	This study demonstrated that ACTH administration increased serum corticosterone levels, KYN, 5-HIAA levels, IDO activity (hippocampus), immobility in the forced swimming test (FST) and the latency to feed in the novelty suppressed feeding test (NSFT).	Corticosterone	65-79	pro-opiomelanocortin-alpha	Mus musculus	29-33
25681757-2	2015	This hypothesis is based on previous work showing that depression-like behavior in rats treated with protracted corticosterone develops in concert with decreased dendritic complexity in newborn hippocampal granule neurons and decreased reelin expression in the proliferative subgranular zone of the dentate gyrus.	Corticosterone	112-126	reelin	Rattus norvegicus	236-242
25681757-3	2015	In addition, heterozygous reeler mice with approximately 50% of normal brain levels of reelin are more vulnerable to the depressogenic effects of corticosterone than wild-type mice.	Corticosterone	146-160	reelin	Mus musculus	87-93
25681757-7	2015	We found that corticosterone increases depression-like behavior, decreases the number of reelin+cells in the subgranular zone, and decreases the number and complexity of immature neurons in the granule cell layer.	Corticosterone	14-28	reelin	Rattus norvegicus	89-95
25933105-6	2015	The inactivation of the Gata6 gene alone (Sf1Cre;Gata6(flox/flox)) drastically reduced the adrenal size and corticosterone production in the adult animals.	Corticosterone	108-122	GATA binding protein 6	Mus musculus	24-29
25933105-6	2015	The inactivation of the Gata6 gene alone (Sf1Cre;Gata6(flox/flox)) drastically reduced the adrenal size and corticosterone production in the adult animals.	Corticosterone	108-122	GATA binding protein 6	Mus musculus	49-54
26122290-11	2015	It is suggested that the main target of NPY is the modulation of corticosterone and neuronal plasticity protein levels, which may be closely linked with pharmacological action in a model of tricyclic antidepressant treatment-resistant depression.	Corticosterone	65-79	neuropeptide Y	Mus musculus	40-43
26193673-3	2015	Stress-associated glucocorticoid (corticosterone in rodents and birds; CORT) levels are known to correlate with dominance rank in diverse taxa and to covary with various social factors, such as sex and dominance maintenance styles.	Corticosterone	34-48	cortistatin	Homo sapiens	71-75
25869615-4	2015	Central nesfatin-1 administration elevates circulating ACTH and corticosterone levels.	Corticosterone	64-78	nucleobindin 2	Homo sapiens	8-18
26168952-3	2015	We measured serum corticosterone (CORT) levels at the end of the exposure and periodically registered body weight gain.	Corticosterone	18-32	cortistatin	Rattus norvegicus	34-38
26480650-4	2015	In vitro: the level of active Caspase-3 in NG108-15 cells (neuroblastoma and glioma cell line) after treated with corticosterone (10(-7) mol/L) was detected with Western blot.	Corticosterone	114-128	caspase 3	Mus musculus	30-39
26480650-7	2015	NG108-15 cells could express GABA(B1) receptor endogenously, and the expression of active Caspase-3 increased after corticosterone treatment (P &lt; 0.05).	Corticosterone	116-130	caspase 3	Mus musculus	90-99
26480650-8	2015	In NG108-15 cells transfected with GABA(B2) receptor subunits, baclofen could reduce the effect of corticosterone- induced active Caspase-3 upexpression, while CGP35348 enhanced this effect (P &lt; 0.05).	Corticosterone	99-113	caspase 3	Mus musculus	130-139
25865680-7	2015	Moreover, Gongjin-Dan considerably normalized the forced running stress-induced changes in serum corticosterone and adrenaline levels, as well as brain serotonin level.	Corticosterone	97-111	NBL1, DAN family BMP antagonist	Mus musculus	18-21
26039990-11	2015	In contrast, Nr5a1-driven Tspo cKO mice lost their ability to form corticosterone in response to adrenocorticotropic hormone (ACTH).	Corticosterone	67-81	nuclear receptor subfamily 5, group A, member 1	Mus musculus	13-18
26039990-11	2015	In contrast, Nr5a1-driven Tspo cKO mice lost their ability to form corticosterone in response to adrenocorticotropic hormone (ACTH).	Corticosterone	67-81	translocator protein	Mus musculus	26-30
26039990-11	2015	In contrast, Nr5a1-driven Tspo cKO mice lost their ability to form corticosterone in response to adrenocorticotropic hormone (ACTH).	Corticosterone	67-81	pro-opiomelanocortin-alpha	Mus musculus	97-124
26039990-11	2015	In contrast, Nr5a1-driven Tspo cKO mice lost their ability to form corticosterone in response to adrenocorticotropic hormone (ACTH).	Corticosterone	67-81	pro-opiomelanocortin-alpha	Mus musculus	126-130
25564339-4	2015	Acute corticosterone (1 muM) impaired LTP in the acute hippocampal slices, and this impairment was blocked by RU486, a glucocorticoid receptor (GR) antagonist.	Corticosterone	6-20	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	119-142
25564339-4	2015	Acute corticosterone (1 muM) impaired LTP in the acute hippocampal slices, and this impairment was blocked by RU486, a glucocorticoid receptor (GR) antagonist.	Corticosterone	6-20	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	144-146
25564339-6	2015	Moreover, the hippocampal BDNF level was also significantly reduced in the corticosterone- or long-term stress-treated hippocampus and restored by RU486 co-treatment.	Corticosterone	75-89	brain-derived neurotrophic factor	Rattus norvegicus	26-30
25564339-7	2015	These results suggest that corticosterone and long-term stress induce aberrant synaptic plasticity, memory impairment, and reduction in the hippocampal BDNF level through GR activation.	Corticosterone	27-41	brain-derived neurotrophic factor	Rattus norvegicus	152-156
25564339-7	2015	These results suggest that corticosterone and long-term stress induce aberrant synaptic plasticity, memory impairment, and reduction in the hippocampal BDNF level through GR activation.	Corticosterone	27-41	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	171-173
25744413-5	2015	In contrast, administration of the NO donor sodium nitroprusside (SNP) led to mitochondrial oxidative stress and dysfunction in adrenal glands, which resulted in a blunted corticosterone response to ACTH.	Corticosterone	172-186	proopiomelanocortin	Homo sapiens	199-203
25552599-4	2015	Corticosterone markedly increased the levels of circulating PAI-1 and the PAI-1 mRNA level in the white adipose tissue of wild-type mice.	Corticosterone	0-14	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	60-65
25552599-4	2015	Corticosterone markedly increased the levels of circulating PAI-1 and the PAI-1 mRNA level in the white adipose tissue of wild-type mice.	Corticosterone	0-14	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	74-79
25880747-6	2015	Conversely, there was completely opposite effect at 10(-10) M. In addition, the expression of PTHrP was significantly downregulated at 10(-6) M and 10(-8) M, and was upregulated at 10(-10) M. CONCLUSIONS: The results suggested that corticosterone regulated chicken chondrocytes performance depending on its concentration with high concentrations inhibiting the viability and differentiation of chondrocytes and light concentrations promoting them, and these roles of corticosterone may be in part mediated through PTHrP.	Corticosterone	467-481	parathyroid hormone like hormone	Gallus gallus	94-99
25753028-3	2015	Prior exposure to the anti-inflammatory glucocorticoid, corticosterone (CORT), at levels associated with high physiological stress, can paradoxically prime the CNS to produce a robust proinflammatory response to neurotoxicants and systemic inflammation; such neuroinflammatory effects can be associated with sickness behavior.	Corticosterone	56-70	cortistatin	Mus musculus	72-76
25656477-1	2015	Previously we demonstrated that exposure of the central nucleus of the amygdala (CeA) to elevated corticosterone (CORT) induces nociceptive behaviors that are reversed by glucocorticoid and/or mineralocorticoid (GR/MR) receptor antagonism.	Corticosterone	98-112	carcinoembryonic antigen gene family 4	Rattus norvegicus	81-84
25656477-1	2015	Previously we demonstrated that exposure of the central nucleus of the amygdala (CeA) to elevated corticosterone (CORT) induces nociceptive behaviors that are reversed by glucocorticoid and/or mineralocorticoid (GR/MR) receptor antagonism.	Corticosterone	114-118	carcinoembryonic antigen gene family 4	Rattus norvegicus	81-84
25656477-3	2015	Micropellets of CHOL or CORT were stereotaxically placed on the dorsal margin of the CeA.	Corticosterone	24-28	carcinoembryonic antigen gene family 4	Rattus norvegicus	85-88
25818040-4	2015	In the present study, systemic corticosterone (CORT; 25mg/kg) administration 1h after fear conditioning did not impair the consolidation process but significantly suppressed the return of fear evoked by a subthreshold conditioning (SC) procedure and elevated platform (EP) stress.	Corticosterone	31-45	cortistatin	Rattus norvegicus	47-51
26056061-10	2015	GILZ mRNA expression in adipose tissue displayed a robust circadian rhythm that was entrained with the circadian oscillation of endogenous corticosterone; and is strongly enhanced by acute and chronic dosing.	Corticosterone	139-153	TSC22 domain family, member 3	Rattus norvegicus	0-4
25715988-2	2015	We administered corticosterone (CORT; 33 mug kg(-1) h(-1)) to pregnant mice for 60 h from embryonic day (E) 12.5.	Corticosterone	16-30	cortistatin	Mus musculus	32-36
26029067-5	2015	The Quick Learner subgroup exhibited a transient loss of motivation and the habituation of serum corticosterone (CORT) response to repeated stress.	Corticosterone	97-111	cortistatin	Rattus norvegicus	113-117
25698616-8	2015	Of note is that CeA lesions, but not chemical stimulation, significantly affected HPA axis activation, as indicated by measurements of circulating corticosterone.	Corticosterone	147-161	carcinoembryonic antigen gene family 4	Rattus norvegicus	16-19
25709101-5	2015	The results of this study reveal that GD7 PAE in mice causes HPA axis dysfunction, with males and females showing elevated corticosterone (CORT) and adrenocorticotropic hormone (ACTH) levels, respectively, following a 15-min restraint stress exposure.	Corticosterone	123-137	cortistatin	Mus musculus	139-143
25698598-4	2015	CRTH2-deficient (CRTH2(-/-)) mice showed antidepressant-like activity in a chronic corticosterone treatment-induced depression.	Corticosterone	83-97	prostaglandin D2 receptor 2	Mus musculus	0-5
25698598-4	2015	CRTH2-deficient (CRTH2(-/-)) mice showed antidepressant-like activity in a chronic corticosterone treatment-induced depression.	Corticosterone	83-97	prostaglandin D2 receptor 2	Mus musculus	17-22
25698598-5	2015	Consistent with this observation, the pharmacological inhibition of CRTH2 via the clinically available drug ramatroban also rescued abnormal social interaction and depression-related behavior in well-established models, including chronic corticosterone-, lipopolysaccharide-, and tumor-induced pathologically relevant depression models.	Corticosterone	238-252	prostaglandin D2 receptor 2	Mus musculus	68-73
25698598-6	2015	Importantly, chronic stress via corticosterone treatment increased mRNA levels in PGD2-producing enzymes, such as cyclooxygenase-2 and lipocalin-type PGD2 synthase, in the brain.	Corticosterone	32-46	prostaglandin D2 synthase (brain)	Mus musculus	82-86
25698598-6	2015	Importantly, chronic stress via corticosterone treatment increased mRNA levels in PGD2-producing enzymes, such as cyclooxygenase-2 and lipocalin-type PGD2 synthase, in the brain.	Corticosterone	32-46	prostaglandin-endoperoxide synthase 2	Mus musculus	114-130
25698598-6	2015	Importantly, chronic stress via corticosterone treatment increased mRNA levels in PGD2-producing enzymes, such as cyclooxygenase-2 and lipocalin-type PGD2 synthase, in the brain.	Corticosterone	32-46	prostaglandin D2 synthase (brain)	Mus musculus	150-154
25739654-2	2015	In man, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) generates the active GC cortisol from cortisone (or corticosterone from 11-dehydrocorticosterone in rodents).	Corticosterone	128-142	RNA, U1 small nuclear 1	Homo sapiens	19-74
25849310-10	2015	However, birds with higher corticosterone had higher testicular GnIH expression and lower testosterone.	Corticosterone	27-41	pro-FMRFamide-related neuropeptide VF	Taeniopygia guttata	64-68
25336169-3	2015	Herein, we report that, compared with SR-BI(+/+) counterparts, SR-BI(-/-) mice suffer markedly increased mortality during bacterial pneumonia associated with higher bacterial burden in the lung and blood, deficient induction of the stress glucocorticoid corticosterone, higher serum cytokines, and increased organ injury.	Corticosterone	254-268	scavenger receptor class B, member 1	Mus musculus	63-68
25336169-6	2015	Corticosterone replacement normalized alveolar neutrophilia but not alveolar cytokines, bacterial burden, or mortality, suggesting that adrenal insufficiency derepresses PMN trafficking to the SR-BI(-/-) airway in a cytokine-independent manner.	Corticosterone	0-14	scavenger receptor class B, member 1	Mus musculus	193-198
25731748-3	2015	Here, we report that, in response to acute stress, mice lacking FMRP show a faster elevation of corticosterone and a more immediate impairment in N-methyl-d-aspartate receptor (NMDAR) dependent long-term potentiation (LTP) in the dentate gyrus (DG).	Corticosterone	96-110	fragile X messenger ribonucleoprotein 1	Mus musculus	64-68
25916467-5	2015	injection of FGF19 or FGF1 leads to a ~60% reduction in hepatic glucose production, hepatic acetyl CoA content and whole-body lipolysis, which results from decreases in plasma ACTH and corticosterone concentrations.	Corticosterone	185-199	fibroblast growth factor 19	Rattus norvegicus	13-18
25916467-5	2015	injection of FGF19 or FGF1 leads to a ~60% reduction in hepatic glucose production, hepatic acetyl CoA content and whole-body lipolysis, which results from decreases in plasma ACTH and corticosterone concentrations.	Corticosterone	185-199	fibroblast growth factor 1	Rattus norvegicus	13-17
25880747-6	2015	Conversely, there was completely opposite effect at 10(-10) M. In addition, the expression of PTHrP was significantly downregulated at 10(-6) M and 10(-8) M, and was upregulated at 10(-10) M. CONCLUSIONS: The results suggested that corticosterone regulated chicken chondrocytes performance depending on its concentration with high concentrations inhibiting the viability and differentiation of chondrocytes and light concentrations promoting them, and these roles of corticosterone may be in part mediated through PTHrP.	Corticosterone	232-246	parathyroid hormone like hormone	Gallus gallus	94-99
25421094-4	2015	In this study, serum corticosterone (CORT), a hormone which played a crucial role in immune suppression, was found to be significantly increased in Per2(m/m) mice compared with the one in wild-type mice following LPS administration at ZT3 and ZT8.	Corticosterone	21-35	cortistatin	Mus musculus	37-41
26084225-15	2015	A parallel strong increase of plasma ACTH and corticosterone levels were significantly impaired by IL-1Ra suggesting a marked involvement of stress-induced stimulation of ACTH and corticosterone by IL-1beta in single restraint.	Corticosterone	46-60	interleukin 1 beta	Rattus norvegicus	198-206
26084225-15	2015	A parallel strong increase of plasma ACTH and corticosterone levels were significantly impaired by IL-1Ra suggesting a marked involvement of stress-induced stimulation of ACTH and corticosterone by IL-1beta in single restraint.	Corticosterone	180-194	interleukin 1 receptor antagonist	Rattus norvegicus	99-105
26084225-15	2015	A parallel strong increase of plasma ACTH and corticosterone levels were significantly impaired by IL-1Ra suggesting a marked involvement of stress-induced stimulation of ACTH and corticosterone by IL-1beta in single restraint.	Corticosterone	180-194	interleukin 1 beta	Rattus norvegicus	198-206
26084225-23	2015	Increased plasma IL-1beta level by a single restraint stress is significantly involved in ACTH and corticosterone secretion.	Corticosterone	99-113	interleukin 1 beta	Rattus norvegicus	17-25
25421094-4	2015	In this study, serum corticosterone (CORT), a hormone which played a crucial role in immune suppression, was found to be significantly increased in Per2(m/m) mice compared with the one in wild-type mice following LPS administration at ZT3 and ZT8.	Corticosterone	21-35	period circadian clock 2	Mus musculus	148-152
25421094-4	2015	In this study, serum corticosterone (CORT), a hormone which played a crucial role in immune suppression, was found to be significantly increased in Per2(m/m) mice compared with the one in wild-type mice following LPS administration at ZT3 and ZT8.	Corticosterone	21-35	zinc finger protein 62	Mus musculus	235-238
25601008-3	2015	Given that glucocorticoids can function as anti-inflammatories, are known to increase with EtOH exposure, and influence neurotoxicity, we hypothesized that males and females may exhibit an altered corticosterone (CORT) response following chronic intoxication.	Corticosterone	197-211	cortistatin	Homo sapiens	213-217
25754523-4	2015	We chronically administered the stress hormone corticosterone (CORT), which induces anxiety/depressive-like behavior and normally increases plasma insulin levels, via the drinking water for 10 weeks, and we examined the stress response in KO mice.	Corticosterone	47-61	cortistatin	Mus musculus	63-67
25595975-1	2015	Chronic exposure to the stress hormone corticosterone (CORT) is known to alter plasticity within hippocampal and amygdalar circuits that mediate fear learning and memory.	Corticosterone	39-53	cortistatin	Rattus norvegicus	55-59
25598416-8	2015	If this is correct, then 1) the observed effects of OTR antagonism may reflect alterations in corticosterone feedback to the brain rather than centrally mediated OTR effects, and 2) the negative correlation between OT-Fos colocalization and aggression may reflect the fact that more aggressive, stress hyporesponsive males require less inhibition of the hypothalamo-pituitary-adrenal axis than do less aggressive males, despite the requirement of that inhibition for the normal display of aggression.	Corticosterone	94-108	oxytocin receptor	Homo sapiens	52-55
25551181-0	2015	Somatostatin is essential for the sexual dimorphism of GH secretion, corticosteroid-binding globulin production, and corticosterone levels in mice.	Corticosterone	117-131	somatostatin	Mus musculus	0-12
25754825-6	2015	Consistently, corticosterone decreased palmitoylation of LMO4 and its inhibition of PTP1B in neuronal cells.	Corticosterone	14-28	LIM domain only 4	Mus musculus	57-61
25754825-6	2015	Consistently, corticosterone decreased palmitoylation of LMO4 and its inhibition of PTP1B in neuronal cells.	Corticosterone	14-28	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	84-89
25754825-7	2015	Collectively, these data reveal a stress-responsive corticosterone-LMO4-PTP1B-mGluR5 cascade that impairs amygdalar eCB signaling and contributes to the development of anxiety.	Corticosterone	52-66	LIM domain only 4	Mus musculus	67-71
25754825-7	2015	Collectively, these data reveal a stress-responsive corticosterone-LMO4-PTP1B-mGluR5 cascade that impairs amygdalar eCB signaling and contributes to the development of anxiety.	Corticosterone	52-66	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	72-77
25754825-7	2015	Collectively, these data reveal a stress-responsive corticosterone-LMO4-PTP1B-mGluR5 cascade that impairs amygdalar eCB signaling and contributes to the development of anxiety.	Corticosterone	52-66	glutamate receptor, ionotropic, kainate 1	Mus musculus	78-84
25614240-2	2015	We previously showed greater increases in intra-hippocampal corticosterone (CORT) levels upon Y-maze testing in aged wild-type than in 11beta-HSD1(-/-) mice coinciding with impaired and intact spatial memory, respectively.	Corticosterone	60-74	cortistatin	Mus musculus	76-80
25551181-8	2015	Increased CBG was associated with elevated diurnal peak plasma corticosterone in unstressed WT females and both sexes of Sst-KO mice compared with WT males.	Corticosterone	63-77	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	10-13
25559333-6	2015	These elevated hippocampal corticosterone levels were associated with increased hippocampal 11beta-hydroxysteroid dehydrogenase type 1 protein expression, the enzyme that catalyzes glucocorticoid formation and greater hippocampal glucocorticoid receptor (GR) activation.	Corticosterone	27-41	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	92-134
25269789-4	2015	Male Sprague Dawley rats received either 40 mg/kg corticosterone (CORT) or vehicle for 18 days prior to behavioral testing.	Corticosterone	50-64	cortistatin	Rattus norvegicus	66-70
25189177-10	2015	Restoring physiological circulating corticosterone levels abrogated molecular changes in adipocytes and the favorable phenotype of Crhr1(-/-) mice.	Corticosterone	36-50	corticotropin releasing hormone receptor 1	Mus musculus	131-136
25189177-13	2015	Circulating corticosterone represses CRF2 activity in adipocytes and may thus regulate adipocyte physiology through the modulation of the local CRF/urocortin system.	Corticosterone	12-26	urocortin	Mus musculus	148-157
25625347-4	2015	In maternal liver, there was no change in glycogen content or glucose 6-phosphatase activity but increased Slc2a2 glucose transporter expression in corticosterone-treated mice, on D16 only (P &lt; 0.05).	Corticosterone	148-162	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	107-113
25625347-7	2015	Depending upon gestational age, corticosterone treatment increased phosphorylation of the insulin-signalling proteins, protein kinase B (Akt) and glycogen synthase-kinase 3beta, in maternal liver (P &lt; 0.05) but not placenta (P &gt; 0.05).	Corticosterone	32-46	thymoma viral proto-oncogene 1	Mus musculus	137-140
25625347-7	2015	Depending upon gestational age, corticosterone treatment increased phosphorylation of the insulin-signalling proteins, protein kinase B (Akt) and glycogen synthase-kinase 3beta, in maternal liver (P &lt; 0.05) but not placenta (P &gt; 0.05).	Corticosterone	32-46	glycogen synthase kinase 3 beta	Mus musculus	146-176
25625347-9	2015	Corticosterone upregulated the stress-inducible mechanistic target of rapamycin (mTOR) suppressor, Redd1, in liver (D16 and D19) and placenta (D19), in ad libitum fed animals (P &lt; 0.05).	Corticosterone	0-14	mechanistic target of rapamycin kinase	Mus musculus	48-79
25625347-9	2015	Corticosterone upregulated the stress-inducible mechanistic target of rapamycin (mTOR) suppressor, Redd1, in liver (D16 and D19) and placenta (D19), in ad libitum fed animals (P &lt; 0.05).	Corticosterone	0-14	mechanistic target of rapamycin kinase	Mus musculus	81-85
25625347-9	2015	Corticosterone upregulated the stress-inducible mechanistic target of rapamycin (mTOR) suppressor, Redd1, in liver (D16 and D19) and placenta (D19), in ad libitum fed animals (P &lt; 0.05).	Corticosterone	0-14	DNA-damage-inducible transcript 4	Mus musculus	99-104
25560830-7	2015	Corticosterone treatment of cultured embryonic pituitary cells increased ERK1/2 activity in an apparent cyclical manner, with a rapid increase within 5 minutes, followed by a reduction to near-basal levels at 3 hours, and a subsequent increase again at 6 hours.	Corticosterone	0-14	mitogen activated protein kinase 3	Rattus norvegicus	73-79
25559333-6	2015	These elevated hippocampal corticosterone levels were associated with increased hippocampal 11beta-hydroxysteroid dehydrogenase type 1 protein expression, the enzyme that catalyzes glucocorticoid formation and greater hippocampal glucocorticoid receptor (GR) activation.	Corticosterone	27-41	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	230-253
25559333-6	2015	These elevated hippocampal corticosterone levels were associated with increased hippocampal 11beta-hydroxysteroid dehydrogenase type 1 protein expression, the enzyme that catalyzes glucocorticoid formation and greater hippocampal glucocorticoid receptor (GR) activation.	Corticosterone	27-41	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	255-257
25496979-11	2015	MLP in pregnancy reduced F1 male and F2 female corticosterone.	Corticosterone	47-61	MARCKS-like 1	Rattus norvegicus	0-3
26038707-1	2015	We characterized mice administered corticosterone (CORT) at a dose of 20 mg/kg for 3 weeks to determine their suitability as a model of mood disorders and found that the time immobilized in the tail suspension test was longer and the time spent in the open arms of the elevated plus-maze test was shorter than those of the vehicle-treated group, findings demonstrating that chronic CORT induced both depression-like and anxiety-like behaviors.	Corticosterone	35-49	cortistatin	Mus musculus	51-55
26038707-1	2015	We characterized mice administered corticosterone (CORT) at a dose of 20 mg/kg for 3 weeks to determine their suitability as a model of mood disorders and found that the time immobilized in the tail suspension test was longer and the time spent in the open arms of the elevated plus-maze test was shorter than those of the vehicle-treated group, findings demonstrating that chronic CORT induced both depression-like and anxiety-like behaviors.	Corticosterone	35-49	cortistatin	Mus musculus	382-386
25268050-0	2015	Corticosterone mediates the inhibitory effect of restraint stress on the migration of mesenchymal stem cell to carbon tetrachloride-induced fibrotic liver by downregulating CXCR4/7 expression.	Corticosterone	0-14	chemokine (C-X-C motif) receptor 4	Mus musculus	173-178
25268050-11	2015	Culture with the serum of CCl4-treated mice or SDF-1 promoted MSC migration, which was suppressed by corticosterone.	Corticosterone	101-115	chemokine (C-C motif) ligand 4	Mus musculus	26-30
25268050-11	2015	Culture with the serum of CCl4-treated mice or SDF-1 promoted MSC migration, which was suppressed by corticosterone.	Corticosterone	101-115	chemokine (C-X-C motif) ligand 12	Mus musculus	47-52
25268050-12	2015	Exposure of MSCs to corticosterone decreased their expression of C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7).	Corticosterone	20-34	chemokine (C-X-C motif) receptor 4	Mus musculus	65-96
25268050-12	2015	Exposure of MSCs to corticosterone decreased their expression of C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7).	Corticosterone	20-34	chemokine (C-X-C motif) receptor 4	Mus musculus	98-103
25268050-12	2015	Exposure of MSCs to corticosterone decreased their expression of C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7).	Corticosterone	20-34	atypical chemokine receptor 3	Mus musculus	109-140
25268050-12	2015	Exposure of MSCs to corticosterone decreased their expression of C-X-C chemokine receptor type 4 (CXCR4) and C-X-C chemokine receptor type 7 (CXCR7).	Corticosterone	20-34	atypical chemokine receptor 3	Mus musculus	142-147
25268050-13	2015	These results demonstrate that the inhibitory effect of corticosterone on MSC migration might be mediated via decreasing the expression of CXCR4 and CXCR7 in MSCs.	Corticosterone	56-70	chemokine (C-X-C motif) receptor 4	Mus musculus	139-144
25600109-2	2015	Here we show that mice lacking SST (Sst(KO)) exhibit elevated behavioral emotionality, high basal plasma corticosterone and reduced gene expression of Bdnf, Cortistatin and Gad67, together recapitulating behavioral, neuroendocrine and molecular features of human depression.	Corticosterone	105-119	somatostatin	Mus musculus	36-43
25268050-13	2015	These results demonstrate that the inhibitory effect of corticosterone on MSC migration might be mediated via decreasing the expression of CXCR4 and CXCR7 in MSCs.	Corticosterone	56-70	atypical chemokine receptor 3	Mus musculus	149-154
25695914-3	2015	Here using optogenetic approaches in mice, we show that neurons that produce hypocretin (Hcrt)/orexin in the lateral hypothalamic area (LHA) regulate corticosterone release and a variety of behaviours and physiological hallmarks of the stress response.	Corticosterone	150-164	hypocretin	Mus musculus	89-93
25695914-3	2015	Here using optogenetic approaches in mice, we show that neurons that produce hypocretin (Hcrt)/orexin in the lateral hypothalamic area (LHA) regulate corticosterone release and a variety of behaviours and physiological hallmarks of the stress response.	Corticosterone	150-164	hypocretin	Mus musculus	95-101
25692682-4	2015	In a second series of experiments, we examined how maternal administration of the glucocorticoids corticosterone and dexamethasone between embryonic days 12.5-15 affected TRPM6 and TRPM7 channel mRNA expression in the mother and fetus.	Corticosterone	98-112	transient receptor potential cation channel, subfamily M, member 6	Mus musculus	171-176
25692682-4	2015	In a second series of experiments, we examined how maternal administration of the glucocorticoids corticosterone and dexamethasone between embryonic days 12.5-15 affected TRPM6 and TRPM7 channel mRNA expression in the mother and fetus.	Corticosterone	98-112	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	181-186
25328143-6	2015	The levels of corticosterone in plasma were similar between WT and OPN(-/-) sham animals but they increased 24 h after CLP induction in the WT mice, but not in the OPN(-/-) mice.	Corticosterone	14-28	secreted phosphoprotein 1	Mus musculus	67-70
25427854-1	2015	Corticosterone (CORT) is a glucocorticoid produced by adrenal glands under the control of the hypothalamic-pituitary-adrenal axis.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
25469828-0	2015	GLP-1 receptor agonists have a sustained stimulatory effect on corticosterone release after chronic treatment.	Corticosterone	63-77	glucagon-like peptide 1 receptor	Mus musculus	0-14
25469828-8	2015	Both of the GLP-1 receptor agonists induced robust increases in corticosterone levels in mice under basal conditions as well as in the case of combination with swimming stress.	Corticosterone	64-78	glucagon-like peptide 1 receptor	Mus musculus	12-26
25257108-8	2015	The behavioral impairments in Rag2(-/-) mice were paralleled by an elevation in plasma corticosterone after behavioral tests.	Corticosterone	87-101	recombination activating gene 2	Mus musculus	30-34
25447936-7	2015	The effect of corticosterone on CSD frequency was normalised by pre-administration of the glucocorticoid receptor (GR) antagonist mifepristone.	Corticosterone	14-28	nuclear receptor subfamily 3, group C, member 1	Mus musculus	90-113
25406021-6	2015	At 60 minutes after administration, 800 pmol of RLN3 produced a significant increase in plasma corticosterone and in the expression of CRF and c-fos mRNAs in the parvocellular paraventricular hypothalamic nucleus (PVN) in male but not female rats.	Corticosterone	95-109	relaxin 3	Rattus norvegicus	48-52
25280788-8	2015	Lastly, an acute stress challenge increased corticosterone (CORT) levels in the CBL, suggesting that stress-induced increases in CORT levels may contribute to the neuroanatomical and neurochemical effects of RRS in the CBL.	Corticosterone	44-58	cortistatin	Rattus norvegicus	60-64
25445195-0	2015	Brain-derived neurotrophic factor heterozygous mutant rats show selective cognitive changes and vulnerability to chronic corticosterone treatment.	Corticosterone	121-135	brain-derived neurotrophic factor	Rattus norvegicus	0-33
25446601-13	2015	CONCLUSION: WEG possessed neuroprotection against corticosterone-induced damage in PC12 cells, and the underlying molecule mechanisms was depended on the intervening of HDAC6 and HSP90 of the GR-related function proteins, and subsequent restoration of ER and mitochondria functions.	Corticosterone	50-64	histone deacetylase 6	Rattus norvegicus	169-174
25446601-13	2015	CONCLUSION: WEG possessed neuroprotection against corticosterone-induced damage in PC12 cells, and the underlying molecule mechanisms was depended on the intervening of HDAC6 and HSP90 of the GR-related function proteins, and subsequent restoration of ER and mitochondria functions.	Corticosterone	50-64	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	179-184
25451109-0	2015	Differential effects of corticosterone on the colocalization of reelin and neuronal nitric oxide synthase in the adult hippocampus in wild type and heterozygous reeler mice.	Corticosterone	24-38	reelin	Mus musculus	64-70
25451109-0	2015	Differential effects of corticosterone on the colocalization of reelin and neuronal nitric oxide synthase in the adult hippocampus in wild type and heterozygous reeler mice.	Corticosterone	24-38	nitric oxide synthase 1, neuronal	Mus musculus	75-105
25451109-1	2015	Repeated corticosterone (CORT) treatment induces a deficit in dentate gyrus subgranular zone reelin-positive cells, in maturation of newborn neurons, and results in a consistent depressive-like behavior.	Corticosterone	9-23	cortistatin	Mus musculus	25-29
25451109-1	2015	Repeated corticosterone (CORT) treatment induces a deficit in dentate gyrus subgranular zone reelin-positive cells, in maturation of newborn neurons, and results in a consistent depressive-like behavior.	Corticosterone	9-23	reelin	Mus musculus	93-99
25179821-4	2015	Enhanced glucocorticoid prereceptor metabolism, assessed by elevated intracellular corticosterone and increased 11 beta-hydroxysteroid dehydrogenase type 1 mRNA and protein levels, was accompanied by glucocorticoid receptor (GR) nuclear accumulation.	Corticosterone	83-97	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	225-227
26581387-7	2015	Biochemical studies indicate that basal plasma corticosterone level increased in both PSG and MAMG rats compared to the control group.	Corticosterone	47-61	pregnancy-specific beta 1-glycoprotein	Rattus norvegicus	86-89
26621444-3	2015	Administration of corticosterone (CORT) plus glucose completely recovered the memory deficit caused by ADX, and this effect was better than that of glucose or CORT alone.	Corticosterone	18-32	cortistatin	Rattus norvegicus	34-38
26621444-3	2015	Administration of corticosterone (CORT) plus glucose completely recovered the memory deficit caused by ADX, and this effect was better than that of glucose or CORT alone.	Corticosterone	18-32	cortistatin	Rattus norvegicus	159-163
25495872-3	2015	It was previously shown that FGF21 induces corticosterone levels in mice by acting on the brain.	Corticosterone	43-57	fibroblast growth factor 21	Mus musculus	29-34
25495872-5	2015	FGF21 also increases corticosterone secretion from the adrenal in response to ACTH.	Corticosterone	21-35	fibroblast growth factor 21	Mus musculus	0-5
25576134-4	2015	Pre-retrieval injection of corticosterone (CORT, 1, 3, and 10mg/kg) to OVX rats impaired memory retrieval at all doses tested.	Corticosterone	27-41	cortistatin	Rattus norvegicus	43-47
25447752-6	2015	Our results demonstrate that LPS administration induces anxiety-like behaviour and a significant increase in cytokines and corticosterone levels in maternal serum.	Corticosterone	123-137	toll-like receptor 4	Mus musculus	29-32
25447752-7	2015	However, in male offspring, prenatal LPS administration has no significant effects on serum cytokines and corticosterone secretion with an exception of the lowest LPS dose that slightly reduced corticosterone levels.	Corticosterone	194-208	toll-like receptor 4	Mus musculus	163-166
25638817-3	2015	METHODS: Behavioral, electrophysiological and biochemical approaches were used to characterize the emotional phenotype, serotonergic and noradrenergic electrical activity, and corticosterone in melatonin MT1 receptor knockout mice and their wild type counterparts, during both light and dark phases.	Corticosterone	176-190	metallothionein 1	Mus musculus	204-207
25638817-6	2015	In addition, MT1 receptor knockout mice exhibit psychomotor disturbances, higher serum levels of corticosterone the dark phase, and a blunted circadian variation of corticosterone levels.	Corticosterone	97-111	metallothionein 1	Mus musculus	13-16
25638817-6	2015	In addition, MT1 receptor knockout mice exhibit psychomotor disturbances, higher serum levels of corticosterone the dark phase, and a blunted circadian variation of corticosterone levels.	Corticosterone	165-179	metallothionein 1	Mus musculus	13-16
25528333-1	2015	Aldosterone synthase (CYP11B2) catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.	Corticosterone	67-81	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	0-20
25528333-1	2015	Aldosterone synthase (CYP11B2) catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone.	Corticosterone	67-81	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	22-29
25486591-3	2015	The results demonstrate that chronic restraint stress increased the number of caspase-3 immunoreactive cells in the HR group, whereas repeated corticosterone treatment increased the number of caspase-3 immunoreactive cells in both the HR and LR groups.	Corticosterone	143-157	caspase 3	Rattus norvegicus	192-201
25280788-8	2015	Lastly, an acute stress challenge increased corticosterone (CORT) levels in the CBL, suggesting that stress-induced increases in CORT levels may contribute to the neuroanatomical and neurochemical effects of RRS in the CBL.	Corticosterone	44-58	Cbl proto-oncogene	Rattus norvegicus	80-83
25280788-8	2015	Lastly, an acute stress challenge increased corticosterone (CORT) levels in the CBL, suggesting that stress-induced increases in CORT levels may contribute to the neuroanatomical and neurochemical effects of RRS in the CBL.	Corticosterone	44-58	cortistatin	Rattus norvegicus	129-133
25280788-8	2015	Lastly, an acute stress challenge increased corticosterone (CORT) levels in the CBL, suggesting that stress-induced increases in CORT levels may contribute to the neuroanatomical and neurochemical effects of RRS in the CBL.	Corticosterone	44-58	Cbl proto-oncogene	Rattus norvegicus	219-222
25535367-4	2015	Using a mouse model of excess corticosterone exposure, we found that the ability of glucocorticoids to increase adiposity, weight gain, hormonal dysregulation, hepatic steatosis, and dyslipidemia was reduced or reversed in mice lacking the cannabinoid CB1 receptor as well as mice treated with the global CB1 receptor antagonist AM251.	Corticosterone	30-44	cannabinoid receptor 1 (brain)	Mus musculus	252-255
25535367-4	2015	Using a mouse model of excess corticosterone exposure, we found that the ability of glucocorticoids to increase adiposity, weight gain, hormonal dysregulation, hepatic steatosis, and dyslipidemia was reduced or reversed in mice lacking the cannabinoid CB1 receptor as well as mice treated with the global CB1 receptor antagonist AM251.	Corticosterone	30-44	cannabinoid receptor 1 (brain)	Mus musculus	305-308
25535367-5	2015	Similarly, a neutral, peripherally restricted CB1 receptor antagonist (AM6545) was able to attenuate the metabolic phenotype caused by chronic corticosterone, suggesting a peripheral mechanism for these effects.	Corticosterone	143-157	cannabinoid receptor 1 (brain)	Mus musculus	46-49
25561902-8	2015	ACVR2B:Fc treatment also elevated serum levels of the glucocorticoid corticosterone.	Corticosterone	69-83	activin receptor IIB	Mus musculus	0-6
25430741-5	2015	Pharmacological tools combined with RNA interference demonstrate that secretagogin"s loss of function occludes adrenocorticotropic hormone release from the pituitary and lowers peripheral corticosterone levels in response to acute stress.	Corticosterone	188-202	secretagogin, EF-hand calcium binding protein	Homo sapiens	70-82
25389364-4	2015	We observed that corticosterone (CORT) treatment increased expression of 11beta-HSD1 and H6PDH and induced lipase HSL and ATGL with suppression of p-Thr(172) AMPK in adipose tissue of C57BL/6J mice.	Corticosterone	17-31	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	73-84
25389364-4	2015	We observed that corticosterone (CORT) treatment increased expression of 11beta-HSD1 and H6PDH and induced lipase HSL and ATGL with suppression of p-Thr(172) AMPK in adipose tissue of C57BL/6J mice.	Corticosterone	17-31	lipase, endothelial	Mus musculus	107-113
25389364-4	2015	We observed that corticosterone (CORT) treatment increased expression of 11beta-HSD1 and H6PDH and induced lipase HSL and ATGL with suppression of p-Thr(172) AMPK in adipose tissue of C57BL/6J mice.	Corticosterone	17-31	patatin-like phospholipase domain containing 2	Mus musculus	122-126
25389364-4	2015	We observed that corticosterone (CORT) treatment increased expression of 11beta-HSD1 and H6PDH and induced lipase HSL and ATGL with suppression of p-Thr(172) AMPK in adipose tissue of C57BL/6J mice.	Corticosterone	33-37	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	73-84
25389364-4	2015	We observed that corticosterone (CORT) treatment increased expression of 11beta-HSD1 and H6PDH and induced lipase HSL and ATGL with suppression of p-Thr(172) AMPK in adipose tissue of C57BL/6J mice.	Corticosterone	33-37	lipase, endothelial	Mus musculus	107-113
25389364-4	2015	We observed that corticosterone (CORT) treatment increased expression of 11beta-HSD1 and H6PDH and induced lipase HSL and ATGL with suppression of p-Thr(172) AMPK in adipose tissue of C57BL/6J mice.	Corticosterone	33-37	patatin-like phospholipase domain containing 2	Mus musculus	122-126
25389364-6	2015	Furthermore, 11beta-HSD1 shRNA attenuated CORT-induced 11beta-HSD1 and lipase expression and improved insulin sensitivity with a concomitant stimulation of pThr(308) Akt/PKB and p-Thr(172) AMPK within adipose tissue.	Corticosterone	42-46	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	13-24
25389364-6	2015	Furthermore, 11beta-HSD1 shRNA attenuated CORT-induced 11beta-HSD1 and lipase expression and improved insulin sensitivity with a concomitant stimulation of pThr(308) Akt/PKB and p-Thr(172) AMPK within adipose tissue.	Corticosterone	42-46	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	55-66
25389364-6	2015	Furthermore, 11beta-HSD1 shRNA attenuated CORT-induced 11beta-HSD1 and lipase expression and improved insulin sensitivity with a concomitant stimulation of pThr(308) Akt/PKB and p-Thr(172) AMPK within adipose tissue.	Corticosterone	42-46	lipase, endothelial	Mus musculus	71-77
25389364-6	2015	Furthermore, 11beta-HSD1 shRNA attenuated CORT-induced 11beta-HSD1 and lipase expression and improved insulin sensitivity with a concomitant stimulation of pThr(308) Akt/PKB and p-Thr(172) AMPK within adipose tissue.	Corticosterone	42-46	thymoma viral proto-oncogene 1	Mus musculus	170-173
25394830-0	2015	Renin knockout rat: control of adrenal aldosterone and corticosterone synthesis in vitro and adrenal gene expression.	Corticosterone	55-69	renin	Rattus norvegicus	0-5
25447936-7	2015	The effect of corticosterone on CSD frequency was normalised by pre-administration of the glucocorticoid receptor (GR) antagonist mifepristone.	Corticosterone	14-28	nuclear receptor subfamily 3, group C, member 1	Mus musculus	115-117
25084759-7	2015	In conclusion, agmatine affords neuroprotection against corticosterone effects by a mechanism that implicates Nrf2 induction via alpha2-adrenergic and 5-HT2A receptors, Akt and ERK pathways, and HO-1 and GCLc expression.	Corticosterone	56-70	NFE2 like bZIP transcription factor 2	Homo sapiens	110-114
25084759-7	2015	In conclusion, agmatine affords neuroprotection against corticosterone effects by a mechanism that implicates Nrf2 induction via alpha2-adrenergic and 5-HT2A receptors, Akt and ERK pathways, and HO-1 and GCLc expression.	Corticosterone	56-70	heme oxygenase 1	Homo sapiens	195-199
25447798-2	2015	The main regulator of intracellular glucocorticoid levels is 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which converts inactive glucocorticoids into bioactive forms such as cortisol in humans and corticosterone in rodents.	Corticosterone	211-225	RNA, U1 small nuclear 1	Homo sapiens	61-116
26324338-7	2015	Since the infant amygdala relies on the presence of corticosterone (CORT), this suggests that social buffering of pups by the mother attenuates the neurobehavioral stress response in infancy and prevents pups from learning about threat within mother-infant interactions.	Corticosterone	52-66	cortistatin	Homo sapiens	68-72
25556979-2	2015	We investigated long-term changes in the corticosterone (CORT)-sensitive function of this network following fear conditioning and fear memory reactivation.	Corticosterone	41-55	cortistatin	Mus musculus	57-61
25815975-0	2015	Differential modulation of synaptic plasticity and local circuit activity in the dentate gyrus and CA1 regions of the rat hippocampus by corticosterone.	Corticosterone	137-151	carbonic anhydrase 1	Rattus norvegicus	99-102
25853791-1	2015	Acute restraint stress (ARS) for 3 h causes corticosterone (CORT) elevation in venous blood, which is accompanied by Fos up-regulation in the paraventricular nucleus (PVN) of male C57BL/6 mice.	Corticosterone	44-58	cortistatin	Mus musculus	60-64
26068518-6	2015	Corticosterone radioimmunoassay revealed that the disruptions in PVN GR and CRH expression led to elevated basal corticosterone secretion in male Sim1Cre-GRe3Delta mice by early adolescence and increased stress-induced (restraint) corticosterone secretion in late adolescence into adulthood.	Corticosterone	0-14	corticotropin releasing hormone	Mus musculus	76-79
26068518-6	2015	Corticosterone radioimmunoassay revealed that the disruptions in PVN GR and CRH expression led to elevated basal corticosterone secretion in male Sim1Cre-GRe3Delta mice by early adolescence and increased stress-induced (restraint) corticosterone secretion in late adolescence into adulthood.	Corticosterone	113-127	corticotropin releasing hormone	Mus musculus	76-79
26068518-6	2015	Corticosterone radioimmunoassay revealed that the disruptions in PVN GR and CRH expression led to elevated basal corticosterone secretion in male Sim1Cre-GRe3Delta mice by early adolescence and increased stress-induced (restraint) corticosterone secretion in late adolescence into adulthood.	Corticosterone	231-245	corticotropin releasing hormone	Mus musculus	76-79
25446927-4	2014	The increases in plasma corticosterone were prevented by prior central or peripheral administration of LY426965, a specific 5HT1A antagonist.	Corticosterone	24-38	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	124-129
25244085-8	2014	Unexpectedly, both the lowest licked offspring from low LG litters and the highest licked offspring from high LG litters showed suppressed corticosterone (CORT) responses to stress.	Corticosterone	139-153	cortistatin	Rattus norvegicus	155-159
25314660-3	2014	These experiments compared the short- and long-term effects of exposure to the stress-related hormone corticosterone (CORT) on the extinction of learned fear in adolescent and adult rats.	Corticosterone	102-116	cortistatin	Rattus norvegicus	118-122
25024372-3	2014	Prolonged fasting induces activation of the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) in the liver and subsequent hepatic production of FGF21, which enters into the brain to activate the hypothalamic-pituitary-adrenal (HPA) axis for release of corticosterone, thereby stimulating hepatic gluconeogenesis.	Corticosterone	284-298	peroxisome proliferator activated receptor alpha	Mus musculus	65-113
25024372-3	2014	Prolonged fasting induces activation of the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) in the liver and subsequent hepatic production of FGF21, which enters into the brain to activate the hypothalamic-pituitary-adrenal (HPA) axis for release of corticosterone, thereby stimulating hepatic gluconeogenesis.	Corticosterone	284-298	peroxisome proliferator activated receptor alpha	Mus musculus	115-124
25024372-3	2014	Prolonged fasting induces activation of the transcription factor peroxisome proliferator-activated receptor alpha (PPARalpha) in the liver and subsequent hepatic production of FGF21, which enters into the brain to activate the hypothalamic-pituitary-adrenal (HPA) axis for release of corticosterone, thereby stimulating hepatic gluconeogenesis.	Corticosterone	284-298	fibroblast growth factor 21	Mus musculus	176-181
25024372-4	2014	Fasted FGF21 knockout (KO) mice exhibit severe hypoglycemia and defective hepatic gluconeogenesis due to impaired activation of the HPA axis and blunted release of corticosterone, a phenotype similar to that observed in PPARalpha KO mice.	Corticosterone	164-178	fibroblast growth factor 21	Mus musculus	7-12
25024372-5	2014	By contrast, intracerebroventricular injection of FGF21 reverses fasting hypoglycemia and impairment in hepatic gluconeogenesis by restoring corticosterone production in both FGF21 KO and PPARalpha KO mice, whereas all these central effects of FGF21 were abrogated by blockage of hypothalamic FGF receptor-1.	Corticosterone	141-155	fibroblast growth factor 21	Mus musculus	50-55
25283355-9	2014	injection of corticosterone stimulated pro-TRH expression in the PVN of rats kept at ambient temperature, more pronouncedly in hypophysiotrophic neurones that no longer responded to cold exposure.	Corticosterone	13-27	thyrotropin releasing hormone	Rattus norvegicus	39-46
25283355-10	2014	In corticosterone-pretreated rats, the cold-induced increase in pro-TRH expression was detected only in the rostral PVN.	Corticosterone	3-17	thyrotropin releasing hormone	Rattus norvegicus	64-71
25554981-5	2014	Moreover, the second goal of this study was to find out whether melatonin receptors MT1 and/or MT2 are involved in the regulation of ACTH and corticosterone secretion into the blood.	Corticosterone	142-156	metallothionein 1	Rattus norvegicus	84-87
25554981-5	2014	Moreover, the second goal of this study was to find out whether melatonin receptors MT1 and/or MT2 are involved in the regulation of ACTH and corticosterone secretion into the blood.	Corticosterone	142-156	metallothionein 2A	Rattus norvegicus	95-98
25306460-1	2014	An experiment was conducted to determine the effect of corticosterone (CORT) administration on serum ovotransferrin (OVT), alpha1-acid glycoprotein (AGP), ceruloplasmin (CPN), and IL-6 concentrations, and brain heat shock protein (HSP) 70 expression in broiler chickens.	Corticosterone	71-75	transferrin (ovotransferrin)	Gallus gallus	101-115
24825609-11	2014	Furthermore, TFF3 pretreatment significantly reduced morphine withdrawal-induced increases in plasma corticosterone and adrenocorticotropic hormone levels.	Corticosterone	101-115	trefoil factor 3, intestinal	Mus musculus	13-17
25244639-16	2014	Plasma free corticosterone levels in Cbg k.o.	Corticosterone	12-26	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	37-40
24702258-5	2014	Using a combination of both in vivo and in vitro approaches, we demonstrated that either CBS/CSE inhibitors or small interfering RNAs led to mitochondrial oxidative stress and dysfunction, which meanwhile resulted in blunted corticosterone responses to adrenocorticotropic hormone (ACTH).	Corticosterone	225-239	cystathionine beta-synthase	Homo sapiens	89-92
24702258-5	2014	Using a combination of both in vivo and in vitro approaches, we demonstrated that either CBS/CSE inhibitors or small interfering RNAs led to mitochondrial oxidative stress and dysfunction, which meanwhile resulted in blunted corticosterone responses to adrenocorticotropic hormone (ACTH).	Corticosterone	225-239	cystathionase (cystathionine gamma-lyase)	Mus musculus	93-96
24702258-5	2014	Using a combination of both in vivo and in vitro approaches, we demonstrated that either CBS/CSE inhibitors or small interfering RNAs led to mitochondrial oxidative stress and dysfunction, which meanwhile resulted in blunted corticosterone responses to adrenocorticotropic hormone (ACTH).	Corticosterone	225-239	proopiomelanocortin	Homo sapiens	253-280
25244639-20	2014	The turnover of a corticosterone bolus was increased in Cbg k.o.	Corticosterone	18-32	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	56-59
25393872-7	2014	Cyp51+/- females fed high-fat, high-cholesterol diet were leaner and had elevated plasma corticosterone compared to controls.	Corticosterone	89-103	cytochrome P450, family 51	Mus musculus	0-5
25173821-3	2014	MR binds aldosterone, cortisol and corticosterone with similar affinity, while the glucocorticoid receptor (GR) has less affinity for cortisol and corticosterone.	Corticosterone	147-161	nuclear receptor subfamily 3 group C member 1	Homo sapiens	83-106
25173821-3	2014	MR binds aldosterone, cortisol and corticosterone with similar affinity, while the glucocorticoid receptor (GR) has less affinity for cortisol and corticosterone.	Corticosterone	147-161	nuclear receptor subfamily 3 group C member 1	Homo sapiens	108-110
25173821-7	2014	Where 11beta-hydroxydehydrogenase 2 (11beta-HSD2) that inactivates cortisol and corticosterone in aldosterone target cells of the kidney and nucleus tractus solitarius (NTS) is not expressed, as in most neurons, MR are activated at basal glucocorticoid concentrations, GR at stress concentrations.	Corticosterone	80-94	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	6-48
26074181-7	2015	In vitro study revealed that corticosterone and dexamethasone directly increased UCP2 expression in mouse RAW 264.7 macrophages and suppressed the generation of LPS-induced mitochondrial reactive oxygen species (ROS) and TNF-alpha production.	Corticosterone	29-43	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	81-85
25389775-4	2014	A total of thirty-six 5-week-old male C57BL/6J mice (~20 g) were administrated with 100 microg/ml corticosterone (CORT) or vehicle through drinking water for 4 weeks.	Corticosterone	98-112	cortistatin	Mus musculus	114-118
26074181-7	2015	In vitro study revealed that corticosterone and dexamethasone directly increased UCP2 expression in mouse RAW 264.7 macrophages and suppressed the generation of LPS-induced mitochondrial reactive oxygen species (ROS) and TNF-alpha production.	Corticosterone	29-43	tumor necrosis factor	Mus musculus	221-230
25414695-4	2014	In the presence of the dam, adrenal corticosterone (CORT) secretion was low in both mouse strains.	Corticosterone	36-50	cortistatin	Mus musculus	52-56
25365210-7	2014	5-HT1B KO mice that entrained to a 9.5L:13.5D (short day in a T = 23 h) cycle with activity onsets delayed more than 4 h after light offset exhibited a corticosterone rhythm in phase with activity rhythms but reduced 50% in amplitude compared to animals that initiated daily activity &lt;4 h after light offset.	Corticosterone	152-166	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	0-6
25214399-2	2014	Corticosterone (CORT) levels, which are mainly studied with regard to stress, are also increased during fasting.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
25405735-2	2014	Stress increases the secretion of glucocorticoid (corticosterone, CORT; in rats), which decreases circulating testosterone levels in part through a direct action by binding to the glucocorticoid receptors (NR3C1) in Leydig cells.	Corticosterone	50-64	nuclear receptor subfamily 3, group C, member 1	Mus musculus	206-211
25138046-1	2014	This study determines the effect of atrazine and fenitrothion no-observed-effect-levels (NOEL) on the binding of corticosterone (B) to corticosterone-binding-globulin (CBG) in an amphibian and a mammal.	Corticosterone	113-127	serpin family A member 6	Homo sapiens	135-166
25138046-1	2014	This study determines the effect of atrazine and fenitrothion no-observed-effect-levels (NOEL) on the binding of corticosterone (B) to corticosterone-binding-globulin (CBG) in an amphibian and a mammal.	Corticosterone	113-127	serpin family A member 6	Homo sapiens	168-171
25085924-0	2014	Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone.	Corticosterone	106-120	pro-opiomelanocortin-alpha	Mus musculus	29-56
25085924-0	2014	Direct activating effects of adrenocorticotropic hormone (ACTH) on brown adipose tissue are attenuated by corticosterone.	Corticosterone	106-120	pro-opiomelanocortin-alpha	Mus musculus	58-62
25085924-8	2014	In T37i cells, corticosterone prevented induction of Ucp1 mRNA and Ucp1 protein by both ACTH and norepinephrine in a glucocorticoid receptor (GR)-dependent fashion.	Corticosterone	15-29	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	53-57
25085924-8	2014	In T37i cells, corticosterone prevented induction of Ucp1 mRNA and Ucp1 protein by both ACTH and norepinephrine in a glucocorticoid receptor (GR)-dependent fashion.	Corticosterone	15-29	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	67-71
25085924-8	2014	In T37i cells, corticosterone prevented induction of Ucp1 mRNA and Ucp1 protein by both ACTH and norepinephrine in a glucocorticoid receptor (GR)-dependent fashion.	Corticosterone	15-29	pro-opiomelanocortin-alpha	Mus musculus	88-92
25193253-1	2014	The measure of corticosterone (CORT) in feathers has been recently recognized as a valid and easily obtainable measure of chronic glucocorticoids secretion in avian species.	Corticosterone	15-29	cortistatin	Homo sapiens	31-35
25239533-8	2014	Heat shock protein 90 was positively correlated with corticosterone and superoxide dismutase activities (P &lt; 0.01), and HSP90 mRNA was negatively correlated with pH after chilling for 24 h. The results demonstrated that HSP90 plays a pivotal role in protecting cells from oxidation.	Corticosterone	53-67	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-21
25239533-8	2014	Heat shock protein 90 was positively correlated with corticosterone and superoxide dismutase activities (P &lt; 0.01), and HSP90 mRNA was negatively correlated with pH after chilling for 24 h. The results demonstrated that HSP90 plays a pivotal role in protecting cells from oxidation.	Corticosterone	53-67	heat shock protein 90 alpha family class A member 1	Homo sapiens	223-228
24442851-8	2014	Partial genetic deletion of Nrg1 also modulated the adaptive response of the hypothalamic-pituitary-adrenal axis to repeated stress, with Nrg1 HET displaying a reduced repeated stress-induced level of plasma corticosterone than WT mice.	Corticosterone	208-222	neuregulin 1	Mus musculus	28-32
24442851-8	2014	Partial genetic deletion of Nrg1 also modulated the adaptive response of the hypothalamic-pituitary-adrenal axis to repeated stress, with Nrg1 HET displaying a reduced repeated stress-induced level of plasma corticosterone than WT mice.	Corticosterone	208-222	neuregulin 1	Mus musculus	138-142
25571709-11	2014	And the immoblility time in both HCN1-/- and HCN1+/+ mice was increased after oral administration of low dose corticosterone, with an increase in depression.	Corticosterone	110-124	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	33-37
25571709-11	2014	And the immoblility time in both HCN1-/- and HCN1+/+ mice was increased after oral administration of low dose corticosterone, with an increase in depression.	Corticosterone	110-124	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Mus musculus	45-49
25364551-0	2014	Co-Application of Corticosterone and Growth Hormone Upregulates NR2B Protein and Increases the NR2B:NR2A Ratio and Synaptic Transmission in the Hippocampus.	Corticosterone	18-32	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	64-68
25364551-0	2014	Co-Application of Corticosterone and Growth Hormone Upregulates NR2B Protein and Increases the NR2B:NR2A Ratio and Synaptic Transmission in the Hippocampus.	Corticosterone	18-32	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	95-99
25364551-0	2014	Co-Application of Corticosterone and Growth Hormone Upregulates NR2B Protein and Increases the NR2B:NR2A Ratio and Synaptic Transmission in the Hippocampus.	Corticosterone	18-32	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	100-104
25364551-3	2014	The effects of the co-application of GH and corticosterone (CORT) were tested at different concentrations on the field excitatory postsynaptic potentials (fEPSPs) of the hippocampal slices of rats in two different age groups.	Corticosterone	44-58	cortistatin	Rattus norvegicus	60-64
25352778-4	2014	Specifically, intracerebroventricular transplantation of iPSC-derived neural progenitors that over-expressed BDNF reversed the impact of immune (lipopolysaccharide) and chronic stressor challenges upon subventricular zone adult neurogenesis, and the iPSC-derived neural progenitor cells alone blunted the stressor-induced corticosterone response.	Corticosterone	322-336	brain derived neurotrophic factor	Homo sapiens	109-113
24801750-5	2014	In response to chronic corticosterone exposure, Htr2a(-/-) mice displayed more pronounced anxiodepressive-like phenotype than wild-type mice, as shown by a significant higher "emotionality score" (p&lt;0.01).	Corticosterone	23-37	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	48-53
24535841-3	2014	Mice lacking the anxiolytic factor NPY exhibit more anxious behavior and elevated corticosterone levels.	Corticosterone	82-96	neuropeptide Y	Mus musculus	35-38
25150542-3	2014	In the current studies we examined how early exposure to the stress hormone corticosterone (CORT) affects the maturation of fear extinction in infant rats.	Corticosterone	76-90	cortistatin	Homo sapiens	92-96
24886880-7	2014	Moreover, the leftward shift of the noradrenaline curves promoted by uptake blockers (cocaine and corticosterone) and beta-adrenoceptor antagonist (propranolol) was reduced in the vas deferens of treated group.	Corticosterone	98-112	arginine vasopressin	Rattus norvegicus	180-183
25354917-4	2014	We experimentally increased levels of the avian stress hormone corticosterone (CORT) in nestling zebra finches in a fully balanced design.	Corticosterone	63-77	cortistatin	Homo sapiens	79-83
25014761-7	2014	These findings indicate that cognitive effects of CORT in female rats can be modulated with the plasma levels of estrogens: when the levels of estrogens are low, corticosterone has a negative effect, while when the levels of estrogens are high; the corticosterone has a positive enhancing effect.	Corticosterone	162-176	cortistatin	Rattus norvegicus	50-54
25014761-7	2014	These findings indicate that cognitive effects of CORT in female rats can be modulated with the plasma levels of estrogens: when the levels of estrogens are low, corticosterone has a negative effect, while when the levels of estrogens are high; the corticosterone has a positive enhancing effect.	Corticosterone	249-263	cortistatin	Rattus norvegicus	50-54
25114262-8	2014	Corticosterone treatment 1 h after PSS-exposure prevented anxiety and hyperarousal 7 d later in both sexes, confirming the GR involvement in the PSS behavioral response.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	123-125
25309370-7	2014	Maternally deprived rats exhibited increased plasma corticosterone (CORT) levels which were higher in maternally deprived and stress challenged pups.	Corticosterone	52-66	cortistatin	Rattus norvegicus	68-72
23775489-10	2014	Following acute stress, LPA1-null mice showed increased corticosterone and c-Fos expression in the amygdala.	Corticosterone	56-70	lysophosphatidic acid receptor 1	Mus musculus	24-28
24926824-1	2014	Although progesterone is most commonly regarded in terms of its role in the female estrous cycle, reproductive behavior, and pregnancy, progesterone is also a precursor to corticosterone (CORT) and is released from the adrenal glands of both sexes in response to stress.	Corticosterone	172-186	cortistatin	Rattus norvegicus	188-192
24420787-9	2014	CONCLUSIONS: The results suggest that the 11betaHSD1-mediated elevation of intracellular corticosterone may induce GR downregulation, which may be associated with failure of GR to stimulate lipolysis in fructose-fed female rats.	Corticosterone	89-103	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	42-52
25236887-8	2014	Notably, we observed a strong shift in acute stress coping behavior in the tail suspension test and basal corticosterone levels in different phases of the estrous cycle in female GPER1-KO mice.	Corticosterone	106-120	G protein-coupled estrogen receptor 1	Mus musculus	179-184
24607259-6	2014	Corticosterone administration resulted in an increase in immobility time in the forced swim test (FST) (p &lt; 0.01) and decreases in the expression of brain-derived neurotrophic factor (BDNF) (p &lt; 0.05) and glial fibrillary acidic protein (GFAP) (p &lt; 0.001) in the hippocampus and frontal cortex.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	152-185
24607259-6	2014	Corticosterone administration resulted in an increase in immobility time in the forced swim test (FST) (p &lt; 0.01) and decreases in the expression of brain-derived neurotrophic factor (BDNF) (p &lt; 0.05) and glial fibrillary acidic protein (GFAP) (p &lt; 0.001) in the hippocampus and frontal cortex.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	187-191
24607259-6	2014	Corticosterone administration resulted in an increase in immobility time in the forced swim test (FST) (p &lt; 0.01) and decreases in the expression of brain-derived neurotrophic factor (BDNF) (p &lt; 0.05) and glial fibrillary acidic protein (GFAP) (p &lt; 0.001) in the hippocampus and frontal cortex.	Corticosterone	0-14	glial fibrillary acidic protein	Rattus norvegicus	211-242
24607259-6	2014	Corticosterone administration resulted in an increase in immobility time in the forced swim test (FST) (p &lt; 0.01) and decreases in the expression of brain-derived neurotrophic factor (BDNF) (p &lt; 0.05) and glial fibrillary acidic protein (GFAP) (p &lt; 0.001) in the hippocampus and frontal cortex.	Corticosterone	0-14	glial fibrillary acidic protein	Rattus norvegicus	244-248
25040027-7	2014	For example, although serotonin (5-HT) has a stimulatory effect on the HPA axis in humans and rodents that is mediated by the 5-HT1A receptor, only male rodents respond to 5-HT1A antagonism to show increased corticosterone responses to stress.	Corticosterone	208-222	5-hydroxytryptamine receptor 1A	Homo sapiens	126-132
24565565-0	2014	The selective glucocorticoid receptor modulator CORT108297 restores faulty hippocampal parameters in Wobbler and corticosterone-treated mice.	Corticosterone	113-127	nuclear receptor subfamily 3, group C, member 1	Mus musculus	14-37
24565565-10	2014	In a separate experiment employing control NFR/NFR mice, treatment with corticosterone for 5 days reduced DCX+ neuroblasts and induced astrocyte hypertrophy, whereas treatment with CORT108297 antagonized these effects.	Corticosterone	72-86	doublecortin	Mus musculus	106-109
24825316-9	2014	CORT treatment increased the levels of phosphorylated TrkB in male R6/1 mice only.	Corticosterone	0-4	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	54-58
24909071-5	2014	In addition, the possible mechanism was determined by measuring plasma corticosterone (CORT) as a marker of hypothalamic-pituitary-adrenocortical (HPA)-axis activity and serotonin levels in the discrete brain regions.	Corticosterone	71-85	cortistatin	Mus musculus	87-91
25047002-7	2014	RESULTS: Corticosterone (CS) and deoxycorticosterone (DOC) inhibited androgen-induced conformational change of the AR in the FRET assay.	Corticosterone	9-23	androgen receptor	Homo sapiens	115-117
25047002-7	2014	RESULTS: Corticosterone (CS) and deoxycorticosterone (DOC) inhibited androgen-induced conformational change of the AR in the FRET assay.	Corticosterone	25-27	androgen receptor	Homo sapiens	115-117
25047002-8	2014	CS inhibited AR-dependent transcriptional activity and cell growth at concentrations comparable to those measured in the serum of AA-treated patients.	Corticosterone	0-2	androgen receptor	Homo sapiens	13-15
25047002-11	2014	CS inhibits AR transcriptional activity and PC cell growth at concentrations found in the serum of patients treated with AA.	Corticosterone	0-2	androgen receptor	Homo sapiens	12-14
25001965-6	2014	BNST PACAP signaling stimulated the hypothalamic-pituitary-adrenal (HPA) axis and heightened corticosterone release; further, BNST PACAP(6-38) administration blocked corticosterone release in a sensitized stress model.	Corticosterone	93-107	adenylate cyclase activating polypeptide 1	Homo sapiens	5-10
25001965-6	2014	BNST PACAP signaling stimulated the hypothalamic-pituitary-adrenal (HPA) axis and heightened corticosterone release; further, BNST PACAP(6-38) administration blocked corticosterone release in a sensitized stress model.	Corticosterone	93-107	adenylate cyclase activating polypeptide 1	Homo sapiens	131-136
25001965-6	2014	BNST PACAP signaling stimulated the hypothalamic-pituitary-adrenal (HPA) axis and heightened corticosterone release; further, BNST PACAP(6-38) administration blocked corticosterone release in a sensitized stress model.	Corticosterone	166-180	adenylate cyclase activating polypeptide 1	Homo sapiens	5-10
25001965-6	2014	BNST PACAP signaling stimulated the hypothalamic-pituitary-adrenal (HPA) axis and heightened corticosterone release; further, BNST PACAP(6-38) administration blocked corticosterone release in a sensitized stress model.	Corticosterone	166-180	adenylate cyclase activating polypeptide 1	Homo sapiens	131-136
24997359-6	2014	Prenatal nicotine exposure caused noticeably lower body weights, higher IUGR rates of fetal rats, and elevated maternal and fetal corticosterone (CORT) levels compared to the controls.	Corticosterone	130-144	cortistatin	Rattus norvegicus	146-150
24970756-5	2014	In this study, we characterized the contribution of plasma corticosterone (CORT) to postnatal maturation of spinal phasic and, for the first time, tonic GABAergic inhibitions.	Corticosterone	59-73	cortistatin	Rattus norvegicus	75-79
24681250-4	2014	Following both intraperitoneal and intravenous administration of IL-1beta, mice lacking IL-1R1 in hematopoietic cells showed induced expression of the activity marker c-Fos in the paraventricular hypothalamic nucleus, and increased plasma levels of ACTH and corticosterone.	Corticosterone	258-272	interleukin 1 beta	Mus musculus	65-73
24636912-0	2014	Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway.	Corticosterone	28-42	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	93-95
24636912-0	2014	Saikosaponin D acts against corticosterone-induced apoptosis via regulation of mitochondrial GR translocation and a GR-dependent pathway.	Corticosterone	28-42	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	116-118
24636912-1	2014	Saikosaponin D is an agonist of the glucocorticoid receptor (GR), and our preliminary study showed that it possesses neuroprotective effects in corticosterone-treated PC12 cells.	Corticosterone	144-158	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	61-63
24636912-7	2014	These additional data suggested that Saikosaponin D partially reversed the physiological changes induced by corticosterone by inhibiting the translocation of the GR to the mitochondria, restoring mitochondrial function, down-regulating the expression of pro-apoptotic-related signalling events and up-regulating anti-apoptotic-related signalling events.	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	162-164
24880571-9	2014	Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines.	Corticosterone	12-26	matrix metallopeptidase 9	Homo sapiens	135-140
24880571-9	2014	Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines.	Corticosterone	12-26	vascular endothelial growth factor A	Homo sapiens	142-146
24880571-9	2014	Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines.	Corticosterone	12-26	interleukin 6	Homo sapiens	152-156
24880571-9	2014	Conversely, corticosterone, prednisone, and dexamethasone similarly inhibited cell invasion and expression of related genes, including MMP-9, VEGF, and IL-6, in GR-positive lines.	Corticosterone	12-26	nuclear receptor subfamily 3 group C member 1	Homo sapiens	161-163
24681250-4	2014	Following both intraperitoneal and intravenous administration of IL-1beta, mice lacking IL-1R1 in hematopoietic cells showed induced expression of the activity marker c-Fos in the paraventricular hypothalamic nucleus, and increased plasma levels of ACTH and corticosterone.	Corticosterone	258-272	interleukin 1 receptor, type I	Mus musculus	88-94
24556017-0	2014	Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia.	Corticosterone	0-14	reelin	Mus musculus	71-77
24815884-0	2014	Regulation of gene expression of vasotocin and corticotropin-releasing hormone receptors in the avian anterior pituitary by corticosterone.	Corticosterone	124-138	corticotropin releasing hormone	Gallus gallus	47-78
24815884-2	2014	Radioimmunoassay results showed that blood circulating corticosterone (CORT) levels in the CS group were significantly decreased compared to that of birds in the AS group (P&lt;0.05).	Corticosterone	55-69	CORT	Gallus gallus	71-75
24556017-0	2014	Corticosterone treatment during adolescence induces down-regulation of reelin and NMDA receptor subunit GLUN2C expression only in male mice: implications for schizophrenia.	Corticosterone	0-14	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	Mus musculus	104-110
24563185-8	2014	Consistent with the anxiety profile, PDE4A KO mice had elevated corticosterone levels compared with wild-type controls post-stress.	Corticosterone	64-78	phosphodiesterase 4A, cAMP specific	Mus musculus	37-42
24928939-7	2014	Total and HDL-associated cholesterol levels, as well as ACTH plasma levels, were increased in both Scarb1-null genders, the latter being concurrent to impaired corticosterone response to fasting.	Corticosterone	160-174	scavenger receptor class B, member 1	Mus musculus	99-105
24907687-0	2014	Long-term differential effects of chronic young-adult corticosterone exposure on anxiety and depression-like behaviour in BDNF heterozygous rats depend on the experimental paradigm used.	Corticosterone	54-68	brain-derived neurotrophic factor	Rattus norvegicus	122-126
24829502-0	2014	Elevated corticosterone in the dorsal hindbrain increases plasma norepinephrine and neuropeptide Y, and recruits a vasopressin response to stress.	Corticosterone	9-23	arginine vasopressin	Rattus norvegicus	115-126
24829502-2	2014	We hypothesized that elevated corticosterone (Cort) within the dorsal hindbrain (DHB) would: 1) enhance arterial pressure and neuroendocrine responses to novel and repeated restraint stress, 2) increase c-Fos expression in regions of the brain involved in sympathetic stimulation during stress, and 3) recruit a vasopressin-mediated blood pressure response to acute stress.	Corticosterone	30-44	cortistatin	Rattus norvegicus	46-50
24829502-0	2014	Elevated corticosterone in the dorsal hindbrain increases plasma norepinephrine and neuropeptide Y, and recruits a vasopressin response to stress.	Corticosterone	9-23	neuropeptide Y	Rattus norvegicus	84-98
25019607-4	2014	Blockade of mGluR5 with MPEP (1 mg kg(-1) for 4 days) increased corticosterone but not catecholamine release during restraint stress (20 min).	Corticosterone	64-78	glutamate receptor, ionotropic, kainate 1	Mus musculus	12-18
25019607-7	2014	Pharmacological blockade of mGluR5 has a modest influence on the hypothalamic-pituitary-adrenocortical axis, as reflected in adrenal hypertrophy and increased corticosterone concentrations.	Corticosterone	159-173	glutamate receptor, ionotropic, kainate 1	Mus musculus	28-34
24829502-2	2014	We hypothesized that elevated corticosterone (Cort) within the dorsal hindbrain (DHB) would: 1) enhance arterial pressure and neuroendocrine responses to novel and repeated restraint stress, 2) increase c-Fos expression in regions of the brain involved in sympathetic stimulation during stress, and 3) recruit a vasopressin-mediated blood pressure response to acute stress.	Corticosterone	30-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	203-208
24829502-2	2014	We hypothesized that elevated corticosterone (Cort) within the dorsal hindbrain (DHB) would: 1) enhance arterial pressure and neuroendocrine responses to novel and repeated restraint stress, 2) increase c-Fos expression in regions of the brain involved in sympathetic stimulation during stress, and 3) recruit a vasopressin-mediated blood pressure response to acute stress.	Corticosterone	30-44	arginine vasopressin	Rattus norvegicus	312-323
24717552-13	2014	These effects may contribute to the inhibition of the expression of SF-1 and its associated steroidogenic enzymes and the production of corticosterone during fetal development.	Corticosterone	136-150	splicing factor 1	Rattus norvegicus	68-72
24667322-3	2014	In this study, we assessed the neuroprotective effect of IGF-II on corticosterone-induced oxidative damage in adult cortical neuronal cultures and the role of IGF-II receptors in this effect.	Corticosterone	67-81	insulin like growth factor 2	Homo sapiens	57-63
23331637-4	2014	The relation between corticosterone (CORT) and FPS behavior was explored in four experiments.	Corticosterone	21-35	cortistatin	Mus musculus	37-41
24944027-9	2014	Under most conditions, 11beta-HSD1 acts as a reductase and activates cortisol/corticosterone, amplifying circulating levels.	Corticosterone	78-92	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	23-34
24742195-10	2014	Subcutaneous implantation of a sustained-release corticosterone pellet decreased the expression of NMB mRNA as well as pituitary proopiomelanocortin mRNA.	Corticosterone	49-63	neuromedin B	Mus musculus	99-102
24708241-10	2014	Neither AVP nor CRH receptor antagonists affected the senktide-induced suppression of the LH pulse; however, antagonism of type 2 CRH receptors attenuated the accompanying elevation of corticosterone levels.	Corticosterone	185-199	corticotropin releasing hormone	Rattus norvegicus	130-133
24798037-7	2014	Plasma corticosterone, which was increased due to stress, was significantly decreased in the F13A + WIRS group.	Corticosterone	7-21	coagulation factor XIII A1 chain	Rattus norvegicus	93-97
24513633-1	2014	The rodent stress hormone corticosterone rapidly enhances long-term potentiation in the CA1 hippocampal area, but leads to a suppression when acting in a more delayed fashion.	Corticosterone	26-40	carbonic anhydrase 1	Mus musculus	88-91
24816193-6	2014	Moreover, it was found that brain-derived neurotrophic factor protein and mRNA levels in the hippocampus were significantly decreased in corticosterone-treated mice.	Corticosterone	137-151	brain derived neurotrophic factor	Mus musculus	28-61
24816193-8	2014	The results suggest that piperine produces an antidepressant-like effect in corticosterone-treated mice, which is possibly mediated by increasing brain-derived neurotrophic factor expression in the hippocampus.	Corticosterone	76-90	brain derived neurotrophic factor	Mus musculus	146-179
24744279-3	2014	We assessed the effects of local climate (wind, sun and ambient temperature) and social conditions (number of neighbours, distance to neighbours) on the baseline levels of plasma total corticosterone (CORT) in 77 incubating and 42 chick-brooding birds, breeding on territories of central or peripheral colony location.	Corticosterone	185-199	CORT	Gallus gallus	201-205
24845172-0	2014	Pituitary adenylate cyclase-activating polypeptide (PACAP) in the bed nucleus of the stria terminalis (BNST) increases corticosterone in male and female rats.	Corticosterone	119-133	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
24845172-0	2014	Pituitary adenylate cyclase-activating polypeptide (PACAP) in the bed nucleus of the stria terminalis (BNST) increases corticosterone in male and female rats.	Corticosterone	119-133	adenylate cyclase activating polypeptide 1	Rattus norvegicus	52-57
24845182-5	2014	Here we show that acute corticosterone exposure induced posttranslational upregulation of TrkB in primary cortical neurons (days in vitro 4, DIV4), which was blocked by the proteasome inhibitors.	Corticosterone	24-38	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	90-94
24845182-6	2014	Acute corticosterone-induced increase in TrkB protein levels was dependent on glucocorticoid receptor (GR).	Corticosterone	6-20	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	41-45
24845182-6	2014	Acute corticosterone-induced increase in TrkB protein levels was dependent on glucocorticoid receptor (GR).	Corticosterone	6-20	nuclear receptor subfamily 3, group C, member 1	Mus musculus	78-101
24845182-6	2014	Acute corticosterone-induced increase in TrkB protein levels was dependent on glucocorticoid receptor (GR).	Corticosterone	6-20	nuclear receptor subfamily 3, group C, member 1	Mus musculus	103-105
24845182-7	2014	At the cellular level, ubiquitin E3 ligase c-Cbl mediates TrkB stabilization and corticosterone-induced TrkB levels.	Corticosterone	81-95	Casitas B-lineage lymphoma	Mus musculus	43-48
24845182-7	2014	At the cellular level, ubiquitin E3 ligase c-Cbl mediates TrkB stabilization and corticosterone-induced TrkB levels.	Corticosterone	81-95	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	104-108
24845182-8	2014	Moreover, the tyrosine kinase binding domain in c-Cbl plays a critical role in corticosterone-induced TrkB levels.	Corticosterone	79-93	Casitas B-lineage lymphoma	Mus musculus	48-53
24845182-8	2014	Moreover, the tyrosine kinase binding domain in c-Cbl plays a critical role in corticosterone-induced TrkB levels.	Corticosterone	79-93	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	102-106
24845182-9	2014	Chronic treatment of neurons with corticosterone induced significant decreases in both TrkB and c-Cbl protein levels.	Corticosterone	34-48	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	87-91
24845182-9	2014	Chronic treatment of neurons with corticosterone induced significant decreases in both TrkB and c-Cbl protein levels.	Corticosterone	34-48	Casitas B-lineage lymphoma	Mus musculus	96-101
24845182-10	2014	Acute corticosterone treatment failed to induce any significant change in TrkB and c-Cbl protein levels in mature neurons (DIV 12), where as chronic corticosterone exposure reduced TrkB levels.	Corticosterone	149-163	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	181-185
24845182-11	2014	Under an in vivo condition, chronic corticosterone exposure induced down-regulation of c-Cbl in mouse frontal cortex and hippocampus.	Corticosterone	36-50	Casitas B-lineage lymphoma	Mus musculus	87-92
24845185-6	2014	We found that NTS GR antagonism increased acute stress-induced corticosterone levels, whereas GR activation within the NTS attenuated this response.	Corticosterone	63-77	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	18-20
24845185-7	2014	Following CVS, basal and 15 min post-restraint plasma corticosterone levels were increased by NTS GR antagonism, which was associated with an increase in Fos immunoreactivity within the PVN.	Corticosterone	54-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	154-157
24967970-10	2014	All these data suggested that corticosterone triggered by chronic stress impaired liver injury repair by MSCs through inhibiting TGF-beta1 expression which results in reduced MFs differentiation of MSCs.	Corticosterone	30-44	transforming growth factor, beta 1	Mus musculus	129-138
24472498-9	2014	These findings indicate that stress-induced corticosterone and consequent activation of hepatic TDO, tryptophan metabolism and production of kynurenine provoke a depression-related behavioural phenotype.	Corticosterone	44-58	tryptophan 2,3-dioxygenase	Rattus norvegicus	96-99
25061562-7	2014	These results demonstrate catecholaminergic NPY signalling is critical in mediating diet- and chronic stress-induced fat gain via effects on diet-induced thermogenesis and stress-induced increases in corticosterone levels and lipogenic capacity.	Corticosterone	200-214	neuropeptide Y	Mus musculus	44-47
24603007-0	2014	Corticosterone-induced enhancement of memory and synaptic Arc protein in the medial prefrontal cortex.	Corticosterone	0-14	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	58-61
24603007-2	2014	Posttraining administration of corticosterone increases expression of the activity-regulated cytoskeletal-associated protein (Arc) in hippocampal synaptic-enriched fractions.	Corticosterone	31-45	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	74-124
24603007-2	2014	Posttraining administration of corticosterone increases expression of the activity-regulated cytoskeletal-associated protein (Arc) in hippocampal synaptic-enriched fractions.	Corticosterone	31-45	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	126-129
24603007-3	2014	Interference with hippocampal Arc expression impairs memory, suggesting that the corticosterone-induced increase in hippocampal Arc plays a role in the memory enhancing effect of the hormone.	Corticosterone	81-95	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	30-33
24603007-3	2014	Interference with hippocampal Arc expression impairs memory, suggesting that the corticosterone-induced increase in hippocampal Arc plays a role in the memory enhancing effect of the hormone.	Corticosterone	81-95	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	128-131
24603007-4	2014	Blockade of beta-adrenoceptors in the BLA attenuates the corticosterone-induced increase in hippocampal Arc expression and blocks corticosterone-induced memory enhancement.	Corticosterone	57-71	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	104-107
24603007-9	2014	Although this treatment blocked corticosterone-induced memory enhancement, it increased corticosterone-induced Arc protein expression in mPFC synaptic fractions.	Corticosterone	88-102	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	111-114
24750490-9	2014	Furthermore, MPA (1 and 4 mg) and MPA + EB treated animals had significantly lower adrenal/body mass ratios and reduced serum corticosterone (CORT) levels.	Corticosterone	126-140	cortistatin	Rattus norvegicus	142-146
24976758-0	2014	Alpha-Asarone, a Major Component of Acorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process.	Corticosterone	65-79	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	127-131
24884833-2	2014	Acute treatment with a single dose of corticosterone (CORT; predominant glucocorticoid of rats) alone has previously been shown to trigger anxiety behavior and robust dendritic hypertrophy of neurons in the basolateral amygdala (BLA).	Corticosterone	38-52	cortistatin	Rattus norvegicus	54-58
25029334-1	2014	Petroleum can disrupt endocrine function in humans and wildlife, and interacts in particularly complex ways with the hypothalamus-pituitary-adrenal (HPA) axis, responsible for the release of the stress hormones corticosterone and cortisol (hereafter CORT).	Corticosterone	211-225	cortistatin	Homo sapiens	250-254
24578294-8	2014	Intracerebroventricular (i.c.v) administration of H3 (5 nmol) significantly increased plasma corticosterone at 30 min following injection compared with vehicle.	Corticosterone	93-107	relaxin 3	Homo sapiens	50-52
24578294-9	2014	Intra-PVN administration of H3 (1.8-1620 pmol) significantly increased plasma ACTH at 1620 pmol H3 and corticosterone at 180-1620 pmol H3 at 30 min following injection compared with vehicle.	Corticosterone	103-117	relaxin 3	Homo sapiens	28-30
24630043-2	2014	However, whether corticosterone (CORT) causes similar effects in the chicken remains unclear.	Corticosterone	17-31	CORT	Gallus gallus	33-37
24422972-0	2014	Aquaporin-4 knockout exacerbates corticosterone-induced depression by inhibiting astrocyte function and hippocampal neurogenesis.	Corticosterone	33-47	aquaporin 4	Mus musculus	0-11
24422972-4	2014	Forced swimming test (FST) and tail suspension test (TST) showed longer immobility times in corticosterone-treated AQP4(-/-) genotype, indicating AQP4 knockout exacerbated depressive-like behaviors in mice.	Corticosterone	92-106	aquaporin 4	Mus musculus	115-119
24422972-4	2014	Forced swimming test (FST) and tail suspension test (TST) showed longer immobility times in corticosterone-treated AQP4(-/-) genotype, indicating AQP4 knockout exacerbated depressive-like behaviors in mice.	Corticosterone	92-106	aquaporin 4	Mus musculus	146-150
24422972-6	2014	Moreover, even less hippocampal neurogenesis was identified in corticosterone-treated AQP4(-/-) mice in vivo and hippocampus-derived adult neural stem cells (ANSCs) in vitro.	Corticosterone	63-77	aquaporin 4	Mus musculus	86-90
24552400-6	2014	We next showed that 24 hours of treatment with corticosterone (CORT) increase GnIH mRNA expression in the quail diencephalon.	Corticosterone	47-61	cortistatin	Rattus norvegicus	63-67
24311359-7	2014	RESULTS: Corticosterone administration (PC group) resulted, in adolescence, in a reduction in body weight and locomotion, while in adulthood, in increased anxiety-related behavior and reduced CB1Rs expression in cerebellum.	Corticosterone	9-23	cannabinoid receptor 1 (brain)	Mus musculus	192-195
24155262-7	2014	Moreover, injection of 2,3-dichloro-a-methylbenzylamine, a PNMT enzyme inhibitor, (10 mg/kg) before corticosterone treatment caused a leftward shift in the dose-response curve for corticosterone and injection of propranolol (5 mg/kg), but not phentolamine, also shifted the dose-response curve to the left during the late phase.	Corticosterone	180-194	phenylethanolamine-N-methyltransferase	Mus musculus	59-63
24690172-0	2014	Leptin reverses corticosterone-induced inhibition of neural stem cell proliferation through activating the NR2B subunits of NMDA receptors.	Corticosterone	16-30	leptin	Homo sapiens	0-6
24690172-0	2014	Leptin reverses corticosterone-induced inhibition of neural stem cell proliferation through activating the NR2B subunits of NMDA receptors.	Corticosterone	16-30	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	107-111
24690172-6	2014	Interestingly, pre-treatment with non-specific NMDA antagonist MK-801, specific NR2B antagonist Ro 25-6981, or small interfering RNA (siRNA) targeting NR2B, significantly blocked the effect of leptin on corticosterone-induced inhibition of NSCs proliferation.	Corticosterone	203-217	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	80-84
24690172-3	2014	Leptin has been shown to regulate brain development, improve angiogenesis, and promote neural regeneration; however, its effects on corticosterone-induced inhibition of NSCs proliferation remain unclear.	Corticosterone	132-146	leptin	Homo sapiens	0-6
24690172-6	2014	Interestingly, pre-treatment with non-specific NMDA antagonist MK-801, specific NR2B antagonist Ro 25-6981, or small interfering RNA (siRNA) targeting NR2B, significantly blocked the effect of leptin on corticosterone-induced inhibition of NSCs proliferation.	Corticosterone	203-217	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	151-155
24690172-5	2014	Also, leptin efficiently reversed the inhibition of NSCs proliferation induced by corticosterone.	Corticosterone	82-96	leptin	Homo sapiens	6-12
24690172-6	2014	Interestingly, pre-treatment with non-specific NMDA antagonist MK-801, specific NR2B antagonist Ro 25-6981, or small interfering RNA (siRNA) targeting NR2B, significantly blocked the effect of leptin on corticosterone-induced inhibition of NSCs proliferation.	Corticosterone	203-217	leptin	Homo sapiens	193-199
24582675-6	2014	RESULTS: HSS increased blood corticosterone in dams of PS2 (Pregnancy Stress second half), and also in adult male offspring from BPS (Before Pregnancy Stress) and PS1 (Pregnancy Stress first half) groups.	Corticosterone	29-43	trefoil factor 1	Rattus norvegicus	55-58
24690172-7	2014	Furthermore, corticosterone significantly reduced the protein expression of NR2B, whereas pre-treatment with leptin greatly reversed the attenuation of NR2B expression caused by corticosterone in cultured hippocampal NSCs.	Corticosterone	13-27	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	76-80
24690172-7	2014	Furthermore, corticosterone significantly reduced the protein expression of NR2B, whereas pre-treatment with leptin greatly reversed the attenuation of NR2B expression caused by corticosterone in cultured hippocampal NSCs.	Corticosterone	178-192	leptin	Homo sapiens	109-115
24690172-7	2014	Furthermore, corticosterone significantly reduced the protein expression of NR2B, whereas pre-treatment with leptin greatly reversed the attenuation of NR2B expression caused by corticosterone in cultured hippocampal NSCs.	Corticosterone	178-192	glutamate ionotropic receptor NMDA type subunit 2B	Homo sapiens	152-156
24690172-8	2014	Our findings demonstrate that leptin reverses the corticosterone-induced inhibition of NSCs proliferation.	Corticosterone	50-64	leptin	Homo sapiens	30-36
24687160-6	2014	Corticosterone levels were negatively associated with the numbers of CD19(+) (r(2) = 0.43, p = 0.0017), CD4(+) (r(2) = 0.28, p = 0.0154) and CD8(+) cells (r(2) = 0.20, p = 0.0503).	Corticosterone	0-14	CD19 antigen	Mus musculus	69-73
24687160-6	2014	Corticosterone levels were negatively associated with the numbers of CD19(+) (r(2) = 0.43, p = 0.0017), CD4(+) (r(2) = 0.28, p = 0.0154) and CD8(+) cells (r(2) = 0.20, p = 0.0503).	Corticosterone	0-14	CD4 antigen	Mus musculus	104-107
24534266-4	2014	This treatment revealed corticosterone-dependent increases in microglial number and accumulation of the pro-inflammatory cytokines interleukin 1beta and tumor necrosis factor alpha in the hippocampus of db/db mice.	Corticosterone	24-38	interleukin 1 beta	Mus musculus	131-180
24503116-6	2014	Separated CCR7(-/-) mice also exhibited significantly lower serum corticosterone concentrations compared to non-separated mice.	Corticosterone	66-80	chemokine (C-C motif) receptor 7	Mus musculus	10-14
24782729-11	2014	Reduced expression of BDNF was only found in submissive animals that also exhibit elevated NPS expression, despite elevated corticosterone in all socially interacting animals.	Corticosterone	124-138	brain derived neurotrophic factor	Mus musculus	22-26
24782729-12	2014	The results suggest an interwoven relationship, linked by social context, between amygdalar BDNF, NPS and plasma corticosterone.	Corticosterone	113-127	brain derived neurotrophic factor	Mus musculus	92-96
24484650-7	2014	In addition, ICV injection of CRH but not UCN-3 increased plasma corticosterone concentration (P &lt; 0.05) and decreased the diencephalic mRNA expression of CRH-R1 (P &lt; 0.05).	Corticosterone	65-79	corticotropin releasing hormone	Gallus gallus	30-33
24339278-10	2014	Re-exposed groups had lower corticosterone plasma level (P1P21 M and F, P8P21M) than controls.	Corticosterone	28-42	KRAS proto-oncogene, GTPase	Rattus norvegicus	57-62
24354785-10	2014	This might result from lower levels of free corticosterone in FKBP51KO mice, confirming reduced HPA reactivity.	Corticosterone	44-58	FK506 binding protein 5	Mus musculus	62-68
24690945-10	2014	We found that (1) exposure to stress in childhood and adolescence increased anxiety-like behavior in adulthood; (2) the herbal treatment reduced anxiety-like behavior, both when treated during or following exposure to stress; (3) blood corticosterone levels were reduced following treatment with the herbal treatment or escitalopram, when treated during or following exposure to stress; (4) brain derived neurotrophic factor levels in the hippocampus of mice treated with the herbal treatment or escitalopram were increased, when treated either during or following exposure to stress.	Corticosterone	236-250	brain derived neurotrophic factor	Mus musculus	391-424
24636497-6	2014	The results indicated that corticosterone and prostaglandins are prominent mediators of the IL-12-suppressing effects of stress and surgery, apparently through directly suppressing leukocyte IL-12 production.	Corticosterone	27-41	interleukin 12B	Rattus norvegicus	92-97
24636497-6	2014	The results indicated that corticosterone and prostaglandins are prominent mediators of the IL-12-suppressing effects of stress and surgery, apparently through directly suppressing leukocyte IL-12 production.	Corticosterone	27-41	interleukin 12B	Rattus norvegicus	191-196
24636497-9	2014	Last, a whole blood in vitro study indicated that prostaglandins and corticosterone, but not epinephrine, suppressed IL-12 production in non-stimulated leukocytes, and only corticosterone did so in the context of CpG-C-induced IL-12 production.	Corticosterone	69-83	interleukin 12B	Rattus norvegicus	117-122
24636497-9	2014	Last, a whole blood in vitro study indicated that prostaglandins and corticosterone, but not epinephrine, suppressed IL-12 production in non-stimulated leukocytes, and only corticosterone did so in the context of CpG-C-induced IL-12 production.	Corticosterone	69-83	interleukin 12B	Rattus norvegicus	227-232
24636497-11	2014	Herein, corticosterone and prostaglandins, but not catecholamines or opioids, were key mediators of the suppressive effect of stress and surgery on in vivo plasma IL-12 levels in otherwise naive animals.	Corticosterone	8-22	interleukin 12B	Rattus norvegicus	163-168
24636513-4	2014	Synaptic deficits evoked by exposure to elevated corticosterone levels in db/db mice are attributable to glucocorticoid receptor-mediated transrepression of AP-1 actions at BDNF promoters I and IV.	Corticosterone	49-63	nuclear receptor subfamily 3, group C, member 1	Mus musculus	105-128
24636513-4	2014	Synaptic deficits evoked by exposure to elevated corticosterone levels in db/db mice are attributable to glucocorticoid receptor-mediated transrepression of AP-1 actions at BDNF promoters I and IV.	Corticosterone	49-63	brain derived neurotrophic factor	Mus musculus	173-177
24636513-5	2014	db/db mice exhibit corticosterone-mediated reductions in brain-derived neurotrophic factor (BDNF), and a change in the ratio of TrkB to P75NTR that silences the functional response to BDNF stimulation.	Corticosterone	19-33	brain derived neurotrophic factor	Mus musculus	57-90
24636513-5	2014	db/db mice exhibit corticosterone-mediated reductions in brain-derived neurotrophic factor (BDNF), and a change in the ratio of TrkB to P75NTR that silences the functional response to BDNF stimulation.	Corticosterone	19-33	brain derived neurotrophic factor	Mus musculus	92-96
24398264-4	2014	We investigated for the first time whether neonatal exposure to TNF-alpha can affect body weight, stress-induced corticosterone (COR), anxiety- and depression-related behaviors in adult mice.	Corticosterone	113-127	tumor necrosis factor	Mus musculus	64-73
24618807-2	2014	Here, we examined the effects of a history of chronic exposure to the stress-associated adrenal steroid corticosterone (CORT) on the consolidation of a fear memory and the expression of memory-related immediate early genes (IEGs) in the lateral nucleus of the amygdala (LA).	Corticosterone	104-118	cortistatin	Rattus norvegicus	120-124
24468157-0	2014	Corticosterone accelerates atherosclerosis in the apolipoprotein E-deficient mouse.	Corticosterone	0-14	apolipoprotein E	Mus musculus	50-66
24490859-9	2014	The principal finding of the present study was that plasma ACTH and corticosterone levels, MB-COMT, S-COMT, NA turnover, and Hsp27 expression and activation observed during morphine withdrawal were significantly inhibited in the CRF1 receptor-knockout mice.	Corticosterone	68-82	corticotropin releasing hormone receptor 1	Mus musculus	229-242
24269865-0	2014	Short-term psychosocial stress protects photoreceptors from damage via corticosterone-mediated activation of the AKT pathway.	Corticosterone	71-85	thymoma viral proto-oncogene 1	Mus musculus	113-116
24333411-2	2014	Whether prenatal corticosterone (CORT) exposure causes similar effects in avian species is less clear.	Corticosterone	17-31	CORT	Gallus gallus	33-37
24293639-4	2014	Leptin also partially, but significantly, reversed the low plasma thyroxine and high corticosterone levels found in Agpat2(-/-) mice.	Corticosterone	85-99	1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta)	Mus musculus	116-122
24306280-5	2014	Further, F-DPS normalized serum levels of corticosterone and adrenocorticotropic hormone, which were increased after corticosterone exposure.	Corticosterone	117-131	pro-opiomelanocortin-alpha	Mus musculus	61-88
24311359-0	2014	Prenatal corticosterone and adolescent URB597 administration modulate emotionality and CB1 receptor expression in mice.	Corticosterone	9-23	cannabinoid receptor 1 (brain)	Mus musculus	87-90
24464022-2	2014	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) activates GCs (converting 11-dehydrocorticosterone to corticosterone in rodents) in many tissues including skin, where de novo steroidogenesis from cholesterol has also been reported.	Corticosterone	93-107	RNA, U1 small nuclear 1	Homo sapiens	0-55
24464022-6	2014	Although several steroidogenic enzymes displayed variable expression during healing, expression of the final enzyme required for the conversion of 11-deoxycorticosterone to corticosterone, 11beta-hydroxylase (CYP11B1), was lacking in unwounded skin and post-wounding.	Corticosterone	155-169	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	209-216
24464022-8	2014	Our findings demonstrate that 11beta-HSD1 activates considerably more corticosterone than is generated de novo from progesterone in mouse skin and drives GC exposure during healing, demonstrating the basis for 11beta-HSD1 inhibitors to accelerate wound repair.	Corticosterone	70-84	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	30-41
24464022-8	2014	Our findings demonstrate that 11beta-HSD1 activates considerably more corticosterone than is generated de novo from progesterone in mouse skin and drives GC exposure during healing, demonstrating the basis for 11beta-HSD1 inhibitors to accelerate wound repair.	Corticosterone	70-84	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	210-221
24507876-11	2014	Stressed LAP2 mice had increased basal circulating corticosterone on the final stress exposure day compared to non-stressed LAP2 mice, and no difference was found between stressed and non-stressed HAP2 mice.	Corticosterone	51-65	leucine aminopeptidase 2, serum	Mus musculus	9-13
24381005-4	2014	Transgenic aP2/H6PDH mice exhibited relatively high expression of H6PDH and elevated corticosterone production with induction of 11beta-HSD1 activity in adipose tissue.	Corticosterone	85-99	fatty acid binding protein 4, adipocyte	Mus musculus	11-14
24381005-5	2014	This increase in corticosterone production in aP2-H6PDH Tg mice resulted in mild abdominal fat accumulation with induction of C/EBP mRNA expression and slight weight gain.	Corticosterone	17-31	fatty acid binding protein 4, adipocyte	Mus musculus	46-49
24381005-5	2014	This increase in corticosterone production in aP2-H6PDH Tg mice resulted in mild abdominal fat accumulation with induction of C/EBP mRNA expression and slight weight gain.	Corticosterone	17-31	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	126-131
24580729-11	2014	CONCLUSION: Progesterone is present at high levels during gestation and the product of 21-hydroxylase, deoxycorticosterone, can bind the glucocorticoid receptor with an affinity close to that of corticosterone.	Corticosterone	108-122	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	87-101
24389091-0	2014	Effects of tonic immobility (TI) and corticosterone (CORT) on energy status and protein metabolism in pectoralis major muscle of broiler chickens.	Corticosterone	37-51	CORT	Gallus gallus	53-57
24389091-2	2014	Our previous study has demonstrated LTI phenotype and chronic corticosterone (CORT) administration retarded growth of breast muscle in broiler chickens.	Corticosterone	62-76	CORT	Gallus gallus	78-82
24302625-3	2014	Crh(-120/+) mice, when compared with wild-type littermates, had obesity, muscle wasting, thin skin, hair loss, and elevated plasma and urinary concentrations of corticosterone.	Corticosterone	161-175	corticotropin releasing hormone	Mus musculus	0-3
24424066-9	2014	Reduced SCGRKO testicular expression of Hsd11b2, encoding an enzyme for corticosterone inactivation, supports a dynamic coupling between Hsd11b and androgen production.	Corticosterone	72-86	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	40-47
24388462-2	2014	Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT).	Corticosterone	150-164	arginine vasopressin receptor 2	Mus musculus	84-87
24388462-2	2014	Herein, we have described a mouse model of a depression-like and insulin-resistant (DIR) state induced by the co-treatment of high-fat diet (HFD) and corticosterone (CORT).	Corticosterone	150-164	cortistatin	Mus musculus	166-170
24428719-7	2014	Membrane impermeable glucocorticoid, corticosterone-bovine serum albumin conjugate (CSBSA), was found to have effects similar to those of DEX and free corticosterone (CS), suggesting that glucocorticoids regulate GH gene transcription at least in part through the membrane bound receptors.	Corticosterone	37-51	gonadotropin releasing hormone receptor	Rattus norvegicus	213-215
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Corticosterone	134-148	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	17-22
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Corticosterone	134-148	solute carrier family 22 member 3	Homo sapiens	18-22
23982114-8	2014	ASP(+) uptake by mOCT3 and human OCT3 (hOCT3) was efficiently inhibited by 1-methyl-4-phenylpyridinium, tetrapentylammonium (TPA(+)), corticosterone, serotonin, and histamine and by the drugs ketamine, fluoxetine, and diazepam.	Corticosterone	134-148	solute carrier family 22 member 3	Homo sapiens	39-44
24495609-0	2014	Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors.	Corticosterone	40-54	gamma-aminobutyric acid (GABA) A receptor, subunit delta	Mus musculus	8-13
24495609-0	2014	Loss of Gabrd in CRH neurons blunts the corticosterone response to stress and diminishes stress-related behaviors.	Corticosterone	40-54	corticotropin releasing hormone	Mus musculus	17-20
24252379-1	2014	Corticosteroid binding globulin (CBG) is a glycoprotein synthesized in liver and secreted in the blood where it binds with a high affinity but low capacity glucocorticoid hormones, cortisol in humans and corticosterone in laboratory rodents.	Corticosterone	204-218	serpin family A member 6	Homo sapiens	0-31
24252379-1	2014	Corticosteroid binding globulin (CBG) is a glycoprotein synthesized in liver and secreted in the blood where it binds with a high affinity but low capacity glucocorticoid hormones, cortisol in humans and corticosterone in laboratory rodents.	Corticosterone	204-218	serpin family A member 6	Homo sapiens	33-36
24463096-6	2014	Caffeine administration reduced maternal weight gains and elevated both maternal and fetal corticosterone (CORT) levels.	Corticosterone	91-105	cortistatin	Rattus norvegicus	107-111
24570488-5	2014	We screened for cytokines that regulated intestinal glucocorticoid synthesis and found that TNF suppressed corticosterone secretion and Cyp11a1 and Cyp11b1 expression in an intestinal crypt epithelial cell line.	Corticosterone	107-121	tumor necrosis factor	Mus musculus	92-95
24413279-1	2014	The activity of the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which converts inactive cortisone (11-dehydrocorticosterone (11-DHC)) (in mice) into the active glucocorticoid (GC) cortisol (corticosterone in mice), can amplify tissue GC exposure.	Corticosterone	130-144	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	71-82
24567706-2	2014	This process of discrimination and decision-making is stressful and triggers secretion of corticosterone activating mineralocorticoid receptor (MR) and glucocorticoid receptor (GR).	Corticosterone	90-104	nuclear receptor subfamily 3, group C, member 2	Mus musculus	116-142
24567706-2	2014	This process of discrimination and decision-making is stressful and triggers secretion of corticosterone activating mineralocorticoid receptor (MR) and glucocorticoid receptor (GR).	Corticosterone	90-104	nuclear receptor subfamily 3, group C, member 2	Mus musculus	144-146
24567706-2	2014	This process of discrimination and decision-making is stressful and triggers secretion of corticosterone activating mineralocorticoid receptor (MR) and glucocorticoid receptor (GR).	Corticosterone	90-104	nuclear receptor subfamily 3, group C, member 1	Mus musculus	152-175
24567706-2	2014	This process of discrimination and decision-making is stressful and triggers secretion of corticosterone activating mineralocorticoid receptor (MR) and glucocorticoid receptor (GR).	Corticosterone	90-104	nuclear receptor subfamily 3, group C, member 1	Mus musculus	177-179
24550796-5	2014	Thus, we have studied the effects of a vitamin A-free diet for 14 weeks and a 4-week vitamin A supplementation on plasma and hippocampal corticosterone (CORT) levels in Wistar rats.	Corticosterone	137-151	cortistatin	Rattus norvegicus	153-157
24316201-1	2014	Studies in male rodents have shown that stress-induced increases in circulating corticosterone are increased by both CB1 receptor (CB1R) antagonist treatment and genetic deletion.	Corticosterone	80-94	cannabinoid receptor 1 (brain)	Mus musculus	117-129
24042478-6	2014	Assessment of core temperature and corticosterone secretion revealed a significantly blunted response of the autonomic nervous system and the hypothalamic-pituitary-adrenal axis in Ahi1(+/-) mice exposed to environmental and visceral stress.	Corticosterone	35-49	Abelson helper integration site 1	Mus musculus	181-185
25129992-7	2014	Administration of a non-antihypertensive dose of the MR antagonist spironolactone (20 mg/kg per day) from 6 weeks inhibited the effects of corticosterone on both the collagen type I to type III mRNA ratio and diastolic function without affecting the decrease in LV mass.	Corticosterone	139-153	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	53-55
24148811-9	2014	Proliferative cell rate in the dentate gyrus was the highest in P8 males and females (P &lt; 0.001), with males exhibiting more proliferation than females on P1 and P8, which was directly related to the hippocampal levels of BDNF and inversely related to plasma corticosterone.	Corticosterone	262-276	perforin 1	Rattus norvegicus	158-167
24148811-9	2014	Proliferative cell rate in the dentate gyrus was the highest in P8 males and females (P &lt; 0.001), with males exhibiting more proliferation than females on P1 and P8, which was directly related to the hippocampal levels of BDNF and inversely related to plasma corticosterone.	Corticosterone	262-276	brain-derived neurotrophic factor	Rattus norvegicus	225-229
24316201-1	2014	Studies in male rodents have shown that stress-induced increases in circulating corticosterone are increased by both CB1 receptor (CB1R) antagonist treatment and genetic deletion.	Corticosterone	80-94	cannabinoid receptor 1 (brain)	Mus musculus	131-135
24316201-2	2014	The purposes of the current study were to determine whether female mice respond in the same manner as males, and whether indirect CB1R agonists accelerate the return of corticosterone to baseline.	Corticosterone	169-183	cannabinoid receptor 1 (brain)	Mus musculus	130-134
24316201-3	2014	In agreement with earlier studies, CB1R null and rimonabant-treated male mice had significantly increased circulating corticosterone 30 min following the end of a restraint episode compared to wild type and vehicle-treated, respectively.	Corticosterone	118-132	cannabinoid receptor 1 (brain)	Mus musculus	35-39
24316201-5	2014	However, corticosterone concentrations were not different between CB1R null and wild type females at 30 min recovery, although CB1R null mice had higher corticosterone concentrations at 90 min of recovery.	Corticosterone	153-167	cannabinoid receptor 1 (brain)	Mus musculus	127-131
24316201-6	2014	Female CB1R null mice exhibited greater serum binding capacity for corticosterone than wild type.	Corticosterone	67-81	cannabinoid receptor 1 (brain)	Mus musculus	7-11
24316201-7	2014	The monoacylglycerol lipase inhibitor, JZL184, attenuated corticosterone concentrations at restraint offset in male, and at 30 min recovery in female mice compared to vehicle.	Corticosterone	58-72	monoglyceride lipase	Mus musculus	4-27
24316201-12	2014	These data support a role for endocannabinoid-CB1R signaling in the regulation of the corticosterone response to restraint stress and suggest that female mice with life-long loss of the CB1R undergo compensatory changes that minimize the impact of loss of endocannabinoid signaling on circulating corticosterone.	Corticosterone	86-100	cannabinoid receptor 1 (brain)	Mus musculus	46-50
24316201-12	2014	These data support a role for endocannabinoid-CB1R signaling in the regulation of the corticosterone response to restraint stress and suggest that female mice with life-long loss of the CB1R undergo compensatory changes that minimize the impact of loss of endocannabinoid signaling on circulating corticosterone.	Corticosterone	86-100	cannabinoid receptor 1 (brain)	Mus musculus	186-190
24316201-12	2014	These data support a role for endocannabinoid-CB1R signaling in the regulation of the corticosterone response to restraint stress and suggest that female mice with life-long loss of the CB1R undergo compensatory changes that minimize the impact of loss of endocannabinoid signaling on circulating corticosterone.	Corticosterone	297-311	cannabinoid receptor 1 (brain)	Mus musculus	186-190
24128867-4	2014	The study also examined the relationship between rats" affective behavior and the plasma corticosterone (CORT) levels in response to chronic repeated restraint stress and series of behavior tests.	Corticosterone	89-103	cortistatin	Rattus norvegicus	105-109
24275070-5	2014	The results showed that, in PEE+ND group, serum corticosterone (CORT) slightly decreased and insulin-like growth factor-1 (IGF-1) and glucose increased with partial catch-up growth; In PEE+HFD group, serum CORT decreased, while serum IGF-1, glucose and triglyceride (TG) increased, with notable catch-up growth, higher metabolic status and NAFLD formation.	Corticosterone	48-62	cortistatin	Rattus norvegicus	64-68
24427122-4	2014	We examined the corticosterone (CORT) response to stress with and without dexamethasone (DEX) and anxiety-like behaviors.	Corticosterone	16-30	cortistatin	Rattus norvegicus	32-36
24239638-10	2014	Challenge-induced bone-marrow eosinophilia and corticosterone surge were abolished in TNFRI-deficient mice.	Corticosterone	47-61	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	86-91
24111919-0	2014	Corticosterone administration up-regulated expression of norepinephrine transporter and dopamine beta-hydroxylase in rat locus coeruleus and its terminal regions.	Corticosterone	0-14	solute carrier family 6 member 2	Rattus norvegicus	57-83
24111919-0	2014	Corticosterone administration up-regulated expression of norepinephrine transporter and dopamine beta-hydroxylase in rat locus coeruleus and its terminal regions.	Corticosterone	0-14	dopamine beta-hydroxylase	Rattus norvegicus	88-113
24111919-5	2014	However, CORT-induced increase in DBH protein levels only appeared in the hippocampus and the amygdala.	Corticosterone	9-13	dopamine beta-hydroxylase	Rattus norvegicus	34-37
24003988-6	2014	Serum corticosterone was more elevated in DP1(-/-) mice after bleo than in wild-type (wt) mice.	Corticosterone	6-20	receptor accessory protein 5	Mus musculus	42-45
24221352-6	2014	OAT activity was found to be regulated in a tissue-specific manner during postnatal development in parallel with large changes in the plasma testosterone and corticosterone levels.	Corticosterone	158-172	ornithine aminotransferase	Mus musculus	0-3
24685581-0	2014	Leptin downregulates LPS-induced lung injury: role of corticosterone and insulin.	Corticosterone	54-68	leptin	Mus musculus	0-6
24901001-3	2014	We studied the ameliorative effect of PYC on depression-like behavior in chronic corticosterone- (CORT-) treated mice for 20 days.	Corticosterone	81-95	cortistatin	Mus musculus	98-102
24685581-12	2014	CONCLUSION: These data suggest that exogenous leptin may promote protection during sepsis, and downregulation of the insulin levels and upregulation of corticosterone may be important mechanisms in the amelioration of LPS-induced ALI.	Corticosterone	152-166	toll-like receptor 4	Mus musculus	218-221
24316399-7	2014	The release of corticosterone was successfully blocked by the pre-treatment of the CRH antagonist alpha-helical CRH9-41.	Corticosterone	15-29	corticotropin releasing hormone	Rattus norvegicus	83-86
24685581-11	2014	LPS induced an increase in corticosterone levels, and leptin potentiated this event.	Corticosterone	27-41	toll-like receptor 4	Mus musculus	0-3
24490674-11	2014	We also found decreased expression levels of 11beta-hydroxysteroid dehydrogenase type 2, suggesting that corticosterone is apt to bind to MR.	Corticosterone	105-119	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	45-87
24490674-0	2014	Corticosterone-activated mineralocorticoid receptor contributes to salt-induced sympathoexcitation in pressure overload mice.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Mus musculus	25-51
24490674-11	2014	We also found decreased expression levels of 11beta-hydroxysteroid dehydrogenase type 2, suggesting that corticosterone is apt to bind to MR.	Corticosterone	105-119	nuclear receptor subfamily 3, group C, member 2	Mus musculus	138-140
24490674-4	2014	Although the role of aldosterone is extensively examined as a ligand for MR, corticosterone is able to bind to MR.	Corticosterone	77-91	nuclear receptor subfamily 3, group C, member 2	Mus musculus	111-113
24490674-12	2014	These results indicate that salt intake in PO-mice causes sympathoexcitation via, at least in part, corticosterone-induced MR and AT1R activation in the hypothalamus.	Corticosterone	100-114	nuclear receptor subfamily 3, group C, member 2	Mus musculus	123-125
24490674-12	2014	These results indicate that salt intake in PO-mice causes sympathoexcitation via, at least in part, corticosterone-induced MR and AT1R activation in the hypothalamus.	Corticosterone	100-114	angiotensin II, type I receptor-associated protein	Mus musculus	130-134
24316334-4	2014	The hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis due to stress procedure was evaluated by the pre- and post-stress levels of circulating corticosterone (CORT).	Corticosterone	155-169	cortistatin	Rattus norvegicus	171-175
24169562-5	2014	In confirmation of our previous results, CSC mice of both mHAB and mNAB lines displayed chronic stress-related symptoms including increased adrenal weight, decreased adrenal in vitro ACTH sensitivity, lower plasma corticosterone to ACTH ratio, and increased interferon-gamma secretion from isolated mesenteric lymph node cells compared with single-housed controls of the respective line.	Corticosterone	214-228	ring finger and CCCH-type zinc finger domains 2	Mus musculus	67-71
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	15-29	nuclear receptor subfamily 3 group C member 2	Homo sapiens	93-119
23749289-0	2014	Baicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the rat.	Corticosterone	26-40	brain-derived neurotrophic factor	Rattus norvegicus	122-155
23749289-0	2014	Baicalin improves chronic corticosterone-induced learning and memory deficits via the enhancement of impaired hippocampal brain-derived neurotrophic factor and cAMP response element-binding protein expression in the rat.	Corticosterone	26-40	cAMP responsive element binding protein 1	Rattus norvegicus	160-197
23749289-1	2014	The purpose of this study was to examine whether baicalin (BAI) improves spatial cognitive impairments induced in rats following the repeated administration of the exogenous stress hormone corticosterone (CORT).	Corticosterone	189-203	cortistatin	Rattus norvegicus	205-209
25611260-0	2014	Corticosterone protects against memory impairments and reduced hippocampal BDNF levels induced by a chronic low dose of ethanol in C57BL/6J mice.	Corticosterone	0-14	brain derived neurotrophic factor	Mus musculus	75-79
25611260-7	2014	The chronic exposure to a low dose of ethanol caused spatial and non-spatial memory deficits after withdrawal associated with a reduction in hippocampal BDNF levels, which were prevented by co-treatment with corticosterone (~21 mg/kg/day).	Corticosterone	208-222	brain derived neurotrophic factor	Mus musculus	153-157
25611260-8	2014	The protective effect of corticosterone on memory was no longer observed at higher doses (~41 mg/kg/day), but persisted for hippocampal BDNF levels.	Corticosterone	25-39	brain derived neurotrophic factor	Mus musculus	136-140
24176792-2	2014	In humans, corticosterone and its 5alpha-Ring A-reduced metabolites are excreted via the bile into the intestine and transformed by anaerobic bacteria to 21-dehydroxylated products: 11beta-OH-progesterone or 11beta-OH-(allo)-5alpha-preganolones (potent inhibitors of 11beta-HSD2 and 11beta-HSD1 dehydrogenase).	Corticosterone	11-25	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	267-278
23994181-2	2013	Most of the changes in behavior, corticosterone (CORT) and monoamine levels induced by long maternal separation (LMS) are observed after a challenge, but not in basal conditions.	Corticosterone	33-47	cortistatin	Mus musculus	49-53
24312665-8	2013	Elevated plasma corticosterone levels and blunted downregulation of 11-beta hydroxysteroid dehydrogenase type 1 in adipose tissue was observed in ANXA1 KO mice compared to diet-matched WT mice.	Corticosterone	16-30	annexin A1	Mus musculus	146-151
23889203-0	2013	Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner.	Corticosterone	22-36	carbonic anhydrase 1	Rattus norvegicus	75-78
23889203-0	2013	Long-term ethanol and corticosterone co-exposure sensitize the hippocampal ca1 region pyramidal cells to insult during ethanol withdrawal in an NMDA GluN2B subunit-dependent manner.	Corticosterone	22-36	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	149-155
23889203-2	2013	Both EtOH and corticosterone (CORT) promote synthesis of polyamines, which allosterically potentiate NMDA receptor function at the GluN2B subunit.	Corticosterone	14-28	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	131-137
23889203-2	2013	Both EtOH and corticosterone (CORT) promote synthesis of polyamines, which allosterically potentiate NMDA receptor function at the GluN2B subunit.	Corticosterone	30-34	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	131-137
23889203-8	2013	Western blot analysis was employed to assess the density of GluN2B subunits following EtOH and CORT exposure.	Corticosterone	95-99	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	60-66
23801153-1	2013	A simple, robust and specific liquid chromatography tandem mass spectrometry (LC-MS/MS) method was developed and validated to determine the concentration of corticosterone (Cort) which is usually regarded as a stress biomarker in mouse serum.	Corticosterone	157-171	cortistatin	Mus musculus	173-177
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	31-35	nuclear receptor subfamily 3 group C member 1	Homo sapiens	158-160
24080854-10	2014	In addition, in TLR9 knockout (KO) mice, chronic stress-induced upregulation of corticosterone levels was significantly decreased.	Corticosterone	80-94	toll-like receptor 9	Mus musculus	16-20
24334056-9	2014	The effects of genistein on the GR levels was accompanied with decreased blood plasma levels of corticosterone (primary glucocorticoid in rodents) and coupled to an E3 ubiquitin ligase Mdm2 targeted proteasomal degradation of GR, because genistein treatment could enhance the GR-Mdm2 interaction and the ubiquitination level of GR protein.	Corticosterone	96-110	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	32-34
24138934-5	2014	We saw that the baseline frequency of SWDs in Scn8a mutants correlates closely with the diurnal activity of the hypothalamic-pituitary-adrenal (HPA) axis, with a peak in seizure activity occurring at around the same time as the peak in corticosterone (1700-1900h).	Corticosterone	236-250	sodium voltage-gated channel alpha subunit 8	Homo sapiens	46-51
24319742-2	2013	Administration of glucocorticoid receptor blocker mifepristone to rats without diabetes was followed by a 1.9-fold increase in serum corticosterone concentration and a 1.2-fold increase in tyrosine aminotransferase activity in the liver in comparison with the baseline values.	Corticosterone	133-147	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	18-41
24064356-1	2013	Using the retrogradely transported immunotoxin, antidopamine beta-hydroxylase-saporin (DSAP), we showed previously that hindbrain catecholamine neurons innervating corticotropin-releasing hormone neurons in the paraventricular nucleus of the hypothalamus are required for glucoprivation-induced corticosterone secretion.	Corticosterone	295-309	corticotropin releasing hormone	Rattus norvegicus	164-195
24123181-5	2013	Significant increase in the rate of calcium-dependent exocytosis of ANP.emd was observed with the 100 nM and 1 muM corticosterone treatments for 3 h, which depended on the activation of the glucocorticoid receptor.	Corticosterone	115-129	latexin	Homo sapiens	111-114
24123181-8	2013	Corticosterone treatment also resulted in increased GFAP expression and F-actin rearrangements.	Corticosterone	0-14	glial fibrillary acidic protein	Homo sapiens	52-56
24123181-9	2013	FITC-Phalloidin immunostaining revealed increased formation of cross linked F-actin networks with the 100 nM and 1 muM corticosterone treatment.	Corticosterone	119-133	latexin	Homo sapiens	115-118
23774011-7	2013	While corticosterone inhibits CRH transcription in the PVH, stress-induced glucocorticoids stimulate CRH expression in the extended amygdala.	Corticosterone	6-20	corticotropin releasing hormone	Homo sapiens	30-33
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	15-29	nuclear receptor subfamily 3 group C member 2	Homo sapiens	121-123
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	15-29	nuclear receptor subfamily 3 group C member 1	Homo sapiens	133-156
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	15-29	nuclear receptor subfamily 3 group C member 1	Homo sapiens	158-160
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	31-35	nuclear receptor subfamily 3 group C member 2	Homo sapiens	93-119
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	31-35	nuclear receptor subfamily 3 group C member 2	Homo sapiens	121-123
25182773-2	2014	The actions of corticosterone (CORT) in the brain are mediated via two receptor systems: the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR).	Corticosterone	31-35	nuclear receptor subfamily 3 group C member 1	Homo sapiens	133-156
23891637-14	2013	Pearson"s analysis of data on D-32 showed that there was significant correlation of plasma corticosterone, amygdalar serotonin and hippocampal ratio of mineralocorticoid (MR)/glucocorticoid receptor (GR) with SRS-induced behavioral abnormalities.	Corticosterone	91-105	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	175-198
24028220-2	2013	In previous studies, central administration of NPW during the light phase increased food and water intake and elevated prolactin and corticosterone levels in conscious, unrestrained male rats.	Corticosterone	133-147	neuropeptide W	Rattus norvegicus	47-50
23911746-5	2013	We investigated the acute effects of the stress hormone corticosterone (CORT) on the social transmission of food preferences (STFP) in male and female mice.	Corticosterone	56-70	cortistatin	Mus musculus	72-76
24348341-0	2013	Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus.	Corticosterone	0-14	carbonic anhydrase 3	Rattus norvegicus	43-46
24348341-0	2013	Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	81-104
24348341-2	2013	Exposure to acute stress induces corticosterone (CORT) secretion from the adrenal cortex, resulting in rapid increase of CORT levels in plasma and the hippocampus.	Corticosterone	33-47	cortistatin	Rattus norvegicus	49-53
24348341-2	2013	Exposure to acute stress induces corticosterone (CORT) secretion from the adrenal cortex, resulting in rapid increase of CORT levels in plasma and the hippocampus.	Corticosterone	33-47	cortistatin	Rattus norvegicus	121-125
23876452-8	2013	Imbalance in receptor-mediated corticosterone actions was found to leave a genomic signature highlighting the role of master switches such as cAMP response element-binding protein and mammalian target of rapamycin to compromise health, and to promote vulnerability to disease.	Corticosterone	31-45	mechanistic target of rapamycin kinase	Homo sapiens	184-213
24563705-1	2013	We recently reported that prolonged exposure to the glucocorticoid receptor (GR) ligand corticosterone impairs decision-making that is dependent on the predictive relationship between an action and its outcome (Gourley et al.	Corticosterone	88-102	nuclear receptor subfamily 3 group C member 1	Homo sapiens	52-75
24563705-1	2013	We recently reported that prolonged exposure to the glucocorticoid receptor (GR) ligand corticosterone impairs decision-making that is dependent on the predictive relationship between an action and its outcome (Gourley et al.	Corticosterone	88-102	nuclear receptor subfamily 3 group C member 1	Homo sapiens	77-79
24061267-2	2013	As a regulator of glucocorticoid levels, type I isoform HSD11B1 is a bidirectional enzyme but acts predominantly as an oxidoreductase to yield active glucocorticoids, cortisol or corticosterone.	Corticosterone	179-193	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	56-63
24021706-5	2013	KO mice treated with LPS/D-GalN displayed a significant enhancement of plasma corticosterone, aspartate aminotransferase, and alanine aminotransferase levels compared to LPS/D-GalN treated WT mice at 12h after induction of sepsis.	Corticosterone	78-92	galanin and GMAP prepropeptide	Mus musculus	27-31
23928361-6	2013	Using primary culture of hippocampal neurons treated with oligomeric Abeta and corticosterone as model agents for AD and depression, respectively, we found significant changes in the pre-synaptic vesicle proteins synaptophysin and synaptotagmin.	Corticosterone	79-93	synaptophysin	Homo sapiens	213-226
24061267-2	2013	As a regulator of glucocorticoid levels, type I isoform HSD11B1 is a bidirectional enzyme but acts predominantly as an oxidoreductase to yield active glucocorticoids, cortisol or corticosterone.	Corticosterone	179-193	hydroxysteroid 17-beta dehydrogenase 6	Homo sapiens	119-133
24065704-3	2013	Immunoprecipitation of hypothalamic chromatin from intact or adrenalectomized rats subjected to either stress or corticosterone injections showed minor association of the proximal CRH promoter with the GR compared with that with phospho-CREB (pCREB).	Corticosterone	113-127	corticotropin releasing hormone	Rattus norvegicus	180-183
24065704-6	2013	In vitro, corticosterone pretreatment (30 minutes or 18 hours) only slightly inhibited basal and forskolin-stimulated CRH heteronuclear RNA in primary hypothalamic neuronal cultures and CRH promoter activity in hypothalamic 4B cells.	Corticosterone	10-24	corticotropin releasing hormone	Rattus norvegicus	118-121
24065704-6	2013	In vitro, corticosterone pretreatment (30 minutes or 18 hours) only slightly inhibited basal and forskolin-stimulated CRH heteronuclear RNA in primary hypothalamic neuronal cultures and CRH promoter activity in hypothalamic 4B cells.	Corticosterone	10-24	corticotropin releasing hormone	Rattus norvegicus	186-189
23937971-3	2013	Maternal corticosterone (CORT), released during prenatal stress, is a possible mediator of these effects.	Corticosterone	9-23	cortistatin	Rattus norvegicus	25-29
23942011-8	2013	Significant correlations between plasma levels of vasopressin and corticosterone and aggressive behavior were also found.	Corticosterone	66-80	arginine vasopressin	Rattus norvegicus	50-61
24089003-7	2013	RESULTS: TLR2 mice exhibited a lack of suppression and an attenuated increase in endogenous corticosterone production following hydrocortisone or LTA treatment, respectively.	Corticosterone	92-106	toll-like receptor 2	Mus musculus	9-13
24194694-10	2013	In these stress-challenged animals silencing CRF in the CeA significantly attenuated corticosterone responses to a subsequent behavioral stressor.	Corticosterone	85-99	CEA cell adhesion molecule 3	Homo sapiens	56-59
24048966-4	2013	In this study, we investigated whether male mice with a genetic predisposition for high-reactivity (HR), intermediate-reactivity (IR), or low-reactivity (LR) stress-induced corticosterone (CORT) secretion present different levels of free CORT and CORT-binding proteins, basally and in response to stressors of different intensity.	Corticosterone	173-187	cortistatin	Mus musculus	189-193
24167611-7	2013	After several trials 5-HTT-/- mice exhibited higher corticosterone concentrations compared with both other genotypes in both tests.	Corticosterone	52-66	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	21-26
24167611-8	2013	Corticosterone levels were highest in 5-HTT-/- mice tested in the WM indicating greater aversiveness of the WM and a greater stress sensitivity of 5-HTT deficient mice.	Corticosterone	0-14	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	38-43
24167611-8	2013	Corticosterone levels were highest in 5-HTT-/- mice tested in the WM indicating greater aversiveness of the WM and a greater stress sensitivity of 5-HTT deficient mice.	Corticosterone	0-14	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	147-152
24096962-3	2013	The cortisol/cortisone (F/E) ratio in humans and the corticosterone/11-dehydrocorticosterone (B/A) ratio in mice are markers of the activity of HSD11B2.	Corticosterone	53-67	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	144-151
24012698-7	2013	Stress also enhanced circulating corticosterone (CORT).	Corticosterone	33-47	cortistatin	Rattus norvegicus	49-53
23541378-6	2013	The impact of corticosterone (cort), estradiol (E2), and progesterone (P4) treatments on the expression of the genes Nr3c1, Ppid, and Fkbp5 was assessed in HT-22 hippocampal neurons.	Corticosterone	14-28	nuclear receptor subfamily 3 group C member 1	Homo sapiens	117-122
23541378-6	2013	The impact of corticosterone (cort), estradiol (E2), and progesterone (P4) treatments on the expression of the genes Nr3c1, Ppid, and Fkbp5 was assessed in HT-22 hippocampal neurons.	Corticosterone	14-28	FKBP prolyl isomerase 5	Homo sapiens	134-139
23541378-6	2013	The impact of corticosterone (cort), estradiol (E2), and progesterone (P4) treatments on the expression of the genes Nr3c1, Ppid, and Fkbp5 was assessed in HT-22 hippocampal neurons.	Corticosterone	14-18	nuclear receptor subfamily 3 group C member 1	Homo sapiens	117-122
23541378-6	2013	The impact of corticosterone (cort), estradiol (E2), and progesterone (P4) treatments on the expression of the genes Nr3c1, Ppid, and Fkbp5 was assessed in HT-22 hippocampal neurons.	Corticosterone	14-18	FKBP prolyl isomerase 5	Homo sapiens	134-139
23566924-6	2013	Rats who experienced the same duration of repeated restraint showed a significant decrease of plasma corticosterone (CORT) compared to the 10 min acute restraint group (habituation).	Corticosterone	101-115	cortistatin	Rattus norvegicus	117-121
24089339-6	2013	We exposed chick-rearing kittiwakes to a short-term (3-day) period of increased exogenous corticosterone (CORT), a hormone that is released during food shortages.	Corticosterone	90-104	CORT	Gallus gallus	106-110
23846420-6	2013	CCI increases corticosterone, which through its actions at the glucocorticoid receptor (GR), can trigger cellular adaptation.	Corticosterone	14-28	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	63-86
23846420-6	2013	CCI increases corticosterone, which through its actions at the glucocorticoid receptor (GR), can trigger cellular adaptation.	Corticosterone	14-28	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	88-90
23846420-12	2013	Our results suggest a role for altered PAG, GR-corticosterone interactions and their resultant cellular consequences in the expression of disabilities in a subpopulation of nerve-injured rats.	Corticosterone	47-61	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	44-46
23773309-10	2013	administration of IL-1beta significantly increased the plasma corticosterone level up to 60 min.	Corticosterone	62-76	interleukin 1 beta	Mus musculus	18-26
23832962-6	2013	This elevated 11beta-HSD1-derived corticosterone led to increased body weight gain and adiposity and produced marked insulin resistance.	Corticosterone	34-48	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	14-25
23932308-7	2013	The plasma corticosterone concentration was decreased by 1 and 2 mug of UCN II and UCN III and increased by 0.5 and 5 mug of UCN III.	Corticosterone	11-25	urocortin 2	Rattus norvegicus	72-78
24025224-7	2013	Treatment with endogenous (corticosterone) and synthetic (dexamethasone) glucocorticoids dose-dependently increased B2R mRNA levels in adrenomedullary-derived PC12 cells.	Corticosterone	27-41	bradykinin receptor B2	Rattus norvegicus	116-119
24025224-9	2013	In response to 1 exposure to IMO, the stress-triggered rise in plasma corticosterone and adrenomedullary B2R mRNA levels was attenuated in CRH-knockout mice and absent in pharmacologically adrenalectomized rats, indicating a requirement for glucocorticoids in the upregulation of B2R gene expression with stress.	Corticosterone	70-84	corticotropin releasing hormone	Mus musculus	139-142
23680895-0	2013	Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors.	Corticosterone	12-26	chemokine (C-X-C motif) ligand 12	Mus musculus	109-115
23932308-8	2013	The present results demonstrate that central administration of Ucn II and Ucn III modulate time-dependently and dose-dependently the amygdalar and the hypothalamic CRF concentration, and, directly or indirectly, the plasma corticosterone concentration.	Corticosterone	223-237	urocortin 2	Rattus norvegicus	63-69
24053666-8	2013	Sox2-Cre:Errbeta+/lox and Sox2-Cre:Errbetalox/lox mice treated with the Errbeta and Errgamma agonist DY131 demonstrated increased corticotropin-releasing hormone (Crh) expression in the paraventricular nucleus of the hypothalamus, although corticosterone levels were not affected.	Corticosterone	240-254	SRY (sex determining region Y)-box 2	Mus musculus	0-4
24640766-3	2013	PEP Inhibitor also prevented the increase of serum corticosterone level in the models of "behavioral despair" and anxiety-depressive state, but not in the model of MPTP-induced depression-like syndrome.	Corticosterone	51-65	prolyl endopeptidase	Rattus norvegicus	0-3
24303173-9	2013	The increase in blood pressure correlated significantly with a decline in the apparent activity of 11beta-hydroxysteroid dehydrogenase 2 and an increase of 11beta-hydroxysteroid dehydrogenase 1, when urinary corticosterone metabolites were considered.	Corticosterone	208-222	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	156-193
24035000-2	2013	Because of potentially deleterious effects of chronic stress, physiological measurements of stress hormones (in birds, corticosterone (CORT)) are often used to determine the consequences of natural or human-induced change.	Corticosterone	119-133	cortistatin	Homo sapiens	135-139
23806722-13	2013	bLRs" increase in positive affect after chronic EC was coupled with significant positive correlations between corticosterone levels and c-fos mRNA in the accumbens.	Corticosterone	110-124	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	136-141
23806722-14	2013	Conversely, a decline in the rate of positive calls in bHRs after chronic EC was associated with a negative correlation between corticosterone and accumbens c-fos mRNA.	Corticosterone	128-142	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	157-162
23896051-5	2013	However, an elevated level of corticosterone was found in the MTHFR deficient-NS female, exemplifying enhanced sensitivity to NS.	Corticosterone	30-44	methylenetetrahydrofolate reductase	Mus musculus	62-67
24066159-12	2013	Compared to WT and antibody treated mice, TLR2(-/-) mice exhibited reduced IL-6 (both P &lt; 0.05) but not IL-1beta levels and increased corticosterone plasma concentrations (both P &lt; 0.05).	Corticosterone	137-151	toll-like receptor 2	Mus musculus	42-46
23884964-7	2013	Corticosterone-treated CB1-KO mice showed a lack of weight gain and of increase in hypothalamic and hepatic AMPK activity.	Corticosterone	0-14	cannabinoid receptor 1 (brain)	Mus musculus	23-26
23847298-7	2013	The expression of 11beta-HSD1 was increased by vitamin A deficiency in the hypothalamus (+62.5%) as in the hippocampus (+104.7%), which could lead to a higher production of corticosterone locally and contribute to alteration of the hippocampus.	Corticosterone	173-187	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	18-29
23872451-11	2013	These data indicate that, in the experimental model of adrenalectomised rats implanted with corticosterone pellets, nicotine increases the function of 5-HT1A receptors of 5-HT DRN neurons.	Corticosterone	92-106	5-hydroxytryptamine receptor 1A	Rattus norvegicus	151-157
23856493-0	2013	Role of brain corticosterone and aldosterone in central angiotensin II-induced hypertension.	Corticosterone	14-28	angiotensinogen	Homo sapiens	56-70
24053666-6	2013	Sox2-Cre:Errbeta+/lox heterozygotes were obese, had increased Npy and Agrp gene expression in the arcuate nucleus of the hypothalamus, and secreted more corticosterone in response to stress.	Corticosterone	153-167	SRY (sex determining region Y)-box 2	Mus musculus	0-4
24053666-6	2013	Sox2-Cre:Errbeta+/lox heterozygotes were obese, had increased Npy and Agrp gene expression in the arcuate nucleus of the hypothalamus, and secreted more corticosterone in response to stress.	Corticosterone	153-167	estrogen related receptor, beta	Mus musculus	9-16
24053666-6	2013	Sox2-Cre:Errbeta+/lox heterozygotes were obese, had increased Npy and Agrp gene expression in the arcuate nucleus of the hypothalamus, and secreted more corticosterone in response to stress.	Corticosterone	153-167	lysyl oxidase	Mus musculus	18-21
23891657-4	2013	Here we show that corticosterone ("Cort") in feathers grown during the breeding season reflects reproductive effort in two Antarctic seabird species (giant petrels, Macronectes spp.).	Corticosterone	18-32	CORT	Gallus gallus	35-39
23694905-12	2013	Inhibition of OCT3-mediated transport by corticosterone may represent a mechanism by which acute stress alters dopaminergic neurotransmission in the amygdala, leading to alterations in fear and anxiety-like behavior.	Corticosterone	41-55	solute carrier family 22 member 3	Rattus norvegicus	14-18
23856493-4	2013	Intracerebroventricular Ang II, at 2.5 and 12.5 ng/min, increased hypothalamic aldosterone and corticosterone, as well as plasma aldosterone and corticosterone without affecting plasma Ang II levels.	Corticosterone	95-109	angiotensinogen	Homo sapiens	24-30
23856493-4	2013	Intracerebroventricular Ang II, at 2.5 and 12.5 ng/min, increased hypothalamic aldosterone and corticosterone, as well as plasma aldosterone and corticosterone without affecting plasma Ang II levels.	Corticosterone	145-159	angiotensinogen	Homo sapiens	24-30
23825033-5	2013	The current studies demonstrate that estrogen regulates AMPK activation in caudal hindbrain A2 noradrenergic neurons during pharmacological replication of energy shortage in this area of the brain, and that this sensor is involved in neural regulation of glucostasis, in part, through control of corticosterone secretion.	Corticosterone	296-310	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	56-60
23089634-4	2013	GR(dim)-LPS mice exhibited elevated and prolonged levels of plasma corticosterone (CORT), interleukin (IL)-6 and IL-10 (but not plasma tumor necrosis factor-alpha (TNFalpha)), enhanced early expression of brain TNFalpha, IL-1beta and IL-6 mRNA levels, and impaired later central TNFalpha mRNA expression.	Corticosterone	67-81	nuclear receptor subfamily 3, group C, member 1	Mus musculus	0-2
23643750-2	2013	Stress exposure leads to the secretion of glucocorticoids (cortisol in the human; corticosterone (CORT) in the rodent).	Corticosterone	82-96	cortistatin	Homo sapiens	98-102
23721787-3	2013	We detected that repeated exposure to CP55940 enhanced the prolactin and corticosterone neuroendocrine responses mediated by 5-HT2A receptors and increased the membrane-associated levels of 5-HT2A receptors in PVN.	Corticosterone	73-87	5-hydroxytryptamine receptor 2A	Rattus norvegicus	125-131
23818519-3	2013	These changes induce rapid cytoskeletal rearrangements (increased PSD-95 co-clustering) within the post-synaptic density; these events are accompanied by increased surface NMDA receptor expression, reflecting corticosterone-induced inhibition of NMDA receptor endocytosis.	Corticosterone	209-223	discs large MAGUK scaffold protein 4	Homo sapiens	66-72
23552018-5	2013	Using electrophysiological techniques, we investigated effects of stress and the stress hormone corticosterone (Cort) on NMDAR-mediated synaptic function and long-term depression (LTD) in hippocampal CA1 slices from these adolescent (aged 28-39 d) male offspring.	Corticosterone	96-110	cortistatin	Rattus norvegicus	112-116
23552018-5	2013	Using electrophysiological techniques, we investigated effects of stress and the stress hormone corticosterone (Cort) on NMDAR-mediated synaptic function and long-term depression (LTD) in hippocampal CA1 slices from these adolescent (aged 28-39 d) male offspring.	Corticosterone	96-110	carbonic anhydrase 1	Rattus norvegicus	200-203
23818519-5	2013	The observed up-regulation of ERK1/2 (downstream of NMDA receptor signaling) together with the fact that c-Abl integrates cytoplasmic and nuclear functions introduces a potential mechanism through which rapid signaling initiated at the plasma membrane may eventually determine the long term integrated response to corticosterone by impacting on the transcriptional machinery that is regulated by classical, nuclear mineralocorticoid, and glucocorticoid receptors.	Corticosterone	314-328	mitogen-activated protein kinase 3	Homo sapiens	30-36
23818519-5	2013	The observed up-regulation of ERK1/2 (downstream of NMDA receptor signaling) together with the fact that c-Abl integrates cytoplasmic and nuclear functions introduces a potential mechanism through which rapid signaling initiated at the plasma membrane may eventually determine the long term integrated response to corticosterone by impacting on the transcriptional machinery that is regulated by classical, nuclear mineralocorticoid, and glucocorticoid receptors.	Corticosterone	314-328	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	105-110
23966905-9	2013	In situ hybridization analyses suggest that select mRNAs are regulated by chronic corticosterone exposure specifically in astroctyes based on (1) similar general expression patterns between corticosterone-treated and vehicle-treated animals and (2) similar expression patterns to the pan-astrocyte marker Aldh1l1.	Corticosterone	82-96	aldehyde dehydrogenase 1 family, member L1	Mus musculus	305-312
23839258-5	2013	The data showed that 35 days of corticosterone exposure led to a decrease in spine density in CA1, concomitant with the onset of depression.	Corticosterone	32-46	carbonic anhydrase 1	Mus musculus	94-97
25206514-5	2013	Therefore, Shuyusan-containing serum appears to protect SH-SY5Y cells against corticosterone-induced impairment by adjusting the expression of apoptosis-associated proteins and brain-derived neurotrophic factor.	Corticosterone	78-92	brain derived neurotrophic factor	Homo sapiens	177-210
23727402-2	2013	Adult male rats were given systemic injections of corticosterone (CORT; 3mg/kg) immediately after training in a contextual fear conditioning (CFC) task and the percentage of time spent freezing in the CFC context was recorded 24h after training.	Corticosterone	50-64	cortistatin	Rattus norvegicus	66-70
23630299-9	2013	SSTR2a treatment enhanced low-glucose-stimulated glucagon and corticosterone secretion to normal levels in diabetic rats.	Corticosterone	62-76	somatostatin receptor 2	Rattus norvegicus	0-5
23608736-0	2013	The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus.	Corticosterone	59-73	reelin	Rattus norvegicus	149-155
23736296-3	2013	Here, we adrenalectomized male F344 rats at 15 months of age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid receptor-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1.	Corticosterone	106-120	cortistatin	Rattus norvegicus	122-126
23736296-3	2013	Here, we adrenalectomized male F344 rats at 15 months of age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid receptor-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1.	Corticosterone	106-120	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	167-190
23736296-3	2013	Here, we adrenalectomized male F344 rats at 15 months of age, maintained them for 3 months with implanted corticosterone (CORT) pellets producing low or intermediate (glucocorticoid receptor-activating) blood levels of CORT, and performed microarray/pathway analyses in hippocampal CA1.	Corticosterone	106-120	cortistatin	Rattus norvegicus	219-223
23794137-1	2013	The aim of this study was to investigate tumor necrosis factor alpha (TNF-alpha)- and noradrenaline (NE)-stimulated lipolysis in retroperitoneal (RWAT) and epididymal (EAT) white adipose tissue as a means of understanding how low-protein, high-carbohydrate (LPHC) diet-fed rats maintain their lipid storage in a catabolic environment (marked by increases in serum TNF-alpha and corticosterone and sympathetic flux to RWAT and EAT), as previously observed.	Corticosterone	378-392	tumor necrosis factor	Rattus norvegicus	41-68
23794137-1	2013	The aim of this study was to investigate tumor necrosis factor alpha (TNF-alpha)- and noradrenaline (NE)-stimulated lipolysis in retroperitoneal (RWAT) and epididymal (EAT) white adipose tissue as a means of understanding how low-protein, high-carbohydrate (LPHC) diet-fed rats maintain their lipid storage in a catabolic environment (marked by increases in serum TNF-alpha and corticosterone and sympathetic flux to RWAT and EAT), as previously observed.	Corticosterone	378-392	tumor necrosis factor	Rattus norvegicus	70-79
23608736-2	2013	This hypothesis is based on previous work in which we showed that repeated exposure to the stress hormone corticosterone, which increases depression-like behavior in rodents, also decreases the number of reelin+ cells in specific regions of the hippocampus and decreases hippocampal neurogenesis.	Corticosterone	106-120	reelin	Rattus norvegicus	204-210
23608736-3	2013	In addition, we have found that heterozygous reeler mice, which express approximately 50% of normal brain levels of reelin, are more susceptible to the depressogenic effects of corticosterone than their wild-type counterparts.	Corticosterone	177-191	reelin	Mus musculus	116-122
23608736-6	2013	We found that corticosterone-treated rats showed gradual increases in depression-like behavior over time, which were accompanied by similarly gradual decreases in reelin expression in the dentate subgranular zone and decreases in the number and dendritic complexity of surviving immature dentate granule cells.	Corticosterone	14-28	reelin	Rattus norvegicus	163-169
23694845-11	2013	Furthermore, TSS (25 mug/ml) markedly ameliorated up-regulation of Bax and down-regulation of Bcl-2 in corticosterone-induced PC12 cells.	Corticosterone	103-117	BCL2, apoptosis regulator	Rattus norvegicus	94-99
23834778-4	2013	Our results confirm that MIF-knockout (MIF-KO) mice possess higher levels of circulating corticosterone, but lower expression of glucocorticoid receptor in pancreatic islets, liver and adipose tissue to the one observed in wild type (WT) mice.	Corticosterone	89-103	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	25-28
23834778-4	2013	Our results confirm that MIF-knockout (MIF-KO) mice possess higher levels of circulating corticosterone, but lower expression of glucocorticoid receptor in pancreatic islets, liver and adipose tissue to the one observed in wild type (WT) mice.	Corticosterone	89-103	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	39-42
23499785-0	2013	A possible mechanism contributing to the synergistic action of vasotocin (VT) and corticotropin-releasing hormone (CRH) receptors on corticosterone release in birds.	Corticosterone	133-147	corticotropin releasing hormone	Homo sapiens	82-113
23864669-11	2013	Expression of organic cation transporter 3, a corticosterone-sensitive uptake2 transporter, was detected on NAc neurons.	Corticosterone	46-60	solute carrier family 22 member 3	Rattus norvegicus	14-42
23434929-1	2013	Selective antagonism of somatostatin receptor type 2 (SSTR2) normalizes glucagon and corticosterone responses to hypoglycemic clamp in diabetic rats.	Corticosterone	85-99	somatostatin receptor 2	Rattus norvegicus	24-52
23434929-1	2013	Selective antagonism of somatostatin receptor type 2 (SSTR2) normalizes glucagon and corticosterone responses to hypoglycemic clamp in diabetic rats.	Corticosterone	85-99	somatostatin receptor 2	Rattus norvegicus	54-59
23434929-9	2013	Corticosterone response deteriorated in the placebo-treated rats on Expt-D2 but increased twofold in the SSTR2a group.	Corticosterone	0-14	somatostatin receptor 2	Rattus norvegicus	105-110
23434929-11	2013	Thus, SSTR2 antagonism after recurrent hypoglycemia improves the glucagon and corticosterone responses and largely ameliorates insulin-induced hypoglycemia in diabetic rats.	Corticosterone	78-92	somatostatin receptor 2	Rattus norvegicus	6-11
23499785-0	2013	A possible mechanism contributing to the synergistic action of vasotocin (VT) and corticotropin-releasing hormone (CRH) receptors on corticosterone release in birds.	Corticosterone	133-147	corticotropin releasing hormone	Homo sapiens	115-118
23499785-2	2013	When AVT and CRH are administered together in vitro or in vivo, levels of adrenocorticotropic hormone (ACTH) or plasma corticosterone (CORT) are released, respectively, in a synergistic manner.	Corticosterone	119-133	corticotropin releasing hormone	Homo sapiens	13-16
23499785-2	2013	When AVT and CRH are administered together in vitro or in vivo, levels of adrenocorticotropic hormone (ACTH) or plasma corticosterone (CORT) are released, respectively, in a synergistic manner.	Corticosterone	135-139	corticotropin releasing hormone	Homo sapiens	13-16
23474014-4	2013	We targeted the rapid and delayed time domain by injecting corticosterone (CORT, 1 mg/kg, s.c.) at 30 min (rapid) or 180 min (delayed) respectively prior to behavioural testing, during the final 3 days of the behavioural paradigm.	Corticosterone	59-73	cortistatin	Rattus norvegicus	75-79
23633532-8	2013	Lipogenic gene expression was decreased, whereas lipolytic and beta-oxidative gene expression increased in corticosterone (CORT)- and 11DHC-treated wild-type mice and CORT (but not 11DHC)-treated 11beta-HSD1(-/-) mice.	Corticosterone	107-121	cortistatin	Mus musculus	123-127
23599356-6	2013	Corticosterone decreased the expression of apolipoprotein B and apolipoprotein VLDL-II in the liver.	Corticosterone	0-14	apolipoprotein B	Gallus gallus	43-86
23064802-6	2013	Moreover, blockade of nNOS activity in the hippocampus leads to decreased corticosterone (CORT, glucocorticoids in rodents) concentration in the plasma and reduced corticotrophin-releasing factor expression in the hypothalamus.	Corticosterone	74-88	nitric oxide synthase 1, neuronal	Mus musculus	22-26
23064802-6	2013	Moreover, blockade of nNOS activity in the hippocampus leads to decreased corticosterone (CORT, glucocorticoids in rodents) concentration in the plasma and reduced corticotrophin-releasing factor expression in the hypothalamus.	Corticosterone	90-94	nitric oxide synthase 1, neuronal	Mus musculus	22-26
23640176-0	2013	A rapid facilitation of acid-sensing ion channels current by corticosterone in cultured hippocampal neurons.	Corticosterone	61-75	acid sensing ion channel subunit 1	Homo sapiens	24-49
23194475-5	2013	Increased levels of Abeta in the hippocampus of corticosterone-treated mice were counteracted by propranolol treatment, purportedly through an increased IDE expression.	Corticosterone	48-62	insulin degrading enzyme	Mus musculus	153-156
23194475-6	2013	Chronic corticosterone treatment induced responses characteristic of insulin resistance, as increased peripheral insulin levels, decreased activation of the insulin receptor (pIR) and decreased associated intracellular pathways (pAkt).	Corticosterone	8-22	insulin receptor	Mus musculus	157-173
23194475-6	2013	Chronic corticosterone treatment induced responses characteristic of insulin resistance, as increased peripheral insulin levels, decreased activation of the insulin receptor (pIR) and decreased associated intracellular pathways (pAkt).	Corticosterone	8-22	pirin	Mus musculus	175-178
23194475-9	2013	One of the main kinases involved in tau phosphorylation, glycogen synthase kinase 3beta (GSK3beta), which is inactivated by phosphorylation by pAkt, was found to be decreased after corticosterone and increased after propranolol treatment.	Corticosterone	181-195	glycogen synthase kinase 3 beta	Mus musculus	57-87
23194475-9	2013	One of the main kinases involved in tau phosphorylation, glycogen synthase kinase 3beta (GSK3beta), which is inactivated by phosphorylation by pAkt, was found to be decreased after corticosterone and increased after propranolol treatment.	Corticosterone	181-195	glycogen synthase kinase 3 beta	Mus musculus	89-97
23494228-8	2013	RESULTS: Corticosterone decreased the phosphorylation of Akt and FoxO3a and led to the nuclear localization of FoxO3a and the apoptosis of PC12 cells.	Corticosterone	9-23	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
23494228-8	2013	RESULTS: Corticosterone decreased the phosphorylation of Akt and FoxO3a and led to the nuclear localization of FoxO3a and the apoptosis of PC12 cells.	Corticosterone	9-23	forkhead box O3	Rattus norvegicus	65-71
23494228-8	2013	RESULTS: Corticosterone decreased the phosphorylation of Akt and FoxO3a and led to the nuclear localization of FoxO3a and the apoptosis of PC12 cells.	Corticosterone	9-23	forkhead box O3	Rattus norvegicus	111-117
23494228-11	2013	Western blot analyses showed that venlafaxine induced the phosphorylation of Akt and FoxO3a by the PI3K/Akt pathway and reversed the reduction of the phosphorylated Akt and FoxO3a, and the nuclear translocation of Foxo3a induced by corticosterone.	Corticosterone	232-246	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
23494228-11	2013	Western blot analyses showed that venlafaxine induced the phosphorylation of Akt and FoxO3a by the PI3K/Akt pathway and reversed the reduction of the phosphorylated Akt and FoxO3a, and the nuclear translocation of Foxo3a induced by corticosterone.	Corticosterone	232-246	forkhead box O3	Rattus norvegicus	85-91
23494228-12	2013	CONCLUSIONS: Venlafaxine protects PC12 cells against corticosterone-induced cell death by modulating the activity of the PI3K/Akt/FoxO3a pathway.	Corticosterone	53-67	AKT serine/threonine kinase 1	Rattus norvegicus	126-129
23494228-12	2013	CONCLUSIONS: Venlafaxine protects PC12 cells against corticosterone-induced cell death by modulating the activity of the PI3K/Akt/FoxO3a pathway.	Corticosterone	53-67	forkhead box O3	Rattus norvegicus	130-136
23603525-8	2013	However, the higher responsiveness of aged rats to ghrelin-mediated increase in lipid metabolites was accompanied by an increase in adrenocorticotropic hormone and corticosterone levels.	Corticosterone	164-178	ghrelin and obestatin prepropeptide	Rattus norvegicus	51-58
23640176-9	2013	In addition, CORT application further resulted in a significant enhancement of ASIC1a current in the presence of phorbol 12-myristate 13-acetate (0.5 muM) or bryostatin1 (1 muM), which are both protein kinase C (PKC) agonists.	Corticosterone	13-17	latexin	Homo sapiens	150-153
23640176-9	2013	In addition, CORT application further resulted in a significant enhancement of ASIC1a current in the presence of phorbol 12-myristate 13-acetate (0.5 muM) or bryostatin1 (1 muM), which are both protein kinase C (PKC) agonists.	Corticosterone	13-17	latexin	Homo sapiens	173-176
23658016-7	2013	In addition, apoA-I-KO mice had less LPS clearance, reduced corticosterone generation, and impaired leukocyte recruitment in sepsis.	Corticosterone	60-74	apolipoprotein A-I	Mus musculus	13-19
23572539-1	2013	Within the anterior pituitary gland, glucocorticoids such as corticosterone (CORT) provide negative feedback to inhibit adrenocorticotropic hormone secretion and act to regulate production of other hormones including growth hormone (GH).	Corticosterone	61-75	CORT	Gallus gallus	77-81
23572539-1	2013	Within the anterior pituitary gland, glucocorticoids such as corticosterone (CORT) provide negative feedback to inhibit adrenocorticotropic hormone secretion and act to regulate production of other hormones including growth hormone (GH).	Corticosterone	61-75	growth hormone	Gallus gallus	217-231
23572539-1	2013	Within the anterior pituitary gland, glucocorticoids such as corticosterone (CORT) provide negative feedback to inhibit adrenocorticotropic hormone secretion and act to regulate production of other hormones including growth hormone (GH).	Corticosterone	61-75	growth hormone	Gallus gallus	233-235
24130987-1	2013	We studied the effects of injections of 5-HT1A-agonist buspirone to pregnant rats before stress exposure on corticosterone level in the dynamics of stress response to inflammatory-induced pain in 7-day-old offspring.	Corticosterone	108-122	5-hydroxytryptamine receptor 1A	Rattus norvegicus	40-46
23090754-12	2013	With corticosterone (CT), an endogenous form of corticosteroids in rodents, 0.1-2.5 muM was found to induce GILZ in H9c2(2-1) cells.	Corticosterone	5-19	TSC22 domain family, member 3	Rattus norvegicus	108-112
23090754-12	2013	With corticosterone (CT), an endogenous form of corticosteroids in rodents, 0.1-2.5 muM was found to induce GILZ in H9c2(2-1) cells.	Corticosterone	21-23	TSC22 domain family, member 3	Rattus norvegicus	108-112
23044404-0	2013	Mineralocorticoid receptor antagonist spironolactone prevents chronic corticosterone induced depression-like behavior.	Corticosterone	70-84	nuclear receptor subfamily 3, group C, member 2	Mus musculus	0-26
23631927-3	2013	Iron deficient pregnant dams and their pups displayed elevated corticosterone which, in turn, differentially affected glucocorticoid receptor (GR) expression in the CA1 and the dentate gyrus.	Corticosterone	63-77	nuclear receptor subfamily 3 group C member 1	Homo sapiens	118-141
23631927-3	2013	Iron deficient pregnant dams and their pups displayed elevated corticosterone which, in turn, differentially affected glucocorticoid receptor (GR) expression in the CA1 and the dentate gyrus.	Corticosterone	63-77	nuclear receptor subfamily 3 group C member 1	Homo sapiens	143-145
23631927-3	2013	Iron deficient pregnant dams and their pups displayed elevated corticosterone which, in turn, differentially affected glucocorticoid receptor (GR) expression in the CA1 and the dentate gyrus.	Corticosterone	63-77	carbonic anhydrase 1	Homo sapiens	165-168
23631927-4	2013	Brain Derived Neurotrophic Factor (BDNF) was reduced in the hippocampi of pups following elevated corticosterone levels.	Corticosterone	98-112	brain derived neurotrophic factor	Homo sapiens	0-33
23631927-4	2013	Brain Derived Neurotrophic Factor (BDNF) was reduced in the hippocampi of pups following elevated corticosterone levels.	Corticosterone	98-112	brain derived neurotrophic factor	Homo sapiens	35-39
23169006-6	2013	In corticosterone-treated H19-7 cells, the knock down of TRPC1 no longer blocks thapsigargin-stimulated Ca(2+) entry suggesting that the subtype of SOCs expressed in H19-7 cells is altered by corticosterone treatment.	Corticosterone	3-17	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	57-62
23169006-6	2013	In corticosterone-treated H19-7 cells, the knock down of TRPC1 no longer blocks thapsigargin-stimulated Ca(2+) entry suggesting that the subtype of SOCs expressed in H19-7 cells is altered by corticosterone treatment.	Corticosterone	192-206	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	57-62
23169006-8	2013	Consistent with this finding is the observation that corticosterone treatment of H19-7 cells increases the expression of the I(CRAC) channel subunit Orai1.	Corticosterone	53-67	ORAI calcium release-activated calcium modulator 1	Rattus norvegicus	149-154
23044404-4	2013	The aim of this study is to explore if chronic corticosterone administration would induce depression-like behavior and affect the expression and function of hippocampal MR and GR, in addition to assess whether manipulation of corticosteroid receptors would modulate depressive behaviors.	Corticosterone	47-61	nuclear receptor subfamily 3, group C, member 2	Mus musculus	169-171
23044404-4	2013	The aim of this study is to explore if chronic corticosterone administration would induce depression-like behavior and affect the expression and function of hippocampal MR and GR, in addition to assess whether manipulation of corticosteroid receptors would modulate depressive behaviors.	Corticosterone	47-61	nuclear receptor subfamily 3, group C, member 1	Mus musculus	176-178
23044404-6	2013	The results show that chronic corticosterone-treated animals displayed an increased immobility time in a forced-swimming test, decreased preference to sucrose solution and novel object recognition performance, and enhanced hippocampal serotonin but decreased MR expression in both hippocampus and hypothalamus.	Corticosterone	30-44	nuclear receptor subfamily 3, group C, member 2	Mus musculus	259-261
23389997-10	2013	This chronic social defeat induced upregulation of DBH expression was mediated through corticosterone and corticosteroid receptors, with possible interference from antidepressants.	Corticosterone	87-101	dopamine beta-hydroxylase	Rattus norvegicus	51-54
23044404-9	2013	In conclusion, we demonstrate that chronic corticosterone treatment triggers several depression-like behaviors, and in parallel, down-regulates MR expression in the hippocampus and hypothalamus.	Corticosterone	43-57	nuclear receptor subfamily 3, group C, member 2	Mus musculus	144-146
23044404-10	2013	Administration of an MR antagonist confers an anti-depressant effect in chronic corticosterone-treated animals.	Corticosterone	80-94	nuclear receptor subfamily 3, group C, member 2	Mus musculus	21-23
23653479-7	2013	In vivo, TR4 overexpression promotes murine corticotroph tumor growth as well as enhances ACTH and corticosterone production, whereas TR4 knockdown decreases circulating ACTH and corticosterone levels in mice harboring ACTH-secreting tumors.	Corticosterone	99-113	nuclear receptor subfamily 2, group C, member 2	Mus musculus	9-12
23089211-4	2013	Vimentin null mice were found to have decreased ACTH-stimulated corticosterone levels, and decreased progesterone levels in females, but normal hCG-stimulated testosterone levels in males.	Corticosterone	64-78	vimentin	Mus musculus	0-8
23512810-1	2013	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) is involved in the pathogenesis of type 2 diabetes by generating active glucocorticoids (cortisol and corticosterone) that are strong inhibitors of angiogenesis.	Corticosterone	159-173	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	44-55
23653479-7	2013	In vivo, TR4 overexpression promotes murine corticotroph tumor growth as well as enhances ACTH and corticosterone production, whereas TR4 knockdown decreases circulating ACTH and corticosterone levels in mice harboring ACTH-secreting tumors.	Corticosterone	179-193	nuclear receptor subfamily 2, group C, member 2	Mus musculus	134-137
23524097-8	2013	Both doses of erythropoietin (500 and 1000 IU/kg) pretreatment and co-treatment, (i) significantly increased the habituation memory and percentage alteration which are indicative of the cognitive improvement, (ii) attenuated the Aroclor 1254 induced rise in acetylcholinesterase activity, corticosterone, triglycerides and total cholesterol, (iii) increased the glutamate and antioxidant enzyme levels.	Corticosterone	289-303	erythropoietin	Mus musculus	14-28
23613579-7	2013	In contrast, it lacks agonistic effects on the expression of CRH in the central amygdala and antagonizes GR-mediated reduction in hippocampal neurogenesis after chronic corticosterone exposure.	Corticosterone	169-183	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	105-107
23458502-3	2013	Both an unselective COX inhibitor (indomethacin) and a selective COX-2 inhibitor (NS-398) significantly attenuated the increase of serum corticosterone levels after LPS and restraint stresses, but not after 2DG injection.	Corticosterone	137-151	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	65-70
23305081-9	2013	Further, SHSY5Y neuroblastoma cells treated with corticosterone showed increased BACE1, pTau and pJNK1 expression.	Corticosterone	49-63	beta-secretase 1	Homo sapiens	81-86
23850672-5	2013	Activation of TLR2 inhibits chronic stress-reduced phosphorylation of c-Jun N-terminal kinase (JNK) and diminishes chronic stress-induced up-regulation of corticosterone production.	Corticosterone	155-169	toll like receptor 2	Homo sapiens	14-18
23578952-8	2013	These findings show that monoacylglycerol lipase inhibition dramatically increases basal levels of corticosterone.	Corticosterone	99-113	monoglyceride lipase	Mus musculus	25-48
22850435-5	2013	After corticosterone exposure for 24 h, HT-22 cells showed a concentration-dependent increase in mRNA levels for PDE2 subtypes, PDE2A1 and 2A3, as well as for the total PDE2A protein expression.	Corticosterone	6-20	phosphodiesterase 2A, cGMP-stimulated	Mus musculus	128-133
22850435-9	2013	Furthermore, Bay 60-7550 reversed corticosterone-induced down-regulation of brain-derived neurotrophic factor protein levels 24 h after corticosterone exposure.	Corticosterone	34-48	brain derived neurotrophic factor	Mus musculus	76-109
22850435-9	2013	Furthermore, Bay 60-7550 reversed corticosterone-induced down-regulation of brain-derived neurotrophic factor protein levels 24 h after corticosterone exposure.	Corticosterone	136-150	brain derived neurotrophic factor	Mus musculus	76-109
22709945-0	2013	Neonatal exposure to low dose corticosterone persistently modulates hippocampal mineralocorticoid receptor expression and improves locomotor/exploratory behaviour in a mouse model of Rett syndrome.	Corticosterone	30-44	nuclear receptor subfamily 3, group C, member 2	Mus musculus	80-106
22709945-6	2013	In line with previous reports, when fully symptomatic, MeCP2-308 mice showed a reduction in the regular nocturnal hyperactivity in the home-cage and increased anxiety-like behaviours and plasma corticosterone (CORT) levels in response to restraint stress.	Corticosterone	194-208	methyl CpG binding protein 2	Mus musculus	55-60
22709945-6	2013	In line with previous reports, when fully symptomatic, MeCP2-308 mice showed a reduction in the regular nocturnal hyperactivity in the home-cage and increased anxiety-like behaviours and plasma corticosterone (CORT) levels in response to restraint stress.	Corticosterone	210-214	methyl CpG binding protein 2	Mus musculus	55-60
23062748-0	2013	PACAP-deficient mice show attenuated corticosterone secretion and fail to develop depressive behavior during chronic social defeat stress.	Corticosterone	37-51	adenylate cyclase activating polypeptide 1	Mus musculus	0-5
23035922-0	2013	Inhibition of immobilization stress-induced anorexia, behavioral deficits, and plasma corticosterone secretion by injected leptin in rats.	Corticosterone	86-100	leptin	Rattus norvegicus	123-129
23035922-8	2013	Animals injected with leptin at a dose of 0.1 mg/kg, but not at dose of 0.5 mg/kg, exhibited a marginal increase in plasma corticosterone.	Corticosterone	123-137	leptin	Rattus norvegicus	22-28
23035922-9	2013	Immobilization-induced increases of plasma corticosterone were reversed by leptin injected at doses of 0.1 or 0.5 mg/kg.	Corticosterone	43-57	leptin	Rattus norvegicus	75-81
23333402-4	2013	ACTH-treatment increased basal serum corticosterone levels, with an additional increase induced by the FST.	Corticosterone	37-51	pro-opiomelanocortin-alpha	Mus musculus	0-4
23489747-4	2013	In addition, MSP partially suppressed cytokine and corticosterone secretion in response to endotoxin administration.	Corticosterone	51-65	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	13-16
23578952-0	2013	Monoacylglycerol lipase inhibition-induced changes in plasma corticosterone levels, anxiety and locomotor activity in male CD1 mice.	Corticosterone	61-75	monoglyceride lipase	Mus musculus	0-23
23578952-3	2013	Here we studied the effects of the recently developed monoacylglycerol lipase inhibitor JZL184 on basal and stress-induced corticosterone levels in male CD1 mice, and found that this compound dramatically increased basal levels without affecting stress responses.	Corticosterone	123-137	monoglyceride lipase	Mus musculus	54-77
23181759-3	2013	Corticosterone treatment induced an increased expression of stress-activated c-Jun N-terminal kinase (JNK) in the hippocampus, accompanied by decreases in glycogen synthase kinase 3beta, increases in pTau levels and increased neuronal cell death (caspase-3 activity).	Corticosterone	0-14	caspase 3	Homo sapiens	247-256
23280813-5	2013	As inhibitors of rOCT2, corticosterone, verapamil, and cimetidine can inhibit jatrorrhizine uptake in rat kidney slices and rOCT2-MDCK cells.	Corticosterone	24-38	solute carrier family 22 member 2	Rattus norvegicus	124-129
23280813-7	2013	Coadministration with 20 mg/kg corticosterone, a selective inhibitor of rOCT2, reduced the jatrorrhizine concentration in the cortex and medulla in the in vivo experiment.	Corticosterone	31-45	solute carrier family 22 member 2	Rattus norvegicus	72-77
23276607-8	2013	Altered plasma corticosterone responses to ACTH injections were observed over the treatment course.	Corticosterone	15-29	proopiomelanocortin	Homo sapiens	43-47
23276607-10	2013	ACTH administration initially enhanced plasma corticosterone levels, however, these normalised to levels consistent with control animals by day 14.	Corticosterone	46-60	proopiomelanocortin	Homo sapiens	0-4
23237312-8	2013	Ank3+/- mice also exhibited elevated serum corticosterone, suggesting that reduced Ank3 expression is associated with elevated stress reactivity.	Corticosterone	43-57	ankyrin 3, epithelial	Mus musculus	0-4
23321399-6	2013	ICV injection of cVIP caused increased plasma corticosterone concentration and decreased diencephalic mRNA expression of CRH, CRH receptor-2 (CRH-R2) and urocortin 3 (UCN-3, which has high affinity for CRH-R2).	Corticosterone	46-60	urocortin 3	Gallus gallus	167-172
23181759-0	2013	Mineralocorticoid receptor activation induces insulin resistance through c-Jun N-terminal kinases in response to chronic corticosterone: cognitive implications.	Corticosterone	121-135	insulin	Homo sapiens	46-53
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Corticosterone	99-113	insulin	Homo sapiens	257-264
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Corticosterone	99-113	insulin	Homo sapiens	321-328
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Corticosterone	99-113	insulin receptor	Homo sapiens	394-410
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Corticosterone	158-172	insulin	Homo sapiens	257-264
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Corticosterone	158-172	insulin	Homo sapiens	321-328
23181759-2	2013	In the present study, in vivo experiments using a non-invasive method of chronic administration of corticosterone in drinking water demonstrated that chronic corticosterone administration led to cognitive impairment in the novel object recognition test and insulin resistance, as shown by significant increases in plasma insulin levels and the homeostatic model assessment index, and decreased insulin receptor phosphorylation.	Corticosterone	158-172	insulin receptor	Homo sapiens	394-410
23181759-3	2013	Corticosterone treatment induced an increased expression of stress-activated c-Jun N-terminal kinase (JNK) in the hippocampus, accompanied by decreases in glycogen synthase kinase 3beta, increases in pTau levels and increased neuronal cell death (caspase-3 activity).	Corticosterone	0-14	mitogen-activated protein kinase 8	Homo sapiens	77-100
23181759-3	2013	Corticosterone treatment induced an increased expression of stress-activated c-Jun N-terminal kinase (JNK) in the hippocampus, accompanied by decreases in glycogen synthase kinase 3beta, increases in pTau levels and increased neuronal cell death (caspase-3 activity).	Corticosterone	0-14	mitogen-activated protein kinase 8	Homo sapiens	102-105
23320836-6	2013	Dexamethasone (DEX) or corticosterone greatly increased Ucn2 mRNA levels in PC12 cells in a dose-dependent manner.	Corticosterone	23-37	urocortin 2	Rattus norvegicus	56-60
23320836-9	2013	In CRH-knockout mice, where the IMO-induced rise in corticosterone was attenuated, the response of IMO on Ucn2, as well as CRHR2 mRNAs was absent.	Corticosterone	52-66	corticotropin releasing hormone	Mus musculus	3-6
23517603-12	2013	Corticosterone and noradrenaline, at pathophysiological levels, increased expression and secretion of IL-6 in B16-F10 cells in vitro.	Corticosterone	0-14	interleukin 6	Mus musculus	102-106
23517603-13	2013	Corticosterone- and noradrenaline-induced transcriptional up-regulation of IL-6 gene involves changes in the DNA binding activity of nuclear factor-kappaB, cAMP response element-binding protein, activator protein-1, and nuclear factor for IL-6.	Corticosterone	0-14	interleukin 6	Mus musculus	75-79
23517603-13	2013	Corticosterone- and noradrenaline-induced transcriptional up-regulation of IL-6 gene involves changes in the DNA binding activity of nuclear factor-kappaB, cAMP response element-binding protein, activator protein-1, and nuclear factor for IL-6.	Corticosterone	0-14	interleukin 6	Mus musculus	239-243
23255172-1	2013	Stress activates the hypothalamic-pituitary-adrenocortical axis to promote the release of corticosterone (CORT), which consequently suppresses pathogenic stimulation of the immune system.	Corticosterone	90-104	cortistatin	Mus musculus	106-110
23333161-0	2013	Adrenalectomy and corticosterone replacement differentially alter CA3 dendritic morphology and new cell survival in the adult rat hippocampus.	Corticosterone	18-32	carbonic anhydrase 3	Rattus norvegicus	66-69
22591911-0	2013	Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment.	Corticosterone	19-33	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	37-42
22591911-0	2013	Chronic effects of corticosterone on GIRK1-3 subunits and 5-HT1A receptor expression in rat brain and their reversal by concurrent fluoxetine treatment.	Corticosterone	19-33	5-hydroxytryptamine receptor 1A	Rattus norvegicus	58-64
22591911-2	2013	Animal studies indicate that 5-HT1A receptor expression may be reduced by long-term administration of corticosterone.	Corticosterone	102-116	5-hydroxytryptamine receptor 1A	Rattus norvegicus	29-35
22591911-11	2013	Finally, chronic corticosterone treatment produced an increase on the mRNA coding for the GIRK2 subunit in several hypothalamic and thalamic areas, which was reversed by fluoxetine.	Corticosterone	17-31	potassium inwardly-rectifying channel, subfamily J, member 6	Rattus norvegicus	90-95
22591911-13	2013	These data are relevant for a better understanding of the differential regulation of pre- and postsynaptic 5-HT1A receptors by corticosterone flattened rhythm.	Corticosterone	127-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	107-113
23142231-8	2013	The aberrant increase of plasma corticosterone in neonates increased the plasma concentration of norepinephrine, nerve growth factor in the gastric fundus muscularis externae, brain-derived neurotrophic factor in the thoracic dorsal root ganglia and spinal cord, and down-regulated K(v)1.1 messenger RNA in thoracic dorsal root ganglia without affecting the expression of K(v)1.4, Na(v)1.8, TrpA1, TrpV1, or P2X3 in FD-like rats.	Corticosterone	32-46	brain-derived neurotrophic factor	Rattus norvegicus	176-209
23142231-8	2013	The aberrant increase of plasma corticosterone in neonates increased the plasma concentration of norepinephrine, nerve growth factor in the gastric fundus muscularis externae, brain-derived neurotrophic factor in the thoracic dorsal root ganglia and spinal cord, and down-regulated K(v)1.1 messenger RNA in thoracic dorsal root ganglia without affecting the expression of K(v)1.4, Na(v)1.8, TrpA1, TrpV1, or P2X3 in FD-like rats.	Corticosterone	32-46	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	381-389
23142231-8	2013	The aberrant increase of plasma corticosterone in neonates increased the plasma concentration of norepinephrine, nerve growth factor in the gastric fundus muscularis externae, brain-derived neurotrophic factor in the thoracic dorsal root ganglia and spinal cord, and down-regulated K(v)1.1 messenger RNA in thoracic dorsal root ganglia without affecting the expression of K(v)1.4, Na(v)1.8, TrpA1, TrpV1, or P2X3 in FD-like rats.	Corticosterone	32-46	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	391-396
23142231-8	2013	The aberrant increase of plasma corticosterone in neonates increased the plasma concentration of norepinephrine, nerve growth factor in the gastric fundus muscularis externae, brain-derived neurotrophic factor in the thoracic dorsal root ganglia and spinal cord, and down-regulated K(v)1.1 messenger RNA in thoracic dorsal root ganglia without affecting the expression of K(v)1.4, Na(v)1.8, TrpA1, TrpV1, or P2X3 in FD-like rats.	Corticosterone	32-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	398-403
23142231-8	2013	The aberrant increase of plasma corticosterone in neonates increased the plasma concentration of norepinephrine, nerve growth factor in the gastric fundus muscularis externae, brain-derived neurotrophic factor in the thoracic dorsal root ganglia and spinal cord, and down-regulated K(v)1.1 messenger RNA in thoracic dorsal root ganglia without affecting the expression of K(v)1.4, Na(v)1.8, TrpA1, TrpV1, or P2X3 in FD-like rats.	Corticosterone	32-46	purinergic receptor P2X 3	Rattus norvegicus	408-412
23333161-2	2013	Stress and elevated corticosterone levels have been shown to decrease hippocampal neurogenesis and decrease the complexity of CA3 pyramidal neurons.	Corticosterone	20-34	carbonic anhydrase 3	Rattus norvegicus	126-129
23333161-4	2013	Therefore, the aim of the present study was to determine how low to moderately elevated circulating corticosterone levels affect dendritic morphology of CA3 pyramidal cells and hippocampal neurogenesis in adult male rats.	Corticosterone	100-114	carbonic anhydrase 3	Rattus norvegicus	153-156
23333161-8	2013	This work shows that circulating levels of corticosterone differentially affect plasticity in the CA3 region and the dentate gyrus.	Corticosterone	43-57	carbonic anhydrase 3	Rattus norvegicus	98-101
23211515-3	2013	We combine these methods with measurements of body composition in corticotropin-releasing hormone (CRH)-transgenic (Tg)(+) mice that have chronically elevated, endogenously produced corticosterone and a phenotype that closely mimics Cushing"s disease in humans.	Corticosterone	182-196	corticotropin releasing hormone	Mus musculus	66-97
22371048-0	2013	Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation.	Corticosterone	91-105	adenosine A2a receptor	Rattus norvegicus	0-24
23407965-6	2013	Using mice with reduced gene dosage of p190rhogap, a cytoskeletal regulatory protein localized to dendritic spines, we next isolated structural correlates of both behavioral vulnerability (spine elimination) and resilience (spine proliferation) to corticosterone within the orbital cortex.	Corticosterone	248-262	Rho GTPase activating protein 35	Mus musculus	39-49
23211515-3	2013	We combine these methods with measurements of body composition in corticotropin-releasing hormone (CRH)-transgenic (Tg)(+) mice that have chronically elevated, endogenously produced corticosterone and a phenotype that closely mimics Cushing"s disease in humans.	Corticosterone	182-196	corticotropin releasing hormone	Mus musculus	99-102
23098799-0	2013	Effects of chronic treatment with corticosterone and imipramine on fos immunoreactivity and adult hippocampal neurogenesis.	Corticosterone	34-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-70
23164951-5	2013	Indeed, the current studies demonstrate that exposure of mice to the immunosuppressive GC, corticosterone (CORT), over the entire course of the primary immune response limits activation of endogenous Tag-specific T(CD8).	Corticosterone	91-105	cortistatin	Mus musculus	107-111
23142160-6	2013	If prolactin and corticosterone mediate the same functional response to a stressor and are the proxies of the same response, we predict that corticosterone and prolactin stress responses (1) will be modulated according to the same factors; (2) will affect reproductive performances in the same way; and, (3) of course, will be correlated.	Corticosterone	17-31	prolactin	Gallus gallus	160-169
23142160-6	2013	If prolactin and corticosterone mediate the same functional response to a stressor and are the proxies of the same response, we predict that corticosterone and prolactin stress responses (1) will be modulated according to the same factors; (2) will affect reproductive performances in the same way; and, (3) of course, will be correlated.	Corticosterone	141-155	prolactin	Gallus gallus	3-12
23104420-5	2013	AngII increased the corticosterone response after ACTH infusions, clearly indicating the key role of the adrenals for mediating stress reactions.	Corticosterone	20-34	angiotensinogen	Rattus norvegicus	0-5
23104420-8	2013	During OGTT, AngII increased glucose and corticosterone responses in shamOZR, whereas insulin was slightly diminished.	Corticosterone	41-55	angiotensinogen	Rattus norvegicus	13-18
22176700-0	2013	Melanocortin-4 receptor in the medial amygdala regulates emotional stress-induced anxiety-like behaviour, anorexia and corticosterone secretion.	Corticosterone	119-133	melanocortin 4 receptor	Homo sapiens	0-23
22176700-8	2013	Moreover, plasma corticosterone levels were increased by intra-MeA infusion of the MC4R agonist under non-stressed conditions and restraint stress-induced elevation of plasma corticosterone levels was attenuated by pretreatment with SHU 9119 in the MeA.	Corticosterone	17-31	melanocortin 4 receptor	Homo sapiens	83-87
22176700-8	2013	Moreover, plasma corticosterone levels were increased by intra-MeA infusion of the MC4R agonist under non-stressed conditions and restraint stress-induced elevation of plasma corticosterone levels was attenuated by pretreatment with SHU 9119 in the MeA.	Corticosterone	175-189	melanocortin 4 receptor	Homo sapiens	83-87
22243662-7	2013	Basal norepinephrine levels were elevated in the amygdala, whereas stress-induced ACTH and corticosterone responses were alleviated in P2rx7(-/-) mice.	Corticosterone	91-105	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	135-140
22935038-3	2013	To model these components in rats, we administered high corticosterone (CORT) postpartum, which increases immobility in the forced swim test (FST), and reduces maternal care, body weight and hippocampal cell proliferation in dams.	Corticosterone	56-70	cortistatin	Rattus norvegicus	72-76
22968818-4	2013	Reduction of gamma power was sensitive to corticosterone application and associated with a decrease in glucocorticoid and mineralocorticoid receptor mRNA expression across strata of the ventral hippocampal CA3.	Corticosterone	42-56	nuclear receptor subfamily 3, group C, member 2	Mus musculus	122-148
22968818-4	2013	Reduction of gamma power was sensitive to corticosterone application and associated with a decrease in glucocorticoid and mineralocorticoid receptor mRNA expression across strata of the ventral hippocampal CA3.	Corticosterone	42-56	carbonic anhydrase 3	Mus musculus	206-209
23179589-3	2013	CORT (0.01-10 muM) caused a rapid increase in [Ca(2+)]i with a dose-dependent manner in cultured dorsal spinal cord astrocytes.	Corticosterone	0-4	latexin	Homo sapiens	14-17
23098799-1	2013	In a previous study we showed that rats chronically treated with corticosterone (CORT) display anxiogenic behavior, evidenced by facilitation of avoidance responses in the elevated T-maze (ETM) model of anxiety.	Corticosterone	65-79	cortistatin	Rattus norvegicus	81-85
23363614-5	2013	Secreted interleukin 6 (IL-6) was measured by enzyme-linked immunosorbent assay (ELISA), and its regulation by tumor necrosis factor-alpha (TNF-alpha and corticosterone (the major glucocorticoid in rodents) measured relative to other mesenchymal cell populations.	Corticosterone	154-168	interleukin 6	Mus musculus	9-22
22983097-8	2013	Repeated treatment with amitriptyline (5 mg/kg, intraperitoneally; bid) subsequent to corticosterone exposure also prevented the corticosterone-induced deficits in rats.	Corticosterone	129-143	BH3 interacting domain death agonist	Rattus norvegicus	67-70
23363614-5	2013	Secreted interleukin 6 (IL-6) was measured by enzyme-linked immunosorbent assay (ELISA), and its regulation by tumor necrosis factor-alpha (TNF-alpha and corticosterone (the major glucocorticoid in rodents) measured relative to other mesenchymal cell populations.	Corticosterone	154-168	interleukin 6	Mus musculus	24-28
23032077-4	2013	In this mini-review, we introduce various cases of maternal separation in rodents and illustrate the alterations in HPA-axis activity by focusing on corticosterone (CORT), an end-product of the HPA-axis in rodents.	Corticosterone	149-163	cortistatin	Mus musculus	165-169
24054157-2	2013	PACAP modulates the hypothalamic-pituitary-adrenal (HPA) axis in response to acute psychogenic but not systemic stressors, through activation of corticotropin-releasing hormone (CRH) release to drive adrenal corticosterone (CORT) output.	Corticosterone	208-222	adenylate cyclase activating polypeptide 1	Homo sapiens	0-5
24054157-2	2013	PACAP modulates the hypothalamic-pituitary-adrenal (HPA) axis in response to acute psychogenic but not systemic stressors, through activation of corticotropin-releasing hormone (CRH) release to drive adrenal corticosterone (CORT) output.	Corticosterone	208-222	corticotropin releasing hormone	Homo sapiens	145-176
24054157-2	2013	PACAP modulates the hypothalamic-pituitary-adrenal (HPA) axis in response to acute psychogenic but not systemic stressors, through activation of corticotropin-releasing hormone (CRH) release to drive adrenal corticosterone (CORT) output.	Corticosterone	208-222	corticotropin releasing hormone	Homo sapiens	178-181
24054157-2	2013	PACAP modulates the hypothalamic-pituitary-adrenal (HPA) axis in response to acute psychogenic but not systemic stressors, through activation of corticotropin-releasing hormone (CRH) release to drive adrenal corticosterone (CORT) output.	Corticosterone	224-228	adenylate cyclase activating polypeptide 1	Homo sapiens	0-5
24054157-2	2013	PACAP modulates the hypothalamic-pituitary-adrenal (HPA) axis in response to acute psychogenic but not systemic stressors, through activation of corticotropin-releasing hormone (CRH) release to drive adrenal corticosterone (CORT) output.	Corticosterone	224-228	corticotropin releasing hormone	Homo sapiens	178-181
21821638-5	2013	The changes (increasing rates) in mitogen-induced IL-2 production from basal condition showed a negative correlation with serum corticosterone concentrations.	Corticosterone	128-142	interleukin 2	Rattus norvegicus	50-54
22834538-9	2013	The serum corticosterone level lost rhythmicity and showed a decreased daily level in CLOCK mutant mice compared with WT mice, supporting the exacerbating effect of CLOCK mutation on CHS.	Corticosterone	10-24	circadian locomotor output cycles kaput	Mus musculus	86-91
22834538-9	2013	The serum corticosterone level lost rhythmicity and showed a decreased daily level in CLOCK mutant mice compared with WT mice, supporting the exacerbating effect of CLOCK mutation on CHS.	Corticosterone	10-24	circadian locomotor output cycles kaput	Mus musculus	165-170
24397505-2	2013	This study aimed to evaluate a stress model induced by corticosterone (CORT) supplementation in the diet of broiler breeder hens.	Corticosterone	55-69	CORT	Gallus gallus	71-75
23324285-15	2013	In addition, the inhibitory effect of corticosterone on IL-6 and TNF-alpha in LPS-stimulated splenocyte cultures in vitro was diminished in the asthma-SDR group compared to the asthma group.	Corticosterone	38-52	interleukin 6	Mus musculus	56-60
23324285-15	2013	In addition, the inhibitory effect of corticosterone on IL-6 and TNF-alpha in LPS-stimulated splenocyte cultures in vitro was diminished in the asthma-SDR group compared to the asthma group.	Corticosterone	38-52	tumor necrosis factor	Mus musculus	65-74
23662148-3	2013	Results showed that usage of the high dose of corticosterone (CORT) injection or external factors could successfully establish the KYDS or ASS rat models, and the two models had similar changes in biological characterization, abnormal behaviors, dysfunction of hypothalamic-pituitary-target organ axes (HPTOA), and sympathetic/parasympathetic (S/P) nerve system but varied in different degrees.	Corticosterone	46-60	cortistatin	Rattus norvegicus	62-66
24194757-7	2013	Furthermore, blocking GR activity inhibited 150 nM corticosterone-enhanced chemotaxis and phagocytosis of macrophages.	Corticosterone	51-65	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	22-24
23509214-11	2013	The HO-1 inducer (i.e., hemin) significantly decreased catecholamines and corticosterone levels, and increased testosterone and LH levels.	Corticosterone	74-88	heme oxygenase 1	Rattus norvegicus	4-8
23485819-10	2013	In contrast GRK5 deficiency significantly inhibited sepsis-induced plasma corticosterone levels and the consequent thymocyte apoptosis in vivo.	Corticosterone	74-88	G protein-coupled receptor kinase 5	Mus musculus	12-16
23086675-7	2013	These enhanced corticosterone levels were associated with a significant reduction in fetal brain weights and a significant increase in TAp73 mRNA and p73 protein levels.	Corticosterone	15-29	tumor protein p73	Homo sapiens	137-140
23830631-2	2013	PrxIII is reversibly inactivated by H2O2 produced by cytochrome P450 11B1 (CYP11B1) in mitochondria during corticosterone synthesis in the adrenal gland of mice injected with adrenocorticotropic hormone (ACTH).	Corticosterone	107-121	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	53-73
23830631-2	2013	PrxIII is reversibly inactivated by H2O2 produced by cytochrome P450 11B1 (CYP11B1) in mitochondria during corticosterone synthesis in the adrenal gland of mice injected with adrenocorticotropic hormone (ACTH).	Corticosterone	107-121	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	75-82
23830631-2	2013	PrxIII is reversibly inactivated by H2O2 produced by cytochrome P450 11B1 (CYP11B1) in mitochondria during corticosterone synthesis in the adrenal gland of mice injected with adrenocorticotropic hormone (ACTH).	Corticosterone	107-121	pro-opiomelanocortin-alpha	Mus musculus	175-202
23202366-4	2013	Corticosterone values in SR-BI KO transplanted mice remained  50% lower (P&lt;0.001) as compared with wild-type transplanted mice, which coincided with adrenocortical lipid depletion.	Corticosterone	0-14	scavenger receptor class B, member 1	Mus musculus	25-30
24194757-8	2013	Meanwhile, after treatment with corticosterone (150 nM) for 1 h and 3 h, GR protein expression increased to 1.4- and 2.2-fold, respectively, compared to untreated macrophages.	Corticosterone	32-46	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	73-75
24194757-11	2013	These results demonstrate that low concentrations of corticosterone exert stimulatory effects on macrophage function in the absence of immune stimuli, and GR is at least partially responsible for these effects.	Corticosterone	53-67	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	155-157
23349944-4	2013	Here we show expression and activity of 11beta-HSD1, but not 11beta-HSD2, in mouse mast cells with 11beta-HSD activity only in the keto-reductase direction, regenerating active glucocorticoids (cortisol, corticosterone) from inert substrates (cortisone, 11-dehydrocorticosterone).	Corticosterone	204-218	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	40-51
22622901-10	2012	Circulating corticosterone plays a role in the circadian timing system and the misaligned corticosterone rhythm in the VPAC2 receptor knockout mice could be involved in their abnormal rhythms of physiology.	Corticosterone	12-26	vasoactive intestinal peptide receptor 2	Mus musculus	119-133
23110767-6	2012	Numerous mRNAs regulated by dexamethasone were also regulated by the natural ligand corticosterone; all of the mRNAs regulated &gt;=twofold by corticosterone were substantially attenuated by cotreatment with the glucocorticoid receptor antagonist RU486.	Corticosterone	84-98	nuclear receptor subfamily 3, group C, member 1	Mus musculus	212-235
23110767-6	2012	Numerous mRNAs regulated by dexamethasone were also regulated by the natural ligand corticosterone; all of the mRNAs regulated &gt;=twofold by corticosterone were substantially attenuated by cotreatment with the glucocorticoid receptor antagonist RU486.	Corticosterone	143-157	nuclear receptor subfamily 3, group C, member 1	Mus musculus	212-235
23026495-2	2012	We characterized plasma corticosterone (CORT) concentrations in P. californicus under baseline conditions across the diurnal cycle, in response to pharmacological manipulation of the HPA axis, and in response to a variety of stressors at different times of day.	Corticosterone	24-38	cortistatin	Mus musculus	40-44
23088831-1	2012	Stress leads to secretion of the adrenal steroid hormone corticosterone (CORT).	Corticosterone	57-71	cortistatin	Rattus norvegicus	73-77
22831701-0	2012	Intact catecholamine inputs to the forebrain are required for appropriate regulation of corticotrophin-releasing hormone and vasopressin gene expression by corticosterone in the rat paraventricular nucleus.	Corticosterone	156-170	arginine vasopressin	Rattus norvegicus	125-136
22831701-6	2012	To determine the contribution of these neurones to the long-term actions of corticosterone on CRH and vasopressin (AVP) gene expression in the PVH, we used an immunocytotoxin (a conjugate of the cytotoxin saporin and an antibody against dopamine-beta-hydroxylase) that specifically ablates adrenergic and noradrenergic neurones.	Corticosterone	76-90	corticotropin releasing hormone	Rattus norvegicus	94-97
22831701-6	2012	To determine the contribution of these neurones to the long-term actions of corticosterone on CRH and vasopressin (AVP) gene expression in the PVH, we used an immunocytotoxin (a conjugate of the cytotoxin saporin and an antibody against dopamine-beta-hydroxylase) that specifically ablates adrenergic and noradrenergic neurones.	Corticosterone	76-90	arginine vasopressin	Rattus norvegicus	102-113
22831701-8	2012	The ability of elevated levels of corticosterone to suppress Crh expression was abolished in animals lacking catecholaminergic innervation of the PVH.	Corticosterone	34-48	corticotropin releasing hormone	Rattus norvegicus	61-64
22831701-11	2012	Interactions between corticosterone and catecholaminergic projections to the hypothalamus therefore make significant contributions to the regulation of Crh and Avp expression.	Corticosterone	21-35	corticotropin releasing hormone	Rattus norvegicus	152-155
22831701-11	2012	Interactions between corticosterone and catecholaminergic projections to the hypothalamus therefore make significant contributions to the regulation of Crh and Avp expression.	Corticosterone	21-35	arginine vasopressin	Rattus norvegicus	160-163
23020797-5	2012	Corticosterone treatment reduced Npas4 expression in the frontal cortex and hippocampus, whereas adrenalectomy caused an increase in expression.	Corticosterone	0-14	neuronal PAS domain protein 4	Mus musculus	33-38
23224599-2	2012	Each GFAP-immunoreactive cell showed a hypertrophic appearance with well-developed thicker fibrous processes, and the number and the density of GFAP-immunoreactive cells were increased 4 weeks after adrenalectomy, whereas the changes were restored to the sham-control level with corticosterone replacement.	Corticosterone	279-293	glial fibrillary acidic protein	Rattus norvegicus	5-9
23224599-2	2012	Each GFAP-immunoreactive cell showed a hypertrophic appearance with well-developed thicker fibrous processes, and the number and the density of GFAP-immunoreactive cells were increased 4 weeks after adrenalectomy, whereas the changes were restored to the sham-control level with corticosterone replacement.	Corticosterone	279-293	glial fibrillary acidic protein	Rattus norvegicus	144-148
23224599-4	2012	The quantitative analysis clearly showed a significant increase in the number and the density of GFAP-immunoreactive cells in the adrenalectomy group; following corticosterone replacement, these increases were returned to the sham-control level.	Corticosterone	161-175	glial fibrillary acidic protein	Rattus norvegicus	97-101
22995443-0	2012	Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration.	Corticosterone	135-149	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	105-109
22995443-5	2012	on the behavior, brain-derived neurotrophic factor (BDNF) and its receptor (TrkB) in depression-like rats induced by exogenous administration of the stress hormone corticosterone (40mg/kg, s.c.).	Corticosterone	164-178	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	76-80
22995443-8	2012	CONCLUSION: These findings confirm that HCE produce an antidepressant-like effect in corticosterone-induced depression-like model of rats and this effect is at least partly mediated by BDNF-TrkB signaling in the frontal cortex and hippocampus.	Corticosterone	85-99	brain-derived neurotrophic factor	Rattus norvegicus	185-189
22995443-8	2012	CONCLUSION: These findings confirm that HCE produce an antidepressant-like effect in corticosterone-induced depression-like model of rats and this effect is at least partly mediated by BDNF-TrkB signaling in the frontal cortex and hippocampus.	Corticosterone	85-99	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	190-194
22622901-3	2012	Mice lacking the VPAC2 receptor display disrupted circadian rhythm of physiology and behaviour, and therefore, we using real-time RT-PCR quantified (1) the mRNAs for the clock genes Per1 and Bmal1 in the adrenal gland and SCN, (2) the adrenal Star mRNA and (3) the serum corticosterone concentration both during a light/dark (L/D) cycle and at constant darkness in wild type (WT) and VPAC2 receptor-deficient mice (VPAC2-KO).	Corticosterone	271-285	vasoactive intestinal peptide receptor 2	Mus musculus	17-22
22622901-8	2012	The loss of adrenal clock gene rhythm in the VPAC2 receptor knockout mice after transfer into constant darkness was accompanied by disappearance of rhythmicity in Star mRNA expression and serum corticosterone concentration.	Corticosterone	194-208	vasoactive intestinal peptide receptor 2	Mus musculus	45-59
23099464-1	2012	The glucocorticoid hormones corticosterone (CORT) and cortisol influence numerous physiological, morphological, and behavioral functions.	Corticosterone	28-42	cortistatin	Mus musculus	44-48
22503140-4	2012	Research in rodents has shown that the response of basolateral amygdala neurons to corticosterone is mediated by GR.	Corticosterone	83-97	nuclear receptor subfamily 3 group C member 1	Homo sapiens	113-115
22251167-4	2012	Furthermore, we compare plasma corticosterone (CORT) concentrations in samples obtained through the catheter 1 day after surgery with samples taken from trunk blood obtained under basal or acute stress conditions.	Corticosterone	31-45	cortistatin	Mus musculus	47-51
22940619-1	2012	AIMS: Corticosterone (CORT), which is often referred to as the stress hormone, is a well-known regulator of peripheral immune responses and also shows anti-inflammatory properties in the brain.	Corticosterone	6-20	cortistatin	Mus musculus	22-26
22643070-2	2012	FXR agonist GW4064 increased fasting plasma corticosterone levels (+45%; P&lt;0.01) in C57BL/6 mice, indicative of enhanced adrenal steroidogenesis.	Corticosterone	44-58	nuclear receptor subfamily 1, group H, member 4	Mus musculus	0-3
22643070-6	2012	In conclusion, we have shown that the FXR agonist GW4064 stimulates plasma corticosterone levels in C57BL/6 mice.	Corticosterone	75-89	nuclear receptor subfamily 1, group H, member 4	Mus musculus	38-41
22735575-2	2012	The current study examined two mouse strains selected for naturalistic variation of tissue regeneration after injury for resistance to the effects of chronic corticosterone (CORT) exposure on cell proliferation and neurotrophin mobilization.	Corticosterone	158-172	cortistatin	Mus musculus	174-178
22813995-1	2012	Previous studies have shown that a 2-week treatment with 40 mg/kg corticosterone (CORT) in rats suppresses hippocampal neurogenesis and decreases hippocampal brain-derived neurotrophic factor (BDNF) levels and impairs spatial learning, all of which could be counteracted by voluntary wheel running.	Corticosterone	66-80	cortistatin	Rattus norvegicus	82-86
22813995-1	2012	Previous studies have shown that a 2-week treatment with 40 mg/kg corticosterone (CORT) in rats suppresses hippocampal neurogenesis and decreases hippocampal brain-derived neurotrophic factor (BDNF) levels and impairs spatial learning, all of which could be counteracted by voluntary wheel running.	Corticosterone	66-80	brain-derived neurotrophic factor	Rattus norvegicus	158-191
22813995-1	2012	Previous studies have shown that a 2-week treatment with 40 mg/kg corticosterone (CORT) in rats suppresses hippocampal neurogenesis and decreases hippocampal brain-derived neurotrophic factor (BDNF) levels and impairs spatial learning, all of which could be counteracted by voluntary wheel running.	Corticosterone	66-80	brain-derived neurotrophic factor	Rattus norvegicus	193-197
24080898-4	2013	Single ICV injection of clusterin provoked neurohormonal changes seen under acute stress condition: increased plasma adrenocorticotropic hormone (ACTH), corticosterone, GH and prolactin levels and decreased LH and FSH levels.	Corticosterone	153-167	clusterin	Mus musculus	24-33
22641006-8	2012	At the same time, Fkbp52(+/-) mice also demonstrated signs of stress resilience in other behavioral and neuroendocrine aspects, such as reduced basal corticosterone levels and more active stress-coping behavior in the FST following CSDS.	Corticosterone	150-164	FK506 binding protein 4	Mus musculus	18-24
23069671-2	2012	Recently various stressors and stress-induced molecules such as corticotropin-releasing hormone (CRH) and corticosterone have been shown to inhibit Kiss1 expression in rat hypothalamus.	Corticosterone	106-120	KiSS-1 metastasis-suppressor	Rattus norvegicus	148-153
23190711-10	2012	By converting inactive 11-dehydrocorticosterone to active corticosterone, 11beta-HSD1 essentially modulates the coordinated action of GR and MR. Biphasic effects were observed for 11-dehydrocorticosterone and corticosterone, with an MR-dependent potentiation of IL-6 and tumor necrosis factor-alpha (TNF-alpha) expression and NF-kappaB activation at low/moderate concentrations and a GR-dependent suppression at high concentrations.	Corticosterone	33-47	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	74-85
23190711-10	2012	By converting inactive 11-dehydrocorticosterone to active corticosterone, 11beta-HSD1 essentially modulates the coordinated action of GR and MR. Biphasic effects were observed for 11-dehydrocorticosterone and corticosterone, with an MR-dependent potentiation of IL-6 and tumor necrosis factor-alpha (TNF-alpha) expression and NF-kappaB activation at low/moderate concentrations and a GR-dependent suppression at high concentrations.	Corticosterone	58-72	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	74-85
23190711-10	2012	By converting inactive 11-dehydrocorticosterone to active corticosterone, 11beta-HSD1 essentially modulates the coordinated action of GR and MR. Biphasic effects were observed for 11-dehydrocorticosterone and corticosterone, with an MR-dependent potentiation of IL-6 and tumor necrosis factor-alpha (TNF-alpha) expression and NF-kappaB activation at low/moderate concentrations and a GR-dependent suppression at high concentrations.	Corticosterone	58-72	interleukin 6	Mus musculus	262-266
23190711-10	2012	By converting inactive 11-dehydrocorticosterone to active corticosterone, 11beta-HSD1 essentially modulates the coordinated action of GR and MR. Biphasic effects were observed for 11-dehydrocorticosterone and corticosterone, with an MR-dependent potentiation of IL-6 and tumor necrosis factor-alpha (TNF-alpha) expression and NF-kappaB activation at low/moderate concentrations and a GR-dependent suppression at high concentrations.	Corticosterone	58-72	tumor necrosis factor	Mus musculus	271-298
23190711-10	2012	By converting inactive 11-dehydrocorticosterone to active corticosterone, 11beta-HSD1 essentially modulates the coordinated action of GR and MR. Biphasic effects were observed for 11-dehydrocorticosterone and corticosterone, with an MR-dependent potentiation of IL-6 and tumor necrosis factor-alpha (TNF-alpha) expression and NF-kappaB activation at low/moderate concentrations and a GR-dependent suppression at high concentrations.	Corticosterone	58-72	tumor necrosis factor	Mus musculus	300-309
22995443-0	2012	Ethanol extracts from Hemerocallis citrina attenuate the decreases of brain-derived neurotrophic factor, TrkB levels in rat induced by corticosterone administration.	Corticosterone	135-149	brain-derived neurotrophic factor	Rattus norvegicus	70-103
22931956-8	2012	The stress-dependent effects on RCT rate and peroxisome proliferator-activated receptor-alpha gene expression were fully mimicked by administration of the stress hormone corticosterone (CORT) to nonstressed mice, and they were blocked by the inhibition of CORT synthesis in stressed mice.	Corticosterone	170-184	peroxisome proliferator activated receptor alpha	Mus musculus	45-93
22931956-8	2012	The stress-dependent effects on RCT rate and peroxisome proliferator-activated receptor-alpha gene expression were fully mimicked by administration of the stress hormone corticosterone (CORT) to nonstressed mice, and they were blocked by the inhibition of CORT synthesis in stressed mice.	Corticosterone	170-184	cortistatin	Mus musculus	186-190
22931956-8	2012	The stress-dependent effects on RCT rate and peroxisome proliferator-activated receptor-alpha gene expression were fully mimicked by administration of the stress hormone corticosterone (CORT) to nonstressed mice, and they were blocked by the inhibition of CORT synthesis in stressed mice.	Corticosterone	170-184	cortistatin	Mus musculus	256-260
22962255-4	2012	Injection of corticosterone (CORT) in postnatal d 6 and 30 mice increased Klf9 mRNA and heteronuclear RNA by 1 h in the hippocampal region.	Corticosterone	13-27	Kruppel-like factor 9	Mus musculus	74-78
22962255-4	2012	Injection of corticosterone (CORT) in postnatal d 6 and 30 mice increased Klf9 mRNA and heteronuclear RNA by 1 h in the hippocampal region.	Corticosterone	29-33	Kruppel-like factor 9	Mus musculus	74-78
23246684-3	2012	RESULTS: 5alpha reductases convert testosterone, progesterone, deoxycorticosterone, aldosterone and corticosterone into their respective 5alpha-dihydro-derivatives, which serve as substrates for 3alpha-hydroxysteroid dehydrogenase enzymes.	Corticosterone	68-82	aldo-keto reductase family 1 member C3	Homo sapiens	195-230
23060860-7	2012	It evokes corticosterone release by activating corticotropin-releasing hormone-containing neurons in the hypothalamic paraventricular nucleus.	Corticosterone	10-24	corticotropin releasing hormone	Mus musculus	47-78
22992651-6	2012	However, CRF-GABA(A)alpha1 KO increased anxiety-like behavior and impaired extinction of conditioned fear, coincident with an increase in plasma corticosterone concentration.	Corticosterone	145-159	gamma-aminobutyric acid (GABA) A receptor, subunit alpha 1	Mus musculus	13-26
22814115-2	2012	Previously, we demonstrated that the stress hormone corticosterone (CORT) localized to the central nucleus of the amygdala (CeA) induces anxiety-like behavior and increases the sensitivity to visceral or somatic stimuli in rats.	Corticosterone	52-66	cortistatin	Rattus norvegicus	68-72
22814115-2	2012	Previously, we demonstrated that the stress hormone corticosterone (CORT) localized to the central nucleus of the amygdala (CeA) induces anxiety-like behavior and increases the sensitivity to visceral or somatic stimuli in rats.	Corticosterone	52-66	carcinoembryonic antigen gene family 4	Rattus norvegicus	124-127
22962254-3	2012	Cyp11a1null embryos have appreciable although lower amounts of circulating corticosterone, the major mouse glucocorticoid, suggesting that transplacental corticosterone is a major source of corticosterone in fetal circulation.	Corticosterone	75-89	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	0-7
22962254-3	2012	Cyp11a1null embryos have appreciable although lower amounts of circulating corticosterone, the major mouse glucocorticoid, suggesting that transplacental corticosterone is a major source of corticosterone in fetal circulation.	Corticosterone	154-168	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	0-7
22962254-3	2012	Cyp11a1null embryos have appreciable although lower amounts of circulating corticosterone, the major mouse glucocorticoid, suggesting that transplacental corticosterone is a major source of corticosterone in fetal circulation.	Corticosterone	154-168	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	0-7
22536780-4	2012	Complexity of pathophysiological role of MR derives from the presence of circulating glucocorticoids at higher concentrations than aldosterone and the equal affinity of the MR for aldosterone, cortisol and corticosterone.	Corticosterone	206-220	nuclear receptor subfamily 3 group C member 2	Homo sapiens	41-43
22536780-4	2012	Complexity of pathophysiological role of MR derives from the presence of circulating glucocorticoids at higher concentrations than aldosterone and the equal affinity of the MR for aldosterone, cortisol and corticosterone.	Corticosterone	206-220	nuclear receptor subfamily 3 group C member 2	Homo sapiens	173-175
22622901-10	2012	Circulating corticosterone plays a role in the circadian timing system and the misaligned corticosterone rhythm in the VPAC2 receptor knockout mice could be involved in their abnormal rhythms of physiology.	Corticosterone	90-104	vasoactive intestinal peptide receptor 2	Mus musculus	119-133
22734681-7	2012	CB1R-KO mice had higher basal and chronic stress-induced adrenocorticotrophin and corticosterone levels and were more anxious on the elevated plus-maze versus WT.	Corticosterone	82-96	cannabinoid receptor 1 (brain)	Mus musculus	0-4
22538126-12	2012	Furthermore, the ratio of plasma aldosterone level to corticosterone was significantly decreased by immunization with BMP-6-KLH.	Corticosterone	54-68	bone morphogenetic protein 6	Rattus norvegicus	118-123
22226488-1	2012	Glucocorticoids (GC)--corticosterone (CORT) in rodents and cortisol in primates--are stress-induced hormones secreted by adrenal glands that interact with the hypothalamic pituitary axis.	Corticosterone	22-36	cortistatin	Rattus norvegicus	38-42
22521145-6	2012	Ghr-/- mice exhibited a lower corticosterone response after stress, suggesting dysfunctional glucocorticoid negative feedback in the absence of ghrelin.	Corticosterone	30-44	growth hormone receptor	Mus musculus	0-3
22521145-8	2012	Adrenocorticotropic hormone replacement elevated plasma corticosterone in ghr-/-, compared with WT mice, indicating increased adrenal sensitivity.	Corticosterone	56-70	pro-opiomelanocortin-alpha	Mus musculus	0-27
22521145-8	2012	Adrenocorticotropic hormone replacement elevated plasma corticosterone in ghr-/-, compared with WT mice, indicating increased adrenal sensitivity.	Corticosterone	56-70	growth hormone receptor	Mus musculus	74-77
22572034-2	2012	Spurred on by a seemingly paradoxical observation in which even a modest increase in corticosterone (CORT), caused by a single vehicle injection before stress, could dampen the delayed effects of stress, we hypothesized a protective role for glucocorticoids against stress.	Corticosterone	85-99	cortistatin	Rattus norvegicus	101-105
22922341-9	2012	Moreover, emodin (3 mumol/L) partly reversed the impaired insulin-stimulated glucose uptake and adiponectin secretion induced by 11-dehydrocorticosterone but not those induced by corticosterone.	Corticosterone	139-153	adiponectin, C1Q and collagen domain containing	Mus musculus	96-107
22631614-3	2012	The CpG7 site of the BACE promoter was significantly hypomethylated in MS, and corticosterone levels negatively correlated to the methylation status of CpG7.	Corticosterone	79-93	beta-secretase 1	Rattus norvegicus	21-25
22631614-5	2012	In SHSY-5Y neuroblastoma cells, corticosterone induced a rapid increase in BACE expression that was abolished by specific inhibiton of JNK activation or by spironolactone, a mineralocorticoid receptor antagonist, but not by mifepristone, a glucocorticoid receptor antagonist.	Corticosterone	32-46	beta-secretase 1	Homo sapiens	75-79
22631614-5	2012	In SHSY-5Y neuroblastoma cells, corticosterone induced a rapid increase in BACE expression that was abolished by specific inhibiton of JNK activation or by spironolactone, a mineralocorticoid receptor antagonist, but not by mifepristone, a glucocorticoid receptor antagonist.	Corticosterone	32-46	mitogen-activated protein kinase 8	Homo sapiens	135-138
22631614-7	2012	Mice chronically treated with corticosterone showed increased BACE and pJNK expression.	Corticosterone	30-44	beta-site APP cleaving enzyme 1	Mus musculus	62-66
22631614-9	2012	It is suggested that increased corticosterone levels associated to stress lead to increase BACE transcription both through epigenetic mechanisms and activation of JNK.	Corticosterone	31-45	beta-secretase 1	Rattus norvegicus	91-95
22631614-9	2012	It is suggested that increased corticosterone levels associated to stress lead to increase BACE transcription both through epigenetic mechanisms and activation of JNK.	Corticosterone	31-45	mitogen-activated protein kinase 8	Rattus norvegicus	163-166
22270486-8	2012	The serum corticosterone (CORT) concentration was increased in rats exposed to HH condition and this elevated CORT concentration was blocked after administration of naproxen in HH condition.	Corticosterone	10-24	cortistatin	Rattus norvegicus	26-30
22270486-8	2012	The serum corticosterone (CORT) concentration was increased in rats exposed to HH condition and this elevated CORT concentration was blocked after administration of naproxen in HH condition.	Corticosterone	10-24	cortistatin	Rattus norvegicus	110-114
22732081-1	2012	Corticosterone (CORT) levels in seabirds fluctuate across breeding stages and in different foraging conditions.	Corticosterone	0-14	CORT	Gallus gallus	16-20
22404240-0	2012	A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress.	Corticosterone	67-81	neuropeptide Y	Mus musculus	11-25
23214269-6	2012	Corticosteroid binding globulin (CBG) concentration differ significantly between high and low tolerant groups of rats resulting in significant changes in circulating free corticosterone that in turn may be responsible for individual differences in hypoxic gasping time.	Corticosterone	171-185	serpin family A member 6	Rattus norvegicus	0-31
23214269-6	2012	Corticosteroid binding globulin (CBG) concentration differ significantly between high and low tolerant groups of rats resulting in significant changes in circulating free corticosterone that in turn may be responsible for individual differences in hypoxic gasping time.	Corticosterone	171-185	serpin family A member 6	Rattus norvegicus	33-36
22921957-4	2012	Therefore, we studied the relation between fearfulness in an Open Field (OF) test at six weeks of age and plasma-corticosterone (CORT) levels after a 5-min Manual Restraint test (MR) at 33 weeks of age, and assessed behavior in the home pen.	Corticosterone	113-127	CORT	Gallus gallus	129-133
22777941-9	2012	Aldosterone was modulated by dietary sodium in both genotypes, and salt sensitivity in Hsd11b2(+/-) mice was associated with increased plasma corticosterone levels.	Corticosterone	142-156	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	87-94
22404240-11	2012	AR male NPY(-/-) mice had higher levels of corticosterone than male WT mice; whilst in AR WT mice, after peripheral Y(1) and Y(2) receptor antagonism in males, and Y(2) antagonism in females, corticosterone was significantly elevated.	Corticosterone	43-57	neuropeptide Y	Mus musculus	8-11
22404240-13	2012	Furthermore, NPY inhibits GI motility through Y(2) receptors and corticosterone release via peripheral Y(1) and Y(2) receptors.	Corticosterone	65-79	neuropeptide Y	Mus musculus	13-16
22659252-6	2012	The IL-12-reducing effects of wet-cage exposure, and of corticosterone and epinephrine administration, were significantly greater in males than in females, although females exhibited greater total corticosterone levels following stress.	Corticosterone	197-211	interleukin 12B	Rattus norvegicus	4-9
22554475-1	2012	The present study was conducted to explore the effects of corticosterone (CORT) on the regulation of appetite-associated genes in laying hens.	Corticosterone	58-72	CORT	Gallus gallus	74-78
22659252-4	2012	The findings indicated that plasma IL-12 levels were significantly reduced by social confrontation, wet-cage exposure, surgery, and the administration of corticosterone, epinephrine, or prostaglandin-E(2).	Corticosterone	154-168	interleukin 12B	Rattus norvegicus	35-40
22673661-3	2012	There is also evidence that prolactin can work either inversely or additively with corticosterone to achieve this.	Corticosterone	83-97	prolactin	Gallus gallus	28-37
22585831-0	2012	Fructose-induced hypothalamic AMPK activation stimulates hepatic PEPCK and gluconeogenesis due to increased corticosterone levels.	Corticosterone	108-122	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	30-34
22585831-8	2012	We also found that fructose increased corticosterone levels through a mechanism that is dependent on hypothalamic AMPK activation.	Corticosterone	38-52	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	114-118
22585831-10	2012	Altogether the data presented herein support the hypothesis that fructose-induced hypothalamic AMPK activation stimulates hepatic gluconeogenesis by increasing corticosterone levels.	Corticosterone	160-174	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	95-99
22673661-4	2012	Here we test the hypothesis that endogenous corticosterone plays a key physiological role in the control of foraging behavior and parental care, using a combination of exogenous corticosterone treatment, time-depth telemetry, and physiological sampling of female macaroni penguins (Eudyptes chrysolophus) during the brood-guard period of chick rearing, while simultaneously monitoring patterns of prolactin secretion.	Corticosterone	44-58	prolactin	Gallus gallus	397-406
22335772-9	2012	Furthermore, Rg1 up-regulated the BDNF signalling pathway in the hippocampus and down-regulated serum corticosterone level during the CMS procedure.	Corticosterone	102-116	protein phosphatase 1, regulatory subunit 3A	Mus musculus	13-16
22339976-9	2012	Abcb1a/1b (-/-) mice showed significantly decreased brain corticosterone levels and elevated glucocorticoid receptor expression.	Corticosterone	58-72	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	0-6
22527858-9	2012	It was also confirmed by in vivo tests using the vasopressin-deficient Brattleboro pup as a model organism, where corticosterone levels may rise without adrenocorticotropin level changes.	Corticosterone	114-128	arginine vasopressin	Rattus norvegicus	49-60
22555437-11	2012	Liver-specific deletion of 11beta-HSD1 reduces corticosterone regeneration and may be important for setting aspects of HPA axis tone, without impacting upon urinary steroid metabolite profile.	Corticosterone	47-61	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	27-38
22808907-3	2012	In addition, we recently reported that the global deletion of the Homer 1 proteins in mice leads to a conspicuous endocrine phenotype linked to hypertrophy of the adrenal cortex, elevated basal and/or adrenocorticotropic hormone-induced corticosterone and aldosterone release in vitro and in vivo, as well as a drastic increase in the adrenocorticotropic hormone receptor mRNA in the adrenocortical cells.	Corticosterone	237-251	homer scaffolding protein 1	Mus musculus	66-73
22808907-3	2012	In addition, we recently reported that the global deletion of the Homer 1 proteins in mice leads to a conspicuous endocrine phenotype linked to hypertrophy of the adrenal cortex, elevated basal and/or adrenocorticotropic hormone-induced corticosterone and aldosterone release in vitro and in vivo, as well as a drastic increase in the adrenocorticotropic hormone receptor mRNA in the adrenocortical cells.	Corticosterone	237-251	pro-opiomelanocortin-alpha	Mus musculus	201-228
22426399-0	2012	Long-term behavioral and NMDA receptor effects of young-adult corticosterone treatment in BDNF heterozygous mice.	Corticosterone	62-76	brain derived neurotrophic factor	Mus musculus	90-94
22426399-3	2012	The aim of the present study was to assess the combined effect of reduced BDNF levels and postnatal stress, simulated by chronic young-adult treatment with the stress hormone, corticosterone.	Corticosterone	176-190	brain derived neurotrophic factor	Mus musculus	74-78
22426399-8	2012	Analysis of protein levels of the NMDA receptor subunits NR1, NR2A, NR2B and NR2C, showed a marked increase of NR2B levels in the dorsal hippocampus of male BDNF heterozygous mice treated with corticosterone.	Corticosterone	193-207	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	57-60
22426399-8	2012	Analysis of protein levels of the NMDA receptor subunits NR1, NR2A, NR2B and NR2C, showed a marked increase of NR2B levels in the dorsal hippocampus of male BDNF heterozygous mice treated with corticosterone.	Corticosterone	193-207	glutamate receptor, ionotropic, NMDA2C (epsilon 3)	Mus musculus	77-81
22426399-8	2012	Analysis of protein levels of the NMDA receptor subunits NR1, NR2A, NR2B and NR2C, showed a marked increase of NR2B levels in the dorsal hippocampus of male BDNF heterozygous mice treated with corticosterone.	Corticosterone	193-207	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	111-115
22426399-8	2012	Analysis of protein levels of the NMDA receptor subunits NR1, NR2A, NR2B and NR2C, showed a marked increase of NR2B levels in the dorsal hippocampus of male BDNF heterozygous mice treated with corticosterone.	Corticosterone	193-207	brain derived neurotrophic factor	Mus musculus	157-161
22360938-5	2012	SULT3 ST5 showed weaker, but significant, activities toward endogenous compounds such as DHEA and corticosterone, as well as xenobiotics including mestranol, beta-naphthylamine, beta-naphthol, and butylated hydroxyl anisole (BHA).	Corticosterone	98-112	sulfotransferase family 3, cytosolic sulfotransferase 3	Danio rerio	0-9
22398685-5	2012	Calm, Cntl Ex and Calm Ex animals exhibited significantly less corticosterone production than Cntl animals.	Corticosterone	63-77	phosphatidylinositol binding clathrin assembly protein	Mus musculus	18-22
22205277-7	2012	In addition, piperine (1 muM) co-treatment was found to reverse the decreased brain-derived neurotrophic factor (BDNF) mRNA level caused by corticosterone in PC12 cells.	Corticosterone	140-154	brain-derived neurotrophic factor	Rattus norvegicus	78-111
22205277-7	2012	In addition, piperine (1 muM) co-treatment was found to reverse the decreased brain-derived neurotrophic factor (BDNF) mRNA level caused by corticosterone in PC12 cells.	Corticosterone	140-154	brain-derived neurotrophic factor	Rattus norvegicus	113-117
22205277-8	2012	The results suggest that piperine exerts a neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells, at least in part, via the inhibition of oxidative stress and the upregulation of BDNF mRNA expression.	Corticosterone	69-83	brain-derived neurotrophic factor	Rattus norvegicus	202-206
22561136-8	2012	However, TNFR1+2-/- mice had significantly higher corticosterone concentrations than C57BL/6J mice after SDR.	Corticosterone	50-64	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	9-14
22535769-5	2012	Cosyntropin-stimulated corticosterone production is decreased 35 and 50% in male and female Vimentin null (Vim(-/-)) mice, respectively, whereas progesterone production is decreased 70% in female Vim(-/-) mice after pregnant mare"s serum gonadotropin and human chorionic gonadotropin stimulation, but no abnormalities in human chorionic gonadotropin-stimulated testosterone production is observed in male Vim(-/-) mice.	Corticosterone	23-37	vimentin	Mus musculus	92-100
22535769-5	2012	Cosyntropin-stimulated corticosterone production is decreased 35 and 50% in male and female Vimentin null (Vim(-/-)) mice, respectively, whereas progesterone production is decreased 70% in female Vim(-/-) mice after pregnant mare"s serum gonadotropin and human chorionic gonadotropin stimulation, but no abnormalities in human chorionic gonadotropin-stimulated testosterone production is observed in male Vim(-/-) mice.	Corticosterone	23-37	vimentin	Mus musculus	92-95
22822522-2	2012	Male SD rats were subjected to restraint or cold stress for 2 h, and then mRNA expression of corticotropin-releasing hormone (CRH) in the hypothalamic paraventricular nucleus (PVN) was examined by in situ hybridization and the plasma corticosterone levels by radioimmunoassay.	Corticosterone	234-248	corticotropin releasing hormone	Rattus norvegicus	126-129
22543192-10	2012	Furthermore, MR(CaMKCre) mice showed increased GR mRNA expression in all CA areas of the hippocampus and an altered basal and stress-induced corticosterone secretion, which supports their role in the modulation of neuroendocrine activity.	Corticosterone	141-155	nuclear receptor subfamily 3, group C, member 2	Mus musculus	13-15
22779090-5	2012	Dexamethasone, a synthetic glucocorticoid, was administered to agonize the effects of corticosterone.Our results show that both G-CSF and metyrapone significantly reduced infarct volume while dexamethasone treatment did not reduce infarct size even when combined with G-CSF.	Corticosterone	86-100	colony stimulating factor 3	Rattus norvegicus	128-133
22779090-7	2012	G-CSF did not affect the pituitary released adrenocorticotropic hormone (ACTH) levels in the blood plasma at 4 h, but suppressed the increase of corticosterone in the blood.	Corticosterone	145-159	colony stimulating factor 3	Rattus norvegicus	0-5
22779090-9	2012	The combination of G-CSF and metyrapone significantly decreased caspase-3 protein levels in the brain, and the effect was antagonized by dexamethasone.We report that G-CSF is neuroprotective in neonatal HI by reducing infarct volume, by suppressing the HI-induced increase of the Bax/Bcl-2 ratio, and by decreasing corticosterone in the blood.	Corticosterone	315-329	colony stimulating factor 3	Rattus norvegicus	19-24
22779090-9	2012	The combination of G-CSF and metyrapone significantly decreased caspase-3 protein levels in the brain, and the effect was antagonized by dexamethasone.We report that G-CSF is neuroprotective in neonatal HI by reducing infarct volume, by suppressing the HI-induced increase of the Bax/Bcl-2 ratio, and by decreasing corticosterone in the blood.	Corticosterone	315-329	colony stimulating factor 3	Rattus norvegicus	166-171
22131171-5	2012	Paeoniflorin also reversed the reduced nerve growth factor (NGF) mRNA level caused by corticosterone in PC12 cells.	Corticosterone	86-100	nerve growth factor	Rattus norvegicus	39-58
22131171-5	2012	Paeoniflorin also reversed the reduced nerve growth factor (NGF) mRNA level caused by corticosterone in PC12 cells.	Corticosterone	86-100	nerve growth factor	Rattus norvegicus	60-63
22131171-6	2012	The results suggest that paeoniflorin exerts a neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells, at least in part, via the inhibition of oxidative stress and the up-regulation of NGF expression.	Corticosterone	73-87	nerve growth factor	Rattus norvegicus	207-210
22244747-0	2012	Corticosterone reduces brain mitochondrial function and expression of mitofusin, BDNF in depression-like rodents regardless of exercise preconditioning.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	81-85
22244747-2	2012	To further link mitochondrial dysfunction to the pathophysiology of major depression, here we describe two rat models of a depressive-like state induced by chronic unpredictable mild stress (CUMS) or corticosterone treatment (CORT).	Corticosterone	200-214	cortistatin	Rattus norvegicus	226-230
22074385-8	2012	Two hours after corticosterone administration, plasma glucocorticoid concentrations were comparable to those observed after restraint stress, while N/OFQ expression had significantly increased in all the hippocampal subfields examined.	Corticosterone	16-30	prepronociceptin	Homo sapiens	148-153
22681886-2	2012	We now show that PrxIII in mouse adrenal cortex is inactivated by H(2)O(2) produced by cytochrome P450 enzymes during corticosterone production stimulated by adrenocorticotropic hormone.	Corticosterone	118-132	peroxiredoxin 3	Mus musculus	17-23
22573815-4	2012	Close examination of the hypothalamic-pituitary-adrenal axis showed that MC3-R(-/-) mice exhibit elevated nadir corticosterone as well as a blunted fasting-induced activation of the axis.	Corticosterone	112-126	melanocortin 3 receptor	Mus musculus	73-78
22492693-1	2012	Activation of the central amygdala (CeA) by corticosterone (CORT) induces somatic and colonic hypersensitivity through corticotrophin-releasing factor (CRF)-dependent mechanisms.	Corticosterone	44-58	cortistatin	Homo sapiens	60-64
22492693-1	2012	Activation of the central amygdala (CeA) by corticosterone (CORT) induces somatic and colonic hypersensitivity through corticotrophin-releasing factor (CRF)-dependent mechanisms.	Corticosterone	44-58	corticotropin releasing hormone	Homo sapiens	119-150
22672302-7	2012	We also found that NPY decreased BDNF levels in the hypothalamus and corticosterone levels in plasma.	Corticosterone	69-83	neuropeptide Y	Rattus norvegicus	19-22
22356098-3	2012	In the present study, plasma concentrations of oxytocin, vasopressin and corticosterone (CORT) were measured in reproductively naive male prairie voles as a function of exposure to an infant or control manipulations (i.e. handling or exposure to a wooden dowel).	Corticosterone	73-87	cortistatin	Microtus ochrogaster	89-93
22560194-7	2012	To pursue the involvement of corticosterone-mediated Zn(2+) signal in the attenuated CA1 LTP by stress, dynamics of synaptic Zn(2+) was checked in hippocampal slices exposed to corticosterone.	Corticosterone	29-43	carbonic anhydrase 1	Rattus norvegicus	85-88
22560194-10	2012	Furthermore, corticosterone-induced attenuation of CA1 LTP was abolished in the coexistence of CaEDTA.	Corticosterone	13-27	carbonic anhydrase 1	Rattus norvegicus	51-54
22560194-11	2012	The present study suggests that corticosterone-mediated increase in postsynaptic Zn(2+) signal in the cytosolic compartment is involved in the attenuation of CA1 LTP after exposure to acute stress.	Corticosterone	32-46	carbonic anhydrase 1	Rattus norvegicus	158-161
22610366-0	2012	Corticosterone regulates the expression of neuropeptide Y and reelin in MLO-Y4 cells.	Corticosterone	0-14	neuropeptide Y	Mus musculus	43-57
22610366-0	2012	Corticosterone regulates the expression of neuropeptide Y and reelin in MLO-Y4 cells.	Corticosterone	0-14	reelin	Mus musculus	62-68
22610366-4	2012	In this study, we investigated the in vitro effect of corticosterone, one of the endogenous glucocorticoids, on the expression of NPY and reelin in the MLO-Y4 osteocyte cell line.	Corticosterone	54-68	neuropeptide Y	Mus musculus	130-133
22610366-4	2012	In this study, we investigated the in vitro effect of corticosterone, one of the endogenous glucocorticoids, on the expression of NPY and reelin in the MLO-Y4 osteocyte cell line.	Corticosterone	54-68	reelin	Mus musculus	138-144
22610366-7	2012	These results demonstrated that at the gene and the protein levels, corticosterone significantly upregulated the NPY and reelin expression in a time-dependent manner.	Corticosterone	68-82	neuropeptide Y	Mus musculus	113-116
22610366-7	2012	These results demonstrated that at the gene and the protein levels, corticosterone significantly upregulated the NPY and reelin expression in a time-dependent manner.	Corticosterone	68-82	reelin	Mus musculus	121-127
22610366-8	2012	The application of a glucocorticoid receptor antagonist, RU486, reversed the reduced cell viability and the increased expression of NPY and reelin that were caused by corticosterone.	Corticosterone	167-181	neuropeptide Y	Mus musculus	132-135
22610366-8	2012	The application of a glucocorticoid receptor antagonist, RU486, reversed the reduced cell viability and the increased expression of NPY and reelin that were caused by corticosterone.	Corticosterone	167-181	reelin	Mus musculus	140-146
22610366-9	2012	To the best of our knowledge, this is the first report to verify that corticosterone regulates the NPY and reelin expression in osteocytes.	Corticosterone	70-84	neuropeptide Y	Mus musculus	99-102
22610366-9	2012	To the best of our knowledge, this is the first report to verify that corticosterone regulates the NPY and reelin expression in osteocytes.	Corticosterone	70-84	reelin	Mus musculus	107-113
22539732-1	2012	Chronic increases in circulating corticosterone (CORT) generally suppress immune function, but it is not known whether evolved increases necessarily have similar adverse effects.	Corticosterone	33-47	cortistatin	Mus musculus	49-53
22339976-12	2012	Injection of exogenous corticosterone resulted in significant reductions of immobility in the FST in abcb1a/1b (-/-) mice, whereas wild-type mice did not respond to the same doses.	Corticosterone	23-37	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	101-107
22333290-7	2012	Corticosterone (CORT) levels were drastically reduced only in CRF KO mice.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
22334122-8	2012	S1 with a history of chronic restraint stress displayed an attenuated corticosterone (CORT) response to a novel, swim stressor.	Corticosterone	70-84	cortistatin	Mus musculus	86-90
22450046-7	2012	Importantly, the stress-induced increase in corticosterone was more pronounced in Nrg1 mutant than WT mice at the younger but not the older age.	Corticosterone	44-58	neuregulin 1	Mus musculus	82-86
21924839-0	2012	Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression.	Corticosterone	21-35	tryptophan hydroxylase 2	Rattus norvegicus	84-88
21924839-10	2012	Remarkably, all doses of corticosterone treatment abolished the diurnal variation of tph2 mRNA expression in the brainstem dorsal raphe nucleus (DR) by elevating the gene"s expression during the animals" inactive (light) phase.	Corticosterone	25-39	tryptophan hydroxylase 2	Rattus norvegicus	85-89
21924839-11	2012	Our data demonstrate that chronic elevation of corticosterone creates a vulnerability to a depression-like syndrome that is associated with increased tph2 expression, similar to that observed in depressed patients.	Corticosterone	47-61	tryptophan hydroxylase 2	Homo sapiens	150-154
21995501-0	2012	Environmental enrichment in male CD-1 mice promotes aggressive behaviors and elevated corticosterone and brain norepinephrine activity in response to a mild stressor.	Corticosterone	86-100	CD1 antigen complex	Mus musculus	33-37
22812002-3	2012	In parallel, corticosterone caused significant elevations of DNA fragmentation, [Ca2+]i and caspase-3 activity.	Corticosterone	13-27	caspase 3	Rattus norvegicus	92-101
22146309-4	2012	Corticosterone increased GTP-bound G(s) protein and cyclic AMP (cAMP) production, activated phospholipase Cbeta(3) (PLC-beta(3)), and induced inositol-1,4,5-triphosphate (IP(3)) production.	Corticosterone	0-14	cathelicidin antimicrobial peptide	Homo sapiens	52-69
22146309-4	2012	Corticosterone increased GTP-bound G(s) protein and cyclic AMP (cAMP) production, activated phospholipase Cbeta(3) (PLC-beta(3)), and induced inositol-1,4,5-triphosphate (IP(3)) production.	Corticosterone	0-14	phospholipase C beta 3	Homo sapiens	92-114
22146309-4	2012	Corticosterone increased GTP-bound G(s) protein and cyclic AMP (cAMP) production, activated phospholipase Cbeta(3) (PLC-beta(3)), and induced inositol-1,4,5-triphosphate (IP(3)) production.	Corticosterone	0-14	phospholipase C beta 3	Homo sapiens	116-127
22146309-5	2012	Blocking PLC and the downstream cascades with PLC inhibitor, IP(3) receptor antagonist, Ca(2+) chelator, and protein kinase C (PKC) inhibitors prevented the actions of corticosterone.	Corticosterone	168-182	heparan sulfate proteoglycan 2	Homo sapiens	9-12
22146309-5	2012	Blocking PLC and the downstream cascades with PLC inhibitor, IP(3) receptor antagonist, Ca(2+) chelator, and protein kinase C (PKC) inhibitors prevented the actions of corticosterone.	Corticosterone	168-182	heparan sulfate proteoglycan 2	Homo sapiens	46-49
22146309-5	2012	Blocking PLC and the downstream cascades with PLC inhibitor, IP(3) receptor antagonist, Ca(2+) chelator, and protein kinase C (PKC) inhibitors prevented the actions of corticosterone.	Corticosterone	168-182	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	61-75
22546913-6	2012	In addition, we found higher levels of excreted corticosterone in Tg-RCAN1(TG) female mice as compared  with female wildtype mice.	Corticosterone	48-62	regulator of calcineurin 1	Mus musculus	66-78
22546913-0	2012	Fecal corticosterone levels in RCAN1 mutant mice.	Corticosterone	6-20	regulator of calcineurin 1	Mus musculus	31-36
22309318-2	2012	Oxytocin and corticosterone (CORT) interact to mediate hormonal stress responses and can be altered by cocaine use.	Corticosterone	13-27	cortistatin	Rattus norvegicus	29-33
21965192-4	2012	Since both noradrenaline and corticosterone are known to quickly affect properties of AMPA-type glutamate receptors (AMPAR), we here examined - in hippocampal neurons - three parameters which give insight in the functionality of AMPARs: phosphorylation, surface expression and spontaneous synaptic transmission.	Corticosterone	29-43	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	229-235
22243963-3	2012	Among those, one showed significant neuroprotective activities against both glutamate-induced and corticosterone-induced neurotoxicity in P12 pheochromocytoma and human U251 glioma cells at a concentration of 10 muM and increased cell viability by 82.2% and 86.9%, respectively.	Corticosterone	98-112	latexin	Homo sapiens	212-215
22331421-4	2012	We found that HDAC6 inhibition or knockdown blocked the enhancement of glutamatergic transmission and glutamate receptor trafficking by acute stress in vivo or corticosterone treatment in vitro.	Corticosterone	160-174	histone deacetylase 6	Homo sapiens	14-19
22016195-2	2012	Given that interoceptive/subjective drug cues are a fundamental factor in drug-taking behavior, we sought to determine the effects of exposure to repeated elevations in the glucocorticoid corticosterone (CORT) on the interoceptive effects of alcohol in rats using drug discrimination techniques.	Corticosterone	188-202	cortistatin	Rattus norvegicus	204-208
22280973-5	2012	Plasma corticosterone (CORT) levels increased similarly in MOR-1 KO and WT mice following both single and repeated injection, indicating that the stress response is activated following any injection protocol, but that the mechanism responsible for the increase in BrdU labeling in MOR-1 KO mice is CORT-level independent.	Corticosterone	7-21	cortistatin	Mus musculus	23-27
22399716-8	2012	Levels of corticosterone and the heterophil:lymphocyte ratio significantly increased when HSP70 expression was inhibited (P &lt; 0.0001).	Corticosterone	10-24	heat shock protein family A (Hsp70) member 4	Homo sapiens	90-95
22399716-9	2012	Serum corticosterone was negatively correlated with the HSP70 expression at 3 h of heat stress (P = 0.0015; R = -0.6537).	Corticosterone	6-20	heat shock protein family A (Hsp70) member 4	Homo sapiens	56-61
22457490-5	2012	Pet1-Cre-driven deletion of HDAC6 in serotonin neurons, the densest HDAC6-expressing cell group in the mouse brain, dramatically reduced acute anxiogenic effects of the glucocorticoid hormone corticosterone in the open-field, elevated plus maze, and social interaction tests.	Corticosterone	192-206	plasmacytoma expressed transcript 1	Mus musculus	0-4
22260943-5	2012	Administration of ACTH resulted in a dose-dependent increase in corticosterone and progesterone release in mice-exposed to low-concentration NR-DE and clean air.	Corticosterone	64-78	pro-opiomelanocortin-alpha	Mus musculus	18-22
22260943-6	2012	Moreover, corticosterone and progesterone concentrations in adrenal cells increased significantly in mice-exposed to low-concentration NR-DE basal and administrated with ACTH (10(-15) to 10(-11)M for corticosterone; 10(-14) to 10(-11)M for progesterone) compared with the control mice.	Corticosterone	10-24	pro-opiomelanocortin-alpha	Mus musculus	170-174
22260943-6	2012	Moreover, corticosterone and progesterone concentrations in adrenal cells increased significantly in mice-exposed to low-concentration NR-DE basal and administrated with ACTH (10(-15) to 10(-11)M for corticosterone; 10(-14) to 10(-11)M for progesterone) compared with the control mice.	Corticosterone	200-214	pro-opiomelanocortin-alpha	Mus musculus	170-174
22260943-7	2012	In contrast, the concentration of corticosterone and progesterone decreased significantly in mice-exposed to high-concentration NR-DE or F-DE basal and administrated with ACTH (10(-12) to 10(-10)M for corticosterone; 10(-15) to 10(-10)M for progesterone) compared with the control mice.	Corticosterone	34-48	pro-opiomelanocortin-alpha	Mus musculus	171-175
22260943-7	2012	In contrast, the concentration of corticosterone and progesterone decreased significantly in mice-exposed to high-concentration NR-DE or F-DE basal and administrated with ACTH (10(-12) to 10(-10)M for corticosterone; 10(-15) to 10(-10)M for progesterone) compared with the control mice.	Corticosterone	201-215	pro-opiomelanocortin-alpha	Mus musculus	171-175
22192380-7	2012	COMT KO mice demonstrated an increased corticosterone response to acute but not chronic stress, and a modified cytokine profile after chronic, but not acute stress.	Corticosterone	39-53	catechol-O-methyltransferase	Mus musculus	0-4
22457490-5	2012	Pet1-Cre-driven deletion of HDAC6 in serotonin neurons, the densest HDAC6-expressing cell group in the mouse brain, dramatically reduced acute anxiogenic effects of the glucocorticoid hormone corticosterone in the open-field, elevated plus maze, and social interaction tests.	Corticosterone	192-206	histone deacetylase 6	Mus musculus	28-33
22457490-5	2012	Pet1-Cre-driven deletion of HDAC6 in serotonin neurons, the densest HDAC6-expressing cell group in the mouse brain, dramatically reduced acute anxiogenic effects of the glucocorticoid hormone corticosterone in the open-field, elevated plus maze, and social interaction tests.	Corticosterone	192-206	histone deacetylase 6	Mus musculus	68-73
22153720-5	2012	When the levels of corticosterone - the prevalent corticosteroid in rats and mice- are low, L-type Ca(2+) currents of CA1 hippocampal cells are small.	Corticosterone	19-33	carbonic anhydrase 1	Mus musculus	118-121
22253426-8	2012	Glucocorticoids, including dexamethasone, cortisol, corticosterone, and cortisone all induced the expression of CYP3A7 mRNA, whereas rifampicin, an activator of PXR and an inducer of CYP3A4 in adult liver, had no effect on CYP3A7 expression.	Corticosterone	52-66	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	112-118
22253426-8	2012	Glucocorticoids, including dexamethasone, cortisol, corticosterone, and cortisone all induced the expression of CYP3A7 mRNA, whereas rifampicin, an activator of PXR and an inducer of CYP3A4 in adult liver, had no effect on CYP3A7 expression.	Corticosterone	52-66	nuclear receptor subfamily 1, group I, member 2	Mus musculus	161-164
22253426-8	2012	Glucocorticoids, including dexamethasone, cortisol, corticosterone, and cortisone all induced the expression of CYP3A7 mRNA, whereas rifampicin, an activator of PXR and an inducer of CYP3A4 in adult liver, had no effect on CYP3A7 expression.	Corticosterone	52-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	183-189
22253426-8	2012	Glucocorticoids, including dexamethasone, cortisol, corticosterone, and cortisone all induced the expression of CYP3A7 mRNA, whereas rifampicin, an activator of PXR and an inducer of CYP3A4 in adult liver, had no effect on CYP3A7 expression.	Corticosterone	52-66	cytochrome P450 family 3 subfamily A member 7	Homo sapiens	223-229
21136520-0	2012	Early life stress stimulates hippocampal reelin gene expression in a sex-specific manner: evidence for corticosterone-mediated action.	Corticosterone	103-117	reelin	Mus musculus	41-47
21136520-9	2012	To address the question whether corticosterone mediates the stress-induced up-regulation of reelin gene expression, we used age-matched hippocampal slice cultures derived from male and female mouse pups.	Corticosterone	32-46	reelin	Mus musculus	92-98
21136520-10	2012	Quantitative determination of mRNA levels revealed that corticosterone treatment significantly up-regulated reelin mRNA expression in male, but not in female hippocampi.	Corticosterone	56-70	reelin	Mus musculus	108-114
21136520-11	2012	Taken together, these results show a sex-specific regulation of reelin gene expression by early life experience, most likely mediated by corticosterone.	Corticosterone	137-151	reelin	Mus musculus	64-70
22191943-0	2012	Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors.	Corticosterone	33-47	corticotropin releasing hormone	Mus musculus	57-60
22191943-0	2012	Nicotine stimulates secretion of corticosterone via both CRH and AVP receptors.	Corticosterone	33-47	arginine vasopressin	Mus musculus	65-68
22191943-8	2012	We found that CRH enhanced corticosterone release, and this response was blocked by both AST and ANT.	Corticosterone	27-41	corticotropin releasing hormone	Mus musculus	14-17
22191943-12	2012	Although the AVP antagonist did not alter basal or nicotine-stimulated corticosterone secretion, it attenuated the AVP-induced stimulation of corticosterone and its combination with AST but not AST2b completely abolished nicotine-mediated stimulation of corticosterone secretion.	Corticosterone	142-156	arginine vasopressin	Mus musculus	115-118
22191943-12	2012	Although the AVP antagonist did not alter basal or nicotine-stimulated corticosterone secretion, it attenuated the AVP-induced stimulation of corticosterone and its combination with AST but not AST2b completely abolished nicotine-mediated stimulation of corticosterone secretion.	Corticosterone	142-156	arginine vasopressin	Mus musculus	115-118
22191943-13	2012	Our results demonstrate that the nicotine-induced stimulation of the hypothalamic-pituitary-adrenal axis is mediated by both the CRH-R and the AVP V(1b) receptor and when the CRH receptor is blocked, nicotine may utilize the AVP V(1b) receptor to mediate secretion of corticosterone.	Corticosterone	268-282	corticotropin releasing hormone	Mus musculus	175-178
22191943-14	2012	These results argue in favor of the development of specific antagonists that block both AVP and CRH receptors to decrease the pleasurable component of nicotine, which may be mediated by corticosterone.	Corticosterone	186-200	arginine vasopressin	Mus musculus	88-91
22191943-14	2012	These results argue in favor of the development of specific antagonists that block both AVP and CRH receptors to decrease the pleasurable component of nicotine, which may be mediated by corticosterone.	Corticosterone	186-200	corticotropin releasing hormone	Mus musculus	96-99
21687973-4	2012	PACAP treatment increased ACTH, corticosterone, LH and FSH blood concentrations, while it decreased TSH levels.	Corticosterone	32-46	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-5
22306774-6	2012	To pursue the involvement of corticosterone-mediated Zn(2+) signal in the attenuated CA1 LTP by stress, dynamics of synaptic Zn(2+) was checked in hippocampal slices exposed to corticosterone.	Corticosterone	29-43	carbonic anhydrase 1	Rattus norvegicus	85-88
22306774-9	2012	Furthermore, corticosterone-induced attenuation of CA1 LTP was abolished in the coexistence of CaEDTA.	Corticosterone	13-27	carbonic anhydrase 1	Rattus norvegicus	51-54
22306774-10	2012	The present study suggests that corticosterone-mediated increase in postsynaptic Zn(2+) signal in the cytosolic compartment is involved in the attenuation of CA1 LTP after exposure to acute stress.	Corticosterone	32-46	carbonic anhydrase 1	Rattus norvegicus	158-161
22331883-5	2012	Importantly, a blockade of hippocampal CB1 receptors with AM251 prevented the impairing effect of corticosterone on retrieval of contextual fear memory, whereas the same impairing dose of corticosterone increased hippocampal levels of the endocannabinoid 2-arachidonoylglycerol.	Corticosterone	98-112	cannabinoid receptor 1	Rattus norvegicus	39-42
22331883-5	2012	Importantly, a blockade of hippocampal CB1 receptors with AM251 prevented the impairing effect of corticosterone on retrieval of contextual fear memory, whereas the same impairing dose of corticosterone increased hippocampal levels of the endocannabinoid 2-arachidonoylglycerol.	Corticosterone	188-202	cannabinoid receptor 1	Rattus norvegicus	39-42
22114025-6	2012	An NADPH oxidase inhibitor, apocynin, blocked the nongenomic actions of MRs. A Rac1 inhibitor, NSC23766, was also found to block synaptic enhancement and ERK1/2 phosphorylation induced by NADPH and corticosterone.	Corticosterone	198-212	Rac family small GTPase 1	Rattus norvegicus	79-83
22408607-3	2012	Regulation of NMDAR function by cortisol/corticosterone (CORT) may be fundamental to the effects of stress on synaptic plasticity.	Corticosterone	41-55	cortistatin	Homo sapiens	57-61
21893170-4	2012	Four hours after the LPS injection, levels of corticosterone (COR) and pro-inflammatory cytokines (PIC) in pregnant mice, as compared to the control dams, were increased significantly.	Corticosterone	46-60	distribution of corticosterone in adrenal cortex cells	Mus musculus	62-65
22308466-3	2012	Here we tested this hypothesis using physical development, indexed by body weight, as an endpoint and found that, among offspring of mothers with a high initial swim-stress-induced corticosterone (CORT) response, neonatal novelty exposure induced an enhancement in early growth, and among offspring with mothers of a low initial CORT response, the same neonatal stimulation induced an impairment.	Corticosterone	181-195	cortistatin	Homo sapiens	197-201
21917408-2	2012	Given that corticosterone (CORT) has been shown to be related to the intake of several drugs of abuse, this study assessed the ontogenetic effects of low-moderate doses of ethanol on CORT increases and recovery.	Corticosterone	11-25	cortistatin	Rattus norvegicus	27-31
22111694-5	2012	RESULTS: Mouse lung tissue was found to express steroidogenic enzymes required for the synthesis of corticosterone from cholesterol and to synthesize corticosterone in large quantities after immune cell activation by anti-CD3 antibody, lipopolysaccharide, or TNFalpha.	Corticosterone	150-164	CD3 antigen, epsilon polypeptide	Mus musculus	222-225
22111694-5	2012	RESULTS: Mouse lung tissue was found to express steroidogenic enzymes required for the synthesis of corticosterone from cholesterol and to synthesize corticosterone in large quantities after immune cell activation by anti-CD3 antibody, lipopolysaccharide, or TNFalpha.	Corticosterone	150-164	tumor necrosis factor	Mus musculus	259-267
22111694-7	2012	Although the lung expresses all steroidogenic enzymes necessary for de novo synthesis of corticosterone from cholesterol, functional data indicated that inactive serum-derived dehydrocorticosterone is converted to active corticosterone by 11beta-hydroxysteroid dehydrogenase 1.	Corticosterone	183-197	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	239-276
22127931-7	2012	Mice are sensitive to glucocorticoid-induced cleft palates, and NK-1 antagonists are known to modulate the hypothalamic-pituitary-adrenal axis leading to increases in corticosterone.	Corticosterone	167-181	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	64-68
22119711-0	2012	Peony glycosides reverse the effects of corticosterone on behavior and brain BDNF expression in rats.	Corticosterone	40-54	brain-derived neurotrophic factor	Rattus norvegicus	77-81
22119711-1	2012	Repeated injections of corticosterone (CORT) induce the dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in depressive-like behavior.	Corticosterone	23-37	cortistatin	Rattus norvegicus	39-43
22128027-2	2012	Here, we show that acute stress increases 7alpha-OH PREG synthesis in the dorsomedial hypothalamus (DMH) through corticosterone (CORT) action in newts.	Corticosterone	113-127	cortistatin	Homo sapiens	129-133
22232135-8	2012	BSO significantly enhanced the corticosterone-induced, mineralocorticoid receptor-dependent luciferase reporter activity (186%; P&lt;0.01) and basal luciferase activity without ligand stimulation.	Corticosterone	31-45	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	55-81
20416975-1	2012	The main purpose of this study was to evaluate the effect of aging on plasma and free corticosterone (CORT) levels in the brain in basal conditions and in response to an acute stressor.	Corticosterone	86-100	cortistatin	Rattus norvegicus	102-106
22134693-10	2012	Serum BDNF levels did not change either, but serum BDNF was negatively correlated to peripheral corticosterone concentrations, indicating a possible inhibitory reaction to the stress of running.	Corticosterone	96-110	brain-derived neurotrophic factor	Rattus norvegicus	51-55
21779782-7	2012	This 60-mug/ml concentration also restored hippocampal brain-derived neuroptrophic factor (BDNF) expression after chronic corticosteroid exposure and increased glutamate glial transporter 1 (GLT-1, or EAAT2) expression without significantly affecting baseline locomotor activity, thymus and adrenal gland weights, or blood serum corticosterone.	Corticosterone	329-343	brain derived neurotrophic factor	Mus musculus	91-95
22178014-3	2012	Glucocorticoids have been reported to promote fetal and neonatal lung development at the late stage, and 11beta-hydroxysteroid dehydrogenase 1(11betaHSD1) in the lung is critical for the generation of local active glucocorticoid cortisol (human) or corticosterone (rodents) from biologically inert 11keto-steroids.	Corticosterone	249-263	RNA, U1 small nuclear 1	Homo sapiens	105-153
22043004-5	2012	[d-Ala(2)]GIP increased murine corticosterone levels in a GIPR-dependent manner.	Corticosterone	31-45	gastric inhibitory polypeptide	Mus musculus	10-13
22582138-9	2012	We also found increases in hippocampal NGF and plasma corticosterone following MDMA treatment on P16 and P21, respectively.	Corticosterone	54-68	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	97-100
22582138-9	2012	We also found increases in hippocampal NGF and plasma corticosterone following MDMA treatment on P16 and P21, respectively.	Corticosterone	54-68	KRAS proto-oncogene, GTPase	Rattus norvegicus	105-108
22052012-2	2012	Previously, we demonstrated that the stress hormone corticosterone applied directly to the amygdala induced visceral hypersensitivity through the actions of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR).	Corticosterone	52-66	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	157-180
22052012-2	2012	Previously, we demonstrated that the stress hormone corticosterone applied directly to the amygdala induced visceral hypersensitivity through the actions of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR).	Corticosterone	52-66	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	182-184
22052012-2	2012	Previously, we demonstrated that the stress hormone corticosterone applied directly to the amygdala induced visceral hypersensitivity through the actions of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR).	Corticosterone	52-66	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	190-216
22052012-2	2012	Previously, we demonstrated that the stress hormone corticosterone applied directly to the amygdala induced visceral hypersensitivity through the actions of glucocorticoid receptor (GR) and mineralocorticoid receptor (MR).	Corticosterone	52-66	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	218-220
21907245-3	2012	Animals that swam under BLC had a higher serum corticosterone level than those under DLC.	Corticosterone	47-61	chemokine (C-X-C motif) ligand 13	Mus musculus	24-27
21907737-1	2012	Previous evidence indicates that peripherally administered ghrelin significantly increases corticotropin releasing hormone (CRH) mRNA and serum corticosterone.	Corticosterone	144-158	ghrelin and obestatin prepropeptide	Rattus norvegicus	59-66
22863925-2	2012	The main regulator of intracellular glucocorticoid levels are 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which converts inactive glucocorticoid into bioactive glucocorticoid such as cortisol in humans and corticosterone in rodents; therefore, the inhibition of 11beta-HSD1 has considerable therapeutic potential for metabolic diseases including obesity and diabetes.	Corticosterone	220-234	RNA, U1 small nuclear 1	Homo sapiens	62-117
22863925-2	2012	The main regulator of intracellular glucocorticoid levels are 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which converts inactive glucocorticoid into bioactive glucocorticoid such as cortisol in humans and corticosterone in rodents; therefore, the inhibition of 11beta-HSD1 has considerable therapeutic potential for metabolic diseases including obesity and diabetes.	Corticosterone	220-234	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	106-117
23127884-6	2012	In the present study, we investigated the effects of LBP on counteracting depression using an animal model injected with moderate dose (40 mg/kg) or severe dose (50 mg/kg) of corticosterone (CORT) treatments  for 14 days.	Corticosterone	175-189	cortistatin	Rattus norvegicus	191-195
23186919-6	2012	RESULTS: The levels of corticosterone were significantly higher in stress groups than that in corresponding control groups (P less than 0.05), especially in CRH+/+ stress group (P less than 0.01).	Corticosterone	23-37	corticotropin releasing hormone	Mus musculus	157-160
22043004-5	2012	[d-Ala(2)]GIP increased murine corticosterone levels in a GIPR-dependent manner.	Corticosterone	31-45	gastric inhibitory polypeptide receptor	Mus musculus	58-62
22043004-6	2012	Conversely, basal corticosterone levels were reduced, whereas food deprivation resulted in significantly enhanced plasma corticosterone levels in Gipr(-/-) mice.	Corticosterone	121-135	gastric inhibitory polypeptide receptor	Mus musculus	146-150
20674316-3	2012	The hyperglycemic outcome at 2 h was accompanied by significant inhibition of acetylcholinesterase (AChE) activity in brain (84%), adrenal (68%) and liver (53%) and stressogenic effects as revealed by marked increase in plasma corticosterone (102%) and liver tyrosine aminotransferase (TAT) (104%) activity.	Corticosterone	227-241	acetylcholinesterase	Rattus norvegicus	100-104
21585422-4	2012	The MR has similar affinity for aldosterone and the glucocorticoids corticosterone or cortisol.	Corticosterone	68-82	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	4-6
22087024-7	2012	A corticosterone response to injection of CRH (1 mug, iv) during the period of maximal suppression indicated a suprapituitary site for the inhibitory effect glucocorticoid activation.	Corticosterone	2-16	corticotropin releasing hormone	Rattus norvegicus	42-45
22106159-0	2012	Somatostatin receptor type 2 antagonism improves glucagon and corticosterone counterregulatory responses to hypoglycemia in streptozotocin-induced diabetic rats.	Corticosterone	62-76	somatostatin receptor 2	Rattus norvegicus	0-28
22106159-12	2012	We demonstrate that SSTR2 antagonism enhances hypoglycemia-stimulated glucagon and corticosterone release in D but not in N rats.	Corticosterone	83-97	somatostatin receptor 2	Rattus norvegicus	20-25
22792090-7	2012	As for 11beta-HSD1 is a regulating enzyme, converting the inactive 11-dehydrocorticosterone into the active glucocorticoid corticosterone, thus amplifying GC action in local tissues.	Corticosterone	77-91	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	7-18
22067318-3	2012	In vivo, 11beta-HSD1 catalyzes the reduction of inactive cortisone or 11-dehydrocorticosterone into active cortisol or corticosterone, respectively, thereby increasing intracellular glucocorticoid levels.	Corticosterone	80-94	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	9-20
22201948-4	2012	In the present study, we induced osteoporosis in rats by corticosterone (CORT) and ovariectomy (OVX), treated both with ICA for 2 weeks or 3 months.	Corticosterone	57-71	cortistatin	Rattus norvegicus	73-77
21870155-3	2012	The aim of this work was to study the acute effects of ethanol (2.5 g/kg) on enkephalinase (NEP) and aminopeptidase N (APN) activities and expression in regions of the mesocorticolimbic system, as well as on corticosterone levels in serum for up to 24 h after administration.	Corticosterone	208-222	alanyl aminopeptidase, membrane	Homo sapiens	119-122
22641130-3	2012	Proliferation of cultured astrocytes was reduced following treatment with corticosterone and dexamethasone for 72 h. Corticosterone and dexamethasone also reduced GR expression in astrocytes.	Corticosterone	74-88	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	163-165
22641130-3	2012	Proliferation of cultured astrocytes was reduced following treatment with corticosterone and dexamethasone for 72 h. Corticosterone and dexamethasone also reduced GR expression in astrocytes.	Corticosterone	117-131	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	163-165
23406756-8	2012	RESULTS: IL-1beta significantly increased plasma ACTH, corticosterone and IL-1beta levels during 2 h after ip administration.	Corticosterone	55-69	interleukin 1 beta	Rattus norvegicus	9-17
23226485-8	2012	Linear regression showed that IL-2, IL-6 and IL-12 levels predicted 66% of corticosterone levels, which were selectively increased in psoriasis mice subject to PSD.	Corticosterone	75-89	interleukin 2	Mus musculus	30-34
23226485-8	2012	Linear regression showed that IL-2, IL-6 and IL-12 levels predicted 66% of corticosterone levels, which were selectively increased in psoriasis mice subject to PSD.	Corticosterone	75-89	interleukin 6	Mus musculus	36-40
23152847-4	2012	Three hours after onset of EIU, the MR and the glucocorticoid metabolizing enzyme 11-beta hydroxysteroid dehydrogenase type 2 (11beta-HSD2) expression were down-regulated in iris/ciliary body and the corticosterone concentration was increased in aqueous humor, altering the normal MR/glucocorticoid receptor (GR) balance.	Corticosterone	200-214	nuclear receptor subfamily 3 group C member 2	Homo sapiens	36-38
23056375-7	2012	Endothelial cell proliferation was reduced in corticosterone treated cells, coinciding with elevated FoxO1 and reduced VEGF production.	Corticosterone	46-60	forkhead box O1	Rattus norvegicus	101-106
23056375-7	2012	Endothelial cell proliferation was reduced in corticosterone treated cells, coinciding with elevated FoxO1 and reduced VEGF production.	Corticosterone	46-60	vascular endothelial growth factor A	Rattus norvegicus	119-123
23056375-8	2012	Corticosterone treated endothelial cells exhibited reduced migration, which correlated with a reduction in RhoA activity.	Corticosterone	0-14	ras homolog family member A	Rattus norvegicus	107-111
23056375-9	2012	Furthermore, corticosterone treated endothelial cells in both 3-dimensional and monolayer cultures had decreased MMP-2 production and activation resulting in decreased proteolysis by endothelial cells, limiting their angiogenic potential.	Corticosterone	13-27	matrix metallopeptidase 2	Rattus norvegicus	113-118
23056375-10	2012	Promoter assays revealed that corticosterone treatment transcriptionally repressed MMP-2, which may map to a predicted GRE between -1510 and -1386 bp of the MMP-2 promoter.	Corticosterone	30-44	matrix metallopeptidase 2	Rattus norvegicus	83-88
23056375-10	2012	Promoter assays revealed that corticosterone treatment transcriptionally repressed MMP-2, which may map to a predicted GRE between -1510 and -1386 bp of the MMP-2 promoter.	Corticosterone	30-44	matrix metallopeptidase 2	Rattus norvegicus	157-162
23056375-11	2012	Additionally, Sp1, a known transcriptional activator of MMP-2 was decreased following corticosterone treatment.	Corticosterone	86-100	matrix metallopeptidase 2	Rattus norvegicus	56-61
23406756-9	2012	IL-1 receptor antagonist was able to abolish the stimulatory effect of IL-1beta on plasma ACTH and corticosterone levels and significantly, but not totally, reduced plasma IL-1beta level.	Corticosterone	99-113	interleukin 1 receptor antagonist	Rattus norvegicus	0-24
23406756-9	2012	IL-1 receptor antagonist was able to abolish the stimulatory effect of IL-1beta on plasma ACTH and corticosterone levels and significantly, but not totally, reduced plasma IL-1beta level.	Corticosterone	99-113	interleukin 1 beta	Rattus norvegicus	71-79
22952879-6	2012	We presently found that the JNK antagonist, SP600125, (but not the p38 antagonist, SB203580) increased plasma corticosterone levels under resting conditions and in the context of an acute stressor (wet bedding + restraint).	Corticosterone	110-124	mitogen-activated protein kinase 8	Homo sapiens	28-31
22192617-10	2011	CONCLUSIONS: Our study suggests that low maternal care alters corticosterone and 17beta-estradiol levels, disrupting the estrous cycle and folliculogenesis and differentially regulating the expression of ER-alpha and ER-beta in the ovaries of adult rats.	Corticosterone	62-76	estrogen receptor 1	Rattus norvegicus	204-212
23029379-3	2012	Here, we tested the hypothesis that increased levels of the stress-associated hormone corticosterone (CORT) would increase epileptiform activity and spontaneous seizure frequency in mice rendered epileptic following pilocarpine-induced status epilepticus.	Corticosterone	86-100	cortistatin	Mus musculus	102-106
22761903-2	2012	Placental 11beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) buffers the impact of maternal glucocorticoid exposure by converting cortisol/corticosterone into inactive metabolites.	Corticosterone	141-155	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	54-61
22701737-1	2012	Many studies have shown that chronic stress or corticosterone over-exposure in rodents leads to extensive dendritic remodeling, particularly of principal neurons in the CA3 hippocampal area and the basolateral amygdala.	Corticosterone	47-61	carbonic anhydrase 3	Mus musculus	169-172
22509272-2	2012	Exposure to acute stress induces corticosterone (CORT) secretion from the adrenal cortex, resulting in rapid increase of CORT levels in plasma and the hippocampus.	Corticosterone	33-47	cortistatin	Rattus norvegicus	49-53
22509272-2	2012	Exposure to acute stress induces corticosterone (CORT) secretion from the adrenal cortex, resulting in rapid increase of CORT levels in plasma and the hippocampus.	Corticosterone	33-47	cortistatin	Rattus norvegicus	121-125
22192617-10	2011	CONCLUSIONS: Our study suggests that low maternal care alters corticosterone and 17beta-estradiol levels, disrupting the estrous cycle and folliculogenesis and differentially regulating the expression of ER-alpha and ER-beta in the ovaries of adult rats.	Corticosterone	62-76	estrogen receptor 2	Rattus norvegicus	217-224
21945397-3	2011	The key to the intracellular activation of glucocorticoids in adipocytes is 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which catalyses the production of active glucocorticoids (cortisol in humans and corticosterone in rodents) from an inactive 11-keto form (cortisone in humans and 11-dehydrocorticosterone in rodents).	Corticosterone	215-229	RNA, U1 small nuclear 1	Homo sapiens	76-131
22041182-8	2011	In accordance with a physiological role for SK4 channels in vivo, restraint stress-induced plasma ACTH and corticosterone concentrations were significantly enhanced in gene-targeted mice lacking SK4 channels (Kcnn4(-/-)).	Corticosterone	107-121	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	44-47
22041182-8	2011	In accordance with a physiological role for SK4 channels in vivo, restraint stress-induced plasma ACTH and corticosterone concentrations were significantly enhanced in gene-targeted mice lacking SK4 channels (Kcnn4(-/-)).	Corticosterone	107-121	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	209-214
22170608-4	2011	In mice, genetic loss of cryptochrome 1 and/or 2 results in glucose intolerance and constitutively high levels of circulating corticosterone, suggesting reduced suppression of the hypothalamic-pituitary-adrenal axis coupled with increased glucocorticoid transactivation in the liver.	Corticosterone	126-140	cryptochrome 1 (photolyase-like)	Mus musculus	25-39
23159867-6	2012	Both male and female adolescent offspring of corticosterone (CORT) supplemented dams (CORT-nursed) showed an increase in social play behavior (i.e., pinning, pouncing, wrestling/boxing and social exploration) when compared to controls.	Corticosterone	45-59	cortistatin	Rattus norvegicus	61-65
23159867-6	2012	Both male and female adolescent offspring of corticosterone (CORT) supplemented dams (CORT-nursed) showed an increase in social play behavior (i.e., pinning, pouncing, wrestling/boxing and social exploration) when compared to controls.	Corticosterone	45-59	cortistatin	Rattus norvegicus	86-90
21627635-12	2011	Ucn 1, but not Ucn 2, also increased corticosterone levels.	Corticosterone	37-51	urocortin	Rattus norvegicus	0-3
21962440-7	2011	PDE8B modulates basal corticosterone synthesis via acute and chronic mechanisms.	Corticosterone	22-36	phosphodiesterase 8B	Homo sapiens	0-5
22010640-1	2011	Mineralocorticoid receptor is the receptor for corticosteroids such as corticosterone or aldosterone.	Corticosterone	71-85	mineralocorticoid receptor	Melopsittacus undulatus	0-26
22105169-9	2011	In athymic nude mice, EGFR overexpression enhanced the growth of explanted ACTH-secreting tumors and further elevated serum corticosterone levels.	Corticosterone	124-138	epidermal growth factor receptor	Mus musculus	22-26
21910766-7	2011	Interestingly, plasma concentrations of both corticosterone (CORT) and adrenocorticotrophin hormone (ACTH) during the resting condition decreased in STX1A KO mice compared to WT mice.	Corticosterone	45-59	syntaxin 1A (brain)	Mus musculus	149-154
22084082-5	2011	Npy1r(rfb) mutants also had a hyperactive hypothalamic-pituitary-adrenocortical axis, as indicated by higher peripheral corticosterone and higher density of NPY immunoreactive fibers and corticotropin releasing hormone immunoreactive cell bodies in the paraventricular hypothalamic nucleus.	Corticosterone	120-134	neuropeptide Y receptor Y1	Mus musculus	0-5
21878341-7	2011	The influence of corticosterone on UCP2 expression of splenocytes was analyzed by Western blot.	Corticosterone	17-31	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	35-39
21878341-9	2011	The corticosterone response after SDR+EPM was reduced in UCP2-deficient mice compared to wildtype mice.	Corticosterone	4-18	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	57-61
21878341-10	2011	Corticosterone in turn downregulates UCP2 expression in splenocyte cultures of wildtype mice at physiological concentrations.	Corticosterone	0-14	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	37-41
21959177-0	2011	The CRH-R1 receptor mediates luteinizing hormone, prolactin, corticosterone and progesterone secretion induced by restraint stress in estrogen-primed rats.	Corticosterone	61-75	corticotropin releasing hormone receptor 1	Rattus norvegicus	4-10
21910768-3	2011	In the present study, we examined the effects of acute exposure to corticosterone (CORT) at the level of the paraventricular nucleus (PVN) on the HPA axis response to a subsequent stressor in a short-term (1 h) timeframe.	Corticosterone	67-81	cortistatin	Homo sapiens	83-87
21929693-1	2011	The negative-feedback actions of corticosterone (CORT) depend on both phasic and tonic CORT secretion patterns to regulate hypothalamic-pituitary-adrenal (HPA) axis activity.	Corticosterone	33-47	cortistatin	Rattus norvegicus	49-53
21929693-1	2011	The negative-feedback actions of corticosterone (CORT) depend on both phasic and tonic CORT secretion patterns to regulate hypothalamic-pituitary-adrenal (HPA) axis activity.	Corticosterone	33-47	cortistatin	Rattus norvegicus	87-91
21377501-10	2011	When LPS administration was combined with ghrelin fever was attenuated, corticosterone secretion further increased, and the elevated preoptic PGE(2) levels were relatively reduced, but a correlation between these two variables (corticosterone and PGE(2)) failed to exist.	Corticosterone	228-242	ghrelin and obestatin prepropeptide	Rattus norvegicus	42-49
21643998-4	2011	The effects of acupuncture on the activation of stress were measured by assessing plasma levels of corticosterone (CORT) and adrenocorticotropin hormone (ACTH).	Corticosterone	99-113	cortistatin	Rattus norvegicus	115-119
21625958-5	2011	Serum corticosterone (CORT) was monitored as an indicator of the stress response.	Corticosterone	6-20	cortistatin	Rattus norvegicus	22-26
21907418-2	2011	Both corticosterone (CORT) and laparotomy cause sensitization, leading to enhanced sickness-induced neuroinflammation or pain (respectively).	Corticosterone	5-19	cortistatin	Homo sapiens	21-25
21542833-7	2011	In mice with thioglycollate-induced peritonitis, both 5alphaTHB and corticosterone reduced the numbers of neutrophils (58.6%, 49.9%) and inflammatory monocytes (69.5%, 96.4%), and also suppressed MCP-1 (48.7%, 80.9%) and IL-6 (53.5%, 86.7%) in peritoneal exudate.	Corticosterone	68-82	mast cell protease 1	Mus musculus	196-201
21542833-7	2011	In mice with thioglycollate-induced peritonitis, both 5alphaTHB and corticosterone reduced the numbers of neutrophils (58.6%, 49.9%) and inflammatory monocytes (69.5%, 96.4%), and also suppressed MCP-1 (48.7%, 80.9%) and IL-6 (53.5%, 86.7%) in peritoneal exudate.	Corticosterone	68-82	interleukin 6	Mus musculus	221-225
21542833-8	2011	In mice chronically infused with 5alphaTHB and corticosterone LPS-induced production of TNF-alpha from whole blood was suppressed to the same degree (63.2%, 37.2%).	Corticosterone	47-61	tumor necrosis factor	Mus musculus	88-97
21814183-7	2011	However, Reelin overexpression in the mouse forebrain reduced the time spent floating in the forced-swim-test in mice subjected to chronic corticosterone treatment, reduced behavioral sensitization to cocaine, and reduced PPI deficits induced by a NMDA antagonist.	Corticosterone	139-153	reelin	Mus musculus	9-15
21620900-5	2011	We have previously shown that male Nrg1(Tn) rats have increased basal corticosterone levels, and fail to habituate to an open field despite normal overall levels of locomotor activity.	Corticosterone	70-84	neuregulin 1	Rattus norvegicus	35-39
21620900-6	2011	The current studies show that, in contrast, female Nrg1(Tn) rats exhibit enhanced suppression of corticosterone levels following an acute stress, reduced locomotor activity, and enhanced habituation to novel environments.	Corticosterone	97-111	neuregulin 1	Rattus norvegicus	51-55
22016534-5	2011	Inhibition of AT1R specifically within the SFO blunted the release of adrenocorticotrophin-releasing hormone and corticosterone in response to restraint stress and caused rats to spend more time in the open arms of an elevated-plus maze than controls, indicating that inhibition of AT1R within the SFO is anxiolytic.	Corticosterone	113-127	angiotensin II receptor, type 1a	Rattus norvegicus	14-18
21807067-3	2011	This high level of production of corticosterone plays an important role in altering the predisposition to EAE-induced neuroinflammation, as a positive correlation occurred between the concentration of urine corticosterone and the increased apoptotic CD4(+) T cells from the peripheral blood.	Corticosterone	33-47	Cd4 molecule	Rattus norvegicus	250-253
21807067-3	2011	This high level of production of corticosterone plays an important role in altering the predisposition to EAE-induced neuroinflammation, as a positive correlation occurred between the concentration of urine corticosterone and the increased apoptotic CD4(+) T cells from the peripheral blood.	Corticosterone	207-221	Cd4 molecule	Rattus norvegicus	250-253
21722764-6	2011	RESULTS: CS suppressed serum OCN levels in WT and tg mice, although they remained higher in tg animals at all time points (p&lt;0.05).	Corticosterone	9-11	bone gamma-carboxyglutamate protein 2	Mus musculus	29-32
21536123-2	2011	Corticosterone (CORT) primes rat immune cells, exacerbating pro-inflammatory responses to subsequent immune challenges.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
21828178-8	2011	Thus, the increase in circulating CBG levels after stress restrains the rise in free corticosterone concentrations for approximately 20 min in the face of mounting total hormone levels in the circulation.	Corticosterone	85-99	serpin family A member 6	Rattus norvegicus	34-37
21704088-3	2011	A sharp and short-lasting increase in the gene expression of a set of stress-related genes previously reported, e.g., Fos and Nr4a1, was observed during the stress, with a similar pattern of changes in corticosterone.	Corticosterone	202-216	FBJ osteosarcoma oncogene	Mus musculus	118-121
21704088-3	2011	A sharp and short-lasting increase in the gene expression of a set of stress-related genes previously reported, e.g., Fos and Nr4a1, was observed during the stress, with a similar pattern of changes in corticosterone.	Corticosterone	202-216	nuclear receptor subfamily 4, group A, member 1	Mus musculus	126-131
21742037-6	2011	Since the affected isoforms (CYP1A/2B/2C11/3A) are regulated by endogenous hormones (growth hormone, corticosterone, thyroid hormones), the latter being under control of the central nervous system, it is postulated that the brain noradrenergic and serotonergic systems are involved in the physiological regulation of liver CYP expression.	Corticosterone	101-115	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	29-32
21729739-5	2011	The results showed that CMS led to more severe depressive responses in UCP2 knockout mice, characterized by exacerbated depression-like behaviors, increased corticosterone level and significant loss of weight.	Corticosterone	157-171	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	71-75
22832658-6	2011	Notably, Cnp1(KO) mice were less vulnerable to developing a depressive-like syndrome after either UCMS or chronic corticosterone exposure.	Corticosterone	114-128	2',3'-cyclic nucleotide 3' phosphodiesterase	Mus musculus	9-13
21856283-5	2011	Notably REDD1 expression in skeletal muscle positively correlated with changes in corticosterone concentrations in all conditions.	Corticosterone	82-96	DNA-damage-inducible transcript 4	Mus musculus	8-13
21900567-7	2011	Our results thus characterize the presence of latent vulnerability traits that underlie the emergence of depression and identify the association of low BDNF with normal corticosterone serum concentrations as a predictive biomarker of vulnerability to depression.	Corticosterone	169-183	brain derived neurotrophic factor	Homo sapiens	152-156
21484271-6	2011	Consistent with this, the homeostatic serum level of corticosterone in Fpr1 (-/-) mice was significantly lower compared with wild-type mice.	Corticosterone	53-67	formyl peptide receptor 1	Mus musculus	71-75
21325249-3	2011	In this study, exogenous administration of recombinant mouse macrophage migration inhibitory factor (rMIF), at a dose close to the levels found in the blood of sepsis patients, significantly enhanced serum corticosterone concentration but neither altered circulatory function nor stimulated nitric oxide (NO) release in rats.	Corticosterone	206-220	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	61-99
21325249-3	2011	In this study, exogenous administration of recombinant mouse macrophage migration inhibitory factor (rMIF), at a dose close to the levels found in the blood of sepsis patients, significantly enhanced serum corticosterone concentration but neither altered circulatory function nor stimulated nitric oxide (NO) release in rats.	Corticosterone	206-220	macrophage migration inhibitory factor	Rattus norvegicus	101-105
21798262-3	2011	Given that the oEPM seems to be a more aversive situation than the sEPM, we hypothesized that oEPM exposure would induce higher plasma levels of corticosterone than sEPM exposure in mice.	Corticosterone	145-159	selenoprotein M	Mus musculus	67-71
21359952-5	2011	of corticosterone daily to rats for 7 days resulted in the upregulation of IRP-1 and transferrin receptor-1 and accumulation of iron in liver.	Corticosterone	3-17	aconitase 1	Rattus norvegicus	75-80
21798262-7	2011	All three types of EPM exposure increased plasma corticosterone when compared to the basal group, but sEPM- and oEPM-exposed mice showed higher corticosterone levels than eEPM-exposed mice.	Corticosterone	144-158	selenoprotein M	Mus musculus	102-106
21801726-0	2011	Male rats with the testicular feminization mutation of the androgen receptor display elevated anxiety-related behavior and corticosterone response to mild stress.	Corticosterone	123-137	androgen receptor	Rattus norvegicus	59-76
21820440-5	2011	It has been observed that TI is more prolonged in stressed animals, and systemic injection of corticosterone (CORT) also potentiates this behavior.	Corticosterone	94-108	cortistatin	Rattus norvegicus	110-114
21792578-2	2011	It has been shown in some studies that the rise in corticosterone (CORT) concentration is indispensable for both the induction and the expression of behavioral sensitization.	Corticosterone	51-65	cortistatin	Rattus norvegicus	67-71
21932173-9	2011	Serum corticosterone was higher (+ 77%) in male NIC group, coherent with the increase of both CRH and ACTH immunostaining in hypothalamus and pituitary, respectively.	Corticosterone	6-20	corticotropin releasing hormone	Rattus norvegicus	94-97
21730055-8	2011	ERK inhibitors reversed MW and MW plus corticosterone inhibition of LPS-induced IL-12p40.	Corticosterone	39-53	interleukin 12b	Mus musculus	80-88
21824204-3	2011	Pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in central control of the HPA axis, and we have recently shown PACAP-dependent expression of corticotropin-releasing hormone (CRH) and secretion of corticosterone in response to restraint.	Corticosterone	227-241	adenylate cyclase activating polypeptide 1	Mus musculus	0-58
21824204-3	2011	Pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in central control of the HPA axis, and we have recently shown PACAP-dependent expression of corticotropin-releasing hormone (CRH) and secretion of corticosterone in response to restraint.	Corticosterone	227-241	adenylate cyclase activating polypeptide 1	Mus musculus	52-57
21824204-3	2011	Pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in central control of the HPA axis, and we have recently shown PACAP-dependent expression of corticotropin-releasing hormone (CRH) and secretion of corticosterone in response to restraint.	Corticosterone	227-241	corticotropin releasing hormone	Mus musculus	172-203
21824204-3	2011	Pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in central control of the HPA axis, and we have recently shown PACAP-dependent expression of corticotropin-releasing hormone (CRH) and secretion of corticosterone in response to restraint.	Corticosterone	227-241	corticotropin releasing hormone	Mus musculus	205-208
21092742-9	2011	In support of this hypothesis, Nrg1(Tn) rats have disrupted basal and acute stress recovery corticosterone secretion, differential changes in expression of glucocorticoid receptors in the pituitary, paraventricular nucleus and hippocampus, and a failure to habituate to an open field.	Corticosterone	92-106	neuregulin 1	Rattus norvegicus	31-35
21438773-0	2011	PACAP centrally mediates emotional stress-induced corticosterone responses in mice.	Corticosterone	50-64	adenylate cyclase activating polypeptide 1	Mus musculus	0-5
21254899-14	2011	We propose that deletion of GRPR leads to the induction of depression-like behavior which is paralleled by dysregulation of amygdala gene expression, potentially resulting from deficient light-induced corticosterone release in GRPR-KO.	Corticosterone	201-215	gastrin releasing peptide receptor	Mus musculus	28-32
21254899-14	2011	We propose that deletion of GRPR leads to the induction of depression-like behavior which is paralleled by dysregulation of amygdala gene expression, potentially resulting from deficient light-induced corticosterone release in GRPR-KO.	Corticosterone	201-215	gastrin releasing peptide receptor	Mus musculus	227-231
21796698-4	2011	Treatment with corticosterone alone resulted in a significant decrease in hippocampus neurofilament light chain (NF-L) protein expression and induced depression-like behavior.	Corticosterone	15-29	neurofilament, light polypeptide	Mus musculus	113-117
21190219-0	2011	Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain.	Corticosterone	8-22	discs large MAGUK scaffold protein 4	Mus musculus	70-76
21190219-0	2011	Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain.	Corticosterone	8-22	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	78-81
21190219-0	2011	Chronic corticosterone exposure alters postsynaptic protein levels of PSD-95, NR1, and synaptopodin in the mouse brain.	Corticosterone	8-22	synaptopodin	Mus musculus	87-99
21775596-9	2011	These data support a model in which endocannabinoid signaling links glucocorticoid receptor engagement to activation of corticolimbic relays that inhibit corticosterone secretion.	Corticosterone	154-168	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	68-91
21771319-9	2011	Most importantly, the maternal LPS challenge caused corticosterone-independent blunting of the serum proinflammatory cytokine response to innate immune challenge in both male and female offspring.	Corticosterone	52-66	toll-like receptor 4	Mus musculus	31-34
21605667-8	2011	Co-incubation with the OCT1 inhibitor prazosin (3 muM) and the OCT3 inhibitor corticosterone (1 muM) resulted in a significant (p&lt;0.01) decrease to 72% and 85% of the accumulation in control conditions, respectively.	Corticosterone	78-92	solute carrier family 22 member 1	Homo sapiens	23-27
21605667-8	2011	Co-incubation with the OCT1 inhibitor prazosin (3 muM) and the OCT3 inhibitor corticosterone (1 muM) resulted in a significant (p&lt;0.01) decrease to 72% and 85% of the accumulation in control conditions, respectively.	Corticosterone	78-92	solute carrier family 22 member 3	Homo sapiens	63-67
21773966-4	2011	Moreover, the plasma corticosterone and aldosterone were higher in Homer 1 KO than wild-type (WT) mice while the plasma ACTH levels were not different between the genotypes.	Corticosterone	21-35	homer scaffolding protein 1	Mus musculus	67-74
21773966-5	2011	The in vivo ACTH test revealed that corticosterone and aldosterone plasma levels were higher in saline injected Homer 1 KO mice than in WT mice (saline injected mice served as controls for the respective groups of ACTH-injected animals), but the magnitude of steroid responses to ACTH was similar in both genotypes.	Corticosterone	36-50	pro-opiomelanocortin-alpha	Mus musculus	12-16
21773966-5	2011	The in vivo ACTH test revealed that corticosterone and aldosterone plasma levels were higher in saline injected Homer 1 KO mice than in WT mice (saline injected mice served as controls for the respective groups of ACTH-injected animals), but the magnitude of steroid responses to ACTH was similar in both genotypes.	Corticosterone	36-50	homer scaffolding protein 1	Mus musculus	112-119
21689105-3	2011	Exposure of cortical neurons to corticosterone results in decreased mRNA levels for three 5-HT receptor subtypes, 5-HT(1A), 5-HT(2A) and 5-HT(4), but 5-HT(1B,) 5-HT(2B), 5-HT(2C), 5-HT(6) and 5-HT(7) receptors remain unchanged.	Corticosterone	32-46	5-hydroxytryptamine receptor 1A	Homo sapiens	114-121
21689105-3	2011	Exposure of cortical neurons to corticosterone results in decreased mRNA levels for three 5-HT receptor subtypes, 5-HT(1A), 5-HT(2A) and 5-HT(4), but 5-HT(1B,) 5-HT(2B), 5-HT(2C), 5-HT(6) and 5-HT(7) receptors remain unchanged.	Corticosterone	32-46	5-hydroxytryptamine receptor 2A	Homo sapiens	124-131
21689105-7	2011	Curcumin was also found to regulate corticosterone-induced morphological changes such as increases in soma size, dendritic branching and dendritic spine density, as well as elevate synaptophysin expression in cortical neurons.	Corticosterone	36-50	synaptophysin	Homo sapiens	181-194
21689105-8	2011	p-MPPI and RS 39604 reversed the effect of curcumin-induced change in neuronal morphology and synaptophysin expression of corticosterone-treated neurons.	Corticosterone	122-136	synaptophysin	Homo sapiens	94-107
21438773-2	2011	Recently, PACAP was shown to be involved in restraint stress-induced corticosterone release and concomitant expression of the genes involved in hypothalamic-pituitary-adrenal (HPA) axis activation.	Corticosterone	69-83	adenylate cyclase activating polypeptide 1	Mus musculus	10-15
21438773-4	2011	Among four different types of stressors, open-field exposure, cold exposure, ether inhalation, and restraint, the corticosterone response to open-field exposure and restraint, which are categorized as emotional stressors, but not the other two, was markedly attenuated in PACAP-/- mice.	Corticosterone	114-128	adenylate cyclase activating polypeptide 1	Mus musculus	272-280
21438773-5	2011	Peripheral administration of corticotropin releasing factor (CRF) or adrenocorticotropic hormone induced corticosterone increase similarly in PACAP-/- and wild-type mice.	Corticosterone	105-119	corticotropin releasing hormone	Mus musculus	29-59
21377524-4	2011	In support of this view, prior TNFalpha microinjection into the central amygdala (CeA) of rats facilitated ethanol withdrawal-induced anxiety-a response that could not be attributed to an increase in plasma corticosterone.	Corticosterone	207-221	tumor necrosis factor	Rattus norvegicus	31-39
21615389-8	2011	In contrast, PKC inhibition reduced the withdrawal-triggered rise in pCREB, pERK1/2 and corticosterone secretion.	Corticosterone	88-102	protein kinase C, gamma	Rattus norvegicus	13-16
21382475-5	2011	Treatment with glucocorticoid (corticosterone) and Abeta in SH-SY5Y cells increased the expression of 17beta-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells suppressed glucocorticoid-enhanced mitochondrial dysfunction and ROS accumulation.	Corticosterone	31-45	hydroxysteroid 17-beta dehydrogenase 13	Homo sapiens	102-137
21382475-5	2011	Treatment with glucocorticoid (corticosterone) and Abeta in SH-SY5Y cells increased the expression of 17beta-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells suppressed glucocorticoid-enhanced mitochondrial dysfunction and ROS accumulation.	Corticosterone	31-45	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	139-143
21382475-5	2011	Treatment with glucocorticoid (corticosterone) and Abeta in SH-SY5Y cells increased the expression of 17beta-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells suppressed glucocorticoid-enhanced mitochondrial dysfunction and ROS accumulation.	Corticosterone	31-45	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	212-216
21382475-5	2011	Treatment with glucocorticoid (corticosterone) and Abeta in SH-SY5Y cells increased the expression of 17beta-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells suppressed glucocorticoid-enhanced mitochondrial dysfunction and ROS accumulation.	Corticosterone	31-45	hydroxysteroid 17-beta dehydrogenase 10	Homo sapiens	212-216
21315785-11	2011	In female mice, however, corticosterone does appear to mediate the persistent effects of acute ethanol administration on poly I:C- induced IL-6 levels.	Corticosterone	25-39	interleukin 6	Mus musculus	139-143
21514337-1	2011	Ghrelin, the endogenous ligand for growth hormone secretagogues (GHSs) receptor (GHS-R), increases adrenocorticotropin (ACTH) and cortisol (corticosterone) as well as GH secretion in humans and animals.	Corticosterone	140-154	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
21458468-1	2011	Steroid 11beta-hydroxylase (CYP11B1; EC 1.14.15.4) is a mitochondrial enzyme located in the zona fasciculata of the adrenal cortex and also in the brain that mediates the conversion of 11-deoxycortisol to cortisol and 11-deoxycorticosterone (DOC) to corticosterone.	Corticosterone	226-240	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	0-26
21458468-1	2011	Steroid 11beta-hydroxylase (CYP11B1; EC 1.14.15.4) is a mitochondrial enzyme located in the zona fasciculata of the adrenal cortex and also in the brain that mediates the conversion of 11-deoxycortisol to cortisol and 11-deoxycorticosterone (DOC) to corticosterone.	Corticosterone	226-240	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	28-35
21122919-3	2011	To address this issue, the present study examines how chronic corticosterone (CORT) administration during adolescence and early adulthood influences depression-like behaviors, hypothalamic-pituitary-adrenal (HPA) axis response and hippocampal cell proliferation.	Corticosterone	62-76	cortistatin	Mus musculus	78-82
21860595-6	2011	In addition, in brain slices incubated with corticosterone together with RU486 (MR-dominant group), the proportion of neurons showing a burst firing pattern was significantly higher than those in the slices incubated with vehicle, corticosterone, or corticosterone with spironolactone (GR-dominant group; 64 vs. 11~14%, p&lt; 0.01 by chi(2)-test).	Corticosterone	44-58	nuclear receptor subfamily 3, group C, member 2	Mus musculus	80-82
21860595-6	2011	In addition, in brain slices incubated with corticosterone together with RU486 (MR-dominant group), the proportion of neurons showing a burst firing pattern was significantly higher than those in the slices incubated with vehicle, corticosterone, or corticosterone with spironolactone (GR-dominant group; 64 vs. 11~14%, p&lt; 0.01 by chi(2)-test).	Corticosterone	44-58	nuclear receptor subfamily 3, group C, member 1	Mus musculus	286-288
21860595-6	2011	In addition, in brain slices incubated with corticosterone together with RU486 (MR-dominant group), the proportion of neurons showing a burst firing pattern was significantly higher than those in the slices incubated with vehicle, corticosterone, or corticosterone with spironolactone (GR-dominant group; 64 vs. 11~14%, p&lt; 0.01 by chi(2)-test).	Corticosterone	231-245	nuclear receptor subfamily 3, group C, member 2	Mus musculus	80-82
21860595-6	2011	In addition, in brain slices incubated with corticosterone together with RU486 (MR-dominant group), the proportion of neurons showing a burst firing pattern was significantly higher than those in the slices incubated with vehicle, corticosterone, or corticosterone with spironolactone (GR-dominant group; 64 vs. 11~14%, p&lt; 0.01 by chi(2)-test).	Corticosterone	231-245	nuclear receptor subfamily 3, group C, member 2	Mus musculus	80-82
21514337-1	2011	Ghrelin, the endogenous ligand for growth hormone secretagogues (GHSs) receptor (GHS-R), increases adrenocorticotropin (ACTH) and cortisol (corticosterone) as well as GH secretion in humans and animals.	Corticosterone	140-154	growth hormone secretagogue receptor	Homo sapiens	81-86
21385938-7	2011	These regions are important for inhibitory influences on the PVN, and accordingly, hippocampal c-Fos levels were negatively correlated with corticosterone production.	Corticosterone	140-154	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
20849864-1	2011	We examined a potential two-hit murine animal model of depression by assessing whether a genetic deficit in reelin increases vulnerability to the depressogenic effects of the stress hormone corticosterone.	Corticosterone	190-204	reelin	Mus musculus	108-114
20849864-6	2011	Corticosterone produced dose-dependent increases in depression-like behavior and decreases in reelin expression, neurogenesis, and cell maturation regardless of mouse genotype.	Corticosterone	0-14	reelin	Mus musculus	94-100
21613472-5	2011	More importantly, nNOS deletion or intrahippocampal nNOS inhibition and NO-cGMP signaling blockade (using NO scavenger or sGC inhibitor) prevented the corticosterone-induced behavioral modifications, suggesting that hippocampal nNOS is necessary for the role of glucocorticoids in mediating depressive behaviors.	Corticosterone	151-165	nitric oxide synthase 1	Homo sapiens	18-22
21613472-5	2011	More importantly, nNOS deletion or intrahippocampal nNOS inhibition and NO-cGMP signaling blockade (using NO scavenger or sGC inhibitor) prevented the corticosterone-induced behavioral modifications, suggesting that hippocampal nNOS is necessary for the role of glucocorticoids in mediating depressive behaviors.	Corticosterone	151-165	nitric oxide synthase 1	Homo sapiens	52-56
21613472-5	2011	More importantly, nNOS deletion or intrahippocampal nNOS inhibition and NO-cGMP signaling blockade (using NO scavenger or sGC inhibitor) prevented the corticosterone-induced behavioral modifications, suggesting that hippocampal nNOS is necessary for the role of glucocorticoids in mediating depressive behaviors.	Corticosterone	151-165	nitric oxide synthase 1	Homo sapiens	52-56
21371532-4	2011	This study investigated how the stress hormone corticosterone (CORT) affects neuronal cells.	Corticosterone	47-61	cortistatin	Rattus norvegicus	63-67
20940090-10	2011	In light of the previously reported high corticosterone levels during postnatal development in GR(POMCCre) mice, our findings suggest that adverse early life events may have beneficial developmental effects on the organism to improve stress coping later in life.	Corticosterone	41-55	nuclear receptor subfamily 3, group C, member 1	Mus musculus	95-97
21262246-9	2011	Finally, statistical analysis showed a strong relation between MCP-1 expression levels in retroperitoneal WAT, fecal corticosterone and total WAT.	Corticosterone	117-131	C-C motif chemokine ligand 2	Rattus norvegicus	63-68
21352843-6	2011	In contrast, corticosterone stimulated the expression of C/EBPbeta and C/EBPdelta, but the levels of C/EBPalpha and C/EBPzeta were not changed.	Corticosterone	13-27	CCAAT/enhancer binding protein beta	Rattus norvegicus	57-66
21352843-6	2011	In contrast, corticosterone stimulated the expression of C/EBPbeta and C/EBPdelta, but the levels of C/EBPalpha and C/EBPzeta were not changed.	Corticosterone	13-27	CCAAT/enhancer binding protein delta	Rattus norvegicus	71-81
21362454-6	2011	Half-recovery time of GR was longer than that of MR in the presence of 10(-6)M corticosterone (CORT), but shorter in the presence of 10(-9)M CORT.	Corticosterone	79-93	nuclear receptor subfamily 3 group C member 1	Homo sapiens	22-24
21362454-6	2011	Half-recovery time of GR was longer than that of MR in the presence of 10(-6)M corticosterone (CORT), but shorter in the presence of 10(-9)M CORT.	Corticosterone	79-93	nuclear receptor subfamily 3 group C member 2	Homo sapiens	49-51
21362454-6	2011	Half-recovery time of GR was longer than that of MR in the presence of 10(-6)M corticosterone (CORT), but shorter in the presence of 10(-9)M CORT.	Corticosterone	95-99	nuclear receptor subfamily 3 group C member 1	Homo sapiens	22-24
21362454-6	2011	Half-recovery time of GR was longer than that of MR in the presence of 10(-6)M corticosterone (CORT), but shorter in the presence of 10(-9)M CORT.	Corticosterone	95-99	nuclear receptor subfamily 3 group C member 2	Homo sapiens	49-51
21362454-6	2011	Half-recovery time of GR was longer than that of MR in the presence of 10(-6)M corticosterone (CORT), but shorter in the presence of 10(-9)M CORT.	Corticosterone	141-145	nuclear receptor subfamily 3 group C member 1	Homo sapiens	22-24
21295352-8	2011	Corticosterone diet was associated with reduced CXCLi2 expression in heterophils from both lines.	Corticosterone	0-14	interleukin 8-like 2	Gallus gallus	48-54
21376725-2	2011	Experiment 1 characterized the effects of 10 min forebrain ischemia on corticosterone (CORT) secretion following ischemia and in response to spatial memory assessment in the Barnes maze, as well as the impact of pre-ischemia treatment with the glucocorticoid inhibitor metyrapone (175 mg/kg; s.c.).	Corticosterone	71-85	cortistatin	Rattus norvegicus	87-91
21185871-8	2011	Importantly, the increase of corticosterone level after escape or panic-like response was paralleled by an increase of neuronal activation of c-Fos in both the parvocellular and magnocellular paraventricular nucleus of the hypothalamus.	Corticosterone	29-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	142-147
21184805-4	2011	POMC null mutants born to heterozygous dams presented at birth with corticosterone levels no different from wildtype littermates, were euglycemic, and had normal liver glycogen stores.	Corticosterone	68-82	pro-opiomelanocortin-alpha	Mus musculus	0-4
21184805-9	2011	POMC null mutant mice born to POMC null mutant dams completely lack corticosterone and die of the expected respiratory dysfunction.	Corticosterone	68-82	pro-opiomelanocortin-alpha	Mus musculus	0-4
21184805-9	2011	POMC null mutant mice born to POMC null mutant dams completely lack corticosterone and die of the expected respiratory dysfunction.	Corticosterone	68-82	pro-opiomelanocortin-alpha	Mus musculus	30-34
21195129-7	2011	Mutation of the proximal SF-1-binding site results in down regulation of CYP11A1 in the adrenal and testis but not in the ovary and placenta, leading to attenuated corticosterone circadian rhythms and blunted stress response.	Corticosterone	164-178	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	73-80
21195130-4	2011	In contrast to POMC null mutant mice, mice lacking alpha-MSH in the presence of all other POMC peptides maintain adrenal structures and produce corticosterone comparable to wildtype littermates; however, they still have decreased levels of aldosterone, as found in POMC null mutant mice.	Corticosterone	144-158	pro-opiomelanocortin-alpha	Mus musculus	51-60
21170580-9	2011	These results suggest that the AV extract could generate a neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells, pointing to a possible action pathway by decreasing the Ca(2+) concentration and up-regulating BDNF and MAP4 genes.	Corticosterone	85-99	brain-derived neurotrophic factor	Rattus norvegicus	232-236
21170580-9	2011	These results suggest that the AV extract could generate a neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells, pointing to a possible action pathway by decreasing the Ca(2+) concentration and up-regulating BDNF and MAP4 genes.	Corticosterone	85-99	microtubule-associated protein 4	Rattus norvegicus	241-245
21216156-0	2011	Effects of hypothalamus destruction on the level of plasma corticosterone after blast injury and its relation to interleukin-6 in rats.	Corticosterone	59-73	interleukin 6	Rattus norvegicus	113-126
21216156-2	2011	The purpose of this study was to evaluate the dynamic relationship between plasma corticosterone and interleukin-6 in the hypothalamus-destroyed rats after blast injury.	Corticosterone	82-96	interleukin 6	Rattus norvegicus	101-114
21187369-3	2011	We demonstrate that PDE8B is highly enriched in mouse adrenal fasciculata cells, and show that PDE8B knockout mice have elevated urinary corticosterone as a result of adrenal hypersensitivity toward adrenocorticotropin.	Corticosterone	137-151	phosphodiesterase 8B	Mus musculus	20-25
21187369-3	2011	We demonstrate that PDE8B is highly enriched in mouse adrenal fasciculata cells, and show that PDE8B knockout mice have elevated urinary corticosterone as a result of adrenal hypersensitivity toward adrenocorticotropin.	Corticosterone	137-151	phosphodiesterase 8B	Mus musculus	95-100
21256829-7	2011	We found that WARs are smaller than Wistar and presented a higher adrenal gland weight with a higher level of corticosterone release after intravenous ACTH injection.	Corticosterone	110-124	tryptophanyl-tRNA synthetase 1	Rattus norvegicus	14-18
21303938-3	2011	MC2R(-/-) mice have undetectable levels of corticosterone despite high levels of ACTH and defects resembling those in patients with familial glucocorticoid deficiency.	Corticosterone	43-57	melanocortin 2 receptor	Mus musculus	0-4
21303938-7	2011	MC2R(-/-) pregnant females crossed with MC2R(+/+) males had detectable serum corticosterone levels, suggesting the transplacental passage of corticosterone from fetus to mother.	Corticosterone	77-91	melanocortin 2 receptor	Mus musculus	0-4
21303938-7	2011	MC2R(-/-) pregnant females crossed with MC2R(+/+) males had detectable serum corticosterone levels, suggesting the transplacental passage of corticosterone from fetus to mother.	Corticosterone	77-91	melanocortin 2 receptor	Mus musculus	40-44
21303938-7	2011	MC2R(-/-) pregnant females crossed with MC2R(+/+) males had detectable serum corticosterone levels, suggesting the transplacental passage of corticosterone from fetus to mother.	Corticosterone	141-155	melanocortin 2 receptor	Mus musculus	0-4
21303938-7	2011	MC2R(-/-) pregnant females crossed with MC2R(+/+) males had detectable serum corticosterone levels, suggesting the transplacental passage of corticosterone from fetus to mother.	Corticosterone	141-155	melanocortin 2 receptor	Mus musculus	40-44
21303938-12	2011	Exogenous corticosterone rescued expression of milk proteins in MC2R(-/-) mothers, and the pups of treated mothers grew to adulthood.	Corticosterone	10-24	melanocortin 2 receptor	Mus musculus	64-68
21111797-8	2011	The cytoprotection afforded by TGP treatment was associated with decreases in the intracellular ROS and MDA levels, and increases in the GSH level, SOD activity, and CAT activity in corticosterone-treated PC12 cells.	Corticosterone	182-196	catalase	Rattus norvegicus	166-169
21430148-7	2011	We found that hippocampal BDNF expression plays a critical role in resilience to chronic stress and that reduction of hippocampal BDNF expression in young, but not adult, rats induces prolonged elevations in corticosterone secretion.	Corticosterone	208-222	brain-derived neurotrophic factor	Rattus norvegicus	130-134
21223994-0	2011	Neonatal corticosterone administration impairs adult eyeblink conditioning and decreases glucocorticoid receptor expression in the cerebellar interpositus nucleus.	Corticosterone	9-23	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	89-112
21223994-4	2011	Therefore, effects of separation on GR expression in the interpositus and consequently adult eyeblink conditioning may be mediated by neonatal increases in corticosterone.	Corticosterone	156-170	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	36-38
21223994-12	2011	Neonatal corticosterone injections impaired adult eyeblink conditioning and decreased GR expression in the interpositus nucleus, while the effects of vehicle injections were intermediate.	Corticosterone	9-23	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	86-88
21223994-14	2011	This suggests an inverted U-shaped relationship may exist between both neonatal corticosterone levels and adult GR expression in the interpositus nucleus, and adult GR expression in the interpositus and eyeblink conditioning.	Corticosterone	80-94	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	112-114
21242794-0	2011	Endotoxin tolerance of adrenal gland: attenuation of corticosterone production in response to lipopolysaccharide and adrenocorticotropic hormone.	Corticosterone	53-67	proopiomelanocortin	Homo sapiens	117-144
21242794-10	2011	Plasma corticosterone response to ACTH was decreased in rats receiving preinjection of lipopolysaccharide.	Corticosterone	7-21	proopiomelanocortin	Homo sapiens	34-38
21242794-11	2011	Lipopolysaccharide pretreatment caused a significant decrease in corticosterone production in response to subsequent ACTH and lipopolysaccharide stimulation in primary fasciculata-reticularis cells.	Corticosterone	65-79	proopiomelanocortin	Homo sapiens	117-121
21242794-15	2011	In vitro, lipopolysaccharide pretreatment impaired corticosterone production of fasciculata-reticularis cells in response to ACTH and lipopolysaccharide, which was associated with decreased expression of synthetic enzymes required for corticosterone production.	Corticosterone	51-65	proopiomelanocortin	Homo sapiens	125-129
21242794-15	2011	In vitro, lipopolysaccharide pretreatment impaired corticosterone production of fasciculata-reticularis cells in response to ACTH and lipopolysaccharide, which was associated with decreased expression of synthetic enzymes required for corticosterone production.	Corticosterone	235-249	proopiomelanocortin	Homo sapiens	125-129
21248145-5	2011	Magel2-null mice had elevated basal corticosterone levels, and although male Magel2-null mice had an intact corticosterone response to restraint and to insulin-induced hypoglycemia, female Magel2-null mice failed to respond to hypoglycemia with increased corticosterone.	Corticosterone	36-50	MAGE family member L2	Mus musculus	0-6
21448312-2	2011	Corticosterone (CORT) actions in the brain are mediated via two receptor systems: the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
21448312-2	2011	Corticosterone (CORT) actions in the brain are mediated via two receptor systems: the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	86-109
21448312-2	2011	Corticosterone (CORT) actions in the brain are mediated via two receptor systems: the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	111-113
21448312-2	2011	Corticosterone (CORT) actions in the brain are mediated via two receptor systems: the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 2	Homo sapiens	123-149
21448312-2	2011	Corticosterone (CORT) actions in the brain are mediated via two receptor systems: the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 2	Homo sapiens	151-153
20717994-6	2011	Molecular analysis revealed corticosterone-induced increase in expression of stromal growth factor Fgf10 which, together with prominent stromal GR expression, suggest that glucocorticoid modify stromal-to-epithelial signaling in the mouse prostate.	Corticosterone	28-42	fibroblast growth factor 10	Mus musculus	99-104
20717994-6	2011	Molecular analysis revealed corticosterone-induced increase in expression of stromal growth factor Fgf10 which, together with prominent stromal GR expression, suggest that glucocorticoid modify stromal-to-epithelial signaling in the mouse prostate.	Corticosterone	28-42	nuclear receptor subfamily 3, group C, member 1	Mus musculus	144-146
20717994-7	2011	The mitogenic effects were prostate specific and not mediated by systemic effects on testosterone production suggesting that corticosterone effects were primarily mediated via prostate GR expression.	Corticosterone	125-139	nuclear receptor subfamily 3, group C, member 1	Mus musculus	185-187
20850956-4	2011	The carrageenan-induced paw edema was inhibited only when escin and corticosterone (Cort) were administered together.	Corticosterone	68-82	cortistatin	Mus musculus	84-88
21146591-1	2011	Corticosterone (CORT) release from the adrenal glands in response to acutely stressful stimuli is well-characterized, however several non-experimental, environmental stressors can also engender a CORT response.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
21146591-1	2011	Corticosterone (CORT) release from the adrenal glands in response to acutely stressful stimuli is well-characterized, however several non-experimental, environmental stressors can also engender a CORT response.	Corticosterone	0-14	cortistatin	Rattus norvegicus	196-200
21052977-8	2011	Incubation of mouse primary hepatocytes with corticosterone enhanced G6PT and H6PDH production with corresponding activation of 11beta-HSD1 and PEPCK: effects that were blocked by RU486.	Corticosterone	45-59	solute carrier family 37 (glucose-6-phosphate transporter), member 4	Mus musculus	69-73
21052977-8	2011	Incubation of mouse primary hepatocytes with corticosterone enhanced G6PT and H6PDH production with corresponding activation of 11beta-HSD1 and PEPCK: effects that were blocked by RU486.	Corticosterone	45-59	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	128-139
21052977-8	2011	Incubation of mouse primary hepatocytes with corticosterone enhanced G6PT and H6PDH production with corresponding activation of 11beta-HSD1 and PEPCK: effects that were blocked by RU486.	Corticosterone	45-59	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	144-149
21052977-9	2011	Knockdown of H6pd by small interfering RNA showed effects comparable with those of RU486 for attenuating the corticosterone-induced H6PDH production and 11ss-HSD1 reductase activity in these intact cells.	Corticosterone	109-123	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Mus musculus	13-17
21070780-0	2011	Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat.	Corticosterone	0-14	cannabinoid receptor 1	Rattus norvegicus	46-50
21070780-0	2011	Corticosterone mediates reciprocal changes in CB 1 and TRPV1 receptors in primary sensory neurons in the chronically stressed rat.	Corticosterone	0-14	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-60
21070780-9	2011	Control rats treated with serial injections of corticosterone in situ showed a significant increase in serum corticosterone associated with visceral hyperalgesia, enhanced anandamide content, increased TRPV1, and decreased CB1 receptor protein levels, which were prevented by co-treatment with RU-486.	Corticosterone	47-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	202-207
21182828-7	2011	Using western blot analysis, corticosterone activated p38MAPK, extracellular regulated kinase 1/2(ERK1/2) ,and c-jun N-terminal protein kinase 1(JNK1) ,while icariin blocked p38 MAPK, but not JNK1 or ERK1/2.	Corticosterone	29-43	mitogen activated protein kinase 3	Rattus norvegicus	98-104
21182828-7	2011	Using western blot analysis, corticosterone activated p38MAPK, extracellular regulated kinase 1/2(ERK1/2) ,and c-jun N-terminal protein kinase 1(JNK1) ,while icariin blocked p38 MAPK, but not JNK1 or ERK1/2.	Corticosterone	29-43	mitogen activated protein kinase 14	Rattus norvegicus	54-57
21182828-7	2011	Using western blot analysis, corticosterone activated p38MAPK, extracellular regulated kinase 1/2(ERK1/2) ,and c-jun N-terminal protein kinase 1(JNK1) ,while icariin blocked p38 MAPK, but not JNK1 or ERK1/2.	Corticosterone	29-43	mitogen activated protein kinase 3	Rattus norvegicus	200-206
21070780-9	2011	Control rats treated with serial injections of corticosterone in situ showed a significant increase in serum corticosterone associated with visceral hyperalgesia, enhanced anandamide content, increased TRPV1, and decreased CB1 receptor protein levels, which were prevented by co-treatment with RU-486.	Corticosterone	47-61	cannabinoid receptor 1	Rattus norvegicus	223-226
21070780-9	2011	Control rats treated with serial injections of corticosterone in situ showed a significant increase in serum corticosterone associated with visceral hyperalgesia, enhanced anandamide content, increased TRPV1, and decreased CB1 receptor protein levels, which were prevented by co-treatment with RU-486.	Corticosterone	109-123	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	202-207
21070780-10	2011	Exposure of isolated control L6-S2 DRGs in vitro to corticosterone reproduced the changes in CB1 and TRPV1 receptors observed in situ, which was prevented by co-treatment with RU-486 or WIN55,212-2.	Corticosterone	52-66	cannabinoid receptor 1	Rattus norvegicus	93-96
21070780-10	2011	Exposure of isolated control L6-S2 DRGs in vitro to corticosterone reproduced the changes in CB1 and TRPV1 receptors observed in situ, which was prevented by co-treatment with RU-486 or WIN55,212-2.	Corticosterone	52-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-106
21083631-9	2011	The early rises in plasma corticosterone preceding StAR and P450scc gene transcription suggest that post-transcriptional and post-translational changes in StAR protein mediate the early steroidogenic responses.	Corticosterone	26-40	steroidogenic acute regulatory protein	Rattus norvegicus	155-159
21092068-1	2011	Corticosterone activates two types of intracellular receptors in the rodent brain: the high affinity mineralocorticoid receptor (MR) and lower affinity glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Mus musculus	101-127
21092068-1	2011	Corticosterone activates two types of intracellular receptors in the rodent brain: the high affinity mineralocorticoid receptor (MR) and lower affinity glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Mus musculus	129-131
21092068-1	2011	Corticosterone activates two types of intracellular receptors in the rodent brain: the high affinity mineralocorticoid receptor (MR) and lower affinity glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Mus musculus	152-175
21092068-1	2011	Corticosterone activates two types of intracellular receptors in the rodent brain: the high affinity mineralocorticoid receptor (MR) and lower affinity glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Mus musculus	177-179
21092068-3	2011	For example, in CA1 pyramidal cells, corticosterone slowly changes Ca(2+) currents and glutamate transmission but dentate granule cells appear to be resistant.	Corticosterone	37-51	carbonic anhydrase 1	Mus musculus	16-19
20093322-4	2011	RU486 potentiated the effect of corticosterone on glucocorticoid receptor nuclear translocation and DNA binding, S-P inhibited corticosterone-induced glucocorticoid receptor nuclear translocation, but not glucocorticoid receptor-DNA binding.	Corticosterone	32-46	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	50-73
20093322-4	2011	RU486 potentiated the effect of corticosterone on glucocorticoid receptor nuclear translocation and DNA binding, S-P inhibited corticosterone-induced glucocorticoid receptor nuclear translocation, but not glucocorticoid receptor-DNA binding.	Corticosterone	127-141	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	150-173
20093322-4	2011	RU486 potentiated the effect of corticosterone on glucocorticoid receptor nuclear translocation and DNA binding, S-P inhibited corticosterone-induced glucocorticoid receptor nuclear translocation, but not glucocorticoid receptor-DNA binding.	Corticosterone	127-141	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	150-173
21560335-4	2011	Serum corticosterone (CORT) level was determined by radioimmunoassay kit.	Corticosterone	6-20	cortistatin	Rattus norvegicus	22-26
21304589-4	2011	In adrenalectomized mice, Dkk-1 was induced by corticosterone injection, but not by exposure to stress.	Corticosterone	47-61	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	26-31
21070780-11	2011	CONCLUSIONS: These results support a novel role for corticosterone to modulate CB1 and TRPV1-receptor pathways in L6-S2 DRGs in the chronic WA stressed rat, which contributes to visceral hyperalgesia observed in this model.	Corticosterone	52-66	cannabinoid receptor 1	Rattus norvegicus	79-82
21070780-11	2011	CONCLUSIONS: These results support a novel role for corticosterone to modulate CB1 and TRPV1-receptor pathways in L6-S2 DRGs in the chronic WA stressed rat, which contributes to visceral hyperalgesia observed in this model.	Corticosterone	52-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-92
20946941-9	2011	Unexpectedly, the lack of VP did not alter the effect of CUS on the somatic and behavioural measures, but only prevented CUS-induced corticosterone changes.	Corticosterone	133-147	arginine vasopressin	Rattus norvegicus	26-28
21957575-4	2011	FTS level in old mice increased after administration of thymalin, the rhythm of CD(4+)-cells number in bone marrow and of corticosterone serum content restored.	Corticosterone	122-136	AKT interacting protein	Mus musculus	0-3
21162119-3	2011	Factors that regulate PDK4 mRNA expression include plasma corticosterone, insulin and free fatty acids.	Corticosterone	58-72	pyruvate dehydrogenase kinase 4	Rattus norvegicus	22-26
20962061-9	2011	The OCT/Oct inhibitor corticosterone, at a concentration of 1 muM (IC(50), 1.11 +- 0.20 muM for rOct2-mediated ipratropium transport), inhibited ipratropium by 18.4%, suggesting that rOct2 is involved in renal secretion of ipratropium.	Corticosterone	22-36	plexin A2	Homo sapiens	4-7
20962061-9	2011	The OCT/Oct inhibitor corticosterone, at a concentration of 1 muM (IC(50), 1.11 +- 0.20 muM for rOct2-mediated ipratropium transport), inhibited ipratropium by 18.4%, suggesting that rOct2 is involved in renal secretion of ipratropium.	Corticosterone	22-36	plexin A2	Homo sapiens	8-11
20962061-9	2011	The OCT/Oct inhibitor corticosterone, at a concentration of 1 muM (IC(50), 1.11 +- 0.20 muM for rOct2-mediated ipratropium transport), inhibited ipratropium by 18.4%, suggesting that rOct2 is involved in renal secretion of ipratropium.	Corticosterone	22-36	solute carrier family 22 member 2	Rattus norvegicus	96-101
20962061-9	2011	The OCT/Oct inhibitor corticosterone, at a concentration of 1 muM (IC(50), 1.11 +- 0.20 muM for rOct2-mediated ipratropium transport), inhibited ipratropium by 18.4%, suggesting that rOct2 is involved in renal secretion of ipratropium.	Corticosterone	22-36	solute carrier family 22 member 2	Rattus norvegicus	183-188
21304589-5	2011	Corticosterone also induced Dkk-1 in mouse organotypic hippocampal cultures and primary cultures of hippocampal neurons and, at least in the latter model, the action of corticosterone was reversed by the type-2 glucocorticoid receptor antagonist mifepristone.	Corticosterone	0-14	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	28-33
21304589-5	2011	Corticosterone also induced Dkk-1 in mouse organotypic hippocampal cultures and primary cultures of hippocampal neurons and, at least in the latter model, the action of corticosterone was reversed by the type-2 glucocorticoid receptor antagonist mifepristone.	Corticosterone	169-183	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	28-33
21389639-5	2011	Circulating corticosterone levels in CRH-Tg were markedly elevated at both 6 and 14 weeks old.	Corticosterone	12-26	corticotropin releasing hormone	Mus musculus	37-40
21879473-1	2011	BACKGROUND: 11-beta-hydroxysteroid dehydrogenase type I (11-beta-HSD1) in the white adipose tissue (WAT) of rats catalyses the conversion of 11-dehydrocorticosterone to corticosterone, a more active glucocorticosteroid.	Corticosterone	151-165	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	57-69
20874763-0	2011	The vasopressin V1b receptor modulates plasma corticosterone responses to dehydration-induced stress.	Corticosterone	46-60	arginine vasopressin receptor 1B	Mus musculus	4-28
21407156-0	2011	The influence of cocaine-amphetamine regulated transcript (CART) on pituitary hormones, corticosterone and leptin levels in starved rats.	Corticosterone	88-102	CART prepropeptide	Rattus norvegicus	59-63
21407156-8	2011	RESULTS: Itracerebroventricular CART injection resulted in a significant increase in PRL, GH and corticosterone concentrations in non-starved rats compared with vehicle injected animals.	Corticosterone	97-111	CART prepropeptide	Rattus norvegicus	32-36
21106873-11	2011	Similarly, aldosterone increased vascular cell adhesion molecule 1 expression in mouse aortic endothelial cells, an effect mimicked by corticosterone only in the presence of an 11beta-HSD2 inhibitor.	Corticosterone	135-149	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	177-188
21160171-0	2011	Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice.	Corticosterone	9-23	brain derived neurotrophic factor	Mus musculus	54-86
21160171-0	2011	Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice.	Corticosterone	9-23	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	91-95
21160171-3	2011	Leptin receptor-deficient mice (db/db) show reduced expression of brain-derived neurotropic factor (BDNF) in the hippocampus and increases in circulating corticosterone levels, but the extent to which elevated corticosterone levels mediate deficits in BDNF expression has not been determined.	Corticosterone	154-168	leptin receptor	Mus musculus	0-15
21160171-3	2011	Leptin receptor-deficient mice (db/db) show reduced expression of brain-derived neurotropic factor (BDNF) in the hippocampus and increases in circulating corticosterone levels, but the extent to which elevated corticosterone levels mediate deficits in BDNF expression has not been determined.	Corticosterone	210-224	leptin receptor	Mus musculus	0-15
21160171-5	2011	RESULTS: Lowering corticosterone levels restored BDNF and TrkB expression in the hippocampus of db/db mice.	Corticosterone	18-32	brain derived neurotrophic factor	Mus musculus	49-53
21160171-5	2011	RESULTS: Lowering corticosterone levels restored BDNF and TrkB expression in the hippocampus of db/db mice.	Corticosterone	18-32	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	58-62
21389736-9	2011	A model is proposed linking IL-6 to endocrine-derived factors which allows modification of active corticosterone into inert 11-dehydrocorticosterone at the site of granuloma formation to limit excessive parenchymal damage.	Corticosterone	98-112	interleukin 6	Mus musculus	28-32
22024815-7	2011	By contrast, antagonist treatment to block MR (RU-28318) or GR (Mifepristone, RU-486) prevented motor impairments caused by acute restraint stress or corticosterone treatment.	Corticosterone	150-164	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	43-45
22024815-7	2011	By contrast, antagonist treatment to block MR (RU-28318) or GR (Mifepristone, RU-486) prevented motor impairments caused by acute restraint stress or corticosterone treatment.	Corticosterone	150-164	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	60-62
20927049-9	2011	HCR rats, however, exhibited a greater corticosterone response following the light/dark box.	Corticosterone	39-53	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	0-3
22145038-5	2011	Circulating ACTH and corticosterone levels are elevated in juvenile and aged Prop1 mutants, indicating activation of the pituitary-adrenal axis.	Corticosterone	21-35	paired like homeodomain factor 1	Mus musculus	77-82
22145038-6	2011	Despite this, young adult Prop1 deficient mice are capable of responding to restraint stress with further elevation of ACTH and corticosterone.	Corticosterone	128-142	paired like homeodomain factor 1	Mus musculus	26-31
22039440-0	2011	Cysteamine attenuates the decreases in TrkB protein levels and the anxiety/depression-like behaviors in mice induced by corticosterone treatment.	Corticosterone	120-134	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	39-43
22039440-5	2011	RESULTS: Cysteamine administration (150 mg/kg/day, through drinking water) for 21 days significantly ameliorated chronic corticosterone-induced decreases in TrkB protein levels in frontal cortex and hippocampus.	Corticosterone	121-135	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	157-161
21935393-8	2011	Co-labelling with BrdU (thymidine analog) /doublecortin (immature neuronal marker) showed that running increased neuronal differentiation in vehicle- and CORT-treated rats.	Corticosterone	154-158	doublecortin	Rattus norvegicus	43-55
21272629-6	2011	This enigmatic observation led to the discovery that protection from acoustic trauma in older beta2(-/-) mice is mainly mediated by an age-related increase of corticosterone, not disruption of efferent cholinergic transmission.	Corticosterone	159-173	hemoglobin, beta adult minor chain	Mus musculus	94-99
22069501-1	2011	Stress exerts a profound impact on learning and memory, in part, through the actions of adrenal corticosterone (CORT) on synaptic plasticity, a cellular model of learning and memory.	Corticosterone	96-110	cortistatin	Rattus norvegicus	112-116
21647420-0	2011	Long-term continuous corticosterone treatment decreases VEGF receptor-2 expression in frontal cortex.	Corticosterone	21-35	vascular endothelial growth factor A	Homo sapiens	56-60
21647420-5	2011	RESULTS: We found that long-term continuous exposure to corticosterone (CORT, a natural glucocorticoid) reduced Flk1 protein levels both in vitro and in vivo.	Corticosterone	56-70	cortistatin	Homo sapiens	72-76
21647420-5	2011	RESULTS: We found that long-term continuous exposure to corticosterone (CORT, a natural glucocorticoid) reduced Flk1 protein levels both in vitro and in vivo.	Corticosterone	56-70	kinase insert domain receptor	Homo sapiens	112-116
21655274-0	2011	Plasma corticosterone activates SGK1 and induces morphological changes in oligodendrocytes in corpus callosum.	Corticosterone	7-21	serum/glucocorticoid regulated kinase 1	Mus musculus	32-36
20573588-1	2010	Corticosterone (CORT) localized to the amygdala induces anxiety-like behavior coupled with increased behavioral responses to visceral and somatic stimuli.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
20599566-4	2010	Thus, the aim of this study was to investigate the effects of a postnatal exposure to synthetic predator odor (TMT) in mice pups on later adult fear-related behaviors and corticosterone levels in response to this specific stimulus.	Corticosterone	171-185	tryptase gamma 1	Mus musculus	111-114
21157967-5	2010	In adrenocortical cells, SR-BI mediates the selective uptake of HDL-cholesteryl esters, which is efficiently coupled to the synthesis of glucocorticoids (i.e. corticosterone).	Corticosterone	159-173	scavenger receptor class B, member 1	Mus musculus	25-30
21162750-8	2010	Results of experiments carried out in BALB/c mice demonstrated that serum levels of TNF-alpha after LPS treatment were also reduced (20--48%; P &lt; 0.05) by tocotrienols with doses of 1 and 10 mug/kg, and a corresponding rise in serum levels of corticosterone (19--41%; P &lt; 0.05) and adrenocorticotropic hormone (81--145%; P &lt; 0.02) was observed at higher concentrations (40 muM).	Corticosterone	246-260	tumor necrosis factor	Mus musculus	84-93
20654639-5	2010	Exposure of these oocytes to corticosterone (0.01-1 muM) for 72 h decreased EAAC1 activity in a dose-dependent fashion, and this inhibition was incubation time-dependent.	Corticosterone	29-43	solute carrier family 1 member 1	Rattus norvegicus	76-81
20654639-6	2010	Corticosterone (0.01 muM for 72 h) significantly decreased the V(max), but not the K(m), of EAAC1 for glutamate.	Corticosterone	0-14	solute carrier family 1 member 1	Rattus norvegicus	92-97
20654639-10	2010	Phorbol-12-myristate-13-acetate (PMA), a PKC activator, inhibited corticosterone-induced reduction in EAAC1 activity.	Corticosterone	66-80	solute carrier family 1 member 1	Rattus norvegicus	102-107
20654639-12	2010	The above results suggest that corticosterone exposure reduces EAAC1 activity and this effect is PKC- and PI3K-dependent.	Corticosterone	31-45	solute carrier family 1 member 1	Rattus norvegicus	63-68
19909806-1	2010	Cortisol and aldosterone have the same in vitro affinity for the mineralocorticoid receptor (MR), although in vivo only aldosterone acts as a physiologic agonist of the MR, despite circulating levels of cortisol in humans and corticosterone in rodents being three orders of magnitude higher than aldosterone levels.	Corticosterone	226-240	nuclear receptor subfamily 3 group C member 2	Homo sapiens	65-91
20798244-6	2010	The effects of testosterone in castrated mice on thymocyte homeostasis and GC release were strongly reduced in mice pretreated with the CYP11B1 enzyme inhibitor metyrapone, acting on the last step in the corticosterone synthesis.	Corticosterone	204-218	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	136-143
20850442-5	2010	We asked whether dermal patches containing corticosterone (CORT, the main GC in amphibians) would elevate plasma CORT in terrestrial salamanders and frogs.	Corticosterone	43-57	cortistatin	Homo sapiens	59-63
21478090-2	2010	Since the correlation among vasopressin (VP), adrenocorticotropic hormone (ACTH) and corticosterone (CORT) responses to various stressors have been long recognized, the aim of this study was to reveal the aforementioned hormones production and morphology of the pituitary gland after exposure to acute heat.	Corticosterone	85-99	cortistatin	Rattus norvegicus	101-105
20850442-5	2010	We asked whether dermal patches containing corticosterone (CORT, the main GC in amphibians) would elevate plasma CORT in terrestrial salamanders and frogs.	Corticosterone	43-57	cortistatin	Homo sapiens	113-117
20923496-9	2010	However, serum corticosterone levels were significantly correlated with 11beta-HSD1 reductase activity when all groups were analyzed together (P &lt; 0.05).	Corticosterone	15-29	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	72-83
21062430-0	2010	Differential cellular FGF-2 upregulation in the rat facial nucleus following axotomy, functional electrical stimulation and corticosterone: a possible therapeutic target to Bell"s palsy.	Corticosterone	124-138	fibroblast growth factor 2	Rattus norvegicus	22-27
20837582-9	2010	These results suggest that NP acts directly on rat ZFR cells to stimulate corticosterone release and that the stimulation mechanism of NP mediates through post-cAMP corticosterone manufacture enzymes, i.e., P450scc and 11beta-hydroxylase.	Corticosterone	165-179	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	207-214
20871212-3	2010	When human estrogen receptor (hERalpha) and SXR were exogenously expressed, treatment with either rifampicin or corticosterone promoted significantly the SXR-mediated transactivation of LXRE reporter gene in HepG2.	Corticosterone	112-126	estrogen receptor 1	Homo sapiens	11-39
20871212-3	2010	When human estrogen receptor (hERalpha) and SXR were exogenously expressed, treatment with either rifampicin or corticosterone promoted significantly the SXR-mediated transactivation of LXRE reporter gene in HepG2.	Corticosterone	112-126	nuclear receptor subfamily 1 group I member 2	Homo sapiens	44-47
20871212-3	2010	When human estrogen receptor (hERalpha) and SXR were exogenously expressed, treatment with either rifampicin or corticosterone promoted significantly the SXR-mediated transactivation of LXRE reporter gene in HepG2.	Corticosterone	112-126	nuclear receptor subfamily 1 group I member 2	Homo sapiens	154-157
21068324-0	2010	Repeated swim impairs serotonin clearance via a corticosterone-sensitive mechanism: organic cation transporter 3, the smoking gun.	Corticosterone	48-62	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	84-112
21068324-7	2010	Moreover, corticosterone, which is released upon HPA axis activation, blocks 5-HT uptake by OCT3.	Corticosterone	10-24	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	92-96
21068324-8	2010	Repeated swim produced a persistent elevation in plasma corticosterone, and, consistent with prolonged blockade by corticosterone, we found that OCT3 expression and function were reduced in these mice.	Corticosterone	115-129	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	145-149
21068324-11	2010	Together, these results show that reduced 5-HT clearance following HPA axis activation is likely mediated, at least in part, by the corticosterone-sensitive OCT3, and that drugs developed to selectively target OCT3 (unlike corticosterone) may be candidates for the development of novel antidepressant medications.	Corticosterone	132-146	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	157-161
21062430-10	2010	Image analysis reveled that a seven days functional electrical stimulation or corticosterone led to elevations of FGF-2 in the cytoplasm of neurons and in the nucleus of reactive astrocytes, respectively, without astrocytic reaction.	Corticosterone	78-92	fibroblast growth factor 2	Rattus norvegicus	114-119
20659135-14	2010	These data, together with a previous study showing both ACTH and corticosterone are increased in GRKO mice, show that the GR is required for the development of ACTH-induced hypertension in mice.	Corticosterone	65-79	pro-opiomelanocortin-alpha	Mus musculus	160-164
20966530-2	2010	Intracerebroventricular (icv) administration of nesfatin-1 produces fear-related behaviors and potentiates stressor-induced increases in plasma adrenocorticotropic hormone (ACTH) and corticosterone levels in rats.	Corticosterone	183-197	nucleobindin 2	Rattus norvegicus	48-58
20966530-8	2010	Icv nesfatin-1 increased plasma ACTH and corticosterone levels.	Corticosterone	41-55	nucleobindin 2	Rattus norvegicus	4-14
20881239-3	2010	Previously, we demonstrated that MC2R(-/-) mice had undetectable levels of corticosterone despite high ACTH levels.	Corticosterone	75-89	melanocortin 2 receptor	Mus musculus	33-37
20843996-0	2010	Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice.	Corticosterone	0-14	pro-opiomelanocortin-alpha	Mus musculus	56-60
20843996-0	2010	Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice.	Corticosterone	0-14	neuropeptide Y	Mus musculus	65-68
20853513-9	2010	These effects of TIP39 on pCREB-ir, corticosterone, and prolactin were abolished by coinfusion of the ionotropic glutamate receptor antagonists 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and DL-2-amino-5-phosphonopentanoic acid (AP-5; 30 pmol each) and were absent in PTH2R knockout mice.	Corticosterone	36-50	parathyroid hormone 2	Mus musculus	17-22
20843996-0	2010	Corticosterone regulates synaptic input organization of POMC and NPY/AgRP neurons in adult mice.	Corticosterone	0-14	agouti related neuropeptide	Mus musculus	69-73
20843996-4	2010	Corticosterone replacement in ADX mice to levels similar to sham-operated animals restored the number of synapses onto POMC and NPY/AgRP neurons to that seen in sham-operated controls.	Corticosterone	0-14	pro-opiomelanocortin-alpha	Mus musculus	119-123
20843996-4	2010	Corticosterone replacement in ADX mice to levels similar to sham-operated animals restored the number of synapses onto POMC and NPY/AgRP neurons to that seen in sham-operated controls.	Corticosterone	0-14	neuropeptide Y	Mus musculus	128-131
20843996-4	2010	Corticosterone replacement in ADX mice to levels similar to sham-operated animals restored the number of synapses onto POMC and NPY/AgRP neurons to that seen in sham-operated controls.	Corticosterone	0-14	agouti related neuropeptide	Mus musculus	132-136
20688070-2	2010	Prolonged elevated levels of glucocorticoids are associated with depression and we developed an animal model of postpartum depression/stress based on high levels of corticosterone (CORT) during the postpartum.	Corticosterone	165-179	cortistatin	Homo sapiens	181-185
21103031-2	2010	When rats were subcutaneously injected with corticosterone, lipid hydroperoxides and protein carbonyls increased markedly in the hippocampus in association with a decrease in activity of antioxidative enzymes, such as superoxide dismutase, catalase and glutathione peroxidase.	Corticosterone	44-58	catalase	Rattus norvegicus	240-248
20853513-10	2010	Basal plasma corticosterone was slightly decreased in TIP39 knockout mice just before onset of their active phase.	Corticosterone	13-27	parathyroid hormone 2	Mus musculus	54-59
20735798-3	2010	In the present study, three mouse lines selectively bred for high (HR), intermediate (IR) or low (LR) stress reactivity were used to elucidate the temporal dynamics of intrahippocampal corticosterone (CORT) in response to a standardised stressor.	Corticosterone	185-199	cortistatin	Mus musculus	201-205
21273654-2	2010	Brain IL-1 is an important mediator in stress-induced stimulation of the limbic-hypothalamic-pituitary-adrenal axis and secretion of ACTH and corticosterone.	Corticosterone	142-156	interleukin 1 alpha	Homo sapiens	6-10
21829438-7	2011	In adrenalectomized rats, net hippocampus-synthesized corticosterone (CORT) and DOC were determined to 6.9 and 5.8 nM, respectively.	Corticosterone	54-68	cortistatin	Rattus norvegicus	70-74
20666662-9	2010	Pre-treatment of slices with 100-nM corticosterone (CORT) vs. dimethylsulphoxide (DMSO) for 20 min significantly abolished the nociceptin-induced inhibition of firing rate (P &lt; 0.001) when tested 2 h later.	Corticosterone	36-50	prepronociceptin	Rattus norvegicus	127-137
20666642-1	2010	Methamphetamine (MA) induces multiple effects in rats including alterations to corticosterone (CORT) and adrenocorticotropic hormone (ACTH).	Corticosterone	79-93	cortistatin	Rattus norvegicus	95-99
20682296-9	2010	Following restraint, HCR animals exhibited more anxiotypic behavior than LCR animals on the EPM, and exhibited an increase in plasma corticosterone following EPM and restraint that was not observed in LCR animals.	Corticosterone	133-147	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	21-24
19957051-6	2010	In the hippocampal neurons, corticosterone decreased expression of ferritin and increased expression of transferrin receptor1 (TfR1), iron regulatory protein1 (IRP1), and divalent metal transporter 1.	Corticosterone	28-42	transferrin receptor	Homo sapiens	104-125
19957051-6	2010	In the hippocampal neurons, corticosterone decreased expression of ferritin and increased expression of transferrin receptor1 (TfR1), iron regulatory protein1 (IRP1), and divalent metal transporter 1.	Corticosterone	28-42	transferrin receptor	Homo sapiens	127-131
19957051-6	2010	In the hippocampal neurons, corticosterone decreased expression of ferritin and increased expression of transferrin receptor1 (TfR1), iron regulatory protein1 (IRP1), and divalent metal transporter 1.	Corticosterone	28-42	aconitase 1	Homo sapiens	134-158
19957051-6	2010	In the hippocampal neurons, corticosterone decreased expression of ferritin and increased expression of transferrin receptor1 (TfR1), iron regulatory protein1 (IRP1), and divalent metal transporter 1.	Corticosterone	28-42	aconitase 1	Homo sapiens	160-164
19957051-7	2010	Corticosterone-induced elevation of IRP1 expression can cause increase of TfR1 and decrease of ferritin expression, which further leads to iron accumulation in hippocampal neurons and subsequently increases the oxidative damage of the neurons; it is indicated that corticosterone might be an important reason for iron deposition-caused neurodegenerative diseases.	Corticosterone	0-14	aconitase 1	Homo sapiens	36-40
19957051-7	2010	Corticosterone-induced elevation of IRP1 expression can cause increase of TfR1 and decrease of ferritin expression, which further leads to iron accumulation in hippocampal neurons and subsequently increases the oxidative damage of the neurons; it is indicated that corticosterone might be an important reason for iron deposition-caused neurodegenerative diseases.	Corticosterone	0-14	transferrin receptor	Homo sapiens	74-78
19957051-7	2010	Corticosterone-induced elevation of IRP1 expression can cause increase of TfR1 and decrease of ferritin expression, which further leads to iron accumulation in hippocampal neurons and subsequently increases the oxidative damage of the neurons; it is indicated that corticosterone might be an important reason for iron deposition-caused neurodegenerative diseases.	Corticosterone	265-279	aconitase 1	Homo sapiens	36-40
20600818-6	2010	We measured spontaneous and corticotropin-releasing factor-mediated release of plasma corticosterone.	Corticosterone	86-100	corticotropin releasing hormone	Rattus norvegicus	28-58
20637837-10	2010	Destabilization in proportions between T CD4+ and T CD8+ was manifested as an elevated CD4/CD8 ratio that occurred despite increased plasma corticosterone and the lymphocytopenia.	Corticosterone	140-154	Cd4 molecule	Rattus norvegicus	41-44
20422314-0	2010	Exogenous corticosterone induces the expression of the clock protein, PERIOD2, in the oval nucleus of the bed nucleus of the stria terminalis and the central nucleus of the amygdala of adrenalectomized and intact rats.	Corticosterone	10-24	clock circadian regulator	Rattus norvegicus	55-60
20422314-0	2010	Exogenous corticosterone induces the expression of the clock protein, PERIOD2, in the oval nucleus of the bed nucleus of the stria terminalis and the central nucleus of the amygdala of adrenalectomized and intact rats.	Corticosterone	10-24	period circadian regulator 2	Rattus norvegicus	70-77
20422314-1	2010	The cyclical expression of the clock protein PERIOD2 (PER2) in select regions of the limbic forebrain is contingent upon the rhythmic secretion of the adrenal glucocorticoid, corticosterone.	Corticosterone	175-189	clock circadian regulator	Rattus norvegicus	31-36
20422314-1	2010	The cyclical expression of the clock protein PERIOD2 (PER2) in select regions of the limbic forebrain is contingent upon the rhythmic secretion of the adrenal glucocorticoid, corticosterone.	Corticosterone	175-189	period circadian regulator 2	Rattus norvegicus	45-52
20422314-1	2010	The cyclical expression of the clock protein PERIOD2 (PER2) in select regions of the limbic forebrain is contingent upon the rhythmic secretion of the adrenal glucocorticoid, corticosterone.	Corticosterone	175-189	period circadian regulator 2	Rattus norvegicus	54-58
20422314-3	2010	Here, we investigated the effects of serial or acute systemic injections of corticosterone on the expression of PER2 in the BNSTov and CEA of both adrenalectomized (ADX) and intact rats.	Corticosterone	76-90	period circadian regulator 2	Rattus norvegicus	112-116
20422314-5	2010	We found that daily morning injections of corticosterone induced PER2 expression in the BNSTov and CEA of ADX rats, with levels peaking 1 h after injection.	Corticosterone	42-56	period circadian regulator 2	Rattus norvegicus	65-69
20422314-5	2010	We found that daily morning injections of corticosterone induced PER2 expression in the BNSTov and CEA of ADX rats, with levels peaking 1 h after injection.	Corticosterone	42-56	carcinoembryonic antigen gene family 4	Rattus norvegicus	99-102
20422314-7	2010	Our findings suggest that despite the potential masking effect of signals from the light-entrained master clock, daytime chronic and acute corticosterone administration can alter the rhythmic expression of PER2 in the BNSTov and CEA, and that the response is region-specific and dependent on the duration of treatment.	Corticosterone	139-153	period circadian regulator 2	Rattus norvegicus	206-210
20422314-7	2010	Our findings suggest that despite the potential masking effect of signals from the light-entrained master clock, daytime chronic and acute corticosterone administration can alter the rhythmic expression of PER2 in the BNSTov and CEA, and that the response is region-specific and dependent on the duration of treatment.	Corticosterone	139-153	carcinoembryonic antigen gene family 4	Rattus norvegicus	229-232
20678573-2	2010	We found that the corticosterone-inactivating enzyme 11beta-hydroxysteroid dehydrogenase type 2 (HSD2) was up-regulated 7 days after lesion in freeze-injured nerve.	Corticosterone	18-32	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	53-95
20678573-2	2010	We found that the corticosterone-inactivating enzyme 11beta-hydroxysteroid dehydrogenase type 2 (HSD2) was up-regulated 7 days after lesion in freeze-injured nerve.	Corticosterone	18-32	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	97-101
20678573-3	2010	The maintenance of a low intracellular level of corticosterone by HSD2 activity in the regenerating nerve is concordant with the improvement of nervous function in injured animals (as measured by walking ability) after treatment by the GR antagonist mifepristone and with the reduction in GR participation in accumulation of the mRNA for numerous endogenous genes (from the renin-angiotensin system and other classical mineralocorticoid-responsive genes), in the same animals.	Corticosterone	48-62	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	66-70
20435076-6	2010	Intracerebro-ventricular administration of nesfatin-1 elevated both plasma adrenocorticotropin and corticosterone levels, while in vitro stimulation of the hypophysis was ineffective.	Corticosterone	99-113	nucleobindin 2	Rattus norvegicus	43-53
20666662-9	2010	Pre-treatment of slices with 100-nM corticosterone (CORT) vs. dimethylsulphoxide (DMSO) for 20 min significantly abolished the nociceptin-induced inhibition of firing rate (P &lt; 0.001) when tested 2 h later.	Corticosterone	52-56	prepronociceptin	Rattus norvegicus	127-137
20600666-0	2010	Chronic corticosterone administration down-regulates metabotropic glutamate receptor 5 protein expression in the rat hippocampus.	Corticosterone	8-22	glutamate metabotropic receptor 5	Rattus norvegicus	53-86
20600666-3	2010	In the present study, we examined the effect of chronic corticosterone (CORT) administration on the expression of mGluR5 protein and mRNA in the rat frontal cortex and hippocampus.	Corticosterone	56-70	glutamate receptor, ionotropic, kainate 1	Mus musculus	114-120
20600666-3	2010	In the present study, we examined the effect of chronic corticosterone (CORT) administration on the expression of mGluR5 protein and mRNA in the rat frontal cortex and hippocampus.	Corticosterone	72-76	glutamate receptor, ionotropic, kainate 1	Mus musculus	114-120
20843768-12	2010	Corticosterone levels of CORT rats were significantly higher after the stress period than before stress application.	Corticosterone	0-14	cortistatin	Rattus norvegicus	25-29
20939989-6	2010	The level of serum corticosterone (CORT) was detected by enzyme-linked immunosorbent assay.	Corticosterone	19-33	cortistatin	Rattus norvegicus	35-39
20420936-9	2010	The current data indicate that the 1alpha,25-dihydroxyvitamin D(3)-mediated decrease in corticosterone and androgen production is due to suppression of the 21-hydroxylase activity by CYP21A2 and the 17,20-lyase activity by CYP17A1, respectively.	Corticosterone	88-102	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	183-190
20420936-9	2010	The current data indicate that the 1alpha,25-dihydroxyvitamin D(3)-mediated decrease in corticosterone and androgen production is due to suppression of the 21-hydroxylase activity by CYP21A2 and the 17,20-lyase activity by CYP17A1, respectively.	Corticosterone	88-102	cytochrome P450 family 17 subfamily A member 1	Homo sapiens	223-230
20518015-2	2010	We created an animal model of postpartum depression/stress based on giving high levels of corticosterone (CORT) to the rat dam, which resulted in behavioral and neural changes in the offspring.	Corticosterone	90-104	cortistatin	Rattus norvegicus	106-110
20668026-0	2010	Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice.	Corticosterone	8-22	FK506 binding protein 5	Mus musculus	104-109
20668026-2	2010	We tested the hypothesis that expression changes would be induced in Fkbp5 and other HPA axis genes by chronic exposure to corticosterone and that these changes would occur through the epigenetic mechanism of loss or gain of DNA methylation (DNAm).	Corticosterone	123-137	FK506 binding protein 5	Mus musculus	69-74
20668026-3	2010	We administered corticosterone (CORT) to C57BL/6J mice via their drinking water for 4 wk and tested for behavioral and physiological changes and changes in gene expression levels using RNA extracted from hippocampus, hypothalamus, and blood for the following HPA genes: Fkbp5, Nr3c1, Hsp90, Crh, and Crhr1.	Corticosterone	16-30	cortistatin	Mus musculus	32-36
20626564-6	2010	The expression level of brain-specific transcription factor neuronal PAS domain protein 4 (Npas4) mRNA in the hippocampus was down-regulated by the restraint stress or by acute corticosterone treatment.	Corticosterone	177-191	neuronal PAS domain protein 4	Mus musculus	60-89
20626564-6	2010	The expression level of brain-specific transcription factor neuronal PAS domain protein 4 (Npas4) mRNA in the hippocampus was down-regulated by the restraint stress or by acute corticosterone treatment.	Corticosterone	177-191	neuronal PAS domain protein 4	Mus musculus	91-96
20626564-9	2010	Corticosterone-induced down-regulation of Npas4 expression may play a role in stress-induced impairment of hippocampal function.	Corticosterone	0-14	neuronal PAS domain protein 4	Mus musculus	42-47
20661756-14	2010	A significant correlation was detected between cerebral AChE and corticosterone concentrations as well as between AChE and psychometric parameters.	Corticosterone	65-79	acetylcholinesterase	Rattus norvegicus	56-60
20595541-7	2010	In addition, blood glucose levels decreased and corticosterone levels increased to a greater extent in MSTN-null mice after 2 days of FD, but surprisingly muscle MuRF-1 and atrogin-1 mRNA levels were not affected by the lack of MSTN during FD.	Corticosterone	48-62	myostatin	Mus musculus	103-107
20586888-2	2010	Corticosterone inhibits pineal NFKB leading to an enhancement of melatonin production, while tumor necrosis factor (TNF) leads to inhibition of Aa-nat transcription and the production of N-acetylserotonin in cultured glands.	Corticosterone	0-14	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	31-35
20470889-6	2010	These findings moderate the prevailing view and indicate that brain cyclooxygenase-2-dependent prostaglandin production is important to activation of the median preoptic and arcuate hypothalamus, but not necessarily involved in fever, rises in plasma corticosterone and anorexia after peripheral interleukin-1beta administration.	Corticosterone	251-265	prostaglandin-endoperoxide synthase 2	Homo sapiens	68-84
20600433-6	2010	Globular domain of adiponectin at 10(-9) M stimulated corticosterone output and BrdU incorporation by cultured rat adrenocortical cells.	Corticosterone	54-68	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	19-30
20171785-0	2010	Abnormal response to stress and impaired NPS-induced hyperlocomotion, anxiolytic effect and corticosterone increase in mice lacking NPSR1.	Corticosterone	92-106	neuropeptide S receptor 1	Mus musculus	132-137
21141500-5	2010	CONCLUSION: The data indicated that the principal mechanism of prophylactic neuroprotective effect of PF on corticosterone-induced neurons damages maybe due to PF can raise the expression of apoptosis-related genes Bel-2, Bax, Caspase-3 mRNA, and also ascribe to PF can raise the expression of neurotrophic factor.	Corticosterone	108-122	BCL2 associated X, apoptosis regulator	Rattus norvegicus	222-225
21141500-5	2010	CONCLUSION: The data indicated that the principal mechanism of prophylactic neuroprotective effect of PF on corticosterone-induced neurons damages maybe due to PF can raise the expression of apoptosis-related genes Bel-2, Bax, Caspase-3 mRNA, and also ascribe to PF can raise the expression of neurotrophic factor.	Corticosterone	108-122	caspase 3	Rattus norvegicus	227-236
21141500-5	2010	CONCLUSION: The data indicated that the principal mechanism of prophylactic neuroprotective effect of PF on corticosterone-induced neurons damages maybe due to PF can raise the expression of apoptosis-related genes Bel-2, Bax, Caspase-3 mRNA, and also ascribe to PF can raise the expression of neurotrophic factor.	Corticosterone	108-122	neurotrophin 3	Rattus norvegicus	294-313
20838478-6	2010	Plasma levels of corticosterone and interleukin (IL)-6 concomitantly increased after aggressive encounters and varied with dominance status and with the low versus high corticosterone response.	Corticosterone	169-183	interleukin 6	Mus musculus	36-54
20663957-5	2010	Importantly, the long-lasting change in state of amygdala neurons greatly affects the responsiveness to subsequent surges of corticosterone, revealing a quick suppression of glutamatergic transmission, which requires the glucocorticoid receptor.	Corticosterone	125-139	nuclear receptor subfamily 3 group C member 1	Homo sapiens	221-244
20399847-4	2010	The rise in plasma corticosterone levels after the maze test was greater in p50 knockout than in wildtype mice.	Corticosterone	19-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	76-79
20399847-6	2010	Adrenalectomy with corticosterone replacement eliminated the differences between p50 knockout and wildtype mice in the water maze.	Corticosterone	19-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-84
20385375-6	2010	We found reduced expression of mineralocorticoid receptor (MR) transcripts in the hippocampus and reduction in the corticosterone-induced, MR-mediated nongenomic modulatory effects on CA1 synaptic transmission.	Corticosterone	115-129	nuclear receptor subfamily 3, group C, member 2	Mus musculus	139-141
20544861-9	2010	Moreover, 11 beta HSD-1 catalyzed the metabolic conversion of 11-dehydro-corticosterone into corticosterone (CORT), which potently reduced cytokine production in activated microglia.	Corticosterone	73-87	RNA, U1 small nuclear 1	Homo sapiens	18-23
20544861-9	2010	Moreover, 11 beta HSD-1 catalyzed the metabolic conversion of 11-dehydro-corticosterone into corticosterone (CORT), which potently reduced cytokine production in activated microglia.	Corticosterone	109-113	RNA, U1 small nuclear 1	Homo sapiens	18-23
20403087-11	2010	High-dose corticosterone administration together with norepinephrine caused release of plasma oxytocin and hippocampal oxytocin receptor.	Corticosterone	10-24	oxytocin receptor	Rattus norvegicus	119-136
20385375-6	2010	We found reduced expression of mineralocorticoid receptor (MR) transcripts in the hippocampus and reduction in the corticosterone-induced, MR-mediated nongenomic modulatory effects on CA1 synaptic transmission.	Corticosterone	115-129	carbonic anhydrase 1	Mus musculus	184-187
20385375-7	2010	Importantly, the impaired long-term potentiation in Lsamp(-/-) mice can be rescued by stress-like levels of corticosterone in a MR-dependent manner.	Corticosterone	108-122	limbic system-associated membrane protein	Mus musculus	52-57
20385375-7	2010	Importantly, the impaired long-term potentiation in Lsamp(-/-) mice can be rescued by stress-like levels of corticosterone in a MR-dependent manner.	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 2	Mus musculus	128-130
21032898-5	2010	In DD micetere was more then the 3-fold decrease of blood content of corticosterone, which is involved in PPAR and RXR regulation.	Corticosterone	69-83	peroxisome proliferator activated receptor alpha	Mus musculus	106-110
20226838-6	2010	This study suggests that arthritis upregulates synovial 11HSD1, this upregulation is controlled by TNF-alpha and IL-1beta and that the increased supply of local corticosterone might contribute to feedback regulation of inflammation.	Corticosterone	161-175	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	56-62
20363852-7	2010	Male and female Adcy7(huTG) mice displayed higher plasma adrenocorticotropin and corticosterone levels than WT and/or Adcy7(+/-) mice after ethanol injection.	Corticosterone	81-95	adenylate cyclase 7	Mus musculus	16-21
20189567-3	2010	METHODS AND RESULTS: PON1 deficiency was associated with reduced serum CS concentration.	Corticosterone	71-73	paraoxonase 1	Mus musculus	21-25
20189567-6	2010	Addition of purified PON1 to HDL from PON1KO mice increased HDL binding and CS synthesis.	Corticosterone	76-78	paraoxonase 1	Mus musculus	21-25
20189567-9	2010	CONCLUSION: PON1 regulates adrenal CS biosynthesis at two levels: (a) via an accessory role in HDL binding properties, and (b) a supportive role in SR-BI expression and CE supply to the cells.	Corticosterone	35-37	paraoxonase 1	Mus musculus	12-16
20424233-9	2010	Although physiologic leptin replacement lowered blood glucose levels only slightly, it fully normalized elevated plasma glucagon and corticosterone levels and reversed the increased hepatic expression of gluconeogenic enzymes characteristic of rats with uDM.	Corticosterone	133-147	leptin	Rattus norvegicus	21-27
20463057-4	2010	SR-BI mRNA levels were increased in adrenals from corticosterone-insufficient Crh(-/-) mice, whereas corticosterone replacement by oral administration inhibited SR-BI gene expression in these mice.	Corticosterone	50-64	scavenger receptor class B, member 1	Mus musculus	0-5
20463057-4	2010	SR-BI mRNA levels were increased in adrenals from corticosterone-insufficient Crh(-/-) mice, whereas corticosterone replacement by oral administration inhibited SR-BI gene expression in these mice.	Corticosterone	101-115	scavenger receptor class B, member 1	Mus musculus	161-166
20463057-5	2010	SR-BI mRNA levels were increased in adrenals from wild-type mice treated with metyrapone, a drug that blocks corticosterone synthesis.	Corticosterone	109-123	scavenger receptor class B, member 1	Mus musculus	0-5
20212497-3	2010	We hypothesized that consumption of an HF diet activates HPA axis by increasing norepinephrine (NE) in the paraventricular nucleus (PVN) of the hypothalamus, leading to elevation in corticotrophin-releasing hormone (CRH) concentration in the median eminence (ME) resulting in elevated serum corticosterone (CORT).	Corticosterone	291-305	corticotropin releasing hormone	Rattus norvegicus	182-214
20806395-7	2010	In caput, corpus, and cauda fractions, administration of corticosterone or TCDD increased the levels of lipid peroxidation and hydrogen peroxide and decreased the activities of superoxide dismutase and catalase significantly.	Corticosterone	57-71	catalase	Rattus norvegicus	202-210
20363879-5	2010	GLP-1 increases circulating corticosterone levels in a time-dependent manner, both in conscious and anaesthetized rats, and it has also increased aldosterone levels.	Corticosterone	28-42	glucagon	Rattus norvegicus	0-5
20196138-1	2010	In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle.	Corticosterone	112-126	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	72-98
20196138-1	2010	In the hippocampus, glucocorticoids bind to two types of receptors: the mineralocorticoid receptor, which binds corticosterone with high affinity and is tonically occupied; and the glucocorticoid receptor, which is occupied during stress and at certain phases in the circadian cycle.	Corticosterone	112-126	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	181-204
20483644-0	2010	Angiotensin II-induced reduction in body mass is Ang II receptor mediated in association with elevated corticosterone.	Corticosterone	103-117	angiotensinogen	Rattus norvegicus	0-14
20483644-0	2010	Angiotensin II-induced reduction in body mass is Ang II receptor mediated in association with elevated corticosterone.	Corticosterone	103-117	angiotensinogen	Rattus norvegicus	49-55
20483644-6	2010	Ang II increased plasma corticosterone (B) 3-fold (173+/-28 vs 555+/-42 ng/mL) and ARB treatment prevented the response (150+/-47 ng/mL).	Corticosterone	24-38	angiotensinogen	Rattus norvegicus	0-6
20577031-6	2010	Ghrelin-treated rats had elevated (p&lt;0.05) blood concentrations of ACTH, aldosterone and corticosterone (68%, 32% and 67%, respectively).	Corticosterone	92-106	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
20340066-3	2010	We have shown that neonatal hyperleptinemia on lactation programs for leptin resistance, hyperthyroidism, and higher corticosterone and catecholamines levels with cardiovascular consequences.	Corticosterone	117-131	leptin	Rattus norvegicus	33-39
20348154-5	2010	Both EB and PPT increased corticosterone levels about two- to threefold, but prevented any further rise with either single or repeated IMO, indicating an ERalpha (ESR1)-, but not ERbeta (ESR2)-, mediated mechanism.	Corticosterone	26-40	tachykinin, precursor 1	Rattus norvegicus	12-15
20298457-7	2010	In the present study, we compared blood glucose and plasma glucocorticoid concentrations in PrRP-KO mice, and found that PrRP-KO mice showed higher concentrations of blood glucose and corticosterone compared to wild-type mice after restraint stress.	Corticosterone	184-198	prolactin releasing hormone	Mus musculus	121-125
20232358-7	2010	In addition, CCS-supplemented groups had significantly lower jun D and higher fra-2 than adx groups and sham groups.	Corticosterone	13-16	jun D proto-oncogene	Mus musculus	61-66
20232358-7	2010	In addition, CCS-supplemented groups had significantly lower jun D and higher fra-2 than adx groups and sham groups.	Corticosterone	13-16	fos-like antigen 2	Mus musculus	78-83
20338209-8	2010	Incubation of a decapsulated rat testis with either GSKI or corticosterone accelerated release of TRH, and TRH-like peptides.	Corticosterone	60-74	thyrotropin releasing hormone	Rattus norvegicus	98-101
20338209-8	2010	Incubation of a decapsulated rat testis with either GSKI or corticosterone accelerated release of TRH, and TRH-like peptides.	Corticosterone	60-74	thyrotropin releasing hormone	Rattus norvegicus	107-110
20398736-7	2010	Radioimmunoassay (RIA) was adopted to test the change of serum corticosterone (CORT).	Corticosterone	63-77	cortistatin	Rattus norvegicus	79-83
20353942-0	2010	Dysfunction of the Scn8a voltage-gated sodium channel alters sleep architecture, reduces diurnal corticosterone levels, and enhances spatial memory.	Corticosterone	97-111	sodium voltage-gated channel alpha subunit 8	Homo sapiens	19-24
20353942-7	2010	Compared with their wild-type littermates, Scn8a(med-jo/+) mutants experience more non-rapid eye movement (non-REM) sleep, a chronic impairment of REM sleep generation and quantity, and a lowered and flattened diurnal rhythm of corticosterone levels.	Corticosterone	228-242	sodium voltage-gated channel alpha subunit 8	Homo sapiens	43-48
20211972-2	2010	How different mediators of the stress response, such as corticosterone (CORT), influence these changes in risk remains unclear.	Corticosterone	56-70	cortistatin	Mus musculus	72-76
20171986-1	2010	A routine method of measuring circulating corticosterone (CORT) levels in rats involves sampling of plasma from cannulated animals.	Corticosterone	42-56	cortistatin	Rattus norvegicus	58-62
20372824-14	2010	GHREL infusion lowered plasma corticosterone concentration at day 5 but not 8 of the experiment, while OBS administration was ineffective.	Corticosterone	30-44	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-5
19965603-3	2010	Multivariate data analysis between wild-type and Fxr-null mice on a cholic acid diet revealed that the most increased ions were metabolites of p-cresol (4-methylphenol), corticosterone, and cholic acid in Fxr-null mice.	Corticosterone	170-184	nuclear receptor subfamily 1, group H, member 4	Mus musculus	49-52
19346277-6	2010	GAT-1 blockade induced a setpoint-shift of the stress hormone system toward lower levels as indicated by decreased plasma corticosterone concentrations and attenuated gene expression levels of corticotropin-releasing factor in the paraventricular nucleus of the hypothalamus and of hippocampal steroid receptors.	Corticosterone	122-136	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	0-5
20057176-5	2010	These results indicate that NO is generated by NOS 3 in the DA and that the age-dependant expression of NOS 3 in the premature DA is attributable to corticosterone-associated activity.	Corticosterone	149-163	nitric oxide synthase 3	Rattus norvegicus	104-109
20020182-3	2010	The serum corticosterone (CORT) level was measured, as an indicator of stress stimuli.	Corticosterone	10-24	cortistatin	Rattus norvegicus	26-30
20357208-5	2010	Aldosterone and dexamethasone, respectively, increased and suppressed mRNA/protein expression of brain-derived neurotrophic factor (BDNF) in rat cortical neuronal cells, whereas the endogenous glucocorticoid corticosterone showed a biphasic effect.	Corticosterone	208-222	brain-derived neurotrophic factor	Rattus norvegicus	97-130
20180019-2	2010	In the present study, the effect of corticosterone (CORT) on ATP-induced Ca(2+) mobilization in cultured dorsal root ganglion (DRG) neurons were detected with confocal laser scanning microscopy using fluo-4/AM as a calcium fluorescent indicator that could monitor real-time alterations of intracellular calcium concentration ([Ca(2+)]i).	Corticosterone	36-50	cortistatin	Homo sapiens	52-56
19958164-0	2010	Cytokine and chemokine gene expression profiles in heterophils from chickens treated with corticosterone.	Corticosterone	90-104	C-X-C motif chemokine ligand 13-like 2	Gallus gallus	13-22
19958164-3	2010	We recently demonstrated that exposure to corticosterone in drinking water for 1 week significantly upregulates mRNA expression levels for the pro-inflammatory interleukins (IL)-1beta, IL-6, IL-18 and the pro-inflammatory chemokine CCLi2 in chicken lymphocytes, particularly 3 h after the treatment started.	Corticosterone	42-56	interleukin 6	Gallus gallus	185-189
19958164-3	2010	We recently demonstrated that exposure to corticosterone in drinking water for 1 week significantly upregulates mRNA expression levels for the pro-inflammatory interleukins (IL)-1beta, IL-6, IL-18 and the pro-inflammatory chemokine CCLi2 in chicken lymphocytes, particularly 3 h after the treatment started.	Corticosterone	42-56	interleukin 18	Gallus gallus	191-196
19958164-3	2010	We recently demonstrated that exposure to corticosterone in drinking water for 1 week significantly upregulates mRNA expression levels for the pro-inflammatory interleukins (IL)-1beta, IL-6, IL-18 and the pro-inflammatory chemokine CCLi2 in chicken lymphocytes, particularly 3 h after the treatment started.	Corticosterone	42-56	C-X-C motif chemokine ligand 13-like 2	Gallus gallus	222-231
19958164-4	2010	In the present study, we investigated cytokine and chemokine mRNA expression levels in circulating heterophils of chickens, and show that at 3 h post initial treatment with corticosterone in drinking water (20 mg/1L) the mRNA expression levels for IL-1beta, IL-6, IL-10, IL-12alpha and IL-18 are upregulated.	Corticosterone	173-187	C-X-C motif chemokine ligand 13-like 2	Gallus gallus	51-60
19958164-4	2010	In the present study, we investigated cytokine and chemokine mRNA expression levels in circulating heterophils of chickens, and show that at 3 h post initial treatment with corticosterone in drinking water (20 mg/1L) the mRNA expression levels for IL-1beta, IL-6, IL-10, IL-12alpha and IL-18 are upregulated.	Corticosterone	173-187	interleukin 1, beta	Gallus gallus	248-256
19958164-4	2010	In the present study, we investigated cytokine and chemokine mRNA expression levels in circulating heterophils of chickens, and show that at 3 h post initial treatment with corticosterone in drinking water (20 mg/1L) the mRNA expression levels for IL-1beta, IL-6, IL-10, IL-12alpha and IL-18 are upregulated.	Corticosterone	173-187	interleukin 6	Gallus gallus	258-262
19958164-4	2010	In the present study, we investigated cytokine and chemokine mRNA expression levels in circulating heterophils of chickens, and show that at 3 h post initial treatment with corticosterone in drinking water (20 mg/1L) the mRNA expression levels for IL-1beta, IL-6, IL-10, IL-12alpha and IL-18 are upregulated.	Corticosterone	173-187	interleukin 10	Gallus gallus	264-269
19958164-4	2010	In the present study, we investigated cytokine and chemokine mRNA expression levels in circulating heterophils of chickens, and show that at 3 h post initial treatment with corticosterone in drinking water (20 mg/1L) the mRNA expression levels for IL-1beta, IL-6, IL-10, IL-12alpha and IL-18 are upregulated.	Corticosterone	173-187	interleukin 12A	Gallus gallus	271-281
19958164-4	2010	In the present study, we investigated cytokine and chemokine mRNA expression levels in circulating heterophils of chickens, and show that at 3 h post initial treatment with corticosterone in drinking water (20 mg/1L) the mRNA expression levels for IL-1beta, IL-6, IL-10, IL-12alpha and IL-18 are upregulated.	Corticosterone	173-187	interleukin 18	Gallus gallus	286-291
19958164-5	2010	The mRNA expression levels for IL-6, IL-10 and IL-18 correlate with plasma corticosterone concentration and total heterophil counts.	Corticosterone	75-89	interleukin 6	Gallus gallus	31-35
19958164-5	2010	The mRNA expression levels for IL-6, IL-10 and IL-18 correlate with plasma corticosterone concentration and total heterophil counts.	Corticosterone	75-89	interleukin 10	Gallus gallus	37-42
19958164-5	2010	The mRNA expression levels for IL-6, IL-10 and IL-18 correlate with plasma corticosterone concentration and total heterophil counts.	Corticosterone	75-89	interleukin 18	Gallus gallus	47-52
19958164-7	2010	Repeated treatment with corticosterone upregulated mRNA expression levels of transforming growth factor-beta4 and the chemokine CCL16.	Corticosterone	24-38	transforming growth factor beta 1	Gallus gallus	77-109
19958164-7	2010	Repeated treatment with corticosterone upregulated mRNA expression levels of transforming growth factor-beta4 and the chemokine CCL16.	Corticosterone	24-38	C-X-C motif chemokine ligand 13-like 2	Gallus gallus	118-127
20392192-10	2010	Testing in the EPM increased serum corticosterone level in all WT and CRFR2-KO mice.	Corticosterone	35-49	corticotropin releasing hormone receptor 2	Mus musculus	70-75
20392192-11	2010	Corticosterone increased in RRS CRFR1-KO mice compared with their controls.	Corticosterone	0-14	corticotropin releasing hormone receptor 1	Mus musculus	32-37
20138076-4	2010	We found a negative correlation between serum corticosterone (CORT) concentrations and litter size during two different stages of juvenile life.	Corticosterone	46-60	cortistatin	Rattus norvegicus	62-66
20379891-0	2010	Gene expression of hepatic glucocorticoid receptor NR3C1 and correlation with plasmatic corticosterone in Italian chickens.	Corticosterone	88-102	nuclear receptor subfamily 3 group C member 1	Gallus gallus	27-50
20079382-7	2010	Four hours after indomethacin treatment adrenocorticotropin and corticosterone levels as well as blood glucose levels were higher in VP-deficient rats, independent of the age.	Corticosterone	64-78	arginine vasopressin	Rattus norvegicus	133-135
20138850-3	2010	The hippocampus expresses particularly high levels of the alpha(1D) adrenergic receptor (ADR) and we have previously demonstrated that alpha(1d) ADR mRNA expression in the rat hippocampus is modulated by corticosterone.	Corticosterone	204-218	adrenoceptor alpha 1D	Rattus norvegicus	58-87
19923365-5	2010	Conversely, reduced serum corticosterone concentrations in these fetuses appear to result from alterations in gene expression involved in cholesterol metabolism, such as the augmented apolipoprotein E levels, and in steroidogenesis, like the decreased levels of cytochrome P45011beta-hydroxylase.	Corticosterone	26-40	apolipoprotein E	Rattus norvegicus	184-200
20233222-10	2010	injection of augurin significantly increased plasma ACTH and corticosterone, compared with vehicle-injected controls, but had no effect on other hypothalamo-pituitary axes hormones.	Corticosterone	61-75	ECRG4 augurin precursor	Rattus norvegicus	13-20
20233222-11	2010	Microinjection of lower doses of augurin into the PVN caused a similar increase in plasma ACTH and corticosterone, without significant alteration in behavioural patterns.	Corticosterone	99-113	ECRG4 augurin precursor	Rattus norvegicus	33-40
20070865-0	2010	Corticosterone up-regulates expression and function of norepinephrine transporter in SK-N-BE(2)C cells.	Corticosterone	0-14	solute carrier family 6 member 2	Rattus norvegicus	55-81
20070865-2	2010	In the present study, we examined the regulatory effect of corticosterone on the expression and function of the norepinephrine transporter (NET) in vitro.	Corticosterone	59-73	solute carrier family 6 member 2	Rattus norvegicus	112-138
20070865-2	2010	In the present study, we examined the regulatory effect of corticosterone on the expression and function of the norepinephrine transporter (NET) in vitro.	Corticosterone	59-73	solute carrier family 6 member 2	Rattus norvegicus	140-143
20070865-3	2010	The results show that exposure of SK-N-BE(2)C cells to corticosterone for 14 days significantly increased mRNA (up to 43%) and protein (up to 71%) levels of NET in the concentration-dependent manner.	Corticosterone	55-69	solute carrier family 6 member 2	Rattus norvegicus	157-160
20070865-5	2010	The up-regulatory effect of corticosterone on NET expression lasted a persistent period after cessation of exposure.	Corticosterone	28-42	solute carrier family 6 member 2	Rattus norvegicus	46-49
20070865-6	2010	Associated with the corticosterone-induced enhancement in NET expression, there was a parallel increase in the uptake of [(3)H]norepinephrine by SK-N-BE(2)C cells.	Corticosterone	20-34	solute carrier family 6 member 2	Rattus norvegicus	58-61
20070865-7	2010	Increased NET expression and function were abolished after exposure of cells to corticosterone in combination with mifepristone or spironolactone, two specific antagonists of corticosteroid receptors.	Corticosterone	80-94	solute carrier family 6 member 2	Rattus norvegicus	10-13
20070865-8	2010	This is consistent with the hypothesis that corticosterone-induced NET up-regulation is mediated by corticosteroid receptors.	Corticosterone	44-58	solute carrier family 6 member 2	Rattus norvegicus	67-70
20070865-10	2010	A similar up-regulation of NET protein levels was also observed after exposing PC12 cells to corticosterone.	Corticosterone	93-107	solute carrier family 6 member 2	Rattus norvegicus	27-30
20070865-11	2010	The present findings demonstrate that corticosterone up-regulates the expression and function of NET in vitro, indicating the action of corticosterone on the noradrenergic phenotype may play an important role in the correlation between stress and the development of depression.	Corticosterone	38-52	solute carrier family 6 member 2	Rattus norvegicus	97-100
20070865-11	2010	The present findings demonstrate that corticosterone up-regulates the expression and function of NET in vitro, indicating the action of corticosterone on the noradrenergic phenotype may play an important role in the correlation between stress and the development of depression.	Corticosterone	136-150	solute carrier family 6 member 2	Rattus norvegicus	97-100
20379891-0	2010	Gene expression of hepatic glucocorticoid receptor NR3C1 and correlation with plasmatic corticosterone in Italian chickens.	Corticosterone	88-102	nuclear receptor subfamily 3 group C member 1	Gallus gallus	51-56
19763091-5	2010	11betaHSD1 converts inert cortisone, or 11-dehydrocorticosterone in rats into active cortisol and corticosterone.	Corticosterone	50-64	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-10
20132473-6	2010	Similarly, corticosterone treatment of astrocytes caused a reduction of constitutive as well as the NA-induced MCP-1 production.	Corticosterone	11-25	C-C motif chemokine ligand 2	Rattus norvegicus	111-116
20308419-4	2010	Central administration of CRH compared with AVT is more effective in releasing the stress hormone corticosterone, whereas peripheral administration of AVT is more efficacious.	Corticosterone	98-112	corticotropin releasing hormone	Homo sapiens	26-29
20308419-5	2010	Simultaneous, peripheral administration of CRH and AVT also resulted in a synergistic release of corticosterone.	Corticosterone	97-111	corticotropin releasing hormone	Homo sapiens	43-46
20308419-6	2010	Cell culture studies demonstrated a synergistic release of the second messenger, cyclic adenosine monophosphate, when both CRH and AVT were added to cells transfected with CRH and VT2 receptors, providing a possible explanation for the enhanced release of corticosterone following combined peripheral administration of the 2 peptides.	Corticosterone	256-270	corticotropin releasing hormone	Homo sapiens	123-126
20308419-6	2010	Cell culture studies demonstrated a synergistic release of the second messenger, cyclic adenosine monophosphate, when both CRH and AVT were added to cells transfected with CRH and VT2 receptors, providing a possible explanation for the enhanced release of corticosterone following combined peripheral administration of the 2 peptides.	Corticosterone	256-270	corticotropin releasing hormone	Homo sapiens	172-175
20308420-8	2010	We have evaluated the effects of corticosterone administration in drinking water on peripheral lymphocyte and heterophil cytokine and chemokine gene profiles.	Corticosterone	33-47	C-X-C motif chemokine ligand 13-like 2	Gallus gallus	134-143
19766402-0	2010	Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR+/- mice.	Corticosterone	69-83	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	39-56
19766402-5	2010	Corticosterone treatment (10mg/kg, sc once daily for 21 days) of wild-type mice resulted in a decrease in 5-HT(1A) receptor function in prefrontal cortex [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 39+/-4.9; corticosterone-treated: 17+/-2.8], but not in hippocampus.	Corticosterone	0-14	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	106-123
19766402-5	2010	Corticosterone treatment (10mg/kg, sc once daily for 21 days) of wild-type mice resulted in a decrease in 5-HT(1A) receptor function in prefrontal cortex [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 39+/-4.9; corticosterone-treated: 17+/-2.8], but not in hippocampus.	Corticosterone	245-259	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	106-123
19766402-6	2010	The constitutive reduction in GR expression prevented the down-regulation of 5-HT(1A) receptor function in frontal cortex by chronic corticosterone administration.	Corticosterone	133-147	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	77-94
19766402-7	2010	In contrast, corticosterone treatment of GR+/- mice resulted in an increase in 5-HT(1A) receptor function in hippocampus which reached statistical significance in CA2/3 region [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 41+/-9.7; corticosterone-treated: 94+/-23].	Corticosterone	13-27	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	79-96
19766402-7	2010	In contrast, corticosterone treatment of GR+/- mice resulted in an increase in 5-HT(1A) receptor function in hippocampus which reached statistical significance in CA2/3 region [8-OH-DPAT-stimulated [(35)S]GTPgammaS binding (% above basal), vehicle-treated: 41+/-9.7; corticosterone-treated: 94+/-23].	Corticosterone	267-281	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	79-96
19766402-9	2010	Although GR+/- mice do not exhibit changes in baseline corticosterone, the constitutive deficiency in GR appears to have unmasked regulatory effects of elevated corticosterone in the maintenance of 5-HT(1A) receptor function in prefrontal cortex and hippocampus.	Corticosterone	161-175	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	198-215
20394311-13	2010	injected CRH increased plasma corticosterone levels in both CL and CKO mice.	Corticosterone	30-44	corticotropin releasing hormone	Mus musculus	9-12
19896506-9	2010	The S180 dams also had increased plasma corticosterone concentration compared to S15 dams, which coincided with increased hypothalamic CRH mRNA and reduced hippocampal GR mRNA expression, suggesting possible dysregulation of hypothalamic-pituitary-adrenal axis activity.	Corticosterone	40-54	corticotropin releasing hormone	Rattus norvegicus	135-138
19932127-4	2010	Plasma corticosterone (CORT) was measured after a) acute restraint and OF testing and b) FST.	Corticosterone	7-21	cortistatin	Homo sapiens	23-27
19100597-0	2010	Single-dose and chronic corticosterone treatment alters c-Fos or FosB immunoreactivity in the rat cerebral cortex.	Corticosterone	24-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-61
19100597-0	2010	Single-dose and chronic corticosterone treatment alters c-Fos or FosB immunoreactivity in the rat cerebral cortex.	Corticosterone	24-38	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-69
19100597-1	2010	The aim of this study was to examine the effects of single-dose and chronic corticosterone treatment on the inducible transcription factor c-Fos and FosB, and thereby to estimate the effects of high-doses of corticosterone on calcium-dependent neuronal responses in the rat cerebral cortex.	Corticosterone	76-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	139-144
19100597-1	2010	The aim of this study was to examine the effects of single-dose and chronic corticosterone treatment on the inducible transcription factor c-Fos and FosB, and thereby to estimate the effects of high-doses of corticosterone on calcium-dependent neuronal responses in the rat cerebral cortex.	Corticosterone	76-90	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	149-153
19100597-10	2010	It was found that a single-dose administration of corticosterone resulted in a significant, time-dependent increase of c-Fos protein immunoreactivity in the granule cell layer of the dentate gyrus, as well as in regions CA1 and CA3 of the hippocampus 12 and 24h post-injection with respect to control animals.	Corticosterone	50-64	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
19100597-10	2010	It was found that a single-dose administration of corticosterone resulted in a significant, time-dependent increase of c-Fos protein immunoreactivity in the granule cell layer of the dentate gyrus, as well as in regions CA1 and CA3 of the hippocampus 12 and 24h post-injection with respect to control animals.	Corticosterone	50-64	carbonic anhydrase 1	Rattus norvegicus	220-223
19100597-10	2010	It was found that a single-dose administration of corticosterone resulted in a significant, time-dependent increase of c-Fos protein immunoreactivity in the granule cell layer of the dentate gyrus, as well as in regions CA1 and CA3 of the hippocampus 12 and 24h post-injection with respect to control animals.	Corticosterone	50-64	carbonic anhydrase 3	Rattus norvegicus	228-231
19100597-13	2010	Repeated administration of corticosterone produced a complex pattern of changes in FosB immunolabelling: significant increase in FosB immunoreactivity was detected in the granule cell layer of the dentate gyrus, with no significant changes in the CA1 and CA3 layers of the hippocampus and in the neocortex.	Corticosterone	27-41	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-87
19100597-13	2010	Repeated administration of corticosterone produced a complex pattern of changes in FosB immunolabelling: significant increase in FosB immunoreactivity was detected in the granule cell layer of the dentate gyrus, with no significant changes in the CA1 and CA3 layers of the hippocampus and in the neocortex.	Corticosterone	27-41	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	129-133
19100597-13	2010	Repeated administration of corticosterone produced a complex pattern of changes in FosB immunolabelling: significant increase in FosB immunoreactivity was detected in the granule cell layer of the dentate gyrus, with no significant changes in the CA1 and CA3 layers of the hippocampus and in the neocortex.	Corticosterone	27-41	carbonic anhydrase 1	Rattus norvegicus	247-250
19100597-13	2010	Repeated administration of corticosterone produced a complex pattern of changes in FosB immunolabelling: significant increase in FosB immunoreactivity was detected in the granule cell layer of the dentate gyrus, with no significant changes in the CA1 and CA3 layers of the hippocampus and in the neocortex.	Corticosterone	27-41	carbonic anhydrase 3	Rattus norvegicus	255-258
19100597-18	2010	The present data suggest that single-dose corticosterone treatment increases immunoreactivity of c-Fos protein in a time-dependent manner, 12 and 24h post-injection in the rat hippocampus and the neocortex, whereas chronic corticosterone treatment influences FosB immunoreactivity, primarily in the dentate gyrus.	Corticosterone	42-56	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
19100597-18	2010	The present data suggest that single-dose corticosterone treatment increases immunoreactivity of c-Fos protein in a time-dependent manner, 12 and 24h post-injection in the rat hippocampus and the neocortex, whereas chronic corticosterone treatment influences FosB immunoreactivity, primarily in the dentate gyrus.	Corticosterone	42-56	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	259-263
19100597-19	2010	Chronic corticosterone administration seems to affect CR levels in the CA3 area of the hippocampus.	Corticosterone	8-22	calbindin 2	Rattus norvegicus	54-56
19100597-19	2010	Chronic corticosterone administration seems to affect CR levels in the CA3 area of the hippocampus.	Corticosterone	8-22	carbonic anhydrase 3	Rattus norvegicus	71-74
19508587-9	2010	Compared with normal controls, carriers showed lower basal and ACTH-stimulated cortisol levels but higher ACTH-stimulated corticosterone levels.	Corticosterone	122-136	proopiomelanocortin	Homo sapiens	106-110
20080870-2	2010	Here we hypothesized that such sustained glucocorticoid levels, disturbing corticosterone pulsatility, attenuate glucocorticoid receptor signaling and target gene responsiveness to an acute challenge in the rat brain.	Corticosterone	75-89	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	113-136
20080870-6	2010	Implantation of 40 and 100% corticosterone pellets dose-dependently down-regulated glucocorticoid receptor and attenuated mineralocorticoid receptor and glucocorticoid receptor translocation to the acute challenge.	Corticosterone	28-42	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	83-106
20080870-6	2010	Implantation of 40 and 100% corticosterone pellets dose-dependently down-regulated glucocorticoid receptor and attenuated mineralocorticoid receptor and glucocorticoid receptor translocation to the acute challenge.	Corticosterone	28-42	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	153-176
20127047-11	2010	These results suggest that the GR gene polymorphism has a significant impact on the stress-induced output, including the gastric lesion index, corticosterone, cytokines, and Hsp70 levels in serum.	Corticosterone	143-157	nuclear receptor subfamily 3, group C, member 1	Mus musculus	31-33
20045034-11	2010	In prolonged exposure of adrenocortical cell primary cultures to SPX (10-6M) resulted in a small increase in corticosterone secretion and a notable decrease in BrdU incorporation.	Corticosterone	109-123	spexin hormone	Rattus norvegicus	65-68
20132869-2	2010	Corticotropin-releasing factor (CRF)-overexpressing (OE) mice are a genetic model of chronic stress with elevated brain CRF and plasma corticosterone levels and Cushing"s syndrome.	Corticosterone	135-149	corticotropin releasing hormone	Mus musculus	0-30
20035838-11	2010	Endogenous NT regulates hypothalamic-pituitary-adrenal axis activity in stress condition by increasing corticosterone plasma levels.	Corticosterone	103-117	neurotensin	Mus musculus	11-13
20035838-16	2010	Our results also revealed that the release of endogenous NT in response to stress requires the presence of NTS2 to stimulate corticotropin-releasing factor (CRF)-induced elevation of plasma corticosterone, and that NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.	Corticosterone	190-204	neurotensin	Mus musculus	57-59
20035838-16	2010	Our results also revealed that the release of endogenous NT in response to stress requires the presence of NTS2 to stimulate corticotropin-releasing factor (CRF)-induced elevation of plasma corticosterone, and that NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.	Corticosterone	190-204	nuclear encoded tRNA selenocysteine 2 (anticodon TCA)	Mus musculus	107-111
20035838-16	2010	Our results also revealed that the release of endogenous NT in response to stress requires the presence of NTS2 to stimulate corticotropin-releasing factor (CRF)-induced elevation of plasma corticosterone, and that NTS2 receptors localized at the lumbar spinal cord participate to the disinhibition of descending pain control pathways.	Corticosterone	190-204	corticotropin releasing hormone	Mus musculus	125-155
20032461-6	2010	Under PPARalpha activation, the classic reductive metabolic pathway of corticosterone was suppressed, whereas an alternative oxidative pathway was uncovered that leads to the sequential oxidation on carbon 21 resulting in HDOPA.	Corticosterone	71-85	peroxisome proliferator activated receptor alpha	Mus musculus	6-15
20004715-5	2010	Moreover, stressor-induced elevations of corticosterone and the pro-inflammatory cytokine, tumor necrosis factor-alpha, were attenuated in IFN-gamma-deficient mice.	Corticosterone	41-55	interferon gamma	Mus musculus	139-148
20155810-1	2010	Upregulation of haptoglobin (Hp) expression in the rat during the acute phase (AP) response is the result of synergistic effects of IL-6-, IL-1beta-, and corticosterone-activated signaling pathways.	Corticosterone	154-168	haptoglobin	Rattus norvegicus	16-27
20051515-0	2010	The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex.	Corticosterone	19-33	serum/glucocorticoid regulated kinase 1	Homo sapiens	131-173
19932757-7	2010	These findings indicate that noradrenergic activity at BLA beta-adrenoceptors is involved in corticosterone-induced enhancement of memory consolidation and expression of the synaptic-plasticity-related protein Arc in the hippocampus.	Corticosterone	93-107	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	210-213
19932757-0	2010	Memory-enhancing corticosterone treatment increases amygdala norepinephrine and Arc protein expression in hippocampal synaptic fractions.	Corticosterone	17-31	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	80-83
19932757-5	2010	Corticosterone increased amygdala norepinephrine levels 15 min after inhibitory avoidance training, as assessed by in vivo microdialysis, and enhanced memory tested at 48 h. Corticosterone treatment also increased expression of Arc protein in hippocampal synaptic tissue.	Corticosterone	0-14	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	228-231
19932757-5	2010	Corticosterone increased amygdala norepinephrine levels 15 min after inhibitory avoidance training, as assessed by in vivo microdialysis, and enhanced memory tested at 48 h. Corticosterone treatment also increased expression of Arc protein in hippocampal synaptic tissue.	Corticosterone	174-188	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	228-231
19932757-6	2010	The elevation in BLA norepinephrine appears to participate in corticosterone-influenced modulation of hippocampal Arc expression as intra-BLA blockade of beta-adrenoceptors with propranolol (0.5 microg/0.2 microL) attenuated the corticosterone-induced synaptic Arc expression in the hippocampus.	Corticosterone	62-76	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	114-117
20051515-0	2010	The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex.	Corticosterone	19-33	serum/glucocorticoid regulated kinase 1	Homo sapiens	175-178
20051515-0	2010	The stress hormone corticosterone increases synaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors via serum- and glucocorticoid-inducible kinase (SGK) regulation of the GDI-Rab4 complex.	Corticosterone	19-33	RAB4A, member RAS oncogene family	Homo sapiens	202-206
20051515-3	2010	This enhancing effect of corticosterone is through a mechanism dependent on Rab4, the small GTPase-controlling receptor recycling between early endosome and plasma membrane.	Corticosterone	25-39	RAB4A, member RAS oncogene family	Homo sapiens	76-80
20051515-4	2010	Guanosine nucleotide dissociation inhibitor (GDI), which regulates the cycle of Rab proteins between membrane and cytosol, forms an increased complex with Rab4 after corticosterone treatment.	Corticosterone	166-180	RAB4A, member RAS oncogene family	Homo sapiens	80-83
20051515-4	2010	Guanosine nucleotide dissociation inhibitor (GDI), which regulates the cycle of Rab proteins between membrane and cytosol, forms an increased complex with Rab4 after corticosterone treatment.	Corticosterone	166-180	RAB4A, member RAS oncogene family	Homo sapiens	155-159
20051515-5	2010	Corticosterone also triggers an increased GDI phosphorylation at Ser-213 by the serum- and glucocorticoid-inducible kinase (SGK).	Corticosterone	0-14	serum/glucocorticoid regulated kinase 1	Homo sapiens	80-122
20051515-5	2010	Corticosterone also triggers an increased GDI phosphorylation at Ser-213 by the serum- and glucocorticoid-inducible kinase (SGK).	Corticosterone	0-14	serum/glucocorticoid regulated kinase 1	Homo sapiens	124-127
20051515-7	2010	These results suggest that corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.	Corticosterone	27-41	serum/glucocorticoid regulated kinase 1	Homo sapiens	47-50
20051515-7	2010	These results suggest that corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.	Corticosterone	27-41	RAB4A, member RAS oncogene family	Homo sapiens	117-121
20051515-7	2010	These results suggest that corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.	Corticosterone	27-41	RAB4A, member RAS oncogene family	Homo sapiens	168-172
20051515-7	2010	These results suggest that corticosterone, via SGK phosphorylation of GDI at Ser-213, increases the formation of GDI-Rab4 complex, facilitating the functional cycle of Rab4 and Rab4-mediated recycling of AMPARs to the synaptic membrane.	Corticosterone	27-41	RAB4A, member RAS oncogene family	Homo sapiens	168-172
19931358-10	2010	Our results suggest that sustained corticosterone secretion, synthesis of the hypophysiotropic hormone CRH in the hypothalamus, and synthesis of the enzymes producing the hormone adrenaline in the adrenal medulla, are controlled by PACAP signaling in the mouse.	Corticosterone	35-49	adenylate cyclase activating polypeptide 1	Mus musculus	232-237
19362431-11	2010	Pretreatment of sPLA2 inhibitor significantly reduced the severity of pancreatitis and adrenal histological injury, improved the 24-h serum corticosterone levels, and effectively inhibited sPLA2 activity and sPLA2-IIA expression in adrenal glands.	Corticosterone	140-154	phospholipase A2 group IIA	Rattus norvegicus	16-21
19819265-6	2010	Experiment 3 found that group-housed females had higher baseline corticosterone (CORT) levels than isolated females and fluoxetine had no effect on CORT levels.	Corticosterone	65-79	cortistatin	Mus musculus	81-85
20034541-0	2010	Cyclooxygenase-1 mediates the immediate corticosterone response to peripheral immune challenge induced by lipopolysaccharide.	Corticosterone	40-54	prostaglandin-endoperoxide synthase 1	Mus musculus	0-16
20034541-3	2010	We found that mice with a deletion of the gene encoding cyclooxygenase-1, in contrast to wild type mice, did not show increased plasma corticosterone at 1h after immune challenge by peripheral injection of bacterial wall lipopolysaccharide, whereas the corticosterone levels were similarly elevated in both genotypes at 6h post-injection.	Corticosterone	253-267	prostaglandin-endoperoxide synthase 1	Mus musculus	56-72
20034541-4	2010	Pretreatment of mice with the selective cyclooxygenase-1 inhibitor SC-560, given orally, likewise inhibited the rapid corticosterone response.	Corticosterone	118-132	prostaglandin-endoperoxide synthase 1	Mus musculus	40-56
20095093-1	2010	CONCLUSIONS: 11beta-Hydroxysteroid dehydrogenase type 2 (11bHSD-2) enables aldosterone to bind to mineralocorticoid receptors (MRs) selectively by converting cortisol (corticosterone) into inactive metabolites.	Corticosterone	168-182	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	13-55
20069608-5	2010	Mifepristone was used to determine the role of glucocorticoid receptor in the corticosterone-induced ER stress response.	Corticosterone	78-92	nuclear receptor subfamily 3 group C member 1	Homo sapiens	47-70
20069608-9	2010	Expression of X box-binding protein (XBP) 1, but not activating transcription factor 6, was significantly increased at both mRNA and protein levels only in the presence of low-dose corticosterone.	Corticosterone	181-195	X-box binding protein 1	Homo sapiens	14-43
20069608-10	2010	Inhibition of XBP1 expression with small interfering RNA significantly inhibited the corticosterone immunostimulatory effects.	Corticosterone	85-99	X-box binding protein 1	Homo sapiens	14-18
20069608-11	2010	In addition, pretreatment of macrophages with mifepristone significantly inhibited the expression of glucose response protein 78 and XBP1 in macrophages by low-dose corticosterone.	Corticosterone	165-179	X-box binding protein 1	Homo sapiens	133-137
20022933-6	2010	Interestingly, free corticosterone concentrations are normal at rest but present a reduced surge after stress in transcortin-deficient mice.	Corticosterone	20-34	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	113-124
19674922-9	2010	Indomethacin resulted in a sustained elevation in corticosterone levels at P21, while ibuprofen increased serum and hepatic GH levels.	Corticosterone	50-64	KRAS proto-oncogene, GTPase	Rattus norvegicus	75-78
19862666-6	2010	Furthermore, anandamide inhibited basal release and stimulated release of adrenocortical steroids (corticosterone and aldosterone); this effect was reversed by CB1 antagonist (SR141716A).	Corticosterone	99-113	cannabinoid receptor 1	Homo sapiens	160-163
19959768-0	2010	Effects of excess corticosterone on LKB1 and AMPK signaling in rat skeletal muscle.	Corticosterone	18-32	serine/threonine kinase 11	Rattus norvegicus	36-40
19948178-2	2010	The rat liver microsome fraction was prepared and 11beta-HSD1 activity was assayed using cortisol and corticosterone as substrates for the enzyme reaction.	Corticosterone	102-116	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	50-61
20098621-5	2010	Caveolin-1 was strongly responsive in several organs, and the HRE pair in its upstream region showed increased occupancy by glucocorticoid receptor in response to corticosterone.	Corticosterone	163-177	caveolin 1, caveolae protein	Mus musculus	0-10
20098621-5	2010	Caveolin-1 was strongly responsive in several organs, and the HRE pair in its upstream region showed increased occupancy by glucocorticoid receptor in response to corticosterone.	Corticosterone	163-177	nuclear receptor subfamily 3, group C, member 1	Mus musculus	124-147
19808775-6	2010	The corticosterone response to a CRH or ACTH challenge and a forced swim test was more distinct in TGR(ASrAOGEN) than it was in controls and occurred independently of a concurrent enhancement in ACTH.	Corticosterone	4-18	corticotropin releasing hormone	Rattus norvegicus	33-36
20016090-2	2009	Maternal odor learning occurs using a simple learning circuit including robust olfactory bulb norepinephrine (NE), release from the locus ceruleus (LC), and amygdala suppression by low corticosterone (CORT).	Corticosterone	185-199	cortistatin	Rattus norvegicus	201-205
19782125-0	2010	Repeated restraint stress and corticosterone injections during late pregnancy alter GAP-43 expression in the hippocampus and prefrontal cortex of rat pups.	Corticosterone	30-44	growth associated protein 43	Rattus norvegicus	84-90
19939912-10	2010	Furthermore, in the presence of an acute GR knockdown as well as in GR knockout adipocytes, corticosterone increased the gene expression of the pro-inflammatory adipokines IL6 and MCP1.	Corticosterone	92-106	nuclear receptor subfamily 3 group C member 1	Homo sapiens	41-43
19939912-10	2010	Furthermore, in the presence of an acute GR knockdown as well as in GR knockout adipocytes, corticosterone increased the gene expression of the pro-inflammatory adipokines IL6 and MCP1.	Corticosterone	92-106	nuclear receptor subfamily 3 group C member 1	Homo sapiens	68-70
19939912-10	2010	Furthermore, in the presence of an acute GR knockdown as well as in GR knockout adipocytes, corticosterone increased the gene expression of the pro-inflammatory adipokines IL6 and MCP1.	Corticosterone	92-106	interleukin 6	Homo sapiens	172-175
19939912-10	2010	Furthermore, in the presence of an acute GR knockdown as well as in GR knockout adipocytes, corticosterone increased the gene expression of the pro-inflammatory adipokines IL6 and MCP1.	Corticosterone	92-106	C-C motif chemokine ligand 2	Homo sapiens	180-184
19890264-4	2010	In cell cultures, corticosterone has been shown to condition the synaptic trafficking of the AMPAR GluA2 subunit.	Corticosterone	18-32	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	99-104
19733225-7	2010	Corticosterone caused a concentration-dependent inhibition of ERK-1/2 activation, with the highest concentration resulting in considerable inhibition of oocyte ERK-1/2 phosphorylation and no blastocyst development.	Corticosterone	0-14	mitogen-activated protein kinase 3	Mus musculus	62-69
19733225-7	2010	Corticosterone caused a concentration-dependent inhibition of ERK-1/2 activation, with the highest concentration resulting in considerable inhibition of oocyte ERK-1/2 phosphorylation and no blastocyst development.	Corticosterone	0-14	mitogen-activated protein kinase 3	Mus musculus	160-167
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	137-151	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	53-64
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	137-151	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	153-157	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	53-64
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	153-157	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	218-222	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	53-64
20045394-1	2010	Two isoforms of 11beta-hydroxysteroid dehydrogenase (11beta-HSD1 and 11beta-HSD2) play an important role in regulation of glucocorticoid corticosterone (CORT, the active form in rodents) by the interconversion between CORT and 11-dehydrocorticosterone (11DHC, the biologically inert form).	Corticosterone	218-222	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	69-80
20052403-6	2010	Stress induced rapid increase in the circulating levels of corticosterone in all rats (both vehicle- and drug-treated), and glutamate release increase was blocked by previous administration of selective antagonist of glucocorticoid receptor (RU 486).	Corticosterone	59-73	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	217-240
20052403-10	2010	Stress-induced increase of glutamate release was dependent on stimulation of glucocorticoid receptor by corticosterone.	Corticosterone	104-118	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	77-100
19799583-2	2010	Corticosterone is proposed to modulate cocaine intravenous self-administration (SA) and cocaine-induced locomotion through distinct receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), respectively.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Mus musculus	147-170
19799583-2	2010	Corticosterone is proposed to modulate cocaine intravenous self-administration (SA) and cocaine-induced locomotion through distinct receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), respectively.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Mus musculus	172-174
19799583-2	2010	Corticosterone is proposed to modulate cocaine intravenous self-administration (SA) and cocaine-induced locomotion through distinct receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), respectively.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Mus musculus	184-210
19799583-2	2010	Corticosterone is proposed to modulate cocaine intravenous self-administration (SA) and cocaine-induced locomotion through distinct receptors, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), respectively.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Mus musculus	212-214
19799583-5	2010	On the other hand, modulation of both responses by the MR was never tested directly but only inferred based on the ability of low plasma corticosterone levels (those for which corticosterone almost exclusively binds the MR) to compensate the effects of adrenalectomy.	Corticosterone	137-151	nuclear receptor subfamily 3, group C, member 2	Mus musculus	55-57
19799583-5	2010	On the other hand, modulation of both responses by the MR was never tested directly but only inferred based on the ability of low plasma corticosterone levels (those for which corticosterone almost exclusively binds the MR) to compensate the effects of adrenalectomy.	Corticosterone	176-190	nuclear receptor subfamily 3, group C, member 2	Mus musculus	55-57
19833863-2	2010	Corticosterone takes part in the mechanisms that govern development, and its effects are regulated in particular by corticosterone-binding globulin (CBG) and glucocorticoid receptor (GR).	Corticosterone	0-14	serpin family A member 6	Rattus norvegicus	149-152
19833863-2	2010	Corticosterone takes part in the mechanisms that govern development, and its effects are regulated in particular by corticosterone-binding globulin (CBG) and glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	158-181
19833863-2	2010	Corticosterone takes part in the mechanisms that govern development, and its effects are regulated in particular by corticosterone-binding globulin (CBG) and glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	183-185
19833863-2	2010	Corticosterone takes part in the mechanisms that govern development, and its effects are regulated in particular by corticosterone-binding globulin (CBG) and glucocorticoid receptor (GR).	Corticosterone	116-130	serpin family A member 6	Rattus norvegicus	149-152
20015040-2	2010	The oxidoreductase 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) mainly catalyzes the intracellular regeneration of active GCs (cortisol, corticosterone) from inert inactive 11-keto forms (cortisone) in liver, adipose tissue and brain, amplifying local GC action.	Corticosterone	149-163	RNA, U1 small nuclear 1	Homo sapiens	4-74
19648477-1	2010	The mineralocorticoid receptor (MR) has been called a promiscuous receptor because its intrinsic affinity for aldosterone, cortisol and corticosterone is similar.	Corticosterone	136-150	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
19648477-1	2010	The mineralocorticoid receptor (MR) has been called a promiscuous receptor because its intrinsic affinity for aldosterone, cortisol and corticosterone is similar.	Corticosterone	136-150	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
20694669-3	2010	GR and MR predominantly reside in the cytoplasm in the absence of corticosterone (CORT), but are quickly translocated into the nucleus upon binding CORT.	Corticosterone	66-80	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-2
20694669-3	2010	GR and MR predominantly reside in the cytoplasm in the absence of corticosterone (CORT), but are quickly translocated into the nucleus upon binding CORT.	Corticosterone	66-80	nuclear receptor subfamily 3 group C member 2	Homo sapiens	7-9
19887855-9	2010	In contrast, the growth response to AngII was augmented following co-expression of AT(2) and AT(1) receptors (149.2 +/- 4.2%), which was reduced by approximately 20% in the presence of either corticosterone or dexamethasone (p &lt; 0.05).	Corticosterone	192-206	angiotensinogen	Homo sapiens	36-41
19878661-8	2009	Furthermore, adiponectin acutely reduced basal levels of corticosterone and aldosterone secretion.	Corticosterone	57-71	adiponectin, C1Q and collagen domain containing	Mus musculus	13-24
19656124-4	2009	RESULTS: Reducing maternal corticosterone (mCORT) during gestation led to alterations in dopamine and serotonin levels in all three brain areas studied at PN 23.	Corticosterone	27-41	cortistatin	Mus musculus	43-48
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	63-77	wingless-type MMTV integration site family, member 7B	Mus musculus	14-19
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	63-77	wingless-type MMTV integration site family, member 10B	Mus musculus	24-30
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	79-81	wingless-type MMTV integration site family, member 7B	Mus musculus	14-19
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	79-81	wingless-type MMTV integration site family, member 10B	Mus musculus	24-30
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	148-150	wingless-type MMTV integration site family, member 7B	Mus musculus	14-19
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	148-150	wingless-type MMTV integration site family, member 10B	Mus musculus	24-30
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	148-150	wingless-type MMTV integration site family, member 7B	Mus musculus	14-19
19876584-6	2009	Expression of Wnt7b and Wnt10b in osteoblasts was modulated by corticosterone (CS), in a biphasic fashion with 3- to 3.5-fold upregulation at 10 nM CS (P &lt; 0.01) and 50% downregulation at 100 nM CS (P &lt; 0.05).	Corticosterone	148-150	wingless-type MMTV integration site family, member 10B	Mus musculus	24-30
19876584-7	2009	CS 100 nM also increased expression of the Wnt inhibitors sFRP-1 and DKK-1 two- to threefold (P &lt; 0.05).	Corticosterone	0-2	wingless-type MMTV integration site family, member 2	Mus musculus	43-46
19876584-7	2009	CS 100 nM also increased expression of the Wnt inhibitors sFRP-1 and DKK-1 two- to threefold (P &lt; 0.05).	Corticosterone	0-2	secreted frizzled-related protein 1	Mus musculus	58-64
19876584-7	2009	CS 100 nM also increased expression of the Wnt inhibitors sFRP-1 and DKK-1 two- to threefold (P &lt; 0.05).	Corticosterone	0-2	dickkopf WNT signaling pathway inhibitor 1	Mus musculus	69-74
19664909-3	2009	However, the role of corticosterone (CORT) in effects of EE is still unknown.	Corticosterone	21-35	cortistatin	Mus musculus	37-41
19505571-2	2009	Corticosterone (CORT)-treated rats have emerged as a pharmacological model of depression-like behaviors.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
19710634-6	2009	Pharmacological inhibition of FAAH activity within the basolateral amygdala complex (BLA) attenuated stress-induced corticosterone secretion; this effect was blocked by co-administration of the CB(1) receptor antagonist AM251, suggesting that stress-induced decreases in CB(1) receptor activation by AEA contribute to activation of the neuroendocrine stress response.	Corticosterone	116-130	fatty-acid amide hydrolase-like	Rattus norvegicus	30-34
19837912-2	2009	11Beta-HSD1 is widely expressed and increases glucocorticoid action through its unique ability to convert inactive glucocorticoids (cortisone in man, 11-dehydrocorticosterone in rodents) to their active forms (cortisol and corticosterone, respectively).	Corticosterone	160-174	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	0-11
19723563-12	2009	Moreover, a negative association between corticosterone and BDNF was observed in both sexes.	Corticosterone	41-55	brain-derived neurotrophic factor	Rattus norvegicus	60-64
19720048-4	2009	Interestingly, MEHP inhibited Hsd11b2 mRNA level and 11beta-HSD2 enzyme activity in LbetaT2 cells at as low as 10(-7)M. Corticosterone (CORT) at a concentration of 10(-6)M significantly inhibited LbetaT2 cell proliferation after 2-day culture, and 10(-6)M RU486, an antagonist of glucocorticoid receptor (GR), reversed this inhibition.	Corticosterone	120-134	cortistatin	Mus musculus	136-140
19912621-0	2009	Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level.	Corticosterone	106-120	protein kinase C, iota	Mus musculus	49-53
19912621-0	2009	Anti-depressant and anxiolytic like behaviors in PKCI/HINT1 knockout mice associated with elevated plasma corticosterone level.	Corticosterone	106-120	histidine triad nucleotide binding protein 1	Mus musculus	54-59
19912621-12	2009	Furthermore, the afternoon basal plasma corticosterone level in PKCI/HINT1 KO mice was significantly higher than in the WT.	Corticosterone	40-54	protein kinase C, iota	Mus musculus	64-68
19912621-12	2009	Furthermore, the afternoon basal plasma corticosterone level in PKCI/HINT1 KO mice was significantly higher than in the WT.	Corticosterone	40-54	histidine triad nucleotide binding protein 1	Mus musculus	69-74
19912621-13	2009	CONCLUSION: PKCI/HINT1 KO mice displayed a phenotype of behavioral and endocrine features which indicate changes of mood function, including anxiolytic-like and anti-depressant like behaviors, in conjunction with an elevated corticosterone level in plasma.	Corticosterone	225-239	protein kinase C, iota	Mus musculus	12-16
19912621-13	2009	CONCLUSION: PKCI/HINT1 KO mice displayed a phenotype of behavioral and endocrine features which indicate changes of mood function, including anxiolytic-like and anti-depressant like behaviors, in conjunction with an elevated corticosterone level in plasma.	Corticosterone	225-239	histidine triad nucleotide binding protein 1	Mus musculus	17-22
19675138-2	2009	Within skeletal muscle, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone (11-dehydrocorticosterone in rodents) to active cortisol (corticosterone in rodents).	Corticosterone	111-125	RNA, U1 small nuclear 1	Homo sapiens	7-79
19666116-3	2009	Fmr1 knockout (KO) mice exhibited reduced anxiety on two behavioral tests as well as a blunted corticosterone response to acute stress.	Corticosterone	95-109	fragile X messenger ribonucleoprotein 1	Mus musculus	0-4
19690231-1	2009	Previously, we reported that atrazine (ATR) alters steroidogenesis in male Wistar rats resulting in elevated serum corticosterone (CORT), progesterone, and estrogens.	Corticosterone	115-129	cortistatin	Rattus norvegicus	131-135
19446600-5	2009	Up-regulation of NPY augmented plasma corticosterone levels and suppressed pituitary growth hormone (GH) expression, thereby modulating adipocytokine production to induce tissue-specific insulin sensitivity.	Corticosterone	38-52	neuropeptide Y	Rattus norvegicus	17-20
19332034-4	2009	First, corticosterone can quickly raise the excitability of hippocampal CA1 neurons shortly after stress exposure, via a nongenomic pathway involving mineralocorticoid receptors presumably located in the pre- as well as postsynaptic membrane.	Corticosterone	7-21	carbonic anhydrase 1	Homo sapiens	72-75
19368803-2	2009	In this study, we have investigated the dose-dependent effects of corticosterone on nuclear GR and GR-DNA binding in the brain and pituitary of adult adrenalectomized male rats.	Corticosterone	66-80	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	92-94
19368803-2	2009	In this study, we have investigated the dose-dependent effects of corticosterone on nuclear GR and GR-DNA binding in the brain and pituitary of adult adrenalectomized male rats.	Corticosterone	66-80	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	99-101
19368803-6	2009	We found that the dose-dependent effects of corticosterone on nuclear GR and GR-DNA binding are similar across all the areas we analyzed, although at lower levels of corticosterone changes were observed only in the hippocampus.	Corticosterone	44-58	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	70-72
19368803-6	2009	We found that the dose-dependent effects of corticosterone on nuclear GR and GR-DNA binding are similar across all the areas we analyzed, although at lower levels of corticosterone changes were observed only in the hippocampus.	Corticosterone	44-58	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	77-79
19464153-3	2009	METHOD: This study investigated both rapid and long-term expression of GR protein in the cytosolic extract, its translocation to the nucleus, and expression of mRNA for the Zif/268 gene in selected brain areas, associated with circulating levels of corticosterone, in an animal model of PTSD.	Corticosterone	249-263	early growth response 1	Rattus norvegicus	173-180
19778539-5	2009	Fos/OT neurons in the posterior parvocellular subdivision of the PVN were increased after refeeding, with a higher number in the ADX group, compared with sham and ADX+corticosterone (B) groups, with no difference in the medial parvocellular and magnocellular subdivisions of the PVN.	Corticosterone	167-181	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
19427376-4	2009	enhanced, 3h after administration, gene expression of pituitary CD14 and that of Angiotensin II AT(1A) receptors in pituitary and hypothalamic paraventricular nucleus (PVN); stimulated ACTH and corticosterone release; decreased pituitary CRF(1) receptor mRNA and increased all plasma and pituitary pro-inflammatory factors studied.	Corticosterone	194-208	CD14 molecule	Rattus norvegicus	64-68
19500777-0	2009	Mineralocorticoid receptor overexpression in basolateral amygdala reduces corticosterone secretion and anxiety.	Corticosterone	74-88	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	0-26
19589863-0	2009	Dissociation between rat hippocampal CA1 and dentate gyrus cells in their response to corticosterone: effects on calcium channel protein and current.	Corticosterone	86-100	carbonic anhydrase 1	Rattus norvegicus	37-40
19589863-6	2009	At the protein level, however, beta4 and Ca(v)1.2 levels were significantly up-regulated by corticosterone in the CA1 but not the DG area.	Corticosterone	92-106	carbonic anhydrase 1	Rattus norvegicus	114-117
19427376-4	2009	enhanced, 3h after administration, gene expression of pituitary CD14 and that of Angiotensin II AT(1A) receptors in pituitary and hypothalamic paraventricular nucleus (PVN); stimulated ACTH and corticosterone release; decreased pituitary CRF(1) receptor mRNA and increased all plasma and pituitary pro-inflammatory factors studied.	Corticosterone	194-208	angiotensin II receptor, type 1a	Rattus norvegicus	96-101
19893132-2	2009	Especially, we elucidate if Nadolol injected prior to CRH ICV has some effect on plasma corticosterone level.	Corticosterone	88-102	corticotropin releasing hormone	Rattus norvegicus	54-57
19632235-7	2009	While low levels of neonatal corticosterone improved adult cognitive abilities and increased na-Abs levels directed to SERT, high doses of neonatal corticosterone reduced hippocampal BDNF levels and na-Abs directed to DAT.	Corticosterone	29-43	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	119-123
19235128-1	2009	The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the interconversion between inactive 11-ketoglucocorticoids and their active 11beta-hydroxy derivatives, such as cortisol and corticosterone.	Corticosterone	204-218	RNA, U1 small nuclear 1	Homo sapiens	11-66
19699326-8	2009	The immunosuppressive effects on IL-1beta and IL-6 production and on TLR expression by stressed mice might have occurred due to a higher corticosterone production during stress.	Corticosterone	137-151	interleukin 1 beta	Mus musculus	33-41
19699326-8	2009	The immunosuppressive effects on IL-1beta and IL-6 production and on TLR expression by stressed mice might have occurred due to a higher corticosterone production during stress.	Corticosterone	137-151	interleukin 6	Mus musculus	46-50
19405150-5	2009	Plasma corticosterone levels during 2-hr stress sessions increased in AC5(-/-) mice compared with those of AC5(+/+) mice.	Corticosterone	7-21	adenylate cyclase 5	Mus musculus	70-73
19686449-3	2009	In the parvocellular division of the PVN (paPVN) and SON, FosB/DeltaFosB-immunoreactivity (ir) increased significantly following sham-ADX compared to naive rats, which was suppressed with either corticosterone (CORT) or dexamethasone (DEX).	Corticosterone	195-209	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
19686449-3	2009	In the parvocellular division of the PVN (paPVN) and SON, FosB/DeltaFosB-immunoreactivity (ir) increased significantly following sham-ADX compared to naive rats, which was suppressed with either corticosterone (CORT) or dexamethasone (DEX).	Corticosterone	211-215	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-62
19686449-4	2009	Following ADX, the increase in FosB/DeltaFosB-ir was much more prominent than that in the sham-ADX group, and the ADX-induced robust increase was suppressed by CORT or DEX, but not by aldosterone.	Corticosterone	160-164	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-35
19545626-0	2009	Oleoyl-estrone affects lipid metabolism in adrenalectomized rats treated with corticosterone through modulation of SREBP1c expression.	Corticosterone	78-92	sterol regulatory element binding transcription factor 1	Rattus norvegicus	115-122
19545626-8	2009	Our results confirm that corticosterone blocks - and even reverses - OE effects on body lipids in a dose-dependent way, a process mediated, at least in part, by modulation of SREBP1c expression.	Corticosterone	25-39	sterol regulatory element binding transcription factor 1	Rattus norvegicus	175-182
19631743-0	2009	Direct effects of corticosterone on ATP production by mitochondria from immortalized hypothalamic GT1-7 neurons.	Corticosterone	18-32	retinoic acid induced 1	Mus musculus	98-101
19631743-9	2009	To examine the effects of corticosterone on GT1-7 cell physiology, we incubated GT1-7 cells with t-butyl hydroperoxide (t-BuOOH) with corticosterone.	Corticosterone	134-148	retinoic acid induced 1	Mus musculus	80-83
19762876-0	2009	Calcitonin directly increases adrenocorticotropic hormone-stimulated corticosterone production in the hen adrenal gland.	Corticosterone	69-83	calcitonin	Gallus gallus	0-10
19762876-4	2009	When the cortical cells were incubated in vitro with chicken ACTH in the presence of CT, greater corticosterone production was observed.	Corticosterone	97-111	calcitonin	Gallus gallus	62-64
19762876-5	2009	The result suggested that CT acts directly on the adrenocortical cells via its receptor binding and increases responsiveness of ACTH on corticosterone production in the laying hen.	Corticosterone	136-150	calcitonin	Gallus gallus	26-28
19635548-9	2009	In parallel, corticosterone caused significant elevations in DNA fragmentation, [Ca(2+)]i concentration and caspase-3 activity.	Corticosterone	13-27	caspase 3	Rattus norvegicus	108-117
19494170-8	2009	Plasma corticosterone and aldosterone concentrations were significantly enhanced in apc(Min/+) mice.	Corticosterone	7-21	APC, WNT signaling pathway regulator	Mus musculus	84-87
19406942-3	2009	High ACTH concentrations caused by ADX in wild-type mice down-regulated CYP11B1 mRNA expression, encoding the last enzyme required for corticosterone synthesis and as a consequence reduced GC synthesis in thymocytes.	Corticosterone	135-149	pro-opiomelanocortin-alpha	Mus musculus	5-9
19406942-3	2009	High ACTH concentrations caused by ADX in wild-type mice down-regulated CYP11B1 mRNA expression, encoding the last enzyme required for corticosterone synthesis and as a consequence reduced GC synthesis in thymocytes.	Corticosterone	135-149	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	72-79
19041230-7	2009	In the testicular mitochondrial- and microsomal-rich fractions, corticosterone administration increased the levels of lipid peroxidation and hydrogen peroxide and decreased the activities of antioxidant enzymes like superoxide dismutase and catalase significantly.	Corticosterone	64-78	catalase	Rattus norvegicus	241-249
19041230-9	2009	The levels of lipid peroxidation and hydrogen peroxide increased and the activities of superoxide dismutase and catalase were decreased significantly in mitochondrial- and microsomal fractions of the testis of treated rats as compared to those treated with corticosterone alone.	Corticosterone	257-271	catalase	Rattus norvegicus	112-120
19235231-0	2009	Corticosterone reduces dendritic complexity in developing hippocampal CA1 neurons.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	70-73
19235231-10	2009	These results suggest that high physiological levels of corticosterone, via activation of the glucocorticoid receptor, can, during the course of only a few hours, reduce the dendritic complexity of CA1 pyramidal neurons in young, developing hippocampal tissue.	Corticosterone	56-70	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	94-117
19235231-10	2009	These results suggest that high physiological levels of corticosterone, via activation of the glucocorticoid receptor, can, during the course of only a few hours, reduce the dendritic complexity of CA1 pyramidal neurons in young, developing hippocampal tissue.	Corticosterone	56-70	carbonic anhydrase 1	Rattus norvegicus	198-201
19591833-1	2009	In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone.	Corticosterone	54-68	serpin family A member 6	Homo sapiens	10-41
19591833-1	2009	In birds, corticosteroid-binding globulin (CBG) binds corticosterone, progesterone and testosterone.	Corticosterone	54-68	serpin family A member 6	Homo sapiens	43-46
19591833-3	2009	Thus, an increase in corticosterone or progesterone may displace testosterone bound to CBG, leading to an increase in bioactive free testosterone levels without affecting total testosterone levels in the circulation.	Corticosterone	21-35	serpin family A member 6	Homo sapiens	87-90
19591833-12	2009	We predict that CBG occupancy by corticosterone will increase slightly following an aggressive encounter.	Corticosterone	33-47	serpin family A member 6	Homo sapiens	16-19
19632235-7	2009	While low levels of neonatal corticosterone improved adult cognitive abilities and increased na-Abs levels directed to SERT, high doses of neonatal corticosterone reduced hippocampal BDNF levels and na-Abs directed to DAT.	Corticosterone	148-162	brain derived neurotrophic factor	Mus musculus	183-187
19632235-7	2009	While low levels of neonatal corticosterone improved adult cognitive abilities and increased na-Abs levels directed to SERT, high doses of neonatal corticosterone reduced hippocampal BDNF levels and na-Abs directed to DAT.	Corticosterone	148-162	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	218-221
19484722-1	2009	In this study, we have examined the role of corticosterone (CORT) in the regulation of neuronal glutamate release using nerve terminals (synaptosomes) isolated from the rat hippocampus.	Corticosterone	44-58	cortistatin	Rattus norvegicus	60-64
19545278-5	2009	We found an increased phosphorylation of CREB (pCREB) selectively within tyrosine hydroxylase (TH) immunoreactive neurons in the NTS from morphine-withdrawn rats, which parallel elevated corticosterone levels.	Corticosterone	187-201	cAMP responsive element binding protein 1	Rattus norvegicus	41-45
19545278-5	2009	We found an increased phosphorylation of CREB (pCREB) selectively within tyrosine hydroxylase (TH) immunoreactive neurons in the NTS from morphine-withdrawn rats, which parallel elevated corticosterone levels.	Corticosterone	187-201	tyrosine hydroxylase	Rattus norvegicus	73-93
19545278-5	2009	We found an increased phosphorylation of CREB (pCREB) selectively within tyrosine hydroxylase (TH) immunoreactive neurons in the NTS from morphine-withdrawn rats, which parallel elevated corticosterone levels.	Corticosterone	187-201	tyrosine hydroxylase	Rattus norvegicus	95-97
19545278-8	2009	In contrast, PKC inhibitor calphostin C reduced the withdrawal-triggered rise in pCREB, pERK(1/2), TH expression and corticosterone secretion.	Corticosterone	117-131	protein kinase C, gamma	Rattus norvegicus	13-16
19204724-0	2009	SK2 potassium channel overexpression in basolateral amygdala reduces anxiety, stress-induced corticosterone secretion and dendritic arborization.	Corticosterone	93-107	sphingosine kinase 2	Homo sapiens	0-3
19204724-8	2009	We report that SK2 overexpression reduced anxiety and stress-induced corticosterone secretion at a systemic level.	Corticosterone	69-83	sphingosine kinase 2	Homo sapiens	15-18
19006006-4	2009	Expression levels of interleukin (IL)-1beta, IL-6, IL-18 and transforming growth factor (TGF)-beta4 mRNA were significantly up-regulated in lymphocytes 3 h after first treatment with corticosterone.	Corticosterone	183-197	interleukin 1, beta	Gallus gallus	21-43
19006006-4	2009	Expression levels of interleukin (IL)-1beta, IL-6, IL-18 and transforming growth factor (TGF)-beta4 mRNA were significantly up-regulated in lymphocytes 3 h after first treatment with corticosterone.	Corticosterone	183-197	interleukin 6	Gallus gallus	45-49
19006006-4	2009	Expression levels of interleukin (IL)-1beta, IL-6, IL-18 and transforming growth factor (TGF)-beta4 mRNA were significantly up-regulated in lymphocytes 3 h after first treatment with corticosterone.	Corticosterone	183-197	interleukin 18	Gallus gallus	51-56
19006006-4	2009	Expression levels of interleukin (IL)-1beta, IL-6, IL-18 and transforming growth factor (TGF)-beta4 mRNA were significantly up-regulated in lymphocytes 3 h after first treatment with corticosterone.	Corticosterone	183-197	transforming growth factor beta 1	Gallus gallus	61-99
19006006-6	2009	Compared with controls, corticosterone-treated birds showed greater expression levels of chemokine (CC) mRNA, particularly for CCLi2, CCL5 (RANTES), CCL16 and CXCLi1, in peripheral and splenic lymphocytes 3 h post-initial exposure.	Corticosterone	24-38	C-C motif chemokine ligand	Gallus gallus	134-138
19006006-9	2009	There was a positive correlation between plasma corticosterone concentrations and CCL5 and CCL16 mRNA at 3 h post-initial administration.	Corticosterone	48-62	C-C motif chemokine ligand	Gallus gallus	82-86
19006006-10	2009	At 1 week post-initial treatment, corticosterone concentrations correlated positively with CCL5 and negatively with IL-18 mRNA level.	Corticosterone	34-48	C-C motif chemokine ligand	Gallus gallus	91-95
19006006-10	2009	At 1 week post-initial treatment, corticosterone concentrations correlated positively with CCL5 and negatively with IL-18 mRNA level.	Corticosterone	34-48	interleukin 18	Gallus gallus	116-121
19477232-0	2009	Repeated exposure to corticosterone, but not restraint, decreases the number of reelin-positive cells in the adult rat hippocampus.	Corticosterone	21-35	reelin	Rattus norvegicus	80-86
19477232-4	2009	Given this association between reelin and hippocampal plasticity, we investigated whether repeated exposure to corticosterone or physical restraint might decrease reelin expression in specific hippocampal regions.	Corticosterone	111-125	reelin	Rattus norvegicus	163-169
19477232-6	2009	Our results revealed a significant decrease in the number of reelin-positive cells in the CA1 stratum lacunosum and the subgranular zone of the dentate gyrus in rats that received corticosterone, but not in rats that received restraint.	Corticosterone	180-194	reelin	Rattus norvegicus	61-67
19477232-6	2009	Our results revealed a significant decrease in the number of reelin-positive cells in the CA1 stratum lacunosum and the subgranular zone of the dentate gyrus in rats that received corticosterone, but not in rats that received restraint.	Corticosterone	180-194	carbonic anhydrase 1	Rattus norvegicus	90-93
19460425-9	2009	Furthermore, in males and females, the c-Fos response of npEW-Ucn1 neurons upon restraint stress was blunted in animals with MS history, a phenomenon that was concomitant with dampening of the HPA corticosterone response in females but not in males.	Corticosterone	197-211	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
19765385-5	2009	Shh is a crucial regulator of brain development and neural stem/progenitor cells, and GCs suppress Shh-induced proliferation of cerebellar progenitor cells ; Shh acts through the induction of the enzyme 11betaHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone.	Corticosterone	241-255	sonic hedgehog signaling molecule	Homo sapiens	0-3
19765385-5	2009	Shh is a crucial regulator of brain development and neural stem/progenitor cells, and GCs suppress Shh-induced proliferation of cerebellar progenitor cells ; Shh acts through the induction of the enzyme 11betaHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone.	Corticosterone	241-255	sonic hedgehog signaling molecule	Homo sapiens	99-102
19765385-5	2009	Shh is a crucial regulator of brain development and neural stem/progenitor cells, and GCs suppress Shh-induced proliferation of cerebellar progenitor cells ; Shh acts through the induction of the enzyme 11betaHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone.	Corticosterone	241-255	sonic hedgehog signaling molecule	Homo sapiens	99-102
19765385-5	2009	Shh is a crucial regulator of brain development and neural stem/progenitor cells, and GCs suppress Shh-induced proliferation of cerebellar progenitor cells ; Shh acts through the induction of the enzyme 11betaHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone.	Corticosterone	241-255	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	203-213
19435783-0	2009	Five amino acids in the innermost cavity of the substrate binding cleft of organic cation transporter 1 interact with extracellular and intracellular corticosterone.	Corticosterone	150-164	solute carrier family 22 member 1	Rattus norvegicus	75-103
19447109-1	2009	The stress hormone corticosterone acts via two receptor types in the brain: the mineralocorticoid (MR) and the glucocorticoid receptor (GR).	Corticosterone	19-33	nuclear receptor subfamily 3, group C, member 1	Mus musculus	111-134
19447109-1	2009	The stress hormone corticosterone acts via two receptor types in the brain: the mineralocorticoid (MR) and the glucocorticoid receptor (GR).	Corticosterone	19-33	nuclear receptor subfamily 3, group C, member 1	Mus musculus	136-138
19416745-0	2009	Expression of prepro-ghrelin and related receptor genes in the rat adrenal gland and evidences that ghrelin exerts a potent stimulating effect on corticosterone secretion by cultured rat adrenocortical cells.	Corticosterone	146-160	ghrelin and obestatin prepropeptide	Rattus norvegicus	100-107
19416745-8	2009	Prolonged exposure of cultured cells to GHREL resulted in a potent, comparable to ACTH, stimulating effect of GHREL on corticosterone secretion.	Corticosterone	119-133	ghrelin and obestatin prepropeptide	Rattus norvegicus	40-45
19416745-8	2009	Prolonged exposure of cultured cells to GHREL resulted in a potent, comparable to ACTH, stimulating effect of GHREL on corticosterone secretion.	Corticosterone	119-133	ghrelin and obestatin prepropeptide	Rattus norvegicus	110-115
19416745-13	2009	Thus, our study is the first to demonstrate direct stimulating effect of GHREL on corticosterone output by cultured rat adrenocortical cells.	Corticosterone	82-96	ghrelin and obestatin prepropeptide	Rattus norvegicus	73-78
19435783-1	2009	We have shown previously that Leu447 and Gln448 in the transmembrane helix (TMH) 10 of rat organic cation transporter rOCT1 are critical for inhibition of cation uptake by corticosterone.	Corticosterone	172-186	solute carrier family 22 member 1	Rattus norvegicus	118-123
19435783-3	2009	The affinity of corticosterone was determined by measuring the inhibition of currents induced by tetraethylammonium(+) (TEA(+)) in Xenopus laevis oocytes expressing rOCT1.	Corticosterone	16-30	solute carrier family 22 member 1	Rattus norvegicus	165-170
19435783-6	2009	Modeling of the interaction of corticosterone with rOCT1 in the inward- or outward-facing conformation predicted direct binding to Leu447, Phe160 (TMH2), Trp218 (TMH4), Arg440 (TMH10), and Asp475 (TM11) from both sides.	Corticosterone	31-45	solute carrier family 22 member 1	Rattus norvegicus	51-56
19630968-6	2009	After three weeks of treatment the expression of CGRP in the superficial dorsal horn was significantly decreased in both CORT and DEX groups, while GABAB2 was significantly increased; the levels of SP for both experimental groups remained unchanged at this point.	Corticosterone	121-125	calcitonin-related polypeptide alpha	Rattus norvegicus	49-53
19481553-11	2009	SIGNIFICANCE: These data show that PRL plays an important role in the regulation of corticosterone and progesterone release in LAA but not in HAA during stress.	Corticosterone	84-98	prolactin	Rattus norvegicus	35-38
19379741-9	2009	An effect of GR activation on 5-HT2A receptor levels was further corroborated by the culture studies as long-term exposure of 3 microM corticosterone to organotypic hippocampal cultures increased 5-HT2A receptor levels (p &lt; 0.05).	Corticosterone	135-149	nuclear receptor subfamily 3, group C, member 1	Mus musculus	13-15
19928051-2	2009	Protectin was found to normalize the content of corticosterone and adrenalin in adrenal glands and blood after its intranasal administration to rats one day before a cold or heat shock, or hypobaric hypoxia at doses of 1-10 microg/animal and after its intravenous administration just after acute hemorrhage at doses of 0.5-2 microg/animal.	Corticosterone	48-62	CD59 molecule	Rattus norvegicus	0-9
19283469-2	2009	We investigated the hypothesis that acute, chronic, or combined stress alters copper-zinc superoxide dismutase (CuZnSOD) expression pattern at both, mRNA and subcellular protein level in the cerebral cortex and hippocampus of rats and that there may be a relationship between stress-induced corticosterone and CuZnSOD expression.	Corticosterone	291-305	superoxide dismutase 1	Rattus norvegicus	112-119
19721888-2	2009	In a recent study, we found that GRs form a complex with B-cell lymphoma 2 (Bcl-2), trans- locate to mitochondria in response to corticosterone (CORT), and modulate mitochondrial calcium and oxidation in an inverted U-shaped manner.	Corticosterone	129-143	BCL2 apoptosis regulator	Homo sapiens	76-81
19721888-2	2009	In a recent study, we found that GRs form a complex with B-cell lymphoma 2 (Bcl-2), trans- locate to mitochondria in response to corticosterone (CORT), and modulate mitochondrial calcium and oxidation in an inverted U-shaped manner.	Corticosterone	145-149	BCL2 apoptosis regulator	Homo sapiens	57-74
19721888-2	2009	In a recent study, we found that GRs form a complex with B-cell lymphoma 2 (Bcl-2), trans- locate to mitochondria in response to corticosterone (CORT), and modulate mitochondrial calcium and oxidation in an inverted U-shaped manner.	Corticosterone	145-149	BCL2 apoptosis regulator	Homo sapiens	76-81
19179436-3	2009	This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis in adrenalectomized (ADX) rats supplemented with low CORT pellet (ADX plus CORT).	Corticosterone	61-75	tyrosine hydroxylase	Rattus norvegicus	108-128
19179436-3	2009	This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis in adrenalectomized (ADX) rats supplemented with low CORT pellet (ADX plus CORT).	Corticosterone	61-75	tyrosine hydroxylase	Rattus norvegicus	130-132
19179436-3	2009	This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis in adrenalectomized (ADX) rats supplemented with low CORT pellet (ADX plus CORT).	Corticosterone	77-81	tyrosine hydroxylase	Rattus norvegicus	108-128
19179436-3	2009	This study addressed the role of morphine withdrawal-induced corticosterone (CORT) release in regulation of tyrosine hydroxylase (TH), the rate-limiting enzyme of catecholamine biosynthesis in adrenalectomized (ADX) rats supplemented with low CORT pellet (ADX plus CORT).	Corticosterone	77-81	tyrosine hydroxylase	Rattus norvegicus	130-132
19379741-9	2009	An effect of GR activation on 5-HT2A receptor levels was further corroborated by the culture studies as long-term exposure of 3 microM corticosterone to organotypic hippocampal cultures increased 5-HT2A receptor levels (p &lt; 0.05).	Corticosterone	135-149	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	30-45
19379741-9	2009	An effect of GR activation on 5-HT2A receptor levels was further corroborated by the culture studies as long-term exposure of 3 microM corticosterone to organotypic hippocampal cultures increased 5-HT2A receptor levels (p &lt; 0.05).	Corticosterone	135-149	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	196-211
19379741-10	2009	The corticosterone-induced 5-HT2A receptor up-regulation was blocked by addition of either spironolactone or mifepristone.	Corticosterone	4-18	5-hydroxytryptamine (serotonin) receptor 2A	Mus musculus	27-42
19380458-3	2009	The key to the intracellular activation of glucocorticoid in adipocytes is 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which catalyses the production of active glucocorticoids (cortisol in humans and corticosterone in rodents) from inactive 11-keto steroids (cortisone in humans and 11-dehydrocorticosterone in rodents).	Corticosterone	214-228	RNA, U1 small nuclear 1	Homo sapiens	75-130
19229593-9	2009	Western blot analyses also depicted that the decrease and/or increase, respectively, of ADA activity by corticosterone and Bt(2)-cAMP was at the ADA protein level.	Corticosterone	104-118	adenosine deaminase	Gallus gallus	88-91
19229593-9	2009	Western blot analyses also depicted that the decrease and/or increase, respectively, of ADA activity by corticosterone and Bt(2)-cAMP was at the ADA protein level.	Corticosterone	104-118	adenosine deaminase	Gallus gallus	145-148
19409434-5	2009	Chicken ghrelin administration induced a significant short-term (&lt;30 min) reduction in food intake and markedly elevated plasma corticosterone levels.	Corticosterone	131-145	ghrelin/obestatin prepropeptide	Gallus gallus	8-15
19815953-8	2009	Finally, we showed that LF induced a rise in the serum levels of corticosterone in control but not adrenalectomized mice.We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis.	Corticosterone	65-79	lactotransferrin	Mus musculus	24-26
19815953-8	2009	Finally, we showed that LF induced a rise in the serum levels of corticosterone in control but not adrenalectomized mice.We conclude that LF-induced upregulation of endogenous steroid levels is responsible for the stimulation of myelopoiesis.	Corticosterone	65-79	lactotransferrin	Mus musculus	138-140
19181453-2	2009	Brain-derived neurotrophic factor (BDNF) has been implicated in the neurobiological mechanisms of these changes, in interaction with components of the stress response, such as corticosterone.	Corticosterone	176-190	brain-derived neurotrophic factor	Rattus norvegicus	0-33
19181453-2	2009	Brain-derived neurotrophic factor (BDNF) has been implicated in the neurobiological mechanisms of these changes, in interaction with components of the stress response, such as corticosterone.	Corticosterone	176-190	brain-derived neurotrophic factor	Rattus norvegicus	35-39
19361536-10	2009	Both sexes of ADAR2 transgenic mice displayed elevated plasma corticosterone.	Corticosterone	62-76	adenosine deaminase, RNA-specific, B1	Mus musculus	14-19
19429162-2	2009	The rhythmic release of corticosterone has been shown in rats to be necessary for the rhythmic expression of the clock protein PERIOD2 (PER2) in select regions of the limbic forebrain.	Corticosterone	24-38	clock circadian regulator	Rattus norvegicus	113-118
19429162-2	2009	The rhythmic release of corticosterone has been shown in rats to be necessary for the rhythmic expression of the clock protein PERIOD2 (PER2) in select regions of the limbic forebrain.	Corticosterone	24-38	period circadian regulator 2	Rattus norvegicus	127-134
19429162-2	2009	The rhythmic release of corticosterone has been shown in rats to be necessary for the rhythmic expression of the clock protein PERIOD2 (PER2) in select regions of the limbic forebrain.	Corticosterone	24-38	period circadian regulator 2	Rattus norvegicus	136-140
19429162-6	2009	These results implicate brain GR receptors in the regulation of PER2 expression in the BNSTov and CEA and are consistent with our previous findings that the rhythmic expression of PER2 in these areas is selectively sensitive to fluctuations in circulating corticosterone.	Corticosterone	256-270	period circadian clock 2	Mus musculus	180-184
19494313-4	2009	The effects of corticosterone were assessed on cytokine profile and glucocorticoid receptor activation in LPS-stimulated spleen cell cultures in vitro.	Corticosterone	15-29	nuclear receptor subfamily 3, group C, member 1	Mus musculus	68-91
19272414-9	2009	The bidirectional effect of galanin was correlated with changes in stress hormone levels (adrenocorticotropic hormone and corticosterone).	Corticosterone	122-136	galanin and GMAP prepropeptide	Mus musculus	28-35
19401166-6	2009	Our results showed that 18-day and 36-day corticosterone injections caused increased depression-like behavior in male mice and significantly reduced the NF-L protein levels in the hippocampal tissues.	Corticosterone	42-56	neurofilament, light polypeptide	Mus musculus	153-157
19229593-10	2009	In conclusion, the study suggests that the ADA activity level is highest at day 1 in all the regions of chicken GIT and could be reduced or enhanced by corticosterone and dibutyryl cAMP, respectively, in an age-specific manner.	Corticosterone	152-166	adenosine deaminase	Gallus gallus	43-46
19362542-5	2009	Although corticosterone (CORT) levels temporally coincided with the increasing phase of apoE in the hypothalamus in both FF and RF rats, depletion of CORT by adrenalectomy (ADX) did not significantly influence the hypothalamic apoE levels during either period, implying that the circadian pattern of hypothalamic apoE is regulated by factors other than circulating CORT.	Corticosterone	9-23	cortistatin	Rattus norvegicus	25-29
19362542-5	2009	Although corticosterone (CORT) levels temporally coincided with the increasing phase of apoE in the hypothalamus in both FF and RF rats, depletion of CORT by adrenalectomy (ADX) did not significantly influence the hypothalamic apoE levels during either period, implying that the circadian pattern of hypothalamic apoE is regulated by factors other than circulating CORT.	Corticosterone	9-23	apolipoprotein E	Rattus norvegicus	88-92
19213843-5	2009	Conditional knockout mice with a deletion of the GR at the pituitary (GR(POMCCre)) show excessive basal corticosterone levels during postnatal development, but not in adulthood.	Corticosterone	104-118	nuclear receptor subfamily 3, group C, member 1	Mus musculus	49-51
19213843-5	2009	Conditional knockout mice with a deletion of the GR at the pituitary (GR(POMCCre)) show excessive basal corticosterone levels during postnatal development, but not in adulthood.	Corticosterone	104-118	nuclear receptor subfamily 3, group C, member 1	Mus musculus	70-72
19246538-0	2009	Vasopressin administration into the paraventricular nucleus normalizes plasma oxytocin and corticosterone levels in Brattleboro rats.	Corticosterone	91-105	arginine vasopressin	Rattus norvegicus	0-11
19246538-9	2009	Thus, endogenous vasopressin released within the PVN is likely to act as a paracrine signal to facilitate the return of plasma oxytocin and corticosterone to basal levels after acute stressor exposure.	Corticosterone	140-154	arginine vasopressin	Rattus norvegicus	17-28
19442036-4	2009	These receptors directly (GH) or indirectly (CRH --&gt; ACTH --&gt; corticosterone; TRH --&gt; TSH --&gt; T(3)) stimulate the secretion of hormones, which activate nuclear/cytosolic receptors controlling CYP genes.	Corticosterone	68-82	corticotropin releasing hormone	Rattus norvegicus	45-48
19371745-2	2009	In vertebrates, DMH serotonin (5-HT) concentrations increase rapidly in response to acute stressors or corticosterone (CORT).	Corticosterone	103-117	cortistatin	Rattus norvegicus	119-123
19179307-6	2009	Adrenal cholesterol levels and plasma corticosterone levels were 38-52% decreased in SR-BI KO mice with and without CETP expression.	Corticosterone	38-52	scavenger receptor class B, member 1	Mus musculus	85-90
19357347-6	2009	The role of corticosterone (CORT) in the observed plasticity was confirmed, because exogenous administration of 10 mg/kg CORT also enhanced AMPAR/NMDAR ratios in the NAc shell.	Corticosterone	12-26	cortistatin	Homo sapiens	28-32
19357347-6	2009	The role of corticosterone (CORT) in the observed plasticity was confirmed, because exogenous administration of 10 mg/kg CORT also enhanced AMPAR/NMDAR ratios in the NAc shell.	Corticosterone	12-26	cortistatin	Homo sapiens	121-125
19457551-1	2009	The effects of subcutaneous Nociceptin/Orphanin FQ (N/OFQ) administration on corticosterone (CORT) secretion were determined in male and female wild-type mice and mice lacking the N/OFQ prepropeptide.	Corticosterone	77-91	prepronociceptin	Mus musculus	52-57
19409113-3	2009	On the other hand, it can be directly inhibited by excessive glucocorticoid (Corticosterone, CORT, in rats) which is beyond the protective capability of 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and type 2 (11beta-HSD2; encoded by gene Hsd11b2 in rats) in Leydig cells.	Corticosterone	77-91	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	222-233
19409113-3	2009	On the other hand, it can be directly inhibited by excessive glucocorticoid (Corticosterone, CORT, in rats) which is beyond the protective capability of 11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) and type 2 (11beta-HSD2; encoded by gene Hsd11b2 in rats) in Leydig cells.	Corticosterone	77-91	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	251-258
19217938-7	2009	Addition of exogenous IL-12 to LPS-stimulated spleen cells reversed the suppressive effect of both restraint stress and corticosterone on IFN-gamma production.	Corticosterone	120-134	interferon gamma	Mus musculus	138-147
18990085-2	2009	Endogenous corticosterone, in the presence of the 11betaHSD2 (11beta hydroxysteroid dehydrogenase type 2) inhibitor CBX (carbenoxolone) plus salt, produces similar inflammatory responses and tissue remodelling via activation of MR. MR-mediated oxidative stress has previously been suggested to account for these responses.	Corticosterone	11-25	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	50-60
18990085-2	2009	Endogenous corticosterone, in the presence of the 11betaHSD2 (11beta hydroxysteroid dehydrogenase type 2) inhibitor CBX (carbenoxolone) plus salt, produces similar inflammatory responses and tissue remodelling via activation of MR. MR-mediated oxidative stress has previously been suggested to account for these responses.	Corticosterone	11-25	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	62-104
18990085-3	2009	In the present study we thus postulated that when 11betaHSD2 is inhibited, endogenous corticosterone bound to unprotected MR in the vessel wall may similarly increase early biomarkers of oxidative stress.	Corticosterone	86-100	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	50-60
18990085-9	2009	The findings of the present study support the hypothesis that endogenous corticosterone in the presence of CBX can activate vascular MR to produce both inflammatory and oxidative tissue responses well before the onset of fibrosis, that the two MR ligands induce differential but overlapping patterns of gene expression, and that elevation of NOX2 subunit levels does not appear necessary for full expression of MR-mediated inflammatory and fibrogenic responses.	Corticosterone	73-87	cytochrome b-245 beta chain	Rattus norvegicus	342-346
19157766-0	2009	Somatotropin response in vitro to corticosterone and triiodothyronine during chick embryonic development: Involvement of type I and type II glucocorticoid receptors.	Corticosterone	34-48	growth hormone	Gallus gallus	0-12
19157766-1	2009	Corticosterone (CORT) can stimulate growth hormone (GH) secretion on embryonic day (e) 12 in the chicken.	Corticosterone	0-14	CORT	Gallus gallus	16-20
19157766-1	2009	Corticosterone (CORT) can stimulate growth hormone (GH) secretion on embryonic day (e) 12 in the chicken.	Corticosterone	0-14	growth hormone	Gallus gallus	36-50
19157766-1	2009	Corticosterone (CORT) can stimulate growth hormone (GH) secretion on embryonic day (e) 12 in the chicken.	Corticosterone	0-14	growth hormone	Gallus gallus	52-54
19157766-7	2009	Corticosterone significantly increased GH mRNA and protein secretion on e12; however, mRNA concentration and protein secretion were unaffected on e20.	Corticosterone	0-14	growth hormone	Gallus gallus	39-41
19349910-4	2009	RESULTS: In hypertrophied hearts of Dahl salt-sensitive rats and TAC mice, the gene expressions of steroidogenic acute regulatory protein and CYP11A, rate limiting factors of steroid biosynthesis, were significantly upregulated and cardiac corticosterone level was increased compared with age-matched control.	Corticosterone	240-254	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	142-148
19411541-3	2009	By contrast, the quantification of corticosterone (CORT) in feathers represents a long-term, integrated measure of hypothalamic-pituitary-adrenal activity.	Corticosterone	35-49	cortistatin	Homo sapiens	51-55
19297425-0	2009	Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.	Corticosterone	9-23	CREB regulated transcription coactivator 1	Mus musculus	110-116
19297425-0	2009	Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1.	Corticosterone	9-23	DNA-damage-inducible transcript 4	Rattus norvegicus	128-133
19297425-9	2009	In contrast, serum corticosterone levels correlated directly with REDD1 mRNA expression (r = 0.68; P = 0.01).	Corticosterone	19-33	DNA-damage-inducible transcript 4	Rattus norvegicus	66-71
19297425-10	2009	Moreover, inhibiting corticosterone-mediated signaling via administration of the glucocorticoid receptor antagonist RU486 blocked both the food deprivation- and diabetes-induced increase in REDD1 mRNA expression.	Corticosterone	21-35	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	81-104
19297425-10	2009	Moreover, inhibiting corticosterone-mediated signaling via administration of the glucocorticoid receptor antagonist RU486 blocked both the food deprivation- and diabetes-induced increase in REDD1 mRNA expression.	Corticosterone	21-35	DNA-damage-inducible transcript 4	Rattus norvegicus	190-195
19302190-6	2009	In the periventricular area of the hypothalamus, we observed a marked decrease in thyrotrophin-releasing hormone (TRH) mRNA expression in TRbeta(-/-) and WT mice at t = 4 h, coinciding with the peak in plasma corticosterone.	Corticosterone	209-223	thyrotropin releasing hormone	Mus musculus	82-112
19302190-6	2009	In the periventricular area of the hypothalamus, we observed a marked decrease in thyrotrophin-releasing hormone (TRH) mRNA expression in TRbeta(-/-) and WT mice at t = 4 h, coinciding with the peak in plasma corticosterone.	Corticosterone	209-223	thyrotropin releasing hormone	Mus musculus	114-117
19302190-6	2009	In the periventricular area of the hypothalamus, we observed a marked decrease in thyrotrophin-releasing hormone (TRH) mRNA expression in TRbeta(-/-) and WT mice at t = 4 h, coinciding with the peak in plasma corticosterone.	Corticosterone	209-223	thyroid hormone receptor beta	Mus musculus	138-144
19428772-10	2009	When compared to hemiadrenalectomized animals receiving saline, a significant decrease of blood corticosterone levels was observed after 24h in rats treated with the highest dose of NMU.	Corticosterone	96-110	neuromedin U	Rattus norvegicus	182-185
19000934-0	2009	Corticosterone suppresses insulin- and NO-stimulated muscle glucose uptake in broiler chickens (Gallus gallus domesticus).	Corticosterone	0-14	insulin	Gallus gallus	26-33
19000934-8	2009	The results indicated that the reduced circulating and muscle level of NO level via the suppression of NOS by corticosterone treatment was involved in the stress-induced insulin resistance.	Corticosterone	110-124	insulin	Gallus gallus	170-177
19000934-10	2009	We conclude that NO could stimulate glucose transport in chicken skeletal muscle and that the reduced circulating and muscle level of NO is involved in the insulin resistance induced by corticosterone treatment.	Corticosterone	186-200	insulin	Gallus gallus	156-163
19036875-5	2009	Treatment with CORT also caused a rapid and dose-dependent increase in KLF9 mRNA in X. laevis XTC-2 cells that was resistant to inhibition of protein synthesis.	Corticosterone	15-19	Kruppel-like factor 9 L homeolog	Xenopus laevis	71-75
19095740-3	2009	Mammalian studies have linked early postnatal stress to later changes in the hypothalamic-pituitary-adrenal axis; however, the physiological link [lactational corticosterone (CORT) transfer] between mother and offspring during postnatal development constrains the ability to determine the direct effects of such stressors on subsequent physiology and behavior.	Corticosterone	159-173	cortistatin	Homo sapiens	175-179
19054412-4	2009	Overall, corticosterone--with other stress hormones--rapidly enhances CA1/CA3 hippocampal activity shortly after stress.	Corticosterone	9-23	carbonic anhydrase 1	Homo sapiens	70-73
19054412-4	2009	Overall, corticosterone--with other stress hormones--rapidly enhances CA1/CA3 hippocampal activity shortly after stress.	Corticosterone	9-23	carbonic anhydrase 3	Homo sapiens	74-77
19523400-2	2009	To study the role of glucocorticoid in the expression and regulation of the VT2R, corticosterone (1 or 5mg/bird/day) or metapyrone (10 or 50mg/kg body weight/day) were administered daily for 8 days to white leghorn chickens.	Corticosterone	82-96	arginine vasopressin receptor 1B	Gallus gallus	76-80
19523400-3	2009	While low doses were ineffective, a high dose of corticosterone upregulated, while metapyrone downregulated, pituitary VT2R mRNA expression and ir-VT2 in the cephalic lobe of the anterior pituitary.	Corticosterone	49-63	arginine vasopressin receptor 1B	Gallus gallus	119-123
19523400-5	2009	In view of the classical negative feedback effect of glucocorticoids at the level of hypothalamic CRH neurons and pituitary corticotrophs, high corticosterone level-induced suppression of the CRH-ACTH axis may have been masked by VT2R-mediated stimulation of corticotrophs, and hence the POMC mRNA level did not change.	Corticosterone	144-158	corticotropin releasing hormone	Gallus gallus	98-101
19523400-5	2009	In view of the classical negative feedback effect of glucocorticoids at the level of hypothalamic CRH neurons and pituitary corticotrophs, high corticosterone level-induced suppression of the CRH-ACTH axis may have been masked by VT2R-mediated stimulation of corticotrophs, and hence the POMC mRNA level did not change.	Corticosterone	144-158	arginine vasopressin receptor 1B	Gallus gallus	230-234
19523400-5	2009	In view of the classical negative feedback effect of glucocorticoids at the level of hypothalamic CRH neurons and pituitary corticotrophs, high corticosterone level-induced suppression of the CRH-ACTH axis may have been masked by VT2R-mediated stimulation of corticotrophs, and hence the POMC mRNA level did not change.	Corticosterone	144-158	proopiomelanocortin	Gallus gallus	288-292
19059472-10	2009	The vasopressin deficiency of the mother reduced the resting ACTH and all corticosterone levels in all pups.	Corticosterone	74-88	arginine vasopressin	Rattus norvegicus	4-15
19303963-6	2009	Moreover, corticosterone reduced postoperative plasma interleukin-6, catecholamines, and glucose (all P &lt; .001-.05) without any effect on the plasma corticosterone concentration compared with vehicle-treated controls.	Corticosterone	10-24	interleukin 6	Rattus norvegicus	54-67
19303963-7	2009	A preoperative 2-hour exposure of physiologic poststress corticosterone concentrations not only suppressed plasma IL-6 levels but also inhibited surgery-induced adrenaline release and suppressed plasma glucose levels.	Corticosterone	57-71	interleukin 6	Rattus norvegicus	114-118
19148127-8	2009	Mature adipocytes respond to corticosterone regarding MCP-1 and resistin release.	Corticosterone	29-43	chemokine (C-C motif) ligand 2	Mus musculus	54-59
18980809-8	2009	Consistent with these findings, the corticosterone response to dexamethasone was blunted in SERT(/( mice relative to SERT+/+ and +/( mice.	Corticosterone	36-50	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	92-96
19401166-7	2009	However, 6-day corticosterone injection exhibited an anti-depressant effect accompanied by increased levels of MAP2 and NF-L in the hippocampus.	Corticosterone	15-29	microtubule-associated protein 2	Mus musculus	111-115
19401166-7	2009	However, 6-day corticosterone injection exhibited an anti-depressant effect accompanied by increased levels of MAP2 and NF-L in the hippocampus.	Corticosterone	15-29	neurofilament, light polypeptide	Mus musculus	120-124
19361479-5	2009	Acute stress caused comparably increased levels of corticosterone in both control (CRH-COEcon-Cam) and CRH overexpressing (CRH-COEhom-Cam) animals.	Corticosterone	51-65	corticotropin releasing hormone	Mus musculus	83-86
19361479-5	2009	Acute stress caused comparably increased levels of corticosterone in both control (CRH-COEcon-Cam) and CRH overexpressing (CRH-COEhom-Cam) animals.	Corticosterone	51-65	corticotropin releasing hormone	Mus musculus	103-106
19361479-5	2009	Acute stress caused comparably increased levels of corticosterone in both control (CRH-COEcon-Cam) and CRH overexpressing (CRH-COEhom-Cam) animals.	Corticosterone	51-65	corticotropin releasing hormone	Mus musculus	103-106
19022343-1	2009	We have previously reported that Melanocortin 2 receptor (MC2R(-/-)) deficient mice on B6 N5 generations exhibited macroscopically detectable adrenal glands with markedly atrophied zona fasciculata (zF) and lack of detectable levels of corticosterone, and reduced serum concentrations of aldosterone and epinephrine.	Corticosterone	236-250	melanocortin 2 receptor	Mus musculus	33-56
19022343-1	2009	We have previously reported that Melanocortin 2 receptor (MC2R(-/-)) deficient mice on B6 N5 generations exhibited macroscopically detectable adrenal glands with markedly atrophied zona fasciculata (zF) and lack of detectable levels of corticosterone, and reduced serum concentrations of aldosterone and epinephrine.	Corticosterone	236-250	melanocortin 2 receptor	Mus musculus	58-67
19022343-4	2009	MC2R(-/-) mice delivered from MC2R(-/-) dams failed to survive due to lung failure, suggesting that fetal or maternal corticosterone is essential for lung maturation.	Corticosterone	118-132	melanocortin 2 receptor	Mus musculus	0-4
19175364-7	2009	Western blot analysis showed that corticosterone increased ERK1/2 phosphorylation in PC12 cells and curcumin 10(-9) M to 10(-6) M significantly inhibited corticosterone-induced ERK1/2 phosphorylation in PC12 cells in a dose-dependent manner.	Corticosterone	34-48	mitogen activated protein kinase 3	Rattus norvegicus	59-65
19175364-7	2009	Western blot analysis showed that corticosterone increased ERK1/2 phosphorylation in PC12 cells and curcumin 10(-9) M to 10(-6) M significantly inhibited corticosterone-induced ERK1/2 phosphorylation in PC12 cells in a dose-dependent manner.	Corticosterone	34-48	mitogen activated protein kinase 3	Rattus norvegicus	177-183
19175364-7	2009	Western blot analysis showed that corticosterone increased ERK1/2 phosphorylation in PC12 cells and curcumin 10(-9) M to 10(-6) M significantly inhibited corticosterone-induced ERK1/2 phosphorylation in PC12 cells in a dose-dependent manner.	Corticosterone	154-168	mitogen activated protein kinase 3	Rattus norvegicus	59-65
19175364-7	2009	Western blot analysis showed that corticosterone increased ERK1/2 phosphorylation in PC12 cells and curcumin 10(-9) M to 10(-6) M significantly inhibited corticosterone-induced ERK1/2 phosphorylation in PC12 cells in a dose-dependent manner.	Corticosterone	154-168	mitogen activated protein kinase 3	Rattus norvegicus	177-183
19077175-9	2009	As CRHR1(-/-) are known to be severely impaired in stress-induced corticosterone secretion, our observation also implicates that corticosterone is dispensable for CB(1)-mediated acute fear adaptation.	Corticosterone	66-80	corticotropin releasing hormone receptor 1	Mus musculus	3-8
19207807-6	2009	Ostreogen enhances stress activated adrenocorticotrophic hormone (ACTH) and corticosterone (CORT) secretion, whereas testosterone decreases the gain of the HPA axis and inhibits ACTH and CORT responses to stress.	Corticosterone	76-90	cortistatin	Rattus norvegicus	92-96
19098165-10	2009	attenuated increases in plasma ACTH and corticosterone elicited by intracerebroventricular injection of [cPP(1-7),NPY(19-23),Ala(31),Aib(32),Gln(34)]-hPancreatic Polypeptide.	Corticosterone	40-54	neuropeptide Y	Rattus norvegicus	114-117
19365524-2	2009	They reveal an increased expression of 11beta-hydroxysteroid dehydrogenase 1 (11HSD1), which locally increases concentration of corticosterone in the liver.	Corticosterone	128-142	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	39-76
19365524-2	2009	They reveal an increased expression of 11beta-hydroxysteroid dehydrogenase 1 (11HSD1), which locally increases concentration of corticosterone in the liver.	Corticosterone	128-142	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	78-84
18850490-7	2009	A dose-dependent decrease of SOD and CAT, and increase in protein oxidation was observed between the high (40 mg/kg) and low (10 mg/kg) doses of corticosterone.	Corticosterone	145-159	catalase	Rattus norvegicus	37-40
19201904-4	2009	In this study, we demonstrate that OPN(-/-) mice are resistant to chronic restraint stress (CRS)-induced lymphoid (largely thymus) organ atrophy; additionally, the stress-induced up-regulation of corticosterone production is significantly reduced in OPN(-/-) mice.	Corticosterone	196-210	secreted phosphoprotein 1	Mus musculus	35-38
18805441-3	2009	Plasma corticosterone (CORT) levels of sleep disturbed and exercise control rats were elevated compared to cage controls, suggesting that the increased exploration observed in the sleep disturbed rats was not due to a hypothalamic-pituitary-adrenal (HPA) stress response.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
19193887-4	2009	However, mPGES-1-deficient mice showed attenuated transcriptional activation of corticotropin-releasing hormone (CRH) that was followed by attenuated plasma concentrations of adrenocorticotropic hormone and corticosterone.	Corticosterone	207-221	prostaglandin E synthase	Mus musculus	9-16
19193887-4	2009	However, mPGES-1-deficient mice showed attenuated transcriptional activation of corticotropin-releasing hormone (CRH) that was followed by attenuated plasma concentrations of adrenocorticotropic hormone and corticosterone.	Corticosterone	207-221	corticotropin releasing hormone	Mus musculus	80-111
19193887-4	2009	However, mPGES-1-deficient mice showed attenuated transcriptional activation of corticotropin-releasing hormone (CRH) that was followed by attenuated plasma concentrations of adrenocorticotropic hormone and corticosterone.	Corticosterone	207-221	corticotropin releasing hormone	Mus musculus	113-116
19193887-5	2009	Cox-2 inhibition similarly blunted the delayed corticosterone response and further attenuated corticosterone release in mPGES-1 knock-out mice.	Corticosterone	47-61	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
19193887-5	2009	Cox-2 inhibition similarly blunted the delayed corticosterone response and further attenuated corticosterone release in mPGES-1 knock-out mice.	Corticosterone	94-108	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
19193887-5	2009	Cox-2 inhibition similarly blunted the delayed corticosterone response and further attenuated corticosterone release in mPGES-1 knock-out mice.	Corticosterone	94-108	prostaglandin E synthase	Mus musculus	120-127
19025979-2	2009	OCT3-mediated transport is directly inhibited by corticosterone, suggesting a potential role for the transporter in mediating some of the effects of stress and glucocorticoids on monoaminergic neurotransmission.	Corticosterone	49-63	solute carrier family 22 member 3	Rattus norvegicus	0-4
19025979-6	2009	The widespread distribution of OCT3-ir cell bodies, including regions receiving dense monoaminergic projections, suggests an important role for this transporter in regulating extracellular concentrations of monoamines in the rat brain and is consistent with the hypothesis that corticosterone-induced inhibition of OCT3-mediated transport may contribute to effects of acute stress or corticosterone on monoaminergic neurotransmission.	Corticosterone	278-292	solute carrier family 22 member 3	Rattus norvegicus	31-35
19025979-6	2009	The widespread distribution of OCT3-ir cell bodies, including regions receiving dense monoaminergic projections, suggests an important role for this transporter in regulating extracellular concentrations of monoamines in the rat brain and is consistent with the hypothesis that corticosterone-induced inhibition of OCT3-mediated transport may contribute to effects of acute stress or corticosterone on monoaminergic neurotransmission.	Corticosterone	278-292	solute carrier family 22 member 3	Rattus norvegicus	315-319
19025979-6	2009	The widespread distribution of OCT3-ir cell bodies, including regions receiving dense monoaminergic projections, suggests an important role for this transporter in regulating extracellular concentrations of monoamines in the rat brain and is consistent with the hypothesis that corticosterone-induced inhibition of OCT3-mediated transport may contribute to effects of acute stress or corticosterone on monoaminergic neurotransmission.	Corticosterone	384-398	solute carrier family 22 member 3	Rattus norvegicus	31-35
19164857-7	2009	Importantly, 11betaHSD2 antagonized the effects of the GCs corticosterone, hydrocortisone, and prednisolone, but not the synthetic GC dexamethasone.	Corticosterone	59-73	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	13-23
19244604-3	2009	They show that GCs suppress Shh-induced proliferation of cerebellar progenitor cells in postnatal mice and that, conversely, Shh signaling is protective against GC-induced neonatal cerebellar injury by inducing the enzyme 11betaHSD2, which inactivates the GCs corticosterone and prednisolone, but not dexamethasone.	Corticosterone	260-274	sonic hedgehog	Mus musculus	125-128
18850490-4	2009	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	Corticosterone	93-107	catalase	Rattus norvegicus	254-262
18850490-4	2009	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	Corticosterone	93-107	catalase	Rattus norvegicus	264-267
18850490-4	2009	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	Corticosterone	93-107	hematopoietic prostaglandin D synthase	Rattus norvegicus	270-295
18850490-4	2009	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	Corticosterone	93-107	hematopoietic prostaglandin D synthase	Rattus norvegicus	297-300
18850490-4	2009	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	Corticosterone	93-107	glutathione-disulfide reductase	Rattus norvegicus	306-327
18850490-4	2009	The data presented here indicate a substantial decline in antioxidant defences by actions of corticosterone, evidenced by coordinate decreases in the activities in the brain, liver and heart of free-radical scavenging enzymes superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST) and glutathione reductase (GR), as well as the non-enzymatic antioxidants glutathione (GSH) and serum urate.	Corticosterone	93-107	glutathione-disulfide reductase	Rattus norvegicus	329-331
19507271-4	2009	The levels of corticosterone level in plasma and corticotropin-releasing hormone (CRH) mRNA expression in hypothalamus were also measured by enzyme-linked immunosorbent assays (ELISA) and real-time reverse transcription PCR (RT-PCR), respectively.	Corticosterone	14-28	corticotropin releasing hormone	Rattus norvegicus	82-85
19053318-7	2009	The classical uptake2 transport in rat myocardial cells was inhibited by the typical EMT inhibitor, corticosterone, and surprisingly was also inhibited by low concentrations of another drug, a well-known P-gp inhibitor, GF120918.	Corticosterone	100-114	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	204-208
19032587-7	2009	As maternal plasma corticosterone levels during PS were similar in both strains, we examined placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which catalyses rapid inactivation of maternal corticosterone to inert 11-dehydrocorticosterone and thus serves as a physiological "barrier" to maternal glucocorticoids.	Corticosterone	208-222	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	103-145
19032587-7	2009	As maternal plasma corticosterone levels during PS were similar in both strains, we examined placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which catalyses rapid inactivation of maternal corticosterone to inert 11-dehydrocorticosterone and thus serves as a physiological "barrier" to maternal glucocorticoids.	Corticosterone	208-222	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	147-158
19546095-2	2009	Additionally, concentration of corticosterone (CORT) in plasma was estimated.	Corticosterone	31-45	cortistatin	Rattus norvegicus	47-51
19094090-10	2009	Both acute and chronic stress levels of corticosterone resulted in a concomitant decrease in Kiss1 and an increase in kiss1r mRNA expression in the mPOA and ARC.	Corticosterone	40-54	KiSS-1 metastasis-suppressor	Rattus norvegicus	93-98
19094090-10	2009	Both acute and chronic stress levels of corticosterone resulted in a concomitant decrease in Kiss1 and an increase in kiss1r mRNA expression in the mPOA and ARC.	Corticosterone	40-54	KISS1 receptor	Rattus norvegicus	118-124
20411778-14	2009	Western blot analysis showed time-dependent decrease and elevation of TH and GFAP levels, respectively, in the lesioned versus contralateral midbrain sides, events potentiated by ADX and worsened by corticosterone replacement.	Corticosterone	199-213	glial fibrillary acidic protein	Rattus norvegicus	77-81
19521113-3	2009	In Wistar rats, chronic social isolation leads to a significant decrease in serum corticosterone (CORT), probably due to alterations in the GR signaling pathway.	Corticosterone	82-96	cortistatin	Rattus norvegicus	98-102
19521113-3	2009	In Wistar rats, chronic social isolation leads to a significant decrease in serum corticosterone (CORT), probably due to alterations in the GR signaling pathway.	Corticosterone	82-96	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	140-142
18380537-1	2009	Plasma corticosterone (CORT) measures are a common procedure to detect stress responses in rodents.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
19305644-4	2009	METHODOLOGY/PRINCIPAL FINDINGS: Using immunocytochemistry and live cell imaging techniques we show that corticosterone selectively increases surface expression of the AMPAR subunit GluR2 in primary hippocampal cultures via a glucocorticoid receptor and protein synthesis dependent mechanism.	Corticosterone	104-118	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	181-186
19305644-5	2009	In agreement, we report that corticosterone also dramatically increases the fraction of surface expressed GluR2 that undergo lateral diffusion.	Corticosterone	29-43	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	106-111
19305644-6	2009	Furthermore, our data indicate that corticosterone facilitates NMDAR-invoked endocytosis of both synaptic and extra-synaptic GluR2 under conditions that weaken synaptic transmission.	Corticosterone	36-50	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	125-130
19305644-7	2009	CONCLUSION/SIGNIFICANCE: Our results reveal that corticosterone increases mobile GluR2 containing AMPARs.	Corticosterone	49-63	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	81-86
19305644-7	2009	CONCLUSION/SIGNIFICANCE: Our results reveal that corticosterone increases mobile GluR2 containing AMPARs.	Corticosterone	49-63	glutamate ionotropic receptor AMPA type subunit 2	Homo sapiens	98-104
19180187-4	2009	Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6.	Corticosterone	172-186	glutamate ionotropic receptor kainate type subunit 4	Rattus norvegicus	98-101
19180187-4	2009	Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6.	Corticosterone	172-186	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	103-108
19180187-4	2009	Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6.	Corticosterone	172-186	glutamate ionotropic receptor kainate type subunit 3	Rattus norvegicus	113-118
19180187-4	2009	Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6.	Corticosterone	172-186	glutamate ionotropic receptor kainate type subunit 4	Rattus norvegicus	202-205
19180187-4	2009	Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6.	Corticosterone	172-186	glutamate ionotropic receptor kainate type subunit 3	Rattus norvegicus	210-215
19180187-4	2009	Our results show that, after 7 days, adrenalectomy results in increased expression of hippocampal KA1, GluR6 and GluR7 mRNAs, an effect which is reversed by treatment with corticosterone in the case of KA1 and GluR7 and by aldosterone treatment in the case of GluR6.	Corticosterone	172-186	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	260-265
19180187-6	2009	Similarly, 21 days of treatment with a moderate dose of corticosterone also increased KA1 mRNA in the dentate gyrus, whereas a high corticosterone dose has no effect.	Corticosterone	56-70	glutamate ionotropic receptor kainate type subunit 4	Rattus norvegicus	86-89
18609294-3	2009	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Corticosterone	125-139	prolactin	Rattus norvegicus	25-34
18609294-3	2009	Although incubation with prolactin (PRL) and/or adrenocorticotrophic hormone (ACTH) resulted in a dose-dependent increase of corticosterone and progesterone release by adrenal cells from both HAA and LAA male rats, the responses were markedly increased for adrenal cells from LAA rats as compared with HAA rats.	Corticosterone	125-139	prolactin	Rattus norvegicus	36-39
19223159-2	2009	House mice (Mus domesticus) that have been selectively bred for high voluntary wheel running exhibit chronically elevated (two-fold, on average) plasma corticosterone (CORT) levels and hence are an interesting model to study possible glucocorticoid-induced immune suppression.	Corticosterone	152-166	cortistatin	Mus musculus	168-172
18826995-5	2008	11 beta-Hydroxysteroid dehydrogenase type 1 is known to convert inactive 11-dehydrocorticosterone to active corticosterone.	Corticosterone	83-97	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-43
18826995-7	2008	Knockdown of renal medullary 11 beta-hydroxysteroid dehydrogenase type 1 with small-interfering RNA attenuated the early phase of salt-induced hypertension in Dahl salt-sensitive rats and reduced urinary excretion of corticosterone.	Corticosterone	217-231	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	29-72
19120091-7	2008	Since the PVN-projecting NPY neurons in the arcuate neurons are sensitive to alterations in circulating corticosterone levels, the existence of a possible short feedback route in the stress-activated hypothalamo-pituitary-adrenocortical system is discussed.	Corticosterone	104-118	neuropeptide Y	Rattus norvegicus	25-28
19120128-1	2008	The hypothesis that vasopressin (VP) becomes the main mediator of pituitary corticotroph responsiveness during chronic hypothalamic pituitary adrenal (HPA) axis activation was tested by examining the effect of pharmacologic VP receptor blockade on the adrenocorticotropic hormone (ACTH) and corticosterone responses of 14-day repeatedly restrained rats.	Corticosterone	291-305	arginine vasopressin	Rattus norvegicus	20-31
18368033-5	2008	The results show that glucocorticoids (dexamethasone, prednisolone, cortisol and corticosterone) caused a concentration-dependent inhibition of LPS-stimulated IL-6 levels.	Corticosterone	81-95	interleukin 6	Homo sapiens	159-163
18796307-5	2008	Chronic corticosterone decreased the levels of cortical glucocorticoid receptors and stress-induced increases in plasma corticosterone levels, and blocked the response of plasma corticosterone to dexamethasone, while isolation rearing did not cause any changes in the glucocorticoid receptor system.	Corticosterone	8-22	nuclear receptor subfamily 3, group C, member 1	Mus musculus	56-79
18796307-8	2008	These results suggest that chronic corticosterone and isolation rearing increase the depressive-like behavior in glucocorticoid receptor-dependent and independent manners, respectively, and that RU-43044 shows an antidepressant-like effect, probably via an inhibition of enhanced prefrontal dopaminergic neurotransmission in these mouse models.	Corticosterone	35-49	nuclear receptor subfamily 3, group C, member 1	Mus musculus	113-136
18930089-10	2008	Further, NDP-MSH similarly reduced food intake during the late phase in all types of mice, including WT, CRFKO, and CRFKO with corticosterone replacement.	Corticosterone	127-141	msh homeobox 1	Mus musculus	13-16
19072255-3	2008	HSP70 transgenic mice displayed increased levels of serum corticosterone and weaker expression and activity of the glucocorticoid receptor in the liver.	Corticosterone	58-72	heat shock protein 1B	Mus musculus	0-5
18675955-0	2008	Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone.	Corticosterone	108-122	brain derived neurotrophic factor	Mus musculus	18-51
18675955-2	2008	METHODS: In adult male mice, we evaluated persistent effects of oral corticosterone (CORT) exposure on anhedonic-like behavior, immobility in the forced swim test (FST), motivational performance in the progressive ratio task, and later endogenous CORT secretion.	Corticosterone	69-83	cortistatin	Mus musculus	85-89
19060181-5	2009	GILZ expression was rapidly upregulated by corticosterone in embryonic pituitary cells.	Corticosterone	43-57	TSC22 domain family member 4	Gallus gallus	0-4
19150652-5	2009	11beta-Hydroxysteroid dehydrogenase 2 (11betaHSD2) has been demonstrated to be a mineralocorticoid receptor (MR) protector by inactivating active glucocorticoids including corticosterone (CORT) in rats, and therefore mutation or suppression of 11betaHSD2 causes hypokalemia and hypertension.	Corticosterone	172-186	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	0-37
19150652-5	2009	11beta-Hydroxysteroid dehydrogenase 2 (11betaHSD2) has been demonstrated to be a mineralocorticoid receptor (MR) protector by inactivating active glucocorticoids including corticosterone (CORT) in rats, and therefore mutation or suppression of 11betaHSD2 causes hypokalemia and hypertension.	Corticosterone	172-186	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	39-49
19150652-5	2009	11beta-Hydroxysteroid dehydrogenase 2 (11betaHSD2) has been demonstrated to be a mineralocorticoid receptor (MR) protector by inactivating active glucocorticoids including corticosterone (CORT) in rats, and therefore mutation or suppression of 11betaHSD2 causes hypokalemia and hypertension.	Corticosterone	172-186	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	244-254
18719621-0	2009	A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF.	Corticosterone	13-27	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	76-80
18719621-0	2009	A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF.	Corticosterone	13-27	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	82-87
18719621-0	2009	A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF.	Corticosterone	13-27	brain-derived neurotrophic factor	Rattus norvegicus	95-99
18800067-0	2009	Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone.	Corticosterone	97-111	prodynorphin	Mus musculus	0-12
18800067-7	2009	Although stress-induced increases in corticosterone levels were attenuated in prodynorphin knockout mice, they were associated with minor increases in depression-like behavior in the tail suspension and forced swim tests.	Corticosterone	37-51	prodynorphin	Mus musculus	78-90
18977372-1	2009	Previously we found that exposure of the amygdala to elevated levels of corticosterone (CORT) induces anxiety-like behavior coupled to colonic hypersensitivity to distension, however, the specific corticoid receptor mediating the CORT responses remains controversial.	Corticosterone	72-86	cortistatin	Rattus norvegicus	88-92
18977372-1	2009	Previously we found that exposure of the amygdala to elevated levels of corticosterone (CORT) induces anxiety-like behavior coupled to colonic hypersensitivity to distension, however, the specific corticoid receptor mediating the CORT responses remains controversial.	Corticosterone	72-86	cortistatin	Rattus norvegicus	230-234
19022273-2	2009	11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) is believed to confer specificity on aldosterone to activate MR by inactivating 11beta-hydroxyglucocorticoids (corticosterone, cortisol) that are 100-1000 times more abundant in plasma than aldosterone and that can also bind and activate MR.	Corticosterone	168-182	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	0-55
19022273-2	2009	11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) is believed to confer specificity on aldosterone to activate MR by inactivating 11beta-hydroxyglucocorticoids (corticosterone, cortisol) that are 100-1000 times more abundant in plasma than aldosterone and that can also bind and activate MR.	Corticosterone	168-182	nuclear receptor subfamily 3 group C member 2	Homo sapiens	118-120
19022273-2	2009	11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) is believed to confer specificity on aldosterone to activate MR by inactivating 11beta-hydroxyglucocorticoids (corticosterone, cortisol) that are 100-1000 times more abundant in plasma than aldosterone and that can also bind and activate MR.	Corticosterone	168-182	nuclear receptor subfamily 3 group C member 2	Homo sapiens	295-297
18817795-5	2009	The present study investigated whether the levels of circulating corticosterone and its binding protein, corticosteroid binding globulin (CBG), are altered with reproductive experience and pup-exposure during late pregnancy and the postpartum.	Corticosterone	65-79	serpin family A member 6	Rattus norvegicus	105-136
18817795-5	2009	The present study investigated whether the levels of circulating corticosterone and its binding protein, corticosteroid binding globulin (CBG), are altered with reproductive experience and pup-exposure during late pregnancy and the postpartum.	Corticosterone	65-79	serpin family A member 6	Rattus norvegicus	138-141
18817795-10	2009	Corticosterone and CBG levels were positively correlated with specific maternal behaviors during the first week postpartum in parturient rats, but not in sensitized rats, suggesting a role for corticosterone in the modulation of maternal behavior in parturient rats alone.	Corticosterone	193-207	serpin family A member 6	Rattus norvegicus	19-22
18835572-4	2009	The exposure to 100 nM corticosterone for 60 min inhibited the CRH-induced ACTH release.	Corticosterone	23-37	corticotropin releasing hormone	Rattus norvegicus	63-66
18835572-7	2009	RT-PCR demonstrated all three subtypes of rat-erg mRNAs in the pituitary and corticosterone increased only erg1 mRNA up to 2.47+/-0.54 fold.	Corticosterone	77-91	potassium voltage-gated channel subfamily H member 2	Rattus norvegicus	107-111
19049807-5	2009	To this extent, we investigated the effects of chronic corticosterone administration on c-fos expression induced by the serotonergic 5-HT(2A/2C) receptor agonist DOI within the PVN.	Corticosterone	55-69	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-93
19084526-7	2009	In addition, depletion of BAG-1 from NPCs induced a decrease in NPCs proliferation in the presence of a stress hormone, corticosterone.	Corticosterone	120-134	BCL2-associated athanogene 1	Mus musculus	26-31
19273359-3	2009	As an adaptive feedback mechanism, SAgs can also activate the hypothalamic pituitary adrenal (HPA) axis by stimulating the release of corticotropin releasing hormone (CRH) from the hypothalamus, adrenocorticotropic hormone (ACTH) from the anterior pituitary, and ultimately corticosterone (CORT) from the adrenal gland.	Corticosterone	274-288	corticotropin releasing hormone	Homo sapiens	134-165
19273359-3	2009	As an adaptive feedback mechanism, SAgs can also activate the hypothalamic pituitary adrenal (HPA) axis by stimulating the release of corticotropin releasing hormone (CRH) from the hypothalamus, adrenocorticotropic hormone (ACTH) from the anterior pituitary, and ultimately corticosterone (CORT) from the adrenal gland.	Corticosterone	274-288	corticotropin releasing hormone	Homo sapiens	167-170
19172483-3	2009	We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-alpha, IL-12p70, and IL-6, among which IL-12p70 and TNF-alpha down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.	Corticosterone	24-38	tumor necrosis factor	Mus musculus	184-193
19172483-3	2009	We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-alpha, IL-12p70, and IL-6, among which IL-12p70 and TNF-alpha down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.	Corticosterone	24-38	interleukin 6	Mus musculus	209-213
19172483-3	2009	We found elevated serum corticosterone after 3 weeks of antigen administration in presence of CFA and a higher serum IL-6 level that also alter lymphoid tissue cytokine responses like TNF-alpha, IL-12p70, and IL-6, among which IL-12p70 and TNF-alpha down-regulate the activity of steroidogenic enzymes in the thymus during an immune response.	Corticosterone	24-38	tumor necrosis factor	Mus musculus	240-249
18789908-5	2008	Serum corticosterone (CORT) level was increased after the cold exposure.	Corticosterone	6-20	cortistatin	Rattus norvegicus	22-26
18601998-9	2008	In a new batch of asymptomatic mice, systemic administration of corticosterone was found to induce aberrations in CA1 dendrites, comparable to the "stress" of chronic disease.	Corticosterone	64-78	carbonic anhydrase 1	Mus musculus	114-117
18657608-0	2008	P38 MAPK mediates COX-2 gene expression by corticosterone in cardiomyocytes.	Corticosterone	43-57	mitogen-activated protein kinase 14	Homo sapiens	0-3
18657608-0	2008	P38 MAPK mediates COX-2 gene expression by corticosterone in cardiomyocytes.	Corticosterone	43-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
18657608-2	2008	Here we report that COX-2 gene promoter mutation studies indicate a role of cAMP response element-binding protein (CREB) in corticosterone-induced COX-2 gene expression.	Corticosterone	124-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	20-25
18657608-2	2008	Here we report that COX-2 gene promoter mutation studies indicate a role of cAMP response element-binding protein (CREB) in corticosterone-induced COX-2 gene expression.	Corticosterone	124-138	cAMP responsive element binding protein 1	Homo sapiens	76-113
18657608-2	2008	Here we report that COX-2 gene promoter mutation studies indicate a role of cAMP response element-binding protein (CREB) in corticosterone-induced COX-2 gene expression.	Corticosterone	124-138	cAMP responsive element binding protein 1	Homo sapiens	115-119
18657608-2	2008	Here we report that COX-2 gene promoter mutation studies indicate a role of cAMP response element-binding protein (CREB) in corticosterone-induced COX-2 gene expression.	Corticosterone	124-138	prostaglandin-endoperoxide synthase 2	Homo sapiens	147-152
18657608-3	2008	Corticosterone causes activation of p38 MAPK and subsequent CREB phosphorylation at serine 133 in cardiomyocytes.	Corticosterone	0-14	mitogen-activated protein kinase 14	Homo sapiens	36-39
18657608-3	2008	Corticosterone causes activation of p38 MAPK and subsequent CREB phosphorylation at serine 133 in cardiomyocytes.	Corticosterone	0-14	cAMP responsive element binding protein 1	Homo sapiens	60-64
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	57-71	mitogen-activated protein kinase 14	Homo sapiens	18-21
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	57-71	cAMP responsive element binding protein 1	Homo sapiens	86-90
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	57-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	111-116
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	57-71	cAMP responsive element binding protein 1	Homo sapiens	169-173
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	57-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	214-219
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	183-197	mitogen-activated protein kinase 14	Homo sapiens	18-21
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	183-197	cAMP responsive element binding protein 1	Homo sapiens	86-90
18657608-4	2008	The inhibitors of p38 MAPK, SB202190 and SB203580, block corticosterone from inducing CREB phosphorylation and COX-2 gene expression while dominant-negative p38 MAPK or CREB prevents corticosterone from activating COX-2 promoter.	Corticosterone	183-197	mitogen-activated protein kinase 14	Homo sapiens	157-160
18657608-6	2008	While glucocorticoid receptor antagonist mifepristone inhibits COX-2 gene induction by corticosterone, mifepristone fails to inhibit p38 MAPK activation or CREB phosphorylation.	Corticosterone	87-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
18779947-2	2008	Inactive glucocorticoids (cortisone, 11-dehydrocorticosterone) are converted to active cortisol and corticosterone by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which requires NADPH as cofactor, which is generated by hexose-6-phosphate dehydrogenase (H6PDH).	Corticosterone	47-61	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	118-160
19922359-4	2009	Plasma corticosterone (CORT) concentration was increased with lesion of the ADTN in maternally separated rats.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
18779947-2	2008	Inactive glucocorticoids (cortisone, 11-dehydrocorticosterone) are converted to active cortisol and corticosterone by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which requires NADPH as cofactor, which is generated by hexose-6-phosphate dehydrogenase (H6PDH).	Corticosterone	47-61	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	162-173
18779947-10	2008	Reduction of 11beta-HSD1 activity with specific inhibitors or in experiments carried out in H6pdh-null mice reversed the effects of 11-dehydrocorticosterone, but had no effect following treatment with corticosterone.	Corticosterone	142-156	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	13-24
18931068-8	2008	Males with low corticosterone concentrations and high viral load had elevated regulatory T-cell responses and expression of matrix metalloprotease (MMP)-9.	Corticosterone	15-29	matrix metallopeptidase 9	Homo sapiens	124-154
18790054-6	2008	These findings led us to investigate the circulating and urinary steroid levels of Nas1(-/-) and Nas1(+/+) mice, which revealed reduced blood levels of corticosterone ( approximately 50% decrease), dehydroepiandrosterone (DHEA, approximately 30% decrease) and DHEA-sulfate ( approximately 40% decrease), and increased urinary corticosterone ( approximately 16-fold increase) and DHEA ( approximately 40% increase) levels in Nas1(-/-) mice.	Corticosterone	152-166	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	83-87
18790054-6	2008	These findings led us to investigate the circulating and urinary steroid levels of Nas1(-/-) and Nas1(+/+) mice, which revealed reduced blood levels of corticosterone ( approximately 50% decrease), dehydroepiandrosterone (DHEA, approximately 30% decrease) and DHEA-sulfate ( approximately 40% decrease), and increased urinary corticosterone ( approximately 16-fold increase) and DHEA ( approximately 40% increase) levels in Nas1(-/-) mice.	Corticosterone	152-166	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	97-101
18790054-6	2008	These findings led us to investigate the circulating and urinary steroid levels of Nas1(-/-) and Nas1(+/+) mice, which revealed reduced blood levels of corticosterone ( approximately 50% decrease), dehydroepiandrosterone (DHEA, approximately 30% decrease) and DHEA-sulfate ( approximately 40% decrease), and increased urinary corticosterone ( approximately 16-fold increase) and DHEA ( approximately 40% increase) levels in Nas1(-/-) mice.	Corticosterone	152-166	solute carrier family 13 (sodium/sulfate symporters), member 1	Mus musculus	97-101
18951918-11	2008	Corticosterone changes differed markedly in FI vs. NFI groups in both genders, demonstrating a critical role for behavioral history and raising caution about extrapolating biochemical markers across such conditions.	Corticosterone	0-14	nuclear factor I C	Homo sapiens	51-54
19211990-6	2008	The present study suggests that liver CYP is regulated by the dopaminergic tuberoinfundibular pathway via growth hormone and triiodothyronine, while the mesolimbic pathway influences this enzyme via corticosterone and triiodothyronine.	Corticosterone	199-213	peptidylprolyl isomerase G	Homo sapiens	38-41
18931171-5	2008	Moreover, in the line selected for high antibody titers (ND3-L), corticosterone levels were positively correlated to ND3 (r = 0.41 and 0.47) and negatively correlated to CC (r = -0.48).	Corticosterone	65-79	ND3	Gallus gallus	57-60
18617609-3	2008	The data indicate that the forebrain GR is necessary for maintaining basal regulation of corticosterone secretion in the morning, confirming its role in HPA axis regulation.	Corticosterone	89-103	nuclear receptor subfamily 3, group C, member 1	Mus musculus	37-39
18931171-5	2008	Moreover, in the line selected for high antibody titers (ND3-L), corticosterone levels were positively correlated to ND3 (r = 0.41 and 0.47) and negatively correlated to CC (r = -0.48).	Corticosterone	65-79	ND3	Gallus gallus	117-120
18722505-5	2008	These data suggest that PACAP signaling pathway is involved in light-induced stimulation of RSNA and plasma corticosterone release through SCN of brain.	Corticosterone	108-122	adenylate cyclase activating polypeptide 1	Mus musculus	24-29
18775731-4	2008	Continuous administration of IFN-alpha to mice decreased the rhythm amplitude of locomotor activity, body temperature, leukocyte counts, and plasma corticosterone levels.	Corticosterone	148-162	interferon alpha	Mus musculus	29-38
18797300-4	2008	After acute stress, corticosterone and adrenocorticotropic hormone increased similarly in PrP+/+ and PrP 0/0 mice.	Corticosterone	20-34	prion protein	Mus musculus	90-93
18797300-4	2008	After acute stress, corticosterone and adrenocorticotropic hormone increased similarly in PrP+/+ and PrP 0/0 mice.	Corticosterone	20-34	prion protein	Mus musculus	101-104
18797300-5	2008	Adrenocorticotropic hormone, however, remained elevated in PrP+/+ 0/0 mice at corticosterone levels that are inhibitory in PrP mice.	Corticosterone	78-92	pro-opiomelanocortin-alpha	Mus musculus	0-27
18797300-5	2008	Adrenocorticotropic hormone, however, remained elevated in PrP+/+ 0/0 mice at corticosterone levels that are inhibitory in PrP mice.	Corticosterone	78-92	prion protein	Mus musculus	59-62
18797300-6	2008	Pretreatment with corticosterone or dexamethasone inhibited stress-induced elevation of adrenocorticotropic hormone in PrP+/+ but not in PrP 0/0 mice.	Corticosterone	18-32	pro-opiomelanocortin-alpha	Mus musculus	88-115
18797300-6	2008	Pretreatment with corticosterone or dexamethasone inhibited stress-induced elevation of adrenocorticotropic hormone in PrP+/+ but not in PrP 0/0 mice.	Corticosterone	18-32	prion protein	Mus musculus	119-122
18833324-9	2008	In addition, loss of CB1 resulted in aberrant secretions of corticotrophin-releasing hormone and corticosterone during late gestation.	Corticosterone	97-111	cannabinoid receptor 1 (brain)	Mus musculus	21-24
18833324-14	2008	Moreover, CB1 inactivation resulted in aberrant corticotrophin-releasing hormone and corticosterone activities prior to parturition, suggesting that CB1 regulates labor by interacting with the corticotrophin-releasing hormone-driven endocrine axis.	Corticosterone	85-99	cannabinoid receptor 1 (brain)	Mus musculus	10-13
18833324-14	2008	Moreover, CB1 inactivation resulted in aberrant corticotrophin-releasing hormone and corticosterone activities prior to parturition, suggesting that CB1 regulates labor by interacting with the corticotrophin-releasing hormone-driven endocrine axis.	Corticosterone	85-99	cannabinoid receptor 1 (brain)	Mus musculus	149-152
18666205-4	2008	In this study, we addressed the effects of MD on hippocampal glial cells and the possible relationship with changes in plasma corticosterone (CORT) levels.	Corticosterone	126-140	cortistatin	Rattus norvegicus	142-146
18650268-3	2008	With isolated neonatal cardiomyocytes, corticosterone (CT) at physiologically relevant doses (0.01-1 microM) induces the expression of COX-2 gene.	Corticosterone	39-53	cytochrome c oxidase II, mitochondrial	Mus musculus	135-140
18650268-3	2008	With isolated neonatal cardiomyocytes, corticosterone (CT) at physiologically relevant doses (0.01-1 microM) induces the expression of COX-2 gene.	Corticosterone	55-57	cytochrome c oxidase II, mitochondrial	Mus musculus	135-140
18650268-7	2008	The glucocorticoid receptor (GR) antagonist mifepristone (MF) prevented CT from inducing COX-2 gene, suggesting a GR-dependent induction in cardiomyocytes.	Corticosterone	72-74	nuclear receptor subfamily 3, group C, member 1	Mus musculus	4-27
18650268-7	2008	The glucocorticoid receptor (GR) antagonist mifepristone (MF) prevented CT from inducing COX-2 gene, suggesting a GR-dependent induction in cardiomyocytes.	Corticosterone	72-74	nuclear receptor subfamily 3, group C, member 1	Mus musculus	29-31
18650268-7	2008	The glucocorticoid receptor (GR) antagonist mifepristone (MF) prevented CT from inducing COX-2 gene, suggesting a GR-dependent induction in cardiomyocytes.	Corticosterone	72-74	cytochrome c oxidase II, mitochondrial	Mus musculus	89-94
18650268-7	2008	The glucocorticoid receptor (GR) antagonist mifepristone (MF) prevented CT from inducing COX-2 gene, suggesting a GR-dependent induction in cardiomyocytes.	Corticosterone	72-74	nuclear receptor subfamily 3, group C, member 1	Mus musculus	114-116
18650268-8	2008	COX-2 gene promoter deletion and mutation studies indicate a role of CCAAT/enhancer binding protein-beta (C/EBP-beta) in CT-induced COX-2 gene expression.	Corticosterone	121-123	cytochrome c oxidase II, mitochondrial	Mus musculus	0-5
18650268-8	2008	COX-2 gene promoter deletion and mutation studies indicate a role of CCAAT/enhancer binding protein-beta (C/EBP-beta) in CT-induced COX-2 gene expression.	Corticosterone	121-123	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	69-104
18650268-8	2008	COX-2 gene promoter deletion and mutation studies indicate a role of CCAAT/enhancer binding protein-beta (C/EBP-beta) in CT-induced COX-2 gene expression.	Corticosterone	121-123	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	106-116
18650268-8	2008	COX-2 gene promoter deletion and mutation studies indicate a role of CCAAT/enhancer binding protein-beta (C/EBP-beta) in CT-induced COX-2 gene expression.	Corticosterone	121-123	cytochrome c oxidase II, mitochondrial	Mus musculus	132-137
18650268-9	2008	Chromatin immunoprecipitation assays revealed that CT caused the binding of both GR and C/EBP-beta to COX-2 promoter, while MF pretreatment blocked such binding.	Corticosterone	51-53	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	88-98
18650268-9	2008	Chromatin immunoprecipitation assays revealed that CT caused the binding of both GR and C/EBP-beta to COX-2 promoter, while MF pretreatment blocked such binding.	Corticosterone	51-53	cytochrome c oxidase II, mitochondrial	Mus musculus	102-107
18650268-10	2008	Coimmunoprecipitation experiments demonstrated that CT treatment induced the interaction of GR with C/EBP-beta.	Corticosterone	52-54	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	100-110
18798907-7	2008	The aim of this study was to compare changes in ACTH and corticosterone (CORT) concentration after various stressors (immobilization, cold and heat), as well as after injection of investigated Tyr-MIF-1s peptides.	Corticosterone	57-71	cortistatin	Homo sapiens	73-77
18798907-11	2008	Moreover, all the investigated peptides from Tyr-MIF-1 family, administered after application of stressors, inhibited the elevations in adrenocorticotropic hormone (ACTH) and corticosterone (CORT) plasma concentrations significantly.	Corticosterone	175-189	homocysteine inducible ER protein with ubiquitin like domain 1	Homo sapiens	49-54
18798907-11	2008	Moreover, all the investigated peptides from Tyr-MIF-1 family, administered after application of stressors, inhibited the elevations in adrenocorticotropic hormone (ACTH) and corticosterone (CORT) plasma concentrations significantly.	Corticosterone	175-189	cortistatin	Homo sapiens	191-195
18562161-4	2008	Systemic administration of corticosterone could mimic the effects of psychological stress on ICAM-1 expression.	Corticosterone	27-41	intercellular adhesion molecule 1	Mus musculus	93-99
18556350-0	2008	A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice.	Corticosterone	92-106	phosphoglycolate phosphatase	Mus musculus	19-33
18556350-10	2008	This could explain previous findings from systemic administration studies, showing an effect of P-gp not only for dexamethasone and cortisol, but also for corticosterone.	Corticosterone	155-169	phosphoglycolate phosphatase	Mus musculus	96-100
18556350-11	2008	This in situ study highlights the different affinities of dexamethasone, cortisol, and corticosterone for P-gp, and suggests that the entry of the endogenous glucocorticoids into the mouse brain is not tightly regulated by P-gp.	Corticosterone	87-101	phosphoglycolate phosphatase	Mus musculus	106-110
18583419-6	2008	Second, we observe that ob/ob mice treated with low-dose leptin peripherally but not centrally exhibit increased thymocyte cellularity in the absence of any weight loss or significant reduction in systemic corticosterone levels.	Corticosterone	206-220	leptin	Mus musculus	57-63
18615595-6	2008	Both cell types expressed the GR and treatment with dexamethasone or corticosterone downregulated total cellular GR levels while increasing nuclear translocation of the GR in both L6 and C2C12 myotubes.	Corticosterone	69-83	nuclear receptor subfamily 3, group C, member 1	Mus musculus	30-32
18615595-6	2008	Both cell types expressed the GR and treatment with dexamethasone or corticosterone downregulated total cellular GR levels while increasing nuclear translocation of the GR in both L6 and C2C12 myotubes.	Corticosterone	69-83	nuclear receptor subfamily 3, group C, member 1	Mus musculus	113-115
18615595-6	2008	Both cell types expressed the GR and treatment with dexamethasone or corticosterone downregulated total cellular GR levels while increasing nuclear translocation of the GR in both L6 and C2C12 myotubes.	Corticosterone	69-83	nuclear receptor subfamily 3, group C, member 1	Mus musculus	113-115
18615595-7	2008	The GR antagonist RU38486 inhibited the dexamethasone- and corticosterone-induced increases in atrogin-1 and MuRF1 expression in L6 myotubes but not in C2C12 myotubes.	Corticosterone	59-73	nuclear receptor subfamily 3, group C, member 1	Mus musculus	4-6
18615595-7	2008	The GR antagonist RU38486 inhibited the dexamethasone- and corticosterone-induced increases in atrogin-1 and MuRF1 expression in L6 myotubes but not in C2C12 myotubes.	Corticosterone	59-73	F-box protein 32	Mus musculus	95-104
18615595-7	2008	The GR antagonist RU38486 inhibited the dexamethasone- and corticosterone-induced increases in atrogin-1 and MuRF1 expression in L6 myotubes but not in C2C12 myotubes.	Corticosterone	59-73	tripartite motif-containing 63	Mus musculus	109-114
19967059-6	2008	In fasted adrenalectomized rats, corticosterone replacement increased GHRH-R mRNA levels and intensified the fasting-induced decrease in GHRH, but did not alter NPY or GHS-R response.	Corticosterone	33-47	growth hormone releasing hormone receptor	Rattus norvegicus	70-76
19967059-6	2008	In fasted adrenalectomized rats, corticosterone replacement increased GHRH-R mRNA levels and intensified the fasting-induced decrease in GHRH, but did not alter NPY or GHS-R response.	Corticosterone	33-47	growth hormone releasing hormone	Rattus norvegicus	70-74
18657370-4	2008	injection of high dose corticosterone (CORT) in rats.	Corticosterone	23-37	cortistatin	Rattus norvegicus	39-43
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	Corticosterone	81-95	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18657281-2	2008	While investigating whether phosphatidylinositol 3 kinase (PI3K) plays a role in corticosterone (CT)-induced COX-2, we found that LY294002 (LY29) but not wortmannin (WM) attenuates CT from inducing COX-2 gene expression.	Corticosterone	97-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	109-114
18657281-6	2008	These data suggest PI3K-independent mechanisms in regulating CT-induced COX-2 expression.	Corticosterone	61-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
18657281-12	2008	These data suggest a possible role of calcium instead of PI3K in CT-induced COX-2 expression in cardiomyocytes.	Corticosterone	65-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	76-81
18687386-0	2008	Exogenous corticosterone reduces L-DOPA-induced dyskinesia in the hemi-parkinsonian rat: role for interleukin-1beta.	Corticosterone	10-24	interleukin 1 beta	Rattus norvegicus	98-115
18808689-10	2008	Corticosterone, dihydrocorticosterone and, most prominently dexamethasone, counteracted the deleterious effects of IFN-gamma and TNF-alpha on cell survival, A2B5-immunostaining and expression of myelin basic protein.	Corticosterone	0-14	interferon gamma	Rattus norvegicus	115-124
18808689-10	2008	Corticosterone, dihydrocorticosterone and, most prominently dexamethasone, counteracted the deleterious effects of IFN-gamma and TNF-alpha on cell survival, A2B5-immunostaining and expression of myelin basic protein.	Corticosterone	0-14	tumor necrosis factor	Rattus norvegicus	129-138
18808689-10	2008	Corticosterone, dihydrocorticosterone and, most prominently dexamethasone, counteracted the deleterious effects of IFN-gamma and TNF-alpha on cell survival, A2B5-immunostaining and expression of myelin basic protein.	Corticosterone	0-14	myelin basic protein	Rattus norvegicus	195-215
18625285-0	2008	Corticosterone release in oxytocin gene deletion mice following exposure to psychogenic versus non-psychogenic stress.	Corticosterone	0-14	oxytocin	Mus musculus	26-34
18625285-24	2008	Amico, Corticosterone release is heightened in food or water deprived oxytocin deficient male mice, Brain Res.	Corticosterone	7-21	oxytocin	Mus musculus	70-78
18640111-3	2008	However, 5-HT1A receptor agonists increase plasma corticosterone and many antipsychotics disturb the regulation of glucose.	Corticosterone	50-64	5-hydroxytryptamine receptor 1A	Rattus norvegicus	9-15
18836910-20	2008	Lipoprotein lipase activities in either cervical or abdominal adipose tissues, rather than in thigh fat tissue, were significantly elevated by either glucose or corticosterone treatment.	Corticosterone	161-175	lipoprotein lipase	Gallus gallus	0-18
18566117-6	2008	In response to increased SF-1 expression and/or treatment with retinoic acid, AMCs were much more prone to produce adrenal steroid, corticosterone rather than gonadal steroid, testosterone, whereas the contrary was evident in BMCs.	Corticosterone	132-146	splicing factor 1	Mus musculus	25-29
18679562-1	2008	We studied the effect of long-term application of corticosterone (CORT) s.c. the equivalent of cortisol in rats, on behavior, oxidative and energy metabolism in brain parietotemporal cortex and hippocampus of 1-year-old male Wistar rats.	Corticosterone	50-64	cortistatin	Rattus norvegicus	66-70
18624927-7	2008	CORT (500 nm) or DEX (50 nm) treatment for 24 h significantly inhibited CRH expression in the parvocellular neurones and this effect of corticosteroids was not affected following blockade of voltage dependent sodium channels by TTX.	Corticosterone	0-4	corticotropin releasing hormone	Rattus norvegicus	72-75
18624927-8	2008	Forskolin-stimulated CRH mRNA levels in the paraventricular nucleus were also inhibited by CORT or DEX in the presence and in the absence of TTX.	Corticosterone	91-95	corticotropin releasing hormone	Rattus norvegicus	21-24
18953098-18	2008	Crowding stress for 7 days markedly impaired the IL-1beta-induced ACTH and corticosterone secretion.	Corticosterone	75-89	interleukin 1 beta	Rattus norvegicus	49-57
18599619-3	2008	Corticosterone (CT) at physiologically relevant doses (0.05-1 microm) induces transcriptional activation of COX-1 gene as shown by nuclear run-on and promoter reporter assays.	Corticosterone	0-14	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	108-113
18599619-3	2008	Corticosterone (CT) at physiologically relevant doses (0.05-1 microm) induces transcriptional activation of COX-1 gene as shown by nuclear run-on and promoter reporter assays.	Corticosterone	16-18	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	108-113
18599619-4	2008	An antagonist of glucocorticoid receptor (GR), mifepristone, prevented CT from inducing COX-1.	Corticosterone	71-73	nuclear receptor subfamily 3 group C member 1	Homo sapiens	17-40
18599619-4	2008	An antagonist of glucocorticoid receptor (GR), mifepristone, prevented CT from inducing COX-1.	Corticosterone	71-73	nuclear receptor subfamily 3 group C member 1	Homo sapiens	42-44
18599619-4	2008	An antagonist of glucocorticoid receptor (GR), mifepristone, prevented CT from inducing COX-1.	Corticosterone	71-73	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	88-93
18602903-5	2008	We also aimed to clarify whether the increase in plasma corticosterone in food-anticipating rats coincides with the increase in expression of corticotropin releasing factor (CRF) mRNA in the paraventricular hypothalamic nucleus (PVH).	Corticosterone	56-70	corticotropin releasing hormone	Rattus norvegicus	142-172
18704796-0	2008	Corticosterone administration and high-energy feed results in enhanced fat accumulation and insulin resistance in broiler chickens.	Corticosterone	0-14	insulin	Gallus gallus	92-99
18369660-8	2008	were significantly lower, but 24-h urinary aldosterone was significantly higher, and corticosterone excretion tended to be higher in gsk3 ( KI ) than in gsk3 ( WT ) mice.	Corticosterone	85-99	glycogen synthase kinase 3 beta	Mus musculus	133-137
18706086-11	2008	In contrast, these MCP-1-/- mice showed significantly lower inductions of brain pro-inflammatory cytokines and chemokines, fewer activated microglia, and a reduction in serum corticosterone levels.	Corticosterone	175-189	mast cell protease 1	Mus musculus	19-24
18559987-2	2008	The main hormone regulating the production of corticosterone is the proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH).	Corticosterone	46-60	pro-opiomelanocortin-alpha	Mus musculus	68-87
18559987-2	2008	The main hormone regulating the production of corticosterone is the proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH).	Corticosterone	46-60	pro-opiomelanocortin-alpha	Mus musculus	89-93
18559987-2	2008	The main hormone regulating the production of corticosterone is the proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH).	Corticosterone	46-60	pro-opiomelanocortin-alpha	Mus musculus	103-130
18559987-2	2008	The main hormone regulating the production of corticosterone is the proopiomelanocortin (POMC)-derived adrenocorticotropic hormone (ACTH).	Corticosterone	46-60	pro-opiomelanocortin-alpha	Mus musculus	132-136
18559987-4	2008	However, pharmacological amounts of ACTH delivered continuously elicit corticosterone production over time.	Corticosterone	71-85	pro-opiomelanocortin-alpha	Mus musculus	36-40
18559987-7	2008	However, discontinuation of ACTH treatment stops corticosterone production despite the presence of adrenal CE.	Corticosterone	49-63	pro-opiomelanocortin-alpha	Mus musculus	28-32
18559987-8	2008	Failure of corticosterone production by POMC(-/-) adrenals occurs despite the constitutive presence of transcripts of genes required for cholesterol metabolism and steroidogenesis.	Corticosterone	11-25	pro-opiomelanocortin-alpha	Mus musculus	40-44
18559987-10	2008	Our studies reveal that failure of corticosterone production of POMC(-/-) adrenal glands and its pharmacological reconstitution by ACTH are not mediated by any one individual protein, but rather as an integrated effect on multiple factors from import of the substrate cholesterol to its conversion to corticosterone.	Corticosterone	35-49	pro-opiomelanocortin-alpha	Mus musculus	64-68
18559987-10	2008	Our studies reveal that failure of corticosterone production of POMC(-/-) adrenal glands and its pharmacological reconstitution by ACTH are not mediated by any one individual protein, but rather as an integrated effect on multiple factors from import of the substrate cholesterol to its conversion to corticosterone.	Corticosterone	301-315	pro-opiomelanocortin-alpha	Mus musculus	64-68
18547575-1	2008	Corticosterone (CORT) levels in free-living animals are seasonally modulated and vary with environmental conditions.	Corticosterone	0-14	CORT	Gallus gallus	16-20
18335507-5	2008	StAR mRNA and protein levels were significantly increased in Leydig cells of corticosterone-deficient animals.	Corticosterone	77-91	steroidogenic acute regulatory protein	Homo sapiens	0-4
18622402-2	2008	Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content.	Corticosterone	73-87	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	165-170
18622402-2	2008	Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content.	Corticosterone	73-87	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	215-220
18622402-3	2008	Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.	Corticosterone	13-27	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	73-78
18622402-3	2008	Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.	Corticosterone	164-178	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	73-78
18648056-1	2008	Two experiments were conducted to investigate the effect of acute preslaughter stress mimicked by exogenous corticosterone (CORT) administration on postmortem muscle metabolism of broiler chickens.	Corticosterone	108-122	CORT	Gallus gallus	124-128
18491079-4	2008	RESULTS: The impact of an acute bolus injection of IL-1beta (1.0 microg) on plasma corticosterone and on circulating IL-1beta, IL-6, and TNF-alpha were diminished following 5-day IL-1beta treatment, although high levels of sickness were still apparent.	Corticosterone	83-97	interleukin 1 beta	Mus musculus	51-59
18491079-5	2008	When IL-1beta (1.0 or 2.0 mug/day) was continuously infused over 3 days, plasma corticosterone and sickness were elevated, but these effects were attenuated after 7 days (subchronic) of treatment.	Corticosterone	80-94	interleukin 1 beta	Mus musculus	5-13
18583010-2	2008	Stress and high levels of corticosterone (CORT) on the contrary inhibit neurogenesis.	Corticosterone	26-40	cortistatin	Rattus norvegicus	42-46
18597948-13	2008	UII increased HR and plasma glucose and corticosterone in conscious rats.	Corticosterone	40-54	urotensin 2	Rattus norvegicus	0-3
18704796-14	2008	Plasma concentrations of glucose, insulin, triglyceride, non-esterified fatty acids (NEFA) and very low density lipoprotein were increased by corticosterone treatment regardless of diet treatment.	Corticosterone	142-156	insulin	Gallus gallus	34-41
18704796-17	2008	Lipoprotein lipase (LPL) activities in adipose tissues may have been up-regulated by corticosterone treatment and showed tissue specificity.	Corticosterone	85-99	lipoprotein lipase	Gallus gallus	0-18
18704796-17	2008	Lipoprotein lipase (LPL) activities in adipose tissues may have been up-regulated by corticosterone treatment and showed tissue specificity.	Corticosterone	85-99	lipoprotein lipase	Gallus gallus	20-23
18704796-21	2008	The induced insulin resistance and enhanced hepatic de novo lipogenesis by corticosterone are likely to be responsible for the increased fat deposition.	Corticosterone	75-89	insulin	Gallus gallus	12-19
18584335-0	2008	Inhibitors of GSK-3 prevent corticosterone from inducing COX-1 expression in cardiomyocytes.	Corticosterone	28-42	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	57-62
18534559-0	2008	Regulation of hippocampal alpha1d adrenergic receptor mRNA by corticosterone in adrenalectomized rats.	Corticosterone	62-76	adrenoceptor alpha 1D	Rattus norvegicus	26-53
18403478-6	2008	In stressed and unstressed animals, the number of androgen receptors and arginine vasopressin-expressing neurons in both of these nuclei correlated negatively with corticosterone concentrations in plasma and Fos levels in the paraventricular nucleus.	Corticosterone	164-178	arginine vasopressin	Rattus norvegicus	82-93
18372328-3	2008	The GR mutants die about 1 wk after birth and display a fulminant increase in plasma corticosterone as well as a severe histopathological phenotype.	Corticosterone	85-99	nuclear receptor subfamily 3, group C, member 1	Mus musculus	4-6
18584335-8	2008	We conclude that GSK-3 inhibitors block CT from inducing COX-1 gene expression via a mechanism beyond GR and Sp3 transcription factor.	Corticosterone	40-42	prostaglandin-endoperoxide synthase 1	Rattus norvegicus	57-62
18584335-8	2008	We conclude that GSK-3 inhibitors block CT from inducing COX-1 gene expression via a mechanism beyond GR and Sp3 transcription factor.	Corticosterone	40-42	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	102-104
18584335-8	2008	We conclude that GSK-3 inhibitors block CT from inducing COX-1 gene expression via a mechanism beyond GR and Sp3 transcription factor.	Corticosterone	40-42	Sp3 transcription factor	Rattus norvegicus	109-112
18472343-8	2008	The three groups exhibited the nocturnal corticosterone increase, in addition the W-SP and W-AP groups showed increase of plasma corticosterone associated with the start of the working session.	Corticosterone	129-143	whey acidic protein	Rattus norvegicus	82-95
18662341-1	2008	Previous research has shown that chronic corticosterone treatment increases the expression of corticotrophin-releasing hormone (CRH) mRNA at the central nucleus of the amygdala (CeA).	Corticosterone	41-55	corticotropin releasing hormone	Rattus norvegicus	94-126
18662341-1	2008	Previous research has shown that chronic corticosterone treatment increases the expression of corticotrophin-releasing hormone (CRH) mRNA at the central nucleus of the amygdala (CeA).	Corticosterone	41-55	corticotropin releasing hormone	Rattus norvegicus	128-131
18662341-1	2008	Previous research has shown that chronic corticosterone treatment increases the expression of corticotrophin-releasing hormone (CRH) mRNA at the central nucleus of the amygdala (CeA).	Corticosterone	41-55	carcinoembryonic antigen gene family 4	Rattus norvegicus	178-181
18662341-3	2008	Using in-vivo microdialysis, this study examined the effects of corticosterone treatment on the release of CRH and GRP in response to an airpuff challenge at two forebrain regions, the CeA and medial prefrontal cortex.	Corticosterone	64-78	corticotropin releasing hormone	Rattus norvegicus	107-110
18662341-3	2008	Using in-vivo microdialysis, this study examined the effects of corticosterone treatment on the release of CRH and GRP in response to an airpuff challenge at two forebrain regions, the CeA and medial prefrontal cortex.	Corticosterone	64-78	gastrin releasing peptide	Rattus norvegicus	115-118
18662341-5	2008	We found that, at both regions, the airpuff-induced CRH and GRP release were enhanced in the corticosterone pellet-implanted rats as compared with the release observed in the vehicle-implanted control rats.	Corticosterone	93-107	corticotropin releasing hormone	Rattus norvegicus	52-55
18662341-5	2008	We found that, at both regions, the airpuff-induced CRH and GRP release were enhanced in the corticosterone pellet-implanted rats as compared with the release observed in the vehicle-implanted control rats.	Corticosterone	93-107	gastrin releasing peptide	Rattus norvegicus	60-63
18662341-6	2008	These findings suggest that chronic corticosterone exposure potentiates the stressor-elicited release of CRH and GRP.	Corticosterone	36-50	corticotropin releasing hormone	Rattus norvegicus	105-108
18662341-6	2008	These findings suggest that chronic corticosterone exposure potentiates the stressor-elicited release of CRH and GRP.	Corticosterone	36-50	gastrin releasing peptide	Rattus norvegicus	113-116
18346130-10	2008	CONCLUSIONS: Our results suggest that the effect of sialoadenectomy on LPS/GalN-induced liver toxicity may be the consequence of an altered cytokine production by the liver and a reduced CS release from adrenal glands.	Corticosterone	187-189	galanin and GMAP prepropeptide	Mus musculus	75-79
17700577-6	2008	The blunting of the adrenocortical activation in IL-1rKO mice may play a causal role in their resistance to depression, because removal of endogenous glucocorticoids by adrenalectomy also abolished the depressive-like effects of CMS, whereas chronic administration of corticosterone for 4 weeks produced depressive symptoms and reduced neurogenesis in both WT and IL-1rKO mice.	Corticosterone	268-282	interleukin 1 complex	Mus musculus	49-53
18399546-6	2008	Treatment with corticosterone (CORT) for 4 days significantly decreased GR-ir in the POA, mp, medial amygdala (MeA), BNST, and rostral pars distalis.	Corticosterone	15-29	nuclear receptor subfamily 3 group C member 1 S homeolog	Xenopus laevis	72-74
18420743-6	2008	In response to ACTH (but not vasopressin), cultures of adrenal gland cells from 11-d diabetic mice secreted higher amounts of corticosterone than control cells.	Corticosterone	126-140	pro-opiomelanocortin-alpha	Mus musculus	15-19
18399546-6	2008	Treatment with corticosterone (CORT) for 4 days significantly decreased GR-ir in the POA, mp, medial amygdala (MeA), BNST, and rostral pars distalis.	Corticosterone	31-35	nuclear receptor subfamily 3 group C member 1 S homeolog	Xenopus laevis	72-74
18485334-6	2008	In the hippocampus, a single corticosterone dose (10 mg/kg, s.c.) caused a widespread and transient reduction of fosB mRNA after 0.8 h, whereas changes in both c-fos and fra-1 mRNA levels were restricted to the dentate gyrus region.	Corticosterone	29-43	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	113-117
18423439-0	2008	Role of brain nicotinic acetylcholine receptor in centrally administered corticotropin-releasing factor-induced elevation of plasma corticosterone in rats.	Corticosterone	132-146	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	14-46
18423439-0	2008	Role of brain nicotinic acetylcholine receptor in centrally administered corticotropin-releasing factor-induced elevation of plasma corticosterone in rats.	Corticosterone	132-146	corticotropin releasing hormone	Rattus norvegicus	73-103
18423439-1	2008	The present study was undertaken to clarify the central mechanisms involved in the intracerebroventricularly administered corticotropin-releasing factor-induced elevation of plasma corticosterone in urethane- and alpha-chloralose-anesthetized rats using microdialysis and immunohistochemical techniques.	Corticosterone	181-195	corticotropin releasing hormone	Rattus norvegicus	122-152
18423439-4	2008	In addition, the corticotropin-releasing factor-induced elevation of noradrenaline release in the hypothalamic paraventricular nucleus and plasma corticosterone were abolished by hexamethonium, a non-selective nicotinic acetylcholine receptor antagonist, at 1.8 micromol/animal, intracerebroventricularly, and alpha-conotoxin MII, a potent alpha(3)beta(2) nicotinic acetylcholine receptor antagonist, at 30 nmol/animal, i.c.v.	Corticosterone	146-160	corticotropin releasing hormone	Rattus norvegicus	17-47
18423439-4	2008	In addition, the corticotropin-releasing factor-induced elevation of noradrenaline release in the hypothalamic paraventricular nucleus and plasma corticosterone were abolished by hexamethonium, a non-selective nicotinic acetylcholine receptor antagonist, at 1.8 micromol/animal, intracerebroventricularly, and alpha-conotoxin MII, a potent alpha(3)beta(2) nicotinic acetylcholine receptor antagonist, at 30 nmol/animal, i.c.v.	Corticosterone	146-160	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	210-242
18455806-1	2008	Administration of the endotoxin, lipopolysaccharide (LPS) diminished motor activity and increased plasma corticosterone as well as circulating levels of interleukin-1beta (IL-1beta), IL-6, tumor necrosis-factor-alpha (TNF-alpha) and IL-10.	Corticosterone	105-119	toll-like receptor 4	Mus musculus	53-56
18455806-2	2008	Among cyclooxygenase-2 (COX-2) knockout mice the behavioural, corticosterone and cytokine variations promoted by LPS were moderately (home cage activity, corticosterone, TNF-alpha) or largely (IL-6) reduced.	Corticosterone	62-76	prostaglandin-endoperoxide synthase 2	Mus musculus	6-22
18455806-2	2008	Among cyclooxygenase-2 (COX-2) knockout mice the behavioural, corticosterone and cytokine variations promoted by LPS were moderately (home cage activity, corticosterone, TNF-alpha) or largely (IL-6) reduced.	Corticosterone	62-76	prostaglandin-endoperoxide synthase 2	Mus musculus	24-29
18455806-2	2008	Among cyclooxygenase-2 (COX-2) knockout mice the behavioural, corticosterone and cytokine variations promoted by LPS were moderately (home cage activity, corticosterone, TNF-alpha) or largely (IL-6) reduced.	Corticosterone	62-76	toll-like receptor 4	Mus musculus	113-116
18455806-2	2008	Among cyclooxygenase-2 (COX-2) knockout mice the behavioural, corticosterone and cytokine variations promoted by LPS were moderately (home cage activity, corticosterone, TNF-alpha) or largely (IL-6) reduced.	Corticosterone	154-168	prostaglandin-endoperoxide synthase 2	Mus musculus	6-22
18455806-2	2008	Among cyclooxygenase-2 (COX-2) knockout mice the behavioural, corticosterone and cytokine variations promoted by LPS were moderately (home cage activity, corticosterone, TNF-alpha) or largely (IL-6) reduced.	Corticosterone	154-168	prostaglandin-endoperoxide synthase 2	Mus musculus	24-29
18455806-2	2008	Among cyclooxygenase-2 (COX-2) knockout mice the behavioural, corticosterone and cytokine variations promoted by LPS were moderately (home cage activity, corticosterone, TNF-alpha) or largely (IL-6) reduced.	Corticosterone	154-168	toll-like receptor 4	Mus musculus	113-116
18455806-3	2008	However, if mice were exposed to a psychosocial stressor (social disruption associated with grouping mice with novel cage-mates after a period of isolation) coupled with LPS treatment, then the effects of the COX-2 deletion were absent, or there was a synergistic or additive elevation apparent (e.g., in the case of TNF-alpha, IL-6 and corticosterone).	Corticosterone	337-351	toll-like receptor 4	Mus musculus	170-173
18547442-0	2008	Mechanism of nuclear factor of activated T-cells mediated FasL expression in corticosterone -treated mouse Leydig tumor cells.	Corticosterone	77-91	Fas ligand (TNF superfamily, member 6)	Mus musculus	58-62
18547442-2	2008	We have previously reported that the stress levels of corticosterone (CORT, glucocorticoid in rat) increase expression of Fas/FasL and activate Fas/FasL signal pathway in rat Leydig cells, which consequently leads to apoptosis.	Corticosterone	54-68	cortistatin	Rattus norvegicus	70-74
18547442-2	2008	We have previously reported that the stress levels of corticosterone (CORT, glucocorticoid in rat) increase expression of Fas/FasL and activate Fas/FasL signal pathway in rat Leydig cells, which consequently leads to apoptosis.	Corticosterone	54-68	Fas ligand	Rattus norvegicus	126-130
18547442-2	2008	We have previously reported that the stress levels of corticosterone (CORT, glucocorticoid in rat) increase expression of Fas/FasL and activate Fas/FasL signal pathway in rat Leydig cells, which consequently leads to apoptosis.	Corticosterone	54-68	Fas ligand	Rattus norvegicus	148-152
18423439-7	2008	These results suggest that centrally administered corticotrophin-releasing factor elevates plasma corticosterone by the corticotropin-releasing factor 1 receptor and alpha(3) subunit-containing nicotinic acetylcholine receptor (probably alpha(3)beta(2) nicotinic acetylcholine receptor) mediated activation of the locus coeruleus noradrenergic neurons projecting to the paraventricular nucleus in rats.	Corticosterone	98-112	corticotropin releasing hormone	Rattus norvegicus	120-150
18423439-7	2008	These results suggest that centrally administered corticotrophin-releasing factor elevates plasma corticosterone by the corticotropin-releasing factor 1 receptor and alpha(3) subunit-containing nicotinic acetylcholine receptor (probably alpha(3)beta(2) nicotinic acetylcholine receptor) mediated activation of the locus coeruleus noradrenergic neurons projecting to the paraventricular nucleus in rats.	Corticosterone	98-112	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	194-226
18423439-7	2008	These results suggest that centrally administered corticotrophin-releasing factor elevates plasma corticosterone by the corticotropin-releasing factor 1 receptor and alpha(3) subunit-containing nicotinic acetylcholine receptor (probably alpha(3)beta(2) nicotinic acetylcholine receptor) mediated activation of the locus coeruleus noradrenergic neurons projecting to the paraventricular nucleus in rats.	Corticosterone	98-112	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	253-285
18485334-6	2008	In the hippocampus, a single corticosterone dose (10 mg/kg, s.c.) caused a widespread and transient reduction of fosB mRNA after 0.8 h, whereas changes in both c-fos and fra-1 mRNA levels were restricted to the dentate gyrus region.	Corticosterone	29-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-165
18485334-6	2008	In the hippocampus, a single corticosterone dose (10 mg/kg, s.c.) caused a widespread and transient reduction of fosB mRNA after 0.8 h, whereas changes in both c-fos and fra-1 mRNA levels were restricted to the dentate gyrus region.	Corticosterone	29-43	FOS like 1, AP-1 transcription factor subunit	Rattus norvegicus	170-175
18485334-7	2008	Corticosterone treatment gave rise to a delayed and significant reduction of junB mRNA signals after 2 h in all hippocampal regions, which reversed to increase at 4 h. c-jun and egr-1 mRNA levels were unaffected by corticosterone treatment.	Corticosterone	0-14	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	77-81
18485334-7	2008	Corticosterone treatment gave rise to a delayed and significant reduction of junB mRNA signals after 2 h in all hippocampal regions, which reversed to increase at 4 h. c-jun and egr-1 mRNA levels were unaffected by corticosterone treatment.	Corticosterone	0-14	early growth response 1	Rattus norvegicus	178-183
18407357-8	2008	Similarly, TNFalpha was only modestly elevated under repeated SEA conditions that elevated plasma corticosterone.	Corticosterone	98-112	tumor necrosis factor	Mus musculus	11-19
18637557-2	2008	ACTH stimulated corticosterone output in the breeding season.	Corticosterone	16-30	proopiomelanocortin	Homo sapiens	0-4
18520055-4	2008	The response of ACTH and/or PRL on corticosterone and progesterone release was higher in the pantothenic acid-treated rats than in the control rats.	Corticosterone	35-49	prolactin	Rattus norvegicus	28-31
18520055-5	2008	In addition, PRL increased the stimulatory effect of ACTH-induced corticosterone secretion in both normal and pantothenic acid-treated rats.	Corticosterone	66-80	prolactin	Rattus norvegicus	13-16
18601688-3	2008	FRET analysis revealed that steroid treatment (with corticosterone or testosterone) induces direct interaction of the glucocorticoid receptor (GR) and importin alpha in the cytoplasm and that, shortly after nuclear entry, the GR detaches from importin alpha.	Corticosterone	52-66	nuclear receptor subfamily 3 group C member 1	Homo sapiens	118-141
18601688-3	2008	FRET analysis revealed that steroid treatment (with corticosterone or testosterone) induces direct interaction of the glucocorticoid receptor (GR) and importin alpha in the cytoplasm and that, shortly after nuclear entry, the GR detaches from importin alpha.	Corticosterone	52-66	nuclear receptor subfamily 3 group C member 1	Homo sapiens	143-145
18601688-3	2008	FRET analysis revealed that steroid treatment (with corticosterone or testosterone) induces direct interaction of the glucocorticoid receptor (GR) and importin alpha in the cytoplasm and that, shortly after nuclear entry, the GR detaches from importin alpha.	Corticosterone	52-66	nuclear receptor subfamily 3 group C member 1	Homo sapiens	226-228
18622051-15	2008	Dihydropyridine, nifedipine, a specific L-type Ca(2+) channel blocker, inhibited significantly the CRH-induced ACTH and corticosterone response in rats exposed to 3 days crowding stress but not in rats under basal conditions.	Corticosterone	120-134	corticotropin releasing hormone	Rattus norvegicus	99-102
17700644-7	2008	Consistent with anxiogenic-like behavior, PDE4B-/- mice displayed increased levels of plasma corticosterone.	Corticosterone	93-107	phosphodiesterase 4B, cAMP specific	Mus musculus	42-47
17805310-9	2008	PCAF KO mice also showed an exaggerated response to acute stress, forced swimming, and conditioned fear, associated with increased plasma corticosterone levels.	Corticosterone	138-152	K(lysine) acetyltransferase 2B	Mus musculus	0-4
18513404-7	2008	RESULTS: MA increased corticosterone from 1-72 h with a peak 1 h after the first treatment, whereas glucose was only increased 1 h post-treatment.	Corticosterone	22-36	pseudopodium-enriched atypical kinase 1	Rattus norvegicus	56-62
18321654-5	2008	These results show that high corticosterone release facilitates hippocampal CA1 mGluR-dependent LTD, and does so through local GRs.	Corticosterone	29-43	carbonic anhydrase 1	Rattus norvegicus	76-79
18378095-8	2008	Chronic stress exposure facilitated plasma corticosterone responses to the novel restraint stress and elevated CRH mRNA.	Corticosterone	43-57	corticotropin releasing hormone	Rattus norvegicus	111-114
18308401-9	2008	Application of the glucocorticoid receptor antagonist RU38486 (200 mg/kg) elevated plasma corticosterone for at least 8h.	Corticosterone	90-104	nuclear receptor subfamily 3, group C, member 1	Mus musculus	19-42
18403117-3	2008	We found that NP mRNA expression was dramatically increased shortly after exposure to the acute restraint tail-shock stress and remained at high level for at least 24 h. The level of NP mRNA would be correlated to the elevated plasma concentration of the glucocorticoid corticosterone (CORT) and to the stress intensity.	Corticosterone	270-284	opsin 5	Mus musculus	14-16
18403117-3	2008	We found that NP mRNA expression was dramatically increased shortly after exposure to the acute restraint tail-shock stress and remained at high level for at least 24 h. The level of NP mRNA would be correlated to the elevated plasma concentration of the glucocorticoid corticosterone (CORT) and to the stress intensity.	Corticosterone	270-284	opsin 5	Mus musculus	183-185
18287218-2	2008	However, suppression of cell proliferation in rats by the platform-over-water SD method has been attributed to elevated corticosterone (Cort), a potent inhibitor of cell proliferation and nonspecific correlate of this procedure.	Corticosterone	120-134	cortistatin	Rattus norvegicus	136-140
18218695-3	2008	Adrenalectomized, corticosterone-clamped animals showed no significant rise in corticosterone after LPS, compared with saline-treated controls but increased IL-6 levels and tanycyte D2 mRNA similar to LPS-treated sham controls.	Corticosterone	18-32	interleukin 6	Rattus norvegicus	157-161
18379123-3	2008	In this study we examined the effects of various doses (10 (-12) -10 (-7) M) of corticosterone on GH and PRL production in a rat pituitary somatomammotropic cell line, MtT/SM cells, and found that GH mRNA expression was facilitated by high doses (10 (-7) and 10 (-8) M).	Corticosterone	80-94	gonadotropin releasing hormone receptor	Rattus norvegicus	98-100
18379123-3	2008	In this study we examined the effects of various doses (10 (-12) -10 (-7) M) of corticosterone on GH and PRL production in a rat pituitary somatomammotropic cell line, MtT/SM cells, and found that GH mRNA expression was facilitated by high doses (10 (-7) and 10 (-8) M).	Corticosterone	80-94	prolactin	Rattus norvegicus	105-108
18379123-3	2008	In this study we examined the effects of various doses (10 (-12) -10 (-7) M) of corticosterone on GH and PRL production in a rat pituitary somatomammotropic cell line, MtT/SM cells, and found that GH mRNA expression was facilitated by high doses (10 (-7) and 10 (-8) M).	Corticosterone	80-94	gonadotropin releasing hormone receptor	Rattus norvegicus	197-199
18379123-4	2008	In contrast, a biphasic effect of corticosterone on PRL mRNA expression and secretion was observed, i.e., high doses (10 (-7) and 10 (-8) M) suppressed and low doses (10 (-12) -10 (-10) M) facilitated them.	Corticosterone	34-48	prolactin	Rattus norvegicus	52-55
18379123-5	2008	In an immunofluorescent staining study, the number of PRL immunopositive cells increased with low doses of corticosterone while it decreased with high doses of it, which corresponded to PRL mRNA expression and hormone secretion, respectively.	Corticosterone	107-121	prolactin	Rattus norvegicus	54-57
18379123-6	2008	These effects of corticosterone on PRL production were abolished by a glucocorticoid receptor (GR) antagonist, mifepristone.	Corticosterone	17-31	prolactin	Rattus norvegicus	35-38
18547240-2	2008	The increased expression of brain-derived neurotrophic factor (BDNF) and trkB mRNA in the dentate gyrus which otherwise occurred after L-NAME was also prevented by clamping the corticoid rhythm in adrenalectomized rats, but was restored by daily additional injections of corticosterone (which replicates the diurnal rhythm).	Corticosterone	271-285	brain-derived neurotrophic factor	Rattus norvegicus	28-61
18379123-7	2008	In addition, co-treatment with low doses of corticosterone (10 (-12) -10 (-10) M) and 17beta-estradiol (E(2), 10 nM) additively increased the number of PRL immunopositive cells.	Corticosterone	44-58	prolactin	Rattus norvegicus	152-155
18379123-8	2008	Moreover, a 24 h BrdU incorporation experiment suggested that the increase in the number of PRL immunopositive cells treated with low dose corticosterone was caused by novel synthesis of PRL while, on the other hand, that of those treated with E(2) resulted from PRL cell proliferation.	Corticosterone	139-153	prolactin	Rattus norvegicus	92-95
18379123-8	2008	Moreover, a 24 h BrdU incorporation experiment suggested that the increase in the number of PRL immunopositive cells treated with low dose corticosterone was caused by novel synthesis of PRL while, on the other hand, that of those treated with E(2) resulted from PRL cell proliferation.	Corticosterone	139-153	prolactin	Rattus norvegicus	187-190
18379123-8	2008	Moreover, a 24 h BrdU incorporation experiment suggested that the increase in the number of PRL immunopositive cells treated with low dose corticosterone was caused by novel synthesis of PRL while, on the other hand, that of those treated with E(2) resulted from PRL cell proliferation.	Corticosterone	139-153	prolactin	Rattus norvegicus	187-190
18379123-9	2008	Thus, we concluded that corticosterone biphasically regulates PRL production and the sensitivity of E(2) to different degrees.	Corticosterone	24-38	prolactin	Rattus norvegicus	62-65
18202128-5	2008	Treatment with corticosterone (CORT) decreased, whereas the corticosteroid synthesis inhibitor metyrapone increased CRF expression in the anterior preoptic area (homolog of the mammalian paraventricular nucleus), as measured by CRF primary transcript, mRNA, and CRF immunoreactivity (ir) (by immunocytochemistry).	Corticosterone	15-29	cortistatin	Homo sapiens	31-35
18547240-2	2008	The increased expression of brain-derived neurotrophic factor (BDNF) and trkB mRNA in the dentate gyrus which otherwise occurred after L-NAME was also prevented by clamping the corticoid rhythm in adrenalectomized rats, but was restored by daily additional injections of corticosterone (which replicates the diurnal rhythm).	Corticosterone	271-285	brain-derived neurotrophic factor	Rattus norvegicus	63-67
18547240-2	2008	The increased expression of brain-derived neurotrophic factor (BDNF) and trkB mRNA in the dentate gyrus which otherwise occurred after L-NAME was also prevented by clamping the corticoid rhythm in adrenalectomized rats, but was restored by daily additional injections of corticosterone (which replicates the diurnal rhythm).	Corticosterone	271-285	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	73-77
18547240-3	2008	Unilateral infusions of BDNF into the lateral ventricle increased proliferation in the dentate gyrus on the side of the infusion, but this was not observed following implantation of subcutaneous corticosterone, which flattened the diurnal corticosterone rhythm.	Corticosterone	239-253	brain-derived neurotrophic factor	Rattus norvegicus	24-28
18547240-4	2008	5HT1A mRNA in the dentate gyrus was increased on both sides of the brain by unilateral BDNF infusions, but this was also prevented by subcutaneous corticosterone pellets.	Corticosterone	147-161	5-hydroxytryptamine receptor 1A	Rattus norvegicus	0-5
18547240-5	2008	These results show that the diurnal rhythm of corticosterone regulates the stimulating action of NOS inhibitors on BDNF as well as on neurogenesis in the dentate gyrus, and that BDNF becomes ineffective on both proliferation rates and 5HT1A expression in the absence of a rhythm in corticosterone.	Corticosterone	46-60	brain-derived neurotrophic factor	Rattus norvegicus	115-119
18547242-1	2008	Corticosterone (100 nm) rapidly increases the frequency of miniature excitatory postsynaptic currents in mouse CA1 pyramidal neurons via membrane-located mineralocorticoid receptors (MRs).	Corticosterone	0-14	carbonic anhydrase 1	Mus musculus	111-114
18547242-7	2008	Through these dual pathways, high corticosterone concentrations such as occur after stress could contribute to enhanced CA1 pyramidal excitability.	Corticosterone	34-48	carbonic anhydrase 1	Mus musculus	120-123
18347231-3	2008	We investigated the effects of corticosterone (10(-6) to 10(-12) mol/L) on early vascular mineralocorticoid receptor signaling by Western blotting, confocal microscopy, and myography.	Corticosterone	31-45	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	90-116
18347231-4	2008	Corticosterone initiated extracellular signal-regulated kinase 1/2 phosphorylation in rat vascular smooth muscle cells at &gt; or =10(-11) mol/L doses.	Corticosterone	0-14	mitogen activated protein kinase 3	Rattus norvegicus	25-64
18347231-6	2008	Corticosterone also stimulated c-Jun N-terminal kinase, p38, Src, and Akt phosphorylation at 15 minutes and enhanced angiotensin II-induced signaling at 5 minutes.	Corticosterone	0-14	mitogen activated protein kinase 14	Rattus norvegicus	56-59
18347231-6	2008	Corticosterone also stimulated c-Jun N-terminal kinase, p38, Src, and Akt phosphorylation at 15 minutes and enhanced angiotensin II-induced signaling at 5 minutes.	Corticosterone	0-14	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	61-64
18347231-6	2008	Corticosterone also stimulated c-Jun N-terminal kinase, p38, Src, and Akt phosphorylation at 15 minutes and enhanced angiotensin II-induced signaling at 5 minutes.	Corticosterone	0-14	AKT serine/threonine kinase 1	Rattus norvegicus	70-73
18347231-6	2008	Corticosterone also stimulated c-Jun N-terminal kinase, p38, Src, and Akt phosphorylation at 15 minutes and enhanced angiotensin II-induced signaling at 5 minutes.	Corticosterone	0-14	angiotensinogen	Rattus norvegicus	117-131
18347231-7	2008	A specific epidermal growth factor receptor blocker, AG1478, as well as the Src inhibitor PP2, markedly reduced corticosterone-induced extracellular signal-regulated kinase 1/2 phosphorylation, as did preincubation of cells with the mineralocorticoid receptor antagonist spironolactone.	Corticosterone	112-126	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	76-79
18347231-7	2008	A specific epidermal growth factor receptor blocker, AG1478, as well as the Src inhibitor PP2, markedly reduced corticosterone-induced extracellular signal-regulated kinase 1/2 phosphorylation, as did preincubation of cells with the mineralocorticoid receptor antagonist spironolactone.	Corticosterone	112-126	mitogen activated protein kinase 3	Rattus norvegicus	135-176
18347231-7	2008	A specific epidermal growth factor receptor blocker, AG1478, as well as the Src inhibitor PP2, markedly reduced corticosterone-induced extracellular signal-regulated kinase 1/2 phosphorylation, as did preincubation of cells with the mineralocorticoid receptor antagonist spironolactone.	Corticosterone	112-126	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	233-259
18347231-8	2008	Silencing mineralocorticoid receptor with small interfering RNA abolished corticosterone-induced effects.	Corticosterone	74-88	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	10-36
18347231-11	2008	We conclude that corticosterone induces rapid mineralocorticoid receptor signaling in vascular smooth muscle cells that involves mitogen-activated protein kinase kinase/extracellular signal-regulated kinase-dependent pathways.	Corticosterone	17-31	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	46-72
18434350-7	2008	A comparison between conventional end point assays and real-time measurement showed similar effects for dexamethasone and hydrocortisone, with a less effective inhibition of IL-6 seen with corticosterone.	Corticosterone	189-203	interleukin 6	Homo sapiens	174-178
18434352-9	2008	A mineralocorticoid receptor (MR) antagonist spironolactone, co-administered with corticosterone, further depressed [Ca2+]i responses to glucose, while an MR ligand aldosterone attenuated the corticosterone inhibition of [Ca2+]i responses.	Corticosterone	82-96	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	2-28
18434352-9	2008	A mineralocorticoid receptor (MR) antagonist spironolactone, co-administered with corticosterone, further depressed [Ca2+]i responses to glucose, while an MR ligand aldosterone attenuated the corticosterone inhibition of [Ca2+]i responses.	Corticosterone	82-96	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	30-32
18434352-9	2008	A mineralocorticoid receptor (MR) antagonist spironolactone, co-administered with corticosterone, further depressed [Ca2+]i responses to glucose, while an MR ligand aldosterone attenuated the corticosterone inhibition of [Ca2+]i responses.	Corticosterone	192-206	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	2-28
18434352-9	2008	A mineralocorticoid receptor (MR) antagonist spironolactone, co-administered with corticosterone, further depressed [Ca2+]i responses to glucose, while an MR ligand aldosterone attenuated the corticosterone inhibition of [Ca2+]i responses.	Corticosterone	192-206	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	30-32
18434352-9	2008	A mineralocorticoid receptor (MR) antagonist spironolactone, co-administered with corticosterone, further depressed [Ca2+]i responses to glucose, while an MR ligand aldosterone attenuated the corticosterone inhibition of [Ca2+]i responses.	Corticosterone	192-206	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	155-157
18434352-12	2008	This effect is mediated by GR and attenuated partially by simultaneous MR stimulation by corticosterone.	Corticosterone	89-103	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	71-73
18180766-8	2008	Moreover, competent endothelial cells for the gene encoding Toll-like receptor 4 (TLR4) are essential for the release of plasma corticosterone in response to low and high doses of lipopolysaccharide.	Corticosterone	128-142	toll-like receptor 4	Mus musculus	60-80
18187395-2	2008	Interconversion of corticosterone (CORT), the active form in rodents, and 11-dehydroCORT, the biologically inert 11-keto form, is catalyzed by 11betaHSD1.	Corticosterone	19-33	cortistatin	Rattus norvegicus	35-39
18187395-2	2008	Interconversion of corticosterone (CORT), the active form in rodents, and 11-dehydroCORT, the biologically inert 11-keto form, is catalyzed by 11betaHSD1.	Corticosterone	19-33	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	143-153
18363802-8	2008	Plasma corticosterone concentrations were reduced in Avpr1b knockout mice in response to change in environment but not to mild restraint or forced swim stress.	Corticosterone	7-21	arginine vasopressin receptor 1B	Mus musculus	53-59
18363802-11	2008	Furthermore, the normal corticosterone response to repeated exposure to change in environment stress also requires the Avpr1b to drive HPA axis responsiveness.	Corticosterone	24-38	arginine vasopressin receptor 1B	Mus musculus	119-125
18180766-8	2008	Moreover, competent endothelial cells for the gene encoding Toll-like receptor 4 (TLR4) are essential for the release of plasma corticosterone in response to low and high doses of lipopolysaccharide.	Corticosterone	128-142	toll-like receptor 4	Mus musculus	82-86
18280051-9	2008	In wild-type and beta-endorphin-deficient mice, corticosterone levels returned to baseline within 60min after stress exposure.	Corticosterone	48-62	pro-opiomelanocortin-alpha	Mus musculus	17-31
18064482-3	2008	In a pituitary culture experiment with E11 embryos, both corticosterone and aldosterone stimulated GH mRNA expression and increased the number of GH cells in both lobes of the pituitary gland in a dose-dependent manner.	Corticosterone	57-71	growth hormone	Gallus gallus	99-101
18339373-4	2008	While the mineralocorticoid receptor remains activated throughout the ultradian cycle, the glucocorticoid receptor shows a phasic response to each individual pulse of corticosterone.	Corticosterone	167-181	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	91-114
17883406-8	2008	Comparable increase in plasma corticosterone of Mgat5(+/+) and Mgat5(-/-) mice in response to acute stress shows an intact function of the hypothalamus-pituitary-adrenal axis.	Corticosterone	30-44	mannoside acetylglucosaminyltransferase 5	Mus musculus	48-53
18047561-4	2008	In the present study, CB1 knockout mice exhibited an augmented response to stress revealed by the increased despair behavior and corticosterone levels showed in the tail suspension test and decreased brain derived neurotrophic factor (BDNF) levels in the hippocampus.	Corticosterone	129-143	cannabinoid receptor 1 (brain)	Mus musculus	22-25
17662459-8	2008	Consistent with this, ERbeta-selective agonists also inhibited the ACTH and corticosterone response to stress.	Corticosterone	76-90	estrogen receptor 2	Rattus norvegicus	22-28
18177641-9	2008	However, GLP-1 enhanced CVS-induced facilitation of corticosterone (but not ACTH) response to an acute stress, whereas dHG-exendin inhibited facilitation.	Corticosterone	52-66	glucagon	Rattus norvegicus	9-14
17849416-0	2008	Corticosterone induces steroidogenic lesion in cultured adult rat Leydig cells by reducing the expression of star protein and steroidogenic enzymes.	Corticosterone	0-14	steroidogenic acute regulatory protein	Rattus norvegicus	109-113
17849416-7	2008	StAR protein gene expression was significantly inhibited by higher doses of corticosterone employed.	Corticosterone	76-90	steroidogenic acute regulatory protein	Rattus norvegicus	0-4
18373481-5	2008	Tail vein blood was analyzed for corticosterone (CORT) content by radioimmunoassay.	Corticosterone	33-47	cortistatin	Rattus norvegicus	49-53
17963039-2	2008	By converting intrinsically inert glucocorticoids (cortisone, 11-dehydrocorticosterone) into their active forms (cortisol, corticosterone), 11beta-HSD1 increases glucocorticoid access to receptors.	Corticosterone	72-86	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	140-151
18064482-3	2008	In a pituitary culture experiment with E11 embryos, both corticosterone and aldosterone stimulated GH mRNA expression and increased the number of GH cells in both lobes of the pituitary gland in a dose-dependent manner.	Corticosterone	57-71	growth hormone	Gallus gallus	146-148
18064482-5	2008	Interestingly, an in vitro serum-free culture experiment with an E11 pituitary gland showed that the GH mRNA level spontaneously increased during cultivation for 2 days without any extra stimulation, and this increase in GH mRNA level was completely suppressed by metyrapone, a corticosterone-producing enzyme P450C11 inhibitor.	Corticosterone	278-292	growth hormone	Gallus gallus	101-103
18064482-5	2008	Interestingly, an in vitro serum-free culture experiment with an E11 pituitary gland showed that the GH mRNA level spontaneously increased during cultivation for 2 days without any extra stimulation, and this increase in GH mRNA level was completely suppressed by metyrapone, a corticosterone-producing enzyme P450C11 inhibitor.	Corticosterone	278-292	growth hormone	Gallus gallus	221-223
18064482-6	2008	Moreover, progesterone, the corticosterone precursor, also stimulated GH mRNA expression in the cultured chicken pituitary gland, and this effect was blocked by pretreatment with metyrapone.	Corticosterone	28-42	growth hormone	Gallus gallus	70-72
18311602-0	2008	Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study.	Corticosterone	82-96	phosphatidylethanolamine binding protein 1	Rattus norvegicus	17-59
18311602-0	2008	Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study.	Corticosterone	82-96	phosphatidylethanolamine binding protein 1	Rattus norvegicus	61-66
18311602-2	2008	This study investigates how long-lasting administration of corticosterone as a mimic of experimentally induced stress affects psychometric performance and the expression of the phosphatidylethanolamine binding protein (PEBP1) in the adult hippocampus of one-year-old male rats.	Corticosterone	59-73	phosphatidylethanolamine binding protein 1	Rattus norvegicus	219-224
18311602-8	2008	Results show that chronic corticosterone significantly decreased rat hippocampal PEBP1 expression and induced a working and reference memory dysfunction.	Corticosterone	26-40	phosphatidylethanolamine binding protein 1	Rattus norvegicus	81-86
18311602-9	2008	From this, we derive the preliminary hypothesis that PEBP1 may be a novel molecular mediator influencing cognitive integrity during chronic corticosterone exposure in rat hippocampus.	Corticosterone	140-154	phosphatidylethanolamine binding protein 1	Rattus norvegicus	53-58
18191822-0	2008	Systemic administration of leptin decreases plasma corticosterone levels: role of hypothalamic norepinephrine.	Corticosterone	51-65	leptin	Rattus norvegicus	27-33
18191822-12	2008	Administration of either PHE or CLON in combination with leptin prevented the leptin-induced decrease in CS.	Corticosterone	105-107	leptin	Rattus norvegicus	57-63
18191822-12	2008	Administration of either PHE or CLON in combination with leptin prevented the leptin-induced decrease in CS.	Corticosterone	105-107	leptin	Rattus norvegicus	78-84
18073273-5	2008	Silencing of 11beta-HSD1 substantially attenuated the accumulation of lipid droplets and the expression of adipogenesis marker genes, which was induced by a mixture containing either corticosterone or dexamethasone.	Corticosterone	183-197	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	13-24
18073273-6	2008	Silencing of 11beta-HSD1 increased the concentration of 11-dehydrocorticosterone in the culture supernatant but did not significantly affect the levels of corticosterone or dexamethasone.	Corticosterone	66-80	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	13-24
17889834-5	2008	RESULTS: Chronic corticosterone (CORT) increased immobility, decreased responding in an operant conditioning task of motivation, and selectively reduced phosphorylated ERK1/2 (pERK1/2) in the dentate gyrus.	Corticosterone	17-31	cortistatin	Homo sapiens	33-37
17889834-5	2008	RESULTS: Chronic corticosterone (CORT) increased immobility, decreased responding in an operant conditioning task of motivation, and selectively reduced phosphorylated ERK1/2 (pERK1/2) in the dentate gyrus.	Corticosterone	17-31	mitogen-activated protein kinase 3	Homo sapiens	168-174
17889834-7	2008	Corticosterone regulated pERK1/2 on a time course that paralleled increases in heat shock proteins associated with depression and decreased tyrosine kinase receptor B (trkB) phosphorylation.	Corticosterone	0-14	neurotrophic receptor tyrosine kinase 2	Homo sapiens	140-166
17889834-7	2008	Corticosterone regulated pERK1/2 on a time course that paralleled increases in heat shock proteins associated with depression and decreased tyrosine kinase receptor B (trkB) phosphorylation.	Corticosterone	0-14	neurotrophic receptor tyrosine kinase 2	Homo sapiens	168-172
18006628-5	2008	We show that the concentration of glucocorticoid receptor and the type of ligand, i.e. corticosterone or dexamethasone, determines the repression.	Corticosterone	87-101	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	34-57
18279365-0	2008	Opposite actions of hypothalamic vasopressin on circadian corticosterone rhythm in nocturnal versus diurnal species.	Corticosterone	58-72	arginine vasopressin	Homo sapiens	33-44
18279365-4	2008	Previously, we showed that, in the rat, vasopressin (VP) derived from the SCN has a strong inhibitory effect on the release of adrenal corticosterone and is an important component in the generation of a daily rhythm in plasma corticosterone concentrations.	Corticosterone	135-149	arginine vasopressin	Rattus norvegicus	40-51
18279365-4	2008	Previously, we showed that, in the rat, vasopressin (VP) derived from the SCN has a strong inhibitory effect on the release of adrenal corticosterone and is an important component in the generation of a daily rhythm in plasma corticosterone concentrations.	Corticosterone	135-149	arginine vasopressin	Rattus norvegicus	53-55
18279365-4	2008	Previously, we showed that, in the rat, vasopressin (VP) derived from the SCN has a strong inhibitory effect on the release of adrenal corticosterone and is an important component in the generation of a daily rhythm in plasma corticosterone concentrations.	Corticosterone	226-240	arginine vasopressin	Rattus norvegicus	40-51
18279365-4	2008	Previously, we showed that, in the rat, vasopressin (VP) derived from the SCN has a strong inhibitory effect on the release of adrenal corticosterone and is an important component in the generation of a daily rhythm in plasma corticosterone concentrations.	Corticosterone	226-240	arginine vasopressin	Rattus norvegicus	53-55
18279365-5	2008	In the present study we investigated the role of VP in the control of the daily corticosterone rhythm in a diurnal rodent, i.e. Arvicanthis ansorgei.	Corticosterone	80-94	arginine vasopressin	Homo sapiens	49-51
18279365-6	2008	Contrary to our previous (rat) results, VP administered to the hypothalamic paraventricular nucleus in A. ansorgei had a stimulatory effect on the release of corticosterone.	Corticosterone	158-172	arginine vasopressin	Rattus norvegicus	40-42
17936761-0	2008	Sex differences in plasma corticosterone release in undisturbed chickens (Gallus gallus) in response to arginine vasotocin and corticotropin releasing hormone.	Corticosterone	26-40	corticotropin releasing hormone	Gallus gallus	127-158
18252955-0	2008	Effect of the glucocorticoid receptor antagonist Org 34850 on fast and delayed feedback of corticosterone release.	Corticosterone	91-105	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	14-37
18252955-1	2008	We investigated the effect of the glucocorticoid receptor (GR) antagonist Org 34850 on fast and delayed inhibition of corticosterone secretion in response to the synthetic glucocorticoid methylprednisolone (MPL).	Corticosterone	118-132	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	59-61
18252955-8	2008	However, blockade of GR with Org 34850 prevented delayed inhibition of MPL on corticosterone secretion measured between 4 and 12 h after MPL administration.	Corticosterone	78-92	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	21-23
18252955-9	2008	Our data suggest an involvement of GR in modulating delayed, but not fast, inhibition induced by MPL on basal corticosterone secretion.	Corticosterone	110-124	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	35-37
18077660-1	2008	The stress hormone corticosterone increases the amplitude of the slow afterhyperpolarization (sAHP) in CA1 pyramidal neurons, without affecting resting membrane potential, input resistance, or action potential characteristics.	Corticosterone	19-33	carbonic anhydrase 1	Homo sapiens	103-106
18077660-6	2008	In situ hybridization studies revealed that CA1 cells express Cav1.2 and Cav1.3 subunits; corticosterone does not transcriptionally regulate Cav1.2 but increases Cav1.3 expression compared with vehicle treatment.	Corticosterone	90-104	calcium voltage-gated channel subunit alpha1 D	Homo sapiens	162-168
18077660-9	2008	In a modeling study, we examined putative consequences of changes in specific calcium channel subunit expression and calcium extrusion by corticosterone for the AHP in CA1 and amygdala neurons.	Corticosterone	138-152	carbonic anhydrase 1	Homo sapiens	168-171
18088360-4	2008	beta-MSH injection on food and water intake, plasma corticosterone concentration, ingestive and non-ingestive behaviours, and hypothalamic neuronal activation using Cobb-500 chicks.	Corticosterone	52-66	proopiomelanocortin	Homo sapiens	0-8
18088360-6	2008	beta-MSH-treated chicks also had increased plasma corticosterone concentrations and increased c-Fos reactivity in the periventricular, paraventricular and infundibular nuclei, and the ventromedial hypothalamus; however, the lateral hypothalamus was not affected.	Corticosterone	50-64	proopiomelanocortin	Homo sapiens	0-8
18079066-7	2008	Compared to a saline injection, TRH reduced cumulative burying, and decreased serum corticosterone levels, supporting anxiolytic-like effects of TRH administration.	Corticosterone	84-98	thyrotropin releasing hormone	Rattus norvegicus	32-35
18308097-9	2008	CONCLUSIONS: Our results suggest reduced activity of CYP21A2 (P450c21), the enzyme that converts progesterone to corticosterone and 17-hydroxyprogesterone to 11-deoxycortisol.	Corticosterone	113-127	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	53-60
18086466-2	2008	In previous papers we have demonstrated that corticosterone increases FGF-2 immunoreactivity mainly in the astrocytes of the substantia nigra [Chadi, G., Rosen, L., Cintra, A., Tinner, B., Zoli, M., Pettersson, R.F., Fuxe, K., 1993b.	Corticosterone	45-59	fibroblast growth factor 2	Rattus norvegicus	70-75
18086466-3	2008	Corticosterone increases FGF-2 (bFGF) immunoreactivity in the substantia nigra of the rat.	Corticosterone	0-14	fibroblast growth factor 2	Rattus norvegicus	25-30
18086466-3	2008	Corticosterone increases FGF-2 (bFGF) immunoreactivity in the substantia nigra of the rat.	Corticosterone	0-14	fibroblast growth factor 2	Rattus norvegicus	32-36
18230901-6	2008	The enzyme that mediates this activation, conversion of cortisone (11-dehydrocorticosterone in rodents) to cortisol (corticosterone in rodents), locally within tissues is 11beta -hydroxysteroid dehydrogenase type 1 (11beta -HSD1).	Corticosterone	77-91	RNA, U1 small nuclear 1	Homo sapiens	224-228
17708551-8	2008	All effects of acute corticosterone administration could be prevented by the glucocorticoid receptor antagonist RU38486 given during the last 4 days of the stress or handling protocol.	Corticosterone	21-35	nuclear receptor subfamily 3 group C member 1	Homo sapiens	77-100
17708551-9	2008	We conclude that brief exposure to high concentrations of corticosterone can differently affect apical dendritic structure, depending on the earlier history of the animal, a process that critically depends on involvement of the glucocorticoid receptor.	Corticosterone	58-72	nuclear receptor subfamily 3 group C member 1	Homo sapiens	228-251
18398848-3	2008	In the present study, we examined the combined long-term effect of an early stress, in the form of maternal deprivation, and a later stress, simulated by chronic young-adult treatment with the stress hormone, corticosterone, on BDNF expression in the hippocampus of rats.	Corticosterone	209-223	brain-derived neurotrophic factor	Rattus norvegicus	228-232
18398848-7	2008	Rats which had undergone both maternal deprivation and corticosterone treatment displayed a unique and significant 25-35% reduction of BDNF expression in the dentate gyrus (DG), and similar trends in the CA1 and CA3 regions of the hippocampus.	Corticosterone	55-69	brain-derived neurotrophic factor	Rattus norvegicus	135-139
18398848-7	2008	Rats which had undergone both maternal deprivation and corticosterone treatment displayed a unique and significant 25-35% reduction of BDNF expression in the dentate gyrus (DG), and similar trends in the CA1 and CA3 regions of the hippocampus.	Corticosterone	55-69	carbonic anhydrase 1	Rattus norvegicus	204-207
18398848-7	2008	Rats which had undergone both maternal deprivation and corticosterone treatment displayed a unique and significant 25-35% reduction of BDNF expression in the dentate gyrus (DG), and similar trends in the CA1 and CA3 regions of the hippocampus.	Corticosterone	55-69	carbonic anhydrase 3	Rattus norvegicus	212-215
18064300-7	2008	Furthermore, corticosterone supplementation decreased the sensitivity of SR-BI-null mice to LPS.	Corticosterone	13-27	scavenger receptor class B, member 1	Mus musculus	73-78
18097062-6	2008	The lungs of pups genetically deficient in MIF were less mature upon histological evaluation, and demonstrated lower levels of vascular endothelial growth factor and corticosterone--two factors that promote fetal lung maturation.	Corticosterone	166-180	macrophage migration inhibitory factor	Homo sapiens	43-46
17909224-3	2008	MR induced 11beta-HSD1 activity in all ATs, correlating with increased tissue corticosterone.	Corticosterone	78-92	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	11-22
17703894-5	2008	Deletion of TREK-1 in mice caused a substantially reduced elevation of corticosterone levels under stress, and produced behaviour similar to that of naive animals treated with fluoxetine in various behavioural tests.	Corticosterone	71-85	potassium channel, subfamily K, member 2	Mus musculus	12-18
18679014-0	2008	The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.	Corticosterone	72-86	peptidase inhibitor 3	Homo sapiens	12-15
18679014-0	2008	The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.	Corticosterone	72-86	AKT serine/threonine kinase 1	Homo sapiens	16-19
18679014-0	2008	The role of PI3/Akt pathway in the protective effect of insulin against corticosterone cell death induction in hippocampal cell culture.	Corticosterone	72-86	insulin	Homo sapiens	56-63
18679014-6	2008	These results suggest that insulin can prevent neuronal cell death induced by corticosterone in hippocampal neurons by modulating the activity of the PI3 kinase/Akt pathway.	Corticosterone	78-92	insulin	Homo sapiens	27-34
18679014-6	2008	These results suggest that insulin can prevent neuronal cell death induced by corticosterone in hippocampal neurons by modulating the activity of the PI3 kinase/Akt pathway.	Corticosterone	78-92	peptidase inhibitor 3	Homo sapiens	150-153
18679014-6	2008	These results suggest that insulin can prevent neuronal cell death induced by corticosterone in hippocampal neurons by modulating the activity of the PI3 kinase/Akt pathway.	Corticosterone	78-92	AKT serine/threonine kinase 1	Homo sapiens	161-164
18679041-1	2008	The effects of corticosterone (CORT), a natural glucocorticoid hormone, on ATP-induced currents in rat dorsal root ganglion (DRG) neurons and the underlying signaling mechanism were studied by using patch-clamp techniques.	Corticosterone	15-29	cortistatin	Rattus norvegicus	31-35
18655871-2	2008	Oxytocin knockout (OXTKO) mice, a genetic model of OXT deficiency, have heightened corticosterone release after acute stress and greater anxiety-related behaviour in an elevated plus maze compared to wild-type (WT) mice.	Corticosterone	83-97	oxytocin	Mus musculus	0-8
18655871-9	2008	CBR1 antagonists are known to diminish food intake and to enhance corticosterone both basally and following acute stress.	Corticosterone	66-80	cannabinoid receptor 1 (brain)	Mus musculus	0-4
17976922-3	2008	We demonstrate that the genetic inactivation of CB1 is accompanied by increased plasma corticosterone levels both under basal conditions and at different time points following exposure to the FST.	Corticosterone	87-101	cannabinoid receptor 1 (brain)	Mus musculus	48-51
17976922-5	2008	Further experiments confirmed the specificity of corticosterone-elevating SR141716 actions for CB1 in CB1-deficient mice.	Corticosterone	49-63	cannabinoid receptor 1 (brain)	Mus musculus	95-98
17976922-5	2008	Further experiments confirmed the specificity of corticosterone-elevating SR141716 actions for CB1 in CB1-deficient mice.	Corticosterone	49-63	cannabinoid receptor 1 (brain)	Mus musculus	102-105
18037570-10	2008	Mice lacking the IL1R1 exhibited adrenal hypertrophy, thymic involution, and elevated serum corticosterone levels in response to the stressor but did not show splenic accumulation of CD11b(+) cells and failed to develop GC resistance.	Corticosterone	92-106	interleukin 1 receptor, type I	Mus musculus	17-22
17950991-6	2007	The concentration of cell-surface LH and prolactin receptors were significantly reduced after corticosterone exposure whereas the concentration of insulin receptor was diminished only at 200-800 nM doses of corticosterone.	Corticosterone	207-221	insulin receptor	Rattus norvegicus	147-163
17950991-7	2007	The levels of LH and prolactin receptor mRNAs were significantly decreased after corticosterone (100-800 nM) exposure whereas the mRNA level of insulin receptor was significantly reduced only at 800 nM dose of corticosterone.	Corticosterone	81-95	prolactin receptor	Rattus norvegicus	21-39
17950991-7	2007	The levels of LH and prolactin receptor mRNAs were significantly decreased after corticosterone (100-800 nM) exposure whereas the mRNA level of insulin receptor was significantly reduced only at 800 nM dose of corticosterone.	Corticosterone	210-224	insulin receptor	Rattus norvegicus	144-160
17848629-5	2007	(Pro(3))GIP treatment also significantly decreased circulating glucagon and corticosterone, but concentrations of GLP-1, GIP, resistin, and adiponectin were unchanged.	Corticosterone	76-90	gastric inhibitory polypeptide	Mus musculus	8-11
17785918-7	2007	In addition, PRL increased the stimulatory effect of ACTH-induced corticosterone secretion in all rat models.	Corticosterone	66-80	prolactin	Rattus norvegicus	13-16
17785918-9	2007	Additionally, these studies emphasize that the adrenal cortex might be more sensitive to ACTH stimulation in endocrine milieu with high levels of PRL resulting in high corticosterone and progesterone release.	Corticosterone	168-182	prolactin	Rattus norvegicus	146-149
17291374-2	2007	BDNF interacts with components of the stress response such as corticosterone, and plays an important role in growth, maintenance and functioning of several neuronal systems.	Corticosterone	62-76	brain-derived neurotrophic factor	Rattus norvegicus	0-4
17356567-8	2007	Desipramine decreased corticosterone levels in both FVB/N controls and in abcb1ab (-/-) mice, but in abcb1ab (-/-) mice the effects were smaller.	Corticosterone	22-36	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	74-79
17595225-4	2007	In the absence of adrenals, a complete suppression of Tph2 mRNA rhythm was observed in dorsal and median raphe over 24 h. The restoration of corticosterone daily variations in adrenalectomized rats induced a Tph2 mRNA rhythmic pattern de novo, indicating that Tph2 mRNA rhythm is dependent upon daily fluctuations of glucocorticoids.	Corticosterone	141-155	tryptophan hydroxylase 2	Rattus norvegicus	54-58
17595225-4	2007	In the absence of adrenals, a complete suppression of Tph2 mRNA rhythm was observed in dorsal and median raphe over 24 h. The restoration of corticosterone daily variations in adrenalectomized rats induced a Tph2 mRNA rhythmic pattern de novo, indicating that Tph2 mRNA rhythm is dependent upon daily fluctuations of glucocorticoids.	Corticosterone	141-155	tryptophan hydroxylase 2	Rattus norvegicus	208-212
17595225-4	2007	In the absence of adrenals, a complete suppression of Tph2 mRNA rhythm was observed in dorsal and median raphe over 24 h. The restoration of corticosterone daily variations in adrenalectomized rats induced a Tph2 mRNA rhythmic pattern de novo, indicating that Tph2 mRNA rhythm is dependent upon daily fluctuations of glucocorticoids.	Corticosterone	141-155	tryptophan hydroxylase 2	Rattus norvegicus	208-212
17595225-8	2007	The corticosterone surge acts as a rhythmic cue that induces the rhythmic expression of Tph2 in the raphe neurons.	Corticosterone	4-18	tryptophan hydroxylase 2	Rattus norvegicus	88-92
17881205-7	2007	The results showed that prenatal chronic nicotine exposure causes IUGR in rats (P&lt;0.01); in response to nicotine exposure, maternal serum corticosterone levels were elevated at mid- and late-gestations (P&lt;0.05); mRNA expressions of StAR and P450scc increased in maternal adrenals (P&lt;0.05 or 0.01) but decreased in fetal adrenals (P=0.16 or 0.11).	Corticosterone	141-155	steroidogenic acute regulatory protein	Rattus norvegicus	238-242
17881205-7	2007	The results showed that prenatal chronic nicotine exposure causes IUGR in rats (P&lt;0.01); in response to nicotine exposure, maternal serum corticosterone levels were elevated at mid- and late-gestations (P&lt;0.05); mRNA expressions of StAR and P450scc increased in maternal adrenals (P&lt;0.05 or 0.01) but decreased in fetal adrenals (P=0.16 or 0.11).	Corticosterone	141-155	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	247-254
17678929-5	2007	Using artificially selected lines of zebra finches that vary in the amount of corticosterone produced in response to a manual restraint stressor we ran three "personality" experiments.	Corticosterone	78-92	GTP-binding nuclear protein Ran	Parus major	148-151
17922714-12	2007	In young breeders, the combination of a robust corticosterone increase with a lower ability to maintain prolactin secretion during acute stress is probably one of the functional causes of their lower incubation commitment.	Corticosterone	47-61	prolactin	Gallus gallus	104-113
17914980-0	2007	Regulatory effects of corticosterone on ornithine decarboxylase activity during liver regeneration in rats.	Corticosterone	22-36	ornithine decarboxylase 1	Rattus norvegicus	40-63
17914980-1	2007	AIMS: The regulation of ornithine decarboxylase (ODC) gene expression and enzyme activity by corticosterone during rat liver regeneration induced by partial hepatectomy (PH) was evaluated.	Corticosterone	93-107	ornithine decarboxylase 1	Rattus norvegicus	24-47
17914980-1	2007	AIMS: The regulation of ornithine decarboxylase (ODC) gene expression and enzyme activity by corticosterone during rat liver regeneration induced by partial hepatectomy (PH) was evaluated.	Corticosterone	93-107	ornithine decarboxylase 1	Rattus norvegicus	49-52
17914980-7	2007	Corticosterone treatment resulted in a dose-dependent decrease in ODC mRNA content after 5 h post-PH.	Corticosterone	0-14	ornithine decarboxylase 1	Rattus norvegicus	66-69
17914980-8	2007	ODC protein accumulation in adrenalectomy rats was higher than that in sham-adrenalectomy rats, but it decreased in corticosterone-treated (10 mg/kg) rats until 24 h post-PH, with a strong decline seen in 40 mg/kg corticosterone-treated rats.	Corticosterone	116-130	ornithine decarboxylase 1	Rattus norvegicus	0-3
17914980-8	2007	ODC protein accumulation in adrenalectomy rats was higher than that in sham-adrenalectomy rats, but it decreased in corticosterone-treated (10 mg/kg) rats until 24 h post-PH, with a strong decline seen in 40 mg/kg corticosterone-treated rats.	Corticosterone	214-228	ornithine decarboxylase 1	Rattus norvegicus	0-3
17914980-11	2007	CONCLUSIONS: Corticosterone treatment results in dose-dependent decreases in ODC mRNA and enzyme protein both in the intact liver and the regenerating liver.	Corticosterone	13-27	ornithine decarboxylase 1	Rattus norvegicus	77-80
17927667-0	2007	Effect of the glucocorticoid receptor antagonist Org 34850 on basal and stress-induced corticosterone secretion.	Corticosterone	87-101	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	14-37
17975261-6	2007	Primary cultured human BMCs infected with adenovirus containing bovine SF-1 cDNA could produce progesterone, corticosterone, cortisol, dehydroepiandrosterone, testosterone, and estradiol.	Corticosterone	109-123	splicing factor 1	Bos taurus	71-75
17855755-2	2007	Adult male (but not female) rats previously subjected to a stress such as neonatal maternal separation (NMS) are characterized by chronic elevation of plasma corticosterone (Cort) levels and an abnormally elevated hypoxic ventilatory response through mechanisms that remain unknown.	Corticosterone	158-172	cortistatin	Rattus norvegicus	174-178
17884253-8	2007	(Pro(3))GIP treatment significantly reduced plasma corticosterone (P&lt;0.05), while combined administration with PYY(3-36) significantly lowered serum glucagon (P&lt;0.05).	Corticosterone	51-65	gastric inhibitory polypeptide	Mus musculus	8-11
17869410-14	2007	The findings indicate that both corticosterone and progesterone could affect intracellular insulin degradation and crinophagy solely via the glucocorticoid receptor, and that prostaglandins may have a regulatory role in intracellular turnover of secretory material in pancreatic islet beta-cells.	Corticosterone	32-46	nuclear receptor subfamily 3, group C, member 1	Mus musculus	141-164
17848165-5	2007	Corticosterone (CORT), an adrenal hormone produced at increased concentrations during a stress response, has been shown to play a role in impaired CTL responses in stressed animals, leading to high mortality in mice normally resistant to viral infection.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
17651852-7	2007	These data suggest that the COX-2-dependent pathway appears to assist TMT-induced degeneration of CA1 pyramidal cells but not CA3 pyramidal cells in a corticosterone-independent manner.	Corticosterone	151-165	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	28-33
17938813-8	2007	Adipose PAI-1 expression significantly correlated with serum corticosterone levels in both genotypes (wild-type, r = 0.52, p &lt; 0.05; db/db, r = 0.51, p &lt; 0.01), suggesting that adipose PAI-1 expression is up-regulated by fasting-induced glucocorticoids.	Corticosterone	61-75	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	8-13
17588937-4	2007	11beta-HSD1 interconverts hormonally active C11beta-hydroxy steroids (cortisol in humans and corticosterone in rodents) to inactive C11-oxo steroids (cortisone and 11-dehydrocorticosterone, respectively).	Corticosterone	93-107	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	0-11
17785423-6	2007	Increased levels of corticosterone, which modulates lymphocyte activation responses and apoptosis during stress, were found only in OPN(+/+) mice.	Corticosterone	20-34	secreted phosphoprotein 1	Mus musculus	132-135
17785423-9	2007	These results reveal that OPN is required for enhanced corticosterone production, immune organ atrophy, and weight loss in mice subjected to HU.	Corticosterone	55-69	secreted phosphoprotein 1	Mus musculus	26-29
17578887-9	2007	In contrast CRFR1 inhibition in the PVN blunted corticosterone but not epinephrine or glucagon CRR to hypoglycemia.	Corticosterone	48-62	corticotropin releasing hormone receptor 1	Rattus norvegicus	12-17
17595220-5	2007	The elevated plasma profile of corticosterone after CRH stimulation in saline-treated OZR compared with LZR confirmed that the sensitization of the PA axis depended on leptin resistance.	Corticosterone	31-45	corticotropin releasing hormone	Rattus norvegicus	52-55
17595220-7	2007	Only high ANG induced an elevation of the corticosterone and glucose response after CRH stimulation in OZR but did not affect the ACTH secretion.	Corticosterone	42-56	angiogenin	Rattus norvegicus	10-13
17595220-8	2007	During OGTT, corticosterone and consequently glucose increased in OZR after high ANG, whereas the insulin secretion was decreased.	Corticosterone	13-27	angiogenin	Rattus norvegicus	81-84
17336942-0	2007	Regulation of serotonin-1A receptor function in inducible brain-derived neurotrophic factor knockout mice after administration of corticosterone.	Corticosterone	130-144	brain derived neurotrophic factor	Mus musculus	58-91
17336942-1	2007	BACKGROUND: We examined the effects of a forebrain-specific reduction in brain-derived neurotrophic factor (BDNF) on the regulation of serotonin-1A (5-HT1A) receptor function in serotonergic cell body areas as well as in limbic and cortical structures of mice chronically treated with corticosterone.	Corticosterone	285-299	brain derived neurotrophic factor	Mus musculus	108-112
17336942-6	2007	Corticosterone treatment of control mice decreased 5-HT1A receptor function in the dorsal and median raphe but not in hippocampus or frontal cortical areas.	Corticosterone	0-14	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	51-66
17336942-7	2007	The regulation of 5HT1A receptor number or function in the dorsal and median raphe by corticosterone was lost in BDNF knockout mice.	Corticosterone	86-100	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	18-32
17336942-7	2007	The regulation of 5HT1A receptor number or function in the dorsal and median raphe by corticosterone was lost in BDNF knockout mice.	Corticosterone	86-100	brain derived neurotrophic factor	Mus musculus	113-117
17336942-8	2007	CONCLUSIONS: Attenuation of BDNF expression in forebrain regions produces differential effects on distinct 5-HT1A receptor populations and on the regulation of these receptor populations by corticosterone.	Corticosterone	190-204	brain derived neurotrophic factor	Mus musculus	28-32
17712479-1	2007	AIM: To investigate the activation of the nuclear factor of activated T cells (NFAT) and its function in the corticosterone (CORT)-induced apoptosis of rat Leydig cells.	Corticosterone	109-123	nuclear factor of activated T-cells 5	Rattus norvegicus	79-83
17712479-1	2007	AIM: To investigate the activation of the nuclear factor of activated T cells (NFAT) and its function in the corticosterone (CORT)-induced apoptosis of rat Leydig cells.	Corticosterone	109-123	cortistatin	Rattus norvegicus	125-129
17082516-3	2007	Treatment with the glucocorticoid receptor-selective agonist dexamethasone and with the natural adrenosteroid, corticosterone (CORT), results in significant reductions in the total length of apical dendrites in the pyramidal neurons in lamina II/III of the anterior cingulate/prelimbic and infralimbic cortices.	Corticosterone	111-125	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	19-42
17082516-3	2007	Treatment with the glucocorticoid receptor-selective agonist dexamethasone and with the natural adrenosteroid, corticosterone (CORT), results in significant reductions in the total length of apical dendrites in the pyramidal neurons in lamina II/III of the anterior cingulate/prelimbic and infralimbic cortices.	Corticosterone	127-131	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	19-42
17594906-0	2007	The effects of acute corticosterone administration on anxiety, endogenous corticosterone, and c-Fos expression in the rat brain.	Corticosterone	21-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	94-99
17594906-5	2007	It is suggested that the behavioral effects of acute pretreatment of rats with corticosterone could be due to changes in the mnemonic processes in the brain, inhibition of brain corticotropin releasing factor (CRF) synthesis, or stimulation of GABA-A receptor modulating neurosteroids synthesis.	Corticosterone	79-93	corticotropin releasing hormone	Rattus norvegicus	178-208
17675020-3	2007	The attachment and "adult-like" systems appear to co-exist in older pups with maternal presence engaging the attachment system by lowering corticosterone (CORT).	Corticosterone	139-153	cortistatin	Rattus norvegicus	155-159
17680885-5	2007	Orexin expression in the lateral hypothalamus was significantly increased in corticosterone deficient Pomc(-/-) mice.	Corticosterone	77-91	hypocretin	Mus musculus	0-6
17680885-5	2007	Orexin expression in the lateral hypothalamus was significantly increased in corticosterone deficient Pomc(-/-) mice.	Corticosterone	77-91	pro-opiomelanocortin-alpha	Mus musculus	102-106
17536010-2	2007	Using 5-wk-old male chicks, simultaneous iv injections of CRH and AVT were found to result in a greater than additive increase in plasma corticosterone levels compared with that obtained with individual administration of either peptide hormone.	Corticosterone	137-151	corticotropin releasing hormone	Homo sapiens	58-61
17550978-8	2007	These biomarkers arise from PPARalpha effects on tryptophan, corticosterone, and fatty acid metabolism and on glucuronidation.	Corticosterone	61-75	peroxisome proliferator activated receptor alpha	Mus musculus	28-37
17881135-7	2007	Investigating the impact of acute MDR1 p-gp inhibition on the glucocorticoid system, we observed a significant attenuation of the mild stress-induced increase of plasma corticosterone after tariquidar administration.	Corticosterone	169-183	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	34-38
17881135-7	2007	Investigating the impact of acute MDR1 p-gp inhibition on the glucocorticoid system, we observed a significant attenuation of the mild stress-induced increase of plasma corticosterone after tariquidar administration.	Corticosterone	169-183	phosphoglycolate phosphatase	Mus musculus	39-43
17928160-5	2007	In detail, DHEA, DHEA-S, PREG, PREG-S and ALLO induced corticotropin-releasing hormone (CRH) and/or arginine vasopressin (AVP) synthesis and release at the hypothalamic level, thus enhancing plasma adrenocorticotropin hormone (ACTH) and corticosterone (CORT) concentrations.	Corticosterone	237-251	corticotropin releasing hormone	Rattus norvegicus	55-86
17928160-5	2007	In detail, DHEA, DHEA-S, PREG, PREG-S and ALLO induced corticotropin-releasing hormone (CRH) and/or arginine vasopressin (AVP) synthesis and release at the hypothalamic level, thus enhancing plasma adrenocorticotropin hormone (ACTH) and corticosterone (CORT) concentrations.	Corticosterone	237-251	corticotropin releasing hormone	Rattus norvegicus	88-91
17640624-12	2007	In conclusion, these data (i) confirm that heat load is important in the calibration of the risk attached to heat exposure; and (ii) suggest that corticosterone synthesis inhibition may favor TNF-alpha mRNA expression without any effect on Hsp70 mRNA expression.	Corticosterone	146-160	tumor necrosis factor	Rattus norvegicus	192-201
17699659-8	2007	Consistent with this observation, we found enhanced nAChR responses in vitro after a 48 h corticosterone treatment and in vivo after 48 h of repeated stress.	Corticosterone	90-104	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	52-57
17699665-7	2007	Transgenic mice with GR overexpression in forebrain (GRov) display normal basal circulating adrenocorticotropic hormone and corticosterone levels.	Corticosterone	124-138	nuclear receptor subfamily 3, group C, member 1	Mus musculus	21-23
17670946-3	2007	Besides the increased inflammatory response, LRH-1 heterozygous mice exposed to 2,4,6-trinitrobenzene sulfonic acid show lower local corticosterone production as a result of an impaired intestinal expression of the enzymes CYP11A1 and CYP11B1, which control the local synthesis of corticosterone in the intestine.	Corticosterone	133-147	nuclear receptor subfamily 5, group A, member 2	Mus musculus	45-50
17670946-3	2007	Besides the increased inflammatory response, LRH-1 heterozygous mice exposed to 2,4,6-trinitrobenzene sulfonic acid show lower local corticosterone production as a result of an impaired intestinal expression of the enzymes CYP11A1 and CYP11B1, which control the local synthesis of corticosterone in the intestine.	Corticosterone	281-295	nuclear receptor subfamily 5, group A, member 2	Mus musculus	45-50
17463058-4	2007	Infusion of 0.5 nmol NPY into the third ventricle increased plasma corticosterone levels in conscious rats, with the peak of hormone levels occurring 30 min after injection.	Corticosterone	67-81	neuropeptide Y	Rattus norvegicus	21-24
17463058-7	2007	Bilateral infusion of the Y1/Y5 agonist, [leu(31)pro(34)]NPY (110 pmol), into the PVN increased c-Fos and phosphorylated cAMP response element-binding protein expression and elevated plasma corticosterone levels.	Corticosterone	190-204	neuropeptide Y	Rattus norvegicus	57-60
17494996-2	2007	Angiotensin II and aldosterone (corticosterone in rodents) together generate reactive oxygen species (ROS) via reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, which likely facilitate this hypertrophy and remodeling.	Corticosterone	32-46	angiotensinogen	Rattus norvegicus	0-14
17293846-1	2007	Corticotropin-releasing hormone receptor type 1 (CRH-R1)-deficient mice display reduced anxiety-like behavior, a chronic corticosterone deficit, and an impaired neuroendocrine stress response caused by disruption of the hypothalamic-pituitary-adrenocortical (HPA) axis.	Corticosterone	121-135	corticotropin releasing hormone receptor 1	Mus musculus	0-47
17293846-1	2007	Corticotropin-releasing hormone receptor type 1 (CRH-R1)-deficient mice display reduced anxiety-like behavior, a chronic corticosterone deficit, and an impaired neuroendocrine stress response caused by disruption of the hypothalamic-pituitary-adrenocortical (HPA) axis.	Corticosterone	121-135	corticotropin releasing hormone receptor 1	Mus musculus	49-55
17670974-2	2007	The purpose of this study was to determine whether exposure to chronic corticosterone (CORT) under conditions that produce CA3 dendritic retraction would enhance CA3 susceptibility to IBO.	Corticosterone	71-85	cortistatin	Rattus norvegicus	87-91
17670974-2	2007	The purpose of this study was to determine whether exposure to chronic corticosterone (CORT) under conditions that produce CA3 dendritic retraction would enhance CA3 susceptibility to IBO.	Corticosterone	71-85	carbonic anhydrase 3	Rattus norvegicus	123-126
17670974-2	2007	The purpose of this study was to determine whether exposure to chronic corticosterone (CORT) under conditions that produce CA3 dendritic retraction would enhance CA3 susceptibility to IBO.	Corticosterone	71-85	carbonic anhydrase 3	Rattus norvegicus	162-165
17519522-1	2007	Prolactin (PRL) has been proposed to directly stimulate corticosterone release.	Corticosterone	56-70	prolactin	Rattus norvegicus	0-9
17519522-1	2007	Prolactin (PRL) has been proposed to directly stimulate corticosterone release.	Corticosterone	56-70	prolactin	Rattus norvegicus	11-14
17519522-3	2007	The aim of this study was to investigate the effect of PRL on the secretion of corticosterone and progesterone using an in vitro cell culture system in male rats.	Corticosterone	79-93	prolactin	Rattus norvegicus	55-58
17519522-4	2007	Administration of PRL (10(-7) and 10(-6) M) resulted in dose-dependent increases in corticosterone and progesterone release.	Corticosterone	84-98	prolactin	Rattus norvegicus	18-21
17519522-5	2007	Cotreatment with PRL produced an increase in the stimulatory effects of ACTH-induced corticosterone and progesterone secretion.	Corticosterone	85-99	prolactin	Rattus norvegicus	17-20
17519522-6	2007	However, the PRL-induced corticosterone and progesterone releases were significantly reduced by treatment with AG490, a specific Janus kinase 2 (Jak2) inhibitor.	Corticosterone	25-39	prolactin	Rattus norvegicus	13-16
17519522-6	2007	However, the PRL-induced corticosterone and progesterone releases were significantly reduced by treatment with AG490, a specific Janus kinase 2 (Jak2) inhibitor.	Corticosterone	25-39	Janus kinase 2	Rattus norvegicus	129-143
17519522-6	2007	However, the PRL-induced corticosterone and progesterone releases were significantly reduced by treatment with AG490, a specific Janus kinase 2 (Jak2) inhibitor.	Corticosterone	25-39	Janus kinase 2	Rattus norvegicus	145-149
17519522-7	2007	In addition, administration of AG490 blunted the significant inhibition of ACTH-induced corticosterone and progesterone secretion by PRL.	Corticosterone	88-102	prolactin	Rattus norvegicus	133-136
17519522-8	2007	These results demonstrated that PRL could act directly on the adrenal gland to drive corticosterone and progesterone secretion in male rats.	Corticosterone	85-99	prolactin	Rattus norvegicus	32-35
17505056-7	2007	In vivo analysis of urinary steroid excretion by gas chromatography/mass spectrometry in 11 patients with POR mutations showed that A287P homozygous patients had the highest corticosterone/cortisol metabolite ratios, further indicative of preferential inhibition of CYP17A1.	Corticosterone	174-188	cytochrome p450 oxidoreductase	Homo sapiens	106-109
17228340-8	2007	In conclusion, the data indicate that chronic stress, RU 38486 treatment as well as acute rises in corticosterone level strongly modulate calcium influx into CA1 neurons.	Corticosterone	99-113	carbonic anhydrase 1	Rattus norvegicus	158-161
17879592-5	2007	Moreover, TREK-1-deficient mice showed a reduced elevation of corticosterone level under stress, an increased efficacy of 5-HT neurotransmission and an increased fluoxetine-induced neurogenesis in the hippocampus.	Corticosterone	62-76	potassium channel, subfamily K, member 2	Mus musculus	10-16
17562391-0	2007	Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure.	Corticosterone	97-111	BCL2, apoptosis regulator	Rattus norvegicus	38-43
17562391-0	2007	Influence of age or circadian time on Bcl-2 and Bax mRNA expression in the rat hippocampus after corticosterone exposure.	Corticosterone	97-111	BCL2 associated X, apoptosis regulator	Rattus norvegicus	48-51
17611266-4	2007	Pretreatment of stressed rats with the glucocorticoid receptor (GR) antagonist RU38486 prevented the facilitation of DHPG-induced LTD (DHPG-LTD), indicating the involvement of corticosterone secretion and, in turn, stimulation of GRs.	Corticosterone	176-190	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	39-62
17611266-4	2007	Pretreatment of stressed rats with the glucocorticoid receptor (GR) antagonist RU38486 prevented the facilitation of DHPG-induced LTD (DHPG-LTD), indicating the involvement of corticosterone secretion and, in turn, stimulation of GRs.	Corticosterone	176-190	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	64-66
17611266-6	2007	These results indicate that acute stress, through corticosterone stimulation of GRs, facilitates the expression of mGluR1-dependent DHPG-LTD in the hippocampal CA1 region.	Corticosterone	50-64	glutamate metabotropic receptor 1	Rattus norvegicus	115-121
17611266-6	2007	These results indicate that acute stress, through corticosterone stimulation of GRs, facilitates the expression of mGluR1-dependent DHPG-LTD in the hippocampal CA1 region.	Corticosterone	50-64	carbonic anhydrase 1	Rattus norvegicus	160-163
17374695-8	2007	Tg-MSH also attenuated the increase in corticosterone induced by the HFD.	Corticosterone	39-53	msh homeobox 1	Mus musculus	3-6
17456638-5	2007	Male UCN1-KO mice did not show any adaptation to repeated restraint; instead, restraint-stimulated corticosterone levels were increased from 274 +/- 80 ng/ml in naive animals to 480 +/- 75 ng/ml in mice subjected to repeated restraint (P &lt; 0.001).	Corticosterone	99-113	urocortin	Mus musculus	5-9
17456638-6	2007	Female UCN1-KO mice showed only a partial adaptation to repeated restraint, with a decrease in the restraint-stimulated corticosterone response from 631 +/- 102 ng/ml in naive animals to 467 +/- 78 ng/ml in mice subjected to repeated restraint (P &lt; 0.01).	Corticosterone	120-134	urocortin	Mus musculus	7-11
17456638-8	2007	These data demonstrate an important role for UCN1 in the HPA axis adaptation to repeated restraint and in the corticosterone response to a cold environment.	Corticosterone	110-124	urocortin	Mus musculus	45-49
17222530-9	2007	In contrast, both WT and mutant strains, as well as IL-1ra-treated mice, displayed analgesic and corticosterone responses following moderate and severe stress.	Corticosterone	97-111	interleukin 1 receptor antagonist	Mus musculus	52-58
17631244-2	2007	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyses intracellular regeneration of active glucocorticoids (cortisol, corticosterone) from inert 11-keto forms in liver, adipose and brain, amplifying local action.	Corticosterone	131-145	RNA, U1 small nuclear 1	Homo sapiens	0-55
17473064-14	2007	TLR-9 stimulation led to a corticosterone and inflammatory cytokine response.	Corticosterone	27-41	toll-like receptor 9	Mus musculus	0-5
17592030-3	2007	Upon exogenous glucocorticoid replacement, corticosterone-supplemented (CORT) Pomc-/- mice show exaggerated responses, including excessive fat accumulation, hyperleptinaemia and insulin resistance.	Corticosterone	43-57	cortistatin	Mus musculus	72-76
17592030-3	2007	Upon exogenous glucocorticoid replacement, corticosterone-supplemented (CORT) Pomc-/- mice show exaggerated responses, including excessive fat accumulation, hyperleptinaemia and insulin resistance.	Corticosterone	43-57	pro-opiomelanocortin-alpha	Mus musculus	78-82
17164814-6	2007	Moreover, the basal level of corticosterone was found to be significantly lower in GAT1(-/-) mice.	Corticosterone	29-43	solute carrier family 6 (neurotransmitter transporter, GABA), member 1	Mus musculus	83-87
17540506-1	2007	The stress level of corticosterone (CORT) may enhance the vulnerability of neurons to insult by increasing N-methyl-D-aspartate (NMDA) receptor activity.	Corticosterone	20-34	cortistatin	Homo sapiens	36-40
17537461-6	2007	It was found that infusion of rats with ACTH for 1 h caused an increase of adrenal ALA-s mRNA and activity accompanied by an increase in plasma corticosterone.	Corticosterone	144-158	proopiomelanocortin	Homo sapiens	40-44
17537461-7	2007	CYP21, a cytochrome involved in the synthesis of both corticosterone and aldosterone, was not modified at the RNA level in adrenal glands by 1 h of ACTH infusion.	Corticosterone	54-68	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	0-5
17481824-10	2007	CRH levels in the hypothalamus and the plasma corticosterone response to CRH administration were found to be higher in stressed rats than in controls.	Corticosterone	46-60	corticotropin releasing hormone	Rattus norvegicus	73-76
17394575-12	2007	In this work, we used corticotropin-releasing hormone (CRH) knockout mice, where secretion of corticosterone and subsequently adrenaline is significantly suppressed.	Corticosterone	94-108	corticotropin releasing hormone	Mus musculus	22-53
17394575-12	2007	In this work, we used corticotropin-releasing hormone (CRH) knockout mice, where secretion of corticosterone and subsequently adrenaline is significantly suppressed.	Corticosterone	94-108	corticotropin releasing hormone	Mus musculus	55-58
17394575-13	2007	As no increase in NCX1 mRNA was observed in CRH knockout mice due to immobilization stress, we proposed that adrenaline (probably regulated via corticosterone) is involved in the regulation of NCX1 gene expression during stress.	Corticosterone	144-158	T cell leukemia, homeobox 2	Mus musculus	193-197
17434149-6	2007	Adrenalectomy reduced CART expression in the dentate gyrus but not the amygdala and this effect was blocked by corticosterone but not RU28,362 or aldosterone replacement, suggesting a synergism of mineralocorticoid and glucocorticoid receptors.	Corticosterone	111-125	CART prepropeptide	Rattus norvegicus	22-26
17584152-4	2007	The conversion of inactive 11-ketoglucocorticoids (cortisone and 11-dehydrocorticosterone) into active 11beta-hydroxyglucocorticoids (cortisol and corticosterone) is catalyzed by 11beta-HSD1, which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver, adipose tissue and skeletal muscles.	Corticosterone	75-89	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	179-190
17462630-0	2007	Central neural distribution of immunoreactive Fos and CRH in relation to plasma ACTH and corticosterone during sepsis in the rat.	Corticosterone	89-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-49
17462630-0	2007	Central neural distribution of immunoreactive Fos and CRH in relation to plasma ACTH and corticosterone during sepsis in the rat.	Corticosterone	89-103	corticotropin releasing hormone	Rattus norvegicus	54-57
17462630-6	2007	The number of Fos-positive cell nuclei in the NTS on D3 and D4 did not differ but had greater variance on D3 than on D4 (P&lt;0.01) with a divergent response in the PM of D3 that was correlated with plasma ACTH (r=0.927, P&lt;0.01) but not with corticosterone.	Corticosterone	245-259	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
17557067-4	2007	RESULTS: The results show that exposure of rats to a 60-min swimming stress provokes corticosterone secretion, which results in a rapid depletion of GR from renal cytosol and the subsequent induction of the renal Na(+)-K(+)-ATPase.	Corticosterone	85-99	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	149-151
17383615-1	2007	We previously assessed corticosterone mediated gene expression in acute explant hippocampal slices and found over 200 responsive genes 1, 3 and 5 h after glucocorticoid receptor (GR) activation by a brief corticosterone pulse.	Corticosterone	23-37	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	154-177
17383615-1	2007	We previously assessed corticosterone mediated gene expression in acute explant hippocampal slices and found over 200 responsive genes 1, 3 and 5 h after glucocorticoid receptor (GR) activation by a brief corticosterone pulse.	Corticosterone	23-37	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	179-181
17383615-1	2007	We previously assessed corticosterone mediated gene expression in acute explant hippocampal slices and found over 200 responsive genes 1, 3 and 5 h after glucocorticoid receptor (GR) activation by a brief corticosterone pulse.	Corticosterone	205-219	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	154-177
17383615-1	2007	We previously assessed corticosterone mediated gene expression in acute explant hippocampal slices and found over 200 responsive genes 1, 3 and 5 h after glucocorticoid receptor (GR) activation by a brief corticosterone pulse.	Corticosterone	205-219	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	179-181
17383615-3	2007	The aim of the current experiment was 1) to measure the expression of several of these neurotransmission-related genes that were corticosterone-responsive 1 h after GR-activation in an in vivo setting, 2) to elucidate in which hippocampal subregion these expression changes take place and 3) to assess the specificity of regulation by activated GRs.	Corticosterone	129-143	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	165-167
17383615-4	2007	For this purpose, rats were subcutaneously injected with vehicle, corticosterone or corticosterone pretreated with GR-antagonist RU38486.	Corticosterone	84-98	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	115-117
17383615-6	2007	The mineralocorticoid receptor (MR), MAO-A, casein kinase 2 and voltage dependent potassium mRNA"s, but not dynein mRNA, were rapidly downregulated in vivo after corticosterone administration in hippocampal subregions.	Corticosterone	162-176	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	4-30
17383615-6	2007	The mineralocorticoid receptor (MR), MAO-A, casein kinase 2 and voltage dependent potassium mRNA"s, but not dynein mRNA, were rapidly downregulated in vivo after corticosterone administration in hippocampal subregions.	Corticosterone	162-176	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	32-34
17383615-6	2007	The mineralocorticoid receptor (MR), MAO-A, casein kinase 2 and voltage dependent potassium mRNA"s, but not dynein mRNA, were rapidly downregulated in vivo after corticosterone administration in hippocampal subregions.	Corticosterone	162-176	monoamine oxidase A	Rattus norvegicus	37-42
17383615-7	2007	Furthermore, RU38486 pretreatment reversed in all cases these effects, illustrating the GR-specificity of transcriptional regulation by corticosterone.	Corticosterone	136-150	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	88-90
17522027-1	2007	Previous experiments in the hippocampal CA1 area have shown that corticosterone can facilitate long-term potentiation (LTP) in a rapid non-genomic fashion, while the same hormone suppresses LTP that is induced several hours after hormone application.	Corticosterone	65-79	carbonic anhydrase 1	Homo sapiens	40-43
17272666-3	2007	We further hypothesized that UPI downregulates the key enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which converts corticosterone to inert 11-dehydrocorticosterone, thereby protecting both the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) from the actions of corticosterone.	Corticosterone	135-149	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	106-117
17272666-3	2007	We further hypothesized that UPI downregulates the key enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which converts corticosterone to inert 11-dehydrocorticosterone, thereby protecting both the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) from the actions of corticosterone.	Corticosterone	135-149	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	213-236
17272666-3	2007	We further hypothesized that UPI downregulates the key enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which converts corticosterone to inert 11-dehydrocorticosterone, thereby protecting both the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) from the actions of corticosterone.	Corticosterone	135-149	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	238-240
17272666-3	2007	We further hypothesized that UPI downregulates the key enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which converts corticosterone to inert 11-dehydrocorticosterone, thereby protecting both the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) from the actions of corticosterone.	Corticosterone	135-149	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	250-276
17272666-3	2007	We further hypothesized that UPI downregulates the key enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which converts corticosterone to inert 11-dehydrocorticosterone, thereby protecting both the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) from the actions of corticosterone.	Corticosterone	135-149	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	278-280
17272666-3	2007	We further hypothesized that UPI downregulates the key enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), which converts corticosterone to inert 11-dehydrocorticosterone, thereby protecting both the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR) from the actions of corticosterone.	Corticosterone	169-183	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	106-117
17428549-0	2007	Interferon-alpha effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations.	Corticosterone	106-120	interferon alpha	Mus musculus	0-16
17428549-3	2007	In two experiments using CD-1 mice, we demonstrate that intraperitoneal administration of IFN-alpha dose dependently influences plasma corticosterone and sickness behaviors, and modestly influences norepinephrine turnover in brain.	Corticosterone	135-149	interferon alpha	Mus musculus	90-99
17327420-1	2007	The human nuclear pregnane X receptor (PXR) responds to a wide variety of xenobiotic and endobiotic compounds, including pregnanes, progesterones, corticosterones, lithocholic acids, and 17beta-estradiol.	Corticosterone	147-162	nuclear receptor subfamily 1 group I member 2	Homo sapiens	18-37
17327420-1	2007	The human nuclear pregnane X receptor (PXR) responds to a wide variety of xenobiotic and endobiotic compounds, including pregnanes, progesterones, corticosterones, lithocholic acids, and 17beta-estradiol.	Corticosterone	147-162	nuclear receptor subfamily 1 group I member 2	Homo sapiens	39-42
17509676-9	2007	Levels of the stress hormone, corticosterone, were significantly higher in the beta3 null mutant mice at baseline and following exposure to stress.	Corticosterone	30-44	calcium channel, voltage-dependent, beta 3 subunit	Mus musculus	79-84
17460069-2	2007	Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Corticosterone	26-40	cyclin dependent kinase inhibitor 1A	Homo sapiens	136-139
17460069-2	2007	Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Corticosterone	26-40	cyclin dependent kinase inhibitor 1A	Homo sapiens	140-144
17460069-2	2007	Here, we demonstrate that corticosterone protects neurons from apoptosis by a mechanism involving the cyclin-dependent kinase inhibitor p21(Waf1/Cip1).	Corticosterone	26-40	cyclin dependent kinase inhibitor 1A	Homo sapiens	145-149
17460069-3	2007	In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/Cip1) at Thr 145.	Corticosterone	29-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	159-162
17460069-3	2007	In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/Cip1) at Thr 145.	Corticosterone	29-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	163-167
17460069-3	2007	In primary cortical neurons, corticosterone leads to a dose- and Akt-kinase-dependent upregulation with enhanced phosphorylation and cytoplasmic appearance of p21(Waf1/Cip1) at Thr 145.	Corticosterone	29-43	cyclin dependent kinase inhibitor 1A	Homo sapiens	168-172
17460069-6	2007	Corticosterone-mediated upregulation of p21(Waf1/Cip1) and neuroprotection are completely abolished by glucocorticoid and mineralocorticoid receptor antagonists as well as inhibitors of PI3- and Akt-kinase.	Corticosterone	0-14	cyclin dependent kinase inhibitor 1A	Homo sapiens	40-43
17460069-6	2007	Corticosterone-mediated upregulation of p21(Waf1/Cip1) and neuroprotection are completely abolished by glucocorticoid and mineralocorticoid receptor antagonists as well as inhibitors of PI3- and Akt-kinase.	Corticosterone	0-14	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-48
17460069-6	2007	Corticosterone-mediated upregulation of p21(Waf1/Cip1) and neuroprotection are completely abolished by glucocorticoid and mineralocorticoid receptor antagonists as well as inhibitors of PI3- and Akt-kinase.	Corticosterone	0-14	cyclin dependent kinase inhibitor 1A	Homo sapiens	49-53
17460069-6	2007	Corticosterone-mediated upregulation of p21(Waf1/Cip1) and neuroprotection are completely abolished by glucocorticoid and mineralocorticoid receptor antagonists as well as inhibitors of PI3- and Akt-kinase.	Corticosterone	0-14	peptidase inhibitor 3	Homo sapiens	186-189
17460069-7	2007	Both germline and somatically induced p21(Waf1/Cip1) deficiency abrogate the neuroprotection by corticosterone, whereas overexpression of p21(Waf1/Cip1) suffices to protect neurons from apoptosis.	Corticosterone	96-110	cyclin dependent kinase inhibitor 1A	Homo sapiens	38-41
17460069-7	2007	Both germline and somatically induced p21(Waf1/Cip1) deficiency abrogate the neuroprotection by corticosterone, whereas overexpression of p21(Waf1/Cip1) suffices to protect neurons from apoptosis.	Corticosterone	96-110	cyclin dependent kinase inhibitor 1A	Homo sapiens	42-46
17460069-7	2007	Both germline and somatically induced p21(Waf1/Cip1) deficiency abrogate the neuroprotection by corticosterone, whereas overexpression of p21(Waf1/Cip1) suffices to protect neurons from apoptosis.	Corticosterone	96-110	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-51
17005312-6	2007	Moreover, mARP treatment ameliorated post-exposure increases in corticosterone and decreases in AChE gene expression and facilitated earlier retrieval of motor activity following both paraoxon and lipopolysaccharide (LPS) exposures.	Corticosterone	64-78	Arp lymphoid/erythroid hyperplasia	Mus musculus	10-14
17442833-5	2007	In the present study, we examined the direct effects of corticosterone (CORT) on principal neurons of the rat BLA in vitro using whole-cell patch-clamp recordings.	Corticosterone	56-70	cortistatin	Rattus norvegicus	72-76
17324515-2	2007	Corticotropin-releasing factor (CRF), which increases the plasma corticosterone concentration, plays an important role as a mediator of many appetite-suppressive peptides in the central nervous system in both species.	Corticosterone	65-79	corticotropin releasing hormone	Rattus norvegicus	0-30
17148758-7	2007	Combination treatment of mice with alpha-difluoromethylornithine (a suicide inhibitor of ODC) and a polyamine-deficient diet produced a marked decrease in adrenal polyamine and catecholamine levels and a significant reduction in plasma corticosterone and aldosterone concentrations that were not associated with a decrease in the mRNA levels of steroidogenic proteins.	Corticosterone	236-250	ornithine decarboxylase, structural 1	Mus musculus	89-92
17170234-4	2007	Stress increased corticosterone concentration in a manner partially modulated by IL-6.	Corticosterone	17-31	interleukin 6	Rattus norvegicus	81-85
17170234-6	2007	LPS-induced IL-6 secretion by peripheral blood mononuclear cells in vitro correlated positively with serum IL-1beta concentration in antibody-treated groups, independently of stress (R = 0.70 in nonstressed and R = 0.78 in stressed rats; both P &lt; 0.05), whereas serum corticosterone concentration correlated positively with LPS-induced secretion of IL-6 only in control rats (R = 0.66; P &lt; 0.05).	Corticosterone	271-285	interleukin 6	Rattus norvegicus	12-16
17170234-10	2007	In conclusion, IL-6 plays a role in maintaining circulating IL-1beta concentration after multiple exposures to stress, thus promoting a continued elevation of corticosterone release; in peripheral tissues, IL-6 antagonizes the effects of glucocorticoids, especially at the level of GR concentration.	Corticosterone	159-173	interleukin 6	Rattus norvegicus	15-19
17194743-4	2007	Although circadian HPA axis responsiveness is preserved, CB1-/- mice are characterized by an enhanced circadian drive on the HPA axis, resulting in elevated plasma corticosterone concentrations at the onset of the dark as compared with wild-type (CB1+/+) littermates.	Corticosterone	164-178	cannabinoid receptor 1 (brain)	Mus musculus	57-60
17218412-3	2007	Haploinsufficiency in heterozygous glucokinase knockout mice produced effects similar to those produced by hypoglycemia: impaired reproductive function, elevated plasma corticosterone, increased food intake, and hypothalamic gene expression similar to that observed in fasted or leptin-deficient obese mice (increased hypothalamic neuropeptide Y mRNA and reduced hypothalamic proopiomelanocortin mRNA).	Corticosterone	169-183	glucokinase	Mus musculus	35-46
17218420-2	2007	We investigated the expression and cell signaling of CRF2 receptors and ligands in the rat esophagus and lower esophageal sphincter (LES) by RT-PCR and quantitative PCR in normal and corticosterone-treated whole esophageal tissue, laser capture microdissected layers, and isolated esophageal cells.	Corticosterone	183-197	corticotropin releasing hormone receptor 2	Rattus norvegicus	53-57
17873323-6	2007	In contrast, 10(-7) M corticosterone induces significant increases in O2- release, PKCalpha expression and phosphorylation, which cannot be reversed by RU486, demonstrating a previously unrecognized pro-inflammatory role of GCs in enhancing PM activation through a GR-independent pathway.	Corticosterone	22-36	protein kinase C, alpha	Rattus norvegicus	83-91
17334639-6	2007	Investigations carried out in the rat show that galanin is also able to directly stimulate corticosterone (glucocorticoid) secretion from adrenocortical cells, through GAL-R1 and GAL-R2 coupled to the adenylate cyclase-protein kinase A signaling cascade, and nor-epinephrine release from adrenal medulla.	Corticosterone	91-105	galanin receptor 1	Rattus norvegicus	168-185
17289085-6	2007	Treatment with piperine (6.25-25 microM) for 72 h reversed the CORT-induced reduction of BDNF mRNA expression in cultured hippocampal neurons.	Corticosterone	63-67	brain derived neurotrophic factor	Mus musculus	89-93
17254711-8	2007	Lewis rats which have a hyporesponsive feedback in their HPA axis and a longer duration of corticosterone secretion with subchronic methamphetamine were prone to methamphetamine sensitization and their striatal glucocorticoid receptor mRNA levels were downregulated.	Corticosterone	91-105	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	211-234
18039783-4	2008	We found that: 1) expression of the cognate mRNA encoding for the MT1 membrane-bound melatonin receptor, displaying higher levels in the day/night transition (1800-2200 h); 2) expression of the predicted 37-kDa MT1 polypeptide in immunoblots from adrenals collected at 2200 h but not 1000 h; 3) no expression of the MT2 melatonin receptor mRNA and protein; 4) specific high-affinity 2-[(125)I]iodomelatonin binding in membrane fractions and frozen sections from adrenals collected at 2200 h but not 0800 h (dissociation constant = 14.22 +/- 1.23 pm; maximal binding capacity = 0.88 +/- 0.02 fmol/mg protein); and 5) in vitro clock time-dependent inhibition of ACTH-stimulated corticosterone production by 1-100 nm melatonin, which was reversed by 1 microm luzindole (a melatonin membrane receptor antagonist).	Corticosterone	676-690	metallothionein 1	Rattus norvegicus	66-69
18039783-4	2008	We found that: 1) expression of the cognate mRNA encoding for the MT1 membrane-bound melatonin receptor, displaying higher levels in the day/night transition (1800-2200 h); 2) expression of the predicted 37-kDa MT1 polypeptide in immunoblots from adrenals collected at 2200 h but not 1000 h; 3) no expression of the MT2 melatonin receptor mRNA and protein; 4) specific high-affinity 2-[(125)I]iodomelatonin binding in membrane fractions and frozen sections from adrenals collected at 2200 h but not 0800 h (dissociation constant = 14.22 +/- 1.23 pm; maximal binding capacity = 0.88 +/- 0.02 fmol/mg protein); and 5) in vitro clock time-dependent inhibition of ACTH-stimulated corticosterone production by 1-100 nm melatonin, which was reversed by 1 microm luzindole (a melatonin membrane receptor antagonist).	Corticosterone	676-690	metallothionein 1	Rattus norvegicus	211-214
17068162-10	2007	These results suggest that inhibition of VP magnocellular and parvocellular neurons, but not CRH parvocellular neurons, contributes to the suppression of corticosterone after WR-induced drinking.	Corticosterone	154-168	arginine vasopressin	Rattus norvegicus	41-43
17158208-7	2007	The N-terminal peptide ANXA1(Ac2-26) inhibited corticosterone release.	Corticosterone	47-61	annexin A1	Mus musculus	23-28
17158208-8	2007	Corticosterone release was significantly greater from ANXA1-null adrenal cells compared with wild type in response to ACTH (10 pm to 5 nm).	Corticosterone	0-14	annexin A1	Mus musculus	54-59
17158208-11	2007	These results suggest ANXA1 is a regulator of adrenocortical size and corticosterone secretion.	Corticosterone	70-84	annexin A1	Mus musculus	22-27
17432967-5	2007	Chronic PRL treatment exerted an anxiolytic effect on the elevated plus-maze, and attenuated the acute restraint-induced rise in plasma adrenocorticotropin, corticosterone and noradrenaline.	Corticosterone	157-171	prolactin	Rattus norvegicus	8-11
17324399-12	2007	Anti-MIF antibody prevented P-mediated up-regulation of TNF-alpha, improved TNBS colitis, and enhanced plasma corticosterone.	Corticosterone	110-124	macrophage migration inhibitory factor	Rattus norvegicus	5-8
18063678-7	2008	LIG offspring showed impaired glucose tolerance from the age of 15 wk as well as elevated glycosylated hemoglobin and corticosterone levels.	Corticosterone	118-132	ubiquitin-conjugating enzyme E2K	Rattus norvegicus	0-3
17207581-1	2007	The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts the inactive 11-dehydrocorticosterone into the active glucocorticoid corticosterone.	Corticosterone	100-114	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	11-53
17207581-1	2007	The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts the inactive 11-dehydrocorticosterone into the active glucocorticoid corticosterone.	Corticosterone	100-114	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	55-66
17207581-8	2007	These results clearly indicate that circulating corticosterone is downregulating the expression of 11beta-HSD1 mRNA in the two forebrain areas studied.	Corticosterone	48-62	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	99-110
17215160-9	2007	Cortisol and corticosterone decreased the steady-state TSHbeta mRNA levels at the pituitary level, in a dose-related manner, the first-time demonstration in vertebrates.	Corticosterone	13-27	thyrotropin subunit beta	Anas platyrhynchos	55-62
17170103-3	2007	Mice deficient in 11beta-HSD1 (11beta-HSD1(-/-)) exhibit adrenal hyperplasia, raised basal corticosterone levels, and increased hypothalamic-pituitary-adrenal (HPA) axis responses to stress.	Corticosterone	91-105	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	18-29
17170103-3	2007	Mice deficient in 11beta-HSD1 (11beta-HSD1(-/-)) exhibit adrenal hyperplasia, raised basal corticosterone levels, and increased hypothalamic-pituitary-adrenal (HPA) axis responses to stress.	Corticosterone	91-105	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	31-42
17185376-6	2007	Increased AMPK activity persisted in arcuate hypothalamus at 60 min after 2DG injection when serum glucagon and corticosterone levels were increased 2.5- to 3.4-fold.	Corticosterone	112-126	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	10-14
17204493-0	2007	Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring.	Corticosterone	9-23	angiotensin II receptor, type 1a	Rattus norvegicus	52-55
17258216-6	2007	However, vasopressin deficient animals showed higher level of dexamethasone induced suppression of corticosterone response to restraint stress and higher basal levels of corticotropin-releasing hormone mRNA in the hypothalamic paraventricular nucleus.	Corticosterone	99-113	arginine vasopressin	Rattus norvegicus	9-20
17110645-7	2007	In the psychological stress group, but not in the physical stress group, an elevation of the serum corticosterone levels during ovalbumin challenge was significantly attenuated in comparison with the control group.	Corticosterone	99-113	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	128-137
17296558-5	2007	Intake of nonstressful amounts of corticosterone effectively reduced the exaggerated somatic reactions of CRF1-/- mice to opiate withdrawal.	Corticosterone	34-48	corticotropin releasing hormone receptor 1	Mus musculus	106-110
17296558-6	2007	Exogenous corticosterone also restored "wild-type-like" patterns of CRF and dynorphin gene expression in the PVN and the striatum of opiate-withdrawn CRF1-/- mice, respectively.	Corticosterone	10-24	corticotropin releasing hormone receptor 1	Mus musculus	150-154
17332532-10	2007	We confirmed that ACTH increased adrenal weight and corticosterone levels when compared with control or dexamethasone-treated animals.	Corticosterone	52-66	proopiomelanocortin	Homo sapiens	18-22
17332532-12	2007	When ERKs activation was blocked by the use of a specific MEK inhibitor (PD98059), there was a decrease in ACTH-induced corticosterone release and PCNA expression.	Corticosterone	120-134	mitogen-activated protein kinase kinase 7	Homo sapiens	58-61
17332532-12	2007	When ERKs activation was blocked by the use of a specific MEK inhibitor (PD98059), there was a decrease in ACTH-induced corticosterone release and PCNA expression.	Corticosterone	120-134	proopiomelanocortin	Homo sapiens	107-111
16794572-0	2007	Omega-3 fatty acid ethyl-eicosapentaenoate attenuates IL-1beta-induced changes in dopamine and metabolites in the shell of the nucleus accumbens: involved with PLA2 activity and corticosterone secretion.	Corticosterone	178-192	interleukin 1 beta	Homo sapiens	54-62
16794572-7	2007	IL-1 also increased blood concentration of corticosterone and PGE2, and increased the activities of cytosolic and secretory [corrected] PLA2.	Corticosterone	43-57	interleukin 1 beta	Homo sapiens	0-4
16794572-10	2007	Quinacrine, [corrected] a PLA2 antagonist significantly blocked IL-1-induced [corrected] increase in PGE2 and corticosterone concentrations.	Corticosterone	110-124	phospholipase A2 group IB	Homo sapiens	26-30
16794572-10	2007	Quinacrine, [corrected] a PLA2 antagonist significantly blocked IL-1-induced [corrected] increase in PGE2 and corticosterone concentrations.	Corticosterone	110-124	interleukin 1 beta	Homo sapiens	64-68
16794572-11	2007	These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion.	Corticosterone	81-95	interleukin 1 beta	Homo sapiens	47-51
16794572-11	2007	These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion.	Corticosterone	81-95	phospholipase A2 group IB	Homo sapiens	71-75
16794572-11	2007	These results demonstrated the hypotheses that IL-1 effects may be via PLA2-PGE2-corticosterone pathway and EPA attenuated IL-1 effects may be through the suppression of PLA2 expression, which then reduced PGE2 synthesis and corticosterone secretion.	Corticosterone	225-239	phospholipase A2 group IB	Homo sapiens	170-174
17204493-0	2007	Prenatal corticosterone exposure results in altered AT1/AT2, nephron deficit and hypertension in the rat offspring.	Corticosterone	9-23	angiotensin II receptor, type 2	Rattus norvegicus	56-59
17204493-2	2007	However, it is not known whether elevated maternal corticosterone (CORT), the natural glucocorticoid, has similar effects on blood pressure and nephron endowment.	Corticosterone	51-65	cortistatin	Rattus norvegicus	67-71
17143559-0	2007	Galanin enhances corticosterone secretion from dispersed rat adrenocortical cells through the activation of GAL-R1 and GAL-R2 receptors coupled to the adenylate cyclase-dependent signaling cascade.	Corticosterone	17-31	galanin receptor 1	Rattus norvegicus	108-114
16985254-6	2007	Maximum corticosterone production induced by ACTH or dibutyryl cyclic AMP and lipoproteins was not altered in LDLR(-/-) mice but was reduced 80-90% in HSL(-/-) mice.	Corticosterone	8-22	pro-opiomelanocortin-alpha	Mus musculus	45-49
16985254-6	2007	Maximum corticosterone production induced by ACTH or dibutyryl cyclic AMP and lipoproteins was not altered in LDLR(-/-) mice but was reduced 80-90% in HSL(-/-) mice.	Corticosterone	8-22	lipase, hormone sensitive	Mus musculus	151-154
17095588-5	2007	However, adult Pomc(-/-)Tg/+ mice expressing the pituitary-specific transgene exhibited adrenal cortical hypertrophy, elevated basal plasma corticosterone, elevated basal but attenuated stress-induced ACTH secretion, and inappropriately elevated CRH expression in the hypothalamic paraventricular nucleus.	Corticosterone	140-154	pro-opiomelanocortin-alpha	Mus musculus	15-19
17131417-2	2007	We have previously reported that sequential application of corticosterone and kainic acid (CORT + KA) mimicking the nerve injury condition results in synergistic enhancement of neurite outgrowth and expression of growth-associated protein 43 (GAP-43) in cultured dorsal root ganglion (DRG).	Corticosterone	59-73	growth associated protein 43	Rattus norvegicus	213-241
17131417-2	2007	We have previously reported that sequential application of corticosterone and kainic acid (CORT + KA) mimicking the nerve injury condition results in synergistic enhancement of neurite outgrowth and expression of growth-associated protein 43 (GAP-43) in cultured dorsal root ganglion (DRG).	Corticosterone	59-73	growth associated protein 43	Rattus norvegicus	243-249
16641943-7	2007	Surgical adrenalectomy along with diurnal corticosterone (CORT) replacement prevented EFS-induced escalation without altering SA in the absence of EFS, indicating that increases in circulating glucocorticoids were necessary for the escalating effects of EFS.	Corticosterone	42-56	cortistatin	Rattus norvegicus	58-62
17084914-5	2007	A final goal was to assess whether the reductions in adult offspring reactivity to threat that typically follow corticosterone (CORT) administration to dams across lactation are mediated through CORT-induced changes in maternal care.	Corticosterone	112-126	cortistatin	Rattus norvegicus	128-132
17148253-0	2007	Spatial ability is impaired and hippocampal mineralocorticoid receptor mRNA expression reduced in zebra finches (Taeniopygia guttata) selected for acute high corticosterone response to stress.	Corticosterone	158-172	mineralocorticoid receptor	Taeniopygia guttata	44-70
16959946-7	2007	Levels of corticosterone, one of the stress indicators, were lower in IL-18 KO mice than in wild-type mice.	Corticosterone	10-24	interleukin 18	Mus musculus	70-75
15951155-7	2007	These data are consistent with the hypothesis that the sleep response to influenza infection is mediated, in part, by an up-regulation of hypothalamic sleep-related transcripts and they also show that a primary deficit in GHRH signaling is associated with enhanced corticosterone secretion and attenuated hypothalamic cytokine response to infection.	Corticosterone	265-279	growth hormone releasing hormone	Mus musculus	222-226
17135362-3	2007	At the same time, TIF-2(-/-) mice display significantly lower basal corticosterone levels and a sluggish and blunted initial secretory response to brief emotional and prolonged physical stress.	Corticosterone	68-82	nuclear receptor coactivator 2	Mus musculus	18-23
17157327-8	2007	Ghrelin increased circulating concentrations of ACTH and corticosterone (p&lt;0.05) by 62% and 66%, respectively.	Corticosterone	57-71	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
17157327-9	2007	The data provide clear documentation that intracerebroventricular ghrelin stimulates ACTH cell hypertrophy and proliferation, and promotes ACTH and corticosterone release.	Corticosterone	148-162	ghrelin and obestatin prepropeptide	Rattus norvegicus	66-73
17082260-6	2007	Functionally, Pbx1(+/-) mice display a blunted corticosterone response after ACTH stimulation coincident with lower adrenal expression of the ACTH receptor (melanocortin 2 receptor, Mc2-r).	Corticosterone	47-61	pre B cell leukemia homeobox 1	Mus musculus	14-18
17283245-1	2007	The objective of this study was to determine the effects of manipulating glucocorticoid negative feedback on acute ACTH and corticosterone responses to corticotropin-releasing hormone (CRH) injection in 7-day-old rats exposed to normoxia or hypoxia from birth.	Corticosterone	124-138	corticotropin releasing hormone	Rattus norvegicus	185-188
17197073-4	2007	Melanocytes respond with enhanced production of cortisol and corticosterone, which is dependent on POMC activity.	Corticosterone	61-75	proopiomelanocortin	Homo sapiens	99-103
17197073-5	2007	Fibroblasts respond to CRH and ACTH with enhanced production of corticosterone, but not cortisol, which is produced constitutively.	Corticosterone	64-78	corticotropin releasing hormone	Homo sapiens	23-26
17197073-5	2007	Fibroblasts respond to CRH and ACTH with enhanced production of corticosterone, but not cortisol, which is produced constitutively.	Corticosterone	64-78	proopiomelanocortin	Homo sapiens	31-35
17077807-10	2007	iNOS was detectable at low levels in control rats, but was increased markedly following corticosterone.	Corticosterone	88-102	nitric oxide synthase 2	Rattus norvegicus	0-4
17077807-12	2007	Aminoguanidine (100 mg/kg/day; an iNOS antagonist) significantly increased proliferation in corticosterone-treated rats (40 mg/kg/day) but not in controls without additional corticosterone, confirming that iNOS plays a role in corticosterone-regulated neurogenesis.	Corticosterone	92-106	nitric oxide synthase 2	Rattus norvegicus	34-38
17077807-12	2007	Aminoguanidine (100 mg/kg/day; an iNOS antagonist) significantly increased proliferation in corticosterone-treated rats (40 mg/kg/day) but not in controls without additional corticosterone, confirming that iNOS plays a role in corticosterone-regulated neurogenesis.	Corticosterone	92-106	nitric oxide synthase 2	Rattus norvegicus	206-210
16581232-11	2007	Since PKC and ERK-MAPK inhibitors attenuate the corticosterone-mediated gene transcription, the above findings suggest that allopregnanolone effect on GR function involves interaction with these kinase pathways.	Corticosterone	48-62	mitogen-activated protein kinase 1	Homo sapiens	14-17
16581232-11	2007	Since PKC and ERK-MAPK inhibitors attenuate the corticosterone-mediated gene transcription, the above findings suggest that allopregnanolone effect on GR function involves interaction with these kinase pathways.	Corticosterone	48-62	mitogen-activated protein kinase 1	Homo sapiens	18-22
16581232-11	2007	Since PKC and ERK-MAPK inhibitors attenuate the corticosterone-mediated gene transcription, the above findings suggest that allopregnanolone effect on GR function involves interaction with these kinase pathways.	Corticosterone	48-62	nuclear receptor subfamily 3 group C member 1	Homo sapiens	151-153
16581232-14	2007	Furthermore, the inhibitory effect of allopregnanolone on the corticosterone-induced gene transcription in LMCAT cells depended on the inhibition of PKC and ERK-MAPK pathways.	Corticosterone	62-76	mitogen-activated protein kinase 1	Homo sapiens	157-160
16581232-14	2007	Furthermore, the inhibitory effect of allopregnanolone on the corticosterone-induced gene transcription in LMCAT cells depended on the inhibition of PKC and ERK-MAPK pathways.	Corticosterone	62-76	mitogen-activated protein kinase 1	Homo sapiens	161-165
17143559-0	2007	Galanin enhances corticosterone secretion from dispersed rat adrenocortical cells through the activation of GAL-R1 and GAL-R2 receptors coupled to the adenylate cyclase-dependent signaling cascade.	Corticosterone	17-31	galanin receptor 2	Rattus norvegicus	119-125
17021021-1	2007	Previous studies have shown that corticosterone enhances whole cell calcium currents in CA1 pyramidal neurons, through a pathway involving binding of glucocorticoid receptor homodimers to the DNA.	Corticosterone	33-47	carbonic anhydrase 1	Mus musculus	88-91
17021021-1	2007	Previous studies have shown that corticosterone enhances whole cell calcium currents in CA1 pyramidal neurons, through a pathway involving binding of glucocorticoid receptor homodimers to the DNA.	Corticosterone	33-47	nuclear receptor subfamily 3, group C, member 1	Mus musculus	150-173
16973756-3	2007	Activation of PXR by genetic (transgene) or pharmacological (ligand, such as rifampicin) markedly increased plasma concentrations of corticosterone and aldosterone, the respective primary glucocorticoid and mineralocorticoid in rodents.	Corticosterone	133-147	nuclear receptor subfamily 1, group I, member 2	Mus musculus	14-17
18958710-8	2007	Rats were treated with exogenous corticosterone (20 or 30 mg/kg BID) or ethanol (5 g/kg) for either 1 or 4 days.	Corticosterone	33-47	BH3 interacting domain death agonist	Rattus norvegicus	64-67
17161226-12	2007	The ability of TNF(BP) to prevent the sepsis-induced alterations in translation initiation was independent of change in plasma insulin and proportional to the insulinlike growth factor I content in blood and muscle but was associated with a reduction in plasma corticosterone.	Corticosterone	261-275	tumor necrosis factor	Rattus norvegicus	15-18
16973756-4	2007	The increased levels of corticosterone and aldosterone were associated with activation of adrenal steroidogenic enzymes, including cytochrome P450 (CYP)11a1, CYP11b1, CYP11b2, and 3beta-hydroxysteroid dehydrogenase.	Corticosterone	24-38	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	148-156
16973756-4	2007	The increased levels of corticosterone and aldosterone were associated with activation of adrenal steroidogenic enzymes, including cytochrome P450 (CYP)11a1, CYP11b1, CYP11b2, and 3beta-hydroxysteroid dehydrogenase.	Corticosterone	24-38	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	158-165
18287810-8	2007	The median serum corticosterone levels were consistently higher in PRL-deficient mice.	Corticosterone	17-31	prolactin	Mus musculus	67-70
17426391-0	2007	Corticosterone impairs insulin-stimulated translocation of GLUT4 in the rat hippocampus.	Corticosterone	0-14	solute carrier family 2 member 4	Rattus norvegicus	59-64
17426391-6	2007	However, insulin-stimulated phosphorylation of the IR, total Akt levels and total GLUT4 levels were reduced in CORT-treated rats when compared to controls.	Corticosterone	111-115	insulin receptor	Rattus norvegicus	51-53
17426391-6	2007	However, insulin-stimulated phosphorylation of the IR, total Akt levels and total GLUT4 levels were reduced in CORT-treated rats when compared to controls.	Corticosterone	111-115	AKT serine/threonine kinase 1	Rattus norvegicus	61-64
17426391-6	2007	However, insulin-stimulated phosphorylation of the IR, total Akt levels and total GLUT4 levels were reduced in CORT-treated rats when compared to controls.	Corticosterone	111-115	solute carrier family 2 member 4	Rattus norvegicus	82-87
17183555-3	2007	Our objective here was to determine whether corticosterone (CORT) replacement and treatment with the neurogenic compound fluoxetine could reverse behavioral deficits after ADX.	Corticosterone	44-58	cortistatin	Rattus norvegicus	60-64
18287810-9	2007	The implantation of a pituitary graft lowered the corticosterone levels to those observed in PRL-normal mice.	Corticosterone	50-64	prolactin	Mus musculus	93-96
18287810-12	2007	However, the mechanism by which PRL influences bone marrow myeloid cells during stress cannot be explained solely by its effect on serum corticosterone.	Corticosterone	137-151	prolactin	Mus musculus	32-35
17019563-10	2006	These results indicate the inhibitory mechanism of AHA mediates through an inhibition of the activities of the post-cAMP corticosterone synthesis enzymes, i.e. 3beta-HSD, 21-hydroxylase, 11beta-hydroxylase, and inhibition of StAR protein expression.	Corticosterone	121-135	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	160-169
17710249-5	2007	Progressive corticosterone concentrations with predominant action via GR induced strong emotional arousal at the expense of cognitive performance.	Corticosterone	12-26	nuclear receptor subfamily 3, group C, member 1	Mus musculus	70-72
17710250-6	2007	ApoE4, but not mice lacking apoE, or apoE3 mice showed impaired dexamethasone suppression of plasma corticosterone.	Corticosterone	100-114	apolipoprotein E	Homo sapiens	0-5
17713356-2	2007	In this study, we aimed to determine whether receptor antagonists for corticosterone or catecholamines would increase the LPS-induced tumor necrosis factor-alpha (TNF-alpha) response after exhaustive exercise.	Corticosterone	70-84	tumor necrosis factor	Rattus norvegicus	163-172
17030030-0	2006	Cannabinoid CB1 receptor antagonism modulates plasma corticosterone in rodents.	Corticosterone	53-67	cannabinoid receptor 1 (brain)	Mus musculus	12-15
16959842-6	2006	These morphological alterations may be the result of exposure to lower levels of glucocorticoids because plasma corticosterone levels were significantly lower in Igf2-/- mothers compared with wild-type controls.	Corticosterone	112-126	insulin-like growth factor 2	Mus musculus	162-166
16959842-9	2006	This study suggests that Igf2 plays an important role in the development of the fetal lung and may affect fetal lung maturation by regulating maternal factors, such as corticosterone levels, during pregnancy.	Corticosterone	168-182	insulin-like growth factor 2	Mus musculus	25-29
17229084-8	2006	Both doses of corticosterone induced a decrement of NFL, NFM and NFH in both hippocampal areas but only 200 mg decreased MAP2.	Corticosterone	14-28	neurofilament medium chain	Rattus norvegicus	57-60
17229084-8	2006	Both doses of corticosterone induced a decrement of NFL, NFM and NFH in both hippocampal areas but only 200 mg decreased MAP2.	Corticosterone	14-28	neurofilament heavy chain	Rattus norvegicus	65-68
17229084-8	2006	Both doses of corticosterone induced a decrement of NFL, NFM and NFH in both hippocampal areas but only 200 mg decreased MAP2.	Corticosterone	14-28	microtubule-associated protein 2	Rattus norvegicus	121-125
17089014-5	2006	Radioimmune assay showed that the bolus intraperitoneal injection of 2 nmol/100 g NPB or NPW raised the plasma levels of parathyroid hormone, corticosterone and testosterone.	Corticosterone	142-156	neuropeptide B	Rattus norvegicus	82-85
16963002-4	2006	In the median eminence and the ependyma bordering the third ventricule, the DBI gene expression was decreased in ADX rats and a single injection of corticosterone to ADX rats induced a significant increase in DBI gene expression at 3 and 12 h time intervals without completely restoring the basal DBI mRNA expression observed in intact mice.	Corticosterone	148-162	diazepam binding inhibitor	Rattus norvegicus	76-79
16963002-4	2006	In the median eminence and the ependyma bordering the third ventricule, the DBI gene expression was decreased in ADX rats and a single injection of corticosterone to ADX rats induced a significant increase in DBI gene expression at 3 and 12 h time intervals without completely restoring the basal DBI mRNA expression observed in intact mice.	Corticosterone	148-162	diazepam binding inhibitor	Rattus norvegicus	209-212
16963002-4	2006	In the median eminence and the ependyma bordering the third ventricule, the DBI gene expression was decreased in ADX rats and a single injection of corticosterone to ADX rats induced a significant increase in DBI gene expression at 3 and 12 h time intervals without completely restoring the basal DBI mRNA expression observed in intact mice.	Corticosterone	148-162	diazepam binding inhibitor	Rattus norvegicus	209-212
17446698-3	2007	It is generally accepted that GR and MR predominantly reside in the cytoplasm in the absence of corticosterone (CORT), and are quickly translocated into the nucleus upon binding CORT.	Corticosterone	96-110	nuclear receptor subfamily 3 group C member 1	Homo sapiens	30-32
17446698-3	2007	It is generally accepted that GR and MR predominantly reside in the cytoplasm in the absence of corticosterone (CORT), and are quickly translocated into the nucleus upon binding CORT.	Corticosterone	96-110	nuclear receptor subfamily 3 group C member 2	Homo sapiens	37-39
17446698-3	2007	It is generally accepted that GR and MR predominantly reside in the cytoplasm in the absence of corticosterone (CORT), and are quickly translocated into the nucleus upon binding CORT.	Corticosterone	112-116	nuclear receptor subfamily 3 group C member 1	Homo sapiens	30-32
17446698-3	2007	It is generally accepted that GR and MR predominantly reside in the cytoplasm in the absence of corticosterone (CORT), and are quickly translocated into the nucleus upon binding CORT.	Corticosterone	112-116	nuclear receptor subfamily 3 group C member 2	Homo sapiens	37-39
17765729-1	2007	Dentate granule cells are enriched with receptors for the stress hormone corticosterone, i.e., the high-affinity mineralocorticoid receptor (MR), which is already extensively occupied with low levels of the hormone, and the glucocorticoid receptor (GR), which is particularly activated after stress.	Corticosterone	73-87	nuclear receptor subfamily 3 group C member 2	Homo sapiens	113-139
17765729-1	2007	Dentate granule cells are enriched with receptors for the stress hormone corticosterone, i.e., the high-affinity mineralocorticoid receptor (MR), which is already extensively occupied with low levels of the hormone, and the glucocorticoid receptor (GR), which is particularly activated after stress.	Corticosterone	73-87	nuclear receptor subfamily 3 group C member 2	Homo sapiens	141-143
17765729-1	2007	Dentate granule cells are enriched with receptors for the stress hormone corticosterone, i.e., the high-affinity mineralocorticoid receptor (MR), which is already extensively occupied with low levels of the hormone, and the glucocorticoid receptor (GR), which is particularly activated after stress.	Corticosterone	73-87	nuclear receptor subfamily 3 group C member 1	Homo sapiens	249-251
18040815-4	2006	Furthermore, we found that corticosterone does not directly alter the intestinal barrier function; rather, it up-regulates interleukin-18, which then directly or indirectly contributes to impaired intestinal barrier function.	Corticosterone	27-41	interleukin 18	Homo sapiens	123-137
18040816-4	2006	New studies were conducted to further evaluate the role of corticosterone in EtOH-mediated changes in production of interleukin-6 (IL-6), IL-10, and IL-12 in serum and peritoneal fluid in mice treated with poly I:C or lipopolysaccharide (LPS).	Corticosterone	59-73	interleukin 6	Mus musculus	116-129
18040816-5	2006	Suppression of IL-6, but not IL-12, production by EtOH was found to be mediated by corticosterone.	Corticosterone	83-97	interleukin 6	Homo sapiens	15-19
18040816-8	2006	Inhibition of corticosterone synthesis with aminoglutethimide prevented the increase in IL-10 production caused by EtOH plus poly I:C as compared to poly I:C only.	Corticosterone	14-28	interleukin 10	Homo sapiens	88-93
17108082-0	2006	Enhanced anxiety and stress-induced corticosterone release are associated with increased Crh expression in a mouse model of Rett syndrome.	Corticosterone	36-50	corticotropin releasing hormone	Mus musculus	89-92
17108082-3	2006	We studied mice bearing a truncated Mecp2 allele (Mecp2(308/Y) mice) and found evidence of increased anxiety-like behavior and an abnormal stress response as evidenced by elevated serum corticosterone levels.	Corticosterone	186-200	methyl CpG binding protein 2	Mus musculus	36-41
17045988-5	2006	As-POMC (0.05-0.1 nmol/g body weight per day) administered during the same period dose-dependently prevents the increase in body weight, in plasma ir-corticosterone, ir-ACTH, and pituitary ir-ACTH, also preventing the decrease in hypothalamic ir-CRH and ir-ACTH; while the mismatch oligonucleotide is nearly inactive.	Corticosterone	150-164	pro-opiomelanocortin-alpha	Mus musculus	3-7
17192572-3	2006	Prereceptor metabolism of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) amplifies intracellular levels of glucocorticoids by oxoreduction of intrinsically inert cortisone (in humans, 11-dehydrocorticosterone in mice) into active cortisol (corticosterone in mice) within cells expressing the enzyme.	Corticosterone	223-237	RNA, U1 small nuclear 1	Homo sapiens	45-100
17192572-6	2006	In vitro, the 11beta-HSD1 substrate, 11-dehydrocorticosterone, increased macrophage phagocytosis of apoptotic neutrophils to the same extent as corticosterone.	Corticosterone	47-61	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	14-25
17192576-7	2006	TLR-2-deficient mice have an impaired adrenal corticosterone release following inflammatory stress induced by bacterial cell wall compounds.	Corticosterone	46-60	toll-like receptor 2	Mus musculus	0-5
17045951-4	2006	Purified GST-fusion protein form of SULT2 ST2 and SULT2 ST3 exhibited strong sulfating activities toward dehydroepiandrosterone (DHEA) and corticosterone, respectively, among various endogenous compounds tested as substrates.	Corticosterone	139-153	sulfotransferase family 2, cytosolic sulfotransferase 2	Danio rerio	36-45
17045951-4	2006	Purified GST-fusion protein form of SULT2 ST2 and SULT2 ST3 exhibited strong sulfating activities toward dehydroepiandrosterone (DHEA) and corticosterone, respectively, among various endogenous compounds tested as substrates.	Corticosterone	139-153	sulfotransferase family 2, cytosolic sulfotransferase 3	Danio rerio	50-59
17045951-6	2006	Kinetic constants of the two enzymes, as well as the GST-fusion protein form of the previously identified SULT2 ST1, with DHEA and corticosterone as substrates were determined.	Corticosterone	131-145	sulfotransferase family 2, cytosolic sulfotransferase 1	Danio rerio	106-115
16934343-0	2006	Chronically elevated corticosterone in the amygdala increases corticotropin releasing factor mRNA in the dorsolateral bed nucleus of stria terminalis following duress.	Corticosterone	21-35	corticotropin releasing hormone	Homo sapiens	62-92
16934343-2	2006	The current study examined the effect of elevated corticosterone in the amygdala on corticotropin releasing factor (CRF) mRNA levels in the bed nuclei of stria terminalis (BNST).	Corticosterone	50-64	corticotropin releasing hormone	Homo sapiens	84-114
17415471-0	2006	Effect of 5HT2C-receptor agonist MK-212 on blood corticosterone level and behavior in mice.	Corticosterone	49-63	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	10-24
16873540-5	2006	Suppression of hepatic GR expression was correlated with reduced levels of glucose and corresponded to the inhibition of phosphoenolpyruvate carboxykinase mRNA and 11beta-hydroxysteroid dehydrogenase type 1-mediated synthesis of active corticosterone from inactive 11-dehydrocorticosterone in liver.	Corticosterone	236-250	nuclear receptor subfamily 3, group C, member 1	Mus musculus	23-25
16873540-5	2006	Suppression of hepatic GR expression was correlated with reduced levels of glucose and corresponded to the inhibition of phosphoenolpyruvate carboxykinase mRNA and 11beta-hydroxysteroid dehydrogenase type 1-mediated synthesis of active corticosterone from inactive 11-dehydrocorticosterone in liver.	Corticosterone	236-250	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	164-206
16916957-3	2006	Brief exposure of mouse hepatic cells (Hepa 1-6) to corticosterone (CORT) resulted in a significant decrease in mRNA levels of IFN-alpha/beta R1.	Corticosterone	52-66	interferon alpha	Mus musculus	127-136
16916957-3	2006	Brief exposure of mouse hepatic cells (Hepa 1-6) to corticosterone (CORT) resulted in a significant decrease in mRNA levels of IFN-alpha/beta R1.	Corticosterone	52-66	chemokine (C-X-C motif) ligand 11	Mus musculus	137-144
16916957-3	2006	Brief exposure of mouse hepatic cells (Hepa 1-6) to corticosterone (CORT) resulted in a significant decrease in mRNA levels of IFN-alpha/beta R1.	Corticosterone	68-72	interferon alpha	Mus musculus	127-136
16916957-3	2006	Brief exposure of mouse hepatic cells (Hepa 1-6) to corticosterone (CORT) resulted in a significant decrease in mRNA levels of IFN-alpha/beta R1.	Corticosterone	68-72	chemokine (C-X-C motif) ligand 11	Mus musculus	137-144
17088420-3	2006	The NAD+ -dependent isoform (11HSD2) is an oxidase that restrains the effect of hormones due to 11beta-oxidation of cortisol and corticosterone to their 11-oxo derivatives.	Corticosterone	129-143	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	29-35
17026536-4	2006	Reductions in plasma glucose and leptin as well as rapid increases in plasma ghrelin were apparent in the neonate 4 h following maternal deprivation and maximal at 8 h. In addition, maternal separation induced an increase of neuropeptide Y (NPY) mRNA expression in the arcuate nucleus, a decrease of corticotrophin-releasing hormone (CRH) mRNA expression in the paraventricular nucleus and a rise in serum corticosterone.	Corticosterone	406-420	ghrelin	Mus musculus	77-84
17026536-4	2006	Reductions in plasma glucose and leptin as well as rapid increases in plasma ghrelin were apparent in the neonate 4 h following maternal deprivation and maximal at 8 h. In addition, maternal separation induced an increase of neuropeptide Y (NPY) mRNA expression in the arcuate nucleus, a decrease of corticotrophin-releasing hormone (CRH) mRNA expression in the paraventricular nucleus and a rise in serum corticosterone.	Corticosterone	406-420	neuropeptide Y	Mus musculus	225-239
17026536-4	2006	Reductions in plasma glucose and leptin as well as rapid increases in plasma ghrelin were apparent in the neonate 4 h following maternal deprivation and maximal at 8 h. In addition, maternal separation induced an increase of neuropeptide Y (NPY) mRNA expression in the arcuate nucleus, a decrease of corticotrophin-releasing hormone (CRH) mRNA expression in the paraventricular nucleus and a rise in serum corticosterone.	Corticosterone	406-420	neuropeptide Y	Mus musculus	241-244
17026536-6	2006	Thus, the rise in plasma corticosterone induced by maternal separation was ameliorated by prevention of reduction in blood glucose or blockade of the ghrelin signalling pathway, as were the hypothalamic changes in NPY and CRH mRNAs.	Corticosterone	25-39	ghrelin	Mus musculus	150-157
17026537-9	2006	Conversely, hypersecretion of corticosterone at 21 days may underlie synchronous suppression of IL-6 and IFN-gamma.	Corticosterone	30-44	interleukin 6	Rattus norvegicus	96-100
17026537-9	2006	Conversely, hypersecretion of corticosterone at 21 days may underlie synchronous suppression of IL-6 and IFN-gamma.	Corticosterone	30-44	interferon gamma	Rattus norvegicus	105-114
21155263-6	2006	In addition, the levels of supernatant IL-6 and NO were increased clearly in zinc deficiency group and corticosterone stressed groups.	Corticosterone	103-117	interleukin 6	Homo sapiens	39-43
17014691-4	2006	Here we analyzed the effect of tumor necrosis factor-alpha (TNF-alpha) and corticosterone on the transcription of the Aa-nat, hiomt and 14-3-3 protein genes in denervated pineal glands of rats stimulated for 5 hr with norepinephrine, using real-time reverse transcription-polymerase chain reaction.	Corticosterone	75-89	aralkylamine N-acetyltransferase	Rattus norvegicus	118-142
17385428-4	2006	In vitro, 3-week mice had enhanced adrenal sensitivity to ACTH, corticosterone release in response to ACTH, exogenous cAMP and progesterone; and the cAMP level in the cells stimulated with ACTH and forscoline.	Corticosterone	64-78	pro-opiomelanocortin-alpha	Mus musculus	102-106
17385428-4	2006	In vitro, 3-week mice had enhanced adrenal sensitivity to ACTH, corticosterone release in response to ACTH, exogenous cAMP and progesterone; and the cAMP level in the cells stimulated with ACTH and forscoline.	Corticosterone	64-78	pro-opiomelanocortin-alpha	Mus musculus	102-106
17014691-8	2006	In addition, corticosterone induced a potentiation of norepinephrine-induced Aa-nat transcription even after 48 hr of incubation.	Corticosterone	13-27	aralkylamine N-acetyltransferase	Rattus norvegicus	77-83
17107707-5	2006	On the other hand, repeated administration of corticosterone (for 25 days, the final injection 90 min before contextual fear conditioning training) decreased plasma corticosterone concentration, inhibited exploratory behavior, enhanced freezing responses on retest and produced a complex pattern of changes in c-Fos expression, stimulated by exposure of rats to the aversively conditioned context.	Corticosterone	46-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	310-315
17107707-7	2006	In rats chronically treated with corticosterone this effect was attenuated in the mPVN and DG, enhanced in the M1, and additionally observed in the CA1, CA2 layers of the hippocampus, and in the central nucleus of amygdala (CeA), in comparison to control animals not subjected to contextual fear test.	Corticosterone	33-47	carbonic anhydrase 1	Rattus norvegicus	148-151
17107707-7	2006	In rats chronically treated with corticosterone this effect was attenuated in the mPVN and DG, enhanced in the M1, and additionally observed in the CA1, CA2 layers of the hippocampus, and in the central nucleus of amygdala (CeA), in comparison to control animals not subjected to contextual fear test.	Corticosterone	33-47	carbonic anhydrase 2	Rattus norvegicus	153-156
17167538-0	2006	Corticosterone impairs the mRNA expression and activity of 3beta- and 17beta-hydroxysteroid dehydrogenases in adult rat Leydig cells.	Corticosterone	0-14	aldo-keto reductase family 1, member C12	Rattus norvegicus	59-106
17218963-2	2006	In vivo, hepatic 11beta-hydroxysteroid dehydrogenase 1 (HSD1) stimulates the shift of 11-dehydrocorticosterone to corticosterone, enhancing active glucocorticoids at tissue level.	Corticosterone	96-110	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	17-54
17042789-5	2006	Basal circulating corticosterone was increased in Nes-CRHR1 mice compared to controls.	Corticosterone	18-32	nestin	Mus musculus	50-53
17042789-5	2006	Basal circulating corticosterone was increased in Nes-CRHR1 mice compared to controls.	Corticosterone	18-32	corticotropin releasing hormone receptor 1	Mus musculus	54-59
17042789-10	2006	Our results demonstrate that brainstem and/or hypothalamic CRHR1 contribute to the suppression of basal corticosterone secretion in the neonate, while limbic and/or forebrain CRHR1 dampen the activation of the neonatal HPA axis induced by maternal deprivation.	Corticosterone	104-118	corticotropin releasing hormone receptor 1	Mus musculus	59-64
17065401-4	2006	Leptin treatment significantly decreased food intake, body weight, white adipose tissue weight, glucose and insulin plasma contents, and blunted the treadmill running-induced elevation in plasma levels of corticosterone.	Corticosterone	205-219	leptin	Rattus norvegicus	0-6
16784820-1	2006	Nociceptin/orphanin FQ (N/OFQ) is an opioid-related peptide that stimulates corticosterone release after i.c.v.	Corticosterone	76-90	prepronociceptin	Rattus norvegicus	0-10
16784820-1	2006	Nociceptin/orphanin FQ (N/OFQ) is an opioid-related peptide that stimulates corticosterone release after i.c.v.	Corticosterone	76-90	prepronociceptin	Rattus norvegicus	11-22
16836985-7	2006	Consistent with this, stress-induced corticosterone levels were significantly higher in Shn-2(-/-) mice compared to wild-type controls.	Corticosterone	37-51	human immunodeficiency virus type I enhancer binding protein 2	Mus musculus	88-93
16923850-4	2006	We show here that LRH-1 promotes the expression of the steroidogenic enzymes and the synthesis of corticosterone in murine intestinal epithelial cells in vitro.	Corticosterone	98-112	nuclear receptor subfamily 5, group A, member 2	Mus musculus	18-23
17076438-2	2006	The parental roles of prolactin and glucorticoids (corticosterone or cortisol) have many similarities in birds and in mammals.	Corticosterone	51-65	prolactin	Homo sapiens	22-31
16780843-3	2006	The present study was developed to investigate the effects of high-level corticosterone (CORT) post-partum in the mother on postnatal neurogenesis and behavior in the offspring.	Corticosterone	73-87	cortistatin	Homo sapiens	89-93
17033098-12	2006	The carbachol-induced corticosterone response was significantly increased by pretreatment with nNOS inhibitor L-NNA and was considerably reduced by indomethacin, a general COX inhibitor.	Corticosterone	22-36	nitric oxide synthase 1	Rattus norvegicus	95-99
16930567-0	2006	Astrocyte-conditioned medium protecting hippocampal neurons in primary cultures against corticosterone-induced damages via PI3-K/Akt signal pathway.	Corticosterone	88-102	AKT serine/threonine kinase 1	Homo sapiens	129-132
16930567-5	2006	To delineate the molecular basis underlying the neuroprotection of ACM, we assessed the activation of ERK1/2 and (PI3-K)/Akt signal pathways in response to corticosterone-induced neuronal damages.	Corticosterone	156-170	mitogen-activated protein kinase 3	Homo sapiens	102-108
16930567-5	2006	To delineate the molecular basis underlying the neuroprotection of ACM, we assessed the activation of ERK1/2 and (PI3-K)/Akt signal pathways in response to corticosterone-induced neuronal damages.	Corticosterone	156-170	AKT serine/threonine kinase 1	Homo sapiens	121-124
16930567-6	2006	Western blot test revealed that corticosterone increased the phosphorylation of ERK1/2 and PI3-K/Akt in hippocampal neurons grown in Neurobasal medium supplemented with B27 and 500 microm L-glutamine (NBM+).	Corticosterone	32-46	mitogen-activated protein kinase 3	Homo sapiens	80-86
16930567-6	2006	Western blot test revealed that corticosterone increased the phosphorylation of ERK1/2 and PI3-K/Akt in hippocampal neurons grown in Neurobasal medium supplemented with B27 and 500 microm L-glutamine (NBM+).	Corticosterone	32-46	AKT serine/threonine kinase 1	Homo sapiens	97-100
16930567-8	2006	Furthermore, the selective inhibitor of Akt, rather than ERK1/2, blocked the neuroprotective activity against corticosterone in ACM-cultured neurons.	Corticosterone	110-124	AKT serine/threonine kinase 1	Homo sapiens	40-43
16930567-10	2006	PI3-K/Akt signal pathway, but not ERK1/2, was involved in the protective activity against the corticosterone-induced damages.	Corticosterone	94-108	AKT serine/threonine kinase 1	Homo sapiens	6-9
17014730-3	2006	RESULTS: Daytime increases in total WBC and lymphocytes were suppressed and slightly phase-delayed along with plasma corticosterone levels in Clock mutant mice.	Corticosterone	117-131	circadian locomotor output cycles kaput	Mus musculus	142-147
17014730-6	2006	CONCLUSION: Our results suggest that endogenous clock-regulated circadian corticosterone secretion from the adrenal gland is involved in the effect of a Clock mutation on daily profiles of circulating WBC.	Corticosterone	74-88	circadian locomotor output cycles kaput	Mus musculus	48-53
17014730-6	2006	CONCLUSION: Our results suggest that endogenous clock-regulated circadian corticosterone secretion from the adrenal gland is involved in the effect of a Clock mutation on daily profiles of circulating WBC.	Corticosterone	74-88	circadian locomotor output cycles kaput	Mus musculus	153-158
17218963-2	2006	In vivo, hepatic 11beta-hydroxysteroid dehydrogenase 1 (HSD1) stimulates the shift of 11-dehydrocorticosterone to corticosterone, enhancing active glucocorticoids at tissue level.	Corticosterone	96-110	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	56-60
16750196-9	2006	Robust stress responses were evident following TMT exposure as detected by elevated corticosterone (CORT) levels and a significant reduction in exploratory behavior.	Corticosterone	84-98	cortistatin	Rattus norvegicus	100-104
17032740-0	2006	Corticotropin-releasing factor and its receptors in the brain of rats with insulin and corticosterone deficits.	Corticosterone	87-101	corticotropin releasing hormone	Rattus norvegicus	0-30
16980625-4	2006	The absence of CBG resulted in a lack of corticosterone binding activity in serum and in an approximately 10-fold increase in free corticosterone levels in CBG-null mice, consistent with its role in regulation of circulating free hormone levels.	Corticosterone	41-55	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	15-18
16980625-4	2006	The absence of CBG resulted in a lack of corticosterone binding activity in serum and in an approximately 10-fold increase in free corticosterone levels in CBG-null mice, consistent with its role in regulation of circulating free hormone levels.	Corticosterone	131-145	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	15-18
16980625-4	2006	The absence of CBG resulted in a lack of corticosterone binding activity in serum and in an approximately 10-fold increase in free corticosterone levels in CBG-null mice, consistent with its role in regulation of circulating free hormone levels.	Corticosterone	131-145	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	156-159
16876769-0	2006	Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat.	Corticosterone	8-22	brain-derived neurotrophic factor	Rattus norvegicus	33-66
16876769-0	2006	Chronic corticosterone decreases brain-derived neurotrophic factor (BDNF) mRNA and protein in the hippocampus, but not in the frontal cortex, of the rat.	Corticosterone	8-22	brain-derived neurotrophic factor	Rattus norvegicus	68-72
16876769-1	2006	This study examined the effects of chronic corticosterone (32 mg/kg/day, s.c., 21 days) on brain-derived neurotrophic factor (BDNF) mRNA and protein in the frontal cortex and hippocampus of the rat.	Corticosterone	43-57	brain-derived neurotrophic factor	Rattus norvegicus	91-124
16876769-1	2006	This study examined the effects of chronic corticosterone (32 mg/kg/day, s.c., 21 days) on brain-derived neurotrophic factor (BDNF) mRNA and protein in the frontal cortex and hippocampus of the rat.	Corticosterone	43-57	brain-derived neurotrophic factor	Rattus norvegicus	126-130
16876769-3	2006	Corticosterone modestly decreased BDNF protein (-16.6%) in whole hippocampus and BDNF mRNA (-19%) in the CA3 area.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	34-38
16876769-3	2006	Corticosterone modestly decreased BDNF protein (-16.6%) in whole hippocampus and BDNF mRNA (-19%) in the CA3 area.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	81-85
16876769-3	2006	Corticosterone modestly decreased BDNF protein (-16.6%) in whole hippocampus and BDNF mRNA (-19%) in the CA3 area.	Corticosterone	0-14	carbonic anhydrase 3	Rattus norvegicus	105-108
16876769-6	2006	Combined, these data suggests that the effects of corticosterone on the BDNF system are not linked to the effects on the 5-HT systems.	Corticosterone	50-64	brain-derived neurotrophic factor	Rattus norvegicus	72-76
16876769-7	2006	However, our findings do suggest that chronic corticosterone impairs hippocampal BDNF function, a finding with potential relevance for the hippocampal atrophy reported in major depression.	Corticosterone	46-60	brain-derived neurotrophic factor	Rattus norvegicus	81-85
16256304-3	2006	However, we have previously shown that IL-10-/- (IL-10 knockout) mice have higher serum corticosterone levels than IL-10+/+ (wild type) mice following acute immune and physiologic stress, implying that IL-10, an anti-inflammatory cytokine, regulates glucocorticoid synthesis in a negative manner.	Corticosterone	88-102	interleukin 10	Mus musculus	39-44
16256304-3	2006	However, we have previously shown that IL-10-/- (IL-10 knockout) mice have higher serum corticosterone levels than IL-10+/+ (wild type) mice following acute immune and physiologic stress, implying that IL-10, an anti-inflammatory cytokine, regulates glucocorticoid synthesis in a negative manner.	Corticosterone	88-102	interleukin 10	Mus musculus	49-54
16256304-3	2006	However, we have previously shown that IL-10-/- (IL-10 knockout) mice have higher serum corticosterone levels than IL-10+/+ (wild type) mice following acute immune and physiologic stress, implying that IL-10, an anti-inflammatory cytokine, regulates glucocorticoid synthesis in a negative manner.	Corticosterone	88-102	interleukin 10	Mus musculus	49-54
16256304-3	2006	However, we have previously shown that IL-10-/- (IL-10 knockout) mice have higher serum corticosterone levels than IL-10+/+ (wild type) mice following acute immune and physiologic stress, implying that IL-10, an anti-inflammatory cytokine, regulates glucocorticoid synthesis in a negative manner.	Corticosterone	88-102	interleukin 10	Mus musculus	49-54
16256304-4	2006	Here, we show that IL-10 knockout mice produce more corticosterone under basal conditions as well (shown by ELISA).	Corticosterone	52-66	interleukin 10	Mus musculus	19-24
16330180-6	2006	IL-1beta injections resulted in prolonged elevations of microdialysate NE, as well as plasma ACTH and corticosterone, and body temperature.	Corticosterone	102-116	interleukin 1 beta	Rattus norvegicus	0-8
16598785-3	2006	Retinoic acid or 1,25-dihydroxyvitamin D3 enhanced TGF-beta-induced VEGF release in a concentration-dependent manner, whereas dexamethasone or corticosterone suppressed TGF-beta-induced VEGF release.	Corticosterone	143-157	vascular endothelial growth factor A	Homo sapiens	186-190
17033092-0	2006	Imipramine and citalopram reverse corticosterone-induced alterations in the effects of the activation of 5-HT(1A) and 5-HT(2) receptors in rat frontal cortex.	Corticosterone	34-48	5-hydroxytryptamine receptor 1A	Rattus norvegicus	105-112
17033092-3	2006	Repetitive, but not single, corticosterone administration resulted in an attenuation of the effect of the activation of 5-HT(1A) receptors and in an enhancement of the effect related to 5-HT(2) receptors.	Corticosterone	28-42	5-hydroxytryptamine receptor 1A	Rattus norvegicus	120-127
17167538-10	2006	These results suggest that corticosterone might have a direct effect on the transcription of the genes of 3beta- and 17beta-HSD.	Corticosterone	27-41	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	106-127
16806720-21	2006	injection of the endogenous glucocorticoid receptor agonist, corticosterone (1 microg) also had limited diffusion into brain tissue.	Corticosterone	61-75	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	28-51
16906152-5	2006	In mice, the deletion of its gene (Kcnk2, also called TREK-1) led to animals with an increased efficacy of 5-HT neurotransmission and a resistance to depression in five different models and a substantially reduced elevation of corticosterone levels under stress.	Corticosterone	227-241	potassium channel, subfamily K, member 2	Mus musculus	35-40
16906152-5	2006	In mice, the deletion of its gene (Kcnk2, also called TREK-1) led to animals with an increased efficacy of 5-HT neurotransmission and a resistance to depression in five different models and a substantially reduced elevation of corticosterone levels under stress.	Corticosterone	227-241	potassium channel, subfamily K, member 2	Mus musculus	54-60
17060050-0	2006	Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampus.	Corticosterone	16-30	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	49-53
17060050-0	2006	Effect of brief corticosterone administration on SGK1 and RGS4 mRNA expression in rat hippocampus.	Corticosterone	16-30	regulator of G-protein signaling 4	Rattus norvegicus	58-62
17060050-1	2006	Acute stress and corticosterone enhance 5-HT1A receptor-mediated responses in rat hippocampal CA1 cells within 1-2 h, through a process involving transcriptional regulation of unknown genes.	Corticosterone	17-31	5-hydroxytryptamine receptor 1A	Rattus norvegicus	40-46
17060050-1	2006	Acute stress and corticosterone enhance 5-HT1A receptor-mediated responses in rat hippocampal CA1 cells within 1-2 h, through a process involving transcriptional regulation of unknown genes.	Corticosterone	17-31	carbonic anhydrase 1	Rattus norvegicus	94-97
17060050-3	2006	We here tested the hypothesis that corticosterone targets genes encoding RGS4 or SGK1, which can both affect the 5-HT1A receptor associated Kir channel, thus affecting 5-HT1A receptor function.	Corticosterone	35-49	regulator of G-protein signaling 4	Rattus norvegicus	73-77
17060050-3	2006	We here tested the hypothesis that corticosterone targets genes encoding RGS4 or SGK1, which can both affect the 5-HT1A receptor associated Kir channel, thus affecting 5-HT1A receptor function.	Corticosterone	35-49	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	81-85
17060050-3	2006	We here tested the hypothesis that corticosterone targets genes encoding RGS4 or SGK1, which can both affect the 5-HT1A receptor associated Kir channel, thus affecting 5-HT1A receptor function.	Corticosterone	35-49	5-hydroxytryptamine receptor 1A	Rattus norvegicus	113-119
17060050-3	2006	We here tested the hypothesis that corticosterone targets genes encoding RGS4 or SGK1, which can both affect the 5-HT1A receptor associated Kir channel, thus affecting 5-HT1A receptor function.	Corticosterone	35-49	5-hydroxytryptamine receptor 1A	Rattus norvegicus	168-174
17060050-4	2006	To this end, the effect of a single corticosterone injection on hippocampal expression of RGS4 and SGK1 mRNAs, measured by in situ hybridization, was studied.	Corticosterone	36-50	regulator of G-protein signaling 4	Rattus norvegicus	90-94
17060050-4	2006	To this end, the effect of a single corticosterone injection on hippocampal expression of RGS4 and SGK1 mRNAs, measured by in situ hybridization, was studied.	Corticosterone	36-50	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	99-103
17060050-7	2006	We reject, however, the hypothesis that the effect of corticosterone on 5-HT1A responsiveness is mediated via altered RGS4 or SGK1 mRNA expression.	Corticosterone	54-68	5-hydroxytryptamine receptor 1A	Rattus norvegicus	72-78
17060050-7	2006	We reject, however, the hypothesis that the effect of corticosterone on 5-HT1A responsiveness is mediated via altered RGS4 or SGK1 mRNA expression.	Corticosterone	54-68	regulator of G-protein signaling 4	Rattus norvegicus	118-122
17060050-7	2006	We reject, however, the hypothesis that the effect of corticosterone on 5-HT1A responsiveness is mediated via altered RGS4 or SGK1 mRNA expression.	Corticosterone	54-68	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	126-130
16928864-0	2006	Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organic cation transporter 3 in stress-induced modulation of monoaminergic neurotransmission.	Corticosterone	0-14	solute carrier family 22 member 3	Rattus norvegicus	101-129
16928864-12	2006	These data support the hypothesis that corticosterone-induced inhibition of OCT3 mediates stress-induced accumulation of 5-HT in the DMH and suggest that corticosterone may acutely modulate physiological and behavioral responses to stressors by altering serotonergic neurotransmission in this brain region.	Corticosterone	39-53	solute carrier family 22 member 8	Rattus norvegicus	76-80
16219443-4	2006	During fasting, corticosterone levels were higher (P &lt; or = 0.01) in LTF than in STF and AL does, but decreased to control values soon after realimentation.	Corticosterone	16-30	lactotransferrin	Oryctolagus cuniculus	72-75
16872738-7	2006	Arginine vasopressin (AVP), acting through the AVP2 receptor, as well as 11beta-HSD2 substrates, corticosterone and dexamethasone, up-regulate HSD11B2 expression, suggesting their role as possible factors affecting blood pressure.	Corticosterone	97-111	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	73-84
16872738-7	2006	Arginine vasopressin (AVP), acting through the AVP2 receptor, as well as 11beta-HSD2 substrates, corticosterone and dexamethasone, up-regulate HSD11B2 expression, suggesting their role as possible factors affecting blood pressure.	Corticosterone	97-111	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	143-150
16872738-10	2006	The 11beta-HSD2 substrates, both natural (corticosterone) and synthetic (dexamethasone), might protect the mineralocorticosteroid-target cells against cortisol excess.	Corticosterone	42-56	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	4-15
16600311-1	2006	Acute administration of corticosterone (CORT) facilitates learning in a number of associative paradigms including lithium chloride (LiCl)-induced conditioned taste aversion learning.	Corticosterone	24-38	cortistatin	Rattus norvegicus	40-44
16825606-1	2006	Corticosterone and total ghrelin levels are increased in somatostatin (SST) knockout mice (Sst-/-) compared with SST-intact controls (Sst+/+).	Corticosterone	0-14	somatostatin	Mus musculus	71-74
16825606-1	2006	Corticosterone and total ghrelin levels are increased in somatostatin (SST) knockout mice (Sst-/-) compared with SST-intact controls (Sst+/+).	Corticosterone	0-14	somatostatin	Mus musculus	91-94
16675522-8	2006	NPY significantly increased ACTH, corticosterone and oxytocin secretion in the virgins but had no such effect on ACTH or oxytocin in the pregnant rats; the corticosterone response to NPY was markedly attenuated in pregnant rats.	Corticosterone	34-48	neuropeptide Y	Rattus norvegicus	0-3
16675522-8	2006	NPY significantly increased ACTH, corticosterone and oxytocin secretion in the virgins but had no such effect on ACTH or oxytocin in the pregnant rats; the corticosterone response to NPY was markedly attenuated in pregnant rats.	Corticosterone	156-170	neuropeptide Y	Rattus norvegicus	183-186
16730416-6	2006	Plasma corticosterone levels were also significantly increased 30 min after administration of prolactin-releasing peptide.	Corticosterone	7-21	prolactin releasing hormone	Rattus norvegicus	94-121
16899584-6	2006	Concurrent administration of 1-28 POMC and 1-24 ACTH (30 mug/day) resulted in changes identical to 1-24 ACTH treatment alone, which consisted of upregulation of steroidogenic enzymes, elevation of corticosterone levels, hypertrophy of the zona fasciculate, and regression of the X-zone.	Corticosterone	197-211	pro-opiomelanocortin-alpha	Mus musculus	34-38
16899584-7	2006	However, treatment of corticosterone-depleted Pomc(-/-) mice with 1-28 POMC reduced cumulative food intake and total body weight.	Corticosterone	22-36	pro-opiomelanocortin-alpha	Mus musculus	46-50
16899584-7	2006	However, treatment of corticosterone-depleted Pomc(-/-) mice with 1-28 POMC reduced cumulative food intake and total body weight.	Corticosterone	22-36	pro-opiomelanocortin-alpha	Mus musculus	71-75
16867184-0	2006	Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone-induced reduction of adult hippocampal neurogenesis.	Corticosterone	88-102	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	25-48
16899584-8	2006	These anorexigenic effects were ameliorated when the peptide was administered to Pomc(-/-) mice with circulating corticosterone restored either to a low physiological level by corticosterone-supplemented drinking water (CORT) or to a supraphysiological level by concurrent 1-24 ACTH administration.	Corticosterone	113-127	pro-opiomelanocortin-alpha	Mus musculus	81-85
16766084-6	2006	However, the exact conditions and mechanisms are unclear and may involve CART modulation by corticosterone and/or cyclic AMP response element binding protein (CREB).	Corticosterone	92-106	CART prepropeptide	Homo sapiens	73-77
16697078-4	2006	Interestingly, CART expression in these species exhibits a distinctive diurnal rhythm which correlates with the respective daily rhythms of corticosterone and feeding.	Corticosterone	140-154	CART prepropeptide	Rattus norvegicus	15-19
16697078-5	2006	In the rat, adrenalectomy significantly reduces blood CART levels and abolishes its daily rhythm while corticosterone replacement reinstates CART expression to control levels.	Corticosterone	103-117	CART prepropeptide	Rattus norvegicus	141-145
16697078-6	2006	In addition, direct administration of corticosterone significantly increases CART blood levels while administration of corticosterone synthesis blocker metyrapone, inhibits CART blood levels.	Corticosterone	38-52	CART prepropeptide	Rattus norvegicus	77-81
16697078-6	2006	In addition, direct administration of corticosterone significantly increases CART blood levels while administration of corticosterone synthesis blocker metyrapone, inhibits CART blood levels.	Corticosterone	119-133	CART prepropeptide	Rattus norvegicus	173-177
16784727-8	2006	IL-1beta also induced prolonged elevations of hypothalamic microdialysate NE, as well as plasma ACTH and corticosterone.	Corticosterone	105-119	interleukin 1 beta	Rattus norvegicus	0-8
16791107-5	2006	Further, male hippocampal S100B content was negatively correlated with plasma corticosterone levels.	Corticosterone	78-92	S100 calcium binding protein B	Rattus norvegicus	26-31
16449297-5	2006	CRH KO corticosterone was almost undetectable (&lt;1.5 microg/dl) and unresponsive to hypoglycemia.	Corticosterone	7-21	corticotropin releasing hormone	Mus musculus	0-3
16888158-5	2006	Treatment with LPS + PACAP, as compared to LPS, caused TNF-alpha and corticosterone to decrease and T4 to increase after 2 h. These data suggest that PACAP modulates both the endocrine and immune responses in this model of septic shock.	Corticosterone	69-83	adenylate cyclase activating polypeptide 1	Rattus norvegicus	21-26
16888158-5	2006	Treatment with LPS + PACAP, as compared to LPS, caused TNF-alpha and corticosterone to decrease and T4 to increase after 2 h. These data suggest that PACAP modulates both the endocrine and immune responses in this model of septic shock.	Corticosterone	69-83	adenylate cyclase activating polypeptide 1	Rattus norvegicus	150-155
16289758-11	2006	Interestingly, influenza-induced corticosterone secretion was blunted in MSP mice, suggesting that the increase in immune reactivity to the virus was due to lack of glucocorticoid feedback control.	Corticosterone	33-47	kallikrein related-peptidase 6	Mus musculus	73-76
16380238-0	2006	Imipramine treatment ameliorates corticosterone-induced alterations in the effects of 5-HT1A and 5-HT4 receptor activation in the CA1 area of rat hippocampus.	Corticosterone	33-47	5-hydroxytryptamine receptor 1A	Rattus norvegicus	86-92
16380238-0	2006	Imipramine treatment ameliorates corticosterone-induced alterations in the effects of 5-HT1A and 5-HT4 receptor activation in the CA1 area of rat hippocampus.	Corticosterone	33-47	carbonic anhydrase 1	Rattus norvegicus	130-133
16380238-1	2006	This study tested whether imipramine reverses adaptive modifications in the function of hippocampal 5-HT1A and 5-HT4 receptors induced by repetitive administration of corticosterone.	Corticosterone	167-181	5-hydroxytryptamine receptor 1A	Rattus norvegicus	100-106
16380238-7	2006	In the corticosterone plus imipramine group, the effect of 8-OH-DPAT and zacopride were not different from control, indicating that corticosterone-induced adaptive changes in the reactivity of 5-HT1A and 5-HT4 receptors were reversed by imipramine treatment.	Corticosterone	7-21	5-hydroxytryptamine receptor 1A	Rattus norvegicus	193-199
16574115-5	2006	The activity of 20-hydroxysteroid dehydrogenase (20HSD), responsible for the transformation of corticosterone to 20-hydroxy derivatives, was abundant in the kidney and intestine, with lower levels in the liver and testis.	Corticosterone	95-109	carbonyl reductase 3	Gallus gallus	16-47
16574115-5	2006	The activity of 20-hydroxysteroid dehydrogenase (20HSD), responsible for the transformation of corticosterone to 20-hydroxy derivatives, was abundant in the kidney and intestine, with lower levels in the liver and testis.	Corticosterone	95-109	carbonyl reductase 3	Gallus gallus	49-54
16574115-10	2006	Kinetic studies for corticosterone yielded an apparent Km for 11HSD in the nanomolar (Km = 21 +/- 5 nmol.l(-1)) and for 20HSD in the micromolar range (Km = 3.7 +/- 0.3 micromol.l(-1)).	Corticosterone	20-34	carbonyl reductase 3	Gallus gallus	120-125
16717146-2	2006	These MR have an equal affinity for corticosterone that is present in substantially higher concentrations, but are held in reserve for aldosterone by activity of the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD-2), which converts corticosterone to an inactive metabolite.	Corticosterone	247-261	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	173-215
16717146-2	2006	These MR have an equal affinity for corticosterone that is present in substantially higher concentrations, but are held in reserve for aldosterone by activity of the enzyme 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD-2), which converts corticosterone to an inactive metabolite.	Corticosterone	247-261	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	217-229
16785512-8	2006	Coadministration of leptin with LPS blunted endotoxin-induced systemic corticosterone response and production of proinflammatory cytokines.	Corticosterone	71-85	leptin	Mus musculus	20-26
16677622-2	2006	We here tested if corticosterone changes 5-HT(1A) receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT(1A) receptor function.	Corticosterone	18-32	neural cell adhesion molecule 1	Rattus norvegicus	123-127
16677622-2	2006	We here tested if corticosterone changes 5-HT(1A) receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT(1A) receptor function.	Corticosterone	18-32	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	129-133
16677622-2	2006	We here tested if corticosterone changes 5-HT(1A) receptor function indirectly, by altering hippocampal mRNA expression of NCAM, SGK1, or RGS4, which all modulate 5-HT(1A) receptor function.	Corticosterone	18-32	regulator of G-protein signaling 4	Rattus norvegicus	138-142
16707557-0	2006	A novel role for IL-18 in corticosterone-mediated intestinal damage in a two-hit rodent model of alcohol intoxication and injury.	Corticosterone	26-40	interleukin 18	Rattus norvegicus	17-22
16644117-5	2006	In the hippocampus, however, a time-dependent decrease in BDNF mRNA expression (maximal decrease of approximately 73%) is found in all subfields examined 2-7 days after treatment in spite of increased phospho-CREB levels, perhaps as a consequence of corticosterone release by the serotonergic neurotoxin.	Corticosterone	250-264	brain-derived neurotrophic factor	Rattus norvegicus	58-62
16888208-7	2006	The present article suggests that PACAP is involved in the corticosterone release in some pathological conditions but not in the basal state.	Corticosterone	59-73	adenylate cyclase activating polypeptide 1	Mus musculus	34-39
16691441-11	2006	Reduced plasma epinephrine and corticosterone levels and adrenal medullary EGR-1 protein levels in CRH knockout versus WT mice during stress indicate that the HPA axis plays a crucial role in regulation of the PNMT gene expression in these organs.	Corticosterone	31-45	phenylethanolamine-N-methyltransferase	Mus musculus	210-214
16691441-15	2006	Regulation of the PNMT gene expression in various compartments of heart includes both corticosterone-dependent and independent mechanisms.	Corticosterone	86-100	phenylethanolamine-N-methyltransferase	Mus musculus	18-22
16574788-2	2006	Secretion of CRH, ACTH, and corticosterone (CORT) is increased by stimulation of AT(1) receptors.	Corticosterone	28-42	cortistatin	Rattus norvegicus	44-48
16380238-7	2006	In the corticosterone plus imipramine group, the effect of 8-OH-DPAT and zacopride were not different from control, indicating that corticosterone-induced adaptive changes in the reactivity of 5-HT1A and 5-HT4 receptors were reversed by imipramine treatment.	Corticosterone	132-146	5-hydroxytryptamine receptor 1A	Rattus norvegicus	193-199
16505983-10	2006	In conclusion, our study presents first evidence for a link between an altered metabolism in Per1 and Per2 deficient mice, which in the case of the Per1 ( Brd ) animals might be due to an impaired corticosterone rhythm.	Corticosterone	197-211	period circadian clock 2	Mus musculus	102-106
16543369-1	2006	11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) increases intracellular glucocorticoid action by converting inactive to active glucocorticoids (cortisol, corticosterone) within cells.	Corticosterone	163-177	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-42
16543369-1	2006	11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) increases intracellular glucocorticoid action by converting inactive to active glucocorticoids (cortisol, corticosterone) within cells.	Corticosterone	163-177	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	44-55
16556758-1	2006	Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone.	Corticosterone	155-169	neuromedin U	Rattus norvegicus	78-90
16556758-1	2006	Intracerebroventricular (ICV) administration of the hypothalamic neuropeptide neuromedin U (NMU) or the adipostat hormone leptin increases plasma ACTH and corticosterone.	Corticosterone	155-169	neuromedin U	Rattus norvegicus	92-95
16556758-8	2006	The diurnal changes in hypothalamic NMU mRNA expression were positively correlated with hypothalamic NMU peptide content, plasma corticosterone, and plasma leptin.	Corticosterone	129-143	neuromedin U	Rattus norvegicus	36-39
16556758-9	2006	The ICV administration of anti-NMU IgG significantly attenuated the dark phase rise in corticosterone [corticosterone (nanograms per milliliter): vehicle, 493 +/- 38; NMU IgG, 342 +/- 47 (P &lt; 0.05)].	Corticosterone	87-101	neuromedin U	Rattus norvegicus	31-34
16556758-9	2006	The ICV administration of anti-NMU IgG significantly attenuated the dark phase rise in corticosterone [corticosterone (nanograms per milliliter): vehicle, 493 +/- 38; NMU IgG, 342 +/- 47 (P &lt; 0.05)].	Corticosterone	103-117	neuromedin U	Rattus norvegicus	31-34
16685423-2	2006	UII concentration-dependently decreased basal, but not ACTH-stimulated, corticosterone secretion from cultured adrenocortical cells, and the effect was abolished by the UT-R antagonist Palosuran.	Corticosterone	72-86	urotensin 2	Rattus norvegicus	0-3
16555296-6	2006	We show that the staggerer mouse displays an enhanced endocrine response to novelty stress, which is not due to the enhanced production of interleukin-1 (IL-1), insofar as it is not blocked by pretreatment with IL-1ra and lacks the diurnal shift in corticosterone nonstressed levels; this last feature might be related to the expression of RORalpha in the SCN, a structure that maintains the circadian clock and plays a role in timing rhythmic physiology and behavior.	Corticosterone	249-263	RAR-related orphan receptor alpha	Mus musculus	17-26
16237391-5	2006	Over all, mGluR7-/- mice showed only moderately lower serum levels of corticosterone and ACTH compared with mGluR7+/+ mice.	Corticosterone	70-84	glutamate receptor, ionotropic, kainate 3	Mus musculus	10-16
16434144-6	2006	In female offspring, chronic stress significantly increased basal corticosterone (CORT) levels, but not if rats had been exposed to early EE.	Corticosterone	66-80	cortistatin	Rattus norvegicus	82-86
16644010-1	2006	Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain.	Corticosterone	150-164	CART prepropeptide	Rattus norvegicus	92-96
16644010-1	2006	Our previous studies showed the modulation of cocaine and amphetamine regulated transcript (CART) positive neurons and CART mRNA by adrenalectomy and corticosterone replacement in hypothalamic nuclei of male rat brain.	Corticosterone	150-164	CART prepropeptide	Rattus norvegicus	119-123
16721265-7	2006	Circulating levels of corticosterone were markedly reduced in aged LPS-treated IL-6 KO mice relative to aged WT mice given LPS.	Corticosterone	22-36	interleukin 6	Mus musculus	79-83
16707802-4	2006	Here we report that female, but not male, mice lacking urocortin 2 exhibit a significant increase in the basal daily rhythms of ACTH and corticosterone and a significant decrease in fluid intake and depressive-like behavior.	Corticosterone	137-151	urocortin 2	Mus musculus	55-66
16504399-0	2006	Corticosterone regulates expression of CCL2 in the intact and chemically injured hippocampus.	Corticosterone	0-14	C-C motif chemokine ligand 2	Rattus norvegicus	39-43
16504399-4	2006	Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats.	Corticosterone	53-67	cortistatin	Rattus norvegicus	69-73
16504399-4	2006	Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats.	Corticosterone	53-67	C-C motif chemokine ligand 2	Rattus norvegicus	97-101
16504399-4	2006	Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats.	Corticosterone	53-67	C-C motif chemokine receptor 2	Rattus norvegicus	121-125
16504399-4	2006	Here, we explored the effects of the glucocorticoid, corticosterone (CORT), on the expression of CCL2 and its receptors, CCR2 and CCR5, in the hippocampal formation using intact, adrenalectomized (ADX) and trimethyltin (TMT)-treated rats.	Corticosterone	53-67	C-C motif chemokine receptor 5	Rattus norvegicus	130-134
16473474-0	2006	Corticosterone inhibits expression of the microglial glutamate transporter GLT-1 in vitro.	Corticosterone	0-14	solute carrier family 1 member 3	Rattus norvegicus	53-74
16473474-0	2006	Corticosterone inhibits expression of the microglial glutamate transporter GLT-1 in vitro.	Corticosterone	0-14	solute carrier family 1 member 2	Rattus norvegicus	75-80
16473474-5	2006	Corticosterone also inhibited the lipopolysaccharide-induced increase of the GLT-1 expression as well as the expression in non-activated cells.	Corticosterone	0-14	solute carrier family 1 member 2	Rattus norvegicus	77-82
16473474-6	2006	The effect of corticosterone on the GLT-1 expression was dose dependent and accompanied by similar effects on the microglial glutamate uptake capacity.	Corticosterone	14-28	solute carrier family 1 member 2	Rattus norvegicus	36-41
16473474-7	2006	Additionally, exogenous tumor necrosis factor-alpha was found to counteract the effect of corticosterone on microglial GLT-1 expression.	Corticosterone	90-104	tumor necrosis factor	Rattus norvegicus	24-51
16473474-7	2006	Additionally, exogenous tumor necrosis factor-alpha was found to counteract the effect of corticosterone on microglial GLT-1 expression.	Corticosterone	90-104	solute carrier family 1 member 2	Rattus norvegicus	119-124
16473474-9	2006	Thus, corticosterone decreased the microglial uptake of glutamate by decreasing the expression of glutamate transporters, probably due to the inhibited microglial tumor necrosis factor-alpha release.	Corticosterone	6-20	tumor necrosis factor	Rattus norvegicus	163-190
16368783-0	2006	Attenuated corticosterone response to chronic ACTH stimulation in hepatic lipase-deficient mice: evidence for a role for hepatic lipase in adrenal physiology.	Corticosterone	11-25	pro-opiomelanocortin-alpha	Mus musculus	46-50
16197924-3	2006	RESULTS: Despite normal basal levels of corticosterone, the adult offspring of mothers given DEX or CORT displayed abnormal responses in the dexamethasone-suppression test.	Corticosterone	40-54	cortistatin	Rattus norvegicus	100-104
16817877-12	2006	Twenty-four hour SI elevated plasma corticosterone (CORT) to levels previously shown to enhance LTP (125 ng/mL).	Corticosterone	36-50	cortistatin	Rattus norvegicus	52-56
16546708-6	2006	In the ES group, elevated plasma corticosterone concentration was associated with immunosuppression and a significant decrease in plasma concentrations of IL-2, IL-4, and TGF-beta1.	Corticosterone	33-47	interleukin 2	Mus musculus	155-159
16712723-1	2006	BACKGROUND: Corticosterone reduction produced by adrenalectomy (ADX) induces apoptosis in dentate gyrus (DG) of the hippocampus, an effect related to an increase in the expression of the pro-apoptotic gene bax.	Corticosterone	12-26	BCL2 associated X, apoptosis regulator	Rattus norvegicus	206-209
16546708-6	2006	In the ES group, elevated plasma corticosterone concentration was associated with immunosuppression and a significant decrease in plasma concentrations of IL-2, IL-4, and TGF-beta1.	Corticosterone	33-47	interleukin 4	Mus musculus	161-165
16546708-6	2006	In the ES group, elevated plasma corticosterone concentration was associated with immunosuppression and a significant decrease in plasma concentrations of IL-2, IL-4, and TGF-beta1.	Corticosterone	33-47	transforming growth factor, beta 1	Mus musculus	171-180
16436475-5	2006	Cells expressing alphabeta4 exhibited potent, rapid, reversible, and dose-dependent potentiation by corticosterone (CORT; a glucocorticoid), and were potentiated to a lesser degree by other sex and stress steroids.	Corticosterone	100-114	cortistatin	Homo sapiens	116-120
16530273-14	2006	Age and hormone effects on pituitary cytokines were also mirrored in plasma corticosterone (CORT) levels, such that estrogen treatment to senescent females attenuated LPS-induced CORT.	Corticosterone	76-90	cortistatin	Rattus norvegicus	92-96
16530273-14	2006	Age and hormone effects on pituitary cytokines were also mirrored in plasma corticosterone (CORT) levels, such that estrogen treatment to senescent females attenuated LPS-induced CORT.	Corticosterone	76-90	cortistatin	Rattus norvegicus	179-183
16869285-8	2006	The ACTH-induced corticosterone production in 3-week- old Ay/a-m/CQ was lower and in 15-week old Ay/a-mice was higher than in a/a-mice of the respective ages.	Corticosterone	17-31	pro-opiomelanocortin-alpha	Mus musculus	4-8
16606831-6	2006	In the present work, by using a low dose of LPS to mimic systemic inflammatory response syndrome, we have revealed marked cellular alterations in adrenocortical tissue and an impaired adrenal corticosterone response in TLR-4-/- mice.	Corticosterone	192-206	toll-like receptor 4	Mus musculus	219-224
16545343-6	2006	Both CRF and corticosterone are released during stress and are known to increase CRF-BP in vitro.	Corticosterone	13-27	corticotropin releasing hormone binding protein	Rattus norvegicus	81-87
16545343-8	2006	Therefore, we examined the effects of CRF and corticosterone administration on BLA CRF-BP mRNA in rats.	Corticosterone	46-60	corticotropin releasing hormone binding protein	Rattus norvegicus	83-89
16510135-0	2006	A 24 h corticosterone exposure exacerbates excitotoxic insult in rat hippocampal slice cultures independently of glucocorticoid receptor activation or protein synthesis.	Corticosterone	7-21	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	113-136
16533503-8	2006	Cardiomyocyte hypertrophy led to a significant 2-fold increase in glucocorticoid receptor and mineralocorticoid receptor expression that resulted in enhanced receptor signaling as judged via the ability of corticosterone and aldosterone to induce SGK1 gene transcription.	Corticosterone	206-220	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	66-89
16533503-8	2006	Cardiomyocyte hypertrophy led to a significant 2-fold increase in glucocorticoid receptor and mineralocorticoid receptor expression that resulted in enhanced receptor signaling as judged via the ability of corticosterone and aldosterone to induce SGK1 gene transcription.	Corticosterone	206-220	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	94-120
16533503-8	2006	Cardiomyocyte hypertrophy led to a significant 2-fold increase in glucocorticoid receptor and mineralocorticoid receptor expression that resulted in enhanced receptor signaling as judged via the ability of corticosterone and aldosterone to induce SGK1 gene transcription.	Corticosterone	206-220	serum/glucocorticoid regulated kinase 1	Rattus norvegicus	247-251
16533503-11	2006	In basal cardiomyocytes, either aldosterone or corticosterone induced only a minor increase in ANP mRNA and protein synthesis; however, in cardiomyocytes primed with phenylephrine, both corticosteroids significantly potentiated phenylephrine-mediated effects via activation of the glucocorticoid receptor.	Corticosterone	47-61	natriuretic peptide A	Rattus norvegicus	95-98
16533503-11	2006	In basal cardiomyocytes, either aldosterone or corticosterone induced only a minor increase in ANP mRNA and protein synthesis; however, in cardiomyocytes primed with phenylephrine, both corticosteroids significantly potentiated phenylephrine-mediated effects via activation of the glucocorticoid receptor.	Corticosterone	47-61	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	281-304
16608531-9	2006	Corticosterone (1 microM) significantly reduced 5-HT-induced bronchoconstriction in wild-type and OCT1/2 double-knockout mice, but not in OCT3 knockout mice.	Corticosterone	0-14	solute carrier family 22 (organic cation transporter), member 1	Mus musculus	98-104
16386319-2	2006	We have recently shown that repeated corticosterone (CORT) injections reliably increase depression-like behavior on the forced-swim test in rats, suggesting that glucocorticoids can precipitate depressive symptomatology.	Corticosterone	37-51	cortistatin	Rattus norvegicus	53-57
16608531-14	2006	Instead, this activity involves 1) a non-cholinergic epithelium-dependent component, and 2) direct stimulation of bronchial smooth muscle cells, a response which is partly sensitive to acutely administered corticosterone acting on OCT3.	Corticosterone	206-220	solute carrier family 22 (organic cation transporter), member 3	Mus musculus	231-235
16484905-9	2006	Corticosterone after 10 ng/kg ACTH in the pm decreased as plasma macrophage migration inhibitory factor and IL-6 increased after CLP (r = -.691 and r = -.813, respectively; p &lt; .02 in each case).	Corticosterone	0-14	interleukin 6	Rattus norvegicus	108-112
16239608-10	2006	IL-6 was elevated, whereas IL-12p40 levels were decreased below baseline at 24 h. Corticosterone positively correlated with IL-6, increasing from T(c,Max) to hypothermia, with recovery to baseline by 24 h. Tissue lesions were observed in duodenum, spleen, and kidney at T(c,Max), hypothermia, and 24 h, respectively.	Corticosterone	82-96	interleukin 6	Mus musculus	124-128
16785605-1	2006	Reduction in corticosterone by acute adrenalectomy (5 d) promotes apoptosis in dentate gyrus (DG) granular neurons, an effect concomitant with variations in the expression of the Bcl-2 gene family implicated in apoptotic regulation.	Corticosterone	13-27	BCL2, apoptosis regulator	Rattus norvegicus	179-184
16503919-5	2006	To activate GR, slices were treated in vitro with a high (100 nM) dose of corticosterone and gene expression was profiled 1, 3 and 5 h after GR-activation.	Corticosterone	74-88	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	12-14
16514009-2	2006	Corticosterone actions in the brain are mediated by two corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and they show a high degree of colocalization in the hippocampal region.	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	82-105
16497715-8	2006	MPR increased maternal progesterone, corticosterone, oestradiol and testosterone concentrations at 19 days gestation.	Corticosterone	37-51	progesterone receptor membrane component 1	Rattus norvegicus	0-3
16514009-2	2006	Corticosterone actions in the brain are mediated by two corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and they show a high degree of colocalization in the hippocampal region.	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	107-109
16514009-2	2006	Corticosterone actions in the brain are mediated by two corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and they show a high degree of colocalization in the hippocampal region.	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 2	Homo sapiens	115-141
16514009-2	2006	Corticosterone actions in the brain are mediated by two corticosteroid receptors, glucocorticoid receptor (GR) and mineralocorticoid receptor (MR), and they show a high degree of colocalization in the hippocampal region.	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 2	Homo sapiens	143-145
16326007-0	2006	Chronic corticosterone manipulations in mice affect brain cell proliferation rates, but only partly affect BDNF protein levels.	Corticosterone	8-22	brain derived neurotrophic factor	Mus musculus	107-111
16673181-2	2006	This study examined changes in glucocorticoid receptor (GR) and glutamine synthetase (GS) expression in rat skeletal muscle in relation to plasma CS over a 24-h period.	Corticosterone	146-148	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	31-54
16673181-2	2006	This study examined changes in glucocorticoid receptor (GR) and glutamine synthetase (GS) expression in rat skeletal muscle in relation to plasma CS over a 24-h period.	Corticosterone	146-148	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	56-58
16326007-1	2006	We investigated whether the effects of corticosterone (CORT) on brain cell proliferation are mediated via its detrimental effect on brain-derived neurotrophic factor (BDNF).	Corticosterone	39-53	cortistatin	Mus musculus	55-59
16290283-10	2006	In addition, we also found that CMS alone increased circulating corticosterone (CORT) significantly and decreased hippocampal glucocorticoid receptor (GR) mRNA.	Corticosterone	64-78	cortistatin	Rattus norvegicus	80-84
16339206-5	2006	However, after exposure to paradigms of acute and chronic stress, SRC-1-/- mice exhibited an elevation in serum corticosterone despite normal (nonsuppressed) ACTH, suggesting an increase in adrenal sensitivity as well as a concomitant defect in glucocorticoid-mediated feedback inhibition of the HPA axis.	Corticosterone	112-126	nuclear receptor coactivator 1	Mus musculus	66-71
16546708-11	2006	These results suggest that corticosterone mediates the immunosuppression induced by HPA axis activation, and induces dysregulation of the Th1/Th2 cytokine profile.	Corticosterone	27-41	negative elongation factor complex member C/D, Th1l	Mus musculus	138-141
16546708-11	2006	These results suggest that corticosterone mediates the immunosuppression induced by HPA axis activation, and induces dysregulation of the Th1/Th2 cytokine profile.	Corticosterone	27-41	heart and neural crest derivatives expressed 2	Mus musculus	142-145
16405651-0	2006	Direct effects of IL-15 on corticosterone secretion by rat adrenocortical cells.	Corticosterone	27-41	interleukin 15	Rattus norvegicus	18-23
16413106-4	2006	11Beta-HSD1 regenerates active glucocorticoids from their inactive 11-keto derivatives, hence boosting tissue levels of corticosterone and cortisol.	Corticosterone	120-134	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-11
16413106-5	2006	Removal of this enzyme (11beta-HSD1-/- mice) results in apparent lower intra-hippocampal corticosterone levels and reduces glucocorticoid-associated cognitive decline during ageing.	Corticosterone	89-103	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	24-35
16413106-8	2006	11Beta-HSD2 acts as a dehydrogenase, inactivating corticosterone or cortisol through conversion to 11-dehydrocorticosterone and cortisone.	Corticosterone	50-64	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-11
16547165-3	2006	Here we demonstrate that corticosterone rapidly facilitates synaptic potentiation in the mouse hippocampal CA1 area when high levels of the hormone and high-frequency stimulation coincide in time, but not when corticosterone is given either before or after repetitive stimulation.	Corticosterone	25-39	carbonic anhydrase 1	Mus musculus	107-110
16416158-0	2006	Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse.	Corticosterone	26-40	leukemia inhibitory factor	Mus musculus	89-115
16416158-0	2006	Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse.	Corticosterone	26-40	leukemia inhibitory factor	Mus musculus	117-120
16416158-0	2006	Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse.	Corticosterone	26-40	corticotropin releasing hormone	Mus musculus	126-157
16416158-0	2006	Developmental exposure to corticosterone: behavioral changes and differential effects on leukemia inhibitory factor (LIF) and corticotropin-releasing hormone (CRH) gene expression in the mouse.	Corticosterone	26-40	corticotropin releasing hormone	Mus musculus	159-162
16210420-8	2006	Both intraperitoneal and intracerebroventricular administration of leptin decreased serum corticosterone significantly (P &lt; 0.05).	Corticosterone	90-104	leptin	Rattus norvegicus	67-73
15990099-1	2006	The purpose of this study was to determine the effects of different food-reinforcement schedules on plasma corticosterone (CORT), and its possible involvement in the acquisition and maintenance of schedule-induced polydipsia (SIP).	Corticosterone	107-121	cortistatin	Rattus norvegicus	123-127
16405651-4	2006	In vitro experiments were designed to assess the direct effect of IL-15 on corticosterone (CORT) secretion in the adrenal zona fasciculata-reticularis (ZFR) cells of male rats.	Corticosterone	75-89	interleukin 15	Rattus norvegicus	66-71
16405651-4	2006	In vitro experiments were designed to assess the direct effect of IL-15 on corticosterone (CORT) secretion in the adrenal zona fasciculata-reticularis (ZFR) cells of male rats.	Corticosterone	75-89	cortistatin	Rattus norvegicus	91-95
16175571-10	2006	These results indicated that DG and DT have an inhibitory effect on corticosterone production via a Na+, K+-ATPase-independent mechanism by diminishing actions on cAMP-, Ca2+-pathway, competitive inhibition of P450scc enzyme and reduction of StAR mRNA expression.	Corticosterone	68-82	steroidogenic acute regulatory protein	Rattus norvegicus	242-246
16420279-0	2006	Corticosterone actions on the hippocampal brain-derived neurotrophic factor expression are mediated by exon IV promoter.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	42-75
16440060-2	2006	To elucidate these roles, we introduced a POMC transgene (Tg) that selectively restored peripheral melanocortin and corticosterone secretion in Pomc mice.	Corticosterone	116-130	pro-opiomelanocortin-alpha	Mus musculus	42-46
16440060-5	2006	Replacement of corticosterone in the drinking water of Pomc mice recapitulated the hyperphagia, excess weight gain and fat accumulation, and hyperleptinemia characteristic of genetically rescued PomcTg mice.	Corticosterone	15-29	pro-opiomelanocortin-alpha	Mus musculus	55-59
16278020-7	2006	This proliferation was a function of corticosterone-induced activation of the N-methyl-D-aspartate (NMDA) receptor within the CNS since blockade of corticosterone synthesis, the glucocorticoid receptor, or the NMDA receptor each prevented stress-induced increases in microglia number.	Corticosterone	37-51	nuclear receptor subfamily 3, group C, member 1	Mus musculus	178-201
16420279-3	2006	In adrenalectomised rats, corticosterone (10 mg/kg s.c.) induces a robust down-regulation of both BDNF mRNA and protein levels in the hippocampus peaking at 2-8 h. To study the role of the individual promoters in the corticosterone response, we employed exon-specific riboprobe in situ hybridisation as well as real-time polymerase chain reaction (PCR) in the dentate gyrus.	Corticosterone	26-40	brain-derived neurotrophic factor	Rattus norvegicus	98-102
16420279-7	2006	It appears as if the exon IV promoter is the major target for corticosterone-mediated transcriptional regulation of BDNF in the hippocampus.	Corticosterone	62-76	brain-derived neurotrophic factor	Rattus norvegicus	116-120
16293347-0	2006	Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone.	Corticosterone	91-105	thyrotropin releasing hormone	Rattus norvegicus	20-23
16452668-6	2006	Compared with controls, E2 and the ERalpha-selective agonists moxestrol and propyl-pyrazole-triol significantly increased the stress induced release of corticosterone and ACTH.	Corticosterone	152-166	estrogen receptor 1	Rattus norvegicus	35-42
16452668-7	2006	In contrast, central administration of DHT, 3beta-diol, and the ERbeta-selective compound diarylpropionitrile significantly decreased the corticosterone and ACTH response to immobilization.	Corticosterone	138-152	estrogen receptor 2	Rattus norvegicus	64-70
16293664-8	2006	In addition, the immunoreactivity of cyclooxygenase-2, a PG-synthesizing enzyme, in the brain under stress conditions was much enhanced by ADX, and this was counteracted by corticosterone treatment.	Corticosterone	173-187	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	37-53
16293347-0	2006	Rapid modulation of TRH and TRH-like peptide levels in rat brain and peripheral tissues by corticosterone.	Corticosterone	91-105	thyrotropin releasing hormone	Rattus norvegicus	28-31
16293347-7	2006	Significant increases, ranging from 2- to 12-fold, in TRH or TRH-like peptide levels were observed in almost all brain regions studied at 4h after corticosterone injection.	Corticosterone	147-161	thyrotropin releasing hormone	Rattus norvegicus	54-57
16293347-7	2006	Significant increases, ranging from 2- to 12-fold, in TRH or TRH-like peptide levels were observed in almost all brain regions studied at 4h after corticosterone injection.	Corticosterone	147-161	thyrotropin releasing hormone	Rattus norvegicus	61-64
16293347-13	2006	The 4h needed to detect a highly significant change in the TRH and TRH-like peptide levels in brain and peripheral tissues is consistent with the mediation of most corticosterone-effects via alterations in gene transcription.	Corticosterone	164-178	thyrotropin releasing hormone	Rattus norvegicus	59-62
16293347-13	2006	The 4h needed to detect a highly significant change in the TRH and TRH-like peptide levels in brain and peripheral tissues is consistent with the mediation of most corticosterone-effects via alterations in gene transcription.	Corticosterone	164-178	thyrotropin releasing hormone	Rattus norvegicus	67-70
16648774-6	2006	However, CART stimulated corticosterone release at 10, 30, 60 min after icv injection.	Corticosterone	25-39	CART prepropeptide	Rattus norvegicus	9-13
16648774-7	2006	CONCLUSIONS: CART (55-102) administered intracerebroventricularly (icv) stimulated ACTH and corticosterone release.	Corticosterone	92-106	CART prepropeptide	Rattus norvegicus	13-17
16289840-1	2006	11beta-Hydroxysteroid dehydrogenase type 2 is a glucocorticoid metabolizing enzyme that catalyzes rapid inactivation of corticosterone and cortisol to inert 11-keto derivatives.	Corticosterone	120-134	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	0-42
16338462-0	2006	Corticosterone transfer and metabolism in the dually perfused rat placenta: effect of 11beta-hydroxysteroid dehydrogenase type 2.	Corticosterone	0-14	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	86-128
16289840-6	2006	When exogenous corticosterone was administered to the pups between postnatal days 4 and 13, 11beta-hydroxysteroid dehydrogenase type 2(-/-) mice were more sensitive, showing further inhibition of cerebellar growth while the wildtype mice were not affected.	Corticosterone	15-29	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	92-134
16338462-1	2006	Although rat is the most widely used model of glucocorticoid programming of the fetus, the role of rat placental 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) in the transplacental pharmacokinetics of the naturally occurring glucocorticoid, corticosterone, has not yet been fully elucidated.	Corticosterone	252-266	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	157-168
16338462-2	2006	In this study, expression of 11beta-HSD2 in the rat placenta on two different gestation days (16 and 22) was examined using quantitative RT-PCR and Western blotting, and dually perfused rat term placenta was employed to evaluate its functional capacity to transfer and metabolize corticosterone.	Corticosterone	280-294	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	29-40
16338462-4	2006	In perfusion studies, increasing maternal corticosterone concentration from 3 to 200 nM resulted in the fall of 11beta-HSD2 conversion capacity from 64.3 to 16.3%, respectively.	Corticosterone	42-56	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	112-123
16338462-6	2006	When delivering corticosterone (3 or 100 nM) from the fetal side, a similar decline of 11beta-HSD2 conversion capacity was observed (66.5% and 48.5%, respectively).	Corticosterone	16-30	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	87-98
16338462-10	2006	These data suggest that 11beta-HSD2 is the principal enzyme controlling transplacental passage of corticosterone in rats and is able to eliminate corticosterone in both maternal and fetal circulations.	Corticosterone	98-112	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	24-35
16338462-10	2006	These data suggest that 11beta-HSD2 is the principal enzyme controlling transplacental passage of corticosterone in rats and is able to eliminate corticosterone in both maternal and fetal circulations.	Corticosterone	146-160	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	24-35
16234247-2	2006	11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) catalyzes the interconversion of biologically inactive 11 keto derivatives (cortisone, 11-dehydrocorticosterone) to active glucocorticoids (cortisol, corticosterone) in fat, liver, and other tissues.	Corticosterone	156-170	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	0-57
16112493-1	2006	The effect of a lack of the gene encoding monoamine oxidase A (MAO A) in transgenic Tg 8 mice on the corticosterone response to restraint, cold, water deprivation-induced, or social acute stress as well as chronic variable stress was studied.	Corticosterone	101-115	monoamine oxidase A	Mus musculus	42-61
16112493-2	2006	It was found that Tg 8 mice with genetic MAO A knockout and wild-type C3H/HeJ (C3H) strain showed similar plasma corticosterone resting level.	Corticosterone	113-127	monoamine oxidase A	Mus musculus	41-46
16212963-11	2006	Rat and eel ANP and rat and chicken brain natriuretic peptide (BNP) were equally efficacious at inhibiting maximal ANG II-induced aldosterone and corticosterone production but with different potencies.	Corticosterone	146-160	natriuretic peptide B	Rattus norvegicus	63-66
16212963-11	2006	Rat and eel ANP and rat and chicken brain natriuretic peptide (BNP) were equally efficacious at inhibiting maximal ANG II-induced aldosterone and corticosterone production but with different potencies.	Corticosterone	146-160	angiotensinogen	Rattus norvegicus	115-121
16699257-7	2006	Serum corticosterone levels were, however, reduced and correlated with increased mRNA levels of renal 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2) and decreased mRNA expression of 11beta-hydroxylase in the adrenal gland of dDAVP-injected rats.	Corticosterone	6-20	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	102-139
16360124-4	2006	The mCPP-induced increase in the serum concentration of corticosterone was not blocked by the 5-HT2C antagonist SB242084, but was blocked by the 5-HT2A antagonist ketanserin.	Corticosterone	56-70	5-hydroxytryptamine receptor 2A	Rattus norvegicus	145-151
16699257-7	2006	Serum corticosterone levels were, however, reduced and correlated with increased mRNA levels of renal 11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2) and decreased mRNA expression of 11beta-hydroxylase in the adrenal gland of dDAVP-injected rats.	Corticosterone	6-20	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	141-152
16377222-6	2006	First, we determined plasma corticosterone (CORT) concentrations after intracerebroventricular (ICV) injection of GLP-1 and found that this treatment increased CORT release in layer chicks.	Corticosterone	28-42	glucagon	Gallus gallus	114-119
16377222-6	2006	First, we determined plasma corticosterone (CORT) concentrations after intracerebroventricular (ICV) injection of GLP-1 and found that this treatment increased CORT release in layer chicks.	Corticosterone	44-48	glucagon	Gallus gallus	114-119
16200643-11	2006	An assessment of plasma levels of corticosterone (CORT), following the behavioral procedures, revealed an enhancement in CORT release following the uncontrollable, but not controllable stress, indicating the uncontrollable condition as the most stressful.	Corticosterone	34-48	cortistatin	Rattus norvegicus	50-54
16808795-4	2006	The plasma levels of corticosterone (CORT) and adrenocorticotropic hormone (ACTH) were detected by radioimmunoassay at different time points.	Corticosterone	21-35	cortistatin	Rattus norvegicus	37-41
16200643-11	2006	An assessment of plasma levels of corticosterone (CORT), following the behavioral procedures, revealed an enhancement in CORT release following the uncontrollable, but not controllable stress, indicating the uncontrollable condition as the most stressful.	Corticosterone	34-48	cortistatin	Rattus norvegicus	121-125
17183192-8	2006	Moreover, corticosterone excess reduces LPS-induced production of NT mRNA in the PVN.	Corticosterone	10-24	neurotensin	Rattus norvegicus	66-68
16394174-2	2006	An intracerebroventricular administration of NPW increased serum prolactin and corticosterone concentrations, decreased dark-phase feeding, raised energy expenditure, and lowered body weight.	Corticosterone	79-93	neuropeptide W	Rattus norvegicus	45-48
17047394-3	2006	OBJECTIVES: To determine the relationships between induction of COX-2 in the brain with IL-1beta- and LPS-induced changes in body temperature, plasma corticosterone and feeding.	Corticosterone	150-164	cytochrome c oxidase II, mitochondrial	Mus musculus	64-69
17047394-5	2006	The induction of COX-2 was studied immunocytochemically in the brain, in parallel with core body temperature, the drinking of sweetened milk, and plasma concentrations of corticosterone.	Corticosterone	171-185	cytochrome c oxidase II, mitochondrial	Mus musculus	17-22
17047394-12	2006	The time courses of the IL-1- and LPS-induced increases in plasma corticosterone paralleled those in the reduction in milk drinking, however, the changes in body temperature appeared later.	Corticosterone	66-80	interleukin 1 complex	Mus musculus	24-28
16500030-0	2006	Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone.	Corticosterone	24-38	brain-derived neurotrophic factor	Rattus norvegicus	60-93
16500030-0	2006	Antidepressants reverse corticosterone-mediated decrease in brain-derived neurotrophic factor expression: differential regulation of specific exons by antidepressants and corticosterone.	Corticosterone	171-185	brain-derived neurotrophic factor	Rattus norvegicus	60-93
16500030-2	2006	It has been shown that antidepressants upregulate, whereas corticosterone downregulates, brain-derived neurotrophic factor expression in rat brain.	Corticosterone	59-73	brain-derived neurotrophic factor	Rattus norvegicus	89-122
16500030-3	2006	Whether various classes of antidepressants reverse corticosterone-mediated downregulation of brain-derived neurotrophic factor is unclear.	Corticosterone	51-65	brain-derived neurotrophic factor	Rattus norvegicus	93-126
16500030-4	2006	Also not known is how antidepressants or corticosterone regulates brain-derived neurotrophic factor expression.	Corticosterone	41-55	brain-derived neurotrophic factor	Rattus norvegicus	66-99
16500030-5	2006	To clarify this, we examined the effects of various classes of antidepressants and corticosterone, alone and in combination, on the mRNA expression of total brain-derived neurotrophic factor and of individual brain-derived neurotrophic factor exons, in rat brain.	Corticosterone	83-97	brain-derived neurotrophic factor	Rattus norvegicus	157-190
16500030-5	2006	To clarify this, we examined the effects of various classes of antidepressants and corticosterone, alone and in combination, on the mRNA expression of total brain-derived neurotrophic factor and of individual brain-derived neurotrophic factor exons, in rat brain.	Corticosterone	83-97	brain-derived neurotrophic factor	Rattus norvegicus	209-242
16500030-11	2006	Corticosterone treatment of normal rats decreased expression of total brain-derived neurotrophic factor mRNA in both brain areas, specifically decreasing exons II and IV.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	70-103
16453979-9	2006	CONCLUSIONS: These data suggest that glucocorticoid-receptor activation by corticosterone participates in the antidepressant-like adaptive changes in 5-HT1A autoreceptors in sleep-deprived mice.	Corticosterone	75-89	nuclear receptor subfamily 3, group C, member 1	Mus musculus	37-60
16500030-12	2006	Treatment with desipramine or phenelzine of corticosterone pellet-implanted rats reversed the corticosterone-induced decrease in total brain-derived neurotrophic factor expression in both brain areas; however, fluoxetine reversed the decrease only partially in hippocampus.	Corticosterone	44-58	brain-derived neurotrophic factor	Rattus norvegicus	135-168
16500030-12	2006	Treatment with desipramine or phenelzine of corticosterone pellet-implanted rats reversed the corticosterone-induced decrease in total brain-derived neurotrophic factor expression in both brain areas; however, fluoxetine reversed the decrease only partially in hippocampus.	Corticosterone	94-108	brain-derived neurotrophic factor	Rattus norvegicus	135-168
16500030-14	2006	We found that although corticosterone and antidepressants both modulate brain-derived neurotrophic factor expression, and antidepressants reverse the corticosterone-induced brain-derived neurotrophic factor decrease, antidepressants and corticosterone differ in how they regulate the expression of brain-derived neurotrophic factor exon(s).	Corticosterone	23-37	brain-derived neurotrophic factor	Rattus norvegicus	72-105
16500030-14	2006	We found that although corticosterone and antidepressants both modulate brain-derived neurotrophic factor expression, and antidepressants reverse the corticosterone-induced brain-derived neurotrophic factor decrease, antidepressants and corticosterone differ in how they regulate the expression of brain-derived neurotrophic factor exon(s).	Corticosterone	150-164	brain-derived neurotrophic factor	Rattus norvegicus	72-105
16500030-14	2006	We found that although corticosterone and antidepressants both modulate brain-derived neurotrophic factor expression, and antidepressants reverse the corticosterone-induced brain-derived neurotrophic factor decrease, antidepressants and corticosterone differ in how they regulate the expression of brain-derived neurotrophic factor exon(s).	Corticosterone	150-164	brain-derived neurotrophic factor	Rattus norvegicus	173-206
16500030-14	2006	We found that although corticosterone and antidepressants both modulate brain-derived neurotrophic factor expression, and antidepressants reverse the corticosterone-induced brain-derived neurotrophic factor decrease, antidepressants and corticosterone differ in how they regulate the expression of brain-derived neurotrophic factor exon(s).	Corticosterone	150-164	brain-derived neurotrophic factor	Rattus norvegicus	173-206
16500030-14	2006	We found that although corticosterone and antidepressants both modulate brain-derived neurotrophic factor expression, and antidepressants reverse the corticosterone-induced brain-derived neurotrophic factor decrease, antidepressants and corticosterone differ in how they regulate the expression of brain-derived neurotrophic factor exon(s).	Corticosterone	150-164	brain-derived neurotrophic factor	Rattus norvegicus	72-105
16500030-14	2006	We found that although corticosterone and antidepressants both modulate brain-derived neurotrophic factor expression, and antidepressants reverse the corticosterone-induced brain-derived neurotrophic factor decrease, antidepressants and corticosterone differ in how they regulate the expression of brain-derived neurotrophic factor exon(s).	Corticosterone	150-164	brain-derived neurotrophic factor	Rattus norvegicus	173-206
16500030-14	2006	We found that although corticosterone and antidepressants both modulate brain-derived neurotrophic factor expression, and antidepressants reverse the corticosterone-induced brain-derived neurotrophic factor decrease, antidepressants and corticosterone differ in how they regulate the expression of brain-derived neurotrophic factor exon(s).	Corticosterone	150-164	brain-derived neurotrophic factor	Rattus norvegicus	173-206
16336503-2	2005	in rats, nociceptin/orphanin FQ (N/OFQ) delays gastric emptying and increases plasma corticosterone levels.	Corticosterone	85-99	prepronociceptin	Rattus norvegicus	9-19
16336503-2	2005	in rats, nociceptin/orphanin FQ (N/OFQ) delays gastric emptying and increases plasma corticosterone levels.	Corticosterone	85-99	prepronociceptin	Rattus norvegicus	20-31
16002560-3	2005	To begin the process of identifying pathways by which IUGR affects chromatin structure, we hypothesized that UPI in the rat induces a significant increase in endogenous glucocorticoids (corticosterone) and increases GR expression and activation.	Corticosterone	186-200	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	56-58
16876587-7	2006	In addition, in obesity an increase in interleukin (IL)-1 and IL-6 occurs in mesenteric fat tissue, which together with an increase in corticosterone, is associated with hyperglycemia, dyslipidemias and insulin resistance of obesity-related metabolic syndrome.	Corticosterone	135-149	interleukin 6	Rattus norvegicus	62-66
16339898-9	2005	Further, AMN082 is orally active, penetrates the blood-brain barrier, and elevates the plasma stress hormones corticosterone and corticotropin in an mGluR7-dependent fashion.	Corticosterone	110-124	glutamate receptor, ionotropic, kainate 3	Mus musculus	149-155
16105656-1	2005	11Beta-hydroxylase (CYP11B1) of bovine adrenal cortex produced corticosterone as well as aldosterone from 11-deoxycorticosterone in the presence of the mitochondrial P450 electron transport system.	Corticosterone	63-77	cytochrome P450 11B1, mitochondrial	Bos taurus	20-27
16242669-6	2005	Moreover, cimetidine and corticosterone, OCT2 inhibitors, inhibited the cytotoxicity and the transport of cisplatin in HEK-rOCT2 cells.	Corticosterone	25-39	solute carrier family 22 member 2	Rattus norvegicus	41-45
16242669-6	2005	Moreover, cimetidine and corticosterone, OCT2 inhibitors, inhibited the cytotoxicity and the transport of cisplatin in HEK-rOCT2 cells.	Corticosterone	25-39	solute carrier family 22 member 2	Rattus norvegicus	123-128
16150912-9	2005	c-fos mRNA responses in the anterior pituitary followed those in PVN and reflect central drive of the HPA axis even if corticosterone responses are strongly reduced.	Corticosterone	119-133	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
16179417-1	2005	Aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) catalyze the production of aldosterone and corticosterone, respectively, in the rat adrenal cortex.	Corticosterone	107-121	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	0-20
16179417-1	2005	Aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) catalyze the production of aldosterone and corticosterone, respectively, in the rat adrenal cortex.	Corticosterone	107-121	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	22-29
16179417-1	2005	Aldosterone synthase (CYP11B2) and 11beta-hydroxylase (CYP11B1) catalyze the production of aldosterone and corticosterone, respectively, in the rat adrenal cortex.	Corticosterone	107-121	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	55-62
16285009-3	2005	In this study, we demonstrate that LT induces in mice a rapid increase in the levels of circulating corticosterone, resulting in a dramatic induction of cell death of immature CD4+CD8+, B220+IgM- and IgM+IgD- T and B cell progenitors, respectively.	Corticosterone	100-114	CD4 antigen	Mus musculus	176-179
16320160-2	2005	Alpha-MSH stimulates corticosterone release from rat and human adrenal cells.	Corticosterone	21-35	proopiomelanocortin	Rattus norvegicus	0-9
16320160-5	2005	AgRP antagonises alpha-MSH-induced corticosterone release from rat and bovine adrenal cells.	Corticosterone	35-49	agouti related neuropeptide	Rattus norvegicus	0-4
16320160-5	2005	AgRP antagonises alpha-MSH-induced corticosterone release from rat and bovine adrenal cells.	Corticosterone	35-49	proopiomelanocortin	Rattus norvegicus	17-26
16342524-11	2005	CONCLUSIONS AND CLINICAL RELEVANCE: Serum concentrations of 17OHP or corticosterone after administration of ACTH may be high in dogs with nonadrenal neoplasia and no evidence of hyperadrenocorticism.	Corticosterone	69-83	proopiomelanocortin	Canis lupus familiaris	108-112
16342524-12	2005	Changes in serum 17OHP or corticosterone concentrations after administration of ACTH are proportionate with changes in cortisol concentration.	Corticosterone	26-40	proopiomelanocortin	Canis lupus familiaris	80-84
16174719-9	2005	After ACTH injection, PA females exhibited higher circulating levels of DHEA, androstenedione, and corticosterone but comparable levels of 17alpha-hydroxyprogesterone, cortisol, the sulfoconjugate of DHEA, and testosterone compared with controls.	Corticosterone	99-113	proopiomelanocortin	Homo sapiens	6-10
16423714-2	2005	We now show that social isolation decreased the plasma level of adrenocorticotropin (ACTH), moreover, intracerebroventricular administration of corticotropin releasing factor (CRF) induced a marked increase in the plasma corticosterone level in both isolated and group-housed rats, but this effect was significantly greater in the isolated rats (+121%) than in the group-housed rats (+86%).	Corticosterone	221-235	corticotropin releasing hormone	Rattus norvegicus	144-174
16453979-9	2006	CONCLUSIONS: These data suggest that glucocorticoid-receptor activation by corticosterone participates in the antidepressant-like adaptive changes in 5-HT1A autoreceptors in sleep-deprived mice.	Corticosterone	75-89	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	150-156
16168966-7	2005	These findings support the hypothesis that absence of OT results in a heightened response of the HPA axis to certain stressors and that OT can attenuate the corticosterone response associated with overnight food or water deprivation in male mice.	Corticosterone	157-171	oxytocin	Mus musculus	136-138
16220190-0	2005	[Blockade of NMDA receptor enhances corticosterone-induced downregulation of brain-derived neurotrophic factor gene expression in the rat hippocampus through cAMP response element binding protein pathway].	Corticosterone	36-50	brain-derived neurotrophic factor	Rattus norvegicus	77-110
16220190-0	2005	[Blockade of NMDA receptor enhances corticosterone-induced downregulation of brain-derived neurotrophic factor gene expression in the rat hippocampus through cAMP response element binding protein pathway].	Corticosterone	36-50	cAMP responsive element binding protein 1	Rattus norvegicus	158-195
16220190-3	2005	Because of the importance of brain-derived neurotrophic factor (BDNF) in the functions of the hippocampal neurons, alteration of the expression of BDNF is thought to be involved in the corticosterone effect on the hippocampus.	Corticosterone	185-199	brain-derived neurotrophic factor	Rattus norvegicus	29-62
16220190-3	2005	Because of the importance of brain-derived neurotrophic factor (BDNF) in the functions of the hippocampal neurons, alteration of the expression of BDNF is thought to be involved in the corticosterone effect on the hippocampus.	Corticosterone	185-199	brain-derived neurotrophic factor	Rattus norvegicus	147-151
16220190-6	2005	Furthermore, we intraperitoneally injected NMDA receptor antagonist MK801 (0.1 mg/kg) 30 min before corticosterone administration to investigate whether and how MK801 affected the regulation of BDNF gene expression by corticosterone.	Corticosterone	218-232	brain-derived neurotrophic factor	Rattus norvegicus	194-198
16220190-8	2005	MK801 promoted the downregulation of BDNF gene expression in the rat hippocampus by corticosterone.	Corticosterone	84-98	brain-derived neurotrophic factor	Rattus norvegicus	37-41
16220190-9	2005	We also found that either applying corticosterone or co-applying corticosterone with MK801 downregulated the phosphoration level of CREB, the latter (corticosterone plus MK801) being more effective (P&lt;0.05).	Corticosterone	35-49	cAMP responsive element binding protein 1	Rattus norvegicus	132-136
16220190-9	2005	We also found that either applying corticosterone or co-applying corticosterone with MK801 downregulated the phosphoration level of CREB, the latter (corticosterone plus MK801) being more effective (P&lt;0.05).	Corticosterone	65-79	cAMP responsive element binding protein 1	Rattus norvegicus	132-136
16220190-9	2005	We also found that either applying corticosterone or co-applying corticosterone with MK801 downregulated the phosphoration level of CREB, the latter (corticosterone plus MK801) being more effective (P&lt;0.05).	Corticosterone	65-79	cAMP responsive element binding protein 1	Rattus norvegicus	132-136
16220190-10	2005	Taken together, our results indicate that corticosterone downregulates BDNF gene expression in the rat hippocampus through CREB pathway and that blockade of NMDA receptor enhances this effect of corticosterone in reducing BDNF expression.	Corticosterone	42-56	brain-derived neurotrophic factor	Rattus norvegicus	71-75
16220190-10	2005	Taken together, our results indicate that corticosterone downregulates BDNF gene expression in the rat hippocampus through CREB pathway and that blockade of NMDA receptor enhances this effect of corticosterone in reducing BDNF expression.	Corticosterone	42-56	cAMP responsive element binding protein 1	Rattus norvegicus	123-127
16079146-6	2005	A predominant role of the GR was further supported by the observation that corticosterone could elevate GLT-1 expression in a dose-dependent manner, whereas aldosterone, the physiological ligand of the mineralocorticoid receptor, exerted only weak effects even when applied at high concentrations.	Corticosterone	75-89	solute carrier family 1 member 2	Rattus norvegicus	104-109
16168966-0	2005	Corticosterone release is heightened in food or water deprived oxytocin deficient male mice.	Corticosterone	0-14	oxytocin	Mus musculus	63-71
16168966-2	2005	OT deficient (OT-/-) female mice had higher plasma corticosterone concentrations than wild type (OT+/+) female mice following exposure to platform shaker (Mantella et al., 2004).	Corticosterone	51-65	oxytocin	Mus musculus	0-2
16168966-2	2005	OT deficient (OT-/-) female mice had higher plasma corticosterone concentrations than wild type (OT+/+) female mice following exposure to platform shaker (Mantella et al., 2004).	Corticosterone	51-65	oxytocin	Mus musculus	14-16
16168966-2	2005	OT deficient (OT-/-) female mice had higher plasma corticosterone concentrations than wild type (OT+/+) female mice following exposure to platform shaker (Mantella et al., 2004).	Corticosterone	51-65	oxytocin	Mus musculus	14-16
16168966-3	2005	The present study examined the corticosterone response of OT-/- and OT+/+ male mice that were exposed to shaker stress or other stressors (i.e., administration of cholecystokinin (CCK), dehydration, or fasting) that are known to activate central OT neurons in mice.	Corticosterone	31-45	oxytocin	Mus musculus	58-60
16168966-5	2005	Plasma corticosterone concentrations were higher in OT-/- than OT+/+ male mice that were water deprived (P &lt; 0.05) or fasted (P &lt; 0.03), whereas corticosterone concentrations following exposure to platform shaker or CCK administration (10 microg/kg i.p.)	Corticosterone	7-21	oxytocin	Mus musculus	52-54
16237048-4	2005	MIF-/- mice displayed markedly elevated corticosterone levels and significant decreases in the inflammatory cytokines TNF-alpha, IFN-gamma, IL-2, and IL-6 before, during, and after EAE onset.	Corticosterone	40-54	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	0-3
16033944-0	2005	Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells.	Corticosterone	0-14	carbonic anhydrase 1	Mus musculus	91-94
16033944-2	2005	We here tested the effect of a high dose of corticosterone on AMPA-receptor-mediated transmission in the CA1 hippocampal area, which is enriched in corticosteroid receptors.	Corticosterone	44-58	carbonic anhydrase 1	Mus musculus	105-108
16268952-0	2005	Enhanced non-esterified fatty acids and corticosterone in blood plasma of chickens treated with insulin are significantly depleted by reverse T: minor changes in hypoglycaemia.	Corticosterone	40-54	insulin	Gallus gallus	96-103
16268952-10	2005	Insulin treatment peaked the corticosterone levels maximally by 507.6% above control.	Corticosterone	29-43	insulin	Gallus gallus	0-7
16220190-10	2005	Taken together, our results indicate that corticosterone downregulates BDNF gene expression in the rat hippocampus through CREB pathway and that blockade of NMDA receptor enhances this effect of corticosterone in reducing BDNF expression.	Corticosterone	42-56	brain-derived neurotrophic factor	Rattus norvegicus	222-226
16220190-10	2005	Taken together, our results indicate that corticosterone downregulates BDNF gene expression in the rat hippocampus through CREB pathway and that blockade of NMDA receptor enhances this effect of corticosterone in reducing BDNF expression.	Corticosterone	195-209	brain-derived neurotrophic factor	Rattus norvegicus	71-75
16220190-10	2005	Taken together, our results indicate that corticosterone downregulates BDNF gene expression in the rat hippocampus through CREB pathway and that blockade of NMDA receptor enhances this effect of corticosterone in reducing BDNF expression.	Corticosterone	195-209	cAMP responsive element binding protein 1	Rattus norvegicus	123-127
16220190-10	2005	Taken together, our results indicate that corticosterone downregulates BDNF gene expression in the rat hippocampus through CREB pathway and that blockade of NMDA receptor enhances this effect of corticosterone in reducing BDNF expression.	Corticosterone	195-209	brain-derived neurotrophic factor	Rattus norvegicus	222-226
16132951-16	2005	In contrast, PVN DN-AMPK overexpression attenuated late counter-regulation and corticosterone responses.	Corticosterone	79-93	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	20-24
15994342-10	2005	Leptin suppression of insulin and corticosterone in Lep(ob)/Lep(ob) mice were not significantly affected by Mc4r genotype.	Corticosterone	34-48	leptin	Mus musculus	0-6
15994342-10	2005	Leptin suppression of insulin and corticosterone in Lep(ob)/Lep(ob) mice were not significantly affected by Mc4r genotype.	Corticosterone	34-48	leptin	Mus musculus	0-3
15994342-10	2005	Leptin suppression of insulin and corticosterone in Lep(ob)/Lep(ob) mice were not significantly affected by Mc4r genotype.	Corticosterone	34-48	leptin	Mus musculus	52-55
16236352-5	2005	Following swim, serum corticosterone (CORT) levels were significantly elevated in both escape and yoked groups in comparison to confined and home cage controls.	Corticosterone	22-36	cortistatin	Rattus norvegicus	38-42
16098684-3	2005	We found that CD-1 mice had significantly higher corticosterone levels compared to BKW mice both before and after pairing.	Corticosterone	49-63	CD1 antigen complex	Mus musculus	14-18
16098684-6	2005	Social status was nevertheless found to be associated with pre-existing differences in urinary corticosterone in the CD-1 strain: mice that later became dominant had overall lower levels of urinary corticosterone compared to subordinates.	Corticosterone	95-109	CD1 antigen complex	Mus musculus	117-121
16098684-6	2005	Social status was nevertheless found to be associated with pre-existing differences in urinary corticosterone in the CD-1 strain: mice that later became dominant had overall lower levels of urinary corticosterone compared to subordinates.	Corticosterone	198-212	CD1 antigen complex	Mus musculus	117-121
16112151-5	2005	Lactation has been associated with a down-regulation of the hypothalamic-pituitary-adrenal (HPA) axis and, accordingly, a decrease in plasma corticosterone (CORT) in several species, including humans.	Corticosterone	141-155	cortistatin	Homo sapiens	157-161
15941601-7	2005	Ts65Dn and control mice subjected to enriched housing in large groups and Ts65Dn mice housed in large groups showed higher corticosterone levels.	Corticosterone	123-137	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	74-80
15961565-5	2005	In this study, we found that the Erk1/2, c-Jun N-terminal kinase (JNK), and p38 MAPKs were activated in these neurons by BSA-conjugated corticosterone within 15 min of treatment.	Corticosterone	136-150	mitogen-activated protein kinase 3	Homo sapiens	33-39
15961565-5	2005	In this study, we found that the Erk1/2, c-Jun N-terminal kinase (JNK), and p38 MAPKs were activated in these neurons by BSA-conjugated corticosterone within 15 min of treatment.	Corticosterone	136-150	mitogen-activated protein kinase 8	Homo sapiens	41-64
15961565-5	2005	In this study, we found that the Erk1/2, c-Jun N-terminal kinase (JNK), and p38 MAPKs were activated in these neurons by BSA-conjugated corticosterone within 15 min of treatment.	Corticosterone	136-150	mitogen-activated protein kinase 8	Homo sapiens	66-69
15961565-5	2005	In this study, we found that the Erk1/2, c-Jun N-terminal kinase (JNK), and p38 MAPKs were activated in these neurons by BSA-conjugated corticosterone within 15 min of treatment.	Corticosterone	136-150	mitogen-activated protein kinase 1	Homo sapiens	76-79
15972802-6	2005	When this increased corticosterone response was negated by adrenalectomy or by administration of the glucocorticoid receptor antagonist RU-486, both the cytokine and febrile responses were normalized.	Corticosterone	20-34	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	101-124
16131595-0	2005	Regulation of CRH-induced secretion of ACTH and corticosterone by SOM230 in rats.	Corticosterone	48-62	corticotropin releasing hormone	Rattus norvegicus	14-17
16131595-3	2005	The present study aimed to determine the inhibitory effect of the multireceptor ligand SOM230, compared with the sst2-preferring agonist octreotide, on corticotropin-releasing hormone (CRH)-stimulated secretion of ACTH and corticosterone in rats.	Corticosterone	223-237	corticotropin releasing hormone	Rattus norvegicus	185-188
16204770-6	2005	L-NAME (2 mg/kg), a general nitric oxide synthase (NOS) inhibitor, considerably reduced the ACTH and corticosterone response to IL-1beta (0.5 microg/rat) the same extent in control and crowded rats.	Corticosterone	101-115	interleukin 1 beta	Rattus norvegicus	128-136
15919584-4	2005	One week of CORT administration (100mg-21 day release pellet) in ADX rats produced statistically significant decreases in MAO-A enzyme activity and MAO-B gene expression in the liver but no significant changes for any of the three enzymes in either activity or gene expression in the medial prefrontal cortex or striatum.	Corticosterone	12-16	monoamine oxidase A	Rattus norvegicus	122-127
15961555-2	2005	Adrenalectomy (ADX) reduced orexin-A-induced feeding over 4 h by about 60%, compared with shams, an effect that was reversed by corticosterone (CORT) replacement.	Corticosterone	128-142	hypocretin neuropeptide precursor	Rattus norvegicus	28-36
15961555-2	2005	Adrenalectomy (ADX) reduced orexin-A-induced feeding over 4 h by about 60%, compared with shams, an effect that was reversed by corticosterone (CORT) replacement.	Corticosterone	128-142	cortistatin	Rattus norvegicus	144-148
16206569-3	2005	The results suggest that PTHrP may act directly on the adrenocortical cells via its receptor binding and increase the response to ACTH for corticosterone secretion in the hen.	Corticosterone	139-153	parathyroid hormone like hormone	Gallus gallus	25-30
15919584-4	2005	One week of CORT administration (100mg-21 day release pellet) in ADX rats produced statistically significant decreases in MAO-A enzyme activity and MAO-B gene expression in the liver but no significant changes for any of the three enzymes in either activity or gene expression in the medial prefrontal cortex or striatum.	Corticosterone	12-16	monoamine oxidase B	Rattus norvegicus	148-153
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	mitogen-activated protein kinase kinase 7	Homo sapiens	71-110
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	mitogen-activated protein kinase kinase 7	Homo sapiens	112-115
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	TXK tyrosine kinase	Homo sapiens	136-151
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	TXK tyrosine kinase	Homo sapiens	153-155
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	Janus kinase 2	Homo sapiens	180-203
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	Janus kinase 2	Homo sapiens	205-209
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	mitogen-activated protein kinase 1	Homo sapiens	244-281
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	mitogen-activated protein kinase 1	Homo sapiens	283-286
16061232-2	2005	Magnolol-induced corticosterone production was completely inhibited by mitogen-activated protein kinase kinase (MEK)-inhibitor PD98059, tyrosine kinase (TK)-inhibitor genistein or Janus tyrosine kinase 2 (JAK2)-inhibitor AG490, suggesting that extracellular signal-regulated kinase (ERK) and JAK2 are both involved in this signaling cascade.	Corticosterone	17-31	Janus kinase 2	Homo sapiens	292-296
16012765-3	2005	Handling and sc injection per se elicited a moderate increase in the plasma concentrations of ACTH and corticosterone, which was counteracted by beacon.	Corticosterone	103-117	ubiquitin-like 5	Rattus norvegicus	145-151
16046291-2	2005	The responses of Pomc-/- and wild-type mice to the administration of corticosterone were compared.	Corticosterone	69-83	pro-opiomelanocortin-alpha	Mus musculus	17-21
16046291-3	2005	In study 1, mice were given corticosterone-supplemented water (CORT) for 10 days, resulting in plasma CORT levels within the physiological range, with partial suppression of hypothalamic corticotropin-releasing hormone expression to a similar degree between genotypes.	Corticosterone	28-42	cortistatin	Mus musculus	63-67
16046291-3	2005	In study 1, mice were given corticosterone-supplemented water (CORT) for 10 days, resulting in plasma CORT levels within the physiological range, with partial suppression of hypothalamic corticotropin-releasing hormone expression to a similar degree between genotypes.	Corticosterone	28-42	cortistatin	Mus musculus	102-106
16046291-3	2005	In study 1, mice were given corticosterone-supplemented water (CORT) for 10 days, resulting in plasma CORT levels within the physiological range, with partial suppression of hypothalamic corticotropin-releasing hormone expression to a similar degree between genotypes.	Corticosterone	28-42	corticotropin releasing hormone	Mus musculus	187-218
16012765-4	2005	Similarly, beacon dampened ACTH and corticosterone responses to ether stress.	Corticosterone	36-50	ubiquitin-like 5	Rattus norvegicus	11-17
16012765-5	2005	In contrast, beacon did not affect ACTH response to cold stress, although it was able to induce a moderate lowering in the corticosterone response.	Corticosterone	123-137	ubiquitin-like 5	Rattus norvegicus	13-19
16012765-6	2005	Taken together, these findings allow us to draw the following conclusions: i) beacon inhibits handling/injection- and ether stress-activated, but not cold stress-activated, neural mechanism(s) responsible for stimulation of ACTH secretion and the ensuing increase in corticosterone production; and ii) the beacon-induced dampening in corticosterone response to stress also involves a direct inhibitory effect on the adrenal-cortex secretory activity.	Corticosterone	267-281	ubiquitin-like 5	Rattus norvegicus	78-84
16012765-6	2005	Taken together, these findings allow us to draw the following conclusions: i) beacon inhibits handling/injection- and ether stress-activated, but not cold stress-activated, neural mechanism(s) responsible for stimulation of ACTH secretion and the ensuing increase in corticosterone production; and ii) the beacon-induced dampening in corticosterone response to stress also involves a direct inhibitory effect on the adrenal-cortex secretory activity.	Corticosterone	267-281	ubiquitin-like 5	Rattus norvegicus	306-312
16012765-6	2005	Taken together, these findings allow us to draw the following conclusions: i) beacon inhibits handling/injection- and ether stress-activated, but not cold stress-activated, neural mechanism(s) responsible for stimulation of ACTH secretion and the ensuing increase in corticosterone production; and ii) the beacon-induced dampening in corticosterone response to stress also involves a direct inhibitory effect on the adrenal-cortex secretory activity.	Corticosterone	334-348	ubiquitin-like 5	Rattus norvegicus	78-84
16012765-6	2005	Taken together, these findings allow us to draw the following conclusions: i) beacon inhibits handling/injection- and ether stress-activated, but not cold stress-activated, neural mechanism(s) responsible for stimulation of ACTH secretion and the ensuing increase in corticosterone production; and ii) the beacon-induced dampening in corticosterone response to stress also involves a direct inhibitory effect on the adrenal-cortex secretory activity.	Corticosterone	334-348	ubiquitin-like 5	Rattus norvegicus	306-312
15882914-6	2005	Simultaneously, plasma corticosterone concentrations were elevated in PACAP-injected animals, and significant increases were observed in face washing, body grooming, rearing and wet-dog shakes behaviors.	Corticosterone	23-37	adenylate cyclase activating polypeptide 1	Homo sapiens	70-75
15996692-6	2005	Subdiaphragmatic vagotomy also attenuated the IL-1beta- and LPS-induced increases in plasma ACTH and corticosterone, but the attenuations of the responses to IL-1beta were only marginally significant.	Corticosterone	101-115	interleukin 1 beta	Mus musculus	46-54
15996692-6	2005	Subdiaphragmatic vagotomy also attenuated the IL-1beta- and LPS-induced increases in plasma ACTH and corticosterone, but the attenuations of the responses to IL-1beta were only marginally significant.	Corticosterone	101-115	toll-like receptor 4	Mus musculus	60-63
15972209-8	2005	We acutely administered ascending doses of corticosterone and found an increase in CART message.	Corticosterone	43-57	CART prepropeptide	Rattus norvegicus	83-87
15972209-10	2005	This suggests that CART mRNA may be regulated by cocaine under certain conditions, such as binge administration, and this may at least partly involve corticosterone.	Corticosterone	150-164	CART prepropeptide	Rattus norvegicus	19-23
15718389-0	2005	Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury.	Corticosterone	0-14	mitogen activated protein kinase 14	Rattus norvegicus	70-73
15718389-0	2005	Corticosterone suppresses mesenteric lymph node T cells by inhibiting p38/ERK pathway and promotes bacterial translocation after alcohol and burn injury.	Corticosterone	0-14	Eph receptor B1	Rattus norvegicus	74-77
15586384-1	2005	BACKGROUND: In rodents, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inactive 11-dehydrocorticosterone (DHC) into active corticosterone.	Corticosterone	120-134	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	35-77
15586384-1	2005	BACKGROUND: In rodents, the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inactive 11-dehydrocorticosterone (DHC) into active corticosterone.	Corticosterone	120-134	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	79-90
15994759-8	2005	RESULTS: Basal plasma corticosterone and corticosterone binding globulin (CBG) concentrations were significantly increased in short- and long-term hyperthyroid rats, and by 60 days, cerebrospinal fluid (CSF) corticosterone levels were significantly increased.	Corticosterone	41-55	serpin family A member 6	Rattus norvegicus	74-77
15942675-7	2005	The beacon-induced lowering in the secretory activity of adrenal cortex depended on similar reductions (from 50-64%) in the production of the main adrenocortical hormones (pregnenolone, progesterone, 11-deoxycorticosterone, corticosterone, 18-hydroxy-corticosterone and aldosterone), thereby suggesting an inhibitory action of beacon in the early step of steroidogenesis (i.e. the conversion of cholesterol to pregnenolone).	Corticosterone	208-222	ubiquitin-like 5	Rattus norvegicus	4-10
15953348-11	2005	Hippocampal free corticosterone levels were elevated by CRF, urocortin 1 and 3, but not by urocortin 2.	Corticosterone	17-31	urocortin 3	Rattus norvegicus	61-78
15911129-4	2005	The effect of corticosterone on the expression of 11beta-HSD1 was studied in cultured hippocampal neurons derived from newborn offspring received prenatal dexamethasone treatments.	Corticosterone	14-28	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	50-61
15911129-7	2005	Corticosterone could induce 11beta-HSD1 expression in cultured hippocampal neurons prepared from newborns received prenatal dexamethasone treatments, which was blocked by glucocorticoid receptor antagonist RU38486.	Corticosterone	0-14	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	28-39
15911129-7	2005	Corticosterone could induce 11beta-HSD1 expression in cultured hippocampal neurons prepared from newborns received prenatal dexamethasone treatments, which was blocked by glucocorticoid receptor antagonist RU38486.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	171-194
15723229-1	2005	RATIONALE: Following repeated injections with nicotine paired with a distinctive environment, some studies have reported that the distinctive context becomes a conditioned stimulus (CS) capable of eliciting conditioned corticosterone (CORT) release.	Corticosterone	219-233	cortistatin	Rattus norvegicus	235-239
15942146-10	2005	Furthermore, corticosterone suppressed the IFN-gamma production by cultured IEL, which was prevented by Mifepristone (RU486), a GR antagonist.	Corticosterone	13-27	interferon gamma	Mus musculus	43-52
15942146-11	2005	In summary, repeated foot shock stress did not alter the numbers of IEL and CD3+ IEL subsets, but suppressed IFN-gamma production by IEL, which was probably mediated by the elevated corticosterone.	Corticosterone	182-196	interferon gamma	Mus musculus	109-118
15919058-10	2005	These results indicate that PVN CRF1 receptor mRNA is much more sensitive to glucocorticoid-mediated negative feedback in mice than in rats, such that a normal increase in plasma corticosterone during stress can mask CRF1 receptor mRNA induction in the PVN of mice.	Corticosterone	179-193	corticotropin releasing hormone receptor 1	Mus musculus	32-45
15919058-10	2005	These results indicate that PVN CRF1 receptor mRNA is much more sensitive to glucocorticoid-mediated negative feedback in mice than in rats, such that a normal increase in plasma corticosterone during stress can mask CRF1 receptor mRNA induction in the PVN of mice.	Corticosterone	179-193	corticotropin releasing hormone receptor 1	Mus musculus	217-230
15925328-4	2005	The plasma corticosterone level, which was markedly increased by food deprivation, decreased significantly within 30 min after refeeding and returned to the free fed control level by 6 h. Synthetic glucocorticoid dexamethasone blocked the refeeding-induced nNOS expression in the PVN without suppressing food intake.	Corticosterone	11-25	nitric oxide synthase 1	Rattus norvegicus	257-261
15939085-7	2005	Central TRH stimulated both corticosterone and epinephrine release.	Corticosterone	28-42	thyrotropin releasing hormone	Homo sapiens	8-11
15939085-9	2005	injection of a corticotropin-releasing factor receptor antagonist attenuated the change in body temperature and corticosterone concentration caused by TRH, but did not influence plasma T3 and T4 concentrations.	Corticosterone	112-126	thyrotropin releasing hormone	Homo sapiens	151-154
15904708-1	2005	Corticosterone (CORT) micropellets were stereotaxically placed bilaterally at the dorsal margin of the central nucleus of the amygdala (CeA).	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
15904708-1	2005	Corticosterone (CORT) micropellets were stereotaxically placed bilaterally at the dorsal margin of the central nucleus of the amygdala (CeA).	Corticosterone	0-14	CEA cell adhesion molecule 3	Homo sapiens	136-139
15671079-0	2005	Disruption of mineralocorticoid receptor function increases corticosterone responding to a mild, but not moderate, psychological stressor.	Corticosterone	60-74	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	14-40
15671079-5	2005	Recent work in our laboratory suggests that previous estimates of MR occupancy at resting plasma levels of corticosterone (CORT) may be overestimated.	Corticosterone	107-121	cortistatin	Rattus norvegicus	123-127
15731356-8	2005	Transplantation of POMC-null mutant adrenals to adrenalectomized wild-type littermates results in adrenals with normal morphology and production of both corticosterone and aldosterone.	Corticosterone	153-167	pro-opiomelanocortin-alpha	Mus musculus	19-23
15731365-4	2005	Adult AS-null mice are small, weigh 75% of wild type, are hypotensive, have increased concentrations of plasma K(+) and corticosterone, and a decreased concentration of plasma Cl(-).	Corticosterone	120-134	cytochrome P450, family 11, subfamily b, polypeptide 2	Mus musculus	6-8
15746256-0	2005	Inverse shift in circulating corticosterone and leptin levels elevates hypothalamic deiodinase type 2 in fasted rats.	Corticosterone	29-43	solute carrier family 3 member 1	Rattus norvegicus	84-101
15746256-7	2005	In food-deprived animals, corticosterone replacement reversed the inhibitory effect of adrenalectomy (ADX) on D2 induction, whereas ADX and ADX plus corticosterone replacement did not significantly affect D2 activity levels in rats fed ad libitum.	Corticosterone	26-40	solute carrier family 3 member 1	Rattus norvegicus	110-112
15746256-8	2005	Leptin administration to fed animals did not change D2 activity, whereas in fasted rats, leptin decreased D2 activity by reducing corticosterone plasma levels.	Corticosterone	130-144	leptin	Rattus norvegicus	89-95
15746256-8	2005	Leptin administration to fed animals did not change D2 activity, whereas in fasted rats, leptin decreased D2 activity by reducing corticosterone plasma levels.	Corticosterone	130-144	solute carrier family 3 member 1	Rattus norvegicus	106-108
15746256-9	2005	When leptin was administered to fasted animals that were either ADX or ADX plus corticosterone treated at a high dose, D2 activity did not increase.	Corticosterone	80-94	leptin	Rattus norvegicus	5-11
15761036-1	2005	Corticosterone (CORT) suppresses Leydig cell steroidogenesis by inhibiting the expression of proteins involved in testosterone biosynthesis including steroidogenic acute regulatory protein and steroidogenic enzymes.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
16077171-2	2005	Centrally administered NPW caused a dose-dependent increase in corticosterone levels in rats.	Corticosterone	63-77	neuropeptide W	Rattus norvegicus	23-26
15930164-2	2005	In vivo, a significant negative feedback was detected on the levels of corticotropin-releasing factor (CRF) precursor (proCRF) mRNA and on the plasma concentration of corticosterone, two hours after a single intravenous injection with 40 microg corticosterone.	Corticosterone	245-259	corticotropin releasing hormone	Gallus gallus	71-101
15930379-7	2005	In additional experiments, the elevated corticosterone response to SEA was abrogated in TNF-/- mice and was shown to be corticotropin-releasing hormone dependent.	Corticosterone	40-54	tumor necrosis factor	Mus musculus	88-91
15930379-7	2005	In additional experiments, the elevated corticosterone response to SEA was abrogated in TNF-/- mice and was shown to be corticotropin-releasing hormone dependent.	Corticosterone	40-54	corticotropin releasing hormone	Mus musculus	120-151
15755911-8	2005	Western blot analyses revealed that CT induced an elevation of bcl-xL but not bcl-2 or proapoptotic factors bax, bak, and bad.	Corticosterone	36-38	BCL2 like 1	Homo sapiens	63-69
15755911-9	2005	Inhibiting the expression of bcl-xL reduced the cytoprotective effect of CT. Our data suggest that CT induces a cytoprotective effect on cardiomyocytes in association with reprogramming gene expression and induction of bcl-xL gene.	Corticosterone	73-75	BCL2 like 1	Homo sapiens	29-35
15755911-9	2005	Inhibiting the expression of bcl-xL reduced the cytoprotective effect of CT. Our data suggest that CT induces a cytoprotective effect on cardiomyocytes in association with reprogramming gene expression and induction of bcl-xL gene.	Corticosterone	73-75	BCL2 like 1	Homo sapiens	219-225
15846779-1	2005	Rapid activation of JNK and p38 and their translocation to the cell nucleus by glucocorticoids, corticosterone (Cort), and bovine serum-conjugated corticosterone (Cort-BSA) were studied in primary cultured hippocampal cells by using immunoblotting and immunofluorescence confocal microscopy.	Corticosterone	96-110	mitogen-activated protein kinase 14	Homo sapiens	28-31
15905218-2	2005	Central administration of CGRP activates the hypothalamo-pituitary-adrenal axis resulting in increased corticosterone secretion.	Corticosterone	103-117	calcitonin-related polypeptide alpha	Rattus norvegicus	26-30
16157481-6	2005	Orexin-A, but not orexin-B, concentration-dependently increased corticosterone and cortisol secretion from cultured rat and human adrenocortical cells, respectively.	Corticosterone	64-78	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
15846779-1	2005	Rapid activation of JNK and p38 and their translocation to the cell nucleus by glucocorticoids, corticosterone (Cort), and bovine serum-conjugated corticosterone (Cort-BSA) were studied in primary cultured hippocampal cells by using immunoblotting and immunofluorescence confocal microscopy.	Corticosterone	112-116	mitogen-activated protein kinase 14	Homo sapiens	28-31
15846779-1	2005	Rapid activation of JNK and p38 and their translocation to the cell nucleus by glucocorticoids, corticosterone (Cort), and bovine serum-conjugated corticosterone (Cort-BSA) were studied in primary cultured hippocampal cells by using immunoblotting and immunofluorescence confocal microscopy.	Corticosterone	147-161	mitogen-activated protein kinase 14	Homo sapiens	28-31
15598670-2	2005	The objective of this study was to measure the effects of thermal injury on mice on corticosterone (Cort) levels in relation with corticosteroid-binding globulin (CBG) and thymus cell populations.	Corticosterone	84-98	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	130-161
15854660-3	2005	As a test case, this strategy was used to engineer variants of human estrogen receptor alpha ligand-binding domain (hERalphaLBD) with novel corticosterone activity.	Corticosterone	140-154	estrogen receptor 1	Homo sapiens	69-92
15598670-2	2005	The objective of this study was to measure the effects of thermal injury on mice on corticosterone (Cort) levels in relation with corticosteroid-binding globulin (CBG) and thymus cell populations.	Corticosterone	84-98	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	163-166
15598670-2	2005	The objective of this study was to measure the effects of thermal injury on mice on corticosterone (Cort) levels in relation with corticosteroid-binding globulin (CBG) and thymus cell populations.	Corticosterone	100-104	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	130-161
15598670-2	2005	The objective of this study was to measure the effects of thermal injury on mice on corticosterone (Cort) levels in relation with corticosteroid-binding globulin (CBG) and thymus cell populations.	Corticosterone	100-104	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	163-166
15806308-3	2005	We previously found that rat adrenocortical cells express both orexin-receptor subtypes, and orexin-A stimulates corticosterone secretion from dispersed adrenocortical cells acting via the OX1-R.	Corticosterone	113-127	hypocretin neuropeptide precursor	Rattus norvegicus	93-101
15806308-3	2005	We previously found that rat adrenocortical cells express both orexin-receptor subtypes, and orexin-A stimulates corticosterone secretion from dispersed adrenocortical cells acting via the OX1-R.	Corticosterone	113-127	hypocretin receptor 1	Rattus norvegicus	189-194
15662045-0	2005	Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region.	Corticosterone	30-44	solute carrier family 22 member 1	Rattus norvegicus	80-85
15829718-5	2005	Plasma corticosterone levels peaked at 3.3-fold baseline levels after 30-h sustained hyperthermia and returned to baseline by 42 h. Immunoneutralization of G-CSF blocked FRH-induced peripheral neutrophilia, but blockade of the glucocorticoid receptor with mifepristone failed to modify FRH-induced neutrophilia.	Corticosterone	7-21	colony stimulating factor 3 (granulocyte)	Mus musculus	156-161
15843539-6	2005	This effect of CRH is independent of its ability to increase corticosterone production, because adrenalectomized wild-type mice had similar disease course and severity as control mice.	Corticosterone	61-75	corticotropin releasing hormone	Mus musculus	15-18
15662045-0	2005	Subtype-specific affinity for corticosterone of rat organic cation transporters rOCT1 and rOCT2 depends on three amino acids within the substrate binding region.	Corticosterone	30-44	solute carrier family 22 member 2	Rattus norvegicus	90-95
15662045-2	2005	For example, the IC50 values for corticosterone inhibition of cation uptake by transporters rOCT1 and rOCT2 are approximately 150 and approximately 4 microM, respectively.	Corticosterone	33-47	solute carrier family 22 member 1	Rattus norvegicus	92-97
15662045-2	2005	For example, the IC50 values for corticosterone inhibition of cation uptake by transporters rOCT1 and rOCT2 are approximately 150 and approximately 4 microM, respectively.	Corticosterone	33-47	solute carrier family 22 member 2	Rattus norvegicus	102-107
15662045-3	2005	By introducing domains and amino acids from rOCT2 into rOCT1, we found that the exchange of three amino acids in the presumed 10th transmembrane alpha helix is sufficient to increase the affinity of rOCT1 for corticosterone to that of rOCT2.	Corticosterone	209-223	solute carrier family 22 member 2	Rattus norvegicus	44-49
15662045-3	2005	By introducing domains and amino acids from rOCT2 into rOCT1, we found that the exchange of three amino acids in the presumed 10th transmembrane alpha helix is sufficient to increase the affinity of rOCT1 for corticosterone to that of rOCT2.	Corticosterone	209-223	solute carrier family 22 member 1	Rattus norvegicus	55-60
15662045-3	2005	By introducing domains and amino acids from rOCT2 into rOCT1, we found that the exchange of three amino acids in the presumed 10th transmembrane alpha helix is sufficient to increase the affinity of rOCT1 for corticosterone to that of rOCT2.	Corticosterone	209-223	solute carrier family 22 member 1	Rattus norvegicus	199-204
15662045-3	2005	By introducing domains and amino acids from rOCT2 into rOCT1, we found that the exchange of three amino acids in the presumed 10th transmembrane alpha helix is sufficient to increase the affinity of rOCT1 for corticosterone to that of rOCT2.	Corticosterone	209-223	solute carrier family 22 member 2	Rattus norvegicus	235-240
15662045-4	2005	Replacement of these amino acids in rOCT2 decreased the affinity for corticosterone.	Corticosterone	69-83	solute carrier family 22 member 2	Rattus norvegicus	36-41
15662045-5	2005	These amino acids (Ala443, Leu447, and Gln448 in rOCT1 and Ile443, Tyr447, and Glu448 in rOCT2) are probably located within the substrate binding region because in rOCT1 mutants, the K(m) values for uptake of tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP) were decreased in parallel with a decrease of the IC50 values for the inhibition of cation uptake by corticosterone.	Corticosterone	373-387	solute carrier family 22 member 1	Rattus norvegicus	49-54
15833364-0	2005	CRH stimulates POMC activity and corticosterone production in dermal fibroblasts.	Corticosterone	33-47	corticotropin releasing hormone	Homo sapiens	0-3
15662045-5	2005	These amino acids (Ala443, Leu447, and Gln448 in rOCT1 and Ile443, Tyr447, and Glu448 in rOCT2) are probably located within the substrate binding region because in rOCT1 mutants, the K(m) values for uptake of tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP) were decreased in parallel with a decrease of the IC50 values for the inhibition of cation uptake by corticosterone.	Corticosterone	373-387	solute carrier family 22 member 2	Rattus norvegicus	89-94
15662045-5	2005	These amino acids (Ala443, Leu447, and Gln448 in rOCT1 and Ile443, Tyr447, and Glu448 in rOCT2) are probably located within the substrate binding region because in rOCT1 mutants, the K(m) values for uptake of tetraethylammonium (TEA) and 1-methyl-4-phenylpyridinium (MPP) were decreased in parallel with a decrease of the IC50 values for the inhibition of cation uptake by corticosterone.	Corticosterone	373-387	solute carrier family 22 member 1	Rattus norvegicus	164-169
15833364-4	2005	Furthermore, CRH and ACTH stimulate production of corticosterone in fibroblasts, with ACTH being more potent.	Corticosterone	50-64	corticotropin releasing hormone	Homo sapiens	13-16
15662045-6	2005	In mutant rOCT1(L447Y/Q448E), the IC50 value for the inhibition of [3H]MPP (0.1 microM) uptake by corticosterone (24 +/- 4 microM) was significantly higher compared with the IC50 value for inhibition of [14C]TEA (10 microM) uptake (5.3 +/- 1.7 microM).	Corticosterone	98-112	solute carrier family 22 member 1	Rattus norvegicus	10-15
15833364-4	2005	Furthermore, CRH and ACTH stimulate production of corticosterone in fibroblasts, with ACTH being more potent.	Corticosterone	50-64	proopiomelanocortin	Homo sapiens	21-25
15857670-8	2005	glucose relative to saline was lost and actually reversed into a 50% increase in NPY and AgRP, possibly attributed to a decline in circulating glucose followed by a 50% rise in corticosterone at 60 min.	Corticosterone	177-191	neuropeptide Y	Rattus norvegicus	81-84
15833364-8	2005	However, it diverges from the HPA organization in its distal step, where CRH and ACTH stimulate production of corticosterone, instead of cortisol.	Corticosterone	110-124	corticotropin releasing hormone	Homo sapiens	73-76
15833364-8	2005	However, it diverges from the HPA organization in its distal step, where CRH and ACTH stimulate production of corticosterone, instead of cortisol.	Corticosterone	110-124	proopiomelanocortin	Homo sapiens	81-85
15857670-8	2005	glucose relative to saline was lost and actually reversed into a 50% increase in NPY and AgRP, possibly attributed to a decline in circulating glucose followed by a 50% rise in corticosterone at 60 min.	Corticosterone	177-191	agouti related neuropeptide	Rattus norvegicus	89-93
15837925-0	2005	The rapid release of corticosterone from the adrenal induced by ACTH is mediated by nitric oxide acting by prostaglandin E2.	Corticosterone	21-35	proopiomelanocortin	Homo sapiens	64-68
15837925-4	2005	We demonstrated that both sodium nitroprusside (NP), a nitric oxide (NO) donor, and ACTH stimulate corticosterone release.	Corticosterone	99-113	proopiomelanocortin	Homo sapiens	84-88
15837925-5	2005	NO mediated the acute response to ACTH because Nomega-nitro-l-arginine methyl ester, a NO synthase inhibitor, and hemoglobin, a NO scavenger, blocked the stimulation of corticosterone release induced by ACTH.	Corticosterone	169-183	proopiomelanocortin	Homo sapiens	34-38
15837925-5	2005	NO mediated the acute response to ACTH because Nomega-nitro-l-arginine methyl ester, a NO synthase inhibitor, and hemoglobin, a NO scavenger, blocked the stimulation of corticosterone release induced by ACTH.	Corticosterone	169-183	proopiomelanocortin	Homo sapiens	203-207
15837925-7	2005	Additionally, indomethacin, which inhibits cyclooxygenase, and thereby, prostaglandin release, prevented corticosterone release from the adrenal induced by both NP and ACTH, demonstrating that prostaglandins mediate acute corticosterone release.	Corticosterone	105-119	proopiomelanocortin	Homo sapiens	168-172
15837925-8	2005	Corticosterone content in adrenals after incubation with ACTH or NP was lower than in control glands, indicating that any de novo synthesis of corticosterone during this period was not sufficient to keep up with the release of the stored hormone.	Corticosterone	0-14	proopiomelanocortin	Homo sapiens	57-61
15837925-9	2005	The release induced by ACTH or NP depleted the corticosterone content in the adrenal by approximately 40% compared with the content of glands incubated in buffer.	Corticosterone	47-61	proopiomelanocortin	Homo sapiens	23-27
15837925-10	2005	The mechanism of rapid release is as follows: NO produced by NO synthase activation by ACTH activates cyclooxygenase, which generates PGE(2), which in turn releases corticosterone stored in microvesicles and other organelles.	Corticosterone	165-179	proopiomelanocortin	Homo sapiens	87-91
15572653-2	2005	Melanocytes express proopiomelanocortin (POMC), corticotropin-releasing hormone (CRH), and CRH receptor-1 (CRH-R1) and can produce corticosterone.	Corticosterone	131-145	corticotropin releasing hormone receptor 1	Homo sapiens	107-113
15572653-4	2005	CRH and ACTH also enhanced production of cortisol and corticosterone, and cortisol production was also stimulated by progesterone.	Corticosterone	54-68	corticotropin releasing hormone	Homo sapiens	0-3
15572653-4	2005	CRH and ACTH also enhanced production of cortisol and corticosterone, and cortisol production was also stimulated by progesterone.	Corticosterone	54-68	proopiomelanocortin	Homo sapiens	8-12
15891025-4	2005	Graded concentrations of frog NT induced a dose-dependent stimulation of corticosterone and aldosterone secretion by frog adrenocortical explants through activation of two receptors with pEC(50) of 9.8 and 6.9.	Corticosterone	73-87	neurotensin	Canis lupus familiaris	30-32
15737954-2	2005	In two contributions to the May 2005 issue of Molecular Pharmacology, amino acid residues within the fourth and tenth transmembrane helices of rat OCT1 are described that contribute to cation and corticosterone binding.	Corticosterone	196-210	solute carrier family 22 member 1	Rattus norvegicus	147-151
15640376-5	2005	The uptake of [14C]pramipexole by rOCT1, rOCT2, and kidney slices was inhibited by procainamide and corticosterone, which are selective inhibitors of rOCT1 and rOCT2, respectively.	Corticosterone	100-114	solute carrier family 22 member 1	Rattus norvegicus	34-39
15640376-5	2005	The uptake of [14C]pramipexole by rOCT1, rOCT2, and kidney slices was inhibited by procainamide and corticosterone, which are selective inhibitors of rOCT1 and rOCT2, respectively.	Corticosterone	100-114	solute carrier family 22 member 2	Rattus norvegicus	41-46
15640376-5	2005	The uptake of [14C]pramipexole by rOCT1, rOCT2, and kidney slices was inhibited by procainamide and corticosterone, which are selective inhibitors of rOCT1 and rOCT2, respectively.	Corticosterone	100-114	solute carrier family 22 member 1	Rattus norvegicus	150-155
15640376-5	2005	The uptake of [14C]pramipexole by rOCT1, rOCT2, and kidney slices was inhibited by procainamide and corticosterone, which are selective inhibitors of rOCT1 and rOCT2, respectively.	Corticosterone	100-114	solute carrier family 22 member 2	Rattus norvegicus	160-165
15640376-6	2005	The IC50 values of procainamide and corticosterone for the uptake of [14C]pramipexole by rOCT1, rOCT2, and kidney slices were 7.7, 167.0, and 47.0 microM and 163.7, 10.7, and 47.7 microM, respectively.	Corticosterone	36-50	solute carrier family 22 member 1	Rattus norvegicus	89-94
15640376-6	2005	The IC50 values of procainamide and corticosterone for the uptake of [14C]pramipexole by rOCT1, rOCT2, and kidney slices were 7.7, 167.0, and 47.0 microM and 163.7, 10.7, and 47.7 microM, respectively.	Corticosterone	36-50	solute carrier family 22 member 2	Rattus norvegicus	96-101
15743993-2	2005	Mineralocorticoid specificity is ensured by 11beta-hydroxysteroid dehydrogenase type 2, which metabolizes cortisol or corticosterone into inactive metabolites that are unable to bind MR and/or GR.	Corticosterone	118-132	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	44-86
15743993-6	2005	At 3 h, the corticosterone dose-response curve was shifted to the right compared with that of aldosterone by more than two log concentrations, an effect that was fully reverted in the presence of the 11beta-hydroxysteroid dehydrogenase type 2 inhibitor carbenoxolone.	Corticosterone	12-26	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	200-242
15725340-7	2005	Therefore, corticosterone potentiates noradrenaline-induced melatonin and NAS production through GR inhibition of NFkappaB nuclear translocation.	Corticosterone	11-25	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	97-99
15752579-7	2005	The hypoxia-increased CRF, CRF mRNA, CRFR1 mRNA, and corticosterone were blocked by CRFR1 antagonist (CP-154,526), suggesting that CRFR1 in PVN and pituitary are responsible for the hypoxia-increased CRF and CRF mRNA in PVN.	Corticosterone	53-67	corticotropin releasing hormone receptor 1	Rattus norvegicus	84-89
15752579-7	2005	The hypoxia-increased CRF, CRF mRNA, CRFR1 mRNA, and corticosterone were blocked by CRFR1 antagonist (CP-154,526), suggesting that CRFR1 in PVN and pituitary are responsible for the hypoxia-increased CRF and CRF mRNA in PVN.	Corticosterone	53-67	corticotropin releasing hormone receptor 1	Rattus norvegicus	84-89
15725416-0	2005	Function of neuropeptide Y and agouti-related protein at weaning: relation to corticosterone, dietary carbohydrate and body weight.	Corticosterone	78-92	neuropeptide Y	Rattus norvegicus	12-26
15725416-0	2005	Function of neuropeptide Y and agouti-related protein at weaning: relation to corticosterone, dietary carbohydrate and body weight.	Corticosterone	78-92	agouti related neuropeptide	Rattus norvegicus	31-53
15725416-1	2005	Neuropeptide Y (NPY) and agouti-related protein (AgRP), potent stimulants of feeding, have been linked in adult rats to both corticosterone (CORT) and dietary carbohydrate.	Corticosterone	125-139	neuropeptide Y	Rattus norvegicus	0-20
15725416-1	2005	Neuropeptide Y (NPY) and agouti-related protein (AgRP), potent stimulants of feeding, have been linked in adult rats to both corticosterone (CORT) and dietary carbohydrate.	Corticosterone	125-139	agouti related neuropeptide	Rattus norvegicus	25-47
15725416-1	2005	Neuropeptide Y (NPY) and agouti-related protein (AgRP), potent stimulants of feeding, have been linked in adult rats to both corticosterone (CORT) and dietary carbohydrate.	Corticosterone	125-139	agouti related neuropeptide	Rattus norvegicus	49-53
15564336-8	2005	Consistent with the latter possibility, phenelzine significantly increased plasma ACTH and paraventricular hypothalamus CRH mRNA in ADX, corticosterone-replaced mice.	Corticosterone	137-151	corticotropin releasing hormone	Mus musculus	120-123
15564338-9	2005	Parvocellular arginine vasopressin mRNA was negatively correlated to basal corticosterone, except in aged-inferior learners.	Corticosterone	75-89	arginine vasopressin	Rattus norvegicus	23-34
15564339-11	2005	Furthermore, we show that SRC-1e but not SRC-1a mRNA expression was regulated in the pituitary by corticosterone.	Corticosterone	98-112	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	26-29
15773051-5	2005	Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions.	Corticosterone	0-14	interleukin 1 alpha	Rattus norvegicus	151-160
15773051-5	2005	Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions.	Corticosterone	16-20	interleukin 1 alpha	Rattus norvegicus	151-160
15652661-0	2005	Effect of corticosterone on CART peptide levels in rat blood.	Corticosterone	10-24	CART prepropeptide	Rattus norvegicus	28-32
15652661-2	2005	This study extends previous findings by directly testing the effects of acute administration of corticosterone and metyrapone on CART peptide levels in blood.	Corticosterone	96-110	CART prepropeptide	Rattus norvegicus	129-133
15652661-3	2005	Acute treatment with corticosterone augmented CART levels, while metyrapone administration prevented the increase in CART in the evening hours.	Corticosterone	21-35	CART prepropeptide	Rattus norvegicus	46-50
15716415-8	2005	Surprisingly, a temporal rise in serum corticosterone was also dependent on TLR4 signaling in nonhematopoietic cells.	Corticosterone	39-53	toll-like receptor 4	Mus musculus	76-80
15716415-9	2005	Our findings demonstrate a requirement for TLR4 function in CNS-resident cells, independent of systemic cytokine effects, for sustained CNS-specific inflammation and corticosterone rise during endotoxemia.	Corticosterone	166-180	toll-like receptor 4	Mus musculus	43-47
15582733-6	2005	The ICV injection of ghrelin increased plasma corticosterone levels in a dose-dependent or a time-dependent manner.	Corticosterone	46-60	ghrelin and obestatin prepropeptide	Rattus norvegicus	21-28
15582733-7	2005	Co-injection of a CRF receptor antagonist, astressin, attenuated ghrelin-induced plasma corticosterone increase and anorexia.	Corticosterone	88-102	ghrelin and obestatin prepropeptide	Rattus norvegicus	65-72
15617770-1	2005	In the present study new-born rats were treated with corticosterone (CORT) between postnatal days 1 and 12.	Corticosterone	53-67	cortistatin	Rattus norvegicus	69-73
15796762-1	2005	Hypoglycaemia induced by insulin injection is a powerful stimulus to the hypothalamic-pituitary-adrenal (HPA) axis and drives the secretion of corticotropin-releasing hormone and vasopressin from the neurones in the paraventricular nucleus (PVN), as well as the downstream hormones, adrenocorticotropic hormone and corticosterone.	Corticosterone	315-329	corticotropin releasing hormone	Rattus norvegicus	143-174
15796762-1	2005	Hypoglycaemia induced by insulin injection is a powerful stimulus to the hypothalamic-pituitary-adrenal (HPA) axis and drives the secretion of corticotropin-releasing hormone and vasopressin from the neurones in the paraventricular nucleus (PVN), as well as the downstream hormones, adrenocorticotropic hormone and corticosterone.	Corticosterone	315-329	arginine vasopressin	Rattus norvegicus	179-190
15631890-5	2005	However, the elevated trough plasma corticosterone levels were no longer evident in rats treated previously with the GR antagonist either alone or in combination with the MR antagonist.	Corticosterone	36-50	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	117-119
15631890-5	2005	However, the elevated trough plasma corticosterone levels were no longer evident in rats treated previously with the GR antagonist either alone or in combination with the MR antagonist.	Corticosterone	36-50	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	171-173
15631890-6	2005	GR activation during stressor exposure appears to be necessary for the development of subsequent basal corticosterone elevations.	Corticosterone	103-117	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	0-2
15906564-7	2005	Serum corticosterone secretion was high before and after ACTH injection, compared with clinically normal dogs and dogs with hypercortisolemia and classic hyperadrenocorticism.	Corticosterone	6-20	proopiomelanocortin	Canis lupus familiaris	57-61
15607734-4	2005	After ghrelin administration, the serum levels of insulin increased only in WT mice whereas the serum levels of corticosterone increased both in WT and MCHr KO mice.	Corticosterone	112-126	ghrelin	Mus musculus	6-13
15742969-9	2005	At 60 min after ACTH injection, corticosterone levels were lower at d 12 than at d 15 and 18.	Corticosterone	32-46	proopiomelanocortin	Homo sapiens	16-20
15742969-10	2005	At 150 min after ACTH injection, corticosterone levels followed different trends according to incubation stage and turning duration.	Corticosterone	33-47	proopiomelanocortin	Homo sapiens	17-21
15742969-12	2005	Also at d 18, corticosterone levels in the T15 group were the highest at 150 min after ACTH injection.	Corticosterone	14-28	proopiomelanocortin	Homo sapiens	87-91
15664315-1	2005	Evaluating corticosterone (CORT) responses to stress in free-living vertebrates requires knowing the unstressed titers prior to capture.	Corticosterone	11-25	cortistatin	Homo sapiens	27-31
15345475-2	2005	Intracerebroventricular (ICV) administration of NPW activated, in a dose-related fashion, the hypothalamic-pituitary-adrenal axis, as determined by plasma corticosterone levels in conscious rats but, at those same doses, did not stimulate the release of oxytocin or vasopressin into the peripheral circulation or alter blood pressure or heart rate.	Corticosterone	155-169	neuropeptide W	Rattus norvegicus	48-51
15331347-0	2005	Diurnal changes in intestinal apolipoprotein A-IV and its relation to food intake and corticosterone in rats.	Corticosterone	86-100	apolipoprotein A4	Rattus norvegicus	30-49
15331347-4	2005	In both FF and FR rats, increased plasma corticosterone (Cort) levels temporally coincided with the increasing phase of intestinal apo A-IV mRNA and protein expression.	Corticosterone	41-55	cortistatin	Rattus norvegicus	57-61
15331347-4	2005	In both FF and FR rats, increased plasma corticosterone (Cort) levels temporally coincided with the increasing phase of intestinal apo A-IV mRNA and protein expression.	Corticosterone	41-55	apolipoprotein A4	Rattus norvegicus	131-139
15476265-4	2005	The BDNF group was protected from the deleterious effects of stress and performed at a level indistinguishable from normal control animals despite the presence of elevated corticosterone.	Corticosterone	172-186	brain-derived neurotrophic factor	Rattus norvegicus	4-8
15642785-6	2005	Steroid assays showed a clear correlation between circulating corticosterone and inner zone mitochondrial MnSOD, but none between aldosterone and glomerulosa MnSOD.	Corticosterone	62-76	superoxide dismutase 2	Rattus norvegicus	106-111
15616008-2	2005	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inactive 11-dehydrocorticosterone into active corticosterone, thus amplifying glucocorticoid receptor-mediated tissue glucocorticoid action, particularly in the liver.	Corticosterone	85-99	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	44-55
15616008-2	2005	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inactive 11-dehydrocorticosterone into active corticosterone, thus amplifying glucocorticoid receptor-mediated tissue glucocorticoid action, particularly in the liver.	Corticosterone	85-99	nuclear receptor subfamily 3, group C, member 1	Mus musculus	144-167
15616008-5	2005	Increased expression of glucocorticoid receptor and 11beta-HSD1 in the liver of db/db mice was correlated with elevated circulating levels of corticosterone, insulin, and blood glu-cose.	Corticosterone	142-156	nuclear receptor subfamily 3, group C, member 1	Mus musculus	24-47
15616008-5	2005	Increased expression of glucocorticoid receptor and 11beta-HSD1 in the liver of db/db mice was correlated with elevated circulating levels of corticosterone, insulin, and blood glu-cose.	Corticosterone	142-156	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	52-63
15616008-7	2005	Addition of corticosterone to db/db mouse primary hepatocytes activated expression of glucocorticoid receptor, 11beta-HSD1, and PEPCK, and these effects were abolished by RU486.	Corticosterone	12-26	nuclear receptor subfamily 3, group C, member 1	Mus musculus	86-109
15616008-7	2005	Addition of corticosterone to db/db mouse primary hepatocytes activated expression of glucocorticoid receptor, 11beta-HSD1, and PEPCK, and these effects were abolished by RU486.	Corticosterone	12-26	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	111-122
15616008-7	2005	Addition of corticosterone to db/db mouse primary hepatocytes activated expression of glucocorticoid receptor, 11beta-HSD1, and PEPCK, and these effects were abolished by RU486.	Corticosterone	12-26	phosphoenolpyruvate carboxykinase 1, cytosolic	Mus musculus	128-133
15959917-7	2005	The glucocorticoid-receptor (GR) antagonist RU 38486 blocked both the effects of corticosterone.	Corticosterone	81-95	nuclear receptor subfamily 3, group C, member 1	Mus musculus	4-27
15959917-7	2005	The glucocorticoid-receptor (GR) antagonist RU 38486 blocked both the effects of corticosterone.	Corticosterone	81-95	nuclear receptor subfamily 3, group C, member 1	Mus musculus	29-31
15589045-7	2005	This study demonstrates that cooperation of endogenous NE and corticosterone are involved in a time-dependent fall or rise of splenic IL-6 secretion.	Corticosterone	62-76	interleukin 6	Mus musculus	134-138
15589047-3	2005	The serum anti-dsDNA IgG2a levels were increased significantly by stress at 19 weeks of age, which was simultaneously accompanied by inhibition of the serum corticosterone elevation.	Corticosterone	157-171	immunoglobulin heavy variable V1-9	Mus musculus	21-26
22605947-8	2005	So noise acts like a stressor and elevates the secretion of the corticosterone, the stress hormone and leptin, the product of the ob gene there is an elevation in leptin levels after noise stress.	Corticosterone	64-78	leptin	Rattus norvegicus	103-109
15365089-4	2005	Furthermore, we show that six out of nine glucocorticoid drugs, corticosterone, and digoxin increased the accumulation of mitoxantrone in the MEF3.8-BCRP cell line, indicating inhibition of BCRP.	Corticosterone	64-78	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	149-153
15365089-4	2005	Furthermore, we show that six out of nine glucocorticoid drugs, corticosterone, and digoxin increased the accumulation of mitoxantrone in the MEF3.8-BCRP cell line, indicating inhibition of BCRP.	Corticosterone	64-78	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	190-194
22605947-8	2005	So noise acts like a stressor and elevates the secretion of the corticosterone, the stress hormone and leptin, the product of the ob gene there is an elevation in leptin levels after noise stress.	Corticosterone	64-78	leptin	Rattus norvegicus	163-169
16020927-11	2005	Additionally, we noted significant correlations between stress-induced plasma corticosterone levels and components of the HPT axis, including TRH mRNA levels and free T4 levels.	Corticosterone	78-92	thyrotropin releasing hormone	Rattus norvegicus	142-145
15809511-10	2005	In AtT20 cells, exposure to corticosterone (10(-7) and 10(-6)M; 24 h) and DEX (10(-9)-10(-6)M) stimulated resistin mRNA more than 65% (p&lt;0.05) and 115% (p&lt;0.0001), respectively.	Corticosterone	28-42	resistin	Mus musculus	106-114
16125856-5	2005	Second, these latter effects were prevented by treating slices with the glucocorticoid receptor antagonist mifepristone prior to and during corticosterone administration.	Corticosterone	140-154	nuclear receptor subfamily 3, group C, member 1	Mus musculus	72-95
15617730-7	2005	Binding studies showed that corticosterone treatment had significantly affected nicotinic acetylcholine receptor (nAChR) density in the mouse brain.	Corticosterone	28-42	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	80-112
15617730-7	2005	Binding studies showed that corticosterone treatment had significantly affected nicotinic acetylcholine receptor (nAChR) density in the mouse brain.	Corticosterone	28-42	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	114-119
15617730-9	2005	These results suggest a possible interaction of corticosterone and nicotine at the level of the alpha4- and alpha7-type nAChR in the regulation of PPI.	Corticosterone	48-62	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	120-125
16125856-8	2005	These results indicate that corticosterone, via glucocorticoid receptor activation, selectively hampers N-methyl-D-aspartate receptor dependent synaptic plasticity in vitro and leaves more complex forms of long term potentiation unaffected.	Corticosterone	28-42	nuclear receptor subfamily 3, group C, member 1	Mus musculus	48-71
15527747-0	2004	Dexamethasone induces different wheel running activity than corticosterone through vasopressin release from the suprachiasmatic nucleus.	Corticosterone	60-74	arginine vasopressin	Homo sapiens	83-94
15893645-5	2005	Circulating levels of adrenocorticotrophin (ACTH) and corticosterone were significantly decreased on postnatal day 1 and this was related to a diminution of HPA axis activity shown by the decrease of central expression of corticotropin releasing hormone (CRH) mRNA, immunoreactive content in paraventricular neurons (PVN) and in the median eminence endings were significantly decreased.	Corticosterone	54-68	corticotropin releasing hormone	Homo sapiens	222-253
15610897-8	2005	It was found that both 10(-4) and 10(-5) mol/L corticosterone (CORT) rapidly inhibited uptake of neutral red by macrophages in less than 30 min, and the inhibition by the former was stronger than that of the latter.	Corticosterone	47-61	cortistatin	Mus musculus	63-67
15590919-7	2004	These results suggest that the effects of stress on LTP and LTD originate from the corticosterone-induced sustained activation of ERK1/2-coupled signaling cascades.	Corticosterone	83-97	mitogen activated protein kinase 3	Rattus norvegicus	130-136
16206879-5	2005	Baseline corticosterone, but not ACTH, concentrations are also altered in the nNOS-/- mice.	Corticosterone	9-23	nitric oxide synthase 1, neuronal	Mus musculus	78-82
16206879-6	2005	Despite elevated corticosterone concentrations, nNOS knockout mice are less "anxious" or "fearful" than WT mice, which may contribute to their aggressiveness.	Corticosterone	17-31	nitric oxide synthase 1, neuronal	Mus musculus	48-52
15509669-8	2005	Immune parameter data from mouse blood indicate that MHC II expression has consistent quantitative relationships to corticosterone AUC values, similar to but less consistent than those observed in the spleen.	Corticosterone	116-130	histocompatibility-2, MHC	Mus musculus	53-59
15527747-3	2004	The corticosterone (0.2 and 2 microg/ml, final concentration in medium) decreased the AVP release, while it increased by dexamethasone (0.2 and 2 microg/ml).	Corticosterone	4-18	arginine vasopressin	Homo sapiens	86-89
15527747-4	2004	An AVP mRNA in the SCN was decreased by both corticosterone (1 mg/100 g) and dexamethasone (0.1 mg/100 g).	Corticosterone	45-59	arginine vasopressin	Homo sapiens	3-6
15527747-5	2004	The differences in wheel activity by corticosterone and dexamethasone are discussed from the changes of AVP in the SCN.	Corticosterone	37-51	arginine vasopressin	Homo sapiens	104-107
15608607-9	2004	The catalase inhibitor cyanamide (45 mg/kg, intraperitoneally) also increased ethanol-related plasma corticosterone levels.	Corticosterone	101-115	catalase	Mus musculus	4-12
15608607-10	2004	These effects of AT and cyanamide on ethanol-induced corticosterone values were observed under treatment conditions that decreased significantly brain catalase activity.	Corticosterone	53-67	catalase	Mus musculus	151-159
15608607-13	2004	CONCLUSIONS: This study shows that the inhibition of brain catalase increases ethanol-induced plasma corticosterone levels.	Corticosterone	101-115	catalase	Mus musculus	59-67
15581807-2	2004	Two trials were conducted to evaluate the effects of short-term administration of corticosterone (CORT) on the induction of oxidative injury in broiler chickens (Gallus gallus domesticus).	Corticosterone	82-96	CORT	Gallus gallus	98-102
15319220-0	2004	Enhanced corticosterone concentrations and attenuated Fos expression in the medial amygdala of female oxytocin knockout mice exposed to psychogenic stress.	Corticosterone	9-23	oxytocin	Mus musculus	102-110
15677436-3	2004	Previously, we found that rises in the corticosterone level, as after acute stressors, enhance the response of hippocampal CA1 neurons to serotonin (5-HT), which hyperpolarizes the membrane via the 5-HT1A receptor.	Corticosterone	39-53	carbonic anhydrase 1	Rattus norvegicus	123-126
15331569-4	2004	to male mice produced a small, dose-dependent increase in the serum corticosterone (CORT) concentration.	Corticosterone	68-82	cortistatin	Mus musculus	84-88
15304373-3	2004	Adrenalectomy (ADX) increased hypothalamic IL-1beta mRNA levels twofold, measured by real-time PCR (P &lt; 0.05 vs. sham-operated controls), and this effect was blocked by subcutaneous infusion of a physiological dose of corticosterone.	Corticosterone	221-235	interleukin 1 beta	Rattus norvegicus	43-51
15304373-5	2004	Moreover, fasting for 48 h (which lowers leptin and raises corticosterone levels) reduced hypothalamic IL-1beta mRNA levels by 30% (P = 0.02), and this decrease was fully reversed by refeeding for 12 h. Thus leptin and GCs exert opposing effects on hypothalamic IL-1beta gene expression, and corticosterone plays a physiological role to limit expression of this cytokine in both the presence and absence of intact leptin signaling.	Corticosterone	59-73	interleukin 1 beta	Rattus norvegicus	103-111
15304373-5	2004	Moreover, fasting for 48 h (which lowers leptin and raises corticosterone levels) reduced hypothalamic IL-1beta mRNA levels by 30% (P = 0.02), and this decrease was fully reversed by refeeding for 12 h. Thus leptin and GCs exert opposing effects on hypothalamic IL-1beta gene expression, and corticosterone plays a physiological role to limit expression of this cytokine in both the presence and absence of intact leptin signaling.	Corticosterone	292-306	interleukin 1 beta	Rattus norvegicus	103-111
15304373-7	2004	These data support a model in which expression of hypothalamic IL-1beta is subject to opposing physiological regulation by corticosterone and leptin.	Corticosterone	123-137	interleukin 1 beta	Rattus norvegicus	63-71
15667452-1	2004	We examined the extent to which basal levels of corticosterone, which vary in a circadian fashion, influence the pattern of Fos protein expression in the paraventricular nucleus of the hypothalamus (PVN), the hippocampal formation and three different functional cortical areas.	Corticosterone	48-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	124-127
15549684-2	2004	In this study, the corticosterone (CORT) response to a stressor (saline injection ip) on postnatal Day 12 was assessed in rat pups that had been either dam-reared (DR) or artificially reared since Day 5.	Corticosterone	19-33	cortistatin	Rattus norvegicus	35-39
15555498-7	2004	Pilot studies of scrub-jays in suburban environments suggest that the spatial and temporal predictability of food may influence corticosterone (CORT) levels.	Corticosterone	128-142	cortistatin	Homo sapiens	144-148
15555508-4	2004	We compared concentrations of T, dehydroepiandrosterone (DHEA; a precursor of T), and corticosterone (Cort; a stress hormone) of chicks at various stages.	Corticosterone	86-100	CORT	Gallus gallus	102-106
15590977-0	2004	Exocytosis sensitivity to growth hormone-releasing hormone in subsets of GH cells in rats under different corticosterone conditions.	Corticosterone	106-120	growth hormone releasing hormone	Rattus norvegicus	26-58
15590977-10	2004	Corticosterone replacement given to ADX rats induced a clear recovery of the exocytotic response to GRH to the control level.	Corticosterone	0-14	growth hormone releasing hormone	Rattus norvegicus	100-103
15667452-9	2004	Corticosterone replacement normalized the adrenalectomy effect on Fos expression in both brain regions.	Corticosterone	0-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
15638087-5	2004	Corticosterone levels of all groups were found to be elevated after stress compared to group C. Cu, Zn-SOD activity was lower in all stress groups than in group C. CAT and Se-GSH-Px activities were increased in all stress groups.	Corticosterone	0-14	catalase	Rattus norvegicus	164-167
15530658-9	2004	Finally, immobilization stress significantly increased serum corticosterone levels in both genotypes at 30 min and 2 h, with Fmr1-KOs exhibiting greater levels than WTs; levels were statistically different at 2 h. These data indicate a greater response to stress in FraX mutants than in WTs, and further support the hypothesis of a dysregulated hypothalamic-pituitary-adrenal (HPA) axis in FraX syndrome.	Corticosterone	61-75	fragile X messenger ribonucleoprotein 1	Mus musculus	125-129
15546996-3	2004	Here, we demonstrate that TLR-2 deficiency in mice is associated with reduced plasma corticosterone levels and marked cellular alterations in adrenocortical tissue.	Corticosterone	85-99	toll-like receptor 2	Mus musculus	26-31
15491790-5	2004	injection of 12.5 ng of IL-1beta caused significant changes in plasma corticosterone, as compared to basal levels.	Corticosterone	70-84	interleukin 1 beta	Homo sapiens	24-32
15491790-6	2004	The treatment with gamma-MSH (1 microg), an MC3 receptor agonist, resulted in significant reduction of the IL-1beta-induced plasma corticosterone levels.	Corticosterone	131-145	proopiomelanocortin	Homo sapiens	19-28
15491790-6	2004	The treatment with gamma-MSH (1 microg), an MC3 receptor agonist, resulted in significant reduction of the IL-1beta-induced plasma corticosterone levels.	Corticosterone	131-145	interleukin 1 beta	Homo sapiens	107-115
15491790-8	2004	Besides, treatment with a high dose of alpha-MSH (1 microg) increased plasma corticosterone.	Corticosterone	77-91	proopiomelanocortin	Homo sapiens	39-48
15491790-9	2004	When alpha-MSH was given at a lower dose (0.1 microg), it did not modify corticosterone levels but caused an inhibitory effect on the corticosterone release induced by IL-1beta.	Corticosterone	134-148	proopiomelanocortin	Homo sapiens	5-14
15491790-9	2004	When alpha-MSH was given at a lower dose (0.1 microg), it did not modify corticosterone levels but caused an inhibitory effect on the corticosterone release induced by IL-1beta.	Corticosterone	134-148	interleukin 1 beta	Homo sapiens	168-176
15679929-12	2004	RESULTS: Both isoforms of MTmRNA and IL-6mRNA increase in old thymus coupled with low zinc ion bioavailability, reduced TECs proliferation, impaired thymulin activity and enhanced plasma corticosterone in comparison with young.	Corticosterone	187-201	interleukin 6	Mus musculus	37-41
15546996-4	2004	TLR-2-deficient mice have an impaired adrenal corticosterone release after inflammatory stress induced by bacterial cell wall compounds.	Corticosterone	46-60	toll-like receptor 2	Mus musculus	0-5
15271883-5	2004	Central administration of CART(55-102) (1 microg) significantly increased circulating levels of ACTH (481 +/- 122 vs. 93 +/- 14 pg/ml; CART vs. vehicle) and corticosterone (460 +/- 29 vs. 179 +/- 62 ng/ml; CART vs. vehicle).	Corticosterone	157-171	CART prepropeptide	Rattus norvegicus	26-30
15666850-4	2004	Corticosterone secretion (RIA) in serum-free medium was stimulated over 12-fold after 6 h treatment with either 10(-9)M ACTH or PRL and both hormones seemed equivalent in promoting this secretion (149 +/- 14 ng and 145 +/- 18 ng/10(6) cells/6 h, respectively).	Corticosterone	0-14	pro-opiomelanocortin-alpha	Mus musculus	120-124
15666850-5	2004	As expected, Northern blots indicate that ATC1 cells expressed mRNAs for the enzymes of corticosterone metabolism CYP11B1 and CYP21A, as well as those for the proteins SIK, SRB1, StAR, CYP11A1, and AKR1B7.	Corticosterone	88-102	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	114-121
15465537-3	2004	These studies examined the possibility that prolactin"s orexigenic effects are mediated through the increased secretion of corticosterone.	Corticosterone	123-137	prolactin	Homo sapiens	44-53
15465537-4	2004	Twice-daily intracerebroventricular (icv) injection of prolactin increased plasma corticosterone concentration in non-breeding doves of both sexes, with males exhibiting more pronounced effects than females.	Corticosterone	82-96	prolactin	Homo sapiens	55-64
15465537-7	2004	These findings suggest that elevated corticosterone titers in blood may contribute to the hyperphagia observed in response to prolactin, but corticosterone signaling through a mammalian-type glucocorticoid receptor is not essential.	Corticosterone	37-51	prolactin	Homo sapiens	126-135
15271883-8	2004	Injection of Astressin B (50 microg/kg, iv) inhibited CART(55-102)-induced ACTH and corticosterone responses.	Corticosterone	84-98	CART prepropeptide	Rattus norvegicus	54-58
15492859-0	2004	Effects of leptin and leptin fragments on corticosterone secretion and growth of cultured rat adrenocortical cells.	Corticosterone	42-56	leptin	Rattus norvegicus	22-28
15477372-1	2004	Physical and psychosocial stress challenge homeostasis, increasing glucocorticoid secretion (in rodents, corticosterone [CORT]) while decreasing testosterone (T) levels.	Corticosterone	105-119	cortistatin	Mus musculus	121-125
15492859-7	2004	Leptin fragments 150-167 and 26-39 stimulated corticosterone production, and fragments 138-167 and 22-56 inhibited it.	Corticosterone	46-60	leptin	Rattus norvegicus	0-6
15465594-0	2004	Overproduction of corticotropin-releasing hormone blocks germinal center formation: role of corticosterone and impaired follicular dendritic cell networks.	Corticosterone	92-106	corticotropin releasing hormone	Mus musculus	18-49
15584929-10	2004	Plasma corticosterone was significantly elevated by 30 min after exposure to the stressor and continued to increase up to 6 h. Morphometric analysis of CRH-ir after 4 h of stress showed a significant increase in CRH-ir in parvocellular neurones of the anterior preoptic area, the medial amygdala and the bed nucleus of the stria terminalis, but not in other brain regions.	Corticosterone	7-21	corticotropin releasing hormone L homeolog	Xenopus laevis	152-155
15584929-10	2004	Plasma corticosterone was significantly elevated by 30 min after exposure to the stressor and continued to increase up to 6 h. Morphometric analysis of CRH-ir after 4 h of stress showed a significant increase in CRH-ir in parvocellular neurones of the anterior preoptic area, the medial amygdala and the bed nucleus of the stria terminalis, but not in other brain regions.	Corticosterone	7-21	corticotropin releasing hormone L homeolog	Xenopus laevis	212-215
15518636-4	2004	After central administration of excess Ang II, the reduction of ACTH and corticosterone release induced by AT(1) receptor blockade no longer occurred.	Corticosterone	73-87	angiotensinogen	Rattus norvegicus	39-45
15646207-8	2004	The adrenal threshold sensitivity and reaction to exogenous ACTH in vivo suggests that increased corticosterone reaction to emotional stress is caused by increased pituitary stimulation.	Corticosterone	97-111	pro-opiomelanocortin-alpha	Mus musculus	60-64
15525497-8	2004	Concordant with the human phenotype, Tpit-null mice have IAD : plasma ACTH is greatly reduced in these mice, their plasma corticosterone is undetectable and the adrenals are hypoplastic.	Corticosterone	122-136	T-box transcription factor 19	Homo sapiens	37-41
15454346-4	2004	Basal and novelty stress-induced plasma levels of adrenocorticotropin (ACTH) and corticosterone were higher in CB1-KO than in WT mice.	Corticosterone	81-95	cannabinoid receptor 1 (brain)	Mus musculus	111-114
15381067-6	2004	In primary cultured mouse hepatocytes, CYP2B9 mRNA expression was concentration-dependently suppressed by natural glucocorticoids such as hydrocortisone and corticosterone as well as by DEX.	Corticosterone	157-171	cytochrome P450, family 2, subfamily b, polypeptide 9	Mus musculus	39-45
15519888-3	2004	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyses the regeneration of active glucocorticoids (cortisol and corticosterone) from inert 11-keto forms in specific tissues, notably liver, adipose and brain.	Corticosterone	124-138	RNA, U1 small nuclear 1	Homo sapiens	0-55
15231703-6	2004	Heterozygous mice (Pomc+/-) had smaller adrenal glands with significantly lower levels of corticosterone both basally and in response to CRH and ACTH than wild-type mice, indicating that two functional copies of the Pomc gene are necessary to support the fully normal function of the hypothalamic-pituitary-adrenal axis.	Corticosterone	90-104	pro-opiomelanocortin-alpha	Mus musculus	19-23
15351702-2	2004	Acute administration of NMU into the paraventricular nuclei (iPVN) increases plasma adrenocorticotrophic hormone and corticosterone, and inhibits food intake in fasted rats.	Corticosterone	117-131	neuromedin U	Rattus norvegicus	24-27
15351702-6	2004	Chronic iPVN NMU produced a typical behavioral response on day 1 and day 4 of the study, and resulted in the elevation of plasma corticosterone present 18 h after the final injection.	Corticosterone	129-143	neuromedin U	Rattus norvegicus	13-16
15361361-11	2004	In contrast, thyroid hormone and corticosterone increased Ntcp mRNA in hypophysectomized rats.	Corticosterone	33-47	solute carrier family 10 member 1	Rattus norvegicus	58-62
15361361-12	2004	Sex differences in Ntcp mRNA levels were produced only when the female pattern of growth hormone was administered to animals also receiving thyroid and corticosterone.	Corticosterone	152-166	solute carrier family 10 member 1	Rattus norvegicus	19-23
15361361-12	2004	Sex differences in Ntcp mRNA levels were produced only when the female pattern of growth hormone was administered to animals also receiving thyroid and corticosterone.	Corticosterone	152-166	gonadotropin releasing hormone receptor	Rattus norvegicus	82-96
15231703-6	2004	Heterozygous mice (Pomc+/-) had smaller adrenal glands with significantly lower levels of corticosterone both basally and in response to CRH and ACTH than wild-type mice, indicating that two functional copies of the Pomc gene are necessary to support the fully normal function of the hypothalamic-pituitary-adrenal axis.	Corticosterone	90-104	corticotropin releasing hormone	Mus musculus	137-140
15231703-6	2004	Heterozygous mice (Pomc+/-) had smaller adrenal glands with significantly lower levels of corticosterone both basally and in response to CRH and ACTH than wild-type mice, indicating that two functional copies of the Pomc gene are necessary to support the fully normal function of the hypothalamic-pituitary-adrenal axis.	Corticosterone	90-104	pro-opiomelanocortin-alpha	Mus musculus	145-149
15231703-10	2004	Although such glands are atrophic and hypofunctional, exposure to ACTH alone can restore their size, morphology, and corticosterone secretion.	Corticosterone	117-131	pro-opiomelanocortin-alpha	Mus musculus	66-70
15500544-8	2004	Pretreatment with a polyclonal anti-CRF antiserum completely blocked the ability of NPB to stimulate ACTH release and significantly inhibited the effect of NPB on plasma corticosterone levels.	Corticosterone	170-184	neuropeptide B	Rattus norvegicus	156-159
15380328-5	2004	Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions.	Corticosterone	0-14	interleukin 1 alpha	Rattus norvegicus	151-160
15380328-5	2004	Corticosterone (CORT) or dexamethasone (DEX) supplementation not only cancelled effects of ADX, but also partially reversed TMT-induced enhancement of IL-1alpha/beta expressions.	Corticosterone	16-20	interleukin 1 alpha	Rattus norvegicus	151-160
15138156-7	2004	Furthermore, CART-IR content and plasma CART-IR were significantly increased in adrenalectomized rats, and anterior pituitary CART mRNA expression, CART-IR content, and plasma CART-IR were significantly decreased in corticosterone-treated rats.	Corticosterone	216-230	CART prepropeptide	Rattus norvegicus	13-17
15588378-2	2004	Inhibition of thyrotropin (TSH) and MSH secretion by pituitary preparations by adding exogenous TSH or MSH to the medium was already observed in the 1960s, as was the phenomenon that adrenocorticotropic hormone (ACTH) injected in the hypothalamus lowered plasma corticosterone levels.	Corticosterone	262-276	proopiomelanocortin	Homo sapiens	183-210
15138156-8	2004	Plasma CART-IR showed a pattern of diurnal variation similar to that of ACTH and corticosterone, and plasma CART-IR was positively correlated with corticosterone.	Corticosterone	147-161	CART prepropeptide	Rattus norvegicus	108-112
15155577-6	2004	Adrenalectomy caused a 70% reduction in CART peptide levels in rat blood, and this was reversed by corticosterone replacement.	Corticosterone	99-113	CART prepropeptide	Rattus norvegicus	40-44
15155577-8	2004	Control of CART levels by corticosterone suggests the possibility that CART peptides in blood may be influenced by hypothalamic-pituitary-adrenal interactions and that they may play a role in glucocorticoid-related processes such as stress.	Corticosterone	26-40	CART prepropeptide	Rattus norvegicus	11-15
15155577-8	2004	Control of CART levels by corticosterone suggests the possibility that CART peptides in blood may be influenced by hypothalamic-pituitary-adrenal interactions and that they may play a role in glucocorticoid-related processes such as stress.	Corticosterone	26-40	CART prepropeptide	Rattus norvegicus	71-75
15589266-3	2004	Today it is generally accepted that parvocellular neurones of the hypothalamic paraventricular nucleus control the secretion of corticotropin and corticosterone by synthesising and releasing both the corticotropin-releasing hormone and vasopressin (AVP).	Corticosterone	146-160	corticotropin releasing hormone	Homo sapiens	200-231
15589266-3	2004	Today it is generally accepted that parvocellular neurones of the hypothalamic paraventricular nucleus control the secretion of corticotropin and corticosterone by synthesising and releasing both the corticotropin-releasing hormone and vasopressin (AVP).	Corticosterone	146-160	arginine vasopressin	Homo sapiens	236-247
15113846-4	2004	In contrast, both NCX-1015 and prednisolone reduced plasma levels of corticosterone in a dose- (dose range of 0.69-6.9 micromol/kg i.p.)	Corticosterone	69-83	solute carrier family 8 member A1	Rattus norvegicus	18-21
15184356-0	2004	Stress-induced pressor and corticosterone responses in oxytocin-deficient mice.	Corticosterone	27-41	oxytocin	Mus musculus	55-63
15381835-13	2004	), a selective inducible nitric oxide synthase (iNOS) inhibitor, considerably enhanced ACTH and corticosterone secretion induced by a lower dose (0.5 mg/kg) of LPS and did not significantly alter this secretion after a larger dose (1 mg/kg) of LPS.	Corticosterone	96-110	nitric oxide synthase 2	Rattus norvegicus	15-46
15381835-13	2004	), a selective inducible nitric oxide synthase (iNOS) inhibitor, considerably enhanced ACTH and corticosterone secretion induced by a lower dose (0.5 mg/kg) of LPS and did not significantly alter this secretion after a larger dose (1 mg/kg) of LPS.	Corticosterone	96-110	nitric oxide synthase 2	Rattus norvegicus	48-52
15306120-1	2004	The effects of corticosterone (CORT) and dehydroepiandrosterone (DHEA) on the expression of growth factor mRNA in either primary hippocampal cultures or astrocyte-enriched cultures from E18 CD rats was studied.	Corticosterone	15-29	myotrophin	Rattus norvegicus	92-105
15383256-4	2004	(2) Pro-apoptotic genes such as Fas, FasL, TNFR1, and Bax displayed increased expression level in corticosterone-treated group compared with normal control group.	Corticosterone	98-112	Fas ligand	Rattus norvegicus	37-41
15383256-4	2004	(2) Pro-apoptotic genes such as Fas, FasL, TNFR1, and Bax displayed increased expression level in corticosterone-treated group compared with normal control group.	Corticosterone	98-112	TNF receptor superfamily member 1A	Rattus norvegicus	43-48
15383256-4	2004	(2) Pro-apoptotic genes such as Fas, FasL, TNFR1, and Bax displayed increased expression level in corticosterone-treated group compared with normal control group.	Corticosterone	98-112	BCL2 associated X, apoptosis regulator	Rattus norvegicus	54-57
15383256-8	2004	(3) The activities of caspase-8 and caspase-3 were increased in corticosterone-treated rats compared with normal control; both kidney-tonifying recipes had significant effect on decreasing the activities of these two apoptosis executioners.	Corticosterone	64-78	caspase 8	Rattus norvegicus	22-31
15383256-8	2004	(3) The activities of caspase-8 and caspase-3 were increased in corticosterone-treated rats compared with normal control; both kidney-tonifying recipes had significant effect on decreasing the activities of these two apoptosis executioners.	Corticosterone	64-78	caspase 3	Rattus norvegicus	36-45
15383256-10	2004	Down-regulating the expression of FasL and TNFR1 and up-regulating the expression of Bcl-2 as well as decreasing the activities of caspase-8 and caspase-3 may be the unique regulating pattern of tonifying-kidney method with respect to T cell apoptosis related genes in corticosterone-treated rats.	Corticosterone	269-283	Fas ligand	Rattus norvegicus	34-38
15383256-10	2004	Down-regulating the expression of FasL and TNFR1 and up-regulating the expression of Bcl-2 as well as decreasing the activities of caspase-8 and caspase-3 may be the unique regulating pattern of tonifying-kidney method with respect to T cell apoptosis related genes in corticosterone-treated rats.	Corticosterone	269-283	BCL2, apoptosis regulator	Rattus norvegicus	85-90
15383256-10	2004	Down-regulating the expression of FasL and TNFR1 and up-regulating the expression of Bcl-2 as well as decreasing the activities of caspase-8 and caspase-3 may be the unique regulating pattern of tonifying-kidney method with respect to T cell apoptosis related genes in corticosterone-treated rats.	Corticosterone	269-283	caspase 8	Rattus norvegicus	131-140
15383256-10	2004	Down-regulating the expression of FasL and TNFR1 and up-regulating the expression of Bcl-2 as well as decreasing the activities of caspase-8 and caspase-3 may be the unique regulating pattern of tonifying-kidney method with respect to T cell apoptosis related genes in corticosterone-treated rats.	Corticosterone	269-283	caspase 3	Rattus norvegicus	145-154
15177926-4	2004	Firstly, we found that ICV injections of PACAP and VIP increased plasma corticosterone concentrations.	Corticosterone	72-86	adenylate cyclase activating polypeptide 1	Gallus gallus	41-46
15177926-4	2004	Firstly, we found that ICV injections of PACAP and VIP increased plasma corticosterone concentrations.	Corticosterone	72-86	vasoactive intestinal peptide	Gallus gallus	51-54
15177926-5	2004	The corticosterone-releasing effect of PACAP was completely attenuated by co-injection of astressin, a CRF receptor antagonist, but this effect was only partial for VIP.	Corticosterone	4-18	adenylate cyclase activating polypeptide 1	Gallus gallus	39-44
15177926-7	2004	This difference may arise from the two peptides interacting with different receptors because the corticosterone-releasing effect of PACAP, but not VIP, was completely attenuated by co-injection of PACAP (6-38), a PACAP receptor antagonist.	Corticosterone	97-111	adenylate cyclase activating polypeptide 1	Gallus gallus	132-137
15177926-7	2004	This difference may arise from the two peptides interacting with different receptors because the corticosterone-releasing effect of PACAP, but not VIP, was completely attenuated by co-injection of PACAP (6-38), a PACAP receptor antagonist.	Corticosterone	97-111	adenylate cyclase activating polypeptide 1	Gallus gallus	197-202
15177926-7	2004	This difference may arise from the two peptides interacting with different receptors because the corticosterone-releasing effect of PACAP, but not VIP, was completely attenuated by co-injection of PACAP (6-38), a PACAP receptor antagonist.	Corticosterone	97-111	adenylate cyclase activating polypeptide 1	Gallus gallus	197-202
15357442-12	2004	Adrenocortical cells within PHB can survive a period of time and can secrete corticosterone and aldosterone which can meet the needs of the adrenalectomized rats.	Corticosterone	77-91	prohibitin 1	Rattus norvegicus	28-31
15261759-1	2004	High concentration of corticosterone (Cort) 0.2 mM was incubated with PC12 cells to simulate the lesion state of brain neurons in depressive illness, it was found that the inulin-type oligosaccharides extracted from Morinda officinalis, inulin-type hexasaccharide (IHS) at the doses of 0.625, 1.25 microM or desipramine (DIM) 0.25, 1 microM protected the PC12 cells from the lesion induced by Cort.	Corticosterone	22-36	cortistatin	Rattus norvegicus	38-42
15261759-1	2004	High concentration of corticosterone (Cort) 0.2 mM was incubated with PC12 cells to simulate the lesion state of brain neurons in depressive illness, it was found that the inulin-type oligosaccharides extracted from Morinda officinalis, inulin-type hexasaccharide (IHS) at the doses of 0.625, 1.25 microM or desipramine (DIM) 0.25, 1 microM protected the PC12 cells from the lesion induced by Cort.	Corticosterone	22-36	cortistatin	Rattus norvegicus	393-397
15044377-5	2004	However, corticosterone responses in CRH-Ab-treated animals remained apparent in mice infected with low-dose MCMV and were robust in mice infected with high-dose MCMV.	Corticosterone	9-23	corticotropin releasing hormone	Mus musculus	37-40
15044377-6	2004	CRH-knockout (KO) mice exhibited robust corticosterone responses to both MCMV doses, despite reduced baseline and MCMV-induced ACTH.	Corticosterone	40-54	corticotropin releasing hormone	Mus musculus	0-3
15044377-7	2004	Interestingly, robust corticosterone responses in CRH-Ab-treated and CRH-KO mice were associated with exaggerated IL-6 levels, and IL-6 and corticosterone concentrations in infected CRH-Ab-treated animals were significantly correlated.	Corticosterone	22-36	corticotropin releasing hormone	Mus musculus	50-53
15044377-7	2004	Interestingly, robust corticosterone responses in CRH-Ab-treated and CRH-KO mice were associated with exaggerated IL-6 levels, and IL-6 and corticosterone concentrations in infected CRH-Ab-treated animals were significantly correlated.	Corticosterone	22-36	corticotropin releasing hormone	Mus musculus	69-72
15044377-7	2004	Interestingly, robust corticosterone responses in CRH-Ab-treated and CRH-KO mice were associated with exaggerated IL-6 levels, and IL-6 and corticosterone concentrations in infected CRH-Ab-treated animals were significantly correlated.	Corticosterone	22-36	interleukin 6	Mus musculus	114-118
15044377-7	2004	Interestingly, robust corticosterone responses in CRH-Ab-treated and CRH-KO mice were associated with exaggerated IL-6 levels, and IL-6 and corticosterone concentrations in infected CRH-Ab-treated animals were significantly correlated.	Corticosterone	22-36	corticotropin releasing hormone	Mus musculus	69-72
15044377-8	2004	Neutralization of IL-6 responses in infected CRH-KO mice reduced corticosterone responses by approximately 70%.	Corticosterone	65-79	interleukin 6	Mus musculus	18-22
15044377-8	2004	Neutralization of IL-6 responses in infected CRH-KO mice reduced corticosterone responses by approximately 70%.	Corticosterone	65-79	corticotropin releasing hormone	Mus musculus	45-48
15296483-4	2004	DESIGN AND METHODS: In order to evaluate the HPA function, activating (15-min restriction, ACTH-induced corticosterone production in vitro) and inhibiting (i.p.	Corticosterone	104-118	pro-opiomelanocortin-alpha	Mus musculus	91-95
15044362-6	2004	Replacement of corticosterone in the drinking water of ADX rats reversed the effects of ADX on MCH sensitivity.	Corticosterone	15-29	oleoyl-ACP hydrolase	Rattus norvegicus	95-98
15380840-3	2004	The behavioral emergence of fear is correlated with two physiological events: functional emergence of the amygdala and increasing corticosterone (CORT) levels.	Corticosterone	130-144	cortistatin	Homo sapiens	146-150
15138620-5	2004	Radioimmuno assay demonstrated that leptin enhanced plasma aldosterone and corticosterone concentrations, decreased plasma insulin concentration, and did not significantly affect glucagon plasma concentration.	Corticosterone	75-89	leptin	Rattus norvegicus	36-42
15044432-3	2004	We investigated whether 5alpha-reduced metabolites of corticosterone are glucocorticoid receptor (GR) agonists.	Corticosterone	54-68	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	73-96
15044432-3	2004	We investigated whether 5alpha-reduced metabolites of corticosterone are glucocorticoid receptor (GR) agonists.	Corticosterone	54-68	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	98-100
15084440-2	2004	Female rats are known to have higher basal serum corticosterone (CORT) levels and to manifest a more rapid and stronger CORT response to novel stressors.	Corticosterone	49-63	cortistatin	Rattus norvegicus	65-69
15095041-5	2004	Transgenic mice with selective overexpression in adipose tissue of 11 beta HSD-1 to levels seen in humans develop visceral obesity, hyperlipidaemia and insulin-resistant diabetes associated with a 2.7-fold increase in corticosterone levels in portal compared to peripheral circulation.	Corticosterone	218-232	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	67-80
15117339-9	2004	In both strains, the administration of ACTH in addition to injection stress did not provoke a further increase in DLC concentrations while inducing a significant increase in plasma corticosterone concentration.	Corticosterone	181-195	pro-opiomelanocortin-alpha	Mus musculus	39-43
15117341-5	2004	Corticosterone replacement partially prevented the increases in ERbeta mRNA expression in magnocellular PVN and SON neurones.	Corticosterone	0-14	estrogen receptor 2	Rattus norvegicus	64-70
15082020-1	2004	Glucocorticoid receptor activation within the basolateral amygdala (BLA) during fear conditioning may mediate enhancement in rats chronically exposed to stress levels of corticosterone.	Corticosterone	170-184	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	0-23
15082020-2	2004	Male Sprague-Dawley rats received corticosterone (400 microg/ml) in their drinking water (days 1-21), a manipulation that was previously shown to cause hippocampal CA3 dendritic retraction.	Corticosterone	34-48	carbonic anhydrase 3	Rattus norvegicus	164-167
15159132-7	2004	Interestingly, the levels of several hormones were significantly altered in SSAT transgenic mice; circulating adrenocorticotropic hormone (ACTH) and corticosterone levels were markedly increased while testosterone and thyroidal hormone levels were decreased.	Corticosterone	149-163	spermidine/spermine N1-acetyl transferase 1	Mus musculus	76-80
15063783-4	2004	Corticosterone (2 microM) significantly decreased the number of bromodeoxyuridine-labeled cells (about 50%) and caused the dendritic atrophy in microtubule-associated protein 2-labeled cells.	Corticosterone	0-14	microtubule associated protein 2	Homo sapiens	144-176
15063783-5	2004	The expressions of NeuroD, BDNF, and NR1 mRNA levels and protein levels of p-ERK and p-CREB were remarkably decreased by corticosterone in a dose-dependent manner.	Corticosterone	121-135	neuronal differentiation 1	Homo sapiens	19-25
15063783-5	2004	The expressions of NeuroD, BDNF, and NR1 mRNA levels and protein levels of p-ERK and p-CREB were remarkably decreased by corticosterone in a dose-dependent manner.	Corticosterone	121-135	brain derived neurotrophic factor	Homo sapiens	27-31
15063783-5	2004	The expressions of NeuroD, BDNF, and NR1 mRNA levels and protein levels of p-ERK and p-CREB were remarkably decreased by corticosterone in a dose-dependent manner.	Corticosterone	121-135	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	37-40
15063783-5	2004	The expressions of NeuroD, BDNF, and NR1 mRNA levels and protein levels of p-ERK and p-CREB were remarkably decreased by corticosterone in a dose-dependent manner.	Corticosterone	121-135	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	75-80
14759555-8	2004	Plasma corticosterone levels were higher in the CRH 300 microg/kg group than in the normal saline group at 4 h (P=0.03).	Corticosterone	7-21	corticotropin releasing hormone	Rattus norvegicus	48-51
15113251-2	2004	This sensitive period is coincident with low endogenous corticosterone (CORT) levels and stress hyporesponsivity.	Corticosterone	56-70	cortistatin	Homo sapiens	72-76
14691016-4	2004	In isolated adrenocortical cells from as early as postnatal d 5 (PND5) and throughout the neonatal period, acute (2.5 h) incubation with leptin significantly inhibited ACTH-stimulated corticosterone and aldosterone secretion without affecting cAMP production.	Corticosterone	184-198	leptin	Rattus norvegicus	137-143
14691016-5	2004	In PND10 pups, 24-h maternal separation and the resulting rapid decline in plasma leptin levels increased basal corticosterone and aldosterone secretion in vivo and in isolated cells, but did not modify the ability of leptin to inhibit stimulated steroid production in vitro.	Corticosterone	112-126	leptin	Rattus norvegicus	82-88
14691016-9	2004	These results indicate that leptin inhibits ACTH-stimulated secretion of corticosterone and aldosterone, at least through a rapid reduction in the expression of StAR and PBR protein in the neonatal adrenal gland.	Corticosterone	73-87	leptin	Rattus norvegicus	28-34
15510547-2	2004	Some of these changes are due to hormonal changes involving corticosterone (CORT), triiodothyronine (T3), and thyroxine (T4).	Corticosterone	60-74	CORT	Gallus gallus	76-80
15033910-6	2004	A continuous peripheral CRH infusion to Crh(-/-) mice not only restored corticosterone levels, but it also increased leptin expression to normal.	Corticosterone	72-86	corticotropin releasing hormone	Mus musculus	24-27
15033910-6	2004	A continuous peripheral CRH infusion to Crh(-/-) mice not only restored corticosterone levels, but it also increased leptin expression to normal.	Corticosterone	72-86	corticotropin releasing hormone	Mus musculus	40-43
15033910-8	2004	This abnormal leptin change during fasting in Crh(-/-) mice was corrected by corticosterone replacement.	Corticosterone	77-91	corticotropin releasing hormone	Mus musculus	46-49
15059955-0	2004	Diurnal rhythm of apolipoprotein A-IV in rat hypothalamus and its relation to food intake and corticosterone.	Corticosterone	94-108	apolipoprotein A4	Rattus norvegicus	18-37
15059955-5	2004	Although corticosterone (CORT) secretion temporally coincided with the decreasing phase of apo A-IV in the hypothalamus, depletion of CORT by adrenalectomy significantly decreased, rather than increased, hypothalamic apo A-IV mRNA and protein levels.	Corticosterone	9-23	apolipoprotein A4	Rattus norvegicus	91-99
15059955-5	2004	Although corticosterone (CORT) secretion temporally coincided with the decreasing phase of apo A-IV in the hypothalamus, depletion of CORT by adrenalectomy significantly decreased, rather than increased, hypothalamic apo A-IV mRNA and protein levels.	Corticosterone	25-29	apolipoprotein A4	Rattus norvegicus	91-99
15194873-0	2004	Corticosterone strongly increases the affinity of dorsal raphe 5-HT1A receptors.	Corticosterone	0-14	5-hydroxytryptamine receptor 1A	Rattus norvegicus	63-69
15194873-3	2004	Corticosterone increases 5-HT1A autoreceptor agonist affinity (+90%, p&lt;0.001) in adrenalectomized rats.	Corticosterone	0-14	5-hydroxytryptamine receptor 1A	Rattus norvegicus	25-31
15194873-5	2004	Dorsal raphe glucocorticoid receptors activation by corticosterone may therefore lead to an increased signalling of 5-HT1A autoreceptors that may become counteracted by galanin receptor activation.	Corticosterone	52-66	5-hydroxytryptamine receptor 1A	Rattus norvegicus	116-122
15240353-2	2004	Activation of 5-HT(1A) and 5-HT(2A) receptors increases plasma corticosterone levels, and it is likely that these receptor subtypes are central to mediating the effects of SSRIs.	Corticosterone	63-77	5-hydroxytryptamine receptor 1A	Rattus norvegicus	14-21
15240386-6	2004	The alterations in protein expression may be modulated by the high corticosterone levels that downregulate the glucocorticoid receptor.	Corticosterone	67-81	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	111-134
15148266-2	2004	The aim of the present study was to investigate the effect of different circulating levels of the adrenal steroid corticosterone (CORT) on locomotor hyperactivity and prepulse inhibition of acoustic startle, two behavioural animal models of aspects of schizophrenia.	Corticosterone	114-128	cortistatin	Mus musculus	130-134
15044359-2	2004	Physiologically appropriate concentrations of naturally secreted corticosteroids (cortisol in humans, corticosterone in rats) have major stimulatory effects on caloric intake and, in the presence of insulin, preference.	Corticosterone	102-116	insulin	Homo sapiens	199-206
15215043-1	2004	Current research in birds suggests that a conflict should exist during reproduction for the role of the glucocorticoid corticosterone (CORT).	Corticosterone	119-133	CORT	Gallus gallus	135-139
15171698-5	2004	On the other hand, ADX markedly enhanced the inhibitory effect of TNF-alpha on the LH surge and subsequent ovulation, which was almost completely restored by pretreatment with a subcutaneous injection of corticosterone (10 mg).	Corticosterone	204-218	tumor necrosis factor	Rattus norvegicus	66-75
14699427-0	2004	Ethyl-eicosapentaenoic acid ingestion prevents corticosterone-mediated memory impairment induced by central administration of interleukin-1beta in rats.	Corticosterone	47-61	interleukin 1 beta	Rattus norvegicus	126-143
14699427-1	2004	Central or peripheral administration of the proinflammatory cytokine interleukin (IL)-1beta can impair performance on spatial memory tasks and also elevate circulating concentration of corticosterone.	Corticosterone	185-199	interleukin 1 beta	Rattus norvegicus	69-91
14699427-3	2004	The probable involvement of corticosterone in IL-1beta-induced memory impairment was indicated by elevated corticosterone levels after IL-1beta administration.	Corticosterone	28-42	interleukin 1 beta	Rattus norvegicus	46-54
14699427-3	2004	The probable involvement of corticosterone in IL-1beta-induced memory impairment was indicated by elevated corticosterone levels after IL-1beta administration.	Corticosterone	28-42	interleukin 1 beta	Rattus norvegicus	135-143
14699427-3	2004	The probable involvement of corticosterone in IL-1beta-induced memory impairment was indicated by elevated corticosterone levels after IL-1beta administration.	Corticosterone	107-121	interleukin 1 beta	Rattus norvegicus	46-54
14699427-8	2004	Collectively, these data demonstrate that IL-1beta can impair memory function by elevating the concentration of corticosterone and that prior consumption of 1% ethyl-EPA can block both the neuroendocrine and cognitive effects of IL-1beta.	Corticosterone	112-126	interleukin 1 beta	Rattus norvegicus	42-50
14736736-10	2004	Removal of the adrenal gland significantly increased the levels of Ucn II mRNA in the skin, and the levels were reduced back to normal levels after corticosterone replacement.	Corticosterone	148-162	urocortin 2	Mus musculus	67-73
15089969-6	2004	The diurnal variation of corticosterone and the response of corticosterone to corticotropin-releasing factor were not significantly different between genotypes.	Corticosterone	60-74	corticotropin releasing hormone	Mus musculus	78-108
15048933-0	2004	Insulin-like growth factor 1 prevents neuronal cell death induced by corticosterone through activation of the PI3k/Akt pathway.	Corticosterone	69-83	insulin like growth factor 1	Homo sapiens	0-28
15048933-0	2004	Insulin-like growth factor 1 prevents neuronal cell death induced by corticosterone through activation of the PI3k/Akt pathway.	Corticosterone	69-83	AKT serine/threonine kinase 1	Homo sapiens	115-118
15048933-1	2004	Corticosterone (CORT) is well known to induce neuronal damage in various brain regions including the hippocampus, but the precise mechanism(s) of action underlying these effects has yet to be fully established.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
15001711-1	2004	Chronic restraint stress, psychosocial stress, as well as systemic or oral administration of the stress-hormone corticosterone induces a morphological reorganization in the rat hippocampus, in which adrenal steroids and excitatory amino acids mediate a reversible remodeling of apical dendrites on CA3 pyramidal cell neurons of the hippocampus.	Corticosterone	112-126	carbonic anhydrase 3	Rattus norvegicus	298-301
14711893-2	2004	In neonatal rats, the appearance of the apical sodium-dependent bile acid transporter (ASBT) at 17 d of age coincides with increases in serum corticosterone and thyroxine.	Corticosterone	142-156	solute carrier family 10 member 2	Rattus norvegicus	40-85
14711893-2	2004	In neonatal rats, the appearance of the apical sodium-dependent bile acid transporter (ASBT) at 17 d of age coincides with increases in serum corticosterone and thyroxine.	Corticosterone	142-156	solute carrier family 10 member 2	Rattus norvegicus	87-91
14711894-5	2004	injection of ACTH for 7 consecutive days (postnatal days 3-9) elevated serum corticosterone levels 20-fold measured on postnatal day 10, indicating systemic absorption and circulation of the ACTH.	Corticosterone	77-91	proopiomelanocortin	Homo sapiens	13-17
14711894-5	2004	injection of ACTH for 7 consecutive days (postnatal days 3-9) elevated serum corticosterone levels 20-fold measured on postnatal day 10, indicating systemic absorption and circulation of the ACTH.	Corticosterone	77-91	proopiomelanocortin	Homo sapiens	191-195
14718179-12	2004	However, GFAP was elevated above control levels in the cerebral cortex of rats by all treatments (corticosterone, chlorpyrifos, TOTP).	Corticosterone	98-112	glial fibrillary acidic protein	Rattus norvegicus	9-13
15124712-11	2004	After light-onset kindling, the circulating corticosterone concentrations increased and were blocked by ICV administration of the CRH receptor antagonist, astressin or alpha-hCRH.	Corticosterone	44-58	corticotropin releasing hormone	Rattus norvegicus	130-133
15129783-0	2004	Corticosterone facilitates retention of contextually conditioned fear and increases CRH mRNA expression in the amygdala.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	84-87
15014116-0	2004	Stress enables synaptic depression in CA1 synapses by acute and chronic morphine: possible mechanisms for corticosterone on opiate addiction.	Corticosterone	106-120	carbonic anhydrase 1	Homo sapiens	38-41
15129783-2	2004	This was tested by administering repeated corticosterone (CORT) within a contextual fear conditioning paradigm.	Corticosterone	42-56	cortistatin	Rattus norvegicus	58-62
14630718-1	2004	We reported that corticosterone (CORT) induces GH cell differentiation in chicken embryonic pituitary cells in culture and in living embryos.	Corticosterone	17-31	CORT	Gallus gallus	33-37
14657254-5	2004	The maximum corticosterone production induced by dibutyryl cAMP, and lipoproteins was approximately 75-85% lower in adrenal cells from HSL-/- mice compared with control.	Corticosterone	12-26	lipase, hormone sensitive	Mus musculus	135-138
14657254-7	2004	Dibutyryl cAMP-stimulated conversion of high-density lipoprotein cholesteryl esters into corticosterone was reduced 97% in HSL-/- mice.	Corticosterone	89-103	lipase, hormone sensitive	Mus musculus	123-126
15487014-15	2004	CCK-ASODN significantly increased anxiety-like behavior and impaired retention performance in the Morris water maze, compared to both control groups, accompanied by increased plasma corticosterone and plasma ACTH concentrations.	Corticosterone	182-196	cholecystokinin	Rattus norvegicus	0-3
15049859-9	2004	Semi-quantitative reverse transcription-polymerase chain reaction analyses showed that CRF and NPY mRNA fluctuated with food intake in the brain region containing the mid-posterior hypothalamus, pretectum, and optic tectum: CRF mRNA decreased 6 h after a meal and remained low through 31 days of food deprivation; NPY mRNA content also decreased 6 h after a meal, but increased to prefeeding levels by 24 h. Plasma corticosterone concentration increased 6 h after a meal, returned to prefeeding levels by 24 h, and did not change with prolonged food deprivation.	Corticosterone	415-429	neuropeptide Y S homeolog	Xenopus laevis	95-98
15094794-4	2004	In the present study changes in plasma cortisol and corticosterone concentrations in response to exogenous OT (in vivo experiment) and a direct influence of OT on adrenocortical steroidogenesis (in vitro experiment) were determined in luteal- and follicular-phase gilts.	Corticosterone	52-66	oxytocin/neurophysin I prepropeptide	Sus scrofa	107-109
15094794-5	2004	In the luteal-phase gilts (n=5), OT injections increased both cortisol (p&lt;0.01) and corticosterone (p&lt;0.05) plasma concentrations, but in the follicular-phase gilts (n=5) only the concentration of cortisol (p&lt;0.05) was elevated in response to the treatment.	Corticosterone	87-101	oxytocin/neurophysin I prepropeptide	Sus scrofa	33-35
15094794-6	2004	Areas under the cortisol and corticosterone curves calculated for 30 min period after the OT injection were statistically higher (p&lt;0.05) during the luteal than the follicular phase.	Corticosterone	29-43	oxytocin/neurophysin I prepropeptide	Sus scrofa	90-92
14985439-0	2004	Inducible cAMP early repressor regulates corticosterone suppression after tricyclic antidepressant treatment.	Corticosterone	41-55	cAMP responsive element modulator	Mus musculus	0-30
14985439-7	2004	However, the ability of DMI to suppress an acute corticosterone response after swim stress is compromised in ICER-deficient mice, suggesting that increased hypothalamic ICER mRNA after DMI treatment may be required for suppression of corticosterone release.	Corticosterone	234-248	cAMP responsive element modulator	Mus musculus	109-113
14985439-8	2004	To investigate the mechanism underlying this response, we measured corticotropin releasing factor (CRF), an upstream modulator of corticosterone release.	Corticosterone	130-144	corticotropin releasing hormone	Mus musculus	67-97
14985439-11	2004	These data indicate that ICER is required for DMI to reduce stress-induced corticosterone release through regulation of hypothalamic CRF expression, revealing a novel role for ICER in antidepressant regulation of the hypothalamic-pituitary adrenal axis.	Corticosterone	75-89	cAMP responsive element modulator	Mus musculus	25-29
14969734-6	2004	Moreover, BDNF(+/-) mice exhibited normal corticosterone and adrenocorticotropic hormone (ACTH) serum levels under baseline conditions and following immobilization stress.	Corticosterone	42-56	brain derived neurotrophic factor	Mus musculus	10-14
12965871-3	2004	Rats bearing a corticosterone pellet delivering corticosterone at concentrations in the range of chronic stress-induced levels presented a lower amount of functional muscle mitochondria with a decrease in cytochrome c oxidase and citrate synthase activities and a depletion of mitochondrial DNA.	Corticosterone	15-29	citrate synthase	Rattus norvegicus	230-246
12965871-3	2004	Rats bearing a corticosterone pellet delivering corticosterone at concentrations in the range of chronic stress-induced levels presented a lower amount of functional muscle mitochondria with a decrease in cytochrome c oxidase and citrate synthase activities and a depletion of mitochondrial DNA.	Corticosterone	48-62	citrate synthase	Rattus norvegicus	230-246
14563696-7	2004	Corticosterone-dependent mechanisms regulate CRH hnRNA levels at the nadir and peak as well as the onset of nocturnal crh gene transcription.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	45-48
14563696-9	2004	This study shows, first, CRH synthesis in intact animals is maintained by a nocturnal episode of crh gene transcription, parameters of which are modulated by corticosterone-dependent mechanisms; second, circulating corticosterone is sufficient to completely inhibit a daily rhythm of avp gene transcription present in adrenalectomized rats; third, the neural systems that activate crh gene transcription can be uncoupled from those driving ACTH release.	Corticosterone	158-172	corticotropin releasing hormone	Rattus norvegicus	25-28
14563696-9	2004	This study shows, first, CRH synthesis in intact animals is maintained by a nocturnal episode of crh gene transcription, parameters of which are modulated by corticosterone-dependent mechanisms; second, circulating corticosterone is sufficient to completely inhibit a daily rhythm of avp gene transcription present in adrenalectomized rats; third, the neural systems that activate crh gene transcription can be uncoupled from those driving ACTH release.	Corticosterone	158-172	corticotropin releasing hormone	Rattus norvegicus	97-100
14563696-9	2004	This study shows, first, CRH synthesis in intact animals is maintained by a nocturnal episode of crh gene transcription, parameters of which are modulated by corticosterone-dependent mechanisms; second, circulating corticosterone is sufficient to completely inhibit a daily rhythm of avp gene transcription present in adrenalectomized rats; third, the neural systems that activate crh gene transcription can be uncoupled from those driving ACTH release.	Corticosterone	215-229	corticotropin releasing hormone	Rattus norvegicus	25-28
14563696-9	2004	This study shows, first, CRH synthesis in intact animals is maintained by a nocturnal episode of crh gene transcription, parameters of which are modulated by corticosterone-dependent mechanisms; second, circulating corticosterone is sufficient to completely inhibit a daily rhythm of avp gene transcription present in adrenalectomized rats; third, the neural systems that activate crh gene transcription can be uncoupled from those driving ACTH release.	Corticosterone	215-229	corticotropin releasing hormone	Rattus norvegicus	97-100
14563696-9	2004	This study shows, first, CRH synthesis in intact animals is maintained by a nocturnal episode of crh gene transcription, parameters of which are modulated by corticosterone-dependent mechanisms; second, circulating corticosterone is sufficient to completely inhibit a daily rhythm of avp gene transcription present in adrenalectomized rats; third, the neural systems that activate crh gene transcription can be uncoupled from those driving ACTH release.	Corticosterone	215-229	corticotropin releasing hormone	Rattus norvegicus	381-384
14766007-0	2004	Expressions of hepatic genes, especially IGF-binding protein-1, correlating with serum corticosterone in microarray analysis.	Corticosterone	87-101	insulin-like growth factor binding protein 1	Mus musculus	41-62
14766007-4	2004	Five of these ratios correlated significantly with serum corticosterone ratio, including tyrosine aminotransferase, stress-induced protein, pleiotropic regulator 1 and insulin-like growth factor-binding protein-1; the latter has a potential role in cancer development.	Corticosterone	57-71	transformation related protein 53 inducible nuclear protein 1	Mus musculus	116-212
15013364-14	2004	mRNA for these inflammatory mediators was induced 6 h after the corticosterone pretreatment, and was associated with activation of nuclear factor-kappaB in the presence of activated glucocorticoid receptor.	Corticosterone	64-78	nuclear receptor subfamily 3, group C, member 1	Mus musculus	182-205
14687700-7	2004	Corticosterone, used as an index of CRH in the hypothalamus, was reduced by CRH antisense oligodeoxynucleotides during the same time that spontaneous wakefulness was reduced, suggesting CRH peptide modulation as the mediator of this response.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	36-39
14687700-7	2004	Corticosterone, used as an index of CRH in the hypothalamus, was reduced by CRH antisense oligodeoxynucleotides during the same time that spontaneous wakefulness was reduced, suggesting CRH peptide modulation as the mediator of this response.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	76-79
14687700-7	2004	Corticosterone, used as an index of CRH in the hypothalamus, was reduced by CRH antisense oligodeoxynucleotides during the same time that spontaneous wakefulness was reduced, suggesting CRH peptide modulation as the mediator of this response.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	76-79
15062560-4	2004	Hsp90 inhibitors; geldanamycin (GA) and radicicol (Rad), significantly accelerated nuclear export of GR after withdrawal of ligands including dexamethasone, corticosterone and RU486.	Corticosterone	157-171	heat shock protein 90 alpha family class A member 1	Homo sapiens	0-5
15062560-4	2004	Hsp90 inhibitors; geldanamycin (GA) and radicicol (Rad), significantly accelerated nuclear export of GR after withdrawal of ligands including dexamethasone, corticosterone and RU486.	Corticosterone	157-171	nuclear receptor subfamily 3 group C member 1	Homo sapiens	101-103
15062560-7	2004	Only nuclear-targeted Hsp90 prolonged basal nuclear retention of GR after withdrawal of dexamethasone and corticosterone.	Corticosterone	106-120	heat shock protein 90 alpha family class A member 1	Homo sapiens	22-27
14684257-0	2004	Increased corticosterone secretion and early-onset of cognitive decline in female apolipoprotein E-knockout mice.	Corticosterone	10-24	apolipoprotein E	Mus musculus	82-98
14684257-10	2004	Thus, although disruption of the apoE gene affects the regularity of the estrous cycle in young mice, it is the enhanced corticosterone secretion, which parallels the cognitive decline in the aging female apoE0/0 mice.	Corticosterone	121-135	apolipoprotein E	Mus musculus	33-37
14741409-3	2004	The effects of adrenalectomy in the CA2 region were partially reversed with corticosterone.	Corticosterone	76-90	carbonic anhydrase 2	Rattus norvegicus	36-39
13129852-7	2004	Supplementation with corticosterone (20 mg.kg-1.day-1) or GR-specific dexamethasone (1 mg.kg-1.day-1) during low endogenous corticosterone suppressed renal COX-2 mRNA and protein and led to a restricted distribution of COX-2 immunolabeling.	Corticosterone	21-35	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	156-161
13129852-7	2004	Supplementation with corticosterone (20 mg.kg-1.day-1) or GR-specific dexamethasone (1 mg.kg-1.day-1) during low endogenous corticosterone suppressed renal COX-2 mRNA and protein and led to a restricted distribution of COX-2 immunolabeling.	Corticosterone	21-35	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	219-224
13129852-12	2004	Thus low plasma concentrations of corticosterone allowed for cortical and medullary COX-2 induction during postnatal kidney development.	Corticosterone	34-48	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	84-89
15128271-8	2004	This testosterone-dependent decrease in pituitary transcortin was associated, in vitro, with an enhanced nuclear uptake of corticosterone.	Corticosterone	123-137	serpin family A member 6	Rattus norvegicus	50-61
14512435-9	2004	Our results suggest that increased central proinflammatory cytokine expression can compensate for the impaired HPA axis function and activates inflammatory ACTH and corticosterone responses in mice-deficient in both CRH and LIF.	Corticosterone	165-179	corticotropin releasing hormone	Mus musculus	216-219
14512435-9	2004	Our results suggest that increased central proinflammatory cytokine expression can compensate for the impaired HPA axis function and activates inflammatory ACTH and corticosterone responses in mice-deficient in both CRH and LIF.	Corticosterone	165-179	leukemia inhibitory factor	Mus musculus	224-227
14525913-5	2004	Fat pad weight as well as plasma insulin, leptin, and corticosterone levels were strongly increased in NPY-treated mice.	Corticosterone	54-68	neuropeptide Y	Mus musculus	103-106
15487014-17	2004	Lower levels of plasma corticosterone and ACTH in CCK-ASODN+CCK2R antagonist-treated rats accompanied the reduced anxiety-like behavior.	Corticosterone	23-37	cholecystokinin	Rattus norvegicus	50-53
15487014-17	2004	Lower levels of plasma corticosterone and ACTH in CCK-ASODN+CCK2R antagonist-treated rats accompanied the reduced anxiety-like behavior.	Corticosterone	23-37	cholecystokinin B receptor	Rattus norvegicus	60-65
15541902-9	2004	Since the corticosterone response could be blocked by the CRH antagonist, it is likely to be mediated through the activation of the CRH neurons.	Corticosterone	10-24	corticotropin releasing hormone	Rattus norvegicus	58-61
15017115-10	2004	CONCLUSION: These results reveal that glucose able to induce hypertension and provide evidence that glucose inhibits the transcriptions of both 11beta-HSD2 and CYP 11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Corticosterone	225-239	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	144-155
15017115-10	2004	CONCLUSION: These results reveal that glucose able to induce hypertension and provide evidence that glucose inhibits the transcriptions of both 11beta-HSD2 and CYP 11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Corticosterone	225-239	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	160-168
14654985-5	2004	Leptin(1-147) enhanced plasma concentration of both aldosterone and corticosterone.	Corticosterone	68-82	leptin	Rattus norvegicus	0-6
14709143-2	2004	We reported previously that corticosterone (CORT) could induce somatotroph differentiation in vitro and in vivo and that thyroid hormones could act in combination with CORT to further augment the abundance of somatotrophs in vitro.	Corticosterone	28-42	CORT	Gallus gallus	44-48
15791835-0	2004	Experimental study of effect of corticosterone on primary cultured hippocampal neurons and their Ca2+/CaMKII expression.	Corticosterone	32-46	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	102-108
12904339-3	2004	In general, CORT, or the analog dexamethasone (DEX), increased channel activity in inside-out bovine patches, an effect not blocked by the glucocorticoid receptor (GR) antagonist RU38486.	Corticosterone	12-16	nuclear receptor subfamily 3 group C member 1	Bos taurus	164-166
15692218-2	2004	Subordinate rats have elevated plasma corticosterone (CORT) concentration and impaired activity of the hypothalamic-pituitary-adrenal (HPA) axis compared to dominant cagemates.	Corticosterone	38-52	cortistatin	Rattus norvegicus	54-58
14532912-0	2004	Nociceptin/orphanin FQ increases anxiety-related behavior and circulating levels of corticosterone during neophobic tests of anxiety.	Corticosterone	84-98	prepronociceptin	Rattus norvegicus	0-10
14532912-0	2004	Nociceptin/orphanin FQ increases anxiety-related behavior and circulating levels of corticosterone during neophobic tests of anxiety.	Corticosterone	84-98	prepronociceptin	Rattus norvegicus	11-22
14532912-1	2004	Intracranial administration of nociceptin/orphanin FQ (N/OFQ) increases circulating concentrations of adrenocorticotrophic hormone and corticosterone in unstressed rats, and elevates the responsiveness of these hormones during mild stress.	Corticosterone	135-149	prepronociceptin	Rattus norvegicus	31-41
14532912-1	2004	Intracranial administration of nociceptin/orphanin FQ (N/OFQ) increases circulating concentrations of adrenocorticotrophic hormone and corticosterone in unstressed rats, and elevates the responsiveness of these hormones during mild stress.	Corticosterone	135-149	prepronociceptin	Rattus norvegicus	42-53
15218320-9	2004	The increase in serum corticosterone levels induced by LPS was attenuated by alpha-MSH.	Corticosterone	22-36	proopiomelanocortin	Rattus norvegicus	77-86
15249730-0	2004	Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-alpha, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor-alpha p55 receptor gene.	Corticosterone	0-14	tumor necrosis factor	Mus musculus	81-108
15249730-0	2004	Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-alpha, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor-alpha p55 receptor gene.	Corticosterone	0-14	tumor necrosis factor	Mus musculus	164-191
15249730-0	2004	Corticosterone changes in response to stressors, acute and protracted actions of tumor necrosis factor-alpha, and lipopolysaccharide treatments in mice lacking the tumor necrosis factor-alpha p55 receptor gene.	Corticosterone	0-14	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	192-195
15249730-2	2004	OBJECTIVES: As many of the central consequences of TNF-alpha are mediated by its p55 receptor, the present investigation determined the role of this receptor on the plasma corticosterone increase associated with the acute TNF-alpha treatment and the sensitized response evident upon reexposure to the cytokine.	Corticosterone	172-186	tumor necrosis factor	Mus musculus	51-60
15249730-2	2004	OBJECTIVES: As many of the central consequences of TNF-alpha are mediated by its p55 receptor, the present investigation determined the role of this receptor on the plasma corticosterone increase associated with the acute TNF-alpha treatment and the sensitized response evident upon reexposure to the cytokine.	Corticosterone	172-186	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	81-84
15249730-2	2004	OBJECTIVES: As many of the central consequences of TNF-alpha are mediated by its p55 receptor, the present investigation determined the role of this receptor on the plasma corticosterone increase associated with the acute TNF-alpha treatment and the sensitized response evident upon reexposure to the cytokine.	Corticosterone	172-186	tumor necrosis factor	Mus musculus	222-231
15249730-3	2004	Moreover, the role of p55 in the provocation of corticosterone release engendered by lipopolysaccharide (LPS) and psychogenic stressors (noise or restraint) was also determined.	Corticosterone	48-62	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	22-25
15249730-5	2004	RESULTS: Mice deficient for p55 displayed a greatly attenuated plasma corticosterone response to TNF-alpha irrespective of whether they had been previously exposed to the cytokine.	Corticosterone	70-84	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	28-31
15249730-5	2004	RESULTS: Mice deficient for p55 displayed a greatly attenuated plasma corticosterone response to TNF-alpha irrespective of whether they had been previously exposed to the cytokine.	Corticosterone	70-84	tumor necrosis factor	Mus musculus	97-106
15249730-7	2004	CONCLUSIONS: It appears that although p55 modulates the corticosterone-inducing effects of TNF-alpha, the receptor does not play a critical role in the activation of the HPA axis by "traditional" psychogenic stressors (noise, restraint) or systemic endotoxin challenge.	Corticosterone	56-70	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	38-41
15249730-7	2004	CONCLUSIONS: It appears that although p55 modulates the corticosterone-inducing effects of TNF-alpha, the receptor does not play a critical role in the activation of the HPA axis by "traditional" psychogenic stressors (noise, restraint) or systemic endotoxin challenge.	Corticosterone	56-70	tumor necrosis factor	Mus musculus	91-100
15316242-3	2004	Little is known about regulation of their production, and therefore the purpose of the present work was to describe the relationship between circulating corticosterone and the mRNA expression of proopiomelanocortin (POMC), IL-1 beta and IL-6 in the AP during a 24-hour cycle in normal rats and rats with acute adjuvant arthritis (AA).	Corticosterone	153-167	proopiomelanocortin	Rattus norvegicus	195-214
15316242-3	2004	Little is known about regulation of their production, and therefore the purpose of the present work was to describe the relationship between circulating corticosterone and the mRNA expression of proopiomelanocortin (POMC), IL-1 beta and IL-6 in the AP during a 24-hour cycle in normal rats and rats with acute adjuvant arthritis (AA).	Corticosterone	153-167	proopiomelanocortin	Rattus norvegicus	216-220
15316242-3	2004	Little is known about regulation of their production, and therefore the purpose of the present work was to describe the relationship between circulating corticosterone and the mRNA expression of proopiomelanocortin (POMC), IL-1 beta and IL-6 in the AP during a 24-hour cycle in normal rats and rats with acute adjuvant arthritis (AA).	Corticosterone	153-167	interleukin 1 beta	Rattus norvegicus	223-232
15316242-3	2004	Little is known about regulation of their production, and therefore the purpose of the present work was to describe the relationship between circulating corticosterone and the mRNA expression of proopiomelanocortin (POMC), IL-1 beta and IL-6 in the AP during a 24-hour cycle in normal rats and rats with acute adjuvant arthritis (AA).	Corticosterone	153-167	interleukin 6	Rattus norvegicus	237-241
15316242-8	2004	POMC mRNA in AP also showed a circadian rhythm (p &lt; 0.05) which was inversely related to corticosterone levels.	Corticosterone	92-106	proopiomelanocortin	Rattus norvegicus	0-4
15316242-14	2004	CONCLUSION: These results suggest a regulatory relationship between circulating corticosterone and the expression of POMC, IL-1 beta and IL-6 in AP of normal rats.	Corticosterone	80-94	proopiomelanocortin	Rattus norvegicus	117-121
15316242-14	2004	CONCLUSION: These results suggest a regulatory relationship between circulating corticosterone and the expression of POMC, IL-1 beta and IL-6 in AP of normal rats.	Corticosterone	80-94	interleukin 1 beta	Rattus norvegicus	123-132
15316242-14	2004	CONCLUSION: These results suggest a regulatory relationship between circulating corticosterone and the expression of POMC, IL-1 beta and IL-6 in AP of normal rats.	Corticosterone	80-94	interleukin 6	Rattus norvegicus	137-141
15316243-1	2004	Corticosterone (CORT) and norepinephrine (NE), two effector molecules of the hypothalamic-pituitary-adrenal (HPA) and the sympathetic-lymphoid (SL) axes, respectively, differentially influence murine host resistance to Listeria monocytogenes (LM).	Corticosterone	0-14	cortistatin	Mus musculus	16-20
14512285-4	2004	In one approach, we implanted pellets of corticosterone (Cort) or sham pellets onto the DHB over the NTS.	Corticosterone	41-55	cortistatin	Rattus norvegicus	57-61
15541902-9	2004	Since the corticosterone response could be blocked by the CRH antagonist, it is likely to be mediated through the activation of the CRH neurons.	Corticosterone	10-24	corticotropin releasing hormone	Rattus norvegicus	132-135
15627803-2	2004	These changes are manifest as an elevation in basal corticosterone (CORT) levels, a sensitization of adrenocorticotropin hormone (ACTH) and CORT responses to subsequent challenge, and a failure of dexamethasone to suppress both the ACTH and CORT responses to a subsequent challenge.	Corticosterone	52-66	cortistatin	Homo sapiens	68-72
15026138-4	2004	Since BDNF expression is suppressed by corticosterone (CORT), circulating CORT levels were also monitored.	Corticosterone	39-53	brain derived neurotrophic factor	Homo sapiens	6-10
14980392-0	2004	Chronic corticosterone affects brain weight, and mitochondrial, but not glial volume fraction in hippocampal area CA3.	Corticosterone	8-22	carbonic anhydrase 3	Rattus norvegicus	114-117
14980392-1	2004	Corticosterone (CORT), the predominant glucocorticoid in rodents, is known to damage hippocampal area CA3.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
15207367-8	2004	Our results indicate that chronic stress and chronic corticosterone administration have differential effects on the expression of PSA-NCAM and DCX.	Corticosterone	53-67	aminopeptidase puromycin sensitive	Rattus norvegicus	130-133
14980392-1	2004	Corticosterone (CORT), the predominant glucocorticoid in rodents, is known to damage hippocampal area CA3.	Corticosterone	0-14	carbonic anhydrase 3	Rattus norvegicus	102-105
15099681-7	2004	Pre-treatment of cultures with corticosterone (0.1-1 microM) markedly exacerbated NMDA-induced CA1 and dentate gyrus region damage.	Corticosterone	31-45	carbonic anhydrase 1	Homo sapiens	95-98
15099681-10	2004	Co-administration of cultures to (-)-nicotine (1-10 microM) with 100 nM corticosterone prevented corticosterone"s exacerbation of subsequent CA1 insult.	Corticosterone	72-86	carbonic anhydrase 1	Homo sapiens	141-144
15099681-10	2004	Co-administration of cultures to (-)-nicotine (1-10 microM) with 100 nM corticosterone prevented corticosterone"s exacerbation of subsequent CA1 insult.	Corticosterone	97-111	carbonic anhydrase 1	Homo sapiens	141-144
15283957-0	2004	The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses.	Corticosterone	85-99	interleukin 1 beta	Rattus norvegicus	12-20
15003366-7	2004	The in vivo administration of beacon[47-73] (3.5 nmol/100 body weight) elicited within 60 min a marked decrease in the plasma concentration of ACTH, aldosterone and corticosterone, and a moderate lowering of the blood levels of testosterone and estradiol.	Corticosterone	165-179	ubiquitin-like 5	Rattus norvegicus	30-36
14993068-3	2003	Ndrg2 mRNA was also upregulated by corticosterone in cerebral cortex and heart.	Corticosterone	35-49	NDRG family member 2	Rattus norvegicus	0-5
14993068-8	2003	In one of these regions, the subgranular zone of the dentate gyrus, Ndrg2 expression was decreased after adrenalectomy, and was restored to sham-operated levels by corticosterone, indicating that it is under positive regulation by glucocorticoids in vivo.	Corticosterone	164-178	NDRG family member 2	Rattus norvegicus	68-73
15467350-8	2004	LPS application decreased serum concentrations of T3 and TSH (both after 2 h), testosterone (after 2 and 4 h), FSH after 4 h and PRL after 4 h. VIP administration decreased the serum IL-10 concentration after 4 h and T3 concentration after 2 h and increased serum concentrations of FSH and corticosterone after 4 h. VIP administrated simultaneously with LPS decreased the LPS-induced increase in IL-6 and corticosterone concentrations (consecutively after 2 and 4 h).	Corticosterone	290-304	vasoactive intestinal peptide	Rattus norvegicus	144-147
15467350-8	2004	LPS application decreased serum concentrations of T3 and TSH (both after 2 h), testosterone (after 2 and 4 h), FSH after 4 h and PRL after 4 h. VIP administration decreased the serum IL-10 concentration after 4 h and T3 concentration after 2 h and increased serum concentrations of FSH and corticosterone after 4 h. VIP administrated simultaneously with LPS decreased the LPS-induced increase in IL-6 and corticosterone concentrations (consecutively after 2 and 4 h).	Corticosterone	405-419	vasoactive intestinal peptide	Rattus norvegicus	144-147
14741228-10	2004	Corticosterone was elevated by food deprivation during transitional periods in CD-1 mice and during both transition and dark phases in C57 mice.	Corticosterone	0-14	CD1 antigen complex	Mus musculus	79-83
14741228-11	2004	Corticosterone response in restrained CD-1 mice was increased during the dark phase.	Corticosterone	0-14	CD1 antigen complex	Mus musculus	38-42
14719033-10	2003	High CK activity and hyperglycemia maintain the energy demands of metabolism, and elevated corticosterone desensitizes the insulin receptor in AS.	Corticosterone	91-105	insulin receptor	Rattus norvegicus	123-139
15207367-8	2004	Our results indicate that chronic stress and chronic corticosterone administration have differential effects on the expression of PSA-NCAM and DCX.	Corticosterone	53-67	neural cell adhesion molecule 1	Rattus norvegicus	134-138
15207367-8	2004	Our results indicate that chronic stress and chronic corticosterone administration have differential effects on the expression of PSA-NCAM and DCX.	Corticosterone	53-67	doublecortin	Rattus norvegicus	143-146
14656306-2	2003	The stress hormone corticosterone exerts a complex modulation on neurogenesis and PSA-NCAM, and previous studies have shown that mature granule cells require corticosterone for their survival.	Corticosterone	19-33	neural cell adhesion molecule 1	Rattus norvegicus	86-90
14656306-2	2003	The stress hormone corticosterone exerts a complex modulation on neurogenesis and PSA-NCAM, and previous studies have shown that mature granule cells require corticosterone for their survival.	Corticosterone	158-172	neural cell adhesion molecule 1	Rattus norvegicus	86-90
14656306-6	2003	It is concluded that stimulation of the mineralocorticoid receptor is sufficient to mediate the effects of corticosterone on neurogenesis and to protect mature cells from cell death whereas stimulation of the glucocorticoid receptor is necessary to modulate PSA-NCAM expression.	Corticosterone	107-121	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	40-66
14612964-7	2003	CCK1-RA, although being per se ineffective, in the presence of CCK raised plasma levels of aldosterone and corticosterone; conversely, CCK2-RA, either alone or in the presence of agonists, lowered the blood concentrations of the two hormones.	Corticosterone	107-121	cholecystokinin	Rattus norvegicus	0-3
12970157-6	2003	The homozygous POMC-null mouse lacks central as well as peripheral MSH signaling; in addition, it lacks adrenal glands and thus is devoid of corticosterone and epinephrine.	Corticosterone	141-155	pro-opiomelanocortin-alpha	Mus musculus	15-19
14636179-7	2003	By contrast, in the anterior lobe of the pituitary, a substantial increase in POMC mRNA and adrenocorticotropin hormone concentrations was observed, and plasma corticosterone concentration was significantly higher in A2AR-/- mice, revealing hyperactivity of their pituitary-adrenocortical axis.	Corticosterone	160-174	adenosine A2a receptor	Mus musculus	217-221
14644035-1	2003	Tumor necrosis factor-alpha (TNF-alpha) provokes a time-dependent sensitization of brain monoamine activity, plasma corticosterone activity and sickness behavior, the latter being reminiscent of septic or anaphylactic shock.	Corticosterone	116-130	tumor necrosis factor	Homo sapiens	0-27
14644035-1	2003	Tumor necrosis factor-alpha (TNF-alpha) provokes a time-dependent sensitization of brain monoamine activity, plasma corticosterone activity and sickness behavior, the latter being reminiscent of septic or anaphylactic shock.	Corticosterone	116-130	tumor necrosis factor	Homo sapiens	29-38
14644035-2	2003	In this investigation, bovine serum albumin (BSA) elicited similar corticosterone and sickness profiles, whereas the monoamine changes were not observed.	Corticosterone	67-81	albumin	Homo sapiens	30-43
14664705-6	2003	The expression of GHRH receptor was markedly enhanced by glucocorticoid pretreatment and, in the presence of corticosterone and 3-isobutyl-1-methylxanthine, GHRH (at or above 100 pM) stimulated GH gene 5"-promoter activity in a dose-dependent manner.	Corticosterone	109-123	growth hormone releasing hormone receptor	Rattus norvegicus	18-31
14698207-4	2003	Native murine leptin (1-147) enhanced aldosterone and corticosterone secretion from dispersed ZG and ZF/R cells, and similar effects were elicited by murine leptin fragment 116-130, and human leptin fragments 138-167, 150-167 and [Tyr] 26-39.	Corticosterone	54-68	leptin	Mus musculus	14-20
14563692-4	2003	Serum levels of these hormones, together with adrenal corticosterone, increase dose dependently with recombinant C3a and C3adesArg administration in vivo.	Corticosterone	54-68	complement C3	Homo sapiens	113-116
14573385-2	2003	To examine this modulation, the effects of acute and chronic corticosterone administration on 5-HT(1A) autoreceptor function were investigated using in vitro electrophysiology in the rat dorsal raphe nucleus (DRN).	Corticosterone	61-75	5-hydroxytryptamine receptor 1A	Rattus norvegicus	94-101
14511987-1	2003	Chicken ghrelin has recently been isolated as a hormone which stimulates growth hormone and corticosterone secretion in chicken.	Corticosterone	92-106	ghrelin/obestatin prepropeptide	Gallus gallus	8-15
14573752-2	2003	Tetrabutylammonium (TBuA) and corticosterone were identified as nontransported inhibitors that bind to the substrate binding site of rOCT2.	Corticosterone	30-44	solute carrier family 22 member 2	Rattus norvegicus	133-138
14688443-6	2003	These data suggest that during dehydration, elevated plasma VP can stimulate the production of corticosterone by the adrenal, independently of ACTH.	Corticosterone	95-109	arginine vasopressin	Rattus norvegicus	60-62
14688443-7	2003	Moreover, they support the hypothesis that the decline in corticosterone after restriction-induced drinking is due, in part, to a decline in plasma VP.	Corticosterone	58-72	arginine vasopressin	Rattus norvegicus	148-150
12888779-6	2003	Abcb1ab (-/-) mice showed consistently lower plasma ACTH levels and lower evening plasma corticosterone levels.	Corticosterone	89-103	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	0-5
12960064-10	2003	ACTH was found to play a causal role in DEX-induced decrease in Ang-1/Tie2 system, because 7 d treatment with long acting 1-39 ACTH (30 IU/kg x d) increased Ang-1, Tie2 expression, and plasma corticosterone back to control levels.	Corticosterone	192-206	pro-opiomelanocortin-alpha	Mus musculus	0-4
12960064-10	2003	ACTH was found to play a causal role in DEX-induced decrease in Ang-1/Tie2 system, because 7 d treatment with long acting 1-39 ACTH (30 IU/kg x d) increased Ang-1, Tie2 expression, and plasma corticosterone back to control levels.	Corticosterone	192-206	angiopoietin 1	Mus musculus	64-69
12960064-10	2003	ACTH was found to play a causal role in DEX-induced decrease in Ang-1/Tie2 system, because 7 d treatment with long acting 1-39 ACTH (30 IU/kg x d) increased Ang-1, Tie2 expression, and plasma corticosterone back to control levels.	Corticosterone	192-206	TEK receptor tyrosine kinase	Mus musculus	70-74
12960064-10	2003	ACTH was found to play a causal role in DEX-induced decrease in Ang-1/Tie2 system, because 7 d treatment with long acting 1-39 ACTH (30 IU/kg x d) increased Ang-1, Tie2 expression, and plasma corticosterone back to control levels.	Corticosterone	192-206	pro-opiomelanocortin-alpha	Mus musculus	127-131
14688443-0	2003	Regulation of corticosterone production by vasopressin during water restriction and after drinking in rats.	Corticosterone	14-28	arginine vasopressin	Rattus norvegicus	43-54
14688443-2	2003	Studies were performed to determine if plasma VP and corticosterone are reduced in parallel after drinking and if manipulation of plasma VP affects plasma, ACTH corticotropins and corticosterone in a model of water restriction.	Corticosterone	180-194	arginine vasopressin	Rattus norvegicus	137-139
14688443-3	2003	A strong correlation between changes in plasma VP and corticosterone, but not between plasma ACTH and corticosterone, was observed after drinking induced by 6 days of water restriction.	Corticosterone	54-68	arginine vasopressin	Rattus norvegicus	47-49
14688443-4	2003	Similarly, ingestion of isotonic saline resulted in a biphasic VP response that was paralleled by adrenal and plasma corticosterone, but not by plasma ACTH.	Corticosterone	117-131	arginine vasopressin	Rattus norvegicus	63-65
14688443-5	2003	Administration of an immunoneutralizing antibody directed against VP resulted in a rapid decrease in plasma corticosterone, but not ACTH, in water-restricted rats, but not in rats receiving water ad libitum.	Corticosterone	108-122	arginine vasopressin	Rattus norvegicus	66-68
14593430-6	2003	Plasma corticosterone (CORT) response to restraint stress was significantly lower and less variable in WMI compared to WLI males.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
14969423-3	2003	After administration of interleukin-2, the corticosterone level was identical in both groups of animals, though it reached the basal level in tame rats more quickly than in rats selected for maintaining aggressive behavior.	Corticosterone	43-57	interleukin 2	Rattus norvegicus	24-37
14637235-6	2003	Reactivity to LPS and sensitivity to corticosterone (CS) of spleen cells was assessed by measuring the in vitro production of cytokines (IL-6, IFN-gamma and IL-10) in response to LPS under a range of increasing concentrations of CS.	Corticosterone	37-51	interleukin 6	Mus musculus	137-141
14637235-6	2003	Reactivity to LPS and sensitivity to corticosterone (CS) of spleen cells was assessed by measuring the in vitro production of cytokines (IL-6, IFN-gamma and IL-10) in response to LPS under a range of increasing concentrations of CS.	Corticosterone	53-55	interleukin 6	Mus musculus	137-141
14637235-6	2003	Reactivity to LPS and sensitivity to corticosterone (CS) of spleen cells was assessed by measuring the in vitro production of cytokines (IL-6, IFN-gamma and IL-10) in response to LPS under a range of increasing concentrations of CS.	Corticosterone	53-55	interferon gamma	Mus musculus	143-152
14637235-6	2003	Reactivity to LPS and sensitivity to corticosterone (CS) of spleen cells was assessed by measuring the in vitro production of cytokines (IL-6, IFN-gamma and IL-10) in response to LPS under a range of increasing concentrations of CS.	Corticosterone	53-55	interleukin 10	Mus musculus	157-162
12807698-7	2003	Corticosterone and O-methylisoprenaline (1 microM each), but not desipramine, inhibited NE uptake, a profile indicative of NE uptake by EMT, but not OCT-1.	Corticosterone	0-14	solute carrier family 22 member 3	Homo sapiens	136-139
14759076-2	2003	However, little is known about patterns of sex hormones and corticosterone (CORT) secretion throughout the estrous cycle in this strain, which is characterized by a marked CORT response to stress and variable length of cycles.	Corticosterone	60-74	cortistatin	Rattus norvegicus	76-80
14525525-3	2003	Whereas the regeneration of active glucocorticoids by 11 beta HSD1 has been implicated in the cellular mechanisms of pituitary function, ovulation and parturition, the enzymatic inactivation of cortisol and corticosterone by 11 beta HSD enzymes appears to be central to the protection of gonadal steroidogenesis, prevention of intra-uterine growth retardation, and lactation.	Corticosterone	207-221	RNA, U1 small nuclear 1	Homo sapiens	62-66
14622208-3	2003	IL-1beta treatment also increased serum corticosterone.	Corticosterone	40-54	interleukin 1 beta	Rattus norvegicus	0-8
14622208-4	2003	This increase in serum corticosterone was further enhanced in rats given both IL-1beta and footshock.	Corticosterone	23-37	interleukin 1 beta	Rattus norvegicus	78-86
14622208-5	2003	Furthermore, the glucocorticoid receptor antagonist mifepristone blocked IL-1beta-induced elevation in corticosterone and also attenuated the enhanced conditioned fear memory.	Corticosterone	103-117	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	17-40
14622208-5	2003	Furthermore, the glucocorticoid receptor antagonist mifepristone blocked IL-1beta-induced elevation in corticosterone and also attenuated the enhanced conditioned fear memory.	Corticosterone	103-117	interleukin 1 beta	Rattus norvegicus	73-81
12967720-3	2003	Central administration of GLP-1 increases plasma corticosterone levels and elicits c-fos expression in corticotropin releasing hormone (CRH) neurons of the hypothalamic paraventricular nucleus (PVN).	Corticosterone	49-63	glucagon	Rattus norvegicus	26-31
12972328-3	2003	We show that restraint stress caused a significant increase in plasma corticosterone levels in female CRH KO mice, but LPS administration induced a significant increase in plasma corticosterone levels in both female and male CRH KO mice.	Corticosterone	179-193	corticotropin releasing hormone	Mus musculus	225-228
12972328-8	2003	These data indicate: (1) that lack of CRH may decreases cardiac CRH-R2 mRNA expression in basal state, (2) that inhibitory effect of CRH deficiency on cardiac CRH-R2 mRNA expression in stress condition seems to be more closely linked to type of stressor than rise in plasma corticosterone level.	Corticosterone	274-288	corticotropin releasing hormone receptor 2	Mus musculus	159-165
12784107-8	2003	Finally in fluoxetine, corticosterone, and corticosterone plus fluoxetine groups, there was marked 5-HT1A receptor desensitization, evidenced by attenuation of the decrease in 5-HT release following systemic fluoxetine injection.	Corticosterone	23-37	5-hydroxytryptamine receptor 1A	Homo sapiens	99-114
12784107-8	2003	Finally in fluoxetine, corticosterone, and corticosterone plus fluoxetine groups, there was marked 5-HT1A receptor desensitization, evidenced by attenuation of the decrease in 5-HT release following systemic fluoxetine injection.	Corticosterone	43-57	5-hydroxytryptamine receptor 1A	Homo sapiens	99-114
14525525-2	2003	To date, two isoforms of 11 beta HSD have been cloned: 11 beta HSD1 acts predominantly as an NADP(H)-dependent reductase to generate active cortisol or corticosterone, and 11 beta HSD2 is a high affinity NAD(+)-dependent enzyme that catalyses the enzymatic inactivation of glucocorticoids.	Corticosterone	152-166	RNA, U1 small nuclear 1	Homo sapiens	63-67
14672278-0	2003	Relative and combined effects of estradiol and prolactin on corticosterone secretion in ovariectomized rats.	Corticosterone	60-74	prolactin	Rattus norvegicus	47-56
14672278-5	2003	In the morning and afternoon, EB enhanced the basal and ACTH-stimulated concentrations of plasma corticosterone (CORT) and PRL.	Corticosterone	97-111	cortistatin	Rattus norvegicus	113-117
12933655-1	2003	Our laboratory has reported that somatotroph differentiation occurs between d 14 and d 16 of chicken embryonic development and that corticosterone (CORT) can induce somatotroph differentiation at an earlier age in vitro and in vivo.	Corticosterone	132-146	CORT	Gallus gallus	148-152
14758635-0	2003	[Effect of prolactin on the level of corticosterone in the blood and synthesis of lymphocyte-activating factors by macrophages under conditions of glucocorticoid loading].	Corticosterone	37-51	prolactin	Rattus norvegicus	11-20
14758635-2	2003	It was shown that prolactin application increased the level of corticosterone in the rat blood.	Corticosterone	63-77	prolactin	Rattus norvegicus	18-27
14758635-3	2003	Administration of prolactin prior to hydrocortisone administration induced alteration in the level of corticosterone that depended on the dose of hydrocortisone.	Corticosterone	102-116	prolactin	Rattus norvegicus	18-27
12686508-5	2003	AT1 blockade increased gastric blood flow by 40-50%, prevented gastric ulcer formation by 70-80% after cold-restraint stress, reduced the increase in adrenomedullary epinephrine and tyrosine hydroxylase mRNA without preventing the stress-induced increase in adrenal corticosterone, decreased the stress-induced expression of TNF-alpha and that of the adhesion protein ICAM-1 in arterial endothelium, decreased the neutrophil infiltration in the gastric mucosa, and decreased the gastric content of PGE2.	Corticosterone	266-280	angiotensin II receptor, type 1a	Rattus norvegicus	0-3
12831826-6	2003	RESULTS: Physiological corticosterone concentrations (10(-7)M) resulted in an increase in IL-6 concentration (142%) while high doses of steroid decreased IL-6 significantly (CS 10(-6)M: 88+/-14%,p&lt;.05; CS 10(-5): 91+/-9%,p&lt;.05) after 5h.	Corticosterone	23-37	interleukin 6	Rattus norvegicus	90-94
12831826-9	2003	CONCLUSION: Myocardial IL-6 secretion is modulated by physiological concentrations of corticosterone or angiotensin II and can be induced by LPS or isoproterenol, indicating a tight regulation of this cytokine.	Corticosterone	86-100	interleukin 6	Rattus norvegicus	23-27
12865328-4	2003	Pretreatment with a sc injection of corticosterone (10 mg) almost completely restored LH pulses after TNF-alpha injection in OVX/ADX animals.	Corticosterone	36-50	tumor necrosis factor	Rattus norvegicus	102-111
12700160-2	2003	The NAD+-dependent type 2 (11betaHSD2) enzyme is an oxidase that inactivates cortisol and corticosterone, conferring extrinsic specificity of the mineralocorticoid receptor for aldosterone.	Corticosterone	90-104	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	27-37
12700160-2	2003	The NAD+-dependent type 2 (11betaHSD2) enzyme is an oxidase that inactivates cortisol and corticosterone, conferring extrinsic specificity of the mineralocorticoid receptor for aldosterone.	Corticosterone	90-104	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	146-172
12865328-6	2003	Pretreatment with corticosterone decreased the number of Fos-immunoreactive cells in the PVN and SON but not in the DMH.	Corticosterone	18-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-60
14599119-1	2003	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1) behaves predominantly as an oxoreductase converting the receptor-inactive glucocorticoids to their active forms in vivo, while the type 2 isoform (11beta-HSD2) possesses only dehydrogenase activity and inactivates cortisol in human or corticosterone in rat.	Corticosterone	292-306	RNA, U1 small nuclear 1	Homo sapiens	0-55
14599119-3	2003	Enzyme activity of 11beta-HSD1 and 2 in lung tissue homogenate were determined as NADP(+)- and NAD(+)-dependent conversion of corticosterone to 11-dehydrocorticosterone, respectively.	Corticosterone	126-140	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	19-36
12892842-3	2003	The increased StAR protein expression paralleled increases in plasma pregnenolone, progesterone and corticosterone levels.	Corticosterone	100-114	steroidogenic acute regulatory protein	Rattus norvegicus	14-18
12943291-3	2003	It has been suggested that corticosterone (CORT) response to manual restraint as a measure for stress is associated with FP behavior.	Corticosterone	27-41	CORT	Gallus gallus	43-47
12834911-4	2003	After the conflict, the beta-endorphin deficient mice had higher corticosterone levels but the peak increase in body temperature was not different from that in wild type animals.	Corticosterone	65-79	pro-opiomelanocortin-alpha	Mus musculus	24-38
12867498-2	2003	We show that glucagon-like peptide-1 (7-36) amide (GLP-1) increases levels of the stress-activated hormones ACTH and corticosterone when administered directly into the rat brain and increases levels of anxiety as measured by the elevated plus maze.	Corticosterone	117-131	glucagon	Rattus norvegicus	13-36
12867498-2	2003	We show that glucagon-like peptide-1 (7-36) amide (GLP-1) increases levels of the stress-activated hormones ACTH and corticosterone when administered directly into the rat brain and increases levels of anxiety as measured by the elevated plus maze.	Corticosterone	117-131	glucagon	Rattus norvegicus	51-56
12848900-8	2003	Conversely, corticosterone implants induced both AGRP and POMC mRNA (with a non-significant trend toward induction of NPY mRNA), accompanied by elevated insulin and leptin (with no change in food intake or body weight).	Corticosterone	12-26	agouti related neuropeptide	Mus musculus	49-53
12848900-8	2003	Conversely, corticosterone implants induced both AGRP and POMC mRNA (with a non-significant trend toward induction of NPY mRNA), accompanied by elevated insulin and leptin (with no change in food intake or body weight).	Corticosterone	12-26	pro-opiomelanocortin-alpha	Mus musculus	58-62
12848900-8	2003	Conversely, corticosterone implants induced both AGRP and POMC mRNA (with a non-significant trend toward induction of NPY mRNA), accompanied by elevated insulin and leptin (with no change in food intake or body weight).	Corticosterone	12-26	neuropeptide Y	Mus musculus	118-121
12853419-0	2003	c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region.	Corticosterone	14-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
12848900-10	2003	Specifically, elevated plasma corticosterone is necessary for the induction of NPY mRNA with fasting and diabetes; since corticosterone implants only produced a non-significant trend in NPY mRNA, it remains uncertain if a rise in corticosterone may be sufficient to induce NPY mRNA.	Corticosterone	30-44	neuropeptide Y	Mus musculus	79-82
12848900-10	2003	Specifically, elevated plasma corticosterone is necessary for the induction of NPY mRNA with fasting and diabetes; since corticosterone implants only produced a non-significant trend in NPY mRNA, it remains uncertain if a rise in corticosterone may be sufficient to induce NPY mRNA.	Corticosterone	121-135	neuropeptide Y	Mus musculus	186-189
12848900-10	2003	Specifically, elevated plasma corticosterone is necessary for the induction of NPY mRNA with fasting and diabetes; since corticosterone implants only produced a non-significant trend in NPY mRNA, it remains uncertain if a rise in corticosterone may be sufficient to induce NPY mRNA.	Corticosterone	121-135	neuropeptide Y	Mus musculus	186-189
12848900-10	2003	Specifically, elevated plasma corticosterone is necessary for the induction of NPY mRNA with fasting and diabetes; since corticosterone implants only produced a non-significant trend in NPY mRNA, it remains uncertain if a rise in corticosterone may be sufficient to induce NPY mRNA.	Corticosterone	121-135	neuropeptide Y	Mus musculus	186-189
12848900-10	2003	Specifically, elevated plasma corticosterone is necessary for the induction of NPY mRNA with fasting and diabetes; since corticosterone implants only produced a non-significant trend in NPY mRNA, it remains uncertain if a rise in corticosterone may be sufficient to induce NPY mRNA.	Corticosterone	121-135	neuropeptide Y	Mus musculus	186-189
12848900-11	2003	A rise in corticosterone is necessary to reduce hypothalamic POMC mRNA with fasting and diabetes, but not sufficient for the reduction of hypothalamic POMC mRNA.	Corticosterone	10-24	pro-opiomelanocortin-alpha	Mus musculus	61-65
12848900-12	2003	Finally, elevated plasma corticosterone is both necessary and sufficient for the induction of hypothalamic AGRP mRNA with fasting and diabetes.	Corticosterone	25-39	agouti related neuropeptide	Mus musculus	107-111
12824055-8	2003	Pre- and postpubertal ADX rats implanted with a high-dose corticosterone pellet had decreased expression of PVN NR1 mRNA.	Corticosterone	58-72	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	112-115
12871829-11	2003	Moreover, we have examined the effects of fluoxetine on GR-mediated gene transcription in the presence of cortisol and corticosterone, and on the intracellular accumulation of radioactive cortisol and corticosterone.	Corticosterone	119-133	nuclear receptor subfamily 3 group C member 1	Homo sapiens	56-58
12810555-11	2003	This may be exacerbated by impaired local regeneration of corticosterone by 11betaHSD1.	Corticosterone	58-72	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	76-86
12944516-6	2003	MTII (0.5 nmol)-induced increase in plasma corticosterone was attenuated by the selective MC4R antagonist HS014 (0.25-1.0 nmol) and nonselective CRH receptor antagonist alpha-helical-CRH9-41 (0.125-0.5 nmol) in a dose-dependent manner.	Corticosterone	43-57	melanocortin 4 receptor	Rattus norvegicus	90-94
12944516-6	2003	MTII (0.5 nmol)-induced increase in plasma corticosterone was attenuated by the selective MC4R antagonist HS014 (0.25-1.0 nmol) and nonselective CRH receptor antagonist alpha-helical-CRH9-41 (0.125-0.5 nmol) in a dose-dependent manner.	Corticosterone	43-57	corticotropin releasing hormone	Rattus norvegicus	183-186
12807724-8	2003	Dietary administration of corticosterone also reduced plasma insulin-like growth factor-1 (IGF-1) and levels of IGF-1 receptor in mammary carcinomas (P&lt;0.01).	Corticosterone	26-40	insulin-like growth factor 1	Rattus norvegicus	61-89
12807724-8	2003	Dietary administration of corticosterone also reduced plasma insulin-like growth factor-1 (IGF-1) and levels of IGF-1 receptor in mammary carcinomas (P&lt;0.01).	Corticosterone	26-40	insulin-like growth factor 1	Rattus norvegicus	91-96
12807724-8	2003	Dietary administration of corticosterone also reduced plasma insulin-like growth factor-1 (IGF-1) and levels of IGF-1 receptor in mammary carcinomas (P&lt;0.01).	Corticosterone	26-40	insulin-like growth factor 1 receptor	Rattus norvegicus	112-126
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	cyclin D1	Rattus norvegicus	10-19
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	cyclin E1	Rattus norvegicus	21-29
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	cyclin dependent kinase 2	Rattus norvegicus	31-62
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	cyclin-dependent kinase 4	Rattus norvegicus	67-72
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	194-198
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	199-202
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	cyclin-dependent kinase inhibitor 1A	Rattus norvegicus	207-211
12807724-10	2003	Levels of cyclin D1, cyclin E, cyclin-dependent kinase (CDK)-2 and CDK-4 were reduced in carcinomas from corticosterone treated rats; whereas, levels of cyclin-dependent kinase inhibitors (CKI) Kip1/p27 and Cip1/p21 were elevated.	Corticosterone	105-119	KRAS proto-oncogene, GTPase	Rattus norvegicus	212-215
12823256-2	2003	The major corticosteroids aldosterone and cortisol (corticosterone in rodents) are secreted from the adrenal cortex under the regulation of the renin-angiotensin system and the hypothalamic-pituitary-adrenal axis.	Corticosterone	52-66	renin	Homo sapiens	144-149
12853419-0	2003	c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region.	Corticosterone	14-28	neurotrophin 3	Rattus norvegicus	49-68
12853419-0	2003	c-fos reduces corticosterone-mediated effects on neurotrophic factor expression in the rat hippocampal CA1 region.	Corticosterone	14-28	carbonic anhydrase 1	Rattus norvegicus	103-106
12853419-2	2003	A time course for corticosterone (10 mg/kg, s.c.) in adrenalectomized rats revealed a peak hormone effect at the 4 hr time interval for bFGF (110-204% increase), BDNF (53-67% decrease), GR (53-64% decrease), and MR (34-56% decrease) mRNA levels in all hippocampal subregions using in situ hybridization.	Corticosterone	18-32	brain-derived neurotrophic factor	Rattus norvegicus	162-166
12853419-4	2003	Furthermore, it was evaluated whether corticosterone regulation of these genes depends on interactions with the transcription factor complex activator protein-1.	Corticosterone	38-52	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	141-160
12787047-3	2003	Intracerebroventricular injection of orexin-A (0.5 micro g, 140 pmol) significantly increased plasma adrenocorticotropic hormone and corticosterone concentration within 10 min in virgin female Sprague-Dawley rats, but had no effect in day 21 pregnant rats.	Corticosterone	133-147	hypocretin neuropeptide precursor	Rattus norvegicus	37-45
12864970-3	2003	Baseline corticosterone concentrations were higher in nNOS(-/-) than WT mice.	Corticosterone	9-23	nitric oxide synthase 1, neuronal	Mus musculus	54-58
12792820-5	2003	In normoglycemic rats, glucagon increased basal aldosterone and corticosterone secretion from ZG and ZF/R cells, GLP-2 raised both basal and ACTH-stimulated aldosterone secretion and ACTH-stimulated corticosterone output, and EX4 increased basal corticosterone secretion.	Corticosterone	199-213	mast cell protease 10	Rattus norvegicus	113-118
12773775-0	2003	Role of IL-1(beta) in endotoxin potentiation of deoxynivalenol-induced corticosterone response and leukocyte apoptosis in mice.	Corticosterone	71-85	interleukin 1 beta	Mus musculus	8-18
12792820-5	2003	In normoglycemic rats, glucagon increased basal aldosterone and corticosterone secretion from ZG and ZF/R cells, GLP-2 raised both basal and ACTH-stimulated aldosterone secretion and ACTH-stimulated corticosterone output, and EX4 increased basal corticosterone secretion.	Corticosterone	199-213	mast cell protease 10	Rattus norvegicus	113-118
12773775-3	2003	The purpose of this study was to test the hypothesis that interleukin-1beta (IL-1beta) plays a central role in corticosterone induction and subsequent leukocyte apoptosis in this model.	Corticosterone	111-125	interleukin 1 beta	Mus musculus	58-75
12773775-3	2003	The purpose of this study was to test the hypothesis that interleukin-1beta (IL-1beta) plays a central role in corticosterone induction and subsequent leukocyte apoptosis in this model.	Corticosterone	111-125	interleukin 1 beta	Mus musculus	77-85
12773775-9	2003	Plasma corticosterone levels and thymus and Peyer"s patch apoptosis in IL-1beta-injected mice were significantly higher at 12 h than in control mice.	Corticosterone	7-21	interleukin 1 beta	Mus musculus	71-79
12773775-11	2003	Taken together, the results indicate that IL-1beta is an important mediator of LPS plus DON-induced corticosterone and subsequent leukocyte apoptosis and, furthermore, this cytokine possibly acts through an ACTH-independent mechanism.	Corticosterone	100-114	interleukin 1 beta	Mus musculus	42-50
12773775-11	2003	Taken together, the results indicate that IL-1beta is an important mediator of LPS plus DON-induced corticosterone and subsequent leukocyte apoptosis and, furthermore, this cytokine possibly acts through an ACTH-independent mechanism.	Corticosterone	100-114	pro-opiomelanocortin-alpha	Mus musculus	207-211
12798956-7	2003	Although we did not specifically study the exact mechanism(s) of alpha-MSH-afforded postischemic protection, we assume that this protection may be related to alpha-MSH-induced corticosterone release and corticosterone-induced de novo protein synthesis, which reflected in the recovery of postischemic cardiac function in isolated hearts.	Corticosterone	176-190	proopiomelanocortin	Rattus norvegicus	65-74
12737930-1	2003	Corticosterone (CORT), the predominant glucocorticoid in rodents, elevated for 21 days damages hippocampal subregion CA3.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
12798956-7	2003	Although we did not specifically study the exact mechanism(s) of alpha-MSH-afforded postischemic protection, we assume that this protection may be related to alpha-MSH-induced corticosterone release and corticosterone-induced de novo protein synthesis, which reflected in the recovery of postischemic cardiac function in isolated hearts.	Corticosterone	176-190	proopiomelanocortin	Rattus norvegicus	158-167
12798956-7	2003	Although we did not specifically study the exact mechanism(s) of alpha-MSH-afforded postischemic protection, we assume that this protection may be related to alpha-MSH-induced corticosterone release and corticosterone-induced de novo protein synthesis, which reflected in the recovery of postischemic cardiac function in isolated hearts.	Corticosterone	203-217	proopiomelanocortin	Rattus norvegicus	65-74
12832725-0	2003	Effect of cyclooxygenase inhibitors on the vasopressin induced ACTH and corticosterone response during crowding stress.	Corticosterone	72-86	arginine vasopressin	Rattus norvegicus	43-54
12765951-3	2003	To assess the role of 11beta-HSD1-mediated synthesis of active corticosterone in leptin-related obesity and diabetes, we examined the peripheral effect of leptin on 11beta-HSD1 activity and gene expression in vivo and in vitro in hepatocytes from ob/ob mice and in liver of streptozotocin (STZ)-treated ob/ob mice.	Corticosterone	63-77	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	22-33
12765951-6	2003	This induction of 11beta-HSD1 expression corresponded to reduced levels of circulating corticosterone and weight loss in ob/ob mice treated with leptin, indicating that impaired hepatic 11beta-HSD1 expression may contribute to the pathogenesis of obesity in ob/ob mice.	Corticosterone	87-101	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	18-29
12717340-8	2003	Although insulin replacement restores ACTH and corticosterone levels to normal, likely through glucocorticoid-mediated suppression of ACTH secretion, CRH and MR mRNA expression remain elevated.	Corticosterone	47-61	insulin	Homo sapiens	9-16
12767484-4	2003	The dispersed cytoplasmic GR was again translocated into the nucleus by administration of CS.	Corticosterone	90-92	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	26-28
12845222-7	2003	When galanin was administered centrally, GALKOs had lower testosterone and corticosterone levels than did WT mice.	Corticosterone	75-89	galanin and GMAP prepropeptide	Mus musculus	5-12
12775327-4	2003	The SLA/Bru rats, which are behaviorally more anxious than the SHA/Bru animals, show hypertrophy of the adrenal glands but reduced synthesis and release of the stress-related corticosterone than the SHA/Bru animals.	Corticosterone	175-189	src-like adaptor	Rattus norvegicus	4-7
12697697-3	2003	IL-6 plays a causal role in the TPS-induced elevation in HPAA activity, because the sustained (8-18 h) increases in 1) plasma corticosterone, 2) plasma ACTH, and 3) induction of c-Fos in the hypothalamic paraventricular nucleus are all markedly blunted in IL-6-deficient (IL-6(-/-)) mice.	Corticosterone	126-140	interleukin 6	Mus musculus	0-4
12697697-4	2003	Peripheral administration of a neutralizing IL-6 antiserum inhibited the plasma corticosterone response of normal (C57BL/6) mice to hind limb inflammation to an extent similar to that seen in IL-6(-/-) mice, suggesting that the IL-6 responsible for the increased HPAA activity is produced, or acts, on the blood side of the blood-brain barrier.	Corticosterone	80-94	interleukin 6	Mus musculus	44-48
12786976-1	2003	The two neuropeptide Y (NPY) systems innervating the hypothalamic paraventrivular nucleus were examined regarding their roles in the prefeeding corticosterone peak developed under restricted daily feeding (RF).	Corticosterone	144-158	neuropeptide Y	Rattus norvegicus	24-27
12810535-0	2003	Neuropeptide W acts in brain to control prolactin, corticosterone, and growth hormone release.	Corticosterone	51-65	neuropeptide W	Rattus norvegicus	0-14
12782395-5	2003	A negative correlation between amygdalar CRH mRNA and plasma corticosterone levels was found in the 2-day cocaine withdrawn rats but not in control rats, suggesting that CRH neurons in the amygdala may be differentially responsive to glucocorticoids after chronic cocaine exposure and withdrawal.	Corticosterone	61-75	corticotropin releasing hormone	Rattus norvegicus	41-44
12782395-5	2003	A negative correlation between amygdalar CRH mRNA and plasma corticosterone levels was found in the 2-day cocaine withdrawn rats but not in control rats, suggesting that CRH neurons in the amygdala may be differentially responsive to glucocorticoids after chronic cocaine exposure and withdrawal.	Corticosterone	61-75	corticotropin releasing hormone	Rattus norvegicus	170-173
12752792-5	2003	First we observed that long-term potentiation was greatly impaired in both CA1 and dentate gyrus after 3 weeks of exposure to variable stress, when recorded under conditions where plasma corticosterone levels are low.	Corticosterone	187-201	carbonic anhydrase 1	Rattus norvegicus	75-78
12752792-6	2003	Second, administration of 100 nm corticosterone in vitro reduced synaptic plasticity in CA1 of control rats, but induced no further impairment of synaptic plasticity in chronically stressed rats.	Corticosterone	33-47	carbonic anhydrase 1	Rattus norvegicus	88-91
12730429-5	2003	After 5 wk, body and thymus weights in LPD group were reduced 26 and 30%, respectively, which was accompanied by a 505% increase in serum corticosterone.	Corticosterone	138-152	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Mus musculus	39-42
12684698-5	2003	Corticosterone secretion was not changed at 3 h. In contrast, at 24 h exposure ADM22-52 alone or with ADM decreased basal corticosterone secretion; ADM evoked a small rise in ACTH-stimulated corticosterone production, and the effect was annulled by ADM22-52.	Corticosterone	122-136	adrenomedullin	Rattus norvegicus	79-82
12684698-5	2003	Corticosterone secretion was not changed at 3 h. In contrast, at 24 h exposure ADM22-52 alone or with ADM decreased basal corticosterone secretion; ADM evoked a small rise in ACTH-stimulated corticosterone production, and the effect was annulled by ADM22-52.	Corticosterone	122-136	adrenomedullin	Rattus norvegicus	102-105
12689607-2	2003	Corticosterone (CORT), the glucocorticoid (GC) effector hormone of the HPA axis in rats, inhibits both proinflammatory cytokine production/release and activity of the HPA axis itself.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
12639937-6	2003	Subcutaneous corticosterone injections also resulted in significant suppression of CRF R2 mRNA levels in the pituitary, suggesting that glucocorticoids are involved in modulating CRF R2 mRNA levels in the pituitary under stress.	Corticosterone	13-27	corticotropin releasing hormone receptor 2	Rattus norvegicus	83-89
12676571-3	2003	Following TNF-alpha administration, the co-expression of corticotropin releasing hormone (CRH) and arginine vasopressin increased within the median eminence, peaking 7-14 days after treatment, and was associated with an early corticosterone sensitization.	Corticosterone	226-240	tumor necrosis factor	Homo sapiens	10-19
12676571-3	2003	Following TNF-alpha administration, the co-expression of corticotropin releasing hormone (CRH) and arginine vasopressin increased within the median eminence, peaking 7-14 days after treatment, and was associated with an early corticosterone sensitization.	Corticosterone	226-240	corticotropin releasing hormone	Homo sapiens	57-88
12676571-3	2003	Following TNF-alpha administration, the co-expression of corticotropin releasing hormone (CRH) and arginine vasopressin increased within the median eminence, peaking 7-14 days after treatment, and was associated with an early corticosterone sensitization.	Corticosterone	226-240	corticotropin releasing hormone	Homo sapiens	90-93
12676571-3	2003	Following TNF-alpha administration, the co-expression of corticotropin releasing hormone (CRH) and arginine vasopressin increased within the median eminence, peaking 7-14 days after treatment, and was associated with an early corticosterone sensitization.	Corticosterone	226-240	arginine vasopressin	Homo sapiens	108-119
12639937-6	2003	Subcutaneous corticosterone injections also resulted in significant suppression of CRF R2 mRNA levels in the pituitary, suggesting that glucocorticoids are involved in modulating CRF R2 mRNA levels in the pituitary under stress.	Corticosterone	13-27	corticotropin releasing hormone receptor 2	Rattus norvegicus	179-185
12642505-10	2003	ANG significantly increased plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone in dexamethasone-treated SHR but not in WKY.	Corticosterone	84-98	angiogenin	Rattus norvegicus	0-3
12778363-10	2003	Multiple linear regression analyses uncovered statistically significant inverse correlations between plasma VEGF and blood beta-hydroxybutyrate or serum corticosterone.	Corticosterone	153-167	vascular endothelial growth factor A	Rattus norvegicus	108-112
12527031-8	2003	The immunosuppressive effect of corticosterone and the mechanism of down-regulation on GcR are confirmed by the negative correlations with IFN-gamma production and GcR binding capacity.	Corticosterone	32-46	interferon gamma	Oryctolagus cuniculus	139-148
12665169-11	2003	Subcutaneous implantation of a corticosterone pellet in mice fed the control diet resulted in a significantly elevated serum leptin level compared with placebo-implanted controls.	Corticosterone	31-45	leptin	Mus musculus	125-131
12639701-7	2003	Data were discussed in the light of peripheral benzodiazepine receptor site (PBR) activation within adrenal gland cells by diazepam, thereby increasing the serum levels of corticosterone and thus reducing CIPE.	Corticosterone	172-186	translocator protein	Rattus norvegicus	77-80
12706289-1	2003	We reported that corticosterone (CORT) can induce differentiation of growth hormone (GH) cells in vitro and in vivo during chick embryonic development.	Corticosterone	17-31	CORT	Gallus gallus	33-37
12706289-1	2003	We reported that corticosterone (CORT) can induce differentiation of growth hormone (GH) cells in vitro and in vivo during chick embryonic development.	Corticosterone	17-31	growth hormone	Gallus gallus	69-83
12706289-1	2003	We reported that corticosterone (CORT) can induce differentiation of growth hormone (GH) cells in vitro and in vivo during chick embryonic development.	Corticosterone	17-31	growth hormone	Gallus gallus	85-87
12591118-4	2003	In situ hybridization revealed a reduction in CART mRNA levels in both the hypothalamic paraventricular and arcuate nuclei in adrenalectomized rats, which was fully restored upon dexamethasone treatment but not by a subcutaneous 25% corticosterone pellet.	Corticosterone	233-247	CART prepropeptide	Rattus norvegicus	46-50
12593932-0	2003	Mechanistic studies of the effect of hydroxypropyl-beta-cyclodextrin on in vitro transdermal permeation of corticosterone through hairless mouse skin.	Corticosterone	107-121	lysine demethylase and nuclear receptor corepressor	Mus musculus	130-138
12588515-4	2003	Injection of MCH directly into the paraventricular nucleus (PVN) was found to increase both circulating ACTH and corticosterone 10 min after injection.	Corticosterone	113-127	pro-melanin concentrating hormone	Homo sapiens	13-16
12642147-8	2003	POMC mRNA in anterior pituitary of nicotine-exposed GD 18 fetuses was reduced, probably as a result of corticosterone feedback.	Corticosterone	103-117	proopiomelanocortin	Rattus norvegicus	0-4
12562380-8	2003	Moreover, Stx2 injection was associated with a transient but significant rise in corticosterone secretion.	Corticosterone	81-95	syntaxin 2	Mus musculus	10-14
12604231-4	2003	In addition, the expression (by Western blots) and activity (reduction/oxidation of dehydrocorticosterone/corticosterone) of 11beta-HSD 1 in different male and female mouse tissues were investigated.	Corticosterone	91-105	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	125-137
12538613-5	2003	Here we show that cortisone and 11-dehydrocorticosterone, the main cortisol and corticosterone metabolites produced in the distal nephron, where sodium reabsorption stimulated by aldosterone takes place, bind with high affinity to MR(L810).	Corticosterone	42-56	nuclear receptor subfamily 3 group C member 2	Homo sapiens	231-233
12589376-6	2003	In HAB rats, the paroxetine-induced behavioral changes towards more active coping strategies were accompanied by a normalization of the CRH-stimulated increase in corticotropin (ACTH) and corticosterone secretion.	Corticosterone	188-202	corticotropin releasing hormone	Rattus norvegicus	136-139
12560126-14	2003	However, AVP mRNA levels were higher in corticosterone implanted rats post stress compared to cholesterol treated controls.	Corticosterone	40-54	arginine vasopressin	Rattus norvegicus	9-12
12560126-16	2003	Elevated basal levels of mpPVN CRF mRNA, and the induction of a mpPVN AVP mRNA response to the behavioral stressor implicate enhanced ACTH secretagogue expression in the increased HPA response to corticosterone modulation of amygdala function.	Corticosterone	196-210	arginine vasopressin	Rattus norvegicus	70-73
12668869-5	2003	Central administration of 1.0 and 3.0 nmol of PrRP-31, but only the higher dose of RFRP-1, significantly elevated serum corticosterone levels in conscious male rats.	Corticosterone	120-134	prolactin releasing hormone	Rattus norvegicus	46-50
12668869-14	2003	The corticosterone secretion observed following central administration of PrRP-31 does not appear, based on our current results, to be solely owing to an action of the peptide on CRH-producing neurons but, instead, may be a result of the ability of PrRP-31 to increase as well the exposure of the corticotrophs in vivo to other ACTH secretagogues, such as oxytocin or vasopressin.	Corticosterone	4-18	prolactin releasing hormone	Rattus norvegicus	74-78
12566491-0	2003	Leptin suppresses food intake and body weight in corticosterone-replaced adrenalectomized rats.	Corticosterone	49-63	leptin	Rattus norvegicus	0-6
12566491-4	2003	We wanted to establish the effect of varying doses of corticosterone (CORT) on body weight and food intake suppression by using separate groups of ADX, ADX and corticosterone-treated and sham-operated Sprague-Dawley rats.	Corticosterone	54-68	cortistatin	Rattus norvegicus	70-74
12711009-1	2003	The mineralocorticoid receptor (MR) binds aldosterone, but also glucocorticoid hormones (corticosterone in rodents, cortisol in humans), which largely prevail in the plasma.	Corticosterone	89-103	nuclear receptor subfamily 3 group C member 2	Homo sapiens	4-30
12711009-1	2003	The mineralocorticoid receptor (MR) binds aldosterone, but also glucocorticoid hormones (corticosterone in rodents, cortisol in humans), which largely prevail in the plasma.	Corticosterone	89-103	nuclear receptor subfamily 3 group C member 2	Homo sapiens	32-34
12711009-3	2003	We analyzed the effect of corticosterone or 11-dehydrocorticosterone (11-DHC) on the transactivation activity of the MR, transiently expressed in a new renal cell line expressing 11-HSD2.	Corticosterone	26-40	nuclear receptor subfamily 3 group C member 2	Homo sapiens	117-119
12711009-4	2003	We show that, because of its metabolism by 11-HSD2, corticosterone is a poor activator of MR transactivation, except at micromolar concentrations, where the enzyme is saturated.	Corticosterone	52-66	nuclear receptor subfamily 3 group C member 2	Homo sapiens	90-92
12543226-5	2003	In contrast, the hypothalamic-pituitary-adrenal (HPA) response was augmented further after the second shock session: plasma corticosterone (CORT) levels were 18.1, 316.5, and 441.6 mg/ml in nonstressed, one-footshock-, or two-footshock-treated rats, respectively.	Corticosterone	124-138	cortistatin	Rattus norvegicus	140-144
12601284-3	2003	In order to evaluate the mechanism of action of glucocorticoids and mineralocorticoids, we studied the comparative effects of corticosterone and aldosterone on the abundance of NHE3 and NHE2 isoforms.	Corticosterone	126-140	solute carrier family 9 member A3	Rattus norvegicus	177-181
12601284-3	2003	In order to evaluate the mechanism of action of glucocorticoids and mineralocorticoids, we studied the comparative effects of corticosterone and aldosterone on the abundance of NHE3 and NHE2 isoforms.	Corticosterone	126-140	solute carrier family 9 member A2	Rattus norvegicus	186-190
12601284-10	2003	Corticosterone-replacement enhanced NHE3 abundance by 76% and failed to increase NHE2.	Corticosterone	0-14	solute carrier family 9 member A3	Rattus norvegicus	36-40
21207869-0	2003	[The effect of corticosterone on LTP in CA1 area of rat hippocampal slices].	Corticosterone	15-29	carbonic anhydrase 1	Rattus norvegicus	40-43
12535647-2	2003	alpha-MSH stimulates corticosterone release from rat adrenal glomerulosa cells in vitro.	Corticosterone	21-35	proopiomelanocortin	Rattus norvegicus	0-9
12535647-6	2003	The effect of AgRP on alpha-MSH-induced corticosterone release was investigated using dispersed rat adrenal glomerulosa cells.	Corticosterone	40-54	agouti related neuropeptide	Rattus norvegicus	14-18
12535647-6	2003	The effect of AgRP on alpha-MSH-induced corticosterone release was investigated using dispersed rat adrenal glomerulosa cells.	Corticosterone	40-54	proopiomelanocortin	Rattus norvegicus	22-31
12535647-7	2003	AgRP administered alone did not affect corticosterone release, but co-administration of AgRP and alpha-MSH attenuated alpha-MSH-induced corticosterone release.	Corticosterone	136-150	agouti related neuropeptide	Rattus norvegicus	88-92
12535647-7	2003	AgRP administered alone did not affect corticosterone release, but co-administration of AgRP and alpha-MSH attenuated alpha-MSH-induced corticosterone release.	Corticosterone	136-150	proopiomelanocortin	Rattus norvegicus	97-106
12535647-7	2003	AgRP administered alone did not affect corticosterone release, but co-administration of AgRP and alpha-MSH attenuated alpha-MSH-induced corticosterone release.	Corticosterone	136-150	proopiomelanocortin	Rattus norvegicus	118-127
12535647-11	2003	AgRP acting via the MC3-R or MC4-R may have an inhibitory paracrine role, blocking alpha-MSH-induced corticosterone secretion.	Corticosterone	101-115	agouti related neuropeptide	Rattus norvegicus	0-4
12581887-1	2003	The high levels of corticosterone (CORT) that are typically achieved during stress induce apoptotic death of Leydig cells.	Corticosterone	19-33	cortistatin	Rattus norvegicus	35-39
12535647-11	2003	AgRP acting via the MC3-R or MC4-R may have an inhibitory paracrine role, blocking alpha-MSH-induced corticosterone secretion.	Corticosterone	101-115	melanocortin 3 receptor	Rattus norvegicus	20-25
12535647-11	2003	AgRP acting via the MC3-R or MC4-R may have an inhibitory paracrine role, blocking alpha-MSH-induced corticosterone secretion.	Corticosterone	101-115	melanocortin 4 receptor	Rattus norvegicus	29-34
12535647-11	2003	AgRP acting via the MC3-R or MC4-R may have an inhibitory paracrine role, blocking alpha-MSH-induced corticosterone secretion.	Corticosterone	101-115	proopiomelanocortin	Rattus norvegicus	83-92
12493574-2	2003	By flow cytometry analysis, treatment of PC12 cells with corticosterone (Cort) induced apoptosis in a concentration and time dependent manner.	Corticosterone	57-71	cortistatin	Rattus norvegicus	73-77
12614650-3	2003	SAL rather than LAL mice showed a clear fluctuation in circulating corticosterone concentrations around the circadian peak with significantly higher levels in the late light phase.	Corticosterone	67-81	lysosomal acid lipase A	Mus musculus	16-19
12485811-4	2003	A daily injection of ACTH-(1-39) restored the transcript for Flk-1/KDR and both VEGF(188) and plasma corticosterone to control levels.	Corticosterone	101-115	pro-opiomelanocortin-alpha	Mus musculus	21-25
12542666-1	2003	Single administration of the cytokine interleukin-1 alpha (IL-1), or the psychostimulant amphetamine, enhanced adrenocorticotropin hormone and corticosterone responses to a stress challenge weeks later.	Corticosterone	143-157	interleukin 1 alpha	Rattus norvegicus	38-57
12614650-6	2003	Forced swimming for 5 min induced high immobility behavior in LAL mice which was associated with an enhanced and prolonged corticosterone response as compared to SAL, while absolute ACTH levels did not differ.	Corticosterone	123-137	lysosomal acid lipase A	Mus musculus	62-65
12525251-4	2003	After treatment with 2 ng/ml TGFbeta1 for 24 h, basal production of corticosterone, cortisol and androstenedione was dramatically decreased.	Corticosterone	68-82	transforming growth factor beta 1	Homo sapiens	29-37
12538030-0	2003	Characterization of glucocorticoid receptor translocation, cytoplasmic IkappaB, nuclear NFkappaB, and activation of NFkappaB in T lymphocytes exposed to stress-inducible concentrations of corticosterone in vivo.	Corticosterone	188-202	nuclear receptor subfamily 3 group C member 1	Homo sapiens	20-43
12538030-0	2003	Characterization of glucocorticoid receptor translocation, cytoplasmic IkappaB, nuclear NFkappaB, and activation of NFkappaB in T lymphocytes exposed to stress-inducible concentrations of corticosterone in vivo.	Corticosterone	188-202	nuclear factor kappa B subunit 1	Homo sapiens	88-96
12538030-0	2003	Characterization of glucocorticoid receptor translocation, cytoplasmic IkappaB, nuclear NFkappaB, and activation of NFkappaB in T lymphocytes exposed to stress-inducible concentrations of corticosterone in vivo.	Corticosterone	188-202	nuclear factor kappa B subunit 1	Homo sapiens	116-124
12538030-1	2003	The present study was conducted to determine if selected events in glucocorticoid receptor (GR) signaling that have been identified using mostly in vitro approaches with synthetic glucocorticoids also occur in mature T cells exposed to relevant levels of corticosterone in vivo.	Corticosterone	255-269	nuclear receptor subfamily 3 group C member 1	Homo sapiens	67-90
12538030-1	2003	The present study was conducted to determine if selected events in glucocorticoid receptor (GR) signaling that have been identified using mostly in vitro approaches with synthetic glucocorticoids also occur in mature T cells exposed to relevant levels of corticosterone in vivo.	Corticosterone	255-269	nuclear receptor subfamily 3 group C member 1	Homo sapiens	92-94
12538030-2	2003	In contrast to effects reported in vitro, corticosterone did not cause significant translocation of GR to the nucleus in splenic T cells, though it did increase the amount of nuclear GR in these cells capable of binding to a glucocorticoid response element.	Corticosterone	42-56	nuclear receptor subfamily 3 group C member 1	Homo sapiens	183-185
12538030-5	2003	Corticosterone did not significantly inhibit the decrease in cytoplasmic IkappaB, but it did slightly diminish the increase in nuclear NFkappaB.	Corticosterone	0-14	nuclear factor kappa B subunit 1	Homo sapiens	135-143
14580931-2	2003	This effect might be mediated by corticosterone, because corticosterone administration is known to reduce hippocampal BDNF.	Corticosterone	33-47	brain-derived neurotrophic factor	Rattus norvegicus	118-122
14580931-2	2003	This effect might be mediated by corticosterone, because corticosterone administration is known to reduce hippocampal BDNF.	Corticosterone	57-71	brain-derived neurotrophic factor	Rattus norvegicus	118-122
14580933-0	2003	Estrogen receptor beta in the paraventricular nucleus of hypothalamus regulates the neuroendocrine response to stress and is regulated by corticosterone.	Corticosterone	138-152	estrogen receptor 2	Rattus norvegicus	0-22
14580933-2	2003	The present study tested whether 1) ERbeta in the paraventricular nucleus (PVN) of the hypothalamus has a direct role in the hypothalamic-pituitary-adrenal (HPA) axis-mediated stress function, and 2) whether corticosterone (CORT) can regulate ERbeta gene expression in the PVN in the intact, cycling female rat.	Corticosterone	208-222	estrogen receptor 2	Rattus norvegicus	36-42
12535959-1	2003	Single exposure to the proinflammatory cytokine interleukin-1 induces sensitization of the adrenocorticotropin hormone and corticosterone responses to stressors weeks later (hypothalamus-pituitary-adrenal sensitization).	Corticosterone	123-137	interleukin 1 alpha	Homo sapiens	48-61
12770571-6	2003	We could demonstrate that the CRHr1 is essential for the activation of the corticosterone response following maternal deprivation, most likely due to the lack of the receptor in the pituitary.	Corticosterone	75-89	corticotropin releasing hormone receptor 1	Mus musculus	30-35
14715455-0	2003	Corticosterone down-regulates dopamine D4 receptor in a mouse cerebral cortex neuronal cell line.	Corticosterone	0-14	dopamine receptor D4	Mus musculus	30-50
14715455-5	2003	We have investigated the effect of different concentrations of corticosterone on D4 dopamine receptor in immortalized cell lines from cerebral cortex of normal mouse fetuses, detected by immunocytochemistry employing polyclonal antibodies generated against synthetic peptides homologous to an extracellular domain of D4 receptor.	Corticosterone	63-77	dopamine receptor D4	Mus musculus	81-101
12468037-4	2002	In the first study effects of ADX and corticosterone replacement on POMC and AGRP expression were determined.	Corticosterone	38-52	proopiomelanocortin	Rattus norvegicus	68-72
12468037-4	2002	In the first study effects of ADX and corticosterone replacement on POMC and AGRP expression were determined.	Corticosterone	38-52	agouti related neuropeptide	Rattus norvegicus	77-81
12468037-6	2002	Corticosterone treatment increased the expression of POMC by 87% and AGRP by 45% in ADX rats.	Corticosterone	0-14	proopiomelanocortin	Rattus norvegicus	53-57
12468037-6	2002	Corticosterone treatment increased the expression of POMC by 87% and AGRP by 45% in ADX rats.	Corticosterone	0-14	agouti related neuropeptide	Rattus norvegicus	69-73
12480502-6	2002	Gp120 also induced a significant febrile response and increased serum levels of ACTH and corticosterone.	Corticosterone	89-103	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	0-5
12446609-9	2002	In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.	Corticosterone	23-37	interleukin 1 beta	Homo sapiens	76-84
12446609-9	2002	In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.	Corticosterone	23-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
12446609-9	2002	In contrast, exogenous corticosterone abolished the effects of ketorolac on IL-1beta-induced COX-2 and monocyte chemoattractant protein-1 gene expression in the cerebral endothelium.	Corticosterone	23-37	C-C motif chemokine ligand 2	Homo sapiens	103-137
12457455-9	2002	Expression of CYP11B1 in hyperfunctioning zona glomerulosa suggests an additional formation of corticosterone via 11beta-hydroxylase, providing further substrate for aldosterone biosynthesis.	Corticosterone	95-109	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	14-21
12510868-10	2002	Pretreatment with piroxicam (0.2-2.0 mg/kg), a COX-1 inhibitor, considerably diminished the nicotine-induced ACTH and corticosterone secretion in control and crowded rats.	Corticosterone	118-132	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	47-52
12535165-9	2003	These results provide evidence that metyrapone-induced corticosterone depletion elicits transsynaptic TH activation, implying noncholinergic neurotransmission.	Corticosterone	55-69	tyrosine hydroxylase	Rattus norvegicus	102-104
12510868-15	2002	Prostaglandins, generated by COX-1- but not by COX-2- isoenzyme, are of crucial significance in the nicotine-induced ACTH and corticosterone secretion in both control and stressed rats.	Corticosterone	126-140	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	29-34
12506852-2	2002	We demonstrated previously that a long-duration restraint stress (RTS) evoked adaptive change, characterized by transient increase and gradual recovery to basal level in c-fos mRNA/c-fos protein (Fos) expression in the hypothalamic paraventricular nucleus (PVN) and in plasma adrenocorticotropin (ACTH) levels, although circulating corticosterone (CORT) remained at a high level.	Corticosterone	332-346	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	170-175
12496947-0	2003	Flattening the corticosterone rhythm attenuates 5-HT1A autoreceptor function in the rat: relevance for depression.	Corticosterone	15-29	5-hydroxytryptamine receptor 1A	Rattus norvegicus	48-54
12496947-7	2003	Corticosterone treatment was found to induce a significant attenuation in the response to 8-OHDPAT, indicating functional desensitization of somatodendritic 5-HT(1A) autoreceptors.	Corticosterone	0-14	5-hydroxytryptamine receptor 1A	Rattus norvegicus	157-164
12506852-2	2002	We demonstrated previously that a long-duration restraint stress (RTS) evoked adaptive change, characterized by transient increase and gradual recovery to basal level in c-fos mRNA/c-fos protein (Fos) expression in the hypothalamic paraventricular nucleus (PVN) and in plasma adrenocorticotropin (ACTH) levels, although circulating corticosterone (CORT) remained at a high level.	Corticosterone	332-346	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	196-199
12399416-6	2002	Intra-PVN NMU markedly increased grooming and locomotor behavior and dose-dependently increased plasma ACTH (0.3 nmol NMU, 24.8 +/- 1.9 pg/ml; saline, 11.4 +/- 1.0; P &lt; 0.001) and corticosterone (0.3 nmol NMU, 275.4 +/- 40.5 ng/ml; saline, 129.4 +/- 25.0; P &lt; 0.01).	Corticosterone	183-197	neuromedin U	Homo sapiens	10-13
12718938-0	2002	IL-7-mediated protection of pro and pre-B cells from the adverse effects of corticosterone.	Corticosterone	76-90	interleukin 7	Homo sapiens	0-4
12718938-1	2002	The studies herein demonstrate that Interleukin-7 (IL-7) promotes survival of murine pro- and pre-B cells against stress levels of corticosterone (Cs).	Corticosterone	131-145	interleukin 7	Mus musculus	36-49
12718938-1	2002	The studies herein demonstrate that Interleukin-7 (IL-7) promotes survival of murine pro- and pre-B cells against stress levels of corticosterone (Cs).	Corticosterone	131-145	interleukin 7	Mus musculus	51-55
12718938-1	2002	The studies herein demonstrate that Interleukin-7 (IL-7) promotes survival of murine pro- and pre-B cells against stress levels of corticosterone (Cs).	Corticosterone	147-149	interleukin 7	Mus musculus	36-49
12718938-1	2002	The studies herein demonstrate that Interleukin-7 (IL-7) promotes survival of murine pro- and pre-B cells against stress levels of corticosterone (Cs).	Corticosterone	147-149	interleukin 7	Mus musculus	51-55
12718938-2	2002	In short-term, 16-h, bone marrow cultures IL-7 abrogated Cs-induced apoptosis and cell cycle arrest in pro-B cells by decreasing apoptosis 60% and completely restoring the cell cycle.	Corticosterone	57-59	interleukin 7	Homo sapiens	42-46
12718938-3	2002	IL-7 also reduced Cs-induced apoptosis by 36% in pre-B cells and 24% in IgM(+) B cells, but did not restore deficits in the cell cycle.	Corticosterone	18-20	interleukin 7	Homo sapiens	0-4
12718938-4	2002	Among pro- and pre- B cells, substantial protection against high, pharmacological, levels of Cs was also provided by IL-7.	Corticosterone	93-95	interleukin 7	Homo sapiens	117-121
12718938-6	2002	In conclusion, IL-7 has potential immunotherapeutic value since it provides substantial protection to pro- and pre-B cells against the adverse effects of Cs.	Corticosterone	154-156	interleukin 7	Homo sapiens	15-19
12409314-2	2002	Chronic overexpression of GH in transgenic mice results in systemically and locally increased IGF-I levels and in disproportionate overgrowth, including adrenocortical enlargement and corticosterone hypersecretion.	Corticosterone	184-198	growth hormone	Mus musculus	26-28
12409314-8	2002	Basal and ACTH-induced plasma corticosterone levels of 4-month-old G mice, but not of GB mice, were two- to threefold increased compared with C mice.	Corticosterone	30-44	pro-opiomelanocortin-alpha	Mus musculus	10-14
12401891-4	2002	Relative to apoe(+/+) mice, apoE deficiency also resulted in increased levels of plasma corticosterone in the basal state, in response to acute or long-term ACTH treatment, and after a swim-induced neuroendocrine-directed stress test.	Corticosterone	88-102	pro-opiomelanocortin-alpha	Mus musculus	157-161
12401891-8	2002	Further, these findings support the hypothesis that apoE acts to enhance adrenocortical EC accumulation and diminish corticosterone production.	Corticosterone	117-131	apolipoprotein E	Mus musculus	52-56
12421341-12	2002	groups, corticosterone concentrations exhibited a decline across groups: vehicle-sham&gt;leptin-sham&gt;ADX-vehicle&gt;ADX-leptin.	Corticosterone	8-22	leptin	Mus musculus	89-95
12421341-12	2002	groups, corticosterone concentrations exhibited a decline across groups: vehicle-sham&gt;leptin-sham&gt;ADX-vehicle&gt;ADX-leptin.	Corticosterone	8-22	leptin	Mus musculus	123-129
12403845-5	2002	In vivo, we show that CRH-deficient mice respond to lipopolysaccharide administration by reduced activation of thymus NF-kappaB, despite their significantly elevated proinflammatory cytokine and their low corticosterone levels.	Corticosterone	205-219	corticotropin releasing hormone	Mus musculus	22-25
12384241-5	2002	Treatment with IL-1beta diminished plasma growth hormone levels and increased circulating corticosterone levels irrespective of the animals stressor history.	Corticosterone	90-104	interleukin 1 beta	Mus musculus	15-23
12271144-7	2002	Additionally, infected MIF(-/-) mice showed elevated serum levels of nitric oxide and corticosterone as compared with control mice.	Corticosterone	86-100	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	23-26
12359311-0	2002	Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus.	Corticosterone	0-14	BCL2 associated X, apoptosis regulator	Rattus norvegicus	40-43
12359311-0	2002	Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus.	Corticosterone	0-14	BCL2, apoptosis regulator	Rattus norvegicus	45-50
12359311-0	2002	Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus.	Corticosterone	0-14	Bcl2-like 1	Rattus norvegicus	55-60
12472898-1	2002	This work reports the first demonstration that corticosterone (CORT) has a rapid and transient effect on NMDA receptor-mediated Ca2+ signaling in cultured rat hippocampal neurons.	Corticosterone	47-61	cortistatin	Rattus norvegicus	63-67
12417250-0	2002	Nociceptin/orphanin FQ and related peptides reduce the increase in plasma corticosterone elicited in mice by an intracerebroventricular injection.	Corticosterone	74-88	prepronociceptin	Mus musculus	11-22
12417250-5	2002	When N/OFQ was injected intracerebroventricularly, using a 1 microg dose, the increase in plasma corticosterone was significantly lower than in saline injected mice.	Corticosterone	97-111	prepronociceptin	Mus musculus	5-10
12417250-6	2002	N/OFQ(1-13)NH(2), known as a NOP receptor agonist, at the same 1 microg dose, also induced a lesser increase in plasma corticosterone level than a saline i.c.v.	Corticosterone	119-133	prepronociceptin	Mus musculus	0-5
12417250-9	2002	Finally, [Nphe(1)]N/OFQ(1-13)NH(2), although presumed to be a selective NOP receptor antagonist, also decreased the corticosterone level at the 0.1 microg dose.	Corticosterone	116-130	prepronociceptin	Mus musculus	18-23
12444901-12	2002	However, our results cast doubts on the possibility of direct adrenal actions of ligands of the GHS-R in the regulation of corticosterone secretion in the rat.	Corticosterone	123-137	growth hormone secretagogue receptor	Rattus norvegicus	96-101
12660884-5	2002	A reduction in leptin during fasting evoked a greater response in C57Bl/6J mice by decreasing energy expenditure and thyroxin, increasing corticosterone and stimulating food intake and weight gain during refeeding.	Corticosterone	138-152	leptin	Mus musculus	15-21
12384263-3	2002	These results suggest that corticosterone mediates the lasting effects of environmental challenges on apoE-genotype related cognitive performance.	Corticosterone	27-41	apolipoprotein E	Mus musculus	102-106
12385799-1	2002	Acute administration of corticosterone (Cort) has been shown to potentiate a variety of learning processes.	Corticosterone	24-38	cortistatin	Rattus norvegicus	40-44
12361860-5	2002	Corticosterone (CORT) (50, 150, and 300 ng/ml) resulted in significant increases in 5-HT3 expression which were attenuated by mifeprestone (50 ng/ml).	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
12359311-4	2002	After 5 days of ADX, there was a significant increase in bax mRNA levels in the suprapyramidal layer of the DG, an effect prevented by corticosterone replacement.	Corticosterone	135-149	BCL2 associated X, apoptosis regulator	Rattus norvegicus	57-60
12359311-6	2002	ADX increased bcl-2 mRNA levels, but only in the suprapyramidal layer of the DG, an effect that was prevented by corticosterone administration.	Corticosterone	113-127	BCL2, apoptosis regulator	Rattus norvegicus	14-19
12239090-3	2002	The secretion of ACTH induced by corticotropin-releasing factor (CRF; 0.1 nM) in primary cultures of rat anterior pituitary cells was markedly inhibited upon a 2-h exposure to 100 nM corticosterone.	Corticosterone	183-197	corticotropin releasing hormone	Rattus norvegicus	33-63
12239102-0	2002	Diurnal rhythm of agouti-related protein and its relation to corticosterone and food intake.	Corticosterone	61-75	agouti related neuropeptide	Rattus norvegicus	18-40
12239102-5	2002	Corticosterone secretion temporally coincided with the rising phase of AGRP mRNA expression.	Corticosterone	0-14	agouti related neuropeptide	Rattus norvegicus	71-75
12239102-6	2002	Depletion of corticosterone by adrenalectomy abolished the AGRP diurnal rhythm by suppressing the nighttime expression, but did not alter the feeding rhythm.	Corticosterone	13-27	agouti related neuropeptide	Rattus norvegicus	59-63
12239102-7	2002	Exposure of adrenalectomized rats to constant corticosterone replacement (10 or 50 mg continuous release corticosterone pellet) resulted in fixed AGRP mRNA expression throughout the 12-h light, 12-h dark cycle.	Corticosterone	46-60	agouti related neuropeptide	Rattus norvegicus	146-150
12239102-7	2002	Exposure of adrenalectomized rats to constant corticosterone replacement (10 or 50 mg continuous release corticosterone pellet) resulted in fixed AGRP mRNA expression throughout the 12-h light, 12-h dark cycle.	Corticosterone	105-119	agouti related neuropeptide	Rattus norvegicus	146-150
12239102-8	2002	A relatively high level of corticosterone (50 mg) significantly increased AGRP mRNA expression, with a positive correlation between these two measures.	Corticosterone	27-41	agouti related neuropeptide	Rattus norvegicus	74-78
12239102-9	2002	These results indicate that 1) the diurnal expression of AGRP mRNA is regulated by corticosterone independently of the light/dark cue; and 2) a normal endogenous corticosterone rhythm is required for generating the diurnal AGRP rhythm.	Corticosterone	83-97	agouti related neuropeptide	Rattus norvegicus	57-61
12239102-9	2002	These results indicate that 1) the diurnal expression of AGRP mRNA is regulated by corticosterone independently of the light/dark cue; and 2) a normal endogenous corticosterone rhythm is required for generating the diurnal AGRP rhythm.	Corticosterone	162-176	agouti related neuropeptide	Rattus norvegicus	57-61
12239102-9	2002	These results indicate that 1) the diurnal expression of AGRP mRNA is regulated by corticosterone independently of the light/dark cue; and 2) a normal endogenous corticosterone rhythm is required for generating the diurnal AGRP rhythm.	Corticosterone	162-176	agouti related neuropeptide	Rattus norvegicus	223-227
12439780-3	2002	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inert cortisone (11-dehydrocorticosterone in rodents) into active cortisol (corticosterone), thus amplifying intracellular GC action.	Corticosterone	93-107	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	0-55
12439781-3	2002	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inert cortisone (11-dehydrocorticosterone in rodents) into active cortisol (corticosterone), thus amplifying intracellular GC action.	Corticosterone	93-107	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-42
12439781-3	2002	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts inert cortisone (11-dehydrocorticosterone in rodents) into active cortisol (corticosterone), thus amplifying intracellular GC action.	Corticosterone	93-107	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	44-55
12458037-4	2002	Although dexamethasone ameliorated the mTNF-alpha-induced sensitization of corticosterone, illness behavior was unaffected.	Corticosterone	75-89	tumor necrosis factor	Mus musculus	39-49
12458044-3	2002	beta-Endorphin-deficient mice had attenuated increases of plasma ACTH and corticosterone levels in response to LPS.	Corticosterone	74-88	pro-opiomelanocortin-alpha	Mus musculus	0-14
12218159-6	2002	Such anti-inflammatory properties of circulating LPS are mediated via plasma corticosterone, because exogenous corticoids mimicked while glucocorticoid receptor antagonist RU486 prevented the effects of systemic endotoxin challenge.	Corticosterone	77-91	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	137-160
12370278-3	2002	PKCepsilon-null mice showed reduced anxiety-like behavior and reduced levels of the stress hormones corticosterone and adrenocorticotrophic hormone (ACTH).	Corticosterone	100-114	protein kinase C, epsilon	Mus musculus	0-10
12370278-5	2002	Treatment of PKCepsilon-null mice with the GABA(A) receptor antagonist bicuculline restored corticosterone levels and anxiety-like behavior to wild-type levels.	Corticosterone	92-106	protein kinase C, epsilon	Mus musculus	13-23
12237750-0	2002	Prolonged corticosterone treatment alters the responsiveness of 5-HT1A receptors to 8-OH-DPAT in rat CA1 hippocampal neurons.	Corticosterone	10-24	5-hydroxytryptamine receptor 1A	Rattus norvegicus	64-70
12237750-0	2002	Prolonged corticosterone treatment alters the responsiveness of 5-HT1A receptors to 8-OH-DPAT in rat CA1 hippocampal neurons.	Corticosterone	10-24	carbonic anhydrase 1	Rattus norvegicus	101-104
12237750-4	2002	Prolonged, but not acute treatment with corticosterone attenuated (+/-)-8-hydroxy-2-di- N-propylamino)tetralin hydrobromide (8-OH-DPAT)-induced inhibition of population spikes, and 8-OH-DPAT-induced hyperpolarization in rat CA1 hippocampal neurons.	Corticosterone	40-54	carbonic anhydrase 1	Rattus norvegicus	224-227
12237750-5	2002	Chronic, but not acute treatment with corticosterone also decreased 5-HT(1A) receptor binding in the CA1 region (in the ventral part only) and the dentate gyrus.	Corticosterone	38-52	carbonic anhydrase 1	Rattus norvegicus	101-104
12237750-7	2002	Only acute, but not prolonged treatment with corticosterone decreased the level of 5-HT(1A) receptor mRNA in the CA1 region and dentate gyrus of the hippocampus.	Corticosterone	45-59	carbonic anhydrase 1	Rattus norvegicus	113-116
12237750-9	2002	It is concluded that a chronically elevated level of corticosterone can induce functional desensitization of 5-HT(1A) receptors in the CA1 area of the hippocampus, although this effect is not always followed consequently by decreases in 5-HT(1A) receptor synthesis in this or other areas of the hippocampus.	Corticosterone	53-67	carbonic anhydrase 1	Rattus norvegicus	135-138
12323385-2	2002	The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus.	Corticosterone	165-179	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	62-78
12323385-2	2002	The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus.	Corticosterone	165-179	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	80-83
12323385-2	2002	The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus.	Corticosterone	165-179	protein kinase C, gamma	Rattus norvegicus	89-105
12323385-2	2002	The first objective of this work was to examine the effect of protein kinase A (PKA) and protein kinase C (PKC) inhibitors on morphine withdrawal-induced changes in corticosterone release (an index of the hypothalamus-pituitary-adrenocortical axis activity) and in catecholaminergic turnover in the paraventricular nucleus.	Corticosterone	165-179	protein kinase C, gamma	Rattus norvegicus	107-110
12323385-6	2002	However, pretreatment with the selective PKC inhibitor, calphostin-C significantly antagonized the corticosterone hypersecretion in morphine-withdrawn rats.	Corticosterone	99-113	protein kinase C, gamma	Rattus norvegicus	41-44
12458037-1	2002	Murine tumor necrosis factor-alpha (mTNF-alpha) results in the sensitization of mechanisms underlying plasma corticosterone activity and sickness behavior, the latter being reminiscent of septic or anaphylactic shock.	Corticosterone	109-123	tumor necrosis factor	Mus musculus	36-46
12458037-2	2002	The mTNF-alpha induced a sensitization of sickness and corticosterone in mice that was attenuated by pretreatment with the combinations of histamine H(1) (diphenhydramine, mepyramine) and H(2) (cimetidine) antagonists.	Corticosterone	55-69	tumor necrosis factor	Mus musculus	4-14
12234997-7	2002	In the studies analyzing cell cycle regulatory molecules, corticosterone treatment of cells resulted in a strong induction (up to approximately 10-fold over control; P &lt; 0.01) of KIP1/P27 together with a decrease (up to 98%; P &lt; 0.01) in cyclin-dependent kinase 4 (CDK4) and cyclin D1 protein levels.	Corticosterone	58-72	cyclin-dependent kinase inhibitor 1B	Mus musculus	182-186
12234997-7	2002	In the studies analyzing cell cycle regulatory molecules, corticosterone treatment of cells resulted in a strong induction (up to approximately 10-fold over control; P &lt; 0.01) of KIP1/P27 together with a decrease (up to 98%; P &lt; 0.01) in cyclin-dependent kinase 4 (CDK4) and cyclin D1 protein levels.	Corticosterone	58-72	cyclin-dependent kinase inhibitor 1B	Mus musculus	187-190
12234997-7	2002	In the studies analyzing cell cycle regulatory molecules, corticosterone treatment of cells resulted in a strong induction (up to approximately 10-fold over control; P &lt; 0.01) of KIP1/P27 together with a decrease (up to 98%; P &lt; 0.01) in cyclin-dependent kinase 4 (CDK4) and cyclin D1 protein levels.	Corticosterone	58-72	cyclin-dependent kinase 4	Mus musculus	244-269
12234997-7	2002	In the studies analyzing cell cycle regulatory molecules, corticosterone treatment of cells resulted in a strong induction (up to approximately 10-fold over control; P &lt; 0.01) of KIP1/P27 together with a decrease (up to 98%; P &lt; 0.01) in cyclin-dependent kinase 4 (CDK4) and cyclin D1 protein levels.	Corticosterone	58-72	cyclin-dependent kinase 4	Mus musculus	271-275
12234997-7	2002	In the studies analyzing cell cycle regulatory molecules, corticosterone treatment of cells resulted in a strong induction (up to approximately 10-fold over control; P &lt; 0.01) of KIP1/P27 together with a decrease (up to 98%; P &lt; 0.01) in cyclin-dependent kinase 4 (CDK4) and cyclin D1 protein levels.	Corticosterone	58-72	cyclin D1	Mus musculus	281-290
12234997-8	2002	Cells treated with corticosterone also showed an increased binding (up to 2.6-fold over control; P &lt; 0.01) of KIP1/P27 with CDK4, together with a strong decrease (up to 89%; P &lt; 0.01) in the kinase activity of the CDK4-cyclin D1 complex.	Corticosterone	19-33	cyclin-dependent kinase inhibitor 1B	Mus musculus	113-117
12234997-8	2002	Cells treated with corticosterone also showed an increased binding (up to 2.6-fold over control; P &lt; 0.01) of KIP1/P27 with CDK4, together with a strong decrease (up to 89%; P &lt; 0.01) in the kinase activity of the CDK4-cyclin D1 complex.	Corticosterone	19-33	cyclin-dependent kinase inhibitor 1B	Mus musculus	118-121
12234997-8	2002	Cells treated with corticosterone also showed an increased binding (up to 2.6-fold over control; P &lt; 0.01) of KIP1/P27 with CDK4, together with a strong decrease (up to 89%; P &lt; 0.01) in the kinase activity of the CDK4-cyclin D1 complex.	Corticosterone	19-33	cyclin-dependent kinase 4	Mus musculus	127-131
12234997-8	2002	Cells treated with corticosterone also showed an increased binding (up to 2.6-fold over control; P &lt; 0.01) of KIP1/P27 with CDK4, together with a strong decrease (up to 89%; P &lt; 0.01) in the kinase activity of the CDK4-cyclin D1 complex.	Corticosterone	19-33	cyclin-dependent kinase 4	Mus musculus	220-224
12072427-8	2002	Ketoconazole partially inhibited corticosterone-induced SXR-mediated transcription on the CYP3A4 promoter.	Corticosterone	33-47	nuclear receptor subfamily 1 group I member 2	Homo sapiens	56-59
12072427-8	2002	Ketoconazole partially inhibited corticosterone-induced SXR-mediated transcription on the CYP3A4 promoter.	Corticosterone	33-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	90-96
12234997-8	2002	Cells treated with corticosterone also showed an increased binding (up to 2.6-fold over control; P &lt; 0.01) of KIP1/P27 with CDK4, together with a strong decrease (up to 89%; P &lt; 0.01) in the kinase activity of the CDK4-cyclin D1 complex.	Corticosterone	19-33	cyclin D1	Mus musculus	225-234
12234997-9	2002	Treatment of cells with KIP1/P27 antisense oligonucleotides reversed the growth inhibitory effects of corticosterone.	Corticosterone	102-116	cyclin-dependent kinase inhibitor 1B	Mus musculus	24-28
12234997-9	2002	Treatment of cells with KIP1/P27 antisense oligonucleotides reversed the growth inhibitory effects of corticosterone.	Corticosterone	102-116	cyclin-dependent kinase inhibitor 1B	Mus musculus	29-32
12234997-10	2002	Treatment of cells with RU 486, a glucocorticoid receptor blocker, reversed the effects of corticosterone on cell growth and KIP/P27 protein levels suggesting the involvement of the glucocorticoid receptor in accounting for these effects.	Corticosterone	91-105	nuclear receptor subfamily 3, group C, member 1	Mus musculus	34-57
12234997-10	2002	Treatment of cells with RU 486, a glucocorticoid receptor blocker, reversed the effects of corticosterone on cell growth and KIP/P27 protein levels suggesting the involvement of the glucocorticoid receptor in accounting for these effects.	Corticosterone	91-105	nuclear receptor subfamily 3, group C, member 1	Mus musculus	182-205
12217933-10	2002	These data also provide further evidence for a dissociation between the activation of c-fos and corticotrophin-releasing factor (CRF) mRNA in the PVN, as we have previously demonstrated that this dose of cyanamide alone is sufficient to evoke a sustained increase in plasma corticosterone and an increase in CRF mRNA.	Corticosterone	274-288	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-91
12213137-0	2002	Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins.	Corticosterone	43-57	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	152-157
12213137-0	2002	Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins.	Corticosterone	43-57	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	162-167
12236633-0	2002	Corticosterone modulation of somatodendritic 5-HT1A receptor function in mice.	Corticosterone	0-14	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	45-60
12236633-3	2002	Daily injections (s.c.) of 50 mg/kg of corticosterone (CORT) for 3 days attenuates 8-OH-DPAT hypothermia tested 24 h later.	Corticosterone	39-53	cortistatin	Mus musculus	55-59
12369741-21	2002	), a COX-1 inhibitor, considerably impaired the carbachol-induced ACTH and corticosterone responses in control rats and markedly diminished these responses in stressed rats.	Corticosterone	75-89	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	5-10
12210834-2	2002	11beta-HSD1 converts biologically inactive 11-dehydrocorticosterone into active corticosterone.	Corticosterone	53-67	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-11
12218346-5	2002	In addition, in AT(2) receptor gene-disrupted mice there were higher plasma adrenocorticotropin (ACTH) and corticosterone levels and lower adrenal aldosterone content when compared to wild-type controls.	Corticosterone	107-121	angiotensin II receptor, type 2	Mus musculus	16-30
12181285-5	2002	The ensuing radioactive outflow from these cultures was enhanced by desipramine and reserpine, but reduced (in the presence of desipramine) by the OCT3 inhibitors cyanine 863, oestradiol and corticosterone.	Corticosterone	191-205	solute carrier family 22 member 3	Rattus norvegicus	147-151
12402971-7	2002	In addition to this, a set of in vitro experiments were also performed to identify the effects of metyrapone-induced corticosterone deficiency on hCG and prolactin-induced Leydig cell testosterone production.	Corticosterone	117-131	chorionic gonadotropin subunit beta 5	Homo sapiens	146-149
12153762-6	2002	A previous microarray experiment identified hepatic insulin-like growth factor binding protein 1 (IGF BP1) gene expression as consistently changed in correlation with serum corticosterone levels.	Corticosterone	173-187	insulin-like growth factor binding protein 1	Mus musculus	52-96
12153762-6	2002	A previous microarray experiment identified hepatic insulin-like growth factor binding protein 1 (IGF BP1) gene expression as consistently changed in correlation with serum corticosterone levels.	Corticosterone	173-187	insulin-like growth factor binding protein 1	Mus musculus	98-105
12402971-9	2002	It is concluded from the present study that the inhibitory effects of metyrapone-induced corticosterone deficiency on Leydig cell steroidogenesis are mediated through impaired glucose oxidation and 17beta-HSD activity.	Corticosterone	89-103	aldo-keto reductase family 1, member C12	Rattus norvegicus	198-208
12402971-10	2002	In vitro studies showed that corticosterone deficiency impairs not only hCG action but also the potentiating effect of prolactin on Leydig cell steroidogenesis.	Corticosterone	29-43	chorionic gonadotropin subunit beta 5	Homo sapiens	72-75
12884973-0	2002	Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge.	Corticosterone	62-76	corticotropin releasing hormone	Mus musculus	20-23
12884973-0	2002	Mice overexpressing CRH show reduced responsiveness in plasma corticosterone after a5-HT1A receptor challenge.	Corticosterone	62-76	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	84-99
12884973-7	2002	CRH injection, however, increased corticosterone levels in both groups.	Corticosterone	34-48	corticotropin releasing hormone	Mus musculus	0-3
12122087-0	2002	Interactions between heterotypic stressors and corticosterone reveal integrative mechanisms for controlling corticotropin-releasing hormone gene expression in the rat paraventricular nucleus.	Corticosterone	47-61	corticotropin releasing hormone	Rattus norvegicus	108-139
12450317-7	2002	On the other hand, CRH significantly increased serum concentrations of E2 and corticosterone in vivo in hypophysectomized rats, but this increase was completely blocked by adrenalectomy.	Corticosterone	78-92	corticotropin releasing hormone	Rattus norvegicus	19-22
12153464-0	2002	Annexin-1 (lipocortin-1)-immunoreactivity in the folliculo-stellate cells of rat anterior pituitary: the effect of adrenalectomy and corticosterone treatment on its subcellular distribution.	Corticosterone	133-147	annexin A1	Rattus norvegicus	0-9
12169769-8	2002	Splanchnic nerve transection also attenuated plasma corticosterone responses to submaximal doses of ACTH in dexamethasone-blocked, dehydrated rats, suggesting a decreased adrenal sensitivity to ACTH.	Corticosterone	52-66	proopiomelanocortin	Homo sapiens	100-104
12076720-3	2002	In NC100, handling abolished the temporal variations seen in open-field activity among the nonhandled subjects and reduced corticosterone (CORT) activation.	Corticosterone	123-137	cortistatin	Mus musculus	139-143
12076728-0	2002	Corticosterone administration to rat pups, but not maternal separation, affects sexual maturation and glucocorticoid receptor immunoreactivity in the testis.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	102-125
12122087-6	2002	In the second, we showed that negative feedback actions of corticosterone do not suppress CRH gene activation after hypovolemia, but instead determine the prestress lower limit of a range within which the CRH gene then responds.	Corticosterone	59-73	corticotropin releasing hormone	Rattus norvegicus	205-208
12122087-8	2002	First, the presence of corticosterone, which although permissive for appropriately activating the CRH gene during hypovolemia, does not mediate the suppressed gene response.	Corticosterone	23-37	corticotropin releasing hormone	Rattus norvegicus	98-101
12110607-10	2002	Corticosterone was about 100 fold more potent as inhibitor of hOCT3 than of hOCT1 or hOCT2, and O-methylisoprenaline (OMI) inhibited almost exclusively hOCT3.	Corticosterone	0-14	solute carrier family 22 member 3	Homo sapiens	62-67
12134101-8	2002	11betaHSD2 activity was assessed by determining the ratio of corticosterone to dehydrocorticosterone metabolites (THB+5alphaTHB)/THA in urine.	Corticosterone	61-75	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	0-10
12110607-16	2002	These compounds enable a functional discrimination of the three hOCTs: hOCT1 is selectively inhibited by prazosin, reversibly inhibited by PbA and it is not sensitive to inhibition by SKF550 and OMI; hOCT2 is reversibly inhibited by SKF550, irreversibly by PbA and not by prazosin, beta-oestradiol and OMI, whereas hOCT3 is selectively inhibited by corticosterone, OMI and decynium22.	Corticosterone	349-363	solute carrier family 22 member 1	Homo sapiens	71-76
12110607-10	2002	Corticosterone was about 100 fold more potent as inhibitor of hOCT3 than of hOCT1 or hOCT2, and O-methylisoprenaline (OMI) inhibited almost exclusively hOCT3.	Corticosterone	0-14	solute carrier family 22 member 1	Homo sapiens	76-81
21708752-7	2002	Premetamorphic and prometamorphic tadpoles of both species showed strong corticosterone responses to both shaking stress and ACTH injection.	Corticosterone	73-87	proopiomelanocortin S homeolog	Xenopus laevis	125-129
11953440-7	2002	The non-ionizable sterol, corticosterone, also inhibited hOCT2 activity, although it was neither competitive in nature nor was it sensitive to pH in the manner observed with weak bases.	Corticosterone	26-40	POU class 2 homeobox 2	Homo sapiens	57-62
11965357-9	2002	Taken together, the data indicate that administration of AS-ODN against alpha2A-ARs in the LC significantly reduced expression of alpha2A-AR mRNA in brain stem, moderately increased plasma corticosterone and had anxiolytic-like effect in the elevated plus-maze.	Corticosterone	189-203	adrenoceptor alpha 2A	Rattus norvegicus	72-82
12022960-8	2002	RESULTS: CRH-OE(2122) mice showed elevated basal plasma corticosterone concentrations, hypertrophy of the adrenal gland, and dexamethasone nonsuppression.	Corticosterone	56-70	corticotropin releasing hormone	Mus musculus	9-12
12020848-3	2002	administered SIN-1 (250 and 500 microg/animal) effectively and dose-dependently elevated plasma levels of corticosterone.	Corticosterone	106-120	MAPK associated protein 1	Homo sapiens	13-18
12020848-5	2002	), an alpha-adrenoceptor antagonist, attenuated the elevation of plasma corticosterone evoked by SIN-1, but sotalol (300 microg/animal, i.c.v.	Corticosterone	72-86	MAPK associated protein 1	Homo sapiens	97-102
12020848-9	2002	), a cyclooxygenase inhibitor, abolished the SIN-1-induced elevations of both noradrenaline in the PVN and plasma corticosterone.	Corticosterone	114-128	MAPK associated protein 1	Homo sapiens	45-50
12022960-10	2002	In reaction to stress, CRH-OE(2122) mice showed a normal corticosterone response.	Corticosterone	57-71	corticotropin releasing hormone	Mus musculus	23-26
12059986-9	2002	CONCLUSIONS: There is no evidence for an enhanced gene expression or activity of renal 11 beta-HSD2 in these aging rats, suggesting either that endogenous 11 beta-HSD2 is able to cope with the increased corticosterone concentrations characteristic of the aging process or that alternative mechanisms contribute to the maintenance of a normal sodium excretion in these animals.	Corticosterone	203-217	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	155-167
12201221-8	2002	These results indicate the negative effect of the adrenal glands, which is probably due to corticosterone, on PRL release in pseudopregnant rats and that the early relief of this inhibition extends the duration of pseudopregnancy.	Corticosterone	91-105	prolactin	Rattus norvegicus	110-113
12039706-4	2002	DESIGN: Female pups were given subcutaneous injections of corticosterone (5 mg/kg, CORT) or vehicle 3 and 5 days after birth.	Corticosterone	58-72	cortistatin	Rattus norvegicus	83-87
12039706-7	2002	CORT rats had lower basal corticosterone levels and lower corticosterone levels 15 and 90 min after exposure to stress.	Corticosterone	26-40	cortistatin	Rattus norvegicus	0-4
12039706-7	2002	CORT rats had lower basal corticosterone levels and lower corticosterone levels 15 and 90 min after exposure to stress.	Corticosterone	58-72	cortistatin	Rattus norvegicus	0-4
12047726-9	2002	Basal adrenocorticotropic hormone (ACTH) release is regulated by testosterone-dependent effects on arginine vasopressin synthesis, and corticosterone-dependent effects on corticotropin-releasing hormone (CRH) synthesis in the paraventricular nucleus (PVN) of the hypothalamus.	Corticosterone	135-149	corticotropin releasing hormone	Homo sapiens	171-202
12120902-11	2002	Pretreatment with piroxicam (0.2-2.0 mg/kg), a COX-1 inhibitor, considerably impaired the nicotine-induced ACTH and corticosterone secretion.	Corticosterone	116-130	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	47-52
12120902-14	2002	Noradrenaline, stimulating postsynaptic alpha1-adrenergic receptors, and prostaglandins, synthesized by COX-1 isoenzyme, are of crucial significance in the nicotine-induced ACTH and corticosterone secretion.	Corticosterone	182-196	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	104-109
12066582-5	2002	The activation of the hypothalamic-pituitary-adrenal (HPA) axis during stress resulted in rapid increases in the plasma levels of adrenocorticotropic hormone (ACTH) and corticosterone (CORT).	Corticosterone	169-183	cortistatin	Rattus norvegicus	185-189
12047726-9	2002	Basal adrenocorticotropic hormone (ACTH) release is regulated by testosterone-dependent effects on arginine vasopressin synthesis, and corticosterone-dependent effects on corticotropin-releasing hormone (CRH) synthesis in the paraventricular nucleus (PVN) of the hypothalamus.	Corticosterone	135-149	corticotropin releasing hormone	Homo sapiens	204-207
12047726-10	2002	In contrast, testosterone and corticosterone interact on stress-induced ACTH release and drive to the PVN motor neurones.	Corticosterone	30-44	proopiomelanocortin	Homo sapiens	72-76
12138009-8	2002	In turn, it appears that endogenous GRP and CRF receptor ligands are both simultaneously involved in the regulation of the increase in 5-HT neuronal activity, ACTH and corticosterone secretion, under stress conditions.	Corticosterone	168-182	gastrin releasing peptide	Rattus norvegicus	36-39
12585192-0	2002	[Comparative study of modulating effect of kidney tonifying recipe and spleen invigorating recipe on T-lymphocyte apoptosis in corticosterone treated rats].	Corticosterone	127-141	RT1 class Ib, locus T18	Rattus norvegicus	101-123
12585192-1	2002	OBJECTIVE: To compare the modulating effect of Kidney tonifying recipe (KTR) and Spleen invigorating recipe (SIR) on T-lymphocyte apoptosis (TLA) in corticosterone treated rats (CTR).	Corticosterone	149-163	RT1 class Ib, locus T18	Rattus norvegicus	141-144
11959675-2	2002	On days 3 and 7 after induction of colitis, the corticotropin-releasing hormone (CRH) mRNA level in the parvocellular paraventricular nucleus (pPVN) of the hypothalamus was reduced, the plasma ACTH level remained at the basal level, and the plasma corticosterone (Cort) level was high.	Corticosterone	248-262	corticotropin releasing hormone	Rattus norvegicus	81-84
11959675-2	2002	On days 3 and 7 after induction of colitis, the corticotropin-releasing hormone (CRH) mRNA level in the parvocellular paraventricular nucleus (pPVN) of the hypothalamus was reduced, the plasma ACTH level remained at the basal level, and the plasma corticosterone (Cort) level was high.	Corticosterone	264-268	corticotropin releasing hormone	Rattus norvegicus	81-84
11934677-4	2002	In LIF knockout (LIFKO) mice, induction of both ACTH and corticosterone were attenuated.	Corticosterone	57-71	leukemia inhibitory factor	Mus musculus	3-6
12175593-9	2002	Previously defeated rats responded to the high dose of LPS with a deficient corticosterone (CORT) response resulting in an aggravated interleukin-1beta (IL-1beta) response 4 h after LPS injection.	Corticosterone	76-90	interleukin 1 beta	Rattus norvegicus	134-151
12175593-9	2002	Previously defeated rats responded to the high dose of LPS with a deficient corticosterone (CORT) response resulting in an aggravated interleukin-1beta (IL-1beta) response 4 h after LPS injection.	Corticosterone	92-96	interleukin 1 beta	Rattus norvegicus	134-151
12175593-9	2002	Previously defeated rats responded to the high dose of LPS with a deficient corticosterone (CORT) response resulting in an aggravated interleukin-1beta (IL-1beta) response 4 h after LPS injection.	Corticosterone	92-96	interleukin 1 beta	Rattus norvegicus	153-161
11943827-6	2002	Furthermore, the ability of DMI to suppress an acute corticosterone response after swim stress is maintained in CREB-deficient mice.	Corticosterone	53-67	cAMP responsive element binding protein 1	Mus musculus	112-116
11981059-5	2002	We hypothesize that this mechanism is a reduced 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) activity, a phenomenon known to cause enhanced access of cortisol or corticosterone to the mineralocorticoid receptor.	Corticosterone	169-183	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	48-85
11981059-5	2002	We hypothesize that this mechanism is a reduced 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) activity, a phenomenon known to cause enhanced access of cortisol or corticosterone to the mineralocorticoid receptor.	Corticosterone	169-183	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	87-98
11981059-5	2002	We hypothesize that this mechanism is a reduced 11beta-hydroxysteroid dehydrogenase 2 (11beta-HSD2) activity, a phenomenon known to cause enhanced access of cortisol or corticosterone to the mineralocorticoid receptor.	Corticosterone	169-183	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	191-217
11993792-0	2002	Preclinical Cushing"s syndrome due to ACTH-independent bilateral macronodular adrenocortical hyperplasia with excessive secretion of 18-hydroxydeoxycorticosterone and corticosterone.	Corticosterone	148-162	proopiomelanocortin	Homo sapiens	38-42
11931857-7	2002	D-MDMA increased the striatal levels of the astrocyte-localized protein glial fibrillary acidic protein (GFAP, a marker of gliosis); both dosages of corticosterone exacerbated this increase but only the 15 mg pellet exacerbated the decrease in tyrosine hydroxylase protein.	Corticosterone	149-163	glial fibrillary acidic protein	Mus musculus	72-103
11882498-7	2002	Plasma corticosterone was significantly higher in leptin-treated CR vs. MA mice.	Corticosterone	7-21	leptin	Mus musculus	50-56
11993792-1	2002	A 64-year-old woman developed hypertension and hypokalemia, due to ACTH-independent bilateral macronodular adrenocortical hyperplasia (AIMAH) with excessive secretion of 18-hydroxydeoxycorticosterone and corticosterone.	Corticosterone	185-199	proopiomelanocortin	Homo sapiens	67-71
11933049-6	2002	Moreover, the plasma corticosterone level under restraint stress was elevated in NMB-R-deficient mice compared to wild-type mice.	Corticosterone	21-35	neuromedin B receptor	Mus musculus	81-86
11963830-1	2002	In adrenalectomized (ADX) rats, either corticosterone replacement or increased sucrose intake will restore body weight gain, uncoupling protein-1, fat depot mass, food intake and corticotropin-releasing factor mRNA expression to normal.	Corticosterone	39-53	uncoupling protein 1	Rattus norvegicus	125-145
11963830-1	2002	In adrenalectomized (ADX) rats, either corticosterone replacement or increased sucrose intake will restore body weight gain, uncoupling protein-1, fat depot mass, food intake and corticotropin-releasing factor mRNA expression to normal.	Corticosterone	39-53	corticotropin releasing hormone	Rattus norvegicus	179-209
11979051-3	2002	Intraparaventricular nuclear (iPVN) injection of [Nle(4),D-Phe(7)]-alpha-MSH (NDP-MSH) (a long-acting alpha-MSH analogue) increased plasma adrenocorticotropic hormone (ACTH) (10 min post-injection: 25.0 +/- 3.9 vs. saline 10.9 +/- 2.0, p &lt; 0.05) and plasma corticosterone (10 min post-injection: 174.1 +/- 14.2 vs. saline 124.7 +/- 16.3 ng/ml, p &lt; 0.05).	Corticosterone	260-274	proopiomelanocortin	Rattus norvegicus	67-76
11967631-6	2002	In addition, serum corticosterone (CORT) levels were measured at various time points following injection of saline or ethanol.	Corticosterone	19-33	cortistatin	Mus musculus	35-39
12058538-2	2002	The defensins are known to display corticostatic activity by means of suppression of stress- and ACTH-induced rise in corticosterone level in the blood.	Corticosterone	118-132	proopiomelanocortin	Homo sapiens	97-101
11883945-5	2002	Compared to saline control, apelin-13 (10 nmol) significantly increased plasma ACTH and corticosterone and decreased plasma prolactin, LH and FSH at 30 min.	Corticosterone	88-102	apelin	Rattus norvegicus	28-34
11918848-1	2002	AIM: To investigate the nongenomic effect of the glucocorticoid corticosterone on nicotinic acetylcholine receptor (nAChR) in PC12 cells.	Corticosterone	64-78	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	82-114
11918848-1	2002	AIM: To investigate the nongenomic effect of the glucocorticoid corticosterone on nicotinic acetylcholine receptor (nAChR) in PC12 cells.	Corticosterone	64-78	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	116-121
11832364-6	2002	The relative activities of the three reactions catalyzed by CYP11B2 (11beta-hydroxylation of deoxycorticosterone, 18-hydroxylation of corticosterone, and dehydrogenation of 18-hydroxycorticosterone) were estimated after incubation of transfected cells with [(14)C]deoxycorticosterone and analysis of radioactivity associated with deoxycorticosterone, corticosterone, 18 hydroxycorticosterone, and aldosterone.	Corticosterone	98-112	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	60-67
11832364-6	2002	The relative activities of the three reactions catalyzed by CYP11B2 (11beta-hydroxylation of deoxycorticosterone, 18-hydroxylation of corticosterone, and dehydrogenation of 18-hydroxycorticosterone) were estimated after incubation of transfected cells with [(14)C]deoxycorticosterone and analysis of radioactivity associated with deoxycorticosterone, corticosterone, 18 hydroxycorticosterone, and aldosterone.	Corticosterone	134-148	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	60-67
11895881-3	2002	We investigated the role of adrenal glands and corticosterone in the DER effect on ERK activity.	Corticosterone	47-61	mitogen-activated protein kinase 1	Mus musculus	83-86
11895881-6	2002	In a parallel study, Adx mice were provided with 60 microg/ml corticosterone in the drinking water to test the hypothesis that corticosterone from the adrenal gland plays a key role in the DER inhibition of ERK in mice with intact adrenal glands.	Corticosterone	127-141	mitogen-activated protein kinase 1	Mus musculus	207-210
11895881-9	2002	Addition of corticosterone in the drinking water restored plasma hormone level and markedly decreased TPA-induced ERK activity in Adx mice (P &lt; 0.05).	Corticosterone	12-26	mitogen-activated protein kinase 1	Mus musculus	114-117
11895881-10	2002	These results provide strong evidence that intact adrenal glands are essential for the DER inhibition of ERK induction by TPA and that corticosterone plays a critical role in the DER blockage of ERK induction.	Corticosterone	135-149	mitogen-activated protein kinase 1	Mus musculus	195-198
12154575-3	2002	By contrast, the maximum corticosterone level was the same in plasma of both groups after interleukin-2 treatment, although the time patterns of the response were different.	Corticosterone	25-39	interleukin 2	Rattus norvegicus	90-103
11979051-3	2002	Intraparaventricular nuclear (iPVN) injection of [Nle(4),D-Phe(7)]-alpha-MSH (NDP-MSH) (a long-acting alpha-MSH analogue) increased plasma adrenocorticotropic hormone (ACTH) (10 min post-injection: 25.0 +/- 3.9 vs. saline 10.9 +/- 2.0, p &lt; 0.05) and plasma corticosterone (10 min post-injection: 174.1 +/- 14.2 vs. saline 124.7 +/- 16.3 ng/ml, p &lt; 0.05).	Corticosterone	260-274	norrin cystine knot growth factor NDP	Rattus norvegicus	78-81
11979051-5	2002	The combination of NDP-MSH and Agrp(83-132) administered iPVN significantly increased plasma ACTH (10 min post-injection: 21.3 +/- 3.8 vs. 10.9 +/- 2.0, p &lt; 0.05) and plasma corticosterone (10 min post-injection: 169.0 +/- 15.1 vs. saline 124.7 +/- 16.3 ng/ml, p &lt; 0.05), but there was no additive effect.	Corticosterone	177-191	norrin cystine knot growth factor NDP	Rattus norvegicus	19-22
11979051-5	2002	The combination of NDP-MSH and Agrp(83-132) administered iPVN significantly increased plasma ACTH (10 min post-injection: 21.3 +/- 3.8 vs. 10.9 +/- 2.0, p &lt; 0.05) and plasma corticosterone (10 min post-injection: 169.0 +/- 15.1 vs. saline 124.7 +/- 16.3 ng/ml, p &lt; 0.05), but there was no additive effect.	Corticosterone	177-191	agouti related neuropeptide	Rattus norvegicus	31-35
11861500-3	2002	Female HSL -/- mice showed a reduction in stimulated corticosterone values.	Corticosterone	53-67	lipase, hormone sensitive	Mus musculus	7-10
11918665-3	2002	A time-dependent sensitization was induced in mice, wherein reexposure to mTNF-alpha 28 days (but not 1 day) following the initial cytokine treatment provoked marked signs of illness (diminished activity, ptosis, piloerection) and increased plasma corticosterone levels.	Corticosterone	248-262	tumor necrosis factor	Mus musculus	74-84
11918665-6	2002	; 1-500 ng) mTNF-alpha did not promote illness, but modestly increased plasma corticosterone levels.	Corticosterone	78-92	tumor necrosis factor	Mus musculus	12-22
11918665-16	2002	It is suggested that the sensitization with respect to sickness and corticosterone activity in response to mTNF-alpha reflect the involvement of peripheral mechanisms.	Corticosterone	68-82	tumor necrosis factor	Mus musculus	107-117
11958817-2	2002	The present study examined the role of IL-6 in the development of corticosterone resistance.	Corticosterone	66-80	interleukin 6	Mus musculus	39-43
11874700-8	2002	The apparent K(m) of 11 beta-HSD2 for corticosterone increased from 47 +/- 11 nM in non-pregnant myometrium to 75 +/- 7 nM by day 10 of pregnancy, and remained high until returning to an intermediate level on the day of delivery (60 +/- 8 nM).	Corticosterone	38-52	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	21-33
11849760-4	2002	Individually-deprived rats exhibited the highest corticosterone (CORT) levels at 0 min.	Corticosterone	49-63	cortistatin	Rattus norvegicus	65-69
11874708-10	2002	The P(50) for corticosterone synthesis was approximately 28 mmHg and &lt;7 mmHg in ZFR cells from 7- and 42-day-old cells respectively.	Corticosterone	14-28	zinc finger RNA binding protein	Rattus norvegicus	83-86
11943505-1	2002	Fetal alcohol-exposed (FAE) rats exhibit heightened hormonal and behavioral stress responses, strikingly similar to those caused by exposure to elevated maternal corticosterone (CORT).	Corticosterone	162-176	cortistatin	Rattus norvegicus	178-182
11849373-9	2002	These data suggest that in PM rats, an elevation of basal concentrations of corticosterone, in face of reduced CBG and probably increased hippocampal MR lead to a much larger impact of corticosterone on target cells that mediate the negative-feedback mechanism on the activities of both the HPA axis and sympathoadrenal one.	Corticosterone	76-90	serpin family A member 6	Rattus norvegicus	111-114
11850143-2	2002	The main purpose the present study was, therefore, to determine the effects of psychostimulant cross-sensitization on the stress-induced release of adrenocorticotropic hormone (ACTH) and corticosterone (CORT).	Corticosterone	187-201	cortistatin	Rattus norvegicus	203-207
11841241-8	2002	Interestingly, 11beta-HSD 1 exhibits Michaelis-Menten kinetics with cortisol and corticosterone (11beta-dehydrogenation activity) but cooperative kinetics with cortisone and dehydrocorticosterone (11-oxoreducing activity).	Corticosterone	81-95	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	15-27
11788379-1	2002	We investigated the effects of ablation of the suprachiasmatic nucleus (SCN) on corticosterone (CORT) responses to synthetic ACTH given in either the morning or evening.	Corticosterone	80-94	cortistatin	Rattus norvegicus	96-100
11796523-7	2002	SF-1(+/-) mice had elevated ACTH and the lowest corticosterone following restraint stress.	Corticosterone	48-62	splicing factor 1	Mus musculus	0-4
11796523-8	2002	In contrast, Dax-1(-/Y) mice had elevated corticosterone and decreased ACTH.	Corticosterone	42-56	nuclear receptor subfamily 0, group B, member 1	Mus musculus	13-18
11796523-10	2002	In accordance with these findings, ACTH stimulation testing resulted in the highest levels of corticosterone in the Dax-1(-/Y) mice.	Corticosterone	94-108	pro-opiomelanocortin-alpha	Mus musculus	35-39
11796523-10	2002	In accordance with these findings, ACTH stimulation testing resulted in the highest levels of corticosterone in the Dax-1(-/Y) mice.	Corticosterone	94-108	nuclear receptor subfamily 0, group B, member 1	Mus musculus	116-121
11804612-0	2002	Comparison of the potency of MDL 100,907 and SB 242084 in blocking the serotonin (5-HT)(2) receptor agonist-induced increases in rat serum corticosterone concentrations: evidence for 5-HT(2A) receptor mediation of the HPA axis.	Corticosterone	139-153	5-hydroxytryptamine receptor 2A	Rattus norvegicus	71-99
11804612-1	2002	Direct-acting serotonin (5-HT) receptor agonists increase serum corticosterone in rats by activating receptors of the 5-HT(1A) or the 5-HT(2A/2C) subtypes.	Corticosterone	64-78	5-hydroxytryptamine receptor 1A	Rattus norvegicus	118-125
11878184-5	2002	A higher-plasma level of corticosterone, an endogenous P-gp substrate/inhibitor, was observed in the disease rats.	Corticosterone	25-39	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	55-59
11878184-6	2002	These findings indicate that the actual in vivo function of P-gp cannot be predicted merely from the expression level of P-gp, and suggest that some endogenous P-gp-related compounds such as corticosterone participate in the regulation of in vivo P-gp function in diseased states.	Corticosterone	191-205	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	60-64
11878184-6	2002	These findings indicate that the actual in vivo function of P-gp cannot be predicted merely from the expression level of P-gp, and suggest that some endogenous P-gp-related compounds such as corticosterone participate in the regulation of in vivo P-gp function in diseased states.	Corticosterone	191-205	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	121-125
11878184-6	2002	These findings indicate that the actual in vivo function of P-gp cannot be predicted merely from the expression level of P-gp, and suggest that some endogenous P-gp-related compounds such as corticosterone participate in the regulation of in vivo P-gp function in diseased states.	Corticosterone	191-205	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	121-125
11878184-6	2002	These findings indicate that the actual in vivo function of P-gp cannot be predicted merely from the expression level of P-gp, and suggest that some endogenous P-gp-related compounds such as corticosterone participate in the regulation of in vivo P-gp function in diseased states.	Corticosterone	191-205	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	121-125
11890958-6	2002	The second study revealed significantly higher plasma corticosterone (CORT) among LoS rats relative to HiS rats, both in the light and in the dark.	Corticosterone	54-68	cortistatin	Rattus norvegicus	70-74
11823896-4	2002	Brain 5-HT function was assessed by measuring the corticosterone/cortisol response to the 5-HT precursor, 5-hydroxytryptophan (5-HTP), a response believed to be mediated via indirect activation of 5-HT(2A) receptors.	Corticosterone	50-64	POU class 6 homeobox 1	Homo sapiens	0-7
21179828-1	2002	AIM: To investigate the roles of acetylcholine (ACh) receptors in the rapid effects of corticosterone (CORT) on the presympathetic neurons in the rostral ventrolateral medulla (RVLM) of rats, and study the non-genomic mechanism of glucocorticoid (GC) in the integration of sympathetic cardiovascular activity.	Corticosterone	87-101	cortistatin	Rattus norvegicus	103-107
21179840-7	2002	The inhibitory effect of corticosterone is independent of protein synthesis and intracellular glucocorticoid receptor.	Corticosterone	25-39	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	94-117
11796160-3	2002	SI was found to increase circulating plasma levels of corticosterone (CORT) and allopregnanolone (3-alpha,5-alpha-pregnan-20-one; 3,5-THP) at 1 h after separation on the fourth day, indicating that the isolation was an effective stressor.	Corticosterone	54-68	cortistatin	Rattus norvegicus	70-74
11799248-3	2002	Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion.	Corticosterone	0-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	127-131
11799248-3	2002	Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion.	Corticosterone	0-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
11799248-3	2002	Corticosterone, anticholinesterases, and forced swim, each facilitated a rapid (minutes), yet long-lasting (weeks), shift from AChE-S to the normally rare AChE-R mRNA, promoted AChE-R mRNA translocation into neurites, and induced enzyme secretion.	Corticosterone	0-14	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
11849820-2	2002	This study investigated whether the ACTH and corticosterone responses to tumor necrosis factor (TNF)-alpha and IL-6, two principal proinflammatory cytokines, are also modulated by the sex steroid milieu in the rat.	Corticosterone	45-59	tumor necrosis factor	Rattus norvegicus	73-106
11849820-2	2002	This study investigated whether the ACTH and corticosterone responses to tumor necrosis factor (TNF)-alpha and IL-6, two principal proinflammatory cytokines, are also modulated by the sex steroid milieu in the rat.	Corticosterone	45-59	interleukin 6	Rattus norvegicus	111-115
11849820-5	2002	TNF-alpha induced significantly higher responses of ACTH and corticosterone in females than in males, and this sexual difference was abolished by gonadectomy in both sexes.	Corticosterone	61-75	tumor necrosis factor	Rattus norvegicus	0-9
12234101-0	2002	Expression of prolactin receptors and regulation of cell proliferation by prolactin, corticotropin-releasing factor, and corticosterone in a neuroblastoma cell line.	Corticosterone	121-135	prolactin	Mus musculus	14-23
11756335-5	2002	Basal plasma corticosterone and insulin levels were increased by ICV NPY infusion, whereas HS014-infused rats showed no significant increase in these parameters on any of 1-6 days of infusion.	Corticosterone	13-27	neuropeptide Y	Rattus norvegicus	69-72
11751601-4	2002	In the first set of experiments, PLC, ILC, and ALC were treated with 100 nM corticosterone (CORT) for either 4 or 24 h in vitro and then assessed for labeling with the apoptotic marker annexin V.	Corticosterone	76-90	cortistatin	Rattus norvegicus	92-96
11751610-5	2002	Enzyme activity studies demonstrated that 11betaHSD1 acted as a reductase only, converting biologically inactive 11-dehydrocorticosterone to corticosterone, which then stimulated serum and glucocorticoid-induced kinase gene transcription via GR.	Corticosterone	123-137	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	42-52
12025787-7	2002	The higher content of corticosterone in LR rats leads to an increase in the concentration of cytochrome P-450 and stimulates the enzymatic activity of 3A isoforms in the liver tissues.	Corticosterone	22-36	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	93-109
11784300-4	2002	Genes encoding 3 beta-hydroxysteroid dehydrogenase and steroid 21-hydroxylase P450c21, which catalyze the intermediate steps for syntheses of both aldosterone and corticosterone, were inducible in the three cell lines in temperature- and/or dibutyryl cAMP-dependent manners.	Corticosterone	163-177	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	55-77
11744998-9	2002	Conversely, at days 2 and 4 of treatment the blood concentration of corticosterone was lower in leptin-infused than in control rats, which at these times displayed elevated levels of circulating corticosterone.	Corticosterone	68-82	leptin	Rattus norvegicus	96-102
11744998-9	2002	Conversely, at days 2 and 4 of treatment the blood concentration of corticosterone was lower in leptin-infused than in control rats, which at these times displayed elevated levels of circulating corticosterone.	Corticosterone	195-209	leptin	Rattus norvegicus	96-102
11744998-10	2002	Taken together, these findings allow us to conclude that in the rat the prolonged infusion of low doses of leptin i) primarily depresses pituitary ACTH production, the effect being probably mediated by the hypothalamus; and ii) inhibits corticosterone response to the stress evoked by placing of animals in the metabolic cages.	Corticosterone	237-251	leptin	Rattus norvegicus	107-113
11891848-6	2002	H89, an inhibitor of protein kinase A (PKA), decreased the production of corticosterone in ZFR cells from young but not old Ovx rats.	Corticosterone	73-87	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	21-37
11891848-6	2002	H89, an inhibitor of protein kinase A (PKA), decreased the production of corticosterone in ZFR cells from young but not old Ovx rats.	Corticosterone	73-87	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	39-42
11891848-10	2002	These results suggest that aging increases corticosterone production in Ovx rats via a mechanism in part associated with an increase of adenylyl cyclase activity and a decrease of phosphodiesterase activity, and then an increase of the generation of cAMP, but not related to either PKA activity or 11 beta-hydroxylase.	Corticosterone	43-57	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	282-285
11903813-7	2002	This reduction of the pressor response to angiotensin II could be reversed and even further enhanced by replacement of the ADX rats with high corticosterone concentrations.	Corticosterone	142-156	angiotensinogen	Rattus norvegicus	42-56
12139394-7	2002	Moreover, Z-100 decreased the corticosterone levels, which is known to suppress the Th1 cell responses, in both serum specimens and splenic tissue, and the steroidogenic CYP11A1 mRNA expression in CD4+ T cells.	Corticosterone	30-44	negative elongation factor complex member C/D, Th1l	Mus musculus	84-87
11751036-3	2002	In addition, plasma ACTH and corticosterone responses to subsequent CRH (7:30 P.M.; 50 ng/kg) were significantly higher in male HAB rats.	Corticosterone	29-43	corticotropin releasing hormone	Rattus norvegicus	68-71
12907841-6	2002	Plasma corticosterone (CORT) rose from basal levels of 99 to 831 nmol/l in knockout mice upon IL-1beta stimulation, whereas in wild-type mice CORT levels rose from 112 to 841 nmol/l.	Corticosterone	7-21	interleukin 1 beta	Mus musculus	94-102
12907841-6	2002	Plasma corticosterone (CORT) rose from basal levels of 99 to 831 nmol/l in knockout mice upon IL-1beta stimulation, whereas in wild-type mice CORT levels rose from 112 to 841 nmol/l.	Corticosterone	23-27	interleukin 1 beta	Mus musculus	94-102
12207954-7	2002	The neurotrophic effect of corticosterone and kainic acid was attenuated by the receptor tyrosine kinase A (TrkA) inhibitor AG-879.	Corticosterone	27-41	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	108-112
12207954-8	2002	Western blot analysis and immunocytochemical studies revealed an increase of expressions of both TrkA and growth-associated protein GAP-43 in dorsal root ganglion neurons with combined treatment of corticosterone and kainic acid.	Corticosterone	198-212	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	97-101
12207954-8	2002	Western blot analysis and immunocytochemical studies revealed an increase of expressions of both TrkA and growth-associated protein GAP-43 in dorsal root ganglion neurons with combined treatment of corticosterone and kainic acid.	Corticosterone	198-212	growth associated protein 43	Rattus norvegicus	132-138
12207954-9	2002	Immunocytochemistry showed that corticosterone+kainic acid increase nerve growth factor immunoreactivity in dorsal root ganglion neurites and enhance GAP-43 immunointensity in dorsal root ganglion neurons.	Corticosterone	32-46	growth associated protein 43	Rattus norvegicus	150-156
12421628-0	2002	Orphanin FQ-induced hyperphagia is mediated by corticosterone and central glucocorticoid receptors.	Corticosterone	47-61	prepronociceptin	Rattus norvegicus	0-11
12421628-1	2002	Orphanin FQ (Nociceptin) has been reported to stimulate food intake in satiated rats and to stimulate corticosterone release.	Corticosterone	102-116	prepronociceptin	Rattus norvegicus	0-11
12421628-1	2002	Orphanin FQ (Nociceptin) has been reported to stimulate food intake in satiated rats and to stimulate corticosterone release.	Corticosterone	102-116	prepronociceptin	Rattus norvegicus	13-23
12421628-4	2002	We found that intracerebroventricular injection of Orphanin FQ (0.64-5 nmoles) dose dependently stimulated food intake and plasma corticosterone within 30 min of injection.	Corticosterone	130-144	prepronociceptin	Rattus norvegicus	51-62
12421628-5	2002	Removal of corticosterone, by adrenalectomy, abolished the hyperphagic effect of Orphanin FQ.	Corticosterone	11-25	prepronociceptin	Rattus norvegicus	81-92
12421628-6	2002	The stimulatory effect of Orphanin FQ on food intake was still negated following a low dose of corticosterone replacement (corresponding to a plasma corticosterone concentration of 1.86+/-0.99 microg/dl).	Corticosterone	95-109	prepronociceptin	Rattus norvegicus	26-37
12421628-6	2002	The stimulatory effect of Orphanin FQ on food intake was still negated following a low dose of corticosterone replacement (corresponding to a plasma corticosterone concentration of 1.86+/-0.99 microg/dl).	Corticosterone	149-163	prepronociceptin	Rattus norvegicus	26-37
12421628-10	2002	Overall, these data demonstrate the necessity for circulating corticosterone in the mediation of Orphanin-FQ-induced feeding and suggest that the mechanism through which the hyperphagic effect is obtained involves activation of central glucocorticoid receptors.	Corticosterone	62-76	prepronociceptin	Rattus norvegicus	97-108
11738809-8	2001	In the mouse, chronic NPY infusion induced a sustained increase in corticosterone and insulin secretion.	Corticosterone	67-81	neuropeptide Y	Mus musculus	22-25
11849373-9	2002	These data suggest that in PM rats, an elevation of basal concentrations of corticosterone, in face of reduced CBG and probably increased hippocampal MR lead to a much larger impact of corticosterone on target cells that mediate the negative-feedback mechanism on the activities of both the HPA axis and sympathoadrenal one.	Corticosterone	76-90	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	150-152
11903416-2	2001	h-leptin and m-leptin on body weight and plasma corticosterone are due to reduced food intake.	Corticosterone	48-62	leptin	Rattus norvegicus	2-8
11903416-2	2001	h-leptin and m-leptin on body weight and plasma corticosterone are due to reduced food intake.	Corticosterone	48-62	leptin	Rattus norvegicus	15-21
11903416-10	2001	Further, both m-leptin and h-leptin infusions in lean rats elevated terminal plasma corticosterone (352 +/- 37 and 389 +/- 55 ng/ml, respectively) to levels similar to those in i.c.v.	Corticosterone	84-98	leptin	Rattus norvegicus	16-22
11903416-10	2001	Further, both m-leptin and h-leptin infusions in lean rats elevated terminal plasma corticosterone (352 +/- 37 and 389 +/- 55 ng/ml, respectively) to levels similar to those in i.c.v.	Corticosterone	84-98	leptin	Rattus norvegicus	29-35
11903416-12	2001	The increase in plasma corticosterone level coincided with the maximum hypophagic effects of leptin and preceded the appearance and sustained elevation of exogenous human leptin in the circulation.	Corticosterone	23-37	leptin	Homo sapiens	93-99
11903416-12	2001	The increase in plasma corticosterone level coincided with the maximum hypophagic effects of leptin and preceded the appearance and sustained elevation of exogenous human leptin in the circulation.	Corticosterone	23-37	leptin	Homo sapiens	171-177
11903416-18	2001	Furthermore, m-leptin and h-leptin elevated plasma corticosterone levels and h-leptin caused some weight loss in lean rats independently of its suppression of food intake.	Corticosterone	51-65	leptin	Rattus norvegicus	15-21
11903416-18	2001	Furthermore, m-leptin and h-leptin elevated plasma corticosterone levels and h-leptin caused some weight loss in lean rats independently of its suppression of food intake.	Corticosterone	51-65	leptin	Rattus norvegicus	28-34
11903416-18	2001	Furthermore, m-leptin and h-leptin elevated plasma corticosterone levels and h-leptin caused some weight loss in lean rats independently of its suppression of food intake.	Corticosterone	51-65	leptin	Rattus norvegicus	28-34
11903416-19	2001	The elevation of corticosterone levels in the lean rats may be a mechanism whereby they resist excessive weight loss in response to leptin.	Corticosterone	17-31	leptin	Rattus norvegicus	132-138
11849373-9	2002	These data suggest that in PM rats, an elevation of basal concentrations of corticosterone, in face of reduced CBG and probably increased hippocampal MR lead to a much larger impact of corticosterone on target cells that mediate the negative-feedback mechanism on the activities of both the HPA axis and sympathoadrenal one.	Corticosterone	185-199	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	150-152
11785774-0	2001	Involvement of constitutive (COX-1) and inducible cyclooxygenase (COX-2) in the adrenergic-induced ACTH and corticosterone secretion.	Corticosterone	108-122	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	29-34
12018519-2	2001	GnRH antagonist treated rats fed on 20% casein diet, resulted significant decrease in adrenal weight, serum corticosterone and adrenal A5-3beta-HSD activity while testicular 17beta-HSD activity serum testosterone levels and the weights of sex organs were increased with respect to anti GnRH treated rats fed on 5% casein diet.	Corticosterone	108-122	gonadotropin releasing hormone 1	Rattus norvegicus	0-4
11713467-1	2001	There is evidence that in rats, partial hippocampal lesions or selective ablation of the CA3 subfield can disrupt retrieval of spatial memory and that hippocampal damage disinhibits hypothalamic-pituitary-adrenocortical (HPA)-axis activity, thereby elevating plasma levels of adrenocorticotropin and corticosterone.	Corticosterone	300-314	carbonic anhydrase 3	Rattus norvegicus	89-92
11713467-2	2001	Here we report evidence that attenuation of CA3 lesion-induced increases in circulating corticosterone levels with the synthesis inhibitor metyrapone, administered shortly before water-maze retention testing, blocks the impairing effects of the lesion on memory retrieval.	Corticosterone	88-102	carbonic anhydrase 3	Rattus norvegicus	44-47
11785774-0	2001	Involvement of constitutive (COX-1) and inducible cyclooxygenase (COX-2) in the adrenergic-induced ACTH and corticosterone secretion.	Corticosterone	108-122	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	66-71
11930228-1	2001	Experiments were carried out to study the toxic effect of corticosterone (CORT) on primary cultured hippocampal cells and its relationship with mitochondrial membrane potential (MMP).	Corticosterone	58-72	cortistatin	Homo sapiens	74-78
11930217-0	2001	Rapid activation of p38 mitogen-activated protein kinase by corticosterone in PC12 cells.	Corticosterone	60-74	mitogen activated protein kinase 14	Rattus norvegicus	20-23
11930217-1	2001	The present study using immunoblot showed that corticosterone (B) could induce a rapid activation of p38 in PC12 cells.	Corticosterone	47-61	mitogen activated protein kinase 14	Rattus norvegicus	101-104
11745662-20	2001	Opposite effects on NCAM expression in the rat frontal cortex induced by acute vs. chronic corticosterone treatments.	Corticosterone	91-105	neural cell adhesion molecule 1	Rattus norvegicus	20-24
11711207-1	2001	Plasma corticosterone (CORT) levels were measured after short periods of sleep deprivation in rats at postnatal days 12, 16, 20, and 24.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
11744090-5	2001	Treatments with corticosterone or dexamethasone up-regulate FGF-2 expression in different rat brain regions as well as in cultured astroglial cells.	Corticosterone	16-30	fibroblast growth factor 2	Rattus norvegicus	60-65
11744090-8	2001	Moreover exposure to corticosterone during late stage of embryonic life (E18-E20) produces a significant reduction of FGF-2 mRNA levels in the adult hippocampus of male rats as well as changes in its acute modulation in response to stress or corticosterone.	Corticosterone	21-35	fibroblast growth factor 2	Rattus norvegicus	118-123
11722612-0	2001	Stress alleviates reduced expression of cell adhesion molecules (NCAM, L1), and deficits in learning and corticosterone regulation of apolipoprotein E knockout mice.	Corticosterone	105-119	apolipoprotein E	Mus musculus	134-150
11597906-4	2001	Leptin elevation could not be attributed to changes in circulating tumor necrosis factor-alpha but was completely dependent on endogenous corticosterone elevation because adrenalectomized mice did not exhibit any increase in leptin levels.	Corticosterone	138-152	leptin	Mus musculus	0-6
11606459-2	2001	This corticosterone secretion is thought to be controlled by a circadian clock in the suprachiasmatic nucleus (SCN).	Corticosterone	5-19	circadian locomotor output cycles kaput	Mus musculus	73-78
11606459-8	2001	The present study suggests that a stress-induced disturbance of circadian corticosterone secretion may be associated with the stress-induced expression of mPer1 mRNA in the PVN.	Corticosterone	74-88	period circadian clock 1	Mus musculus	155-160
11606463-7	2001	Within the intraadrenal CRH/ACTH system, our data suggest different roles for CRHR1 and CRHR2 in fine-tuning of adrenocortical corticosterone release.	Corticosterone	127-141	corticotropin releasing hormone	Mus musculus	24-27
11606463-7	2001	Within the intraadrenal CRH/ACTH system, our data suggest different roles for CRHR1 and CRHR2 in fine-tuning of adrenocortical corticosterone release.	Corticosterone	127-141	pro-opiomelanocortin-alpha	Mus musculus	28-32
11606463-7	2001	Within the intraadrenal CRH/ACTH system, our data suggest different roles for CRHR1 and CRHR2 in fine-tuning of adrenocortical corticosterone release.	Corticosterone	127-141	corticotropin releasing hormone receptor 1	Mus musculus	78-83
11606463-7	2001	Within the intraadrenal CRH/ACTH system, our data suggest different roles for CRHR1 and CRHR2 in fine-tuning of adrenocortical corticosterone release.	Corticosterone	127-141	corticotropin releasing hormone receptor 2	Mus musculus	88-93
11765048-5	2001	The corticosterone response was significantly reduced in IL-6 -/- mice, but no differences in TNFalpha or in IL-1alpha plasma levels were found between the two strains.	Corticosterone	4-18	interleukin 6	Mus musculus	57-61
11860476-1	2001	Long-term potentiation (LTP) in both area CA1 and the dentate gyrus is attenuated by stress and the evidence is consistent with the view that this is a consequence of increased activation of glucocorticoid receptors, in the hippocampus, following the stress-induced increase in circulating corticosterone.	Corticosterone	290-304	carbonic anhydrase 1	Rattus norvegicus	42-45
11887933-6	2001	In vitro the selective COX-2 inhibitor SC-236 caused a marked reduction in adrenocorticotropic hormone-driven corticosterone release, as did the nonselective COX inhibitor, indomethacin.	Corticosterone	110-124	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	23-28
11606764-10	2001	These findings suggest that task-related facilitating effects of corticosterone on spatial memory indeed depend on DNA binding of the glucocorticoid receptor rather than on protein-protein interactions of the receptor with other transcription factors.	Corticosterone	65-79	nuclear receptor subfamily 3, group C, member 1	Mus musculus	134-157
11693261-4	2001	Since hepatic 11beta-HSD1 in vivo mainly functions as 11-keto-reductase and does not work as 11beta-oxidase, these results suggest that the rate of hepatic conversion of 11-dehydrocorticosterone to corticosterone is increased in db/db mice, resulting in higher glucocorticoid activity in the liver.	Corticosterone	180-194	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	14-25
11693261-5	2001	The increased hepatic corticosterone concentration due to the elevation of 11beta-HSD1 and high plasma corticosterone concentration may antagonize the action of insulin and cause insulin resistance.	Corticosterone	22-36	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	75-86
11573966-0	2001	Rapid activation of ERK1/2 mitogen-activated protein kinase by corticosterone in PC12 cells.	Corticosterone	63-77	mitogen activated protein kinase 3	Rattus norvegicus	20-26
11573966-2	2001	The present study using Western immunoblot and protein kinase activity assay, for the first time, showed that corticosterone (B) can induce a rapid activation of Erk1/2 mitogen-activated protein kinase (MAPK) in PC12 cells.	Corticosterone	110-124	mitogen activated protein kinase 3	Rattus norvegicus	162-168
11675041-0	2001	Ketanserin attenuates the behavioural effects of corticosterone: implications for 5-HT(2A) receptor regulation.	Corticosterone	49-63	5-hydroxytryptamine receptor 2A	Canis lupus familiaris	82-89
11675041-6	2001	Results suggest that increased 5-HT(2A) receptor activity mediates the effects of corticosterone on sexual behaviour and wet-dog shakes.	Corticosterone	82-96	5-hydroxytryptamine receptor 2A	Canis lupus familiaris	31-48
11551859-1	2001	The aim of the present study was to assess whether the glucocorticoid corticosterone (Cort) modulates the effects of leptin on food intake and lipid deposition.	Corticosterone	70-84	leptin	Rattus norvegicus	117-123
11551859-1	2001	The aim of the present study was to assess whether the glucocorticoid corticosterone (Cort) modulates the effects of leptin on food intake and lipid deposition.	Corticosterone	86-90	leptin	Rattus norvegicus	117-123
11551859-10	2001	The study demonstrates that, whereas the anorectic effect of leptin is dampened by high but physiological plasma levels of corticosterone, leptin can produce its effects on body weight, lipid transport and accumulation, and adipose and muscle LPL activity in the absence or presence of an intact hypothalamic-pituitary-adrenal axis.	Corticosterone	123-137	leptin	Rattus norvegicus	61-67
11588113-16	2001	significantly increased the plasma corticosterone level, and these effects of 5-HT(1A) receptor agonists were dose-dependently blocked by pretreatment with metyrapone (12.5 and 25 mg kg(-1), s.c.).	Corticosterone	35-49	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	78-95
11606330-11	2001	Corticosterone did not affect the resting plasma corticotrophin (ACTH) concentration but suppressed the hypersecretion of ACTH induced by IL-1beta (i.p.	Corticosterone	0-14	interleukin 1 beta	Rattus norvegicus	138-146
11606330-15	2001	By contrast, corticosterone provoked an increase in serum growth hormone (GH) which was ablated by central but not peripheral administration of anti-annexin 1 pAb.	Corticosterone	13-27	gonadotropin releasing hormone receptor	Rattus norvegicus	58-72
11606330-15	2001	By contrast, corticosterone provoked an increase in serum growth hormone (GH) which was ablated by central but not peripheral administration of anti-annexin 1 pAb.	Corticosterone	13-27	gonadotropin releasing hormone receptor	Rattus norvegicus	74-76
11606330-18	2001	did not affect basal GH but, when given centrally but not peripherally, it abolished the corticosterone-induced hypersecretion of GH.	Corticosterone	89-103	gonadotropin releasing hormone receptor	Rattus norvegicus	130-132
11860185-8	2001	Corticosterone administration for 3 days markedly decreased CRH mRNA t1/2 in both sham-operated and adrenalectomized rats (6.5 and 5.0 min, respectively).	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	60-63
11600545-10	2001	However, it is known that both orexin-A and orexin-B can induce corticosterone production in dispersed rat adrenocortical cells.	Corticosterone	64-78	hypocretin neuropeptide precursor	Rattus norvegicus	31-39
11600545-10	2001	However, it is known that both orexin-A and orexin-B can induce corticosterone production in dispersed rat adrenocortical cells.	Corticosterone	64-78	hypocretin neuropeptide precursor	Homo sapiens	31-37
11602618-5	2001	The obese mice with low levels of hypothalamic ObR also show elevated plasma levels of leptin, glucose, insulin, and corticosterone.	Corticosterone	117-131	leptin receptor	Mus musculus	47-50
11679056-6	2001	Furthermore, acutely withdrawn rats displayed reduced ACTH but prolonged corticosterone responses to peripheral corticotropin releasing hormone (CRH) administration.	Corticosterone	73-87	corticotropin releasing hormone	Rattus norvegicus	112-143
11679056-6	2001	Furthermore, acutely withdrawn rats displayed reduced ACTH but prolonged corticosterone responses to peripheral corticotropin releasing hormone (CRH) administration.	Corticosterone	73-87	corticotropin releasing hormone	Rattus norvegicus	145-148
11553785-9	2001	Thus, enhanced bcl-2 expression offsets the potentially deleterious consequences of high postischemic plasma corticosterone concentrations.	Corticosterone	109-123	B cell leukemia/lymphoma 2	Mus musculus	15-20
11557088-3	2001	It is, therefore, hypothesized that early environment-induced changes in receptor sensitivity to corticosterone (CORT) might have functional effects on adult neuronal excitability and synaptic plasticity.	Corticosterone	97-111	cortistatin	Rattus norvegicus	113-117
11588595-6	2001	These results indicate that a moderate increase of corticosterone in the lactating mother modulates NGF in the developing rat.	Corticosterone	51-65	nerve growth factor	Rattus norvegicus	100-103
11502595-6	2001	Mepiperphenidol and O-methylisoprenaline showed an approximately 70-fold lower and corticosterone a 38-fold higher affinity for rOCT2.	Corticosterone	83-97	solute carrier family 22 member 2	Rattus norvegicus	128-133
11507018-9	2001	However, the low glucose concentrations resulting from exogenous insulin returned to basal quicker with exogenous corticosterone but only during the day.	Corticosterone	114-128	insulin	Sturnus vulgaris	65-72
11532864-7	2001	Adrenalectomy and CCS supplementation demonstrated that the effects of DER on AP-1-DNA binding were mediated in part by CCS.	Corticosterone	18-21	jun proto-oncogene	Mus musculus	78-82
11532864-7	2001	Adrenalectomy and CCS supplementation demonstrated that the effects of DER on AP-1-DNA binding were mediated in part by CCS.	Corticosterone	120-123	jun proto-oncogene	Mus musculus	78-82
11517194-2	2001	Most recently, we could show that severe emotional stressors induce a significant rise in plasma ACTH even in mice deficient for the CRHR1 (Crhr1-1-) which is, however, not accompanied by an increase in plasma corticosterone concentration, suggesting that CRHR1 might be directly involved in the regulation of adrenal corticosterone release.	Corticosterone	318-332	corticotropin releasing hormone receptor 1	Mus musculus	133-138
11517194-7	2001	Our data strongly suggest that CRHR1 plays a crucial role in the release of corticosterone from the adrenal cortex, independently of pituitary function.	Corticosterone	76-90	corticotropin releasing hormone receptor 1	Mus musculus	31-36
11549669-6	2001	18-Hydroxydeoxycorticosterone significantly reduced the conversion rate of 11-deoxycorticosterone to corticosterone and that of 11-deoxycortisol to cortisol by both enzymes, but the production rate of 18- hydroxycorticosterone and aldosterone by aldosterone synthase increased.	Corticosterone	15-29	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	246-266
11549701-3	2001	Moreover, in a rodent model administration of orexin A induced corticosterone production.	Corticosterone	63-77	hypocretin neuropeptide precursor	Homo sapiens	46-52
11565606-8	2001	Circulating corticosterone (CORT), an endogenous glucocorticoid with significant effects on lymphocyte phenotype and function, was elevated within 24 h after spinal cord injury (SCI) and remained above control levels throughout the duration of our studies (up to 1 month postinjury).	Corticosterone	12-26	cortistatin	Homo sapiens	28-32
11545618-3	2001	The secretion of GH from the selected transformants was dose-dependently augmented by the application of hydrocortisone, corticosterone, or dexamethasone, among which dexamethasone was the most potent.	Corticosterone	121-135	growth hormone 1	Homo sapiens	17-19
11528215-8	2001	Furthermore, intraperitoneal injection of ghrelin produced a significant dose- dependent increase in serum corticosterone levels.	Corticosterone	107-121	ghrelin	Mus musculus	42-49
11498262-2	2001	In this study, chronic morphine was shown to suppress IL-1beta-induction of corticotropin releasing factor (CRF) mRNA and plasma corticosterone levels.	Corticosterone	129-143	interleukin 1 beta	Rattus norvegicus	54-62
11440909-6	2001	Corticosterone response to stress was increased in the IL-6 group (P &lt; 0.05-0.01).	Corticosterone	0-14	interleukin 6	Rattus norvegicus	55-59
11459800-8	2001	Exogenous administration of corticosterone in vivo or acute restraint stress also reduces cardiac CRH receptor type 2 mRNA expression, but like cytokines, in vitro corticosterone treatment does not modulate expression in cardiomyocytes.	Corticosterone	28-42	corticotropin releasing hormone	Mus musculus	98-101
11762707-2	2001	We addressed the hypothesis that corticosterone regulates the expression of the apoptotic bcl-2 gene family.	Corticosterone	33-47	BCL2, apoptosis regulator	Rattus norvegicus	90-95
11762707-5	2001	Using RT-PCR we found a reduction in mRNA levels of the antiapoptotic gene bcl-2 in whole hippocampus, an effect which was prevented by corticosterone administration to ADX rats.	Corticosterone	136-150	BCL2, apoptosis regulator	Rattus norvegicus	75-80
11762707-8	2001	In contrast, we found a reduction in the mRNA of the antiapoptotic gene bax and Bax levels after ADX; both effects were prevented by corticosterone.	Corticosterone	133-147	BCL2 associated X, apoptosis regulator	Rattus norvegicus	72-75
11576624-1	2001	The 11beta-hydroxysteroid dehydrogenase types 1 and 2 enzymes (11beta-HSD1 and 11beta-HSD2), modulate glucocorticoid occupation of the mineralocorticoid and glucocorticoid receptors by interconverting corticosterone and cortisol to the inactive metabolites 11-dehydrocorticosterone and cortisone within the target cells.	Corticosterone	201-215	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	63-74
11576624-1	2001	The 11beta-hydroxysteroid dehydrogenase types 1 and 2 enzymes (11beta-HSD1 and 11beta-HSD2), modulate glucocorticoid occupation of the mineralocorticoid and glucocorticoid receptors by interconverting corticosterone and cortisol to the inactive metabolites 11-dehydrocorticosterone and cortisone within the target cells.	Corticosterone	201-215	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	79-90
11579225-0	2001	Homology modelling of the ligand-binding domain of glucocorticoid receptor: binding site interactions with cortisol and corticosterone.	Corticosterone	120-134	nuclear receptor subfamily 3, group C, member 1	Mus musculus	51-74
11430862-2	2001	Inasmuch as corticotropin-releasing hormone (CRH) and bombesin (BN) have been associated with anxiety, regional levels and release of these peptides, as well as plasma adrenocorticotropic hormone (ACTH) and corticosterone, were assessed in "Slow" and "Fast" seizing rats following predator exposure (ferret) or immobilization.	Corticosterone	207-221	corticotropin releasing hormone	Rattus norvegicus	45-48
11516573-0	2001	High-voltage-activated Ca2+ currents and the excitability of pyramidal neurons in the hippocampal CA3 subfield in rats depend on corticosterone and time of day.	Corticosterone	129-143	carbonic anhydrase 2	Rattus norvegicus	23-26
11516573-0	2001	High-voltage-activated Ca2+ currents and the excitability of pyramidal neurons in the hippocampal CA3 subfield in rats depend on corticosterone and time of day.	Corticosterone	129-143	carbonic anhydrase 3	Rattus norvegicus	98-101
11516573-4	2001	Over the entire time range, the amplitude of the Ca2+ current correlated with plasma corticosterone levels in a U-shaped function.	Corticosterone	85-99	carbonic anhydrase 2	Rattus norvegicus	49-52
11515530-10	2001	These results suggest that feeding oleic acid to rats exposed to water-immersion restraint further accelerated liver glycogen synthesis through the rise in liver SDH activity due to increased corticosterone secretion when compared with the effect from linoleic and alpha-linolenic acids.	Corticosterone	192-206	serine dehydratase	Rattus norvegicus	162-165
11507677-8	2001	Fatty acids may increase the affinity of CBG for corticosterone, which would make WAT cells less accessible to circulating glucocorticoids.	Corticosterone	49-63	serpin family A member 6	Rattus norvegicus	41-44
11510960-5	2001	Orexin-A increased corticosterone plasma concentration in immature rats, but not in animals with regenerating adrenals.	Corticosterone	19-33	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
11425909-5	2001	Radioligand binding assays showed that corticotropin-releasing hormone (CRH) injected intracerebroventricularly into adrenalectomized rats also produced a rise in hippocampal MR levels; an effect for which the presence of corticosterone, but not dexamethasone, at the time of injection was a prerequisite.	Corticosterone	222-236	corticotropin releasing hormone	Rattus norvegicus	39-70
11425909-5	2001	Radioligand binding assays showed that corticotropin-releasing hormone (CRH) injected intracerebroventricularly into adrenalectomized rats also produced a rise in hippocampal MR levels; an effect for which the presence of corticosterone, but not dexamethasone, at the time of injection was a prerequisite.	Corticosterone	222-236	corticotropin releasing hormone	Rattus norvegicus	72-75
11425909-5	2001	Radioligand binding assays showed that corticotropin-releasing hormone (CRH) injected intracerebroventricularly into adrenalectomized rats also produced a rise in hippocampal MR levels; an effect for which the presence of corticosterone, but not dexamethasone, at the time of injection was a prerequisite.	Corticosterone	222-236	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	175-177
11442777-7	2001	Corticosterone implants near CeA decreased the weight of fat depots only in cold; corticosterone implants in prefrontal cortex were ineffective.	Corticosterone	0-14	carcinoembryonic antigen gene family 4	Rattus norvegicus	29-32
11442777-8	2001	We conclude that (i) corticosterone inhibits insulin and ACTH secretion by an action in prefrontal cortex but not CeA; (ii) high concentrations of corticosterone secreted during chronic stress alter metabolism through (autonomic) outputs of the CeA and prefrontal cortex in site- and variable-specific fashion; and (iii) the amygdala is a component of a stress-recruited, state-dependent pathway.	Corticosterone	21-35	carcinoembryonic antigen gene family 4	Rattus norvegicus	245-248
11442777-8	2001	We conclude that (i) corticosterone inhibits insulin and ACTH secretion by an action in prefrontal cortex but not CeA; (ii) high concentrations of corticosterone secreted during chronic stress alter metabolism through (autonomic) outputs of the CeA and prefrontal cortex in site- and variable-specific fashion; and (iii) the amygdala is a component of a stress-recruited, state-dependent pathway.	Corticosterone	147-161	carcinoembryonic antigen gene family 4	Rattus norvegicus	245-248
11435609-4	2001	Corticosterone (CORT) induced a rapid nuclear accumulation of GFP-MR, whereas in the absence of ligand, GFP-MR was distributed in both cytoplasm and nucleus in the majority of transfected cells.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
11435609-4	2001	Corticosterone (CORT) induced a rapid nuclear accumulation of GFP-MR, whereas in the absence of ligand, GFP-MR was distributed in both cytoplasm and nucleus in the majority of transfected cells.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	62-68
11443536-6	2001	All animals tested exhibited elevated corticosterone levels when stressed, an indication, that in cLH rats regulation of BDNF expression in the hippocampal formation is uncoupled from corticosterone increase induced through stress.	Corticosterone	38-52	brain-derived neurotrophic factor	Rattus norvegicus	121-125
11509225-1	2001	Recent findings have demonstrated that Fawn hooded (FH/Har) rats exhibit enhanced plasma corticosterone (CORT) responses compared to Wistar rats after exposure to an open field, whereas this effect was not influenced by early social experience.	Corticosterone	89-103	cortistatin	Rattus norvegicus	105-109
11337130-5	2001	In the acutely (one-time) stressed rats, the basal plasma corticosterone (CORT) level was markedly elevated, remained at high levels for 5 h after the termination of stress, and then decreased.	Corticosterone	58-72	cortistatin	Rattus norvegicus	74-78
11410728-2	2001	Possible mechanisms mediating this alteration in HPA responsiveness include stress-associated changes in corticosterone (CORT) feedback signals, alterations in CORT signals under basal conditions, and CORT-independent mechanisms.	Corticosterone	105-119	cortistatin	Rattus norvegicus	121-125
11353676-5	2001	Microinjection of ANG II intracerebroventricularly produced a significantly larger increase in AP in Cort-treated rats than in control rats.	Corticosterone	101-105	angiotensinogen	Rattus norvegicus	18-24
11422117-10	2001	Basal concentrations of DOC, corticosterone, 11-deoxycortisol and cortisol and responses of corticosterone and cortisol to ACTH were not affected by genotype.	Corticosterone	92-106	proopiomelanocortin	Homo sapiens	123-127
11356720-1	2001	In the present study, we investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in the control of access of cortisol and corticosterone to the mouse and human brain.	Corticosterone	170-184	phosphoglycolate phosphatase	Mus musculus	81-95
11356720-1	2001	In the present study, we investigated the role of the multidrug resistance (mdr) P-glycoprotein (Pgp) at the blood-brain barrier in the control of access of cortisol and corticosterone to the mouse and human brain.	Corticosterone	170-184	phosphoglycolate phosphatase	Mus musculus	97-100
11356720-4	2001	Interestingly, human MDR1 Pgp also differentially transported cortisol and corticosterone.	Corticosterone	75-89	ATP binding cassette subfamily B member 1	Homo sapiens	21-25
11356720-4	2001	Interestingly, human MDR1 Pgp also differentially transported cortisol and corticosterone.	Corticosterone	75-89	phosphoglycolate phosphatase	Homo sapiens	26-29
11356720-5	2001	LLC-PK1 monolayers stably transfected with MDR1 complementary DNA showed polar transport of [(3)H]cortisol that could be blocked by a specific Pgp blocker, whereas [(3)H]corticosterone transport did not differ between transfected and host cells.	Corticosterone	170-184	ATP binding cassette subfamily B member 1	Homo sapiens	43-47
11395925-12	2001	Corticosterone levels in stressed GHR-KO females were similar to those measured in stressed normal females.	Corticosterone	0-14	growth hormone receptor	Mus musculus	34-37
11360298-6	2001	There was a dramatic decrease of cell proliferation in the DG from both the aged rats and the corticosterone-treated adult rats that was correlated with a decreased expression of vimentin by the astrocytes present in this region.	Corticosterone	94-108	vimentin	Rattus norvegicus	179-187
11375120-3	2001	In this study, the time course of corticosterone induction of GH-secreting cells in cultures of chicken embryonic pituitary cells, responsiveness of differentiated somatotrophs to GH secretagogues, localization of somatotroph precursor cells within the pituitary gland, and the effect of corticosterone on GH gene expression were determined to better define the involvement of glucocorticoids in somatotroph recruitment during development.	Corticosterone	34-48	growth hormone	Gallus gallus	62-64
11375120-5	2001	Corticosterone treatment for as short as 16 h increased the percentage of GH cells compared with the control.	Corticosterone	0-14	growth hormone	Gallus gallus	74-76
11375120-6	2001	When corticosterone was removed after 48 h and cells were cultured for an additional 3 days in medium alone, the percentage of GH secretors decreased but remained greater than the proportion of somatotrophs among cells that were never treated with corticosterone.	Corticosterone	5-19	growth hormone	Gallus gallus	127-129
11375120-8	2001	Approximately half of the somatotrophs induced to differentiate with corticosterone subsequently released more GH in response to GHRH and TRH than in their absence.	Corticosterone	69-83	growth hormone	Gallus gallus	111-113
11375120-8	2001	Approximately half of the somatotrophs induced to differentiate with corticosterone subsequently released more GH in response to GHRH and TRH than in their absence.	Corticosterone	69-83	growth hormone releasing hormone	Gallus gallus	129-133
11375120-8	2001	Approximately half of the somatotrophs induced to differentiate with corticosterone subsequently released more GH in response to GHRH and TRH than in their absence.	Corticosterone	69-83	thyrotropin releasing hormone	Gallus gallus	138-141
11375120-10	2001	Corticosterone induction of GH cells was substantially greater in cultures derived from the caudal lobe of the anterior pituitary, where somatotroph differentiation normally occurs.	Corticosterone	0-14	growth hormone	Gallus gallus	28-30
11375120-12	2001	Corticosterone increased GH mRNA in cultured cells by greater than fourfold.	Corticosterone	0-14	growth hormone	Gallus gallus	25-27
11375120-13	2001	Moreover, corticosterone-induced somatotroph differentiation involved GH gene expression in cells not expressing GH mRNA previously, and the extent of somatotroph differentiation was augmented by treatment with GHRH in combination with corticosterone.	Corticosterone	10-24	growth hormone	Gallus gallus	70-72
11375120-13	2001	Moreover, corticosterone-induced somatotroph differentiation involved GH gene expression in cells not expressing GH mRNA previously, and the extent of somatotroph differentiation was augmented by treatment with GHRH in combination with corticosterone.	Corticosterone	10-24	growth hormone	Gallus gallus	113-115
11375120-13	2001	Moreover, corticosterone-induced somatotroph differentiation involved GH gene expression in cells not expressing GH mRNA previously, and the extent of somatotroph differentiation was augmented by treatment with GHRH in combination with corticosterone.	Corticosterone	10-24	growth hormone releasing hormone	Gallus gallus	211-215
11375120-13	2001	Moreover, corticosterone-induced somatotroph differentiation involved GH gene expression in cells not expressing GH mRNA previously, and the extent of somatotroph differentiation was augmented by treatment with GHRH in combination with corticosterone.	Corticosterone	236-250	growth hormone	Gallus gallus	70-72
11375120-14	2001	We conclude that corticosterone increases the number of GH-secreting cells within 16 h, increases GH gene expression in cells formerly not expressing this gene, confers somatotroph sensitivity to GHRH and TRH, and induces GH production in a precursor population found primarily in the caudal lobe of the anterior pituitary, a site consistent with GH localization in adults.	Corticosterone	17-31	growth hormone	Gallus gallus	56-58
11375120-14	2001	We conclude that corticosterone increases the number of GH-secreting cells within 16 h, increases GH gene expression in cells formerly not expressing this gene, confers somatotroph sensitivity to GHRH and TRH, and induces GH production in a precursor population found primarily in the caudal lobe of the anterior pituitary, a site consistent with GH localization in adults.	Corticosterone	17-31	growth hormone	Gallus gallus	98-100
11375120-14	2001	We conclude that corticosterone increases the number of GH-secreting cells within 16 h, increases GH gene expression in cells formerly not expressing this gene, confers somatotroph sensitivity to GHRH and TRH, and induces GH production in a precursor population found primarily in the caudal lobe of the anterior pituitary, a site consistent with GH localization in adults.	Corticosterone	17-31	growth hormone releasing hormone	Gallus gallus	196-200
11375120-14	2001	We conclude that corticosterone increases the number of GH-secreting cells within 16 h, increases GH gene expression in cells formerly not expressing this gene, confers somatotroph sensitivity to GHRH and TRH, and induces GH production in a precursor population found primarily in the caudal lobe of the anterior pituitary, a site consistent with GH localization in adults.	Corticosterone	17-31	thyrotropin releasing hormone	Gallus gallus	205-208
11375120-14	2001	We conclude that corticosterone increases the number of GH-secreting cells within 16 h, increases GH gene expression in cells formerly not expressing this gene, confers somatotroph sensitivity to GHRH and TRH, and induces GH production in a precursor population found primarily in the caudal lobe of the anterior pituitary, a site consistent with GH localization in adults.	Corticosterone	17-31	growth hormone	Gallus gallus	98-100
11375120-14	2001	We conclude that corticosterone increases the number of GH-secreting cells within 16 h, increases GH gene expression in cells formerly not expressing this gene, confers somatotroph sensitivity to GHRH and TRH, and induces GH production in a precursor population found primarily in the caudal lobe of the anterior pituitary, a site consistent with GH localization in adults.	Corticosterone	17-31	growth hormone	Gallus gallus	98-100
11412336-4	2001	The growth response with continuous infusion of GHRP-6 was transient, accompanied by suppression of GH and corticosterone responses to bolus injection of GHRP-6.	Corticosterone	107-121	gonadotropin releasing hormone receptor	Rattus norvegicus	48-50
11412336-6	2001	In contrast, pulsatile (3-hourly) infusion of GHRP-6 produced sustained growth and GH responses, which were accompanied by suppression of corticosterone responses and elevated arcuate GH-releasing factor (GRF) mRNA expression.	Corticosterone	138-152	gonadotropin releasing hormone receptor	Rattus norvegicus	46-48
11412343-5	2001	injection of orexin-A (3 nmol) in male rats stimulated increases in plasma concentrations of corticosterone between 10 and 40 min after injection, and of plasma ACTH at 20 and 90 min after injection.	Corticosterone	93-107	hypocretin neuropeptide precursor	Rattus norvegicus	13-21
11428664-8	2001	In fact, the plasma concentration of corticosterone, an endogenous P-glycoprotein substrate, increased 2-fold in CCl4-treated rats compared with control rats.	Corticosterone	37-51	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	67-81
11428664-8	2001	In fact, the plasma concentration of corticosterone, an endogenous P-glycoprotein substrate, increased 2-fold in CCl4-treated rats compared with control rats.	Corticosterone	37-51	C-C motif chemokine ligand 4	Rattus norvegicus	113-117
11428664-10	2001	In the systemic suppression of the P-glycoprotein function in the diseased state, the alteration of plasma concentrations or components of endogenous P-glycoprotein-related compounds, such as corticosterone, would likely be involved.	Corticosterone	192-206	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	35-49
11428664-10	2001	In the systemic suppression of the P-glycoprotein function in the diseased state, the alteration of plasma concentrations or components of endogenous P-glycoprotein-related compounds, such as corticosterone, would likely be involved.	Corticosterone	192-206	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	150-164
11457663-6	2001	In contrast, SNP significantly inhibited the stimulatory effects of ACTH, AII and ET-1 on corticosterone and aldosterone secretion.	Corticosterone	90-104	proopiomelanocortin	Homo sapiens	68-72
11457663-6	2001	In contrast, SNP significantly inhibited the stimulatory effects of ACTH, AII and ET-1 on corticosterone and aldosterone secretion.	Corticosterone	90-104	angiotensinogen	Homo sapiens	74-77
11457663-6	2001	In contrast, SNP significantly inhibited the stimulatory effects of ACTH, AII and ET-1 on corticosterone and aldosterone secretion.	Corticosterone	90-104	endothelin 1	Homo sapiens	82-86
11438350-4	2001	Following 24 h of maternal deprivation, the neonatal rat shows elevated basal levels of corticosterone (CORT) and exhibits a robust CORT and ACTH response to mild stress.	Corticosterone	88-102	cortistatin	Rattus norvegicus	104-108
11352769-5	2001	We found that Il4 was able to down-regulate the radiation-induced production of mediators of inflammation such as Gro1 (also known as KC, N51) in plasma and lung, corticosterone in blood, Il1b in lung, and prostaglandin E(2) in colon, suggesting the anti-inflammatory potential of Il4 in regulating the radiation-induced response.	Corticosterone	163-177	interleukin 4	Mus musculus	14-17
11376601-6	2001	LPS-induced plasma corticosterone levels tended to be lower after CRA 1000 pretreatment but it did not reach statistical significance.	Corticosterone	19-33	myotubularin related protein 11	Mus musculus	66-69
11411790-6	2001	Corticosterone-treatment of thymocytes in vitro decreased the number of CD4 and CD8 double positive cells, while co-culturing the cells with dehydrocorticosterone significantly attenuated this corticosterone effect (p&lt;0.0001).	Corticosterone	0-14	CD4 antigen	Mus musculus	72-75
11331386-0	2001	5-HT2A receptors stimulate ACTH, corticosterone, oxytocin, renin, and prolactin release and activate hypothalamic CRF and oxytocin-expressing cells.	Corticosterone	33-47	5-hydroxytryptamine receptor 2A	Rattus norvegicus	0-6
11403685-1	2001	Single administration of the cytokine interleukin-1beta (IL-1) or the psychostimulant amphetamine causes long-term sensitization of the hypothalamus pituitary adrenal (HPA) axis, i.e. enhanced adrenocorticotropine hormone (ACTH) and corticosterone responses weeks later.	Corticosterone	233-247	interleukin 1 beta	Rattus norvegicus	38-55
11328451-3	2001	injection of orexin-A (10 microg/rat) resulted in a rapid, significant increase in plasma ACTH and corticosterone concentrations.	Corticosterone	99-113	hypocretin neuropeptide precursor	Rattus norvegicus	13-21
11328451-6	2001	Orexin-A at a higher dose (30 microg/rat) also produced a rapid increase in plasma ACTH and corticosterone concentrations.	Corticosterone	92-106	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
11328454-5	2001	pretreatment with NPY antagonist or NPY antiserum (30 min or 24 h before orexin administration, respectively) inhibited the orexin-induced corticosterone release.	Corticosterone	139-153	neuropeptide Y	Rattus norvegicus	18-21
11328454-5	2001	pretreatment with NPY antagonist or NPY antiserum (30 min or 24 h before orexin administration, respectively) inhibited the orexin-induced corticosterone release.	Corticosterone	139-153	neuropeptide Y	Rattus norvegicus	36-39
11328454-5	2001	pretreatment with NPY antagonist or NPY antiserum (30 min or 24 h before orexin administration, respectively) inhibited the orexin-induced corticosterone release.	Corticosterone	139-153	hypocretin neuropeptide precursor	Rattus norvegicus	73-79
11328454-5	2001	pretreatment with NPY antagonist or NPY antiserum (30 min or 24 h before orexin administration, respectively) inhibited the orexin-induced corticosterone release.	Corticosterone	139-153	hypocretin neuropeptide precursor	Rattus norvegicus	124-130
11282253-3	2001	Chronic fluoxetine treatment significantly attenuated the anorexia and body weight loss, as well as the depletion of CRH-41 from the median eminence and the elevation in serum corticosterone levels induced by LPS.	Corticosterone	176-190	toll-like receptor 4	Mus musculus	209-212
11383709-0	2001	Opposite effects of antidepressants and corticosterone on the sensitivity of hippocampal CA1 neurons to 5-HT1A and 5-HT4 receptor activation.	Corticosterone	40-54	carbonic anhydrase 1	Rattus norvegicus	89-92
11383709-0	2001	Opposite effects of antidepressants and corticosterone on the sensitivity of hippocampal CA1 neurons to 5-HT1A and 5-HT4 receptor activation.	Corticosterone	40-54	5-hydroxytryptamine receptor 1A	Rattus norvegicus	104-110
11383709-9	2001	These findings indicate that antidepressant treatments and repeated corticosterone have opposite effects on hippocampal responsiveness to 5-HT1A and 5-HT4 receptor activation.	Corticosterone	68-82	5-hydroxytryptamine receptor 1A	Rattus norvegicus	138-144
11383709-10	2001	In consequence, antidepressants enhance, whereas corticosterone reduces the 5-HT-mediated inhibition of hippocampal CA1 cells, which may be relevant to the antidepressant and pro-depressant effects of either treatment, respectively.	Corticosterone	49-63	carbonic anhydrase 1	Rattus norvegicus	116-119
11360001-7	2001	Additional activation of 5-HT1A postsynaptic receptors was indicated by the increase of corticosterone plasma levels induced by B-20991 in the rat.	Corticosterone	88-102	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	25-31
11274359-1	2001	11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) intracellularly regenerates active corticosterone from circulating inert 11-dehydrocorticosterone (11-DHC) in specific tissues.	Corticosterone	93-107	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	44-56
11274359-3	2001	In intact hippocampal cells in culture, 11beta-HSD-1 acts as a functional 11beta-reductase reactivating inert 11-DHC to corticosterone, thereby potentiating kainate neurotoxicity.	Corticosterone	120-134	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	40-52
11274359-6	2001	In contrast, despite elevated plasma corticosterone levels throughout life, this glucocorticoid-associated learning deficit was ameliorated in aged 11beta-HSD-1 knockout mice, implicating lower intraneuronal corticosterone levels through lack of 11-DHC reactivation.	Corticosterone	208-222	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	148-160
11301070-2	2001	Whether corticosterone plays a role in the clozapine-induced Fos response is the subject of this study.	Corticosterone	8-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	61-64
11301070-6	2001	Implantation of the corticosterone pellet in both sham-operated and adrenalectomized animals, reduced the clozapine-induced Fos responses strongly in the hypothalamic paraventricular nucleus, the subfornical organ and possibly in the prefrontal cortex; in the supraoptic nucleus, this effect was seen only in intact animals.	Corticosterone	20-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	124-127
11345969-3	2001	Neurogenic insults (e.g., footshock, forced swim, restraint) and a systemic stressor (intraperitoneal interleukin-1beta treatment) likewise provoked a greater rise of plasma corticosterone in the BALB/cByJ mice.	Corticosterone	174-188	interleukin 1 beta	Mus musculus	102-119
11444434-0	2001	Regulation of chicken embryonic growth hormone secretion by corticosterone and triiodothyronine: evidence for a negative synergistic response.	Corticosterone	60-74	growth hormone	Gallus gallus	32-46
11275950-0	2001	Absence of D147E mutation of CYP11B2 gene in hypertensive patients with increased corticosterone and aldosterone production.	Corticosterone	82-96	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	29-36
11275950-2	2001	It has been shown that the conservative substitution D147E in the human CYP11B2 gene results in an increased production of corticosterone and aldosterone in vitro.	Corticosterone	123-137	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	72-79
11275950-4	2001	METHODS: In this study we investigated the presence of the mutation D147E of CYP11B2 in a group of 128 patients with primary aldosteronism, 68 patients with essential hypertension and increased corticosterone production and in 48 normal volunteers.	Corticosterone	194-208	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	77-84
11304519-8	2001	In corticosterone rats, Nos2 mRNA decreased in cortex by 68+/-5% and in medulla by 62+/-6%; Nos3 mRNA by 50+/-8% in cortex, and Nos1 by 29+/-7% in medulla (all P&lt;0.001 after Hochberg correction).	Corticosterone	3-17	nitric oxide synthase 2	Rattus norvegicus	24-28
11304519-8	2001	In corticosterone rats, Nos2 mRNA decreased in cortex by 68+/-5% and in medulla by 62+/-6%; Nos3 mRNA by 50+/-8% in cortex, and Nos1 by 29+/-7% in medulla (all P&lt;0.001 after Hochberg correction).	Corticosterone	3-17	nitric oxide synthase 1	Rattus norvegicus	128-132
11304519-11	2001	In conclusion, we have shown for the first time that the physiological components of glucocorticoid action (ACTH and corticosterone) when given chronically in vivo reduce Nos2 and Nos3 expression in the kidney.	Corticosterone	117-131	nitric oxide synthase 2	Rattus norvegicus	171-175
11304519-11	2001	In conclusion, we have shown for the first time that the physiological components of glucocorticoid action (ACTH and corticosterone) when given chronically in vivo reduce Nos2 and Nos3 expression in the kidney.	Corticosterone	117-131	nitric oxide synthase 3	Rattus norvegicus	180-184
11332709-1	2001	Endothelin-1 (ET-1) is a 21-amino acid residue (ET-1[1-21]) hypertensive peptide, which together with its receptor subtypes A and B (ETA and ETB) is expressed in the rat adrenal cortex, where it stimulates steroid-hormone (aldosterone and corticosterone) secretion through the ETB receptor and the growth (proliferative activity) of the zona glomerulosa (ZG) through the ETA receptor.	Corticosterone	239-253	endothelin 1	Rattus norvegicus	0-12
11332709-1	2001	Endothelin-1 (ET-1) is a 21-amino acid residue (ET-1[1-21]) hypertensive peptide, which together with its receptor subtypes A and B (ETA and ETB) is expressed in the rat adrenal cortex, where it stimulates steroid-hormone (aldosterone and corticosterone) secretion through the ETB receptor and the growth (proliferative activity) of the zona glomerulosa (ZG) through the ETA receptor.	Corticosterone	239-253	endothelin 1	Rattus norvegicus	14-18
11332709-1	2001	Endothelin-1 (ET-1) is a 21-amino acid residue (ET-1[1-21]) hypertensive peptide, which together with its receptor subtypes A and B (ETA and ETB) is expressed in the rat adrenal cortex, where it stimulates steroid-hormone (aldosterone and corticosterone) secretion through the ETB receptor and the growth (proliferative activity) of the zona glomerulosa (ZG) through the ETA receptor.	Corticosterone	239-253	endothelin 1	Rattus norvegicus	48-52
11332709-1	2001	Endothelin-1 (ET-1) is a 21-amino acid residue (ET-1[1-21]) hypertensive peptide, which together with its receptor subtypes A and B (ETA and ETB) is expressed in the rat adrenal cortex, where it stimulates steroid-hormone (aldosterone and corticosterone) secretion through the ETB receptor and the growth (proliferative activity) of the zona glomerulosa (ZG) through the ETA receptor.	Corticosterone	239-253	endothelin receptor type A	Rattus norvegicus	133-136
11332709-1	2001	Endothelin-1 (ET-1) is a 21-amino acid residue (ET-1[1-21]) hypertensive peptide, which together with its receptor subtypes A and B (ETA and ETB) is expressed in the rat adrenal cortex, where it stimulates steroid-hormone (aldosterone and corticosterone) secretion through the ETB receptor and the growth (proliferative activity) of the zona glomerulosa (ZG) through the ETA receptor.	Corticosterone	239-253	endothelin receptor type B	Rattus norvegicus	141-144
11340336-0	2001	Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse.	Corticosterone	22-36	corticotropin releasing hormone	Mus musculus	58-89
11340336-0	2001	Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse.	Corticosterone	22-36	agouti related neuropeptide	Mus musculus	91-113
11340336-0	2001	Effects of leptin and corticosterone on the expression of corticotropin-releasing hormone, agouti-related protein, and proopiomelanocortin in the brain of ob/ob mouse.	Corticosterone	22-36	pro-opiomelanocortin-alpha	Mus musculus	119-138
11340336-1	2001	The present study was conducted to assess the effect of leptin and corticosterone on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain.	Corticosterone	67-81	corticotropin releasing hormone	Mus musculus	103-134
11340336-1	2001	The present study was conducted to assess the effect of leptin and corticosterone on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain.	Corticosterone	67-81	corticotropin releasing hormone	Mus musculus	136-139
11340336-1	2001	The present study was conducted to assess the effect of leptin and corticosterone on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain.	Corticosterone	67-81	pro-opiomelanocortin-alpha	Mus musculus	142-161
11340336-1	2001	The present study was conducted to assess the effect of leptin and corticosterone on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain.	Corticosterone	67-81	pro-opiomelanocortin-alpha	Mus musculus	163-167
11340336-1	2001	The present study was conducted to assess the effect of leptin and corticosterone on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain.	Corticosterone	67-81	agouti related neuropeptide	Mus musculus	173-195
11340336-1	2001	The present study was conducted to assess the effect of leptin and corticosterone on the expression of corticotropin-releasing hormone (CRH), proopiomelanocortin (POMC) and agouti-related protein (AGRP) in the mouse brain.	Corticosterone	67-81	agouti related neuropeptide	Mus musculus	197-201
11340336-3	2001	Leptin and corticosterone downregulated CRH expression in the paraventricular hypothalamic nucleus (PVH).	Corticosterone	11-25	corticotropin releasing hormone	Mus musculus	40-43
11340336-4	2001	Leptin prevented the stimulating effects of ADX on the expression of CRH and the combination of small doses of leptin and corticosterone was as potent as the high dose of corticosterone in suppressing CRH mRNA expression in the PVH.	Corticosterone	122-136	corticotropin releasing hormone	Mus musculus	201-204
11340336-4	2001	Leptin prevented the stimulating effects of ADX on the expression of CRH and the combination of small doses of leptin and corticosterone was as potent as the high dose of corticosterone in suppressing CRH mRNA expression in the PVH.	Corticosterone	171-185	corticotropin releasing hormone	Mus musculus	201-204
11340336-5	2001	Leptin and corticosterone enhanced the expression of CRH in the central nucleus of amygdala and in the bed nucleus of the stria terminalis.	Corticosterone	11-25	corticotropin releasing hormone	Mus musculus	53-56
11340336-6	2001	In addition, the present results confirmed the downregulating effects of leptin on the expression of AGRP mRNA in the hypothalamic arcuate nucleus (ARC), and demonstrated that this effect was more apparent in ADX mice treated with corticosterone than in ADX mice not supplemented with corticosterone.	Corticosterone	231-245	leptin	Mus musculus	73-79
11340336-6	2001	In addition, the present results confirmed the downregulating effects of leptin on the expression of AGRP mRNA in the hypothalamic arcuate nucleus (ARC), and demonstrated that this effect was more apparent in ADX mice treated with corticosterone than in ADX mice not supplemented with corticosterone.	Corticosterone	231-245	agouti related neuropeptide	Mus musculus	101-105
11340336-6	2001	In addition, the present results confirmed the downregulating effects of leptin on the expression of AGRP mRNA in the hypothalamic arcuate nucleus (ARC), and demonstrated that this effect was more apparent in ADX mice treated with corticosterone than in ADX mice not supplemented with corticosterone.	Corticosterone	285-299	leptin	Mus musculus	73-79
11340336-6	2001	In addition, the present results confirmed the downregulating effects of leptin on the expression of AGRP mRNA in the hypothalamic arcuate nucleus (ARC), and demonstrated that this effect was more apparent in ADX mice treated with corticosterone than in ADX mice not supplemented with corticosterone.	Corticosterone	285-299	agouti related neuropeptide	Mus musculus	101-105
11340336-7	2001	Also, leptin and corticosterone had opposite effects on the expression of POMC in the ARC.	Corticosterone	17-31	pro-opiomelanocortin-alpha	Mus musculus	74-78
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	34-48	pro-opiomelanocortin-alpha	Mus musculus	70-74
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	34-48	agouti related neuropeptide	Mus musculus	79-83
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	34-48	pro-opiomelanocortin-alpha	Mus musculus	233-237
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	34-48	agouti related neuropeptide	Mus musculus	242-246
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	34-48	leptin	Mus musculus	285-291
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	296-310	leptin	Mus musculus	23-29
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	296-310	pro-opiomelanocortin-alpha	Mus musculus	70-74
11340336-8	2001	The opposite effect of leptin and corticosterone on the expression of POMC and AGRP seems consistent with the reported effects that these hormones and peptides have on food intake and thermogenesis, suggesting that the modulation of POMC and AGRP expression can be a mechanism whereby leptin and corticosterone exert their effects in the regulation of energy balance.	Corticosterone	296-310	agouti related neuropeptide	Mus musculus	79-83
11260660-10	2001	Swimming stress also resulted in marked elevation in both ACTH and corticosterone levels, which were 10-20 fold higher (541.8 compared to 27.2-59.1 pg/dl for ACTH) and 2-5 fold higher (45.7 compared to 8.4- 20.0 microg/dl for corticosteroids) than the cage control animals.	Corticosterone	67-81	proopiomelanocortin	Homo sapiens	158-162
11277981-5	2001	We hypothesized that dexamethasone, corticosterone and serotonin exposure modify GR and MR mRNA levels in fetal mouse hippocampal cultures, and that these effects are confined to neurons.	Corticosterone	36-50	nuclear receptor subfamily 3, group C, member 1	Mus musculus	81-83
11277981-5	2001	We hypothesized that dexamethasone, corticosterone and serotonin exposure modify GR and MR mRNA levels in fetal mouse hippocampal cultures, and that these effects are confined to neurons.	Corticosterone	36-50	nuclear receptor subfamily 3, group C, member 2	Mus musculus	88-90
11277981-10	2001	Four days exposure to dexamethasone or corticosterone (10 or 100 nM) decreased levels of GR mRNA within neurons.	Corticosterone	39-53	nuclear receptor subfamily 3, group C, member 1	Mus musculus	89-91
11295232-0	2001	Norepinephrine-induced CRH and AVP gene transcription within the hypothalamus: differential regulation by corticosterone.	Corticosterone	106-120	arginine vasopressin	Rattus norvegicus	31-34
11295232-2	2001	We hypothesized that this differential response is due to differential sensitivity of AVP and CRH gene transcription to the inhibitory effects of the NE-induced rise in corticosterone.	Corticosterone	169-183	arginine vasopressin	Rattus norvegicus	86-89
11295232-2	2001	We hypothesized that this differential response is due to differential sensitivity of AVP and CRH gene transcription to the inhibitory effects of the NE-induced rise in corticosterone.	Corticosterone	169-183	corticotropin releasing hormone	Rattus norvegicus	94-97
11295232-9	2001	These results suggest that corticosterone has a greater impact on the transcriptional regulation of AVP than CRH, suggesting important differences and distinct roles of these secretagogues in the regulation of the hypothalamic-pituitary-adrenal axis.	Corticosterone	27-41	arginine vasopressin	Rattus norvegicus	100-103
11223006-6	2001	Following ICV injection of 0.2 nmol CART(55-102), a dose which significantly reduces food intake, plasma prolactin (PRL), growth hormone (GH) and adrenocorticotrophin hormone (ACTH) and corticosterone increased significantly.	Corticosterone	186-200	CART prepropeptide	Rattus norvegicus	36-40
11576624-2	2001	The NAD(+)-dependent 11-HSD 2 in the kidney inactivates corticosterone and cortisol, allowing aldosterone, which is not metabolized, access to the receptor.	Corticosterone	56-70	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	24-29
11488913-7	2001	When injected intravenously into adult chickens, purified recombinant ChIL-6 induced an increase in serum corticosterone levels.	Corticosterone	106-120	interleukin 6	Gallus gallus	70-76
11515823-6	2001	LPS and TNF-alpha, however, induced similar levels of corticosterone with or without concomitant CpG DNA.	Corticosterone	54-68	tumor necrosis factor	Mus musculus	8-17
11515823-8	2001	Exogenous TNF-alpha administered in vivo induced comparable concentrations of corticosterone with or without CpG DNA.	Corticosterone	78-92	tumor necrosis factor	Mus musculus	10-19
11694038-1	2001	Prolactin significantly increased the rate of fatty acid synthesis in explants of mid-pregnant rat mammary gland cultured for 96 h with insulin plus corticosterone.	Corticosterone	149-163	prolactin	Rattus norvegicus	0-9
11474219-1	2001	We have shown in a previous study that high corticosterone levels during repeated immobilization stress result in a reduction of glucocorticoid receptor (GR) mRNA in the hypothalamic paraventricular nucleus (PVN) and the hippocampus.	Corticosterone	44-58	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	129-152
11474219-1	2001	We have shown in a previous study that high corticosterone levels during repeated immobilization stress result in a reduction of glucocorticoid receptor (GR) mRNA in the hypothalamic paraventricular nucleus (PVN) and the hippocampus.	Corticosterone	44-58	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	154-156
11474219-7	2001	In the presence of high corticosterone, starvation resulted in a decrease in both CRH mRNA and type-1 CRH receptor mRNA in the PVN.	Corticosterone	24-38	corticotropin releasing hormone	Rattus norvegicus	82-85
11474219-7	2001	In the presence of high corticosterone, starvation resulted in a decrease in both CRH mRNA and type-1 CRH receptor mRNA in the PVN.	Corticosterone	24-38	corticotropin releasing hormone	Rattus norvegicus	102-105
11257496-0	2001	Corticosterone-induced rapid phosphorylation of p38 and JNK mitogen-activated protein kinases in PC12 cells.	Corticosterone	0-14	mitogen activated protein kinase 14	Rattus norvegicus	48-51
11257496-0	2001	Corticosterone-induced rapid phosphorylation of p38 and JNK mitogen-activated protein kinases in PC12 cells.	Corticosterone	0-14	mitogen-activated protein kinase 8	Rattus norvegicus	56-59
11257496-1	2001	The present study showed that corticosterone (B) could induce a rapid activation of p38 and c-Jun NH(2)-terminal protein kinase (JNK) in PC12 cells.	Corticosterone	30-44	mitogen activated protein kinase 14	Rattus norvegicus	84-87
11257496-1	2001	The present study showed that corticosterone (B) could induce a rapid activation of p38 and c-Jun NH(2)-terminal protein kinase (JNK) in PC12 cells.	Corticosterone	30-44	mitogen-activated protein kinase 8	Rattus norvegicus	92-127
11257496-1	2001	The present study showed that corticosterone (B) could induce a rapid activation of p38 and c-Jun NH(2)-terminal protein kinase (JNK) in PC12 cells.	Corticosterone	30-44	mitogen-activated protein kinase 8	Rattus norvegicus	129-132
11222988-9	2001	Corticosterone was found significantly lowered in the alpha-CRH/saline group compared to the CNP treated group but not compared to saline controls.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	60-63
11762707-8	2001	In contrast, we found a reduction in the mRNA of the antiapoptotic gene bax and Bax levels after ADX; both effects were prevented by corticosterone.	Corticosterone	133-147	BCL2 associated X, apoptosis regulator	Rattus norvegicus	80-83
11282455-2	2001	Pretreatment with dexamethasone, prednisolone and corticosterone for 60 min decreased insulin-induced [3H] 2-deoxyglucose (DOG) uptake in isolated rat adipocytes.	Corticosterone	50-64	insulin	Canis lupus familiaris	86-93
11427916-1	2001	Administration of specific oligonucleotide selectively inhibiting alpha(2A)-adrenoceptor gene expression into the locus coeruleus of male rats for 3 days activated the hypothalamic-pituitary-adrenal system, which was manifested in a rise of blood plasma corticosterone content in rats with normal and hypertrophied (after castration) adrenal glands.	Corticosterone	254-268	adrenoceptor alpha 2A	Rattus norvegicus	66-88
11288760-1	2001	BACKGROUND: 11beta-hydroxysteroid dehydrogenase Type-2 (11beta-HSD2) is an unidirectional enzyme that catalyzes the conversion of glucocorticoid hormones cortisol and corticosterone (B) into their corresponding inactive forms, cortisone, and 11-dehydrocorticosterone (DH-B).	Corticosterone	167-181	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	12-54
11394640-7	2001	The corticotropin-releasing hormone (CRH) antagonist alpha-helical CRH9-41, applied 30 min prior to EM1 administration, completely abolished the increases in both locomotion and the number of rearings and attenuated the corticosterone release evoked by EM1.	Corticosterone	220-234	corticotropin releasing hormone	Mus musculus	4-35
11394640-7	2001	The corticotropin-releasing hormone (CRH) antagonist alpha-helical CRH9-41, applied 30 min prior to EM1 administration, completely abolished the increases in both locomotion and the number of rearings and attenuated the corticosterone release evoked by EM1.	Corticosterone	220-234	corticotropin releasing hormone	Mus musculus	37-40
11254747-10	2001	The reduced serum leptin levels could not be explained by nutritional restriction as evaluated by serum levels of glucose and corticosterone.	Corticosterone	126-140	leptin	Rattus norvegicus	18-24
11307039-9	2001	These results suggest that BN-like peptides may regulate certain hypothalamic and extrahypothalamic circuits, including the HPA axis, by affecting regional utilization of ir-CRH and ir-AVP, and/or by provoking the release of these peptides at the Me/Arc, thus increasing their availability downstream at the anterior pituitary and increasing circulating ACTH and corticosterone levels.	Corticosterone	363-377	gastrin releasing peptide	Homo sapiens	27-29
11348834-6	2001	Furthermore, across prenatal groups, lower corticosterone (CORT) levels were found in handled compared to nonhandled animals during reexposure under food-deprived conditions, emphasizing the importance of assessing both behavior and HPA function when examining an animal"s response to a task and indicating that handling may not be effective at attenuating some deficits in E animals.	Corticosterone	43-57	cortistatin	Homo sapiens	59-63
11285013-1	2001	Low doses of lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), or exposure to a stressor (restraint) increased plasma corticosterone levels.	Corticosterone	162-176	tumor necrosis factor	Mus musculus	63-72
11285013-1	2001	Low doses of lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), or exposure to a stressor (restraint) increased plasma corticosterone levels.	Corticosterone	162-176	interleukin 1 beta	Mus musculus	75-93
11285013-1	2001	Low doses of lipopolysaccharide, tumour necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), or exposure to a stressor (restraint) increased plasma corticosterone levels.	Corticosterone	162-176	interleukin 1 beta	Mus musculus	95-104
11285013-2	2001	In animals pretreated with lipopolysaccharide, a marked sensitization of the corticosterone response was evident upon subsequent exposure to lipopolysaccharide, TNF-alpha, or restraint, 1 day later.	Corticosterone	77-91	tumor necrosis factor	Mus musculus	161-170
11285013-7	2001	Macrophage depletion by a suspension of clodronate liposomes attenuated the plasma corticosterone changes induced by TNF-alpha, but did not affect the sensitization.	Corticosterone	83-97	tumor necrosis factor	Mus musculus	117-126
11343623-1	2001	The 5-HT1A agonist 8-OH-DPAT produces a hypothermia in mice mediated by somatodendritic 5-HT1A receptors, that is attenuated by antidepressants and corticosterone.	Corticosterone	148-162	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	4-10
11343623-1	2001	The 5-HT1A agonist 8-OH-DPAT produces a hypothermia in mice mediated by somatodendritic 5-HT1A receptors, that is attenuated by antidepressants and corticosterone.	Corticosterone	148-162	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	88-94
11343623-6	2001	This demonstrates a serotonergic-nicotinic interaction in the generation of hypothermia in mice and is consistent with corticosterone selectively attenuating somatodendritic 5-HT1A receptor function.	Corticosterone	119-133	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	174-189
11288760-1	2001	BACKGROUND: 11beta-hydroxysteroid dehydrogenase Type-2 (11beta-HSD2) is an unidirectional enzyme that catalyzes the conversion of glucocorticoid hormones cortisol and corticosterone (B) into their corresponding inactive forms, cortisone, and 11-dehydrocorticosterone (DH-B).	Corticosterone	167-181	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	56-67
11288760-1	2001	BACKGROUND: 11beta-hydroxysteroid dehydrogenase Type-2 (11beta-HSD2) is an unidirectional enzyme that catalyzes the conversion of glucocorticoid hormones cortisol and corticosterone (B) into their corresponding inactive forms, cortisone, and 11-dehydrocorticosterone (DH-B).	Corticosterone	167-181	DNA helicase B	Homo sapiens	268-272
11172788-3	2001	The effect of adrenalectomy (ADX) and corticosterone (CORT) replacement on the expression of NGF mRNA in the hippocampus after TBI has not been investigated to date.	Corticosterone	38-52	nerve growth factor	Rattus norvegicus	93-96
11223190-7	2001	Despite the evidence for expression of a ligand-binding domain fragment of the glucocorticoid receptor these mice are profoundly glucocorticoid resistant, with elevated levels of plasma ACTH and corticosterone.	Corticosterone	195-209	nuclear receptor subfamily 3, group C, member 1	Mus musculus	79-102
11172788-3	2001	The effect of adrenalectomy (ADX) and corticosterone (CORT) replacement on the expression of NGF mRNA in the hippocampus after TBI has not been investigated to date.	Corticosterone	54-58	nerve growth factor	Rattus norvegicus	93-96
11212944-0	2001	Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress.	Corticosterone	120-134	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	40-44
11212944-0	2001	Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress.	Corticosterone	120-134	immunoglobulin heavy variable V1-9	Mus musculus	46-51
11212944-0	2001	Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress.	Corticosterone	120-134	interleukin 2	Mus musculus	53-57
11212944-0	2001	Quantitative modeling of suppression of IgG1, IgG2a, IL-2, and IL-4 responses to antigen in mice treated with exogenous corticosterone or restraint stress.	Corticosterone	120-134	interleukin 4	Mus musculus	63-67
11212944-5	2001	Cumulative corticosterone exposure in these mice, expressed as the area under the curve (AUC) of corticosterone concentration versus time, was used to develop quantitative models of the effects of corticosterone on the immunoglobulin (Ig) G1 and IgG2a responses to keyhole limpet hemocyanin (KLH) and sheep erythrocytes (sRBC).	Corticosterone	11-25	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	219-241
11212944-5	2001	Cumulative corticosterone exposure in these mice, expressed as the area under the curve (AUC) of corticosterone concentration versus time, was used to develop quantitative models of the effects of corticosterone on the immunoglobulin (Ig) G1 and IgG2a responses to keyhole limpet hemocyanin (KLH) and sheep erythrocytes (sRBC).	Corticosterone	11-25	immunoglobulin heavy variable V1-9	Mus musculus	246-251
11212944-8	2001	Restraint had a greater effect (at equivalent corticosterone AUC values) than exogenous corticosterone, suggesting that mediators in addition to corticosterone are important in suppression of the IgG1 and IgG2a response to KLH.	Corticosterone	88-102	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	196-200
11212944-8	2001	Restraint had a greater effect (at equivalent corticosterone AUC values) than exogenous corticosterone, suggesting that mediators in addition to corticosterone are important in suppression of the IgG1 and IgG2a response to KLH.	Corticosterone	88-102	immunoglobulin heavy variable V1-9	Mus musculus	205-210
11212944-8	2001	Restraint had a greater effect (at equivalent corticosterone AUC values) than exogenous corticosterone, suggesting that mediators in addition to corticosterone are important in suppression of the IgG1 and IgG2a response to KLH.	Corticosterone	88-102	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	196-200
11212944-8	2001	Restraint had a greater effect (at equivalent corticosterone AUC values) than exogenous corticosterone, suggesting that mediators in addition to corticosterone are important in suppression of the IgG1 and IgG2a response to KLH.	Corticosterone	88-102	immunoglobulin heavy variable V1-9	Mus musculus	205-210
11212944-11	2001	The relationships between corticosterone AUC and the IgG1 and IgG2a responses to sRBC were nonlinear and characterized by enhanced responses at low to moderate AUC values.	Corticosterone	26-40	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	53-57
11212944-11	2001	The relationships between corticosterone AUC and the IgG1 and IgG2a responses to sRBC were nonlinear and characterized by enhanced responses at low to moderate AUC values.	Corticosterone	26-40	immunoglobulin heavy variable V1-9	Mus musculus	62-67
11244301-4	2001	Surprisingly, the ability of the glucocorticoid corticosterone (CORT) to either enhance or inhibit T-cell proliferation was found to depend primarily on the cell density and the timing of the cultures.	Corticosterone	48-62	cortistatin	Rattus norvegicus	64-68
11158929-1	2001	We explored the contribution of the suprachiasmatic nucleus (SCN) in ACTH and corticosterone (CORT) diurnal responsiveness of the rat to restraint stress applied either in the morning (AM) or in the evening (PM).	Corticosterone	78-92	cortistatin	Rattus norvegicus	94-98
11403094-7	2001	It is likely that CRH-R2 does not play an important role in hypothalamic-pituitary adrenal axis regulation, though it has been reported that CRH-R2-deficient mice showed hyperresponse of ACTH and corticosterone.	Corticosterone	196-210	corticotropin releasing hormone receptor 2	Mus musculus	141-147
11403098-7	2001	The reduced inactivation of cortisol by 11betaHSD2 observed in EAS is likely to be in part due to end product inhibition or substrate overload of the enzyme by endogenous substrates (cortisol, corticosterone, etc) rather than inhibition of 11betaHSD2 at the transcriptional level by either ACTH or ACTH regulated steroids.	Corticosterone	193-207	11-beta-hydroxysteroid dehydrogenase type 2	Ovis aries	40-50
11403102-5	2001	The bioactivity of the high molecular weight ACTH in patient plasma was lower than the reference range of 1-39 ACTH, which is determined by the ability of dispersed rat adrenocortical cells to secrete corticosterone.	Corticosterone	201-215	proopiomelanocortin	Homo sapiens	45-49
11403102-5	2001	The bioactivity of the high molecular weight ACTH in patient plasma was lower than the reference range of 1-39 ACTH, which is determined by the ability of dispersed rat adrenocortical cells to secrete corticosterone.	Corticosterone	201-215	proopiomelanocortin	Homo sapiens	111-115
11208575-3	2001	Treatment with the vasopressin pressor (V(1)) receptor antagonist [d(CH(2))(5)Tyr(Me)-AVP] before ethanol administration significantly reduced the ACTH and corticosterone level increases.	Corticosterone	156-170	arginine vasopressin	Rattus norvegicus	86-89
11208581-9	2001	Peripheral injection of leptin increased serum corticosterone level and decreased hypothalamic neuropeptide Y mRNA expression in rats fed the low-fat but not the high-fat diet for 20 days.	Corticosterone	47-61	leptin	Rattus norvegicus	24-30
11168566-0	2001	Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stress.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	54-84
11168566-0	2001	Corticosterone differentially modulates expression of corticotropin releasing factor and arginine vasopressin mRNA in the hypothalamic paraventricular nucleus following either acute or repeated restraint stress.	Corticosterone	0-14	arginine vasopressin	Rattus norvegicus	98-109
11168566-10	2001	These experiments show that corticosterone has important modulating effects on the adaptive pattern of both CRF and AVP mRNA expression in the parvocellular PVN.	Corticosterone	28-42	arginine vasopressin	Rattus norvegicus	116-119
11168566-11	2001	The "set-point" of corticosterone differs; for CRF, experiencing higher levels is necessary for subsequent adaptation to repeated restraint to occur, whereas for AVP a return to lower levels is necessary to allow this peptide to respond to repeated stress.	Corticosterone	19-33	arginine vasopressin	Rattus norvegicus	162-165
11292165-0	2001	Bcl-2 and Bax expression in cartilage and bone cells after high-dose corticosterone treatment in rats.	Corticosterone	69-83	BCL2, apoptosis regulator	Rattus norvegicus	0-5
11243496-0	2001	Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal.	Corticosterone	0-14	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	28-43
11243496-0	2001	Corticosterone responses in 5-HT1B receptor knockout mice to stress or 5-HT1A receptor activation are normal.	Corticosterone	0-14	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	71-86
11243496-2	2001	Stress and 5-HT1A receptor agonists induce corticosterone release in mice via hypothalamus-pituitary-adrenal (HPA) axis activation.	Corticosterone	43-57	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	11-26
11243496-10	2001	Activation of 5-HT1A receptors caused a strong dose-dependent release of corticosterone in both genotypes.	Corticosterone	73-87	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	14-20
11292165-0	2001	Bcl-2 and Bax expression in cartilage and bone cells after high-dose corticosterone treatment in rats.	Corticosterone	69-83	BCL2 associated X, apoptosis regulator	Rattus norvegicus	10-13
11292165-1	2001	The expression of Bcl-2 and Bax has been evaluated by immunohistochemistry in normal rats, and in rats after treatment with high-dose corticosterone (CORT).	Corticosterone	134-148	BCL2, apoptosis regulator	Rattus norvegicus	18-23
11292165-1	2001	The expression of Bcl-2 and Bax has been evaluated by immunohistochemistry in normal rats, and in rats after treatment with high-dose corticosterone (CORT).	Corticosterone	134-148	cortistatin	Rattus norvegicus	150-154
11137865-0	2001	Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies.	Corticosterone	22-36	5-hydroxytryptamine receptor 1A	Rattus norvegicus	40-47
11201075-3	2001	A substantial increase was observed in the population of bFGF RNA-expressing glial cells after acute corticosterone treatment (10 mg/kg, s.c.) in subregions of the CA1 area and the dentate gyrus but no changes were observed after adrenalectomy.	Corticosterone	101-115	fibroblast growth factor 2	Rattus norvegicus	57-61
11201075-3	2001	A substantial increase was observed in the population of bFGF RNA-expressing glial cells after acute corticosterone treatment (10 mg/kg, s.c.) in subregions of the CA1 area and the dentate gyrus but no changes were observed after adrenalectomy.	Corticosterone	101-115	carbonic anhydrase 1	Rattus norvegicus	164-167
11201075-5	2001	These data suggest that in a subpopulation of hippocampal glial cells corticosterone regulates bFGF gene expression transcriptionally in an on/off manner.	Corticosterone	70-84	fibroblast growth factor 2	Rattus norvegicus	95-99
11165006-3	2001	11beta-HSD-2 acts as a dehydrogenase, converting active corticosterone (cortisol in humans) to its inactive 11-keto derivative (11-dehydrocorticosterone in rodents and cortisone in humans), whereas 11beta-HSD-1 acts as a reductase, regenerating active glucocorticoids in a tissue-specific manner.	Corticosterone	56-70	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	0-12
11165006-3	2001	11beta-HSD-2 acts as a dehydrogenase, converting active corticosterone (cortisol in humans) to its inactive 11-keto derivative (11-dehydrocorticosterone in rodents and cortisone in humans), whereas 11beta-HSD-1 acts as a reductase, regenerating active glucocorticoids in a tissue-specific manner.	Corticosterone	56-70	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	198-210
11137865-0	2001	Functional effects of corticosterone on 5-HT(1A) and 5-HT(1B) receptor activity in rat brain: in vivo microdialysis studies.	Corticosterone	22-36	5-hydroxytryptamine receptor 1B	Rattus norvegicus	53-60
11255228-4	2001	However, enzyme activity studies showed only high affinity dehydrogenase activity (inactivation of corticosterone (B) to 11-dehydrocorticosterone (A)), characteristic of 11 beta-HSD2; conversion of B to A was higher in ROS 25/1&gt; UMR 106 cells&gt;ROS 17/2.8.	Corticosterone	99-113	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	170-182
11740147-8	2001	CONCLUSIONS: These results reveal that alcohol is able to induce hypertension and provide evidence that alcohol inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Corticosterone	232-246	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	148-159
11740147-8	2001	CONCLUSIONS: These results reveal that alcohol is able to induce hypertension and provide evidence that alcohol inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Corticosterone	232-246	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	164-171
11115609-4	2001	The selective agonist of ETB receptor BQ-3020 concentration-dependently increased aldosterone secretion from dispersed zona glomerulosa (ZG) cells and corticosterone secretion from dispersed zona fasciculata-reticularis (ZF/R) cells, and the NOS inhibitor NG-nitro-L-arginine methylester (L-NAME) potentiated the effect of BQ-3020 in a concentration-dependent manner.	Corticosterone	151-165	endothelin receptor type B	Rattus norvegicus	25-28
11115609-6	2001	ET-1, an agonist of both ETA and ETB receptors, stimulated the release of both aldosterone and corticosterone by in situ perfused rat adrenal gland.	Corticosterone	95-109	endothelin receptor type A	Rattus norvegicus	25-28
11115609-6	2001	ET-1, an agonist of both ETA and ETB receptors, stimulated the release of both aldosterone and corticosterone by in situ perfused rat adrenal gland.	Corticosterone	95-109	endothelin receptor type B	Rattus norvegicus	33-36
11150350-2	2001	In rats, stress-induced changes in CA3 apical dendritic structure are mediated by corticosterone (CORT) acting, in part, on excitatory amino acid neurotransmission.	Corticosterone	82-96	carbonic anhydrase 3	Rattus norvegicus	35-38
11150350-2	2001	In rats, stress-induced changes in CA3 apical dendritic structure are mediated by corticosterone (CORT) acting, in part, on excitatory amino acid neurotransmission.	Corticosterone	82-96	cortistatin	Rattus norvegicus	98-102
11734357-6	2001	In experiments 2 and 3, we found that the rat stress paradigm attenuated the elevation of basal and stress-induced corticosterone concentrations in the apoE-knockout mice towards concentrations observed in wild-type mice.	Corticosterone	115-129	apolipoprotein E	Rattus norvegicus	152-156
11226692-6	2001	In the rats that were not exposed to stress, nociceptin/orphanin FQ produced dose-orderly elevations of circulating adrenocorticotrophic hormone and corticosterone concentrations.	Corticosterone	149-163	prepronociceptin	Rattus norvegicus	45-55
11226692-6	2001	In the rats that were not exposed to stress, nociceptin/orphanin FQ produced dose-orderly elevations of circulating adrenocorticotrophic hormone and corticosterone concentrations.	Corticosterone	149-163	prepronociceptin	Rattus norvegicus	56-67
11226692-8	2001	In rats that were exposed to the mild stress of a novel environment, nociceptin/orphanin FQ administration enhanced the stress-induced elevations of plasma adrenocorticotrophic hormone concentrations and prolonged the stress-induced elevations of plasma corticosterone concentrations.	Corticosterone	254-268	prepronociceptin	Rattus norvegicus	69-79
11226692-8	2001	In rats that were exposed to the mild stress of a novel environment, nociceptin/orphanin FQ administration enhanced the stress-induced elevations of plasma adrenocorticotrophic hormone concentrations and prolonged the stress-induced elevations of plasma corticosterone concentrations.	Corticosterone	254-268	prepronociceptin	Rattus norvegicus	80-91
12045362-11	2001	In summary, these findings revealed a consistent predominant influence of ENDO on adrenal release of corticosterone as a concomitant to differential IL-1beta, ACTH and PRL release after AHA cell loss.	Corticosterone	101-115	interleukin 1 beta	Rattus norvegicus	149-157
12045362-11	2001	In summary, these findings revealed a consistent predominant influence of ENDO on adrenal release of corticosterone as a concomitant to differential IL-1beta, ACTH and PRL release after AHA cell loss.	Corticosterone	101-115	prolactin	Rattus norvegicus	168-171
11734357-8	2001	In conclusion, repeated exposure to a common environmental experience did abolish and reverse the difference in cognitive performance and corticosterone concentrations of apoE-knockout and wild-type mice.	Corticosterone	138-152	apolipoprotein E	Mus musculus	171-175
11179598-3	2001	Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels.	Corticosterone	153-167	corticotropin releasing hormone	Homo sapiens	12-15
11719001-25	2001	Rats receiving low dose corticosterone showed increased Fos-b expression following 9 days stress in the lateral septum and in the dorsal and medial parts of the paraventricular nucleus compared to either control, stressed rats or those receiving the higher corticosterone dose and repeated stress.	Corticosterone	24-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
11179598-1	2001	Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.	Corticosterone	108-122	gastrin releasing peptide	Homo sapiens	26-34
11179598-3	2001	Blockade of CRH receptors with alphah-CRF (10 microg) attenuated or blocked the BN-induced rise in plasma ACTH, epinephrine, norepinephrine, glucose and corticosterone levels.	Corticosterone	153-167	gastrin releasing peptide	Homo sapiens	80-82
11179598-1	2001	Central administration of bombesin (BN) (into the ventricular system) increased circulating levels of ACTH, corticosterone, epinephrine, norepinephrine and glucose, indicating that this peptide activates the hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system.	Corticosterone	108-122	gastrin releasing peptide	Homo sapiens	36-38
11169201-5	2001	Expression of A-SAA mRNA by HASMC was upregulated by corticoid hormones including dexamethasone (Dex), corticosterone, hydrocortisone, and aldosterone, but not by the cytokines interleukin (IL)-1, IL-6, and tumour necrosis factor (TNF)-alpha alone.	Corticosterone	103-117	serum amyloid A1 cluster	Homo sapiens	16-19
11824511-0	2001	Leptin inhibits cortisol and corticosterone secretion in pathologic human adrenocortical cells.	Corticosterone	29-43	leptin	Homo sapiens	0-6
11824511-3	2001	It was found that leptin effectively and dose-dependently inhibited basal and ACTH-stimulated cortisol and corticosterone secretion in the three types of human adrenocortical adenoma cells.	Corticosterone	107-121	leptin	Homo sapiens	18-24
11824511-4	2001	The inhibiting effect of basal corticosterone secretion was detectable in the presence of leptin concentration as low as 1 ng/ml, with decreases of corticosterone secretion to 34+/-4%, 57+/-11% and 79+/-9% in Cushing"s syndrome, primary aldosteronism, and nonhyperfunctioning adrenocortical adenoma cells, respectively.	Corticosterone	31-45	leptin	Homo sapiens	90-96
11824511-4	2001	The inhibiting effect of basal corticosterone secretion was detectable in the presence of leptin concentration as low as 1 ng/ml, with decreases of corticosterone secretion to 34+/-4%, 57+/-11% and 79+/-9% in Cushing"s syndrome, primary aldosteronism, and nonhyperfunctioning adrenocortical adenoma cells, respectively.	Corticosterone	148-162	leptin	Homo sapiens	90-96
11824511-6	2001	The inhibition of ACTH-stimulated cortisol and corticosterone secretion by leptin was similar to those found in cells without ACTH stimulation.	Corticosterone	47-61	leptin	Homo sapiens	75-81
11824511-8	2001	These results indicate that leptin is a potent inhibitor of cortisol and corticosterone secretion in human adenomatous adrenocortical cells.	Corticosterone	73-87	leptin	Homo sapiens	28-34
11102572-0	2000	Corticosterone inhibits generation of long-term potentiation in rat hippocampal slice: involvement of brain-derived neurotrophic factor.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	102-135
11102572-1	2000	In the present study, the effect of corticosterone (CORT) on the generation of long-term potentiation (LTP) and its underlying mechanism involving neurotrophin gene expression in CA1 synapses of rat hippocampal slice were examined.	Corticosterone	36-50	cortistatin	Rattus norvegicus	52-56
11102572-1	2000	In the present study, the effect of corticosterone (CORT) on the generation of long-term potentiation (LTP) and its underlying mechanism involving neurotrophin gene expression in CA1 synapses of rat hippocampal slice were examined.	Corticosterone	36-50	carbonic anhydrase 1	Rattus norvegicus	179-182
11120596-5	2000	Corticosterone preferentially depleted CD4+CD8+ cells in the thymus, whereas the same corticosterone exposure produced by restraint stress did not.	Corticosterone	0-14	CD4 antigen	Mus musculus	39-42
11090102-8	2000	Similarly, a specific anti-annexin 1 monoclonal antibody quenched the corticosterone-induced suppression of secretagogue-evoked GH release while an isotype matched control antibody was without effect.	Corticosterone	70-84	annexin A1	Rattus norvegicus	27-36
11216653-5	2000	In rats infused for 2 wk with angiotensin II (250 ng/[kg x min] subcutaneously), plasma angiotensin II, aldosterone, and corticosterone were raised 5.1-, 10.7-, and 2.3-fold, respectively, compared with control rats.	Corticosterone	121-135	angiotensinogen	Rattus norvegicus	30-44
11090102-8	2000	Similarly, a specific anti-annexin 1 monoclonal antibody quenched the corticosterone-induced suppression of secretagogue-evoked GH release while an isotype matched control antibody was without effect.	Corticosterone	70-84	gonadotropin releasing hormone receptor	Rattus norvegicus	128-130
11108297-2	2000	We examined whether corticosterone (CORT) responses to restraint stress could be attenuated by bilateral 50 nl microinjections of kynurenic acid (KYN, ionotropic glutamate receptor antagonist) into the medial PVN of conscious rats.	Corticosterone	20-34	cortistatin	Rattus norvegicus	36-40
11113077-7	2000	Concurrent plasma levels of interleukin (IL)-6, the major cytokine activating the hypothalamic-pituitary-adrenal axis, were markedly increased (495 +/- 131 vs. 20 +/- 1.5 pg/mL; P &lt; 0.0001), and this cytokine directly stimulated corticosterone secretion by adrenocortical cells in vitro.	Corticosterone	232-246	interleukin 6	Mus musculus	28-46
11216653-6	2000	Angiotensin II infusion raised corticosterone 11beta-oxidation 1.46- and 1.35-fold in renal cortical proximal and distal tubules (enriched by Percoll centrifugation), respectively, but had no effect on 11beta-HSD1 and 11beta-HSD2 mRNA levels (semiquantitative reverse transcriptase polymerase chain reaction), except for distal tubular 11beta-HSD1 mRNA, which was decreased to 50%.	Corticosterone	31-45	angiotensinogen	Rattus norvegicus	0-14
11216653-8	2000	The enhanced renal tubular corticosterone 11beta-oxidation in vivo may partly protect renal GR and MR from elevated plasma corticosterone on angiotensin II infusion.	Corticosterone	27-41	angiotensinogen	Rattus norvegicus	141-155
11216653-8	2000	The enhanced renal tubular corticosterone 11beta-oxidation in vivo may partly protect renal GR and MR from elevated plasma corticosterone on angiotensin II infusion.	Corticosterone	123-137	angiotensinogen	Rattus norvegicus	141-155
11115775-4	2000	First, a synthetic peptide approach demonstrated that the inhibitory effect of leptin on basal and ACTH-stimulated corticosterone secretion in vitro is, at least partially, mapped to a domain of the native protein between amino acids 116 and 130, i.e. an area of the molecule also relevant in terms of regulation of food intake and endocrine control.	Corticosterone	115-129	leptin	Rattus norvegicus	79-85
11115775-8	2000	Overall, our results provide evidence for a novel regulatory step at the level of Ob-R mRNA expression in the interplay between ACTH and leptin for the tuning of rat adrenal corticosterone secretion.	Corticosterone	174-188	leptin receptor	Rattus norvegicus	82-86
11115775-8	2000	Overall, our results provide evidence for a novel regulatory step at the level of Ob-R mRNA expression in the interplay between ACTH and leptin for the tuning of rat adrenal corticosterone secretion.	Corticosterone	174-188	leptin	Rattus norvegicus	137-143
11115781-2	2000	We have previously reported tissue-specific alterations in 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) in obese Zucker rats predicting that reactivation of corticosterone is decreased in liver but increased in omental fat.	Corticosterone	171-185	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	28-116
11239671-3	2000	The plasma corticosterone (CORT) response to open-field exposure was examined two further experiments.	Corticosterone	11-25	cortistatin	Rattus norvegicus	27-31
11078456-9	2000	Our data suggest that only falling leptin levels mediate the starvation-induced alterations in corticosterone levels and expression of hypothalamic neuropeptides, but inhibitors of leptin signaling are induced by both leptin and CNTF.	Corticosterone	95-109	leptin	Mus musculus	35-41
11161433-4	2000	When the anti-corticosterone drug aminoglutethimide (CYP11A1 inhibitor) was administered to B16F10 mice, corticosterone levels in splenic tissue or serum and CYP11A1 mRNA expression were decreased at 14 days after tumor inoculation.	Corticosterone	14-28	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	53-60
11161433-4	2000	When the anti-corticosterone drug aminoglutethimide (CYP11A1 inhibitor) was administered to B16F10 mice, corticosterone levels in splenic tissue or serum and CYP11A1 mRNA expression were decreased at 14 days after tumor inoculation.	Corticosterone	14-28	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	158-165
11161433-4	2000	When the anti-corticosterone drug aminoglutethimide (CYP11A1 inhibitor) was administered to B16F10 mice, corticosterone levels in splenic tissue or serum and CYP11A1 mRNA expression were decreased at 14 days after tumor inoculation.	Corticosterone	105-119	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	53-60
11161433-7	2000	Moreover, it was suggested that promotion of CYP11A1 mRNA expression in Th2 cells was partially involved due to an increase in level of corticosterone in splenic tissue and the breakdown of Th cell responses locally in the splenic tissue, which then affected the maintenance of Th2 cell functions in the microenvironment of tumor-bearing mice.	Corticosterone	136-150	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	45-52
11161433-7	2000	Moreover, it was suggested that promotion of CYP11A1 mRNA expression in Th2 cells was partially involved due to an increase in level of corticosterone in splenic tissue and the breakdown of Th cell responses locally in the splenic tissue, which then affected the maintenance of Th2 cell functions in the microenvironment of tumor-bearing mice.	Corticosterone	136-150	heart and neural crest derivatives expressed 2	Mus musculus	72-75
11501060-6	2000	Ang II enhanced AVP release, from (5.7 +/- 1.6) ng/ME in control decreasing to (2.6 +/- 1.2) ng/ME (P &lt; 0.05), meanwhile plasma corticosterone concentration was also increased markedly, from (356 +/- 58) in control to (536 +/- 134) micrograms/L plasma (P &lt; 0.05), which was partly abolished by administration of AVP antiserum.	Corticosterone	131-145	angiotensinogen	Rattus norvegicus	0-6
11089533-6	2000	LIF induction was concordant with elevated plasma ACTH and corticosterone levels and pituitary POMC messenger RNA (mRNA) expression.	Corticosterone	59-73	leukemia inhibitory factor	Mus musculus	0-3
11089561-7	2000	After continuous treatment with corticosterone, plasma AVP levels in homozygous Crhr1-/- mice were indistinguishable from those in wild-type littermates, thus providing evidence that glucocorticoid deficiency is the major driving force behind compensatory activation of the vasopressinergic system in Crhr1-/- mice.	Corticosterone	32-46	corticotropin releasing hormone receptor 1	Mus musculus	80-85
11196425-1	2000	11beta-hydroxylase and aldosterone synthase catalyse the final stages of corticosterone and aldosterone synthesis respectively.	Corticosterone	73-87	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	23-43
11196480-8	2000	SF-1 heterozygous mice exhibit a marked decrease in baseline and post-stress corticosterone with a concomitant increase in ACTH.	Corticosterone	77-91	nuclear receptor subfamily 5, group A, member 1	Mus musculus	0-4
11193932-0	2000	[Roles of neuropeptide Y in the expression of anticipatory corticosterone peak in rats under restricted daily feeding].	Corticosterone	59-73	neuropeptide Y	Rattus norvegicus	10-24
11053526-9	2000	The current study demonstrates that leptin rapidly influences the secretion of hypothalamic NPY and CRH and that these actions of leptin within the hypothalamus are restrained by the presence of endogenous corticosterone.	Corticosterone	206-220	leptin	Mus musculus	36-42
11053526-9	2000	The current study demonstrates that leptin rapidly influences the secretion of hypothalamic NPY and CRH and that these actions of leptin within the hypothalamus are restrained by the presence of endogenous corticosterone.	Corticosterone	206-220	leptin	Mus musculus	130-136
11164083-3	2000	PEA treatment induces: (i) a significant increase of corticotrophin releasing hormone (CRH) immunoreactivity in the median eminence (ME), as measured by semi-quantitative immunofluorescence labeling techniques, (ii) a significant increase in CRH mRNA levels in paraventricular nuclei, as detected by in situ hybridization, and (iii) an increase in plasma adreno-corticotrophin hormone (ACTH) and corticosterone levels in responses to stress.	Corticosterone	396-410	corticotropin releasing hormone	Rattus norvegicus	87-90
11092690-2	2000	In a previous study, we showed that surgical stress as measured by elevated endogenous corticosterone concentrations attenuated the endotoxin-induced tumor necrosis factor alpha (TNFalpha) response.	Corticosterone	87-101	tumor necrosis factor	Rattus norvegicus	179-187
11092690-7	2000	While peak serum TNFalpha concentrations were inversely related to baseline corticosterone concentrations, there was no correlation between peak IFN-gamma concentrations and baseline corticosterone concentrations or between TNFalpha and IFN-gamma concentrations.	Corticosterone	76-90	tumor necrosis factor	Rattus norvegicus	17-25
11018788-0	2000	Metyrapone, an inhibitor of corticosterone synthesis, blocks the kainic acid-induced expression of HSP 70.	Corticosterone	28-42	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	99-105
11018788-3	2000	The reduction in HSP 70 induction was paralleled by a complete prevention of the kainic acid-induced rise in the circulating corticosterone level by metyrapone; however, in applied doses metyrapone evoked slight enhancement of blood corticosterone.	Corticosterone	233-247	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	17-23
11053543-5	2000	Linear relationships between corticosterone AUC values and suppression of the following parameters were noted in B6C3F1 female mice: thymus cellularity and thymus subpopulation percentages, splenic subpopulation percentages, natural killer cell activity, MHC class II protein expression, and IgG1 and IgG2a antibody responses to antigen.	Corticosterone	29-43	LOC105243590	Mus musculus	292-296
11053543-5	2000	Linear relationships between corticosterone AUC values and suppression of the following parameters were noted in B6C3F1 female mice: thymus cellularity and thymus subpopulation percentages, splenic subpopulation percentages, natural killer cell activity, MHC class II protein expression, and IgG1 and IgG2a antibody responses to antigen.	Corticosterone	29-43	immunoglobulin heavy variable V1-9	Mus musculus	301-306
11342394-5	2000	In a first series of experiments, the possible regulation of corticosterone production by interleukin (IL)-1beta and peripheral catecholamines during restraint was assessed using a pharmacological approach in mice.	Corticosterone	61-75	interleukin 1 beta	Mus musculus	90-112
11342394-7	2000	By contrast, chemical sympathectomy potentiated the restraint-induced increase in plasma corticosterone concentration, this potentiation being reversed by IL-1ra.	Corticosterone	89-103	interleukin 1 receptor antagonist	Mus musculus	155-161
11342394-11	2000	The present data show that the stress-induced production of corticosterone was modulated by both peripheral catecholamines and IL-1beta.	Corticosterone	60-74	interleukin 1 beta	Mus musculus	127-135
11074297-3	2000	The secretion of adrenocorticotropin (ACTH) and corticosterone (CORT) in pituitary and adrenal glands, respectively, was assessed in ex vivo perifusion cultures.	Corticosterone	48-62	cortistatin	Rattus norvegicus	64-68
11059906-6	2000	In animals undergoing FPI, prior ADX caused further elevation of BDNF mRNA and this upregulation was prevented by corticosterone replacement in ADX rats.	Corticosterone	114-128	brain-derived neurotrophic factor	Rattus norvegicus	65-69
11045866-8	2000	RESULTS: For both males and females, DEX administration significantly reduced plasma adrenocorticotropic hormone (ACTH) and corticosterone (CORT) concentrations compared with SAL administration.	Corticosterone	124-138	cortistatin	Rattus norvegicus	140-144
11026651-5	2000	Systemic administration of corticosterone (CORT; 10 mg/rat/day for 12 days) or CORT pellet (200 mg) implant for 7 and 14 days also decreased CRHR-2 mRNA in the heart, whereas it was unchanged 7 days after adrenalectomy.	Corticosterone	27-41	cortistatin	Rattus norvegicus	43-47
11026651-5	2000	Systemic administration of corticosterone (CORT; 10 mg/rat/day for 12 days) or CORT pellet (200 mg) implant for 7 and 14 days also decreased CRHR-2 mRNA in the heart, whereas it was unchanged 7 days after adrenalectomy.	Corticosterone	27-41	corticotropin releasing hormone receptor 2	Rattus norvegicus	141-147
11012846-9	2000	The final experiment examined the corticosterone response to a corticotropin releasing hormone (CRH, 3 microg/kg i.p.)	Corticosterone	34-48	corticotropin releasing hormone	Rattus norvegicus	63-94
11012846-9	2000	The final experiment examined the corticosterone response to a corticotropin releasing hormone (CRH, 3 microg/kg i.p.)	Corticosterone	34-48	corticotropin releasing hormone	Rattus norvegicus	96-99
10989269-2	2000	Corticosterone regulates CA1 hippocampal physiology and the 5-HT(1A) receptor-effector pathway; however the effect of chronic stress levels of corticosterone is unknown.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	25-28
11258486-3	2000	Furthermore, adult MR-/- mice exhibited a significant reduction of granule cell neurogenesis to 65% of control levels, possibly mediated by GR due to elevated corticosterone plasma levels.	Corticosterone	159-173	nuclear receptor subfamily 3, group C, member 1	Mus musculus	140-142
11281373-10	2000	Plasma corticosterone levels in these mice are twofold higher than in controls, in contrast to similar plasma ACTH levels, thus indicating a direct effect of IGF-II on adrenal cell hyperplasia and function.	Corticosterone	7-21	insulin-like growth factor 2	Mus musculus	158-164
10989269-7	2000	The net effect of treatment with stress levels of corticosterone was to increase the excitability of the CA1 hippocampal pyramidal cell through changes in membrane properties and 5-HT(1A) receptor-mediated response.	Corticosterone	50-64	carbonic anhydrase 1	Rattus norvegicus	105-108
11028905-7	2000	Corticosterone treatment significantly inhibited glomerular infiltration of PMN, MO and LFA-1 positive cells after endotoxin infusion.	Corticosterone	0-14	integrin subunit alpha L	Rattus norvegicus	88-93
11028905-9	2000	CONCLUSIONS: It is concluded that pre-treatment with corticosterone inhibits the low dose endotoxin-induced glomerular inflammatory reaction in pregnant rats, most likely by inhibiting LFA-1 expression, thereby decreasing the adhesiveness of inflammatory cells for activated endothelial cells.	Corticosterone	53-67	integrin subunit alpha L	Rattus norvegicus	185-190
10996060-4	2000	injected with corticosterone (Cor) (15 mg kg(-1)).	Corticosterone	14-28	distribution of corticosterone in adrenal cortex cells	Mus musculus	30-33
10979239-8	2000	ET-1 raised the release of pregnenolone (as evaluated by blocking its further metabolism by cyanoketone), corticosterone, 18-hydroxycorticosterone, and aldosterone, without affecting that of 11-deoxycortisol, cortisol, and 11-deoxycorticosterone.	Corticosterone	106-120	endothelin 1	Homo sapiens	0-4
11019900-2	2000	The hormone increased plasma corticosterone (CORT) level, and induced an anxiogenic response as indicated by results from the elevated plus-maze test.	Corticosterone	29-43	cortistatin	Rattus norvegicus	45-49
10929089-6	2000	Administration of the COX-1/COX-2 inhibitor led to a complete blockage of ACTH and corticosterone secretion and POMC gene transcription.	Corticosterone	83-97	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	22-27
10929089-6	2000	Administration of the COX-1/COX-2 inhibitor led to a complete blockage of ACTH and corticosterone secretion and POMC gene transcription.	Corticosterone	83-97	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	28-33
10929089-10	2000	Moreover, we found a clear dissociation of the effect of the blockage of COXs upon ACTH and corticosterone secretion, suggesting that IL-1beta may act at the brain as well as at the adrenal cortex to stimulate the secretion of corticosterone.	Corticosterone	92-106	interleukin 1 beta	Rattus norvegicus	134-142
10929089-10	2000	Moreover, we found a clear dissociation of the effect of the blockage of COXs upon ACTH and corticosterone secretion, suggesting that IL-1beta may act at the brain as well as at the adrenal cortex to stimulate the secretion of corticosterone.	Corticosterone	227-241	interleukin 1 beta	Rattus norvegicus	134-142
11033331-10	2000	Furthermore, an in vivo microdialysis method is presented which allows the assessment of free corticosterone levels in the brain, which is critical for the study of the pharmacological basis of mineralocorticoid receptor (and glucocorticoid receptor) function.	Corticosterone	94-108	nuclear receptor subfamily 3 group C member 2	Homo sapiens	194-220
11033331-10	2000	Furthermore, an in vivo microdialysis method is presented which allows the assessment of free corticosterone levels in the brain, which is critical for the study of the pharmacological basis of mineralocorticoid receptor (and glucocorticoid receptor) function.	Corticosterone	94-108	nuclear receptor subfamily 3 group C member 1	Homo sapiens	226-249
11005876-1	2000	We report that 9 d of uncontrolled experimental diabetes induced by streptozotocin (STZ) in rats is an endogenous chronic stressor that produces retraction and simplification of apical dendrites of hippocampal CA3 pyramidal neurons, an effect also observed in nondiabetic rats after 21 d of repeated restraint stress or chronic corticosterone (Cort) treatment.	Corticosterone	328-342	carbonic anhydrase 3	Rattus norvegicus	210-213
11005876-1	2000	We report that 9 d of uncontrolled experimental diabetes induced by streptozotocin (STZ) in rats is an endogenous chronic stressor that produces retraction and simplification of apical dendrites of hippocampal CA3 pyramidal neurons, an effect also observed in nondiabetic rats after 21 d of repeated restraint stress or chronic corticosterone (Cort) treatment.	Corticosterone	344-348	carbonic anhydrase 3	Rattus norvegicus	210-213
11006443-3	2000	It was shown that in young rats under stress vasopressin (VP) is released into the portal circulation and probably in this way stimulates ACTH and enhances secretion of corticosterone in the adrenal cortex.	Corticosterone	169-183	arginine vasopressin	Rattus norvegicus	45-56
11006443-3	2000	It was shown that in young rats under stress vasopressin (VP) is released into the portal circulation and probably in this way stimulates ACTH and enhances secretion of corticosterone in the adrenal cortex.	Corticosterone	169-183	arginine vasopressin	Rattus norvegicus	58-60
10986362-4	2000	We presently studied the glucocorticoid feedback regulation of the expression of cholecystokinin (CCK) mRNA in rats after: (i) adrenalectomy, (ii) sham surgery or (iii) adrenalectomy with corticosterone replacement.	Corticosterone	188-202	cholecystokinin	Rattus norvegicus	81-96
10986362-8	2000	Adrenalectomy was shown to induce: (i) a 75% increase in CRH mRNA labeling in the PVN, (ii) a concomitant 43% decrease in CCK mRNA labeling but only in the anterior part of the PVN and occurring both in CCK/CRH area (two thirds of it) and CCK/OXY area (one third of it) and (iii) that they were fully reversed by corticosterone replacement.	Corticosterone	313-327	cholecystokinin	Rattus norvegicus	122-125
10980269-8	2000	The decrease in hippocampal glucocorticoid receptor mRNA expression occurs independently of circulating corticosterone since flesinoxan reduced glucocorticoid receptor mRNA in the hippocampus of adrenalectomized rats with or without corticosterone replacement.	Corticosterone	233-247	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	28-51
11052333-4	2000	The T3, T4, prolactin, and corticosterone alterations are associated with a persistent increase of TNF-alpha and NO, whose serum concentrations at 45 days postop are, respectively, 1838.33 +/- 247.07 vs 48.89 +/- 8.75 pg/ml and 0.43 +/- 0.13 vs 0.19 +/- 0.01 mmol/ml.	Corticosterone	27-41	tumor necrosis factor	Rattus norvegicus	99-108
11109028-1	2000	We examined whether the acute treatment with caffeine delivered before an ethanol injection would augment plasma corticosterone (CORT) levels.	Corticosterone	113-127	cortistatin	Rattus norvegicus	129-133
11051056-8	2000	It is concluded that elevated plasma corticosterone levels by downregulating GR during repeated swimming stress exerts beneficial effects in rats by retarding the total body weight gain and lowering plasma triglyceride levels without affecting free-radicals-induced oxidative stress.	Corticosterone	37-51	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	77-79
11211233-3	2000	In fact, at short times of exposure (2 h) a slight decrease in FGF-1 mRNA levels is induced by deoxycorticosterone, a steroid able to interact with the type I receptors; a similar effect is observed at 6 h following exposure to corticosterone or its 5alpha-reduced metabolite, dihydrocorticosterone.	Corticosterone	100-114	fibroblast growth factor 1	Rattus norvegicus	63-68
11211233-4	2000	Conversely, at longer times of exposure (24 h) corticosterone is able to strongly increase FGF-1 mRNA levels.	Corticosterone	47-61	fibroblast growth factor 1	Rattus norvegicus	91-96
11215154-4	2000	Repeated exposure to stress stimuli or chronic administration of corticosterone produces hippocampal 5-HT1A receptor dysfunction as well as an imbalance in mineralocorticoid and glucocorticoid receptors.	Corticosterone	65-79	5-hydroxytryptamine receptor 1A	Homo sapiens	101-116
10922080-7	2000	Plasma corticosterone levels after bacterial lipopolysaccharide injection in mice deficient in CRH or IL-6 were significantly lower than in wild-type mice but significantly greater than in mice deficient in both CRH and IL-6.	Corticosterone	7-21	corticotropin releasing hormone	Mus musculus	95-98
10922080-7	2000	Plasma corticosterone levels after bacterial lipopolysaccharide injection in mice deficient in CRH or IL-6 were significantly lower than in wild-type mice but significantly greater than in mice deficient in both CRH and IL-6.	Corticosterone	7-21	interleukin 6	Mus musculus	102-106
10922080-7	2000	Plasma corticosterone levels after bacterial lipopolysaccharide injection in mice deficient in CRH or IL-6 were significantly lower than in wild-type mice but significantly greater than in mice deficient in both CRH and IL-6.	Corticosterone	7-21	interleukin 6	Mus musculus	220-224
10903980-10	2000	Inhibitors of phospholipase C (PLC), protein kinase C (PKC), Ca(2+)/calmodulin-dependent protein kinase (CaMK) and antagonists of the L-type Ca(2+) channel also inhibit the corticosterone-induced gene transcription.	Corticosterone	173-187	calcium/calmodulin dependent protein kinase IV	Homo sapiens	61-103
10940488-10	2000	In contrast, corticosterone (10(-7)M) reduced leptin mRNA.	Corticosterone	13-27	leptin	Homo sapiens	46-52
10917320-1	2000	UNLABELLED: The authors have recently demonstrated that increased gene expression of glucose-6-phosphatase (Glu-6-Pase) in hemorrhagic hypotension (HH) and following lactated Ringer"s resuscitation (LR) is associated with a decrease in insulin and an increase in corticosterone concentrations.	Corticosterone	263-277	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	85-106
10917320-1	2000	UNLABELLED: The authors have recently demonstrated that increased gene expression of glucose-6-phosphatase (Glu-6-Pase) in hemorrhagic hypotension (HH) and following lactated Ringer"s resuscitation (LR) is associated with a decrease in insulin and an increase in corticosterone concentrations.	Corticosterone	263-277	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	108-118
10859269-6	2000	Subcutaneous implants of estradiol or corticosterone into lactating mice for 48 h stimulated adipose leptin secretion rates in vitro to the level of that in pregnant mice.	Corticosterone	38-52	leptin	Mus musculus	101-107
10859269-7	2000	However, corticosterone, but not estradiol, increased leptin secretion when added to isolated adipose tissue in vitro.	Corticosterone	9-23	leptin	Mus musculus	54-60
10859269-10	2000	We conclude that hyperleptinemia during late pregnancy in mice primarily results from corticosterone-dependent up-regulation of leptin secretion from adipose tissue, and that the placenta does not contribute to leptin secretion.	Corticosterone	86-100	leptin	Mus musculus	22-28
10859269-10	2000	We conclude that hyperleptinemia during late pregnancy in mice primarily results from corticosterone-dependent up-regulation of leptin secretion from adipose tissue, and that the placenta does not contribute to leptin secretion.	Corticosterone	86-100	leptin	Mus musculus	128-134
10875245-6	2000	For concentrations ranging from 10(-10) to 10(-5) M, synthetic frog neurotensin increased corticosterone and aldosterone production in a dose-dependent manner (EC50 = 1.2 x 10(-9) M and 5.8 x 10(-10) M, respectively).	Corticosterone	90-104	neurotensin	Canis lupus familiaris	68-79
10875245-8	2000	Prolonged administration (3 h) of frog neurotensin caused a transient increase in corticosterone and aldosterone secretion followed by a decline of corticosteroid secretion.	Corticosterone	82-96	neurotensin	Canis lupus familiaris	39-50
10912855-8	2000	CONCLUSION: The initial rise and subsequent decline in blood glucose correlate very well with a corticosterone-dependent induction of hepatic Glu-6-Pase, mRNA, and protein, followed by an insulin-dependent suppression of its expression.	Corticosterone	96-110	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	142-152
10854580-2	2000	By comparing GR immunoblot reactivity present in various tissue subcellular preparations we were able to discriminate between corticosterone-induced changes in GR activation or GR protein expression.	Corticosterone	126-140	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	13-15
10854580-2	2000	By comparing GR immunoblot reactivity present in various tissue subcellular preparations we were able to discriminate between corticosterone-induced changes in GR activation or GR protein expression.	Corticosterone	126-140	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	160-162
10854580-2	2000	By comparing GR immunoblot reactivity present in various tissue subcellular preparations we were able to discriminate between corticosterone-induced changes in GR activation or GR protein expression.	Corticosterone	126-140	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	160-162
10854580-5	2000	On the other hand, long-term adrenalectomy (3-14 days) resulted in a large increase in cytosolic GR, whereas acute (1-2 h) treatment with high dose corticosterone produced a large decrease in cytosolic GR.	Corticosterone	148-162	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	97-99
10854580-5	2000	On the other hand, long-term adrenalectomy (3-14 days) resulted in a large increase in cytosolic GR, whereas acute (1-2 h) treatment with high dose corticosterone produced a large decrease in cytosolic GR.	Corticosterone	148-162	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	202-204
10854580-6	2000	Western blot measurement of GR levels in a nuclear extract or whole-cell extract from the same brains indicated that acute corticosterone treatment produced a large increase in nuclear GR and no change in whole-cell GR.	Corticosterone	123-137	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	28-30
10854580-6	2000	Western blot measurement of GR levels in a nuclear extract or whole-cell extract from the same brains indicated that acute corticosterone treatment produced a large increase in nuclear GR and no change in whole-cell GR.	Corticosterone	123-137	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	185-187
10854580-6	2000	Western blot measurement of GR levels in a nuclear extract or whole-cell extract from the same brains indicated that acute corticosterone treatment produced a large increase in nuclear GR and no change in whole-cell GR.	Corticosterone	123-137	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	185-187
10854580-7	2000	Thus, all of the decrease in cytosolic GR observed after acute corticosterone treatment could be accounted for by receptor redistribution to the nuclear tissue fraction as opposed to rapid receptor protein downregulation.	Corticosterone	63-77	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	39-41
10854580-8	2000	Long-term treatment of rats with adrenalectomy or high dose corticosterone produced a large increase and decrease, respectively, in whole-cell GR, indicating genuine changes in receptor protein expression.	Corticosterone	60-74	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	143-145
10830310-3	2000	Exposure of rat anterior pituitary tissue to corticosterone (1 nM) or dexamethasone (100 nM) in vitro induced 1) de novo annexin 1 synthesis and 2) translocation of the protein from intracellular to pericellular sites.	Corticosterone	45-59	annexin A1	Rattus norvegicus	121-130
10830310-6	2000	The increases in PRL release induced in vitro by drugs that signal via cAMP/protein kinase A [vasoactive intestinal polypeptide (10 nM), forskolin (100 microM), 8-bromo-cAMP (0.1 microM)] or phospholipase C (TRH, 10 nM) were attenuated by preincubation of the pituitary tissue with either corticosterone (1 nM) or dexamethasone (100 nM).	Corticosterone	289-303	prolactin	Rattus norvegicus	17-20
10830310-9	2000	In vivo, interleukin-1beta (10 ng, intracerebroventricularly) produced a significant increase in the serum PRL concentration (P &lt; 0.01), which was prevented by pretreatment of the rats with corticosterone (100 microg/100 g BW, sc).	Corticosterone	193-207	interleukin 1 beta	Rattus norvegicus	9-26
10830310-9	2000	In vivo, interleukin-1beta (10 ng, intracerebroventricularly) produced a significant increase in the serum PRL concentration (P &lt; 0.01), which was prevented by pretreatment of the rats with corticosterone (100 microg/100 g BW, sc).	Corticosterone	193-207	prolactin	Rattus norvegicus	107-110
10844587-1	2000	In a previous study using corticosterone treatment of adrenalectomized rats, we hypothesized that mineralocorticoid receptor (MR)-related mechanisms are constitutively active and that glucocorticoid receptor (GR)-mediated mechanisms are more efficient in Brown Norway rats compared to Fischer 344 (F344) rats.	Corticosterone	26-40	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	98-124
10844587-1	2000	In a previous study using corticosterone treatment of adrenalectomized rats, we hypothesized that mineralocorticoid receptor (MR)-related mechanisms are constitutively active and that glucocorticoid receptor (GR)-mediated mechanisms are more efficient in Brown Norway rats compared to Fischer 344 (F344) rats.	Corticosterone	26-40	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	126-128
10925215-7	2000	Whereas administration of corticosterone significantly reduced the activity of 3beta-hydroxysteroid dehydrogenases (3beta-HSD) in granulosa and thecal cells, it reduced the activity of 17beta-HSD only in granulosa cells.	Corticosterone	26-40	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	79-114
10925215-7	2000	Whereas administration of corticosterone significantly reduced the activity of 3beta-hydroxysteroid dehydrogenases (3beta-HSD) in granulosa and thecal cells, it reduced the activity of 17beta-HSD only in granulosa cells.	Corticosterone	26-40	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	116-125
10925215-7	2000	Whereas administration of corticosterone significantly reduced the activity of 3beta-hydroxysteroid dehydrogenases (3beta-HSD) in granulosa and thecal cells, it reduced the activity of 17beta-HSD only in granulosa cells.	Corticosterone	26-40	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	185-195
10793089-6	2000	Fasting increased basal serum corticosterone; leptin treatment blunted this increase.	Corticosterone	30-44	leptin	Mus musculus	46-52
10793089-7	2000	Fasting decreased the ability of LPS to increase corticosterone; leptin restored the corticosterone response to LPS.	Corticosterone	85-99	leptin	Mus musculus	65-71
10921443-4	2000	Leptin administration to normal rats resulted in significant rises in the blood levels of ACTH, aldosterone and corticosterone at 2 h, but not at 4 h. Ether and cold stresses markedly increased hormonal blood concentrations at both 2 and 4 h. Leptin magnified ACTH response to ether stress at 2 h, but depressed it at 4 h, and enhanced aldosterone response at 2 h, without affecting corticosterone response.	Corticosterone	112-126	leptin	Rattus norvegicus	0-6
10921443-4	2000	Leptin administration to normal rats resulted in significant rises in the blood levels of ACTH, aldosterone and corticosterone at 2 h, but not at 4 h. Ether and cold stresses markedly increased hormonal blood concentrations at both 2 and 4 h. Leptin magnified ACTH response to ether stress at 2 h, but depressed it at 4 h, and enhanced aldosterone response at 2 h, without affecting corticosterone response.	Corticosterone	383-397	leptin	Rattus norvegicus	0-6
10921443-4	2000	Leptin administration to normal rats resulted in significant rises in the blood levels of ACTH, aldosterone and corticosterone at 2 h, but not at 4 h. Ether and cold stresses markedly increased hormonal blood concentrations at both 2 and 4 h. Leptin magnified ACTH response to ether stress at 2 h, but depressed it at 4 h, and enhanced aldosterone response at 2 h, without affecting corticosterone response.	Corticosterone	383-397	leptin	Rattus norvegicus	243-249
10890568-7	2000	[3H]Corticosterone also bound to presumed CBG in plasma with high affinity (Kd approximately 2.7 nM), but dexamethasone and androgens bound to plasma CBG with equivalently high affinity.	Corticosterone	4-18	serpin family A member 6	Homo sapiens	42-45
10900249-5	2000	and s.c. administration, LY426965 blocked the lower lip retraction, flat body posture, hypothermia, and increase in rat serum corticosterone induced by the 5-HT(1A) agonist 8-OH-DPAT (8-hydroxy-2-dipropylaminotetralin).	Corticosterone	126-140	5-hydroxytryptamine receptor 1A	Homo sapiens	156-163
10871301-3	2000	We systematically examined the relationship of altered HPA function with PKA modifications in rat brain after administering corticosterone to normal rats and by first adrenalectomizing rats and then simultaneously treating them with different doses of corticosterone.	Corticosterone	124-138	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	73-76
10871301-3	2000	We systematically examined the relationship of altered HPA function with PKA modifications in rat brain after administering corticosterone to normal rats and by first adrenalectomizing rats and then simultaneously treating them with different doses of corticosterone.	Corticosterone	252-266	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	73-76
10871301-5	2000	Subcutaneously implanted 50- or 100-mg corticosterone pellets in normal rats for 4 or 14 days significantly decreased PKA activity, B(max) of [3H]cyclic AMP binding, and protein levels of selective PKA regulatory (RIalpha, RIIbeta) and catalytic (Catbeta) subunit isoforms in cortex and hippocampus in a dose-dependent manner without any significant changes at day 1; these changes were more pronounced at day 14.	Corticosterone	39-53	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	118-121
10871301-5	2000	Subcutaneously implanted 50- or 100-mg corticosterone pellets in normal rats for 4 or 14 days significantly decreased PKA activity, B(max) of [3H]cyclic AMP binding, and protein levels of selective PKA regulatory (RIalpha, RIIbeta) and catalytic (Catbeta) subunit isoforms in cortex and hippocampus in a dose-dependent manner without any significant changes at day 1; these changes were more pronounced at day 14.	Corticosterone	39-53	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	198-201
10871301-7	2000	Simultaneous treatment with implanted corticosterone at 50- or 100-mg doses in adrenalectomized rats reversed the adrenalectomy-induced increases in PKA measures in a dose-dependent manner.	Corticosterone	38-52	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	149-152
10865230-16	2000	Since glucocorticoids decrease at night in humans at the time of the maximum plasma concentrations of leptin, we hypothesize that this increase in leptin from a relatively high dose of DEX would mimic the response to the release of corticosterone following stress in the rat and that glucocorticoids are not responsible for the circadian rhythm of leptin concentration.	Corticosterone	232-246	leptin	Homo sapiens	102-108
10865230-16	2000	Since glucocorticoids decrease at night in humans at the time of the maximum plasma concentrations of leptin, we hypothesize that this increase in leptin from a relatively high dose of DEX would mimic the response to the release of corticosterone following stress in the rat and that glucocorticoids are not responsible for the circadian rhythm of leptin concentration.	Corticosterone	232-246	leptin	Homo sapiens	147-153
10865230-16	2000	Since glucocorticoids decrease at night in humans at the time of the maximum plasma concentrations of leptin, we hypothesize that this increase in leptin from a relatively high dose of DEX would mimic the response to the release of corticosterone following stress in the rat and that glucocorticoids are not responsible for the circadian rhythm of leptin concentration.	Corticosterone	232-246	leptin	Rattus norvegicus	147-153
10843673-3	2000	Here we report that activation of T cells either by plate-bound mAb (anti-TCR, anti-CD3) or soluble activators (staphylococcal enterotoxin A, Con A) is associated with an (up to 3-fold) increase in CD4 cell surface expression on CD25+ cells, which was maximal after 72-96 h. Incubation with the glucocorticoid hormone corticosterone (CORT) shifted the enhancement of CD4 expression to a point about 24 h earlier than that observed in control cultures.	Corticosterone	318-332	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	74-77
10843673-3	2000	Here we report that activation of T cells either by plate-bound mAb (anti-TCR, anti-CD3) or soluble activators (staphylococcal enterotoxin A, Con A) is associated with an (up to 3-fold) increase in CD4 cell surface expression on CD25+ cells, which was maximal after 72-96 h. Incubation with the glucocorticoid hormone corticosterone (CORT) shifted the enhancement of CD4 expression to a point about 24 h earlier than that observed in control cultures.	Corticosterone	318-332	CD4 molecule	Homo sapiens	198-201
10844602-7	2000	RESULTS: Short-term exposure of VSMCs to CORTI (10-6 mol/L) increased NHE activity, whereas long-term exposure to CORTI decreased it.	Corticosterone	41-46	solute carrier family 9 member A1	Rattus norvegicus	70-73
10844602-9	2000	The cytosolic GC receptor (GR) antagonist (RU38486) inhibited both the short- and long-term effects of CORTI on NHE activity, but the cytosolic mineralocorticoid receptor antagonist (spironolactone) did not influence either the short- or long-term CORTI effects.	Corticosterone	103-108	solute carrier family 9 member A1	Rattus norvegicus	112-115
10878498-11	2000	These results suggest that intracerebroventricular leptin administration activates the HPA axis by AVP receptor activation through V(1a) receptors in the PVN which in turn activates CRH neurons to drive ACTH and corticosterone secretion in concert with AVP in nonstrained rats.	Corticosterone	212-226	corticotropin releasing hormone	Rattus norvegicus	182-185
10880674-0	2000	Chronic corticosterone impairs inhibitory avoidance in rats: possible link with atrophy of hippocampal CA3 neurons.	Corticosterone	8-22	carbonic anhydrase 3	Rattus norvegicus	103-106
10913780-8	2000	Peak levels of plasma corticosterone were coincident with peak PPE mRNA levels.	Corticosterone	22-36	proenkephalin	Homo sapiens	63-66
10913780-9	2000	Adrenalectomy plus a constant, low level of corticosterone eliminated the injection-induced increase of corticosterone levels and the subsequent increase in PPE mRNA expression in the ventromedial hypothalamic nucleus and posterodorsal medial amygdala.	Corticosterone	44-58	proenkephalin	Homo sapiens	157-160
10781002-15	2000	LPS pretreatment increased serum corticosterone levels in both mice, while it increased the serum nitrate/nitrite levels in wild-type but not in iNOS deficient mice.	Corticosterone	33-47	toll-like receptor 4	Mus musculus	0-3
10792576-1	2000	In rats, circulating corticosterone and insulin are involved in regulation of the hypothalamic neuropeptide Y (NPY) system, which in turn, is involved in regulation of the hypothalamic-pituitary-adrenal (HPA) axis.	Corticosterone	21-35	neuropeptide Y	Rattus norvegicus	95-109
10792576-1	2000	In rats, circulating corticosterone and insulin are involved in regulation of the hypothalamic neuropeptide Y (NPY) system, which in turn, is involved in regulation of the hypothalamic-pituitary-adrenal (HPA) axis.	Corticosterone	21-35	neuropeptide Y	Rattus norvegicus	111-114
10792576-5	2000	Adrenalectomized rats with systemic corticosterone replacement (ADX+CORT), whose corticosterone concentration was maintained at approximately 50-100 ng/ml during repeated stress, showed a decrease in plasma insulin and an increase in arcuate nucleus NPY mRNA similar to that observed in sham rats, suggesting that changes in NPY mRNA levels are more closely tied to circulating insulin than to circulating corticosterone.	Corticosterone	36-50	neuropeptide Y	Rattus norvegicus	250-253
10792576-5	2000	Adrenalectomized rats with systemic corticosterone replacement (ADX+CORT), whose corticosterone concentration was maintained at approximately 50-100 ng/ml during repeated stress, showed a decrease in plasma insulin and an increase in arcuate nucleus NPY mRNA similar to that observed in sham rats, suggesting that changes in NPY mRNA levels are more closely tied to circulating insulin than to circulating corticosterone.	Corticosterone	36-50	neuropeptide Y	Rattus norvegicus	325-328
10822027-7	2000	These results suggest that prolonged ACTH treatment increases oxidative stress in the zona glomerulosa and an imbalance in the ratio of Mn-SOD to GPx, possibly via corticosterone overproduction in the zona fasciculata, resulting in the downregulation of CYP11B2.	Corticosterone	164-178	superoxide dismutase 2	Rattus norvegicus	136-142
10800959-9	2000	Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats.	Corticosterone	115-129	interleukin 1 beta	Rattus norvegicus	50-58
10800959-9	2000	Both intracerebroventricular PGE2 and intravenous IL-1beta injection provoked a sharp and rapid increase in plasma corticosterone levels, an effect that was completely prevented in inhibiting PG production in IL-1beta-challenged rats.	Corticosterone	115-129	interleukin 1 beta	Rattus norvegicus	209-217
10822027-7	2000	These results suggest that prolonged ACTH treatment increases oxidative stress in the zona glomerulosa and an imbalance in the ratio of Mn-SOD to GPx, possibly via corticosterone overproduction in the zona fasciculata, resulting in the downregulation of CYP11B2.	Corticosterone	164-178	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	254-261
10938581-0	2000	Corticosterone effects on BDNF expression in the hippocampus.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	26-30
10938581-4	2000	In this review, the question is addressed if the corticosterone effects on memory processes are mediated by alterations in the expression of the neurotrophin Brain-Derived Neurotrophic Factor (BDNF) in the hippocampus.	Corticosterone	49-63	brain-derived neurotrophic factor	Rattus norvegicus	193-197
10938581-5	2000	First, studies are described investigating the effect of corticosterone on BDNF expression in the rat hippocampus.	Corticosterone	57-71	brain-derived neurotrophic factor	Rattus norvegicus	75-79
10938581-6	2000	It appears that corticosterone suppresses the BDNF expression at the mRNA and protein level in a subfield-specific way.	Corticosterone	16-30	brain-derived neurotrophic factor	Rattus norvegicus	46-50
10938581-12	2000	Therefore, we suggest that the resistance of the hippocampal BDNF expression to suppression by corticosterone, as seen after water maze training, may contribute to an optimal memory performance.	Corticosterone	95-109	brain-derived neurotrophic factor	Rattus norvegicus	61-65
10760490-0	2000	Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	50-80
10760490-5	2000	Corticosterone implants increased indices of anxiety on the elevated plus-maze and produced a concomitant increase in both basal level of CRF mRNA per neuron and the number of neurons with CRF hybridization signal in the CeA.	Corticosterone	0-14	carcinoembryonic antigen gene family 4	Rattus norvegicus	221-224
10733946-3	2000	The level of corticosterone increased in a dose-dependent manner 15 min after icv injection of orexin, and it remained high for at least 60 min.	Corticosterone	13-27	hypocretin neuropeptide precursor	Rattus norvegicus	95-101
10715576-7	2000	In particular, we evidence an inhibitory influence of corticosterone on PSA-NCAM expression.	Corticosterone	54-68	neural cell adhesion molecule 1	Mus musculus	76-80
10727270-1	2000	The 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) enzyme catalyses the conversion of the biologically inert glucocorticoid 11-dehydrocorticosterone to active corticosterone (11-oxoreductase activity) in vivo, and it is dramatically up-regulated in uterine myometrium in the days leading up to parturition.	Corticosterone	145-159	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	4-60
10742107-6	2000	Crhr2 also appears to modify the recovery phase of the HPA response, as corticosterone levels remain elevated 90 minutes after stress in Crhr2-/- mice.	Corticosterone	72-86	corticotropin releasing hormone receptor 2	Mus musculus	0-5
10777776-5	2000	In Northern blots, PMCA1 was repressed approximately 33% after a high, but not a low dose of the GC, corticosterone (B), suggesting glucocorticoid (but not mineralocorticoid) receptor-mediated repression.	Corticosterone	101-115	ATPase plasma membrane Ca2+ transporting 1	Rattus norvegicus	19-24
10760069-5	2000	However, when corticosterone was administered along with a 11beta-HSD2 inhibitor, a strong Na+ transport was elicited by an MR-mediated mechanism.	Corticosterone	14-28	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	59-70
10720073-4	2000	However, CYP11B2-D147E caused a significant increase in corticosterone production and a smaller increase in aldosterone production from 11-deoxycorticosterone (DOC).	Corticosterone	56-70	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	9-16
10698191-4	2000	Adrenal corticosterone content tended to increase in CRH KO mice, although to levels 5-fold lower than that in WT mice.	Corticosterone	8-22	corticotropin releasing hormone	Mus musculus	53-56
10795920-6	2000	Osmotically stimulated vasopressin release is also blocked by testosterone, dihydrotestosterone, oestradiol and corticosterone.	Corticosterone	112-126	arginine vasopressin	Rattus norvegicus	23-34
10720073-7	2000	The reverse construct (CYP11B1-E147D), substituting the 11beta-hydroxylase residue with the aldosterone synthase equivalent, decreased the conversion of DOC to corticosterone, which was mediated by an increase in Km that was 7.5 micromol/L for the mutant compared with 2.5 micromol/L for the wild-type enzyme.	Corticosterone	160-174	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	92-112
10718920-0	2000	Transcriptional repression of the 5-HT1A receptor promoter by corticosterone via mineralocorticoid receptors depends on the cellular context.	Corticosterone	62-76	5-hydroxytryptamine receptor 1A	Homo sapiens	34-49
10712435-9	2000	Chronically elevated serum LH, augmented by enhanced PRL production, induces functional LHR expression in mouse adrenal cortex, leading to elevated, LH-dependent, corticosterone production.	Corticosterone	163-177	prolactin	Mus musculus	53-56
10712435-9	2000	Chronically elevated serum LH, augmented by enhanced PRL production, induces functional LHR expression in mouse adrenal cortex, leading to elevated, LH-dependent, corticosterone production.	Corticosterone	163-177	luteinizing hormone/choriogonadotropin receptor	Mus musculus	88-91
10684907-5	2000	Apoe(-/-) mice, which develop neurodegenerative alterations as they age, had an age-dependent increase in basal adrenal corticosterone content and abnormally increased plasma corticosterone levels after restraint stress, whereas their plasma and pituitary adrenocorticotropin levels were either unchanged or lower than those in controls.	Corticosterone	120-134	apolipoprotein E	Mus musculus	0-4
10684907-5	2000	Apoe(-/-) mice, which develop neurodegenerative alterations as they age, had an age-dependent increase in basal adrenal corticosterone content and abnormally increased plasma corticosterone levels after restraint stress, whereas their plasma and pituitary adrenocorticotropin levels were either unchanged or lower than those in controls.	Corticosterone	175-189	apolipoprotein E	Mus musculus	0-4
10718920-3	2000	The 5-HT1A receptor, for example, is highly expressed in the hippocampus and raphe but transcription is repressed by corticosterone (the principal glucocorticoid in rodents) only in hippocampus.	Corticosterone	117-131	5-hydroxytryptamine receptor 1A	Homo sapiens	4-19
11261595-3	2000	BNP did not modify the basal secretion, but inhibited the stress-induced rise in plasma corticosterone in a dose-dependent manner.	Corticosterone	88-102	natriuretic peptide B	Rattus norvegicus	0-3
11261595-4	2000	BNP proved most effective in decreasing the corticosterone response to ether stress and attenuated the electric shock and restraint-induced HPA activation to a lesser extent.	Corticosterone	44-58	natriuretic peptide B	Rattus norvegicus	0-3
10949112-1	2000	The objective of the present study was to investigate whether repeated exposure of rats to high level of corticosterone affects responses of CA1 hippocampal cells to the 5-HT4 receptor agonist zacopride.	Corticosterone	105-119	carbonic anhydrase 1	Rattus norvegicus	141-144
10775807-7	2000	LH plus corticosterone treatment did not affect 3beta-HSD activity but decreased 17beta-HSD activity, indicating a direct inhibitory effect of excess corticosterone on Leydig cell testosterone synthesis.	Corticosterone	8-22	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	81-91
10775807-8	2000	The indirect effect of corticosterone, thus, assume to be mediated through lower LH which regulates the activity of 3beta-HSD.	Corticosterone	23-37	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	116-125
10949112-5	2000	It is concluded that repeated treatment with corticosterone increases the responsiveness of hippocampal CA1 neurons to the 5-HT4 receptor activation.	Corticosterone	45-59	carbonic anhydrase 1	Rattus norvegicus	104-107
10650957-2	2000	The finding that intracerebroventricular GLP-1 stimulates LH, TSH, corticosterone, and vasopressin secretion in rats prompted us to assess the neuroendocrine consequences of disrupting GLP-1 signaling in mice in vivo.	Corticosterone	67-81	glucagon	Rattus norvegicus	41-46
10737420-2	2000	Exogenous administration of corticosterone or metapyrone for 6 days inhibited adrenal delta5-3beta(delta 5-3 beta) hydroxysteroid (delta5-3beta-HSD) and testicular 17beta (17 beta) hydroxysteroid dehydrogenase (17beta-HSD) activities, decreased the serum levels of testosterone and inhibited spermatogenesis.	Corticosterone	28-42	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	211-221
10666137-6	2000	Finally, we demonstrated that pretreatment with the glucocorticoid receptor antagonist RU-486 blocks the delay in barrier recovery produced by systemic corticosterone, change of cage, or immobilization.	Corticosterone	152-166	nuclear receptor subfamily 3, group C, member 1	Mus musculus	52-75
10650957-5	2000	Intriguingly, GLP-1R-/- mice exhibit paradoxically increased corticosterone responses to stress as well as abnormal responses to acoustic startle that are corrected by glucocorticoid treatment.	Corticosterone	61-75	glucagon-like peptide 1 receptor	Mus musculus	14-20
10711727-5	2000	Leptin[1-147] increased plasma aldosterone concentration at day 8 and plasma corticosterone concentration (PBC) at day 5 of regeneration, without affecting mitotic index.	Corticosterone	77-91	leptin	Rattus norvegicus	0-6
10650962-11	2000	CART caused a strong increase in circulating corticosterone that was significantly different from saline at 20, 40, 60, and 120 min postinjection (P&lt;0.05).	Corticosterone	45-59	CART prepropeptide	Rattus norvegicus	0-4
10650962-17	2000	CART on corticosterone and oxytocin secretion is caused by activation of paraventricular nucleus/supraoptic nucleus (PVN/SON) neuroendocrine neurons, we used c-Fos as a marker of neuronal activity.	Corticosterone	8-22	CART prepropeptide	Rattus norvegicus	0-4
10650962-23	2000	The effect of CART on CRH neurons most likely leads to corticosterone secretion from the adrenal gland, which may contribute to the inhibitory effects of CART on feeding behavior.	Corticosterone	55-69	CART prepropeptide	Rattus norvegicus	14-18
10650962-23	2000	The effect of CART on CRH neurons most likely leads to corticosterone secretion from the adrenal gland, which may contribute to the inhibitory effects of CART on feeding behavior.	Corticosterone	55-69	corticotropin releasing hormone	Rattus norvegicus	22-25
10650962-23	2000	The effect of CART on CRH neurons most likely leads to corticosterone secretion from the adrenal gland, which may contribute to the inhibitory effects of CART on feeding behavior.	Corticosterone	55-69	CART prepropeptide	Rattus norvegicus	154-158
10686522-1	2000	We have previously observed significant, albeit decreased, corticosterone responses to restraint stress in corticotropin releasing hormone (CRH)-deficient (knockout, CRH KO) mice.	Corticosterone	59-73	corticotropin releasing hormone	Mus musculus	107-138
10642748-2	2000	GFAP staining in the SCN was significantly higher in rats having received implants that restored physiological plasma levels of corticosterone within diurnal or nocturnal limits than in non-normalized rats.	Corticosterone	128-142	glial fibrillary acidic protein	Rattus norvegicus	0-4
10642748-3	2000	The effects of corticosterone were similar in the parvocellular portion of the paraventricular nucleus but were opposite in the hippocampus, another major site of negative feed-back regulation of the hypothalamic-pituitary-adrenal axis, where a decreased GFAP staining was observed in discrete regions of the dentate gyrus.	Corticosterone	15-29	glial fibrillary acidic protein	Rattus norvegicus	255-259
10642748-6	2000	It is proposed that the corticosterone-induced increase in GFAP staining in that nucleus accounts for dynamic changes in neurone-astrocyte interactions that might occur in relation with natural fluctuations of glucocorticoids over the 24 h period.	Corticosterone	24-38	glial fibrillary acidic protein	Rattus norvegicus	59-63
10686522-1	2000	We have previously observed significant, albeit decreased, corticosterone responses to restraint stress in corticotropin releasing hormone (CRH)-deficient (knockout, CRH KO) mice.	Corticosterone	59-73	corticotropin releasing hormone	Mus musculus	140-143
10686522-3	2000	Insulin injection in fasted CRH KO mice elicited increases in corticosterone that were markedly lower than those in wild type but marginally significant relative to corresponding KO controls.	Corticosterone	62-76	corticotropin releasing hormone	Mus musculus	28-31
10686522-5	2000	Hypovolemia produced by retro-orbital bleeding also significantly elevated corticosterone in CRH KO mice.	Corticosterone	75-89	corticotropin releasing hormone	Mus musculus	93-96
10686522-8	2000	CRH infusion enhanced adrenocortical responses to restraint independently of effects on basal corticosterone levels, suggesting that pituitary-adrenal activity is augmented by factors besides CRH during stress.	Corticosterone	94-108	corticotropin releasing hormone	Mus musculus	0-3
10607912-0	2000	Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression.	Corticosterone	128-142	heme oxygenase 2	Rattus norvegicus	60-76
10810451-5	2000	Kd and Bmax values of 0.646 and 578 nM for corticosterone binding to rat CBG and 0.577 and 19.8 nM for cortisol binding to sheep CBG, respectively, were measured.	Corticosterone	43-57	serpin family A member 6	Rattus norvegicus	73-76
10607912-5	2000	In this study, we have examined the structural basis for size heterogeneity of HO-2 transcripts and whether expression of HO-2 at mRNA and protein levels is subject to regulation by corticosterone.	Corticosterone	182-196	heme oxygenase 2	Rattus norvegicus	122-126
10607912-15	2000	Treatment of newborn rats with corticosterone for 5days, starting on day 2 after birth, induced HO-2 protein expression in the testis as detected by Western blotting.	Corticosterone	31-45	heme oxygenase 2	Rattus norvegicus	96-100
10626669-4	2000	The purpose of the present study was to evaluate whether chronic administration of G-CSF affects ACTH and corticosterone secretion and growth processes of the rat anterior pituitary gland and adrenal cortex in vivo.	Corticosterone	106-120	colony stimulating factor 2	Rattus norvegicus	83-88
10626669-5	2000	We have demonstrated that G-CSF (at a dose of 10.0 microg/kg body weight (BW)) injected s.c. once daily (for 7 days), stimulated both ACTH and corticosterone secretion.	Corticosterone	143-157	colony stimulating factor 2	Rattus norvegicus	26-31
10670429-6	2000	Basal corticosterone (CORT) levels (NT group) were consistently higher in periadolescents than in adults.	Corticosterone	6-20	cortistatin	Mus musculus	22-26
10614640-4	2000	Pretreatment of adrenal cells with the protein kinase A inhibitor H-89 markedly reduced the stimulatory effect of TTN on corticosterone and aldosterone secretion by perifused cells, whereas the phospholipase C inhibitor U-73122 did not affect the TTN-evoked stimulation of corticosteroid output.	Corticosterone	121-135	TTN	Canis lupus familiaris	114-117
11268391-4	2000	Exposure to IL-6 increases cortisol or corticosterone release from human, bovine, and rat adrenal cells.	Corticosterone	39-53	interleukin 6	Homo sapiens	12-16
11268391-7	2000	TNF alpha inhibits corticosterone release from normal rat adrenal cells or fragments, but increases corticosterone release from cholestatic rat adrenal slices.	Corticosterone	19-33	tumor necrosis factor	Rattus norvegicus	0-9
11268391-7	2000	TNF alpha inhibits corticosterone release from normal rat adrenal cells or fragments, but increases corticosterone release from cholestatic rat adrenal slices.	Corticosterone	100-114	tumor necrosis factor	Rattus norvegicus	0-9
10617155-0	2000	Evaluation of apoptosis and the glucocorticoid receptor in the cartilage growth plate and metaphyseal bone cells of rats after high-dose treatment with corticosterone.	Corticosterone	152-166	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	32-55
10719064-0	2000	Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1beta protein response to acute stress.	Corticosterone	15-29	interleukin 1 beta	Homo sapiens	77-94
10719064-4	2000	A prior report indicated that exposure to inescapable tailshocks (IS) raised levels of brain IL-1beta protein 2 h after IS, but only in adrenalectomized (and basal corticosterone replaced) subjects.	Corticosterone	164-178	interleukin 1 beta	Homo sapiens	93-101
10719064-10	2000	Finally, the administration of corticosterone in an amount that led to blood levels in adrenalectomized subjects that match those produced by IS, inhibited the IS-induced rise in IL-1beta in hypothalamus and pituitary, but not in other brain regions or blood.	Corticosterone	31-45	interleukin 1 beta	Homo sapiens	179-187
10859487-5	2000	METHODS: We have therefore examined the ACTH and corticosterone responses to IL-6 in intact and castrated male rats with and without testosterone replacement.	Corticosterone	49-63	interleukin 6	Rattus norvegicus	77-81
10794493-6	2000	In in vivo studies the degree of thymic atrophy and the increases in serum level of ACTH and corticosterone induced by intraperitoneal IL-1beta injection were much less in STR/N mice than those in controls.	Corticosterone	93-107	interleukin 1 beta	Mus musculus	135-143
10810249-5	2000	In the latter, serum corticosterone (Cort) was also estimated.	Corticosterone	21-35	cortistatin	Rattus norvegicus	37-41
10859481-0	2000	Modulation of IL-18 production in the adrenal cortex following acute ACTH or chronic corticosterone treatment.	Corticosterone	85-99	interleukin 18	Rattus norvegicus	14-19
10859481-3	2000	In order to investigate the mechanisms governing the expression of IL-18 in the adrenal cortex, the effects of acute ACTH or chronic corticosterone treatment on the levels of IL-18 mRNA and protein were examined by in situ hybridization and Northern and Western blot assays.	Corticosterone	133-147	interleukin 18	Rattus norvegicus	175-180
10859481-6	2000	Six days of chronic corticosterone treatment did not alter the basal levels of IL-18 mRNA and reduced those of pro-IL-18.	Corticosterone	20-34	interleukin 18	Rattus norvegicus	115-120
10859481-7	2000	Finally, ACTH treatment of animals under the corticosterone regimen induced a 2-fold increase in IL-18 mRNA and elevated the levels of the pro-IL-18 protein.	Corticosterone	45-59	interleukin 18	Rattus norvegicus	97-102
10859481-7	2000	Finally, ACTH treatment of animals under the corticosterone regimen induced a 2-fold increase in IL-18 mRNA and elevated the levels of the pro-IL-18 protein.	Corticosterone	45-59	interleukin 18	Rattus norvegicus	143-148
10716540-2	2000	The modified multiple platform method (MMPM), in which animals are placed with new cohorts inside the water tanks, results in augmented ACTH and corticosterone (CORT) responses.	Corticosterone	145-159	cortistatin	Rattus norvegicus	161-165
10611376-7	1999	The COX-2 up-regulation in ADX rats was reversed by replacement therapy with either corticosterone or deoxycorticosterone acetate.	Corticosterone	84-98	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	4-9
10799757-6	2000	Consistent with previous findings, dendritic atrophy was observed in the CA3 hippocampal region of chronically stressed and corticosterone-treated rats; in addition, we observed atrophy in granule and CA1 pyramidal cells following these treatments.	Corticosterone	124-138	carbonic anhydrase 1	Rattus norvegicus	201-204
27414052-1	2000	Neuropeptide Y (NPY), insulin, corticosterone (CORT) and 5-hydroxytryptamine (5-HT), or serotonin, are all involved in energy homeostasis.	Corticosterone	31-45	cortistatin	Rattus norvegicus	47-51
10941273-6	2000	Moreover, repeated corticosterone, which may constitute a model of a prolonged nonadaptable stress, has opposite effect on hippocampal responsiveness to the 5-HT1A and 5-HT4 receptor activation.	Corticosterone	19-33	5-hydroxytryptamine receptor 1A	Homo sapiens	157-182
11155801-2	2000	For example, it has been shown that IL-1 is the main mediator of the increase in ACTH and corticosterone blood levels detected in models of viral infection and bacterial endotoxins.	Corticosterone	90-104	interleukin 1 alpha	Homo sapiens	36-40
10591145-6	1999	We found that corticosterone and dexamethasone affected polyamine oxidase activity in both tissues, with an opposite dose-dependent effect of the natural hormone in the thymus.	Corticosterone	14-28	polyamine oxidase	Rattus norvegicus	56-73
10591145-7	1999	The decrease and increase in polyamine oxidase after the two doses of corticosterone were correlated with the absence and the occurrence of DNA fragmentation, respectively.	Corticosterone	70-84	polyamine oxidase	Rattus norvegicus	29-46
10591145-8	1999	Moreover, corticosterone affected polyamine oxidase activity earlier (8 hr) than dexamethasone (24 hr), but the synthetic hormone was more efficient than the natural hormone in thymic polyamine depletion.	Corticosterone	10-24	polyamine oxidase	Rattus norvegicus	34-51
10600221-5	1999	MRL lpr/lpr) resulted in altered expression of HPA regulatory peptides at the level of the hypothalamus and how these alterations related to circulating levels of corticosterone, corticosterone binding globulin, and autoantibody titers.	Corticosterone	163-177	Fas (TNF receptor superfamily member 6)	Mus musculus	4-7
10600221-5	1999	MRL lpr/lpr) resulted in altered expression of HPA regulatory peptides at the level of the hypothalamus and how these alterations related to circulating levels of corticosterone, corticosterone binding globulin, and autoantibody titers.	Corticosterone	163-177	Fas (TNF receptor superfamily member 6)	Mus musculus	8-11
10600221-5	1999	MRL lpr/lpr) resulted in altered expression of HPA regulatory peptides at the level of the hypothalamus and how these alterations related to circulating levels of corticosterone, corticosterone binding globulin, and autoantibody titers.	Corticosterone	179-193	Fas (TNF receptor superfamily member 6)	Mus musculus	4-7
10600221-5	1999	MRL lpr/lpr) resulted in altered expression of HPA regulatory peptides at the level of the hypothalamus and how these alterations related to circulating levels of corticosterone, corticosterone binding globulin, and autoantibody titers.	Corticosterone	179-193	Fas (TNF receptor superfamily member 6)	Mus musculus	8-11
10859487-9	2000	RESULTS: IL-6 stimulated ACTH and corticosterone release in all groups, with peak stimulation occurring within the first hour.	Corticosterone	34-48	interleukin 6	Rattus norvegicus	9-13
10700082-13	1999	Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h. CONCLUSIONS: The first peak of catecholamine and corticosterone levels might result from unspecific stressor associated with the surgery.	Corticosterone	194-208	phenylethanolamine-N-methyltransferase	Rattus norvegicus	8-47
10579329-7	1999	Finally, sc injection of corticosterone stimulated Ucn mRNA comparably to that of LPS.	Corticosterone	25-39	urocortin	Rattus norvegicus	51-54
10579329-8	1999	Together, these results suggest that Ucn mRNA expression can increase after immune activation in a corticosterone-dependent manner, and that such changes in Ucn mRNA may be an additional consequence of HPA axis activation.	Corticosterone	99-113	urocortin	Rattus norvegicus	37-40
10700082-13	1999	Adrenal phenylethanolamine N-methyl-transferase (PNMT) mRNA levels were increased 4 h after both the PH and laparotomy and declined within 24 h. CONCLUSIONS: The first peak of catecholamine and corticosterone levels might result from unspecific stressor associated with the surgery.	Corticosterone	194-208	phenylethanolamine-N-methyltransferase	Rattus norvegicus	49-53
10938578-0	1999	Corticosterone effects on BDNF mRNA expression in the rat hippocampus during morris water maze training.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	26-30
10589508-3	1999	Administration of corticosterone 30 min prior to an ovine CRH (oCRH) challenge diminished the in vivo sensitivity of thyrotrophs to oCRH in 19-day-old chicken embryos (E19) (20 micrograms corticosterone; 2 micrograms oCRH) but not in 8-day-old chickens (C8) (40 micrograms corticosterone; 4 micrograms oCRH).	Corticosterone	18-32	corticotropin releasing hormone	Gallus gallus	58-61
10593197-6	1999	Corticotropin-releasing factor (CRF) antagonists were more effective at reducing ACTH compared to corticosterone levels.	Corticosterone	98-112	corticotropin releasing hormone	Rattus norvegicus	0-30
10938578-2	1999	In the present study we have investigated the effect of corticosterone on hippocampal BDNF mRNA expression after training in the Morris water maze in young adult Wistar rats.	Corticosterone	56-70	brain-derived neurotrophic factor	Rattus norvegicus	86-90
10938578-3	1999	Therefore, we first studied BDNF mRNA levels in the hippocampus in relation to corticosterone levels at several time points after 4 training trials in the Morris water maze.	Corticosterone	79-93	brain-derived neurotrophic factor	Rattus norvegicus	28-32
10938578-5	1999	However, in a previous study we observed dramatically decreased hippocampal BDNF mRNA levels in dentate gyrus and CA1 at 3 hr after injection of corticosterone.	Corticosterone	145-159	brain-derived neurotrophic factor	Rattus norvegicus	76-80
10938578-5	1999	However, in a previous study we observed dramatically decreased hippocampal BDNF mRNA levels in dentate gyrus and CA1 at 3 hr after injection of corticosterone.	Corticosterone	145-159	carbonic anhydrase 1	Rattus norvegicus	114-117
10938578-6	1999	In order to analyze this discrepancy, we subsequently investigated if hippocampal BDNF mRNA expression is affected by corticosterone at 3 hr after water maze training.	Corticosterone	118-132	brain-derived neurotrophic factor	Rattus norvegicus	82-86
10938578-9	1999	Furthermore, ADX animals which were injected with corticosterone showed decreased BDNF mRNA levels in all hippocampal regions compared to control ADX animals.	Corticosterone	50-64	brain-derived neurotrophic factor	Rattus norvegicus	82-86
10938578-12	1999	Hence, our results suggest that in this situation BDNF is resistant to regulation by endogenous corticosterone, which may be important for learning and memory processes.	Corticosterone	96-110	brain-derived neurotrophic factor	Rattus norvegicus	50-54
10564730-2	1999	Following a single in vivo injection of rats with corticosterone or the Type II glucocorticoid receptor agonist, RU-28362, synthesis of a 28 kDa protein is elevated in cerebellar slices which are subsequently incubated in vitro at 39 degrees C for 3 h. Immunoblotting of proteins subsequent to separation by two-dimensional gel electrophoresis has identified this glucocorticoid-sensitive protein to be the small molecular weight heat-shock protein, HSP27.	Corticosterone	50-64	heat shock protein family B (small) member 1	Rattus norvegicus	450-455
10559417-0	1999	Expression of alpha(1b) adrenoceptor mRNA in corticotropin-releasing hormone-containing cells of the rat hypothalamus and its regulation by corticosterone.	Corticosterone	140-154	adrenoceptor alpha 1B	Rattus norvegicus	14-36
10564730-4	1999	When animals are sacrificed at either 4 h following an aldosterone injection or at 24 h following a corticosterone injection, the synthesis of HSP27 in cerebellar slices is decreased.	Corticosterone	100-114	heat shock protein family B (small) member 1	Rattus norvegicus	143-148
10564730-5	1999	Treatment of adrenalectomized rats with either corticosterone, RU-28362 or aldosterone produces increased synthesis of HSP27.	Corticosterone	47-61	heat shock protein family B (small) member 1	Rattus norvegicus	119-124
10564730-8	1999	The upregulated synthesis of HSP27 in the cerebellum following an acute exposure to stress-like elevations in corticosterone titers may contribute to the relative resistance of this brain region to cellular insults.	Corticosterone	110-124	heat shock protein family B (small) member 1	Rattus norvegicus	29-34
10557342-0	1999	Long-term exposure to high corticosterone levels attenuates serotonin responses in rat hippocampal CA1 neurons.	Corticosterone	27-41	carbonic anhydrase 1	Rattus norvegicus	99-102
11498928-4	1999	Corticosterone (CORT), progesterone (P) and dexamethasone (DEX) had rapid effects on the glycine uptake.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
10557342-4	1999	Rats were injected daily for 3 weeks with a high dose of corticosterone; electrophysiological responses to serotonin were recorded intracellularly from CA1 pyramidal neurons in vitro.	Corticosterone	57-71	carbonic anhydrase 1	Rattus norvegicus	152-155
10539769-6	1999	In addition, significant diet-inducer interactions were observed in the expression of CYP3A apoprotein and activities toward ethylmorphine, corticosterone and testosterone (P &lt; 0.05).	Corticosterone	140-154	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	86-91
10567193-2	1999	Abnormal activity of 11beta-hydroxysteroid dehydrogenase enzymes (11beta-HSD1 and 11beta-HSD2), which interconvert corticosterone and inactive 11-dehydrocorticosterone, might contribute to the LH phenotype by regulating corticosteroid hormone access to receptors.	Corticosterone	115-129	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	66-77
10567193-2	1999	Abnormal activity of 11beta-hydroxysteroid dehydrogenase enzymes (11beta-HSD1 and 11beta-HSD2), which interconvert corticosterone and inactive 11-dehydrocorticosterone, might contribute to the LH phenotype by regulating corticosteroid hormone access to receptors.	Corticosterone	115-129	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	82-93
10537165-6	1999	As early as 6 h, Western blots demonstrated a dose-dependent decrease in the Bcl-2/Bax ratio, which reached a minimum of 0.18 in osteoblasts treated with 1000 nM corticosterone for 72 h. This reduction in Bcl-2/Bax was abolished by treating osteoblasts simultaneously with 17beta-estradiol, but not with 17alpha-estradiol.	Corticosterone	162-176	B cell leukemia/lymphoma 2	Mus musculus	77-82
10537165-6	1999	As early as 6 h, Western blots demonstrated a dose-dependent decrease in the Bcl-2/Bax ratio, which reached a minimum of 0.18 in osteoblasts treated with 1000 nM corticosterone for 72 h. This reduction in Bcl-2/Bax was abolished by treating osteoblasts simultaneously with 17beta-estradiol, but not with 17alpha-estradiol.	Corticosterone	162-176	BCL2-associated X protein	Mus musculus	83-86
10537165-6	1999	As early as 6 h, Western blots demonstrated a dose-dependent decrease in the Bcl-2/Bax ratio, which reached a minimum of 0.18 in osteoblasts treated with 1000 nM corticosterone for 72 h. This reduction in Bcl-2/Bax was abolished by treating osteoblasts simultaneously with 17beta-estradiol, but not with 17alpha-estradiol.	Corticosterone	162-176	B cell leukemia/lymphoma 2	Mus musculus	205-210
10537165-6	1999	As early as 6 h, Western blots demonstrated a dose-dependent decrease in the Bcl-2/Bax ratio, which reached a minimum of 0.18 in osteoblasts treated with 1000 nM corticosterone for 72 h. This reduction in Bcl-2/Bax was abolished by treating osteoblasts simultaneously with 17beta-estradiol, but not with 17alpha-estradiol.	Corticosterone	162-176	BCL2-associated X protein	Mus musculus	211-214
10516131-5	1999	Corticosterone levels comparable to stress-induced production completely reversed leptin-induced reductions in weight gain and body fat, despite significant attenuation by leptin of corticosterone-induced increases in plasma insulin levels.	Corticosterone	0-14	leptin	Mus musculus	82-88
10529444-4	1999	Exposure to the OF or ether fumes both produced increases in plasma corticosterone (CORT) levels; notably, peak levels of secretion were elevated in the ether group, suggestive of augmented HPA secretory activity to this stressor.	Corticosterone	68-82	cortistatin	Homo sapiens	84-88
11081156-3	1999	GM-CSF at 45 (P &lt; 0.01), 90 (P &lt; 0.01) and at 45 (P &lt; 0.001), 90 (P &lt; 0.001) and 180 min (P &lt; 0.001) increased the secretion of ACTH and corticosterone, respectively.	Corticosterone	152-166	colony stimulating factor 2	Rattus norvegicus	0-6
11081156-5	1999	of GM-CSF increased the ACTH (P &lt; 0.001) and corticosterone (P &lt; 0.001) concentration in blood plasma.	Corticosterone	48-62	colony stimulating factor 2	Rattus norvegicus	3-9
10516131-5	1999	Corticosterone levels comparable to stress-induced production completely reversed leptin-induced reductions in weight gain and body fat, despite significant attenuation by leptin of corticosterone-induced increases in plasma insulin levels.	Corticosterone	182-196	leptin	Mus musculus	172-178
10491169-3	1999	It could be clearly demonstrated that Adx mutants Adx 4-114 and Adx 4-108, possessing enhanced electron transfer abilities, produce increases in corticosterone and aldosterone biosynthesis.	Corticosterone	145-159	ferredoxin 1	Homo sapiens	38-41
10709765-2	1999	In comparison with their normal littermates, transgenic h-GH-RH mice had elevated plasma levels of GH, prolactin (PRL), and corticosterone.	Corticosterone	124-138	growth hormone	Mus musculus	58-60
10491169-3	1999	It could be clearly demonstrated that Adx mutants Adx 4-114 and Adx 4-108, possessing enhanced electron transfer abilities, produce increases in corticosterone and aldosterone biosynthesis.	Corticosterone	145-159	ferredoxin 1	Homo sapiens	50-53
10491169-3	1999	It could be clearly demonstrated that Adx mutants Adx 4-114 and Adx 4-108, possessing enhanced electron transfer abilities, produce increases in corticosterone and aldosterone biosynthesis.	Corticosterone	145-159	ferredoxin 1	Homo sapiens	50-53
10491169-4	1999	Based on the Vmax values of corticosterone and aldosterone formation, Adx 4-108 and Adx 4-114 enhance corticosterone synthesis 1.3-fold and aldosterone formation threefold and twofold, respectively.	Corticosterone	28-42	ferredoxin 1	Homo sapiens	70-73
10491169-4	1999	Based on the Vmax values of corticosterone and aldosterone formation, Adx 4-108 and Adx 4-114 enhance corticosterone synthesis 1.3-fold and aldosterone formation threefold and twofold, respectively.	Corticosterone	28-42	ferredoxin 1	Homo sapiens	84-87
10491169-4	1999	Based on the Vmax values of corticosterone and aldosterone formation, Adx 4-108 and Adx 4-114 enhance corticosterone synthesis 1.3-fold and aldosterone formation threefold and twofold, respectively.	Corticosterone	102-116	ferredoxin 1	Homo sapiens	70-73
10491169-4	1999	Based on the Vmax values of corticosterone and aldosterone formation, Adx 4-108 and Adx 4-114 enhance corticosterone synthesis 1.3-fold and aldosterone formation threefold and twofold, respectively.	Corticosterone	102-116	ferredoxin 1	Homo sapiens	84-87
10491169-7	1999	It could be shown that Adx 1-108 enhances the formation of aldosterone by bovine CYP11B1 and by human CYP11B2, and stimulates the production of corticosterone by bovine CYP11B1 and human CYP11B1 and CYP11B2 also.	Corticosterone	144-158	ferredoxin 1	Homo sapiens	23-26
10491169-7	1999	It could be shown that Adx 1-108 enhances the formation of aldosterone by bovine CYP11B1 and by human CYP11B2, and stimulates the production of corticosterone by bovine CYP11B1 and human CYP11B1 and CYP11B2 also.	Corticosterone	144-158	cytochrome P450 11B1, mitochondrial	Bos taurus	169-176
10491169-7	1999	It could be shown that Adx 1-108 enhances the formation of aldosterone by bovine CYP11B1 and by human CYP11B2, and stimulates the production of corticosterone by bovine CYP11B1 and human CYP11B1 and CYP11B2 also.	Corticosterone	144-158	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	169-176
10500198-10	1999	In mice, it induces serum amyloid A, potentiates the induction by IL-1 of corticosterone and IL-6, and causes body weight loss and B cell hyperplasia with serum IgG and IgM increase.	Corticosterone	74-88	interleukin 1 complex	Mus musculus	66-70
10709762-3	1999	Somatotroph differentiation in chickens occurs between embryonic day (e-) 14 and e-16, and treatment of e-12 pituitary cells with e-16 serum or corticosterone induces growth hormone (GH) cell differentiation within 2 d in culture.	Corticosterone	144-158	growth hormone	Gallus gallus	167-181
10709762-3	1999	Somatotroph differentiation in chickens occurs between embryonic day (e-) 14 and e-16, and treatment of e-12 pituitary cells with e-16 serum or corticosterone induces growth hormone (GH) cell differentiation within 2 d in culture.	Corticosterone	144-158	growth hormone	Gallus gallus	183-185
10709762-10	1999	GH secretors were increased by e-16 serum and corticosterone.	Corticosterone	46-60	growth hormone	Gallus gallus	0-2
10546990-0	1999	Evidence for down-regulation of GAP-43 mRNA in Wobbler mouse spinal motoneurons by corticosterone and a 21-aminosteroid.	Corticosterone	83-97	growth associated protein 43	Mus musculus	32-38
10462366-5	1999	Cortical collecting tubules (CCT) were isolated by microdissection and used for measurements of the activity of 11beta-HSD2 by assessing the conversion of corticosterone to dehydrocorticosterone.	Corticosterone	155-169	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	112-123
10447809-12	1999	Incubation of anterior pituitary cells with dexamethasone or corticosterone (0.1 and 1.0 microM) prior to fixation and analysis produced a significant, concentration-dependent decrease in intracellular ir-LC1 and a concomitant increase in the amount of ir-LC1 detected on the surface of the cells; the effects of the two steroids were indistinguishable quantitatively.	Corticosterone	61-75	annexin A1	Homo sapiens	205-208
10465257-9	1999	A significant increase in plasma corticosterone levels was also found in animals that received iv IL-6 injection after being pretreated 6 h before with the very low dose of LPS.	Corticosterone	33-47	interleukin 6	Rattus norvegicus	98-102
10523817-6	1999	In addition, alpha2C-KO was associated with attenuated elevation of plasma corticosterone after different stressors, and overexpression of alpha2C-ARs was linked with increased corticosterone levels after repeated stress.	Corticosterone	75-89	adrenergic receptor, alpha 2c	Mus musculus	13-20
10523817-6	1999	In addition, alpha2C-KO was associated with attenuated elevation of plasma corticosterone after different stressors, and overexpression of alpha2C-ARs was linked with increased corticosterone levels after repeated stress.	Corticosterone	177-191	adrenergic receptor, alpha 2c	Mus musculus	139-146
10467229-7	1999	In this study corticosterone and dexamethasone treatments increased the number of AT1 receptors by activating the glucocorticoid receptor (GR).	Corticosterone	14-28	angiotensin II receptor type 1	Homo sapiens	82-85
10467229-7	1999	In this study corticosterone and dexamethasone treatments increased the number of AT1 receptors by activating the glucocorticoid receptor (GR).	Corticosterone	14-28	nuclear receptor subfamily 3 group C member 1	Homo sapiens	114-137
10467229-7	1999	In this study corticosterone and dexamethasone treatments increased the number of AT1 receptors by activating the glucocorticoid receptor (GR).	Corticosterone	14-28	nuclear receptor subfamily 3 group C member 1	Homo sapiens	139-141
10447809-12	1999	Incubation of anterior pituitary cells with dexamethasone or corticosterone (0.1 and 1.0 microM) prior to fixation and analysis produced a significant, concentration-dependent decrease in intracellular ir-LC1 and a concomitant increase in the amount of ir-LC1 detected on the surface of the cells; the effects of the two steroids were indistinguishable quantitatively.	Corticosterone	61-75	annexin A1	Homo sapiens	256-259
10457537-1	1999	Multiple neurochemical estimates were used to examine peripheral corticosterone (CORT) effects in dopaminergic terminal regions.	Corticosterone	65-79	cortistatin	Homo sapiens	81-85
10474050-8	1999	injection of mTNF-alpha also increased cerebral tryptophan concentrations and MHPG/NE ratios at 2 h and caused a rapid and prolonged elevation of plasma corticosterone concentrations lasting for at least 2 h. We observed no significant changes in dopamine or its catabolites, or in 5-hydroxytryptamine or its major catabolite, 5-hydroxyindoleacetic acid, after either i.p.	Corticosterone	153-167	tumor necrosis factor	Mus musculus	13-23
10519057-1	1999	Corticosterone or cortisol, stress hormones in rat and human, respectively, alter neurotransmitter receptor-mediated responses in the brain.	Corticosterone	0-14	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	82-107
10622406-3	1999	Both orexin-A and orexin-B raised basal corticosterone secretion of dispersed rat zona fasciculata-reticularis (ZF/R) cells, their maximal effective concentration being 10(-8) M. In contrast, orexins did not affect either maximally ACTH (10(-9) M)-stimulated corticosterone production by ZF/R cells or the basal and agonist-stimulated aldosterone secretion of dispersed zona glomerulosa cells.	Corticosterone	40-54	hypocretin neuropeptide precursor	Rattus norvegicus	5-13
10622406-3	1999	Both orexin-A and orexin-B raised basal corticosterone secretion of dispersed rat zona fasciculata-reticularis (ZF/R) cells, their maximal effective concentration being 10(-8) M. In contrast, orexins did not affect either maximally ACTH (10(-9) M)-stimulated corticosterone production by ZF/R cells or the basal and agonist-stimulated aldosterone secretion of dispersed zona glomerulosa cells.	Corticosterone	259-273	hypocretin neuropeptide precursor	Rattus norvegicus	5-13
10622406-5	1999	Orexins (10(-8) M) enhanced cyclic-AMP release by ZF/R cells, and the selective inhibitor of protein-kinase A (PKA) H-89 (10(-5) M) abolished corticosterone responses to both ACTH (10(-9) M) and orexins (10(-8) M).	Corticosterone	142-156	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	93-109
10622406-5	1999	Orexins (10(-8) M) enhanced cyclic-AMP release by ZF/R cells, and the selective inhibitor of protein-kinase A (PKA) H-89 (10(-5) M) abolished corticosterone responses to both ACTH (10(-9) M) and orexins (10(-8) M).	Corticosterone	142-156	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	111-114
10622406-6	1999	A subcutaneous injection of both orexins (5 or 10 nmol/kg) evoked a clear-cut increase in the plasma concentration of corticosterone (but not aldosterone), the effect of orexin-A being significantly more intense than that of orexin-B.	Corticosterone	118-132	hypocretin neuropeptide precursor	Rattus norvegicus	170-178
10497908-5	1999	Decynium22 and corticosterone, known inhibitors of rat Organic Cation Transporter 1 (rOCT1), markedly reduced [3H]MPP+ efflux.	Corticosterone	15-29	solute carrier family 22 member 1	Rattus norvegicus	55-83
10497908-5	1999	Decynium22 and corticosterone, known inhibitors of rat Organic Cation Transporter 1 (rOCT1), markedly reduced [3H]MPP+ efflux.	Corticosterone	15-29	solute carrier family 22 member 1	Rattus norvegicus	85-90
10519057-5	1999	Corticosterone treatment selectively altered the levels of GIRK1 and GIRK2 (measured on immunoblots) depending on the subfield of the hippocampus examined.	Corticosterone	0-14	potassium inwardly-rectifying channel, subfamily J, member 3	Rattus norvegicus	59-64
10519057-5	1999	Corticosterone treatment selectively altered the levels of GIRK1 and GIRK2 (measured on immunoblots) depending on the subfield of the hippocampus examined.	Corticosterone	0-14	potassium inwardly-rectifying channel, subfamily J, member 6	Rattus norvegicus	69-74
10519057-6	1999	These data lend credence to the hypothesis that corticosterone differentially alters neurotransmitter receptor-mediated responses dependent on the brain area.	Corticosterone	48-62	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	85-110
10455320-9	1999	Similarly to dexamethasone (TNF-alpha- and LPS-induced apoptosis are prevented with IC50 values of 0.8 and 0.9 nM, respectively), other synthetic and natural forms of glucocorticoids, such as fluocinolone, prednisolone, hydrocortisone, and corticosterone potently inhibited cell death with IC50 values of 0.2, 6, 50 and 1000 nM, for TNF-alpha and 0.7, 8, 100 and 500 nM for LPS, respectively.	Corticosterone	240-254	tumor necrosis factor	Bos taurus	28-37
10509797-2	1999	GR-/- mice show impaired negative feedback in the hypothalamic-pituitary-adrenal axis, resulting in elevated circulating levels of ACTH and corticosterone.	Corticosterone	140-154	nuclear receptor subfamily 3, group C, member 1	Mus musculus	0-2
10497964-0	1999	Corticosterone regulation of 5-HT2A receptor-mediated behaviors: attenuation by melatonin.	Corticosterone	0-14	5-hydroxytryptamine receptor 2A	Rattus norvegicus	29-35
10446326-11	1999	E(2) replacement significantly increased serum corticosterone (CORT) levels.	Corticosterone	47-61	cortistatin	Rattus norvegicus	63-67
10433210-3	1999	Restricting consumption of normal or protein-free diet for 9 days to the lower intake in protein-deprived CRH KO mice increased evening plasma corticosterone in WT but not KO mice.	Corticosterone	143-157	corticotropin releasing hormone	Mus musculus	106-109
10433210-8	1999	Corticosterone, but not the progestational appetite stimulant megestrol acetate, prevented hypophagia in CRH KO mice given protein-free diet.	Corticosterone	0-14	corticotropin releasing hormone	Mus musculus	105-108
10596723-2	1999	In vivo, mice transgenic for human growth hormone (hGH) show significantly elevated levels of corticosterone, enlarged adrenal glands, and altered levels of insulin-like growth factor binding proteins (IGF-BPs).	Corticosterone	94-108	growth hormone 1	Homo sapiens	35-49
10447795-2	1999	Immediately after deprivation corticosterone (CORT) is elevated.	Corticosterone	30-44	cortistatin	Rattus norvegicus	46-50
10414997-0	1999	Independent and overlapping effects of corticosterone and testosterone on corticotropin-releasing hormone and arginine vasopressin mRNA expression in the paraventricular nucleus of the hypothalamus and stress-induced adrenocorticotropic hormone release.	Corticosterone	39-53	arginine vasopressin	Rattus norvegicus	119-130
10396022-6	1999	In liver, in the basal state, the tyrosine phosphorylation of IR, IRS-1 and Shc, and the IR-associated PI 3"-kinase activity were largely decreased by corticosterone.	Corticosterone	151-165	SHC adaptor protein 1	Gallus gallus	76-79
11498973-4	1999	It was also found that the NE and corticosterone levels in the serum of rats were significantly reduced after icv of AVP.	Corticosterone	34-48	arginine vasopressin	Rattus norvegicus	117-120
10398300-0	1999	Brain-derived neurotrophic factor prevents neuronal cell death induced by corticosterone.	Corticosterone	74-88	brain-derived neurotrophic factor	Rattus norvegicus	0-33
10398300-1	1999	Corticosterone (CORT), one of the glucocorticoids, causes neuronal damage in the hippocampus, but the mechanism(s) of action underlying its effects remains unknown.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
10396022-3	1999	Corticosterone significantly decreased specific insulin binding in liver and the amount of insulin receptor substrate-1 (IRS-1) and p85 (regulatory subunit of phosphatidylinositol (PI) 3"-kinase) in both tissues.	Corticosterone	0-14	insulin receptor substrate 1	Gallus gallus	91-119
10396022-3	1999	Corticosterone significantly decreased specific insulin binding in liver and the amount of insulin receptor substrate-1 (IRS-1) and p85 (regulatory subunit of phosphatidylinositol (PI) 3"-kinase) in both tissues.	Corticosterone	0-14	insulin receptor substrate 1	Gallus gallus	121-126
10396022-10	1999	On this background, corticosterone decreased the basal PI 3"-kinase activity and prevented the phosphorylation of Shc in response to refeeding.	Corticosterone	20-34	SHC adaptor protein 1	Gallus gallus	114-117
10396022-6	1999	In liver, in the basal state, the tyrosine phosphorylation of IR, IRS-1 and Shc, and the IR-associated PI 3"-kinase activity were largely decreased by corticosterone.	Corticosterone	151-165	insulin receptor	Gallus gallus	62-64
10377371-1	1999	Consistent with the proposition that cytokines act as immunotransmitters between the immune system and the brain, systemic administration of the proinflammatory cytokine tumor necrosis factor-alpha (TNF-alpha; 1.0-4.0 microg) induced mild illness in CD-1 mice, increased plasma corticosterone concentrations, and altered central norepinephrine, dopamine, and serotonin turnover.	Corticosterone	278-292	tumor necrosis factor	Mus musculus	170-197
10396022-6	1999	In liver, in the basal state, the tyrosine phosphorylation of IR, IRS-1 and Shc, and the IR-associated PI 3"-kinase activity were largely decreased by corticosterone.	Corticosterone	151-165	insulin receptor substrate 1	Gallus gallus	66-71
10404037-8	1999	Conversely, rats treated with 100 mg of CORT had lower serum levels of IGF-1 and higher serum levels of testosterone, progesterone, and insulin than their controls.	Corticosterone	40-44	insulin-like growth factor 1	Rattus norvegicus	71-76
10720424-0	1999	Direct effects of prolactin on corticosterone release by zona fasciculata-reticularis cells from male rats.	Corticosterone	31-45	prolactin	Rattus norvegicus	18-27
10720424-2	1999	The aim of this study was to investigate the function and mechanism of PRL on the production of corticosterone by zona fasciculata-reticularis (ZFR) cells in vitro.	Corticosterone	96-110	prolactin	Rattus norvegicus	71-74
10720424-4	1999	PRL stimulated the corticosterone release in a dose-dependent pattern in the ZFR cells from normal male rats.	Corticosterone	19-33	prolactin	Rattus norvegicus	0-3
10720424-6	1999	PRL enhanced the stimulatory effects of cAMP mimetic reagents, i.e., forskolin, 8-bromo-adenosine 3",5"-cyclic monophosphate (8-Br-cAMP), and IBMX on the release of corticosterone.	Corticosterone	165-179	prolactin	Rattus norvegicus	0-3
10720424-13	1999	These results suggest that PRL increase the release of corticosterone by ZFR cells via cAMP cascades and 3beta-HSD activity.	Corticosterone	55-69	prolactin	Rattus norvegicus	27-30
10352121-7	1999	Cells exposed to corticosterone (100 nM) or CBX (1 microM) alone for 24 hr and then stimulated with angiotensin II (10 nM) had responses similar to controls.	Corticosterone	17-31	angiotensinogen	Rattus norvegicus	100-114
10411633-2	1999	The effect of CYP11A1 on CYP11B isozymes was examined by studying the conversion of 11-deoxycorticosterone to corticosterone, 18-hydroxycorticosterone and aldosterone.	Corticosterone	92-106	cytochrome P450 family 11 subfamily A member 1	Homo sapiens	14-21
10411633-2	1999	The effect of CYP11A1 on CYP11B isozymes was examined by studying the conversion of 11-deoxycorticosterone to corticosterone, 18-hydroxycorticosterone and aldosterone.	Corticosterone	92-106	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	25-31
10320721-1	1999	This study was designed to investigate the contribution of the hypothalamus, anterior pituitary and adrenal gland in the increase of adrenocorticotropin (ACTH) and corticosterone secretion induced by gastrin-releasing peptide (GRP) on in vitro isolated hypothalamus, pituitary and adrenal gland.	Corticosterone	164-178	gastrin releasing peptide	Homo sapiens	200-225
10320721-1	1999	This study was designed to investigate the contribution of the hypothalamus, anterior pituitary and adrenal gland in the increase of adrenocorticotropin (ACTH) and corticosterone secretion induced by gastrin-releasing peptide (GRP) on in vitro isolated hypothalamus, pituitary and adrenal gland.	Corticosterone	164-178	gastrin releasing peptide	Homo sapiens	227-230
10320721-3	1999	Moderate concentrations of GRP (1 and 10 nM) were able to increase the release of corticotropin-releasing factor (CRF)-like material in the medium of isolated hypothalami, whereas higher concentrations (100 and 1000 nM) were needed to elevate ACTH and corticosterone secretion in pituitary and adrenal quarters, respectively.	Corticosterone	252-266	gastrin releasing peptide	Homo sapiens	27-30
10320721-5	1999	However, this antagonist (100 nM) completely blocked the stimulatory effects of GRP (100 nM) on bioactive CRF, ACTH and corticosterone release.	Corticosterone	120-134	gastrin releasing peptide	Homo sapiens	80-83
10320721-7	1999	These results suggest that: (1) the hypothalamus, anterior pituitary and adrenal gland seem to contribute to the elevation of ACTH and corticosterone secretion induced by GRP by a mechanism mediated through GRP receptors and (2) the stimulation of ACTH by GRP in the anterior pituitary appears to be dependent upon the presence of physiological concentrations of extracellular Ca2+.	Corticosterone	135-149	gastrin releasing peptide	Homo sapiens	171-174
10233999-2	1999	Acute or chronic administration of corticosterone to adult rats decreased RGS4 mRNA levels in the PVN but increased these levels in the LC.	Corticosterone	35-49	regulator of G-protein signaling 4	Rattus norvegicus	74-78
10233999-5	1999	The molecular mechanisms of RGS4 mRNA regulation were further investigated in vitro in the LC-like CATH.a cell line and the neuroendocrine AtT20 cell line using the synthetic corticosterone analog dexamethasone.	Corticosterone	175-189	regulator of G-protein signaling 4	Mus musculus	28-32
10370862-12	1999	injection of corticosterone-elevated hypothalamic TRH contents and decreased plasma TSH concentrations, a corticosterone-induced TSH decrease during fasting is suggested through an action at the level of the hypothalamus.	Corticosterone	13-27	thyrotropin releasing hormone	Gallus gallus	50-53
10414997-0	1999	Independent and overlapping effects of corticosterone and testosterone on corticotropin-releasing hormone and arginine vasopressin mRNA expression in the paraventricular nucleus of the hypothalamus and stress-induced adrenocorticotropic hormone release.	Corticosterone	39-53	corticotropin releasing hormone	Rattus norvegicus	74-105
10370862-12	1999	injection of corticosterone-elevated hypothalamic TRH contents and decreased plasma TSH concentrations, a corticosterone-induced TSH decrease during fasting is suggested through an action at the level of the hypothalamus.	Corticosterone	106-120	thyrotropin releasing hormone	Gallus gallus	50-53
10337864-5	1999	After incubation of the transfected cells with HDL, corticosterone secretion from CLA-1-transfected cells increased to about two times the level in mock-transfected cells.	Corticosterone	52-66	scavenger receptor class B member 1	Homo sapiens	82-87
11798659-14	1999	There is evidence that it inhibits the enzymes of both 11beta-HSD2 and CYP11B2 in vasculature and leads to higher corticosterone and lower aldosterone production in vessels as well as an increase in vascular responses to norepinephrine.	Corticosterone	114-128	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	55-66
10232677-6	1999	Consistent with the expression of 11beta-hydroxysteroid dehydrogenase type 2, which metabolizes glucocorticoids to inactive 11-dehydroderivates, carbenoxolone potentiated the corticosterone-stimulated Isc.	Corticosterone	175-189	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	34-76
10320732-0	1999	Opposite effects on NCAM expression in the rat frontal cortex induced by acute vs. chronic corticosterone treatments.	Corticosterone	91-105	neural cell adhesion molecule 1	Rattus norvegicus	20-24
10320732-2	1999	In this work, the effects of different regimes of subcutaneous corticosterone administration (acute-single injection-vs. chronic-daily injection for 21 days) on the expression of the neural cell adhesion molecule (NCAM) were evaluated in different rat brain regions (CA1-CA4, dentate gyrus, frontal cortex, striatum, and hypothalamus).	Corticosterone	63-77	neural cell adhesion molecule 1	Rattus norvegicus	183-212
10320732-2	1999	In this work, the effects of different regimes of subcutaneous corticosterone administration (acute-single injection-vs. chronic-daily injection for 21 days) on the expression of the neural cell adhesion molecule (NCAM) were evaluated in different rat brain regions (CA1-CA4, dentate gyrus, frontal cortex, striatum, and hypothalamus).	Corticosterone	63-77	neural cell adhesion molecule 1	Rattus norvegicus	214-218
10320732-6	1999	The results showed a biphasic modulation of NCAM levels at the frontal cortex, with acute corticosterone resulting in enhanced NCAM levels at 8 h and 24 h posttraining, and the chronic treatment decreasing its expression.	Corticosterone	90-104	neural cell adhesion molecule 1	Rattus norvegicus	44-48
10320732-6	1999	The results showed a biphasic modulation of NCAM levels at the frontal cortex, with acute corticosterone resulting in enhanced NCAM levels at 8 h and 24 h posttraining, and the chronic treatment decreasing its expression.	Corticosterone	90-104	neural cell adhesion molecule 1	Rattus norvegicus	127-131
10320732-7	1999	None of the other brain areas examined showed significant changes in NCAM expression with corticosterone treatments, except for the hypothalamus that showed reduced NCAM levels after the chronic corticosterone regime.	Corticosterone	90-104	neural cell adhesion molecule 1	Rattus norvegicus	69-73
10320732-7	1999	None of the other brain areas examined showed significant changes in NCAM expression with corticosterone treatments, except for the hypothalamus that showed reduced NCAM levels after the chronic corticosterone regime.	Corticosterone	195-209	neural cell adhesion molecule 1	Rattus norvegicus	165-169
10320732-8	1999	These results support the view that NCAM regulation at the frontal cortex might be a mechanism by which corticosterone treatments influence memory formation.	Corticosterone	104-118	neural cell adhesion molecule 1	Rattus norvegicus	36-40
11798659-14	1999	There is evidence that it inhibits the enzymes of both 11beta-HSD2 and CYP11B2 in vasculature and leads to higher corticosterone and lower aldosterone production in vessels as well as an increase in vascular responses to norepinephrine.	Corticosterone	114-128	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	71-78
10357248-1	1999	Both repeated stress and corticosterone administration induce remodeling of apical dendrites of hippocampal CA3 pyramidal neurons.	Corticosterone	25-39	carbonic anhydrase 3	Rattus norvegicus	108-111
10327201-1	1999	Daily injections with high doses of corticosterone for 3 weeks were previously found to result in atrophy of the dendritic tree of hippocampal CA3 neurons, which form a major input source to CA1 pyramidal cells.	Corticosterone	36-50	carbonic anhydrase 3	Rattus norvegicus	143-146
10327201-1	1999	Daily injections with high doses of corticosterone for 3 weeks were previously found to result in atrophy of the dendritic tree of hippocampal CA3 neurons, which form a major input source to CA1 pyramidal cells.	Corticosterone	36-50	carbonic anhydrase 1	Rattus norvegicus	191-194
10327201-2	1999	In this study we examined if exposure of rats to a similar chronic corticosterone treatment is associated with changes in field responses of CA1 neurons to stimulation of Schaffer collateral/commissural fibers.	Corticosterone	67-81	carbonic anhydrase 1	Rattus norvegicus	141-144
10327201-5	1999	The data suggest that exposure of rats for 3 weeks to very high corticosterone levels induces adaptational changes in the CA1 hippocampal network function which partly normalize the effects seen with less prolonged corticosterone treatment.	Corticosterone	64-78	carbonic anhydrase 1	Rattus norvegicus	122-125
10327201-5	1999	The data suggest that exposure of rats for 3 weeks to very high corticosterone levels induces adaptational changes in the CA1 hippocampal network function which partly normalize the effects seen with less prolonged corticosterone treatment.	Corticosterone	215-229	carbonic anhydrase 1	Rattus norvegicus	122-125
10320009-0	1999	Oxytocin causes a sustained decrease in plasma levels of corticosterone in rats.	Corticosterone	57-71	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	0-8
10320009-1	1999	The aim of this study was to investigate how oxytocin (OXT) influences plasma levels of ACTH and corticosterone in rats.	Corticosterone	97-111	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	45-53
10320009-1	1999	The aim of this study was to investigate how oxytocin (OXT) influences plasma levels of ACTH and corticosterone in rats.	Corticosterone	97-111	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	55-58
10320009-2	1999	A single injection of OXT (1 mg/kg s.c.) caused a transient increase in ACTH and corticosterone.	Corticosterone	81-95	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	22-25
10320009-3	1999	In contrast, 1 mg/kg OXT (but not 10-100 microg/kg) decreased corticosterone, but not ACTH levels, 6 h after the injection.	Corticosterone	62-76	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	21-24
10320009-5	1999	An acute challenge with ACTH increased corticosterone to the same level in rats pretreated with OXT and controls.	Corticosterone	39-53	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	96-99
10230506-3	1999	Hypothermia and increased serum corticosterone level were observed in LB50016-treated rats, which are mediated mostly by post synaptic 5-HT1A receptor activation.	Corticosterone	32-46	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	135-150
10098485-2	1999	Plasma corticosterone levels of PEPCK-IGF-II transgenic mice were 2-fold higher than in age- and sex-matched controls, both in the morning (7.4 +/- 1.5 vs. 17.8 +/- 3.9 ng/ml, P &lt; 0.01) and in the evening (33.3 +/- 6.5 vs. 65.3 +/- 12 ng/ml, P &lt; 0.01).	Corticosterone	7-21	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	32-37
10098485-2	1999	Plasma corticosterone levels of PEPCK-IGF-II transgenic mice were 2-fold higher than in age- and sex-matched controls, both in the morning (7.4 +/- 1.5 vs. 17.8 +/- 3.9 ng/ml, P &lt; 0.01) and in the evening (33.3 +/- 6.5 vs. 65.3 +/- 12 ng/ml, P &lt; 0.01).	Corticosterone	7-21	insulin-like growth factor 2	Mus musculus	38-44
10098485-3	1999	When PEPCK-IGF-II transgenic mice were subjected to an ACTH challenge, corticosterone levels were stimulated 6-fold, to 396 +/- 17 ng/ml after 60 min, compared with 230 +/- 24 ng/ml in the control group.	Corticosterone	71-85	phosphoenolpyruvate carboxykinase 2, mitochondrial	Homo sapiens	5-10
10098485-3	1999	When PEPCK-IGF-II transgenic mice were subjected to an ACTH challenge, corticosterone levels were stimulated 6-fold, to 396 +/- 17 ng/ml after 60 min, compared with 230 +/- 24 ng/ml in the control group.	Corticosterone	71-85	insulin-like growth factor 2	Mus musculus	11-17
10098485-10	1999	In conclusion, our data indicate that postnatal overexpression of IGF-II induces an increased adrenal weight and elevated corticosterone serum levels, presumably by a direct mitogenic effect of IGF-II on adrenocortical fasciculata cells.	Corticosterone	122-136	insulin-like growth factor 2	Mus musculus	66-72
10098485-10	1999	In conclusion, our data indicate that postnatal overexpression of IGF-II induces an increased adrenal weight and elevated corticosterone serum levels, presumably by a direct mitogenic effect of IGF-II on adrenocortical fasciculata cells.	Corticosterone	122-136	insulin-like growth factor 2	Mus musculus	194-200
10223280-6	1999	gain, plasma transcortin and thymus weight were reduced to a greater extent by chronic corticosterone in BN rats than in F344 rats, possibly as a consequence of higher free, active fraction of plasma corticosterone due to lower plasma transcortin concentrations and/or a greater efficiency of GR-related mechanisms in BN rats.	Corticosterone	87-101	serpin family A member 6	Rattus norvegicus	13-24
10103142-2	1999	In a companion study, we demonstrated that suppression of corticosterone by adrenalectomy increased neurogenesis and PSA-NCAM expression in the dentate gyrus of adult rats.	Corticosterone	58-72	neural cell adhesion molecule 1	Rattus norvegicus	121-125
10223286-8	1999	A significant effect of alpha-MSH AS on the corticosterone response to i.c.v.	Corticosterone	44-58	proopiomelanocortin	Rattus norvegicus	24-33
10223280-6	1999	gain, plasma transcortin and thymus weight were reduced to a greater extent by chronic corticosterone in BN rats than in F344 rats, possibly as a consequence of higher free, active fraction of plasma corticosterone due to lower plasma transcortin concentrations and/or a greater efficiency of GR-related mechanisms in BN rats.	Corticosterone	87-101	serpin family A member 6	Rattus norvegicus	235-246
10223286-10	1999	The mean area under the corticosterone response curve for the first 3 h in the alpha-MSH AS treated animals was 144% of that in the NRS treated animals (P &lt;0.05).	Corticosterone	24-38	proopiomelanocortin	Rattus norvegicus	79-88
10223280-6	1999	gain, plasma transcortin and thymus weight were reduced to a greater extent by chronic corticosterone in BN rats than in F344 rats, possibly as a consequence of higher free, active fraction of plasma corticosterone due to lower plasma transcortin concentrations and/or a greater efficiency of GR-related mechanisms in BN rats.	Corticosterone	87-101	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	293-295
10223286-12	1999	Corticosterone levels rose to a peak of 42+/-3.9 microg/dl in the alpha-MSH AS treated rats vs 37+/-4.6 microg/dl in the NRS treated rats; this difference was not significant.	Corticosterone	0-14	proopiomelanocortin	Rattus norvegicus	66-75
10064590-2	1999	Aged beta2(-/-) mutant mice showed region-specific alterations in cortical regions, including neocortical hypotrophy, loss of hippocampal pyramidal neurons, astro- and microgliosis and elevation of serum corticosterone levels.	Corticosterone	204-218	G protein-coupled receptor 162	Mus musculus	5-10
10206451-8	1999	Administration of ovine PRL in vitro resulted in a dose-dependent increase of corticosterone production.	Corticosterone	78-92	prolactin	Rattus norvegicus	24-27
10206451-9	1999	In oil-treated middle-aged rats, ovine PRL-stimulated corticosterone release was higher than in young rats.	Corticosterone	54-68	prolactin	Rattus norvegicus	39-42
10206451-12	1999	These results suggest that the age-related increase of corticosterone production in female rats is associated with the stimulatory effect of PRL on ZFR cells and is due in part to an increase of cAMP generation.	Corticosterone	55-69	prolactin	Rattus norvegicus	141-144
10209070-5	1999	IL-1beta (0.02 microg/pup, administered twice daily from postnatal day 1 to 4) induced marked elevation in plasma corticosterone (CORT) level as compared to controls and LPS groups (0.4 microg or 1.2 microg LPS/pup, injected once daily from postnatal day 1 to 4).	Corticosterone	114-128	interleukin 1 beta	Rattus norvegicus	0-8
10209070-5	1999	IL-1beta (0.02 microg/pup, administered twice daily from postnatal day 1 to 4) induced marked elevation in plasma corticosterone (CORT) level as compared to controls and LPS groups (0.4 microg or 1.2 microg LPS/pup, injected once daily from postnatal day 1 to 4).	Corticosterone	130-134	interleukin 1 beta	Rattus norvegicus	0-8
10419017-2	1999	The type I isoform (11beta-HSD1) is a bidirectional enzyme but acts predominantly as a oxidoreductase to form the active glucocorticoids cortisol or corticosterone, while the type II enzyme (11beta-HSD2) acts unidirectionally producing inactive 11-keto metabolites.	Corticosterone	149-163	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	20-31
10344529-12	1999	Corticosterone had an IC50 of 72 microM, being about 700-fold less potent in inhibiting rOCT1 than uptake2.	Corticosterone	0-14	solute carrier family 22 member 1	Rattus norvegicus	88-93
10344529-15	1999	On the other hand, corticosterone and normetanephrine are significantly more potent in inhibiting uptake2 than rOCT1.	Corticosterone	19-33	solute carrier family 22 member 1	Rattus norvegicus	111-116
10399886-11	1999	These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine.	Corticosterone	222-236	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	142-153
10399886-11	1999	These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine.	Corticosterone	222-236	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	158-165
10067832-0	1999	Regulation of somatotroph differentiation and growth hormone (GH) secretion by corticosterone and GH-releasing hormone during embryonic development.	Corticosterone	79-93	growth hormone	Gallus gallus	46-60
10203238-2	1999	The most frequent and characteristic change is an abnormally high level of corticosterone in the blood, possibly due to changes in the activity of the hypothalamic neurons which synthesize corticotrophin-releasing hormone (CRH).	Corticosterone	75-89	corticotropin releasing hormone	Rattus norvegicus	189-221
10203238-2	1999	The most frequent and characteristic change is an abnormally high level of corticosterone in the blood, possibly due to changes in the activity of the hypothalamic neurons which synthesize corticotrophin-releasing hormone (CRH).	Corticosterone	75-89	corticotropin releasing hormone	Rattus norvegicus	223-226
10103082-0	1999	Episodic corticosterone treatment accelerates kindling epileptogenesis and triggers long-term changes in hippocampal CA1 cells, in the fully kindled state.	Corticosterone	9-23	carbonic anhydrase 1	Rattus norvegicus	117-120
10103082-1	1999	We tested the effect of episodic (approximately 10 days) corticosterone treatment on: (i) behavioural symptoms during kindling epileptogenesis; and (ii) electrical activity in the CA1 hippocampal area during epileptogenesis, and later on, in the fully kindled state.	Corticosterone	57-71	carbonic anhydrase 1	Rattus norvegicus	180-183
10103082-5	1999	However, other properties of CA1 cells studied in vitro, in the fully kindled state, were altered by the earlier episodic corticosterone treatment.	Corticosterone	122-136	carbonic anhydrase 1	Rattus norvegicus	29-32
10103082-6	1999	Thus, in kindled rats, the amplitude of the population spike in the CA1 area was significantly enhanced after prior exposure to high corticosterone levels.	Corticosterone	133-147	carbonic anhydrase 1	Rattus norvegicus	68-71
10067832-10	1999	Corticosterone in combination with GHRH was more effective than either hormone alone for increasing percentages of e-12 GH-secreting cells (from 9.6 +/- 0.8% with corticosterone to 15.9 +/- 1.5% with corticosterone plus GHRH), but this synergistic effect was not apparent until after 3 days of culture.	Corticosterone	163-177	growth hormone	Gallus gallus	35-37
10067832-10	1999	Corticosterone in combination with GHRH was more effective than either hormone alone for increasing percentages of e-12 GH-secreting cells (from 9.6 +/- 0.8% with corticosterone to 15.9 +/- 1.5% with corticosterone plus GHRH), but this synergistic effect was not apparent until after 3 days of culture.	Corticosterone	200-214	growth hormone releasing hormone	Gallus gallus	35-39
10067832-0	1999	Regulation of somatotroph differentiation and growth hormone (GH) secretion by corticosterone and GH-releasing hormone during embryonic development.	Corticosterone	79-93	growth hormone	Gallus gallus	62-64
10067832-10	1999	Corticosterone in combination with GHRH was more effective than either hormone alone for increasing percentages of e-12 GH-secreting cells (from 9.6 +/- 0.8% with corticosterone to 15.9 +/- 1.5% with corticosterone plus GHRH), but this synergistic effect was not apparent until after 3 days of culture.	Corticosterone	200-214	growth hormone	Gallus gallus	35-37
10067832-11	1999	Exposure to corticosterone in culture for 2, 3, and 6 days increased subsequent GH release from e-12 and e-14 pituitary cells during reverse hemolytic plaque assay.	Corticosterone	12-26	growth hormone	Gallus gallus	80-82
10067832-2	1999	Previously, we reported that somatotrophs become a significant population by embryonic day (e-) 16 of the chick and that corticosterone is the active compound responsible for the observed GH cell-differentiating activity of e-16 serum.	Corticosterone	121-135	growth hormone	Gallus gallus	188-190
10067832-9	1999	Conversely, corticosterone increased percentages of e-12 and e-14 GH-secreting cells (by as much as 14- and 3-fold above basal levels, respectively), but did not alter the proportions of e-17 GH cells.	Corticosterone	12-26	growth hormone	Gallus gallus	66-68
10067832-10	1999	Corticosterone in combination with GHRH was more effective than either hormone alone for increasing percentages of e-12 GH-secreting cells (from 9.6 +/- 0.8% with corticosterone to 15.9 +/- 1.5% with corticosterone plus GHRH), but this synergistic effect was not apparent until after 3 days of culture.	Corticosterone	0-14	growth hormone releasing hormone	Gallus gallus	220-224
10067832-10	1999	Corticosterone in combination with GHRH was more effective than either hormone alone for increasing percentages of e-12 GH-secreting cells (from 9.6 +/- 0.8% with corticosterone to 15.9 +/- 1.5% with corticosterone plus GHRH), but this synergistic effect was not apparent until after 3 days of culture.	Corticosterone	163-177	growth hormone releasing hormone	Gallus gallus	35-39
10077325-7	1999	Immunohistochemical studies on the nuclear translocation of a range of stress-activated protein kinases showed that stress-activated protein kinases 1, 2, 3 and 4 were all translocated by 10 min exposure to corticosterone (100 nM).	Corticosterone	207-221	mitogen-activated protein kinase 12	Rattus norvegicus	116-162
10416840-1	1999	11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the interconversion of active corticosterone and inert 11-dehydrocorticosterone.	Corticosterone	98-112	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	0-56
9950870-1	1999	Previous investigators have demonstrated that the tumor necrosis factor-alpha (TNF-alpha) response to endotoxin is inhibited by exogenous corticosterone or catecholamines both in vitro and in vivo, whereas others have reported that surgical and nonsurgical stress increase the endogenous concentrations of these stress-induced hormones.	Corticosterone	138-152	tumor necrosis factor	Rattus norvegicus	50-77
9931027-2	1999	In rodents such as rat, which utilize corticosterone as the major glucocorticoid, P450c17 is expressed predominantly in the gonads, and is absent in the adrenal.	Corticosterone	38-52	cytochrome P450, family 17, subfamily a, polypeptide 1	Rattus norvegicus	82-89
9931293-2	1999	The data show that Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism and recognizes 5alpha-androstan-3alpha,17beta-diol and androsterone as substrates (3alpha-hydroxysteroid dehydrogenase activity), but not testosterone, dihydrotestosterone, oestradiol and corticosterone (lack of 17beta-hydroxysteroid and 11beta-hydroxysteroid dehydrogenase activities).	Corticosterone	296-310	retinol dehydrogenase 5	Homo sapiens	19-23
9931293-2	1999	The data show that Rdh5 catalyses 9-cis-retinol metabolism equally efficiently as 11-cis-retinol metabolism and recognizes 5alpha-androstan-3alpha,17beta-diol and androsterone as substrates (3alpha-hydroxysteroid dehydrogenase activity), but not testosterone, dihydrotestosterone, oestradiol and corticosterone (lack of 17beta-hydroxysteroid and 11beta-hydroxysteroid dehydrogenase activities).	Corticosterone	296-310	dehydrogenase/reductase 9	Homo sapiens	191-226
9927337-7	1999	Turpentine-induced local inflammation produced pronounced elevations in the plasma concentrations of both ACTH and corticosterone in both CRF-R1 -/- and wild-type mice, but ACTH secretion could be inhibited by anti-CRF and anti-AVP sera only in wild-type mice.	Corticosterone	115-129	corticotropin releasing hormone receptor 1	Mus musculus	138-144
9950870-1	1999	Previous investigators have demonstrated that the tumor necrosis factor-alpha (TNF-alpha) response to endotoxin is inhibited by exogenous corticosterone or catecholamines both in vitro and in vivo, whereas others have reported that surgical and nonsurgical stress increase the endogenous concentrations of these stress-induced hormones.	Corticosterone	138-152	tumor necrosis factor	Rattus norvegicus	79-88
9986920-0	1999	Acute intrahippocampal injection of human interleukin-1beta stimulates the anterior pituitary POMC transcription and increases plasma levels of ACTH and corticosterone in the male rat.	Corticosterone	153-167	interleukin 1 beta	Homo sapiens	42-59
10207507-6	1999	There was a weak correlation between IGF-I and serum corticosterone (P &lt; 0.05), and between TGF-beta 1 mRNA levels and serum corticosterone concentration (P &lt; 0.05).	Corticosterone	128-142	transforming growth factor, beta 1	Rattus norvegicus	95-105
10102785-2	1999	It has previously been found that chronic administration of corticosterone leads to adrenal suppression and an attenuation of somatodendritic 5-HT1A receptor function.	Corticosterone	60-74	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	142-157
10102785-7	1999	Although repeated administration of corticosterone attenuates somatodendritic 5-HT1A receptor function, these data demonstrate that lowering of corticosteroid levels by ADX have no effect.	Corticosterone	36-50	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	78-93
9986926-4	1999	While basal and ether-stimulated levels of plasma corticosterone (CORT) were similar in the two groups, old animals presented a delayed termination of the response to ether stress.	Corticosterone	50-64	cortistatin	Rattus norvegicus	66-70
9986920-5	1999	Following this, animals were sacrificed at times 20, 45 and 90 min postinjection and a kinetic analysis of hIL-1beta action on plasma ACTH and corticosterone (CORT) concentrations and nuclear processing of the anterior pituitary (AP) proopiomelanocortin (POMC) was conducted.	Corticosterone	143-157	interleukin 1 beta	Homo sapiens	107-116
9986927-1	1999	11beta-Hydroxysteroid dehydrogenase (11beta-HSD) is the enzyme responsible for the interconversion of corticosterone (CORT) to 11-dehydrocorticosterone (11-DHC).	Corticosterone	102-116	cortistatin	Rattus norvegicus	118-122
9986920-5	1999	Following this, animals were sacrificed at times 20, 45 and 90 min postinjection and a kinetic analysis of hIL-1beta action on plasma ACTH and corticosterone (CORT) concentrations and nuclear processing of the anterior pituitary (AP) proopiomelanocortin (POMC) was conducted.	Corticosterone	159-163	interleukin 1 beta	Homo sapiens	107-116
9886996-3	1999	Rats treated with CCl4 demonstrated striking elevations of plasma corticosterone levels.	Corticosterone	66-80	C-C motif chemokine ligand 4	Rattus norvegicus	18-22
10195689-1	1999	We have previously shown that endothelin-1 (ET-1) stimulates corticosterone and aldosterone secretion by the frog adrenal gland through activation of ET(A) receptors.	Corticosterone	61-75	endothelin 1	Canis lupus familiaris	30-42
10195689-1	1999	We have previously shown that endothelin-1 (ET-1) stimulates corticosterone and aldosterone secretion by the frog adrenal gland through activation of ET(A) receptors.	Corticosterone	61-75	endothelin 1	Canis lupus familiaris	44-48
10195689-7	1999	Administration of the phospholipase C inhibitor U-73122 or the protein kinase A inhibitor H-89 to perifused frog adrenal slices significantly reduced the stimulatory effect of ET-1 on corticosterone and aldosterone secretion.	Corticosterone	184-198	endothelin 1	Canis lupus familiaris	176-180
10668425-5	1999	The expression of the 5-LO gene appears to be inhibited by the pineal hormone, melatonin, and stimulated by stress hormone glucocorticoids (e.g., corticosterone and the synthetic glucocorticoid dexamethasone).	Corticosterone	146-160	arachidonate 5-lipoxygenase	Rattus norvegicus	22-26
9878816-7	1999	Pretreatment of mice with anti-IL-6 significantly attenuated the IL-1-induced increases of plasma ACTH and corticosterone at 2 h, but not at 4 h. The IL-1-induced increases of MHPG, tryptophan and 5-HIAA in hypothalamus and brain stem were not significantly altered.	Corticosterone	107-121	interleukin 6	Mus musculus	31-35
9878816-7	1999	Pretreatment of mice with anti-IL-6 significantly attenuated the IL-1-induced increases of plasma ACTH and corticosterone at 2 h, but not at 4 h. The IL-1-induced increases of MHPG, tryptophan and 5-HIAA in hypothalamus and brain stem were not significantly altered.	Corticosterone	107-121	interleukin 1 complex	Mus musculus	65-69
10352396-6	1999	Adequate biological activity of the infused rIL-1beta was supported by elevated rectal temperature records and significant elevations of plasma corticosterone on day 14.	Corticosterone	144-158	interleukin 1 beta	Rattus norvegicus	44-53
9878816-7	1999	Pretreatment of mice with anti-IL-6 significantly attenuated the IL-1-induced increases of plasma ACTH and corticosterone at 2 h, but not at 4 h. The IL-1-induced increases of MHPG, tryptophan and 5-HIAA in hypothalamus and brain stem were not significantly altered.	Corticosterone	107-121	interleukin 1 complex	Mus musculus	150-154
10474021-10	1999	These results confirm that glycyrrhizin is able to induce hypertension, and provide evidence that it inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Corticosterone	221-235	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	137-148
9854182-1	1999	In vitro, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the interconversion of active corticosterone and inert 11-dehydrocorticosterone.	Corticosterone	108-122	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	10-66
10474021-10	1999	These results confirm that glycyrrhizin is able to induce hypertension, and provide evidence that it inhibits the transcriptions of both 11beta-HSD2 and CYP11B2 in the vasculature, leading to lower aldosterone and higher corticosterone production in vessels, and increased vasoconstrictor responses to norepinephrine.	Corticosterone	221-235	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	153-160
10338289-2	1999	In the long-term adrenalectomized rats that showed a hormone deficiency and loss of glucocorticoid receptor immunoreactivity in the forebrain, an intraperitoneal injection of corticosterone was used to elevate the serum hormone levels and recover glucocorticoid receptor immunoreactivity in the forebrain.	Corticosterone	175-189	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	84-107
9862759-5	1999	Fluoxetine produced a dose-dependent reduction in the oxytocin, ACTH, and corticosterone responses to the 5-HT1A agonist 8-hydroxy-2-(dipropylamino)tetralin (8-OH-DPAT, 50 micrograms/kg, s.c.).	Corticosterone	74-88	5-hydroxytryptamine receptor 1A	Rattus norvegicus	106-112
10421433-6	1999	We conclude that even though 8-week antagonism of CRHR1 by the non-peptide antalarmin blunts basal concentrations of ACTH and corticosterone, and affects the adrenal responsiveness to ACTH, it does not blunt the HPA response to acute stress, and it does not appear to cause stress-induced adrenal insufficiency.	Corticosterone	126-140	corticotropin releasing hormone receptor 1	Homo sapiens	50-55
10622271-3	1999	Higher levels not only of the main glucocorticoids cortisol and corticosterone, but also of their inactive oxidized forms corticosterone and 11-dehydrocorticosterone (DH-B), respectively, were detected in AV than in VC blood.	Corticosterone	122-136	DNA helicase B	Homo sapiens	167-171
10338289-2	1999	In the long-term adrenalectomized rats that showed a hormone deficiency and loss of glucocorticoid receptor immunoreactivity in the forebrain, an intraperitoneal injection of corticosterone was used to elevate the serum hormone levels and recover glucocorticoid receptor immunoreactivity in the forebrain.	Corticosterone	175-189	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	247-270
10338289-4	1999	Since the complete restoration of glucocorticoid receptor immunoreactivity was shown to depend on the presence of normal levels of both serum hormone and intracellular glucocorticoid receptors, the weak reappearance of glucocorticoid receptor immunoreactivity in any forebrain area of the long-term adrenalectomized rats that had normal serum corticosterone might reflect the low intracellular glucocorticoid receptor levels there.	Corticosterone	343-357	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	34-57
10338289-5	1999	Our results revealed a weak reappearance of glucocorticoid receptor immunoreactivity in some forebrain areas of the long-term adrenalectomized rats after corticosterone treatment; the hippocampal granule cell layer and cerebral cortex in particular showed very weak recovery of glucocorticoid receptor immunoreactivity.	Corticosterone	154-168	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	44-67
10392855-7	1999	Previous exposure to interleukin-1beta or footshocks enhanced adrenocorticotropic hormone and corticosterone responses, but did not affect the long-term locomotor sensitization to amphetamine.	Corticosterone	94-108	interleukin 1 beta	Rattus norvegicus	21-38
10362296-4	1999	In contrast to the results obtained with dexamethasone, the other two groups of corticoid injected animals did not reveal changes in total cell numbers in any of the subfields of the hippocampal formation, although in the corticosterone-treated group a reduction in the volumes of the hilus and of the stratum radiatum of the CA3 subfield was observed.	Corticosterone	222-236	carbonic anhydrase 3	Rattus norvegicus	326-329
10374908-6	1999	The exposure of dispersed inner cells to 10(-7) M glucagon plus GLP-1 completely suppressed corticosterone response to ACTH (10(-9) M).	Corticosterone	92-106	glucagon	Rattus norvegicus	64-69
10374908-8	1999	Quantitative HPLC showed that 10(-7) M glucagon or GLP-1 did not affect ACTH-stimulated pregnenolone production, evoked a slight rise in progesterone and 11-deoxycorticosterone release, and markedly reduced (by about 55%) corticosterone secretion of dispersed inner adrenocortical cells.	Corticosterone	162-176	glucagon	Rattus norvegicus	51-56
10501470-10	1999	The paraventricular nucleus of the hypothalamus exhibited expression of corticotropin-releasing factor primary transcript that was associated with a sharp increase in the plasma corticosterone levels 1h after intravenous tumor necrosis factor-alpha administration.	Corticosterone	178-192	corticotropin releasing hormone	Rattus norvegicus	72-102
10501470-10	1999	The paraventricular nucleus of the hypothalamus exhibited expression of corticotropin-releasing factor primary transcript that was associated with a sharp increase in the plasma corticosterone levels 1h after intravenous tumor necrosis factor-alpha administration.	Corticosterone	178-192	tumor necrosis factor	Rattus norvegicus	221-248
10579570-6	1999	In contrast, central corticotropin-releasing hormone antagonist potentiated plasma adrenocorticotropic hormone responses, but slightly attenuated plasma corticosterone responses to stress.	Corticosterone	153-167	corticotropin releasing hormone	Rattus norvegicus	21-52
9949305-15	1999	TDO occurs only in the liver, is highly specific for L-tryptophan and is induced by glucocorticoids which would account for the observed depletion of plasma tryptophan resulting from a tumor-associated activation of the hypothalamo-pituitary-adrenal axis (urinary corticosterone +208%, p &lt; 0.01).	Corticosterone	264-278	tryptophan 2,3-dioxygenase	Homo sapiens	0-3
10232052-1	1999	In mammalian tissues, at least two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyze the interconversion of hormonally active C11-hydroxylated corticosteroids (cortisol, corticosterone) and their inactive C11-keto metabolites (cortisone, 11-dehydrocorticosterone).	Corticosterone	192-206	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	47-54
10232052-1	1999	In mammalian tissues, at least two isozymes of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyze the interconversion of hormonally active C11-hydroxylated corticosteroids (cortisol, corticosterone) and their inactive C11-keto metabolites (cortisone, 11-dehydrocorticosterone).	Corticosterone	192-206	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	85-92
9846860-3	1998	We hypothesized that in the rat model, corticosterone potentiates the catabolic effect of TNF-alpha in amounts that by itself does not influence muscle catabolism.	Corticosterone	39-53	tumor necrosis factor	Rattus norvegicus	90-99
10465510-5	1999	The intraperitoneal (IP) injection of GIP dose-dependently raised corticosterone, but not aldosterone plasma concentration: the maximal effective dose (10 nmol/rat) elicited a twofold increase.	Corticosterone	66-80	gastric inhibitory polypeptide	Rattus norvegicus	38-41
10465510-7	1999	In contrast, GIP enhanced basal corticosterone secretion and cyclic-AMP release by dispersed inner adrenocortical cells in a concentration-dependent manner, and the maximal effective concentration (10(-7) M) evoked 1.5- and 2.4-fold rises in corticosterone and cyclic-AMP production, respectively.	Corticosterone	32-46	gastric inhibitory polypeptide	Rattus norvegicus	13-16
10465510-7	1999	In contrast, GIP enhanced basal corticosterone secretion and cyclic-AMP release by dispersed inner adrenocortical cells in a concentration-dependent manner, and the maximal effective concentration (10(-7) M) evoked 1.5- and 2.4-fold rises in corticosterone and cyclic-AMP production, respectively.	Corticosterone	242-256	gastric inhibitory polypeptide	Rattus norvegicus	13-16
10465510-9	1999	The corticosterone secretagogue action of 10(-7) M GIP was abolished by the protein kinase A (PKA) inhibitor H-89 (10(-5)M), and unaffected by CIP (10(-6)M).	Corticosterone	4-18	gastric inhibitory polypeptide	Rattus norvegicus	51-54
10465510-9	1999	The corticosterone secretagogue action of 10(-7) M GIP was abolished by the protein kinase A (PKA) inhibitor H-89 (10(-5)M), and unaffected by CIP (10(-6)M).	Corticosterone	4-18	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	76-92
10465510-9	1999	The corticosterone secretagogue action of 10(-7) M GIP was abolished by the protein kinase A (PKA) inhibitor H-89 (10(-5)M), and unaffected by CIP (10(-6)M).	Corticosterone	4-18	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	94-97
9838147-5	1998	For this purpose, we measured the basal and the stress-induced ACTH and corticosterone (CORT) response at days 4 and 12, following 24 h of maternal deprivation.	Corticosterone	72-86	cortistatin	Homo sapiens	88-92
10406076-1	1999	Glucocorticoid hormone action in target tissues is modulated by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which interconverts active cortisol and corticosterone and their inert 11-keto metabolites, cortisone and 11-dehydrocorticosterone.	Corticosterone	156-170	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	64-71
10406076-1	1999	Glucocorticoid hormone action in target tissues is modulated by 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which interconverts active cortisol and corticosterone and their inert 11-keto metabolites, cortisone and 11-dehydrocorticosterone.	Corticosterone	156-170	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	102-109
9877326-7	1998	The beta1-antagonist atenolol (1.0 micromol/l) potentiated the facilitatory effects of isoprenaline in the presence of DMI and corticosterone.	Corticosterone	127-141	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	4-9
9838097-1	1998	There is evidence suggesting the involvement of central dopamine (DA) systems in the regulation of plasma corticosterone (CORT).	Corticosterone	106-120	cortistatin	Rattus norvegicus	122-126
10069702-1	1998	In the present study the role of endogenous nitric oxide (NO) in the vasopressin-induced ACTH and corticosterone secretion was investigated in conscious rats.	Corticosterone	98-112	arginine vasopressin	Rattus norvegicus	69-80
9886563-4	1998	In this experiment the hypothesis tested was that corticosterone administration would mimic the effects of energy restriction, both on mammary gland development and on levels of p27 protein in mammary ductal epithelium.	Corticosterone	50-64	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	178-181
9886563-10	1998	Consistent with this effect, the amount of p27 protein present in ductal mammary epithelial cells increased dose-dependently in response to increasing corticosterone administration (P &lt; 0.01).	Corticosterone	151-165	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	43-46
9886563-11	1998	The hypothesis is proposed that dietary administration of corticosterone may imitate the effects of energy restriction on mammary carcinogenesis by regulation of mammary tissue size homeostasis via p27/kip1 mediated arrest of cell cycle progression.	Corticosterone	58-72	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	198-201
9886563-11	1998	The hypothesis is proposed that dietary administration of corticosterone may imitate the effects of energy restriction on mammary carcinogenesis by regulation of mammary tissue size homeostasis via p27/kip1 mediated arrest of cell cycle progression.	Corticosterone	58-72	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	202-206
9878275-6	1998	Adrenal and plasma concentrations of corticosterone increased in all three groups of animals as a direct linear function of dose of CRH.	Corticosterone	37-51	corticotropin releasing hormone	Rattus norvegicus	132-135
9878275-7	1998	Both greater levels of conditioning and larger amounts of CRH increase the synthesis of corticosterone more in SHA/Bru animals than in the SLA/Bru animals.	Corticosterone	88-102	corticotropin releasing hormone	Rattus norvegicus	58-61
9862910-9	1998	Because BK-induced PE is dependent on both polymorphonuclear leukocytes and phospholipase A2 activity, we tested the hypothesis that the action of corticosterone to inhibit BK-induced PE is mediated by stimulating the production and release of annexin I.	Corticosterone	147-161	phospholipase A2 group IB	Rattus norvegicus	76-92
9862910-9	1998	Because BK-induced PE is dependent on both polymorphonuclear leukocytes and phospholipase A2 activity, we tested the hypothesis that the action of corticosterone to inhibit BK-induced PE is mediated by stimulating the production and release of annexin I.	Corticosterone	147-161	annexin A1	Rattus norvegicus	244-253
9862910-11	1998	Co-perfusion of BK with annexin I (100 ng/ml) through the knee joint mimics the inhibition of BK-induced PE produced by noxious electrical stimulation or by intravenous corticosterone.	Corticosterone	169-183	annexin A1	Rattus norvegicus	24-33
9862910-12	1998	Co-perfusion of BK with annexin I antibody (LCPS1, 1:60 dilution) prevented the inhibition of BK-induced PE produced by noxious electrical stimulation or intravenous corticosterone adminstration.	Corticosterone	166-180	annexin A1	Rattus norvegicus	24-33
10069701-0	1998	Effect of L-NAME, a specific nitric oxide synthase inhibitor, on corticotropin-releasing hormone-elicited ACTH and corticosterone secretion.	Corticosterone	115-129	corticotropin releasing hormone	Rattus norvegicus	65-96
10069701-1	1998	This study was designed to determine the role of endogenous nitric oxide (NO) in the corticotropin-releasing hormone (CRH)-induced ACTH and corticosterone secretion, as well as possible involvement of hypothalamic dopamine and noradrenaline in that secretion in conscious rats.	Corticosterone	140-154	corticotropin releasing hormone	Rattus norvegicus	85-116
10069701-1	1998	This study was designed to determine the role of endogenous nitric oxide (NO) in the corticotropin-releasing hormone (CRH)-induced ACTH and corticosterone secretion, as well as possible involvement of hypothalamic dopamine and noradrenaline in that secretion in conscious rats.	Corticosterone	140-154	corticotropin releasing hormone	Rattus norvegicus	118-121
10069701-6	1998	totally abolished the CRH-elicited ACTH and corticosterone secretion, indicating a predominantly pituitary site of CRH-evoked stimulation.	Corticosterone	44-58	corticotropin releasing hormone	Rattus norvegicus	22-25
9853126-3	1998	We report that non-invasive administration of corticosterone in the drinking water (400 micrograms/ml) also produced atrophy of apical dendrites in CA3.	Corticosterone	46-60	carbonic anhydrase 3	Rattus norvegicus	148-151
10069701-12	1998	L-arginine also significantly reversed the L-NAME-evoked increase in the CRH-induced ACTH and corticosterone secretion.	Corticosterone	94-108	corticotropin releasing hormone	Rattus norvegicus	73-76
9824681-0	1998	Downregulation of BDNF mRNA and protein in the rat hippocampus by corticosterone.	Corticosterone	66-80	brain-derived neurotrophic factor	Rattus norvegicus	18-22
9824681-1	1998	Previously, we showed that corticosterone regulates BDNF mRNA levels in the hippocampus.	Corticosterone	27-41	brain-derived neurotrophic factor	Rattus norvegicus	52-56
9824681-10	1998	At both time points, a decrease in BDNF protein was observed; 17% at 4 h and 14% at 6 h after corticosterone, as compared to the vehicle injected controls.	Corticosterone	94-108	brain-derived neurotrophic factor	Rattus norvegicus	35-39
9824681-13	1998	In conclusion, we have found a transient, dose-dependent decrease in BDNF mRNA and protein in the hippocampus, which may underly changes in neuronal plasticity in the hippocampus after short-term changes in corticosterone concentrations.	Corticosterone	207-221	brain-derived neurotrophic factor	Rattus norvegicus	69-73
9813238-7	1998	alpha-MSH(1-13) blocked IS-induced increased CBT, increased plasma corticosterone (CORT), decreased CBG, aphagia and adipsia 24 h after IS.	Corticosterone	67-81	proopiomelanocortin	Rattus norvegicus	0-9
9834972-1	1998	The effects of xenobiotics on CYP11B1-dependent corticosterone synthesis (11 beta-hydroxylase) in mouse adrenocortical Y1 cells were studied.	Corticosterone	48-62	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	30-37
9795377-10	1998	In addition, with leptin administration there is a decrease in leptin gene expression in WAT, independent of food intake and serum insulin and corticosterone concentrations.	Corticosterone	143-157	leptin	Rattus norvegicus	18-24
9762014-3	1998	Both the anti-IL-6-antibody- and control-antibody-pretreated mice showed the same extent of plasma ACTH and corticosterone increases during stress, and no significant difference was found between the two groups of animals.	Corticosterone	108-122	interleukin 6	Mus musculus	14-18
9822947-8	1998	Leptin lowered glycemia and insulinemia of obese mice to lean levels and decreased plasma corticosterone.	Corticosterone	90-104	leptin	Mus musculus	0-6
9751508-7	1998	This effect of leptin was also observed in rat primary adrenocortical cells, where leptin inhibited stimulated corticosterone secretion in a dose-dependent manner (down by 46 +/- 0.1% of controls with the highest leptin dose, P &lt; 0.001 vs. CT).	Corticosterone	111-125	leptin	Rattus norvegicus	15-21
10024939-7	1998	However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha.	Corticosterone	17-31	negative elongation factor complex member C/D, Th1l	Mus musculus	140-143
10024939-7	1998	However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha.	Corticosterone	17-31	interleukin 1 alpha	Mus musculus	223-233
10024939-7	1998	However when the corticosterone and the anti-glucocorticoid (AED or DHEA) were co-administered, there was protection, with restoration of a Th1-dominated cytokine profile, enhanced DTH responses, and enhanced expression of IL-1 alpha and TNF alpha.	Corticosterone	17-31	tumor necrosis factor	Mus musculus	238-247
9756522-7	1998	Leptin also prevented the elevations in serum corticosterone and ketones found in pair-fed lean mice.	Corticosterone	46-60	leptin	Mus musculus	0-6
9776137-0	1998	Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone-replacement.	Corticosterone	112-126	solute carrier family 6 member 3	Homo sapiens	24-44
9751508-7	1998	This effect of leptin was also observed in rat primary adrenocortical cells, where leptin inhibited stimulated corticosterone secretion in a dose-dependent manner (down by 46 +/- 0.1% of controls with the highest leptin dose, P &lt; 0.001 vs. CT).	Corticosterone	111-125	leptin	Rattus norvegicus	83-89
9751508-7	1998	This effect of leptin was also observed in rat primary adrenocortical cells, where leptin inhibited stimulated corticosterone secretion in a dose-dependent manner (down by 46 +/- 0.1% of controls with the highest leptin dose, P &lt; 0.001 vs. CT).	Corticosterone	111-125	leptin	Rattus norvegicus	83-89
9792213-12	1998	Because cell-associated lipocortin 1 levels are under the partial control of corticosterone (endogenous circulating glucocorticoid hormone in rodents) and dexamethasone (a synthetic glucocorticoid hormone with a potent anti-inflammatory profile), a model is proposed in which a balance between anti-inflammatory (lipocortin 1, etc.)	Corticosterone	77-91	annexin A1	Homo sapiens	24-36
9865851-5	1998	Corticosterone (CORT)-like immunoreactivities were significantly elevated by halothane in all experimental groups, and in the 2- and 24-h groups following methoxyflurane exposure.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
9739115-4	1998	Intravenously administered of UCN (5 microg/kg) increased ACTH and corticosterone secretion.	Corticosterone	67-81	urocortin	Rattus norvegicus	30-33
9736665-5	1998	Corticosterone (CORT) replacement normalized GR mRNA expression, whereas high doses slightly decreased GR mRNA in CA1.	Corticosterone	0-14	cortistatin	Homo sapiens	16-20
9728091-3	1998	At a dose of 5 mg/kg, which also caused body weight loss, leptin potentiated the induction by IL-1 of serum corticosterone and IL-6 but did not show any other activity.	Corticosterone	108-122	leptin	Mus musculus	58-64
9728091-3	1998	At a dose of 5 mg/kg, which also caused body weight loss, leptin potentiated the induction by IL-1 of serum corticosterone and IL-6 but did not show any other activity.	Corticosterone	108-122	interleukin 1 complex	Mus musculus	94-98
9724035-4	1998	2) Does corticosterone modulate mechanisms regulating CRH gene expression during sustained stress?	Corticosterone	8-22	corticotropin releasing hormone	Rattus norvegicus	54-57
9724036-0	1998	Corticosterone can facilitate as well as inhibit corticotropin-releasing hormone gene expression in the rat hypothalamic paraventricular nucleus.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	49-80
9724036-1	1998	We have used in situ hybridization to investigate how basal levels of circulating corticosterone modulate CRH gene transcription in the neuroendocrine parvicellular part of the hypothalamic paraventricular nucleus (PVHmpd) during sustained hypovolemia.	Corticosterone	82-96	corticotropin releasing hormone	Rattus norvegicus	106-109
9724036-2	1998	In the absence of the stressor, the accumulation rate of the CRH primary transcript exhibited a dose dependency on low maintained levels of plasma corticosterone similar to that previously reported for the mature messenger RNA (mRNA); levels declined as plasma corticosterone increased.	Corticosterone	147-161	corticotropin releasing hormone	Rattus norvegicus	61-64
9724036-2	1998	In the absence of the stressor, the accumulation rate of the CRH primary transcript exhibited a dose dependency on low maintained levels of plasma corticosterone similar to that previously reported for the mature messenger RNA (mRNA); levels declined as plasma corticosterone increased.	Corticosterone	261-275	corticotropin releasing hormone	Rattus norvegicus	61-64
9724036-3	1998	In response to hypovolemia, the absence of corticosterone compromised CRH gene transcription mechanisms to mount the activated response seen in intact animals.	Corticosterone	43-57	corticotropin releasing hormone	Rattus norvegicus	70-73
9724036-7	1998	These results suggest that corticosterone affects CRH gene transcription in the PVHmpd using two mechanisms: first, inhibition, which probably uses type II glucocorticoid receptor-dependent mechanisms and contributes to classic negative feedback; and second, facilitation, which is seen at low plasma concentrations and maintains gene transcription in the presence of sustained stress, possibly using type I mechanisms.	Corticosterone	27-41	corticotropin releasing hormone	Rattus norvegicus	50-53
9724056-0	1998	Leptin and corticosterone have opposite effects on food intake and the expression of UCP1 mRNA in brown adipose tissue of lep(ob)/lep(ob) mice.	Corticosterone	11-25	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	85-89
9724056-0	1998	Leptin and corticosterone have opposite effects on food intake and the expression of UCP1 mRNA in brown adipose tissue of lep(ob)/lep(ob) mice.	Corticosterone	11-25	leptin	Mus musculus	122-125
9724056-0	1998	Leptin and corticosterone have opposite effects on food intake and the expression of UCP1 mRNA in brown adipose tissue of lep(ob)/lep(ob) mice.	Corticosterone	11-25	leptin	Mus musculus	130-133
9724056-4	1998	The results also emphasize the abilities of leptin and corticosterone to respectively increase and reduce the expression of UCP1 mRNA in IBAT.	Corticosterone	55-69	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	124-128
9724056-5	1998	The effects of leptin and corticosterone on food intake and the expression of UCP1 mRNA translated into effects on body weight and body composition; leptin reduced body weight and corticosterone increased the weight of IBAT.	Corticosterone	26-40	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	78-82
9724056-7	1998	Corticosterone increased food intake and reduced the expression of IBAT UCP1 regardless of the leptin status, and leptin reduced food intake and induced the expression of IBAT UCP1 independently of the corticosterone levels.	Corticosterone	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	72-76
9831175-5	1998	Treatment with dexamethasone (DEX) prior to the administration of IL-1beta prevented the CS increase, diminished the CA increase and enhanced AChE activity in nerve fibers, and led to inhibition of the proliferative response of thymocytes to mitogen.	Corticosterone	89-91	interleukin 1 beta	Rattus norvegicus	66-74
9831177-6	1998	In vivo, recombinant rat IL-1alpha and IL-1beta enhanced body temperature, increased plasma levels of corticosterone and ACTH, and depressed social behaviour.	Corticosterone	102-116	interleukin 1 alpha	Rattus norvegicus	25-34
9831177-6	1998	In vivo, recombinant rat IL-1alpha and IL-1beta enhanced body temperature, increased plasma levels of corticosterone and ACTH, and depressed social behaviour.	Corticosterone	102-116	interleukin 1 beta	Rattus norvegicus	39-47
9758169-10	1998	Our findings reveal the complex action of corticosterone in modulating the expression of PSA-NCAM in the gyrus dentatus of the hippocampal formation.	Corticosterone	42-56	neural cell adhesion molecule 1	Rattus norvegicus	93-97
9744483-1	1998	Age-appropriate acute stress, such as cold exposure, provokes the secretion of corticotropin releasing factor (CRF) from the hypothalamus, leading to a robust increase of plasma corticosterone in the immature rat.	Corticosterone	178-192	corticotropin releasing hormone	Rattus norvegicus	79-109
9705523-3	1998	In contrast, no recombinase activity was detected in the absence of ligand or in the presence of the natural GR ligands corticosterone, cortisol or aldosterone.	Corticosterone	120-134	nuclear receptor subfamily 3, group C, member 1	Mus musculus	109-111
9753655-6	1998	Kinetic analysis of equivalent amounts of wild type and mutant proteins showed that mutagenesis of active site Serines resulted in modest increases of Km values for corticosterone from 325 nM for 11 beta HSD1 to 512 nM-588 nM for the S1 (YAASK), S2 (YSAGK) and S3 (YAAGK) mutants in homogenates of transfected CHOP cells.	Corticosterone	165-179	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	196-208
9748512-0	1998	Neuropeptide Y in relation to carbohydrate intake, corticosterone and dietary obesity.	Corticosterone	51-65	neuropeptide Y	Rattus norvegicus	0-14
9748512-8	1998	Together with NPY, circulating corticosterone (CORT) levels are also highest in a high-carbohydrate condition and positively correlated with NPY in the ARC.	Corticosterone	31-45	neuropeptide Y	Rattus norvegicus	14-17
9748512-8	1998	Together with NPY, circulating corticosterone (CORT) levels are also highest in a high-carbohydrate condition and positively correlated with NPY in the ARC.	Corticosterone	31-45	cortistatin	Rattus norvegicus	47-51
9748512-8	1998	Together with NPY, circulating corticosterone (CORT) levels are also highest in a high-carbohydrate condition and positively correlated with NPY in the ARC.	Corticosterone	31-45	neuropeptide Y	Rattus norvegicus	141-144
9688689-6	1998	Intraperitoneal alpha-MSH also suppressed the LPS-induced rise in plasma IL-6, ACTH, and corticosterone (CS) levels.	Corticosterone	89-103	proopiomelanocortin	Rattus norvegicus	16-25
9756545-4	1998	These results show that the increase in corticosterone levels after immunization with MBP can be dissociated from the stress of the paralytic attack that characterizes EAE.	Corticosterone	40-54	myelin basic protein	Rattus norvegicus	86-89
9700103-4	1998	HDC transcripts were decreased approximately 73% with dexamethasone treatment, 57% with corticosterone treatment, and 50% with exposure to 10% oxygen.	Corticosterone	88-102	histidine decarboxylase	Rattus norvegicus	0-3
9700103-5	1998	Likewise, HDC enzyme activity was decreased 80% by treatment with dexamethasone and corticosterone and 60% by exposure to 10% oxygen.	Corticosterone	84-98	histidine decarboxylase	Rattus norvegicus	10-13
9688693-3	1998	We therefore analyzed sleep architecture and electroencephalographic (EEG) power in freely moving rats before and after removal of corticosterone (thus elevating endogenous CRH) by surgical adrenalectomy.	Corticosterone	131-145	corticotropin releasing hormone	Rattus norvegicus	173-176
9688689-6	1998	Intraperitoneal alpha-MSH also suppressed the LPS-induced rise in plasma IL-6, ACTH, and corticosterone (CS) levels.	Corticosterone	105-107	proopiomelanocortin	Rattus norvegicus	16-25
9688689-7	1998	Intracerebroventricular injection of SHU-9119, a potent melanocortin-4 receptor (MC4-R)/MC3-R antagonist, completely blocked the antipyretic effect of intraperitoneal alpha-MSH during the first 4 h after LPS but had no effect on alpha-MSH-induced suppression of LPS-stimulated plasma IL-6 and CS levels.	Corticosterone	293-295	proopiomelanocortin	Rattus norvegicus	167-176
9688689-9	1998	In contrast, the inhibition of LPS-induced increases in plasma CS and IL-6 levels by intraperitoneal alpha-MSH appears to be mediated by a different mechanism(s), and these effects do not contribute to its antipyretic action.	Corticosterone	63-65	proopiomelanocortin	Rattus norvegicus	101-110
9888510-7	1998	In accordance with the effects of ACTH on PTP activity, cell permeable PTP inhibitors block ACTH stimulation on adrenal zona fasciculata (ZF) cells: ACTH (1 nM) = 108.2 +/- 3.5 ng corticosterone/10(5) cells vs. ACTH + phenylarsine oxide (2 nM) = 60 +/- 4 (P &lt; 0.001) and ACTH + pervanadate (10 mM) = 68 +/- 2 (P &lt; 0.01).	Corticosterone	180-194	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	71-74
9705578-0	1998	Role of corticotropin-releasing hormone in gastrin-releasing peptide-mediated regulation of corticotropin and corticosterone secretion in male rats.	Corticosterone	110-124	corticotropin releasing hormone	Rattus norvegicus	8-39
9705578-0	1998	Role of corticotropin-releasing hormone in gastrin-releasing peptide-mediated regulation of corticotropin and corticosterone secretion in male rats.	Corticosterone	110-124	gastrin releasing peptide	Rattus norvegicus	43-68
9705578-5	1998	The highest dose (100 ng/rat) of GRP increased plasma ACTH and corticosterone 4- and 14-fold, respectively.	Corticosterone	63-77	gastrin releasing peptide	Rattus norvegicus	33-36
9705578-9	1998	By using alpha-helical (9-41) corticotropin-releasing factor (CRF), a competitive antagonist of CRF, the role of CRF on GRP-induced ACTH and corticosterone secretion was also explored.	Corticosterone	141-155	gastrin releasing peptide	Rattus norvegicus	120-123
9705578-10	1998	alpha-Helical (9-41) CRF (10 microg/rat) blocked the increase in ACTH and corticosterone secretion induced by GRP (10 ng).	Corticosterone	74-88	gastrin releasing peptide	Rattus norvegicus	110-113
9705578-11	1998	The results obtained in this study suggest that GRP increases the secretion of ACTH and corticosterone in the plasma by acting centrally on GRP receptors, and that endogenous GRP receptor ligands do not tonically regulate ACTH and corticosterone secretion.	Corticosterone	88-102	gastrin releasing peptide	Rattus norvegicus	48-51
9745935-0	1998	Decreases in brain glial fibrillary acidic protein (GFAP) are associated with increased serum corticosterone following inhalation exposure to toluene.	Corticosterone	94-108	glial fibrillary acidic protein	Rattus norvegicus	19-50
9745935-0	1998	Decreases in brain glial fibrillary acidic protein (GFAP) are associated with increased serum corticosterone following inhalation exposure to toluene.	Corticosterone	94-108	glial fibrillary acidic protein	Rattus norvegicus	52-56
9745935-6	1998	Serum Corticosterone was significantly elevated in the same rats that exhibited decreases in brain GFAP concentration.	Corticosterone	6-20	glial fibrillary acidic protein	Rattus norvegicus	99-103
9761458-2	1998	Intravenous (iv) or intraperitoneal (ip) injection of mIL-6 caused a rapid and short-lived activation of the hypothalamo-pituitary-adrenocortical (HPA) axis, as indicated by increases in plasma ACTH and corticosterone, with peak responses around 30-60 min.	Corticosterone	203-217	interleukin 6	Mus musculus	54-59
9700972-5	1998	Intrahippocampal injection of 1 ng of A-MR or A-GR prevented the return to basal corticosterone levels observed 90 min after restraint stress.	Corticosterone	81-95	G protein-coupled receptor 182	Homo sapiens	38-42
9700972-7	1998	The results are discussed in light of recent findings implicating the role of the MR in the hippocampus in adaptive behavioral responses to an aversive or threatening environment, and further implicate the permissive role of corticosterone in A-MR-induced behavioral responses.	Corticosterone	225-239	G protein-coupled receptor 182	Homo sapiens	243-247
9685591-0	1998	Circadian rhythm of Arg-vasopressin contents in the suprachiasmatic nucleus in relation to corticosterone.	Corticosterone	91-105	arginine vasopressin	Homo sapiens	20-35
9826789-1	1998	We have studied the immediate and long-term effects of high doses of corticosterone (CORT) on mRNA expression and binding properties of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and spinal cord of rats.	Corticosterone	69-83	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	136-162
9826789-1	1998	We have studied the immediate and long-term effects of high doses of corticosterone (CORT) on mRNA expression and binding properties of mineralocorticoid receptor and glucocorticoid receptor in the hippocampus and spinal cord of rats.	Corticosterone	69-83	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	167-190
9826789-3	1998	Major results show that corticosterone treatment reduces mineralocorticoid and glucocorticoid receptor maximum binding capacity (Bmax) in both the hippocampus and spinal cord and that this reduction is partially reversed after cessation of treatment.	Corticosterone	24-38	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	79-102
9726650-2	1998	5-HT1A receptor agonists, including flesinoxan, increase corticosterone (B) levels in the blood and reduces 5-HT1A receptor mRNA expression in the hippocampus.	Corticosterone	57-71	5-hydroxytryptamine receptor 1A	Rattus norvegicus	0-6
9726650-3	1998	In this study, we examined whether the 5-HT1A receptor downregulation induced by flesinoxan involves corticosterone control of 5-HT1A receptor gene transcription.	Corticosterone	101-115	5-hydroxytryptamine receptor 1A	Rattus norvegicus	39-45
9726650-3	1998	In this study, we examined whether the 5-HT1A receptor downregulation induced by flesinoxan involves corticosterone control of 5-HT1A receptor gene transcription.	Corticosterone	101-115	5-hydroxytryptamine receptor 1A	Rattus norvegicus	127-133
9726650-7	1998	Flesinoxan injection also caused a dose-dependent decrease of 5-HT1A mRNA in the dentate gyrus of adrenalectomized animals with corticosterone replacement.	Corticosterone	128-142	5-hydroxytryptamine receptor 1A	Rattus norvegicus	62-68
9679962-11	1998	The physiological glucocorticoid substrates of 11beta-HSD 1 (corticosterone and dehydrocorticosterone) and the selective 11beta-HSD 1 inhibitor glycyrrhetinic acid turned out to be strong inhibitors of NNK carbonyl reduction, displaying Ki values of 37.8, 21.3, and 10.9 microM, respectively.	Corticosterone	61-75	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	47-59
9706007-11	1998	The gradual emergence of increased AVP transcription at a time of diminishing CRH response suggests that repeated stress results in a specific facilitation of AVP gene expression, perhaps by impairment of corticosterone feedback.	Corticosterone	205-219	arginine vasopressin	Rattus norvegicus	35-38
9670995-0	1998	Age-dependent loss of corticosterone modulation of central serotonin 5-HT1A receptor binding sites.	Corticosterone	22-36	5-hydroxytryptamine receptor 1A	Rattus norvegicus	59-84
9670995-1	1998	A loss of endocrine and neurotransmitter system interactions, including corticosterone regulation of 5-HT1A receptors, may underlie the age-related deficits in the hypothalamic-pituitary-adrenal (HPA) axis including adapting to stress.	Corticosterone	72-86	5-hydroxytryptamine receptor 1A	Rattus norvegicus	101-107
9670995-7	1998	An additional indicator of the hippocampal response to corticosterone, the distribution of glial fibrillary acidic protein (GFAP), revealed an age-related decline in responsiveness to hormone treatment in the oldest group.	Corticosterone	55-69	glial fibrillary acidic protein	Rattus norvegicus	91-122
9670995-7	1998	An additional indicator of the hippocampal response to corticosterone, the distribution of glial fibrillary acidic protein (GFAP), revealed an age-related decline in responsiveness to hormone treatment in the oldest group.	Corticosterone	55-69	glial fibrillary acidic protein	Rattus norvegicus	124-128
9670995-8	1998	The present study has identified an age-associated deficit in the regulation of hippocampal 5-HT1A receptors by corticosterone which may underly the diminished capacity of the aging HPA axis to cope with stress.	Corticosterone	112-126	5-hydroxytryptamine receptor 1A	Rattus norvegicus	92-98
9712410-6	1998	ET-1 evoked significant rises in the blood levels of aldosterone and corticosterone at both 30 and 60 min.	Corticosterone	69-83	endothelin 1	Rattus norvegicus	0-4
9920681-3	1998	By reviewing the work carried out in different learning models in chicks (passive avoidance learning) and rats (spatial orientation in the Morris water maze and contextual fear conditioning), a role for brain corticosterone action through the glucocorticoid receptor type on the mechanisms of memory consolidation is hypothesized.	Corticosterone	209-223	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	243-266
9787267-3	1998	The aim of the present paper was to investigate the effect of mineralocorticoid receptor (MR) blockade on the expression of aggressive behaviour at the beginning of the dark phase, when MRs are mostly occupied due to the diurnal peak of corticosterone secretion.	Corticosterone	237-251	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	62-88
9787267-3	1998	The aim of the present paper was to investigate the effect of mineralocorticoid receptor (MR) blockade on the expression of aggressive behaviour at the beginning of the dark phase, when MRs are mostly occupied due to the diurnal peak of corticosterone secretion.	Corticosterone	237-251	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	90-92
9663558-0	1998	Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy.	Corticosterone	16-30	interleukin 1 beta	Homo sapiens	67-75
9609704-4	1998	Under steady-state reaction conditions, the interaction of P45011 beta with P450scc stimulates the production of corticosterone from deoxycorticosterone by about 10-fold but inhibits further reactions from corticosterone.	Corticosterone	113-127	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	76-83
9609704-4	1998	Under steady-state reaction conditions, the interaction of P45011 beta with P450scc stimulates the production of corticosterone from deoxycorticosterone by about 10-fold but inhibits further reactions from corticosterone.	Corticosterone	138-152	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	76-83
9609704-5	1998	The rapid-quenching experiments showed, however, that the rate constant for the 11 beta-hydroxylation of deoxycorticosterone for corticosterone production in the presence of P450scc was almost the same as that without P450scc.	Corticosterone	110-124	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	174-181
9609704-5	1998	The rapid-quenching experiments showed, however, that the rate constant for the 11 beta-hydroxylation of deoxycorticosterone for corticosterone production in the presence of P450scc was almost the same as that without P450scc.	Corticosterone	110-124	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	218-225
9609704-6	1998	The interaction of P45011 beta with P450scc in the reaction system for deoxycorticosterone metabolism was found to slow the rate of the subsequent 18-hydroxylation of the produced corticosterone and to accelerate the dissociation of the corticosterone from P45011 beta, which stimulated the corticosterone production and inhibited the further reaction for aldosterone synthesis in the steady-state reaction.	Corticosterone	76-90	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	36-43
9609704-6	1998	The interaction of P45011 beta with P450scc in the reaction system for deoxycorticosterone metabolism was found to slow the rate of the subsequent 18-hydroxylation of the produced corticosterone and to accelerate the dissociation of the corticosterone from P45011 beta, which stimulated the corticosterone production and inhibited the further reaction for aldosterone synthesis in the steady-state reaction.	Corticosterone	180-194	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	36-43
9609704-6	1998	The interaction of P45011 beta with P450scc in the reaction system for deoxycorticosterone metabolism was found to slow the rate of the subsequent 18-hydroxylation of the produced corticosterone and to accelerate the dissociation of the corticosterone from P45011 beta, which stimulated the corticosterone production and inhibited the further reaction for aldosterone synthesis in the steady-state reaction.	Corticosterone	180-194	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	36-43
9607777-2	1998	Acute treatment of rats with the selective mineralocorticoid receptor antagonist, RU28318 (50 mg/kg sc), produced elevated basal corticosterone levels in the morning, but had no effect on basal corticosterone levels in the evening or on restraint stress corticosterone levels at either time of day.	Corticosterone	129-143	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	43-69
9607777-7	1998	We conclude that mineralocorticoid receptor activation is necessary and sufficient to maintain low basal corticosterone levels during the circadian trough, whereas glucocorticoid receptor activation is necessary to constrain corticosterone secretion during the circadian peak or during acute stress.	Corticosterone	105-119	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	17-43
9607777-8	1998	However, even during the circadian peak or acute stress, mineralocorticoid receptor activation plays an important role in facilitating the glucocorticoid receptor dependent regulation of HPA axis activity by corticosterone.	Corticosterone	208-222	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	57-83
9785114-2	1998	In Experiment 1, we examined changes in plasma corticosterone (CORT) levels as a possible mechanism for the effects of isolation.	Corticosterone	47-61	cortistatin	Rattus norvegicus	63-67
9681879-2	1998	Intake of low protein diet (LPD) (5%) for short-term period of seven consecutive days (STP) increased the plasma and adrenal corticosterone level in 6 month old rats only and decreased only the adrenal corticosterone level in 9, 12 and 18 month old rats.	Corticosterone	125-139	thyroid hormone receptor interactor 10	Rattus norvegicus	87-90
9681879-2	1998	Intake of low protein diet (LPD) (5%) for short-term period of seven consecutive days (STP) increased the plasma and adrenal corticosterone level in 6 month old rats only and decreased only the adrenal corticosterone level in 9, 12 and 18 month old rats.	Corticosterone	202-216	thyroid hormone receptor interactor 10	Rattus norvegicus	87-90
9681879-5	1998	High protein diet (HPD) (40%) consumption under STP conditions decreased the plasma corticosterone level in 3 month old rats and increased the same in 6 month old rats.	Corticosterone	84-98	thyroid hormone receptor interactor 10	Rattus norvegicus	48-51
9629304-2	1998	Activation of the HPA axis or treatment of macrophages from susceptible mice with corticosterone suppresses the expression of Nramp1 mRNA and results in an increased susceptibility to mycobacterial growth.	Corticosterone	82-96	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	126-132
9629304-5	1998	Thus, corticosterone induced the accelerated degradation of Nramp1 mRNA as well as mRNA of several other macrophage activation genes in macrophages from BCG-susceptible mice.	Corticosterone	6-20	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	60-66
9629304-6	1998	Treatment of macrophages with corticosterone before the induction of Nramp1 resulted in the accelerated degradation of mRNA in macrophages from both resistant and susceptible mice.	Corticosterone	30-44	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	69-75
9629304-7	1998	The Nramp1 gene product appears to protect the mRNA of macrophage activation genes from degradation induced by corticosterone by an iron-dependent mechanism.	Corticosterone	111-125	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	4-10
9648235-3	1998	The concentrations of interleukin-5 and -10 in spleen cells stimulated in vitro with concanavalin A were significantly higher in the mice with B6 deficiency, as was their plasma corticosterone concentrations.	Corticosterone	178-192	interleukin 5	Mus musculus	22-43
9721940-3	1998	CNP did not affect basal corticosterone secretion in the doses applied, but inhibited in a dose-dependent manner the increase in plasma corticosterone induced by ether stress, electric shock and restraint.	Corticosterone	136-150	natriuretic peptide C	Rattus norvegicus	0-3
9663558-0	1998	Thermogenic and corticosterone responses to intravenous cytokines (IL-1beta and TNF-alpha) are attenuated by subdiaphragmatic vagotomy.	Corticosterone	16-30	tumor necrosis factor	Homo sapiens	80-89
9698199-1	1998	Corticosterone influences 5-HT1A receptor-mediated responses in the rat hippocampus in vitro: activation of the high affinity mineralocorticoid receptor suppresses 5-HT1A receptor-mediated hyperpolarization, while subsequent activation of lower affinity glucocorticoid receptors enhances the effect of 5-HT.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	126-152
9611156-5	1998	Compared with a 10% fat diet, a 30% fat diet is associated with a decline in insulin and corticosterone (CORT) levels, whereas a 60% fat diet produces an increase in circulating glucose.	Corticosterone	89-103	cortistatin	Rattus norvegicus	105-109
9622630-5	1998	A significant reduction in the number of neurons and in the volumes of the layers of the dentate gyrus and CA3 hippocampal field was found in rats exposed to glucocorticoids in the neonatal period; furthermore, animals treated with corticosterone from birth until 180 days of age had also a reduction in the volume of the stratum radiatum of the CA1 hippocampal field.	Corticosterone	232-246	carbonic anhydrase 3	Rattus norvegicus	107-110
9622630-5	1998	A significant reduction in the number of neurons and in the volumes of the layers of the dentate gyrus and CA3 hippocampal field was found in rats exposed to glucocorticoids in the neonatal period; furthermore, animals treated with corticosterone from birth until 180 days of age had also a reduction in the volume of the stratum radiatum of the CA1 hippocampal field.	Corticosterone	232-246	carbonic anhydrase 1	Rattus norvegicus	346-349
9773504-13	1998	The serum level of corticosterone was also increased (P &lt; 0.01) at the time of beta-endorphin release.	Corticosterone	19-33	pro-opiomelanocortin-alpha	Mus musculus	82-96
10330521-6	1998	At the age of seven months the stimulated CS levels induced by an acute stress (novel environment) were lower in rats treated neonatally with IL-1 than in controls (P&lt;0.01).	Corticosterone	42-44	interleukin 1 beta	Homo sapiens	142-146
9620773-4	1998	Here we show that in mice lacking Crhr1, the medulla of the adrenal gland is atrophied and stress-induced release of adrenocorticotropic hormone (ACTH) and corticosterone is reduced.	Corticosterone	156-170	corticotropin releasing hormone receptor 1	Mus musculus	34-39
10780884-10	1998	Importantly, anti-MIF Ab treatment caused a significant increase in endogenous serum corticosterone levels, which correlated with the reversal of disease parameters.	Corticosterone	85-99	macrophage migration inhibitory factor	Rattus norvegicus	18-21
9676895-6	1998	In addition to the behavioral variations, IL-1beta dose-dependently increased plasma ACTH and corticosterone concentrations, and also induced several central monoamine alterations.	Corticosterone	94-108	interleukin 1 beta	Mus musculus	42-50
9593773-8	1998	The increased hepatic GR expression may be crucial, since rats exposed to dexamethasone in utero showed potentiated glucose responses to exogenous corticosterone.	Corticosterone	147-161	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	22-24
9629243-5	1998	We have also compared the magnitude of the increase in corticosterone levels induced by IL-1 in 3-day-old and adult mice to that caused by acute stress.	Corticosterone	55-69	interleukin 1 complex	Mus musculus	88-92
9629243-6	1998	IL-1 beta and acute stress caused a comparable increase in corticosterone levels in adult mice.	Corticosterone	59-73	interleukin 1 beta	Mus musculus	0-9
9629243-7	1998	In newborn mice, however, IL-1 beta, but not restraint or cold stress, stimulated corticosterone output.	Corticosterone	82-96	interleukin 1 beta	Mus musculus	26-35
9629243-8	1998	Thus, IL-1 beta can elicit a corticosterone response during the postnatal stress-hyporesponsive period.	Corticosterone	29-43	interleukin 1 beta	Mus musculus	6-15
9629243-9	1998	Furthermore, when the corticosterone levels attained following IL-1 beta administration were compared to the basal levels of the hormone at a given age, the increase in plasma corticosterone levels was several fold higher in newborn than in adult animals.	Corticosterone	22-36	interleukin 1 beta	Mus musculus	63-72
9629243-9	1998	Furthermore, when the corticosterone levels attained following IL-1 beta administration were compared to the basal levels of the hormone at a given age, the increase in plasma corticosterone levels was several fold higher in newborn than in adult animals.	Corticosterone	176-190	interleukin 1 beta	Mus musculus	63-72
9564823-8	1998	injection of 100 ng IL-1beta increased plasma ACTH and corticosterone levels after 1 h (P &lt; 0.02).	Corticosterone	55-69	interleukin 1 beta	Mus musculus	20-28
9564823-10	1998	In comparison to wild-type (+/+) B6D2F1 mice, LIF knockout mice with a deleted LIF gene (-/-) exhibited decreased plasma ACTH (631 +/- 61 vs. 376 +/- 50 pg/ml; P &lt; 0.01) and corticosterone (783 +/- 85 vs. 433 +/- 51 ng/ml; P &lt; 0.01) levels 1 h after i.p.	Corticosterone	177-191	leukemia inhibitory factor	Mus musculus	46-49
9564824-9	1998	Injection of 12 microg murine LIF to LIFKO and normal C57BL/6 animals resulted in increased plasma ACTH and corticosterone levels and elevated pituitary POMC mRNA levels in both LIF-repleted and LIF-depleted mice.	Corticosterone	108-122	leukemia inhibitory factor	Mus musculus	30-33
9685591-4	1998	The circadian rhythms of AVP in the SCN in relation to the plasma corticosterone and locomotor activity were investigated.	Corticosterone	66-80	arginine vasopressin	Homo sapiens	25-28
9685591-5	1998	Under the light-dark cycle, plasma corticosterone levels were reciprocally correlated with the AVP content in the SCN.	Corticosterone	35-49	arginine vasopressin	Homo sapiens	95-98
9738700-6	1998	In contrast, the blood level of corticosterone was markedly enhanced by both doses of leptin at 60 and 120 min.	Corticosterone	32-46	leptin	Rattus norvegicus	86-92
9685591-7	1998	The correlation of AVP with plasma corticosterone is different at different times of the day both under the LD cycle and constant dim light.	Corticosterone	35-49	arginine vasopressin	Homo sapiens	19-22
9685591-9	1998	These results indicate that corticosterone in the blood may regulate the circadian rhythm through AVP variation in the SCN.	Corticosterone	28-42	arginine vasopressin	Homo sapiens	98-101
9548700-4	1998	Rats with constant corticosterone levels displayed enhanced footshock-induced Fos expression in the parvicellular compartment of the PVH, as well as in certain limbic and somatosensory cell groups, the locus coeruleus, but not in medullary catecholaminergic cell groups.	Corticosterone	19-33	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	78-81
9663647-9	1998	However, morphine did not significantly affect the weight of the liver, or the plasma CBG binding capacity for corticosterone, in rat pups.	Corticosterone	111-125	serpin family A member 6	Rattus norvegicus	86-89
9663649-13	1998	The ability of other cytokines such as TNF-alpha and IL-6 to release ACTH and corticosterone was significantly (P&lt;0.01) augmented by blockade of NO formation in a manner similar to that found with IL-1beta.	Corticosterone	78-92	tumor necrosis factor	Rattus norvegicus	39-48
9663649-13	1998	The ability of other cytokines such as TNF-alpha and IL-6 to release ACTH and corticosterone was significantly (P&lt;0.01) augmented by blockade of NO formation in a manner similar to that found with IL-1beta.	Corticosterone	78-92	interleukin 6	Rattus norvegicus	53-57
9619376-3	1998	However, there is one previous study which reported that such an inhibitory action of indomethacin on ACTH secretion is mediated principally by a fast, rate-sensitive negative feedback effect of corticosterone which increases after indomethacin injection, rather than by a decrease in PG production.	Corticosterone	195-209	proopiomelanocortin	Homo sapiens	102-106
9660080-1	1998	Vasoactive intestinal peptide (VIP) concentration-dependently enhanced corticosterone and cyclic-AMP release by dispersed rat inner adrenocortical cells.	Corticosterone	71-85	vasoactive intestinal peptide	Rattus norvegicus	31-34
9663650-4	1998	CRH-R mRNA decreased by 59% 5 h after injection of corticosterone (10 mg s.c.) and returned to basal levels by 18 h, a time when plasma corticosterone concentrations were still elevated, and CRH binding and POMC hnRNA were significantly reduced.	Corticosterone	51-65	corticotropin releasing hormone	Rattus norvegicus	0-3
9663650-4	1998	CRH-R mRNA decreased by 59% 5 h after injection of corticosterone (10 mg s.c.) and returned to basal levels by 18 h, a time when plasma corticosterone concentrations were still elevated, and CRH binding and POMC hnRNA were significantly reduced.	Corticosterone	136-150	corticotropin releasing hormone	Rattus norvegicus	0-3
9663650-7	1998	Supporting this hypothesis, simultaneous injection of corticosterone and CRH restored CRH-R mRNA expression by 4 h, and increased CRH binding 4 h and 6 h after injection.	Corticosterone	54-68	corticotropin releasing hormone	Rattus norvegicus	86-89
9663650-7	1998	Supporting this hypothesis, simultaneous injection of corticosterone and CRH restored CRH-R mRNA expression by 4 h, and increased CRH binding 4 h and 6 h after injection.	Corticosterone	54-68	corticotropin releasing hormone	Rattus norvegicus	86-89
9566508-1	1998	Recently, we reported that intrahippocampal cholinergic blockade increased corticosterone (CORT) and adrenocorticotrophin (ACTH) secretion induced by restraint stress.	Corticosterone	75-89	cortistatin	Rattus norvegicus	91-95
9528929-2	1998	It has also been proposed that placental 11beta-HSD expression may influence local glucocorticoid actions by regulating access of corticosterone to the glucocorticoid receptor (GR) or mineralocorticoid receptor (MR).	Corticosterone	130-144	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	152-175
9605579-18	1998	The data are consistent with the proposal that chronic m-CPP induced some down-regulation of hypothalamic 5-HT2C receptors which contribute, in a tonic manner, to plasma corticosterone secretion under the conditions investigated.	Corticosterone	170-184	5-hydroxytryptamine receptor 2C	Rattus norvegicus	106-112
9624593-13	1998	Plasma corticosterone levels in the "dehydrated + aCSF" group were significantly higher (p &lt; 0.05) than in each of the other groups ("dehydrated + hANP", "euhydrated + aCSF", "euhydrated + hANP").	Corticosterone	7-21	natriuretic peptide A	Homo sapiens	192-197
9528929-2	1998	It has also been proposed that placental 11beta-HSD expression may influence local glucocorticoid actions by regulating access of corticosterone to the glucocorticoid receptor (GR) or mineralocorticoid receptor (MR).	Corticosterone	130-144	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	177-179
9528930-12	1998	Leptin also was found to affect plasma levels of corticosterone.	Corticosterone	49-63	leptin	Mus musculus	0-6
9550546-8	1998	In contrast, when differentiation was induced by a hormonal cocktail (MIX), including insulin and corticosterone, NDGA decreased GPDH activity (MIX, 329 +/- 66; MIX + NDGA, 142 +/- 40; P &lt; .03).	Corticosterone	98-112	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	129-133
9483552-6	1998	Fos immunoreactivity was marked in parvocellular regions of the paraventricular nucleus of the hypothalamus following both restraint periods and at both ages, an observation consistent with previous observations that restraint increases plasma corticosterone at both ages.	Corticosterone	244-258	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
9501200-8	1998	Similar subnuclear distribution was observed with corticosterone, another MR agonist.	Corticosterone	50-64	nuclear receptor subfamily 3 group C member 2	Homo sapiens	74-76
9502816-3	1998	11beta-HSD type 1 (11beta-HSD1) is a bidirectional enzyme in vitro that acts predominantly as a reductase (regenerating corticosterone) in intact neurons.	Corticosterone	120-134	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	0-30
9502826-2	1998	To identify molecular mechanisms at the single-cell level, we characterized mRNA expression corresponding to voltage- and ligand-gated Ca channels in individual dissociated CA1 neurons in response to long-term corticosterone (CORT) exposure.	Corticosterone	210-224	carbonic anhydrase 1	Homo sapiens	173-176
9502826-2	1998	To identify molecular mechanisms at the single-cell level, we characterized mRNA expression corresponding to voltage- and ligand-gated Ca channels in individual dissociated CA1 neurons in response to long-term corticosterone (CORT) exposure.	Corticosterone	210-224	cortistatin	Homo sapiens	226-230
9554991-10	1998	ApoE-deficient mice showed a weaker corticosterone response to the initial restraint stress and a slower descending rate in serum corticosterone level during a 30-min post-stress period than their wild-type controls.	Corticosterone	36-50	apolipoprotein E	Mus musculus	0-4
9554991-10	1998	ApoE-deficient mice showed a weaker corticosterone response to the initial restraint stress and a slower descending rate in serum corticosterone level during a 30-min post-stress period than their wild-type controls.	Corticosterone	130-144	apolipoprotein E	Mus musculus	0-4
9554991-11	1998	However, higher baseline levels and stronger corticosterone responses were observed in ApoE-deficient mice than in wild-type mice when exposed to repeated restraint stress.	Corticosterone	45-59	apolipoprotein E	Mus musculus	87-91
9685211-11	1998	In contrast, these drugs appear to suppress a corticosterone-mediated transcriptional response by a different mechanism, perhaps one involving their binding to glucocorticoid receptor-associated immunophilins.	Corticosterone	46-60	nuclear receptor subfamily 3 group C member 1	Homo sapiens	160-183
9482808-11	1998	IS produced large increases in brain IL-1beta protein in the adrenalectomized subjects 2 hr after stress, whether basal corticosterone levels had been maintained.	Corticosterone	120-134	interleukin 1 beta	Rattus norvegicus	37-45
9482808-12	1998	Thus elimination of the stress-induced rise in corticosterone unmasked a robust and widespread increase in brain IL-1beta.	Corticosterone	47-61	interleukin 1 beta	Rattus norvegicus	113-121
9587916-3	1998	Using D-[2,3-3H]aspartic acid ([3H]D-Asp) as a tracer, it was found that corticosterone (CORT, the physiological GC in rat) enhanced the overflow of extracellular [3H]D-Asp in astrocyte cultures and, to a lesser extent, in neuron-enriched cultures during cyanide-induced ischemia.	Corticosterone	73-87	cortistatin	Rattus norvegicus	89-93
9593598-4	1998	Neuropeptide Y (10(-9) and 10(-7) M), following intracerebroventricular infusion, also decreased the neutrophil response, but significantly raised the corticosterone concentration.	Corticosterone	151-165	neuropeptide Y	Homo sapiens	0-14
9554945-0	1998	Conditioned release of corticosterone by contextual stimuli associated with cocaine is mediated by corticotropin-releasing factor.	Corticosterone	23-37	corticotropin releasing hormone	Rattus norvegicus	99-129
9486972-7	1998	The rise in leptin preceded the establishment of adult levels of corticosterone, thyroxine, and estradiol.	Corticosterone	65-79	leptin	Mus musculus	12-18
9486972-10	1998	When ad libitum feeding was restricted to the light cycle, peak corticosterone levels were shifted to the beginning of the light cycle and coincided with the nadir of leptin.	Corticosterone	64-78	leptin	Mus musculus	167-173
9605554-12	1998	These results imply that the melanocortin-4-receptor, and not the melanocortin-3-receptor, is involved in the ACTH1-24-induced rise in plasma levels of ACTH and corticosterone, and excessive grooming.	Corticosterone	161-175	melanocortin 4 receptor	Homo sapiens	29-52
9753154-10	1998	Moreover, both doses of IL-2 caused a dose-dependent increase in body temperature and free corticosterone levels.	Corticosterone	91-105	interleukin 2	Rattus norvegicus	24-28
9753154-12	1998	However, IL-1 seemed to play only a minor role in the IL-2-induced increase in free corticosterone.	Corticosterone	84-98	interleukin 2	Rattus norvegicus	54-58
9640253-9	1998	These results suggest that the increase in basal corticosterone concentrations in old mice induces the generation of Fc gamma RII/IIIbright suppressor cells, possibly leading to the immune-suppressive state.	Corticosterone	49-63	Fc receptor, IgG, low affinity IIb	Mus musculus	117-129
9618026-1	1998	11Beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD-1) catalyses the reversible metabolism of physiological glucocorticoids (cortisol, corticosterone) to inactive metabolites (cortisone, 11-dehydrocorticosterone), thus regulating glucocorticoid access to receptors.	Corticosterone	138-152	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	44-56
9553757-12	1998	Administration of corticosterone to ovariectomized rats as well as ovariectomy + adrenalectomy significantly increased the activity of cathepsin-D and cathepsin-E.	Corticosterone	18-32	cathepsin D	Rattus norvegicus	135-146
9478930-4	1998	Using the quantitative reverse transcriptase-polymerase chain reaction, the terminal enzymes of corticosterone and aldosterone synthesis (11beta-hydroxylase and aldosterone synthase, respectively) were detected in the rat heart.	Corticosterone	96-110	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	161-181
9478930-6	1998	Perfusion of angiotensin II or adrenocorticotropin for 3 h increased aldosterone and corticosterone production and decreased deoxycorticosterone, suggesting that aldosterone and corticosterone are formed within the isolated heart from a locally present substrate.	Corticosterone	85-99	angiotensinogen	Rattus norvegicus	13-27
9478930-6	1998	Perfusion of angiotensin II or adrenocorticotropin for 3 h increased aldosterone and corticosterone production and decreased deoxycorticosterone, suggesting that aldosterone and corticosterone are formed within the isolated heart from a locally present substrate.	Corticosterone	130-144	angiotensinogen	Rattus norvegicus	13-27
9486972-11	1998	The inverse relationship between leptin and corticosterone was maintained such that a rise in leptin after feeding was associated with a decline in corticosterone.	Corticosterone	44-58	leptin	Mus musculus	33-39
9486972-11	1998	The inverse relationship between leptin and corticosterone was maintained such that a rise in leptin after feeding was associated with a decline in corticosterone.	Corticosterone	44-58	leptin	Mus musculus	94-100
9486972-11	1998	The inverse relationship between leptin and corticosterone was maintained such that a rise in leptin after feeding was associated with a decline in corticosterone.	Corticosterone	148-162	leptin	Mus musculus	33-39
9486972-11	1998	The inverse relationship between leptin and corticosterone was maintained such that a rise in leptin after feeding was associated with a decline in corticosterone.	Corticosterone	148-162	leptin	Mus musculus	94-100
9486972-15	1998	Therefore, it is likely that factors in addition to leptin are involved in the regulation of the circadian rhythm of corticosterone.	Corticosterone	117-131	leptin	Mus musculus	52-58
9541747-3	1998	In adults, both neonatal (neoGDX) and adult gonadectomy (adult GDX) resulted in elevated corticosterone (CORT) levels in response to stress compared to intact rats.	Corticosterone	89-103	cortistatin	Rattus norvegicus	105-109
9486310-3	1998	A marked dose-dependent increase in plasma corticosterone was detected from 20 min to 2 h after intracerebroventricular administration of aFGF (1-10 ng).	Corticosterone	43-57	fibroblast growth factor 1	Rattus norvegicus	138-142
9486310-5	1998	Significant dose-dependent increases in plasma corticosterone were also observed after intravenous injections of aFGF (1, 10, and 100 ng), together with increases in the plasma ACTH level.	Corticosterone	47-61	fibroblast growth factor 1	Rattus norvegicus	113-117
9486310-6	1998	Pretreatment with antibody to corticotropin-releasing factor via the intracerebroventricular route abolished the increases in corticosterone induced by intracerebroventricularly administered aFGF, but not those induced by intravenous injection of aFGF.	Corticosterone	126-140	corticotropin releasing hormone	Rattus norvegicus	30-60
9486310-6	1998	Pretreatment with antibody to corticotropin-releasing factor via the intracerebroventricular route abolished the increases in corticosterone induced by intracerebroventricularly administered aFGF, but not those induced by intravenous injection of aFGF.	Corticosterone	126-140	fibroblast growth factor 1	Rattus norvegicus	191-195
9486310-7	1998	In adrenal glands perfused in situ with artificial medium, the corticosterone secretion rate increased slightly in response to 10(-9) M aFGF.	Corticosterone	63-77	fibroblast growth factor 1	Rattus norvegicus	136-140
9666350-5	1998	The reduction was corrected by hormonal replacement with corticosterone pellets, showing that normal levels of circulating corticosteroids are required to maintain leptin expression and secretion in the body.	Corticosterone	57-71	leptin	Rattus norvegicus	164-170
9553757-12	1998	Administration of corticosterone to ovariectomized rats as well as ovariectomy + adrenalectomy significantly increased the activity of cathepsin-D and cathepsin-E.	Corticosterone	18-32	cathepsin E	Rattus norvegicus	151-162
9553757-13	1998	Adrenalectomy significantly decreased the activity of cathepsin-D, while administration of corticosterone increased the cathepsin-D and cathepsin-E in the uterus.	Corticosterone	91-105	cathepsin D	Rattus norvegicus	120-131
9553757-13	1998	Adrenalectomy significantly decreased the activity of cathepsin-D, while administration of corticosterone increased the cathepsin-D and cathepsin-E in the uterus.	Corticosterone	91-105	cathepsin E	Rattus norvegicus	136-147
9526846-2	1998	Experiments were conducted to investigate whether maternal manipulation with saline or with GCs alters the corticosterone (CORT) response to a mild stressor in the offspring, and whether maternal manipulation results in long-term altered in vivo humoral and cellular immune responsiveness in the offspring.	Corticosterone	107-121	cortistatin	Rattus norvegicus	123-127
9498232-0	1998	Interleukin-1 receptor antagonist inhibits transient increase of plasma corticosterone in the initial phase of trimethyltin-induced hippocampal necrosis.	Corticosterone	72-86	interleukin 1 receptor antagonist	Rattus norvegicus	0-33
9498232-1	1998	The temporal increase of plasma corticosterone (CORT) levels at 3 or 4 days after a single oral administration of trimethyltin (TMT) was suppressed by intracerebroventricular administration of the interleukin-1 receptor antagonist (IL-1ra).	Corticosterone	32-46	cortistatin	Rattus norvegicus	48-52
9498232-1	1998	The temporal increase of plasma corticosterone (CORT) levels at 3 or 4 days after a single oral administration of trimethyltin (TMT) was suppressed by intracerebroventricular administration of the interleukin-1 receptor antagonist (IL-1ra).	Corticosterone	32-46	interleukin 1 receptor antagonist	Rattus norvegicus	197-230
9498232-1	1998	The temporal increase of plasma corticosterone (CORT) levels at 3 or 4 days after a single oral administration of trimethyltin (TMT) was suppressed by intracerebroventricular administration of the interleukin-1 receptor antagonist (IL-1ra).	Corticosterone	32-46	interleukin 1 receptor antagonist	Rattus norvegicus	232-238
9516715-2	1998	This IPG is also able to inhibit the stimulation by ACTH of the production of the main glucocorticoid, corticosterone and the main mineralocorticoid, aldosterone, in rat adrenocortical cells.	Corticosterone	103-117	proopiomelanocortin	Homo sapiens	52-56
9500960-1	1998	Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields.	Corticosterone	29-43	carbonic anhydrase 1	Homo sapiens	112-115
9500960-1	1998	Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields.	Corticosterone	29-43	carbonic anhydrase 2	Homo sapiens	116-119
9500960-3	1998	In addition, chronic pretreatment with corticosterone aggravates ischemia-induced neuronal damage in the CA3-CA4 subfields.	Corticosterone	39-53	carbonic anhydrase 3	Homo sapiens	105-112
9500960-6	1998	We assume that the increase of calbindin-D28k expression in the CA1-CA2 subfields in corticosterone-treated animals is an adaptive response to the exogenous stress.	Corticosterone	85-99	carbonic anhydrase 1	Homo sapiens	64-67
9500960-6	1998	We assume that the increase of calbindin-D28k expression in the CA1-CA2 subfields in corticosterone-treated animals is an adaptive response to the exogenous stress.	Corticosterone	85-99	carbonic anhydrase 2	Homo sapiens	68-71
9500960-8	1998	This finding, supports: (1) the hypothesis that corticosterone treatment, when paired with an ischemic insult, causes a prolonged elevation of neuronal [Ca2+]i, in an energy dependent manner, probably through the reduction of calcium efflux and (2) that neurons which do contain calbindin-D28k are particularly predisposed to ischemic insults.	Corticosterone	48-62	carbonic anhydrase 2	Homo sapiens	153-156
9516715-7	1998	These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol.	Corticosterone	300-314	proopiomelanocortin	Homo sapiens	24-28
9516715-7	1998	These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol.	Corticosterone	300-314	glucose-6-phosphate isomerase	Rattus norvegicus	41-48
9516715-7	1998	These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol.	Corticosterone	300-314	glucose-6-phosphate isomerase	Bos taurus	41-44
9516715-7	1998	These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol.	Corticosterone	300-314	proopiomelanocortin	Homo sapiens	187-191
9516715-7	1998	These data suggest that ACTH activates a GPI-PLC in rat adrenal cortex, which is in agreement with our previous data in calf adrenocortical cells; thus, the hydrolysis of GPI provoked by ACTH takes place in different mammals and the IPG released could inhibit ACTH-mediated synthesis of aldosterone, corticosterone and cortisol.	Corticosterone	300-314	proopiomelanocortin	Homo sapiens	187-191
9548381-0	1998	The antidepressant, nefazodone, attenuates corticosterone-induced increases in 5-HT2A receptor-mediated behaviors in the female rat.	Corticosterone	43-57	5-hydroxytryptamine receptor 2A	Canis lupus familiaris	79-94
9548381-6	1998	This suggests that corticosterone influences sexual behavior and wet dog shakes via a 5-HT2A receptor mechanism.	Corticosterone	19-33	5-hydroxytryptamine receptor 2A	Canis lupus familiaris	86-101
9453158-2	1998	We demonstrate that Cdr1p can specifically transport human steroid hormones namely beta-estradiol and corticosterone.	Corticosterone	102-116	cerebellar degeneration related protein 1	Homo sapiens	20-25
9453158-3	1998	Saccharomyces cerevisiae transformant S-12, harbouring the CDR1 gene, accumulated about 3-fold less [3H] beta-estradiol and about 2-fold less [3H]corticosterone than the non-transformed strain.	Corticosterone	146-160	cerebellar degeneration related protein 1	Homo sapiens	59-63
9496245-1	1998	Two isozymes of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) are responsible for the interconversion of the active glucocorticoid, cortisol in man, (corticosterone in the rodent), to the inactive 11-keto metabolite, cortisone (11-dehydrocorticosterone).	Corticosterone	166-180	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	27-34
9869331-5	1998	In all the above, many hippocampal neurons were severely damaged, however, CA3 pyramidal cells were mostly affected in normal aging and following hypobaric hypoxia, whereas CA1 cells were especially affected following corticosterone administration, global ischemia and ChE inhibition.	Corticosterone	218-232	carbonic anhydrase 1	Rattus norvegicus	173-176
9486840-1	1998	The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk.	Corticosterone	253-267	arginine vasopressin	Rattus norvegicus	39-50
9486840-1	1998	The authors have shown previously that vasopressin (VP) release from suprachiasmatic nucleus (SCN) efferents in rats is important for the timing of the circadian activity of the hypothalamo-pituitary-adrenal (HPA) axis, resulting in a circadian rise in corticosterone at dusk.	Corticosterone	253-267	arginine vasopressin	Rattus norvegicus	52-54
9486840-5	1998	Despite these previous results, the authors investigated a putative involvement of SCN-derived VP in the control of the prefeeding corticosterone peak by measuring the intranuclear release of VP in the SCN and plasma corticosterone levels in rats in ad libitum feeding conditions as well as in animals that were obliged to feed during a 2-h period in the middle of the light period.	Corticosterone	131-145	arginine vasopressin	Rattus norvegicus	95-97
9489508-1	1998	The effect of SM12502 and CV6209, platelet-activating factor (PAF) receptor antagonists on corticosterone (B) secretion induced by ACTH was examined in the perfused adrenals of CD1 ICR (normal) and CD1 ICR nu/nu (athymic) mice.	Corticosterone	91-105	pro-opiomelanocortin-alpha	Mus musculus	131-135
9570336-1	1998	Pancreatic polypeptide (PP) concentration-dependently raised basal corticosterone and cyclic-AMP production of dispersed rat zona fasciculata/reticularis adrenocortical cells, maximal effective concentration being 10(-7) M. 10(-7) M PP also significantly enhanced submaximally (10[-12]/10[-11] M), but not maximally (10[-9]/10[-8] M) ACTH-stimulated corticosterone and cyclic-AMP release.	Corticosterone	67-81	pancreatic polypeptide	Rattus norvegicus	0-27
9570336-1	1998	Pancreatic polypeptide (PP) concentration-dependently raised basal corticosterone and cyclic-AMP production of dispersed rat zona fasciculata/reticularis adrenocortical cells, maximal effective concentration being 10(-7) M. 10(-7) M PP also significantly enhanced submaximally (10[-12]/10[-11] M), but not maximally (10[-9]/10[-8] M) ACTH-stimulated corticosterone and cyclic-AMP release.	Corticosterone	67-81	pancreatic polypeptide	Rattus norvegicus	24-26
9570336-1	1998	Pancreatic polypeptide (PP) concentration-dependently raised basal corticosterone and cyclic-AMP production of dispersed rat zona fasciculata/reticularis adrenocortical cells, maximal effective concentration being 10(-7) M. 10(-7) M PP also significantly enhanced submaximally (10[-12]/10[-11] M), but not maximally (10[-9]/10[-8] M) ACTH-stimulated corticosterone and cyclic-AMP release.	Corticosterone	350-364	pancreatic polypeptide	Rattus norvegicus	0-27
9570336-1	1998	Pancreatic polypeptide (PP) concentration-dependently raised basal corticosterone and cyclic-AMP production of dispersed rat zona fasciculata/reticularis adrenocortical cells, maximal effective concentration being 10(-7) M. 10(-7) M PP also significantly enhanced submaximally (10[-12]/10[-11] M), but not maximally (10[-9]/10[-8] M) ACTH-stimulated corticosterone and cyclic-AMP release.	Corticosterone	350-364	pancreatic polypeptide	Rattus norvegicus	24-26
9570336-2	1998	Corticosterone responses to PP were abolished by the specific protein kinase A (PKA) antagonist H-89 (10[-5] M).	Corticosterone	0-14	pancreatic polypeptide	Rattus norvegicus	28-30
9570336-2	1998	Corticosterone responses to PP were abolished by the specific protein kinase A (PKA) antagonist H-89 (10[-5] M).	Corticosterone	0-14	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	62-78
9570336-2	1998	Corticosterone responses to PP were abolished by the specific protein kinase A (PKA) antagonist H-89 (10[-5] M).	Corticosterone	0-14	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	80-83
9585109-1	1998	The effects of the bacterial endotoxin lipopolysaccharide (LPS) and interleukin (IL)-1beta on corticosterone secretion has been studied in vivo by employing the technique of in situ perfusion of the isolated rat left adrenal gland.	Corticosterone	94-108	interleukin 1 beta	Rattus norvegicus	68-90
9585109-2	1998	Both LPS and IL-1beta dose-dependently raised corticosterone output, the response peaking at 60 and 90 min, respectively.	Corticosterone	46-60	interleukin 1 beta	Rattus norvegicus	13-21
9453158-5	1998	Efflux of beta-estradiol and corticosterone was inhibited by a 100-fold higher (200 nM) concentration of beta-estradiol, corticosterone, ergosterol or dexamethasone, but progesterone which could not be transported by Cdr1p did not affect the efflux and thus accumulation.	Corticosterone	29-43	cerebellar degeneration related protein 1	Homo sapiens	217-222
9453158-5	1998	Efflux of beta-estradiol and corticosterone was inhibited by a 100-fold higher (200 nM) concentration of beta-estradiol, corticosterone, ergosterol or dexamethasone, but progesterone which could not be transported by Cdr1p did not affect the efflux and thus accumulation.	Corticosterone	121-135	cerebellar degeneration related protein 1	Homo sapiens	217-222
9453158-8	1998	In conclusion, we show that human steroid hormones could be the substrates for Cdr1p and the energy dependent transport mediated by it is specific for estradiol and corticosterone.	Corticosterone	165-179	cerebellar degeneration related protein 1	Homo sapiens	79-84
9435639-0	1997	Role of circulating endotoxin and interleukin-6 in the ACTH and corticosterone response to intraperitoneal LPS.	Corticosterone	64-78	interleukin 6	Rattus norvegicus	34-47
9806212-4	1998	Aldosterone and corticosterone levels were lower in AT1a deficient mice.	Corticosterone	16-30	angiotensin II receptor, type 1a	Mus musculus	52-56
9806212-7	1998	Ang II increased corticosterone levels in wild-type mice but not in AT1a deficient mice.	Corticosterone	17-31	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
27406204-0	1998	Prolonged Stimulation of Corticosterone Secretion by Corticotropin-Releasing Hormone in Rats Exhibiting High Preference for Dietary Fat.	Corticosterone	25-39	corticotropin releasing hormone	Rattus norvegicus	53-84
27406204-0	1998	Prolonged Stimulation of Corticosterone Secretion by Corticotropin-Releasing Hormone in Rats Exhibiting High Preference for Dietary Fat.	Corticosterone	25-39	FAT atypical cadherin 1	Rattus norvegicus	132-135
27406204-1	1998	Through the secretion of corticosterone, the hypothalamo-pituitary-adrenal (HPA) axis is thought to play an important role in the regulation of caloric intake and dietary fat preference.	Corticosterone	25-39	FAT atypical cadherin 1	Rattus norvegicus	171-174
27406204-2	1998	In an earlier study, we demonstrated a positive correlation between urinary corticosterone output and dietary fat preference.	Corticosterone	76-90	FAT atypical cadherin 1	Rattus norvegicus	110-113
27406204-5	1998	The results of these studies show a delayed and blunted but more prolonged corticosterone response to CRH in the fat-preferring rats compared with that of the carbohydrate-preferring rats.	Corticosterone	75-89	corticotropin releasing hormone	Rattus norvegicus	102-105
27406204-5	1998	The results of these studies show a delayed and blunted but more prolonged corticosterone response to CRH in the fat-preferring rats compared with that of the carbohydrate-preferring rats.	Corticosterone	75-89	FAT atypical cadherin 1	Rattus norvegicus	113-116
27405913-2	1998	In the present studies, we determined changes in circulating leptin concentrations by modulating sympathetic activity by adrenalectomy, corticosterone supplement, hypothalamic CRH infusion and starvation in male Wistar rats.	Corticosterone	136-150	leptin	Rattus norvegicus	61-67
27405913-3	1998	Bilateral adrenalectomy significantly inhibited serum leptin concentrations and the continuous supplement of corticosterone by silastic tube restored the reduction of serum leptin concentrations in adrenalectomized rats.	Corticosterone	109-123	leptin	Rattus norvegicus	173-179
9423970-3	1998	Serum samples were taken immediately after exercise and corticosterone (CORT) concentration was determined by radioimmunoassay.	Corticosterone	56-70	cortistatin	Mus musculus	72-76
10074800-3	1998	By direct and indirect connections VP serves to inhibit corticosterone secretion, not only by affecting ACTH secretion but also by controlling the adrenal cortex via a neuronal route.	Corticosterone	56-70	arginine vasopressin	Homo sapiens	35-37
9391003-4	1997	GFAP-IL6 mice heterozygous or homozygous for the IL-6 transgene had normal basal plasma corticosterone levels but, after restraint stress, showed abnormally increased levels in a gene dose-dependent manner.	Corticosterone	88-102	glial fibrillary acidic protein	Mus musculus	0-4
9391003-4	1997	GFAP-IL6 mice heterozygous or homozygous for the IL-6 transgene had normal basal plasma corticosterone levels but, after restraint stress, showed abnormally increased levels in a gene dose-dependent manner.	Corticosterone	88-102	interleukin 6	Mus musculus	5-8
9391003-4	1997	GFAP-IL6 mice heterozygous or homozygous for the IL-6 transgene had normal basal plasma corticosterone levels but, after restraint stress, showed abnormally increased levels in a gene dose-dependent manner.	Corticosterone	88-102	interleukin 6	Mus musculus	49-53
9391003-5	1997	The increased plasma corticosterone levels in the IL-6 transgenic mice were associated with increased adrenal corticosterone content and hyperplasia of both adrenal cortex and medulla.	Corticosterone	21-35	interleukin 6	Mus musculus	50-54
9391003-5	1997	The increased plasma corticosterone levels in the IL-6 transgenic mice were associated with increased adrenal corticosterone content and hyperplasia of both adrenal cortex and medulla.	Corticosterone	110-124	interleukin 6	Mus musculus	50-54
9391003-8	1997	A similar mechanism may play a role in the blunted ACTH response and elevated corticosterone levels under pathophysiological conditions observed in humans with high brain levels of IL-6.	Corticosterone	78-92	interleukin 6	Homo sapiens	181-185
9444626-0	1997	Role of nitric oxide in the vasopressin-induced corticosterone secretion in rats.	Corticosterone	48-62	arginine vasopressin	Rattus norvegicus	28-39
9787259-0	1997	Correlation between Changes in Stress-Induced Corticosterone Secretion and GR mRNA Levels.	Corticosterone	46-60	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	75-77
9787259-8	1997	However, an individual"s GR mRNA levels measured within the CA1/2 region of the hippocampus and the mpPVN were significantly correlated with the degree of habituation of the corticosterone response to stress measured on Day 5.	Corticosterone	174-188	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	25-27
9348353-5	1997	The influence of the initial drug treatment was not mimicked by exposure to foot shocks, nor was it prevented by administering a potent corticotropin-releasing factor antagonist to block the elevations in plasma ACTH and corticosterone induced by this initial treatment.	Corticosterone	221-235	corticotropin releasing hormone	Rattus norvegicus	136-166
9462893-14	1997	Nifedipine was found to suppress both Ang II-induced corticosterone release and c-fos expression in the following areas: organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MNPO), hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON).	Corticosterone	53-67	angiotensinogen	Rattus norvegicus	38-44
9372553-1	1997	Previous in vitro studies showed that glucocorticoid receptor activation (notably by corticosterone) could induce a functional desensitization of somatodendritic 5-HT1A autoreceptors in the dorsal raphe nucleus [Laaris et al.	Corticosterone	85-99	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	38-61
9372553-1	1997	Previous in vitro studies showed that glucocorticoid receptor activation (notably by corticosterone) could induce a functional desensitization of somatodendritic 5-HT1A autoreceptors in the dorsal raphe nucleus [Laaris et al.	Corticosterone	85-99	5-hydroxytryptamine receptor 1A	Rattus norvegicus	162-168
9444626-2	1997	We investigated the involvement of NO in the corticosterone secretion induced by vasopressin (AVP), a potent coregulator of the HPA activity.	Corticosterone	45-59	arginine vasopressin	Rattus norvegicus	81-92
9356047-5	1997	I3vt leptin caused an increase in plasma corticosterone and plasma leptin levels relative to the control condition.	Corticosterone	41-55	leptin	Homo sapiens	5-11
9426159-0	1997	11 beta-hydroxysteroid dehydrogenase-2 is a high affinity corticosterone-binding protein.	Corticosterone	58-72	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	0-7
9426159-3	1997	Based on similarities in steroid specificity and kinetic parameters, we hypothesized that these corticosterone binding sites belong to the type 2 isoform of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD2).	Corticosterone	96-110	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	157-164
9426159-3	1997	Based on similarities in steroid specificity and kinetic parameters, we hypothesized that these corticosterone binding sites belong to the type 2 isoform of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD2).	Corticosterone	96-110	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	195-207
9426159-4	1997	The goal of this study was to express the recombinant rabbit 11 beta-HSD2 in mammalian cells and test if such cells acquire both NAD-dependent 11 beta-HSD2 activity as well as high affinity corticosterone binding sites.	Corticosterone	190-204	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	42-73
9356047-0	1997	Central leptin stimulates corticosterone secretion at the onset of the dark phase.	Corticosterone	26-40	leptin	Homo sapiens	8-14
9389418-4	1997	Neuropeptide Y increased the basal plasma concentrations of adrenocorticotropic hormone and corticosterone during the first 2 days of its intracerebroventricular infusion and increased cold stress-induced plasma adrenocorticotropic hormone concentrations.	Corticosterone	92-106	neuropeptide Y	Rattus norvegicus	0-14
9430823-4	1997	Exogenous ET-1 increased ACTH, corticosterone and aldosterone blood levels in control rats, as well as evoked a sizable enhancement of the HPA axis response to ether stress and a marked depression of the response to cold stress.	Corticosterone	31-45	endothelin 1	Rattus norvegicus	10-14
9355104-4	1997	One hour after GR antagonist injection, significant increases in plasma ACTH and corticosterone levels were observed in the i.c.v.	Corticosterone	81-95	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	15-17
9355104-6	1997	In contrast, a significant decrease in ACTH levels, and a slight, but non-significant decrease in corticosterone concentrations were attained one hour after intrahippocampal injection of the GR antagonist.	Corticosterone	98-112	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	191-193
9355104-7	1997	Injection of the MR antagonist, on the other hand, resulted in enhanced ACTH and corticosterone levels irrespective of the site of injection.	Corticosterone	81-95	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	17-19
9436645-5	1997	We further show that prior exposure to IMO stress for 6 days, or implantation of corticosterone pellets suppresses the induction of c-fos, fos B, jun B and NGFI-B, but not that of NGFI-A in the rat PVH.	Corticosterone	81-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-137
9436645-5	1997	We further show that prior exposure to IMO stress for 6 days, or implantation of corticosterone pellets suppresses the induction of c-fos, fos B, jun B and NGFI-B, but not that of NGFI-A in the rat PVH.	Corticosterone	81-95	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	139-144
9436645-5	1997	We further show that prior exposure to IMO stress for 6 days, or implantation of corticosterone pellets suppresses the induction of c-fos, fos B, jun B and NGFI-B, but not that of NGFI-A in the rat PVH.	Corticosterone	81-95	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	146-151
9436645-5	1997	We further show that prior exposure to IMO stress for 6 days, or implantation of corticosterone pellets suppresses the induction of c-fos, fos B, jun B and NGFI-B, but not that of NGFI-A in the rat PVH.	Corticosterone	81-95	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	156-162
9652969-0	1997	Evidence that elevated plasma corticosterone levels are the cause of reduced hypothalamic corticotrophin-releasing hormone gene expression in diabetes.	Corticosterone	30-44	corticotropin releasing hormone	Rattus norvegicus	90-122
9652969-6	1997	In contrast, CRH mRNA levels measured in the PVN by in situ hybridization were inversely related to the plasma corticosterone level (r = -0.68; P = 0.045).	Corticosterone	111-125	corticotropin releasing hormone	Rattus norvegicus	13-16
9652969-9	1997	Corticosterone administration lowered CRH mRNA comparably in both diabetic and nondiabetic ADX rats.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	38-41
9356047-6	1997	The effects of i3vt leptin on corticosterone secretion became particularly apparent after the onset of the dark phase.	Corticosterone	30-44	leptin	Homo sapiens	20-26
9380279-7	1997	The discrepancy between ACTH and corresponding corticosterone secretions in transgenic mice could be attributed, in part, to a reduced sensitivity of the adrenal gland to stimulation by ACTH.	Corticosterone	47-61	pro-opiomelanocortin-alpha	Mus musculus	186-190
9357768-5	1997	EGF not only prevented but also reversed ANG II receptor upregulation by 100 nM corticosterone.	Corticosterone	80-94	epidermal growth factor	Homo sapiens	0-3
9357768-5	1997	EGF not only prevented but also reversed ANG II receptor upregulation by 100 nM corticosterone.	Corticosterone	80-94	angiotensinogen	Homo sapiens	41-47
9426159-9	1997	The steroid specificity of the binding sites, as determined by competing [3H]corticosterone with unlabeled steroids, is identical to that of 11 beta-HSD2: corticosterone &gt;&gt; 11-hydroxyprogesterone &gt; carbenoxolone &gt; 11 dehydrocorticosterone &gt; cortisol &gt; progesterone approximately DOC &gt;&gt;&gt; DEX &gt; RU 28362 - aldosterone.	Corticosterone	155-169	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	141-153
9426159-10	1997	These results strongly suggest that the previously described high affinity corticosterone binding sites are 11 beta-HSD2.	Corticosterone	75-89	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	108-120
9322962-5	1997	In conscious, freely moving, and unstressed rats, central injection of GLP-1 significantly elevated plasma levels of vasopressin 15 and 30 min after administration (basal, 0.8 +/- 0.2 pg/ml; 15 min, 7.5 +/- 2.0 pg/ml; 30 min, 5.6 +/- 1.1 pg/ml; mean +/- SEM) and elevated corticosterone 15 min after administration (52 +/- 13 vs. 447 +/- 108 ng/ml, basal vs. 15 min; mean +/- SEM).	Corticosterone	272-286	glucagon	Rattus norvegicus	71-76
9405958-9	1997	Because corticosterone- and stress-induced atrophy of CA3 dendrites is also blocked by phenytoin, an inhibitor of excitatory amino acid release and actions, these results suggest that serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and that the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus.	Corticosterone	8-22	carbonic anhydrase 3	Homo sapiens	54-57
9405958-9	1997	Because corticosterone- and stress-induced atrophy of CA3 dendrites is also blocked by phenytoin, an inhibitor of excitatory amino acid release and actions, these results suggest that serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and that the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus.	Corticosterone	8-22	carbonic anhydrase 3	Homo sapiens	448-451
9405958-9	1997	Because corticosterone- and stress-induced atrophy of CA3 dendrites is also blocked by phenytoin, an inhibitor of excitatory amino acid release and actions, these results suggest that serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and that the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus.	Corticosterone	216-230	carbonic anhydrase 3	Homo sapiens	54-57
9405958-9	1997	Because corticosterone- and stress-induced atrophy of CA3 dendrites is also blocked by phenytoin, an inhibitor of excitatory amino acid release and actions, these results suggest that serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and that the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus.	Corticosterone	216-230	carbonic anhydrase 3	Homo sapiens	448-451
9405958-9	1997	Because corticosterone- and stress-induced atrophy of CA3 dendrites is also blocked by phenytoin, an inhibitor of excitatory amino acid release and actions, these results suggest that serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and that the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus.	Corticosterone	216-230	carbonic anhydrase 3	Homo sapiens	54-57
9405958-9	1997	Because corticosterone- and stress-induced atrophy of CA3 dendrites is also blocked by phenytoin, an inhibitor of excitatory amino acid release and actions, these results suggest that serotonin released by stress or corticosterone may interact pre- or post-synaptically with glutamate released by stress or corticosterone, and that the final common path may involve interactive effects between serotonin and glutamate receptors on the dendrites of CA3 neurons innervated by mossy fibers from the dentate gyrus.	Corticosterone	216-230	carbonic anhydrase 3	Homo sapiens	448-451
9402220-0	1997	Effect of a long-term nerve growth factor treatment on body weight, blood pressure, and serum corticosterone in rats.	Corticosterone	94-108	nerve growth factor	Rattus norvegicus	22-41
9402220-4	1997	Here we have determined the effects of prolonged peripheral (intraperitoneal) treatment with nerve growth factor on body weight, blood pressure, and serum corticosterone levels in the rat.	Corticosterone	155-169	nerve growth factor	Rattus norvegicus	93-112
9355040-0	1997	Rapid changes of heteronuclear RNA for arginine vasopressin but not for corticotropin releasing hormone in response to acute corticosterone administration.	Corticosterone	125-139	arginine vasopressin	Rattus norvegicus	48-59
9355040-3	1997	After injection of corticosterone in ADX rats there was an extremely rapid reduction in AVP hnRNA which fell markedly within 15 min.	Corticosterone	19-33	arginine vasopressin	Rattus norvegicus	88-91
9355048-1	1997	Administration of neuropeptide Y (NPY) into the hypothalamus or cerebral ventricles has been shown to increase food intake, the secretion of hormones such as insulin, glucagon and corticosterone and to alter the metabolism of carbohydrate and lipids.	Corticosterone	180-194	neuropeptide Y	Rattus norvegicus	18-32
9355048-1	1997	Administration of neuropeptide Y (NPY) into the hypothalamus or cerebral ventricles has been shown to increase food intake, the secretion of hormones such as insulin, glucagon and corticosterone and to alter the metabolism of carbohydrate and lipids.	Corticosterone	180-194	neuropeptide Y	Rattus norvegicus	34-37
9355048-8	1997	In the fed but not fasted state, 3 micrograms ICV NPY increased plasma glucagon and corticosterone levels and attenuated the decline in blood glucose during the ITT.	Corticosterone	84-98	neuropeptide Y	Rattus norvegicus	50-53
9373882-0	1997	Decreased 5-HT1A and increased 5-HT2A receptor binding after chronic corticosterone associated with a behavioural indication of depression but not anxiety.	Corticosterone	69-83	5-hydroxytryptamine receptor 2A	Homo sapiens	31-46
9373882-6	1997	Decreased 5-HT1A receptor binding in the dentate gyrus and increased 5-HT2A receptor binding in the parietal cortex was found following chronic corticosterone treatment.	Corticosterone	144-158	5-hydroxytryptamine receptor 1A	Homo sapiens	10-25
9373882-6	1997	Decreased 5-HT1A receptor binding in the dentate gyrus and increased 5-HT2A receptor binding in the parietal cortex was found following chronic corticosterone treatment.	Corticosterone	144-158	5-hydroxytryptamine receptor 2A	Homo sapiens	69-84
9787255-0	1997	Maintenance of Basal ACTH Levels by Corticosterone and RU28362, but not Aldosterone: Relationship to Available Type I and Type II Corticosteroid Receptor Levels in Brain and Pituitary.	Corticosterone	36-50	proopiomelanocortin	Homo sapiens	21-25
9787255-1	1997	This study examined the ability of three replacement doses of corticosterone, aldosterone, or RU28362 to prevent the increase in morning basal plasma ACTH levels that occurs after adrenalectomy.	Corticosterone	62-76	proopiomelanocortin	Homo sapiens	150-154
9787255-5	1997	The lowest dose of corticosterone partially prevented, and the middle and high doses of corticosterone completely prevented the adrenalectomy-induced increase in ACTH.	Corticosterone	88-102	proopiomelanocortin	Homo sapiens	162-166
9324059-0	1997	Corticosterone is required for the prolactin receptor gene expression in the late pregnant mouse mammary gland.	Corticosterone	0-14	prolactin receptor	Mus musculus	35-53
9324059-6	1997	Corticosterone increased the long form of PRL-R mRNA level when the tissues on day 17 were cultured.	Corticosterone	0-14	prolactin receptor	Mus musculus	42-47
9324059-8	1997	We conclude that corticosterone increases the PRL-R gene expression in the mammary gland before the onset of parturition.	Corticosterone	17-31	prolactin receptor	Mus musculus	46-51
9321900-3	1997	VIP is known to stimulate corticosterone secretion in vitro and to be released from the adrenal medulla following splanchnic nerve stimulation.	Corticosterone	26-40	vasoactive intestinal peptide	Rattus norvegicus	0-3
9275075-3	1997	The hypothalamic-pituitary-adrenal axis (HPAA) is activated in ob/ob mice, and chronic administration of leptin to ob/ob mice decreases plasma corticosterone levels, suggesting that the adipose hormone is capable of inhibiting the HPAA.	Corticosterone	143-157	leptin	Mus musculus	105-111
9475079-0	1997	Effect of dexamethasone and corticosterone on activity levels of ATPase, phosphomonoesterases and phosphodiesterase in liver, muscle and testis of post-hatched White Leghorn chicks.	Corticosterone	28-42	dynein axonemal heavy chain 8	Homo sapiens	65-71
9355039-8	1997	Both ADX and ADX + corticosterone implantation enhanced the NMDA-induced GFAP immunoreactivity.	Corticosterone	19-33	glial fibrillary acidic protein	Rattus norvegicus	73-77
9355039-9	1997	The increase of GFAP immunoreactivity was most pronounced in the adrenalectomized rats supplied with the 100% corticosterone pellets.	Corticosterone	110-124	glial fibrillary acidic protein	Rattus norvegicus	16-20
9316834-3	1997	Since CBG-bound hormone is thought to be physiologically inactive, changes in CBG levels could affect corticosterone action independently of hormone levels per se.	Corticosterone	102-116	serpin family A member 6	Rattus norvegicus	78-81
9316834-11	1997	Furthermore, the increase in CBG resulting from chronic exposure to morphine might contribute to the perpetuation of drug use and to adverse effects of drug exposure by impairing normal functions of corticosterone.	Corticosterone	199-213	serpin family A member 6	Rattus norvegicus	29-32
9449201-2	1997	LH-RH increased basal (but not adrenocorticotropic hormone (ACTH)-stimulated) corticosterone secretion of inner cells, without affecting either aldosterone or corticosterone production by capsular cells.	Corticosterone	78-92	gonadotropin releasing hormone 1	Rattus norvegicus	0-5
9449201-4	1997	The corticosterone secretagogue action of LH-RH was abolished by the protein kinase A inhibitor H-89.	Corticosterone	4-18	gonadotropin releasing hormone 1	Rattus norvegicus	42-47
9449202-1	1997	We have previously shown that calcitonin gene-related peptide (CGRP) stimulates the secretion of corticosterone and aldosterone from the frog adrenal gland in vitro.	Corticosterone	97-111	calcitonin related polypeptide alpha	Homo sapiens	30-61
9449202-1	1997	We have previously shown that calcitonin gene-related peptide (CGRP) stimulates the secretion of corticosterone and aldosterone from the frog adrenal gland in vitro.	Corticosterone	97-111	calcitonin related polypeptide alpha	Homo sapiens	63-67
9449213-3	1997	Recombinant murine leptin was found to increase basal aldosterone and corticosterone production by dispersed rat zona glomerulosa and zona fasciculata-reticularis cells, respectively.	Corticosterone	70-84	leptin	Mus musculus	19-25
9413829-5	1997	The results showed that the enhanced activity of tryptophan 2,3-dioxygenase caused by nicotinic acid was partly restored by adrenaline following adrenalectomy but not by corticosterone supplementation.	Corticosterone	170-184	tryptophan 2,3-dioxygenase	Rattus norvegicus	49-75
9314024-2	1997	Binding of [3H]8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) to 5-HT1A receptors in the hippocampus decreased 24 h after both acute and chronic (14 day) administration of CORT (50 mg/kg, s.c.).	Corticosterone	177-181	5-hydroxytryptamine receptor 1A	Rattus norvegicus	70-76
9277560-5	1997	Of all osmoregulatory hormones tested, only corticosterone (Cort) plasma concentration increased in response to the highest ADM dose from 17.6 +/- 3.1 to 38.9 +/- 6.2 ng/ml, probably due to haroreflex activation.	Corticosterone	44-58	ADM	Oryctolagus cuniculus	124-127
9277389-1	1997	The present study was designed to evaluate the interaction of corticosterone (CORT) and female gonadal steroids on energy balance and lipid metabolism.	Corticosterone	62-76	cortistatin	Rattus norvegicus	78-82
9245486-0	1997	The inhibitory effect of rolipram on TNF-alpha production in mouse blood ex vivo is dependent upon the release of corticosterone and adrenaline.	Corticosterone	114-128	tumor necrosis factor	Mus musculus	37-46
9245486-5	1997	These data suggest the release of both corticosterone and adrenaline contribute to the ability of rolipram to inhibit TNF-alpha production in mouse blood ex vivo.	Corticosterone	39-53	tumor necrosis factor	Mus musculus	118-127
9245533-12	1997	However, with preincubation (4 and 12 hr), T3 inhibited basal and maximal ACTH-induced corticosterone production in a dose-dependent manner.	Corticosterone	87-101	T3	Gallus gallus	43-45
9285241-7	1997	Th1 cytokines, IL-2 and IFN-gamma, were dose-dependently suppressed by corticosterone at physiologic concentrations.	Corticosterone	71-85	interleukin-2	Ovis aries	15-19
9285241-7	1997	Th1 cytokines, IL-2 and IFN-gamma, were dose-dependently suppressed by corticosterone at physiologic concentrations.	Corticosterone	71-85	interferon gamma	Ovis aries	24-33
9277560-5	1997	Of all osmoregulatory hormones tested, only corticosterone (Cort) plasma concentration increased in response to the highest ADM dose from 17.6 +/- 3.1 to 38.9 +/- 6.2 ng/ml, probably due to haroreflex activation.	Corticosterone	60-64	ADM	Oryctolagus cuniculus	124-127
9283048-0	1997	Dopamine-beta-hydroxylase activity is necessary for hypothalamo-pituitary-adrenal (HPA) responses to ether, and stress-induced facilitation of subsequent HPA responses to acute ether emerges as HPA responses are inhibited by increasing corticosterone (B).	Corticosterone	236-250	dopamine beta-hydroxylase	Rattus norvegicus	0-25
9219938-5	1997	Severe histological damage was observed in the CA1 and CA3 cell fields of the hippocampus in corticosterone-treated rats.	Corticosterone	93-107	carbonic anhydrase 1	Rattus norvegicus	47-50
9219938-5	1997	Severe histological damage was observed in the CA1 and CA3 cell fields of the hippocampus in corticosterone-treated rats.	Corticosterone	93-107	carbonic anhydrase 3	Rattus norvegicus	55-58
9219943-7	1997	Interleukin-2-treated animals showed significantly increased plasma levels of corticosterone indicating an hyperfunctioning of the hypothalamic-pituitary-adrenocortical axis that lasted over the 14 day infusion period.	Corticosterone	78-92	interleukin 2	Rattus norvegicus	0-13
9364623-8	1997	Receptor decreases were characterized by a significant decrease in GR binding during the diurnal rise in corticosterone in the spleen and thymus of infected but not uninfected animals on days 5-10 post infection.	Corticosterone	105-119	nuclear receptor subfamily 3 group C member 1	Homo sapiens	67-69
9263204-1	1997	Previous studies in our laboratory suggest that neurotensin (NT) acts centrally to modulate adrenocorticotropin hormone (ACTH) and corticosterone release.	Corticosterone	131-145	neurotensin	Homo sapiens	48-59
9274996-12	1997	These enzymes, presumably cytochrome P450(11,18) mediate the hydroxylation and the oxidation at C11 and C18, the final steps in the biogenesis of aldosterone, corticosterone and cortisol.	Corticosterone	159-173	RNA polymerase III subunit K	Homo sapiens	96-99
9274996-12	1997	These enzymes, presumably cytochrome P450(11,18) mediate the hydroxylation and the oxidation at C11 and C18, the final steps in the biogenesis of aldosterone, corticosterone and cortisol.	Corticosterone	159-173	Bardet-Biedl syndrome 9	Homo sapiens	104-107
9231802-11	1997	In tissues of normal mice, corticosterone inhibited both basal and CRH-stimulated ACTH release more potently in PHc than in PI.	Corticosterone	27-41	corticotropin releasing hormone	Mus musculus	67-70
9231802-12	1997	Furthermore, the feedback capacity of corticosterone to restrain both basal and CRH-stimulated ACTH release was highly impaired in tissues of transgenic mice, whereas the feedback in PHc appeared to be more affected than that in the PI of these animals.	Corticosterone	38-52	corticotropin releasing hormone	Mus musculus	80-83
9787250-1	1997	Previous reports indicate that the central nucleus of the amygdala (CeA) stimulates adrenocorticotropin and corticosterone secretion, suggesting a role for this region in central hypothalamo-pituitary-adrenocortical (HPA) stress regulation.	Corticosterone	108-122	carcinoembryonic antigen gene family 4	Rattus norvegicus	68-71
9202299-1	1997	In astrocytes, nerve growth factor (NGF) synthesis has been described to be stimulated by the cytokines interleukin-1beta (IL-1beta) and transforming growth factor-beta1 (TGF-beta1) and inhibited by corticosterone.	Corticosterone	199-213	nerve growth factor	Homo sapiens	15-34
9249578-4	1997	The induction of corticosterone was only slightly reduced (14%) in IL-1 beta -/- mice.	Corticosterone	17-31	interleukin 1 beta	Mus musculus	67-76
9309537-8	1997	Concomitant infusion of ovine CRH (oCRH) and DEX for 3 days caused impaired BW gain, adrenal atrophy in addition to further reduction of plasma corticosterone.	Corticosterone	144-158	corticotropin releasing hormone	Rattus norvegicus	30-33
9252095-7	1997	ODC activity was enhanced by the administration of corticosterone, AA-2414 (an antagonist of thromboxane (TX) A2) and TXB2, whereas the A-SPD level was reduced by corticosterone and AA-2414 treatment.	Corticosterone	51-65	ornithine decarboxylase, structural 1	Mus musculus	0-3
9252095-10	1997	Corticosterone and AA-2414 treatment may attenuate the LPS-induced production of eicosanoids, and enhance the LPS-induced ODC activation.	Corticosterone	0-14	ornithine decarboxylase, structural 1	Mus musculus	122-125
9202299-1	1997	In astrocytes, nerve growth factor (NGF) synthesis has been described to be stimulated by the cytokines interleukin-1beta (IL-1beta) and transforming growth factor-beta1 (TGF-beta1) and inhibited by corticosterone.	Corticosterone	199-213	nerve growth factor	Homo sapiens	36-39
9189267-2	1997	These effects are prevented by chronic replacement of corticosterone (CORT).	Corticosterone	54-68	cortistatin	Rattus norvegicus	70-74
9191104-5	1997	We hypothesized that if the glucocorticoid receptor is important as a mediator of the suppressive effect of corticosterone, this would be revealed by changed (enhanced) expression of 5-HT(1A) receptor mRNA in mice with a genetically changed glucocorticoid receptor status.	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 1	Mus musculus	28-51
9272634-5	1997	A 48-hour fast resulted in a 50% reduction in leptin, a 60% reduction in thyroxine, a 75% reduction in testosterone, and a 12-fold increase in corticosterone in both wildtype and NPY-knockout mice.	Corticosterone	143-157	neuropeptide Y	Mus musculus	179-182
9165036-6	1997	Conversely, administration of corticosterone increased pituitary GHRH-R mRNA levels in intact, as well as adrenalectomized rats.	Corticosterone	30-44	growth hormone releasing hormone receptor	Rattus norvegicus	65-71
9191104-5	1997	We hypothesized that if the glucocorticoid receptor is important as a mediator of the suppressive effect of corticosterone, this would be revealed by changed (enhanced) expression of 5-HT(1A) receptor mRNA in mice with a genetically changed glucocorticoid receptor status.	Corticosterone	108-122	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	183-200
9191104-5	1997	We hypothesized that if the glucocorticoid receptor is important as a mediator of the suppressive effect of corticosterone, this would be revealed by changed (enhanced) expression of 5-HT(1A) receptor mRNA in mice with a genetically changed glucocorticoid receptor status.	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 1	Mus musculus	241-264
9191104-7	1997	The 5-HT(1A) receptor mRNA levels were responsive to corticosterone, as adrenalectomy led to increased levels of hippocampal 5-HT(1A) receptor mRNA both in wild-type as in heterozygous knockout mice.	Corticosterone	53-67	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	4-21
9191104-7	1997	The 5-HT(1A) receptor mRNA levels were responsive to corticosterone, as adrenalectomy led to increased levels of hippocampal 5-HT(1A) receptor mRNA both in wild-type as in heterozygous knockout mice.	Corticosterone	53-67	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	125-142
9151715-5	1997	This corticosterone replacement could protect healthy granule cells promptly and continuously against hormone-deficient apoptosis, because the normal glucocorticoid receptor immunoreactivity within the granule cell nuclei, which disappeared after ADX, was identified 1 hr after corticosterone replacement was started, and this effect persisted for several days.	Corticosterone	5-19	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	150-173
9151722-6	1997	The 5-HT2C receptor mRNA rhythm, however, is suppressed by even modest constant elevations of corticosterone (adrenalectomy + pellet) or with elevated corticosterone during the daytime (8 A.M.), whereas a normal rhythm exists in animals that have the same dose of corticosterone in the evening (6 P.M.).	Corticosterone	94-108	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	4-19
9151722-6	1997	The 5-HT2C receptor mRNA rhythm, however, is suppressed by even modest constant elevations of corticosterone (adrenalectomy + pellet) or with elevated corticosterone during the daytime (8 A.M.), whereas a normal rhythm exists in animals that have the same dose of corticosterone in the evening (6 P.M.).	Corticosterone	151-165	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	4-19
9151722-6	1997	The 5-HT2C receptor mRNA rhythm, however, is suppressed by even modest constant elevations of corticosterone (adrenalectomy + pellet) or with elevated corticosterone during the daytime (8 A.M.), whereas a normal rhythm exists in animals that have the same dose of corticosterone in the evening (6 P.M.).	Corticosterone	151-165	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	4-19
9151722-7	1997	Thus, animals showing even a transient daytime corticosterone nadir exhibit normal hippocampal 5-HT2C receptor mRNA rhythms, even in the presence of overt corticosterone hypersecretion.	Corticosterone	47-61	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	95-110
9151722-8	1997	Chronic food restriction also abolishes the normal diurnal variation in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor mRNAs and produces, unusually, both elevated corticosterone and increased GR.	Corticosterone	189-203	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	109-111
9151722-8	1997	Chronic food restriction also abolishes the normal diurnal variation in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor mRNAs and produces, unusually, both elevated corticosterone and increased GR.	Corticosterone	189-203	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	117-143
9151762-7	1997	Moreover, intracerebroventricularly CRH-treated rats showed elevated free corticosterone levels with no apparent diurnal rhythm.	Corticosterone	74-88	corticotropin releasing hormone	Rattus norvegicus	36-39
9202299-3	1997	Calcitriol stimulated NGF secretion, whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the NGF secretion induced by IL-1beta, calcitriol, and TGF-beta1.	Corticosterone	45-59	nerve growth factor	Homo sapiens	84-87
9202299-3	1997	Calcitriol stimulated NGF secretion, whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the NGF secretion induced by IL-1beta, calcitriol, and TGF-beta1.	Corticosterone	45-59	nerve growth factor	Homo sapiens	84-87
9202299-3	1997	Calcitriol stimulated NGF secretion, whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the NGF secretion induced by IL-1beta, calcitriol, and TGF-beta1.	Corticosterone	45-59	interleukin 1 beta	Homo sapiens	148-156
9151762-9	1997	Although free corticosterone levels reached similar peak concentrations in both intracerebroventricularly vehicle- and CRH-infused groups after LPS, this response was delayed significantly by approximately 1 hr in the intracerebroventricularly CRH-treated animals.	Corticosterone	14-28	corticotropin releasing hormone	Rattus norvegicus	119-122
9202299-3	1997	Calcitriol stimulated NGF secretion, whereas corticosterone reduced basal levels of NGF secretion as well as inhibited the NGF secretion induced by IL-1beta, calcitriol, and TGF-beta1.	Corticosterone	45-59	transforming growth factor beta 1	Homo sapiens	174-183
9223031-2	1997	Nitric oxide modulates the stimulated release of CRH from the rat hypothalamus in vitro, which suggests its role in regulating the secretion of ACTH from the pituitary corticotrops and of corticosterone from the adrenal cortex.	Corticosterone	188-202	corticotropin releasing hormone	Rattus norvegicus	49-52
9202299-5	1997	Moreover, calcitriol not only counteracted the inhibitory effect of corticosterone on NGF secretion stimulated by TGF-beta1 but even augmented it to a level more than threefold higher than that reached with TGF-beta1 alone.	Corticosterone	68-82	nerve growth factor	Homo sapiens	86-89
9202299-5	1997	Moreover, calcitriol not only counteracted the inhibitory effect of corticosterone on NGF secretion stimulated by TGF-beta1 but even augmented it to a level more than threefold higher than that reached with TGF-beta1 alone.	Corticosterone	68-82	transforming growth factor beta 1	Homo sapiens	114-123
9202299-6	1997	Due to the trophic effect of NGF on basal forebrain cholinergic neurons, these findings might be of therapeutic relevance under conditions where cholinergic function is impaired and the endogenous levels of corticosterone, IL-1beta, or TGF-beta1 are elevated.	Corticosterone	207-221	nerve growth factor	Homo sapiens	29-32
9153648-5	1997	In the intact animal, corticosterone increased messenger RNA levels for NR2A and NR2B but not NR1 subunits of the N-methyl-D-aspartate receptor in all regions of the hippocampus.	Corticosterone	22-36	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	72-76
9153648-5	1997	In the intact animal, corticosterone increased messenger RNA levels for NR2A and NR2B but not NR1 subunits of the N-methyl-D-aspartate receptor in all regions of the hippocampus.	Corticosterone	22-36	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	81-85
9153648-10	1997	These data suggest that the effects of corticosterone on hippocampal function are mediated, in part, by parallel increases in NR2A and NR2B subunit levels and the number of receptor channel binding sites.	Corticosterone	39-53	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	126-130
9153648-10	1997	These data suggest that the effects of corticosterone on hippocampal function are mediated, in part, by parallel increases in NR2A and NR2B subunit levels and the number of receptor channel binding sites.	Corticosterone	39-53	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	135-139
9192395-3	1997	Corticosterone replacement to adrenalectomized rats restored the increased levels of TAT mRNA in the obese animals.	Corticosterone	0-14	tyrosine aminotransferase	Rattus norvegicus	85-88
9169859-0	1997	Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	39-43
9169859-0	1997	Corticosterone regulates expression of BDNF and trkB but not NT-3 and trkC mRNA in the rat hippocampus.	Corticosterone	0-14	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	48-52
9169859-5	1997	BDNF mRNA decreased after corticosterone administration dose dependently, resulting in a maximal suppression of 35, 20, and 50% in dentate gyrus, CA3, and CA1, respectively.	Corticosterone	26-40	brain-derived neurotrophic factor	Rattus norvegicus	0-4
9169859-5	1997	BDNF mRNA decreased after corticosterone administration dose dependently, resulting in a maximal suppression of 35, 20, and 50% in dentate gyrus, CA3, and CA1, respectively.	Corticosterone	26-40	carbonic anhydrase 3	Rattus norvegicus	146-149
9169859-5	1997	BDNF mRNA decreased after corticosterone administration dose dependently, resulting in a maximal suppression of 35, 20, and 50% in dentate gyrus, CA3, and CA1, respectively.	Corticosterone	26-40	carbonic anhydrase 1	Rattus norvegicus	155-158
9169859-6	1997	Interestingly, trkB responded to corticosterone in an inverted U-shaped fashion in CA3 and dentate gyrus: the low dose of corticosterone increased trkB mRNA expression in both regions by approximately 30%, while the effect of the two higher doses was not different from the vehicle injected controls.	Corticosterone	33-47	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	15-19
9169859-6	1997	Interestingly, trkB responded to corticosterone in an inverted U-shaped fashion in CA3 and dentate gyrus: the low dose of corticosterone increased trkB mRNA expression in both regions by approximately 30%, while the effect of the two higher doses was not different from the vehicle injected controls.	Corticosterone	33-47	carbonic anhydrase 3	Rattus norvegicus	83-86
9169859-6	1997	Interestingly, trkB responded to corticosterone in an inverted U-shaped fashion in CA3 and dentate gyrus: the low dose of corticosterone increased trkB mRNA expression in both regions by approximately 30%, while the effect of the two higher doses was not different from the vehicle injected controls.	Corticosterone	122-136	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	15-19
9169859-6	1997	Interestingly, trkB responded to corticosterone in an inverted U-shaped fashion in CA3 and dentate gyrus: the low dose of corticosterone increased trkB mRNA expression in both regions by approximately 30%, while the effect of the two higher doses was not different from the vehicle injected controls.	Corticosterone	122-136	carbonic anhydrase 3	Rattus norvegicus	83-86
9169859-6	1997	Interestingly, trkB responded to corticosterone in an inverted U-shaped fashion in CA3 and dentate gyrus: the low dose of corticosterone increased trkB mRNA expression in both regions by approximately 30%, while the effect of the two higher doses was not different from the vehicle injected controls.	Corticosterone	122-136	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	147-151
9169859-7	1997	In conclusion, we found differential effects of low and high doses of corticosterone on BDNF and trkB expression in hippocampus, which suggests involvement of a coordinated MR- and GR-mediated action.	Corticosterone	70-84	brain-derived neurotrophic factor	Rattus norvegicus	88-92
9169859-7	1997	In conclusion, we found differential effects of low and high doses of corticosterone on BDNF and trkB expression in hippocampus, which suggests involvement of a coordinated MR- and GR-mediated action.	Corticosterone	70-84	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	97-101
9203553-1	1997	Basal plasma ACTH and corticosterone levels are controlled by the suprachiasmatic nucleus (SCN), the site of the circadian pacemaker, resulting in a daily peak in plasma corticosterone and ACTH.	Corticosterone	22-36	proopiomelanocortin	Homo sapiens	189-193
9203553-1	1997	Basal plasma ACTH and corticosterone levels are controlled by the suprachiasmatic nucleus (SCN), the site of the circadian pacemaker, resulting in a daily peak in plasma corticosterone and ACTH.	Corticosterone	170-184	proopiomelanocortin	Homo sapiens	13-17
9203553-8	1997	Regression analysis of the relation ACTH-corticosterone before and after stress shows a changed pattern at ZT2, although at that time still no significant correlation between ACTH and corticosterone was detected.	Corticosterone	41-55	proopiomelanocortin	Homo sapiens	36-40
9203553-12	1997	(4) The present results therefore demonstrate SCN modulating corticosterone secretion by affecting ACTH secretion and changing the sensitivity of the adrenal cortex by means of a neuronal input.	Corticosterone	61-75	proopiomelanocortin	Homo sapiens	99-103
9129466-7	1997	GH significantly decreased serum total triiodothyronine concentrations and IGF-I significantly decreased serum corticosterone concentrations.	Corticosterone	111-125	insulin-like growth factor 1	Rattus norvegicus	75-80
9082970-5	1997	ET-1, ET-3 and BQ-3020 enhance aldosterone and corticosterone secretion by dispersed cells of the zona glomerulosa and zona fasciculata/reticularis, respectively.	Corticosterone	47-61	endothelin 1	Rattus norvegicus	0-10
9178432-1	1997	The 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) enzymes convert corticosterone and cortisol to 11-dehydrocorticosterone and cortisone, and are thought to convey extrinsic specificity to the mineralocorticoid receptor by limiting access of the relatively more abundant glucocorticoids to it.	Corticosterone	71-85	LOC443144	Ovis aries	197-223
9135096-1	1997	Corticotropin-releasing factor is known as a stress peptide which stimulates adrenocorticotropin and corticosterone release.	Corticosterone	101-115	corticotropin releasing hormone	Rattus norvegicus	0-30
9178432-10	1997	The NADP(+)-dependent activity had a Km for corticosterone of 4 +/- 1.3 nM for a Km for cortisol of 35.2 +/- 2 nM, 100-fold lower than that described for the 11 beta-HSD-1 in the liver of sheep and other species, and was more prevalent in the microsomes than the nuclei.	Corticosterone	44-58	11-beta-hydroxysteroid dehydrogenase 1	Ovis aries	158-171
9099681-7	1997	Although OCT2p is structurally related to OCT1r, the basolateral organic cation transporter from rat kidney, the transporters could be clearly discriminated pharmacologically with corticosterone, decynium22, and O-methylisoprenaline.	Corticosterone	180-194	solute carrier family 22 member 2	Rattus norvegicus	9-14
9105690-3	1997	Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippocampal subfields, effects partly reversed by corticosterone replacement.	Corticosterone	162-176	basigin (Ok blood group)	Rattus norvegicus	71-74
9159503-0	1997	Administration of corticosterone alters intracellular localization of brain-derived neurotrophic factor-like immunoreactivity in the rat brain.	Corticosterone	18-32	brain-derived neurotrophic factor	Rattus norvegicus	70-103
9159503-1	1997	We investigated the distribution of immunoreactivity for brain-derived neurotrophic factor (BDNF) in rat brain after peripheral administration of corticosterone or vehicle.	Corticosterone	146-160	brain-derived neurotrophic factor	Rattus norvegicus	57-90
9159503-1	1997	We investigated the distribution of immunoreactivity for brain-derived neurotrophic factor (BDNF) in rat brain after peripheral administration of corticosterone or vehicle.	Corticosterone	146-160	brain-derived neurotrophic factor	Rattus norvegicus	92-96
9159503-3	1997	In corticosterone-treated rats, BDNF-LI was markedly reduced in the nucleus and concomitantly increased in cytoplasm.	Corticosterone	3-17	brain-derived neurotrophic factor	Rattus norvegicus	32-36
9159503-4	1997	Western immunoblot study also demonstrated that corticosterone significantly reduced BDNF-LI in the nuclear fraction of the cerebral cortex and hippocampus.	Corticosterone	48-62	brain-derived neurotrophic factor	Rattus norvegicus	85-89
9212718-2	1997	The present work investigates: 1) the effect of the physiological glucocorticoid corticosterone (CORT) and the synthetic agonist dexamethasone (DEX) on latex beads phagocytosis by neonatal rat cortical astrocytes in culture, and 2) the expression of immunoreactive glucocorticoid receptors (GR) in astrocytes cultured in different media with or without a pulse application of CORT.	Corticosterone	81-95	cortistatin	Rattus norvegicus	97-101
9075719-10	1997	The GH responses to GHRP-6 were significantly greater in rats with low basal plasma ACTH and corticosterone levels than in rats with elevated ACTH and corticosterone levels (change in GH response, 119 +/- 27 vs. 29 +/- 7 ng/ml; P &lt; 0.01).	Corticosterone	93-107	gonadotropin releasing hormone receptor	Rattus norvegicus	4-6
9075719-10	1997	The GH responses to GHRP-6 were significantly greater in rats with low basal plasma ACTH and corticosterone levels than in rats with elevated ACTH and corticosterone levels (change in GH response, 119 +/- 27 vs. 29 +/- 7 ng/ml; P &lt; 0.01).	Corticosterone	93-107	gonadotropin releasing hormone receptor	Rattus norvegicus	20-22
9075719-10	1997	The GH responses to GHRP-6 were significantly greater in rats with low basal plasma ACTH and corticosterone levels than in rats with elevated ACTH and corticosterone levels (change in GH response, 119 +/- 27 vs. 29 +/- 7 ng/ml; P &lt; 0.01).	Corticosterone	151-165	gonadotropin releasing hormone receptor	Rattus norvegicus	20-22
9122256-9	1997	The IL-1beta-deficient mice also responded to LPS challenge with significantly higher serum corticosterone and with lower serum tumor necrosis factor type alpha levels than the wild-type mice.	Corticosterone	92-106	interleukin 1 beta	Mus musculus	4-12
9122256-9	1997	The IL-1beta-deficient mice also responded to LPS challenge with significantly higher serum corticosterone and with lower serum tumor necrosis factor type alpha levels than the wild-type mice.	Corticosterone	92-106	toll-like receptor 4	Mus musculus	46-49
9122256-10	1997	The data suggest that, in the redundant cascade of proinflammatory cytokines, IL-1beta plays an important but not obligatory role in fever induction by LPS or IL-1alpha, as well as in the induction of serum tumor necrosis factor type alpha and corticosterone responses either by LPS or by IL-1alpha or IL-1beta.	Corticosterone	244-258	interleukin 1 beta	Mus musculus	78-86
9145302-8	1997	Binding experiments with [3H]-corticosterone demonstrated the presence of not only GR but also mineralocorticoid receptor (MR): the dissociation constants (Kd) and the number of binding sites (Bmax) were 0.8 nM and 15 fmol/mg protein for MR and 5.0 nM and 73 fmol/mg protein for GR, respectively.	Corticosterone	30-44	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	83-85
9145302-8	1997	Binding experiments with [3H]-corticosterone demonstrated the presence of not only GR but also mineralocorticoid receptor (MR): the dissociation constants (Kd) and the number of binding sites (Bmax) were 0.8 nM and 15 fmol/mg protein for MR and 5.0 nM and 73 fmol/mg protein for GR, respectively.	Corticosterone	30-44	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	95-121
9145302-8	1997	Binding experiments with [3H]-corticosterone demonstrated the presence of not only GR but also mineralocorticoid receptor (MR): the dissociation constants (Kd) and the number of binding sites (Bmax) were 0.8 nM and 15 fmol/mg protein for MR and 5.0 nM and 73 fmol/mg protein for GR, respectively.	Corticosterone	30-44	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	123-125
9145302-15	1997	In conclusion, it is suggested that GR and MR mediated the opposite effects of corticosterone on the functions of microglial cells; the hormone acted as an inhibitor through GR and as an stimulator through MR.	Corticosterone	79-93	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	36-38
9145302-15	1997	In conclusion, it is suggested that GR and MR mediated the opposite effects of corticosterone on the functions of microglial cells; the hormone acted as an inhibitor through GR and as an stimulator through MR.	Corticosterone	79-93	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	43-45
9145302-15	1997	In conclusion, it is suggested that GR and MR mediated the opposite effects of corticosterone on the functions of microglial cells; the hormone acted as an inhibitor through GR and as an stimulator through MR.	Corticosterone	79-93	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	174-176
9145302-15	1997	In conclusion, it is suggested that GR and MR mediated the opposite effects of corticosterone on the functions of microglial cells; the hormone acted as an inhibitor through GR and as an stimulator through MR.	Corticosterone	79-93	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	206-208
9116047-3	1997	Using in situ hybridization histochemistry, we noted a pronounced increase in signal for HO-2 mRNA in the brain of 14-day-old rats postnatally treated with corticosterone (5 microg/g, 4 x, starting 24-36 h after birth).	Corticosterone	156-170	heme oxygenase 2	Rattus norvegicus	89-93
9000696-8	1997	In conclusion, intact adrenal glands, and probably circulating corticosterone in particular, are necessary for the establishment of most of the hormonal and metabolic effects induced by chronic ICV infusion of NPY in normal rats.	Corticosterone	63-77	neuropeptide Y	Rattus norvegicus	210-213
9048602-4	1997	Elevations in plasma corticosterone levels do not seem to play a role either, because icv IL-1 beta is able to blunt hCG-induced T secretion in animals whose corticosterone has been removed by adrenalectomy or reduced by the administration of antibodies to CRF.	Corticosterone	158-172	interleukin 1 beta	Rattus norvegicus	90-99
9048608-6	1997	When increases in corticosterone were eliminated by adrenalectomy or controlled by adrenalectomy with low level corticosterone replacement, increases in resting plasma ACTH and anterior pituitary POMC messenger RNA expression occurred with protein deprivation that could be statistically discriminated by regression analysis from changes due to caloric restriction (pair-feeding) and overt glucocorticoid feedback resistance.	Corticosterone	18-32	proopiomelanocortin	Rattus norvegicus	196-200
9048755-12	1997	The present data show that MDMA may affect 5-HT1A receptors in a regionally dependent manner, notably through a drug effect on corticosterone release, which attenuates 5-HT1A receptor gene transcription selectively in the hippocampus.	Corticosterone	127-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	43-49
9048755-12	1997	The present data show that MDMA may affect 5-HT1A receptors in a regionally dependent manner, notably through a drug effect on corticosterone release, which attenuates 5-HT1A receptor gene transcription selectively in the hippocampus.	Corticosterone	127-141	5-hydroxytryptamine receptor 1A	Rattus norvegicus	168-174
9068053-1	1997	The effects of exogenous naloxone and adrenocorticotropin (ACTH) on circulating concentrations of corticosterone and glucose in broilers were determined.	Corticosterone	98-112	proopiomelanocortin	Homo sapiens	59-63
9068053-7	1997	Intramuscular injections of naloxone significantly reduced subsequent ACTH-stimulated increases in serum corticosterone; however, when followed by saline, naloxone elevated corticosterone by 90 min after the final injection of saline.	Corticosterone	105-119	proopiomelanocortin	Homo sapiens	70-74
9009318-4	1997	In this study, we show that corticosterone differentially affects the stability of mRNAs of several recombinant gamma interferon (rIFN-gamma)-induced genes.	Corticosterone	28-42	interferon gamma	Mus musculus	112-140
9009318-5	1997	Treatment of macrophages from BCG-susceptible mice with corticosterone accelerates the decay of Nramp1 mRNA.	Corticosterone	56-70	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	96-102
9009318-6	1997	The mRNA of IFN-gamma-induced genes of macrophages from BCG-resistant mice was more stable than the mRNA of macrophages from BCG-susceptible mice in the presence or absence of corticosterone.	Corticosterone	176-190	interferon gamma	Mus musculus	12-21
9059958-7	1997	However, anti-TNF treatments significantly attenuated the inflammation-induced rise in plasma corticosterone in bile duct resected rats.	Corticosterone	94-108	tumor necrosis factor	Rattus norvegicus	14-17
9041362-1	1997	Acute administration of neuropeptide Y(NPY) into the hypothalamus and third cerebral ventricle (ICV) increases respiratory quotient, reduces energy expenditure and increases circulating, insulin, glucagon and corticosterone.	Corticosterone	209-223	neuropeptide Y	Rattus norvegicus	39-42
9067459-1	1997	Sustained high levels of corticosterone (CORT), one of the major stress-induced hormones in the rat, were suggested as generating "accelerated brain aging" and were shown to induce both specific brain changes in the hippocampus and learning impairments in young and middle-aged Fischer-344 rats.	Corticosterone	25-39	cortistatin	Rattus norvegicus	41-45
9051584-14	1997	Incubation with concentrations of corticosterone and prolactin similar to those observed in plasma immediately after exercise (corticosterone, 0.72 mumol l-1; prolactin, 88 pmol l-1) raised the chemotactic capacity with respect to that following incubation with the basal concentrations of the hormones in control animals (90 +/- 9 vs. 37 +/- 4 for corticosterone; 72 +/- 9 vs. 41 +/- 4 for prolactin).	Corticosterone	34-48	prolactin	Mus musculus	159-168
9051584-14	1997	Incubation with concentrations of corticosterone and prolactin similar to those observed in plasma immediately after exercise (corticosterone, 0.72 mumol l-1; prolactin, 88 pmol l-1) raised the chemotactic capacity with respect to that following incubation with the basal concentrations of the hormones in control animals (90 +/- 9 vs. 37 +/- 4 for corticosterone; 72 +/- 9 vs. 41 +/- 4 for prolactin).	Corticosterone	34-48	prolactin	Mus musculus	159-168
9051584-14	1997	Incubation with concentrations of corticosterone and prolactin similar to those observed in plasma immediately after exercise (corticosterone, 0.72 mumol l-1; prolactin, 88 pmol l-1) raised the chemotactic capacity with respect to that following incubation with the basal concentrations of the hormones in control animals (90 +/- 9 vs. 37 +/- 4 for corticosterone; 72 +/- 9 vs. 41 +/- 4 for prolactin).	Corticosterone	127-141	prolactin	Mus musculus	53-62
9051584-14	1997	Incubation with concentrations of corticosterone and prolactin similar to those observed in plasma immediately after exercise (corticosterone, 0.72 mumol l-1; prolactin, 88 pmol l-1) raised the chemotactic capacity with respect to that following incubation with the basal concentrations of the hormones in control animals (90 +/- 9 vs. 37 +/- 4 for corticosterone; 72 +/- 9 vs. 41 +/- 4 for prolactin).	Corticosterone	127-141	prolactin	Mus musculus	53-62
9099047-4	1997	We found that the fetal pituitary allografts released adrenal corticotropin (ACTH) and corticosterone in response to stimulation by corticotropin-releasing hormone (CRH), and released corticosterone alone in response to insulin-induced hypoglycemia.	Corticosterone	87-101	corticotropin releasing hormone	Rattus norvegicus	132-163
9099047-4	1997	We found that the fetal pituitary allografts released adrenal corticotropin (ACTH) and corticosterone in response to stimulation by corticotropin-releasing hormone (CRH), and released corticosterone alone in response to insulin-induced hypoglycemia.	Corticosterone	87-101	corticotropin releasing hormone	Rattus norvegicus	165-168
9191978-9	1997	The enhanced GFAP-ir was attenuated after four days of treatment with a corticosterone (CORT) pellet implant, producing a pharmacological increase in peripheral circulating CORT.	Corticosterone	72-86	glial fibrillary acidic protein	Mus musculus	13-17
9191978-9	1997	The enhanced GFAP-ir was attenuated after four days of treatment with a corticosterone (CORT) pellet implant, producing a pharmacological increase in peripheral circulating CORT.	Corticosterone	88-92	glial fibrillary acidic protein	Mus musculus	13-17
9191978-9	1997	The enhanced GFAP-ir was attenuated after four days of treatment with a corticosterone (CORT) pellet implant, producing a pharmacological increase in peripheral circulating CORT.	Corticosterone	173-177	glial fibrillary acidic protein	Mus musculus	13-17
9643655-0	1997	Corticosterone induces hypoactivity of prolactin-immunoreactive cells.	Corticosterone	0-14	prolactin	Rattus norvegicus	39-48
9643655-7	1997	These results demonstrate an inhibitory effect of corticosterone on the activity of rat pituitary prolactin cells and suggest that corticosterone induces hypoactivity by acting on the pituitary prolactin cells of male rats.	Corticosterone	50-64	prolactin	Rattus norvegicus	98-107
9643655-7	1997	These results demonstrate an inhibitory effect of corticosterone on the activity of rat pituitary prolactin cells and suggest that corticosterone induces hypoactivity by acting on the pituitary prolactin cells of male rats.	Corticosterone	131-145	prolactin	Rattus norvegicus	98-107
9643655-7	1997	These results demonstrate an inhibitory effect of corticosterone on the activity of rat pituitary prolactin cells and suggest that corticosterone induces hypoactivity by acting on the pituitary prolactin cells of male rats.	Corticosterone	131-145	prolactin	Rattus norvegicus	194-203
9039004-0	1997	Corticosterone inhibition of osmotically stimulated vasopressin from hypothalamic-neurohypophysial explants.	Corticosterone	0-14	arginine vasopressin	Rattus norvegicus	52-63
9039004-4	1997	AVP release was not increased during osmotic stimulation in the presence of corticosterone (Cort) and was 20-30% lower than osmotically stimulated release observed in the absence of Cort.	Corticosterone	76-90	arginine vasopressin	Rattus norvegicus	0-3
9039004-5	1997	RU-486 reversed the inhibitory effect of corticosterone on AVP release.	Corticosterone	41-55	arginine vasopressin	Rattus norvegicus	59-62
8977428-2	1997	Alcohol consumption by pregnant dams led to a 5-fold elevation of plasma corticosterone (CORT) levels and significantly decreased fetal CORT levels.	Corticosterone	73-87	cortistatin	Rattus norvegicus	89-93
9037138-8	1997	Similarly, ET-1 enhanced corticosterone output from the regenerating adrenal cortex, and this could be prevented by the addition of nifedipine.	Corticosterone	25-39	endothelin 1	Rattus norvegicus	11-15
9287082-9	1997	The training-induced enhancement of PKCgamma-ir in the CA1 region was similar in trained and corticosterone-treated trained animals, but the learning-induced PKCgamma-ir response in the posterior CA3 area was absent after corticosterone pretreatment.	Corticosterone	93-107	protein kinase C, gamma	Rattus norvegicus	158-166
9287082-9	1997	The training-induced enhancement of PKCgamma-ir in the CA1 region was similar in trained and corticosterone-treated trained animals, but the learning-induced PKCgamma-ir response in the posterior CA3 area was absent after corticosterone pretreatment.	Corticosterone	93-107	carbonic anhydrase 3	Rattus norvegicus	196-199
9287082-9	1997	The training-induced enhancement of PKCgamma-ir in the CA1 region was similar in trained and corticosterone-treated trained animals, but the learning-induced PKCgamma-ir response in the posterior CA3 area was absent after corticosterone pretreatment.	Corticosterone	222-236	carbonic anhydrase 3	Rattus norvegicus	196-199
9023740-0	1997	Transient suppression of resting corticosterone levels induces sustained increase of AVP stores in hypothalamic CRH-neurons of rats.	Corticosterone	33-47	corticotropin releasing hormone	Rattus norvegicus	112-115
9023740-6	1997	In contrast, resting pm levels of ACTH and corticosterone (CORT) were suppressed only during the first 2 days.	Corticosterone	43-57	cortistatin	Rattus norvegicus	59-63
8996231-2	1997	The increased secretion of corticosterone (CORT) that results appeared to protect animals against HU toxicity, which was dramatically enhanced in adrenalectomized (ADX) rats.	Corticosterone	27-41	cortistatin	Rattus norvegicus	43-47
9032771-6	1997	Furthermore, SEB challenge increased plasma ACTH, which accounted for the increased plasma corticosterone, and increased the expression of c-fos in the PVN region of the hypothalamus.	Corticosterone	91-105	pro-opiomelanocortin-alpha	Mus musculus	44-48
8976527-0	1997	Role of corticosterone in the behavioral effects of central interleukin-1 beta.	Corticosterone	8-22	interleukin 1 beta	Rattus norvegicus	60-78
8976527-6	1997	To verify that corticosterone was responsible for inhibiting the effects of IL-1 beta, corticosterone pellets or placebos were implanted i.p.	Corticosterone	15-29	interleukin 1 beta	Rattus norvegicus	76-85
8976527-10	1997	Corticosterone replacement, however, reversed this effect in ADX rats, confirming that corticosterone modulates the behavioral effects of peripheral IL-1 beta.	Corticosterone	0-14	interleukin 1 beta	Rattus norvegicus	149-158
8976527-10	1997	Corticosterone replacement, however, reversed this effect in ADX rats, confirming that corticosterone modulates the behavioral effects of peripheral IL-1 beta.	Corticosterone	87-101	interleukin 1 beta	Rattus norvegicus	149-158
8976527-16	1997	These results are interpreted to indicate that corticosterone inhibits the behavioral effects of IL-1 beta in the periphery and, perhaps, in the CNS.	Corticosterone	47-61	interleukin 1 beta	Rattus norvegicus	97-106
9264152-1	1997	Pyramidal cells in the CA1 hippocampal area express both mineralo- and glucocorticoid receptors (MRs and GRs respectively) to which the rat adrenal hormone corticosterone binds effectively.	Corticosterone	156-170	carbonic anhydrase 1	Rattus norvegicus	23-26
9029721-4	1997	11 beta-Hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) catalyzes the rapid inactivation of cortisol and corticosterone to inert 11 keto-products.	Corticosterone	108-122	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	0-7
9029721-4	1997	11 beta-Hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) catalyzes the rapid inactivation of cortisol and corticosterone to inert 11 keto-products.	Corticosterone	108-122	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	45-57
9051756-2	1996	A possible direct effect of the glucocorticoid corticosterone (COR) on AChRs of mouse C2C12 myotubes was studied in the cell-attached patch-clamp configuration.	Corticosterone	47-61	distribution of corticosterone in adrenal cortex cells	Mus musculus	63-66
8955207-0	1996	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.	Corticosterone	86-100	tumor necrosis factor	Mus musculus	0-3
8955207-0	1996	TNF receptor p55 plays a major role in centrally mediated increases of serum IL-6 and corticosterone after intracerebroventricular injection of TNF.	Corticosterone	86-100	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	13-16
8955207-4	1996	However, a normal CS response was observed in p55 -/- mice after LPS (2.5 microg, i.c.v.).	Corticosterone	18-20	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	46-49
8955207-8	1996	induced a marked elevation in CS and IL-6, alpha p75 induced CS (although less than alpha p55) but no IL-6.	Corticosterone	61-63	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	49-52
8955056-3	1996	Compared with nontransgenic littermates, gp120 transgenic mice showed significant increases in plasma corticosterone and adrenocorticotrophic hormone (ACTH) levels and pituitary ACTH content.	Corticosterone	102-116	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	41-46
9117393-4	1996	Stress-induced levels of corticosterone were significantly lower in late pregnant and early lactating rats compared with the levels in virgin females, and this correlated with a marked attenuation of stress-induced c-fos mRNA expression in the parvocellular division of the PVN.	Corticosterone	25-39	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	215-220
8940387-8	1996	These results suggest that down-regulation of the Ke 6 gene may lead to elevated corticosterone levels, mediated through an inhibition of 11betaHSD-1 activity.	Corticosterone	81-95	H2-K region expressed gene 6	Mus musculus	50-54
8940387-8	1996	These results suggest that down-regulation of the Ke 6 gene may lead to elevated corticosterone levels, mediated through an inhibition of 11betaHSD-1 activity.	Corticosterone	81-95	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	138-149
8940403-7	1996	Because ginkgolides reduced the adrenal PBR expression and corticosterone synthesis despite the presence of high levels of steroidogenic acute regulatory protein, these data demonstrate that PBR is indispensable for normal adrenal function.	Corticosterone	59-73	translocator protein	Rattus norvegicus	191-194
9421133-0	1997	TNF-alpha-induced corticosterone elevation but not serum protein or corticosteroid binding globulin reduction is vagally mediated.	Corticosterone	18-32	tumor necrosis factor	Homo sapiens	0-9
9421133-3	1997	Because some effects of TNF-alpha are mediated, at least in part, by the brain [plasma corticosterone (CORT) elevation] and some are mediated by peripheral organs [reduction of serum protein and corticosteroid binding globulin (CBG)], we also investigated whether the effects of vagotomy are specific to those defense processes mediated by the brain.	Corticosterone	87-101	tumor necrosis factor	Homo sapiens	24-33
9421133-3	1997	Because some effects of TNF-alpha are mediated, at least in part, by the brain [plasma corticosterone (CORT) elevation] and some are mediated by peripheral organs [reduction of serum protein and corticosteroid binding globulin (CBG)], we also investigated whether the effects of vagotomy are specific to those defense processes mediated by the brain.	Corticosterone	87-101	cortistatin	Homo sapiens	103-107
8990073-5	1996	This study investigated corticosterone (CORT) responses to restraint stress and GR and MR gene expression in areas of the brain postulated to mediate the central effects of corticosteroids on (i) HPA axis suppression (hippocampus), and (ii) blood pressure (organ vasculosum of the lamina terminalis (OVLT), sub-commissural organ, area postrema and nucleus tractus solitarius).	Corticosterone	24-38	cortistatin	Rattus norvegicus	40-44
8938747-5	1996	Neurotensin also produced an increase in serum corticosterone concentration and decrease in body temperature.	Corticosterone	47-61	neurotensin	Rattus norvegicus	0-11
8938747-6	1996	The intraperitoneal administration of SR48692, a non-peptide neurotensin receptor antagonist, blocked the neurotensin-induced corticosterone secretion and significantly reduced the number of neurotensin-induced Fos-positive and Zif268-positive neurons in the amygdaloid complex.	Corticosterone	126-140	neurotensin	Rattus norvegicus	106-117
8938747-6	1996	The intraperitoneal administration of SR48692, a non-peptide neurotensin receptor antagonist, blocked the neurotensin-induced corticosterone secretion and significantly reduced the number of neurotensin-induced Fos-positive and Zif268-positive neurons in the amygdaloid complex.	Corticosterone	126-140	neurotensin	Rattus norvegicus	106-117
8938747-7	1996	A significant positive correlation was found between the number of Fos-positive nuclei in the central or basolateral nucleus of the amygdala and the serum corticosterone concentration.	Corticosterone	155-169	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-70
8938747-9	1996	Our findings indicate that the central role of neurotensin in increasing serum corticosterone involves the induction of Fos in the central and basolateral nuclei of the amygdala.	Corticosterone	79-93	neurotensin	Rattus norvegicus	47-58
8938747-9	1996	Our findings indicate that the central role of neurotensin in increasing serum corticosterone involves the induction of Fos in the central and basolateral nuclei of the amygdala.	Corticosterone	79-93	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	120-123
9116202-2	1996	IL-2 induced increases in plasma levels of adrenocorticotropic hormone (ACTH, up to two-fold) and corticosterone (up to four-fold) compared with controls.	Corticosterone	98-112	interleukin 2	Rattus norvegicus	0-4
8955517-8	1996	The present results are in agreement with previous studies showing that elevations in corticosterone or an acute episode of experimentally induced stress in vivo causes a suppression in LTP in the hippocampal CA1 field, in vitro.	Corticosterone	86-100	carbonic anhydrase 1	Rattus norvegicus	209-212
8932995-4	1996	Normally placental 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD-2) protects the fetus from the normally higher maternal levels of glucocorticoids by inactivating corticosterone and cortisol to inert 11-keto products.	Corticosterone	174-188	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	19-26
8932995-4	1996	Normally placental 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD-2) protects the fetus from the normally higher maternal levels of glucocorticoids by inactivating corticosterone and cortisol to inert 11-keto products.	Corticosterone	174-188	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	64-71
8969909-3	1996	Androstenedione, cortisol and corticosterone secreted into the medium in response to a subsequent 4 hour treatment with angiotensin II (10nM) indicated that the steroidogenic phenotype of NCI-H295 cells changes away from 17-deoxysteroid biosynthesis towards adrenal androgen production in response to forskolin.	Corticosterone	30-44	angiotensinogen	Homo sapiens	120-134
8969940-1	1996	11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action.	Corticosterone	131-145	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-7
8969940-1	1996	11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) catalyzes the interconversion of cortisol (F) to inactive cortisone (E) in man (corticosterone (B) to 11-dehydrocorticosterone (A) in rodents) and plays a crucial role in regulating corticosteroid hormone action.	Corticosterone	131-145	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	38-45
8969942-3	1996	We had previously shown that 11 alpha- and 11 beta-hydroxyprogesterone (11 alpha- and 11 beta-OHP) were (I) potent inhibitors of 11 beta-HSD (Isoforms 1 and 2) activity in vitro, (ii) able to confer mineralocorticoid (MC) activity upon corticosterone (B) in vivo and (iii) hypertensinogenic when chronically infused into Sprague-Dawley (SD) rats.	Corticosterone	236-250	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	43-50
8969942-3	1996	We had previously shown that 11 alpha- and 11 beta-hydroxyprogesterone (11 alpha- and 11 beta-OHP) were (I) potent inhibitors of 11 beta-HSD (Isoforms 1 and 2) activity in vitro, (ii) able to confer mineralocorticoid (MC) activity upon corticosterone (B) in vivo and (iii) hypertensinogenic when chronically infused into Sprague-Dawley (SD) rats.	Corticosterone	236-250	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	86-93
8969942-3	1996	We had previously shown that 11 alpha- and 11 beta-hydroxyprogesterone (11 alpha- and 11 beta-OHP) were (I) potent inhibitors of 11 beta-HSD (Isoforms 1 and 2) activity in vitro, (ii) able to confer mineralocorticoid (MC) activity upon corticosterone (B) in vivo and (iii) hypertensinogenic when chronically infused into Sprague-Dawley (SD) rats.	Corticosterone	236-250	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	86-93
8950098-8	1996	Moreover, a significant correlation existed between the number of Fos-ir neurons in the PVN and the plasma corticosterone level.	Corticosterone	107-121	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
9004247-3	1996	By contrast, following bilateral adrenalectomy, a significant increase (P &lt; 0.05) in the VP-parvicellular population (anterior, medial and periventricular subdivisions) was detected, which was reversed when the animals received daily doses of corticosterone.	Corticosterone	246-260	arginine vasopressin	Homo sapiens	92-94
8947932-3	1996	Interestingly, in vitro glucocorticoid receptor activation in these cultured striatal neurons by corticosterone potentiated this neuroadaptive effect of prior in vivo morphine exposure.	Corticosterone	97-111	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	24-47
8824343-3	1996	The efficacy of adrenalectomy (ADX) and chronic treatment with high doses of corticosterone (B) to regulate the gene transcription of CRH and corticosteroid receptors in the hypothalamic paraventricular nucleus (PVN) and hippocampus was studied in male and female rats under the conditions of deprivation of gonadectomy (GDX) and replacement with different gonadal steroids, such as estradiol (E2), progesterone (P), and dihydrotestosterone (DHT).	Corticosterone	77-91	corticotropin releasing hormone	Rattus norvegicus	134-137
8933365-12	1996	Since plasma corticosterone levels during this blockade are still low, it is assumed that brain glucocorticoid receptor occupation is reduced, while mineralocorticoid receptors are still substantially occupied.	Corticosterone	13-27	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	96-119
8933365-13	1996	Therefore the present results support the hypothesis that corticosterone through glucocorticoid receptor activation enhances 5-HT synthesis rate and release in the dorsal hippocampus.	Corticosterone	58-72	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	81-104
8930935-6	1996	Subsequent CRH (50 ng/kg) infused at 20.00 h provoked a minimal escape from DEX suppression, indicated by a slight increase in ACTH and corticosterone secretion.	Corticosterone	136-150	corticotropin releasing hormone	Rattus norvegicus	11-14
8969946-2	1996	Using the intact perfused rat adrenal preparation we showed that VIP is a vasodilator in this tissue, and stimulates aldosterone and corticosterone secretion.	Corticosterone	133-147	vasoactive intestinal peptide	Rattus norvegicus	65-68
8939483-0	1996	Reduced hippocampal in vitro CA1 long-term potentiation in rat offsprings with increased circulating corticosterone during neonatal life.	Corticosterone	101-115	carbonic anhydrase 1	Rattus norvegicus	29-32
8939483-3	1996	A significant (P &lt; 0.01) reduction in the magnitude of the long-term potentiation (LTP) of the CA1 population spike occurred in hippocampal slices obtained from 30-45 day old male corticosterone-nursed rats with respect to controls, while no significant difference occurred in the magnitude of the basal CA1 evoked extracellular somatic field potentials with respect to controls.	Corticosterone	183-197	carbonic anhydrase 1	Rattus norvegicus	98-101
8939483-3	1996	A significant (P &lt; 0.01) reduction in the magnitude of the long-term potentiation (LTP) of the CA1 population spike occurred in hippocampal slices obtained from 30-45 day old male corticosterone-nursed rats with respect to controls, while no significant difference occurred in the magnitude of the basal CA1 evoked extracellular somatic field potentials with respect to controls.	Corticosterone	183-197	carbonic anhydrase 1	Rattus norvegicus	307-310
8939483-4	1996	The results demonstrate that a moderate increase in plasma corticosterone during neonatal life, obtained through maternal milk, has long-lasting effects on the hippocampal CA1 synaptic plasticity.	Corticosterone	59-73	carbonic anhydrase 1	Rattus norvegicus	172-175
8939483-5	1996	In addition, these results together with our previous findings [Catalani, A. et al., Brain Res., 624 (1993) 209-215], demonstrating that 30 day old corticosterone-nursed offsprings perform better than controls in the place learning version of the Morris water maze, show no relationships between in vitro CA1 LTP induction and spatial learning in agreement with literature data.	Corticosterone	148-162	carbonic anhydrase 1	Rattus norvegicus	305-308
8930340-3	1996	At that time the level of 5-HT1A mRNA in the dorsal hippocampus (dentate gyrus and CA1) was twice the amount measured in low-aggressive mice that had long attack latency and high plasma corticosterone level.	Corticosterone	186-200	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	26-32
8916081-2	1996	injection of a missense oligodeoxynucleotide (MS-ODN) solution in rats, transcripts of the proinflammatory cytokine interleukin (IL)-6 were induced in hypothalamus, hippocampus, cortex and spleen and increased levels of circulating IL-6 and corticosterone were detected.	Corticosterone	241-255	interleukin 6	Rattus norvegicus	116-134
8938587-1	1996	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the interconversion of biologically active cortisol to inactive cortisone in man, and corticosterone to 11-dehydrocorticosterone in rodents.	Corticosterone	147-161	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-7
8981255-0	1996	Calcitonin decreases corticosterone-induced skeletal muscle calpain activity.	Corticosterone	21-35	calcitonin-related polypeptide alpha	Rattus norvegicus	0-10
8938587-1	1996	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the interconversion of biologically active cortisol to inactive cortisone in man, and corticosterone to 11-dehydrocorticosterone in rodents.	Corticosterone	147-161	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	38-45
8938587-2	1996	As such, this enzyme has been shown to confer aldosterone-selectivity on the mineralocorticoid receptor and to modulate cortisol/corticosterone access to the glucocorticoid receptor (GR).	Corticosterone	129-143	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	158-181
8938587-2	1996	As such, this enzyme has been shown to confer aldosterone-selectivity on the mineralocorticoid receptor and to modulate cortisol/corticosterone access to the glucocorticoid receptor (GR).	Corticosterone	129-143	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	183-185
8891601-0	1996	Involvement of 5-HT2A receptors in the elevation of rat serum corticosterone concentrations by quipazine and MK-212.	Corticosterone	62-76	5-hydroxytryptamine receptor 2A	Rattus norvegicus	15-21
8896808-5	1996	ANP was found to inhibit the water intake and corticosterone release induced by i.c.v.	Corticosterone	46-60	natriuretic peptide A	Rattus norvegicus	0-3
8876828-14	1996	ET-1-stimulated animals showed significant increases in plasma corticosterone and aldosterone concentrations.	Corticosterone	63-77	endothelin 1	Rattus norvegicus	0-4
10979043-0	1996	Effect of anti-TRH-receptor antibody on corticosterone release from rat adrenal gland in vitro.	Corticosterone	40-54	thyrotropin releasing hormone	Rattus norvegicus	15-18
8888001-1	1996	Previous studies using high-resistance sharp electrodes demonstrated that corticosterone (CORT) reduced GABAergic synaptic inhibition in CA1 neurons of the rat hippocampus in vitro.	Corticosterone	74-88	carbonic anhydrase 1	Rattus norvegicus	137-140
8888001-1	1996	Previous studies using high-resistance sharp electrodes demonstrated that corticosterone (CORT) reduced GABAergic synaptic inhibition in CA1 neurons of the rat hippocampus in vitro.	Corticosterone	90-94	carbonic anhydrase 1	Rattus norvegicus	137-140
8954594-16	1996	A third experiment demonstrated that IL-1 (2 micrograms/ kg, ip) significantly increased ACTH and corticosterone release in all prenatal treatment groups.	Corticosterone	98-112	interleukin 1 beta	Homo sapiens	37-41
8954594-17	1996	IL-1-induced corticosterone secretion was attenuated in P offspring, compared to both E and N rats.	Corticosterone	13-27	interleukin 1 beta	Homo sapiens	0-4
8954596-3	1996	In 5-day-old mice, corticosterone blood levels were markedly elevated 2 h following the last injection of IL-1.	Corticosterone	19-33	interleukin 1 complex	Mus musculus	106-110
8954596-6	1996	Furthermore, an inverse correlation between ACTH and corticosterone levels in blood and between ACTH content in the pituitary gland and corticosterone levels was observed in IL-1-treated mice.	Corticosterone	53-67	pro-opiomelanocortin-alpha	Mus musculus	44-48
8954596-6	1996	Furthermore, an inverse correlation between ACTH and corticosterone levels in blood and between ACTH content in the pituitary gland and corticosterone levels was observed in IL-1-treated mice.	Corticosterone	53-67	interleukin 1 complex	Mus musculus	174-178
8954596-6	1996	Furthermore, an inverse correlation between ACTH and corticosterone levels in blood and between ACTH content in the pituitary gland and corticosterone levels was observed in IL-1-treated mice.	Corticosterone	136-150	pro-opiomelanocortin-alpha	Mus musculus	96-100
8954596-6	1996	Furthermore, an inverse correlation between ACTH and corticosterone levels in blood and between ACTH content in the pituitary gland and corticosterone levels was observed in IL-1-treated mice.	Corticosterone	136-150	interleukin 1 complex	Mus musculus	174-178
10979043-1	1996	The effect of anti-thyrotropin-releasing hormone (TRH) receptor antibody on corticosterone release from the rat adrenal gland in vitro was studied.	Corticosterone	76-90	thyrotropin releasing hormone	Rattus norvegicus	50-53
8756550-3	1996	The objective of the present study was to confirm the direct action of corticosterone (B) on FSH beta-subunit mRNA in primary anterior pituitary cell culture and to assess whether the selective B-induced rise in FSH beta mRNA is mediated through altered stability of the FSH beta transcript.	Corticosterone	71-85	follicle stimulating hormone subunit beta	Rattus norvegicus	93-101
8757267-3	1996	Previously, we demonstrated a pronounced inhibitory effect of vasopressin (VP), released from SCN terminals in the dorsomedial hypothalamus, on the release of the adrenal hormone corticosterone.	Corticosterone	179-193	arginine vasopressin	Homo sapiens	62-73
8757267-3	1996	Previously, we demonstrated a pronounced inhibitory effect of vasopressin (VP), released from SCN terminals in the dorsomedial hypothalamus, on the release of the adrenal hormone corticosterone.	Corticosterone	179-193	arginine vasopressin	Homo sapiens	75-77
8757304-2	1996	Restraint stress (RST) was used to activate the hypothalamic-pituitary-adrenal axis and elevate corticosterone (CORT) levels in influenza A/Puerto Rico/8/34 (PR8) virus-infected C57BL/6 mice.	Corticosterone	96-110	cortistatin	Mus musculus	112-116
10979043-3	1996	TRH inhibited corticosterone release from the adrenal gland in a dose-related manner.	Corticosterone	14-28	thyrotropin releasing hormone	Rattus norvegicus	0-3
10979043-4	1996	The inhibitory effect of TRH on corticosterone release from the adrenal gland was prevented by the addition of anti-TRH-receptor antibody.	Corticosterone	32-46	thyrotropin releasing hormone	Rattus norvegicus	25-28
10979043-4	1996	The inhibitory effect of TRH on corticosterone release from the adrenal gland was prevented by the addition of anti-TRH-receptor antibody.	Corticosterone	32-46	thyrotropin releasing hormone	Rattus norvegicus	116-119
10979043-5	1996	The present findings suggest that TRH inhibits corticosterone release from the adrenal gland in vitro and its effect is mediated via TRH receptor.	Corticosterone	47-61	thyrotropin releasing hormone	Rattus norvegicus	34-37
10979043-5	1996	The present findings suggest that TRH inhibits corticosterone release from the adrenal gland in vitro and its effect is mediated via TRH receptor.	Corticosterone	47-61	thyrotropin releasing hormone	Rattus norvegicus	133-136
8877003-2	1996	In the present study we investigated whether prolonged subordination stress, presumably producing elevated plasma corticosterone levels (1) altered the immunocytochemical distribution of the Ca(2+)-binding proteins Calbindin-D28k (CBir) and Parvalbumin (PVir) in the rat hippocampus, and (2) induced ongoing neurodegenerative changes using a silver impregnation method.	Corticosterone	114-128	parvalbumin	Rattus norvegicus	241-252
8759750-6	1996	Cyanoketone, a corticosterone (CORT) synthesis inhibitor, significantly reduced the decrease in lymphocyte numbers observed during stress and significantly enhanced the increase in neutrophil numbers observed after the cessation of stress.	Corticosterone	15-29	cortistatin	Rattus norvegicus	31-35
8883857-9	1996	Our results indicate that corticoid receptors in the developing CA1 hippocampal region appear to be sensitive to circulating CS.	Corticosterone	125-127	carbonic anhydrase 1	Rattus norvegicus	64-67
8883857-10	1996	They also suggest that the relative ratio of GR and MR in the CA1 region may contribute to the enhanced and sustained CS response seen after a mild stressor in deprived animals.	Corticosterone	118-120	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	45-47
8883857-10	1996	They also suggest that the relative ratio of GR and MR in the CA1 region may contribute to the enhanced and sustained CS response seen after a mild stressor in deprived animals.	Corticosterone	118-120	carbonic anhydrase 1	Rattus norvegicus	62-65
8768691-8	1996	Steroids such as dexamethasone, corticosterone, hydrocortisone and, to a lesser extent, dehydroepiandosterone inhibited the stimulated release of CRF-BP from astrocytes.	Corticosterone	32-46	corticotropin releasing hormone binding protein	Rattus norvegicus	146-152
8713080-0	1996	Effects of steroids and verapamil on P-glycoprotein ATPase activity: progesterone, desoxycorticosterone, corticosterone and verapamil are mutually non-exclusive modulators.	Corticosterone	89-103	ATP binding cassette subfamily B member 1	Homo sapiens	37-51
8864491-2	1996	Corticosterone treatment significantly decreased the number of 5-HT1A receptor sites (Bmax = 108 +/- 8.20 fmol/mg protein and 152.31 +/- 13.36 fmol/mg protein in corticosterone- and vehicle-treated rats, respectively).	Corticosterone	0-14	5-hydroxytryptamine receptor 1A	Rattus norvegicus	63-69
8864491-2	1996	Corticosterone treatment significantly decreased the number of 5-HT1A receptor sites (Bmax = 108 +/- 8.20 fmol/mg protein and 152.31 +/- 13.36 fmol/mg protein in corticosterone- and vehicle-treated rats, respectively).	Corticosterone	162-176	5-hydroxytryptamine receptor 1A	Rattus norvegicus	63-69
8713080-7	1996	A similar non-competitive inhibition of progesterone-stimulated P-gp ATPase activity by desoxycorticosterone or by corticosterone leads to the conclusion that these steroids, although sharing related structures, have distinct modulating sites on P-gp.	Corticosterone	94-108	ATP binding cassette subfamily B member 1	Homo sapiens	64-68
8840120-4	1996	It was found that in rats that were repeatedly treated with corticosterone the number of 2-chloro-6-(1-piperazinyl)pyrazine HCl (MK 212)-induced, 5-HT2C receptor-mediated penile erections were reduced, whereas both MK 212 and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced 5-HT2A receptor-mediated head shakes were increased.	Corticosterone	60-74	5-hydroxytryptamine receptor 2C	Rattus norvegicus	146-152
8840120-4	1996	It was found that in rats that were repeatedly treated with corticosterone the number of 2-chloro-6-(1-piperazinyl)pyrazine HCl (MK 212)-induced, 5-HT2C receptor-mediated penile erections were reduced, whereas both MK 212 and (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced 5-HT2A receptor-mediated head shakes were increased.	Corticosterone	60-74	5-hydroxytryptamine receptor 2A	Rattus norvegicus	292-298
8840120-7	1996	The results suggest that 5-HT2A, 5-HT2C and postsynaptic 5-HT1A receptor-mediated behaviour can be modulated by repeated treatment with a high dose of corticosterone.	Corticosterone	151-165	5-hydroxytryptamine receptor 2A	Rattus norvegicus	25-31
8840120-7	1996	The results suggest that 5-HT2A, 5-HT2C and postsynaptic 5-HT1A receptor-mediated behaviour can be modulated by repeated treatment with a high dose of corticosterone.	Corticosterone	151-165	5-hydroxytryptamine receptor 2C	Rattus norvegicus	33-39
8840120-7	1996	The results suggest that 5-HT2A, 5-HT2C and postsynaptic 5-HT1A receptor-mediated behaviour can be modulated by repeated treatment with a high dose of corticosterone.	Corticosterone	151-165	5-hydroxytryptamine receptor 1A	Rattus norvegicus	57-63
8840131-1	1996	We have recently reported the presence of calcitonin gene-related peptide (CGRP)-containing nerve fibers in the frog adrenal gland and we have shown that CGRP is a potent stimulator of corticosterone and aldosterone secretion by adrenocortical cells.	Corticosterone	185-199	calcitonin related polypeptide alpha	Homo sapiens	42-73
8840131-1	1996	We have recently reported the presence of calcitonin gene-related peptide (CGRP)-containing nerve fibers in the frog adrenal gland and we have shown that CGRP is a potent stimulator of corticosterone and aldosterone secretion by adrenocortical cells.	Corticosterone	185-199	calcitonin related polypeptide alpha	Homo sapiens	154-158
8770940-4	1996	Delivery of LIF (1.2 microg/day) via implantation of subcutaneous osmotic pumps restored ACTH (p=0.006 vs PBS replacement) and corticosterone (p=0.02 vs PBS replacement) levels within three days.	Corticosterone	127-141	leukemia inhibitory factor	Mus musculus	12-15
8812298-10	1996	Corticosterone appears capable of interacting with at least two different neuronal mechanisms to regulate CRH mRNA levels: one is clearly seen in paraventricular neurosecretory neurons, where increasing plasma corticosteroid reduces CRH mRNA levels; the other, seen in neurons in the central nucleus of the amygdala, acts to increase them.	Corticosterone	0-14	corticotropin releasing hormone	Homo sapiens	106-109
8812298-10	1996	Corticosterone appears capable of interacting with at least two different neuronal mechanisms to regulate CRH mRNA levels: one is clearly seen in paraventricular neurosecretory neurons, where increasing plasma corticosteroid reduces CRH mRNA levels; the other, seen in neurons in the central nucleus of the amygdala, acts to increase them.	Corticosterone	0-14	corticotropin releasing hormone	Homo sapiens	233-236
8843017-4	1996	[3H]Corticosterone (CORT) binding capacity (Bmax) and affinity (Kd) were determined at 3 weeks old and adult ages by using saturation analysis.	Corticosterone	4-18	cortistatin	Rattus norvegicus	20-24
9807061-2	1996	While the underlying mechanism is still unclear, adrenal steroids appear to play a pivotal role in granule cell survival, as administration of the mineralocorticoid receptor (MR) agonists, corticosterone and aldosterone, to ADX rats results in protection against the ADX-induced effect.	Corticosterone	189-203	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	147-173
9807062-0	1996	Cholinergic Responsiveness of Rat CA1 Hippocampal Neurons In Vitro: Modulation by Corticosterone and Stress.	Corticosterone	82-96	carbonic anhydrase 1	Rattus norvegicus	34-37
9807062-2	1996	We found that corticosterone, administered to adrenalectomized rats in vivo, dose-dependently modulates carbachol responsiveness of CA1 hippocampal neurons, recorded subsequently in vitro.	Corticosterone	14-28	carbonic anhydrase 1	Rattus norvegicus	132-135
9807062-3	1996	Thus, the carbachol (3 microM) induced membrane depolarization in CA1 neurons was relatively large in hippocampal slices where either (almost) no corticosteroid receptors were activated (0-1 microg corticosterone/100g body weight) or where both MRs and GRs were occupied by high corticosterone doses (100-1000 microg/100g).	Corticosterone	198-212	carbonic anhydrase 1	Rattus norvegicus	66-69
9807062-3	1996	Thus, the carbachol (3 microM) induced membrane depolarization in CA1 neurons was relatively large in hippocampal slices where either (almost) no corticosteroid receptors were activated (0-1 microg corticosterone/100g body weight) or where both MRs and GRs were occupied by high corticosterone doses (100-1000 microg/100g).	Corticosterone	279-293	carbonic anhydrase 1	Rattus norvegicus	66-69
8663122-7	1996	The enzymatic characteristics of the expressed 11beta-HSD2/GFP fusion protein were undistinguishable from those of the native enzyme: high affinity for corticosterone (KM 8-10 nM), NAD dependence, and lack of reductase activity.	Corticosterone	152-166	11-beta-hydroxysteroid dehydrogenase type 2	Oryctolagus cuniculus	47-58
8864489-14	1996	IL-1 beta; (2) stimulation of corticosterone secretion by i.p.	Corticosterone	30-44	interleukin 1 beta	Rattus norvegicus	0-9
8764206-4	1996	Administration of TNF-alpha to bile duct- and sham-resected rats in vivo resulted in a similar increase in plasma adrenocorticotropic hormone levels in both groups of animals but significantly higher corticosterone levels in cholestatic rats, suggesting a direct steroidogenic effect of TNF-alpha in cholestatic rats.	Corticosterone	200-214	tumor necrosis factor	Rattus norvegicus	18-27
8793116-8	1996	In ADX animals given corticosterone in their drinking water, V1aR mRNA levels detected by in situ hybridization increased significantly over the ADX rats given saline.	Corticosterone	21-35	arginine vasopressin receptor 1A	Rattus norvegicus	61-65
8818401-5	1996	As key to the endocrine and behavioural adaptations occurring in these two animal models the hormone corticosterone (CORT) is considered.	Corticosterone	101-115	cortistatin	Homo sapiens	117-121
8764206-5	1996	This suggestion was confirmed in further experiments by the demonstration of TNF-alpha-induced corticosterone secretion in hypophysectomized cholestatic but not control rats.	Corticosterone	95-109	tumor necrosis factor	Rattus norvegicus	77-86
8764206-6	1996	Furthermore, a direct stimulatory effect of TNF-alpha on adrenal corticosterone secretion in vitro was noted only for cholestatic rats, possibly via augmented adrenal prostaglandin E2 (PGE2) production.	Corticosterone	65-79	tumor necrosis factor	Rattus norvegicus	44-53
8764206-7	1996	These results indicate that TNF-alpha has a direct stimulatory effect on adrenal corticosterone secretion in cholestatic rats, possibly due to augmented adrenal PGE2 release.	Corticosterone	81-95	tumor necrosis factor	Rattus norvegicus	28-37
8641180-1	1996	The 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta HSD-2) enzyme is thought to confer aldosterone specificity upon mineralocorticoid target tissues by protecting the mineralocorticoid receptor from binding by the more abundant glucocorticoids, corticosterone and cortisol.	Corticosterone	250-264	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	49-62
8691108-8	1996	In addition, ET-1-stimulated animals showed significant increases in aldosterone as well as corticosterone concentrations in plasma.	Corticosterone	92-106	endothelin 1	Rattus norvegicus	13-17
8635652-5	1996	All the strains investigated were susceptible to IL-1 beta-induced changes in body weight, food intake, temperature, and plasma glucagon and corticosterone.	Corticosterone	141-155	interleukin 1 beta	Rattus norvegicus	49-58
8809673-2	1996	In the first series of experiments, adrenalectomized (ADX) rats were injected with corticosterone one hour prior to decapitation (1-1000 micrograms/100 g body weight) after which 5HT1A induced hyperpolarizations were determined in vitro by means of intracellular recordings.	Corticosterone	83-97	5-hydroxytryptamine receptor 1A	Rattus norvegicus	179-184
8809673-8	1996	Altogether, this study presents further evidence that 5HT transmission in hippocampal CA1 area is modulated by differential steroid receptor activation as may occur under physiological circumstances due to different plasma concentrations of corticosterone.	Corticosterone	241-255	carbonic anhydrase 1	Rattus norvegicus	86-89
8627386-1	1996	We have shown previously that repeated laboratory restraint stress or daily corticosterone administration affects the structure of CA3 hippocampal neurons in rats.	Corticosterone	76-90	carbonic anhydrase 3	Rattus norvegicus	131-134
8813353-0	1996	Corticosterone promotes increased heme oxygenase-2 protein and transcript expression in the newborn rat brain.	Corticosterone	0-14	heme oxygenase 2	Rattus norvegicus	34-50
8813353-6	1996	Postparturition exposure to corticosterone resulted in a marked enhancement of HO-2 immunoreactivity in several neuronal populations, including, among others, the cerebellum, the hippocampal formation, and the oculomotor and red nuclei.	Corticosterone	28-42	heme oxygenase 2	Rattus norvegicus	79-83
8967481-2	1996	The cloned 11 beta HSD2 displayed Michaelis constant values for corticosterone and cortisol of 5.1 and 61 nM, respectively.	Corticosterone	64-78	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	11-23
8737679-2	1996	Recent evidence suggests corticosterone may play a role in the development of sensitization perhaps through the down-regulation of glucocorticoid receptor (GR).	Corticosterone	25-39	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	131-154
8737679-2	1996	Recent evidence suggests corticosterone may play a role in the development of sensitization perhaps through the down-regulation of glucocorticoid receptor (GR).	Corticosterone	25-39	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	156-158
9053060-1	1996	Corticotropin-releasing hormone administration into the neostriatum was shown to increase the level of corticosterone in the blood, as well as adrenaline and noradrenaline contents in the adrenal glands.	Corticosterone	103-117	corticotropin releasing hormone	Homo sapiens	0-31
8628267-0	1996	Regulation of the chicken ovalbumin gene by estrogen and corticosterone requires a novel DNA element that binds a labile protein, Chirp-1.	Corticosterone	57-71	ovalbumin (SERPINB14)	Gallus gallus	26-35
8621210-5	1996	ET-1 enhanced in a concentration-dependent manner aldosterone and corticosterone secretions of dispersed zona glomerulosa and zona fasciculata cells, respectively.	Corticosterone	66-80	endothelin 1	Rattus norvegicus	0-4
8780008-4	1996	In contrast, corticosterone exacerbated neuronal injury induced by glutamate, FeSO4, and A beta.	Corticosterone	13-27	amyloid beta precursor protein	Homo sapiens	89-95
8726241-7	1996	Adrenalectomy of A/J or CD-1 dams resulted in a reduction of endogenous corticosterone, but did not reduce the spontaneous incidence of cleft palate in the offspring.	Corticosterone	72-86	CD1 antigen complex	Mus musculus	24-28
8840131-3	1996	Amylin and adrenomedullin, two members of the CGRP family, induced a weak stimulation of corticosterone and aldosterone secretion from perifused frog adrenal slices.	Corticosterone	89-103	islet amyloid polypeptide	Homo sapiens	0-6
8840131-3	1996	Amylin and adrenomedullin, two members of the CGRP family, induced a weak stimulation of corticosterone and aldosterone secretion from perifused frog adrenal slices.	Corticosterone	89-103	adrenomedullin	Homo sapiens	11-25
8840131-3	1996	Amylin and adrenomedullin, two members of the CGRP family, induced a weak stimulation of corticosterone and aldosterone secretion from perifused frog adrenal slices.	Corticosterone	89-103	calcitonin related polypeptide alpha	Homo sapiens	46-50
8840131-6	1996	Concurrently, the type-2 CGRP receptor agonist [acetamidomethyl-Cys2,7]human CGRP ([Cys(ACM)2,7]human CGRP) provoked a dose-dependent stimulation of corticosterone and aldosterone secretion (EC50 = 1.6 x 10(-7) M).	Corticosterone	149-163	calcitonin related polypeptide alpha	Homo sapiens	25-29
8840131-6	1996	Concurrently, the type-2 CGRP receptor agonist [acetamidomethyl-Cys2,7]human CGRP ([Cys(ACM)2,7]human CGRP) provoked a dose-dependent stimulation of corticosterone and aldosterone secretion (EC50 = 1.6 x 10(-7) M).	Corticosterone	149-163	calcitonin related polypeptide alpha	Homo sapiens	77-81
8840131-6	1996	Concurrently, the type-2 CGRP receptor agonist [acetamidomethyl-Cys2,7]human CGRP ([Cys(ACM)2,7]human CGRP) provoked a dose-dependent stimulation of corticosterone and aldosterone secretion (EC50 = 1.6 x 10(-7) M).	Corticosterone	149-163	calcitonin related polypeptide alpha	Homo sapiens	77-81
8730750-21	1996	These data also show that the ability of rolipram to inhibit the local production of TNF alpha is dependent on the release of corticosterone from the adrenal glands.	Corticosterone	126-140	tumor necrosis factor	Mus musculus	85-94
8673146-1	1996	Previous work from our laboratory provided evidence for increased plasma corticosterone levels in mice transgenic for human and bovine growth hormone (GH).	Corticosterone	73-87	growth hormone	Mus musculus	135-149
8673146-9	1996	The results indicate that increased circulating levels of corticosterone in transgenic mice are not due to a potentiation of ACTH actions by GH or IGF-I, but rather to a chronic increase in plasma ACTH levels.	Corticosterone	58-72	pro-opiomelanocortin-alpha	Mus musculus	197-201
8673146-0	1996	Increased plasma corticosterone levels in bovine growth hormone (bGH) transgenic mice: effects of ACTH, GH and IGF-I on in vitro adrenal corticosterone production.	Corticosterone	17-31	growth hormone	Mus musculus	49-63
8739887-0	1996	Acute intracerebroventricular administration of neuropeptide Y stimulates corticosterone output and feeding but not insulin output in normal rats.	Corticosterone	74-88	neuropeptide Y	Rattus norvegicus	48-62
8738131-4	1996	However, treatment of the adrenalectomized animals with a low dose of corticosterone (3 micrograms/100 g bodyweight) resulted in an enhanced expression of the KAR1, KAR2 and GluR6 subunit mRNAs, when compared to the expression levels in the untreated rats or the sham operated controls.	Corticosterone	70-84	glutamate ionotropic receptor kainate type subunit 2	Rattus norvegicus	174-179
8738131-5	1996	Treatment with a high dose of corticosterone (1 mg/100 g bodyweight) yielded expression levels which were significantly lower than those observed in animals treated with a low corticosterone dose, for the KAR1, KAR2 and GluR7 subunit mRNAs; the levels did not differ from those in untreated rats or in the sham group.	Corticosterone	30-44	glutamate ionotropic receptor kainate type subunit 3	Rattus norvegicus	220-225
8738131-5	1996	Treatment with a high dose of corticosterone (1 mg/100 g bodyweight) yielded expression levels which were significantly lower than those observed in animals treated with a low corticosterone dose, for the KAR1, KAR2 and GluR7 subunit mRNAs; the levels did not differ from those in untreated rats or in the sham group.	Corticosterone	176-190	glutamate ionotropic receptor kainate type subunit 3	Rattus norvegicus	220-225
8738156-2	1996	The present study was undertaken to characterize the interactions of corticosterone (CORT) with ethanol effects on 45Ca2+ uptake in synaptosomes depolarized by high K+ (70 mM).	Corticosterone	69-83	cortistatin	Homo sapiens	85-89
8739887-13	1996	injection of a maximum dose of NPY had definite effects on plasma corticosterone concentrations and feeding, it favored neither the basal nor the substrate-induced insulin output.	Corticosterone	66-80	neuropeptide Y	Rattus norvegicus	31-34
8733012-3	1996	11 beta-HSD1 is NADPH-dependent and at its major site of action (the liver) is a reductase, converting cortisone to cortisol (11-dehydrocorticosterone to corticosterone in the rat).	Corticosterone	136-150	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	0-7
8733012-4	1996	11 beta-HSD2 is NAD-dependent, is present in tissues such as the kidney and placenta, and converts cortisol to cortisone (corticosterone to 11-dehydrocorticosterone in the rat).	Corticosterone	122-136	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	0-12
9389169-0	1996	[Bovine serum albumin-conjugated corticosterone inhibits the release of arginine vasopressin].	Corticosterone	33-47	albumin	Rattus norvegicus	14-21
9389169-0	1996	[Bovine serum albumin-conjugated corticosterone inhibits the release of arginine vasopressin].	Corticosterone	33-47	arginine vasopressin	Rattus norvegicus	81-92
9389169-2	1996	The effect of bovine serum albumin-conjugated corticosterone (B-BSA) on the AVP release was investigated.	Corticosterone	46-60	albumin	Rattus norvegicus	27-34
8604057-7	1996	Increases in NGF and bFGF mRNAs were also observed after administration of corticosterone and, albeit to a lesser extent, aldosterone, suggesting that the pituitary-adrenocortical axis plays an important role in the regulation of NGF and bFGF expression in the brain.	Corticosterone	75-89	fibroblast growth factor 2	Rattus norvegicus	21-25
8621378-2	1996	It has been demonstrated that exogenous human OB protein (leptin) treatment reduces food intake and weight gain, as well as insulin, glucose, and corticosterone levels in ob/ob mice.	Corticosterone	146-160	leptin	Homo sapiens	58-64
8634432-1	1996	Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1).	Corticosterone	94-108	ciliary neurotrophic factor	Mus musculus	0-27
8634432-1	1996	Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1).	Corticosterone	94-108	ciliary neurotrophic factor	Mus musculus	29-33
8634432-1	1996	Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1).	Corticosterone	94-108	interleukin 6	Mus musculus	39-52
8634432-1	1996	Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1).	Corticosterone	94-108	interleukin 6	Mus musculus	54-58
8634432-1	1996	Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1).	Corticosterone	94-108	interleukin 1 complex	Mus musculus	140-153
8634432-1	1996	Ciliary neurotrophic factor (CNTF) and interleukin-6 (IL-6) potentiate the elevation of serum corticosterone induced by suboptimal doses of interleukin-1 (IL-1).	Corticosterone	94-108	interleukin 1 complex	Mus musculus	155-159
8634432-3	1996	Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], interleukin-11 and cardiotrophin-1) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1.	Corticosterone	173-187	leukemia inhibitory factor	Mus musculus	43-69
8634432-3	1996	Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], interleukin-11 and cardiotrophin-1) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1.	Corticosterone	173-187	oncostatin M	Mus musculus	77-89
8634432-3	1996	Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], interleukin-11 and cardiotrophin-1) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1.	Corticosterone	173-187	interleukin 11	Mus musculus	97-111
8634432-3	1996	Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], interleukin-11 and cardiotrophin-1) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1.	Corticosterone	173-187	cardiotrophin 1	Mus musculus	116-131
8634432-3	1996	Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], interleukin-11 and cardiotrophin-1) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1.	Corticosterone	173-187	interleukin 6	Mus musculus	192-196
8634432-3	1996	Here, we report that four other cytokines (leukemia inhibitory factor [LIF], oncostatin M [OSM], interleukin-11 and cardiotrophin-1) also potentiated the elevation of serum corticosterone and IL-6 levels induced by IL-1.	Corticosterone	173-187	interleukin 1 complex	Mus musculus	215-219
8634432-6	1996	The potentiation of IL-1-induced serum corticosterone levels is not a consequence of the increased serum IL-6 observed after IL-1 administration.	Corticosterone	39-53	interleukin 1 complex	Mus musculus	20-24
8634432-7	1996	In fact, in IL-6 deficient mice, IL-1 increased serum corticosterone to a level comparable to that observed in wild-type mice.	Corticosterone	54-68	interleukin 6	Mus musculus	12-16
8634432-7	1996	In fact, in IL-6 deficient mice, IL-1 increased serum corticosterone to a level comparable to that observed in wild-type mice.	Corticosterone	54-68	interleukin 1 complex	Mus musculus	33-37
8833038-2	1996	CS treatment reduced the basal mRNA levels of IL-1 alpha and IL-1 beta, but elevated the mRNA levels of IL-6 in the hypothalamus and hippocampus as shown by RT-PCR.	Corticosterone	0-2	interleukin 1 alpha	Rattus norvegicus	46-56
8833038-2	1996	CS treatment reduced the basal mRNA levels of IL-1 alpha and IL-1 beta, but elevated the mRNA levels of IL-6 in the hypothalamus and hippocampus as shown by RT-PCR.	Corticosterone	0-2	interleukin 1 beta	Rattus norvegicus	61-70
8833038-2	1996	CS treatment reduced the basal mRNA levels of IL-1 alpha and IL-1 beta, but elevated the mRNA levels of IL-6 in the hypothalamus and hippocampus as shown by RT-PCR.	Corticosterone	0-2	interleukin 6	Rattus norvegicus	104-108
8833038-4	1996	IL-6 bioactivity in serum was not significantly changed by CS treatment, but increased 50 times upon injection of rhIL-1 beta.	Corticosterone	59-61	interleukin 6	Rattus norvegicus	0-4
8833038-5	1996	rhIL-1 beta caused a significantly lower induction of serum IL-6 levels in CS pretreated rats (9-fold).	Corticosterone	75-77	interleukin 6	Rattus norvegicus	60-64
8833038-7	1996	These results suggest that altered and clamped hypothalamic IL-1 alpha, IL-1 beta and IL-6 mRNA levels may be involved in the antipyretic effects of a pretreatment with high doses of CS and that these CS effects are rapidly reversible.	Corticosterone	183-185	interleukin 1 alpha	Rattus norvegicus	60-70
8833038-7	1996	These results suggest that altered and clamped hypothalamic IL-1 alpha, IL-1 beta and IL-6 mRNA levels may be involved in the antipyretic effects of a pretreatment with high doses of CS and that these CS effects are rapidly reversible.	Corticosterone	183-185	interleukin 1 beta	Rattus norvegicus	72-81
8833038-7	1996	These results suggest that altered and clamped hypothalamic IL-1 alpha, IL-1 beta and IL-6 mRNA levels may be involved in the antipyretic effects of a pretreatment with high doses of CS and that these CS effects are rapidly reversible.	Corticosterone	183-185	interleukin 6	Rattus norvegicus	86-90
8833038-7	1996	These results suggest that altered and clamped hypothalamic IL-1 alpha, IL-1 beta and IL-6 mRNA levels may be involved in the antipyretic effects of a pretreatment with high doses of CS and that these CS effects are rapidly reversible.	Corticosterone	201-203	interleukin 6	Rattus norvegicus	86-90
8603583-1	1996	In the rat, the enzyme 11beta-hydroxysteroid dehydrogenase 2 (11betaHSD2) converts the glucocorticoid corticosterone into receptor-inactive 11-dehydrocorticosterone, thereby allowing preferential access of aldosterone to mineralocorticoid receptors (MR).	Corticosterone	102-116	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	23-60
8603583-1	1996	In the rat, the enzyme 11beta-hydroxysteroid dehydrogenase 2 (11betaHSD2) converts the glucocorticoid corticosterone into receptor-inactive 11-dehydrocorticosterone, thereby allowing preferential access of aldosterone to mineralocorticoid receptors (MR).	Corticosterone	102-116	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	62-72
8743284-2	1996	and intracerebroventricular (i.c.v) administration of increasing doses of recombinant human IL-1 beta, TNF alpha and IL-6 on plasma corticosterone (B) levels in rats.	Corticosterone	132-146	interleukin 1 beta	Homo sapiens	92-101
8743284-2	1996	and intracerebroventricular (i.c.v) administration of increasing doses of recombinant human IL-1 beta, TNF alpha and IL-6 on plasma corticosterone (B) levels in rats.	Corticosterone	132-146	interleukin 6	Homo sapiens	117-121
8639467-4	1996	At 4 degrees C, the sensitivity to MMTS of the liganded-hMR complexes was dependent upon the nature of the ligands: agonists (aldosterone, corticosterone and cortisol) rendered the hMR resistant to MMTS, whereas antagonists (progesterone and RU26752) did not protect the receptor against MMTS inactivation.	Corticosterone	139-153	mannose receptor C-type 1	Homo sapiens	56-59
8639467-4	1996	At 4 degrees C, the sensitivity to MMTS of the liganded-hMR complexes was dependent upon the nature of the ligands: agonists (aldosterone, corticosterone and cortisol) rendered the hMR resistant to MMTS, whereas antagonists (progesterone and RU26752) did not protect the receptor against MMTS inactivation.	Corticosterone	139-153	mannose receptor C-type 1	Homo sapiens	181-184
8639469-6	1996	The non-peptidic NK-1 receptor antagonist RP 67580 significantly reduced the stimulatory effect of ranakinin on corticosterone and aldosterone secretion by 57 and 55%, respectively.	Corticosterone	112-126	tachykinin receptor 1	Homo sapiens	17-30
8677011-2	1996	Coadministration of IL-6 (100 ng/rat) with IL-1 (20 or 100 mg/ rat) resulted in synergistic stimulation of the HPA axis, as determined by increased plasma levels of ACTH and corticosterone (CORT) which were greater in rats that received both cytokines than in rats receiving either cytokine alone.	Corticosterone	174-188	interleukin 6	Rattus norvegicus	20-24
8783197-1	1996	Thermoregulatory and plasma corticosterone responses to peripheral LPS and TNF alpha were compared and correlated with brain FOS protein expression.	Corticosterone	28-42	tumor necrosis factor	Homo sapiens	75-84
8783197-2	1996	TNF alpha mimicked the corticosterone response evoked by LPS and the increase in FOS expression in the hypothalamic PVN.	Corticosterone	23-37	tumor necrosis factor	Homo sapiens	0-9
8848910-3	1996	We studied whether high-dose fentanyl may influence the IL-1 beta-induced alterations in plasma ACTH and corticosterone in rats.	Corticosterone	105-119	interleukin 1 beta	Rattus norvegicus	56-65
8964895-4	1996	Administration of SCF elevated adrenocorticotropin (ACTH), corticosterone and prolactin (PRL) plasma levels in a dose-dependent manner.	Corticosterone	59-73	KIT ligand	Rattus norvegicus	18-21
8964895-5	1996	Adrenocorticotropin and corticosterone secretions were maximal after injecting 10 micrograms SCF, while prolactin secretion only reached a maximum at a dose of 20 micrograms.	Corticosterone	24-38	KIT ligand	Rattus norvegicus	93-96
8568256-6	1996	Plasma corticosterone levels were increased by LPS at a time when maximal levels of plasma TNF-alpha were observed in both age groups, although the kinetics of hormone production and the magnitude of TNF-alpha release varied among the age groups.	Corticosterone	7-21	tumor necrosis factor	Mus musculus	91-100
8779944-1	1996	A circadian rhythm secretion of corticotropin-releasing hormone (CRH) is thought to regulate the circadian pattern of secretion of adrenocorticotropic hormone and corticosterone.	Corticosterone	163-177	corticotropin releasing hormone	Rattus norvegicus	32-63
8779944-1	1996	A circadian rhythm secretion of corticotropin-releasing hormone (CRH) is thought to regulate the circadian pattern of secretion of adrenocorticotropic hormone and corticosterone.	Corticosterone	163-177	corticotropin releasing hormone	Rattus norvegicus	65-68
8611140-1	1996	By inactivating potent glucocorticoid hormones (cortisol and corticosterone), 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) plays an important role in the placenta by controlling fetal exposure to maternal glucocorticoids, and in aldosterone target tissues by controlling ligand access to co-localized glucocorticoid and mineralocorticoid receptors.	Corticosterone	61-75	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	78-135
9011616-8	1996	Plasma concentration of corticosterone increased significantly after injection of IL-1 beta (10 micrograms kg-1).	Corticosterone	24-38	interleukin 1 beta	Rattus norvegicus	82-91
8699147-0	1996	Studies on the role of TRH and corticosterone in the regulation of prolactin and thyrotrophin secretion during lactation.	Corticosterone	31-45	prolactin	Rattus norvegicus	67-76
8611186-1	1996	11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) efficiently inactivates potent glucocorticoid hormones (cortisol and corticosterone), leaving aldosterone unmetabolized.	Corticosterone	128-142	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	0-57
8593800-1	1996	To study possible mechanisms controlling diurnal changes in corticosterone (CORT) levels, we tested the CORT responses to ACTH in the morning (AM) and evening (PM) in male Wistar and Sprague-Dawley rats.	Corticosterone	60-74	cortistatin	Rattus norvegicus	76-80
8778170-0	1996	Bicuculline enhances the corticosterone secretion induced by lipopolysaccharide and interleukin-1 alpha in male rats.	Corticosterone	25-39	interleukin 1 alpha	Rattus norvegicus	84-103
8778170-12	1996	The present study provides evidence that GABA is involved, at least in part, in the neuroendocrine regulation of LPS/interleukin-1a-induced corticosterone secretion via GABA-A receptor in rats.	Corticosterone	140-154	interleukin 1 alpha	Rattus norvegicus	117-131
8868260-0	1996	Corticosterone controls interleukin-1 beta expression and sickness behavior in the rat.	Corticosterone	0-14	interleukin 1 beta	Rattus norvegicus	24-42
8868260-7	1996	Administration of corticosterone 1 h before LPS lowered the splenic IL-1 beta mRNA content compared to LPS-treated adrenal-intact rats that did not receive corticosterone and inhibited fever and anorexia, whereas the glucocorticoid did not attenuate the endotoxin-induced suppression of locomotor activity.	Corticosterone	18-32	interleukin 1 beta	Rattus norvegicus	68-77
8868260-8	1996	Our data suggest that during inflammatory conditions body temperature, sickness behavior and the synthesis of IL-1 beta are controlled by corticosterone.	Corticosterone	138-152	interleukin 1 beta	Rattus norvegicus	110-119
8576180-8	1996	Consistent with this hormonal regulation, hepatic PPAR alpha mRNA and protein levels follow a diurnal rhythm, which parallels that of circulating corticosterone.	Corticosterone	146-160	peroxisome proliferator activated receptor alpha	Rattus norvegicus	50-60
8699147-10	1996	Hypothalamic proTRH mRNA increased twofold after 0.5 h of suckling, and then gradually returned to presuckling values after 6 h. Compared with sham-operated rats, corticosterone-substituted ADX rats with ten pups had increased plasma PRL and TSH, hypothalamic proTRH mRNA and pituitary TSH beta mRNA on day 15 of lactation.	Corticosterone	163-177	thyrotropin releasing hormone	Rattus norvegicus	13-19
8699147-10	1996	Hypothalamic proTRH mRNA increased twofold after 0.5 h of suckling, and then gradually returned to presuckling values after 6 h. Compared with sham-operated rats, corticosterone-substituted ADX rats with ten pups had increased plasma PRL and TSH, hypothalamic proTRH mRNA and pituitary TSH beta mRNA on day 15 of lactation.	Corticosterone	163-177	thyrotropin releasing hormone	Rattus norvegicus	260-266
8699147-10	1996	Hypothalamic proTRH mRNA increased twofold after 0.5 h of suckling, and then gradually returned to presuckling values after 6 h. Compared with sham-operated rats, corticosterone-substituted ADX rats with ten pups had increased plasma PRL and TSH, hypothalamic proTRH mRNA and pituitary TSH beta mRNA on day 15 of lactation.	Corticosterone	163-177	thyroid stimulating hormone subunit beta	Rattus norvegicus	286-294
8772501-3	1996	A rapid upsurge of serum corticosterone was observed during the first hour of isolation, occurring in parallel with a transient enhancement of ornithine decarboxylase (ODC) expression and followed by an increase in mucosal polyamine content.	Corticosterone	25-39	ornithine decarboxylase 1	Rattus norvegicus	168-171
8720501-3	1996	To this end, stress-induced c-fos expression was characterized in adrenalectomized (ADX) or adrenalectomized and corticosterone replaced (ADX/B) male rats.	Corticosterone	113-127	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	28-33
8769812-4	1996	We demonstrate that antisense oligodeoxynucleotides corresponding to the NH2-terminus and the translation start site of vasoactive intestinal peptide (VIP) mRNA infused into the suprachiasmatic region of rats temporarily abolishes the circadian rhythm of corticosterone secretion without influencing stress-related corticosterone secretion in the same animals.	Corticosterone	255-269	vasoactive intestinal peptide	Rattus norvegicus	151-154
8769812-4	1996	We demonstrate that antisense oligodeoxynucleotides corresponding to the NH2-terminus and the translation start site of vasoactive intestinal peptide (VIP) mRNA infused into the suprachiasmatic region of rats temporarily abolishes the circadian rhythm of corticosterone secretion without influencing stress-related corticosterone secretion in the same animals.	Corticosterone	315-329	vasoactive intestinal peptide	Rattus norvegicus	151-154
8883917-7	1996	By contrast with previous experiments is rats, the IL-1-induced increase in plasma corticosterone was not significantly altered by the 6-OHDA pretreatment in mice.	Corticosterone	83-97	interleukin 1 complex	Mus musculus	51-55
8788518-0	1996	Role of the hypothalamic paraventricular nucleus in 5-HT1A, 5-HT2A and 5-HT2C receptor-mediated oxytocin, prolactin and ACTH/corticosterone responses.	Corticosterone	125-139	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-58
8536643-2	1996	In this study, we analyzed the effects of CRF, vasopressin (AVP), dexamethasone (DEX), and corticosterone on the regulation of CRF receptor (CRF-R1) messenger RNA (mRNA) levels in cultured rat anterior pituitary cells.	Corticosterone	91-105	corticotropin releasing hormone receptor 1	Rattus norvegicus	141-147
8536639-3	1996	Dexamethasone (DM) augmented the abundance of pro-ANF mRNA signals in a dose-related manner with ED50 of 5 x 10(-12)M and Emax of 10(-10)M. This stimulation effect was mimicked by corticosterone but not by deoxycorticosterone.	Corticosterone	180-194	natriuretic peptide A	Rattus norvegicus	50-53
8557761-2	1996	IGFBP-1 was stimulated up to tenfold by dexamethasone and corticosterone, and this stimulation was abolished by RU486.	Corticosterone	58-72	insulin-like growth factor binding protein 1	Rattus norvegicus	0-7
8851896-6	1996	The CS concentration was increased by vibration independently of the pretreatment with AII.	Corticosterone	4-6	angiotensinogen	Rattus norvegicus	87-90
8568461-2	1996	We investigated, at the pre-diabetic stage, the effect of short-term administration of murine recombinant interleukin-1 alpha (mrIL-1 alpha) on the levels of glucose, insulin and corticosterone in the non-obese diabetic (NOD) mouse, a spontaneous model of type I diabetes.	Corticosterone	179-193	interleukin 1 alpha	Mus musculus	106-125
8932731-4	1996	These findings suggest that the reduced CBG levels might enhance the biological significance of existing glucocorticoid levels, beyond that assumed on the basis of plasma total corticosterone levels.	Corticosterone	177-191	serpin family A member 6	Rattus norvegicus	40-43
8839352-2	1996	The 4-kb RNA was increased 3-fold by treatment of adrenalectomized (ADX) rats with corticosterone (CORT).	Corticosterone	83-97	cortistatin	Rattus norvegicus	99-103
8613810-3	1996	Two isoforms exist: 11 beta-HSD1, a bidirectional NADPH-dependent enzyme, and 11 beta-HSD2, an NAD(+)-dependent exclusive 11 beta-dehydrogenase (corticosterone-inactivating enzyme).	Corticosterone	145-159	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	50-90
8778906-6	1996	In unanesthetized rats, plasma corticosterone increased shortly following IV or IP IL-1 beta administration, but the peak concentration following IV IL-1 beta was significantly earlier (around 1 h) than that following IP IL-1 beta (around 2 h).	Corticosterone	31-45	interleukin 1 beta	Rattus norvegicus	83-92
8719027-0	1996	Corticosterone alters 5-HT1A receptor-mediated hyperpolarization in area CA1 hippocampal pyramidal neurons.	Corticosterone	0-14	5-hydroxytryptamine receptor 1A	Rattus norvegicus	22-28
8719027-0	1996	Corticosterone alters 5-HT1A receptor-mediated hyperpolarization in area CA1 hippocampal pyramidal neurons.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	73-76
8719027-9	1996	Administration of high concentrations of CT in vitro to neurons from chronically treated ADX rats decreased the magnitude of the 5-HT1A receptor-mediated hyperpolarization.	Corticosterone	41-43	5-hydroxytryptamine receptor 1A	Rattus norvegicus	129-135
8778907-10	1996	Instead, the differences in available receptor levels may have been a function of plasma corticosteroid binding globulin (CBG) levels which regulate free corticosterone levels.	Corticosterone	154-168	serpin family A member 6	Rattus norvegicus	89-120
8778907-10	1996	Instead, the differences in available receptor levels may have been a function of plasma corticosteroid binding globulin (CBG) levels which regulate free corticosterone levels.	Corticosterone	154-168	serpin family A member 6	Rattus norvegicus	122-125
8713729-8	1996	Plasma corticosterone and aldosterone were increased in rat and rabbit adults after CRF and AVP; however, they remained unchanged in young rabbits and slightly increased only after CRF in young rats in which corticosterone remained at a very low concentration compared with that in adults.	Corticosterone	7-21	vasopressin-neurophysin 2-copeptin	Oryctolagus cuniculus	92-95
8597403-1	1995	The aim of this study is to investigate time-related changes in substance P (SP), beta-endorphin (BE), and corticosterone (CORT) levels due to DSIP aftereffects in the control and stress rats.	Corticosterone	107-121	cortistatin	Rattus norvegicus	123-127
8597419-3	1995	We further demonstrated that protection against lethal effects due to IL-1-beta or LPS could be produced by treating ADX rats with glucocorticoid in a quantity estimated to be equivalent to corticosterone secretion provoked during stress.	Corticosterone	190-204	interleukin 1 beta	Rattus norvegicus	70-79
8750957-0	1995	Membrane-mediated inhibition of corticosterone on the release of arginine vasopressin from rat hypothalamic slices.	Corticosterone	32-46	arginine vasopressin	Rattus norvegicus	74-85
8750967-1	1995	The present study investigates the effect of overexposure to high doses of the stress hormone corticosterone (CORT) on the electrophysiological changes produced in the hippocampus after local microinjection of KA.	Corticosterone	94-108	cortistatin	Mus musculus	110-114
8682934-7	1995	Elevation of vasopressin heteronuclear (hn) RNA in the medial parvicellular PVN was observed in both normal and adrenalectomized-corticosterone replaced rats as early as 30 minutes after stress initiation.	Corticosterone	129-143	arginine vasopressin	Rattus norvegicus	13-24
8682934-9	1995	In contrast, vasopressin hnRNA remained elevated 120 minutes post-restraint in adrenalectomized-corticosterone replaced rats, indicating that the glucocorticoid stress response acts to rapidly inhibit vasopressin transcription.	Corticosterone	96-110	arginine vasopressin	Rattus norvegicus	13-24
8682934-9	1995	In contrast, vasopressin hnRNA remained elevated 120 minutes post-restraint in adrenalectomized-corticosterone replaced rats, indicating that the glucocorticoid stress response acts to rapidly inhibit vasopressin transcription.	Corticosterone	96-110	arginine vasopressin	Rattus norvegicus	201-212
8608351-6	1995	In control animals with AA there was an increase in pro-opiomelanocortin (POMC) mRNA in the anterior pituitary and of plasma corticosterone, and a decrease in corticotrophin-releasing factor (CRF) mRNA.	Corticosterone	125-139	proopiomelanocortin	Rattus norvegicus	74-78
8536378-0	1995	Increased expression of proopiomelanocortin (POMC) mRNA in adrenal glands of mice undergoing graft-versus-host disease (GVHD): association with persistent elevated plasma corticosterone levels.	Corticosterone	171-185	pro-opiomelanocortin-alpha	Mus musculus	24-43
8536378-0	1995	Increased expression of proopiomelanocortin (POMC) mRNA in adrenal glands of mice undergoing graft-versus-host disease (GVHD): association with persistent elevated plasma corticosterone levels.	Corticosterone	171-185	pro-opiomelanocortin-alpha	Mus musculus	45-49
7588279-2	1995	Focus has been primarily on the acute stress-induced rise in glucocorticoids [corticosterone (CORT) in the rat].	Corticosterone	78-92	cortistatin	Rattus norvegicus	94-98
7588309-3	1995	This has been suggested to reflect the action of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), which catalyzes rapid inactivation of corticosterone to 11-dehydrocorticosterone (cortisol to cortisone).	Corticosterone	139-153	hydroxysteroid 11-beta dehydrogenase 2	Sus scrofa	49-85
7589849-0	1995	Corticosterone regulation of insulin-like growth factor I, IGF-binding proteins, and growth in streptozotocin-induced diabetic rats.	Corticosterone	0-14	insulin-like growth factor 1	Rattus norvegicus	29-57
7589849-1	1995	The experiments reported herein were conducted to determine how corticosterone regulates growth and plasma insulin-like growth factor (IGF) I and IGF-binding protein (IGFBP) concentrations in normal and streptozotocin (STZ)-induced diabetic rats.	Corticosterone	64-78	insulin-like growth factor 1	Rattus norvegicus	107-141
7589849-9	1995	In the 0 STZ Ax rats, plasma IGF-I and IGFBP-3 increased in proportion to the corticosterone implant dose, but IGFBP-1 was unaffected.	Corticosterone	78-92	insulin-like growth factor 1	Rattus norvegicus	29-34
7589849-10	1995	By contrast, IGF-I and IGFBP-3 were unaltered by corticosterone in the 30 STZ Ax rats, and IGFBP-1 increased in proportion with the dose of corticosterone.	Corticosterone	140-154	insulin-like growth factor binding protein 1	Rattus norvegicus	91-98
8751286-8	1995	A neural mechanism as splanchnic nerve activation in response to severe corticosterone deficiency is a reasonable hypothesis to explain the increase in adrenal NPY mRNA induced by metyrapone, although there are probably other, nonneural mechanisms by which metyrapone could stimulate adrenal NPY.	Corticosterone	72-86	neuropeptide Y	Rattus norvegicus	160-163
8844777-1	1996	Adrenomedullin (ADM), a vasodilatatory peptide contained in adrenal medulla, was found to induce a dose-dependent increase in aldosterone (ALDO) and corticosterone (B) release by the in situ perfused rat adrenal gland, along with a rise in the flow rate of the perfusion medium.	Corticosterone	149-163	adrenomedullin	Rattus norvegicus	0-14
8751286-8	1995	A neural mechanism as splanchnic nerve activation in response to severe corticosterone deficiency is a reasonable hypothesis to explain the increase in adrenal NPY mRNA induced by metyrapone, although there are probably other, nonneural mechanisms by which metyrapone could stimulate adrenal NPY.	Corticosterone	72-86	neuropeptide Y	Rattus norvegicus	292-295
8539261-13	1995	Administration of corticosterone (B; 25 micrograms/ml of 0.9% saline drinking water) to AxDb rats restored Db-like profiles of all IGFBPs.	Corticosterone	18-32	insulin-like growth factor binding protein 1	Rattus norvegicus	131-137
8597047-6	1995	Interestingly, IL-4 mRNA could not be detected in either treated or untreated ADX rats, indicating that expression of this gene is closely related to circulating levels of corticosterone.	Corticosterone	172-186	interleukin 4	Rattus norvegicus	15-19
8595193-2	1995	In order to test whether such an action could be observed in vivo, the distribution of neurotensin mRNA in the rat forebrain was analysed by in situ hybridization in rats treated chronically with corticosterone and in control animals.	Corticosterone	196-210	neurotensin	Rattus norvegicus	87-98
8595193-3	1995	Corticosterone treatment resulted in a selective induction of neurotensin mRNA in both the periventricular and rostral arcuate nuclei of the hypothalamus but not in the paraventricular nucleus of the hypothalamus or the hippocampal CA1-CA2 region.	Corticosterone	0-14	neurotensin	Rattus norvegicus	62-73
8577937-0	1995	VIP antagonist demonstrates differences in VIP- and PHI-mediated stimulation and inhibition of ACTH and corticosterone secretion in rats.	Corticosterone	104-118	vasoactive intestinal peptide	Rattus norvegicus	0-3
8579958-0	1995	Regulation of plasma osteocalcin by corticosterone and norepinephrine during restraint stress.	Corticosterone	36-50	bone gamma-carboxyglutamate protein	Rattus norvegicus	21-32
8579958-4	1995	We previously reported that mild mental stressors such as cage change or cold exposure decreased rat plasma OC by up to 40% within 1 h. A similar response was induced in a time- and dose-related manner by injection of physiological levels of corticosterone (CS), the active glucocorticoid in rats.	Corticosterone	242-256	bone gamma-carboxyglutamate protein	Rattus norvegicus	108-110
8579958-4	1995	We previously reported that mild mental stressors such as cage change or cold exposure decreased rat plasma OC by up to 40% within 1 h. A similar response was induced in a time- and dose-related manner by injection of physiological levels of corticosterone (CS), the active glucocorticoid in rats.	Corticosterone	258-260	bone gamma-carboxyglutamate protein	Rattus norvegicus	108-110
8579958-10	1995	The presence of both CS and NE, but not E, was required to return plasma OC concentrations to basal levels.	Corticosterone	21-23	bone gamma-carboxyglutamate protein	Rattus norvegicus	73-75
8579958-11	1995	This strongly suggests interaction of CS and NE to regulate plasma OC and its release from bone.	Corticosterone	38-40	bone gamma-carboxyglutamate protein	Rattus norvegicus	67-69
8593467-2	1995	In peritoneal macrophage exposed to corticosterone (2.9-87 microns) in vitro the interferon (IFN)-gamma (0.1 unit/ml)-induced Ia antigen expression was inhibited in a dose-dependent manner.	Corticosterone	36-50	interferon gamma	Mus musculus	81-103
8593467-6	1995	These result demonstrate that high levels of corticosterone increases the macrophage response to ifn-gamma on Ia antigen expression and that low levels of corticosterone decrease it.	Corticosterone	45-59	interferon gamma	Mus musculus	97-106
8593467-7	1995	Aconite extract and aconitine stimulate the response to IFN-gamma-activated expression of Ia antigen by macrophages which is caused by increasing the plasma corticosterone level.	Corticosterone	157-171	interferon gamma	Mus musculus	56-65
8602895-5	1995	The short-term rise in PNMT mRNA was accompanied by an increase in corticosterone and elevated levels of glucocorticoid receptor mRNA.	Corticosterone	67-81	phenylethanolamine-N-methyltransferase	Rattus norvegicus	23-27
8848097-8	1995	A further experiment examined the effect of antibodies against the neural cell adhesion molecule on the facilitatory action of corticosterone on long-term memory for the weak passive avoidance training.	Corticosterone	127-141	neural cell adhesion molecule 1	Gallus gallus	67-96
8848097-10	1995	Administration of the neural cell adhesion molecule antibodies during the late phase (5.5 h post-training) blocked the facilitatory action of corticosterone on long-term memory.	Corticosterone	142-156	neural cell adhesion molecule 1	Gallus gallus	22-51
7472494-10	1995	IL-1 beta-pretreated rats also showed increased ACTH and corticosterone responses to electric footshocks.	Corticosterone	57-71	interleukin 1 beta	Rattus norvegicus	0-9
7565753-1	1995	The CYP11B1 gene, which encodes steroid 11 beta-monooxygenase, which is responsible for the synthesis of cortisol and corticosterone, the major glucocorticoids in mammals, is expressed specifically in the zona fasciculata of the adrenal cortex.	Corticosterone	118-132	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	4-11
8574690-5	1995	Three weeks daily corticosterone treatment (10 mg/day) induced a marked increase of CB-ir exclusively in the CA1 pyramidal cell layer.	Corticosterone	18-32	carbonic anhydrase 1	Rattus norvegicus	109-112
8574690-6	1995	We conclude that (i) there is a close relationship between the loss of CB-immunoreactive cells in the DG and the neuronal degeneration in the dentate gyrus following ADX, and (ii) corticosterone appears to be involved in the regulation of calbindin-D28k in the CA1 pyramidal cell layer.	Corticosterone	180-194	carbonic anhydrase 1	Rattus norvegicus	261-264
8562666-7	1995	Consistent with previous work, stressed rats exhibited elevated basal plasma corticosterone (CORT) levels the first day poststressor.	Corticosterone	77-91	cortistatin	Rattus norvegicus	93-97
7561052-8	1995	Blood from stressed or adrenocorticotropic-releasing hormone-treated mice (in which CS levels are elevated) stimulated ex vivo with LPS produced significantly less TNF than blood from control mice.	Corticosterone	84-86	tumor necrosis factor	Mus musculus	164-167
8674838-6	1995	When transiently expressed in COS-7 cells the CYP11B3 converted deoxycorticosterone (DOC) to corticosterone and 18-hydroxydeoxycorticosterone, but not to 18-hydroxycorticosterone or aldosterone.	Corticosterone	69-83	cytochrome P450, family 11, subfamily b, polypeptide 3	Rattus norvegicus	46-53
7566151-6	1995	Hypothalamic neuropeptide Y stimulates food intake, decreases thermogenesis, and increases plasma insulin and corticosterone levels making it a potential target.	Corticosterone	110-124	neuropeptide Y	Mus musculus	13-27
7664672-3	1995	Systemic corticosterone (CORT) treatment, both daily injection (5 mg/rat.day) up to 14 days and pellet implant (200 mg) for 14 days, decreased CRH-R mRNA in the PVN and lateral and basolateral nucleus of the amygdala (BLA).	Corticosterone	9-23	cortistatin	Rattus norvegicus	25-29
7664672-3	1995	Systemic corticosterone (CORT) treatment, both daily injection (5 mg/rat.day) up to 14 days and pellet implant (200 mg) for 14 days, decreased CRH-R mRNA in the PVN and lateral and basolateral nucleus of the amygdala (BLA).	Corticosterone	9-23	corticotropin releasing hormone	Rattus norvegicus	143-146
7664672-4	1995	Corticosterone injection (10 mg/rat.day, for 7 days) decreased CRH-R mRNA in the AP.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	63-66
7561052-7	1995	TNF production by mouse blood stimulated in vitro with LPS was inhibited by addition of CS.	Corticosterone	88-90	tumor necrosis factor	Mus musculus	0-3
7561052-9	1995	Normal TNF production was restored by the addition of the GC receptor antagonist RU 38486, indicating a role for the elevated endogenous CS levels in the inhibition of TNF production.	Corticosterone	137-139	tumor necrosis factor	Mus musculus	168-171
7562985-6	1995	On the other hand, the plasma TNF-alpha levels were significantly elevated in C3H/HeN mice 1 h post-injection and the time course of plasma corticosterone concentration correlated well with the development of apoptosis.	Corticosterone	140-154	tumor necrosis factor	Mus musculus	30-39
8563722-0	1995	Bacterial lipopolysaccharide-induced changes in FOS protein expression in the rat brain: correlation with thermoregulatory changes and plasma corticosterone.	Corticosterone	142-156	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-51
8563722-1	1995	In the present study the regions of the brain showing an increase in the number of FOS protein stained cells 180 min following intravenous saline or bacterial lipopolysaccharide (LPS) treatment were investigated and correlated with changes in body temperature and plasma corticosterone levels.	Corticosterone	271-285	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-86
8563722-9	1995	Plasma corticosterone was unaffected by the lowest dose of LPS (0.35 micrograms), however the higher doses employed (3.5 and 50 micrograms) caused significant increases in plasma corticosterone which correlated with the increases in the number of FOS stained cells in the pPVN.	Corticosterone	179-193	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	247-250
8750205-0	1995	Calcitonin reduced corticosterone-induced muscle proteolysis.	Corticosterone	19-33	calcitonin-related polypeptide alpha	Rattus norvegicus	0-10
8544955-2	1995	CGRP administered into the lateral brain ventricle led to a dose-dependent increase in plasma corticosterone level, which could be blocked by pretreatment with CRF antiserum.	Corticosterone	94-108	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
7498325-6	1995	Moreover, sustained increase in plasma corticosterone by administration of adrenocorticotropic hormone was paralleled by an intense neutrophilia.	Corticosterone	39-53	pro-opiomelanocortin-alpha	Mus musculus	75-102
7581954-6	1995	The effect observed in the paraventricular TRH mRNA was correlated negatively with the serum corticosterone levels, a potential negative regulator of paraventricular TRH mRNA.	Corticosterone	93-107	thyrotropin releasing hormone	Homo sapiens	43-46
7581954-6	1995	The effect observed in the paraventricular TRH mRNA was correlated negatively with the serum corticosterone levels, a potential negative regulator of paraventricular TRH mRNA.	Corticosterone	93-107	thyrotropin releasing hormone	Homo sapiens	166-169
7649078-9	1995	Cells transfected with the 11 beta HSD-2 cDNA converted corticosterone into 11-dehydrocorticosterone.	Corticosterone	56-70	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	27-40
8527811-5	1995	AVP given ip was almost as potent as CRH in stimulating corticosterone secretion.	Corticosterone	56-70	corticotropin releasing hormone	Rattus norvegicus	37-40
8532191-0	1995	Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus.	Corticosterone	47-61	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	0-23
8532191-0	1995	Glucocorticoid receptor-mediated inhibition by corticosterone of 5-HT1A autoreceptor functioning in the rat dorsal raphe nucleus.	Corticosterone	47-61	5-hydroxytryptamine receptor 1A	Rattus norvegicus	65-71
8532191-8	1995	Complementary autoradiographic experiments showed that [3H]8-OH-DPAT specific binding to 5-HT1A sites in the dorsal raphe nucleus (and the hippocampus) was not significantly altered following adrenalectomy and exposure of brain stem slices to corticosterone.	Corticosterone	243-257	5-hydroxytryptamine receptor 1A	Rattus norvegicus	89-95
8532191-9	1995	These data suggest that GR are involved in the suppressive effects of high levels of corticosterone on the 5-HT1A receptor-dependent regulation of 5-HT neuronal activity in the rat dorsal raphe nucleus.	Corticosterone	85-99	5-hydroxytryptamine receptor 1A	Rattus norvegicus	107-113
8739199-10	1995	The concentrations of corticosterone in the serum of the OB rat were significantly reduced, but returned to control values following IL-2 treatment.	Corticosterone	22-36	interleukin 2	Rattus norvegicus	133-137
7638246-0	1995	Effects of corticosterone in vivo and in vitro on adrenocorticotropic hormone production by corticotropin releasing factor-stimulated leukocytes.	Corticosterone	11-25	corticotropin releasing hormone	Gallus gallus	92-122
7636240-2	1995	Surprisingly, we found that the principal glucocorticoid of the rat, corticosterone (CORT), potently enhanced anti-TCR-induced lymphocyte proliferation after 2 to 3 days in culture, followed by inhibited cell growth after 5 to 7 days.	Corticosterone	69-83	cortistatin	Rattus norvegicus	85-89
7628364-3	1995	We compared the stress responsiveness of sham-operated rats to that of adrenalectomized rats using a moderate dose of corticosterone (CORT) pellet replacement (ADX + CORT group).	Corticosterone	118-132	cortistatin	Rattus norvegicus	134-138
7622220-3	1995	In contrast to the differential effect of corticosterone on the antimycobacterial activity of the macrophages, corticosterone suppressed the production of tumor necrosis factor alpha and nitric oxide by macrophages from both Bcgr and Bcgs mice.	Corticosterone	111-125	tumor necrosis factor	Mus musculus	155-182
7593267-4	1995	When a differentiation mixture consisting of insulin, corticosterone and isobutylmethylxanthine was added to the serum-containing alpha-MEM, a proportion of the lean-mouse cells accumulated triglycerides and GPDH activity increased significantly, indicating differentiation.	Corticosterone	54-68	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	208-212
8546817-6	1995	The increase in both alpha 1 and beta 1 mRNA levels following aldosterone and corticosterone was completely abolished by treatment with ActD and DRB, while CHX did not affect this response.	Corticosterone	78-92	adrenoceptor alpha 1D	Homo sapiens	21-39
8704740-0	1995	A role for the mineralocorticoid receptor in a rapid and transient suppression of hippocampal 5-HT1A receptor mRNA by corticosterone.	Corticosterone	118-132	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	15-41
8704740-0	1995	A role for the mineralocorticoid receptor in a rapid and transient suppression of hippocampal 5-HT1A receptor mRNA by corticosterone.	Corticosterone	118-132	5-hydroxytryptamine receptor 1A	Rattus norvegicus	94-100
8704740-3	1995	Injection of corticosterone led to a significant dose-dependent and transient suppression of 5-HT1A receptor mRNA.	Corticosterone	13-27	5-hydroxytryptamine receptor 1A	Rattus norvegicus	93-99
8704740-4	1995	The effect of a low dose of corticosterone (50 micrograms/kg) could be blocked by RU 28318, a specific mineralocorticoid receptor antagonist, but not by RU 38486, a glucocorticoid antagonist.	Corticosterone	28-42	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	103-129
8704740-6	1995	These results point to a stringent regulation of hippocampal 5-HT1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor.	Corticosterone	81-95	5-hydroxytryptamine receptor 1A	Rattus norvegicus	61-67
8704740-6	1995	These results point to a stringent regulation of hippocampal 5-HT1A receptors by corticosterone that is predominantly mediated by the mineralocorticoid receptor.	Corticosterone	81-95	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	134-160
7622220-9	1995	The addition of corticosterone suppressed Nramp expression by macrophages from Bcgs mice.	Corticosterone	16-30	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	42-47
7476975-5	1995	As expected, plasma corticosterone levels were substantially decreased after POMC cell ablation.	Corticosterone	20-34	pro-opiomelanocortin-alpha	Mus musculus	77-81
7583298-0	1995	Effects of adrenalectomy and corticosterone replacement on glucocorticoid receptor levels in rat brain tissue: a comparison between western blotting and receptor binding assays.	Corticosterone	29-43	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	59-82
7623827-8	1995	In response to increases in adrenocorticotropin, NGFI-B (-/-) and wild-type mice demonstrated equivalent increases in serum corticosterone levels.	Corticosterone	124-138	nuclear receptor subfamily 4, group A, member 1	Mus musculus	49-55
7568448-0	1995	A possible involvement of VIP in feeding-induced secretion of ACTH and corticosterone in the rat.	Corticosterone	71-85	vasoactive intestinal peptide	Rattus norvegicus	26-29
7583298-4	1995	In contrast, adrenalectomized animals implanted with corticosterone pellets of varying concentrations displayed dose-dependent decreases in immunodetectable GR levels.	Corticosterone	53-67	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	157-159
7583298-7	1995	This discrepancy was most pronounced in adrenalectomized animals administered a bolus of corticosterone 1 h prior to sacrifice where a 60-70% reduction in receptor binding sites occurred, in sharp contrast to the 25-30% decrease in immunoreactive GR levels.	Corticosterone	89-103	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	247-249
7476024-1	1995	We have used reverse transcription followed by polymerase chain reaction amplification to investigate changes in expression of nerve growth factor (NGF) mRNA in immortalized hippocampal neurons after treatment with the glucocorticoids dexamethasone and corticosterone, the glucocorticoid antagonist RU38486, and the gonadal steroids progesterone and 17-beta oestradiol.	Corticosterone	253-267	nerve growth factor	Homo sapiens	127-146
7482289-1	1995	Pyramidal neurons in the rat hippocampal CA1 area contain mineralocorticoid (MRs) and glucocorticoid (GRs) receptors for corticosterone.	Corticosterone	121-135	carbonic anhydrase 1	Rattus norvegicus	41-44
7572238-3	1995	Administration of CS which led to an increase in plasma CS from 31 (controls) to 46 ng mL-1, reduced CL (per cell) by 31%.	Corticosterone	18-20	L1 cell adhesion molecule	Mus musculus	87-91
7631887-0	1995	Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice.	Corticosterone	0-14	interleukin 1 beta	Mus musculus	70-88
7631887-4	1995	Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS.	Corticosterone	33-47	interleukin 1 beta	Mus musculus	134-143
7631887-4	1995	Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS.	Corticosterone	33-47	interleukin 1 beta	Mus musculus	215-224
7631887-4	1995	Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS.	Corticosterone	33-47	toll-like receptor 4	Mus musculus	229-232
8720689-6	1995	Our findings suggested that actions of pineal melatonin in animals such as inhibition on serum corticosterone levels might be mediated by the potentiation of activities of hypothalamic neurons containing gamma-aminobutyric acid and aspartic acid or by the inhibition of the beta-endorphin and serotonin hypothalamic neurons.	Corticosterone	95-109	pro-opiomelanocortin-alpha	Mus musculus	274-288
7476024-1	1995	We have used reverse transcription followed by polymerase chain reaction amplification to investigate changes in expression of nerve growth factor (NGF) mRNA in immortalized hippocampal neurons after treatment with the glucocorticoids dexamethasone and corticosterone, the glucocorticoid antagonist RU38486, and the gonadal steroids progesterone and 17-beta oestradiol.	Corticosterone	253-267	nerve growth factor	Homo sapiens	148-151
7476024-2	1995	We found that NGF mRNA levels rise after application of either dexamethasone or corticosterone, and that this rise is prevented by the antagonist.	Corticosterone	80-94	nerve growth factor	Homo sapiens	14-17
7675174-9	1995	Corticosterone treatment decreased levels of glucocorticoid receptor immunoreactivity in the ventral tegmental area of Lewis rats, but not of Fischer rats.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	45-68
7789304-4	1995	Conversely, corticosterone and dexamethasone both resulted in profound reduction in corticotropin-releasing hormone mRNA in the PVN and a parallel reduction in pro-TRH mRNA (43.2% and 73.2% respectively; P &lt; 0.05).	Corticosterone	12-26	corticotropin releasing hormone	Rattus norvegicus	84-115
7789304-4	1995	Conversely, corticosterone and dexamethasone both resulted in profound reduction in corticotropin-releasing hormone mRNA in the PVN and a parallel reduction in pro-TRH mRNA (43.2% and 73.2% respectively; P &lt; 0.05).	Corticosterone	12-26	thyrotropin releasing hormone	Rattus norvegicus	160-167
7477894-5	1995	angiotensin II on corticosterone was also reduced.	Corticosterone	18-32	angiotensinogen	Rattus norvegicus	0-14
7675174-12	1995	We propose that corticosterone administration down-regulates the glucocorticoid receptor in the ventral tegmental area of Lewis rats, and thereby prevents other adaptations to corticosterone treatment, while in the ventral tegmental area of Fischer rats the lack of glucocorticoid receptor down-regulation and the high basal levels of cyclic AMP response element binding protein could facilitate the transcriptional, biochemical and behavioral actions of glucocorticoids.	Corticosterone	16-30	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	65-88
7675174-12	1995	We propose that corticosterone administration down-regulates the glucocorticoid receptor in the ventral tegmental area of Lewis rats, and thereby prevents other adaptations to corticosterone treatment, while in the ventral tegmental area of Fischer rats the lack of glucocorticoid receptor down-regulation and the high basal levels of cyclic AMP response element binding protein could facilitate the transcriptional, biochemical and behavioral actions of glucocorticoids.	Corticosterone	16-30	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	266-289
7675308-1	1995	Prolonged maternal deprivation during early infancy increases basal- and stress-induced corticosterone (CORT) levels, but the underlying mechanism is not clear.	Corticosterone	88-102	cortistatin	Rattus norvegicus	104-108
8529123-2	1995	We previously reported that CNTF augments the levels of corticosterone (CS) and of IL-6 induced by IL-1 and induces the production of the acute-phase protein serum amyloid A (SAA).	Corticosterone	56-70	ciliary neurotrophic factor	Mus musculus	28-32
8529123-2	1995	We previously reported that CNTF augments the levels of corticosterone (CS) and of IL-6 induced by IL-1 and induces the production of the acute-phase protein serum amyloid A (SAA).	Corticosterone	72-74	ciliary neurotrophic factor	Mus musculus	28-32
7626473-2	1995	Due to the difference in affinity of the two receptor types for corticosterone and variations in endogenous steroid levels, occupation of the receptors will range between a situation of predominant mineralocorticoid receptor activation and conditions where both receptor types are occupied.	Corticosterone	64-78	nuclear receptor subfamily 3 group C member 2	Homo sapiens	198-224
7750492-2	1995	Compared with infusion of vehicle, the CRH treatment produced a sustained overactivity of the HPA axis, as evidenced by elevated plasma ACTH and corticosterone levels, increased anterior pituitary POMC messenger RNA (mRNA) expression, and adrenal enlargement.	Corticosterone	145-159	corticotropin releasing hormone	Rattus norvegicus	39-42
7791083-0	1995	Modulation of the 5-hydroxytryptamine4 receptor-mediated response by short-term and long-term administration of corticosterone in rat CA1 hippocampal pyramidal neurons.	Corticosterone	112-126	carbonic anhydrase 1	Rattus norvegicus	134-137
7791083-1	1995	Corticosterone (CT) treatment decreases the magnitude of the 5-hydroxytryptamine (5-HT)1A receptor-mediated hyperpolarization in rat CA1 hippocampal pyramidal neurons.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	133-136
7791083-1	1995	Corticosterone (CT) treatment decreases the magnitude of the 5-hydroxytryptamine (5-HT)1A receptor-mediated hyperpolarization in rat CA1 hippocampal pyramidal neurons.	Corticosterone	16-18	carbonic anhydrase 1	Rattus norvegicus	133-136
7779756-5	1995	CYP11B1 transfected cells converted DOC into corticosterone, 18-OH-DOC and small amounts of 18-OH-corticosterone, in a time and concentration dependent manner.	Corticosterone	45-59	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	0-7
7779756-8	1995	CYP11B2 transfected cells converted DOC into corticosterone, 18-OH-corticosterone, aldosterone and small amounts of 18-OH-DOC in a time and concentration dependent manner.	Corticosterone	45-59	cytochrome P450, family 11, subfamily b, polypeptide 2	Mus musculus	0-7
7644021-8	1995	In aged rats, basal plasma corticosterone levels, which were significantly higher than in young animals, correlated negatively with spatial memory, while hippocampal glucocorticoid receptor mRNA expression correlated negatively with plasma corticosterone levels and positively with spatial memory.	Corticosterone	240-254	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	166-189
7644021-10	1995	Our data support the notion that corticosterone exerts a concentration-dependent biphasic influence, via selective activation of hippocampal mineralocorticoid and glucocorticoid receptor, on spatial memory.	Corticosterone	33-47	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	163-186
7651620-3	1995	Adrenalectomized rats displayed an enhanced number of Fos-positive neurons within the caudal-most portions of trigeminal subnucleus caudalis compared to that seen in adrenal-intact animals, an effect reversed by a single acute injection of corticosterone (1 mg/kg, i.p.)	Corticosterone	240-254	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-57
7651754-5	1995	In the present study we tested the 30- and 120-min effect of intraperitoneally administered 0.5 and 100 ng/g body weight IL-1 beta on the plasma immunoreactive (ir) ACTH, beta E, and corticosterone (CS) levels in the 10-d-old (infant) and 30-d-old (prepubertal) rat.	Corticosterone	183-197	interleukin 1 beta	Homo sapiens	121-130
7556516-16	1995	The elevated GFAP levels of transgenic mice may reflect increased neural damage due to accelerated aging processes or damage associated with high circulating levels of bGH or corticosterone.	Corticosterone	175-189	glial fibrillary acidic protein	Mus musculus	13-17
7570340-0	1995	Chronic corticosterone treatment maintains synaptic activity of CA1 hippocampal pyramidal cells: acute high corticosterone administration increases action potential number.	Corticosterone	8-22	carbonic anhydrase 1	Rattus norvegicus	64-67
7564566-0	1995	Developmental expression and corticosterone inhibition of adenosine deaminase activity in different tissues of mice.	Corticosterone	29-43	adenosine deaminase	Mus musculus	58-77
7564566-1	1995	The activity expression and corticosterone inhibition of adenosine deaminase (ADA) were studied in the spleen, stomach, and liver of mice at various postnatal ages.	Corticosterone	28-42	adenosine deaminase	Mus musculus	57-76
7564566-5	1995	Corticosterone administration brings a marked inhibition in the activity of ADA at all ages studied in the spleen and stomach whereas it inhibits the liver ADA only at 30 and 60 days postnatal age.	Corticosterone	0-14	adenosine deaminase	Mus musculus	76-79
7564566-5	1995	Corticosterone administration brings a marked inhibition in the activity of ADA at all ages studied in the spleen and stomach whereas it inhibits the liver ADA only at 30 and 60 days postnatal age.	Corticosterone	0-14	adenosine deaminase	Mus musculus	156-159
7564566-6	1995	These findings suggest an age- and tissue-specific expression of ADA activity and also indicate corticosterone as an inhibitory regulator of this enzyme.	Corticosterone	96-110	adenosine deaminase	Mus musculus	65-68
7720656-0	1995	Transcriptional regulation of glial fibrillary acidic protein by corticosterone in rat astrocytes in vitro is influenced by the duration of time in culture and by astrocyte-neuron interactions.	Corticosterone	65-79	glial fibrillary acidic protein	Rattus norvegicus	30-61
7720656-3	1995	Corticosterone (CORT) increased GFAP messenger RNA, protein, and transcription rates in cultured primary neonatal astrocytes, responses opposite the GFAP responses to CORT in vivo.	Corticosterone	0-14	cortistatin	Rattus norvegicus	16-20
7720656-3	1995	Corticosterone (CORT) increased GFAP messenger RNA, protein, and transcription rates in cultured primary neonatal astrocytes, responses opposite the GFAP responses to CORT in vivo.	Corticosterone	0-14	glial fibrillary acidic protein	Rattus norvegicus	32-36
7720656-3	1995	Corticosterone (CORT) increased GFAP messenger RNA, protein, and transcription rates in cultured primary neonatal astrocytes, responses opposite the GFAP responses to CORT in vivo.	Corticosterone	0-14	glial fibrillary acidic protein	Rattus norvegicus	149-153
7720656-3	1995	Corticosterone (CORT) increased GFAP messenger RNA, protein, and transcription rates in cultured primary neonatal astrocytes, responses opposite the GFAP responses to CORT in vivo.	Corticosterone	0-14	cortistatin	Rattus norvegicus	167-171
7720656-4	1995	The direction of GFAP regulation by corticosterone in vitro is reversed by coculture with neurons or by extended culture for 3 months.	Corticosterone	36-50	glial fibrillary acidic protein	Rattus norvegicus	17-21
7665003-0	1995	Possible involvement of prostaglandins in increases in rat plasma adrenocorticotropic hormone and corticosterone levels induced by radiation and interleukin-1 alpha alone or combined.	Corticosterone	98-112	interleukin 1 alpha	Rattus norvegicus	145-164
7594229-0	1995	Changes in glucocorticoid receptor immunoreactivity after adrenalectomy and corticosterone treatment in the rat testis.	Corticosterone	76-90	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	11-34
7649895-3	1995	In the intact glomerulosa cell, this sensitivity is located in the late pathway step catalyzed by conversion of corticosterone to aldosterone (P-450aldo), whereas the early pathway catalyzed by conversion of cholesterol to pregnenolone (P-450scc) is not inhibited until PO2 is very low.	Corticosterone	112-126	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	237-245
7594229-8	1995	On the other hand, adrenalectomy or repeated corticosterone treatment seem to affect GR similarly in all positive cells without changing significantly the proportion of GR IR in the different testicular compartments.	Corticosterone	45-59	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	85-87
7623287-4	1995	Corticosterone differentially regulated the levels of CRH and NT/N but not pENK mRNA.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	54-57
7623287-4	1995	Corticosterone differentially regulated the levels of CRH and NT/N but not pENK mRNA.	Corticosterone	0-14	neurotensin	Rattus norvegicus	62-66
7623287-10	1995	CRH mRNA in both the central nucleus of the amygdala and PVH, and NT/N mRNA in the central nucleus of the amygdala were most sensitive to plasma corticosterone concentrations of less than 120 ng ml-1, i.e. those seen away from the peak of the diurnal rhythm.	Corticosterone	145-159	neurotensin	Rattus norvegicus	66-70
7623287-11	1995	In adrenalectomized animals CRH mRNA in both the central nucleus of the amygdala and PVH could be set at levels usually seen in intact animals by the same plasma concentration of corticosterone.	Corticosterone	179-193	corticotropin releasing hormone	Rattus norvegicus	28-31
7623287-17	1995	Aldosterone also blunted the dose-response effects of corticosterone on CRH and NT/N mRNA levels in the central nucleus of the amygdala, but not in the PVH.	Corticosterone	54-68	corticotropin releasing hormone	Rattus norvegicus	72-75
7623287-17	1995	Aldosterone also blunted the dose-response effects of corticosterone on CRH and NT/N mRNA levels in the central nucleus of the amygdala, but not in the PVH.	Corticosterone	54-68	neurotensin	Rattus norvegicus	80-84
7620889-8	1995	However, corticosterone inhibited CRH-induced cAMP production in anterior pituitary cells.	Corticosterone	9-23	corticotropin releasing hormone	Rattus norvegicus	34-37
7623287-0	1995	Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone.	Corticosterone	101-115	pyroglutamylated RFamide peptide	Rattus norvegicus	30-42
7620889-8	1995	However, corticosterone inhibited CRH-induced cAMP production in anterior pituitary cells.	Corticosterone	9-23	cathelicidin antimicrobial peptide	Rattus norvegicus	46-50
7895695-0	1995	11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat.	Corticosterone	165-179	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	14-21
7733399-3	1995	Using an isolated perfused rat liver (IPRL) preparation, we have shown that the liver is an important source of circulating cytokines in response to lipopolysaccharide (LPS) and that corticosterone dose dependently influenced LPS-induced production of tumor necrosis factor (TNF) and interleukin-6 (IL-6).	Corticosterone	183-197	tumor necrosis factor-like	Rattus norvegicus	252-273
7733399-3	1995	Using an isolated perfused rat liver (IPRL) preparation, we have shown that the liver is an important source of circulating cytokines in response to lipopolysaccharide (LPS) and that corticosterone dose dependently influenced LPS-induced production of tumor necrosis factor (TNF) and interleukin-6 (IL-6).	Corticosterone	183-197	tumor necrosis factor-like	Rattus norvegicus	275-278
7733399-3	1995	Using an isolated perfused rat liver (IPRL) preparation, we have shown that the liver is an important source of circulating cytokines in response to lipopolysaccharide (LPS) and that corticosterone dose dependently influenced LPS-induced production of tumor necrosis factor (TNF) and interleukin-6 (IL-6).	Corticosterone	183-197	interleukin 6	Rattus norvegicus	284-297
7733399-3	1995	Using an isolated perfused rat liver (IPRL) preparation, we have shown that the liver is an important source of circulating cytokines in response to lipopolysaccharide (LPS) and that corticosterone dose dependently influenced LPS-induced production of tumor necrosis factor (TNF) and interleukin-6 (IL-6).	Corticosterone	183-197	interleukin 6	Rattus norvegicus	299-303
7895695-0	1995	11 alpha- and 11 beta-hydroxyprogesterone, potent inhibitors of 11 beta-hydroxysteroid dehydrogenase (isoforms 1 and 2), confer marked mineralocorticoid activity on corticosterone in the ADX rat.	Corticosterone	165-179	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	64-71
7781965-15	1995	Moreover, with Na+ restriction, maximal aldosterone production of the HDAC in response to AII peptides and K+ was increased over that of the control HDAC to a greater extent than was maximal aldosterone production in response to ACTH and that supported by corticosterone (% enhancement over control was as follows: AII peptides, 502%; K+, 668%; ACTH, 273%; corticosterone, 183%).	Corticosterone	256-270	histone deacetylase 9	Homo sapiens	70-74
7534336-0	1995	Corticosterone has a permissive effect on expression of heme oxygenase-1 in CA1-CA3 neurons of hippocampus in thermal-stressed rats.	Corticosterone	0-14	heme oxygenase 1	Rattus norvegicus	56-72
7534336-0	1995	Corticosterone has a permissive effect on expression of heme oxygenase-1 in CA1-CA3 neurons of hippocampus in thermal-stressed rats.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	76-79
7534336-0	1995	Corticosterone has a permissive effect on expression of heme oxygenase-1 in CA1-CA3 neurons of hippocampus in thermal-stressed rats.	Corticosterone	0-14	carbonic anhydrase 3	Rattus norvegicus	80-83
7534336-3	1995	In rats chronically treated with corticosterone, we examined expression of HO-1 and its response to thermal stress in the hippocampus.	Corticosterone	33-47	heme oxygenase 1	Rattus norvegicus	75-79
7534336-7	1995	HO-1 is essentially undetectable in this area when rats are exposed to chronic corticosterone alone or thermal stress by itself, or in control rats.	Corticosterone	79-93	heme oxygenase 1	Rattus norvegicus	0-4
7781965-15	1995	Moreover, with Na+ restriction, maximal aldosterone production of the HDAC in response to AII peptides and K+ was increased over that of the control HDAC to a greater extent than was maximal aldosterone production in response to ACTH and that supported by corticosterone (% enhancement over control was as follows: AII peptides, 502%; K+, 668%; ACTH, 273%; corticosterone, 183%).	Corticosterone	357-371	histone deacetylase 9	Homo sapiens	70-74
7647767-0	1995	Effects of monoclonal antibodies to specific epitopes of rat interleukin-1 beta (IL-1 beta) on IL-1 beta-induced ACTH, corticosterone and IL-6 responses in rats.	Corticosterone	119-133	interleukin 1 beta	Rattus norvegicus	95-104
7777608-2	1995	Furthermore, administration of exogenous corticosterone (CORT) restores behavioral inhibition in ADX pups.	Corticosterone	41-55	cortistatin	Rattus norvegicus	57-61
7772647-2	1995	Subordinate rats had elevated basal corticosterone (CORT) levels relative to dominants and individually housed controls.	Corticosterone	36-50	cortistatin	Rattus norvegicus	52-56
7770636-3	1995	Using isolated rat adrenal fasciculata-reticularis and glomerulosa cell bioassays, guinea pig ACTH was found to have similar activity to that of human ACTH with respect to corticosterone- and aldosterone-stimulating activity, in terms of maximal steroid output but was slightly more potent in terms of the concentration which elicited half-maximal steroid secretion.	Corticosterone	172-186	proopiomelanocortin	Homo sapiens	94-98
7652597-4	1995	(2) Corticosterone (B) inhibited AVP release within 20 min in a dose-dependent manner from 10(-7) to 10(-4) mol/L.	Corticosterone	4-18	arginine vasopressin	Rattus norvegicus	33-36
7893157-6	1995	In contrast, corticosterone, the product of P450c11, increased the rate of futile NADPH oxidation by the P450c11 system.	Corticosterone	13-27	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	44-51
7893157-6	1995	In contrast, corticosterone, the product of P450c11, increased the rate of futile NADPH oxidation by the P450c11 system.	Corticosterone	13-27	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	105-112
7900913-0	1995	Role of corticosterone in TNF and IL-6 production in isolated perfused rat liver.	Corticosterone	8-22	tumor necrosis factor-like	Rattus norvegicus	26-29
7900913-0	1995	Role of corticosterone in TNF and IL-6 production in isolated perfused rat liver.	Corticosterone	8-22	interleukin 6	Rattus norvegicus	34-38
7900913-1	1995	Using an isolated perfused rat liver (IPRL) preparation, we assessed whether corticosterone may contribute to the rise in tumor necrosis factor (TNF) and interleukin-6 (IL-6) in rats after injection with lipopolysaccharide (LPS) or exposure to psychological stress.	Corticosterone	77-91	tumor necrosis factor-like	Rattus norvegicus	122-143
7900913-1	1995	Using an isolated perfused rat liver (IPRL) preparation, we assessed whether corticosterone may contribute to the rise in tumor necrosis factor (TNF) and interleukin-6 (IL-6) in rats after injection with lipopolysaccharide (LPS) or exposure to psychological stress.	Corticosterone	77-91	tumor necrosis factor-like	Rattus norvegicus	145-148
7900913-1	1995	Using an isolated perfused rat liver (IPRL) preparation, we assessed whether corticosterone may contribute to the rise in tumor necrosis factor (TNF) and interleukin-6 (IL-6) in rats after injection with lipopolysaccharide (LPS) or exposure to psychological stress.	Corticosterone	77-91	interleukin 6	Rattus norvegicus	154-167
7900913-1	1995	Using an isolated perfused rat liver (IPRL) preparation, we assessed whether corticosterone may contribute to the rise in tumor necrosis factor (TNF) and interleukin-6 (IL-6) in rats after injection with lipopolysaccharide (LPS) or exposure to psychological stress.	Corticosterone	77-91	interleukin 6	Rattus norvegicus	169-173
7900913-4	1995	Intravenous infusion of corticosterone at nonstressed (35 ng/ml) and stressed levels (350 ng/ml) increased TNF and/or IL-6 release.	Corticosterone	24-38	tumor necrosis factor-like	Rattus norvegicus	107-110
7900913-4	1995	Intravenous infusion of corticosterone at nonstressed (35 ng/ml) and stressed levels (350 ng/ml) increased TNF and/or IL-6 release.	Corticosterone	24-38	interleukin 6	Rattus norvegicus	118-122
7900913-8	1995	In addition, although in vitro data generally support the hypothesis that corticosterone suppresses the production of cytokines, our in situ data support the hypothesis that physiological levels of corticosterone cause an increase in TNF and IL-6.	Corticosterone	198-212	tumor necrosis factor-like	Rattus norvegicus	234-237
7900913-8	1995	In addition, although in vitro data generally support the hypothesis that corticosterone suppresses the production of cytokines, our in situ data support the hypothesis that physiological levels of corticosterone cause an increase in TNF and IL-6.	Corticosterone	198-212	interleukin 6	Rattus norvegicus	242-246
7891134-7	1995	Corticosterone negative feedback may have contributed in part to the stress-induced decreases in BDNF mRNA levels, but stress still decreased BDNF in the dentate gyrus in adrenalectomized rats suggesting that additional components of the stress response must also contribute to the observed changes in BDNF.	Corticosterone	0-14	brain-derived neurotrophic factor	Rattus norvegicus	97-101
7891134-8	1995	However, corticosterone-mediated increases in NT-3 mRNA expression appeared to be primarily responsible for the effects of stress on NT-3.	Corticosterone	9-23	neurotrophin 3	Rattus norvegicus	46-50
7891134-8	1995	However, corticosterone-mediated increases in NT-3 mRNA expression appeared to be primarily responsible for the effects of stress on NT-3.	Corticosterone	9-23	neurotrophin 3	Rattus norvegicus	133-137
7791960-0	1995	Involvement of vasopressin and corticotropin-releasing hormone in VIP- and PHI-induced secretion of ACTH and corticosterone.	Corticosterone	109-123	arginine vasopressin	Homo sapiens	15-26
7791960-0	1995	Involvement of vasopressin and corticotropin-releasing hormone in VIP- and PHI-induced secretion of ACTH and corticosterone.	Corticosterone	109-123	corticotropin releasing hormone	Homo sapiens	31-62
7791960-0	1995	Involvement of vasopressin and corticotropin-releasing hormone in VIP- and PHI-induced secretion of ACTH and corticosterone.	Corticosterone	109-123	vasoactive intestinal peptide	Homo sapiens	66-69
7753883-7	1995	Nutritional deprivation during lactation affected production of CBP that effectively reduced the biological activity of corticosterone in circulation.	Corticosterone	120-134	CREB binding protein	Rattus norvegicus	64-67
7871163-7	1995	The ACTH response may be inhibited by elevated corticosterone levels after whole-body irradiation, or by other radiation-induced effects on the pituitary gland and hypothalamus.	Corticosterone	47-61	proopiomelanocortin	Homo sapiens	4-8
9001439-6	1995	Pre-immobilization corticosterone (CORT) levels were similar in both age groups; immobilization produced a dramatic increase in CORT in both groups; however, the increase was smaller in the old rats, although this did not reach statistical significance (P &lt; 0.06).	Corticosterone	19-33	cortistatin	Rattus norvegicus	35-39
7771651-0	1995	Altered ACTH and corticosterone responses to interleukin-1 beta in male rats exposed to an alcohol diet: possible role of vasopressin and testosterone.	Corticosterone	17-31	interleukin 1 beta	Rattus norvegicus	45-63
7771651-7	1995	In contrast, E rats released as much corticosterone as C rats in response to IL-1 beta, but significantly (p &lt; 0.05) more following administration of endotoxin (lipopolysaccharide).	Corticosterone	37-51	interleukin 1 beta	Rattus norvegicus	77-86
7588370-1	1995	CYP17 is not expressed in adult mouse adrenal glands but is expressed in a subset of fetal adrenocortical cells, indicating the potential to produce both corticosterone and cortisol during murine embryogenesis.	Corticosterone	154-168	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	0-5
7588387-4	1995	Dose-dependent increases (P &lt; 0.05) in corticosterone concentration were observed when primary adrenal cells were incubated with different doses (10(-10) to 10(-8) M) of IL-1 alpha.	Corticosterone	42-56	interleukin 1 alpha	Rattus norvegicus	173-183
7588387-5	1995	IL-1 alpha and IL-1 beta elevated corticosterone release after a 24 hr incubation period.	Corticosterone	34-48	interleukin 1 alpha	Rattus norvegicus	0-10
7588387-5	1995	IL-1 alpha and IL-1 beta elevated corticosterone release after a 24 hr incubation period.	Corticosterone	34-48	interleukin 1 beta	Rattus norvegicus	15-24
7588387-13	1995	Although IL-1 alpha significantly increased (P &lt; 0.05) prostaglandin E2 (PGE2) levels from primary adrenal cells, the presence of the cyclooxygenase inhibitor, indomethacin (10 microM) significantly inhibited IL-1 alpha-induced PGE2 secretion without altering the effect of IL-1 alpha on corticosterone release.	Corticosterone	291-305	interleukin 1 alpha	Rattus norvegicus	9-19
7588393-3	1995	P450c21 can 21-hydroxylate 17 alpha-hydroxyprogesterone to yield cortisol but also converts progesterone to corticosterone.	Corticosterone	108-122	steroid 21-hydroxylase	Ovis aries	0-7
7780034-0	1995	Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.	Corticosterone	117-131	ciliary neurotrophic factor	Mus musculus	0-27
7780034-0	1995	Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.	Corticosterone	117-131	ciliary neurotrophic factor	Mus musculus	29-33
7780034-0	1995	Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice.	Corticosterone	117-131	interleukin 1 complex	Mus musculus	104-108
7780034-2	1995	We studied the effect of CNTF, alone or in association with IL-1, on levels of corticosterone (CS), glucose, serum amyloid A (SAA), and IL-6.	Corticosterone	79-93	ciliary neurotrophic factor	Mus musculus	25-29
7780034-4	1995	A single intravenous injection of CNTF induced hypoglycaemia and SAA and potentiated IL-1-induced CS and IL-6.	Corticosterone	98-100	ciliary neurotrophic factor	Mus musculus	34-38
7780034-4	1995	A single intravenous injection of CNTF induced hypoglycaemia and SAA and potentiated IL-1-induced CS and IL-6.	Corticosterone	98-100	interleukin 1 complex	Mus musculus	85-89
7530648-4	1995	After 24 h of treatment with corticosterone, these cells displayed a concentration-dependent decrease in adhesion to type I collagen and fibronectin.	Corticosterone	29-43	fibronectin 1	Rattus norvegicus	137-148
7530648-6	1995	With 100 nM corticosterone treatment for 24 h, inhibition of the adhesion of ROS 17/2.8 cells and primary osteoblasts to fibronectin was 75 +/- 10% and 50 +/- 8%, and inhibition of adhesion to collagen was 31 +/- 10% and 65 +/- 5%, respectively.	Corticosterone	12-26	fibronectin 1	Rattus norvegicus	121-132
7852500-1	1995	Corticosterone methyloxidase type I (CMO-I) deficiency is an autosomal recessively inherited disorder causing congenital hypoaldosteronism due to defects in aldosterone synthase (P450aldo), the enzyme that converts 11-deoxycorticosterone to corticosterone, 18-hydroxycorticosterone, and aldosterone.	Corticosterone	223-237	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	157-177
7852500-1	1995	Corticosterone methyloxidase type I (CMO-I) deficiency is an autosomal recessively inherited disorder causing congenital hypoaldosteronism due to defects in aldosterone synthase (P450aldo), the enzyme that converts 11-deoxycorticosterone to corticosterone, 18-hydroxycorticosterone, and aldosterone.	Corticosterone	223-237	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	179-187
7873449-1	1995	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) reversibly converts physiological glucocorticoids (cortisol, corticosterone) to inactive 11-dehydro forms, and thus controls glucocorticoid access to receptors in a variety of tissues.	Corticosterone	112-126	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-7
7873449-1	1995	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) reversibly converts physiological glucocorticoids (cortisol, corticosterone) to inactive 11-dehydro forms, and thus controls glucocorticoid access to receptors in a variety of tissues.	Corticosterone	112-126	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	38-45
7715781-9	1995	Plasma corticosterone was lowered in vasopressin-treated rats only after previous stress.	Corticosterone	7-21	arginine vasopressin	Rattus norvegicus	37-48
7724457-4	1995	This finding supports the conclusion that the substance produced by leukocytes previously shown in our laboratory to stimulate adrenal cells to secrete corticosterone is immunoreactive ACTH.	Corticosterone	152-166	proopiomelanocortin	Homo sapiens	185-189
7829497-2	1995	One of these (CYP11B1) encodes P450c11 beta, which is the steroid 11 beta-hydroxylase found solely in the adrenal zona fasciculata/reticularis, and is responsible for the conversion of 11-deoxycorticosterone to corticosterone.	Corticosterone	193-207	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	14-21
7829497-2	1995	One of these (CYP11B1) encodes P450c11 beta, which is the steroid 11 beta-hydroxylase found solely in the adrenal zona fasciculata/reticularis, and is responsible for the conversion of 11-deoxycorticosterone to corticosterone.	Corticosterone	193-207	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	31-38
7829497-2	1995	One of these (CYP11B1) encodes P450c11 beta, which is the steroid 11 beta-hydroxylase found solely in the adrenal zona fasciculata/reticularis, and is responsible for the conversion of 11-deoxycorticosterone to corticosterone.	Corticosterone	193-207	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	58-85
7829497-12	1995	Transfection of eukaryotic cells with a vector expressing P450c11B3 shows that this form of P450c11 can convert 11-deoxycorticosterone (DOC) to corticosterone and thus has the same enzymatic activity as P450c11 beta.	Corticosterone	120-134	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	58-65
7829497-12	1995	Transfection of eukaryotic cells with a vector expressing P450c11B3 shows that this form of P450c11 can convert 11-deoxycorticosterone (DOC) to corticosterone and thus has the same enzymatic activity as P450c11 beta.	Corticosterone	120-134	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	92-99
7713161-0	1995	The corticosterone-enhancing effects of the 5-HT1A receptor antagonist, (S)-UH301, are not mediated by the 5-HT1A receptor.	Corticosterone	4-18	5-hydroxytryptamine receptor 1A	Homo sapiens	44-59
7670884-0	1995	Interleukin-1 beta induced corticosterone elevation and hypothalamic NE depletion is vagally mediated.	Corticosterone	27-41	interleukin 1 beta	Homo sapiens	0-18
7707881-0	1995	Corticosterone effects on rat calretinin mRNA in discrete brain nuclei and the testes.	Corticosterone	0-14	calbindin 2	Rattus norvegicus	30-40
7707881-2	1995	Calretinin mRNA levels were measured in discrete brain areas from vehicle and corticosterone treated rats (subcutaneous injections of 0, 0.1, 1, or 10 mg, 7 days) using a micropunch ribonuclease protection assay.	Corticosterone	78-92	calbindin 2	Rattus norvegicus	0-10
7707881-3	1995	Treatment with high dose corticosterone (10 mg) caused a 93% decrease in calretinin mRNA levels in the hypothalamic paraventricular nucleus compared to controls.	Corticosterone	25-39	calbindin 2	Rattus norvegicus	73-83
7707881-4	1995	Two other brain regions, the medial amygdaloid nucleus and the nucleus reuniens, demonstrated an approximately 40% decrease in calretinin mRNA following high dose corticosterone.	Corticosterone	163-177	calbindin 2	Rattus norvegicus	127-137
7707881-6	1995	In the testes, corticosterone treatment decreased calretinin protein in a dose dependent fashion (to 81%, 68%, and 39% of controls at doses of 10, 1, and 0.1 mg/day, respectively).	Corticosterone	15-29	calbindin 2	Rattus norvegicus	50-60
7707881-7	1995	Low dose corticosterone treatments decreased testicular but not neuronal calretinin mRNA, whereas high dose corticosterone reduced calretinin mRNA in testes and several discrete brain areas.	Corticosterone	108-122	calbindin 2	Rattus norvegicus	131-141
7707881-8	1995	This suggests that corticosterone"s effects on brain calretinin may be due to its pathological effects, e.g. energy depletion of brain cells or interference with the normal support functions of glia.	Corticosterone	19-33	calbindin 2	Rattus norvegicus	53-63
8590231-3	1995	cannula, LPS induced a rapid (15-30 min) and long-lasting (&gt; 300 min) increase in plasma ACTH and corticosterone (CORT) levels.	Corticosterone	101-115	cortistatin	Homo sapiens	117-121
7600444-4	1995	Under none of the hormonal states did ANF suppress adrenocorticotropic hormone (ACTH) stimulated corticosterone secretion.	Corticosterone	97-111	natriuretic peptide A	Rattus norvegicus	38-41
7883855-9	1995	Basal and ACTH-stimulated concentrations of cortisol, corticosterone, and 18-hydroxycorticosterone were unchanged by the concomitant infusion of endothelin-1.	Corticosterone	54-68	proopiomelanocortin	Homo sapiens	10-14
8788310-8	1995	The plasma corticosterone concentration was higher in IL-1b-treated animals than in the control group, 107.79 +/- 2.82 vs. 61.08 +/- 2.0 ng/ml, respectively, p &lt; 0.01.	Corticosterone	11-25	interleukin 1 beta	Rattus norvegicus	54-59
7557817-5	1995	The results that are reviewed herein indicate that hippocampal 5-HT1A receptors are under the tonic inhibitory control of corticosterone.	Corticosterone	122-136	5-hydroxytryptamine receptor 1A	Rattus norvegicus	63-69
8586285-3	1995	An acute intravenous injection of 1 micrograms rat CRH/100 g body weight markedly increased the plasma concentrations of ACTH, corticosterone, and aldosterone--with similar temporal kinetics in the two groups of rats.	Corticosterone	127-141	corticotropin releasing hormone	Rattus norvegicus	51-54
8586285-4	1995	However, the incremental CRH responses were significantly lower in old (approximately -70, -45-60, and -30-50%, respectively, for ACTH, corticosterone, and aldosterone) as compared with adult rats.	Corticosterone	136-150	corticotropin releasing hormone	Rattus norvegicus	25-28
9372837-8	1995	Similarly, the rate and pattern of CYP enzyme-mediated hydroxylation toward testosterone, 17 beta-estradiol, corticosterone, and lauric acid were greatly altered by nongenotoxic carcinogen treatment.	Corticosterone	109-123	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	35-38
7735296-8	1995	The 50% corticosterone pellets treatment resulted in a decrease in anterior pituitary POMC mRNA levels, a decrease in baseline and oCRH stimulated ACTH release from the anterior pituitary, and a near complete inhibition of the AM and PM response to restraint stress.	Corticosterone	8-22	proopiomelanocortin	Rattus norvegicus	86-90
7822484-9	1995	The observed differences between strains in corticosteroid-binding globulin (CBG) levels in plasma, pituitary, and immune tissue may mediate the differential access of corticosterone to neural versus immune tissues.	Corticosterone	168-182	serpin family A member 6	Rattus norvegicus	44-75
7822484-9	1995	The observed differences between strains in corticosteroid-binding globulin (CBG) levels in plasma, pituitary, and immune tissue may mediate the differential access of corticosterone to neural versus immune tissues.	Corticosterone	168-182	serpin family A member 6	Rattus norvegicus	77-80
8748620-11	1995	Furthermore, after the combined treatment with APO and HAL or APO and CLO these rat-types also differed in their amount of ACTH and corticosterone release.	Corticosterone	132-146	aminopeptidase O	Rattus norvegicus	47-50
8748620-11	1995	Furthermore, after the combined treatment with APO and HAL or APO and CLO these rat-types also differed in their amount of ACTH and corticosterone release.	Corticosterone	132-146	aminopeptidase O	Rattus norvegicus	62-65
7823188-3	1995	Corticosterone and the metabolite allotetrahydrodeoxycorticosterone exhibited a plateau of inhibition of around 15% and 25%, respectively, between 10 pM and 100 nM; both compounds continued to inhibit at concentrations &gt; 10(-7) M. Analysis of tail currents at -80 mV showed that cortisol and corticosterone had no effect on the voltage-dependent activation or deactivation of the Ca2+ channel current.	Corticosterone	0-14	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	383-386
7823188-3	1995	Corticosterone and the metabolite allotetrahydrodeoxycorticosterone exhibited a plateau of inhibition of around 15% and 25%, respectively, between 10 pM and 100 nM; both compounds continued to inhibit at concentrations &gt; 10(-7) M. Analysis of tail currents at -80 mV showed that cortisol and corticosterone had no effect on the voltage-dependent activation or deactivation of the Ca2+ channel current.	Corticosterone	53-67	LOW QUALITY PROTEIN: carbonic anhydrase 2	Cavia porcellus	383-386
7857870-8	1995	The CYP450 enzymes that hydroxylate the C19 carbon of androgens (aromatase) and the C18 carbon of corticosterone (aldosterone synthase) were selected as target enzymes because they are terminal enzymes of biosynthetic pathways which hydroxylate specific angular methyl groups.	Corticosterone	98-112	Bardet-Biedl syndrome 9	Homo sapiens	84-87
7857870-8	1995	The CYP450 enzymes that hydroxylate the C19 carbon of androgens (aromatase) and the C18 carbon of corticosterone (aldosterone synthase) were selected as target enzymes because they are terminal enzymes of biosynthetic pathways which hydroxylate specific angular methyl groups.	Corticosterone	98-112	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	114-134
7697624-3	1995	Included in this evaluation was blood withdrawal at multiple intervals for assay of plasma hormones corticosterone (CORT) and prolactin (PRL) as they were correlated with the immune phenomena associated with early (5-7d) obstruction of the catheter tip.	Corticosterone	100-114	cortistatin	Rattus norvegicus	116-120
7723602-0	1995	Corticosterone secretion in response to serotonin and ACTH by perfused adrenal of normal and athymic nude mice.	Corticosterone	0-14	pro-opiomelanocortin-alpha	Mus musculus	54-58
7723602-5	1995	Corticosterone responses to ACTH at the range of 10 to 300 pg/ml in athymic mice were comparable to those in normal mice.	Corticosterone	0-14	pro-opiomelanocortin-alpha	Mus musculus	28-32
7823760-1	1995	PACAP did not affect secretory activity of dispersed rat adrenocortical cells, but it markedly raised aldosterone (ALDO) and corticosterone (B) production by adrenal slices, containing both medullary and cortical tissues.	Corticosterone	125-139	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-5
7869837-2	1995	administration of pancreatic polypeptide (PP) dose-dependently enhanced the plasma concentration of corticosterone (PBC) in hypophysectomized/ACTH replaced rats, but not that of aldosterone.	Corticosterone	100-114	pancreatic polypeptide	Rattus norvegicus	18-40
7869837-2	1995	administration of pancreatic polypeptide (PP) dose-dependently enhanced the plasma concentration of corticosterone (PBC) in hypophysectomized/ACTH replaced rats, but not that of aldosterone.	Corticosterone	100-114	pancreatic polypeptide	Rattus norvegicus	42-44
7475953-3	1995	In AA rats injected intraperitoneally with the specific neurokinin-1 receptor antagonist RP67580, plasma ACTH and corticosterone concentrations were significantly elevated, and corticotropin-releasing hormone (CRH) mRNA in the PVN was increased compared to the AA group which received saline alone.	Corticosterone	114-128	tachykinin receptor 1	Rattus norvegicus	56-77
7596223-1	1995	Immobilization stress in rats is accompanied by a fast and transient increase in plasma catecholamines (CA) and a slow but more sustained increase in plasma corticosterone (CORT) levels.	Corticosterone	157-171	cortistatin	Rattus norvegicus	173-177
7479313-3	1995	The effects of NPY injected into the PVN and other sites include hyperphagia, reduced energy expenditure and enhanced weight gain, insulin secretion, and stimulation of corticotropin and corticosterone release.	Corticosterone	187-201	neuropeptide Y	Homo sapiens	15-18
7731494-9	1995	After 7 days of PRL infusion, LH levels had decreased by 45%, whereas plasma corticosterone was 150% higher.	Corticosterone	77-91	prolactin	Rattus norvegicus	16-19
7731494-10	1995	This action of PRL on LH and corticosterone was prevented when besides PRL also CRF antiserum was infused.	Corticosterone	29-43	prolactin	Rattus norvegicus	15-18
7731494-10	1995	This action of PRL on LH and corticosterone was prevented when besides PRL also CRF antiserum was infused.	Corticosterone	29-43	prolactin	Rattus norvegicus	71-74
7731495-0	1995	Corticosterone modulates growth hormone-releasing factor and somatostatin in fetal rat hypothalamic cultures.	Corticosterone	0-14	growth hormone releasing hormone	Rattus norvegicus	25-56
7731495-0	1995	Corticosterone modulates growth hormone-releasing factor and somatostatin in fetal rat hypothalamic cultures.	Corticosterone	0-14	somatostatin	Rattus norvegicus	61-73
7731495-3	1995	To test the hypothesis that GC can affect growth hormone-releasing releasing factor (GRF) and somatostatin (SS) at the hypothalamic level, we studied the effect of corticosterone on the immunoreactive content of GRF (IR-GRF) and SS (IR-SS) in cells and media of fetal hypothalamic cells in culture.	Corticosterone	164-178	growth hormone releasing hormone	Rattus norvegicus	212-215
7731495-4	1995	After 20 days in culture, cells were incubated with serum-free medium containing corticosterone (from 0.3 to 300 nM) for 48 h. Corticosterone had a dual effect on IR-GRF.	Corticosterone	81-95	growth hormone releasing hormone	Rattus norvegicus	163-169
7731495-4	1995	After 20 days in culture, cells were incubated with serum-free medium containing corticosterone (from 0.3 to 300 nM) for 48 h. Corticosterone had a dual effect on IR-GRF.	Corticosterone	127-141	growth hormone releasing hormone	Rattus norvegicus	163-169
7731495-7	1995	These results demonstrated that both GRF and SS are modulated by corticosterone in primary fetal rat hypothalamic cultures.	Corticosterone	65-79	growth hormone releasing hormone	Rattus norvegicus	37-40
7731495-8	1995	Whereas GRF exhibited a dual response, stimulatory and inhibitory, at low and high corticosterone doses, respectively, SS showed a parallel increase with the corticosterone concentrations.	Corticosterone	83-97	growth hormone releasing hormone	Rattus norvegicus	8-11
7708935-15	1995	These findings demonstrate that chronic treatment of some antidepressants potentiates 8-OH-DPAT-induced increase in plasma corticosterone, by actions at 5-HT-1A receptors located postsynaptically on 5-HT neurones.	Corticosterone	123-137	5-hydroxytryptamine receptor 1A	Rattus norvegicus	153-160
7651892-10	1995	Replacement with GH, PRL, T4, corticosterone, and testosterone significantly restored PACAP mRNA levels in hypophysectomized rats to those in control animals.	Corticosterone	30-44	adenylate cyclase activating polypeptide 1	Rattus norvegicus	86-91
7651896-1	1995	To investigate the role of the hormone vasopressin (VP) in mediating the response of the body to stress, corticosterone levels of VP-containing (LE) rats and VP-deficient (DI) rats were compared following administration of the dexamethasone suppression test (DST) under stressed and nonstressed conditions.	Corticosterone	105-119	arginine vasopressin	Rattus norvegicus	130-132
7651896-7	1995	Thus, in the absence of corticotropin-releasing factor, which is inhibited by DEX, VP alone appears to be sufficient to elicit significant corticosterone release.	Corticosterone	139-153	arginine vasopressin	Rattus norvegicus	83-85
8584606-15	1995	Lower levels of CRH mRNA in the hypothalamus and lower levels of ACTH and corticosterone in response to various stimuli, as well as the hyporesponsive adrenals to exogenous ACTH, are apparently the consequences of the life-long suppressive action of corticosterone via central MRs.	Corticosterone	250-264	corticotropin releasing hormone	Rattus norvegicus	16-19
7792800-1	1995	11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone, respectively, is an important pre-receptor signaling pathway for the renal mineralocorticoid receptor (MR).	Corticosterone	79-93	nuclear receptor subfamily 3 group C member 2	Homo sapiens	232-258
7792800-1	1995	11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), by converting cortisol and corticosterone to hormonally inactive cortisone and 11-dehydrocorticosterone, respectively, is an important pre-receptor signaling pathway for the renal mineralocorticoid receptor (MR).	Corticosterone	79-93	nuclear receptor subfamily 3 group C member 2	Homo sapiens	260-262
7792802-2	1995	Recently, steroid 18-hydroxylase (P450C18), or aldosterone synthase (P450aldo), was shown to be a multifunctional enzyme catalyzing these two steps of aldosterone biosynthesis, i.e., the conversion of corticosterone to 18-hydroxycorticosterone and the subsequent conversion of 18-hydroxycorticosterone to aldosterone.	Corticosterone	201-215	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	34-41
7792802-2	1995	Recently, steroid 18-hydroxylase (P450C18), or aldosterone synthase (P450aldo), was shown to be a multifunctional enzyme catalyzing these two steps of aldosterone biosynthesis, i.e., the conversion of corticosterone to 18-hydroxycorticosterone and the subsequent conversion of 18-hydroxycorticosterone to aldosterone.	Corticosterone	201-215	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	47-67
7792802-2	1995	Recently, steroid 18-hydroxylase (P450C18), or aldosterone synthase (P450aldo), was shown to be a multifunctional enzyme catalyzing these two steps of aldosterone biosynthesis, i.e., the conversion of corticosterone to 18-hydroxycorticosterone and the subsequent conversion of 18-hydroxycorticosterone to aldosterone.	Corticosterone	201-215	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	69-77
7889373-0	1994	Effect of corticosterone on the enhancement of the acoustic startle reflex by corticotropin releasing factor (CRF).	Corticosterone	10-24	corticotropin releasing hormone	Rattus norvegicus	78-108
7895055-0	1994	Hypothalamic neuropeptide Y, its gene expression and receptor activity: relation to circulating corticosterone in adrenalectomized rats.	Corticosterone	96-110	neuropeptide Y	Rattus norvegicus	13-27
7715816-2	1994	NGF induced HPAA activity as assayed by increased serum corticosterone levels in pups that were &gt; or = 15 days of age.	Corticosterone	56-70	nerve growth factor	Rattus norvegicus	0-3
7810635-1	1994	We report here that with a direct method for measurement of cardiovascular parameters in conscious rats, intracerebroventricular administration of the mineralocorticoid receptor (MR) antagonist RU-28318 (100 ng) reduces the blood pressure, heart rate, and the corticosterone response to a brief restraint stress, provided the rats were previously subjected to a daily 30-min exposure to 32 degrees C for 2 wk.	Corticosterone	260-274	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	151-177
7810635-1	1994	We report here that with a direct method for measurement of cardiovascular parameters in conscious rats, intracerebroventricular administration of the mineralocorticoid receptor (MR) antagonist RU-28318 (100 ng) reduces the blood pressure, heart rate, and the corticosterone response to a brief restraint stress, provided the rats were previously subjected to a daily 30-min exposure to 32 degrees C for 2 wk.	Corticosterone	260-274	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	179-181
7810635-5	1994	The corticosterone response to daily warming and stress is also attenuated by the intracerebroventricular infusion of MR antagonist but with shorter onset and shorter duration.	Corticosterone	4-18	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	118-120
7628063-3	1994	The effect to increase plasma corticosterone was consonant with the well-known action of IL-6 on the hypothalamus-pituitary-adrenal cortex.	Corticosterone	30-44	interleukin 6	Homo sapiens	89-93
7988417-4	1994	When rat splenocytes were preincubated with high concentrations (0.1-1 microM) of corticosterone (CORT) or with the specific glucocorticoid agonist RU 28362 (0.1 microM) for 1-6 h, washed, and then exposed to the T-cell mitogen Concanavalin-A, a time- and dose-dependent inhibition of lymphocyte mitogenesis over the next 3 days of culture was found.	Corticosterone	82-96	cortistatin	Rattus norvegicus	98-102
7988441-1	1994	11 beta-Hydroxysteroid dehydrogenase (11 beta HSD), by catalyzing the interconversion of active corticosterone (B) to inactive 11-dehydrocorticosterone (A) in the rat and cortisol (F) to cortisone in man, maintains normal in vivo specificity of the mineralocorticoid receptor (MR) in both kidney and distal colon.	Corticosterone	96-110	nuclear receptor subfamily 3 group C member 2	Homo sapiens	249-275
7867767-5	1994	Both adrenalectomy-induced p53 expression and granule cell degeneration were prevented by daily administration of corticosterone.	Corticosterone	114-128	tumor protein p53	Homo sapiens	27-30
7883143-0	1994	Corticosterone-induced insulin resistance is not associated with alterations of insulin receptor number and kinase activity in chicken kidney.	Corticosterone	0-14	insulin	Gallus gallus	23-30
7883143-3	1994	The development of an insulin resistance following corticosterone was suggested after 1 and 2 weeks of treatment by a significant increases in plasma insulin levels (1.63 +/- 0.13 vs 0.56 +/- 0.14 ng insulin/ml in controls) and in renal cytosolic phosphoenolpyruvate carboxykinase activity (17.2 +/- 0.8 vs 13.7 +/- 0.7 nm/mn/mg tissue in controls).	Corticosterone	51-65	insulin	Gallus gallus	22-29
7883143-3	1994	The development of an insulin resistance following corticosterone was suggested after 1 and 2 weeks of treatment by a significant increases in plasma insulin levels (1.63 +/- 0.13 vs 0.56 +/- 0.14 ng insulin/ml in controls) and in renal cytosolic phosphoenolpyruvate carboxykinase activity (17.2 +/- 0.8 vs 13.7 +/- 0.7 nm/mn/mg tissue in controls).	Corticosterone	51-65	insulin	Gallus gallus	150-157
7883143-3	1994	The development of an insulin resistance following corticosterone was suggested after 1 and 2 weeks of treatment by a significant increases in plasma insulin levels (1.63 +/- 0.13 vs 0.56 +/- 0.14 ng insulin/ml in controls) and in renal cytosolic phosphoenolpyruvate carboxykinase activity (17.2 +/- 0.8 vs 13.7 +/- 0.7 nm/mn/mg tissue in controls).	Corticosterone	51-65	insulin	Gallus gallus	150-157
7883143-5	1994	Therefore, in kidney and, as previously observed, in muscles, corticosterone can induce insulin resistance at postreceptor steps in the cascade of events leading to insulin action.	Corticosterone	62-76	insulin	Gallus gallus	88-95
7883143-5	1994	Therefore, in kidney and, as previously observed, in muscles, corticosterone can induce insulin resistance at postreceptor steps in the cascade of events leading to insulin action.	Corticosterone	62-76	insulin	Gallus gallus	165-172
7727801-2	1994	CRH given systemically dose-dependently increased the secretion of corticosterone.	Corticosterone	67-81	corticotropin releasing hormone	Rattus norvegicus	0-3
7727801-4	1994	In the corticosterone response to CRH administered icv, a moderate involvement of hypothalamic alpha 1-adrenergic receptors and neuronal noradrenaline seems possible.	Corticosterone	7-21	corticotropin releasing hormone	Rattus norvegicus	34-37
7727801-5	1994	The corticosterone responses to CRH given by either route to rats exposed to social crowding stress were identical with the responses of unstressed controls.	Corticosterone	4-18	corticotropin releasing hormone	Rattus norvegicus	32-35
7996433-1	1994	Treatment of rats with the serotonin 5-HT1A agonist 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT, 1 mg/kg s.c.) markedly elevated plasma levels of corticosterone (CORT), adrenocorticotropic hormone (ACTH) and prolactin (PRL); the levels of growth hormone were unaffected.	Corticosterone	153-167	5-hydroxytryptamine receptor 1A	Rattus norvegicus	37-43
7996480-2	1994	The 5-HT2A/5-HT2C agonist (+/-(-)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HC1 (DOI) increased plasma ACTH and corticosterone in a dose-dependent manner.	Corticosterone	115-129	5-hydroxytryptamine receptor 2A	Rattus norvegicus	4-10
7996480-2	1994	The 5-HT2A/5-HT2C agonist (+/-(-)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HC1 (DOI) increased plasma ACTH and corticosterone in a dose-dependent manner.	Corticosterone	115-129	5-hydroxytryptamine receptor 2C	Rattus norvegicus	11-17
7996480-2	1994	The 5-HT2A/5-HT2C agonist (+/-(-)1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane HC1 (DOI) increased plasma ACTH and corticosterone in a dose-dependent manner.	Corticosterone	115-129	Hypercalciuria QTL 1	Rattus norvegicus	79-82
7877726-9	1994	These data suggested that stimulation of CA1 pyramidal cells may lead to increased corticosterone release and that a decrease in hippocampal noradrenaline concentration was unable to alter this corticosterone response.	Corticosterone	83-97	carbonic anhydrase 1	Rattus norvegicus	41-44
7825887-2	1994	In the case of LEW/N rats, several lines of evidence indicate that CRH is aberrantly regulated, and as a consequence, the circulating corticosterone concentrations are blunted.	Corticosterone	134-148	corticotropin releasing hormone	Rattus norvegicus	67-70
7825906-0	1994	Social defeat impairs plasma corticosterone response to the 5-HT1A agonist 8-OH-DPAT in the rat.	Corticosterone	29-43	5-hydroxytryptamine receptor 1A	Rattus norvegicus	60-66
7825915-0	1994	Calbindin-D28K and parvalbumin immunoreactivity in the rat hippocampus following adrenalectomy and corticosterone treatment.	Corticosterone	99-113	parvalbumin	Rattus norvegicus	19-30
7979370-6	1994	The relationship of the plasma corticosterone level to the AldB mRNA level was not obvious.	Corticosterone	31-45	aldolase, fructose-bisphosphate B	Rattus norvegicus	59-63
7895055-1	1994	Previous evidence has suggested a possible relationship between the adrenal steroid, corticosterone (CORT) and neuropeptide Y (NPY) in the brain.	Corticosterone	85-99	neuropeptide Y	Rattus norvegicus	111-125
7895055-1	1994	Previous evidence has suggested a possible relationship between the adrenal steroid, corticosterone (CORT) and neuropeptide Y (NPY) in the brain.	Corticosterone	85-99	neuropeptide Y	Rattus norvegicus	127-130
7895055-1	1994	Previous evidence has suggested a possible relationship between the adrenal steroid, corticosterone (CORT) and neuropeptide Y (NPY) in the brain.	Corticosterone	101-105	neuropeptide Y	Rattus norvegicus	111-125
7895055-1	1994	Previous evidence has suggested a possible relationship between the adrenal steroid, corticosterone (CORT) and neuropeptide Y (NPY) in the brain.	Corticosterone	101-105	neuropeptide Y	Rattus norvegicus	127-130
7956913-0	1994	Transcriptional control of glial fibrillary acidic protein and glutamine synthetase in vivo shows opposite responses to corticosterone in the hippocampus.	Corticosterone	120-134	glial fibrillary acidic protein	Rattus norvegicus	27-58
7956913-0	1994	Transcriptional control of glial fibrillary acidic protein and glutamine synthetase in vivo shows opposite responses to corticosterone in the hippocampus.	Corticosterone	120-134	glutamate-ammonia ligase	Rattus norvegicus	63-83
7956913-2	1994	Transcriptional responses of GFAP to corticosterone were slower than those observed for GS, but were more sensitive to changes in plasma corticosterone.	Corticosterone	37-51	glial fibrillary acidic protein	Rattus norvegicus	29-33
7956913-2	1994	Transcriptional responses of GFAP to corticosterone were slower than those observed for GS, but were more sensitive to changes in plasma corticosterone.	Corticosterone	137-151	glial fibrillary acidic protein	Rattus norvegicus	29-33
7956913-3	1994	The transcription of GFAP did not change 2 h after the injection of 10 mg corticosterone, but was reduced by 50% at 6 and 24 h. In contrast, corticosterone increased GS transcription at 2 and 6 h. Seven days after adrenalectomy, GFAP, but not GS, transcription was increased.	Corticosterone	74-88	glial fibrillary acidic protein	Rattus norvegicus	21-25
7956913-3	1994	The transcription of GFAP did not change 2 h after the injection of 10 mg corticosterone, but was reduced by 50% at 6 and 24 h. In contrast, corticosterone increased GS transcription at 2 and 6 h. Seven days after adrenalectomy, GFAP, but not GS, transcription was increased.	Corticosterone	141-155	glial fibrillary acidic protein	Rattus norvegicus	229-233
7956913-4	1994	Corticosterone replacement (200 micrograms/ml in the drinking water) suppressed GFAP, but did not increase GS transcription in adrenalectomized rats.	Corticosterone	0-14	glial fibrillary acidic protein	Rattus norvegicus	80-84
7956913-5	1994	Therefore, GFAP transcription is more sensitive to low physiological levels of corticosterone than transcription of GS.	Corticosterone	79-93	glial fibrillary acidic protein	Rattus norvegicus	11-15
7956913-6	1994	The slower response of GFAP than GS to corticosterone suggests that glucocorticoids may have indirect effects on GFAP expression that require additional transcriptional regulators besides the glucocorticoid receptor.	Corticosterone	39-53	glial fibrillary acidic protein	Rattus norvegicus	23-27
7952166-2	1994	Thus, corticosterone secretion in rats was investigated following lipopolysaccharide (LPS), acute cold-swimming or ether stress or synthetic corticotrophin-releasing factor (CRF) administration throughout the oestrous cycle.	Corticosterone	6-20	corticotropin releasing hormone	Rattus norvegicus	141-172
7956913-6	1994	The slower response of GFAP than GS to corticosterone suggests that glucocorticoids may have indirect effects on GFAP expression that require additional transcriptional regulators besides the glucocorticoid receptor.	Corticosterone	39-53	glial fibrillary acidic protein	Rattus norvegicus	113-117
7956913-6	1994	The slower response of GFAP than GS to corticosterone suggests that glucocorticoids may have indirect effects on GFAP expression that require additional transcriptional regulators besides the glucocorticoid receptor.	Corticosterone	39-53	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	192-215
7956928-16	1994	Exogenous corticosterone inhibited ACTH-induced P450scc mRNA accumulation by 50%, whereas etomidate doubled it.	Corticosterone	10-24	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	48-55
7956928-18	1994	In addition, a high corticosterone concentration may inhibit steroidogenesis by reducing P450scc expression.	Corticosterone	20-34	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	89-96
7824596-6	1994	Stressed rats exhibited elevated basal plasma corticosterone (CORT) levels 1 day poststressor which recovered by 9 days poststressor.	Corticosterone	46-60	cortistatin	Rattus norvegicus	62-66
7898612-2	1994	In this study, corticosterone was found to prevent temperature-dependent dissociation of endogenous calmodulin (CaM) from highly purified SPM from rat cerebral cortex.	Corticosterone	15-29	calmodulin 1	Rattus norvegicus	100-110
7898612-2	1994	In this study, corticosterone was found to prevent temperature-dependent dissociation of endogenous calmodulin (CaM) from highly purified SPM from rat cerebral cortex.	Corticosterone	15-29	calmodulin 1	Rattus norvegicus	112-115
7898612-4	1994	The stabilization of membrane binding of endogenous CaM by corticosterone is concentration-dependent, with the maximal effect occurring at steroid concentration of 1 microM.	Corticosterone	59-73	calmodulin 1	Rattus norvegicus	52-55
7898612-6	1994	The effect in stabilizing membrane binding of CaM is specific to corticosterone and other glucocorticoids (cortisol, dexamethasone and triamcinolone); gonadal steroids (17 (17 beta-estradiol, progesterone and testosterone) are ineffective.	Corticosterone	65-79	calmodulin 1	Rattus norvegicus	46-49
7854057-5	1994	After 7 days of adrenalectomy (ADX), there was an increase in the level of GAP-43 mRNA expression in the CA1 and CA3 pyramidal cell layers of the hippocampus, that was prevented by corticosterone replacement to the ADX animals.	Corticosterone	181-195	growth associated protein 43	Rattus norvegicus	75-81
7834390-6	1994	The direct corticosterone secretagogue effect of 10(-8) M NPK is annulled by 10(-6) M alpha-helical-CRH or corticotropin-inhibiting peptide, competitive inhibitors of CRH and ACTH, respectively.	Corticosterone	11-25	corticotropin releasing hormone	Rattus norvegicus	100-103
7834390-6	1994	The direct corticosterone secretagogue effect of 10(-8) M NPK is annulled by 10(-6) M alpha-helical-CRH or corticotropin-inhibiting peptide, competitive inhibitors of CRH and ACTH, respectively.	Corticosterone	11-25	corticotropin releasing hormone	Rattus norvegicus	167-170
7854057-5	1994	After 7 days of adrenalectomy (ADX), there was an increase in the level of GAP-43 mRNA expression in the CA1 and CA3 pyramidal cell layers of the hippocampus, that was prevented by corticosterone replacement to the ADX animals.	Corticosterone	181-195	carbonic anhydrase 1	Rattus norvegicus	105-108
7854057-5	1994	After 7 days of adrenalectomy (ADX), there was an increase in the level of GAP-43 mRNA expression in the CA1 and CA3 pyramidal cell layers of the hippocampus, that was prevented by corticosterone replacement to the ADX animals.	Corticosterone	181-195	carbonic anhydrase 3	Rattus norvegicus	113-116
7848528-1	1994	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the metabolism of corticosterone to inert 11-dehydrocorticosterone, thus preventing glucocorticoid access to otherwise non-selective renal mineralocorticoid receptors (MRs), producing aldosterone selectivity in vivo.	Corticosterone	79-93	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	0-7
7848528-1	1994	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) catalyses the metabolism of corticosterone to inert 11-dehydrocorticosterone, thus preventing glucocorticoid access to otherwise non-selective renal mineralocorticoid receptors (MRs), producing aldosterone selectivity in vivo.	Corticosterone	79-93	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	38-45
7931278-6	1994	Corticosterone and to a lesser extent aldosterone also significantly potentiated PIA-dependent cAMP accumulation.	Corticosterone	0-14	RPTOR independent companion of MTOR complex 2	Homo sapiens	81-84
8088915-2	1994	Evidence to support a hypertensinogenic role of family 3A cytochrome P-450 (CYP3A) activity is that troleandomycin, a selective inhibitor of CYP3A, decreases both blood pressure and in vivo corticosterone 6 beta-hydroxylation in spontaneously hypertensive rats (SHR).	Corticosterone	190-204	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	76-81
8088915-2	1994	Evidence to support a hypertensinogenic role of family 3A cytochrome P-450 (CYP3A) activity is that troleandomycin, a selective inhibitor of CYP3A, decreases both blood pressure and in vivo corticosterone 6 beta-hydroxylation in spontaneously hypertensive rats (SHR).	Corticosterone	190-204	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	141-146
7931560-7	1994	Plasma concentrations of adrenocorticotropic hormone, corticosterone, and IL-6 were increased by CRH infusion into the locus coeruleus.	Corticosterone	54-68	corticotropin releasing hormone	Rattus norvegicus	97-100
7931294-7	1994	Other steroids such as testosterone (Tes), estradiol (Est), and corticosterone (Cor) were less effective, whereas pregnenolone sulfate (PS) and cholesterol (Cho) were ineffective.	Corticosterone	64-78	distribution of corticosterone in adrenal cortex cells	Mus musculus	80-83
7965707-6	1994	DOM-induced corticosterone secretion appears to be mediated by stimulation of 5-HT2A and/or 5-HT2C receptors.	Corticosterone	12-26	5-hydroxytryptamine receptor 2A	Rattus norvegicus	78-84
7965707-6	1994	DOM-induced corticosterone secretion appears to be mediated by stimulation of 5-HT2A and/or 5-HT2C receptors.	Corticosterone	12-26	5-hydroxytryptamine receptor 2C	Rattus norvegicus	92-98
7878688-1	1994	Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions.	Corticosterone	128-142	serpin family A member 6	Homo sapiens	0-31
7878688-1	1994	Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions.	Corticosterone	128-142	serpin family A member 6	Homo sapiens	33-36
7878688-1	1994	Corticosteroid-binding globulin (CBG or transcortin) is a specific plasma glycoprotein, which binds steroid hormones (cortisol, corticosterone, and progesterone), and plays a role in transporting these steroids, altering their concentrations in blood, and influencing their biological actions.	Corticosterone	128-142	serpin family A member 6	Homo sapiens	40-51
7820612-0	1994	Effects of corticosterone on CRH mRNA and content in the bed nucleus of the stria terminalis; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus.	Corticosterone	11-25	corticotropin releasing hormone	Rattus norvegicus	29-32
7820612-1	1994	We previously reported that corticosterone (CORT) increased corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA), while reducing it in the paraventricular nucleus (PVN) of the hypothalamus by using in situ hybridization histochemistry.	Corticosterone	28-42	corticotropin releasing hormone	Rattus norvegicus	60-91
7820612-1	1994	We previously reported that corticosterone (CORT) increased corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA), while reducing it in the paraventricular nucleus (PVN) of the hypothalamus by using in situ hybridization histochemistry.	Corticosterone	28-42	corticotropin releasing hormone	Rattus norvegicus	93-96
7820612-1	1994	We previously reported that corticosterone (CORT) increased corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA), while reducing it in the paraventricular nucleus (PVN) of the hypothalamus by using in situ hybridization histochemistry.	Corticosterone	28-42	carcinoembryonic antigen gene family 4	Rattus norvegicus	143-146
7820612-1	1994	We previously reported that corticosterone (CORT) increased corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA), while reducing it in the paraventricular nucleus (PVN) of the hypothalamus by using in situ hybridization histochemistry.	Corticosterone	44-48	corticotropin releasing hormone	Rattus norvegicus	60-91
7820612-1	1994	We previously reported that corticosterone (CORT) increased corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA), while reducing it in the paraventricular nucleus (PVN) of the hypothalamus by using in situ hybridization histochemistry.	Corticosterone	44-48	corticotropin releasing hormone	Rattus norvegicus	93-96
7820612-1	1994	We previously reported that corticosterone (CORT) increased corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA), while reducing it in the paraventricular nucleus (PVN) of the hypothalamus by using in situ hybridization histochemistry.	Corticosterone	44-48	carcinoembryonic antigen gene family 4	Rattus norvegicus	143-146
7530059-3	1994	Inhibition of both the constitutive and the inducible forms of nitric oxide synthase prevented IL-1 beta-induced fever, hyperglycaemia, hypoinsulinemia, and hyperglucagonemia, and partially prevented lymphopenia and neutrophilia, but had no effect on IL-1 beta-induced anorexia and changes in plasma corticosterone.	Corticosterone	300-314	interleukin 1 beta	Rattus norvegicus	95-104
7765856-1	1994	The effect of dexamethasone (DEX) and corticosterone (COR) on the activity of monoamine oxidase (MAO), copper-zinc superoxide dismutase (CuZn SOD) and manganese superoxide dismutase (Mn SOD) in the rat interscapular brown adipose tissue (IBAT) were studied.	Corticosterone	38-52	monoamine oxidase A	Rattus norvegicus	78-95
7765856-1	1994	The effect of dexamethasone (DEX) and corticosterone (COR) on the activity of monoamine oxidase (MAO), copper-zinc superoxide dismutase (CuZn SOD) and manganese superoxide dismutase (Mn SOD) in the rat interscapular brown adipose tissue (IBAT) were studied.	Corticosterone	54-57	monoamine oxidase A	Rattus norvegicus	78-95
7804847-6	1994	Daily intake of 3% saline was monitored in all rats and serum corticosterone (Cort) was measured.	Corticosterone	62-76	cortistatin	Rattus norvegicus	78-82
7522168-8	1994	In IL-6(0/0) mice, less corticosterone was induced by TNF than in the control mice, while the response to adrenocorticotropic hormone was the same.	Corticosterone	24-38	interleukin 6	Mus musculus	3-7
7522168-8	1994	In IL-6(0/0) mice, less corticosterone was induced by TNF than in the control mice, while the response to adrenocorticotropic hormone was the same.	Corticosterone	24-38	tumor necrosis factor	Mus musculus	54-57
8077359-5	1994	The ratios of both corticosterone/11-deoxycorticosterone and cortisol/11-deoxycortisol were abnormally low, and decreased further 60 min after administration of ACTH-(1-24) (250 micrograms) as an i.v.	Corticosterone	19-33	proopiomelanocortin	Homo sapiens	161-165
7528869-2	1994	In light of evidence showing GAL to alter the release of the adrenal steroid, corticosterone (CORT), a possible effect of this steroid on GAL gene expression and peptide production in discrete hypothalamic and brainstem sites was investigated.	Corticosterone	78-92	galanin and GMAP prepropeptide	Rattus norvegicus	29-32
7528869-2	1994	In light of evidence showing GAL to alter the release of the adrenal steroid, corticosterone (CORT), a possible effect of this steroid on GAL gene expression and peptide production in discrete hypothalamic and brainstem sites was investigated.	Corticosterone	78-92	cortistatin	Rattus norvegicus	94-98
7528869-2	1994	In light of evidence showing GAL to alter the release of the adrenal steroid, corticosterone (CORT), a possible effect of this steroid on GAL gene expression and peptide production in discrete hypothalamic and brainstem sites was investigated.	Corticosterone	78-92	galanin and GMAP prepropeptide	Rattus norvegicus	138-141
7519667-4	1994	Corticosterone did not uniformly affect HO-2 protein expression in all regions, but appeared to cause a universal reduction in NO synthase, e.g., HO-2 was decreased in hippocampus (CA1 and dentate gyrus), but not in cerebellum.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	181-184
8071432-4	1994	The effect of restraint and of corticosterone on macrophage function was abrogated by either treating mice with the glucocorticoid receptor antagonist RU486 or the addition of the drug to cultures of macrophages.	Corticosterone	31-45	nuclear receptor subfamily 3, group C, member 1	Mus musculus	116-139
7519667-3	1994	Corticosterone treatment (40 mg/kg, 20 days) had opposing effects on HO-2 and NO synthase transcript levels: increasing the 1.3- and 1.9-kb HO-2 mRNAs and decreasing that of the brain-specific 10.5-kb NO synthase.	Corticosterone	0-14	heme oxygenase 2	Rattus norvegicus	69-73
7519667-3	1994	Corticosterone treatment (40 mg/kg, 20 days) had opposing effects on HO-2 and NO synthase transcript levels: increasing the 1.3- and 1.9-kb HO-2 mRNAs and decreasing that of the brain-specific 10.5-kb NO synthase.	Corticosterone	0-14	heme oxygenase 2	Rattus norvegicus	140-144
7519667-4	1994	Corticosterone did not uniformly affect HO-2 protein expression in all regions, but appeared to cause a universal reduction in NO synthase, e.g., HO-2 was decreased in hippocampus (CA1 and dentate gyrus), but not in cerebellum.	Corticosterone	0-14	heme oxygenase 2	Rattus norvegicus	146-150
7841454-5	1994	Mepyramine, a histamine H1-receptor antagonist, moderately diminished the carbachol-induced corticosterone response and abolished the rise in hypothalamic histamine levels.	Corticosterone	92-106	histamine receptor H 1	Rattus norvegicus	14-35
7969784-0	1994	Long- and short-term administration of corticosterone alters CA1 hippocampal neuronal properties.	Corticosterone	39-53	carbonic anhydrase 1	Rattus norvegicus	61-64
7894535-6	1994	Since TRH in the adrenal medulla is thought to exert a paracrine, inhibitory influence on the adrenal cortex, depletion of the peptide content may contribute to a persistent elevation of the plasma corticosterone level following repeated treatment with amphetamine.	Corticosterone	198-212	thyrotropin releasing hormone	Rattus norvegicus	6-9
8071432-5	1994	Activation of the HPA axis as well as the addition of corticosterone to cultures of macrophages resulted in a suppression of the production of tumor necrosis factor (TNF)-alpha and of reactive nitrogen intermediates by macrophages from both strains of mice.	Corticosterone	54-68	tumor necrosis factor	Mus musculus	143-176
7982101-3	1994	Using D-[2,3-3H]aspartic acid ([3H]D-Asp) as a tracer, we found that corticosterone (CORT, the physiological GC in rats) increased the accumulation of extracellular [3H]D-Asp by 25% in hippocampal cultures during cyanide-induced ischemia.	Corticosterone	69-83	cortistatin	Rattus norvegicus	85-89
8070532-1	1994	Injection of corticosterone into CBA/Lac, C57BL/6J and BALB/c mice, or hydrocortisone into aggressive and domesticated rats, on days 16 and 18 of pregnancy decreased the weight of sexual glands in adult male offspring of the C57BL/6J and domesticated mothers but increased these values in male offspring of the CBA/Lac and aggressive mothers.	Corticosterone	13-27	lactase	Mus musculus	37-40
8070532-1	1994	Injection of corticosterone into CBA/Lac, C57BL/6J and BALB/c mice, or hydrocortisone into aggressive and domesticated rats, on days 16 and 18 of pregnancy decreased the weight of sexual glands in adult male offspring of the C57BL/6J and domesticated mothers but increased these values in male offspring of the CBA/Lac and aggressive mothers.	Corticosterone	13-27	lactase	Mus musculus	315-318
7913957-8	1994	Corticotropin-releasing hormone mRNA levels were doubled in the paraventricular nucleus at 1 and 3 hr, concomitant with elevations in plasma adrenocorticotrophic hormone (ACTH) and corticosterone.	Corticosterone	181-195	corticotropin releasing hormone	Rattus norvegicus	0-31
7518383-7	1994	Moreover, intrahippocampal administration of hIL-1 beta increased hypothalamic-pituitary-adrenocortical axis activity, as evidenced by marked increases in both plasma ACTH and plasma and dialysate corticosterone levels.	Corticosterone	197-211	interleukin 1 beta	Homo sapiens	45-55
7518383-8	1994	In addition, a rise in body temperature by approximately 2 C was observed at time points at which the effects of hIL-1 beta on 5-HT and corticosterone levels were (near-)maximal.	Corticosterone	136-150	interleukin 1 beta	Homo sapiens	113-123
7914405-7	1994	Different degrees of stimulation of the Pgp ATPase activity were also obtained in the presence of steroid hormones such as progesterone, beta-estradiol, hydrocortisone, and corticosterone.	Corticosterone	173-187	ATP binding cassette subfamily B member 1	Homo sapiens	40-43
7969768-1	1994	The purpose of this study was to determine whether estrogen and progesterone influence fast glucocorticoid negative feedback regulation of the ACTH and corticosterone (CORT) responses to stress.	Corticosterone	152-166	cortistatin	Rattus norvegicus	168-172
7969769-10	1994	An autoradiographic procedure revealed that the same treatment with IL1 reduced the retention of the tritiated endogenous MR ligand corticosterone by 40-60% in all pyramidal cell layers and in the dentate gyrus of the hippocampus, when a tracer dose of the steroid was administered that gives rise to a concentration around the Kd of the MR.	Corticosterone	132-146	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	122-124
7969769-10	1994	An autoradiographic procedure revealed that the same treatment with IL1 reduced the retention of the tritiated endogenous MR ligand corticosterone by 40-60% in all pyramidal cell layers and in the dentate gyrus of the hippocampus, when a tracer dose of the steroid was administered that gives rise to a concentration around the Kd of the MR.	Corticosterone	132-146	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	338-340
8048512-7	1994	In these rats, the elevated plasma levels of insulin, glucagon, and corticosterone produced by intracerebroventricular injection of IL-1 alpha were still present.	Corticosterone	68-82	interleukin 1 alpha	Rattus norvegicus	132-142
7914070-7	1994	Finally, suppression of endogenous corticosterone with dexamethasone delayed the stress-induced increase in activity of PNMT but not TH.	Corticosterone	35-49	phenylethanolamine-N-methyltransferase	Rattus norvegicus	120-124
8033416-8	1994	Administration of IL-1 alpha induced identical corticosterone responses in both CV and GF F344 rats.	Corticosterone	47-61	interleukin 1 alpha	Rattus norvegicus	18-28
8013380-6	1994	Graded doses of frog CGRP (from 3 x 10(-9) to 3 x 10(-6) M) increased corticosterone and aldosterone secretion in a dose-dependent manner (ED50, 4.1 x 10(-8) M).	Corticosterone	70-84	calcitonin-related polypeptide alpha	Rattus norvegicus	21-25
8013385-1	1994	Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells.	Corticosterone	101-115	interleukin 1 alpha	Rattus norvegicus	57-76
8013385-1	1994	Studies from this and other laboratories have shown that interleukin-1 alpha (IL-1 alpha) stimulates corticosterone and prostaglandin (PG) release from primary cultures of rat adrenal cells.	Corticosterone	101-115	interleukin 1 alpha	Rattus norvegicus	78-88
8013385-2	1994	A previous report from our laboratory (1) indicated involvement of the alpha-adrenergic system in IL-1 alpha-stimulated corticosterone secretion from primary cultures of rat adrenal cells.	Corticosterone	120-134	interleukin 1 alpha	Rattus norvegicus	98-108
8013385-9	1994	IL-1 alpha significantly increased (P &lt; 0.05) epinephrine, PGE2, and corticosterone levels above those in medium-treated controls from primary adrenal cells.	Corticosterone	72-86	interleukin 1 alpha	Rattus norvegicus	0-10
8013385-10	1994	In the presence of the alpha-adrenergic antagonist phentolamine (10 microM), IL-1 alpha-stimulated (P &lt; 0.05) corticosterone release was inhibited, whereas IL-1 alpha-induced PGE2 release was not affected.	Corticosterone	113-127	interleukin 1 alpha	Rattus norvegicus	77-87
7958733-6	1994	administration of the delta-selective agonist DPDPE ([D-Pen2,D-Pen2]enkephalin) produced stimulation of HPA activity, as shown by an increase in corticosterone release.	Corticosterone	145-159	proenkephalin	Rattus norvegicus	68-78
8049134-1	1994	In a previous report, we have shown that endothelin-1 (ET-1) is a potent stimulator of corticosterone and aldosterone secretion by frog adrenocortical cells.	Corticosterone	87-101	endothelin 1	Canis lupus familiaris	41-53
8049134-1	1994	In a previous report, we have shown that endothelin-1 (ET-1) is a potent stimulator of corticosterone and aldosterone secretion by frog adrenocortical cells.	Corticosterone	87-101	endothelin 1	Canis lupus familiaris	55-59
7958398-0	1994	Regulation of HSP90 and corticosteroid receptor mRNA by corticosterone levels in vivo.	Corticosterone	56-70	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	14-19
7958398-8	1994	Moderate elevation of circulating corticosterone levels normalized ADX/GX-increased hsp90 mRNA concentrations in the hippocampus and the hypothalamic paraventricular nucleus (PVN); this was associated with similar changes in GR and MR mRNA levels in the hippocampus, while GR mRNA concentrations in the PVN were not altered.	Corticosterone	34-48	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	84-89
7969816-9	1994	These findings suggest that the central CRH system may participate in the regulation of corticosterone and neurohypophysial hormone secretion evoked by acute osmotic challenge.	Corticosterone	88-102	corticotropin releasing hormone	Rattus norvegicus	40-43
7969816-0	1994	The role of central corticoliberin in the hyperosmosis-induced secretion of neurohypophysial hormones and corticosterone in the rat.	Corticosterone	106-120	corticotropin releasing hormone	Rattus norvegicus	20-34
7969816-3	1994	administered CRH-antiserum (AS) on the hyperosmosis-induced secretion of arginine-8-vasopressin (AVP), oxytocin (OXT) and corticosterone in Wistar male rats.	Corticosterone	122-136	corticotropin releasing hormone	Rattus norvegicus	13-16
7969816-8	1994	CRH-AS pretreatment prevented the corticosterone-releasing action of HS, and significantly moderated the HS-induced AVP and OXT increase.	Corticosterone	34-48	corticotropin releasing hormone	Rattus norvegicus	0-3
8090279-5	1994	GPDH mRNA increased up to 10-fold in a dose-dependent manner in response to acute corticosterone (CORT) treatment (8 h-3 days) of adrenalectomized (ADX) rats.	Corticosterone	82-96	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	0-4
8090279-5	1994	GPDH mRNA increased up to 10-fold in a dose-dependent manner in response to acute corticosterone (CORT) treatment (8 h-3 days) of adrenalectomized (ADX) rats.	Corticosterone	98-102	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	0-4
8090280-1	1994	Corticosterone (CORT) can alter several electrophysiological properties in the hippocampus.	Corticosterone	0-14	cortistatin	Mus musculus	16-20
7831193-4	1994	In vivo interleukin-1 beta (IL-1 beta), given orally or peripherally, produced increases (P &lt; 0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone.	Corticosterone	113-127	interleukin 1 beta	Homo sapiens	8-26
7831193-4	1994	In vivo interleukin-1 beta (IL-1 beta), given orally or peripherally, produced increases (P &lt; 0.01) the serum corticosterone concentration which were reversed by pretreatment with dexamethasone.	Corticosterone	113-127	interleukin 1 beta	Homo sapiens	28-37
7953638-1	1994	Pyramidal CA1 neurons in the rat hippocampus contain mineralocorticoid (MRs) and glucocorticoid receptors (GRs) for corticosterone, which, in activated form, act as transcription factors of the genome.	Corticosterone	116-130	carbonic anhydrase 1	Rattus norvegicus	10-13
8030854-4	1994	Corticosterone prolonged treatment resulted in morphological changes mainly in the CA1, CA4, and dentate gyrus areas of the hippocampus.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	83-86
8030854-4	1994	Corticosterone prolonged treatment resulted in morphological changes mainly in the CA1, CA4, and dentate gyrus areas of the hippocampus.	Corticosterone	0-14	carbonic anhydrase 4	Rattus norvegicus	88-91
8018704-9	1994	The binding of corticosterone to P-450(11)beta was concluded quite weak in proteoliposomes in the presence of P-450scc and in the Tween-20 solubilized state.	Corticosterone	15-29	cholesterol side-chain cleavage enzyme, mitochondrial	Bos taurus	110-118
7976811-2	1994	The corticosterone response to intraventricular administration of pyridylethylamine (PEA), a histamine H1-receptor agonist, was significantly higher in isolated than in control rats.	Corticosterone	4-18	histamine receptor H 1	Rattus norvegicus	93-114
7976811-3	1994	The corticosterone response to dimaprit, a histamine H2-receptor agonist, tended to be slightly weaker in the stressed rather than in control rats.	Corticosterone	4-18	histamine receptor H 2	Rattus norvegicus	43-64
7976812-1	1994	Social stress of crowding for 3, 7, 14 and 21 days drastically reduces the serum corticosterone response to intracerebroventricular administration of dimaprit, a histamine H2-receptor agonist, moderately diminishes the response to pyridylethylamine, an H1-receptor agonist, and does not change significantly the corticosterone response to histamine.	Corticosterone	81-95	histamine receptor H 2	Rattus norvegicus	162-183
8023931-0	1994	Effect of IL-1 receptor antagonist and antiserum to TNF-alpha on LPS-induced plasma ACTH and corticosterone rise in rats.	Corticosterone	93-107	tumor necrosis factor	Rattus norvegicus	52-61
8023931-4	1994	Plasma ACTH and corticosterone levels in these rats were completely inhibited by the intravenous administration of anti-murine TNF-alpha-rabbit antiserum (anti-TNFAS) after the administration of LPS but not by the intravenous administration of IL-1 receptor antagonist (IL-1RA).	Corticosterone	16-30	tumor necrosis factor	Rattus norvegicus	127-136
8023931-6	1994	These findings indicate that 1) when the plasma corticosterone increase induced by intravenous LPS remains below its maximum, the effect is exclusively mediated by TNF-alpha, and 2) when a larger amount of LPS is administered, both IL-1 beta and TNF-alpha participate at least in part in the hypothalamic-pituitary-adrenal axis activation.	Corticosterone	48-62	tumor necrosis factor	Rattus norvegicus	164-173
8023931-6	1994	These findings indicate that 1) when the plasma corticosterone increase induced by intravenous LPS remains below its maximum, the effect is exclusively mediated by TNF-alpha, and 2) when a larger amount of LPS is administered, both IL-1 beta and TNF-alpha participate at least in part in the hypothalamic-pituitary-adrenal axis activation.	Corticosterone	48-62	tumor necrosis factor	Rattus norvegicus	246-255
7949017-0	1994	Effect of POMC-derived peptides on corticosterone secretion during the stress hypo-responsive period in rat.	Corticosterone	35-49	proopiomelanocortin	Rattus norvegicus	10-14
7523979-4	1994	Both vasoactive intestinal polypeptide and Met-enkephalin caused a dose-dependent increase in corticosterone secretion, with a maximum response of 450% and 370% increment in corticosterone respectively.	Corticosterone	94-108	vasoactive intestinal peptide	Rattus norvegicus	5-38
7523979-4	1994	Both vasoactive intestinal polypeptide and Met-enkephalin caused a dose-dependent increase in corticosterone secretion, with a maximum response of 450% and 370% increment in corticosterone respectively.	Corticosterone	174-188	vasoactive intestinal peptide	Rattus norvegicus	5-38
7523979-5	1994	Of the other peptides tested, Leu-enkephalin, substance P and neurotensin all stimulated corticosterone secretion, with a maximum response of around 160% increase in each case.	Corticosterone	89-103	neurotensin	Rattus norvegicus	62-73
8203629-7	1994	This implies that type II receptor stimulation by high physiological concentrations of serum corticosterone may also increase NPY gene expression in the basomedial hypothalamus.	Corticosterone	93-107	neuropeptide Y	Rattus norvegicus	126-129
8156919-11	1994	When tested with [3H]corticosterone and [3H]progesterone as exogenous substrates, 1-10 microM cotinine caused a significant dose-dependent inhibition of ACTH- and ANG-II-stimulated aldosterone synthesis.	Corticosterone	21-35	angiotensinogen	Rattus norvegicus	163-169
8077603-5	1994	The stress-induced increase in serum corticosterone levels in mice injected with LPS alone was not further increased by treatment with CRF.	Corticosterone	37-51	toll-like receptor 4	Mus musculus	81-84
8046298-9	1994	Reduction (50-75%) of cholesterol side-chain cleavage enzyme (P450scc) mRNA expression was also noted with H-7 in ACTH-treated cultures after 6 and 24 h. In contrast, TPA doubled the corticosterone secretion induced by 8-Br cAMP, but did not further increase the ACTH-induced secretion after 24 h. TPA alone, however, was not able to induce steroid secretion or P450scc mRNA expression.	Corticosterone	183-197	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	62-69
8177041-11	1994	Treatment with oCRH or vasopressin for 8 days normalized plasma and pituitary corticotropin, as well as plasma corticosterone.	Corticosterone	111-125	arginine vasopressin	Rattus norvegicus	23-34
7518332-8	1994	In addition to the neurochemical changes, plasma corticosterone concentrations were profoundly enhanced in IL-1-treated animals, but not significantly altered by IL-2 or IL-6 treatment.	Corticosterone	49-63	interleukin 1 complex	Mus musculus	107-111
7518332-9	1994	The IL-1-induced corticosterone elevations did not significantly correlate with alterations of hypothalamic NE activity.	Corticosterone	17-31	interleukin 1 complex	Mus musculus	4-8
8528886-4	1994	In this study, we report the effects of EBT- and case-associated L-Trp on CRH mRNA expression in the hypothalamic PVN and secretion of adrenocorticotropic hormone (ACTH) and corticosterone (CORT) into the plasma over a time course of 1-6 weeks in the same rats in which we have found fascial thickening and immune cell activation induced by these compounds.	Corticosterone	190-194	corticotropin releasing hormone	Rattus norvegicus	74-77
8013385-13	1994	These observations indicate that IL-1 alpha stimulates corticosterone release through an alpha-adrenergic mechanism that is independent of PGE2 release from primary rat adrenal cells.	Corticosterone	55-69	interleukin 1 alpha	Rattus norvegicus	33-43
8137762-10	1994	PTHrP suppression by stress is caused by the increase in corticosterone, as pretreatment of metyrapone, an inhibitor of 11 beta-hydroxylation, enhanced PTHrP gene expression in association with serum corticosterone suppression.	Corticosterone	57-71	parathyroid hormone-like hormone	Rattus norvegicus	0-5
8137762-10	1994	PTHrP suppression by stress is caused by the increase in corticosterone, as pretreatment of metyrapone, an inhibitor of 11 beta-hydroxylation, enhanced PTHrP gene expression in association with serum corticosterone suppression.	Corticosterone	57-71	parathyroid hormone-like hormone	Rattus norvegicus	152-157
8137762-10	1994	PTHrP suppression by stress is caused by the increase in corticosterone, as pretreatment of metyrapone, an inhibitor of 11 beta-hydroxylation, enhanced PTHrP gene expression in association with serum corticosterone suppression.	Corticosterone	200-214	parathyroid hormone-like hormone	Rattus norvegicus	0-5
8137762-11	1994	In conclusion, PTHrP might be an important gastrointestinal peptide that regulates gastric contractile activity and is influenced by the serum corticosterone level.	Corticosterone	143-157	parathyroid hormone-like hormone	Rattus norvegicus	15-20
8014601-10	1994	Functional studies of adrenals cultured in vitro revealed that acd/acd adrenals secreted reduced amounts of corticosterone per pair of glands under both basal and ACTH-stimulated conditions.	Corticosterone	108-122	adrenocortical dysplasia	Mus musculus	63-66
8014601-10	1994	Functional studies of adrenals cultured in vitro revealed that acd/acd adrenals secreted reduced amounts of corticosterone per pair of glands under both basal and ACTH-stimulated conditions.	Corticosterone	108-122	adrenocortical dysplasia	Mus musculus	67-70
8180111-2	1994	VIP dose-dependently increased basal, but not submaximally ACTH (10(-10) M)-stimulated, aldosterone (ALDO) and corticosterone (B) secretion of dispersed rat capsular and inner adrenocortical cells, respectively.	Corticosterone	111-125	vasoactive intestinal peptide	Rattus norvegicus	0-3
8202220-4	1994	Chronic replacement with moderate doses of corticosterone restored the fever response in adrenalectomized animals in response to icv administration of IL-1 beta but only partially reversed the fever caused by IL-6.	Corticosterone	43-57	interleukin 1 beta	Rattus norvegicus	151-160
8202220-4	1994	Chronic replacement with moderate doses of corticosterone restored the fever response in adrenalectomized animals in response to icv administration of IL-1 beta but only partially reversed the fever caused by IL-6.	Corticosterone	43-57	interleukin 6	Rattus norvegicus	209-213
8202220-6	1994	In intact animals corticosterone blocked the fever response to icv injected IL-1 beta.	Corticosterone	18-32	interleukin 1 beta	Rattus norvegicus	76-85
8004437-0	1994	Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	26-57
8004437-1	1994	Using in situ hybridization histochemistry, we report differential expression of corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA) and the parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following systemic treatment with corticosterone (CORT) in adrenally-intact rats.	Corticosterone	289-303	corticotropin releasing hormone	Rattus norvegicus	81-112
8004437-1	1994	Using in situ hybridization histochemistry, we report differential expression of corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA) and the parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following systemic treatment with corticosterone (CORT) in adrenally-intact rats.	Corticosterone	289-303	corticotropin releasing hormone	Rattus norvegicus	114-117
8004437-1	1994	Using in situ hybridization histochemistry, we report differential expression of corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA) and the parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following systemic treatment with corticosterone (CORT) in adrenally-intact rats.	Corticosterone	305-309	corticotropin releasing hormone	Rattus norvegicus	81-112
8004437-1	1994	Using in situ hybridization histochemistry, we report differential expression of corticotropin-releasing hormone (CRH) mRNA in the central nucleus of the amygdala (CEA) and the parvocellular region of the paraventricular nucleus of the hypothalamus (PVN) following systemic treatment with corticosterone (CORT) in adrenally-intact rats.	Corticosterone	305-309	corticotropin releasing hormone	Rattus norvegicus	114-117
8015378-6	1994	(4) Corticosterone administration prevented adrenalectomy effects on hippocampal adenylate cyclase activity and calmodulin mRNA levels.	Corticosterone	4-18	calmodulin 1	Rattus norvegicus	112-122
7489323-0	1994	Rapid increase in plasma IL-6 after hemorrhage, and posthemorrhage reduction of the IL-6 response to LPS, in conscious rats: interrelation with plasma corticosterone levels.	Corticosterone	151-165	interleukin 6	Rattus norvegicus	25-29
7489323-4	1994	In adrenalectomized (ADX) rats with or without a corticosterone pellet implant, there was an inverse relationship between IL-6 and corticosterone concentrations, greatest in ADX rats and lowest in ADX rats in which plasma corticosterone was elevated by crushing the implanted pellet.	Corticosterone	49-63	interleukin 6	Rattus norvegicus	122-126
7489323-4	1994	In adrenalectomized (ADX) rats with or without a corticosterone pellet implant, there was an inverse relationship between IL-6 and corticosterone concentrations, greatest in ADX rats and lowest in ADX rats in which plasma corticosterone was elevated by crushing the implanted pellet.	Corticosterone	131-145	interleukin 6	Rattus norvegicus	122-126
7489323-4	1994	In adrenalectomized (ADX) rats with or without a corticosterone pellet implant, there was an inverse relationship between IL-6 and corticosterone concentrations, greatest in ADX rats and lowest in ADX rats in which plasma corticosterone was elevated by crushing the implanted pellet.	Corticosterone	131-145	interleukin 6	Rattus norvegicus	122-126
7489323-5	1994	However, the ADX rats in which plasma corticosterone was maintained at normal or slightly elevated levels showed greater IL-6 responses to hemorrhage and elevated basal plasma IL-6 levels compared to sham-operated control rats.	Corticosterone	38-52	interleukin 6	Rattus norvegicus	121-125
7489323-5	1994	However, the ADX rats in which plasma corticosterone was maintained at normal or slightly elevated levels showed greater IL-6 responses to hemorrhage and elevated basal plasma IL-6 levels compared to sham-operated control rats.	Corticosterone	38-52	interleukin 6	Rattus norvegicus	176-180
7489323-8	1994	Although very high plasma corticosterone concentrations markedly suppressed the IL-6 response to LPS, in ADX rats in which plasma corticosterone was maintained at slightly higher levels than normal, the reduced IL-6 response to LPS in the posthemorrhage period was not reversed, but enhanced.	Corticosterone	26-40	interleukin 6	Rattus norvegicus	80-84
7489323-9	1994	Thus corticosterone has biphasic effects on the IL-6 response to hemorrhage and the response to LPS during the posthemorrhage period, which has important clinical implications with regard to the optimal dose of glucocorticoid for maintaining the host defense response.	Corticosterone	5-19	interleukin 6	Rattus norvegicus	48-52
7838929-7	1994	Taken together, this evidence is compatible with a specific corticosterone induced facilitation of 5-HT release due to attenuation of inhibitory 5-HT1A autoreceptor function.	Corticosterone	60-74	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	145-151
8123004-2	1994	The classical rat 11 beta-hydroxylase or CYP11B1 enzyme hydroxylates deoxycorticosterone to corticosterone and 18-hydroxydeoxycorticosterone and is located throughout the adrenal.	Corticosterone	74-88	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	41-48
8123004-3	1994	The second aldosterone synthase or CYP11B2 enzyme is located in the zona glomerulosa and converts deoxycorticosterone to corticosterone, 18-hydroxycorticosterone and aldosterone.	Corticosterone	103-117	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	11-31
8123004-3	1994	The second aldosterone synthase or CYP11B2 enzyme is located in the zona glomerulosa and converts deoxycorticosterone to corticosterone, 18-hydroxycorticosterone and aldosterone.	Corticosterone	103-117	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	35-42
8123004-6	1994	The hybrid CYPH11B1 construct containing the first 5 exons of the CYP11B1 when expressed, retains 11 beta-hydroxylase activity, but cannot process corticosterone to 18-hydroxycorticosterone or aldosterone.	Corticosterone	147-161	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	66-73
8013547-3	1994	CV-11974 had no effect on adrenocorticotropic hormone-stimulated aldosterone or corticosterone production, but inhibited angiotensin II-stimulated corticosterone production.	Corticosterone	147-161	angiotensinogen	Rattus norvegicus	121-135
8174225-3	1994	The effects of glucocorticoids in the hippocampus are elicited through two receptors with high-affinity for corticosterone, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	128-151
8174225-3	1994	The effects of glucocorticoids in the hippocampus are elicited through two receptors with high-affinity for corticosterone, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	153-155
8174225-3	1994	The effects of glucocorticoids in the hippocampus are elicited through two receptors with high-affinity for corticosterone, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	165-191
8174225-3	1994	The effects of glucocorticoids in the hippocampus are elicited through two receptors with high-affinity for corticosterone, the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR).	Corticosterone	108-122	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	193-195
8141396-5	1994	In contrast to tissue NE turnover, plasma corticosterone level was increased after the administration of IL-6 as well as IL-1, regardless of the site of administration.	Corticosterone	42-56	interleukin 6	Rattus norvegicus	105-109
8141398-6	1994	The increase in corticosterone was abolished not by the SPX but by pretreatment with anti-CRF antibody.	Corticosterone	16-30	spexin hormone	Rattus norvegicus	56-59
8299577-12	1994	Both Dex and Cort caused a dose-dependent increase in TRH accumulation, but Cort was approximately 40 times less potent than Dex.	Corticosterone	13-17	thyrotropin releasing hormone	Rattus norvegicus	54-57
8188945-7	1994	Prolactin increased alpha-lactalbumin accumulation to a similar extent alone, or in the presence of insulin and/or corticosterone.	Corticosterone	115-129	prolactin	Sus scrofa	0-9
8188945-11	1994	By contrast, no specific hormonal requirements were established for accumulation of beta-lactoglobulin, which appeared to increase in vitro if tissue remained viable in various combinations of insulin, corticosterone and prolactin.	Corticosterone	202-216	progestagen associated endometrial protein	Sus scrofa	84-102
8127410-8	1994	Power spectral analysis showed significant periodicities in corticosterone secretion rate in individual CTRL and SPLNX animals at 1, 2, and 5 days.	Corticosterone	60-74	chymotrypsin-like	Rattus norvegicus	104-108
8191550-9	1994	The glucocorticoid receptor blocker, RU 486, prevented inhibition by both corticosterone and dexamethasone.	Corticosterone	74-88	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	4-27
8054402-7	1994	Our results suggest that rCRF or AVP alone and rCRF in association with AVP or OT injected intravenously in the fetal rat produced a selective release of the molecular ACTH forms and the increase in the plasma corticosterone concentration occurred when the proportion of little ACTH which is the predominant ACTH form in the fetal rat was enhanced.	Corticosterone	210-224	corticotropin releasing hormone	Rattus norvegicus	25-29
8054402-7	1994	Our results suggest that rCRF or AVP alone and rCRF in association with AVP or OT injected intravenously in the fetal rat produced a selective release of the molecular ACTH forms and the increase in the plasma corticosterone concentration occurred when the proportion of little ACTH which is the predominant ACTH form in the fetal rat was enhanced.	Corticosterone	210-224	corticotropin releasing hormone	Rattus norvegicus	47-51
8164522-2	1994	To test the hypothesis that endogenous NPY is essential for the normal expression of these responses, the present study used to unmodified antisense oligodeoxynucleotides (ODNs) to disrupt the synthesis of NPY in the ARC and to examine the impact of this disturbance on nutrient intake, as well as on circulating levels of insulin and the adrenal steroids, corticosterone and aldosterone.	Corticosterone	357-371	neuropeptide Y	Rattus norvegicus	39-42
8275929-0	1994	Corticosterone in vivo increases pituitary follicle-stimulating hormone (FSH)-beta messenger ribonucleic acid content and serum FSH bioactivity selectively in female rats.	Corticosterone	0-14	follicle stimulating hormone subunit beta	Rattus norvegicus	43-82
8275929-1	1994	Experimental objectives were to determine: 1) if the native glucocorticoid, corticosterone (B), can selectively increase pituitary FSH and FSH beta messenger RNA (mRNA) in the presence or absence of a GnRH signal; and 2) if B affects the biological activity of the gonadotropins.	Corticosterone	76-90	follicle stimulating hormone subunit beta	Rattus norvegicus	139-147
8275929-11	1994	These results demonstrate that corticosterone can increase biological activity of secreted FSH and increase FSH beta mRNA in the absence of a GnRH signal, suggesting a direct effect on the anterior pituitary gland.	Corticosterone	31-45	follicle stimulating hormone subunit beta	Rattus norvegicus	108-116
8159284-0	1994	The role of central corticoliberin in the ether stress-induced secretion of neurohypophyseal hormones and corticosterone in the rat.	Corticosterone	106-120	corticotropin releasing hormone	Rattus norvegicus	20-34
8159286-3	1994	The lower dose of NMU-8 did not change blood ACTH concentration and adrenal weight, but it notably enhanced serum corticosterone level and basal corticosterone output by adrenal slices.	Corticosterone	114-128	neuromedin U	Rattus norvegicus	18-21
8159286-3	1994	The lower dose of NMU-8 did not change blood ACTH concentration and adrenal weight, but it notably enhanced serum corticosterone level and basal corticosterone output by adrenal slices.	Corticosterone	145-159	neuromedin U	Rattus norvegicus	18-21
8159286-7	1994	NMU-8 (10(-8) M) markedly raised basal corticosterone secretion by adrenal slices (including cortex and medulla); higher concentrations of NMU-8 (10(-7)/10(-6) M) were ineffective on basal corticosterone secretion, but strongly inhibited the response to ACTH stimulation.	Corticosterone	39-53	neuromedin U	Rattus norvegicus	0-3
8159286-7	1994	NMU-8 (10(-8) M) markedly raised basal corticosterone secretion by adrenal slices (including cortex and medulla); higher concentrations of NMU-8 (10(-7)/10(-6) M) were ineffective on basal corticosterone secretion, but strongly inhibited the response to ACTH stimulation.	Corticosterone	189-203	neuromedin U	Rattus norvegicus	0-3
8165156-6	1994	Corticosterone concentrations in response to both 10(-6) and 10(-5) ACTH were significantly lower for BSX than for sham ACC.	Corticosterone	0-14	proopiomelanocortin	Homo sapiens	68-72
7527566-9	1994	ICV injections of TRH caused dose-dependent increases in plasma CS, but did not further increase HPA responses when injected together with 5-HT.	Corticosterone	64-66	thyrotropin releasing hormone	Rattus norvegicus	18-21
7527566-14	1994	Intra-PVN injections of 5-HT (0.1 or 40 nmol) and TRH also increased plasma CS concentrations.	Corticosterone	76-78	thyrotropin releasing hormone	Rattus norvegicus	50-53
7862863-0	1994	Time course of the effects of adrenalectomy and corticosterone replacement on 5-HT1A receptors and 5-HT uptake sites in the hippocampus and dorsal raphe nucleus of the rat brain: an autoradiographic analysis.	Corticosterone	48-62	5-hydroxytryptamine receptor 1A	Rattus norvegicus	78-84
7862863-1	1994	Previous studies have shown that adrenalectomy (ADX) increases the binding of 3H-DPAT to 5-HT1A receptors in the hippocampus (HIP) and this effect is partially overcome by corticosterone (CORT) replacement.	Corticosterone	172-186	5-hydroxytryptamine receptor 1A	Rattus norvegicus	89-95
7862863-1	1994	Previous studies have shown that adrenalectomy (ADX) increases the binding of 3H-DPAT to 5-HT1A receptors in the hippocampus (HIP) and this effect is partially overcome by corticosterone (CORT) replacement.	Corticosterone	172-186	cortistatin	Rattus norvegicus	188-192
8190832-7	1994	Administration of IL-1 produces a long-lasting increase in corticosterone.	Corticosterone	59-73	interleukin 1 alpha	Homo sapiens	18-22
8190836-4	1994	Bioactive concentrations of interleukin-6 (IL-6) in plasma rose markedly after turpentine, and its concentrations were significantly correlated with plasma corticosterone concentrations 4-8 h after turpentine.	Corticosterone	156-170	interleukin 6	Rattus norvegicus	28-41
8190836-4	1994	Bioactive concentrations of interleukin-6 (IL-6) in plasma rose markedly after turpentine, and its concentrations were significantly correlated with plasma corticosterone concentrations 4-8 h after turpentine.	Corticosterone	156-170	interleukin 6	Rattus norvegicus	43-47
8190836-5	1994	Pretreatment with IL-1 receptor antagonist (IL-1ra) attenuated the release of IL-6 and had a marginal effect on the corticosterone response 6 h after turpentine.	Corticosterone	116-130	interleukin 1 receptor antagonist	Rattus norvegicus	18-42
8190836-5	1994	Pretreatment with IL-1 receptor antagonist (IL-1ra) attenuated the release of IL-6 and had a marginal effect on the corticosterone response 6 h after turpentine.	Corticosterone	116-130	interleukin 1 receptor antagonist	Rattus norvegicus	44-50
8136039-6	1993	Basal corticosterone (CORT) levels were sharply higher, and plasma testosterone (T) sharply lower, in subordinates compared to both dominants and controls, and reduced corticosterone binding globulin further enhanced free CORT for subordinates particularly.	Corticosterone	6-20	cortistatin	Rattus norvegicus	22-26
7535427-1	1994	The peptide galanin (GAL), when injected into the rat hypothalamus, is known to stimulate feeding behavior and affect the secretion of various hormones, including insulin and the adrenal steroid, corticosterone.	Corticosterone	196-210	galanin and GMAP prepropeptide	Rattus norvegicus	12-19
7535427-1	1994	The peptide galanin (GAL), when injected into the rat hypothalamus, is known to stimulate feeding behavior and affect the secretion of various hormones, including insulin and the adrenal steroid, corticosterone.	Corticosterone	196-210	galanin and GMAP prepropeptide	Rattus norvegicus	21-24
8136039-6	1993	Basal corticosterone (CORT) levels were sharply higher, and plasma testosterone (T) sharply lower, in subordinates compared to both dominants and controls, and reduced corticosterone binding globulin further enhanced free CORT for subordinates particularly.	Corticosterone	168-182	cortistatin	Rattus norvegicus	222-226
8279536-3	1993	Substitution of ADX rats with subcutaneously implanted 12.5-mg corticosterone (Cort) pellets, which resulted in low circulating Cort levels (17 +/- 3 nM), restored the reduced proliferative capacity to that of sham-ADX animals.	Corticosterone	63-77	cortistatin	Rattus norvegicus	79-83
8279536-3	1993	Substitution of ADX rats with subcutaneously implanted 12.5-mg corticosterone (Cort) pellets, which resulted in low circulating Cort levels (17 +/- 3 nM), restored the reduced proliferative capacity to that of sham-ADX animals.	Corticosterone	63-77	cortistatin	Rattus norvegicus	128-132
8243274-5	1993	Interestingly, the kinetics of the increase in plasma IL-6 resembled that of increase in plasma corticosterone.	Corticosterone	96-110	interleukin 6	Rattus norvegicus	54-58
8293296-1	1993	Pyramidal neurons in the rat CA1 hippocampal area contain membrane receptors for acetylcholine but also intracellular receptors for the adrenal corticosteroid hormone corticosterone, i.e., mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs).	Corticosterone	167-181	carbonic anhydrase 1	Rattus norvegicus	29-32
7694841-8	1993	ADNX prevented these effects of STZ-diabetes, and corticosterone treatment restored serum IGF-binding activity and IGFBP-1 to intact diabetic levels.	Corticosterone	50-64	insulin-like growth factor binding protein 1	Rattus norvegicus	115-122
7694841-10	1993	Corticosterone treatment restored hepatic IGFBP-1 mRNA to intact diabetic levels, and serum concentrations of corticosterone correlated with the abundance of IGFBP-1 mRNA (r = 0.475; P &lt; 0.01), indicating that glucocorticoids play an important role in the regulation of expression of IGFBP-1 in insulin-deficient animals.	Corticosterone	0-14	insulin-like growth factor binding protein 1	Rattus norvegicus	42-49
7694841-13	1993	Of note, serum levels of IGF-I by RIA were reduced in STZ-diabetic animals compared to control values (168 +/- 16 vs. 587 +/- 55 ng/ml, respectively; P &lt; 0.01), were partially restored toward control values with ADNX (320 +/- 22 ng/ml), and were reduced again by corticosterone treatment (195 +/- 26 ng/ml), indicating that glucocorticoids also contribute to the regulation of IGF-I levels in insulin-deficient animals.	Corticosterone	266-280	insulin-like growth factor 1	Rattus norvegicus	25-30
8254032-4	1993	The anti-TNF treatment was also effective in attenuating early perturbations in insulin and corticosterone homeostasis.	Corticosterone	92-106	tumor necrosis factor	Rattus norvegicus	9-12
8277328-12	1993	Measurement of corticosterone in the sera of these animals showed that changes in lipocortin 1 immunostaining in the CNS during EAE closely parallel serum corticosterone levels.	Corticosterone	15-29	annexin A1	Rattus norvegicus	82-94
8277328-12	1993	Measurement of corticosterone in the sera of these animals showed that changes in lipocortin 1 immunostaining in the CNS during EAE closely parallel serum corticosterone levels.	Corticosterone	155-169	annexin A1	Rattus norvegicus	82-94
8302237-5	1993	Corticosterone secretion from adrenal cell cultures treated with ACTH from basal or CRH stimulated pituitary cell cultures exposed to TCDD was decreased by 60 and 70%, respectively.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	84-87
8309791-16	1993	(d) A change of the side-group in position 11 of corticosterone from -OH to -H to = O enhances interaction with the PAH transporter but has no effect on the interaction with the TEA transporter.	Corticosterone	49-63	solute carrier family 22 member 6	Homo sapiens	116-131
8279659-0	1993	Effect of exposure to an alcohol diet for 10 days on the ability of interleukin-1 beta to release ACTH and corticosterone in the adult ovariectomized female rat.	Corticosterone	107-121	interleukin 1 beta	Rattus norvegicus	68-86
8242262-13	1993	Similarly, treatment with anti-murine TNF alpha monoclonal antibody (mAb) abrogated TNF activity without affecting corticosterone, suggesting that other mediators may be responsible for corticosterone release following LPS.	Corticosterone	186-200	tumor necrosis factor	Rattus norvegicus	38-47
8261610-1	1993	Twenty-four hours of maternal separation results in increased secretion of ACTH and corticosterone (CORT), suggesting the hypothalamic-pituitary-adrenal (HPA) axis is regulated by some aspect of maternal behavior.	Corticosterone	84-98	cortistatin	Homo sapiens	100-104
8242262-13	1993	Similarly, treatment with anti-murine TNF alpha monoclonal antibody (mAb) abrogated TNF activity without affecting corticosterone, suggesting that other mediators may be responsible for corticosterone release following LPS.	Corticosterone	186-200	tumor necrosis factor	Rattus norvegicus	38-41
8403498-5	1993	To examine further mechanisms responsible for suppression, we determined the level of plasma corticosterone in response to IL-1 alpha in Lewis, F344 and GF F344 rats.	Corticosterone	93-107	interleukin 1 alpha	Rattus norvegicus	123-133
8403498-6	1993	IL-1 alpha induced only low amounts of corticosterone in Lewis rats, but high amounts in both F344 and GF F344 rats.	Corticosterone	39-53	interleukin 1 alpha	Rattus norvegicus	0-10
8404624-6	1993	Steroids that bound to CBG, e.g. corticosterone and cortisol, noncompetitively inhibited CBG"s binding to the receptor.	Corticosterone	33-47	serpin family A member 6	Rattus norvegicus	23-26
8404624-6	1993	Steroids that bound to CBG, e.g. corticosterone and cortisol, noncompetitively inhibited CBG"s binding to the receptor.	Corticosterone	33-47	serpin family A member 6	Rattus norvegicus	89-92
8276442-1	1993	Induced chronic hypocorticalism by dexamethasone (DXM) and hypercorticalism by corticosterone (CORT) retarded body weight gain as well as the growth of spleen, bursa, liver, kidney and pancreas during the first month of development in male leghorn chicks.	Corticosterone	79-93	cortistatin	Homo sapiens	95-99
8243867-6	1993	GLUT4 protein and mRNA levels were either unchanged or slightly increased by corticosterone administration.	Corticosterone	77-91	solute carrier family 2 member 4	Rattus norvegicus	0-5
8229762-11	1993	The glucocorticoid receptor antagonist RU 486 was used to block the actions of corticosterone and investigate its possible role in morphine sulfate-induced suppression of phagocytosis.	Corticosterone	79-93	nuclear receptor subfamily 3, group C, member 1	Mus musculus	4-27
8412753-1	1993	The 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) activity of the kidney prevents access of cortisol or corticosterone to the renal mineralocorticoid receptor.	Corticosterone	109-123	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	137-163
8312138-5	1993	For example, 0.1 nM ACTH stimulates steroid secretion by three-fold in isolated cells while 1 pM ACTH already induces a 25 and nine-fold increase, respectively, in corticosterone and aldosterone output in cultured cells.	Corticosterone	164-178	proopiomelanocortin	Homo sapiens	20-24
8680422-6	1993	These data suggest that intermediate levels of corticosterone are necessary to maintain the stability of the Schaffer collateral input to CA1 neurons.	Corticosterone	47-61	carbonic anhydrase 1	Rattus norvegicus	138-141
8680422-7	1993	With very low or high corticosterone levels, CA1 neurons apparently fail to respond to synaptic stimulation, over time.	Corticosterone	22-36	carbonic anhydrase 1	Rattus norvegicus	45-48
8117933-8	1993	In the 3 strains, Il-1 alpha induced ACTH and IL-1 alpha and beta induced corticosterone responses, nearly 2-fold higher in females than in males.	Corticosterone	74-88	interleukin 1 alpha	Mus musculus	18-28
8365361-0	1993	Gene expression and serum thyroxine-binding globulin are regulated by adrenal status and corticosterone in the rat.	Corticosterone	89-103	serpin family A member 7	Rattus norvegicus	26-52
8365361-3	1993	The serum TBG-binding capacity was 14.9 +/- 2.3 nmol/liter in adrenalectomized male rats compared to 6.6 +/- 1.0 nmol/liter in intact male rats and 4.8 +/- 0.9 nmol/liter in adrenalectomized male rats that received corticosterone in a dose equal to or less than the replacement dose, as assessed by thymus weight (P &lt; 0.01 for serum TBG in adrenalectomized vs. intact or adrenalectomized corticosterone-treated groups).	Corticosterone	215-229	serpin family A member 7	Rattus norvegicus	10-13
8365361-3	1993	The serum TBG-binding capacity was 14.9 +/- 2.3 nmol/liter in adrenalectomized male rats compared to 6.6 +/- 1.0 nmol/liter in intact male rats and 4.8 +/- 0.9 nmol/liter in adrenalectomized male rats that received corticosterone in a dose equal to or less than the replacement dose, as assessed by thymus weight (P &lt; 0.01 for serum TBG in adrenalectomized vs. intact or adrenalectomized corticosterone-treated groups).	Corticosterone	391-405	serpin family A member 7	Rattus norvegicus	10-13
8365361-4	1993	Hepatic TBG mRNA content, as assessed by polymerase chain reaction amplification and expressed as a ratio of beta-actin mRNA content, was 0.10 +/- 0.03 density units in intact male rats, 0.59 +/- 0.17 density units in adrenalectomized male rats, and 0.05 +/- 0.02 density units in adrenalectomized corticosterone-treated male rats (P &lt; 0.03 for adrenalectomized vs. intact or adrenalectomized corticosterone-treated rats).	Corticosterone	298-312	serpin family A member 7	Rattus norvegicus	8-11
8365361-4	1993	Hepatic TBG mRNA content, as assessed by polymerase chain reaction amplification and expressed as a ratio of beta-actin mRNA content, was 0.10 +/- 0.03 density units in intact male rats, 0.59 +/- 0.17 density units in adrenalectomized male rats, and 0.05 +/- 0.02 density units in adrenalectomized corticosterone-treated male rats (P &lt; 0.03 for adrenalectomized vs. intact or adrenalectomized corticosterone-treated rats).	Corticosterone	396-410	serpin family A member 7	Rattus norvegicus	8-11
8365361-6	1993	These studies indicate that serum TBG is tonically down-regulated by adrenal glucocorticoids, because corticosterone decreases the TBG production rate, probably at the level of transcription.	Corticosterone	102-116	serpin family A member 7	Rattus norvegicus	34-37
8365361-6	1993	These studies indicate that serum TBG is tonically down-regulated by adrenal glucocorticoids, because corticosterone decreases the TBG production rate, probably at the level of transcription.	Corticosterone	102-116	serpin family A member 7	Rattus norvegicus	131-134
8365361-7	1993	This effect is similar to that described for corticosterone-binding globulin, but differs from that for many proteins of the serine protease inhibitor family that are related to TBG.	Corticosterone	45-59	serpin family A member 7	Rattus norvegicus	178-181
8397087-2	1993	In the rabbit, six NPs, i.e., NP-1, -2, -3A, -3B, -4, and -5, have been isolated, among them, NP-3A has the most potent corticostatic activity, which involves the inhibition of adrenocorticotropin-stimulated corticosterone synthesis in adrenal cells.	Corticosterone	208-222	corticostatin-3	Oryctolagus cuniculus	30-60
7903945-1	1993	The activity of the rate-limiting enzyme of catecholamine synthesis--the tyrosine hydroxylase (TH) increased in the brain of 20-day-old fetuses of the Wistar strain and aggressive gray rats, 6 hours after corticosterone injection to their mothers.	Corticosterone	205-219	tyrosine hydroxylase	Rattus norvegicus	73-93
7903945-1	1993	The activity of the rate-limiting enzyme of catecholamine synthesis--the tyrosine hydroxylase (TH) increased in the brain of 20-day-old fetuses of the Wistar strain and aggressive gray rats, 6 hours after corticosterone injection to their mothers.	Corticosterone	205-219	tyrosine hydroxylase	Rattus norvegicus	95-97
7903945-3	1993	Corticosterone injection to the females of these strains on the 16th and 18th days of pregnancy caused inhibition of the fetal development within 3 days, assessed by measuring the fetal body weight, and alterations in the TH activity of the fetal brain.	Corticosterone	0-14	tyrosine hydroxylase	Rattus norvegicus	222-224
8312138-5	1993	For example, 0.1 nM ACTH stimulates steroid secretion by three-fold in isolated cells while 1 pM ACTH already induces a 25 and nine-fold increase, respectively, in corticosterone and aldosterone output in cultured cells.	Corticosterone	164-178	proopiomelanocortin	Homo sapiens	97-101
8360772-0	1993	Corticosterone enhances the zinc and interleukin-6-mediated induction of metallothionein in cultured rat hepatocytes.	Corticosterone	0-14	interleukin 6	Rattus norvegicus	37-50
8241531-6	1993	The rise in the corticosterone level induced by clonidine was significantly diminished by mepyramine, a histamine H1-receptor antagonist, and moderately lowered by cimetidine, a histamine H2-receptor antagonist.	Corticosterone	16-30	histamine receptor H 1	Rattus norvegicus	104-125
8241531-6	1993	The rise in the corticosterone level induced by clonidine was significantly diminished by mepyramine, a histamine H1-receptor antagonist, and moderately lowered by cimetidine, a histamine H2-receptor antagonist.	Corticosterone	16-30	histamine receptor H 2	Rattus norvegicus	178-199
8360772-13	1993	The results demonstrate that concentrations of corticosterone in rats with experimental inflammation facilitate metallothionein induction with Zn and interleukin-6.	Corticosterone	47-61	interleukin 6	Rattus norvegicus	150-163
8360772-6	1993	Like dexamethasone, corticosterone had a dose dependent effect on metallothionein and synergy with Zn and Zn+interleukin-6.	Corticosterone	20-34	interleukin 6	Rattus norvegicus	109-122
8360772-8	1993	Physiological concentrations of corticosterone (1 mumol/L) when added alone, with Zn (10 mumol/L), and with Zn+interleukin-6 resulted in inductions of 2.2, 5.0 and 7.4-fold above the control cultures.	Corticosterone	32-46	interleukin 6	Rattus norvegicus	111-124
8243546-2	1993	In vivo, they both dose dependently blocked the flat-body posture and corticosterone secretion provoked by an action of the 5-HT1A receptor agonist, S 14671 (1-[2-(2-thenoyl-amino)ethyl]-4-[1-(7- methoxynaphtyl)]piperazine), at postsynaptic 5-HT1A receptors.	Corticosterone	70-84	5-hydroxytryptamine receptor 1A	Homo sapiens	124-139
8396170-4	1993	Lesions of the MpFC (cingulate gyrus) significantly increased plasma levels of both adrenocorticotropin (ACTH) and corticosterone (CORT) in response to a 20 min restraint stress.	Corticosterone	115-129	cortistatin	Rattus norvegicus	131-135
8243546-2	1993	In vivo, they both dose dependently blocked the flat-body posture and corticosterone secretion provoked by an action of the 5-HT1A receptor agonist, S 14671 (1-[2-(2-thenoyl-amino)ethyl]-4-[1-(7- methoxynaphtyl)]piperazine), at postsynaptic 5-HT1A receptors.	Corticosterone	70-84	5-hydroxytryptamine receptor 1A	Homo sapiens	124-130
8348265-3	1993	Corticosterone (B) replacement in adrenalectomized (ADX) animals resulted in a dose-dependent reduction in pituitary IL-6 mRNA accumulation, while in ADX plus AA animals these effects of B were less marked.	Corticosterone	0-14	interleukin 6	Rattus norvegicus	117-121
8368299-6	1993	Resting plasma corticosterone concentrations were significantly elevated in the aged and adult mice, whereas injection of mIL-1 beta significantly raised plasma corticosterone concentrations in all animals.	Corticosterone	161-175	interleukin 1 beta	Mus musculus	122-132
8264866-1	1993	Intravenous injection of nerve growth factor (NGF) into rats produces a dose-dependent (from 0.1 to 5 nmol/kg) increase in circulating concentrations of adrenocorticotropin (ACTH) and corticosterone.	Corticosterone	184-198	nerve growth factor	Rattus norvegicus	25-44
8264866-1	1993	Intravenous injection of nerve growth factor (NGF) into rats produces a dose-dependent (from 0.1 to 5 nmol/kg) increase in circulating concentrations of adrenocorticotropin (ACTH) and corticosterone.	Corticosterone	184-198	nerve growth factor	Rattus norvegicus	46-49
8264867-9	1993	Intravenous injection of polyclonal corticotropin-releasing hormone (CRH) Ab resulted in a decrease of plasma adrenocorticotropin and corticosterone levels.	Corticosterone	134-148	corticotropin releasing hormone	Rattus norvegicus	36-67
8264867-9	1993	Intravenous injection of polyclonal corticotropin-releasing hormone (CRH) Ab resulted in a decrease of plasma adrenocorticotropin and corticosterone levels.	Corticosterone	134-148	corticotropin releasing hormone	Rattus norvegicus	69-72
8371831-7	1993	The binding of [125I]calmodulin to the synaptic membrane was found to be increased by corticosterone (10(-7)-10(-6) M), a steroid hormone, and decreased by ethanol (50-200 mM), a centrally acting drug.	Corticosterone	86-100	calmodulin 1	Rattus norvegicus	21-31
8413859-0	1993	Unusual effect of prolonged vasoactive intestinal peptide (VIP) administration on the adrenal growth and corticosterone secretion in the rat.	Corticosterone	105-119	vasoactive intestinal peptide	Rattus norvegicus	28-57
8413859-0	1993	Unusual effect of prolonged vasoactive intestinal peptide (VIP) administration on the adrenal growth and corticosterone secretion in the rat.	Corticosterone	105-119	vasoactive intestinal peptide	Rattus norvegicus	59-62
8413859-6	1993	After standardized ether stress, blood corticosterone concentration was similar in control and 14-day VIP-treated rats, while corticosterone secretion by adrenal quarters was higher in VIP-administered animals.	Corticosterone	126-140	vasoactive intestinal peptide	Rattus norvegicus	185-188
8413859-7	1993	Thus, prolonged VIP administration results in an unusual inhibition of corticosterone secretion in the rat, which is not coupled with a compensatory hypertrophy of the rat adrenal cortex.	Corticosterone	71-85	vasoactive intestinal peptide	Rattus norvegicus	16-19
8372133-1	1993	Plasma corticosterone (CORT) and aldosterone (ALDO) exhibit diurnal rhythmicity.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
8335906-6	1993	Serum levels of corticosterone were elevated but were within a similar range among the transplant recipients destined for acute rejection, those undergoing ACR, and isografted controls, suggesting the participation of mediator(s) other than glucocorticoid in the induction of extensive apoptosis in the transplant recipients with ACR.	Corticosterone	16-30	acrosin	Rattus norvegicus	156-159
8335906-6	1993	Serum levels of corticosterone were elevated but were within a similar range among the transplant recipients destined for acute rejection, those undergoing ACR, and isografted controls, suggesting the participation of mediator(s) other than glucocorticoid in the induction of extensive apoptosis in the transplant recipients with ACR.	Corticosterone	16-30	acrosin	Rattus norvegicus	330-333
8372607-6	1993	In mammals, prolactin is associated with learning, stimulation of the immune response, reduction of body temperature and increased corticosterone secretion.	Corticosterone	131-145	prolactin	Homo sapiens	12-21
8338156-4	1993	Administration of corticosterone (500 micrograms.100 g body wt-1.day-1 sc) to intact or adrenalectomized rats, kept at 28 degrees C, produced a marked decrease of UCP mitochondrial content and cellular mRNA levels in a time-dependent manner (30% by 12 h and 50% by 24 h).	Corticosterone	18-32	uncoupling protein 1	Rattus norvegicus	163-166
8338156-5	1993	Pretreatment of intact rats with corticosterone virtually abolished the UCP mRNA response to cold and norepinephrine (NE).	Corticosterone	33-47	uncoupling protein 1	Rattus norvegicus	72-75
8338156-7	1993	These results show that corticosterone is a powerful inhibitor of UCP gene expression in vivo.	Corticosterone	24-38	uncoupling protein 1	Rattus norvegicus	66-69
8338156-9	1993	The data further suggest that corticosterone inhibits the initial accumulation of UCP mRNA mediated by UCP gene transcription, rather than accelerating the degradation of UCP mRNA.	Corticosterone	30-44	uncoupling protein 1	Rattus norvegicus	82-85
8338156-9	1993	The data further suggest that corticosterone inhibits the initial accumulation of UCP mRNA mediated by UCP gene transcription, rather than accelerating the degradation of UCP mRNA.	Corticosterone	30-44	uncoupling protein 1	Rattus norvegicus	103-106
8338156-9	1993	The data further suggest that corticosterone inhibits the initial accumulation of UCP mRNA mediated by UCP gene transcription, rather than accelerating the degradation of UCP mRNA.	Corticosterone	30-44	uncoupling protein 1	Rattus norvegicus	103-106
8400179-4	1993	The correlation of corticosterone/insulin ratio was directly proportional in LHR rats and inversely proportional in HHR rats.	Corticosterone	19-33	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	77-80
8319565-4	1993	This rise in FFA was associated with a 2- to 3-fold increase in the binding indices (C values; liters per g) of corticosterone (B) and progesterone to CBG 60-120 min postinjection (P &lt; 0.001).	Corticosterone	112-126	serpin family A member 6	Rattus norvegicus	151-154
8414172-1	1993	This study was designed to assess the involvement of corticotropin-releasing factor (CRF) in the corticosterone response to the acute administration of the serotonergic indirect agonist D-fenfluramine in the rat.	Corticosterone	97-111	corticotropin releasing hormone	Rattus norvegicus	53-83
8392808-1	1993	In the rat kidney 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) maintains normal in vivo specificity for mineralocorticoid receptor (MR) by converting the active steroid corticosterone to inactive 11-dehydrocorticosterone, leaving aldosterone to occupy the MR. Clinical observations support the hypothesis that 11 beta-HSD also protects the distal colonic MR from glucocorticoid excess.	Corticosterone	175-189	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	110-136
8392808-1	1993	In the rat kidney 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) maintains normal in vivo specificity for mineralocorticoid receptor (MR) by converting the active steroid corticosterone to inactive 11-dehydrocorticosterone, leaving aldosterone to occupy the MR. Clinical observations support the hypothesis that 11 beta-HSD also protects the distal colonic MR from glucocorticoid excess.	Corticosterone	175-189	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	138-140
8374149-2	1993	Defensins were shown to have corticostatic activity in vivo in the models of stress- and ACTG-induced elevation of corticosterone.	Corticosterone	115-129	actin gamma 1	Homo sapiens	89-93
8393384-4	1993	Subcutaneous infusion for one week with alpha-helical-CRH or corticotropin-inhibiting peptide (1 nmol.min-1), which are competitive inhibitors of CRH and ACTH, evoked a further significant lowering of plasma corticosterone concentration and markedly enhanced adrenal atrophy in hypophysectomized rats.	Corticosterone	208-222	corticotropin releasing hormone	Rattus norvegicus	54-57
8252605-7	1993	GR affinity for corticosterone is higher perinatally than at later ages.	Corticosterone	16-30	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-2
8347826-0	1993	Corticosterone increases FGF-2 (bFGF) immunoreactivity in the substantia nigra of the rat.	Corticosterone	0-14	fibroblast growth factor 2	Rattus norvegicus	25-30
8332263-10	1993	The appearance of Fos-like immunoreactivity within caudal portions of the nucleus was increased only by noxious intensities of stimulation and was further enhanced in animals with low levels of corticosterone.	Corticosterone	194-208	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	18-21
8347826-0	1993	Corticosterone increases FGF-2 (bFGF) immunoreactivity in the substantia nigra of the rat.	Corticosterone	0-14	fibroblast growth factor 2	Rattus norvegicus	32-36
8347826-1	1993	The effects of acute and subchronic (7 days) administrations of the adrenocortical hormone corticosterone on basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity were studied in the substantia nigra of the rat by semiquantitative immunocytochemistry coupled with image analysis.	Corticosterone	91-105	fibroblast growth factor 2	Rattus norvegicus	109-139
8347826-1	1993	The effects of acute and subchronic (7 days) administrations of the adrenocortical hormone corticosterone on basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity were studied in the substantia nigra of the rat by semiquantitative immunocytochemistry coupled with image analysis.	Corticosterone	91-105	fibroblast growth factor 2	Rattus norvegicus	141-145
8347826-1	1993	The effects of acute and subchronic (7 days) administrations of the adrenocortical hormone corticosterone on basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity were studied in the substantia nigra of the rat by semiquantitative immunocytochemistry coupled with image analysis.	Corticosterone	91-105	fibroblast growth factor 2	Rattus norvegicus	147-152
8347826-2	1993	Corticosterone was able to increase FGF-2 immunoreactivity in different nigral subregions and cell types (astrocytes and neurones) depending on the duration of the treatment.	Corticosterone	0-14	fibroblast growth factor 2	Rattus norvegicus	36-41
8391371-2	1993	Both peripheral and central injections of these three NK-2 receptor agonists stimulated adrenal corticosterone release in gonad-intact and castrated male rats.	Corticosterone	96-110	tachykinin receptor 2	Rattus norvegicus	54-67
8498539-6	1993	The apparent Km for corticosterone was 16.3 x 10(-8) M, a value comparable to that observed for enzyme from CCD, and a Vmax of 4.8 x 10(-12) mol.mg protein-1.min-1.	Corticosterone	20-34	CD59 molecule (CD59 blood group)	Homo sapiens	158-163
8509133-7	1993	Non-cytokine mediators present during stimulation, such as noradrenaline, dexamethasone and corticosterone, are also potent inhibitors of IFN-gamma-induced activation of microglia and macrophages.	Corticosterone	92-106	interferon gamma	Rattus norvegicus	138-147
8510182-4	1993	The corticosterone administration gradually shifted the GR immunoreactivity (IR) from the cytoplasm to the nucleus.	Corticosterone	4-18	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	56-58
8100073-2	1993	The role of different neurotransmitters in mediation of the cocaine-induced elevation of plasma corticosterone (CORT) were investigated in rats by using transmitter antagonists.	Corticosterone	96-110	cortistatin	Rattus norvegicus	112-116
8482733-2	1993	Although these peptides are best known for their broad spectrum antimicrobial properties, they also inhibit ACTH (corticotropin) stimulated corticosterone production, chemoattract monocytes, and lyse mammalian cells.	Corticosterone	140-154	proopiomelanocortin	Homo sapiens	108-112
8507349-4	1993	The increase of rat hippocampal NGF mRNA and protein content was associated with an increase in plasma corticosterone content.	Corticosterone	103-117	nerve growth factor	Rattus norvegicus	32-35
8495362-5	1993	Preincubation of the cells with the synthetic glucocorticoid, dexamethasone (2 x 10(-5)-2 x 10(-8) M), as well as with the natural hormone, corticosterone, markedly inhibited the secretion of both TNF alpha and PGE2.	Corticosterone	140-154	tumor necrosis factor	Homo sapiens	197-206
8495490-9	1993	Mice implanted with corticosterone pellets experienced severe losses of CD4+/CD8+ cells, resulting in thymocyte subpopulation and CD3 profiles more similar to those of hydrocortisone-injected mice than those of PD mice.	Corticosterone	20-34	CD4 antigen	Mus musculus	72-75
8495490-9	1993	Mice implanted with corticosterone pellets experienced severe losses of CD4+/CD8+ cells, resulting in thymocyte subpopulation and CD3 profiles more similar to those of hydrocortisone-injected mice than those of PD mice.	Corticosterone	20-34	CD3 antigen, epsilon polypeptide	Mus musculus	130-133
8384136-0	1993	Corticosterone effect on insulin receptor number and kinase activity in chicken muscle and liver.	Corticosterone	0-14	insulin receptor	Gallus gallus	25-41
8511199-1	1993	Radioimmunoassay (RIA) of plasma aldosterone (ALDO) can be hampered by cross-reactivity with plasma corticosterone (CORT).	Corticosterone	100-114	cortistatin	Rattus norvegicus	116-120
8462455-2	1993	Northern blot analyses showed a rapid increase of IL6 transcripts in spleen, pituitary gland, and adrenals that was paralleled by pronounced elevations in serum IL6 and corticosterone levels.	Corticosterone	169-183	interleukin 6	Rattus norvegicus	50-53
8462455-4	1993	Corticosterone pretreatment (10 mg/kg) completely blocked the increase of IL6 in serum and IL6 mRNA in spleen, adrenals, and hypophysis.	Corticosterone	0-14	interleukin 6	Rattus norvegicus	74-77
8462455-4	1993	Corticosterone pretreatment (10 mg/kg) completely blocked the increase of IL6 in serum and IL6 mRNA in spleen, adrenals, and hypophysis.	Corticosterone	0-14	interleukin 6	Rattus norvegicus	91-94
8388707-1	1993	A 7-day subcutaneous infusion with the AVP antagonist [Deamino-Pen1, Val4, D-Arg8]-vasopressin (AVP-A; 3 nmol.kg-1 x min-1) significantly lowered plasma aldosterone concentration in rats, without affecting the plasma levels of ACTH and corticosterone.	Corticosterone	236-250	arginine vasopressin	Rattus norvegicus	39-42
8388707-1	1993	A 7-day subcutaneous infusion with the AVP antagonist [Deamino-Pen1, Val4, D-Arg8]-vasopressin (AVP-A; 3 nmol.kg-1 x min-1) significantly lowered plasma aldosterone concentration in rats, without affecting the plasma levels of ACTH and corticosterone.	Corticosterone	236-250	arginine vasopressin	Rattus norvegicus	96-99
8319828-5	1993	The 11 beta-HSD1A enzyme converted corticosterone and cortisol to their respective 11-dehydro metabolites with an absolute dependence on NADP as co-factor, while the 26 kDa 11 beta-HSD1B protein was unable to metabolize either steroid.	Corticosterone	35-49	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	4-11
8319828-5	1993	The 11 beta-HSD1A enzyme converted corticosterone and cortisol to their respective 11-dehydro metabolites with an absolute dependence on NADP as co-factor, while the 26 kDa 11 beta-HSD1B protein was unable to metabolize either steroid.	Corticosterone	35-49	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	173-180
8487952-10	1993	Corticotropin releasing factor also caused a marked rise in plasma corticosterone.	Corticosterone	67-81	corticotropin releasing hormone	Rattus norvegicus	0-30
8510764-7	1993	Mineralocorticoids (corticosterone and deoxycorticosterone acetate) inhibited 3H-adrenaline uptake (when COMT was inhibited) and 3H-metanephrine formation (when COMT was functional) as effectively as did sexual steroids (17-beta-oestradiol, progesterone and testosterone); hydrocortisone (hemisuccinate or phosphate) had no effect (for concentrations up to 120 mumol/l).	Corticosterone	20-34	catechol O-methyltransferase	Oryctolagus cuniculus	105-109
8510764-7	1993	Mineralocorticoids (corticosterone and deoxycorticosterone acetate) inhibited 3H-adrenaline uptake (when COMT was inhibited) and 3H-metanephrine formation (when COMT was functional) as effectively as did sexual steroids (17-beta-oestradiol, progesterone and testosterone); hydrocortisone (hemisuccinate or phosphate) had no effect (for concentrations up to 120 mumol/l).	Corticosterone	20-34	catechol O-methyltransferase	Oryctolagus cuniculus	161-165
8385781-8	1993	The decrease in the apparent number of anterior pituitary corticotropin-releasing factor receptors following 3 days of stress may be due, in part, to increased plasma corticosterone levels and/or increased corticotropin-releasing factor secretion during that time.	Corticosterone	167-181	corticotropin releasing hormone	Rattus norvegicus	58-88
8440178-9	1993	TGF beta 1 significantly inhibited deoxycorticosterone- and corticosterone-stimulated aldosterone production by over 50%.	Corticosterone	40-54	transforming growth factor beta 1	Bos taurus	0-10
8441016-4	1993	Administration of exogenous corticosterone (CORT) at the time of ADX maintained the level of 5-HT1A receptor mRNA expression within the range of SHAM animals.	Corticosterone	28-42	cortistatin	Homo sapiens	44-48
8441016-4	1993	Administration of exogenous corticosterone (CORT) at the time of ADX maintained the level of 5-HT1A receptor mRNA expression within the range of SHAM animals.	Corticosterone	28-42	5-hydroxytryptamine receptor 1A	Homo sapiens	93-108
8450471-4	1993	Similarly, 8-OH-DPAT was more efficacious than BMY 7378 in eliciting corticosterone secretion, a response mediated by postsynaptic 5-HT1A receptors, whereas BMY 7378 was as efficacious as 8-OH-DPAT in inhibiting striatal accumulation of 5-hydroxytryptophan, a response mediated by presynaptic 5-HT1A receptors.	Corticosterone	69-83	5-hydroxytryptamine receptor 1A	Rattus norvegicus	131-137
8387190-2	1993	Plasma corticosterone (CORT) levels were recorded via radioimmunoassay (RIA) on day 4 to measure adrenal response to these treatments.	Corticosterone	7-21	cortistatin	Rattus norvegicus	23-27
8043803-2	1993	In mice recombinant human IL-1 beta dose-dependently induces high level serum corticosterone.	Corticosterone	78-92	interleukin 1 beta	Homo sapiens	26-35
8384136-2	1993	The hypoglycemic effect of exogenous insulin was completely abolished within 2 weeks of treatment, suggesting a corticosterone-induced insulin resistance.	Corticosterone	112-126	insulin	Gallus gallus	37-44
8384136-2	1993	The hypoglycemic effect of exogenous insulin was completely abolished within 2 weeks of treatment, suggesting a corticosterone-induced insulin resistance.	Corticosterone	112-126	insulin	Gallus gallus	135-142
8384136-4	1993	After 1 or 2 weeks, corticosterone treatment significantly reduced liver insulin receptor kinase activity toward the artificial substrate poly(Glu4,Tyr1).	Corticosterone	20-34	insulin receptor	Gallus gallus	73-89
8384136-6	1993	Therefore the corticosterone-induced insulin resistance is accounted for, at least in part, by altered hepatic receptor numbers and kinase activity.	Corticosterone	14-28	insulin	Gallus gallus	37-44
8485540-7	1993	We used removal of glucocorticoids by adrenalectomy or metyrapone blockade of corticosterone synthesis, to stimulate endogenous secretion of CRH and vasopressin.	Corticosterone	78-92	corticotropin releasing hormone	Rattus norvegicus	141-144
8485540-7	1993	We used removal of glucocorticoids by adrenalectomy or metyrapone blockade of corticosterone synthesis, to stimulate endogenous secretion of CRH and vasopressin.	Corticosterone	78-92	arginine vasopressin	Rattus norvegicus	149-160
8474317-5	1993	Plasma corticosterone levels were markedly elevated following rIL-1 alpha injection, with a maximal level occurring at 30 minutes.	Corticosterone	7-21	interleukin 1 alpha	Rattus norvegicus	62-73
8018447-8	1993	Levels of corticosterone and fibrinogen were increased by injection of IL-1, and decreased by the IL-1 Inhibitor.	Corticosterone	10-24	interleukin 1 alpha	Homo sapiens	71-75
8861286-0	1996	Decrease of endogenous vasopressin release necessary for expression of the circadian rise in plasma corticosterone: a reverse microdialysis study.	Corticosterone	100-114	arginine vasopressin	Homo sapiens	23-34
8861286-3	1996	In the present study we employed microdialysis-mediated intracerebral administration of vasopressin (VP) and its V(1) -antagonist to study the mechanisms underlying the circadian control of the release of the adrenal hormone corticosterone.	Corticosterone	225-239	arginine vasopressin	Homo sapiens	88-99
8861286-5	1996	A similar administration of VP at the end of the light period completely prevented the diurnal rise in plasma corticosterone.	Corticosterone	110-124	arginine vasopressin	Homo sapiens	28-30
8861286-7	1996	Thus, the daily decline in VP release sets a specific time window for the occurrence of the daily corticosterone peak.	Corticosterone	98-112	arginine vasopressin	Homo sapiens	27-29
8861286-8	1996	On the other hand, during the dark period corticosterone levels are decreasing together with basal VP levels.	Corticosterone	42-56	arginine vasopressin	Homo sapiens	99-101
8018447-8	1993	Levels of corticosterone and fibrinogen were increased by injection of IL-1, and decreased by the IL-1 Inhibitor.	Corticosterone	10-24	interleukin 1 receptor antagonist	Homo sapiens	98-112
8384045-6	1993	In addition, serum corticosterone and ACTH were significantly elevated in IL-1 beta-treated animals 4 h postinjection.	Corticosterone	19-33	interleukin 1 beta	Rattus norvegicus	74-83
8221155-10	1993	Additionally, plasma corticosterone, but not epinephrine and norepinephrine, concentrations were elevated in response to AVP and OXT infusions.	Corticosterone	21-35	arginine vasopressin	Rattus norvegicus	121-124
8221155-10	1993	Additionally, plasma corticosterone, but not epinephrine and norepinephrine, concentrations were elevated in response to AVP and OXT infusions.	Corticosterone	21-35	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	129-132
8491087-4	1993	Acute peripheral injection of IL-1 alpha or beta causes dose-dependent increases in plasma adrenocorticotropic hormone (ACTH) and corticosterone secretion.	Corticosterone	130-144	interleukin 1 alpha	Rattus norvegicus	30-40
8380375-7	1993	In contrast to the ACTH responses, basal and CRH-stimulated plasma corticosterone levels were significantly elevated (P &lt; 0.001), and the responses to acute stress were normal.	Corticosterone	67-81	corticotropin releasing hormone	Rattus norvegicus	45-48
8307110-5	1993	Food intake and weight gain were also elevated (vs. groups A and C) as were the basal plasma corticosterone levels (vs. group C) in insulin treated rats.	Corticosterone	93-107	insulin	Homo sapiens	132-139
8219776-5	1993	Recombinant IL-1 also induced a drastic increase in plasma corticosterone levels in various strains of normal mice.	Corticosterone	59-73	interleukin 1 complex	Mus musculus	12-16
8219776-7	1993	However, in young lupus-prone (NZB/W)F1 and MRL/MP-lpr mice, a significantly lower increase in plasma corticosterone levels was observed after injection of recombinant IL-1, suggesting a deficient immuno-endocrine communication via the HPA loop in this instance as well.	Corticosterone	102-116	interleukin 1 complex	Mus musculus	168-172
8219776-8	1993	Detailed studies to identify further cytokines with GIF activity in the avian and murine systems showed that both IL-6 and tumor necrosis factor-alpha could induce increased plasma corticosterone levels in mice, but not in chickens.	Corticosterone	181-195	interleukin 6	Mus musculus	114-150
22290998-8	1993	Completeness of hypophysectomy was assessed by measuring plasma corticosterone (CORT) level changes 20 min after i.c.v.	Corticosterone	64-78	cortistatin	Rattus norvegicus	80-84
8385256-2	1993	Pretreatment with specific antibodies (raised against CRH, AVP and ACTH resp.) revealed that Hypnorm administration activated the ACTH-corticosterone system in the 10-day old rat and its effect is mediated by CRH and/or AVP.	Corticosterone	135-149	corticotropin releasing hormone	Rattus norvegicus	54-57
8385256-2	1993	Pretreatment with specific antibodies (raised against CRH, AVP and ACTH resp.) revealed that Hypnorm administration activated the ACTH-corticosterone system in the 10-day old rat and its effect is mediated by CRH and/or AVP.	Corticosterone	135-149	corticotropin releasing hormone	Rattus norvegicus	209-212
8391619-1	1993	Corticotropin-Releasing-Hormone (CRH) is the principal secretagogue for plasma ACTH and corticosterone secretion and plays an important role in coordinating a variety of physiological and behavioral responses to stress.	Corticosterone	88-102	corticotropin releasing hormone	Rattus norvegicus	0-31
8391619-1	1993	Corticotropin-Releasing-Hormone (CRH) is the principal secretagogue for plasma ACTH and corticosterone secretion and plays an important role in coordinating a variety of physiological and behavioral responses to stress.	Corticosterone	88-102	corticotropin releasing hormone	Rattus norvegicus	33-36
8412501-0	1993	Pancreatic polypeptide stimulates corticosterone secretion by isolated rat adrenocortical cells.	Corticosterone	34-48	pancreatic polypeptide	Rattus norvegicus	0-22
8412501-1	1993	Pancreatic polypeptide (PP) dose-dependently enhanced both basal and submaximally ACTH-stimulated corticosterone production by dispersed zona fasciculata/reticularis cells of the rat adrenal gland.	Corticosterone	98-112	pancreatic polypeptide	Rattus norvegicus	0-27
8412510-5	1993	In addition, simultaneous administration of alpha-MSH deleted the stimulatory effects of CRF on serum corticosterone levels.	Corticosterone	102-116	proopiomelanocortin	Rattus norvegicus	44-53
18475500-5	1993	Serum corticosterone levels were measured only at 4 h. Significant increases in IL-1beta levels precede cell influx suggesting IL-1beta plays a role in the maintenance of cell accumulation in the pleural cavity.	Corticosterone	6-20	interleukin 1 beta	Rattus norvegicus	80-88
18475500-5	1993	Serum corticosterone levels were measured only at 4 h. Significant increases in IL-1beta levels precede cell influx suggesting IL-1beta plays a role in the maintenance of cell accumulation in the pleural cavity.	Corticosterone	6-20	interleukin 1 beta	Rattus norvegicus	127-135
8164615-4	1993	In this study, we examined the functional effects of three of the metabolites of corticosterone on membrane transport in toad and turtle bladders; we also analyzed the oxidoreductase pathways for corticosterone metabolism.	Corticosterone	196-210	thioredoxin reductase 1	Homo sapiens	168-182
8164615-7	1993	Analysis of the oxidoreductase pathways in this tissue revealed that most of the corticosterone was oxidized to 11-dehydrocorticosterone, a biologically active compound; 11-dehydrocorticosterone was further metabolized to 11-dehydro-20-dihydrocorticosterone, a biologically inactive compound.	Corticosterone	81-95	thioredoxin reductase 1	Homo sapiens	16-30
8381527-1	1993	Neuromedin-N (NMN) (6 micrograms/100 g body weight for 2 d) partially reversed the dexamethasone (Dx)-induced inhibition of ACTH release and the consequent adrenal atrophy and decrease in glucocorticoid (corticosterone) plasma concentration in rats.	Corticosterone	204-218	neurotensin	Rattus norvegicus	0-12
8381527-1	1993	Neuromedin-N (NMN) (6 micrograms/100 g body weight for 2 d) partially reversed the dexamethasone (Dx)-induced inhibition of ACTH release and the consequent adrenal atrophy and decrease in glucocorticoid (corticosterone) plasma concentration in rats.	Corticosterone	204-218	neurotensin	Rattus norvegicus	14-17
8479618-5	1993	A 24-hour pretreatment with corticosterone (CORT), the principal GC in the rat, enhanced both hypoxic and hypoglycemic cell damage, as measured by lactate dehydrogenase assay.	Corticosterone	28-42	cortistatin	Rattus norvegicus	44-48
8510802-2	1993	When mice are treated for 1 week with exogenous corticosterone (CORT) they become insensitive to the behavioral and physiological actions of nicotine and also have a reduction in brain alpha-bungarotoxin (BTX) receptor binding.	Corticosterone	48-62	cortistatin	Mus musculus	64-68
8510803-2	1993	Numerous studies have shown that administration of 5-HT1A receptor agonists increases plasma corticosterone (CS) concentrations in rats; however, the mechanism has not been established.	Corticosterone	93-107	5-hydroxytryptamine receptor 1A	Rattus norvegicus	51-57
8510803-2	1993	Numerous studies have shown that administration of 5-HT1A receptor agonists increases plasma corticosterone (CS) concentrations in rats; however, the mechanism has not been established.	Corticosterone	109-111	5-hydroxytryptamine receptor 1A	Rattus norvegicus	51-57
8510803-5	1993	Under pentobarbital anesthesia, central administration of the selective 5-HT1A agonists, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and ipsapirone decreased plasma CS levels, relative to saline-treated control rats, at all doses tested (0.001-20 nmol).	Corticosterone	172-174	5-hydroxytryptamine receptor 1A	Rattus norvegicus	72-78
7870994-2	1993	Other investigators have suggested that tolerance to multiple nicotine injections in mice may be due, in part, to elevated plasma corticosterone (CORT) levels, since repeated nicotine injections are associated with elevated CORT, chronically elevated CORT reduces nicotine responsiveness and adrenalectomy disrupts nicotine tolerance.	Corticosterone	130-144	cortistatin	Mus musculus	146-150
7870994-2	1993	Other investigators have suggested that tolerance to multiple nicotine injections in mice may be due, in part, to elevated plasma corticosterone (CORT) levels, since repeated nicotine injections are associated with elevated CORT, chronically elevated CORT reduces nicotine responsiveness and adrenalectomy disrupts nicotine tolerance.	Corticosterone	130-144	cortistatin	Mus musculus	224-228
7870994-2	1993	Other investigators have suggested that tolerance to multiple nicotine injections in mice may be due, in part, to elevated plasma corticosterone (CORT) levels, since repeated nicotine injections are associated with elevated CORT, chronically elevated CORT reduces nicotine responsiveness and adrenalectomy disrupts nicotine tolerance.	Corticosterone	130-144	cortistatin	Mus musculus	224-228
8390701-0	1993	Interleukin-1 beta stimulates adrenocorticotropin and corticosterone release in 10-day-old rat pups.	Corticosterone	54-68	interleukin 1 beta	Rattus norvegicus	0-18
1476186-2	1992	11 beta-HSD inactivates cortisol and corticosterone, allowing the more abundantly produced glucocorticoids access to the mineralocorticoid receptor (MR) in the kidney, where they act as mineralocorticoids.	Corticosterone	37-51	nuclear receptor subfamily 3 group C member 2	Homo sapiens	121-147
1476186-2	1992	11 beta-HSD inactivates cortisol and corticosterone, allowing the more abundantly produced glucocorticoids access to the mineralocorticoid receptor (MR) in the kidney, where they act as mineralocorticoids.	Corticosterone	37-51	nuclear receptor subfamily 3 group C member 2	Homo sapiens	149-151
1482145-3	1992	IL-1 induced a dose-dependent increase in corticosterone levels in plasma.	Corticosterone	42-56	interleukin 1 complex	Mus musculus	0-4
1482145-4	1992	Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice.	Corticosterone	10-24	interleukin 1 alpha	Homo sapiens	62-66
1482145-4	1992	Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice.	Corticosterone	10-24	proopiomelanocortin	Homo sapiens	127-159
1482145-4	1992	Next, the corticosterone peak induced by a protective dose of IL-1 (800 ng) was simulated by administration of synthetic human adrenocorticotropic hormone 1-24 (ACTH) in normal and neutropenic mice.	Corticosterone	10-24	proopiomelanocortin	Homo sapiens	161-165
1482145-5	1992	Although corticosterone levels induced by pretreatment with IL-1 or ACTH were virtually identical, the ACTH-induced corticosterone peak was not associated with protection against Klebsiella pneumoniae infection in normal mice and Pseudomonas aeruginosa infection in neutropenic mice.	Corticosterone	9-23	interleukin 1 complex	Mus musculus	60-64
1482145-5	1992	Although corticosterone levels induced by pretreatment with IL-1 or ACTH were virtually identical, the ACTH-induced corticosterone peak was not associated with protection against Klebsiella pneumoniae infection in normal mice and Pseudomonas aeruginosa infection in neutropenic mice.	Corticosterone	116-130	proopiomelanocortin	Homo sapiens	103-107
1482145-7	1992	In addition, we found that plasma corticosterone concentrations during K. pneumoniae infection were significantly lower after pretreatment with IL-1 than after pretreatment with ACTH or vehicle, probably reflecting the better physical condition of IL-1-treated mice.	Corticosterone	34-48	interleukin 1 complex	Mus musculus	144-148
1482145-7	1992	In addition, we found that plasma corticosterone concentrations during K. pneumoniae infection were significantly lower after pretreatment with IL-1 than after pretreatment with ACTH or vehicle, probably reflecting the better physical condition of IL-1-treated mice.	Corticosterone	34-48	proopiomelanocortin	Homo sapiens	178-182
1482145-7	1992	In addition, we found that plasma corticosterone concentrations during K. pneumoniae infection were significantly lower after pretreatment with IL-1 than after pretreatment with ACTH or vehicle, probably reflecting the better physical condition of IL-1-treated mice.	Corticosterone	34-48	interleukin 1 complex	Mus musculus	248-252
1473014-4	1992	Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS.	Corticosterone	107-121	interleukin 1 receptor antagonist	Mus musculus	18-22
1473014-4	1992	Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS.	Corticosterone	107-121	interleukin 1 alpha	Mus musculus	56-66
1473014-4	1992	Administration of IRAP largely prevented the effects of IL-1 alpha or IL-1 beta on the elevation of plasma corticosterone and the concomitant increase in hypothalamic norepinephrine metabolism, but failed to alter the responses to LPS.	Corticosterone	107-121	interleukin 1 beta	Mus musculus	70-79
1337504-13	1992	In ectopic ACTH syndrome the characteristic mineralocorticoid excess can be accounted for by a combination of increased secretion of cortisol, corticosterone and of 11-deoxycorticosterone and decreased inactivation of cortisol and corticosterone by 11 beta-dehydrogenase.	Corticosterone	143-157	proopiomelanocortin	Homo sapiens	11-15
1337504-13	1992	In ectopic ACTH syndrome the characteristic mineralocorticoid excess can be accounted for by a combination of increased secretion of cortisol, corticosterone and of 11-deoxycorticosterone and decreased inactivation of cortisol and corticosterone by 11 beta-dehydrogenase.	Corticosterone	173-187	proopiomelanocortin	Homo sapiens	11-15
1295567-5	1992	CS enhanced the proportion of Mac1+, Ia+ and FcR+ cells and maintained high levels of IL2 receptor (IL2R) positive immature cells.	Corticosterone	0-2	integrin subunit alpha M	Homo sapiens	30-34
1295567-5	1992	CS enhanced the proportion of Mac1+, Ia+ and FcR+ cells and maintained high levels of IL2 receptor (IL2R) positive immature cells.	Corticosterone	0-2	interleukin 2 receptor subunit beta	Homo sapiens	86-98
1295567-5	1992	CS enhanced the proportion of Mac1+, Ia+ and FcR+ cells and maintained high levels of IL2 receptor (IL2R) positive immature cells.	Corticosterone	0-2	interleukin 2 receptor subunit beta	Homo sapiens	100-104
1295567-6	1992	Functional cytotoxic cells were detected in CS-treated organ cultures which expressed a Thy 1-, CD8- phenotype, atypical for thymus derived killer cells.	Corticosterone	44-46	Thy-1 cell surface antigen	Homo sapiens	88-93
1295567-6	1992	Functional cytotoxic cells were detected in CS-treated organ cultures which expressed a Thy 1-, CD8- phenotype, atypical for thymus derived killer cells.	Corticosterone	44-46	CD8a molecule	Homo sapiens	96-99
1335726-3	1992	In control ADX animals, we observed the negative feedback effects of exogenous corticosterone on plasma ACTH and anterior pituitary POMC mRNA.	Corticosterone	79-93	proopiomelanocortin	Rattus norvegicus	132-136
1335726-6	1992	In control ADX animals, corticosterone replacement resulted in increased anterior pituitary GH mRNA and reduced prolactin mRNA.	Corticosterone	24-38	prolactin	Rattus norvegicus	112-121
1336558-11	1992	Corticosterone rapidly decreased NGF mRNA but not the BDNF mRNAs, and had no effect on seizure-induced NGF or BDNF mRNAs.	Corticosterone	0-14	nerve growth factor	Mus musculus	33-36
1369598-0	1992	Quantitative autoradiographic analyses of the time course and reversibility of corticosterone-induced decreases in binding at 5-HT1A receptors in rat forebrain.	Corticosterone	79-93	5-hydroxytryptamine receptor 1A	Rattus norvegicus	126-132
1369598-1	1992	Quantitative autoradiography was used to evaluate the time course and reversibility of corticosterone (CORT)-induced decreases in binding at 5-HT1A receptors in the dorsal hippocampus, cortex and septum of the male rat.	Corticosterone	87-101	cortistatin	Rattus norvegicus	103-107
1369598-1	1992	Quantitative autoradiography was used to evaluate the time course and reversibility of corticosterone (CORT)-induced decreases in binding at 5-HT1A receptors in the dorsal hippocampus, cortex and septum of the male rat.	Corticosterone	87-101	5-hydroxytryptamine receptor 1A	Rattus norvegicus	141-147
1488127-12	1992	There was a marked correlation between the number of c-fos-positive neurons in the supraoptic nucleus or paraventricular nucleus and plasma levels of corticosterone 60 min after infusion, but not with arginine-vasopressin levels.	Corticosterone	150-164	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-58
1478689-5	1992	Pituitary proopiomelanocortin (POMC) mRNA content progressively decreased with a nadir between Days 6 and 8, accompanied by a loss of the adrenocortical ornithine decarboxylase (ODC) circadian rhythm of activity and a transient reduction of plasma corticosterone (CS) levels (Days 3-6, obvious during the dark phase).	Corticosterone	248-262	proopiomelanocortin	Rattus norvegicus	10-29
1478689-5	1992	Pituitary proopiomelanocortin (POMC) mRNA content progressively decreased with a nadir between Days 6 and 8, accompanied by a loss of the adrenocortical ornithine decarboxylase (ODC) circadian rhythm of activity and a transient reduction of plasma corticosterone (CS) levels (Days 3-6, obvious during the dark phase).	Corticosterone	264-266	proopiomelanocortin	Rattus norvegicus	10-29
1490727-6	1992	In the absence of a direct and lasting effect on TNF-producing cells, the host reaction responsible for the inhibitory effect of IL-1 could be related to the overproduction of corticosterone that occurred after IL-1 injection, since it was not observed in adrenalectomized animals.	Corticosterone	176-190	interleukin 1 complex	Mus musculus	129-133
1490727-6	1992	In the absence of a direct and lasting effect on TNF-producing cells, the host reaction responsible for the inhibitory effect of IL-1 could be related to the overproduction of corticosterone that occurred after IL-1 injection, since it was not observed in adrenalectomized animals.	Corticosterone	176-190	interleukin 1 complex	Mus musculus	211-215
1465198-13	1992	Corticosterone levels were raised by both stress and corticotropin-releasing factor, but pretreatment with alpha-helical corticotropin-releasing factor reduced them after either procedure, which correlates with c-fos expression in the paraventricular nucleus and ventrolateral septum.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	53-83
1465198-13	1992	Corticosterone levels were raised by both stress and corticotropin-releasing factor, but pretreatment with alpha-helical corticotropin-releasing factor reduced them after either procedure, which correlates with c-fos expression in the paraventricular nucleus and ventrolateral septum.	Corticosterone	0-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	211-216
1416111-2	1992	Following stimulation of the animals with corticotropin releasing hormone (CRH), the corticosterone serum levels reached a maximum 1 hour after stimulation with CRH.	Corticosterone	85-99	corticotropin releasing hormone	Rattus norvegicus	42-73
1416111-2	1992	Following stimulation of the animals with corticotropin releasing hormone (CRH), the corticosterone serum levels reached a maximum 1 hour after stimulation with CRH.	Corticosterone	85-99	corticotropin releasing hormone	Rattus norvegicus	75-78
1416111-2	1992	Following stimulation of the animals with corticotropin releasing hormone (CRH), the corticosterone serum levels reached a maximum 1 hour after stimulation with CRH.	Corticosterone	85-99	corticotropin releasing hormone	Rattus norvegicus	161-164
1331681-0	1992	Modulation of gamma-actin and alpha 1-tubulin expression by corticosterone during neuronal plasticity in the hippocampus.	Corticosterone	60-74	actin, gamma 1	Rattus norvegicus	14-25
1331681-4	1992	Corticosterone administration, which is known to impair the reinnervation process in ECL rats, prevents the lesion-induced reduction in gamma-actin expression and blocks the induction of alpha 1-tubulin in the deafferented hippocampus.	Corticosterone	0-14	actin, gamma 1	Rattus norvegicus	136-147
1308199-0	1992	Phenytoin prevents stress- and corticosterone-induced atrophy of CA3 pyramidal neurons.	Corticosterone	31-45	carbonic anhydrase 3	Rattus norvegicus	65-68
1308199-1	1992	Repeated daily restraint stress and daily corticosterone administration to adult male Sprague-Dawley rats leads to decreases in the number of branch points and length of dendrites of CA3 pyramidal neurons of the hippocampal formation.	Corticosterone	42-56	carbonic anhydrase 3	Rattus norvegicus	183-186
1308199-4	1992	Stress- and corticosterone-induced effects on dendritic length and branch point number are more pronounced on the apical, as opposed to the basal, CA3 dendrites that receive the largest mossy fiber input from the dentate gyrus.	Corticosterone	12-26	carbonic anhydrase 3	Rattus norvegicus	147-150
1308199-5	1992	Because phenytoin is also known to prevent ischemic damage, these results are consistent with a model in which stress- and corticosterone-induced CA3 dendritic atrophy is produced by excitatory amino acids released from the mossy fibers.	Corticosterone	123-137	carbonic anhydrase 3	Rattus norvegicus	146-149
1418384-3	1992	In an attempt to elucidate the mechanisms controlling this phenomenon, we used Northern analysis to investigate the effect of corticosterone and thyroid hormones (tri-iodothyronine and tetra-iodothyronine) on hepatic IGF-II mRNA levels.	Corticosterone	126-140	insulin-like growth factor 2	Rattus norvegicus	217-223
1418384-4	1992	The administration of either corticosterone or tri-iodothyronine to 8-day-old pups resulted in a significant decrease in IGF-II mRNA when the animals were examined on day 12 of life.	Corticosterone	29-43	insulin-like growth factor 2	Rattus norvegicus	121-127
21554647-7	1992	The areas under the curve for the plasma ACTH and corticosterone levels following an injection of 10mug/kg ovine CRH in conscious rats, were of similar magnitude in control and 60 h cold exposed rats.	Corticosterone	50-64	corticotropin releasing hormone	Rattus norvegicus	113-116
1335552-6	1992	In addition, LEW/N corticotrophs were more sensitive to dexamethasone and to corticosterone suppression of CRH-stimulated ACTH secretion compared to F344/N.	Corticosterone	77-91	corticotropin releasing hormone	Homo sapiens	107-110
1335552-6	1992	In addition, LEW/N corticotrophs were more sensitive to dexamethasone and to corticosterone suppression of CRH-stimulated ACTH secretion compared to F344/N.	Corticosterone	77-91	proopiomelanocortin	Homo sapiens	122-126
1475015-6	1992	Further experiments were conducted to study the relative potency of prolactin to antagonize the in vitro corticosterone-induced suppression of ConA-stimulated lymphocytes.	Corticosterone	105-119	prolactin	Rattus norvegicus	68-77
1475015-8	1992	They also showed that when prolactin and corticosterone are simultaneously added to the cultures, the immunostimulatory effect induced by a dose of 10(-8) M of prolactin can either predominate over a weak suppressive action of corticosterone (2 x 10(-8) M) or totally antagonize to normal values a marked immunosuppression induced by a higher dose of corticosterone (10(-7) M).	Corticosterone	41-55	prolactin	Rattus norvegicus	160-169
1475015-8	1992	They also showed that when prolactin and corticosterone are simultaneously added to the cultures, the immunostimulatory effect induced by a dose of 10(-8) M of prolactin can either predominate over a weak suppressive action of corticosterone (2 x 10(-8) M) or totally antagonize to normal values a marked immunosuppression induced by a higher dose of corticosterone (10(-7) M).	Corticosterone	227-241	prolactin	Rattus norvegicus	27-36
1475015-8	1992	They also showed that when prolactin and corticosterone are simultaneously added to the cultures, the immunostimulatory effect induced by a dose of 10(-8) M of prolactin can either predominate over a weak suppressive action of corticosterone (2 x 10(-8) M) or totally antagonize to normal values a marked immunosuppression induced by a higher dose of corticosterone (10(-7) M).	Corticosterone	227-241	prolactin	Rattus norvegicus	160-169
1475015-8	1992	They also showed that when prolactin and corticosterone are simultaneously added to the cultures, the immunostimulatory effect induced by a dose of 10(-8) M of prolactin can either predominate over a weak suppressive action of corticosterone (2 x 10(-8) M) or totally antagonize to normal values a marked immunosuppression induced by a higher dose of corticosterone (10(-7) M).	Corticosterone	227-241	prolactin	Rattus norvegicus	27-36
1475015-8	1992	They also showed that when prolactin and corticosterone are simultaneously added to the cultures, the immunostimulatory effect induced by a dose of 10(-8) M of prolactin can either predominate over a weak suppressive action of corticosterone (2 x 10(-8) M) or totally antagonize to normal values a marked immunosuppression induced by a higher dose of corticosterone (10(-7) M).	Corticosterone	227-241	prolactin	Rattus norvegicus	160-169
1329524-4	1992	Incubation of quartered adrenals with adrenocorticotropic hormone (ACTH, 10(-12) to 10(-8) M) or IL-1 beta (10(-12) to 10(-8) M) resulted in dose-dependent increases (P less than 0.05) in corticosterone release.	Corticosterone	188-202	interleukin 1 beta	Rattus norvegicus	97-106
1329524-5	1992	Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period.	Corticosterone	0-14	interleukin 1 beta	Rattus norvegicus	64-73
1329524-5	1992	Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period.	Corticosterone	0-14	interleukin 1 alpha	Rattus norvegicus	169-179
1329524-5	1992	Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period.	Corticosterone	0-14	interleukin 1 beta	Rattus norvegicus	184-193
1329524-5	1992	Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period.	Corticosterone	203-217	interleukin 1 beta	Rattus norvegicus	64-73
1329524-5	1992	Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period.	Corticosterone	203-217	interleukin 1 alpha	Rattus norvegicus	169-179
1329524-5	1992	Corticosterone release stimulated by 10(-8) M doses of ACTH and IL-1 beta began to rise 30 min after incubation and peaked at 2 h. In primary cultures of adrenal cells, IL-1 alpha and IL-1 beta elevated corticosterone release after a 24-h incubation period.	Corticosterone	203-217	interleukin 1 beta	Rattus norvegicus	184-193
1393608-2	1992	The present studies were conducted to offer a comparison of the effects of orally administered corticosterone (CORT) with ICV glucocorticoids [CORT, CORT acetate, or dexamethasone (DEX)].	Corticosterone	95-109	cortistatin	Rattus norvegicus	111-115
1505471-10	1992	In adx males, nuclear Type II-ir was restored in CA1 and the dentate gyrus after treatment with corticosterone or progesterone.	Corticosterone	96-110	carbonic anhydrase 1	Rattus norvegicus	49-52
1398554-8	1992	Both corticosterone and dexamethasone inhibited hCG-stimulated T production in a dose-dependent manner.	Corticosterone	5-19	hypertrichosis 2 (generalised, congenital)	Homo sapiens	48-51
1398556-5	1992	Corticosterone replacement restored the CRH-induced behavioral response to preoperative levels, whereas the CRH-induced tachycardia was partially restored.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	40-43
1398556-7	1992	It is concluded that circulating adrenal corticosterone in ADX rats is involved in the expression of the behavioral and cardiac effect of central CRH.	Corticosterone	41-55	corticotropin releasing hormone	Rattus norvegicus	146-149
1330207-0	1992	The cocaine-induced elevation of plasma corticosterone is mediated by endogenous corticotropin-releasing factor (CRF) in rats.	Corticosterone	40-54	corticotropin releasing hormone	Rattus norvegicus	81-111
1330207-1	1992	The role of endogenous corticotropin-releasing factor (CRF) in the cocaine-induced corticosterone response was investigated by using the immunoneutralization and receptor blockade of endogenous CRF.	Corticosterone	83-97	corticotropin releasing hormone	Rattus norvegicus	23-53
1354202-0	1992	P-glycoprotein transports corticosterone and is photoaffinity-labeled by the steroid.	Corticosterone	26-40	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
1354202-4	1992	Furthermore, corticosterone is effluxed from multi-drug-resistant cells by P-glycoprotein.	Corticosterone	13-27	ATP binding cassette subfamily B member 1	Homo sapiens	75-89
1354202-5	1992	These data suggest that corticosterone may be an endogenous substrate for P-glycoprotein.	Corticosterone	24-38	ATP binding cassette subfamily B member 1	Homo sapiens	74-88
1356586-2	1992	We have examined whether corticosterone (CORT), the principal glucocorticoid in the rat, could exacerbate hypoxic energy failure in cultured hippocampal astrocytes.	Corticosterone	25-39	cortistatin	Rattus norvegicus	41-45
21554633-4	1992	Pre-training CEA lesions, but not post-training intervention, abolished the conditioned elevations of circulating plasma corticosterone and prolactin.	Corticosterone	121-135	carcinoembryonic antigen gene family 4	Rattus norvegicus	13-16
1448177-0	1992	Long lasting attenuation of 8-OH-DPAT-induced corticosterone secretion after a single injection of a 5-HT1A receptor agonist.	Corticosterone	46-60	5-hydroxytryptamine receptor 1A	Rattus norvegicus	101-107
1448177-2	1992	The 5-HT1A receptors mediating the corticosterone secretion appear to be postsynaptic to the 5-HT neurons, since the response to 8-OH-DPAT was not decreased but potentiated by depletion of 5-HT with p-chlorophenylalanine pretreatment of the animals.	Corticosterone	35-49	5-hydroxytryptamine receptor 1A	Rattus norvegicus	4-10
1448177-6	1992	The subsensitivity development was specific for the 5-HT1A receptor-mediated corticosterone secretion, since the increase in serum corticosterone produced by stimulation of other receptor systems, e.g. alpha 2-adrenoreceptors (clonidine) or 5-HT2 receptors [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI)] was not affected.	Corticosterone	77-91	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-58
1448177-6	1992	The subsensitivity development was specific for the 5-HT1A receptor-mediated corticosterone secretion, since the increase in serum corticosterone produced by stimulation of other receptor systems, e.g. alpha 2-adrenoreceptors (clonidine) or 5-HT2 receptors [1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, (DOI)] was not affected.	Corticosterone	131-145	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-58
1334002-5	1992	More recent studies have shown that chronic stimulation with corticotropin-releasing hormone (CRH) produces some of the same changes; however, the magnitude differs because of corticosterone feedback.	Corticosterone	176-190	corticotropin releasing hormone	Homo sapiens	61-92
1334002-5	1992	More recent studies have shown that chronic stimulation with corticotropin-releasing hormone (CRH) produces some of the same changes; however, the magnitude differs because of corticosterone feedback.	Corticosterone	176-190	corticotropin releasing hormone	Homo sapiens	94-97
1334002-13	1992	Inhibition of ACTH secretion by ion channel blockers or corticosterone has potent inhibitory effects on percentages of CRH-bound cells.	Corticosterone	56-70	proopiomelanocortin	Homo sapiens	14-18
1334002-13	1992	Inhibition of ACTH secretion by ion channel blockers or corticosterone has potent inhibitory effects on percentages of CRH-bound cells.	Corticosterone	56-70	corticotropin releasing hormone	Homo sapiens	119-122
1446915-9	1992	PRL in chickens also modifies the level and the diurnal rhythm of corticosterone which, in turn, influences the immunoregulatory effect exerted by PRL.	Corticosterone	66-80	prolactin	Gallus gallus	0-3
1446915-9	1992	PRL in chickens also modifies the level and the diurnal rhythm of corticosterone which, in turn, influences the immunoregulatory effect exerted by PRL.	Corticosterone	66-80	prolactin	Gallus gallus	147-150
1612727-0	1992	In vivo inhibition of lipopolysaccharide-induced lethality and tumor necrosis factor synthesis by Rhodobacter sphaeroides diphosphoryl lipid A is dependent on corticosterone induction.	Corticosterone	159-173	tumor necrosis factor	Cavia porcellus	63-84
1613495-3	1992	Using fetal rat hippocampal cultures, we asked whether hypoxic and hypoglycemic cell damage in vitro could be exacerbated by direct exposure to corticosterone (CORT).	Corticosterone	144-158	cortistatin	Rattus norvegicus	160-164
1641068-5	1992	This lesion reduced the CS response to human IL-1 alpha by 82-86%, but did not alter that to 20 min restraint, although there was a nonsignificant decrease in the CS response following 3 min of restraint.	Corticosterone	24-26	interleukin 1 alpha	Homo sapiens	45-55
1504843-0	1992	The magnocellular arginine-vasopressin mRNA responds differently to food deprivation between the supraoptic and paraventricular nuclei of the hypothalamus in adrenalectomized rats with low corticosterone replacement.	Corticosterone	189-203	arginine vasopressin	Rattus norvegicus	18-38
1626640-0	1992	Corticosterone induces rat liver alcohol dehydrogenase mRNA but not enzyme protein or activity.	Corticosterone	0-14	aldo-keto reductase family 1 member A1	Rattus norvegicus	33-54
1626640-10	1992	The rate of transcription of the ADH gene in nuclei isolated at the end of 10 days of treatment from corticosterone-treated adrenalectomized rats was not statistically different from that in the oil-treated adrenalectomized ones.	Corticosterone	101-115	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	33-36
1626640-11	1992	The disparity between ADH activity and protein levels and the mRNA level may have resulted from other effects of corticosterone, e.g., stimulation of protein degradation or effects on translation.	Corticosterone	113-127	alcohol dehydrogenase 1C (class I), gamma polypeptide	Rattus norvegicus	22-25
8425481-1	1993	The mineralocorticoid receptor displays equal affinity for aldosterone and corticosterone.	Corticosterone	75-89	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	4-30
7683503-6	1993	Serum corticosterone levels increased by 3 h after injection in all three models, and equivalent raised serum levels of acute phase proteins were detected within 12-24 h. The expression of IL-6 receptor mRNA in hepatocytes increased markedly as early as 3 h after treatment and message levels began to decline by 6-12 h in all three models.	Corticosterone	6-20	interleukin 6 receptor	Rattus norvegicus	189-202
1586154-0	1992	Regulation of the malic enzyme and fatty acid synthase genes in chick embryo hepatocytes in culture: corticosterone and carnitine regulate responsiveness to triiodothyronine.	Corticosterone	101-115	fatty acid synthase	Gallus gallus	35-54
1502913-0	1992	Pavlovian conditioning of corticotropin-releasing factor-induced increase of blood pressure and corticosterone secretion in the rat.	Corticosterone	96-110	corticotropin releasing hormone	Rattus norvegicus	26-56
1504369-4	1992	In intact mice the serum corticosterone level fell 1 h after lipid A injection to below detectable levels, which was followed by a brisk increase reaching the peak level of 48-50 micrograms/100 ml at 2 h. Both TNF production and the lethal effect of PLS/LA could be inhibited in ADX mice by glucocorticoid treatment.	Corticosterone	25-39	tumor necrosis factor	Mus musculus	210-213
1319453-7	1992	IL-6 had no effect on message levels but did increase circulating ACTH and corticosterone levels both 4 h and 24 h after injection.	Corticosterone	75-89	interleukin 6	Homo sapiens	0-4
1616878-1	1992	The effect of corticosterone injection and of acute and repeated stress on rat liver cytosol glucocorticoid receptor was studied to ascertain whether corticosterone-induced glucocorticoid receptor (GR) regulation also takes place in intact animals as it does in adrenalectomized ones.	Corticosterone	150-164	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	173-196
1616878-1	1992	The effect of corticosterone injection and of acute and repeated stress on rat liver cytosol glucocorticoid receptor was studied to ascertain whether corticosterone-induced glucocorticoid receptor (GR) regulation also takes place in intact animals as it does in adrenalectomized ones.	Corticosterone	150-164	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	198-200
1616878-5	1992	On the other hand, sustained hypersecretion of corticosterone evoked by repeated stress significantly reduced the number of GR in rat liver cytosol without any change in Kd.	Corticosterone	47-61	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	124-126
1616878-7	1992	Further, repeated stress causes down-regulation of GR in the liver, most probably by sustained corticosterone secretion, yet the effect of other stress factors cannot be excluded.	Corticosterone	95-109	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	51-53
1353629-7	1992	Rats receiving an inescapable footshock 1 day earlier showed a further elevated corticosterone response to the 5-HT1A receptor agonist ipsapirone even before exposing them to the conditioned stress situation.	Corticosterone	80-94	5-hydroxytryptamine receptor 1A	Rattus norvegicus	111-117
1504818-0	1992	Vasopressin-containing neurons of the suprachiasmatic nuclei inhibit corticosterone release.	Corticosterone	69-83	arginine vasopressin	Homo sapiens	0-11
1504818-3	1992	The present results show that when infused in the paraventricular/dorsomedial nucleus of the hypothalamus femtomolar concentrations of vasopressin (VP), but not vasoactive intestinal peptide (VIP), are able to suppress elevated levels of corticosterone in SCN-lesioned animals to basal daytime values.	Corticosterone	238-252	arginine vasopressin	Homo sapiens	135-146
1504818-4	1992	On the other hand, infusion of the VP antagonist in the same hypothalamic area induced a sevenfold increase of basal corticosterone levels in intact animals.	Corticosterone	117-131	arginine vasopressin	Homo sapiens	35-37
1504818-6	1992	These results imply that the SCN can influence the daily corticosterone rhythm through its VP-containing projection to the paraventricular/dorsomedial nucleus of the hypothalamus.	Corticosterone	57-71	arginine vasopressin	Homo sapiens	91-93
1349027-8	1992	Corticosterone, which induces lipomodulin, a PLA2 inhibitor protein inactivated by PKA, equally abolished the pump effects of DA, fenoldopam, forskolin, and dBcAMP, suggesting that lipomodulin might act between PKA and PLA2 in cAMP-dependent pump regulation.	Corticosterone	0-14	phospholipase A2 group IB	Rattus norvegicus	45-49
1324039-0	1992	Influence of maternal ingestion of Aroclor 1254 (PCB) or FireMaster BP-6 (PBB) on unstimulated and stimulated corticosterone levels in young rats.	Corticosterone	110-124	pyruvate carboxylase	Rattus norvegicus	49-52
1324039-0	1992	Influence of maternal ingestion of Aroclor 1254 (PCB) or FireMaster BP-6 (PBB) on unstimulated and stimulated corticosterone levels in young rats.	Corticosterone	110-124	Blood pressure QTL 6	Rattus norvegicus	68-72
1349027-8	1992	Corticosterone, which induces lipomodulin, a PLA2 inhibitor protein inactivated by PKA, equally abolished the pump effects of DA, fenoldopam, forskolin, and dBcAMP, suggesting that lipomodulin might act between PKA and PLA2 in cAMP-dependent pump regulation.	Corticosterone	0-14	phospholipase A2 group IB	Rattus norvegicus	219-223
1613427-2	1992	VIP caused a significant increase in perfusion medium flow rate and in aldosterone and corticosterone secretion by the isolated perfused rat adrenal gland, with a threshold of 1 pmol in 200 microliters, but did not affect basal steroid secretion by collagenase-dispersed adrenocortical cells at any concentration used, from 10 pmol/l to 10 mumol/l.	Corticosterone	87-101	vasoactive intestinal peptide	Rattus norvegicus	0-3
1324761-0	1992	Corticosterone implants in the paraventricular nucleus inhibit ACTH and corticosterone responses and the release of corticotropin-releasing factor following neural stimuli.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	116-146
1325954-8	1992	Injection of MENK decreased corticosterone levels and increased ACTH levels in the plasma of sham-adrenalectomized mice.	Corticosterone	28-42	pro-opiomelanocortin-alpha	Mus musculus	13-17
1325229-2	1992	After 3 and 5 days of IL-1 beta infusion, the level of circulating ACTH was below the control level, while the plasma concentration of corticosterone was strikingly elevated.	Corticosterone	135-149	interleukin 1 beta	Rattus norvegicus	22-31
1511271-4	1992	Both unconditioned and conditioned stressors increased c-fos mRNA levels in the locus ceruleus which correlated with stress-induced plasma corticosterone concentrations.	Corticosterone	139-153	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-60
1533016-0	1992	Autoradiographic analyses of the effects of adrenalectomy and corticosterone on 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat.	Corticosterone	62-76	5-hydroxytryptamine receptor 1A	Rattus norvegicus	80-97
1533016-1	1992	Quantitative autoradiography was used to evaluate the effects of adrenalectomy (ADX) and corticosterone (CORT) on binding at 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat.	Corticosterone	89-103	cortistatin	Rattus norvegicus	105-109
1533016-1	1992	Quantitative autoradiography was used to evaluate the effects of adrenalectomy (ADX) and corticosterone (CORT) on binding at 5-HT1A and 5-HT1B receptors in the dorsal hippocampus and cortex of the rat.	Corticosterone	89-103	5-hydroxytryptamine receptor 1A	Rattus norvegicus	125-142
1564428-3	1992	In lean rats the enhanced corticosterone secretion was associated with non-significant increments in the expression of preproCRF mRNA in the PVN and of POMC mRNA in the pituitary gland, while mifepristone significantly (P less than 0.05) reduced the expression of preproCRF mRNA in the PVN of obese Zucker rats.	Corticosterone	26-40	proopiomelanocortin	Rattus norvegicus	152-156
1501757-1	1992	The electrophysiological effects of various concentrations of corticosterone (CORT) on the hippocampus were investigated using extracellular recordings from CA1 hippocampal slice preparations subjected to four different extracellular concentrations of calcium.	Corticosterone	62-76	cortistatin	Homo sapiens	78-82
1311232-13	1992	Thus, the adrenal may be an important convergence point between the immune and endocrine systems, and because IL-6 release is regulated by IL-1 alpha, IL-1 beta, ACTH, and angiotensin II, and this cytokine stimulates corticosterone release, IL-6 may play an important paracrine role in integrating the signals derived from these systems.	Corticosterone	217-231	interleukin 6	Rattus norvegicus	110-114
1323803-4	1992	If a low concentration of the mixed agonist corticosterone (0.5 nM, close to the Kd for the MR) was continuously perfused in vitro, 5HT responses were steadily depressed with a delay of 2 h, while high levels of corticosterone (5 nM, around Kd for GR) only temporarily reduced 5HT responses.	Corticosterone	44-58	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	92-94
1614286-6	1992	However, the cyclo-oxygenase inhibitor, diclofenac, did attenuate the IL-1-induced elevation of plasma corticosterone and the neurochemical changes.	Corticosterone	103-117	interleukin 1 complex	Mus musculus	70-74
1596738-9	1992	This comparison suggests that the IL-1 beta stimulation of serum corticosterone and IL-6 and inhibition of food and water intake are events more centrally mediated than the IL-1 beta-induced hypoglycemia.	Corticosterone	65-79	interleukin 1 beta	Mus musculus	34-43
1310283-0	1992	Indirect evidence to suggest that prolactin mediates the adrenal action of haloperidol to stimulate aldosterone and corticosterone secretion in rats.	Corticosterone	116-130	prolactin	Rattus norvegicus	34-43
1346492-1	1992	The gene for steroid 18-hydroxylase (P-450C18) has been recently assigned to encode corticosterone methyl oxidases Type I and Type II which were previously postulated to catalyze the final two steps in the biosynthesis of aldosterone in humans.	Corticosterone	84-98	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	37-45
1551226-4	1992	We found that SCW-induced plasma corticosterone (CORT) responses do not significantly increase during development in LEW/N, while such responses clearly appear at postnatal day 14 in F344/N and outbred Harlan-Sprague-Dawley (HSD) rats.	Corticosterone	33-47	cortistatin	Rattus norvegicus	49-53
1309707-2	1992	beta-EP potentiated the effects of ACTH and alpha-MSH on the zona fasciculata corticosterone production but inhibited those on the zona glomerulosa aldosterone production.	Corticosterone	78-92	proopiomelanocortin	Rattus norvegicus	44-53
1330003-0	1992	Effect of rat atrial natriuretic factor on in vivo and in vitro aldosterone and corticosterone secretions in the rat during the perinatal period.	Corticosterone	80-94	natriuretic peptide A	Rattus norvegicus	14-39
1330003-1	1992	The effect of rat atrial natriuretic factor (rANF) on aldosterone and corticosterone secretion was investigated in vivo in 21-day-old rat fetuses injected intravenously through the umbilical vein and in vitro on isolated adrenal cells from 17-, 19- and 21-day-old fetuses and 1-, 2-, 3- and 4-week-old rats.	Corticosterone	70-84	natriuretic peptide A	Rattus norvegicus	45-49
1330003-2	1992	In vivo, rANF (50 pmol/50 microliters/fetus) inhibited both basal levels and secretion of aldosterone stimulated by adrenocorticotropin hormone (ACTH(1-24), 0.25 pmol/50 microliters/fetus), but not corticosterone secretion.	Corticosterone	198-212	natriuretic peptide A	Rattus norvegicus	9-13
1330003-8	1992	In isolated adrenal cells from 2-week-old rats, rANF (10 nmol/l) inhibited the secretion of aldosterone induced by ACTH(1-24) (0.1 nmol/l), and by different steroids of the aldosterone synthetic pathway (progesterone, 11-deoxycorticosterone, corticosterone, 1 mumol/l for each steroid).	Corticosterone	226-240	natriuretic peptide A	Rattus norvegicus	48-52
1466767-3	1992	Others have reported that the levels of CaBP are regulated by corticosterone but our results (in adrenalectomized Wistar or hypophysectomized Sprague-Dawley rats) suggest that any effect is small and transitory.	Corticosterone	62-76	S100 calcium binding protein G	Rattus norvegicus	40-44
8104764-0	1993	Somatostatin inhibits cell proliferation and corticosterone secretion in the early stage of adrenal regeneration.	Corticosterone	45-59	somatostatin	Rattus norvegicus	0-12
8104764-2	1993	It was found that somatostatin (25 micrograms/kg) inhibited both cell proliferation and corticosterone output on the fourth and on the eighth days of adrenal regeneration.	Corticosterone	88-102	somatostatin	Rattus norvegicus	18-30
1309333-0	1992	Physiological role of corticotropin-releasing factor in the control of adrenocorticotropin-mediated corticosterone release from the rat adrenal gland.	Corticosterone	100-114	corticotropin releasing hormone	Rattus norvegicus	22-52
1435084-1	1992	The effects of 5 day corticosterone treatment (50 mg/kg s.c.; 2 x daily) are investigated on the behavioural and neuroendocrine responses to a 5-HT-1A selective agonist, 8-hydroxy -2-(di-n-propylamino) tetralin (8-OH-DPAT) in rats.	Corticosterone	21-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	143-150
1598065-0	1992	Alteration in the levels of 1,25-(OH)2D3 and corticosterone found in experimental diabetes reduces nerve growth factor (NGF) gene expression in vitro.	Corticosterone	45-59	nerve growth factor	Rattus norvegicus	99-118
1598065-0	1992	Alteration in the levels of 1,25-(OH)2D3 and corticosterone found in experimental diabetes reduces nerve growth factor (NGF) gene expression in vitro.	Corticosterone	45-59	nerve growth factor	Rattus norvegicus	120-123
1598065-2	1992	Using the cell line L929 cultured in a steroid-free medium, we show that the alteration in the levels of corticosterone and 1,25-(OH)2D3 found in vivo in experimental diabetes is able to decrease the synthesis of NGF by these cells.	Corticosterone	105-119	nerve growth factor	Rattus norvegicus	213-216
1319007-9	1992	An abrupt decrease of 30% in the CRH mRNA content was detected in the hypothalamus within 2 h after dark (8 PM) and coincided with the peak of plasma corticosterone levels.	Corticosterone	150-164	corticotropin releasing hormone	Homo sapiens	33-36
1319007-12	1992	We conclude that CRH mRNA levels fluctuate diurnally but are inversely related to corticosterone levels only in the early evening.	Corticosterone	82-96	corticotropin releasing hormone	Homo sapiens	17-20
1614286-10	1992	Forty min following IP IL-1, the corticosterone response to IL-1 was markedly attenuated.	Corticosterone	33-47	interleukin 1 complex	Mus musculus	23-27
1614286-10	1992	Forty min following IP IL-1, the corticosterone response to IL-1 was markedly attenuated.	Corticosterone	33-47	interleukin 1 complex	Mus musculus	60-64
1620654-1	1992	Cholecystokinin octapeptide (CCK-8) and ceruletide (1 microgram/kg) produced a pronounced increment of plasma corticosterone levels at 30 min after intraperitoneal administration.	Corticosterone	110-124	cholecystokinin	Rattus norvegicus	0-15
19912833-4	1991	Pretreatment with a single dose of corticosterone before surgery in the morning produced high corticosterone levels similar to those in the evening and prevented the decrease of ENK mRNA in the hippocampus.	Corticosterone	35-49	proenkephalin	Rattus norvegicus	178-181
1480351-3	1992	Furthermore, basal and stress-induced concentrations of corticosterone (CORT), ACTH and hypothalamic secretagogues remain at very low levels.	Corticosterone	56-70	cortistatin	Homo sapiens	72-76
1365851-1	1992	Oral pretreatment with aldosterone or corticosterone blocked the memory-enhancing effects of the calcium antagonist nimodipine, the ACE inhibitor captopril, the NMDA blocker CGP 37,849, and the glycine antagonist strychnine in a passive-avoidance test in mice.	Corticosterone	38-52	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	132-135
1664369-3	1991	Intravenous bolus injection of 1000pmol/kg of ET3 in free moving rats caused significant increases in plasma ACTH and corticosterone levels, almost equivalent to those of 100pmol/kg of rat corticotropin-releasing hormone (rCRH).	Corticosterone	118-132	endothelin 3	Rattus norvegicus	46-49
1664369-10	1991	The results indicate that ET3 may play the role of a neuropeptide and that the stimulation of the CRH-neurons is mainly responsible for activation of ACTH and corticosterone release.	Corticosterone	159-173	corticotropin releasing hormone	Rattus norvegicus	98-101
1773913-3	1991	Pups were maternally deprived for varying lengths of time (i.e., 0, 2, 4, 8, &amp; 24 hr); at the end of this period, corticosterone (CORT) secretion in response to stress (novelty or novelty plus saline injection) and ACTH injection was measured.	Corticosterone	118-132	cortistatin	Rattus norvegicus	134-138
1664448-6	1991	Intravenous infusion of 0.8 ml sheep anti-ANP serum but not control (non-immune) sheep serum, through an indwelling intra-atrial cannula in conscious male rats resulted in a marked and significant increase in plasma ACTH and corticosterone concentrations.	Corticosterone	225-239	natriuretic peptide A	Rattus norvegicus	42-45
1664070-5	1991	Similarly, in adrenal cortex, the content of DBI and MBR increased during the first hour, following acute stress and this increase paralleled the increase in plasma corticosterone.	Corticosterone	165-179	diazepam binding inhibitor	Rattus norvegicus	45-48
1655393-1	1991	This study describes the regulation of adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4-isomerase (3 beta HSD) expression and activity by ACTH and corticosterone, alone or in combination, in intact male and female rats as well as the effect of ACTH on 3 beta HSD expression and activity in the adrenals of hypophysectomized female animals.	Corticosterone	165-179	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	117-127
1777041-2	1991	The aim of the present study was to analyse the effect of chronic stress on expression of the POMC gene in the medial basal hypothalamus and pituitary, and on serum concentrations of LH, beta-endorphin and corticosterone.	Corticosterone	206-220	proopiomelanocortin	Rattus norvegicus	94-98
1659997-1	1991	In rat hippocampus, the mineralocorticoid receptor and the glucocorticoid receptor bind corticosterone with high affinity.	Corticosterone	88-102	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	24-50
1659997-1	1991	In rat hippocampus, the mineralocorticoid receptor and the glucocorticoid receptor bind corticosterone with high affinity.	Corticosterone	88-102	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	59-82
1658300-9	1991	However, pretreatment with the 5-HT2/5-HT1C antagonist ritanserin virtually eliminated the cocaine-induced elevation of corticosterone.	Corticosterone	120-134	5-hydroxytryptamine receptor 2C	Rattus norvegicus	37-43
1958512-1	1991	11 beta-Hydroxysteroid dehydrogenase (11 beta-OHSD) metabolizes corticosterone (B) to inactive 11-dehydrocorticosterone and thus protects the non-specific renal mineralocorticoid receptor from exposure to B in vivo.	Corticosterone	64-78	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	161-187
1917978-3	1991	The dissociation rate constants of BB CBG for cortisol (4.42 nM) and corticosterone (1.43 nM) are both about 50% higher than those associated with Wistar CBG, but no obvious difference in the steroid binding specificity of BB and Wistar CBGs was detected.	Corticosterone	69-83	serpin family A member 6	Rattus norvegicus	38-41
1734933-1	1992	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) dictates specificity for the mineralocorticoid receptor (MR) by converting the active steroid cortisol to cortisone in man (corticosterone to 11-dehydrocorticosterone in rodents), leaving aldosterone to occupy the MR.	Corticosterone	175-189	nuclear receptor subfamily 3 group C member 2	Homo sapiens	80-106
1734933-1	1992	11 beta-Hydroxysteroid dehydrogenase (11 beta-HSD) dictates specificity for the mineralocorticoid receptor (MR) by converting the active steroid cortisol to cortisone in man (corticosterone to 11-dehydrocorticosterone in rodents), leaving aldosterone to occupy the MR.	Corticosterone	175-189	nuclear receptor subfamily 3 group C member 2	Homo sapiens	108-110
1657667-8	1991	NPY injected into the paraventricular nucleus and other regions causes hyperphagia, obesity, and increased secretion of insulin, glucagon, ACTH, and corticosterone.	Corticosterone	149-163	neuropeptide Y	Rattus norvegicus	0-3
1657575-0	1991	The "mineralocorticoid-like" actions conferred on corticosterone by carbenoxolone are inhibited by the mineralocorticoid receptor (type I) antagonist RU28318.	Corticosterone	50-64	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	103-129
1655978-2	1991	In previous studies we found that NGF production is up-regulated by 12-O-tetradecanoylphorbol 13-acetate (TPA) and serum, down-regulated by corticosterone, and unaffected by dibutyryl-cyclic AMP (db-cyclic AMP) in fibroblasts.	Corticosterone	140-154	nerve growth factor	Homo sapiens	34-37
1655978-5	1991	Corticosterone reduced NGF mRNA and NGF production to less than 10% of basal levels whether or not TPA or serum, or both, were present but not in the presence of the glucocorticoid antagonist RU486.	Corticosterone	0-14	nerve growth factor	Homo sapiens	23-26
1655978-5	1991	Corticosterone reduced NGF mRNA and NGF production to less than 10% of basal levels whether or not TPA or serum, or both, were present but not in the presence of the glucocorticoid antagonist RU486.	Corticosterone	0-14	nerve growth factor	Homo sapiens	36-39
1655978-9	1991	Forskolin enhanced the induction of both junB and c-fos mRNA whereas corticosterone prolonged junB mRNA induction.	Corticosterone	69-83	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-98
1655978-10	1991	Thus, TPA induction of NGF mRNA is modulated differentially by corticosterone and cyclic AMP.	Corticosterone	63-77	nerve growth factor	Homo sapiens	23-26
1913664-6	1991	Dexamethasone inhibited and ketoconazole, an inhibitor of corticosterone biosynthesis, enhanced IL-1 alpha-mediated chemosensitization in these models.	Corticosterone	58-72	interleukin 1 alpha	Homo sapiens	96-106
1752731-1	1991	The effects of adrenalectomy with or without replacement doses of corticosterone were examined on the levels of messenger RNA for malic enzyme (ME) and glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in adipose tissue and liver from Zucker fatty (fa/fa) and littermate lean rats.	Corticosterone	66-80	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	194-199
1761279-3	1991	It was the purpose of this study to evaluate basal and corticotropin releasing hormone (CRH)-stimulated CS secretion in ovariectomized (OVX) control (C) and streptozotocin-induced diabetic (D) rats given blank, 5 mcg and 20 mcg estradiol (E2) implants to determine if adrenal CS secretion in the diabetic is normalized by E2 treatment.	Corticosterone	104-106	corticotropin releasing hormone	Rattus norvegicus	55-86
1761279-3	1991	It was the purpose of this study to evaluate basal and corticotropin releasing hormone (CRH)-stimulated CS secretion in ovariectomized (OVX) control (C) and streptozotocin-induced diabetic (D) rats given blank, 5 mcg and 20 mcg estradiol (E2) implants to determine if adrenal CS secretion in the diabetic is normalized by E2 treatment.	Corticosterone	104-106	corticotropin releasing hormone	Rattus norvegicus	88-91
1761279-9	1991	The CS response to CRH stimulation was not different between OVX female diabetic and control rats.	Corticosterone	4-6	corticotropin releasing hormone	Rattus norvegicus	19-22
1761279-10	1991	Estrogen enhanced the CS response to CRH stimulation in control animals but not in diabetic animals suggesting altered estrogen action at the pituitary level in diabetic animals.	Corticosterone	22-24	corticotropin releasing hormone	Rattus norvegicus	37-40
1655393-1	1991	This study describes the regulation of adrenal 3 beta-hydroxy-5-ene-steroid dehydrogenase/delta 5-delta 4-isomerase (3 beta HSD) expression and activity by ACTH and corticosterone, alone or in combination, in intact male and female rats as well as the effect of ACTH on 3 beta HSD expression and activity in the adrenals of hypophysectomized female animals.	Corticosterone	165-179	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	270-280
1655393-6	1991	On the other hand, corticosterone treatment results in a marked inhibition of 3 beta HSD mRNA levels, enzymatic activity, and protein content in intact animals; this effect is probably mediated by a decrease in ACTH secretion.	Corticosterone	19-33	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	78-88
1655393-7	1991	The present data show that ACTH and corticosterone, via its inhibitory action on ACTH secretion, have potent and opposite effects on the expression of two 3 beta HSD genes in the rat adrenal; a parallel effect is observed on both type I and II 3 beta HSD.	Corticosterone	36-50	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	155-165
1655393-7	1991	The present data show that ACTH and corticosterone, via its inhibitory action on ACTH secretion, have potent and opposite effects on the expression of two 3 beta HSD genes in the rat adrenal; a parallel effect is observed on both type I and II 3 beta HSD.	Corticosterone	36-50	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	244-254
1837482-5	1991	IL-1ra at 20 micrograms/mouse completely blocked induction of IL-6 and markedly inhibited hypoglycemia and increase in serum corticosterone induced by 0.1 micrograms of IL-1.	Corticosterone	125-139	interleukin 1 receptor antagonist	Mus musculus	0-6
1775135-9	1991	Expression of these cDNAs in cultured COS-1 cells demonstrated that the CYP11B1 product could only 11 beta-hydroxylate 11-deoxycortisol or deoxycorticosterone, whereas the CYP11B2 product could also 18-hydroxylate cortisol or corticosterone.	Corticosterone	144-158	cytochrome P450 family 11 subfamily B member 1	Homo sapiens	72-79
1660971-1	1991	Corticosterone can affect electrical properties of CA1 pyramidal neurons via binding to two corticoid receptor types, the mineralocorticoid (MR) and glucocorticoid receptor (GR).	Corticosterone	0-14	carbonic anhydrase 1	Homo sapiens	51-54
1660971-1	1991	Corticosterone can affect electrical properties of CA1 pyramidal neurons via binding to two corticoid receptor types, the mineralocorticoid (MR) and glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	149-172
1660971-1	1991	Corticosterone can affect electrical properties of CA1 pyramidal neurons via binding to two corticoid receptor types, the mineralocorticoid (MR) and glucocorticoid receptor (GR).	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	174-176
1665293-0	1991	Role of corticosterone in modulation of eicosanoid biosynthesis and antiinflammatory activity by 5-lipoxygenase (5-LO) and cyclooxygenase (CO) inhibitors.	Corticosterone	8-22	arachidonate 5-lipoxygenase	Mus musculus	97-111
1665293-1	1991	The effectiveness of 5-lipoxygenase (LO) and dual LO/cyclooxygenase (CO) inhibitors when administered by the topical or oral routes was significantly decreased in corticosterone depleted (adrenalectomized, Adx) mice as compared to sham mice in the mouse arachidonic acid (AA) induced ear edema model.	Corticosterone	163-177	arachidonate 5-lipoxygenase	Mus musculus	21-35
1959027-4	1991	Finally, NPY has a remarkably potent stimulatory effect on feeding behavior, which is characterized by a selective increase in carbohydrate ingestion that is strongest at the beginning of the active feeding cycle and is dependent upon circulating levels of corticosterone.	Corticosterone	257-271	neuropeptide Y	Homo sapiens	9-12
1716205-10	1991	While LPS-treated adrex mice had no significant increases in serum corticosterone, corticosterone levels in LPS-treated galactosamine-sensitized mice were comparable to LPS-stimulated normals suggesting that LPS tolerance involves both glucocorticoid-dependent and -independent components.	Corticosterone	83-97	toll-like receptor 4	Mus musculus	108-111
1716205-10	1991	While LPS-treated adrex mice had no significant increases in serum corticosterone, corticosterone levels in LPS-treated galactosamine-sensitized mice were comparable to LPS-stimulated normals suggesting that LPS tolerance involves both glucocorticoid-dependent and -independent components.	Corticosterone	83-97	toll-like receptor 4	Mus musculus	108-111
1716205-10	1991	While LPS-treated adrex mice had no significant increases in serum corticosterone, corticosterone levels in LPS-treated galactosamine-sensitized mice were comparable to LPS-stimulated normals suggesting that LPS tolerance involves both glucocorticoid-dependent and -independent components.	Corticosterone	83-97	toll-like receptor 4	Mus musculus	108-111
1653277-3	1991	5 h after endotoxin treatment, the PEPCK transcription rate and the amount of mRNA(PEPCK) were significantly decreased at a time when the insulin/glucagon (I/G) molar ratio and plasma corticosterone levels were significantly increased.	Corticosterone	184-198	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	35-40
1677678-1	1991	Short (5 days)- to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats.	Corticosterone	40-54	glial fibrillary acidic protein	Rattus norvegicus	147-178
1677678-1	1991	Short (5 days)- to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats.	Corticosterone	40-54	glial fibrillary acidic protein	Rattus norvegicus	180-184
1677678-1	1991	Short (5 days)- to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats.	Corticosterone	56-60	glial fibrillary acidic protein	Rattus norvegicus	147-178
1677678-1	1991	Short (5 days)- to long-term (4 months) corticosterone (CORT) administration by injection, pellet implantation, or in the drinking water decreased glial fibrillary acidic protein (GFAP) by 20-40% in hippocampus and cortex of intact rats.	Corticosterone	56-60	glial fibrillary acidic protein	Rattus norvegicus	180-184
1911420-2	1991	Corticosterone was derivatized at 3 different positions and coupled covalently to bovine serum albumin (BSA).	Corticosterone	0-14	albumin	Rattus norvegicus	89-102
1649559-4	1991	The effect of dexmedetomidine, 10(-8)-10(-3) M, on adrenocorticotrophic hormone (ACTH) stimulated release of corticosterone was assessed in isolated rat adrenal cells.	Corticosterone	109-123	proopiomelanocortin	Canis lupus familiaris	81-85
1649559-9	1991	At dexmedetomidine concentrations greater than 10(-7) M, a dose-dependent inhibition of corticosterone release was detected in response to ACTH stimulation in vitro.	Corticosterone	88-102	proopiomelanocortin	Canis lupus familiaris	139-143
1855993-2	1991	The peak in serum TNF was detected prior to maximal elevation in endogenous corticosterone and was no longer apparent 3 to 4 h post-LPS injection, a point at which corticosterone and IL-1 levels had significantly increased.	Corticosterone	76-90	tumor necrosis factor	Mus musculus	18-21
1855993-2	1991	The peak in serum TNF was detected prior to maximal elevation in endogenous corticosterone and was no longer apparent 3 to 4 h post-LPS injection, a point at which corticosterone and IL-1 levels had significantly increased.	Corticosterone	164-178	tumor necrosis factor	Mus musculus	18-21
1869915-1	1991	Pyramidal neurons in the rat CA1 hippocampal area contain intracellular mineralocorticoid receptors (MRs) and glucocorticoid receptors (GRs) to which the adrenal hormone corticosterone can bind with differential affinity.	Corticosterone	170-184	carbonic anhydrase 1	Rattus norvegicus	29-32
1888673-8	1991	However, the simultaneous downregulation of both hippocampal and lymphocyte glucocorticoid receptors by corticosterone provides support for the hypothesis that circulating lymphocytes do reflect some aspects of brain glucocorticoid receptor regulation.	Corticosterone	104-118	nuclear receptor subfamily 3 group C member 1	Homo sapiens	76-99
1766548-3	1991	The present paper reports on the effects of long-term adrenalectomy (ADX) and subsequent replacement with supraphysiological doses of corticosterone (compound B, CB) upon the in vitro basal and CRH- and AVP-stimulated release of beta-END from the rat hypothalamus.	Corticosterone	134-148	corticotropin releasing hormone	Rattus norvegicus	194-197
1766548-3	1991	The present paper reports on the effects of long-term adrenalectomy (ADX) and subsequent replacement with supraphysiological doses of corticosterone (compound B, CB) upon the in vitro basal and CRH- and AVP-stimulated release of beta-END from the rat hypothalamus.	Corticosterone	134-148	arginine vasopressin	Rattus norvegicus	203-206
1914160-4	1991	CRH-induced seizures occurred prior to any changes in serum corticosterone, and were eliminated by the administration of a CRH antagonist, as well as of phenytoin.	Corticosterone	60-74	corticotropin releasing hormone	Rattus norvegicus	0-3
1837482-5	1991	IL-1ra at 20 micrograms/mouse completely blocked induction of IL-6 and markedly inhibited hypoglycemia and increase in serum corticosterone induced by 0.1 micrograms of IL-1.	Corticosterone	125-139	interleukin 1 complex	Mus musculus	0-4
1647309-0	1991	Interleukin-1 beta enhances corticosterone secretion by acting directly on the rat adrenal gland.	Corticosterone	28-42	interleukin 1 beta	Rattus norvegicus	0-18
1647309-3	1991	IL-1 beta was found to dose-dependently (4-8 micrograms/kg) raise corticosterone (B) blood concentration in hypophysectomized rats, without inducing any significant increase in the level of circulating ACTH.	Corticosterone	66-80	interleukin 1 beta	Rattus norvegicus	0-9
1654152-2	1991	PAF induces a rapid increase in plasma ACTH and beta endorphin followed by an increase in plasma corticosterone in conscious rats.	Corticosterone	97-111	PCNA clamp associated factor	Rattus norvegicus	0-3
1654152-16	1991	These results suggest that PAF acts, in vivo, on ACTH and corticosterone secretion, through a centrally mediated CRF dependent mechanism involving PAF receptor sites.	Corticosterone	58-72	PCNA clamp associated factor	Rattus norvegicus	27-30
1885393-2	1991	The first experiment was designed to determine the effects of corticosterone alone on basal concentrations of IGF-I.	Corticosterone	62-76	insulin-like growth factor 1	Rattus norvegicus	110-115
1885393-5	1991	Plasma concentrations of IGF-I showed a positive relationship to dose and plasma concentrations of corticosterone and a negative relationship to growth rate.	Corticosterone	99-113	insulin-like growth factor 1	Rattus norvegicus	25-30
2069858-6	1991	[3H]corticosterone binding with disc electrophoresis, run at 2 degrees C, gave a single peak with approximately the same Rf value for rat serum, purified CBG, and adrenal incubate; at 22 degrees C peaks were only seen for rat serum or purified CBG.	Corticosterone	4-18	serpin family A member 6	Rattus norvegicus	154-157
2069858-6	1991	[3H]corticosterone binding with disc electrophoresis, run at 2 degrees C, gave a single peak with approximately the same Rf value for rat serum, purified CBG, and adrenal incubate; at 22 degrees C peaks were only seen for rat serum or purified CBG.	Corticosterone	4-18	serpin family A member 6	Rattus norvegicus	244-247
2069858-9	1991	It is possible that the adrenal protein may be CBG that has been internalized, modified and released with corticosterone.	Corticosterone	106-120	serpin family A member 6	Rattus norvegicus	47-50
1652109-1	1991	To study the role of corticotropin-releasing hormone (CRH) in the circadian rhythm of circulating corticotropin (ACTH), beta-endorphin (beta-END), corticosterone, and prolactin (PRL), we measured the effects of CRH immunoneutralization over a 24-hour period in chronically cannulated, conscious, freely moving, male Sprague-Dawley rats, maintained at a constant light-dark cycle.	Corticosterone	147-161	corticotropin releasing hormone	Rattus norvegicus	54-57
1884244-1	1991	Pyramidal neurons in the rat CA1 hippocampal area contain intracellular receptors for the steroid hormone corticosterone, and membrane associated alpha- and beta-adrenergic receptors.	Corticosterone	106-120	carbonic anhydrase 1	Rattus norvegicus	29-32
1884244-6	1991	Occupation of receptors for corticosterone in the hippocampal CA1 area may therefore potentially lead to suppression of excitability.	Corticosterone	28-42	carbonic anhydrase 1	Rattus norvegicus	62-65
1851181-5	1991	ACTH injection produced significant increases in plasma cortisol, plasma corticosterone, plasma 18-OHB, and PA (P less than 0.005 or P less than 0.001), and graded AII infusions produced significant increases in plasma 18-OHB and PA (P less than 0.05 or P less than 0.01) during both 170- and 100-mmol sodium intakes in the two groups.	Corticosterone	73-87	proopiomelanocortin	Homo sapiens	0-4
19912802-1	1991	Transforming growth factor-beta1 (TGF-beta1) was cloned from a rat hippocampal cDNA library by differential screening as a mRNA that was decreased by corticosterone (CORT) treatment.	Corticosterone	150-164	transforming growth factor, beta 1	Rattus norvegicus	0-32
19912802-1	1991	Transforming growth factor-beta1 (TGF-beta1) was cloned from a rat hippocampal cDNA library by differential screening as a mRNA that was decreased by corticosterone (CORT) treatment.	Corticosterone	150-164	transforming growth factor, beta 1	Rattus norvegicus	34-43
19912802-1	1991	Transforming growth factor-beta1 (TGF-beta1) was cloned from a rat hippocampal cDNA library by differential screening as a mRNA that was decreased by corticosterone (CORT) treatment.	Corticosterone	150-164	cortistatin	Rattus norvegicus	166-170
1658675-1	1991	Polypeptide YY (PYY), a 36-amino-acid peptide contained in high concentration in the chromaffin granules of adrenal medullary cells, significantly raised aldosterone (but not corticosterone) plasma level, when acutely administered intraperitoneum to rats at a dose of 25 microM.kg-1.	Corticosterone	175-189	peptide YY	Rattus norvegicus	0-14
2052554-2	1991	P450c11 converts deoxycorticosterone to corticosterone and aldosterone, and P450scc converts cholesterol to pregnenolone.	Corticosterone	22-36	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	0-7
1645765-8	1991	In contrast, vasopressin-stimulated ACTH release was inhibited by approximately 50% when corticosterone was applied before, or simultaneously with, a 5-min pulse of 10 nmol vasopressin/l.	Corticosterone	89-103	arginine vasopressin	Rattus norvegicus	13-24
1876235-9	1991	In all the stress situations studied the increase in DOPAC level, particularly in the A1/C1 group always preceded or was concomitant to the increase of plasma corticosterone.	Corticosterone	159-173	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	86-91
1657315-5	1991	Similarly, CRH (1 and 10 micrograms/kg IV) did not affect plasma alpha-MSH, whereas it stimulated ACTH and corticosterone release.	Corticosterone	107-121	corticoliberin	Oryctolagus cuniculus	11-14
1828176-7	1991	ANF inhibits the formation of pregnenolone, the steps between progesterone and deoxycorticosterone, deoxycorticosterone and corticosterone and finally, corticosterone and aldosterone with ED50 of 114 +/- 17, 199 +/- 90, 14 +/- 3 and 92 +/- 34 pM of ANF, respectively, and around 70% of inhibition.	Corticosterone	84-98	natriuretic peptide A	Homo sapiens	0-3
1828176-7	1991	ANF inhibits the formation of pregnenolone, the steps between progesterone and deoxycorticosterone, deoxycorticosterone and corticosterone and finally, corticosterone and aldosterone with ED50 of 114 +/- 17, 199 +/- 90, 14 +/- 3 and 92 +/- 34 pM of ANF, respectively, and around 70% of inhibition.	Corticosterone	105-119	natriuretic peptide A	Homo sapiens	0-3
1826128-11	1991	In addition, IL-1ra and 35F5 significantly blocked the ability of IL-1 to stimulate egress of PMN from bone marrow, to induce a transient neutrophilia, and to elevate serum levels of hepatic acute phase proteins, IL-6, and corticosterone.	Corticosterone	223-237	interleukin 1 receptor antagonist	Mus musculus	13-19
1850357-0	1991	Effects of short and long duration hypothyroidism and hyperthyroidism on the plasma adrenocorticotropin and corticosterone responses to ovine corticotropin-releasing hormone in rats.	Corticosterone	108-122	corticotropin releasing hormone	Rattus norvegicus	142-173
1850357-1	1991	We report here a study of the plasma ACTH and corticosterone responses to synthetic ovine CRH (oCRH) in hypothyroid and hyperthyroid rats studied 7, 15, and 60 days after either thyroidectomy or the administration of pharmacological doses of T4.	Corticosterone	46-60	corticotropin releasing hormone	Rattus norvegicus	90-93
1713525-3	1991	At least two types of receptors for corticosterone have been recognized in the rat brain, type I (corticosterone preferring receptor, CR) and type II (glucocorticoid receptor, GR).	Corticosterone	36-50	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	90-179
1647798-8	1991	The concomitant icv infusion of corticosterone, which is thought to be the primary ligand of the brain mineralocorticoid receptor, antagonizes the effect of icv infusion of aldosterone.	Corticosterone	32-46	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	103-129
1675439-0	1991	Somatostatin in the hippocampus mediates dexamethasone-induced suppression of corticosterone secretion in the rat.	Corticosterone	78-92	somatostatin	Rattus norvegicus	0-12
1675439-4	1991	Additionally, anti-SS gamma-globulins, infused under stereotaxic control into two discrete areas of the hippocampus (CA3 and DG), completely blocked Dex-induced inhibition of corticosterone secretion.	Corticosterone	175-189	carbonic anhydrase 3	Rattus norvegicus	117-120
1826128-11	1991	In addition, IL-1ra and 35F5 significantly blocked the ability of IL-1 to stimulate egress of PMN from bone marrow, to induce a transient neutrophilia, and to elevate serum levels of hepatic acute phase proteins, IL-6, and corticosterone.	Corticosterone	223-237	interleukin 1 complex	Mus musculus	13-17
1645434-2	1991	The results demonstrate that the PPT mRNA is regulated by glucocorticoids such that adrenalectomized (ADX) animals replaced with corticosterone for 5 days expressed higher levels of the mRNA than ADX animals.	Corticosterone	129-143	tachykinin, precursor 1	Rattus norvegicus	33-36
1850248-6	1991	The transformation of corticosterone under angiotensin II stimulation yielded up to 41% of 18-hydroxycorticosterone (4.7 micrograms/mg of cell protein per 24h) and 4.4% of aldosterone (0.5 microgram/mg of cell protein per 24h) in a low potassium concentration medium (6 mmol/l).	Corticosterone	22-36	angiotensinogen	Rattus norvegicus	43-57
1645434-3	1991	The corticosterone-induced increase in striatal PPT mRNA was evident after 16 h, but not after 2 h, of corticosterone treatment of ADX animals.	Corticosterone	4-18	tachykinin, precursor 1	Rattus norvegicus	48-51
1645434-3	1991	The corticosterone-induced increase in striatal PPT mRNA was evident after 16 h, but not after 2 h, of corticosterone treatment of ADX animals.	Corticosterone	103-117	tachykinin, precursor 1	Rattus norvegicus	48-51
1999179-6	1991	A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1.	Corticosterone	65-79	interleukin 1 complex	Mus musculus	35-39
1999179-5	1991	We investigated the possible roles of changes in serum corticosterone and glucose in the effects of LPS, TNF and IL-1.	Corticosterone	55-69	interleukin 1 complex	Mus musculus	113-117
1999179-6	1991	A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1.	Corticosterone	65-79	tumor necrosis factor	Mus musculus	156-159
1999179-6	1991	A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1.	Corticosterone	65-79	tumor necrosis factor	Mus musculus	27-30
1999179-6	1991	A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1.	Corticosterone	65-79	tumor necrosis factor	Mus musculus	156-159
1999179-6	1991	A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1.	Corticosterone	198-212	tumor necrosis factor	Mus musculus	27-30
1999179-6	1991	A single injection of LPS, TNF, or IL-1 markedly increased serum corticosterone levels after 2 h. After only 2 days of chronic treatment, mice given LPS or TNF were refractory to induction of serum corticosterone by a subsequent injection of LPS or TNF, but mice given IL-1 for 2 days were still fully responsive to IL-1.	Corticosterone	198-212	interleukin 1 complex	Mus musculus	35-39
1999179-9	1991	This lack of adaptation to the increase of serum corticosterone and hypoglycemia was also observed when IL-1 was given at lower, nonlethal doses (0.25-1.0 microgram) and for a longer period (up to 8 days).	Corticosterone	49-63	interleukin 1 complex	Mus musculus	104-108
1992764-15	1991	In contrast, IL-1 levels rose concurrently with corticosterone.	Corticosterone	48-62	interleukin 1 complex	Mus musculus	13-17
1989849-6	1991	The maximal inhibition of fibronectin secretion was 45% at 24 h and 70% at 96 h with 1000 nM corticosterone.	Corticosterone	93-107	fibronectin 1	Rattus norvegicus	26-37
1846581-0	1991	Corticotropin-releasing hormone (CRH) directly stimulates corticosterone secretion by the rat adrenal gland.	Corticosterone	58-72	corticotropin releasing hormone	Rattus norvegicus	0-31
1846581-0	1991	Corticotropin-releasing hormone (CRH) directly stimulates corticosterone secretion by the rat adrenal gland.	Corticosterone	58-72	corticotropin releasing hormone	Rattus norvegicus	33-36
1846581-1	1991	Corticotropin-releasing hormone (CRH) acute ip administration (10 micrograms) significantly increased the blood concentration of corticosterone (B) in hypophysectomized rats, without inducing any rise in the level of circulating ACTH.	Corticosterone	129-143	corticotropin releasing hormone	Rattus norvegicus	0-31
1846581-1	1991	Corticotropin-releasing hormone (CRH) acute ip administration (10 micrograms) significantly increased the blood concentration of corticosterone (B) in hypophysectomized rats, without inducing any rise in the level of circulating ACTH.	Corticosterone	129-143	corticotropin releasing hormone	Rattus norvegicus	33-36
1989849-9	1991	At 24 and 96 h, 1000 nM corticosterone produced a decrease of 42% and 62%, respectively, in fibronectin mRNA levels.	Corticosterone	24-38	fibronectin 1	Rattus norvegicus	92-103
1852030-5	1991	Corticosterone levels were increased by 112% to 146% following infusion of the three different CRF doses, CGRP and NP (P less than 0.001 vs. controls), and by 240% after VIP (P less than 0.001 vs. other treatments).	Corticosterone	0-14	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
1852030-5	1991	Corticosterone levels were increased by 112% to 146% following infusion of the three different CRF doses, CGRP and NP (P less than 0.001 vs. controls), and by 240% after VIP (P less than 0.001 vs. other treatments).	Corticosterone	0-14	vasoactive intestinal peptide	Rattus norvegicus	170-173
1645674-2	1991	alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects.	Corticosterone	245-259	proopiomelanocortin	Homo sapiens	0-36
19215444-4	1991	In hippocampal, but not cortical, membranes the adenylate cyclase response to calmodulin was higher during the beginning of the dark phase of the cycle, when endogenous corticosterone levels are high.	Corticosterone	169-183	calmodulin 1	Homo sapiens	78-88
19215444-12	1991	Taken together with our recent finding that chronic stress or corticosterone injection selectively attenuated the adenylate cyclase response to calmodulin in cortical, but not hippocampal membranes our findings provide further support for a role of the pituitary-adrenal axis in modulating neural calmodulin-dependent adenylate cyclase activity.	Corticosterone	62-76	calmodulin 1	Homo sapiens	144-154
19215444-12	1991	Taken together with our recent finding that chronic stress or corticosterone injection selectively attenuated the adenylate cyclase response to calmodulin in cortical, but not hippocampal membranes our findings provide further support for a role of the pituitary-adrenal axis in modulating neural calmodulin-dependent adenylate cyclase activity.	Corticosterone	62-76	calmodulin 1	Homo sapiens	297-307
1645674-2	1991	alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects.	Corticosterone	245-259	proopiomelanocortin	Homo sapiens	38-47
1645674-2	1991	alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects.	Corticosterone	245-259	interleukin 1 alpha	Homo sapiens	138-142
1645674-2	1991	alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects.	Corticosterone	245-259	proopiomelanocortin	Homo sapiens	185-194
1645674-2	1991	alpha-Melanocyte-stimulating hormone (alpha-MSH) introduced into the ventricular system simultaneously with IL-1 blocked these effects of IL-1 in a dose-dependent manner, with 10 ng of alpha-MSH totally blocking the elevation of plasma ACTH and corticosterone and suppression of Natural Killer (NK) cell activity produced by a dose of IL-1 (100 pg) that otherwise causes maximal effects.	Corticosterone	245-259	interleukin 1 alpha	Homo sapiens	138-142
1719873-0	1991	Substance P afferents regulate ACTH-corticosterone release.	Corticosterone	36-50	tachykinin precursor 1	Homo sapiens	0-11
1708470-2	1991	In the pineal gland, hypoglycemic stress caused dramatic decrease of 5-HT, resulted in initial decrease followed by an increase of 5-HIAA and brought about changes of NE and E. Corticosterone content in the adrenal gland increased significantly following treatment with insulin.	Corticosterone	177-191	insulin	Gallus gallus	270-277
2053445-11	1991	The present results suggest that corticosterone treatment can abolish the centrally evoked vasodepressor responses to close to maximal doses of adrenaline and neuropeptide Y, which may contribute to their hypertensive properties in man.	Corticosterone	33-47	neuropeptide Y	Homo sapiens	159-173
1719873-0	1991	Substance P afferents regulate ACTH-corticosterone release.	Corticosterone	36-50	proopiomelanocortin	Homo sapiens	31-35
2018462-6	1991	A 2-min exposure to either vapor induced an elevation in adrenal concentration of corticosterone which was significantly greater in SHA than SLA animals of both sexes at some time periods following the ether stress.	Corticosterone	82-96	src-like adaptor	Rattus norvegicus	141-144
1863673-1	1991	During chromatography of renal tissue cytosolic proteins on DEAE-cellulose the protein specifically binding [3H]corticosterone is eluted within the potassium phosphate concentration range of 0.08-0.10 M. Analysis of kidney slices revealed the synthesis of [3H]transcortin whose electrophoretic mobility was close to that of the blood plasma protein.	Corticosterone	112-126	serpin family A member 6	Rattus norvegicus	260-271
1668712-5	1991	However, the binding capacity of CBG increased with age which led to a decrease in the pool of active corticosterone in the blood.	Corticosterone	102-116	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	33-36
1668712-7	1991	(The number of binding sites increased from 0.64 +/- 0.05 to 0.8 +/- 0.03 microM and the values of the association constant for the binding of corticosterone to CBG increased from 0.29 +/- 0.05 to 0.91 +/- 0.07 microM-1).	Corticosterone	143-157	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	161-164
1904300-1	1991	Modulation of CA1 evoked electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of aldosterone (ALDO), spironolactone (SPI), and corticosterone (CT) was studied in hippocampal slice preparation from BALB/c mice.	Corticosterone	182-196	carbonic anhydrase 1	Mus musculus	14-17
1904300-1	1991	Modulation of CA1 evoked electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of aldosterone (ALDO), spironolactone (SPI), and corticosterone (CT) was studied in hippocampal slice preparation from BALB/c mice.	Corticosterone	198-200	carbonic anhydrase 1	Mus musculus	14-17
1665802-1	1991	Weekly infusion with arginine vasopressin (AVP) (2 micrograms.kg-1.day-1) exerted a slight stimulatory effect on the adrenal growth of intact female rats and induced a 2-fold rise in plasma aldosterone concentration (PAC), without apparently affecting corticosterone (B) and ACTH secretions.	Corticosterone	252-266	arginine vasopressin	Rattus norvegicus	30-41
1648453-1	1991	Intracerebroventricular (ICV) injections of interleukin-1 beta (IL-1 beta) produced a dose-dependent increase in plasma corticosterone and adrenocorticotropic hormone (ACTH) within 2 hr of injection and then declined over the next 24 hr.	Corticosterone	120-134	interleukin 1 beta	Rattus norvegicus	44-62
1648453-1	1991	Intracerebroventricular (ICV) injections of interleukin-1 beta (IL-1 beta) produced a dose-dependent increase in plasma corticosterone and adrenocorticotropic hormone (ACTH) within 2 hr of injection and then declined over the next 24 hr.	Corticosterone	120-134	interleukin 1 beta	Rattus norvegicus	64-73
1846109-2	1991	The addition of rat interleukin-1 alpha (IL-1 alpha) or rat IL-2 increased corticosterone levels in the medium in a concentration-dependent manner during 24 h of incubation.	Corticosterone	75-89	interleukin 1 alpha	Rattus norvegicus	20-39
1846109-2	1991	The addition of rat interleukin-1 alpha (IL-1 alpha) or rat IL-2 increased corticosterone levels in the medium in a concentration-dependent manner during 24 h of incubation.	Corticosterone	75-89	interleukin 1 alpha	Rattus norvegicus	41-51
1846109-2	1991	The addition of rat interleukin-1 alpha (IL-1 alpha) or rat IL-2 increased corticosterone levels in the medium in a concentration-dependent manner during 24 h of incubation.	Corticosterone	75-89	interleukin 2	Rattus norvegicus	60-64
1846109-5	1991	Human IL-1 beta and human IL-6 also showed a stimulatory effect on corticosterone production, whereas human IL-2 was inactive in this system.	Corticosterone	67-81	interleukin 1 beta	Homo sapiens	6-15
1846109-5	1991	Human IL-1 beta and human IL-6 also showed a stimulatory effect on corticosterone production, whereas human IL-2 was inactive in this system.	Corticosterone	67-81	interleukin 6	Homo sapiens	26-30
1846109-7	1991	Corticosterone production stimulated by IL-1 alpha or IL-2 was accompanied by intracellular and extracellular cAMP and PGE2 accumulation.	Corticosterone	0-14	interleukin 1 alpha	Rattus norvegicus	40-50
1846109-7	1991	Corticosterone production stimulated by IL-1 alpha or IL-2 was accompanied by intracellular and extracellular cAMP and PGE2 accumulation.	Corticosterone	0-14	interleukin 2	Rattus norvegicus	54-58
1665802-1	1991	Weekly infusion with arginine vasopressin (AVP) (2 micrograms.kg-1.day-1) exerted a slight stimulatory effect on the adrenal growth of intact female rats and induced a 2-fold rise in plasma aldosterone concentration (PAC), without apparently affecting corticosterone (B) and ACTH secretions.	Corticosterone	252-266	arginine vasopressin	Rattus norvegicus	43-46
1650334-10	1991	Elevated corticosterone has been reported to inhibit IL-2 production and impair immunocompetence.	Corticosterone	9-23	interleukin 2	Mus musculus	53-57
1659882-8	1991	Similarly, the PLA2 inhibitors quinacrine, dexamethasone and corticosterone, added to the Leydig cells in vitro, inhibited LH-stimulated testosterone production but not cyclic AMP production.	Corticosterone	61-75	phospholipase A2 group IB	Rattus norvegicus	15-19
1659884-1	1991	Pyramidal neurons in the rat CA1 hippocampal area contain both mineralocorticoid (MR) and glucocorticoid receptors (GR) which bind the endogenous adrenal steroid corticosterone with differential affinity.	Corticosterone	162-176	carbonic anhydrase 1	Rattus norvegicus	29-32
1659887-3	1991	We have compared the relative potencies of the cytokines IL-1, IL-6 and tumor necrosis factor (TNF), which share several biological actions, for stimulating ACTH and corticosterone output in freely-moving rats.	Corticosterone	166-180	tumor necrosis factor-like	Rattus norvegicus	72-93
1659887-3	1991	We have compared the relative potencies of the cytokines IL-1, IL-6 and tumor necrosis factor (TNF), which share several biological actions, for stimulating ACTH and corticosterone output in freely-moving rats.	Corticosterone	166-180	tumor necrosis factor-like	Rattus norvegicus	95-98
1997123-1	1991	The [3H]corticosterone-transcortin complexes from kidney cytosol show elution positions on DEAE-cellulose identical to serum transcortin.	Corticosterone	8-22	serpin family A member 6	Rattus norvegicus	23-34
1997123-1	1991	The [3H]corticosterone-transcortin complexes from kidney cytosol show elution positions on DEAE-cellulose identical to serum transcortin.	Corticosterone	8-22	serpin family A member 6	Rattus norvegicus	125-136
1646364-2	1991	Intravenous bolus injection of 1000 pmol/kg of ET-3 in freely moving rats caused significant increases in plasma ACTH and corticosterone levels, almost equivalent to those of 100 pmol/kg of rat corticotropin-releasing hormone (rCRH).	Corticosterone	122-136	endothelin 3	Rattus norvegicus	47-51
1646364-5	1991	The results indicate that ET-3 may function as a neuropeptide and stimulation of the CRH-neurons, direct or inderect, is mainly responsible for activation of ACTH and corticosterone release.	Corticosterone	167-181	endothelin 3	Rattus norvegicus	26-30
1646364-5	1991	The results indicate that ET-3 may function as a neuropeptide and stimulation of the CRH-neurons, direct or inderect, is mainly responsible for activation of ACTH and corticosterone release.	Corticosterone	167-181	corticotropin releasing hormone	Rattus norvegicus	85-88
1997790-2	1991	The aim of the present study was to examine both the prolactin (PRL) and corticosterone (CORT) responses to a short period of restraint stress after the animals had been made diabetic for six weeks.	Corticosterone	73-87	cortistatin	Rattus norvegicus	89-93
2057538-4	1991	A significant increase was also detected in the adrenals; here, the time course of DBI increase paralleled that of previously reported plasma corticosterone in stressed rats, being significantly higher 30 min after stress, and recovering to normal values at 60 and 90 min.	Corticosterone	142-156	diazepam binding inhibitor	Rattus norvegicus	83-86
1843208-4	1991	Therefore, it may be concluded that the decrease in GR binding capacity and GR mRNA in intact rats after the scalding stress is mainly the result of the increased concentration of serum corticosterone.	Corticosterone	186-200	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	52-54
1843208-4	1991	Therefore, it may be concluded that the decrease in GR binding capacity and GR mRNA in intact rats after the scalding stress is mainly the result of the increased concentration of serum corticosterone.	Corticosterone	186-200	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	76-78
1981046-9	1990	The presence of high corticosterone levels in the home cage after postdefeat ipsapirone treatment leads to the hypothesis that postsynaptic 5-HT 1A receptor hypersensitivity develops after the social stress of defeat.	Corticosterone	21-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	140-147
19215427-0	1990	Negative Feedback by Corticosterone is the Major Mechanism Responsible for Corticotropin-Releasing Factor-Induced Desensitization.	Corticosterone	21-35	corticotropin releasing hormone	Rattus norvegicus	75-105
2082191-4	1990	By investigating the effects of insulin, IGF-I, T3, and corticosterone, alone or in combinations, in the presence or absence of GH we concluded that GH is indeed the inducer of P-450(15)beta mRNA and IGF-I mRNA.	Corticosterone	56-70	gonadotropin releasing hormone receptor	Rattus norvegicus	149-151
2126613-0	1990	Corticotropin-releasing factor concentrations exhibit an apparent diurnal rhythm in hypothalamic and extrahypothalamic brain regions: differential sensitivity to corticosterone.	Corticosterone	162-176	corticotropin releasing hormone	Rattus norvegicus	0-30
2256920-5	1990	However, they are distinctly different from each other in that P-450aldo preferentially catalyzes the conversion of 11-deoxycorticosterone to aldosterone via corticosterone and 18-hydroxycorticosterone while P-450(11)beta substantially fails to catalyze the reaction to form aldosterone.	Corticosterone	124-138	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	63-72
2257238-6	1990	In rats, LHRH-, ACTH- and sodium-deprived diet stimulated plasma testosterone, corticosterone and aldosterone levels were not modified 2 h after single oral administrations of R76713 (up to 20 mg/kg).	Corticosterone	79-93	gonadotropin releasing hormone 1	Rattus norvegicus	9-13
2257242-3	1990	In the hippocampus MR binds corticosterone (CORT) as well as aldosterone (ALDO) with high affinity.	Corticosterone	28-42	cortistatin	Homo sapiens	44-48
1963847-4	1990	Administration of the 5-HT1A agonists, 8-OH-DPAT (1 mg/kg) and ipsapirone (4 mg/kg), to rats resulted in activation of the HPA axis as evidenced by increased plasma ACTH and corticosterone concentrations in acutely treated rats and increased plasma corticosterone concentrations in both acutely and chronically treated rats.	Corticosterone	174-188	5-hydroxytryptamine receptor 1A	Rattus norvegicus	22-28
1963847-4	1990	Administration of the 5-HT1A agonists, 8-OH-DPAT (1 mg/kg) and ipsapirone (4 mg/kg), to rats resulted in activation of the HPA axis as evidenced by increased plasma ACTH and corticosterone concentrations in acutely treated rats and increased plasma corticosterone concentrations in both acutely and chronically treated rats.	Corticosterone	249-263	5-hydroxytryptamine receptor 1A	Rattus norvegicus	22-28
2119298-3	1990	Graded doses of ET-1 from 10(-11)-10(-9) M stimulated both corticosterone and aldosterone production in a dose-dependent manner.	Corticosterone	59-73	endothelin 1	Homo sapiens	16-20
1748564-1	1991	Using in situ hybridization, localization of the gene transcripts of 11 beta-hydroxylase and aldosterone synthase was investigated in order to clarify the sites for the synthesis of corticosterone (glucocorticoid) and aldosterone (mineralocorticoid) in the rat adrenal cortex.	Corticosterone	182-196	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	93-113
2289159-2	1990	To determine if endogenous corticosterone affects the level of NPY mRNA in areas that control NPY levels in the paraventricular nucleus, we examined the effects of adrenalectomy and corticosterone replacement on NPY mRNA levels in the arcuate nucleus and brainstem.	Corticosterone	27-41	neuropeptide Y	Rattus norvegicus	63-66
2289159-6	1990	Adrenalectomy significantly reduced NPY mRNA levels in the arcuate nucleus, while corticosterone replacement restored the NPY mRNA levels.	Corticosterone	82-96	neuropeptide Y	Rattus norvegicus	122-125
2172271-7	1990	The ACTH-dependent secretion of the C-18 oxidation products of both corticosterone and cortisol in the disorder is attributed to the acquisition of methyl oxidase activity by the fasciculata zone, where there are abundant pools of these precursors.	Corticosterone	68-82	Bardet-Biedl syndrome 9	Homo sapiens	36-40
2213026-5	1990	Chronic administration of corticosterone (7 days) significantly increased levels of mRNA for ARF1 and ARF3, two subtypes of ARF, in rat cerebral cortex.	Corticosterone	26-40	ADP-ribosylation factor 1	Rattus norvegicus	93-97
2213026-5	1990	Chronic administration of corticosterone (7 days) significantly increased levels of mRNA for ARF1 and ARF3, two subtypes of ARF, in rat cerebral cortex.	Corticosterone	26-40	ADP-ribosylation factor 3	Rattus norvegicus	102-106
2213026-8	1990	In contrast to corticosterone, bilateral adrenalectomy (7 days after surgery) was found to decrease ARF1 and ARF3 message relative to sham controls; this effect of adrenalectomy was reversed by corticosterone treatment.	Corticosterone	194-208	ADP-ribosylation factor 1	Rattus norvegicus	100-104
2213026-8	1990	In contrast to corticosterone, bilateral adrenalectomy (7 days after surgery) was found to decrease ARF1 and ARF3 message relative to sham controls; this effect of adrenalectomy was reversed by corticosterone treatment.	Corticosterone	194-208	ADP-ribosylation factor 3	Rattus norvegicus	109-113
2087473-2	1990	A single administration of thymosin at a dose of 1 micrograms/mouse causes a rise of the blood level of corticosterone in 3 h. Dexamethasone, a blocker of ACTH secretion, stops the thymosin effect.	Corticosterone	104-118	pro-opiomelanocortin-alpha	Mus musculus	155-159
1705153-2	1990	Daily injection of 10 mg of corticosterone for 21 days resulted in decreased numbers of apical dendritic branch points and decreased total apical dendritic length measured in a 100-microns-thick section in CA3 pyramidal cells compared to sham-injected and non-injected controls.	Corticosterone	28-42	carbonic anhydrase 3	Rattus norvegicus	206-209
1705153-6	1990	Finally, qualitative analysis of Nissl-stained tissue from the same brains revealed increased numbers of darkly staining, apparently shrunken CA3 pyramidal cells in corticosterone treated compared to control brains.	Corticosterone	165-179	carbonic anhydrase 3	Rattus norvegicus	142-145
1705153-7	1990	The changes in dendritic morphology we have observed may be indicative of neurons in the early stages of degeneration, as prolonged exposure to high levels of corticosterone has been shown by others to result in a loss of CA3 pyramidal cells.	Corticosterone	159-173	carbonic anhydrase 3	Rattus norvegicus	222-225
1981163-8	1990	Neurotensin injection markedly decreased serum prolactin levels and increased serum corticosterone levels by about 60%, whereas serum levels of luteinizing hormone were unaffected.	Corticosterone	84-98	neurotensin	Rattus norvegicus	0-11
2176727-4	1990	injections of mEGF (5-20 ng: 8.3-33.3 pmol) produced significant, dose-related increases in plasma ACTH and corticosterone concentrations.	Corticosterone	108-122	epidermal growth factor	Mus musculus	14-18
2119298-9	1990	The cyclooxygenase inhibitor indomethacin (5 microM) totally suppressed the stimulatory effect of ET-1 on corticosterone and aldosterone secretion; in contrast, indomethacin did not affect ACTH-evoked corticosteroid secretion.	Corticosterone	106-120	endothelin 1	Homo sapiens	98-102
2119298-11	1990	These results demonstrate that ET-1 is a potent stimulator of corticosterone and aldosterone secretion from frog adrenal gland in vitro.	Corticosterone	62-76	endothelin 1	Homo sapiens	31-35
2119298-5	1990	Prolonged administration (3 h) of ET-1 induced a rapid increase in corticosterone and aldosterone output, followed by a gradual decline of corticosteroid secretion.	Corticosterone	67-81	endothelin 1	Homo sapiens	34-38
19912768-1	1990	The ability of immature (21-day-old) rats to release ACTH and corticosterone (CORT) in response to stress is known to be enhanced by in utero exposure to ethanol (EtOH).	Corticosterone	62-76	cortistatin	Rattus norvegicus	78-82
1697591-0	1990	Adipose conversion of 3T3-L1 cells in a serum-free culture system depends on epidermal growth factor, insulin-like growth factor I, corticosterone, and cyclic AMP.	Corticosterone	132-146	WD and tetratricopeptide repeats 1	Mus musculus	0-7
1697591-3	1990	1) In the presence of high insulin concentrations (1 microM), addition of corticosterone together with 1-methyl-3-isobutylxanthine (MIX) for not more than the first 4 days after confluence to the culture medium induces maximal adipose conversion within 12-14 days.	Corticosterone	74-88	WD and tetratricopeptide repeats 1	Mus musculus	227-234
1697591-6	1990	Growth hormone or insulin-like growth factor I together with epidermal growth factor have to be present as a medium supplement together with corticosterone and MIX to get maximal adipose conversion.	Corticosterone	141-155	insulin-like growth factor 1	Mus musculus	18-46
1697591-6	1990	Growth hormone or insulin-like growth factor I together with epidermal growth factor have to be present as a medium supplement together with corticosterone and MIX to get maximal adipose conversion.	Corticosterone	141-155	WD and tetratricopeptide repeats 1	Mus musculus	179-186
1697591-7	1990	3) The induction of adipose conversion by corticosterone and MIX in the presence of either high insulin concentrations or insulin-like growth factor I together with epidermal growth factor is accompanied by post-confluent mitoses.	Corticosterone	42-56	WD and tetratricopeptide repeats 1	Mus musculus	20-27
1697591-7	1990	3) The induction of adipose conversion by corticosterone and MIX in the presence of either high insulin concentrations or insulin-like growth factor I together with epidermal growth factor is accompanied by post-confluent mitoses.	Corticosterone	42-56	insulin-like growth factor 1	Mus musculus	122-150
2226278-9	1990	On the other hand, a single dose of corticosterone (100 micrograms/100 g) as well as long-term corticosterone treatment (100 micrograms/ml saline as drinking solution for 6 days) reduced the glucocorticoid receptor concentration only to 60% and 25%, respectively.	Corticosterone	36-50	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	191-214
2226278-9	1990	On the other hand, a single dose of corticosterone (100 micrograms/100 g) as well as long-term corticosterone treatment (100 micrograms/ml saline as drinking solution for 6 days) reduced the glucocorticoid receptor concentration only to 60% and 25%, respectively.	Corticosterone	95-109	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	191-214
2170767-4	1990	Expressed as stimulated level/control level ratios, glucocorticoid (cortisol + corticosterone) responses to IGF I after 4 days" culture (2.41 +/- 0.20 (SEM) n = 9) were similar to those obtained with ACTH (2.59 +/- 0.18, n = 9).	Corticosterone	79-93	insulin like growth factor 1	Bos taurus	108-113
2170767-6	1990	The cortisol/corticosterone ratio increased in the presence of IGF I from 1 +/- 0.19 to 1.76 +/- 0.45 (n = 7, P less than 0.02), although less so than in the presence of ACTH (5.50 +/- 0.98).	Corticosterone	13-27	insulin like growth factor 1	Bos taurus	63-68
2369744-2	1990	Ketoconazole, a potent but transient inhibitor of adrenal steroid hormone biosynthesis, inhibited IL-1 alpha induced increases in plasma corticosterone.	Corticosterone	137-151	interleukin 1 alpha	Mus musculus	98-108
2369744-8	1990	The effect of elevated plasma corticosterone levels, induced by ketamine-acepromazine anesthesia, on IL-1 alpha responsiveness was also studied in the RIF-1 tumor model.	Corticosterone	30-44	interleukin 1 alpha	Mus musculus	101-111
2148812-1	1990	The serum corticosterone concentration in rats was increased by injection of quipazine, a relatively nonselective serotonin (5-hydroxytryptamine; 5-HT) agonist, or 8-hydroxy-2-(di-n- propylamino)tetralin (8-OH-DPAT), a serotonin agonist selective for the 5-HT1A subtype of receptor.	Corticosterone	10-24	5-hydroxytryptamine receptor 1A	Rattus norvegicus	255-261
2245817-1	1990	The present study was undertaken to investigate the importance of corticosterone (CORT) on the ambulatory activity in the ovariectomized (OVX) rats by employing the automatic apparatus for continuous and direct measurement of ambulation.	Corticosterone	66-80	cortistatin	Rattus norvegicus	82-86
2148812-3	1990	The 8-OH-DPAT-induced increase in serum corticosterone was not antagonized by metergoline, the most potent antagonist of the quipazine effect, but was antagonized by pindolol or penbutolol, 5-HT1A receptor antagonists.	Corticosterone	40-54	5-hydroxytryptamine receptor 1A	Rattus norvegicus	190-196
2148812-5	1990	The results support earlier evidence that serum corticosterone concentration in rats can be increased by activation of either 5-HT1A or 5-HT2 receptors.	Corticosterone	48-62	5-hydroxytryptamine receptor 1A	Rattus norvegicus	126-132
2402342-5	1990	Adrenalectomized rats that received replacement corticosterone had levels of NPY message that had returned to the levels found in rats receiving sham operation.	Corticosterone	48-62	neuropeptide Y	Rattus norvegicus	77-80
2382237-6	1990	When TNF was administered together with corticosterone, total and myofibrillar protein breakdown rates were increased further compared with rats treated with corticosterone alone.	Corticosterone	158-172	tumor necrosis factor-like	Rattus norvegicus	5-8
2382237-7	1990	Because plasma corticosterone levels in rats treated with both TNF and the glucocorticoid were higher than in animals treated with corticosterone alone, it is possible that muscle proteolysis noted after TNF, injected together with costicosterone, was caused by the high glucocorticoid levels.	Corticosterone	15-29	tumor necrosis factor-like	Rattus norvegicus	63-66
2164954-0	1990	Neuropeptide Y inhibits corticosterone secretion by isolated rat adrenocortical cells.	Corticosterone	24-38	neuropeptide Y	Rattus norvegicus	0-14
2164954-1	1990	Studies with isolated rat adrenocortical cells have shown that neuropeptide Y (NPY) inhibits both basal and ACTH-stimulated corticosterone secretion.	Corticosterone	124-138	neuropeptide Y	Rattus norvegicus	63-77
2164954-1	1990	Studies with isolated rat adrenocortical cells have shown that neuropeptide Y (NPY) inhibits both basal and ACTH-stimulated corticosterone secretion.	Corticosterone	124-138	neuropeptide Y	Rattus norvegicus	79-82
2164954-2	1990	These results suggest the regulatory role of NPY in corticosterone secretion from the adrenal gland, especially during stress.	Corticosterone	52-66	neuropeptide Y	Rattus norvegicus	45-48
2224524-9	1990	However, daily administration of corticosterone to rats beginning 10 days after adrenalectomy returned hippocampal GPDH activity to normal values after 2-3 days.	Corticosterone	33-47	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	115-119
2164530-1	1990	17 alpha-Hydroxylase deficiency (17-OHDS) is a peculiar type of adrenal insufficiency because of elevated corticosterone (B) production.	Corticosterone	106-120	OHDS	Homo sapiens	36-40
2162378-0	1990	Calmodulin involvement in stress- and corticosterone-induced down-regulation of cyclic AMP-generating systems in brain.	Corticosterone	38-52	calmodulin 1	Rattus norvegicus	0-10
2162378-3	1990	We therefore investigated the effects of stress and corticosterone (CORT) on membrane calmodulin-dependent adenylate cyclase and noradrenaline-stimulated cyclic AMP accumulation in brain slices.	Corticosterone	52-66	calmodulin 1	Rattus norvegicus	86-96
2162378-3	1990	We therefore investigated the effects of stress and corticosterone (CORT) on membrane calmodulin-dependent adenylate cyclase and noradrenaline-stimulated cyclic AMP accumulation in brain slices.	Corticosterone	68-72	calmodulin 1	Rattus norvegicus	86-96
2168227-1	1990	Recombinant IL-1-beta, which is capable of stimulating the pituitary-adrenal axis to secrete corticosterone, was paired with environmental cues in either a taste aversion or odor conditioning procedure.	Corticosterone	93-107	interleukin 1 beta	Mus musculus	12-21
2082201-3	1990	CGRP also caused vasodilation in the adrenal gland, reflected in increased perfusate flow, and also stimulated corticosterone secretion, with a threshold of 0.1 pmol.	Corticosterone	111-125	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2235682-2	1990	ET-1 exerted a dose-dependent stimulation of basal secretion of A and corticosterone (B) by dispersed zona glomerulosa (ZG) cells, while it did not affect B production by inner adrenocortical cells.	Corticosterone	70-84	endothelin 1	Rattus norvegicus	0-4
2238157-2	1990	The differences in the Schtern Folmer constants and the dissociation constants for the transcortin-corticosterone complex obtained during the protein titration by corticosterone may be due to different tryptophanyl surroundings in the molecules of the studied proteins.	Corticosterone	99-113	serpin family A member 6	Rattus norvegicus	87-98
2238157-2	1990	The differences in the Schtern Folmer constants and the dissociation constants for the transcortin-corticosterone complex obtained during the protein titration by corticosterone may be due to different tryptophanyl surroundings in the molecules of the studied proteins.	Corticosterone	163-177	serpin family A member 6	Rattus norvegicus	87-98
2354995-4	1990	Chronic corticosterone administration (subcutaneous injection for 7 days, 10 mg/day) to normal intact rats significantly increased levels of CaBP28k immunoreactivity (43%) and mRNA (125%) in the hippocampus.	Corticosterone	8-22	calbindin 1	Rattus norvegicus	141-148
2354995-7	1990	When adrenalectomized rats were treated with corticosterone (10 mg/day for 7 days), CaBP28k protein and mRNA levels in hippocampus were restored to levels observed in intact controls.	Corticosterone	45-59	calbindin 1	Rattus norvegicus	84-91
1694401-7	1990	Administration of corticosterone three times daily for 3 days dramatically elevated ODC activity and produced significant microscopic damage.	Corticosterone	18-32	ornithine decarboxylase 1	Rattus norvegicus	84-87
2161738-2	1990	Intravenous injections of TNF alpha stimulated plasma ACTH and corticosterone secretion in a dose-dependent fashion.	Corticosterone	63-77	tumor necrosis factor	Rattus norvegicus	26-35
2351107-7	1990	The SIP also stimulated basal and human CG stimulated in vitro progesterone production of human ovarian granulosa-lutein cells and corticosterone production of rat adrenal cells.	Corticosterone	131-145	TSSK6 activating cochaperone	Homo sapiens	4-7
2168227-2	1990	Among mice receiving paired delivery of cues and IL-1, subsequent re-exposure to cues elicited corticosterone production.	Corticosterone	95-109	interleukin 1 complex	Mus musculus	49-53
2349252-14	1990	Hypothesis 1 emphasizes the nearly complete concordance of the RI lines with progenitor phenotypes and proposes that a single Cor gene regulates the distribution of CS-positive cells.	Corticosterone	165-167	distribution of corticosterone in adrenal cortex cells	Mus musculus	126-129
2349252-16	1990	Hypothesis 2, which gives greater weight to the two RI lines with intermediate numbers of CS-positive cells, postulates an epistatic interaction between two Cor loci.	Corticosterone	90-92	distribution of corticosterone in adrenal cortex cells	Mus musculus	157-160
2332444-4	1990	When the ovalbumin-chloramphenicol acetyltransferase fusion genes were transfected into steroid-responsive primary oviduct cells, mutants lacking sequences between -900 and -732 were no longer responsive to estrogen, corticosterone, progesterone, or dihydrotestosterone.	Corticosterone	217-231	ovalbumin (SERPINB14)	Gallus gallus	9-18
2139180-4	1990	Recombinant IRAP specifically inhibited IL-1 bioactivity on T cells and endothelial cells in vitro and was a potent inhibitor of IL-1 induced corticosterone production in vivo.	Corticosterone	142-156	interleukin 1 receptor antagonist	Homo sapiens	12-16
2357595-2	1990	We have previously cloned hippocampal mRNAs that respond to the endogenous glucocorticoid, corticosterone (CORT): glycerol phosphate dehydrogenase (EC 1.1.1.8; GPDH), an oligodendrocyte marker; CR16, whose sequence is not yet identified; and glial fibrillary acidic protein (GFAP), a marker of astroglial reactivity.	Corticosterone	91-105	cortistatin	Rattus norvegicus	107-111
2357595-2	1990	We have previously cloned hippocampal mRNAs that respond to the endogenous glucocorticoid, corticosterone (CORT): glycerol phosphate dehydrogenase (EC 1.1.1.8; GPDH), an oligodendrocyte marker; CR16, whose sequence is not yet identified; and glial fibrillary acidic protein (GFAP), a marker of astroglial reactivity.	Corticosterone	91-105	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	160-164
2357595-2	1990	We have previously cloned hippocampal mRNAs that respond to the endogenous glucocorticoid, corticosterone (CORT): glycerol phosphate dehydrogenase (EC 1.1.1.8; GPDH), an oligodendrocyte marker; CR16, whose sequence is not yet identified; and glial fibrillary acidic protein (GFAP), a marker of astroglial reactivity.	Corticosterone	91-105	WAS/WASL interacting protein family, member 3	Rattus norvegicus	194-198
2357595-2	1990	We have previously cloned hippocampal mRNAs that respond to the endogenous glucocorticoid, corticosterone (CORT): glycerol phosphate dehydrogenase (EC 1.1.1.8; GPDH), an oligodendrocyte marker; CR16, whose sequence is not yet identified; and glial fibrillary acidic protein (GFAP), a marker of astroglial reactivity.	Corticosterone	91-105	glial fibrillary acidic protein	Rattus norvegicus	242-273
2357595-2	1990	We have previously cloned hippocampal mRNAs that respond to the endogenous glucocorticoid, corticosterone (CORT): glycerol phosphate dehydrogenase (EC 1.1.1.8; GPDH), an oligodendrocyte marker; CR16, whose sequence is not yet identified; and glial fibrillary acidic protein (GFAP), a marker of astroglial reactivity.	Corticosterone	91-105	glial fibrillary acidic protein	Rattus norvegicus	275-279
2164646-6	1990	Direct or indirect stimulation of the CA1 pyramidal cells of the dorsal hippocampus appeared to have caused the increase in corticosterone secretion.	Corticosterone	124-138	carbonic anhydrase 1	Rattus norvegicus	38-41
2353583-0	1990	Long-lasting reduction of glucocorticoid receptor immunoreactivity in the hippocampal field CA1 but not in the dentate gyrus after neonatal treatment with corticosterone in the rat.	Corticosterone	155-169	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	26-49
2353583-0	1990	Long-lasting reduction of glucocorticoid receptor immunoreactivity in the hippocampal field CA1 but not in the dentate gyrus after neonatal treatment with corticosterone in the rat.	Corticosterone	155-169	carbonic anhydrase 1	Rattus norvegicus	92-95
2156674-0	1990	Rapid corticosterone inhibition of corticotropin-releasing hormone binding and adrenocorticotropin release by enriched populations of corticotropes: counteractions by arginine vasopressin and its second messengers.	Corticosterone	6-20	corticotropin releasing hormone	Homo sapiens	35-66
2156674-10	1990	Corticosterone pretreatment (100 nM) for 10 min caused a 50% reduction in the percentage of cells that bound CRH and in the levels of ACTH released in response to biotinylated CRH.	Corticosterone	0-14	corticotropin releasing hormone	Homo sapiens	109-112
2156674-10	1990	Corticosterone pretreatment (100 nM) for 10 min caused a 50% reduction in the percentage of cells that bound CRH and in the levels of ACTH released in response to biotinylated CRH.	Corticosterone	0-14	corticotropin releasing hormone	Homo sapiens	176-179
2156674-14	1990	We reasoned that this potentiation might promote a recovery in CRH binding to corticosterone-inhibited cells.	Corticosterone	78-92	corticotropin releasing hormone	Homo sapiens	63-66
2156674-17	1990	Furthermore, Bay K and 12-O-tetradecanoyl-phorbol-13-acetate pretreatment effectively blocked the fast feedback effects of corticosterone on CRH-mediated ACTH release.	Corticosterone	123-137	corticotropin releasing hormone	Homo sapiens	141-144
2162451-4	1990	In contrast, the (11-24)2Lys conjugate (10(-6)M) significantly decreased ACTH-induced stimulation of corticosterone and aldosterone (-63 and -62%, respectively).	Corticosterone	101-115	proopiomelanocortin	Homo sapiens	73-77
2162451-5	1990	The dimeric conjugate of the fragment ACTH(7-24), linked through the C-terminal ends, (7-24)2Lys (10(-6)M), was also completely devoid of effect on basal steroidogenesis but caused a marked decrease of ACTH-evoked corticosterone and aldosterone release (-72 and -80%, respectively).	Corticosterone	214-228	proopiomelanocortin	Homo sapiens	38-42
2316635-1	1990	We found microsomal corticosterone 6 beta-hydroxylase (6 beta-OHase) from cultured A6 kidney epithelial cells to be a cytochrome P-450 enzyme with both similarities to and differences from the rat liver steroid 6 beta-OHase P-450p.	Corticosterone	20-34	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	118-134
2157438-3	1990	The total cells from the inner portion of the adrenals metabolized [14C]7,12-dimethylbenz(a)anthracene at a rate of 4.04 pmol/min 10(6) cells and synthesized corticosterone in response to ACTH stimulation at a rate of 1.07 micrograms/hr/10(6) cells.	Corticosterone	158-172	proopiomelanocortin	Homo sapiens	188-192
2156641-0	1990	Interleukin-6 and ACTH act synergistically to stimulate the release of corticosterone from adrenal gland cells.	Corticosterone	71-85	interleukin 6	Rattus norvegicus	0-13
2156641-1	1990	We investigated whether interleukin-6 (IL-6) could cause the release of corticosterone by a direct interaction with the adrenal gland.	Corticosterone	72-86	interleukin 6	Rattus norvegicus	24-37
2156641-1	1990	We investigated whether interleukin-6 (IL-6) could cause the release of corticosterone by a direct interaction with the adrenal gland.	Corticosterone	72-86	interleukin 6	Rattus norvegicus	39-43
2156641-5	1990	Time course experiments demonstrated that IL-6 stimulated corticosterone release over a period of 24 h but not after 12 or 3 h. The stimulation of adrenal cells with different doses of ACTH1-24 and 40 U/ml of IL-6 showed a synergistic effect when IL-6 was combined with low concentrations of ACTH1-24 (2 and 20 pmol/l).	Corticosterone	58-72	interleukin 6	Rattus norvegicus	42-46
2156641-5	1990	Time course experiments demonstrated that IL-6 stimulated corticosterone release over a period of 24 h but not after 12 or 3 h. The stimulation of adrenal cells with different doses of ACTH1-24 and 40 U/ml of IL-6 showed a synergistic effect when IL-6 was combined with low concentrations of ACTH1-24 (2 and 20 pmol/l).	Corticosterone	58-72	interleukin 6	Rattus norvegicus	209-213
2156641-5	1990	Time course experiments demonstrated that IL-6 stimulated corticosterone release over a period of 24 h but not after 12 or 3 h. The stimulation of adrenal cells with different doses of ACTH1-24 and 40 U/ml of IL-6 showed a synergistic effect when IL-6 was combined with low concentrations of ACTH1-24 (2 and 20 pmol/l).	Corticosterone	58-72	interleukin 6	Rattus norvegicus	209-213
2155098-3	1990	A brief 22.5-min exposure to corticosterone strongly inhibited ACTH secretion evoked by arginine vasopressin (AVP), 48 mM KC1, and two types of combined stimuli, i.e. 41-residue CRF and AVP (0.05 and 0.5 nM, respectively; CRF/AVP), or ionomycin and phorbol-dibutyrate (200 and 10 nM, respectively; PdBu/IM).	Corticosterone	29-43	arginine vasopressin	Rattus norvegicus	97-108
2155098-3	1990	A brief 22.5-min exposure to corticosterone strongly inhibited ACTH secretion evoked by arginine vasopressin (AVP), 48 mM KC1, and two types of combined stimuli, i.e. 41-residue CRF and AVP (0.05 and 0.5 nM, respectively; CRF/AVP), or ionomycin and phorbol-dibutyrate (200 and 10 nM, respectively; PdBu/IM).	Corticosterone	29-43	arginine vasopressin	Rattus norvegicus	110-113
2155098-3	1990	A brief 22.5-min exposure to corticosterone strongly inhibited ACTH secretion evoked by arginine vasopressin (AVP), 48 mM KC1, and two types of combined stimuli, i.e. 41-residue CRF and AVP (0.05 and 0.5 nM, respectively; CRF/AVP), or ionomycin and phorbol-dibutyrate (200 and 10 nM, respectively; PdBu/IM).	Corticosterone	29-43	arginine vasopressin	Rattus norvegicus	186-189
2155098-3	1990	A brief 22.5-min exposure to corticosterone strongly inhibited ACTH secretion evoked by arginine vasopressin (AVP), 48 mM KC1, and two types of combined stimuli, i.e. 41-residue CRF and AVP (0.05 and 0.5 nM, respectively; CRF/AVP), or ionomycin and phorbol-dibutyrate (200 and 10 nM, respectively; PdBu/IM).	Corticosterone	29-43	arginine vasopressin	Rattus norvegicus	186-189
2361456-6	1990	Tactivin added at doses from 0.00064-2 micrograms/ml together with ACTH (1.6 microIU/ml) to isolated adrenal cells hindered the stimulatory influence of ACTH on the production of corticosterone by the adrenal cells.	Corticosterone	179-193	pro-opiomelanocortin-alpha	Mus musculus	67-71
2361456-6	1990	Tactivin added at doses from 0.00064-2 micrograms/ml together with ACTH (1.6 microIU/ml) to isolated adrenal cells hindered the stimulatory influence of ACTH on the production of corticosterone by the adrenal cells.	Corticosterone	179-193	pro-opiomelanocortin-alpha	Mus musculus	153-157
2361462-3	1990	Placement of rats into an unfamiliar cage (novel environment stress; NES), that elevated CS, NA and A, was used as a stressor.	Corticosterone	89-91	nestin	Rattus norvegicus	69-72
2361462-8	1990	A medium dose of CDP (9 mg/kg) attenuated the NES-induced CS and A elevations.	Corticosterone	58-60	nestin	Rattus norvegicus	46-49
2361462-9	1990	A high dose of CDP (27 mg/kg), that elevated basal CS release, prevented a further CS increase by NES and inhibited the NA and A response to NES.	Corticosterone	83-85	nestin	Rattus norvegicus	98-101
2157993-0	1990	Intracerebroventricular injection of platelet-activating factor induces secretion of adrenocorticotropin, beta-endorphin and corticosterone in conscious rats: a possible link between the immune and nervous systems.	Corticosterone	125-139	PCNA clamp associated factor	Rattus norvegicus	37-63
2157993-2	1990	PAF on adrenocorticotropic hormone (ACTH), beta-endorphin and corticosterone blood levels were examined in adult male rats.	Corticosterone	62-76	PCNA clamp associated factor	Rattus norvegicus	0-3
2155805-7	1990	In contrast, in vivo administration of PAF-acether caused a significant reduction of ACTH concentration in the anterior lobe of the pituitary and a marked decrease in the corticosterone level in plasma and adrenal glands.	Corticosterone	171-185	PCNA clamp associated factor	Rattus norvegicus	39-42
1689969-2	1990	In vivo challenge with acute ethanol or CRH administration or the stress of novel handling resulted in a more pronounced increase in serum corticosterone levels in LS mice compared with SS mice.	Corticosterone	139-153	corticotropin releasing hormone	Mus musculus	40-43
2309931-0	1990	Neuropeptide Y in the hypothalamus: effect on corticosterone and single-unit activity.	Corticosterone	46-60	neuropeptide Y	Rattus norvegicus	0-14
2174519-1	1990	Experimental evidence indicates that animals exposed to chronic stress demonstrate increased adrenocorticotropin (ACTH) and corticosterone (CORT) responses to novel stimuli (facilitation) but attenuated ACTH and CORT responses to the chronic stressor (adaptation).	Corticosterone	124-138	cortistatin	Rattus norvegicus	140-144
2305602-9	1990	Our results suggest that the maternal response of corticosteroid binding globulin to adrenalectomy depends on the pregnancy stage inasmuch as it may be influenced by a supply of corticosterone from the fetus during late pregnancy.	Corticosterone	178-192	serpin family A member 6	Rattus norvegicus	50-81
2239425-3	1990	Ligand specificity of mineralocorticoid receptors for either corticosterone or aldosterone seems to be determined by co-localized transcortin and the enzyme, 11 beta-hydroxysteroid dehydrogenase.	Corticosterone	61-75	serpin family A member 6	Homo sapiens	130-141
2239425-6	1990	These limbic mineralocorticoid receptor sites mediate tonic influences of corticosterone on brain processes.	Corticosterone	74-88	nuclear receptor subfamily 3 group C member 2	Homo sapiens	13-39
33971622-7	2021	We further found that 12-kDa mimecan fused protein increased the corticosterone secretion of adrenal cells in vivo and in vitro.	Corticosterone	65-79	osteoglycin	Homo sapiens	29-36
2309931-1	1990	The purpose of the present study was to determine whether neuropeptide Y (NPY) acts within the hypothalamic paraventricular nucleus (PVN) or the suprachiasmatic nucleus (SCN) to alter circulating levels of corticosterone and to evaluate the effects of NPY on the single-unit response of PVN and SCN neurons using the hypothalamic slice preparation.	Corticosterone	206-220	neuropeptide Y	Rattus norvegicus	58-72
2309931-1	1990	The purpose of the present study was to determine whether neuropeptide Y (NPY) acts within the hypothalamic paraventricular nucleus (PVN) or the suprachiasmatic nucleus (SCN) to alter circulating levels of corticosterone and to evaluate the effects of NPY on the single-unit response of PVN and SCN neurons using the hypothalamic slice preparation.	Corticosterone	206-220	neuropeptide Y	Rattus norvegicus	74-77
2309931-3	1990	NPY injected into the PVN 4 h after light onset resulted in corticosterone levels of 13.15 +/- 2.18 (SE) micrograms/dl within 1 h, which were significantly higher than the corticosterone levels of 4.08 +/- 1.78 micrograms/dl seen in rats receiving Sal injections.	Corticosterone	60-74	neuropeptide Y	Rattus norvegicus	0-3
2309931-9	1990	In summary, NPY alters the electrical activity of both SCN and PVN neurons but appears to act only within the PVN to influence circulating levels of corticosterone.	Corticosterone	149-163	neuropeptide Y	Rattus norvegicus	12-15
2153019-6	1990	Tumor necrosis factor alone, however, induced a significant increase in liver nitrogen content and diminished jejunal mucosa DNA and protein levels in comparison with the control and corticosterone groups.	Corticosterone	183-197	tumor necrosis factor-like	Rattus norvegicus	0-21
2159353-4	1990	On the background of ACTH (1.6 microIU/ml) taktivin (0.00064-0.4 microgram/ml) decreased corticosterone production to a basal level.	Corticosterone	89-103	pro-opiomelanocortin-alpha	Mus musculus	21-25
2159353-5	1990	When the cells were stimulated by ACTH (1600 microIU/ml) taktivin (0.000125-2 micrograms/ml) decreased corticosterone production to a marked degree.	Corticosterone	103-117	pro-opiomelanocortin-alpha	Mus musculus	34-38
2331433-12	1990	PGE2 increased CDP in the presence of Indo or Cort but PTH did not.	Corticosterone	46-50	cut-like homeobox 1	Rattus norvegicus	15-18
2209250-4	1990	Available evidence indicates that corticosterone can modulate dopamine transmission in the basal ganglia via glucocorticoid receptors within the nucleus accumbens and neostriatum, and via glucocorticoid receptor immunoreactivity in nigrostriatal and mesolimbic dopamine pathways.	Corticosterone	34-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	109-132
2152865-3	1990	IGF-I inhibited ACTH-, forskolin-, and (Bu)2cAMP-induced corticosterone production in a concentration-dependent manner.	Corticosterone	57-71	insulin-like growth factor 1	Rattus norvegicus	0-5
2344838-0	1990	Time-dependent effects of increased serum prolactin levels on corticosterone synthesis and secretion in male rats.	Corticosterone	62-76	prolactin	Rattus norvegicus	42-51
2174486-1	1990	Compared to younger rats, old rats exhibit prolonged elevations of plasma ACTH and corticosterone (CORT) in response to stress.	Corticosterone	83-97	cortistatin	Rattus norvegicus	99-103
2160651-2	1990	ACTH/MSH(4-10)-NH2, Ac-ACTH/MSH(4-10) and Ac-ACTH/MSH(4-10)-NH2 (10 microM to 1 mM) stimulated the aldosterone production of zona glomerulosa cells, whereas these peptides did not stimulate the corticosterone production of zona fasciculata cells, even at 1 mM concentration.	Corticosterone	194-208	proopiomelanocortin	Homo sapiens	0-4
2160651-3	1990	As ACTH/MSH(4-10) has been shown to have a steroidogenic effect on both types of adrenocortical cells, both charged chain termini seem to be essential for triggering of the corticosterone production of zona fasciculata cells, but for aldosterone production their presence appears not to be important.	Corticosterone	173-187	proopiomelanocortin	Homo sapiens	3-7
2112392-7	1990	An injection of 1 microgram of ovine CRH increased corticosterone after 0.5 h and elevated T3 and T4 after 2 h to the same extent in Dw and dw embryos.	Corticosterone	51-65	corticotropin releasing hormone	Gallus gallus	37-40
33941859-6	2021	Thus, CPEB3-KO neurons with elevated GR expression exhibited increased corticosterone-induced calcium influx and decreased mRNA and protein levels of brain-derived neurotrophic factor (Bdnf).	Corticosterone	71-85	cytoplasmic polyadenylation element binding protein 3	Mus musculus	6-11
33941859-6	2021	Thus, CPEB3-KO neurons with elevated GR expression exhibited increased corticosterone-induced calcium influx and decreased mRNA and protein levels of brain-derived neurotrophic factor (Bdnf).	Corticosterone	71-85	nuclear receptor subfamily 3, group C, member 1	Mus musculus	37-39
33971622-8	2021	Interestingly, compared to litter-mate mice, the diurnal rhythm of corticosterone secretion was disrupted under basal conditions, and the response to restraint stress was stronger in mimecan knockout mice.	Corticosterone	67-81	osteoglycin	Homo sapiens	183-190
33971622-9	2021	These findings suggest that mimecan stimulates corticosterone secretion in the adrenal tissues under basal conditions; however, the down-regulated expression of mimecan by increased ACTH secretion after stress in adrenal tissues might play a role in maintaining the homeostasis of an organism"s responses to stress.	Corticosterone	47-61	osteoglycin	Homo sapiens	28-35
33808441-8	2021	Thirty mg/kg of V1aR-antagonist increased the corticosterone levels.	Corticosterone	46-60	arginine vasopressin receptor 1A	Rattus norvegicus	16-20
33790733-4	2021	Immobilization stress-induced production of serum corticosterone was also completely inhibited by MyD88 deficiency.	Corticosterone	50-64	myeloid differentiation primary response gene 88	Mus musculus	98-103
33790733-8	2021	These results suggest that MyD88 deficiency attenuates depression-like behavior by regulating corticosterone and BDNF levels.	Corticosterone	94-108	myeloid differentiation primary response gene 88	Mus musculus	27-32
32890590-8	2020	Corticosterone levels were increased in the early phase after tumor induction at day 6 in both groups but returned to baseline levels at day 21 in the PrRP knockdown group.	Corticosterone	0-14	prolactin releasing hormone	Rattus norvegicus	151-155
32797129-9	2020	Furthermore, EEM and M 18:3 alleviated CORT-induced reduction in the positive expression rates of PCNA and Ki67 in the testicles of rats.	Corticosterone	39-43	proliferating cell nuclear antigen	Rattus norvegicus	98-102
32797129-10	2020	Besides, EEM and M 18:3 reduced the expression levels of Keap-1 and increased the expression levels of Nrf2, HO-1, gamma-GCS, and NQO1 in the testicles of CORT-induced rats.	Corticosterone	155-159	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	130-134
1656771-5	1991	Cytosolic glucocorticoid receptor numbers were similar in liver and brain of 4-wk-old lean and ob/ob mice is likely secondary to elevated plasma corticosterone concentrations in these older mice.	Corticosterone	145-159	nuclear receptor subfamily 3, group C, member 1	Mus musculus	10-33
33803097-11	2021	The ovoinhibitor protein was involved in response to mineralocorticoid and corticosterone biological processes whereas the vitellin membrane outer layer protein constituted the extracellular exosome, extracellular organelle, and membrane-bounded vesicle cellular components.	Corticosterone	75-89	serine peptidase inhibitor, Kazal type 5	Gallus gallus	4-16
29515805-7	2018	High humidity prior to blood collection reduced both baseline and stress-induced plasma corticosterone (CORT).	Corticosterone	88-102	CORT	Gallus gallus	104-108
26363495-9	2015	At both timepoints, overexpression of alpha-synuclein was linked to a hyperactive hypothalamic-pituitary-adrenal (HPA) axis regulation of corticosterone.	Corticosterone	138-152	synuclein alpha	Homo sapiens	38-53
8070360-1	1994	Centrally administered histamine (HA) stimulates the secretion of adenohypophysial POMC-derived peptides, which subsequently cause release of corticosterone.	Corticosterone	142-156	proopiomelanocortin	Homo sapiens	83-87
8070385-3	1994	11 beta-Hydroxysteroid dehydrogenase (11 beta HSD) catalyzes the interconversion of active corticosterone (B) to inactive 11-dehydrocorticosterone and protects the nonselective mineralocorticoid receptor (MR) from glucocorticoid excess.	Corticosterone	91-105	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	177-203
8070376-3	1994	An at least 100-fold higher concentration of cortisol (F), corticosterone (B), or dexamethasone was required to obtain half-maximum transactivation, indicating a functional preference of hMR for aldosterone over glucocorticoids.	Corticosterone	59-73	mannose receptor C-type 1	Homo sapiens	187-190
8070385-3	1994	11 beta-Hydroxysteroid dehydrogenase (11 beta HSD) catalyzes the interconversion of active corticosterone (B) to inactive 11-dehydrocorticosterone and protects the nonselective mineralocorticoid receptor (MR) from glucocorticoid excess.	Corticosterone	91-105	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	205-207
34836742-3	2022	These effects seem to be regulated by mechanisms involving Bdnf responses to noise trauma and circulating levels of corticosterone (CORT).	Corticosterone	116-130	brain derived neurotrophic factor	Mus musculus	59-63
34836742-3	2022	These effects seem to be regulated by mechanisms involving Bdnf responses to noise trauma and circulating levels of corticosterone (CORT).	Corticosterone	132-136	brain derived neurotrophic factor	Mus musculus	59-63
34798123-5	2022	With the administration of ketoconazole (300 mg/kg/day) for 7 days, Aadac knockout mice showed higher mortality (100%) than wild-type mice (42.9%), and they also showed significantly higher plasma alanine transaminase and lower corticosterone levels, thus representing liver injury and steroidogenesis inhibition, respectively.	Corticosterone	228-242	arylacetamide deacetylase	Mus musculus	68-73
34863999-2	2022	Because these stress-induced changes are driven, in part, by brain corticotropin-releasing factor and corticosterone, and because alterations in the activity of these molecules and the stress system are commonly associated with neuropsychiatric diseases like anxiety, depression, and schizophrenia, we hypothesized that amylin might mitigate behavioral states associated with stress.	Corticosterone	102-116	islet amyloid polypeptide	Rattus norvegicus	320-326
34672045-7	2022	Moreover, we show that the low alcohol preference of Cry1/2-/- mice concurs with high corticosterone and low levels of the orexin precursor prepro-orexin and that WT and Cry1/2-/- mice respond differently to alcohol withdrawal.	Corticosterone	86-100	cryptochrome 1 (photolyase-like)	Mus musculus	53-59
34798123-6	2022	It was suggested that a higher plasma ketoconazole concentration likely accounts for the inhibition of the synthesis of corticosterone, which has anti-inflammatory effects, in the adrenal gland in Aadac KO mice.	Corticosterone	120-134	arylacetamide deacetylase	Mus musculus	197-202
34785258-7	2022	Results showed enhanced catalase (CAT) and superoxide dismutase (SOD) activities, as well as an elevated formation of thiobarbituric acid reactive substances (TBARS), in the cerebral cortex of CORT-treated mice.	Corticosterone	193-197	catalase	Mus musculus	24-32
34793941-4	2022	Here, we studied how peripubertal stress (PPS) combined with differential corticosterone (CORT)-stress responsiveness (CSR) influences depressive-like behaviors and brain inflammatory markers in male rats in adulthood, and how these alterations relate to microglia activation and miR-342 expression.	Corticosterone	74-88	microRNA 342	Rattus norvegicus	280-287
34793941-4	2022	Here, we studied how peripubertal stress (PPS) combined with differential corticosterone (CORT)-stress responsiveness (CSR) influences depressive-like behaviors and brain inflammatory markers in male rats in adulthood, and how these alterations relate to microglia activation and miR-342 expression.	Corticosterone	90-94	microRNA 342	Rattus norvegicus	280-287
34767802-0	2022	Glucocorticoid receptor mediates corticosterone-thyroid hormone synergy essential for metamorphosis in Xenopus tropicalis tadpoles.	Corticosterone	33-47	nuclear receptor subfamily 3 group C member 1	Xenopus tropicalis	0-23
34808367-5	2022	Injection of 11beta-HSD2 overexpression lentivirus into the bone marrow cavity could partially alleviate the accumulation of bone local active corticosterone and bone loss induced by PDE.	Corticosterone	143-157	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	13-24
34808367-7	2022	Overexpression of 11beta-HSD2 partially alleviated the inhibitory effect of corticosterone.	Corticosterone	76-90	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	18-29
34843801-9	2022	Thus, fasting suppressed testicular steroidogenesis by affecting the enzyme activity of 3beta-HSD in the testes and drastically reduced T and increased CORT synthesis.	Corticosterone	152-156	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	88-97
34970787-6	2022	In contrast, GFAP-Tk female rats have increased corticosterone secretion at nadir, a heightened, yet delayed, response to an acute stress stimulus, accompanied by neuronal hypertrophy in the basal lateral amygdala and increased expression of the glucocorticoid receptors in the ventral DG.	Corticosterone	48-62	glial fibrillary acidic protein	Rattus norvegicus	13-17
34948340-12	2021	Differences revealed between MCAO-KM and MCAO-LM suggest that corticosterone and interleukin-1beta release as well as hippocampal accumulation is more expressed in MCAO-KM rats, predisposing them to corticosterone-dependent distant neuroinflammatory hippocampal damage.	Corticosterone	199-213	interleukin 1 beta	Rattus norvegicus	81-98
34952453-0	2022	Interaction between corticosterone and PER2 in regulating emotional behaviors in the rat.	Corticosterone	20-34	period circadian regulator 2	Rattus norvegicus	39-43
34948014-2	2021	We studied GR haploinsufficient (GR+/-) Sprague Dawley rats which, on a standard diet, showed significantly increased plasma aldosterone and corticosterone levels and an adrenocortex hyperplasia accompanied by a normal systolic blood pressure.	Corticosterone	141-155	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	11-13
34948014-2	2021	We studied GR haploinsufficient (GR+/-) Sprague Dawley rats which, on a standard diet, showed significantly increased plasma aldosterone and corticosterone levels and an adrenocortex hyperplasia accompanied by a normal systolic blood pressure.	Corticosterone	141-155	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	33-35
34536123-4	2021	PSD-93 overexpression in CRH neurons in the PVN induced depression-like behaviors in mice, accompanied by increased serum corticosterone level.	Corticosterone	122-136	discs large MAGUK scaffold protein 2	Mus musculus	0-6
34536123-4	2021	PSD-93 overexpression in CRH neurons in the PVN induced depression-like behaviors in mice, accompanied by increased serum corticosterone level.	Corticosterone	122-136	corticotropin releasing hormone	Mus musculus	25-28
34500039-2	2021	As a result, CORT injection induced depressive-like behaviors of mice in behavioral tests, aggravated the serum CORT, adrenocorticotropic hormone, and corticotropin-releasing hormone levels, and conspicuously elevated the phosphorylations of NF-kappaB in the hippocampus and frontal cortex, and down-regulated the expression levels of Nrf2.	Corticosterone	13-17	corticotropin releasing hormone	Mus musculus	151-182
26408049-6	2015	In contrast, sodium channels Nav1.7 and Nav1.8 were up-regulated in L4-L5 but not L6-S2 DRGs in stressed rats, which was reproduced in control DRGs treated with corticosterone in vitro.	Corticosterone	161-175	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	29-35
26408049-6	2015	In contrast, sodium channels Nav1.7 and Nav1.8 were up-regulated in L4-L5 but not L6-S2 DRGs in stressed rats, which was reproduced in control DRGs treated with corticosterone in vitro.	Corticosterone	161-175	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	40-46
34767802-7	2022	To directly examine the role of GR in TH signaling, we co-treated tadpoles with TH and CORT and found that the TH response gene, thrb, was induced significantly beyond the level induced by TH alone in wild-type tadpoles but not in GR knockout tadpoles or wild-type tadpoles treated with RU486.	Corticosterone	87-91	nuclear receptor subfamily 3 group C member 1	Xenopus tropicalis	32-34
34767802-7	2022	To directly examine the role of GR in TH signaling, we co-treated tadpoles with TH and CORT and found that the TH response gene, thrb, was induced significantly beyond the level induced by TH alone in wild-type tadpoles but not in GR knockout tadpoles or wild-type tadpoles treated with RU486.	Corticosterone	87-91	thyroid hormone receptor, beta	Xenopus tropicalis	129-133
34905510-6	2022	Embryonic not postnatal osteocalcin also governs adrenal growth, adrenal steroidogenesis, blood pressure, electrolyte equilibrium and the rise of circulating corticosterone during the acute stress response in adult offspring.	Corticosterone	158-172	bone gamma-carboxyglutamate protein 2	Mus musculus	24-35
34959395-0	2021	CRF-R1 Antagonist Treatment Exacerbates Circadian Corticosterone Secretion under Chronic Stress, but Preserves HPA Feedback Sensitivity.	Corticosterone	50-64	corticotropin releasing hormone receptor 1	Mus musculus	0-6
34872591-1	2021	BACKGROUND: Glucocorticoid receptor (GR) mediated corticosterone-induced fatty liver syndrome (FLS) in the chicken by transactivation of Fat mass and obesity associated gene (FTO), leading to demethylation of N6-methyladenosine (m6A) and post-transcriptional activation of lipogenic genes.	Corticosterone	50-64	nuclear receptor subfamily 3 group C member 1	Gallus gallus	12-35
34872591-1	2021	BACKGROUND: Glucocorticoid receptor (GR) mediated corticosterone-induced fatty liver syndrome (FLS) in the chicken by transactivation of Fat mass and obesity associated gene (FTO), leading to demethylation of N6-methyladenosine (m6A) and post-transcriptional activation of lipogenic genes.	Corticosterone	50-64	nuclear receptor subfamily 3 group C member 1	Gallus gallus	37-39
34872591-1	2021	BACKGROUND: Glucocorticoid receptor (GR) mediated corticosterone-induced fatty liver syndrome (FLS) in the chicken by transactivation of Fat mass and obesity associated gene (FTO), leading to demethylation of N6-methyladenosine (m6A) and post-transcriptional activation of lipogenic genes.	Corticosterone	50-64	FTO, alpha-ketoglutarate dependent dioxygenase	Gallus gallus	175-178
34500039-2	2021	As a result, CORT injection induced depressive-like behaviors of mice in behavioral tests, aggravated the serum CORT, adrenocorticotropic hormone, and corticotropin-releasing hormone levels, and conspicuously elevated the phosphorylations of NF-kappaB in the hippocampus and frontal cortex, and down-regulated the expression levels of Nrf2.	Corticosterone	13-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	242-251
34500039-2	2021	As a result, CORT injection induced depressive-like behaviors of mice in behavioral tests, aggravated the serum CORT, adrenocorticotropic hormone, and corticotropin-releasing hormone levels, and conspicuously elevated the phosphorylations of NF-kappaB in the hippocampus and frontal cortex, and down-regulated the expression levels of Nrf2.	Corticosterone	13-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	335-339
34500039-3	2021	Furthermore, CORT exposure dramatically augmented the levels of inflammatory factors (IL-1beta, TNF-alpha, iNOS, NO) and lipid peroxidation product MDA, and attenuated the levels of antioxidants including GSH, GST, SOD, and HO-1 in the hippocampus and frontal cortex.	Corticosterone	13-17	interleukin 1 alpha	Mus musculus	86-94
34500039-3	2021	Furthermore, CORT exposure dramatically augmented the levels of inflammatory factors (IL-1beta, TNF-alpha, iNOS, NO) and lipid peroxidation product MDA, and attenuated the levels of antioxidants including GSH, GST, SOD, and HO-1 in the hippocampus and frontal cortex.	Corticosterone	13-17	tumor necrosis factor	Mus musculus	96-105
34500039-3	2021	Furthermore, CORT exposure dramatically augmented the levels of inflammatory factors (IL-1beta, TNF-alpha, iNOS, NO) and lipid peroxidation product MDA, and attenuated the levels of antioxidants including GSH, GST, SOD, and HO-1 in the hippocampus and frontal cortex.	Corticosterone	13-17	nitric oxide synthase 2, inducible	Mus musculus	107-111
34500039-3	2021	Furthermore, CORT exposure dramatically augmented the levels of inflammatory factors (IL-1beta, TNF-alpha, iNOS, NO) and lipid peroxidation product MDA, and attenuated the levels of antioxidants including GSH, GST, SOD, and HO-1 in the hippocampus and frontal cortex.	Corticosterone	13-17	heme oxygenase 1	Mus musculus	224-228
34618891-9	2021	Additionally, DREADDs inhibition of MePD Ucn3 neurons blocked TMT and restraint stress-induced inhibition of LH pulses and corticosterone release.	Corticosterone	123-137	urocortin 3	Mus musculus	41-45
34343356-9	2021	Plasma corticosterone and brain glutamate level was decreased and GABA level were increased significantly evident with GAD activation in AKBA treated animals, further confirmed with decreased GR expression improves architecture of prefrontal cortex region.	Corticosterone	7-21	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	192-194
34618891-10	2021	These results demonstrate for the first time that Ucn3 neurons in the MePD mediate psychosocial stress-induced suppression of the GnRH pulse generator and corticosterone secretion.	Corticosterone	155-169	urocortin 3	Mus musculus	50-54
34643545-8	2021	Females had higher expression of CYP11A1 and StAR; and increased CYP11A1 activity (increased pregnenolone/ corticosterone levels) but did not differ in CYP11B2 expression or activity (aldosterone/ levels).	Corticosterone	107-121	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	65-72
34947858-9	2021	Male mice given chronic corticosterone (CORT) that were housed in the same cage as gently handled animals (GH) exhibited increased immobility, whereas GH females housed with CORT females demonstrated the opposite effect.	Corticosterone	24-38	growth hormone	Mus musculus	107-109
34601003-2	2021	In the first 24h after the stress event, a daily variation of blood corticosterone increased, and testosterone decreased; the testosterone/corticosterone were lowest at the end of the stress session overlapping with inhibition of Leydig cells" steroidogenesis-related genes (Nr3c1/GR, Hsd3b1/2, Star, Cyp17a1) and changed circadian activity of the clock genes (the increased Bmal1/BMAL1 and Per1/2/PER1 and decreased Cry1 and Rev-erba).	Corticosterone	139-153	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	275-280
34601003-2	2021	In the first 24h after the stress event, a daily variation of blood corticosterone increased, and testosterone decreased; the testosterone/corticosterone were lowest at the end of the stress session overlapping with inhibition of Leydig cells" steroidogenesis-related genes (Nr3c1/GR, Hsd3b1/2, Star, Cyp17a1) and changed circadian activity of the clock genes (the increased Bmal1/BMAL1 and Per1/2/PER1 and decreased Cry1 and Rev-erba).	Corticosterone	139-153	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	281-283
34601003-2	2021	In the first 24h after the stress event, a daily variation of blood corticosterone increased, and testosterone decreased; the testosterone/corticosterone were lowest at the end of the stress session overlapping with inhibition of Leydig cells" steroidogenesis-related genes (Nr3c1/GR, Hsd3b1/2, Star, Cyp17a1) and changed circadian activity of the clock genes (the increased Bmal1/BMAL1 and Per1/2/PER1 and decreased Cry1 and Rev-erba).	Corticosterone	139-153	steroidogenic acute regulatory protein	Rattus norvegicus	295-299
34601003-2	2021	In the first 24h after the stress event, a daily variation of blood corticosterone increased, and testosterone decreased; the testosterone/corticosterone were lowest at the end of the stress session overlapping with inhibition of Leydig cells" steroidogenesis-related genes (Nr3c1/GR, Hsd3b1/2, Star, Cyp17a1) and changed circadian activity of the clock genes (the increased Bmal1/BMAL1 and Per1/2/PER1 and decreased Cry1 and Rev-erba).	Corticosterone	139-153	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	375-380
34601003-2	2021	In the first 24h after the stress event, a daily variation of blood corticosterone increased, and testosterone decreased; the testosterone/corticosterone were lowest at the end of the stress session overlapping with inhibition of Leydig cells" steroidogenesis-related genes (Nr3c1/GR, Hsd3b1/2, Star, Cyp17a1) and changed circadian activity of the clock genes (the increased Bmal1/BMAL1 and Per1/2/PER1 and decreased Cry1 and Rev-erba).	Corticosterone	139-153	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	381-386
34601003-2	2021	In the first 24h after the stress event, a daily variation of blood corticosterone increased, and testosterone decreased; the testosterone/corticosterone were lowest at the end of the stress session overlapping with inhibition of Leydig cells" steroidogenesis-related genes (Nr3c1/GR, Hsd3b1/2, Star, Cyp17a1) and changed circadian activity of the clock genes (the increased Bmal1/BMAL1 and Per1/2/PER1 and decreased Cry1 and Rev-erba).	Corticosterone	139-153	period circadian regulator 1	Rattus norvegicus	391-397
34601003-2	2021	In the first 24h after the stress event, a daily variation of blood corticosterone increased, and testosterone decreased; the testosterone/corticosterone were lowest at the end of the stress session overlapping with inhibition of Leydig cells" steroidogenesis-related genes (Nr3c1/GR, Hsd3b1/2, Star, Cyp17a1) and changed circadian activity of the clock genes (the increased Bmal1/BMAL1 and Per1/2/PER1 and decreased Cry1 and Rev-erba).	Corticosterone	139-153	cryptochrome circadian regulator 1	Rattus norvegicus	417-421
34848858-3	2022	Chronic oral corticosterone (CORT) induced increased anxiety- and depression-like behavior in wild-type male mice and male mice heterozygous for the gene coding for brain-derived neurotrophic factor Val66Met, a variant associated with genetic susceptibility to stress.	Corticosterone	13-27	brain derived neurotrophic factor	Mus musculus	165-198
34848858-3	2022	Chronic oral corticosterone (CORT) induced increased anxiety- and depression-like behavior in wild-type male mice and male mice heterozygous for the gene coding for brain-derived neurotrophic factor Val66Met, a variant associated with genetic susceptibility to stress.	Corticosterone	29-33	brain derived neurotrophic factor	Mus musculus	165-198
34474339-10	2021	LBP treatment reduced offspring"s plasma corticosterone level and improved their body weight, changed the emotional function, increased the diversity of gut microbiota.	Corticosterone	41-55	lipopolysaccharide binding protein	Rattus norvegicus	0-3
34764725-14	2021	Further, it restored the plasma levels of corticosterone to within the normal range, accompanied by an increase in adrenocorticotropic hormone.	Corticosterone	42-56	pro-opiomelanocortin-alpha	Mus musculus	115-142
34490902-3	2021	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1; EC 1.1.1.146), encoded by Hsd11b1, is a key regulator of the local concentration of CORT/cortisol.	Corticosterone	141-145	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-42
34490902-3	2021	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1; EC 1.1.1.146), encoded by Hsd11b1, is a key regulator of the local concentration of CORT/cortisol.	Corticosterone	141-145	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	44-55
34490902-3	2021	11beta-Hydroxysteroid dehydrogenase type 1 (11beta-HSD1; EC 1.1.1.146), encoded by Hsd11b1, is a key regulator of the local concentration of CORT/cortisol.	Corticosterone	141-145	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	83-90
34490902-14	2021	Our observation suggests that Hsd11b1 expression in the developing neocortex is affected by systemic CORT levels.	Corticosterone	101-105	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	30-37
34500039-0	2021	Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-kappaB and Nrf2.	Corticosterone	37-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	210-219
34500039-0	2021	Antidepressant effect of catalpol on corticosterone-induced depressive-like behavior involves the inhibition of HPA axis hyperactivity, central inflammation and oxidative damage probably via dual regulation of NF-kappaB and Nrf2.	Corticosterone	37-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	224-228
34500039-2	2021	As a result, CORT injection induced depressive-like behaviors of mice in behavioral tests, aggravated the serum CORT, adrenocorticotropic hormone, and corticotropin-releasing hormone levels, and conspicuously elevated the phosphorylations of NF-kappaB in the hippocampus and frontal cortex, and down-regulated the expression levels of Nrf2.	Corticosterone	13-17	pro-opiomelanocortin-alpha	Mus musculus	118-145
34814007-2	2022	Within key metabolic tissues, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone to the active glucocorticoid, cortisol (11-dehydrocorticosterone and corticosterone in rodents respectively), and thus amplifies local glucocorticoid action.	Corticosterone	175-189	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	30-72
34814007-2	2022	Within key metabolic tissues, 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) converts cortisone to the active glucocorticoid, cortisol (11-dehydrocorticosterone and corticosterone in rodents respectively), and thus amplifies local glucocorticoid action.	Corticosterone	175-189	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	74-85
34867228-6	2021	We observed a strikingly rapid change in the expression of established GR target genes (t = 30 min) only in the SPS group on exogenous corticosterone injection.	Corticosterone	135-149	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	71-73
34828008-7	2021	UCP3 and COX6A1 were diversely and significantly expressed in the muscle, liver, and heart of the CORT-fed chicken.	Corticosterone	98-102	uncoupling protein 3	Gallus gallus	0-4
34828008-7	2021	UCP3 and COX6A1 were diversely and significantly expressed in the muscle, liver, and heart of the CORT-fed chicken.	Corticosterone	98-102	cytochrome c oxidase subunit 6A1	Gallus gallus	9-15
34828008-8	2021	Significant expression of SAAL1 and CRP in the liver and hypothalamus of the CORT-fed chickens was observed at week 4 and 6.	Corticosterone	77-81	protein SAAL1	Gallus gallus	26-31
34828008-8	2021	Significant expression of SAAL1 and CRP in the liver and hypothalamus of the CORT-fed chickens was observed at week 4 and 6.	Corticosterone	77-81	C-reactive protein like 1	Gallus gallus	36-39
34830120-4	2021	Crabp1 knockout (CKO) mice exhibit reduced anxiety-like behaviors accompanied by a lowered stress induced-corticosterone level.	Corticosterone	106-120	cellular retinoic acid binding protein I	Mus musculus	0-6
34830120-6	2021	Gene expression studies show reduced FKBP5 expression in CKO mice; this would decrease the suppression of glucocorticoid receptor (GR) signaling thereby enhancing their feedback inhibition, consistent with their dampened corticosterone level and anxiety-like behaviors upon stress induction.	Corticosterone	221-235	FK506 binding protein 5	Mus musculus	37-42
34767585-6	2021	Furthermore, we investigated whether mice showed alterations in plasma levels of stress-associated signal molecules (corticosterone, cytokines, hormones, receptors), and found that Kpna1 knockout significantly altered levels of corticosterone and LIX (CXCL5).	Corticosterone	228-242	karyopherin (importin) alpha 1	Mus musculus	181-186
34867772-4	2021	In our investigation of hormone co-variation, we find a strong correlation between prolactin and corticosterone across sampling stages and similarities in earlier (early to mid-incubation) compared to later (late incubation to nestling d9) sampling stages in males and females.	Corticosterone	97-111	prolactin	Columba livia	83-92
34822681-5	2021	Levels of the high-specificity and -affinity corticosteroid-binding globulin protein increased in the lungs of both strains proportional to the rise in corticosterone levels following O3 exposure.	Corticosterone	152-166	serpin family A member 6	Rattus norvegicus	45-76
34419429-10	2021	Finally, we treated primary amygdala neurons with corticosterone to mimic psychological stress; corticosterone-induced upregulation of GluA1 was prevented by BDNF and mTOR antagonists.	Corticosterone	50-64	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	135-140
34697420-6	2021	Meanwhile, serum corticosterone, the expression and histone 3 lysine 14 acetylation (H3K14ac) of testicular insulin-like growth factor 1 (IGF1) were significantly decreased.	Corticosterone	17-31	insulin-like growth factor 1	Rattus norvegicus	108-136
34697420-6	2021	Meanwhile, serum corticosterone, the expression and histone 3 lysine 14 acetylation (H3K14ac) of testicular insulin-like growth factor 1 (IGF1) were significantly decreased.	Corticosterone	17-31	insulin-like growth factor 1	Rattus norvegicus	138-142
34689156-9	2021	The stress-miRNA-CCND1 signaling regulation of the tumor cell proliferation was further validated in 4T1 cells treated with corticosterone in vitro.	Corticosterone	124-138	cyclin D1	Mus musculus	17-22
34454011-10	2021	In conclusion, PEE could induce adrenal dysplasia in offspring with sex differences and intergenerational genetic effects, and the adrenal insufficiency in male offspring was related to the induction of low functional genetic programming of P450scc by intrauterine high corticosterone through the GR/SF1/HDAC1 pathway.	Corticosterone	270-284	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	241-248
34454011-10	2021	In conclusion, PEE could induce adrenal dysplasia in offspring with sex differences and intergenerational genetic effects, and the adrenal insufficiency in male offspring was related to the induction of low functional genetic programming of P450scc by intrauterine high corticosterone through the GR/SF1/HDAC1 pathway.	Corticosterone	270-284	G-rich RNA sequence binding factor 1	Rattus norvegicus	297-303
34454011-10	2021	In conclusion, PEE could induce adrenal dysplasia in offspring with sex differences and intergenerational genetic effects, and the adrenal insufficiency in male offspring was related to the induction of low functional genetic programming of P450scc by intrauterine high corticosterone through the GR/SF1/HDAC1 pathway.	Corticosterone	270-284	histone deacetylase 1	Rattus norvegicus	304-309
34087399-4	2021	Our previous results indicated that pretreatment with Rg1 significantly improved Cx43-gap junction in corticosterone (CORT)-treated astrocytes.	Corticosterone	102-116	gap junction protein, alpha 1	Rattus norvegicus	81-85
34087399-4	2021	Our previous results indicated that pretreatment with Rg1 significantly improved Cx43-gap junction in corticosterone (CORT)-treated astrocytes.	Corticosterone	118-122	gap junction protein, alpha 1	Rattus norvegicus	81-85
34087399-9	2021	RESULTS: Pretreatment with Rg1 could reverse CORT-induced downregulation of Cx43 biosynthesis, acceleration of Cx43 degradation, and upregulation of two Cx43 degradation pathways in primary astrocytes.	Corticosterone	45-49	gap junction protein, alpha 1	Rattus norvegicus	76-80
34087399-9	2021	RESULTS: Pretreatment with Rg1 could reverse CORT-induced downregulation of Cx43 biosynthesis, acceleration of Cx43 degradation, and upregulation of two Cx43 degradation pathways in primary astrocytes.	Corticosterone	45-49	gap junction protein, alpha 1	Rattus norvegicus	111-115
34087399-9	2021	RESULTS: Pretreatment with Rg1 could reverse CORT-induced downregulation of Cx43 biosynthesis, acceleration of Cx43 degradation, and upregulation of two Cx43 degradation pathways in primary astrocytes.	Corticosterone	45-49	gap junction protein, alpha 1	Rattus norvegicus	153-157
34419429-10	2021	Finally, we treated primary amygdala neurons with corticosterone to mimic psychological stress; corticosterone-induced upregulation of GluA1 was prevented by BDNF and mTOR antagonists.	Corticosterone	96-110	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	135-140
34419429-10	2021	Finally, we treated primary amygdala neurons with corticosterone to mimic psychological stress; corticosterone-induced upregulation of GluA1 was prevented by BDNF and mTOR antagonists.	Corticosterone	96-110	brain derived neurotrophic factor	Mus musculus	158-162
34419429-10	2021	Finally, we treated primary amygdala neurons with corticosterone to mimic psychological stress; corticosterone-induced upregulation of GluA1 was prevented by BDNF and mTOR antagonists.	Corticosterone	96-110	mechanistic target of rapamycin kinase	Mus musculus	167-171
34599158-5	2021	Loss of the clock gene Bmal1 in CRH neurons results in arrhythmic PVNCRH calcium activity and dramatically reduces the amplitude and precision of daily corticosterone release.	Corticosterone	152-166	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	23-28
34599158-5	2021	Loss of the clock gene Bmal1 in CRH neurons results in arrhythmic PVNCRH calcium activity and dramatically reduces the amplitude and precision of daily corticosterone release.	Corticosterone	152-166	corticotropin releasing hormone	Homo sapiens	32-35
34464518-8	2021	Lean (L)+CS offspring had higher serum corticosterone concentration and reduced liver peroxisome proliferator-activated receptor gamma expression compared with L+NB.	Corticosterone	39-53	citrate synthase	Rattus norvegicus	9-11
34265317-8	2021	Furthermore, CORT injections decreased the expression of hippocampal synapse-related proteins, cell density and dendritic spine density in the hippocampus, accompanied by increased protein expression in the MAPK signaling pathway and decreased expression of the GR.	Corticosterone	13-17	nuclear receptor subfamily 3, group C, member 1	Mus musculus	262-264
34573048-8	2021	In human retinal pigment epithelium (ARPE-19) cells, the PRDX6 expression level decreases after being treated with stress hormone corticosterone.	Corticosterone	130-144	peroxiredoxin 6	Homo sapiens	57-62
34483146-10	2022	Rapid ACTH injection resulted in elevations in the deoxycorticosterone, corticosterone, aldosterone, and 17-hydroxypregnenolone levels, but not in the cortisol level.	Corticosterone	72-86	proopiomelanocortin	Homo sapiens	6-10
34082199-7	2021	The histone 3 lysine 27 acetylation (H3K27ac) level of the insulin-like growth factor 1 (IGF1) promoter region and its expression were decreased in the ovary, which was due to exposure to high levels of fetal blood corticosterone, and the H3K27ac level of IGF1 and its expression shifted to increase after birth with a decrease in serum corticosterone levels.	Corticosterone	215-229	insulin like growth factor 1	Homo sapiens	59-87
34082199-7	2021	The histone 3 lysine 27 acetylation (H3K27ac) level of the insulin-like growth factor 1 (IGF1) promoter region and its expression were decreased in the ovary, which was due to exposure to high levels of fetal blood corticosterone, and the H3K27ac level of IGF1 and its expression shifted to increase after birth with a decrease in serum corticosterone levels.	Corticosterone	215-229	insulin-like growth factor 1	Rattus norvegicus	89-93
34082199-7	2021	The histone 3 lysine 27 acetylation (H3K27ac) level of the insulin-like growth factor 1 (IGF1) promoter region and its expression were decreased in the ovary, which was due to exposure to high levels of fetal blood corticosterone, and the H3K27ac level of IGF1 and its expression shifted to increase after birth with a decrease in serum corticosterone levels.	Corticosterone	337-351	insulin like growth factor 1	Homo sapiens	59-87
34082199-7	2021	The histone 3 lysine 27 acetylation (H3K27ac) level of the insulin-like growth factor 1 (IGF1) promoter region and its expression were decreased in the ovary, which was due to exposure to high levels of fetal blood corticosterone, and the H3K27ac level of IGF1 and its expression shifted to increase after birth with a decrease in serum corticosterone levels.	Corticosterone	337-351	insulin-like growth factor 1	Rattus norvegicus	89-93
34082199-7	2021	The histone 3 lysine 27 acetylation (H3K27ac) level of the insulin-like growth factor 1 (IGF1) promoter region and its expression were decreased in the ovary, which was due to exposure to high levels of fetal blood corticosterone, and the H3K27ac level of IGF1 and its expression shifted to increase after birth with a decrease in serum corticosterone levels.	Corticosterone	337-351	insulin-like growth factor 1	Rattus norvegicus	256-260
34166790-7	2021	Co-administration of the glucocorticoid receptor antagonist RU 486 (10 ng) prevented the corticosterone effect, indicating that glucocorticoids enhance the extinction of stimulus-response memory via activation of the glucocorticoid receptor.	Corticosterone	89-103	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	25-48
34166790-7	2021	Co-administration of the glucocorticoid receptor antagonist RU 486 (10 ng) prevented the corticosterone effect, indicating that glucocorticoids enhance the extinction of stimulus-response memory via activation of the glucocorticoid receptor.	Corticosterone	89-103	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	217-240
34166170-3	2021	The glucocorticoid hormone corticosterone (CORT) can alter the transcription and activation of proteins, including homologues of snake venom components such as snake venom metalloproteinases (SVMPs) and phospholipase A2 (PLA2).	Corticosterone	27-41	phospholipase A2 group IB	Homo sapiens	203-219
34166170-3	2021	The glucocorticoid hormone corticosterone (CORT) can alter the transcription and activation of proteins, including homologues of snake venom components such as snake venom metalloproteinases (SVMPs) and phospholipase A2 (PLA2).	Corticosterone	27-41	phospholipase A2 group IB	Homo sapiens	221-225
34166170-3	2021	The glucocorticoid hormone corticosterone (CORT) can alter the transcription and activation of proteins, including homologues of snake venom components such as snake venom metalloproteinases (SVMPs) and phospholipase A2 (PLA2).	Corticosterone	43-47	phospholipase A2 group IB	Homo sapiens	203-219
34166170-3	2021	The glucocorticoid hormone corticosterone (CORT) can alter the transcription and activation of proteins, including homologues of snake venom components such as snake venom metalloproteinases (SVMPs) and phospholipase A2 (PLA2).	Corticosterone	43-47	phospholipase A2 group IB	Homo sapiens	221-225
34512285-7	2021	Results: The study showed that musk inhalation significantly reduced (p < 0.001) corticosterone level, immobility time, inflammatory cytokines, and oxidative stress markers in CUMS-exposed mice compared to the untreated CUMS group.	Corticosterone	81-95	muscle, skeletal, receptor tyrosine kinase	Mus musculus	31-35
34444624-5	2021	The resultant novel BRET-based on the ERalpha dimerization assay was used to identify the binding affinity of 17beta-estradiol (E2), 17alpha-estradiol, corticosterone, diethylhexyl phthalate, bisphenol A, and 4-nonylphenol with ERalpha by measuring the corresponding BRET signals.	Corticosterone	152-166	estrogen receptor 1	Homo sapiens	38-45
34444624-5	2021	The resultant novel BRET-based on the ERalpha dimerization assay was used to identify the binding affinity of 17beta-estradiol (E2), 17alpha-estradiol, corticosterone, diethylhexyl phthalate, bisphenol A, and 4-nonylphenol with ERalpha by measuring the corresponding BRET signals.	Corticosterone	152-166	estrogen receptor 1	Homo sapiens	228-235
34444624-6	2021	Consequently, the BRET signals from five chemicals except corticosterone showed a dose-dependent sigmoidal curve for ERalpha, and these chemicals were suggested as positive chemicals for ERalpha.	Corticosterone	58-72	estrogen receptor 1	Homo sapiens	117-124
34444624-6	2021	Consequently, the BRET signals from five chemicals except corticosterone showed a dose-dependent sigmoidal curve for ERalpha, and these chemicals were suggested as positive chemicals for ERalpha.	Corticosterone	58-72	estrogen receptor 1	Homo sapiens	187-194
34444624-7	2021	In contrast, corticosterone, which induced a BRET signal comparable to that of the vehicle control, was suggested as a negative chemical for ERalpha.	Corticosterone	13-27	estrogen receptor 1	Homo sapiens	141-148
34339164-6	2021	The evaluation of transcription factors indicated that almost 50% of miRNA genes sensitive to corticosterone in both sexes was under glucocorticoid receptor regulation.	Corticosterone	94-108	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	133-156
34404890-3	2021	Corticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic-pituitary-adrenal (HPA) axis and stress-evoked corticosterone secretion.	Corticosterone	156-170	corticotropin releasing hormone	Homo sapiens	0-31
34404890-3	2021	Corticotropin-releasing hormone (CRH) neurons are the primary neural population controlling the hypothalamic-pituitary-adrenal (HPA) axis and stress-evoked corticosterone secretion.	Corticosterone	156-170	corticotropin releasing hormone	Homo sapiens	33-36
34375333-0	2021	Corticosterone pattern-dependent glucocorticoid receptor binding and transcriptional regulation within the liver.	Corticosterone	0-14	nuclear receptor subfamily 3 group C member 1	Homo sapiens	33-56
34375333-2	2021	Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynamic pattern of glucocorticoid receptor (GR) binding at ~3,000 genomic sites in liver at the pulse peak, subsequently not found during the pulse nadir.	Corticosterone	35-49	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	116-139
34375333-2	2021	Here we demonstrate that pulsatile corticosterone replacement in adrenalectomised rats induces a dynamic pattern of glucocorticoid receptor (GR) binding at ~3,000 genomic sites in liver at the pulse peak, subsequently not found during the pulse nadir.	Corticosterone	35-49	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	141-143
34368959-0	2022	Thioredoxin interacting protein drives astrocytic glucose hypometabolism in corticosterone-induced depressive state.	Corticosterone	76-90	thioredoxin interacting protein	Rattus norvegicus	0-31
34368959-6	2022	Interestingly, thioredoxin interacting protein (TXNIP), a glucose metabolism sensor and controller, was found to be overexpressed in corticosterone-stimulated astrocytes in vivo and in vitro.	Corticosterone	133-147	thioredoxin interacting protein	Rattus norvegicus	15-46
34368959-6	2022	Interestingly, thioredoxin interacting protein (TXNIP), a glucose metabolism sensor and controller, was found to be overexpressed in corticosterone-stimulated astrocytes in vivo and in vitro.	Corticosterone	133-147	thioredoxin interacting protein	Rattus norvegicus	48-53
34368959-9	2022	Conversely, TXNIP siRNA facilitated GLUT1 PM translocation to recover glucose hypometabolism in corticosterone-exposed cultured astrocytes.	Corticosterone	96-110	solute carrier family 2 member 1	Rattus norvegicus	36-41
34261039-7	2021	In contrast, corticosterone was only associated with higher insulin sensitivity (Matsuda index; 0.22 (0.03, 0.41)), but this was not independent of BMI.	Corticosterone	13-27	insulin	Homo sapiens	60-67
34381366-5	2021	Low doses of CORT (0.3 and 3 mg/kg) significantly increased MR activation, upregulated Akt/CREB/Bad phosphorylation and Bcl-2 concentration, reduced the number of apoptotic neural cells, and subsequently improved rat spatial memory.	Corticosterone	13-17	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	60-62
34381366-5	2021	Low doses of CORT (0.3 and 3 mg/kg) significantly increased MR activation, upregulated Akt/CREB/Bad phosphorylation and Bcl-2 concentration, reduced the number of apoptotic neural cells, and subsequently improved rat spatial memory.	Corticosterone	13-17	AKT serine/threonine kinase 1	Rattus norvegicus	87-90
34381366-5	2021	Low doses of CORT (0.3 and 3 mg/kg) significantly increased MR activation, upregulated Akt/CREB/Bad phosphorylation and Bcl-2 concentration, reduced the number of apoptotic neural cells, and subsequently improved rat spatial memory.	Corticosterone	13-17	cAMP responsive element binding protein 1	Rattus norvegicus	91-95
34381366-5	2021	Low doses of CORT (0.3 and 3 mg/kg) significantly increased MR activation, upregulated Akt/CREB/Bad phosphorylation and Bcl-2 concentration, reduced the number of apoptotic neural cells, and subsequently improved rat spatial memory.	Corticosterone	13-17	BCL2, apoptosis regulator	Rattus norvegicus	120-125
34381366-6	2021	In contrast, a high dose of CORT (30 mg/kg) exerted the opposite effects by overactivating GR, upregulating P53/Bax levels, and inhibiting Erk/CREB activity.	Corticosterone	28-32	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	91-93
34381366-6	2021	In contrast, a high dose of CORT (30 mg/kg) exerted the opposite effects by overactivating GR, upregulating P53/Bax levels, and inhibiting Erk/CREB activity.	Corticosterone	28-32	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	108-111
34381366-6	2021	In contrast, a high dose of CORT (30 mg/kg) exerted the opposite effects by overactivating GR, upregulating P53/Bax levels, and inhibiting Erk/CREB activity.	Corticosterone	28-32	BCL2 associated X, apoptosis regulator	Rattus norvegicus	112-115
34381366-6	2021	In contrast, a high dose of CORT (30 mg/kg) exerted the opposite effects by overactivating GR, upregulating P53/Bax levels, and inhibiting Erk/CREB activity.	Corticosterone	28-32	Eph receptor B1	Rattus norvegicus	139-142
34381366-6	2021	In contrast, a high dose of CORT (30 mg/kg) exerted the opposite effects by overactivating GR, upregulating P53/Bax levels, and inhibiting Erk/CREB activity.	Corticosterone	28-32	cAMP responsive element binding protein 1	Rattus norvegicus	143-147
34238184-14	2022	In contrast, corticosterone (an OCT3 inhibitor) only significantly inhibited the cellular uptake of 1000 ng/mL fluoxetine (P <.05).	Corticosterone	13-27	solute carrier family 22 member 3	Homo sapiens	32-36
34187898-4	2021	A blocking antibody to the GDNF-family receptor alpha-like receptor completely prevented the corticosterone response to GDF15 administration.	Corticosterone	93-107	growth differentiation factor 15	Rattus norvegicus	120-125
34215821-3	2021	Therefore, the aim of this study was to examine the metabolic effects of chronic treatment with the GC corticosterone (Cort, 75 mug/ml in drinking water) in mice lacking the glucocorticoid receptor (GR) on AgRP neurons.	Corticosterone	103-117	agouti related neuropeptide	Mus musculus	206-210
34215821-3	2021	Therefore, the aim of this study was to examine the metabolic effects of chronic treatment with the GC corticosterone (Cort, 75 mug/ml in drinking water) in mice lacking the glucocorticoid receptor (GR) on AgRP neurons.	Corticosterone	119-123	agouti related neuropeptide	Mus musculus	206-210
34215821-4	2021	Female AgRP-GR KO mice had delayed onset of Cort-induced hyperphagia.	Corticosterone	44-48	agouti related neuropeptide	Mus musculus	7-11
34215821-4	2021	Female AgRP-GR KO mice had delayed onset of Cort-induced hyperphagia.	Corticosterone	44-48	nuclear receptor subfamily 3, group C, member 1	Mus musculus	12-14
34215821-7	2021	Additionally, Cort treatment led to hyperinsulinaemia, but compared to controls, Cort-treated AgRP-GR KO mice had both lower fasting insulin levels and lower insulin levels during a glucose tolerance test.	Corticosterone	81-85	agouti related neuropeptide	Mus musculus	94-98
34215821-7	2021	Additionally, Cort treatment led to hyperinsulinaemia, but compared to controls, Cort-treated AgRP-GR KO mice had both lower fasting insulin levels and lower insulin levels during a glucose tolerance test.	Corticosterone	81-85	nuclear receptor subfamily 3, group C, member 1	Mus musculus	99-101
34103895-11	2021	Conclusion: Our study shows that moderate inhibition of 11beta-HSD1 by BVT.2733 reduces FFAs and corticosterone synthesis in fatty tissues, thereby attenuates the delivery of corticosterone and FFAs to the liver.	Corticosterone	97-111	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	56-67
34103895-11	2021	Conclusion: Our study shows that moderate inhibition of 11beta-HSD1 by BVT.2733 reduces FFAs and corticosterone synthesis in fatty tissues, thereby attenuates the delivery of corticosterone and FFAs to the liver.	Corticosterone	175-189	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	56-67
34122166-10	2021	Moreover, corticosterone (100-400 muM) treatment for 24 h increased LC3-II/LC3-I protein ratio, increased Beclin1 and ULK1 protein expression levels, and decreased p62, PI3K, p-PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein expression levels.	Corticosterone	10-24	beclin 1	Rattus norvegicus	106-113
34122166-10	2021	Moreover, corticosterone (100-400 muM) treatment for 24 h increased LC3-II/LC3-I protein ratio, increased Beclin1 and ULK1 protein expression levels, and decreased p62, PI3K, p-PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein expression levels.	Corticosterone	10-24	unc-51 like autophagy activating kinase 1	Rattus norvegicus	118-122
34122166-10	2021	Moreover, corticosterone (100-400 muM) treatment for 24 h increased LC3-II/LC3-I protein ratio, increased Beclin1 and ULK1 protein expression levels, and decreased p62, PI3K, p-PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein expression levels.	Corticosterone	10-24	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	164-167
34122166-10	2021	Moreover, corticosterone (100-400 muM) treatment for 24 h increased LC3-II/LC3-I protein ratio, increased Beclin1 and ULK1 protein expression levels, and decreased p62, PI3K, p-PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein expression levels.	Corticosterone	10-24	AKT serine/threonine kinase 1	Rattus norvegicus	185-188
34122166-10	2021	Moreover, corticosterone (100-400 muM) treatment for 24 h increased LC3-II/LC3-I protein ratio, increased Beclin1 and ULK1 protein expression levels, and decreased p62, PI3K, p-PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein expression levels.	Corticosterone	10-24	mechanistic target of rapamycin kinase	Rattus norvegicus	192-196
34122166-10	2021	Moreover, corticosterone (100-400 muM) treatment for 24 h increased LC3-II/LC3-I protein ratio, increased Beclin1 and ULK1 protein expression levels, and decreased p62, PI3K, p-PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein expression levels.	Corticosterone	10-24	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	213-218
34122166-11	2021	Notably, SNS-containing serum reversed corticosterone-induced reduction of neuronal viability, and increased p62, PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein and mRNA expression levels.	Corticosterone	39-53	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	109-112
34122166-11	2021	Notably, SNS-containing serum reversed corticosterone-induced reduction of neuronal viability, and increased p62, PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein and mRNA expression levels.	Corticosterone	39-53	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
34122166-11	2021	Notably, SNS-containing serum reversed corticosterone-induced reduction of neuronal viability, and increased p62, PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein and mRNA expression levels.	Corticosterone	39-53	mechanistic target of rapamycin kinase	Rattus norvegicus	129-133
34122166-11	2021	Notably, SNS-containing serum reversed corticosterone-induced reduction of neuronal viability, and increased p62, PI3K, p-Akt, p-mTOR, p-p70S6, and p-4ebp1 protein and mRNA expression levels.	Corticosterone	39-53	eukaryotic translation initiation factor 4E binding protein 1	Rattus norvegicus	150-155
34072239-7	2021	Aged 11beta-HSD1 knockout mice (n = 11), 11beta-HSD1 inhibitor (INHI)-treated aged wild type (WT) mice (n = 5) and young WT mice (n = 10) exhibited reduced SC corticosterone level.	Corticosterone	159-173	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	5-16
34072239-7	2021	Aged 11beta-HSD1 knockout mice (n = 11), 11beta-HSD1 inhibitor (INHI)-treated aged wild type (WT) mice (n = 5) and young WT mice (n = 10) exhibited reduced SC corticosterone level.	Corticosterone	159-173	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	41-52
34188184-4	2021	In a longitudinal experimental design using freely behaving pre-plaque McGill-R-Thy1-APP male rats, three injections of corticosterone or the glucocorticoid methylprednisolone profoundly disrupted long-term potentiation induced by strong conditioning stimulation for at least 2 months.	Corticosterone	120-134	Thy-1 cell surface antigen	Rattus norvegicus	80-84
34188184-7	2021	Evidence for the involvement of pro-inflammatory mechanisms was provided by the ability of the selective the NOD-leucine rich repeat and pyrin containing protein 3 (NLRP3) inflammasome inhibitor Mcc950 to reverse the synaptic plasticity deficit in corticosterone-treated transgenic animals.	Corticosterone	248-262	NLR family, pyrin domain containing 3	Rattus norvegicus	165-170
34568711-0	2021	11betaHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone.	Corticosterone	98-112	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	0-10
34568711-0	2021	11betaHSD2 Efficacy in Preventing Transcriptional Activation of the Mineralocorticoid Receptor by Corticosterone.	Corticosterone	98-112	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	68-94
34568711-1	2021	Affinity of the mineralocorticoid receptor (MR) is similar for aldosterone and the glucocorticoids (GC) cortisol and corticosterone, which circulate at concentrations far exceeding those of aldosterone.	Corticosterone	117-131	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	16-42
34568711-1	2021	Affinity of the mineralocorticoid receptor (MR) is similar for aldosterone and the glucocorticoids (GC) cortisol and corticosterone, which circulate at concentrations far exceeding those of aldosterone.	Corticosterone	117-131	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	44-46
34568711-4	2021	The aim of this work was to address doubts that low levels of expression of 11betaHSD2 in aldosterone target tissues suffice to prevent the initiation of gene transcription by the MR activated by physiological concentrations of corticosterone.	Corticosterone	228-242	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	76-86
34568711-8	2021	The 50% maximal MR activation for the reporter gene stimulation by corticosterone rose with increasing 11betaHSD2 expression, shifting the steroid dose-response curve for corticosterone-induced MR transactivation to the right.	Corticosterone	67-81	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	103-113
34568711-8	2021	The 50% maximal MR activation for the reporter gene stimulation by corticosterone rose with increasing 11betaHSD2 expression, shifting the steroid dose-response curve for corticosterone-induced MR transactivation to the right.	Corticosterone	171-185	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	103-113
34280473-7	2021	The spatiotemporal response to CORT + CPO sequentially activated phosphoproteins (p-ERK1/2, p-MEK1/2, p-JNK) involved in mitogen-activated protein kinase (MAPK) signaling.	Corticosterone	31-35	mitogen-activated protein kinase 3	Mus musculus	84-90
34280473-7	2021	The spatiotemporal response to CORT + CPO sequentially activated phosphoproteins (p-ERK1/2, p-MEK1/2, p-JNK) involved in mitogen-activated protein kinase (MAPK) signaling.	Corticosterone	31-35	mitogen-activated protein kinase kinase 1	Mus musculus	94-100
34280473-7	2021	The spatiotemporal response to CORT + CPO sequentially activated phosphoproteins (p-ERK1/2, p-MEK1/2, p-JNK) involved in mitogen-activated protein kinase (MAPK) signaling.	Corticosterone	31-35	mitogen-activated protein kinase 8	Mus musculus	104-107
34589667-9	2021	Increased circulating CORT levels are probably associated with the activation of the hypothalamus-pituitary-interrenal axis by the LPS and the endocrine actions of IL-6.	Corticosterone	22-26	interleukin 6	Homo sapiens	164-168
34307952-8	2021	Specifically, CORT + CPO exposure was found to sequentially activate several phosphoproteins involved in mitogen activated protein kinase signaling (p-MEK1/2, p-ERK1/2, and p-JNK).	Corticosterone	14-18	mitogen-activated protein kinase kinase 1	Mus musculus	151-157
34307952-8	2021	Specifically, CORT + CPO exposure was found to sequentially activate several phosphoproteins involved in mitogen activated protein kinase signaling (p-MEK1/2, p-ERK1/2, and p-JNK).	Corticosterone	14-18	mitogen-activated protein kinase 3	Mus musculus	161-167
34307952-8	2021	Specifically, CORT + CPO exposure was found to sequentially activate several phosphoproteins involved in mitogen activated protein kinase signaling (p-MEK1/2, p-ERK1/2, and p-JNK).	Corticosterone	14-18	mitogen-activated protein kinase 8	Mus musculus	175-178
34386327-2	2021	In this study, we aimed to investigate the protective effect of VMY-2-95, the new selective antagonist of alpha4beta2 nicotinic acetylcholine receptor (nAChR) on corticosterone (CORT) injured mice and cellular models.	Corticosterone	162-176	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	152-157
34386327-2	2021	In this study, we aimed to investigate the protective effect of VMY-2-95, the new selective antagonist of alpha4beta2 nicotinic acetylcholine receptor (nAChR) on corticosterone (CORT) injured mice and cellular models.	Corticosterone	178-182	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	152-157
34189788-5	2021	The release of VP from the SCN signals the near arrival of the resting phase in rodents and prepares their physiology accordingly by down-modulating corticosterone secretion, the reproductive cycle and locomotor activity.	Corticosterone	149-163	arginine vasopressin	Homo sapiens	15-17
34060474-2	2021	In male mice, however, blocking ghrelin receptor (GHSR) signalling increased the weight gain and adiposity induced by chronic corticosterone (CORT), rather than attenuating them.	Corticosterone	126-140	growth hormone secretagogue receptor	Mus musculus	32-48
34060474-2	2021	In male mice, however, blocking ghrelin receptor (GHSR) signalling increased the weight gain and adiposity induced by chronic corticosterone (CORT), rather than attenuating them.	Corticosterone	126-140	growth hormone secretagogue receptor	Mus musculus	50-54
34060474-2	2021	In male mice, however, blocking ghrelin receptor (GHSR) signalling increased the weight gain and adiposity induced by chronic corticosterone (CORT), rather than attenuating them.	Corticosterone	142-146	growth hormone secretagogue receptor	Mus musculus	32-48
34060474-2	2021	In male mice, however, blocking ghrelin receptor (GHSR) signalling increased the weight gain and adiposity induced by chronic corticosterone (CORT), rather than attenuating them.	Corticosterone	142-146	growth hormone secretagogue receptor	Mus musculus	50-54
34220460-6	2021	Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-alpha, pro-inflammatory cytokines.	Corticosterone	38-52	interleukin 12b	Mus musculus	218-241
34220460-6	2021	Reserpine-induced increases in plasma corticosterone concentrations were attenuated by the administration of FX and its components, which were also found to decrease the reserpine-induced enhancement of mRNA levels of interleukin (IL)-12 p40, IL-6, and tumor necrosis factor (TNF)-alpha, pro-inflammatory cytokines.	Corticosterone	38-52	tumor necrosis factor	Mus musculus	253-286
34765515-8	2021	Hippocampal cell survival, the number of hippocampal new-born immature neurons, hippocampal and accumbal dendritic spine density and mRNA levels for neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) were decreased in CORT-treated mice without KIT treatment.	Corticosterone	247-251	glial cell line derived neurotrophic factor	Mus musculus	178-221
34765515-8	2021	Hippocampal cell survival, the number of hippocampal new-born immature neurons, hippocampal and accumbal dendritic spine density and mRNA levels for neurotrophic factors such as glial cell line-derived neurotrophic factor (GDNF) were decreased in CORT-treated mice without KIT treatment.	Corticosterone	247-251	glial cell line derived neurotrophic factor	Mus musculus	223-227
34765515-9	2021	KIT prevented CORT-induced depression-like behavior, spatial memory impairment, and decreases in hippocampal cell survival, the number of hippocampal new-born immature neurons, accumbal dendritic spine density and GDNF mRNA.	Corticosterone	14-18	glial cell line derived neurotrophic factor	Mus musculus	214-218
34068684-4	2021	The aim of the current translational study was to mimic a severe stress condition by exposing female CD-1 mouse dams to abnormal levels of corticosterone (80 microg/mL) in the drinking water either during the last week of pregnancy (PreCORT) or the first one of lactation (PostCORT), compared to an Animal Facility Rearing (AFR) control group.	Corticosterone	139-153	CD1 antigen complex	Mus musculus	101-105
34401204-6	2021	Fetal corticosterone exposure was measured by placental Abca1, Hsd11beta1, Hsd11beta2, and brain Nr3c1 (GR); Pomc expression measured by RT-qPCR.	Corticosterone	6-20	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	56-61
34401204-6	2021	Fetal corticosterone exposure was measured by placental Abca1, Hsd11beta1, Hsd11beta2, and brain Nr3c1 (GR); Pomc expression measured by RT-qPCR.	Corticosterone	6-20	nuclear receptor subfamily 3, group C, member 1	Mus musculus	97-102
34401204-6	2021	Fetal corticosterone exposure was measured by placental Abca1, Hsd11beta1, Hsd11beta2, and brain Nr3c1 (GR); Pomc expression measured by RT-qPCR.	Corticosterone	6-20	nuclear receptor subfamily 3, group C, member 1	Mus musculus	104-106
34401204-6	2021	Fetal corticosterone exposure was measured by placental Abca1, Hsd11beta1, Hsd11beta2, and brain Nr3c1 (GR); Pomc expression measured by RT-qPCR.	Corticosterone	6-20	pro-opiomelanocortin-alpha	Mus musculus	109-113
35461829-12	2022	LBN rats showed significantly dampened HPA axis responsivity, but epileptic rats showed greater corticosterone responses to CRH administration (all p < 0.05).	Corticosterone	96-110	corticotropin releasing hormone	Rattus norvegicus	124-127
34104992-4	2021	In this review we describe studies that demonstrate OCT3 expression and corticosterone-sensitive monoamine transport in the brain and present evidence supporting the hypothesis that corticosterone exerts rapid, nongenomic actions on glia and neurons, ultimately modulating physiology and behavior, by inhibiting OCT3-mediated monoamine clearance.	Corticosterone	182-196	OCTN3	Homo sapiens	312-316
35577112-0	2022	Corticosterone triggers anti-proliferative and apoptotic effects, and downregulates the ACVR1-SMAD1-ID3 cascade in chicken ovarian prehierarchical, but not preovulatory granulosa cells.	Corticosterone	0-14	serine/threonine-protein kinase receptor	Gallus gallus	88-93
35577112-0	2022	Corticosterone triggers anti-proliferative and apoptotic effects, and downregulates the ACVR1-SMAD1-ID3 cascade in chicken ovarian prehierarchical, but not preovulatory granulosa cells.	Corticosterone	0-14	SMAD family member 1	Gallus gallus	94-99
35577112-0	2022	Corticosterone triggers anti-proliferative and apoptotic effects, and downregulates the ACVR1-SMAD1-ID3 cascade in chicken ovarian prehierarchical, but not preovulatory granulosa cells.	Corticosterone	0-14	inhibitor of DNA binding 3, HLH protein	Gallus gallus	100-103
35577112-7	2022	After 24 h of treatment, INHBB, FST, FMOD, NOG, ACVR1, SMAD1 and ID3 were the genes that responded consistently with corticosterone-induced proliferative and apoptotic events in all granulosa cells detected.	Corticosterone	117-131	inhibin beta B subunit	Gallus gallus	25-30
35577112-7	2022	After 24 h of treatment, INHBB, FST, FMOD, NOG, ACVR1, SMAD1 and ID3 were the genes that responded consistently with corticosterone-induced proliferative and apoptotic events in all granulosa cells detected.	Corticosterone	117-131	fibromodulin	Gallus gallus	37-41
35577112-7	2022	After 24 h of treatment, INHBB, FST, FMOD, NOG, ACVR1, SMAD1 and ID3 were the genes that responded consistently with corticosterone-induced proliferative and apoptotic events in all granulosa cells detected.	Corticosterone	117-131	noggin	Gallus gallus	43-46
35577112-7	2022	After 24 h of treatment, INHBB, FST, FMOD, NOG, ACVR1, SMAD1 and ID3 were the genes that responded consistently with corticosterone-induced proliferative and apoptotic events in all granulosa cells detected.	Corticosterone	117-131	serine/threonine-protein kinase receptor	Gallus gallus	48-53
35577112-7	2022	After 24 h of treatment, INHBB, FST, FMOD, NOG, ACVR1, SMAD1 and ID3 were the genes that responded consistently with corticosterone-induced proliferative and apoptotic events in all granulosa cells detected.	Corticosterone	117-131	SMAD family member 1	Gallus gallus	55-60
35577112-7	2022	After 24 h of treatment, INHBB, FST, FMOD, NOG, ACVR1, SMAD1 and ID3 were the genes that responded consistently with corticosterone-induced proliferative and apoptotic events in all granulosa cells detected.	Corticosterone	117-131	inhibitor of DNA binding 3, HLH protein	Gallus gallus	65-68
35577112-8	2022	However, only ACVR1, SMAD1 and ID3 could initiate coincident expression patterns after being treated for 8 h, suggesting their significance in corticosterone-mediated actions.	Corticosterone	143-157	serine/threonine-protein kinase receptor	Gallus gallus	14-19
35577112-8	2022	However, only ACVR1, SMAD1 and ID3 could initiate coincident expression patterns after being treated for 8 h, suggesting their significance in corticosterone-mediated actions.	Corticosterone	143-157	SMAD family member 1	Gallus gallus	21-26
35577112-8	2022	However, only ACVR1, SMAD1 and ID3 could initiate coincident expression patterns after being treated for 8 h, suggesting their significance in corticosterone-mediated actions.	Corticosterone	143-157	inhibitor of DNA binding 3, HLH protein	Gallus gallus	31-34
35577112-9	2022	Collectively, these findings indicate that corticosterone can inhibit proliferation and cause apoptosis in chicken ovarian prehierarchical, but not preovulatory granulosa cells, through impeding ACVR1-SMAD1-ID3 signaling presumptively.	Corticosterone	43-57	serine/threonine-protein kinase receptor	Gallus gallus	195-200
35577112-9	2022	Collectively, these findings indicate that corticosterone can inhibit proliferation and cause apoptosis in chicken ovarian prehierarchical, but not preovulatory granulosa cells, through impeding ACVR1-SMAD1-ID3 signaling presumptively.	Corticosterone	43-57	SMAD family member 1	Gallus gallus	201-206
35577112-9	2022	Collectively, these findings indicate that corticosterone can inhibit proliferation and cause apoptosis in chicken ovarian prehierarchical, but not preovulatory granulosa cells, through impeding ACVR1-SMAD1-ID3 signaling presumptively.	Corticosterone	43-57	inhibitor of DNA binding 3, HLH protein	Gallus gallus	207-210
35487119-5	2022	Plasma corticosterone concentration was significantly (P < 0.05) elevated in betaine-treated fetuses, together with increased adrenal expression of melanocortin 2 receptor and steroidogenic acute regulatory protein.	Corticosterone	7-21	melanocortin 2 receptor	Gallus gallus	148-171
35622158-5	2022	rRF desynchronized the rhythms of plasma insulin and corticosterone.	Corticosterone	53-67	mitochondrial ribosome recycling factor	Rattus norvegicus	0-3
35331847-10	2022	We have also provided new data for the DAT-KO rat regarding the effects of slowing DA diffusion with dextran and blocking organic cation transporter 3 with corticosterone.	Corticosterone	156-170	solute carrier family 22 member 3	Rattus norvegicus	122-150
35417747-10	2022	In addition, SMT partly attenuated the poly I:C- and R848-induced increase in plasma corticosterone concentration, suggesting that corticosterone release induced by these virus analogues may be partly mediated by iNOS.	Corticosterone	85-99	nitric oxide synthase 2	Gallus gallus	213-217
35417747-10	2022	In addition, SMT partly attenuated the poly I:C- and R848-induced increase in plasma corticosterone concentration, suggesting that corticosterone release induced by these virus analogues may be partly mediated by iNOS.	Corticosterone	131-145	nitric oxide synthase 2	Gallus gallus	213-217
35339573-1	2022	The 11beta hydroxysteroid dehydrogenase type-1 (11betaHSD-1) is a predominant 11beta-reductase regenerating bioactive glucocorticoids (cortisol, corticosterone) from inactive 11-keto forms (cortisone, dehydrocorticosterone), expressed mainly in the brain, liver and adipose tissue.	Corticosterone	145-159	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	4-46
35339573-1	2022	The 11beta hydroxysteroid dehydrogenase type-1 (11betaHSD-1) is a predominant 11beta-reductase regenerating bioactive glucocorticoids (cortisol, corticosterone) from inactive 11-keto forms (cortisone, dehydrocorticosterone), expressed mainly in the brain, liver and adipose tissue.	Corticosterone	145-159	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	48-59
35398506-10	2022	Higher plasma corticosterone (CORT) was found in GDX males compared to GDX-DHT and sham males following restraint stress, with a negative correlation between PVN CRFR1+ neurons and corticosterone levels 30- and 90-minutes following restraint.	Corticosterone	14-28	corticotropin releasing hormone receptor 1	Mus musculus	162-167
35398506-10	2022	Higher plasma corticosterone (CORT) was found in GDX males compared to GDX-DHT and sham males following restraint stress, with a negative correlation between PVN CRFR1+ neurons and corticosterone levels 30- and 90-minutes following restraint.	Corticosterone	30-34	corticotropin releasing hormone receptor 1	Mus musculus	162-167
35588619-0	2022	Intrauterine programming of cartilaginous 11beta-HSD2 induced by corticosterone and caffeine mediated susceptibility to adult osteoarthritis.	Corticosterone	65-79	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	42-53
35588619-5	2022	The expression of 11beta-HSD2, aggrecan and Col2a1 were all decreased by corticosterone in the fetal chondrocytes, while overexpression of 11beta-HSD2 could partially alleviate the decrease of matrix synthesis induced by corticosterone in vitro.	Corticosterone	73-87	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	18-29
35588619-5	2022	The expression of 11beta-HSD2, aggrecan and Col2a1 were all decreased by corticosterone in the fetal chondrocytes, while overexpression of 11beta-HSD2 could partially alleviate the decrease of matrix synthesis induced by corticosterone in vitro.	Corticosterone	73-87	collagen type II alpha 1 chain	Rattus norvegicus	44-50
35588619-5	2022	The expression of 11beta-HSD2, aggrecan and Col2a1 were all decreased by corticosterone in the fetal chondrocytes, while overexpression of 11beta-HSD2 could partially alleviate the decrease of matrix synthesis induced by corticosterone in vitro.	Corticosterone	221-235	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	18-29
35588619-5	2022	The expression of 11beta-HSD2, aggrecan and Col2a1 were all decreased by corticosterone in the fetal chondrocytes, while overexpression of 11beta-HSD2 could partially alleviate the decrease of matrix synthesis induced by corticosterone in vitro.	Corticosterone	221-235	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	139-150
35218705-6	2022	Moreover, FMN reduced the serum corticosterone levels, upregulated the protein expression levels of the glucocorticoid receptor (GR), and brain-derived neurotrophic factor (BDNF) in the hippocampus, protected against the CORT-induced neuronal impairment, and promoted the neurogenesis in the hippocampus.	Corticosterone	221-225	nuclear receptor subfamily 3, group C, member 1	Mus musculus	129-131
35628305-6	2022	Neurochemically, the expressions of GR, FK506-binding proteins 4 and 5 (FKBP4 and FKBP5), and early growth response-1 (Egr-1) were assessed in the hippocampus, medial prefrontal cortex (mPFC), amygdala, and hypothalamus, together with the level of plasma corticosterone.	Corticosterone	255-269	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	36-38
35628305-6	2022	Neurochemically, the expressions of GR, FK506-binding proteins 4 and 5 (FKBP4 and FKBP5), and early growth response-1 (Egr-1) were assessed in the hippocampus, medial prefrontal cortex (mPFC), amygdala, and hypothalamus, together with the level of plasma corticosterone.	Corticosterone	255-269	FKBP prolyl isomerase 4	Rattus norvegicus	40-70
35628305-6	2022	Neurochemically, the expressions of GR, FK506-binding proteins 4 and 5 (FKBP4 and FKBP5), and early growth response-1 (Egr-1) were assessed in the hippocampus, medial prefrontal cortex (mPFC), amygdala, and hypothalamus, together with the level of plasma corticosterone.	Corticosterone	255-269	FKBP prolyl isomerase 4	Rattus norvegicus	72-77
35628305-6	2022	Neurochemically, the expressions of GR, FK506-binding proteins 4 and 5 (FKBP4 and FKBP5), and early growth response-1 (Egr-1) were assessed in the hippocampus, medial prefrontal cortex (mPFC), amygdala, and hypothalamus, together with the level of plasma corticosterone.	Corticosterone	255-269	FKBP prolyl isomerase 5	Rattus norvegicus	82-87
35628305-6	2022	Neurochemically, the expressions of GR, FK506-binding proteins 4 and 5 (FKBP4 and FKBP5), and early growth response-1 (Egr-1) were assessed in the hippocampus, medial prefrontal cortex (mPFC), amygdala, and hypothalamus, together with the level of plasma corticosterone.	Corticosterone	255-269	early growth response 1	Rattus norvegicus	94-117
35628305-6	2022	Neurochemically, the expressions of GR, FK506-binding proteins 4 and 5 (FKBP4 and FKBP5), and early growth response-1 (Egr-1) were assessed in the hippocampus, medial prefrontal cortex (mPFC), amygdala, and hypothalamus, together with the level of plasma corticosterone.	Corticosterone	255-269	early growth response 1	Rattus norvegicus	119-124
35562616-9	2022	Moreover, pretreatment of FGF2 elevated neuroligin 1 expression and trafficking of GluR1/2 into the postsynaptic compartment of mice exposed to prenatal corticosterone, improving spatial memory and depression/anxiety-like behaviors.	Corticosterone	153-167	fibroblast growth factor 2	Mus musculus	26-30
35562616-9	2022	Moreover, pretreatment of FGF2 elevated neuroligin 1 expression and trafficking of GluR1/2 into the postsynaptic compartment of mice exposed to prenatal corticosterone, improving spatial memory and depression/anxiety-like behaviors.	Corticosterone	153-167	neuroligin 1	Mus musculus	40-52
35562616-9	2022	Moreover, pretreatment of FGF2 elevated neuroligin 1 expression and trafficking of GluR1/2 into the postsynaptic compartment of mice exposed to prenatal corticosterone, improving spatial memory and depression/anxiety-like behaviors.	Corticosterone	153-167	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	83-90
35569374-8	2022	Consistent with in vivo results, co-exposure of corticosterone and AlNPs aggravated NLRP3-mediated pyroptosis and cathepsin B expression in HAPI cells.	Corticosterone	48-62	NLR family, pyrin domain containing 3	Rattus norvegicus	84-89
35569374-8	2022	Consistent with in vivo results, co-exposure of corticosterone and AlNPs aggravated NLRP3-mediated pyroptosis and cathepsin B expression in HAPI cells.	Corticosterone	48-62	cathepsin B	Rattus norvegicus	114-125
35571739-4	2022	Methods: A BCRD mouse model was induced by injecting 4T1 cells and corticosterone (COR).	Corticosterone	67-81	distribution of corticosterone in adrenal cortex cells	Mus musculus	83-86
35077967-6	2022	Of these, (10)-gingerol, angelicin, corticosterone, eupatilin, etofenprox, oxadixyl, and tretinoin were identified as novel AhR agonists.	Corticosterone	36-50	aryl hydrocarbon receptor	Homo sapiens	124-127
35094500-8	2022	Decreased levels of endogenous GR ligand corticosterone and lower expression of 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1), a metabolic enzyme that controls corticosterone availability, were found in livers of Vps15 mutants.	Corticosterone	166-180	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	80-117
35094500-8	2022	Decreased levels of endogenous GR ligand corticosterone and lower expression of 11beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1), a metabolic enzyme that controls corticosterone availability, were found in livers of Vps15 mutants.	Corticosterone	166-180	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	119-130
35510321-8	2022	Corticosterone-treated mice had significantly higher body weight (p <= 0.05) and BAT mass (p <= 0.05), increased adipocyte area (p <= 0.05), were insulin resistant (p <= 0.05), and significantly elevated expressions of uncoupling protein 1 (UCP-1) in BAT (p <= 0.05) while mitochondrial content remained unchanged.	Corticosterone	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	219-239
35588619-8	2022	Moreover, caffeine could reduce the expression of 11beta-HSD2 by inhibiting the cAMP/PKA signaling pathway but without reducing the H3K9ac and H3K27ac levels of 11beta-HSD2, thereby synergistically enhancing the corticosterone effect.	Corticosterone	212-226	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	50-61
35510321-8	2022	Corticosterone-treated mice had significantly higher body weight (p <= 0.05) and BAT mass (p <= 0.05), increased adipocyte area (p <= 0.05), were insulin resistant (p <= 0.05), and significantly elevated expressions of uncoupling protein 1 (UCP-1) in BAT (p <= 0.05) while mitochondrial content remained unchanged.	Corticosterone	0-14	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	241-246
35172007-6	2022	We measured klf9 mRNA following exposures to triiodothyronine (T3), corticosterone (CORT), and TCDD in the Xenopus laevis cell line XLK-WG.	Corticosterone	68-82	Kruppel-like factor 9 L homeolog	Xenopus laevis	12-16
35571367-6	2022	Finally, male and female SEPT14 KO mice displayed dampened observational fear conditioning magnitude and learning-provoked corticosterone secretion as compared to their same-sex WT mice.	Corticosterone	123-137	septin 14	Mus musculus	25-31
35563271-6	2022	In the model, hepatic 11-betaHSD-1 was considered a key factor in defining the dynamics of plasma corticosterone.	Corticosterone	98-112	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	22-34
35563271-7	2022	In turn, plasma corticosterone and oxidation of brain ketodienes and conjugated trienes determined the dynamics of brain MAO-A activity, and MAO-A activity determined the dynamics of brain norepinephrine.	Corticosterone	16-30	monoamine oxidase A	Rattus norvegicus	121-126
35563271-9	2022	Solution of the model equations demonstrated that plasma corticosterone is mainly determined by the activity of hepatic 11-betaHSD-1 and, most importantly, that corticosterone plays a critical role in the dynamics of anxiety following repeated stress.	Corticosterone	57-71	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	120-132
35172007-6	2022	We measured klf9 mRNA following exposures to triiodothyronine (T3), corticosterone (CORT), and TCDD in the Xenopus laevis cell line XLK-WG.	Corticosterone	84-88	Kruppel-like factor 9 L homeolog	Xenopus laevis	12-16
35172007-7	2022	klf9 was induced 6-fold by 50 nM T3, 4-fold by 100 nM CORT, and 3-fold by 175 nM TCDD.	Corticosterone	54-58	Kruppel-like factor 9 L homeolog	Xenopus laevis	0-4
35172007-8	2022	Co-treatments of CORT and TCDD or T3 and TCDD induced klf9 7- and 11-fold, respectively, while treatment with all 3 agents induced a 15-fold increase.	Corticosterone	17-21	Kruppel-like factor 9 L homeolog	Xenopus laevis	54-58
35437979-8	2022	Corticosterone pre-treatment enhanced the neuroinflammatory response to OTA in a mineralocorticoid receptor (MR)-dependent mechanism, which is associated with increases in extracellular signal-regulated kinase (ERK) and p38 MAPK activation.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Mus musculus	81-107
35528381-9	2022	Oral administration of corticosterone significantly reduced mRNA levels of LPL and significantly increased the mRNA levels of ATGL in WAT in 29-day-old chicks without affecting plasma NEFA concentrations.	Corticosterone	23-37	lipoprotein lipase	Gallus gallus	75-78
35528381-9	2022	Oral administration of corticosterone significantly reduced mRNA levels of LPL and significantly increased the mRNA levels of ATGL in WAT in 29-day-old chicks without affecting plasma NEFA concentrations.	Corticosterone	23-37	patatin like phospholipase domain containing 2	Gallus gallus	126-130
35528381-10	2022	The addition of corticosterone to primary chicken adipocytes significantly increased mRNA levels of ATGL, whereas mRNA levels of LPL tended to decrease.	Corticosterone	16-30	patatin like phospholipase domain containing 2	Gallus gallus	100-104
35528381-10	2022	The addition of corticosterone to primary chicken adipocytes significantly increased mRNA levels of ATGL, whereas mRNA levels of LPL tended to decrease.	Corticosterone	16-30	lipoprotein lipase	Gallus gallus	129-132
35437979-8	2022	Corticosterone pre-treatment enhanced the neuroinflammatory response to OTA in a mineralocorticoid receptor (MR)-dependent mechanism, which is associated with increases in extracellular signal-regulated kinase (ERK) and p38 MAPK activation.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 2	Mus musculus	109-111
35437979-8	2022	Corticosterone pre-treatment enhanced the neuroinflammatory response to OTA in a mineralocorticoid receptor (MR)-dependent mechanism, which is associated with increases in extracellular signal-regulated kinase (ERK) and p38 MAPK activation.	Corticosterone	0-14	mitogen-activated protein kinase 1	Mus musculus	172-209
35437979-8	2022	Corticosterone pre-treatment enhanced the neuroinflammatory response to OTA in a mineralocorticoid receptor (MR)-dependent mechanism, which is associated with increases in extracellular signal-regulated kinase (ERK) and p38 MAPK activation.	Corticosterone	0-14	mitogen-activated protein kinase 1	Mus musculus	211-214
35437979-8	2022	Corticosterone pre-treatment enhanced the neuroinflammatory response to OTA in a mineralocorticoid receptor (MR)-dependent mechanism, which is associated with increases in extracellular signal-regulated kinase (ERK) and p38 MAPK activation.	Corticosterone	0-14	mitogen-activated protein kinase 14	Mus musculus	220-228
35437979-9	2022	In response to OTA, microglial cells produced pro-inflammatory cytokines and NO, while corticosterone increased OTA-induced ERK and p38 MAPK phosphorylation via MR.	Corticosterone	87-101	mitogen-activated protein kinase 1	Mus musculus	124-127
35437979-9	2022	In response to OTA, microglial cells produced pro-inflammatory cytokines and NO, while corticosterone increased OTA-induced ERK and p38 MAPK phosphorylation via MR.	Corticosterone	87-101	mitogen-activated protein kinase 14	Mus musculus	132-140
35437979-9	2022	In response to OTA, microglial cells produced pro-inflammatory cytokines and NO, while corticosterone increased OTA-induced ERK and p38 MAPK phosphorylation via MR.	Corticosterone	87-101	nuclear receptor subfamily 3, group C, member 2	Mus musculus	161-163
35074305-8	2022	We found that corticosterone resulted in differential changes of proBDNF and mature BDNF in different brain regions and peripheral tissues.	Corticosterone	14-28	brain derived neurotrophic factor	Mus musculus	84-88
35433692-4	2022	This study showed that both mouse embryculture with corticosterone (ECC) and maternal preimplantation restraint stress (PIRS) increased anxiety-like behavior (ALB) while decreasing hippocampal expression of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) in offspring.	Corticosterone	52-66	nuclear receptor subfamily 3, group C, member 1	Mus musculus	207-230
35433692-4	2022	This study showed that both mouse embryculture with corticosterone (ECC) and maternal preimplantation restraint stress (PIRS) increased anxiety-like behavior (ALB) while decreasing hippocampal expression of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) in offspring.	Corticosterone	52-66	nuclear receptor subfamily 3, group C, member 1	Mus musculus	232-234
35433692-4	2022	This study showed that both mouse embryculture with corticosterone (ECC) and maternal preimplantation restraint stress (PIRS) increased anxiety-like behavior (ALB) while decreasing hippocampal expression of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) in offspring.	Corticosterone	52-66	brain derived neurotrophic factor	Mus musculus	240-273
35433692-4	2022	This study showed that both mouse embryculture with corticosterone (ECC) and maternal preimplantation restraint stress (PIRS) increased anxiety-like behavior (ALB) while decreasing hippocampal expression of glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) in offspring.	Corticosterone	52-66	brain derived neurotrophic factor	Mus musculus	275-279
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Corticosterone	87-101	proteasome subunit alpha 2	Gallus gallus	33-38
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Corticosterone	87-101	thiamin pyrophosphokinase 1	Gallus gallus	40-44
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Corticosterone	87-101	metal regulatory transcription factor 1	Gallus gallus	46-50
35393054-7	2022	In the L2 strain, 15 SNPs within PSMA2, TPK1, MTF1, and CUL1 exerted effects on plasma corticosterone and triiodothyronine levels.	Corticosterone	87-101	cullin 1	Gallus gallus	56-60
35074305-0	2022	Effects of corticosterone on BDNF expression and mood behaviours in mice.	Corticosterone	11-25	brain derived neurotrophic factor	Mus musculus	29-33
35074305-4	2022	In the present study, we aimed to examine whether proBDNF and mature BDNF (mBDNF) are altered in the corticosterone-induced depression model in mice.	Corticosterone	101-115	brain derived neurotrophic factor	Mus musculus	69-73
35074305-4	2022	In the present study, we aimed to examine whether proBDNF and mature BDNF (mBDNF) are altered in the corticosterone-induced depression model in mice.	Corticosterone	101-115	brain derived neurotrophic factor	Mus musculus	75-80
35313975-6	2022	More importantly, we found that CORT exposure in cortical neurons resulted in increased levels of apoptosis-related proteins such as cleaved caspase-3.	Corticosterone	32-36	caspase 3	Mus musculus	141-150
35313975-8	2022	Intriguingly, CORT-induced apoptosis involved upstream activation of ER stress proteins such as GRP78, CHOP and ATF4.	Corticosterone	14-18	heat shock protein 5	Mus musculus	96-101
35313975-8	2022	Intriguingly, CORT-induced apoptosis involved upstream activation of ER stress proteins such as GRP78, CHOP and ATF4.	Corticosterone	14-18	DNA-damage inducible transcript 3	Mus musculus	103-107
35313975-8	2022	Intriguingly, CORT-induced apoptosis involved upstream activation of ER stress proteins such as GRP78, CHOP and ATF4.	Corticosterone	14-18	activating transcription factor 4	Mus musculus	112-116
35041806-9	2022	In addition, silencing miR-19b-3p expression in vivo using an antagomir or in vitro using an inhibitor increased Drebrin expression, ameliorated the abnormal dendritic structure and upregulated the spine density in hippocampal CA1 pyramidal neurons of CRS mice and primary hippocampal neurons cultured under CORT stimulation, respectively.	Corticosterone	308-312	drebrin 1	Mus musculus	113-120
35091292-6	2022	Here, using a combination of endogenous knockout and viral rescue, we show that male mice lacking FKBP51 in Pomc-expressing cells exhibit enhanced GR-mediated negative feedback and are protected from age-related disruption of their diurnal corticosterone (CORT) rhythm.	Corticosterone	240-254	FK506 binding protein 5	Mus musculus	98-104
35091292-6	2022	Here, using a combination of endogenous knockout and viral rescue, we show that male mice lacking FKBP51 in Pomc-expressing cells exhibit enhanced GR-mediated negative feedback and are protected from age-related disruption of their diurnal corticosterone (CORT) rhythm.	Corticosterone	256-260	FK506 binding protein 5	Mus musculus	98-104
35091292-6	2022	Here, using a combination of endogenous knockout and viral rescue, we show that male mice lacking FKBP51 in Pomc-expressing cells exhibit enhanced GR-mediated negative feedback and are protected from age-related disruption of their diurnal corticosterone (CORT) rhythm.	Corticosterone	256-260	pro-opiomelanocortin-alpha	Mus musculus	108-112
35091292-6	2022	Here, using a combination of endogenous knockout and viral rescue, we show that male mice lacking FKBP51 in Pomc-expressing cells exhibit enhanced GR-mediated negative feedback and are protected from age-related disruption of their diurnal corticosterone (CORT) rhythm.	Corticosterone	256-260	nuclear receptor subfamily 3, group C, member 1	Mus musculus	147-149
35263131-5	2022	These defects are completely rescued by reconstituting CBG, supporting that KLF15 works primarily through CBG to control plasma corticosterone homeostasis.	Corticosterone	128-142	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	55-58
35263131-5	2022	These defects are completely rescued by reconstituting CBG, supporting that KLF15 works primarily through CBG to control plasma corticosterone homeostasis.	Corticosterone	128-142	Kruppel-like factor 15	Mus musculus	76-81
35263131-5	2022	These defects are completely rescued by reconstituting CBG, supporting that KLF15 works primarily through CBG to control plasma corticosterone homeostasis.	Corticosterone	128-142	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	106-109
35370743-0	2022	Stachyose Alleviates Corticosterone-Induced Long-Term Potentiation Impairment via the Gut-Brain Axis.	Corticosterone	21-35	glucuronidase, beta	Mus musculus	86-89
35370743-6	2022	16S rRNA sequencing, alpha diversity, and principal coordinate analysis (PCoA) revealed that the gut flora in corticosterone-treated mice was disturbed and stachyose could improve corticosterone-induced gut flora disturbance.	Corticosterone	110-124	glucuronidase, beta	Mus musculus	97-100
35370743-6	2022	16S rRNA sequencing, alpha diversity, and principal coordinate analysis (PCoA) revealed that the gut flora in corticosterone-treated mice was disturbed and stachyose could improve corticosterone-induced gut flora disturbance.	Corticosterone	180-194	glucuronidase, beta	Mus musculus	203-206
35370743-11	2022	These results indicated that stachyose might indirectly increase D-serine release through the gut-brain axis to improve LTP impairment by corticosterone in the hippocampus in vivo.	Corticosterone	138-152	glucuronidase, beta	Mus musculus	94-97
35263051-3	2022	We highlight the presence of a "mineralocorticoid (MC) pathway of zona fasciculata (ZF)", where most circulating corticosterone and deoxycorticosterone (DOC) originate together with 18OHDOC, under ACTH control, a claim based on functional studies in normal subjects and in patients with 11beta-, and 17alpha-hydroxylase deficiencies.	Corticosterone	113-127	proopiomelanocortin	Homo sapiens	197-201
35255992-0	2022	Chronic corticosterone disrupts the circadian rhythm of CRH expression and m6A RNA methylation in the chicken hypothalamus.	Corticosterone	8-22	corticotropin releasing hormone	Gallus gallus	56-59
35255992-3	2022	RESULTS: Chronic exposure to corticosterone (CORT) eliminated the diurnal patterns of plasma CORT and melatonin levels in the chicken.	Corticosterone	29-43	CORT	Gallus gallus	45-49
35255992-3	2022	RESULTS: Chronic exposure to corticosterone (CORT) eliminated the diurnal patterns of plasma CORT and melatonin levels in the chicken.	Corticosterone	29-43	CORT	Gallus gallus	93-97
35281603-0	2022	A Famous Chinese Medicine Formula: Yinhuo Decoction Antagonizes the Damage of Corticosterone to PC12 Cells and Improves Depression by Regulating the SIRT1/PGC-1alpha Pathway.	Corticosterone	78-92	sirtuin 1	Rattus norvegicus	149-154
35281603-13	2022	Mechanically, we confirmed that Yinhuo Decoction reduced CORT-induced PC12 damage by regulating SIRT1/PGC-1alpha pathway.	Corticosterone	57-61	sirtuin 1	Rattus norvegicus	96-101
35281603-13	2022	Mechanically, we confirmed that Yinhuo Decoction reduced CORT-induced PC12 damage by regulating SIRT1/PGC-1alpha pathway.	Corticosterone	57-61	PPARG coactivator 1 alpha	Rattus norvegicus	102-112
34990712-2	2022	ABCB1 (expressed in brain) exports cortisol not corticosterone while ABCC1 (expressed in adipose and skeletal muscle) exports corticosterone not cortisol.	Corticosterone	126-140	ATP binding cassette subfamily C member 1	Homo sapiens	69-74
34990712-3	2022	We hypothesised that ABCC1 inhibition increases corticosteroid receptor occupancy by corticosterone but not cortisol in humans.	Corticosterone	85-99	ATP binding cassette subfamily C member 1	Homo sapiens	21-26
34990712-11	2022	CONCLUSIONS: Although displacement of corticosterone and/or cortisol from receptors in adipose and skeletal muscle could not be measured with sufficient precision to detect effects of probenecid, ABCC1 inhibition induced a greater incremental activation of the hypothalamic-pituitary-adrenal axis after combined receptor blockade, consistent with ABCC1 exporting corticosterone from the pituitary and adding to the evidence that ABC transporters modulate tissue glucocorticoid sensitivity.	Corticosterone	38-52	ATP binding cassette subfamily C member 1	Homo sapiens	196-201
34990712-11	2022	CONCLUSIONS: Although displacement of corticosterone and/or cortisol from receptors in adipose and skeletal muscle could not be measured with sufficient precision to detect effects of probenecid, ABCC1 inhibition induced a greater incremental activation of the hypothalamic-pituitary-adrenal axis after combined receptor blockade, consistent with ABCC1 exporting corticosterone from the pituitary and adding to the evidence that ABC transporters modulate tissue glucocorticoid sensitivity.	Corticosterone	38-52	ATP binding cassette subfamily C member 1	Homo sapiens	347-352
34990712-11	2022	CONCLUSIONS: Although displacement of corticosterone and/or cortisol from receptors in adipose and skeletal muscle could not be measured with sufficient precision to detect effects of probenecid, ABCC1 inhibition induced a greater incremental activation of the hypothalamic-pituitary-adrenal axis after combined receptor blockade, consistent with ABCC1 exporting corticosterone from the pituitary and adding to the evidence that ABC transporters modulate tissue glucocorticoid sensitivity.	Corticosterone	363-377	ATP binding cassette subfamily C member 1	Homo sapiens	196-201
35143549-5	2022	These changes in POMC neuronal functions were associated with increased plasma corticosterone response to restraint stress and increased anxiety-like behavior.	Corticosterone	79-93	proopiomelanocortin	Rattus norvegicus	17-21
35163125-7	2022	Uptake of MPP+ by OCTs induced concentration-dependent changes in cellular impedance that were inhibited by decynium-22, corticosterone, and Tyrosine Kinase inhibitors.	Corticosterone	121-135	M-phase phosphoprotein 6	Homo sapiens	10-13
35123977-13	2022	Decreased serum corticosterone levels observed with SOV (5 & 10 mg/kg), FLX-10 mg/kg, FLX (10 mg/kg) + SOV (5 mg/kg); and SOV-10 mg/kg per-se treatment and elevated BDNF level with SOV (5 & 10 mg/kg), FLX-10 mg/kg were associated with attenuation of depressive-like behavior.	Corticosterone	16-30	brain derived neurotrophic factor	Mus musculus	165-169
35146079-8	2022	Following CUS, 10 min of restraint stress increased plasma corticosterone levels only in CNTF+/+ females.	Corticosterone	59-73	ciliary neurotrophic factor	Mus musculus	89-93
35128742-8	2022	Here, we review the evidence for and against the action of a handful of signaling molecules as inhibitors of GnRH neuron function, including corticotropin-releasing hormone, urocortins, norepinephrine, cortisol/corticosterone, calcitonin gene-related peptide and arginine-phenylalanine-amide-related peptide-3.	Corticosterone	211-225	gonadotropin releasing hormone 1	Homo sapiens	109-113
34983931-12	2022	Cinnamaldehyde administration reversed CORT-induced GR reduction in testis, miR-190b upregulation in testis and sperm, pre-miR-190b upregulation in testis, and the amount of GR on miR-190b promoter regions of F0 males.	Corticosterone	39-43	nuclear receptor subfamily 3, group C, member 1	Mus musculus	52-54
34983931-12	2022	Cinnamaldehyde administration reversed CORT-induced GR reduction in testis, miR-190b upregulation in testis and sperm, pre-miR-190b upregulation in testis, and the amount of GR on miR-190b promoter regions of F0 males.	Corticosterone	39-43	microRNA 190b	Mus musculus	76-84
34983931-12	2022	Cinnamaldehyde administration reversed CORT-induced GR reduction in testis, miR-190b upregulation in testis and sperm, pre-miR-190b upregulation in testis, and the amount of GR on miR-190b promoter regions of F0 males.	Corticosterone	39-43	microRNA 190b	Mus musculus	123-131
34983931-12	2022	Cinnamaldehyde administration reversed CORT-induced GR reduction in testis, miR-190b upregulation in testis and sperm, pre-miR-190b upregulation in testis, and the amount of GR on miR-190b promoter regions of F0 males.	Corticosterone	39-43	nuclear receptor subfamily 3, group C, member 1	Mus musculus	174-176
34791109-0	2022	Glucocorticoid receptor antagonist alters corticosterone and receptor sensitive mRNAs in the hypoxic neonatal rat.	Corticosterone	42-56	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	0-23
34791109-3	2022	We evaluated a selective glucocorticoid receptor (GR) antagonist (CORT113176) in our neonatal rat model of human prematurity to assess how fasting and hypoxia-induced increases in neonatal corticosterone affects endogenous hormones and endocrine pancreas function.	Corticosterone	189-203	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	50-52
34861075-0	2022	Central role of intestinal epithelial glucocorticoid receptor in alcohol- and corticosterone-induced gut permeability and systemic response.	Corticosterone	78-92	nuclear receptor subfamily 3, group C, member 1	Mus musculus	38-61
35013761-7	2022	Corticosterone levels were evaluated in plasma and oxidative stress parameters; monoamine oxidase (MAO)-A and MAO -B isoform activity; mRNA expression levels of kappa nuclear factor B (NF-kappaB); interleukin (IL)-1beta, IL-18, and IL-33; phosphatidylinositol-se-kinase (PI3K); protein kinase B (AKT2), as well as acetylcholinesterase activity were evaluated in the prefrontal cortex and hippocampus.	Corticosterone	0-14	interleukin 1 alpha	Mus musculus	197-219
35013761-7	2022	Corticosterone levels were evaluated in plasma and oxidative stress parameters; monoamine oxidase (MAO)-A and MAO -B isoform activity; mRNA expression levels of kappa nuclear factor B (NF-kappaB); interleukin (IL)-1beta, IL-18, and IL-33; phosphatidylinositol-se-kinase (PI3K); protein kinase B (AKT2), as well as acetylcholinesterase activity were evaluated in the prefrontal cortex and hippocampus.	Corticosterone	0-14	interleukin 18	Mus musculus	221-226
35013761-7	2022	Corticosterone levels were evaluated in plasma and oxidative stress parameters; monoamine oxidase (MAO)-A and MAO -B isoform activity; mRNA expression levels of kappa nuclear factor B (NF-kappaB); interleukin (IL)-1beta, IL-18, and IL-33; phosphatidylinositol-se-kinase (PI3K); protein kinase B (AKT2), as well as acetylcholinesterase activity were evaluated in the prefrontal cortex and hippocampus.	Corticosterone	0-14	interleukin 33	Mus musculus	232-237
35013761-7	2022	Corticosterone levels were evaluated in plasma and oxidative stress parameters; monoamine oxidase (MAO)-A and MAO -B isoform activity; mRNA expression levels of kappa nuclear factor B (NF-kappaB); interleukin (IL)-1beta, IL-18, and IL-33; phosphatidylinositol-se-kinase (PI3K); protein kinase B (AKT2), as well as acetylcholinesterase activity were evaluated in the prefrontal cortex and hippocampus.	Corticosterone	0-14	thymoma viral proto-oncogene 2	Mus musculus	296-300
35187416-9	2022	Compared to the wild-type human PR, there was an increase in the activation of human Gly722Cys PR by11-deoxycortisol and a decrease in activation by corticosterone, which may have been important in selection for the mutation corresponding to the human glycine-722 PR that first evolved in the platypus PR, a basal mammal.	Corticosterone	149-163	transmembrane protein 37	Homo sapiens	32-34
35187416-9	2022	Compared to the wild-type human PR, there was an increase in the activation of human Gly722Cys PR by11-deoxycortisol and a decrease in activation by corticosterone, which may have been important in selection for the mutation corresponding to the human glycine-722 PR that first evolved in the platypus PR, a basal mammal.	Corticosterone	149-163	transmembrane protein 37	Homo sapiens	264-266
35158333-8	2021	Both metyrapone and NBI 27914 injected shortly before CRH administration caused an inhibition of CRH-induced corticosterone response and prevented protective effect of CRH on the gastric mucosa against the IM-induced erosion.	Corticosterone	109-123	corticotropin releasing hormone	Rattus norvegicus	97-100
2610823-2	1989	Corticotropin-releasing factor (CRF) administered intracerebroventricularly produced both a rapid, greater than 50% reduction in splenic natural killer (NK) cytotoxicity and a prolonged elevation in plasma corticosterone levels.	Corticosterone	206-220	corticotropin releasing hormone	Rattus norvegicus	0-30
34996981-9	2022	The expression of all five genes, except APOL4, was successfully validated with qPCR in CORT-treated rat PFC.	Corticosterone	88-92	apolipoprotein L4	Homo sapiens	41-46
34996981-10	2022	Further, Hdac6-based ChIP-seq experiment helped in mapping major genomic loci enriched for intergenic regions in the PFC of CORT-treated rat.	Corticosterone	124-128	histone deacetylase 6	Rattus norvegicus	9-14
34996981-12	2022	Our results suggest that the upregulation of miR-218-5p in PFC of CORT-treated rats possibly resulted from GR biding in the promoter region of Slit3 gene.	Corticosterone	66-70	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	107-109
34996981-12	2022	Our results suggest that the upregulation of miR-218-5p in PFC of CORT-treated rats possibly resulted from GR biding in the promoter region of Slit3 gene.	Corticosterone	66-70	slit guidance ligand 3	Rattus norvegicus	143-148
2611695-1	1989	The glucocorticoid corticosterone (CORT) plays a major role in feeding behavior, body weight regulation and metabolism.	Corticosterone	19-33	cortistatin	Rattus norvegicus	35-39
35097015-6	2021	11betaHSD1 deletion (Hsd11b1Del1/Del1) or pharmacological inhibition (with 300 nM UE2316) which block the reactivation of glucocorticoid (i.e., the conversion of 11-dehydrocorticosterone (11DHC) to bioactive corticosterone) significantly reduced 11DHC-induced suppression of angiogenesis.	Corticosterone	208-222	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-10
35097015-6	2021	11betaHSD1 deletion (Hsd11b1Del1/Del1) or pharmacological inhibition (with 300 nM UE2316) which block the reactivation of glucocorticoid (i.e., the conversion of 11-dehydrocorticosterone (11DHC) to bioactive corticosterone) significantly reduced 11DHC-induced suppression of angiogenesis.	Corticosterone	208-222	collagen, type II, alpha 1	Mus musculus	21-32
2531971-5	1989	Histamine, 2-pyridylethylamine (PEA), a histamine H1-receptor agonist, and 4-methylhistamine (MeHA) and dimaprit, H2-receptor agonists, significantly intensified the stress-induced increase in serum corticosterone levels.	Corticosterone	199-213	histamine receptor H 1	Rattus norvegicus	40-61
2698528-5	1989	The equilibrium redistribution is revealed in the plasma between free corticosterone and corticosterone bound to transcortin at the different stages of the hypoxic exposure.	Corticosterone	89-103	serpin family A member 6	Rattus norvegicus	113-124
2558305-2	1989	The type I receptor binds corticosterone with high affinity and is structurally related to the kidney mineralocorticoid receptor (MR), while the type II or classical glucocorticoid receptor binds corticosterone with lower affinity and displays an in vivo preference for dexamethasone.	Corticosterone	26-40	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	102-128
2558305-2	1989	The type I receptor binds corticosterone with high affinity and is structurally related to the kidney mineralocorticoid receptor (MR), while the type II or classical glucocorticoid receptor binds corticosterone with lower affinity and displays an in vivo preference for dexamethasone.	Corticosterone	26-40	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	130-132
2558305-2	1989	The type I receptor binds corticosterone with high affinity and is structurally related to the kidney mineralocorticoid receptor (MR), while the type II or classical glucocorticoid receptor binds corticosterone with lower affinity and displays an in vivo preference for dexamethasone.	Corticosterone	26-40	nuclear receptor subfamily 3 group C member 1	Homo sapiens	166-189
2558305-2	1989	The type I receptor binds corticosterone with high affinity and is structurally related to the kidney mineralocorticoid receptor (MR), while the type II or classical glucocorticoid receptor binds corticosterone with lower affinity and displays an in vivo preference for dexamethasone.	Corticosterone	196-210	nuclear receptor subfamily 3 group C member 1	Homo sapiens	166-189
2558305-5	1989	Southern analysis suggests that there is only one gene for the MR, and in vitro expression of the receptor generates a high affinity corticosterone-binding protein.	Corticosterone	133-147	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	63-65
2558326-3	1989	Rats chronically cannulated in the right jugular veins showed a time-related increase in plasma corticosterone concentrations in response to intraperitoneal administration of IL-1 that lasted up to 4 h. In the same rats, plasma epinephrine (E) and norepinephrine (NE) concentrations were only slightly elevated (2-fold increase) at 30 min and at 1 h after IL-1 administration.	Corticosterone	96-110	interleukin 1 complex	Mus musculus	175-179
2804697-0	1989	Suppression of neuropeptide Y-elicited eating by adrenalectomy or hypophysectomy: reversal with corticosterone.	Corticosterone	96-110	neuropeptide Y	Rattus norvegicus	15-29
2804697-4	1989	In ADX groups, the NPY-elicited response was reduced by 60-71%, to between 2.4 and 2.8 g. Likewise, the average response of the HYPX group was reduced by 69%, to 1.7 g. Corticosterone replacement, via subcutaneous implant of a 100 mg CORT pellet, normalized the NPY-induced feeding response in both the ADX and HYPX groups.	Corticosterone	169-183	neuropeptide Y	Rattus norvegicus	19-22
2551656-18	1989	Pretreatment with glucocorticoids (100 nM corticosterone) for 15 h blocked CRH-mediated secretion in all cultures.	Corticosterone	42-56	corticotropin releasing hormone	Homo sapiens	75-78
2549056-7	1989	In vivo the SAP content of adrenals from quiescent rats is concordant with the circadian rhythm of the pituitary-adrenal axis; at the apex (1800 h), adrenal SAP is 13-fold higher than at the nadir (0800 h), paralleling 2- and 7-fold variations in cholesterol side-chain cleavage activity and serum corticosterone levels, respectively.	Corticosterone	298-312	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	12-15
2605494-1	1989	This study investigated the impact of chronic adrenalectomy (ADX), and subsequent corticosterone (CORT) replacement to ADX rats, on brain levels of norepinephrine (NE) and dopamine (DA) and their extent of depletion after alpha-methyl-p-tyrosine (alpha-MpT) administration.	Corticosterone	82-96	cortistatin	Rattus norvegicus	98-102
2777023-10	1989	These data, therefore, indicate that physiologic concentrations of plasma corticosterone decrease pancreatic kallikrein mRNA levels in vivo, and that this is a direct effect on pancreatic acinar cells.	Corticosterone	74-88	kallikrein 1-related peptidase B3	Rattus norvegicus	98-119
2547578-8	1989	These results suggest that adrenocortical function is enhanced in young SHR, that reduced ACTH response to stress and exogenous CRH in SHR may be ascribed to higher plasma corticosterone levels, and that corticosterone is essential for the development of hypertension in SHR.	Corticosterone	172-186	corticotropin releasing hormone	Rattus norvegicus	128-131
2681261-5	1989	Exogenous administration of either IL-1 or TNF could induce increases in serum corticosterone in sham-operated mice.	Corticosterone	79-93	interleukin 1 complex	Mus musculus	35-39
2788078-5	1989	The present study suggests that ppCRH mRNA in the PVH may respond in a similar way to fluctuating concentrations of plasma corticosterone throughout the day, and that although the exact mechanism remains to be elucidated, diurnal changes in the rate of CRH synthesis may be involved in the expression of diurnal rhythms within the hypothalamo-hypophysial-adrenal axis.	Corticosterone	123-137	corticotropin releasing hormone	Rattus norvegicus	34-37
2583669-3	1989	Both the vehicle treated and corticosterone treated db/db and ob/ob mice had lower body weights than the sham-operated mice GDP binding to mitochondria from IBAT was significantly lower in both the db/db and ob/ob mice than in their lean controls.	Corticosterone	29-43	solute carrier family 10, member 2	Mus musculus	157-161
2598356-6	1989	The response of the cultured adrenocortical cells to secret corticosterone to the stimulation of ACTH analogue was also significantly lower in the aged rats than that in the young rats, which suggests that the reserve power of the adrenal cortex was also decreased with aging.	Corticosterone	60-74	proopiomelanocortin	Homo sapiens	97-101
2681261-5	1989	Exogenous administration of either IL-1 or TNF could induce increases in serum corticosterone in sham-operated mice.	Corticosterone	79-93	tumor necrosis factor	Mus musculus	43-46
2681261-6	1989	Finally, treatment of adrenalectomized mice with corticosterone or dexamethasone could inhibit the induction of serum IL-1 and TNF and modified the pattern of these cytokine-induced deaths.	Corticosterone	49-63	interleukin 1 complex	Mus musculus	118-122
2681261-6	1989	Finally, treatment of adrenalectomized mice with corticosterone or dexamethasone could inhibit the induction of serum IL-1 and TNF and modified the pattern of these cytokine-induced deaths.	Corticosterone	49-63	tumor necrosis factor	Mus musculus	127-130
2681261-8	1989	Taken together, these data provide in vivo evidence for a feedback system involving the neuroendocrine axis (hypothalamus, pituitary and adrenal glands) leading to corticosterone production and subsequent regulation and/or modulation of IL-1 or TNF levels or activity.	Corticosterone	164-178	tumor necrosis factor	Mus musculus	245-248
2765916-2	1989	Corticosterone administration to adult rats resulted in decreased levels of GFAP throughout the brain whereas adrenalectomy caused levels of GFAP to increase.	Corticosterone	0-14	glial fibrillary acidic protein	Rattus norvegicus	76-80
2548411-3	1989	The ACTH response to induced hypoglycemia was measured after no prior corticosteroid feedback signal or after a corticosteroid feedback signal produced by infusion, two bolus injections, or three bolus injections of cortisol and corticosterone.	Corticosterone	229-243	proopiomelanocortin	Canis lupus familiaris	4-8
2758635-2	1989	CBG was purified from pooled human serum by precipitation with ammonium sulfate and successive affinity chromatography treatments on corticosterone-Sepharose and concanavalin A-Sepharose.	Corticosterone	133-147	serpin family A member 6	Homo sapiens	0-3
2765916-3	1989	Corticosterone administration to adrenalectomized rats lowered GFAP levels to values below those of sham controls.	Corticosterone	0-14	glial fibrillary acidic protein	Rattus norvegicus	63-67
2533356-0	1989	Selective cross-tolerance to 5-HT1A and 5-HT2 receptor-mediated temperature and corticosterone responses.	Corticosterone	80-94	5-hydroxytryptamine receptor 1A	Homo sapiens	29-54
2633980-9	1989	On the withdrawal of corticosterone treatment, all the lipid classes turned to normalcy along with serum testosterone and prolactin.	Corticosterone	21-35	prolactin	Rattus norvegicus	122-131
2550833-10	1989	The present study thus shows that (1) the anti-glucocorticoid RU38486 via the brain GR has no effect on the basal plasma corticosterone level in the morning but interferes with a glucocorticoid negative feedback following stress and (2) the anti-mineralocorticoid RU28318 via the brain MR elevates the basal plasma corticosterone level and enhances adrenocortical secretion following stress.	Corticosterone	315-329	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	84-86
2550834-9	1989	Corticosterone secretion also increased after stimulation at both frequencies, but the response was observed only during infusion of 10 ng/min ACTH.	Corticosterone	0-14	proopiomelanocortin	Canis lupus familiaris	143-147
2546734-3	1989	PAF injected iv to rats (125, 250, and 500 ng/100 g BW) caused significant stimulation of pituitary ACTH and adrenal corticosterone secretion.	Corticosterone	117-131	PCNA clamp associated factor	Rattus norvegicus	0-3
2533356-6	1989	Thus, data presented in these studies are suggestive that the chronic administration of 5-MeODMT diminishes the responsiveness of 5-HT1A receptor-mediated changes in body temperature and corticosterone secretion without altering the responses mediated by 5-HT2 receptors.	Corticosterone	187-201	5-hydroxytryptamine receptor 1A	Homo sapiens	130-145
2533356-7	1989	In contrast, the chronic administration of DOI selectively diminishes the magnitude of 5-HT2 receptor-mediated changes in corticosterone secretion without affecting the responsiveness of those receptors involved in thermoregulatory responses.	Corticosterone	122-136	5-hydroxytryptamine receptor 2A	Homo sapiens	87-101
2594422-2	1989	Analgin and aminopyrine in doses of 10(-2) and 10(-3) increase the specific binding of labelled corticosterone by type-III glucocorticoid receptors of the hepatic cytosol and by blood plasma transcortin in modelled experiments.	Corticosterone	96-110	serpin family A member 6	Rattus norvegicus	191-202
2569487-4	1989	In the first series of experiments, the time-course of corticosterone replacement effects on corticotropin-releasing hormone (CRH) mRNA levels in parvicellular neuroendocrine cells of adrenalectomized animals were determined, and a dose-response curve was established.	Corticosterone	55-69	corticotropin releasing hormone	Rattus norvegicus	93-124
2569487-4	1989	In the first series of experiments, the time-course of corticosterone replacement effects on corticotropin-releasing hormone (CRH) mRNA levels in parvicellular neuroendocrine cells of adrenalectomized animals were determined, and a dose-response curve was established.	Corticosterone	55-69	corticotropin releasing hormone	Rattus norvegicus	126-129
2569487-6	1989	We confirmed that corticosterone decreases vasopressin mRNA levels in this cell group and showed that levels of preproenkephalin mRNA are also decreased, whereas no significant changes in cholecystokinin, beta-preprotachykinin, and angiotensinogen mRNA levels could be detected.	Corticosterone	18-32	arginine vasopressin	Rattus norvegicus	43-54
2569487-6	1989	We confirmed that corticosterone decreases vasopressin mRNA levels in this cell group and showed that levels of preproenkephalin mRNA are also decreased, whereas no significant changes in cholecystokinin, beta-preprotachykinin, and angiotensinogen mRNA levels could be detected.	Corticosterone	18-32	angiotensinogen	Rattus norvegicus	232-247
2544415-4	1989	Binding of DIL-HDL3 and DIL-LDL was saturable and specific, and resulted in enhanced secretion of corticosterone and 18-hydroxydeoxycorticosterone, indicating that the binding sites for these lipoproteins represented functional receptors.	Corticosterone	98-112	HDL3	Homo sapiens	15-19
2815668-3	1989	Both low 10(-11) 10(-13) M and high 10(-5) 10(-6) M concentrations of corticosterone stimulated the MAO A deamination of serotonin, while the steroid high concentrations inhibited the MAO B deamination of benzylamine either in vitro and in vivo (after intraperitoneal administration of 5 mg/kg).	Corticosterone	70-84	monoamine oxidase A	Rattus norvegicus	100-105
2815668-3	1989	Both low 10(-11) 10(-13) M and high 10(-5) 10(-6) M concentrations of corticosterone stimulated the MAO A deamination of serotonin, while the steroid high concentrations inhibited the MAO B deamination of benzylamine either in vitro and in vivo (after intraperitoneal administration of 5 mg/kg).	Corticosterone	70-84	monoamine oxidase B	Rattus norvegicus	184-189
2815668-4	1989	Actinomycin D blocked the stimulating effect of corticosterone at low concentrations on the MAO A activity, whereas the drug did not affect both the alterations in the MAO A and B activities observed after 5 hrs stress and the inhibition of MAO B by high concentrations of corticosterone.	Corticosterone	48-62	monoamine oxidase A	Rattus norvegicus	92-97
2547012-2	1989	Both desacetyl-alpha-MSH, thought to be the major form of the peptide in the human pituitary and in circulating plasma, and alpha-MSH caused a significant stimulation of aldosterone, corticosterone and cortisol secretion.	Corticosterone	183-197	proopiomelanocortin	Homo sapiens	15-24
2547114-1	1989	Six-hour infusion with ACTH or CRH induced a dose-dependent rise in the plasma concentrations of ACTH, corticosterone (B) and aldosterone (A).	Corticosterone	103-117	corticotropin releasing hormone	Rattus norvegicus	31-34
2549437-0	1989	Neurotensin activates tuberoinfundibular dopamine neurons and increases serum corticosterone concentrations in the rat.	Corticosterone	78-92	neurotensin	Rattus norvegicus	0-11
2549437-5	1989	Serum concentrations of corticosterone in rats treated with neurotensin (1-20 micrograms i.c.v.)	Corticosterone	24-38	neurotensin	Rattus norvegicus	60-71
2569487-13	1989	In contrast, while corticosterone depresses vasopressin mRNA levels in parvicellular CRH neurons, it has no obvious effects on vasopressin mRNA levels in magnocellular or descending neurons; as with CRH, the effects of corticosterone on vasopressin mRNA levels are cell-type specific.	Corticosterone	19-33	arginine vasopressin	Rattus norvegicus	44-55
2569487-13	1989	In contrast, while corticosterone depresses vasopressin mRNA levels in parvicellular CRH neurons, it has no obvious effects on vasopressin mRNA levels in magnocellular or descending neurons; as with CRH, the effects of corticosterone on vasopressin mRNA levels are cell-type specific.	Corticosterone	19-33	corticotropin releasing hormone	Rattus norvegicus	85-88
2547012-2	1989	Both desacetyl-alpha-MSH, thought to be the major form of the peptide in the human pituitary and in circulating plasma, and alpha-MSH caused a significant stimulation of aldosterone, corticosterone and cortisol secretion.	Corticosterone	183-197	proopiomelanocortin	Homo sapiens	124-133
2547012-6	1989	Yields of steroid obtained under conditions of maximal stimulation by ACTH(1-24), alpha-MSH and desacetyl-alpha-MSH were at least three to five times the basal output of aldosterone, four to eight times that for corticosterone and more than seven to sixteen times that for cortisol.	Corticosterone	212-226	proopiomelanocortin	Homo sapiens	106-115
2544045-7	1989	Hypothalamic norepinephrine and serum corticosterone levels increased in a dose-related manner after 2 weeks of T-2 exposure.	Corticosterone	38-52	brachyury 2	Mus musculus	112-115
2544045-6	1989	Blood levels of corticosterone, indicative of the stress-response, increased 24 h after T-2 exposure.	Corticosterone	16-30	brachyury 2	Mus musculus	88-91
2497651-5	1989	These data demonstrate that physiological levels of corticosterone (40% pellet) restore vascular responsiveness, body weight, thymus weight, and transcortin levels to normal in ADRX rats, whereas higher levels (80% pellet) are necessary for restoration of the baroreflex.	Corticosterone	52-66	serpin family A member 6	Rattus norvegicus	145-156
2707168-0	1989	Roles of plasma clearance and corticosteroid-binding globulin in the developmental increase in circulating corticosterone in infant rats.	Corticosterone	107-121	serpin family A member 6	Homo sapiens	30-61
2707168-7	1989	The declining MCR for corticosterone with increasing age is due primarily to a decrease in the apparent volume of distribution (Vd), which, in turn, may result from the concurrent increase in plasma corticosteroid-binding globulin (CBG).	Corticosterone	22-36	serpin family A member 6	Homo sapiens	199-230
2707168-7	1989	The declining MCR for corticosterone with increasing age is due primarily to a decrease in the apparent volume of distribution (Vd), which, in turn, may result from the concurrent increase in plasma corticosteroid-binding globulin (CBG).	Corticosterone	22-36	serpin family A member 6	Homo sapiens	232-235
2707168-11	1989	Moreover, increased binding of corticosterone to CBG appears to be responsible for decreases in Vd and clearance.	Corticosterone	31-45	serpin family A member 6	Homo sapiens	49-52
2549116-2	1989	The present study has been designed in order to see if A II could modify in vitro spontaneous and ACTH-induced corticosterone (B) release from both fasciculata-reticularis enriched and total adrenal cells.	Corticosterone	111-125	NLR family pyrin domain containing 3	Homo sapiens	55-59
2549116-2	1989	The present study has been designed in order to see if A II could modify in vitro spontaneous and ACTH-induced corticosterone (B) release from both fasciculata-reticularis enriched and total adrenal cells.	Corticosterone	111-125	proopiomelanocortin	Homo sapiens	98-102
2724132-8	1989	A positive correlation was observed between serum prolactin levels and Con A-induced proliferation as well as between serum prolactin and corticosterone levels in cysteamine-treated mice.	Corticosterone	138-152	prolactin	Mus musculus	124-133
2724956-0	1989	Comparison of the biopotency of corticosterone and dexamethasone acetate in glucocorticoid receptor down regulation in rat liver.	Corticosterone	32-46	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	76-99
2538425-7	1989	Other glucocorticoids, such as hydrocortisone and corticosterone, had a similar effect to dexamethasone on plasmin binding to HT-1080 cells.	Corticosterone	50-64	plasminogen	Homo sapiens	107-114
2530590-0	1989	Stimulation of corticosterone secretion by the selective 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the rat.	Corticosterone	15-29	5-hydroxytryptamine receptor 1A	Rattus norvegicus	57-63
2530590-1	1989	The selective 5-HT1A receptor agonist 8-OH-DPAT increased serum corticosterone concentration in rats in a dose-dependent manner.	Corticosterone	64-78	5-hydroxytryptamine receptor 1A	Rattus norvegicus	14-20
2530590-3	1989	The corticosterone response to 8-OH-DPAT was also antagonized by spiperone, (+/-)- and (-)-pindolol and (+/-)-propranolol, all of which have been shown to have a high affinity for 5-HT1A receptors, though in most cases no complete blockade was found.	Corticosterone	4-18	5-hydroxytryptamine receptor 1A	Rattus norvegicus	180-186
2530590-7	1989	It is concluded that 8-OH-DPAT-induced increase in serum corticosterone concentration results from its action at a site different than the adrenal cortex and is mediated by postsynaptic 5-HT1A receptors, whereas other subtypes (5-HT1B, 5-HT2, 5-HT3) of 5-HT receptors do not participate in this response.	Corticosterone	57-71	5-hydroxytryptamine receptor 1A	Rattus norvegicus	186-192
2724956-1	1989	The effects of long treatment with dexamethasone 21-acetate and corticosterone on the glucocorticoid receptor in rat liver cytosol were compared.	Corticosterone	64-78	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	86-109
2924145-9	1989	The results suggest that the lack of vasopressin in DI rats elevates baseline NK cell activity, probably via mechanisms that are secondary to the vasopressin deficiency (e.g. lower corticosterone levels).	Corticosterone	181-195	arginine vasopressin	Rattus norvegicus	37-48
2543538-4	1989	Human ACTH-(1-24) was the most efficacious and potent ACTH analogue for stimulating corticosterone and cAMP production, whereas turkey ACTH-(1-39) was among the least efficacious and least potent analogues.	Corticosterone	84-98	proopiomelanocortin	Homo sapiens	54-58
2543538-4	1989	Human ACTH-(1-24) was the most efficacious and potent ACTH analogue for stimulating corticosterone and cAMP production, whereas turkey ACTH-(1-39) was among the least efficacious and least potent analogues.	Corticosterone	84-98	proopiomelanocortin	Homo sapiens	54-58
2543538-8	1989	Basal corticosterone production of female cells was 19% greater than that of male cells, albeit maximal ACTH analogue-induced corticosterone production was not different between male and female cells.	Corticosterone	126-140	proopiomelanocortin	Homo sapiens	104-108
2543538-11	1989	In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells.	Corticosterone	89-103	proopiomelanocortin	Homo sapiens	68-72
2543538-11	1989	In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells.	Corticosterone	89-103	proopiomelanocortin	Homo sapiens	126-130
2543538-11	1989	In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells.	Corticosterone	89-103	proopiomelanocortin	Homo sapiens	126-130
2543538-11	1989	In addition, there were sex-dependent differences in sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity to ACTH as indicated by corticosterone and cAMP responses to ACTH analogues: sensitivity of male cells was 1.2-3.2 times that of female cells.	Corticosterone	89-103	proopiomelanocortin	Homo sapiens	126-130
2538536-0	1989	Effects of insulin, glucose and ACTH on corticosterone production by fetal adrenal cells from diabetic rats.	Corticosterone	40-54	proopiomelanocortin	Homo sapiens	32-36
2538536-10	1989	Human ACTH (0.02-20 nmol/l) caused a concentration-dependent increase in corticosterone output of comparable magnitude by cells from all three groups of animals.	Corticosterone	73-87	proopiomelanocortin	Homo sapiens	6-10
2927386-6	1989	Chronic corticosterone was also found to increase levels of immunoreactivity of c-src, a well characterized protein tyrosine kinase, in the LC, results indicating that corticosterone increases protein tyrosine kinase activity in this brain region at least in part by increasing the total amount of this enzyme.	Corticosterone	8-22	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	80-85
2927386-6	1989	Chronic corticosterone was also found to increase levels of immunoreactivity of c-src, a well characterized protein tyrosine kinase, in the LC, results indicating that corticosterone increases protein tyrosine kinase activity in this brain region at least in part by increasing the total amount of this enzyme.	Corticosterone	168-182	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	80-85
2537913-2	1989	ACTH-(11-24) stimulated the corticosterone production of zona fasciculata cells and the aldosterone production of zona glomerulosa cells; in addition, it potentiated the effects of ACTH-(1-39) on both cell systems.	Corticosterone	28-42	proopiomelanocortin	Homo sapiens	0-4
2470597-5	1989	This protective effect of ADX on hippocampal serotonergic neurons disappeared with concurrent administration of corticosterone (CORT) and MDMA administration.	Corticosterone	112-126	cortistatin	Homo sapiens	128-132
2466532-7	1989	These studies demonstrate that SP in vagal sensory neurons is more sensitive than CGRP to the effects of NGF or corticosterone.	Corticosterone	112-126	calcitonin-related polypeptide alpha	Rattus norvegicus	82-86
2695567-5	1989	Additionally, continuous daily treatment with interleukin-2 also induced increases in serum corticosterone but no detectable increases in serum IL1 or TNF.	Corticosterone	92-106	interleukin 2	Homo sapiens	46-59
2912130-5	1989	However, the steroid corticosterone induced a moderate increase in [125I] ANG II binding.	Corticosterone	21-35	angiotensinogen	Rattus norvegicus	74-80
2784766-6	1989	The decrease in TNF correlated with the appearance of significant amounts of endogenous serum corticosterone which were maximal by 3 h. Further evidence for the role of endogenous steroids in the modulation of serum TNF levels was obtained in studies with adrenalectomized or hypophysectomized mice.	Corticosterone	94-108	tumor necrosis factor	Mus musculus	16-19
2784766-6	1989	The decrease in TNF correlated with the appearance of significant amounts of endogenous serum corticosterone which were maximal by 3 h. Further evidence for the role of endogenous steroids in the modulation of serum TNF levels was obtained in studies with adrenalectomized or hypophysectomized mice.	Corticosterone	94-108	tumor necrosis factor	Mus musculus	216-219
2561946-5	1989	Since ACTH release is increased in adrenalectomized rats despite the down regulation of CRH-linked pituitary mechanisms, we speculate that the site of action of disinhibition by corticosterone of ACTH release (or synthesis) following adrenalectomy is distal to the generation of cyclic AMP and/or that non-CRH mediated mechanisms assume a greater role in ACTH regulation following adrenalectomy.	Corticosterone	178-192	corticotropin releasing hormone	Rattus norvegicus	88-91
2561946-5	1989	Since ACTH release is increased in adrenalectomized rats despite the down regulation of CRH-linked pituitary mechanisms, we speculate that the site of action of disinhibition by corticosterone of ACTH release (or synthesis) following adrenalectomy is distal to the generation of cyclic AMP and/or that non-CRH mediated mechanisms assume a greater role in ACTH regulation following adrenalectomy.	Corticosterone	178-192	corticotropin releasing hormone	Rattus norvegicus	306-309
2469985-1	1989	Corticosterone (CORT) induces responses in brain cells that are mediated by glucocorticoid receptors through regulation of gene activity.	Corticosterone	16-20	cortistatin	Rattus norvegicus	0-14
2546788-2	1989	An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS).	Corticosterone	120-134	interleukin 1 beta	Homo sapiens	50-59
2546788-2	1989	An intraperitoneal injection of recombinant human IL-1 beta (160 U/rat) significantly elevated serum levels of ACTH and corticosterone (CS).	Corticosterone	136-138	interleukin 1 beta	Homo sapiens	50-59
2816488-0	1989	Regulation of phenylethanolamine N-methyltransferase (PNMT) mRNA in the rat adrenal medulla by corticosterone.	Corticosterone	95-109	phenylethanolamine-N-methyltransferase	Rattus norvegicus	14-52
2816488-0	1989	Regulation of phenylethanolamine N-methyltransferase (PNMT) mRNA in the rat adrenal medulla by corticosterone.	Corticosterone	95-109	phenylethanolamine-N-methyltransferase	Rattus norvegicus	54-58
2816488-6	1989	Corticosterone replacement produced high prolonged plasma levels of corticosterone which were 10 times those of sham rats, and significantly increased levels of PNMT activity and mRNA.	Corticosterone	0-14	phenylethanolamine-N-methyltransferase	Rattus norvegicus	161-165
2816488-8	1989	These results suggest that the maintenance of PNMT mRNA levels is dependent on maintaining corticosterone levels and supports the hypothesis that PNMT gene expression in the adrenal medulla is directly regulated by glucocorticoids produced by the adrenal cortex.	Corticosterone	91-105	phenylethanolamine-N-methyltransferase	Rattus norvegicus	46-50
2576317-5	1989	Moreover, like typical antipsychotics, neurotensin and its analogue also increased serum concentrations of corticosterone.	Corticosterone	107-121	neurotensin	Homo sapiens	39-50
2549315-5	1989	Desacetyl-MSH and alpha-MSH both increased plasma corticosterone concentrations, but desacetyl-MSH was more potent.	Corticosterone	50-64	msh homeobox 1	Mus musculus	10-13
2549315-5	1989	Desacetyl-MSH and alpha-MSH both increased plasma corticosterone concentrations, but desacetyl-MSH was more potent.	Corticosterone	50-64	pro-opiomelanocortin-alpha	Mus musculus	18-27
2549315-5	1989	Desacetyl-MSH and alpha-MSH both increased plasma corticosterone concentrations, but desacetyl-MSH was more potent.	Corticosterone	50-64	msh homeobox 1	Mus musculus	24-27
2552244-6	1989	The diurnal elevation in plasma corticosterone continued after anti-CRH treatment, but peak levels occurred earlier.	Corticosterone	32-46	corticotropin releasing hormone	Rattus norvegicus	68-71
2741400-4	1989	At the same time, activation of glucose 6-phosphate dehydrogenase was accompanied by simultaneous alteration in content of transcortin-bound corticosterone in rat blood plasma.	Corticosterone	141-155	glucose-6-phosphate dehydrogenase	Rattus norvegicus	32-65
2741400-4	1989	At the same time, activation of glucose 6-phosphate dehydrogenase was accompanied by simultaneous alteration in content of transcortin-bound corticosterone in rat blood plasma.	Corticosterone	141-155	serpin family A member 6	Rattus norvegicus	123-134
3062144-5	1988	IL-1, TNF alpha and IL-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone.	Corticosterone	115-129	interleukin 1 alpha	Homo sapiens	0-4
3224284-0	1988	Neuropeptide Y, epinephrine and norepinephrine in the paraventricular nucleus: stimulation of feeding and the release of corticosterone, vasopressin and glucose.	Corticosterone	121-135	neuropeptide Y	Rattus norvegicus	0-14
3062144-5	1988	IL-1, TNF alpha and IL-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone.	Corticosterone	115-129	tumor necrosis factor	Homo sapiens	6-15
3062144-5	1988	IL-1, TNF alpha and IL-6 also affect changes in metabolism by changing levels of circulating insulin, glucagon and corticosterone.	Corticosterone	115-129	interleukin 6	Homo sapiens	20-24
2462133-2	1988	Treatment with alpha 2u-globulin for following 14 days of estrogen-treated rats reversed the effects of estrogen while in normal rats alpha 2u-globulin treatment increased adrenal 5-ene-3 beta-HSD activity and serum corticosterone level while causing a fall in serum ACTH.	Corticosterone	216-230	alpha2u globulin	Rattus norvegicus	15-32
2911602-7	1989	Our results suggest that angiotensin II may have a corticoid-dependent role in the regulation of corticotropin-releasing hormone secretion, which could be important in the adaptation to elevated corticosterone secretion in stress.	Corticosterone	195-209	angiotensinogen	Rattus norvegicus	25-39
2911602-7	1989	Our results suggest that angiotensin II may have a corticoid-dependent role in the regulation of corticotropin-releasing hormone secretion, which could be important in the adaptation to elevated corticosterone secretion in stress.	Corticosterone	195-209	corticotropin releasing hormone	Rattus norvegicus	97-128
2462133-2	1988	Treatment with alpha 2u-globulin for following 14 days of estrogen-treated rats reversed the effects of estrogen while in normal rats alpha 2u-globulin treatment increased adrenal 5-ene-3 beta-HSD activity and serum corticosterone level while causing a fall in serum ACTH.	Corticosterone	216-230	alpha2u globulin	Rattus norvegicus	134-151
2462133-3	1988	It is concluded that alpha 2u-globulin may play a role in ACTH secretion by inducing corticosterone synthesis.	Corticosterone	85-99	alpha2u globulin	Rattus norvegicus	21-38
3148796-5	1988	Testosterone, estriol, aldosterone and corticosterone provoked a significant inhibition of delta 5-desaturase in HTC cells.	Corticosterone	39-53	fatty acid desaturase 1	Rattus norvegicus	91-109
3205611-7	1988	As plasma concentrations of corticosteroid-binding globulin are known to increase markedly during this period, the t1/2 of protein-bound corticosterone was measured and that of free corticosterone was computed.	Corticosterone	137-151	serpin family A member 6	Rattus norvegicus	28-59
3209236-3	1988	Treatment with dexamethasone or corticosterone significantly inhibited both spontaneous and Con A-dependent induction of HDC and histamine biosynthesis.	Corticosterone	32-46	histidine decarboxylase	Mus musculus	121-124
2852828-7	1988	Plasma ACTH and corticosterone responses to exogenous CRH were not different between control and chronically immobilized rats, while the response to arginine vasopressin (AVP) was significantly greater in chronically immobilized rats.	Corticosterone	16-30	corticotropin releasing hormone	Rattus norvegicus	54-57
3264009-5	1988	In response to mitogen stimulation, however, splenocytes from athymic mice produced a factor (not IL-1), which, upon injection, increased corticosterone levels and suppressed inflammation.	Corticosterone	138-152	interleukin 1 complex	Mus musculus	98-102
3205611-11	1988	The increasing association of corticosterone with corticosteroid-binding globulin during this developmental period is the most likely explanation for the steep decline of volume of distribution and thus of the metabolic clearance rate for corticosterone.	Corticosterone	30-44	serpin family A member 6	Rattus norvegicus	50-81
3205611-11	1988	The increasing association of corticosterone with corticosteroid-binding globulin during this developmental period is the most likely explanation for the steep decline of volume of distribution and thus of the metabolic clearance rate for corticosterone.	Corticosterone	239-253	serpin family A member 6	Rattus norvegicus	50-81
2846407-7	1988	Infusions of exogenous, native ANG II at subpressor and pressor rates elicited dose-dependent increases in BP, which rose from a control mean of 22.6 +/- 5.8 mm Hg to a maximum mean value of 38.2 +/- 11.0 mm Hg (P less than 0.05 compared to control), and plasma corticosterone concentrations, which rose from a control mean of 6.6 +/- 2.8 ng/ml to a maximum mean value of 27.2 +/- 2.6 ng/ml (P less than 0.05 compared to control).	Corticosterone	262-276	angiotensinogen	Homo sapiens	31-37
2905986-2	1988	The effect of single injection of synthetic (dexamethasone 21-acetate) and natural (corticosterone) glucocorticoid on the depletion and replenishment of cytoplasmic glucocorticoid receptor in rat liver was compared.	Corticosterone	84-98	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	165-188
2850507-3	1988	Administration of an antiserum anti-rat corticotropin-releasing factor (CRF) to pregnant rats was followed by a significant decrease in fetal plasma corticosterone as early as day 17.	Corticosterone	149-163	corticotropin releasing hormone	Rattus norvegicus	40-70
3261749-0	1988	In vivo administration of IL-1 induces thymic hypoplasia and increased levels of serum corticosterone.	Corticosterone	87-101	interleukin 1 complex	Mus musculus	26-30
3261749-10	1988	injection of IL-1 caused a three-fold increase in serum corticosterone levels, which peaked approximately 3 h after IL-1 administration.	Corticosterone	56-70	interleukin 1 complex	Mus musculus	13-17
3261749-10	1988	injection of IL-1 caused a three-fold increase in serum corticosterone levels, which peaked approximately 3 h after IL-1 administration.	Corticosterone	56-70	interleukin 1 complex	Mus musculus	116-120
3261749-11	1988	Thus, an IL-1-dependent increase in serum corticosterone levels may be responsible for the observed thymic hypoplasia.	Corticosterone	42-56	interleukin 1 complex	Mus musculus	9-13
3411320-2	1988	At 6 h after corticosterone or dexamethasone administration, the specific activities of ornithine decarboxylase and N1-acetylspermidine transferase showed the greatest increases in all brain tissues examined, and at 12 h, S-adenosylmethionine decarboxylase activity was not increased significantly.	Corticosterone	13-27	ornithine decarboxylase 1	Rattus norvegicus	88-111
3411320-4	1988	Corticosterone and dexamethasone increased ornithine decarboxylase and N1-acetylspermidine transferase activities in a dose-dependent manner, with dexamethasone being more active than corticosterone in all tissues.	Corticosterone	0-14	ornithine decarboxylase 1	Rattus norvegicus	43-66
3411320-4	1988	Corticosterone and dexamethasone increased ornithine decarboxylase and N1-acetylspermidine transferase activities in a dose-dependent manner, with dexamethasone being more active than corticosterone in all tissues.	Corticosterone	184-198	ornithine decarboxylase 1	Rattus norvegicus	43-66
2843716-3	1988	Following infusion of 0.0084 microgram/kg of ACTH, plasma levels of corticosterone (P less than 0.02) and cortisol (P less than 0.01) were significantly increased; with chronic verapamil treatment plasma levels of corticosterone (P less than 0.05) and cortisol (P less than 0.02) were significantly lower than those without verapamil.	Corticosterone	68-82	proopiomelanocortin	Homo sapiens	45-49
2843716-3	1988	Following infusion of 0.0084 microgram/kg of ACTH, plasma levels of corticosterone (P less than 0.02) and cortisol (P less than 0.01) were significantly increased; with chronic verapamil treatment plasma levels of corticosterone (P less than 0.05) and cortisol (P less than 0.02) were significantly lower than those without verapamil.	Corticosterone	214-228	proopiomelanocortin	Homo sapiens	45-49
3420111-1	1988	The effect of exogenous corticosterone on the level of mouse hepatic glucocorticoid receptor was monitored to ascertain whether agonist-induced glucocorticoid receptor regulation takes place in living animals as it does in isolated cell systems.	Corticosterone	24-38	nuclear receptor subfamily 3, group C, member 1	Mus musculus	69-92
2855591-6	1988	Separate experiments showed that inhibitors of arachidonic acid release and metabolism (bromophenacyl bromide, nordihydroguaiaretic acid, caffeic acid or esculetin) blocked corticosterone production in fasciculata cells stimulated with ACTH, suggesting that arachidonic acid could be the common intermediate in the actions of AII and ACTH on steroid synthesis.	Corticosterone	173-187	angiotensinogen	Rattus norvegicus	326-329
2843187-1	1988	We report the purification, structure and biological properties of a peptide of novel sequence from human granulocytes that inhibits ACTH stimulated synthesis of corticosterone in rat adrenal cell suspensions.	Corticosterone	162-176	proopiomelanocortin	Homo sapiens	133-137
3064812-3	1988	Induction of the OvCAT genes by estrogen, progesterone, or corticosterone mimics that of the endogenous ovalbumin gene, indicating that the transfected DNA is accurately regulated.	Corticosterone	59-73	ovalbumin (SERPINB14)	Gallus gallus	104-113
2851747-3	1988	MSG-treated rats showed increased serum corticosterone (CORT) levels under resting conditions; after ether stress the increase in serum CORT was greater in MSG animals when compared to littermate controls.	Corticosterone	40-54	cortistatin	Rattus norvegicus	56-60
3211157-3	1988	Dexamethasone and, to a slightly lesser extent, corticosterone treatments reversed the adrenalectomy-induced increase in POMC mRNA concentrations in both anterior pituitary and hypothalamus.	Corticosterone	48-62	proopiomelanocortin	Rattus norvegicus	121-125
2852496-4	1988	Passive immunoneutralization of circulating corticotropin releasing factor (CRF) completely abolished ethanol-induced elevation in plasma corticosterone in LS mice.	Corticosterone	138-152	corticotropin releasing hormone	Mus musculus	44-74
2852496-5	1988	CRF or ACTH (adrenocorticotropin) produced dose-dependent elevations in plasma corticosterone in the two lines of mice.	Corticosterone	79-93	pro-opiomelanocortin-alpha	Mus musculus	7-11
3398525-10	1988	It is suggested that diabetic rat placentas showed increased activity towards the glucocorticoid receptor, resulting in reduction in progesterone synthesis and sustained catabolism of corticosterone.	Corticosterone	184-198	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	82-105
2855412-3	1988	After ACTH-stimulation, plasma levels of corticosterone were elevated in five obligate heterozygotes and 18-hydroxydeoxycorticosterone levels were increased in four of them.	Corticosterone	41-55	proopiomelanocortin	Homo sapiens	6-10
3401753-4	1988	Simultaneous infusion of submaximal doses of VIP (10(-5) M) and acetylcholine (5 X 10(-5) M) induced stimulations of corticosteroids (corticosterone and aldosterone) which were strictly additive.	Corticosterone	134-148	vasoactive intestinal peptide	Homo sapiens	45-48
2901357-1	1988	Intravenous administration of the 5-HT1B agonist, m-chlorophenylpiperazine (m-CPP) to rats produced increases in plasma prolactin (peak effect at 15 min), corticosterone (peak effect at 30 min) and a decrease in plasma growth hormone (peak effect at 15 min) concentrations.	Corticosterone	155-169	5-hydroxytryptamine receptor 1B	Rattus norvegicus	34-40
2835256-5	1988	Treatment with anti-AchR increased basal ACTH and corticosterone levels (by approximately twofold) but inhibited the response to acoustic stress.	Corticosterone	50-64	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	20-24
3261683-8	1988	The basal PNMT activity in SCG of adult rats was very low, but the treatment of rats with high dose of corticosterone or corticosterone replacement to adrenalectomized rats increased PNMT activity in the SCG to the same extent.	Corticosterone	103-117	phenylethanolamine-N-methyltransferase	Rattus norvegicus	10-14
3261683-0	1988	Effect of corticosterone treatment and adrenalectomy on phenylethanolamine N-methyltransferase and catecholamines in brain stem and hypothalamic nuclei and superior cervical ganglion of rats.	Corticosterone	10-24	phenylethanolamine-N-methyltransferase	Rattus norvegicus	56-94
3261683-1	1988	The effects of corticosterone treatment and adrenalectomy with or without corticosterone replacement on the activity of phenylethanolamine N-methyltransferase (PNMT) and catecholamine content has been studied in isolated brain stem nuclei containing adrenergic and noradrenergic nerve cell bodies, hypothalamic nuclei and in the superior cervical ganglion (SCG) of adult rats.	Corticosterone	15-29	phenylethanolamine-N-methyltransferase	Rattus norvegicus	120-158
3261683-1	1988	The effects of corticosterone treatment and adrenalectomy with or without corticosterone replacement on the activity of phenylethanolamine N-methyltransferase (PNMT) and catecholamine content has been studied in isolated brain stem nuclei containing adrenergic and noradrenergic nerve cell bodies, hypothalamic nuclei and in the superior cervical ganglion (SCG) of adult rats.	Corticosterone	15-29	phenylethanolamine-N-methyltransferase	Rattus norvegicus	160-164
3261683-1	1988	The effects of corticosterone treatment and adrenalectomy with or without corticosterone replacement on the activity of phenylethanolamine N-methyltransferase (PNMT) and catecholamine content has been studied in isolated brain stem nuclei containing adrenergic and noradrenergic nerve cell bodies, hypothalamic nuclei and in the superior cervical ganglion (SCG) of adult rats.	Corticosterone	74-88	phenylethanolamine-N-methyltransferase	Rattus norvegicus	120-158
3261683-1	1988	The effects of corticosterone treatment and adrenalectomy with or without corticosterone replacement on the activity of phenylethanolamine N-methyltransferase (PNMT) and catecholamine content has been studied in isolated brain stem nuclei containing adrenergic and noradrenergic nerve cell bodies, hypothalamic nuclei and in the superior cervical ganglion (SCG) of adult rats.	Corticosterone	74-88	phenylethanolamine-N-methyltransferase	Rattus norvegicus	160-164
3261683-4	1988	The treatment of rats with corticosterone resulted in a rise of PNMT activity only in C2 area.	Corticosterone	27-41	phenylethanolamine-N-methyltransferase	Rattus norvegicus	64-68
3261683-8	1988	The basal PNMT activity in SCG of adult rats was very low, but the treatment of rats with high dose of corticosterone or corticosterone replacement to adrenalectomized rats increased PNMT activity in the SCG to the same extent.	Corticosterone	103-117	phenylethanolamine-N-methyltransferase	Rattus norvegicus	183-187
3261683-8	1988	The basal PNMT activity in SCG of adult rats was very low, but the treatment of rats with high dose of corticosterone or corticosterone replacement to adrenalectomized rats increased PNMT activity in the SCG to the same extent.	Corticosterone	121-135	phenylethanolamine-N-methyltransferase	Rattus norvegicus	10-14
3261683-8	1988	The basal PNMT activity in SCG of adult rats was very low, but the treatment of rats with high dose of corticosterone or corticosterone replacement to adrenalectomized rats increased PNMT activity in the SCG to the same extent.	Corticosterone	121-135	phenylethanolamine-N-methyltransferase	Rattus norvegicus	183-187
3216900-5	1988	Only in young rats did the administration of corticosterone (1 mg/kg, 30 min) reduced GABA levels in the corpus striatum (34%).	Corticosterone	45-59	4-aminobutyrate aminotransferase	Rattus norvegicus	86-90
3216900-6	1988	In young rats this dose of corticosterone: 1. did not affect the activity of the enzymes of the metabolism of GABA (GAD and GABA-T); 2. reduced neuronal 3H-GABA uptake in the corpus striatum (30%) and in the mediobasal hypothalamus (46%), and increased it in the frontal cortex (2-fold); 3. enhanced the turnover of GABA (2-fold) in the corpus striatum.	Corticosterone	27-41	4-aminobutyrate aminotransferase	Rattus norvegicus	124-130
3401709-10	1988	Corticosterone injection in hypophysectomized rats produced a response similar to that caused by saline injection in intact animals: NAT activity was depressed at 10 min and melatonin content was lowered at 25 min.	Corticosterone	0-14	N-acetyltransferase 1	Rattus norvegicus	133-136
3259079-0	1988	Circulating osteocalcin in rats is inversely responsive to changes in corticosterone.	Corticosterone	70-84	bone gamma-carboxyglutamate protein	Rattus norvegicus	12-23
3259079-3	1988	Exogenous steroid elicited a time- and dose-related decrease in serum osteocalcin, which was significant within 1 h of administration and maximally 25% below controls 1.5 h after injection of 3.3 mg corticosterone/kg body wt, the highest dose we tested.	Corticosterone	199-213	bone gamma-carboxyglutamate protein	Rattus norvegicus	70-81
3259079-5	1988	Exposure to environmental stressors lasting from 1.5 h to 3 wk also resulted in decreased osteocalcin levels, which showed a strong negative correlation (P less than 0.001) with serum corticosterone levels and adrenal mass after 1-3 wk of chronic cold exposure.	Corticosterone	184-198	bone gamma-carboxyglutamate protein	Rattus norvegicus	90-101
3359977-7	1988	VIP (10(-6)-10(-4) M) stimulated dose-dependent increases in both aldosterone (1.7- to 41.0-fold) and corticosterone secretion (1.8- to 5.3-fold).	Corticosterone	102-116	vasoactive intestinal peptide	Rattus norvegicus	0-3
2901112-9	1988	It is concluded that buspirone, gepirone and ipsapirone produce hypothermia and increase plasma concentrations of corticosterone by activating 5-HT1A receptor mechanisms.	Corticosterone	114-128	5-hydroxytryptamine receptor 1A	Rattus norvegicus	143-149
3413197-0	1988	Influence of exogenously administered oxytocin on the corticosterone and prolactin response to psychological stress.	Corticosterone	54-68	oxytocin/neurophysin I prepropeptide	Homo sapiens	38-46
3413197-3	1988	The present study was therefore designed to examine the possible role of oxytocin in the corticosterone and prolactin response to predictable and unpredictable novelty stress.	Corticosterone	89-103	oxytocin/neurophysin I prepropeptide	Homo sapiens	73-81
3413197-4	1988	Repeated stress and oxytocin treatment produced a substantial increase in corticosterone.	Corticosterone	74-88	oxytocin/neurophysin I prepropeptide	Homo sapiens	20-28
3413197-6	1988	In addition, for the smaller oxytocin dose only, unpredictable exposure to the novelty apparatus produced a more substantial increase in corticosterone than predictable exposure to the same stressor.	Corticosterone	137-151	oxytocin/neurophysin I prepropeptide	Homo sapiens	29-37
3413197-9	1988	It was concluded that an important role exists for oxytocin in the modulation of both corticosterone and prolactin secretion.	Corticosterone	86-100	oxytocin/neurophysin I prepropeptide	Homo sapiens	51-59
2895160-6	1988	Responses to K+ depolarization were Ca2+-dependent, and the addition of corticosterone (100 nmol/l) to the defined medium caused a significant reduction in the response of neurones secreting CRF-41 and AVP, but not those secreting SRIF, to depolarization.	Corticosterone	72-86	arginine vasopressin	Rattus norvegicus	202-205
3131280-1	1988	The cytotoxic activity of tumor necrosis factor (TNF) against L929 fibroblasts in vivo was noncompetitively inhibited by physiological concentrations of glucocorticoids such as hydrocortisone (10(-7) M), corticosterone (5 X 10(-8) M) and dexamethasone (5 X 10(-9) M).	Corticosterone	204-218	tumor necrosis factor	Homo sapiens	26-47
3131280-1	1988	The cytotoxic activity of tumor necrosis factor (TNF) against L929 fibroblasts in vivo was noncompetitively inhibited by physiological concentrations of glucocorticoids such as hydrocortisone (10(-7) M), corticosterone (5 X 10(-8) M) and dexamethasone (5 X 10(-9) M).	Corticosterone	204-218	tumor necrosis factor	Homo sapiens	49-52
3398855-2	1988	To investigate genomic responses in brain to stress levels of circulating corticosterone (CORT), we isolated hippocampal total RNA and poly(A)-containing RNA from rats treated with 10 mg/day CORT or vehicle.	Corticosterone	74-88	cortistatin	Rattus norvegicus	90-94
3394170-0	1988	[Effect of transcortin on the corticosterone-transforming activity of cytosol from the rat liver].	Corticosterone	30-44	serpin family A member 6	Rattus norvegicus	11-22
3394170-3	1988	Under the influence of homogeneous transcortin samples, a decrease in the content of 5 beta-reduced corticosterone metabolites is revealed to occur depending on transcortin concentration in the system.	Corticosterone	100-114	serpin family A member 6	Rattus norvegicus	35-46
3394170-3	1988	Under the influence of homogeneous transcortin samples, a decrease in the content of 5 beta-reduced corticosterone metabolites is revealed to occur depending on transcortin concentration in the system.	Corticosterone	100-114	serpin family A member 6	Rattus norvegicus	161-172
3394170-5	1988	The transcortin activity on corticosterone metabolism is supposed to be closely related to the intensity of its complexing with transcortin.	Corticosterone	28-42	serpin family A member 6	Rattus norvegicus	4-15
3394170-5	1988	The transcortin activity on corticosterone metabolism is supposed to be closely related to the intensity of its complexing with transcortin.	Corticosterone	28-42	serpin family A member 6	Rattus norvegicus	128-139
3224522-4	1988	Treatment with the same respective doses of rbGH in the presence of 1 ppm corticosterone, supplied to suppress any possible immune response elicited by the heterologous somatotropin, resulted in an 8.0% and 7.8% increase (P less than .05) in growth rate during the first week of treatment.	Corticosterone	74-88	somatotropin	Bos taurus	169-181
2839961-3	1988	Histamine, 2-pyridylethylamine (PEA), a histamine H1-receptor agonist, and 4-methyl-histamine (MeHA) and dimaprit, the H2-receptor agonists, considerably increased the serum corticosterone levels 1 h after administration.	Corticosterone	174-188	histamine receptor H 1	Rattus norvegicus	40-61
2828010-6	1988	In a pharmacological approach, we measured the influence of the complete, competitive antagonist, human (h) ACTH-(7-38) on hACTH-(7-39)-induced corticosterone production by adrenocortical cells from L and N cockerels.	Corticosterone	144-158	proopiomelanocortin	Homo sapiens	108-112
2832501-10	1988	ACTH did not augment mitotic activity in enucleated-hypophysectomized rats but significantly increased plasma concentrations of corticosterone in s.c. injection experiments.	Corticosterone	128-142	proopiomelanocortin	Homo sapiens	0-4
2895158-4	1988	Anti-SRIF stimulated a much greater increase in plasma corticosterone concentrations and a peak response was observed within 10 to 20 min, when the plasma corticosterone level reached more than twice that of the corresponding control value.	Corticosterone	55-69	somatostatin	Ovis aries	5-9
2895158-4	1988	Anti-SRIF stimulated a much greater increase in plasma corticosterone concentrations and a peak response was observed within 10 to 20 min, when the plasma corticosterone level reached more than twice that of the corresponding control value.	Corticosterone	155-169	somatostatin	Ovis aries	5-9
2895158-5	1988	With less frequent sampling, plasma corticosterone increased with anti-SRIF administration to as much as nine times the corresponding control value, and the peak response occurred much later.	Corticosterone	36-50	somatostatin	Ovis aries	71-75
2895158-6	1988	Under pentobarbitone anaesthesia, which itself increased basal corticosterone concentrations, anti-SRIF treatment promoted further increases in plasma corticosterone levels although to a smaller magnitude compared with conscious birds.	Corticosterone	63-77	somatostatin	Ovis aries	99-103
2895158-6	1988	Under pentobarbitone anaesthesia, which itself increased basal corticosterone concentrations, anti-SRIF treatment promoted further increases in plasma corticosterone levels although to a smaller magnitude compared with conscious birds.	Corticosterone	151-165	somatostatin	Ovis aries	99-103
2837755-11	1988	Donor CS was significantly lower in birds that received ACTH.	Corticosterone	6-8	proopiomelanocortin	Homo sapiens	56-60
3344832-1	1988	Food intake, body weight, and meal patterns in rats are known to be specifically influenced by circulating corticosterone (CORT).	Corticosterone	107-121	cortistatin	Rattus norvegicus	123-127
2837755-12	1988	These results indicate that, when washed and reconstituted blood cells are injected into recipients and donor plasma CS is decreased, GVHR capacity is suppressed in ACTH-treated donors.	Corticosterone	117-119	proopiomelanocortin	Homo sapiens	165-169
3291665-14	1988	CCK-8 exhibits short-term cross-tolerance with ACTH in elicitation of grooming, and central CCK-8 is co-localized with CRF and stimulates ACTH and corticosterone release in the rat.	Corticosterone	147-161	cholecystokinin	Rattus norvegicus	92-95
2826112-9	1988	Plasma immunoreactive ACTH and corticosterone levels were decreased in the group treated with anti-hACTH (P less than 0.0001 and P less than 0.01, respectively).	Corticosterone	31-45	proopiomelanocortin	Homo sapiens	99-104
3386271-4	1988	However, the sequestering influence of transcortin on receptor binding of corticosterone could be demonstrated by the FPLC technique with mixtures containing serum and hippocampus cytosol.	Corticosterone	74-88	serpin family A member 6	Rattus norvegicus	39-50
2892695-2	1988	Rat adrenocortical carcinoma cells possess a high density of atrial natriuretic factor (ANF) receptors which are coupled with membrane guanylate cyclase and corticosterone production.	Corticosterone	157-171	natriuretic peptide A	Rattus norvegicus	61-86
2892695-2	1988	Rat adrenocortical carcinoma cells possess a high density of atrial natriuretic factor (ANF) receptors which are coupled with membrane guanylate cyclase and corticosterone production.	Corticosterone	157-171	natriuretic peptide A	Rattus norvegicus	88-91
3260987-0	1988	Systemic interleukin-1 administration stimulates hypothalamic norepinephrine metabolism parallelling the increased plasma corticosterone.	Corticosterone	122-136	interleukin 1 complex	Mus musculus	9-22
3351363-5	1988	It has been known that adrenal secretion of corticosterone in response to exogenous ACTH occurs prior to that of cortisol.	Corticosterone	44-58	proopiomelanocortin	Homo sapiens	84-88
3258984-2	1988	The purpose of this study was to determine the influence of the brain-gut polypeptides CCK33 (10 U/kg), bombesin (10 micrograms/kg) and secretin (10 U/kg) on corticosterone concentrations in fed rats.	Corticosterone	158-172	secretin	Rattus norvegicus	136-144
3319051-6	1987	At that time, 1 h after administration to longterm ADX rats the synthetic glucocorticoid (type 2) agonist RU 28362 as well as a moderate and high dose of corticosterone (CORT) markedly enhanced the cell nuclear GR-ir.	Corticosterone	154-168	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	211-213
3690353-1	1987	In vivo brain uptake of labeled aldosterone (ALD) and corticosterone (CORT) in adrenalectomized (ADX) rats indicates a strong cell-nuclear localization of both hormones, predominantly in the hippocampus.	Corticosterone	54-68	cortistatin	Rattus norvegicus	70-74
2892145-8	1987	The CS release evoked by morphine, D-Met-Pro-Enk, Met-Enk and DYN was demonstrable only in the morning when the basal CS level was significantly lower than in the afternoon.	Corticosterone	4-6	proenkephalin	Rattus norvegicus	45-48
2892145-8	1987	The CS release evoked by morphine, D-Met-Pro-Enk, Met-Enk and DYN was demonstrable only in the morning when the basal CS level was significantly lower than in the afternoon.	Corticosterone	4-6	proenkephalin	Rattus norvegicus	54-57
2892145-8	1987	The CS release evoked by morphine, D-Met-Pro-Enk, Met-Enk and DYN was demonstrable only in the morning when the basal CS level was significantly lower than in the afternoon.	Corticosterone	118-120	proenkephalin	Rattus norvegicus	45-48
2892145-8	1987	The CS release evoked by morphine, D-Met-Pro-Enk, Met-Enk and DYN was demonstrable only in the morning when the basal CS level was significantly lower than in the afternoon.	Corticosterone	118-120	proenkephalin	Rattus norvegicus	54-57
3318508-6	1987	A moderate hypoglycemia, paralleled by increased glucagon and corticosterone blood levels, was also observed in IL 1-injected rats, but no increase in insulin levels was detected.	Corticosterone	62-76	interleukin 1 complex	Mus musculus	112-116
3431658-1	1987	Modulation of CA1 electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of corticosterone (CT) was studied in hippocampal slice preparations from normal (sham) and adrenalectomized (ADX) BALB/c mice.	Corticosterone	129-143	carbonic anhydrase 1	Mus musculus	14-17
3431658-1	1987	Modulation of CA1 electrophysiological properties (amplitude, latency, paired-pulse facilitation) by different concentrations of corticosterone (CT) was studied in hippocampal slice preparations from normal (sham) and adrenalectomized (ADX) BALB/c mice.	Corticosterone	145-147	carbonic anhydrase 1	Mus musculus	14-17
2443979-1	1987	Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH).	Corticosterone	110-124	interleukin 1 alpha	Homo sapiens	52-65
2894798-1	1987	Ornithine decarboxylase activity of rat lung was induced by s.c. injection of acetylcholine, norepinephrine, epinephrine, dopamine, serotonin, vasopressin, angiotensin II, and adrenocorticotropic hormone, but not by gonadotropin, aldosterone, corticosterone or hydrocortisone.	Corticosterone	243-257	ornithine decarboxylase 1	Rattus norvegicus	0-23
3661059-8	1987	PRL administration affected also the correlations between the diurnal changes in plasma corticosterone concentration and those in lymphocyte number and anti-sheep red blood cells agglutinin titre.	Corticosterone	88-102	prolactin	Gallus gallus	0-3
3661059-9	1987	This suggests that the role of PRL in the regulation of the diurnal variations of immunity in chickens may be realized either directly, via its receptors in immune system or by its influence on plasma corticosterone concentration.	Corticosterone	201-215	prolactin	Gallus gallus	31-34
2443979-1	1987	Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH).	Corticosterone	110-124	interleukin 1 alpha	Homo sapiens	67-71
2830101-0	1987	The influence of transcortin on adrenocorticotropin-stimulated corticosterone production in monolayer cultured rat adrenal cells.	Corticosterone	63-77	serpin family A member 6	Rattus norvegicus	17-28
2826568-10	1987	In addition to these effects on short-term regulators of glycemia, intracisternal beta-endorphin increased plasma concentrations of corticosterone and growth hormone.	Corticosterone	132-146	proopiomelanocortin	Homo sapiens	82-96
2988711-6	1985	We speculate that the blockade is due to a partial elimination of CRF and/or vasopressin/oxytocinergic pathways which are activated by the fall in plasma corticosterone after removal of an adrenal gland.	Corticosterone	154-168	arginine vasopressin	Rattus norvegicus	77-88
3882412-13	1985	The physiologically relevent adrenal corticoids, corticosterone and aldosterone, only potentiate the stimulatory effect of PRL.	Corticosterone	49-63	prolactin	Mus musculus	123-126
4015847-0	1985	Ethanol increases rat liver tryptophan oxygenase: evidence for corticosterone mediation.	Corticosterone	63-77	tryptophan 2,3-dioxygenase	Rattus norvegicus	28-48
4015847-6	1985	Ethanol administration increased the concentration of plasma corticosterone sufficiently to increase TO activity.	Corticosterone	61-75	tryptophan 2,3-dioxygenase	Rattus norvegicus	101-103
4015847-8	1985	The increased TO activities found after ethanol or corticosterone treatment were influenced in the same manner and to the same extent by cycloheximide.	Corticosterone	51-65	tryptophan 2,3-dioxygenase	Rattus norvegicus	14-16
3479194-2	1987	If rats after CRG injections were exposed to immobilization stress, the level of corticosterone in the adrenal cortex and blood plasma was not increased, like in the control groups of rats not receiving CRG.	Corticosterone	81-95	serpin family E member 2	Rattus norvegicus	14-17
3499151-6	1987	Addition of growth hormone to the combination of corticosterone, dihydrotestosterone, and thyroxine increased serum elastase inhibitory capacity and alpha 1-antitrypsin mRNA.	Corticosterone	49-63	gonadotropin releasing hormone receptor	Rattus norvegicus	12-26
3499151-6	1987	Addition of growth hormone to the combination of corticosterone, dihydrotestosterone, and thyroxine increased serum elastase inhibitory capacity and alpha 1-antitrypsin mRNA.	Corticosterone	49-63	serpin family A member 1	Homo sapiens	149-168
3040377-0	1987	Plasma adrenocorticotropin is more sensitive than transcortin production or thymus weight to inhibition by corticosterone in rats.	Corticosterone	107-121	serpin family A member 6	Rattus norvegicus	50-61
3312463-0	1987	Disparate effects of ACTH (1-24) and corticosterone on lipoprotein lipase in rat adipose tissue.	Corticosterone	37-51	lipoprotein lipase	Rattus norvegicus	55-73
3312463-5	1987	Corticosterone and ACTH(1-24) treatment had a similar effect on LPL activity in adrenalectomized and intact rats.	Corticosterone	0-14	lipoprotein lipase	Rattus norvegicus	64-67
3040926-2	1987	This effect is reversed by replacement with glucocorticoids such as dexamethasone (DEX) and corticosterone (CORT).	Corticosterone	92-106	cortistatin	Rattus norvegicus	108-112
2822506-4	1987	In the obese, adrenalectomy completely abolished the response of cyclase to ACTH and in the lean, corticosterone supplementation augmented the ACTH response.	Corticosterone	98-112	pro-opiomelanocortin-alpha	Mus musculus	143-147
3039518-8	1987	In another experiment, markedly greater changes, at similar time intervals, in plasma corticosterone were effected by multiple subcutaneous injections of adrenocorticotropic hormone (ACTH) (either 5 IU ACTH or 20 IU ACTH/kg).	Corticosterone	86-100	proopiomelanocortin	Homo sapiens	154-181
3039518-8	1987	In another experiment, markedly greater changes, at similar time intervals, in plasma corticosterone were effected by multiple subcutaneous injections of adrenocorticotropic hormone (ACTH) (either 5 IU ACTH or 20 IU ACTH/kg).	Corticosterone	86-100	proopiomelanocortin	Homo sapiens	183-187
3040184-4	1987	We therefore microinjected NPY into the area of the PVN of both conscious, freely moving and anaesthetized rats and noted a powerful stimulatory effect on adrenocorticotropic hormone (ACTH) and corticosterone release as measured by radioimmunoassay.	Corticosterone	194-208	neuropeptide Y	Rattus norvegicus	27-30
3040184-5	1987	In experiments with conscious, freely moving rats, higher ACTH and corticosterone levels were detected following injection of NPY into the area of the PVN than following control injection (desamidated NPY).	Corticosterone	67-81	neuropeptide Y	Rattus norvegicus	126-129
3040184-6	1987	Intracerebroventricular injection of NPY produced a small, albeit significant, increase in circulating corticosterone levels as compared to control (saline-injected) rats.	Corticosterone	103-117	neuropeptide Y	Rattus norvegicus	37-40
3040184-7	1987	Anaesthetized rats responded to NPY (but not to saline) injected into the area of the PVN with elevated ACTH and corticosterone levels, while injection of NPY into the neocortex failed to affect the blood concentration of either ACTH or corticosterone.	Corticosterone	113-127	neuropeptide Y	Rattus norvegicus	32-35
3497458-2	1987	This study asked three questions: Does IL-1 increase the corticosterone levels of rat serum?	Corticosterone	57-71	interleukin 1 alpha	Homo sapiens	39-43
3497458-5	1987	The intraperitoneal injection of IL-1 (70 micrograms) in anesthetized male Fisher rats resulted in elevated corticosterone levels at 30 minutes and reached a maximum at 180 minutes (94 +/- 12 versus 34 +/- 4 micrograms/dl, p less than 0.01).	Corticosterone	108-122	interleukin 1 alpha	Homo sapiens	33-37
3497458-7	1987	Corticosterone secretion was significantly increased (p less than 0.01) 90 minutes after a single arterial bolus of 35 micrograms of IL-1.	Corticosterone	0-14	interleukin 1 alpha	Homo sapiens	133-137
3497458-10	1987	This study demonstrates that IL-1 increases rat serum corticosterone levels, IL-1 directly stimulates the adrenal cortex, and the stimulation may be mediated through prostaglandin synthesis.	Corticosterone	54-68	interleukin 1 alpha	Homo sapiens	29-33
3611064-4	1987	In the presence of either dexamethasone or corticosterone, secreted plasma fibronectin increased maximally to 2.8-fold above basal levels.	Corticosterone	43-57	fibronectin 1	Gallus gallus	75-86
2824246-0	1987	[Stimulated corticosterone production by alpha-human atrial natriuretic polypeptide with increased cyclic GMP production].	Corticosterone	12-26	5'-nucleotidase, cytosolic II	Homo sapiens	106-109
3620909-6	1987	Explanted medullae required medium supplemented with dexamethasone or corticosterone to achieve maximal levels of Leu-enkephalin in a dose-dependent fashion.	Corticosterone	70-84	prodynorphin	Homo sapiens	114-128
3495595-2	1987	alpha-MSH administration was also capable of inhibiting the capacity of i.v.-administered IL 1 beta to enhance plasma levels of corticosterone and to depress the generation and/or elicitation of contact hypersensitivity responses to skin-reactive chemicals.	Corticosterone	128-142	pro-opiomelanocortin-alpha	Mus musculus	0-9
3495595-2	1987	alpha-MSH administration was also capable of inhibiting the capacity of i.v.-administered IL 1 beta to enhance plasma levels of corticosterone and to depress the generation and/or elicitation of contact hypersensitivity responses to skin-reactive chemicals.	Corticosterone	128-142	interleukin 1 beta	Mus musculus	90-99
3330674-2	1987	The high level of mortality following injection of LPS that is noted in adrenalectomized rats can be reversed by dexamethasone or corticosterone.	Corticosterone	130-144	toll-like receptor 4	Mus musculus	51-54
3330674-3	1987	That histamine may be an endogenous mediator of the release of corticosterone caused by LPS is suggested by an attenuation of this corticosterone response by promethazine, an H1 antihistamine.	Corticosterone	63-77	toll-like receptor 4	Mus musculus	88-91
3330674-3	1987	That histamine may be an endogenous mediator of the release of corticosterone caused by LPS is suggested by an attenuation of this corticosterone response by promethazine, an H1 antihistamine.	Corticosterone	131-145	toll-like receptor 4	Mus musculus	88-91
3330674-4	1987	Additional support that LPS-dependent glucocorticoid secretion is mediated, in part, by histamine, is suggested by spleen cell transfer studies revealing differences in the induction of histidine decarboxylase (HDC) synthesis and corticosterone release by the C3H/HeN and C3H/HeJ strains of mice that are differentially sensitive to LPS effects.	Corticosterone	230-244	toll-like receptor 4	Mus musculus	24-27
3552636-4	1987	Corticosterone (12.4-150 nM) was toxic to the Nb2-11C cells.	Corticosterone	0-14	contactin 5	Rattus norvegicus	46-49
2440970-3	1987	Methylisobutylxanthine added during the first 2 days after confluence, added with insulin and corticosterone, potentiates the effect of insulin on GPDH activity and accelerates triglyceride accumulation.	Corticosterone	94-108	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	147-151
2956114-3	1987	The corticosterone and beta-END responses to 8-OH-DPAT were antagonized by spiperone and (-)-pindolol, both of which have been shown to have high affinity for the 5-HT1A binding site.	Corticosterone	4-18	5-hydroxytryptamine receptor 1A	Rattus norvegicus	163-169
3599649-0	1987	Polycystic kidney and liver disease and corticosterone changes in the cpk mouse.	Corticosterone	40-54	cystin 1	Mus musculus	70-73
3599649-1	1987	Mice homozygous for the mutation cpk develop a lethal infantile polycystic kidney disease (PKD) and have abnormal elevations of corticosterone in the postnatal period.	Corticosterone	128-142	cystin 1	Mus musculus	33-36
3599649-5	1987	Corticosterone levels were significantly higher in all homozygote (cpk/cpk) and some of the normal sibs, who were presumed to be heterozygote (cpk/+) mice compared to age-matched controls from day seven to 12.	Corticosterone	0-14	cystin 1	Mus musculus	67-70
3599649-5	1987	Corticosterone levels were significantly higher in all homozygote (cpk/cpk) and some of the normal sibs, who were presumed to be heterozygote (cpk/+) mice compared to age-matched controls from day seven to 12.	Corticosterone	0-14	cystin 1	Mus musculus	71-74
3599649-5	1987	Corticosterone levels were significantly higher in all homozygote (cpk/cpk) and some of the normal sibs, who were presumed to be heterozygote (cpk/+) mice compared to age-matched controls from day seven to 12.	Corticosterone	0-14	cystin 1	Mus musculus	71-74
3036625-3	1987	The capacity to convert corticosterone to aldosterone is also reduced by a prior exposure to AII.	Corticosterone	24-38	angiotensinogen	Rattus norvegicus	93-96
2886358-3	1987	The stress induced serum corticosterone increase is not correlated with the described changes, however, in non-stressed animals an increased TAT activity at 3 and 8 h after progesterone injection tightly follows the increased plasma corticosterone values.	Corticosterone	25-39	tyrosine aminotransferase	Rattus norvegicus	141-144
2886358-3	1987	The stress induced serum corticosterone increase is not correlated with the described changes, however, in non-stressed animals an increased TAT activity at 3 and 8 h after progesterone injection tightly follows the increased plasma corticosterone values.	Corticosterone	233-247	tyrosine aminotransferase	Rattus norvegicus	141-144
2952898-0	1987	Differential effects of serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion.	Corticosterone	91-105	5-hydroxytryptamine receptor 1A	Homo sapiens	35-41
2952898-1	1987	The present study was designed to investigate the effect of distinct serotonin (5-HT1A and 5-HT2) agonists and antagonists on renin and corticosterone secretion.	Corticosterone	136-150	5-hydroxytryptamine receptor 1A	Homo sapiens	80-86
3583909-3	1987	Corticosterone treatment significantly depressed serum prolactin and testosterone but gonadotropins were unaltered.	Corticosterone	0-14	prolactin	Rattus norvegicus	55-64
3030124-5	1987	Studies in 10-day-old rats, with very low levels of corticosteroid binding globulin (CBG), showed a high degree of aldosterone selectivity in both zones of the kidney, whereas [3H]aldosterone and [3H]corticosterone were equivalently bound in hippocampus.	Corticosterone	200-214	serpin family A member 6	Rattus norvegicus	85-88
2822295-4	1987	Corticosterone, 18-hydroxycorticosterone and aldosterone concentrations were abnormally sensitive to infusions of ACTH and angiotensin II.	Corticosterone	0-14	proopiomelanocortin	Homo sapiens	114-137
3819638-6	1987	Daily injections of 2500 micrograms corticosterone/kg body weight, in both lines, depressed mean concentrations of plasma prolactin, T3 and somatomedin C and body weight.	Corticosterone	36-50	prolactin	Homo sapiens	122-131
3819638-6	1987	Daily injections of 2500 micrograms corticosterone/kg body weight, in both lines, depressed mean concentrations of plasma prolactin, T3 and somatomedin C and body weight.	Corticosterone	36-50	insulin like growth factor 1	Homo sapiens	140-153
3824389-6	1987	This temporal sequence of hormonal changes suggests that the earlier alteration in PRL may be involved in the later alterations in the concentrations of serum T4 and corticosterone.	Corticosterone	166-180	prolactin	Rattus norvegicus	83-86
20928962-2	1987	Major hormonal responses to surgery, as indicated by changes in plasma adrenaline, noradrenaline, glucagon, aldosterone, corticosterone, 11-deoxycorticosterone, and 11-deoxycortisol levels, in the insulin/glucagon, molar ratio, and in blood glucose, lactate, and pyruvate concentrations were significantly greater in the non-fentanyl than in the fentanyl group.	Corticosterone	121-135	insulin	Homo sapiens	197-204
3593199-3	1987	The steroid specificity of this effect was investigated and various steroids were found to inhibit calcitriol-stimulated PRL production with the following relative potencies: cortisol, 1; dexamethasone, 8; 11-deoxycortisol, 0.5; corticosterone, 0.4; aldosterone, 0.07; testosterone and oestradiol, less than 0.003.	Corticosterone	229-243	prolactin	Rattus norvegicus	121-124
2879174-2	1987	Major hormonal responses to surgery, as indicated by changes in plasma adrenaline, noradrenaline, glucagon, aldosterone, corticosterone, 11-deoxycorticosterone, and 11-deoxycortisol levels, in the insulin/glucagon, molar ratio, and in blood glucose, lactate, and pyruvate concentrations were significantly greater in the non-fentanyl than in the fentanyl group.	Corticosterone	121-135	insulin	Homo sapiens	197-204
3028026-1	1987	To test the hypothesis that the trophic action of angiotensin II on the adrenal zona glomerulosa may allow a sustained stimulation of aldosterone by ACTH by preventing the morphological changes of the zona glomerulosa cells into zona fasciculata-like elements we investigated the effects in rats of a 6-day treatment with ACTH (100 micrograms/kg/day) alone or combined with angiotensin II (300 ng/kg/day) on corticosterone and aldosterone production and adrenal morphology.	Corticosterone	408-422	angiotensinogen	Rattus norvegicus	50-64
2829507-9	1987	e) Central NPY administration leads to alterations in serum levels of corticosterone, aldosterone, angiotensin II, vasopressin, PRL, LH, GH and TSH which are parallel to changes in discrete hypothalamic catecholamine neuronal systems.	Corticosterone	70-84	neuropeptide Y	Homo sapiens	11-14
2880509-6	1987	The increase in glutamine synthetase activity in wounded muscle was prevented by adrenalectomy and restored by replacement doses of corticosterone in wounded adrenalectomized animals.	Corticosterone	132-146	glutamate-ammonia ligase	Rattus norvegicus	16-36
3551808-7	1987	In vivo studies, in contrast, show that corticosterone is very poorly taken up and/or retained in kidney, colon, parotid, and pituitary (but not in hippocampus) in mature and 10-day-old (minimal transcortin) rats, whereas aldosterone is well taken up and/or retained by all tissues, evidence for tissue-specific aldosterone selectivity in vivo.	Corticosterone	40-54	serpin family A member 6	Rattus norvegicus	195-206
2830068-3	1987	Basal, and maximum AII-, ACTH-, and potassium-stimulated levels of corticosterone, 18-OHB and aldosterone also were similar in the cells from SHR and WKY.	Corticosterone	67-81	angiotensinogen	Homo sapiens	19-22
2889565-7	1987	oPRL, in the presence or absence of ACTH, raised corticosterone production of hypox rat cells, but not intact rat and domestic fowl cells.	Corticosterone	49-63	opioid related nociceptin receptor 1	Rattus norvegicus	0-4
2889565-9	1987	In addition, oPRL counteracted the corticosterone-induced suppression of net ACTH-stimulated corticosterone production of hypox rat and intact domestic fowl cells, but not intact rat cells.	Corticosterone	35-49	opioid related nociceptin receptor 1	Rattus norvegicus	13-17
2889565-9	1987	In addition, oPRL counteracted the corticosterone-induced suppression of net ACTH-stimulated corticosterone production of hypox rat and intact domestic fowl cells, but not intact rat cells.	Corticosterone	93-107	opioid related nociceptin receptor 1	Rattus norvegicus	13-17
3023030-6	1987	With higher AII doses (50 and 100 ng/min), which increased plasma corticosterone (and presumably ACTH secretion), the inhibitory effect of ANF was less marked.	Corticosterone	66-80	angiotensinogen	Rattus norvegicus	12-15
3323142-7	1987	Immunocytochemical double labelling studies performed on adrenalectomized plus corticosterone-replaced animals demonstrated glucocorticoid receptor-IR sites in the cell nuclei of parvocellular paraventricular neurons that expressed CRF-immunoreactivity in their cytoplasm.	Corticosterone	79-93	nuclear receptor subfamily 3 group C member 1	Homo sapiens	124-147
3029259-8	1987	The results are discussed in the light of a possible specific corticosteroid-binding globulin (CBG) like binding protein of adrenal origin released in conjunction with corticosterone.	Corticosterone	168-182	serpin family A member 6	Rattus norvegicus	62-93
3029259-8	1987	The results are discussed in the light of a possible specific corticosteroid-binding globulin (CBG) like binding protein of adrenal origin released in conjunction with corticosterone.	Corticosterone	168-182	serpin family A member 6	Rattus norvegicus	95-98
3029259-9	1987	This binding protein has a lower affinity for corticosterone and a shorter half-life than CBG.	Corticosterone	46-60	serpin family A member 6	Rattus norvegicus	90-93
2824799-2	1987	Comparative studies revealed that a beta form of recombinant human IL-1, similar to the mature peptide secreted naturally, is more powerful than other preparations of this monokine in stimulating adrenocorticotrophic hormone (ACTH) and corticosterone output.	Corticosterone	236-250	amyloid beta precursor protein	Homo sapiens	34-40
2824799-2	1987	Comparative studies revealed that a beta form of recombinant human IL-1, similar to the mature peptide secreted naturally, is more powerful than other preparations of this monokine in stimulating adrenocorticotrophic hormone (ACTH) and corticosterone output.	Corticosterone	236-250	interleukin 1 beta	Homo sapiens	67-71
2824799-4	1987	In extending our studies to rats, we showed that increased ACTH and blood corticosterone levels are also induced by IL-1 in this species.	Corticosterone	74-88	interleukin 1 complex	Mus musculus	116-120
3588658-4	1987	All three cholinesterase inhibitors caused an initial rise in corticosterone; DFP decreased growth hormone; physostigmine reduced prolactin.	Corticosterone	62-76	butyrylcholinesterase	Rattus norvegicus	10-24
3037584-2	1987	The type 1 receptor resembles the kidney mineralocorticoid receptor and has two functional expressions in brain, i.e. type 1 corticosterone (CORT) preferring sites (CR) and mineralocorticoid receptors (MR).	Corticosterone	125-139	cortistatin	Rattus norvegicus	141-145
3031746-4	1987	ANP did not affect the CRF- and AVP-induced plasma corticosterone elevation, while it attenuated the AVP-induced corticosterone elevation.	Corticosterone	113-127	natriuretic peptide A	Rattus norvegicus	0-3
3789152-7	1986	Corticosterone supplements to mirex-dosed intact rats resulted in a biphasic peak of TK activity (30- and 48-h peaks), a reduced ODC peak at 36 h, and a 48-h peak in [3H]thymidine incorporation into DNA.	Corticosterone	0-14	ornithine decarboxylase 1	Rattus norvegicus	129-132
3789152-9	1986	Corticosterone supplements to mirex-dosed ADX rats eliminated the 48-h peak of [3H]thymidine incorporation into DNA, reduced TK activity and shifted the peak to 30 h, and eliminated the ODC biphasic response.	Corticosterone	0-14	ornithine decarboxylase 1	Rattus norvegicus	186-189
3792622-4	1986	Several lines of evidence suggest that corticosterone is the principal inducer of fetal MT-I mRNA: The induction of MT-I mRNA in the liver, but not in the kidney, mimics glucocorticoid regulation but not metal regulation.	Corticosterone	39-53	metallothionein 1	Mus musculus	88-92
3792622-4	1986	Several lines of evidence suggest that corticosterone is the principal inducer of fetal MT-I mRNA: The induction of MT-I mRNA in the liver, but not in the kidney, mimics glucocorticoid regulation but not metal regulation.	Corticosterone	39-53	metallothionein 1	Mus musculus	116-120
3792622-5	1986	Reduction of maternal corticosterone levels by treating mice with metyrapone lowered MT-I mRNA levels but had no effect on zinc levels.	Corticosterone	22-36	metallothionein 1	Mus musculus	85-89
3792622-7	1986	Based on these observations, we propose that corticosterone is responsible for the induction of MT-I mRNA and that the resulting MT sequesters zinc and copper which may be used later in development.	Corticosterone	45-59	metallothionein 1	Mus musculus	96-100
3556416-9	1986	Handling of the birds during vehicle injections decreased the corticosterone level in the control chickens as compared with the intact ones; PRL raised the level of CS at 0 HALO significantly.	Corticosterone	165-167	prolactin	Gallus gallus	141-144
3758618-4	1986	The presence of corticosterone (1 microM) prevented the enhancing effect of 0.1 nM glucagon on alcohol dehydrogenase activity.	Corticosterone	16-30	aldo-keto reductase family 1 member A1	Rattus norvegicus	95-116
3769871-9	1986	The combined administration from days 2 through 11 of GH, T4, and corticosterone augmented S16 1.8-fold, a response paradoxical to that in the adult animal, but consistent with advancing maturation of the liver.	Corticosterone	66-80	ribosomal protein S16	Homo sapiens	91-94
3021625-7	1986	Infusion of angiotensin II intraperitoneally prevented the rise in adrenal renin after nephrectomy (from 65.25 +/- 7.60 to 9.27 +/- 0.99 ng angiotensin I/mg protein/hr) despite an increase in plasma potassium and corticosterone.	Corticosterone	213-227	angiotensinogen	Rattus norvegicus	12-26
3793013-4	1986	The combination of growth hormone (1 microgram per ml) and corticosterone (1 microM) increased alcohol dehydrogenase activity in hepatocytes from normal rats, while neither hormone alone had an effect.	Corticosterone	59-73	aldo-keto reductase family 1 member A1	Rattus norvegicus	95-116
3793013-6	1986	The increases in alcohol dehydrogenase, due to the exposure of the hepatocytes to the combination of growth hormone and corticosterone, were associated with increases in the rate of ethanol elimination.	Corticosterone	120-134	aldo-keto reductase family 1 member A1	Rattus norvegicus	17-38
3793013-7	1986	These observations indicate that growth hormone enhances liver alcohol dehydrogenase activity and ethanol elimination, and that this effect is dependent on the permissive influence of corticosterone.	Corticosterone	184-198	gonadotropin releasing hormone receptor	Rattus norvegicus	33-47
3023203-3	1986	Cimetidine and ranitidine at 320 and 1000 micrograms/ml inhibited ACTH-stimulated corticosterone and cortisol synthesis and cimetidine decreased basal cortisol synthesis.	Corticosterone	82-96	proopiomelanocortin	Homo sapiens	66-70
3493242-3	1986	When added to a cytochrome P-450(11)beta-reconstituted system in the presence of dilauroylphosphatidylcholine, calmodulin decreased the rate of aldosterone production from corticosterone from 0.8 to 0.1 nmol/(min X nmol P-450), while it increased the rate of 18-hydroxycorticosterone production from 1.8 to 4.6 nmol/(min X nmol P-450).	Corticosterone	172-186	calmodulin	Bos taurus	111-121
3493242-7	1986	Calmodulin induced a change in the activity of cytochrome P-450(11)beta in the presence of a wide concentration range of corticosterone as a substrate.	Corticosterone	121-135	calmodulin	Bos taurus	0-10
3493242-8	1986	As for 18-hydroxycorticosterone production, calmodulin increased both the maximal activity and the apparent Km for corticosterone, but it decreased the apparent Km for adrenodoxin.	Corticosterone	17-31	calmodulin	Bos taurus	44-54
3022077-1	1986	Prolonged (7 days) methionine-enkephalin (DALA) treatment provoked a dose-dependent increase in the volume of zona fasciculata cells of dexamethasone-administered rats, along with a notable rise in the plasma concentration of corticosterone and the activity of 11 beta-hydroxylase.	Corticosterone	226-240	proenkephalin	Rattus norvegicus	30-40
2879326-6	1986	During the early postnatal period plasma corticosterone levels were inversely related to AChE and MAO activities in most GI segments.	Corticosterone	41-55	monoamine oxidase A	Rattus norvegicus	98-101
3021281-8	1986	In the latter case, CT also reduced the inhibitory effect of gamma-aminobutyric acid on PS and enhanced the excitatory action of the opioid peptide D-Ala2-D-Leu5-enkephalin.	Corticosterone	20-22	proenkephalin	Rattus norvegicus	162-172
3753516-0	1986	Possible role of endogenous histamine in mediation of LPS-induced secretion of corticosterone in mice.	Corticosterone	79-93	toll-like receptor 4	Mus musculus	54-57
3753516-1	1986	Escherichia coli lipopolysaccharide (LPS) induced a strong secretion of corticosterone in C3H/HeN mice with a concomitant increase in the splenic histidine decarboxylase activity.	Corticosterone	72-86	toll-like receptor 4	Mus musculus	37-40
3753516-3	1986	In C3H/HeJ mice, LPS provoked little corticosterone release and induction of the enzyme.	Corticosterone	37-51	toll-like receptor 4	Mus musculus	17-20
3753516-5	1986	Injection of LPS produced a comparable increase in the serum histamine and corticosterone level and activity of histidine decarboxylase in various tissues of genetically mast-cell-deficient W/WV mice and in closely related +/+ mice.	Corticosterone	75-89	toll-like receptor 4	Mus musculus	13-16
3753516-6	1986	These results suggest that secretion of corticosterone caused by LPS is mediated by histamine produced through induction of histidine decarboxylase in non-mast cells.	Corticosterone	40-54	toll-like receptor 4	Mus musculus	65-68
3753516-6	1986	These results suggest that secretion of corticosterone caused by LPS is mediated by histamine produced through induction of histidine decarboxylase in non-mast cells.	Corticosterone	40-54	histidine decarboxylase	Mus musculus	124-147
2945127-2	1986	administration of angiotensin II (AII) and atrial natriuretic polypeptide (ANP) on the plasma corticosterone level were studied in conscious, unrestrained rats.	Corticosterone	94-108	angiotensinogen	Rattus norvegicus	18-32
2945127-2	1986	administration of angiotensin II (AII) and atrial natriuretic polypeptide (ANP) on the plasma corticosterone level were studied in conscious, unrestrained rats.	Corticosterone	94-108	natriuretic peptide A	Rattus norvegicus	75-78
2945127-4	1986	injection of ANP had no apparent effect on the basal plasma corticosterone level, it attenuated the plasma corticosterone increase induced by centrally injected AII dose-dependently.	Corticosterone	107-121	natriuretic peptide A	Rattus norvegicus	13-16
2945127-4	1986	injection of ANP had no apparent effect on the basal plasma corticosterone level, it attenuated the plasma corticosterone increase induced by centrally injected AII dose-dependently.	Corticosterone	107-121	angiotensinogen	Rattus norvegicus	161-164
3019483-0	1986	Neonatal peptides affect developing rats: beta-endorphin alters nociception and opiate receptors, corticotropin-releasing factor alters corticosterone.	Corticosterone	136-150	corticotropin releasing hormone	Rattus norvegicus	98-128
3020142-5	1986	Angiotensin II (0.25 nmol/l to 0.25 mumol/l) highly significantly (P less than 0.01) stimulated aldosterone and corticosterone outputs, [32P] incorporation into phosphatidic acid and phosphatidylinositol (but not into phosphatidylcholine) and the production of the three [3H]inositol phosphates.	Corticosterone	112-126	angiotensinogen	Rattus norvegicus	0-14
3020142-6	1986	Aldosterone and corticosterone outputs were stimulated by alpha-MSH (above 0.1 nmol/l).	Corticosterone	16-30	proopiomelanocortin	Rattus norvegicus	58-67
3015230-1	1986	Treatment of mice with ACTH not only increased plasma corticosterone levels, but also reduced the ligand-binding capacity of the glucocorticoid receptor in skeletal muscle cytosol.	Corticosterone	54-68	pro-opiomelanocortin-alpha	Mus musculus	23-27
3015230-1	1986	Treatment of mice with ACTH not only increased plasma corticosterone levels, but also reduced the ligand-binding capacity of the glucocorticoid receptor in skeletal muscle cytosol.	Corticosterone	54-68	nuclear receptor subfamily 3, group C, member 1	Mus musculus	129-152
3015230-5	1986	In addition, ACTH treatment was also found to reduce the binding capacity in adrenalectomized mice that did not respond with corticosterone elevation.	Corticosterone	125-139	pro-opiomelanocortin-alpha	Mus musculus	13-17
3740258-2	1986	This suggests that corticosterone is available for transport into peripheral tissues in rabbits from the circulating CBG-bound pool, similar to what is known to occur in rat liver.	Corticosterone	19-33	corticosteroid-binding globulin	Oryctolagus cuniculus	117-120
3740258-3	1986	This hypothesis was tested in the present studies, which investigate the transport of corticosterone into rabbit brain from the circulating rabbit or human CBG-bound pool.	Corticosterone	86-100	serpin family A member 6	Homo sapiens	156-159
3740258-4	1986	Corticosterone was readily exchangeable in brain capillaries in vivo from the circulating albumin-bound and rabbit or human CBG-bound pools.	Corticosterone	0-14	serpin family A member 6	Homo sapiens	124-127
3019054-3	1986	The corticosterone binding capacity of the plasma as well as the binding capacity of CBG for corticosterone decreased in intact foetuses for the last 3 days of gestation and stayed very low in pups from day 0 to day 8 postpartum.	Corticosterone	93-107	serpin family A member 6	Rattus norvegicus	85-88
3019054-6	1986	The fall in CBG activity in normal rat pups and the subsequent rise in free steroids could explain a sharp decrease in plasma ACTH levels as well as the drop in adrenal and plasma corticosterone concentration.	Corticosterone	180-194	serpin family A member 6	Rattus norvegicus	12-15
3013598-6	1986	The biological potencies of the two ACTH preparations were identical with respect to corticosterone (B) release in the short term bioassay, with an ED50 value of 1.67 X 10(-10) M. The ED50 value for cortisol (F) release for rACTH and hACTH were 1.1 X 10(-10) M and 1.67 X 10(-10) M, respectively, which were not statistically different.	Corticosterone	85-99	proopiomelanocortin	Homo sapiens	36-40
3489629-1	1986	Long-term angiotensin-II (AII) administration provokes a time-dependent rise in the volume of zona fasciculata cells and in the plasma concentration of corticosterone in rats treated with dexamethasone and maintenance doses of ACTH.	Corticosterone	152-166	angiotensinogen	Rattus norvegicus	10-24
3489629-1	1986	Long-term angiotensin-II (AII) administration provokes a time-dependent rise in the volume of zona fasciculata cells and in the plasma concentration of corticosterone in rats treated with dexamethasone and maintenance doses of ACTH.	Corticosterone	152-166	angiotensinogen	Rattus norvegicus	26-29
3749216-3	1986	The results clearly demonstrate that oxytocin produced a significant increase in corticosterone in all OXT treated animals.	Corticosterone	81-95	oxytocin/neurophysin I prepropeptide	Homo sapiens	37-45
3749216-3	1986	The results clearly demonstrate that oxytocin produced a significant increase in corticosterone in all OXT treated animals.	Corticosterone	81-95	oxytocin/neurophysin I prepropeptide	Homo sapiens	103-106
3714710-2	1986	Dexamethasone, methylprednisolone, and corticosterone all enhanced plasma Fn levels in normal animals.	Corticosterone	39-53	fibronectin 1	Rattus norvegicus	74-76
3021558-3	1986	Daily ACTH injections of 0.1 IU/kg on 3 successive days showed a good reproducibility in response in plasma corticosterone levels.	Corticosterone	108-122	proopiomelanocortin	Homo sapiens	6-10
3021558-6	1986	A rather low correlation (r = 0.49) existed between individual baseline levels of plasma corticosterone and adrenal sensitivity for ACTH.	Corticosterone	89-103	proopiomelanocortin	Homo sapiens	132-136
3703872-2	1986	Bovine growth hormone (0.5 mg GH/kg body wt/day for 18 days) enhanced body weight gain and shank-toe length increase (an estimate of bone growth) by 46 and 33%, respectively, compared to the growth of hypophysectomized chickens receiving only corticosterone.	Corticosterone	243-257	growth hormone	Gallus gallus	7-21
3521182-2	1986	Treatment with a chloride-deficient diet led to a temporary decrease in the capsular adrenal conversions of corticosterone to 18-hydroxycorticosterone and aldosterone (manifest after 2 weeks but not longer apparent after 3 weeks), which was accompanied by a progressive rise in plasma renin activity and a moderate fall in plasma potassium.	Corticosterone	108-122	renin	Rattus norvegicus	285-290
3711757-11	1986	There was a significant correlation (r = 0.82, n = 9, P less than 0.01) between the mean corticosterone and transcortin concentrations (measured at 21.00 h).	Corticosterone	89-103	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	108-119
2869788-2	1986	Injecting 1 mg of dexamethasone or corticosterone into 150-250 g adrenalectomized rats caused a rapid decline in glucocorticoid receptor binding.	Corticosterone	35-49	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	113-136
3007214-1	1986	Isolated fasciculata cells of rat adrenal cortex, when incubated with atrial natriuretic factor (ANF), stimulated the levels of cyclic GMP and corticosterone production in a concentration-dependent manner without a rise in the levels of cyclic AMP.	Corticosterone	143-157	natriuretic peptide A	Rattus norvegicus	70-95
3007214-1	1986	Isolated fasciculata cells of rat adrenal cortex, when incubated with atrial natriuretic factor (ANF), stimulated the levels of cyclic GMP and corticosterone production in a concentration-dependent manner without a rise in the levels of cyclic AMP.	Corticosterone	143-157	natriuretic peptide A	Rattus norvegicus	97-100
3715917-2	1986	Corticosterone inhibited aryl hydrocarbon hydroxylase (AHH) activity nonlinearly in hepatic microsomes from uninduced, phenobarbital-induced, or 3-methylcholanthrene-induced rats.	Corticosterone	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	25-53
3715917-2	1986	Corticosterone inhibited aryl hydrocarbon hydroxylase (AHH) activity nonlinearly in hepatic microsomes from uninduced, phenobarbital-induced, or 3-methylcholanthrene-induced rats.	Corticosterone	0-14	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	55-58
3961813-5	1986	Chickens given 200 ppm corticosterone without TOTP or DFP had significantly elevated activity of plasma cholinesterase and significantly inhibited activity of liver carboxylesterase.	Corticosterone	23-37	butyrylcholinesterase	Gallus gallus	104-118
3513611-0	1986	LPS-caused secretion of corticosterone is mediated by histamine through histidine decarboxylase.	Corticosterone	24-38	histidine decarboxylase	Mus musculus	72-95
3513611-7	1986	There was a statistically significant relationship between the activity of splenic histidine decarboxylase and the serum levels of CS.	Corticosterone	131-133	histidine decarboxylase	Mus musculus	83-106
3513611-8	1986	These results suggest that the LPS-induced secretion of CS is mediated by histamine through induction of histidine decarboxylase in the spleen, lung, and liver.	Corticosterone	56-58	histidine decarboxylase	Mus musculus	105-128
3720022-2	1986	alpha-Lactalbumin production by mammary gland explants from mid-pregnant rats has been shown in previous studies to be increased by high doses of aldosterone, but not by deoxycorticosterone; in six of 11 experiments corticosterone, the physiological glucocorticoid in the rat, elevated alpha-lactalbumin; in five other studies corticosterone had no effect.	Corticosterone	216-230	lactalbumin, alpha	Rattus norvegicus	0-17
3948773-9	1986	The marked increase in tissue transcortin ([3H]corticosterone binding in the presence of excess dexamethasone) suggested that plasma transcortin is sequestered by peripheral tissues in substantial amounts in the acutely adrenalectomized rat.	Corticosterone	47-61	serpin family A member 6	Rattus norvegicus	30-41
3948773-9	1986	The marked increase in tissue transcortin ([3H]corticosterone binding in the presence of excess dexamethasone) suggested that plasma transcortin is sequestered by peripheral tissues in substantial amounts in the acutely adrenalectomized rat.	Corticosterone	47-61	serpin family A member 6	Rattus norvegicus	133-144
2422455-4	1986	Conversely, in the absence of calcium, angiotensin II (10(-7) M) was still able to stimulate corticosterone and aldosterone production.	Corticosterone	93-107	angiotensinogen	Homo sapiens	39-53
2422455-7	1986	At the higher dose (10(-4) M), verapamil totally inhibited the stimulation of corticosterone and aldosterone production induced by ACTH.	Corticosterone	78-92	proopiomelanocortin	Homo sapiens	131-135
3754566-6	1986	Production of corticosterone was activated by PRL injection and its serum level reached the maximal value 24 hours after the injection.	Corticosterone	14-28	prolactin	Rattus norvegicus	46-49
3754566-9	1986	Furthermore, the lag time between corticosterone and DSPC production indicated DSPC biosynthesis may be dependent on increased corticosterone after PRL administration.	Corticosterone	34-48	prolactin	Rattus norvegicus	148-151
3754566-9	1986	Furthermore, the lag time between corticosterone and DSPC production indicated DSPC biosynthesis may be dependent on increased corticosterone after PRL administration.	Corticosterone	127-141	prolactin	Rattus norvegicus	148-151
3006413-5	1986	The maximum AII-stimulated levels, but not the basal levels, of pregnenolone, corticosterone and 18-OHB production were low in the cells from heparin-treated rats.	Corticosterone	78-92	angiotensinogen	Rattus norvegicus	12-15
3003477-3	1986	Whereas DBH activity remained unchanged, adrenal PNMT activity was increased significantly following ACTH-induced elevation of plasma corticosterone levels.	Corticosterone	134-148	phenylethanolamine-N-methyltransferase	Rattus norvegicus	49-53
3006659-7	1986	After injury, however, PEPCK synthesis was unaffected by either alpha beta-blockade or trilostane, although it was decreased by their combined action; and it seems that either corticosterone or sympathetic stimulation was sufficient to stimulate PEPCK synthesis maximally.	Corticosterone	176-190	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	246-251
3004733-11	1986	The mechanism underlying the "aldosterone-escape" phenomenon may thus involve a rise in the intracellular concentration of corticosterone, caused by the enhanced synthesis and activation of 3 beta HSD and 11 beta OH.	Corticosterone	123-137	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	190-200
3080257-3	1986	In contrast, following TRH administration (4 mg/kg, iv), an increase in mean arterial pressure was associated with significant increases in plasma epinephrine, norepinephrine, and corticosterone.	Corticosterone	180-194	thyrotropin releasing hormone	Rattus norvegicus	23-26
2876827-1	1986	Treatment with long acting ACTH (20 IU kg-1) produces a large and sustained elevation of plasma corticosterone in the domestic fowl.	Corticosterone	96-110	proopiomelanocortin	Homo sapiens	27-31
2416521-5	1986	Accumulations of amylase and lipase in the pancreas of the rat pups were increased by fasting, with an accompanied surge in the level of serum corticosterone.	Corticosterone	143-157	lipase G, endothelial type	Rattus norvegicus	29-35
3030719-7	1986	In the present studies, intact dispersed rat adrenal fasciculata cells fused with liposomal encapsulated anti-SCP2 IgG showed a 40-65% reduction in their ability to produce corticosterone when stimulated with ACTH.	Corticosterone	173-187	sterol carrier protein 2	Rattus norvegicus	110-114
3510121-0	1986	A complex noncoordinate regulation of alpha-lactalbumin and 25 K beta-casein by corticosterone, prolactin, and insulin in long term cultures of normal rat mammary cells.	Corticosterone	80-94	lactalbumin, alpha	Rattus norvegicus	38-55
3510121-0	1986	A complex noncoordinate regulation of alpha-lactalbumin and 25 K beta-casein by corticosterone, prolactin, and insulin in long term cultures of normal rat mammary cells.	Corticosterone	80-94	casein beta	Rattus norvegicus	65-76
3510121-6	1986	alpha LA was increased more by insulin than by PRL, and beta-casein was enhanced more by insulin than by corticosterone.	Corticosterone	105-119	casein beta	Rattus norvegicus	56-67
3702410-1	1986	The rat brain contains two receptor systems for corticosterone (CORT): the glucocorticoid (GR) and corticosterone or mineralocorticoid-like (CR) receptor sites.	Corticosterone	48-62	cortistatin	Rattus norvegicus	64-68
3702410-1	1986	The rat brain contains two receptor systems for corticosterone (CORT): the glucocorticoid (GR) and corticosterone or mineralocorticoid-like (CR) receptor sites.	Corticosterone	99-113	cortistatin	Rattus norvegicus	64-68
3005899-2	1986	ACTH and corticosterone were elevated to at least the same level in rats treated with the inhibitors as they were in rats treated with the corresponding vehicles; indeed, ACTH values were somewhat greater in stressed rats treated with the converting enzyme inhibitors and the renin inhibitor.	Corticosterone	9-23	renin	Rattus norvegicus	276-281
3010158-3	1986	In subiculum, dentate gyrus, and dorsal raphe nucleus the 5-HT1 receptor density was restored (decreased) towards the level observed in sham-operated rats after administration of a low dose of corticosterone (CORT) at the time of ADX.	Corticosterone	193-207	cortistatin	Rattus norvegicus	209-213
20493065-9	1986	(5) In the intraventricular experiments reported above neuropeptide Y (1.25 nmol, 1 h) reduced the serum levels of thyreotropin stimulating hormone, prolactin and luteinizing hormone and increased serum corticosterone, adrenocorticotrophin, vasopressin, angiotensin II and aldosterone levels.	Corticosterone	203-217	neuropeptide Y	Rattus norvegicus	55-69
20493065-11	1986	Neuropeptide Y together with the tyrosine hydroxylase inhibitor further enhanced the adrenocorticotrophin, angiotensin II and aldosterone serum levels seen with the inhibitor, but could no longer produce its excitatory and inhibitory effects on serum corticosterone and luteinizing hormone levels, respectively.	Corticosterone	251-265	neuropeptide Y	Rattus norvegicus	0-14
20493065-14	1986	In addition, it is suggested that the ability of neuropeptide Y to increase adrenocorticotrophin and corticosterone secretion is at least in part related to its ability to reduce noradrenaline turnover in the parvocellular part of the paraventricular hypothalamic nucleus, rich in corticotrophin releasing factor immunoreactive nerve cell bodies.	Corticosterone	101-115	neuropeptide Y	Rattus norvegicus	49-63
3003661-6	1986	As hyperthyroidism was associated with marked elevations in the concentration of corticosteroid-binding globulin and in the extent of binding of corticosterone, these results suggest that the effects of both age and thyroid status on serum concentrations of corticosterone may reflect changes in the metabolic clearance of the hormone.	Corticosterone	258-272	serpin family A member 6	Rattus norvegicus	81-112
3737740-7	1986	An important relationship between corticosterone release and prolactin secretion is also indicated.	Corticosterone	34-48	prolactin	Rattus norvegicus	61-70
3008140-2	1986	Adrenocortical response, as indicated by corticosterone concentrations, was greater early in the photoperiod in cockerels exposed to HS or injected with ACTH.	Corticosterone	41-55	proopiomelanocortin	Homo sapiens	153-157
3018821-0	1986	Cortisol and corticosterone response after syn-corticotropin in relationship to dexamethasone suppressibility of cortisol.	Corticosterone	13-27	synemin	Homo sapiens	43-46
3018821-5	1986	Cortisol and corticosterone responses after syn-ACTH tended to be higher during depression.	Corticosterone	13-27	synemin	Homo sapiens	44-47
3018821-5	1986	Cortisol and corticosterone responses after syn-ACTH tended to be higher during depression.	Corticosterone	13-27	proopiomelanocortin	Homo sapiens	48-52
4075151-4	1985	The present report demonstrates such a synergy between corticosterone (CORT), the species-specific glucocorticoid of rats, and 3-acetylpyridine (3-AP), a neurotoxic antimetabolite which inhibits ATP synthesis.	Corticosterone	55-69	cortistatin	Rattus norvegicus	71-75
2998738-1	1985	Two receptor systems for corticosterone (CORT) can be distinguished in rat brain: mineralocorticoid-like or CORT receptors (CR) and glucocorticoid receptors (GR).	Corticosterone	25-39	cortistatin	Rattus norvegicus	41-45
2998738-1	1985	Two receptor systems for corticosterone (CORT) can be distinguished in rat brain: mineralocorticoid-like or CORT receptors (CR) and glucocorticoid receptors (GR).	Corticosterone	25-39	cortistatin	Rattus norvegicus	108-112
3000997-2	1985	Plasma corticosterone significantly increased (P less than 0.01) from a mean (+/- SD) basal concentration of 3.25 +/ 3.6 ng/ml to 26.47 +/- 9.25 (one hour after ACTH administration) and 25.69 +/- 13.23 ng/ml (2 hours after ACTH administration).	Corticosterone	7-21	proopiomelanocortin	Homo sapiens	161-165
3000997-2	1985	Plasma corticosterone significantly increased (P less than 0.01) from a mean (+/- SD) basal concentration of 3.25 +/ 3.6 ng/ml to 26.47 +/- 9.25 (one hour after ACTH administration) and 25.69 +/- 13.23 ng/ml (2 hours after ACTH administration).	Corticosterone	7-21	proopiomelanocortin	Homo sapiens	223-227
3000997-6	1985	Plasma corticosterone concentrations in cockatoos, macaws, Amazon parrots, conures, and lorikeets before and after ACTH administration indicated that the ACTH stimulation test could be used to evaluate adrenal secretory capacity in psittacine birds.	Corticosterone	7-21	proopiomelanocortin	Homo sapiens	154-158
4056790-2	1985	In this investigation, we have examined the transformation (activation) of the cytosolic receptor coupled to [3H]dexamethasone (DEX) and the in vivo interaction of adrenal hormone [corticosterone (CORT)] with purified nuclei from the SC, in addition to the CORT content of the SC before and after stress.	Corticosterone	181-195	cortistatin	Rattus norvegicus	197-201
4094416-1	1985	The effect of the glucocorticoid-antagonist RU486 (Roussel-Uclaf, France) on the increased activity of hepatic tryptophan oxygenase (TO) after administration of corticosterone and ethanol in rats was studied.	Corticosterone	161-175	tryptophan 2,3-dioxygenase	Rattus norvegicus	111-131
2419176-7	1985	The maximal AII-stimulated levels, but not the basal levels, of pregnenolone, corticosterone and 18-hydroxycorticosterone production were low in the cells from dextran sulfate-treated rats.	Corticosterone	78-92	angiotensinogen	Rattus norvegicus	12-15
2996938-2	1985	The present report describes a comparison of the effect produced by ANF on aldosterone, deoxycorticosterone and progesterone secretions by zona glomerulosa cells and on cortisol, corticosterone and progesterone secretions by zona fasciculata cells.	Corticosterone	93-107	natriuretic peptide A	Bos taurus	68-71
4042964-7	1985	Upon acute corticosterone treatment of adrenalectomized male rats, the GR immunoreactivity was again mainly demonstrated in the nerve cell nuclei indicating that corticosterone can translocate GR from the cytoplasm to the cell nuclei.	Corticosterone	11-25	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	71-73
4042964-7	1985	Upon acute corticosterone treatment of adrenalectomized male rats, the GR immunoreactivity was again mainly demonstrated in the nerve cell nuclei indicating that corticosterone can translocate GR from the cytoplasm to the cell nuclei.	Corticosterone	11-25	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	193-195
4042964-7	1985	Upon acute corticosterone treatment of adrenalectomized male rats, the GR immunoreactivity was again mainly demonstrated in the nerve cell nuclei indicating that corticosterone can translocate GR from the cytoplasm to the cell nuclei.	Corticosterone	162-176	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	71-73
4042964-7	1985	Upon acute corticosterone treatment of adrenalectomized male rats, the GR immunoreactivity was again mainly demonstrated in the nerve cell nuclei indicating that corticosterone can translocate GR from the cytoplasm to the cell nuclei.	Corticosterone	162-176	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	193-195
4079382-0	1985	Biopotency of corticosterone and dexamethasone in causing glucocorticoid receptor downregulation.	Corticosterone	14-28	nuclear receptor subfamily 3, group C, member 1	Mus musculus	58-81
4079382-1	1985	The biopotencies of dexamethasone and corticosterone in causing glucocorticoid receptor downregulation in the AtT-20 cell were assessed and compared to their affinity for the isolated, cytosolic glucocorticoid receptor.	Corticosterone	38-52	nuclear receptor subfamily 3, group C, member 1	Mus musculus	64-87
3938841-7	1985	By contrast, when tested on rat adrenal glomerulosa cells, salmonid MCH had no effect alone but at a concentration of greater than 10(-10) M it slightly reduced corticosterone production by an alpha-MSH concentration of 10(-7) M. Aldosterone production was not affected and MCH did not influence the response to ACTH.	Corticosterone	161-175	proopiomelanocortin	Rattus norvegicus	193-202
2995861-2	1985	We studied the effects of this nonapeptide on corticotropin releasing factor (CRF)-stimulated release of corticosterone in rats treated with chlorpromazine-morphine-pentobarbital.	Corticosterone	105-119	corticotropin releasing hormone	Rattus norvegicus	46-76
4085662-7	1985	The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively.	Corticosterone	41-55	hematopoietic prostaglandin D synthase	Rattus norvegicus	37-40
4085662-7	1985	The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively.	Corticosterone	41-55	hematopoietic prostaglandin D synthase	Rattus norvegicus	150-153
4085662-7	1985	The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively.	Corticosterone	41-55	hematopoietic prostaglandin D synthase	Rattus norvegicus	150-153
4085662-7	1985	The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively.	Corticosterone	94-108	hematopoietic prostaglandin D synthase	Rattus norvegicus	37-40
4085662-7	1985	The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively.	Corticosterone	94-108	hematopoietic prostaglandin D synthase	Rattus norvegicus	150-153
4085662-7	1985	The dissociation constant of anionic GST-corticosterone complex was as low as 2.0 X 10(-8) M. Corticosterone inhibited the enzyme activity of anionic GST in a noncompetitive fashion with an apparent Ki value of 8.6 X 10(-5) M and 1.1 X 10(-6) M for 1-chloro-2.4-dinitrobenzene and GST respectively.	Corticosterone	94-108	hematopoietic prostaglandin D synthase	Rattus norvegicus	150-153
4085662-8	1985	The anionic GST-corticosterone complex bound to DNA coupled Sepharose at 25 degrees C and passed through the column at 4 degrees C. Conversely, the complex bound to a DEAE cellulose column at 4 degrees C but passed through at 25 degrees C. These properties of anionic GST are quite similar to those of glucocorticoid receptor of rat liver cytosol reported previously.	Corticosterone	16-30	hematopoietic prostaglandin D synthase	Rattus norvegicus	12-15
4085662-8	1985	The anionic GST-corticosterone complex bound to DNA coupled Sepharose at 25 degrees C and passed through the column at 4 degrees C. Conversely, the complex bound to a DEAE cellulose column at 4 degrees C but passed through at 25 degrees C. These properties of anionic GST are quite similar to those of glucocorticoid receptor of rat liver cytosol reported previously.	Corticosterone	16-30	hematopoietic prostaglandin D synthase	Rattus norvegicus	268-271
4085662-8	1985	The anionic GST-corticosterone complex bound to DNA coupled Sepharose at 25 degrees C and passed through the column at 4 degrees C. Conversely, the complex bound to a DEAE cellulose column at 4 degrees C but passed through at 25 degrees C. These properties of anionic GST are quite similar to those of glucocorticoid receptor of rat liver cytosol reported previously.	Corticosterone	16-30	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	302-325
2993777-10	1985	Significant elevations of blood glucose, corticosterone and ACTH were also observed after DBH inhibition.	Corticosterone	41-55	dopamine beta-hydroxylase	Rattus norvegicus	90-93
2864479-4	1985	The slight but significant enhancement of zona fasciculata cell growth and plasma corticosterone levels caused by chronic AII administration were ot reversed by SRIF.	Corticosterone	82-96	angiotensinogen	Rattus norvegicus	122-125
2989319-3	1985	Our data demonstrate that in normal subjects, mineralocorticoid receptor-binding steroids can be almost totally accounted for by immunoreactive deoxycorticosterone, corticosterone, cortisol, and aldo (RRA, 4.73 +/- 1.34 ng/ml aldo; RIA, 3.91 +/- 1.52 ng/ml aldo equivalents), while in 8 patients with dexamethasone-suppressible hyperaldosteronism (DSH), RRA values were greater than RIA values in the basal state (RRA, 7.57 +/- 0.75; RIA, 3.24 +/- 0.34; P less than 0.01).	Corticosterone	149-163	nuclear receptor subfamily 3 group C member 2	Homo sapiens	46-72
2989323-3	1985	During ACTH stimulation, plasma corticosterone concentrations remained low and cortisol remained high, suggesting the cortisol was of exogenous origin.	Corticosterone	32-46	proopiomelanocortin	Homo sapiens	7-11
2993990-5	1985	In 13 GH-deficient children, GH treatment caused a significant decrease in the corticosterone response to ACTH (2.2 +/- 0.2 micrograms/dl before GH to 1.6 +/- 0.2 micrograms/dl; t = 5.22, p less than 0.001; paired t test) despite the fact that there was no significant change in the cortisol response to ACTH (18 +/- 2 micrograms/dl before and 16 +/- 2 micrograms/dl after).	Corticosterone	79-93	proopiomelanocortin	Homo sapiens	106-110
2993990-7	1985	Again, the stimulated levels of cortisol were not affected by GH treatment (19 +/- 4 versus 18 +/- 3 micrograms/dl) These results indicate that GH modulates the adrenal response to ACTH by suppressing corticosterone secretion without affecting cortisol secretion.	Corticosterone	201-215	proopiomelanocortin	Homo sapiens	181-185
4027612-3	1985	Corticosterone administration reduces receptor number in the hippocampus, particularly the CA1 and CA2 pyramidal cell fields, but nowhere else in the brain or pituitary.	Corticosterone	0-14	carbonic anhydrase 1	Homo sapiens	91-94
4027612-3	1985	Corticosterone administration reduces receptor number in the hippocampus, particularly the CA1 and CA2 pyramidal cell fields, but nowhere else in the brain or pituitary.	Corticosterone	0-14	carbonic anhydrase 2	Homo sapiens	99-102
4050454-2	1985	Antiglucocorticoid properties of 11-deoxycortisol in intact rats were examined by studying the effect of 11-deoxycortisol on the induction of hepatic tryptophan oxygenase (TO) by corticosterone.	Corticosterone	179-193	tryptophan 2,3-dioxygenase	Rattus norvegicus	150-170
2408880-11	1985	DHT and CT had remarkably different effects on the percentages of cells stained for GnRH.	Corticosterone	8-10	gonadotropin releasing hormone 1	Rattus norvegicus	84-88
3876519-5	1985	However, the same doses of CRF 1-41 increased the plasma corticosterone level in sham-operated rats.	Corticosterone	57-71	corticotropin releasing hormone receptor 1	Rattus norvegicus	27-32
2999733-2	1985	Previous investigations have demonstrated that IP injections of bombesin and CCK-33 increased corticosterone secretion in conscious, freely-moving, fed rats.	Corticosterone	94-108	cholecystokinin	Canis lupus familiaris	77-80
2997858-2	1985	ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells.	Corticosterone	65-79	proopiomelanocortin	Homo sapiens	0-4
2997858-2	1985	ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells.	Corticosterone	65-79	proopiomelanocortin	Homo sapiens	12-16
2997858-2	1985	ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells.	Corticosterone	65-79	proopiomelanocortin	Homo sapiens	12-16
2997858-2	1985	ACTH-(4-7), ACTH-(6-10), ACTH-(4-10) and ACTH-(11-13) stimulated corticosterone production of the zona fasciculata and aldosterone production of the zona glomerulosa cells.	Corticosterone	65-79	proopiomelanocortin	Homo sapiens	12-16
3873659-5	1985	The threshold for a significant corticosterone response was found to be at least 250-fold lower for CRF-41 than for AVP.	Corticosterone	32-46	arginine vasopressin	Rattus norvegicus	116-119
3016950-1	1985	Using cultured Y-1 mouse adrenal tumor cells which produce 20 alpha-hydroxy-4-pregnen-3-one (20-DHP), it was found that 0.01 mM corticosterone and deoxycorticosterone increased basal and inhibited ACTH-induced 20-DHP production during consecutive 30 and 120 min incubations.	Corticosterone	128-142	pro-opiomelanocortin-alpha	Mus musculus	197-201
3016950-1	1985	Using cultured Y-1 mouse adrenal tumor cells which produce 20 alpha-hydroxy-4-pregnen-3-one (20-DHP), it was found that 0.01 mM corticosterone and deoxycorticosterone increased basal and inhibited ACTH-induced 20-DHP production during consecutive 30 and 120 min incubations.	Corticosterone	128-142	dihydropyrimidinase	Mus musculus	213-216
3016950-5	1985	Corticosterone (0.01 mM) increased basal and inhibited ACTH-induced intracellular cyclic AMP (cAMP) production.	Corticosterone	0-14	pro-opiomelanocortin-alpha	Mus musculus	55-59
4021483-1	1985	In certain circumstances the activity of cholesterol ester hydrolase (CEH) activity is believed to be rate-limiting for corticosterone production by the adrenal.	Corticosterone	120-134	epoxide hydrolase 2	Rattus norvegicus	41-68
4021483-1	1985	In certain circumstances the activity of cholesterol ester hydrolase (CEH) activity is believed to be rate-limiting for corticosterone production by the adrenal.	Corticosterone	120-134	epoxide hydrolase 2	Rattus norvegicus	70-73
4021483-2	1985	The principal aim of the current study was to determine whether the activity of CEH displays a developmental increase in the infant rat which could, in part, account for the marked increase in serum corticosterone which begins at the end of the second postnatal week.	Corticosterone	199-213	carboxylesterase 1	Homo sapiens	80-83
4021483-3	1985	The data show that the specific activity of CEH (units/mg cytosolic protein) during development is actually a mirror image of the pattern seen for serum corticosterone, i.e. CEH activities are high when serum corticosterone concentrations are low and then fall when serum corticosterone is rising.	Corticosterone	153-167	epoxide hydrolase 2	Rattus norvegicus	44-47
4021483-3	1985	The data show that the specific activity of CEH (units/mg cytosolic protein) during development is actually a mirror image of the pattern seen for serum corticosterone, i.e. CEH activities are high when serum corticosterone concentrations are low and then fall when serum corticosterone is rising.	Corticosterone	153-167	epoxide hydrolase 2	Rattus norvegicus	174-177
4021483-3	1985	The data show that the specific activity of CEH (units/mg cytosolic protein) during development is actually a mirror image of the pattern seen for serum corticosterone, i.e. CEH activities are high when serum corticosterone concentrations are low and then fall when serum corticosterone is rising.	Corticosterone	209-223	epoxide hydrolase 2	Rattus norvegicus	44-47
4021483-3	1985	The data show that the specific activity of CEH (units/mg cytosolic protein) during development is actually a mirror image of the pattern seen for serum corticosterone, i.e. CEH activities are high when serum corticosterone concentrations are low and then fall when serum corticosterone is rising.	Corticosterone	209-223	epoxide hydrolase 2	Rattus norvegicus	174-177
4021483-3	1985	The data show that the specific activity of CEH (units/mg cytosolic protein) during development is actually a mirror image of the pattern seen for serum corticosterone, i.e. CEH activities are high when serum corticosterone concentrations are low and then fall when serum corticosterone is rising.	Corticosterone	209-223	epoxide hydrolase 2	Rattus norvegicus	44-47
4021483-3	1985	The data show that the specific activity of CEH (units/mg cytosolic protein) during development is actually a mirror image of the pattern seen for serum corticosterone, i.e. CEH activities are high when serum corticosterone concentrations are low and then fall when serum corticosterone is rising.	Corticosterone	209-223	epoxide hydrolase 2	Rattus norvegicus	174-177
2986721-7	1985	In vitro treatment of rat whole liver homogenate with various doses (10(-9) - 10(-5) M) of dexamethasone and corticosterone for 15 min at 22 degrees C resulted in a dose-dependent decrease in prolactin binding activity.	Corticosterone	109-123	prolactin	Rattus norvegicus	192-201
3998818-2	1985	Cumulative exposure to corticosterone (CORT) over the lifespan may be a cause of this neuronal loss, as it is prevented by adrenalectomy at mid-age.	Corticosterone	23-37	cortistatin	Rattus norvegicus	39-43
3998819-4	1985	Rats were either adrenalectomized, intact, or treated with corticosterone (CORT) sufficient to produce prolonged elevations of titers in the high physiological range.	Corticosterone	59-73	cortistatin	Rattus norvegicus	75-79
2830101-3	1987	Since molar concentrations of corticosterone produced in the medium were below the transcortin concentration at all levels of stimulation, protein-unbound corticosterone in the medium may have been largely reduced by the addition of transcortin.	Corticosterone	30-44	serpin family A member 6	Rattus norvegicus	233-244
2830101-3	1987	Since molar concentrations of corticosterone produced in the medium were below the transcortin concentration at all levels of stimulation, protein-unbound corticosterone in the medium may have been largely reduced by the addition of transcortin.	Corticosterone	155-169	serpin family A member 6	Rattus norvegicus	233-244
2987773-1	1985	Tetracosactrin, a synthetic adrenocorticotrophic hormone (ACTH) analogue delivered by osmotic minipumps implanted s.c. in mice induced a dose-dependent increase of plasma corticosterone levels.	Corticosterone	171-185	pro-opiomelanocortin-alpha	Mus musculus	58-62
3973528-0	1985	Effect of a single injection of prolactin on the serum concentrations of thyroid hormones and corticosterone and liver monodeiodinase in the domestic fowl before and after hatching.	Corticosterone	94-108	prolactin	Gallus gallus	32-41
3973528-6	1985	Serum concentrations of corticosterone after injection of 1 or 10 micrograms prolactin were doubled compared with controls.	Corticosterone	24-38	prolactin	Gallus gallus	77-86
3973528-8	1985	This effect, however, is not mediated through a prolactin-induced corticosterone release.	Corticosterone	66-80	prolactin	Gallus gallus	48-57
2987773-4	1985	Adrenalectomy before administration of the ACTH analogue prevented both the increase of plasma corticosterone and loss of malaria immunity.	Corticosterone	95-109	pro-opiomelanocortin-alpha	Mus musculus	43-47
3986609-10	1985	In adults corticosterone treatment decreased (-45%) and long-term adrenalectomy increased (211%) glucocorticoid receptor concentrations.	Corticosterone	10-24	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	97-120
3918139-6	1985	The steroid binding specificities of human and ape (CBG corticosterone greater than cortisol greater than progesterone greater than or equal to testosterone) were also different from those of Old World monkey CBG (corticosterone much greater than cortisol approximately equal to progesterone greater than testosterone).	Corticosterone	56-70	serpin family A member 6	Homo sapiens	52-55
2986762-1	1985	The effect of adrenalectomy (ADX) and corticosterone (CORT) replacement on neurotransmitter receptors was studied in dorsal hippocampus of rat using quantitative autoradiography.	Corticosterone	38-52	cortistatin	Rattus norvegicus	54-58
3974795-3	1985	Moreover, ADX increased 5-HT1 binding sites in response to VIP in various subfields of the hippocampus as well as in the superior colliculus and in the dorsal lateral septum, but this effect was not observed in normal or in ADX rats bearing a corticosterone implant.	Corticosterone	243-257	vasoactive intestinal peptide	Rattus norvegicus	59-62
3918139-6	1985	The steroid binding specificities of human and ape (CBG corticosterone greater than cortisol greater than progesterone greater than or equal to testosterone) were also different from those of Old World monkey CBG (corticosterone much greater than cortisol approximately equal to progesterone greater than testosterone).	Corticosterone	214-228	serpin family A member 6	Homo sapiens	209-212
2981848-0	1985	Effect of P-450scc inhibitors on corticosterone production by rat adrenal cells.	Corticosterone	33-47	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	10-18
2981848-3	1985	We have examined the effect of a variety of P-450scc inhibitors on corticosterone production by isolated rat adrenocortical cells.	Corticosterone	67-81	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	44-52
2982239-7	1985	The fasciculata steroids cortisol, 11-deoxycorticosterone and corticosterone were continuously stimulated by ACTH.	Corticosterone	43-57	proopiomelanocortin	Homo sapiens	109-113
3982032-3	1985	It was found that the rat adrenal gland can utilise 23,24-dinor-5-cholen-3 beta-ol to produce corticosterone.	Corticosterone	94-108	integrin subunit beta 1	Rattus norvegicus	75-82
3982032-4	1985	Also, in contrast to the conversion of cholesterol to corticosterone which occurs in the mitochondrial fraction, the conversion of 23,24-dinor-5-cholen-3 beta-ol to corticosterone occurs in the microsomal fraction.	Corticosterone	165-179	integrin subunit beta 1	Rattus norvegicus	154-161
2986736-9	1985	The perfusion of fetal adrenal glands with the same immunological quantities of "big", "intermediate" and "little" ACTH showed that the "little" and "intermediate" forms have greater biological potency in eliciting corticosterone secretion than the "big" ACTH form.	Corticosterone	215-229	proopiomelanocortin	Homo sapiens	115-119
3880544-6	1985	When estradiol, corticosterone, and insulin are present in the culture medium, mRNAov increases from about 20 to 6500 molecules/cell by 55 h. With the same culture conditions, conalbumin mRNA increases from about 120 to 4300 molecules/cell by 52 h. After about 55 h, the level of egg white mRNAs decreases, and this reduction in mRNAov correlates with a diminished transcription of that gene.	Corticosterone	16-30	transferrin (ovotransferrin)	Gallus gallus	176-186
2989017-4	1985	The same enzymes from brain showed significant increases in their activities with both hydrocortisone or corticosterone except beta-glucuronidase; this enzyme gave activity values remaining between the control levels, after treatment with corticosterone.	Corticosterone	239-253	glucuronidase, beta	Rattus norvegicus	127-145
2989017-5	1985	The activity of mitochondrial SDH was increased after corticosterone injection either in liver or brain.	Corticosterone	54-68	serine dehydratase	Rattus norvegicus	30-33
2989017-7	1985	Glucose-6-phosphatase behaves similarly in brain or liver fractions; its activity increases always after corticosterone treatment and decreases by hydrocortisone.	Corticosterone	105-119	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	0-21
2989017-9	1985	In liver fractions, both 5"-nucleotidase and Na+-K+-Mg2+ ATPase activities increase either by corticosterone or hydrocortisone treatment, except 5"-nucleotidase which specific activity decreases in liver after hydrocortisone treatment.	Corticosterone	94-108	5' nucleotidase, ecto	Rattus norvegicus	25-40
6099814-5	1984	Activation of ACTH secretion in response to hypoglycaemia may involve a cholinergic mechanism at the hypothalamic level, with a consequent reduction in the increments of plasma cortisol and corticosterone after atropine administration.	Corticosterone	190-204	proopiomelanocortin	Homo sapiens	14-18
6096245-5	1984	A significant negative correlation was found between corticosterone and PRA, which suggest that changes in PRA were due to changes in circulating corticosterone, via feedback mechanism on renin secretion.	Corticosterone	53-67	renin	Rattus norvegicus	188-193
6096245-5	1984	A significant negative correlation was found between corticosterone and PRA, which suggest that changes in PRA were due to changes in circulating corticosterone, via feedback mechanism on renin secretion.	Corticosterone	146-160	renin	Rattus norvegicus	188-193
6332965-4	1984	When arginine vasopressin (AVP) was coadministered with CRF-41 at subthreshold doses of both peptides, a significant corticosterone response was observed.	Corticosterone	117-131	arginine vasopressin	Rattus norvegicus	14-25
6541283-0	1984	Effect of corticosterone on the prolactin response to psychological and physical stress in rats.	Corticosterone	10-24	prolactin	Rattus norvegicus	32-41
6541283-2	1984	In these studies we examined the effect of corticosterone on the PRL response to both physical (footshock) and psychological (novel environment) stress.	Corticosterone	43-57	prolactin	Rattus norvegicus	65-68
6541283-8	1984	These findings indicate that corticosterone levels of an animal can significantly attenuate the magnitude of the PRL response to both physical and psychological stress.	Corticosterone	29-43	prolactin	Rattus norvegicus	113-116
6088279-1	1984	In the course of studying the plasma adrenocorticotropic hormone (ACTH) and corticosterone responses to synthetic corticotropin releasing factor (CRF), we noted some disparity in the responses.	Corticosterone	76-90	corticotropin releasing hormone	Rattus norvegicus	114-144
6208816-3	1984	Administration of corticosterone (2 mg/day) for 14 days to estrogen-treated rats increased the concentration of gonadotrophins, testosterone and alpha 2u-globulin in the serum.	Corticosterone	18-32	alpha2u globulin	Rattus norvegicus	145-162
6208816-4	1984	The weight of accessory sex organs and spermatogenesis appeared to be normal while 17 beta-HSD activity increased in estrogen-treated rats after treatment with corticosterone.	Corticosterone	160-174	hydroxysteroid (17-beta) dehydrogenase 3	Rattus norvegicus	83-94
6208816-5	1984	It is concluded that corticosterone has an effect on testicular function by inducing alpha 2u-globulin and gonadotrophins in estrogen treated rats.	Corticosterone	21-35	alpha2u globulin	Rattus norvegicus	85-102
6384414-5	1984	Insulin was able to reverse the inhibition induced by GH and corticosterone on both FFA uptake and alpha-GP production.	Corticosterone	61-75	insulin	Anas platyrhynchos	0-7
6088631-6	1984	Glucocorticoids (hydrocortisone, corticosterone, dexamethasone, prednisolone, and fludrocortisone) antagonized the induction of Ia antigens by IFN-gamma, whereas sex steroids (progesterone, estradiol, and testosterone) and a mineralocorticoid (aldosterone) did not.	Corticosterone	33-47	interferon gamma	Homo sapiens	143-152
6380888-6	1984	Aldosterone lowered plasma renin activity and reduced fluid (0.3% NaCl) intake; these effects were diminished when aldosterone and corticosterone were infused simultaneously.	Corticosterone	131-145	renin	Rattus norvegicus	27-32
6482428-4	1984	Corticosterone also shows highest affinity to plasma transcortin and thymus cytosol in the presence of RU 26988.	Corticosterone	0-14	serpin family A member 6	Rattus norvegicus	53-64
6381173-3	1984	Addition of dexamethasone (DEX) or corticosterone to the medium resulted in a large increase in PNMT activity and bright PNMT immunoreactive (PNMT-IR) staining in cells resembling small, intensely fluorescent (SIF) cells.	Corticosterone	35-49	phenylethanolamine-N-methyltransferase	Rattus norvegicus	96-100
6381173-3	1984	Addition of dexamethasone (DEX) or corticosterone to the medium resulted in a large increase in PNMT activity and bright PNMT immunoreactive (PNMT-IR) staining in cells resembling small, intensely fluorescent (SIF) cells.	Corticosterone	35-49	phenylethanolamine-N-methyltransferase	Rattus norvegicus	121-125
6381173-3	1984	Addition of dexamethasone (DEX) or corticosterone to the medium resulted in a large increase in PNMT activity and bright PNMT immunoreactive (PNMT-IR) staining in cells resembling small, intensely fluorescent (SIF) cells.	Corticosterone	35-49	phenylethanolamine-N-methyltransferase	Rattus norvegicus	121-125
6386560-1	1984	The effect of daily injections of corticosterone (about 0.85 or 4.3 mg/day) on corticosterone-insulin interactions were investigated in ad libitum-fed chickens.	Corticosterone	34-48	insulin	Gallus gallus	94-101
6386560-7	1984	Additionally, in both tests, plasma insulin levels were increased in corticosterone-treated animals.	Corticosterone	69-83	insulin	Gallus gallus	36-43
6466361-10	1984	However, experiments with different corticosterone doses showed that ethanol-induced increases in plasma corticosterone concentrations are high enough to cause an increase in liver tryptophan oxygenase activity.	Corticosterone	36-50	tryptophan 2,3-dioxygenase	Rattus norvegicus	181-201
6466361-10	1984	However, experiments with different corticosterone doses showed that ethanol-induced increases in plasma corticosterone concentrations are high enough to cause an increase in liver tryptophan oxygenase activity.	Corticosterone	105-119	tryptophan 2,3-dioxygenase	Rattus norvegicus	181-201
6146534-1	1984	gamma-Glutamyl transpeptidase activity was assayed in midpregnant rat mammary gland explants at 14, 22 and 38 h, in the presence and absence of insulin, prolactin and corticosterone.	Corticosterone	167-181	gamma-glutamyltransferase 1	Rattus norvegicus	0-29
24924078-2	1984	It was found that (1) preventing corticosterone responses to shock occludes the facilitatory effects of single shock on both aggressive and submissive behaviour and occludes the additional increases in submissive behaviour which normally occur after repeated shock, and (2) blocking pituitary release of ACTH by dexamethasone treatment restores aggressive behaviour after repeated shock, independently of the initial levels of corticosterone and testosterone.	Corticosterone	33-47	pro-opiomelanocortin-alpha	Mus musculus	304-308
6733543-0	1984	Effects of corticosterone on the electrophysiology of hippocampal CA1 pyramidal cells in vitro.	Corticosterone	11-25	carbonic anhydrase 1	Rattus norvegicus	66-69
6087372-6	1984	It is concluded that the prolonged exposure to ACTH presumably causes a corticosterone-mediated loss of responsiveness of functionally restricted opiate sensitive mechanisms in the central nervous system.	Corticosterone	72-86	proopiomelanocortin	Homo sapiens	47-51
6589024-4	1984	In the presence of dexamethasone (2.6 X 10(-5)M) or corticosterone (2.9 X 10(-5) M), the effects of NA and AII, in enhancing prostaglandin synthesis and producing renal vasoconstriction, were reduced.	Corticosterone	52-66	angiotensinogen	Rattus norvegicus	107-110
6589024-9	1984	These data indicate that in Tyrode-perfused rat kidney the glucocorticoids dexamethasone and corticosterone exert a differential effect on the renal vascular reactivity to vasoactive hormones, and that their inhibitory effect on NA and AII-induced renal vasoconstriction appears to be unrelated to prostaglandin synthesis.	Corticosterone	93-107	angiotensinogen	Rattus norvegicus	236-239
6466731-6	1984	Whether transcortin was free or bound to corticosterone, the same aspect was observed.	Corticosterone	41-55	serpin family A member 6	Homo sapiens	8-19
6328122-0	1984	ACTH sensitivity of isolated human pathological adrenocortical cells: variability of responses in aldosterone, corticosterone, deoxycorticosterone and cortisol production.	Corticosterone	111-125	proopiomelanocortin	Homo sapiens	0-4
6328122-3	1984	Adrenocortical cells derived from micronodular hyperplasia causing Cushing"s syndrome and cells from cortisol producing adenoma displayed predominantly cortisol and corticosterone secretion both under basal conditions and following stimulation with ACTH.	Corticosterone	165-179	proopiomelanocortin	Homo sapiens	249-253
6327457-4	1984	A single injection of 8 IU of mammalian ACTH into juvenile alligators resulted in a significant increase in corticosterone levels by 1 hr; hormone levels remained elevated for 24 hr, returning to baseline by 48 hr.	Corticosterone	108-122	proopiomelanocortin	Homo sapiens	40-44
6733543-1	1984	Modulation of CA1 field potential amplitudes by normal and stress concentrations of corticosterone (CT) was observed in hippocampal slice preparations from adrenalectomized rats.	Corticosterone	84-98	carbonic anhydrase 1	Rattus norvegicus	14-17
6733543-1	1984	Modulation of CA1 field potential amplitudes by normal and stress concentrations of corticosterone (CT) was observed in hippocampal slice preparations from adrenalectomized rats.	Corticosterone	100-102	carbonic anhydrase 1	Rattus norvegicus	14-17
6728778-6	1984	Serum concentrations of corticosterone and T3 were higher in BSX than sham-operated birds at all ages.	Corticosterone	24-38	brain specific homeobox	Gallus gallus	61-64
6377108-8	1984	We conclude that (1) a receptor readily shared by aldosterone, corticosterone, 18-OH-DOC and DOC, but not by dihydrotestosterone, is widely distributed throughout the CNS, (2) a receptor shared by aldosterone and 18-OH-DOC, but not by corticosterone may be present in hippocampal areas CA1 and CA2, (3) that both these as well as the receptor accepting dihydrotestosterone can be located within the same cell.	Corticosterone	63-77	carbonic anhydrase 1	Rattus norvegicus	286-289
6546571-2	1984	Both dexamethasone and corticosterone had rapid inhibitory effects on POMC transcription in the anterior lobe but not in the intermediate lobe of the pituitary.	Corticosterone	23-37	proopiomelanocortin	Rattus norvegicus	70-74
6377108-4	1984	Traces of radioactivity were, furthermore, retained in areas CA1 and CA2 and the dentate gyrus in rats exposed to corticosterone, but not to 18-OH-DOC, prior to [3H]aldosterone.	Corticosterone	114-128	carbonic anhydrase 1	Rattus norvegicus	61-64
6377108-8	1984	We conclude that (1) a receptor readily shared by aldosterone, corticosterone, 18-OH-DOC and DOC, but not by dihydrotestosterone, is widely distributed throughout the CNS, (2) a receptor shared by aldosterone and 18-OH-DOC, but not by corticosterone may be present in hippocampal areas CA1 and CA2, (3) that both these as well as the receptor accepting dihydrotestosterone can be located within the same cell.	Corticosterone	63-77	carbonic anhydrase 2	Rattus norvegicus	294-297
6377108-4	1984	Traces of radioactivity were, furthermore, retained in areas CA1 and CA2 and the dentate gyrus in rats exposed to corticosterone, but not to 18-OH-DOC, prior to [3H]aldosterone.	Corticosterone	114-128	carbonic anhydrase 2	Rattus norvegicus	69-72
6377108-8	1984	We conclude that (1) a receptor readily shared by aldosterone, corticosterone, 18-OH-DOC and DOC, but not by dihydrotestosterone, is widely distributed throughout the CNS, (2) a receptor shared by aldosterone and 18-OH-DOC, but not by corticosterone may be present in hippocampal areas CA1 and CA2, (3) that both these as well as the receptor accepting dihydrotestosterone can be located within the same cell.	Corticosterone	235-249	carbonic anhydrase 1	Rattus norvegicus	286-289
6377108-8	1984	We conclude that (1) a receptor readily shared by aldosterone, corticosterone, 18-OH-DOC and DOC, but not by dihydrotestosterone, is widely distributed throughout the CNS, (2) a receptor shared by aldosterone and 18-OH-DOC, but not by corticosterone may be present in hippocampal areas CA1 and CA2, (3) that both these as well as the receptor accepting dihydrotestosterone can be located within the same cell.	Corticosterone	235-249	carbonic anhydrase 2	Rattus norvegicus	294-297
6321219-8	1984	Detailed analysis of hippocampal influence on urethane stimulated plasma corticosterone levels showed increased plasma corticosterone levels following stimulation of CA1.	Corticosterone	73-87	carbonic anhydrase 1	Rattus norvegicus	166-169
6320808-5	1984	When Wistar-rat hepatocytes were incubated with corticosterone for 6 h there was a 19% increase in triacylglycerol synthesis, and a 52% increase if vasopressin was added 30 min before the end of the incubation.	Corticosterone	48-62	arginine vasopressin	Rattus norvegicus	148-159
6441620-2	1984	Corticosterone produced an important decrease in amplitude of the population spike activity elicited in CA1 field through commissural stimulation as well as through stimulation of the perforant path.	Corticosterone	0-14	carbonic anhydrase 1	Mus musculus	104-107
6690273-7	1984	Finally, the declines in glucocorticoid receptor number were reversible; receptor concentrations returned to normal levels within 1 week after the cessation of treatment with exogenous corticosterone.	Corticosterone	185-199	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	25-48
6320679-1	1984	To determine the intrarenal distribution of extravascular corticosteroid-binding globulin- (CBG) like sites, we measured the specific binding of [3H]corticosterone to supernatants prepared from papilla-inner medulla, outer medulla, and cortex from adrenalectomized rats.	Corticosterone	149-163	serpin family A member 6	Rattus norvegicus	92-95
6321219-9	1984	In contrast, stimulation of CA3, dentate (includes CA4) and the subiculum produced significant decreases in plasma corticosterone levels.	Corticosterone	115-129	carbonic anhydrase 3	Rattus norvegicus	28-31
6321219-9	1984	In contrast, stimulation of CA3, dentate (includes CA4) and the subiculum produced significant decreases in plasma corticosterone levels.	Corticosterone	115-129	carbonic anhydrase 4	Rattus norvegicus	51-54
6324149-5	1984	Ang II stimulated beta END-LI release was blocked by cycloheximide and decreased by corticosterone (5 nmol/l).	Corticosterone	84-98	angiotensinogen	Rattus norvegicus	0-6
6320679-7	1984	In addition, given the higher levels of extravascular than intravascular CBG and the recurrent vascular architecture of the renal medulla-papilla, a countercurrent exchange model is proposed for renewable sequestration of corticosterone in the region.	Corticosterone	222-236	serpin family A member 6	Rattus norvegicus	73-76
6325319-4	1984	GH also interacted with 10(-6) and 10(-5) M dibutyryl cyclic AMP (dbcAMP) to augment synthesis of corticosterone.	Corticosterone	98-112	gonadotropin releasing hormone receptor	Rattus norvegicus	0-2
6227474-4	1983	However, due to the very high affinity of CBG for corticosterone at 4 C, this slight contamination resulted in significant alterations in the apparent affinity of steroids competing for aldosterone-binding sites.	Corticosterone	50-64	serpin family A member 6	Rattus norvegicus	42-45
6323870-14	1984	The aldosterone and corticosterone outputs were also stimulated by the combined presence of vasopressin and ACTH in the incubation medium; a maximal effect was observed between 6 and 8 days of treatment.	Corticosterone	20-34	arginine vasopressin	Rattus norvegicus	92-103
6323870-15	1984	Vasopressin (10(-11) M) + ACTH (10(-11) M) stimulated the aldosterone output 7-fold and that of corticosterone by 18-fold.	Corticosterone	96-110	arginine vasopressin	Rattus norvegicus	0-11
6323870-19	1984	In addition, together with ACTH vasopressin stimulates the aldosterone and corticosterone output both in vivo and in vitro in primary cell cultures.	Corticosterone	75-89	arginine vasopressin	Rattus norvegicus	32-43
6368985-4	1984	It is postulated that the CBG-like molecules participate in the cellular uptake process of corticosterone, thereby modulating the feedback signal of this steroid on pituitary function.	Corticosterone	91-105	serpin family A member 6	Rattus norvegicus	26-29
6318854-1	1983	It has been disclosed that beta-endorphin exerts marked effect on the secretion of ACTH, prolactin, corticosterone, aldosterone and somatotrophin formation in the pituitary but does not produce any effect on blood thyrotropin.	Corticosterone	100-114	proopiomelanocortin	Homo sapiens	27-41
6318854-3	1983	At the 60th minute after beta-endorphin injection the content of prolactin, corticosterone and aldosterone in the blood dropped to the control level, while ACTH content remained significantly higher than in intact animals.	Corticosterone	76-90	proopiomelanocortin	Homo sapiens	25-39
6227474-11	1983	It is concluded that the high affinity aldosterone receptor of rat brain, which had been identified in preliminary studies as a mineralocorticoid receptor, may bind either corticosterone or aldosterone in vivo.	Corticosterone	172-186	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	128-154
6140073-2	1983	Corticosterone treatment resulted in an age-dependent increase in glutamine synthetase activity.	Corticosterone	0-14	glutamate-ammonia ligase	Rattus norvegicus	66-86
6628329-7	1983	The occupancy of this site in vivo may depend on the relative tissue concentrations of aldosterone or corticosterone, which, in turn, are modulated by the levels of extravascular transcortin.	Corticosterone	102-116	serpin family A member 6	Rattus norvegicus	179-190
6354838-2	1983	Particular emphasis was placed on the effects of hypophysectomy, pituitary transplantation, and treatment with corticosterone (CORT).	Corticosterone	111-125	CORT	Gallus gallus	127-131
6311512-7	1983	In contrast, corticosterone exposure caused a dose-related enhancement of E-GHRF-stimulated release above that accounted for by the increase in total GH content alone.	Corticosterone	13-27	growth hormone releasing hormone	Rattus norvegicus	76-80
6311512-11	1983	These studies indicate that long term (4-day) exposure to corticosterone increases net GH synthesis and E-GHRF-stimulated release, but that acute (4 h) exposure inhibits stimulated release.	Corticosterone	58-72	growth hormone releasing hormone	Rattus norvegicus	106-110
6311521-0	1983	Influence of the frequency of ovine corticotropin-releasing factor administration on adrenocorticotropin and corticosterone secretion in the rat.	Corticosterone	109-123	corticotropin releasing hormone	Rattus norvegicus	36-66
6310242-2	1983	The major findings were that: (1) alpha-MSH stimulated corticosterone production in glomerulosa cells from from normal animals at concentrations of about 10(-10) mol/l, but other steroids, including aldosterone, were not significantly stimulated until levels of 10(-7) mol/l were used.	Corticosterone	55-69	proopiomelanocortin	Rattus norvegicus	34-43
6355389-1	1983	Using [3H]corticosterone as a probe, corticosteroid-binding protein (CBP) was detected in eight out of eight isolates of Candida albicans, of both A and B serotypes.	Corticosterone	10-24	CREB binding protein	Mus musculus	69-72
6310242-8	1983	Bromocriptine treatment (which depresses the level of alpha-MSH in circulating plasma) and metoclopramide (which enhances it) respectively increased and decreased the sensitivity of the response of corticosterone to alpha-MSH in subsequently incubated glomerulosa cells, but had no effect on aldosterone.	Corticosterone	198-212	proopiomelanocortin	Rattus norvegicus	54-63
6853674-5	1983	Corticosterone was used as the model corticosteroid, since this compound binds to CBG with the same affinity as does cortisol, and the brain extraction of corticosterone is more readily measured in vivo than is the brain extraction of cortisol.	Corticosterone	0-14	serpin family A member 6	Rattus norvegicus	82-85
6310242-8	1983	Bromocriptine treatment (which depresses the level of alpha-MSH in circulating plasma) and metoclopramide (which enhances it) respectively increased and decreased the sensitivity of the response of corticosterone to alpha-MSH in subsequently incubated glomerulosa cells, but had no effect on aldosterone.	Corticosterone	198-212	proopiomelanocortin	Rattus norvegicus	216-225
6310242-13	1983	Corticosterone production is stimulated by alpha-MSH in cells from normal animals at concentrations within the normal range for circulating plasma (approximately 3 X 10(-10) mol/l), while aldosterone is stimulated by similar concentrations of alpha-MSH in cells from sodium depleted animals.	Corticosterone	0-14	proopiomelanocortin	Rattus norvegicus	43-52
6860665-8	1983	We found that corticosterone uptake was temperature-sensitive, and an apparent phase-transition effect on the rate of uptake was seen to occur at approximately 16 degrees C. Treatment of the vesicles with phospholipase A2 and the sulfhydryl group attacker, p-chloromercuriphenylsulfonate, inhibited corticosterone uptake.	Corticosterone	14-28	phospholipase A2 group IB	Homo sapiens	205-221
6602859-0	1983	Biphasic inhibition of bioactive hypothalamic corticotrophin releasing factor secretion in vitro by corticosterone and prevention of the second phase by various steroids.	Corticosterone	100-114	corticotropin releasing hormone	Rattus norvegicus	46-77
6602859-2	1983	The addition of corticosterone (10(-7) mol/l) for 30 min to the incubation medium inhibited immediately the release of bioactive corticotrophin releasing factor (CRF) by tissue induced by serotonin (2.6 X 10(-8) mol/l).	Corticosterone	16-30	corticotropin releasing hormone	Rattus norvegicus	129-160
6306667-6	1983	During development corticosterone triggers the synthesis, or at least the appearance of gastrin receptors.	Corticosterone	19-33	gastrin	Rattus norvegicus	88-95
6684831-1	1983	Amount of corticosterone-binding sites in transcortin from blood plasma of intact rats constituted 2960 fmole/mg of protein, in the animals with stress reaction caused by immobilization within 24 hrs--1630 fmole/mg.	Corticosterone	10-24	serpin family A member 6	Rattus norvegicus	42-53
6684831-2	1983	Dissociation constants of the complex corticosterone-transcortin were 4.6 nM and 9.3 nM, respectively.	Corticosterone	38-52	serpin family A member 6	Rattus norvegicus	53-64
6403351-2	1983	Aldose reductase catalyzed the reduction of the aldehydes derived from cortisol and corticosterone at about the same rate, whereas aldehyde reductase preferentially acted on the aldehydes derived from 17-deoxycorticosteroids.	Corticosterone	84-98	aldo-keto reductase family 1 member B	Homo sapiens	0-16
6833270-7	1983	Rat brain cytosolic receptors for corticosterone and dexamethasone elute from DEAE-Sephadex A-50 anion exchange columns at 0.3 M NaCl in the presence of stabilizing sodium molybdate and at 0.15 M NaCl and/or in the buffer wash when heat-activated, thus exhibiting the characteristic activation pattern of rat liver cytosolic glucocorticoid receptor.	Corticosterone	34-48	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	325-348
6303505-5	1983	Treatment with anti-AChR increased basal ACTH and corticosterone (CS) levels (by approximately two-fold) but completely inhibited the responses of these hormones and PRL to ether stress.	Corticosterone	50-64	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	20-24
6303505-5	1983	Treatment with anti-AChR increased basal ACTH and corticosterone (CS) levels (by approximately two-fold) but completely inhibited the responses of these hormones and PRL to ether stress.	Corticosterone	66-68	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	20-24
6300679-8	1983	I report here that pretreatment by 1-deaminopenicillamine, 2-(O-methyl)tyrosine arginine-vasopressin (dPTyr(Me)AVP), a potent antagonist of the vasopressor, behavioural and ACTH-releasing properties of AVP, does not modify the ACTH and corticosterone secretion induced by exposure to a novel environment, but totally inhibits the increase of ACTH and corticosterone levels induced by AVP.	Corticosterone	236-250	arginine vasopressin	Rattus norvegicus	80-100
6300679-8	1983	I report here that pretreatment by 1-deaminopenicillamine, 2-(O-methyl)tyrosine arginine-vasopressin (dPTyr(Me)AVP), a potent antagonist of the vasopressor, behavioural and ACTH-releasing properties of AVP, does not modify the ACTH and corticosterone secretion induced by exposure to a novel environment, but totally inhibits the increase of ACTH and corticosterone levels induced by AVP.	Corticosterone	236-250	arginine vasopressin	Rattus norvegicus	111-114
6300679-8	1983	I report here that pretreatment by 1-deaminopenicillamine, 2-(O-methyl)tyrosine arginine-vasopressin (dPTyr(Me)AVP), a potent antagonist of the vasopressor, behavioural and ACTH-releasing properties of AVP, does not modify the ACTH and corticosterone secretion induced by exposure to a novel environment, but totally inhibits the increase of ACTH and corticosterone levels induced by AVP.	Corticosterone	351-365	arginine vasopressin	Rattus norvegicus	80-100
6300679-8	1983	I report here that pretreatment by 1-deaminopenicillamine, 2-(O-methyl)tyrosine arginine-vasopressin (dPTyr(Me)AVP), a potent antagonist of the vasopressor, behavioural and ACTH-releasing properties of AVP, does not modify the ACTH and corticosterone secretion induced by exposure to a novel environment, but totally inhibits the increase of ACTH and corticosterone levels induced by AVP.	Corticosterone	351-365	arginine vasopressin	Rattus norvegicus	111-114
6404194-9	1983	Corticosterone replacement was found to maintain the enzyme activities along with serum prolactin and corticosterone at control levels.	Corticosterone	0-14	prolactin	Rattus norvegicus	88-97
6339060-5	1983	(2) Plasma corticosterone levels varied inversely to those of GH, increasing to twice the control values during G1 and were back to physiological levels when synchronized hepatocytes entered the S phase.	Corticosterone	11-25	gonadotropin releasing hormone receptor	Rattus norvegicus	62-64
6603348-1	1983	The effect of bilateral adrenal medullectomy on the activity of catecholamine degrading enzymes--catechol-o-methyl transferase (COMT) and monoamino oxidase (MAO)--in adrenal cortex and on the level of corticosterone in plasma was studied in the rats subjected either to a single (2.5 h) or repeated (2.5 h daily for 150 days omitting Saturdays and Sundays) immobilization stress.	Corticosterone	201-215	catechol-O-methyltransferase	Rattus norvegicus	128-132
6603348-1	1983	The effect of bilateral adrenal medullectomy on the activity of catecholamine degrading enzymes--catechol-o-methyl transferase (COMT) and monoamino oxidase (MAO)--in adrenal cortex and on the level of corticosterone in plasma was studied in the rats subjected either to a single (2.5 h) or repeated (2.5 h daily for 150 days omitting Saturdays and Sundays) immobilization stress.	Corticosterone	201-215	monoamine oxidase A	Rattus norvegicus	157-160
6822123-5	1983	Reserpinization leads to selective increases in brain angiotensinogen which are shown to be attributable to adrenal corticosterone secretion.	Corticosterone	116-130	angiotensinogen	Rattus norvegicus	54-69
6843116-4	1983	Moreover, pre-incubation of the SPM with phospholipase A2 or phospholipase C totally destroys the membrane binding of corticosterone and testosterone, but the binding of estradiol and progesterone remains intact.	Corticosterone	118-132	phospholipase A2 group IB	Rattus norvegicus	41-57
6131369-7	1983	At doses 10(-6) and 10(-5) M, 20-min infusions of synthetic porcine or chicken VIP elicited a significant increase in corticosterone and aldosterone production by perifused frog adrenals, in a dose-dependent manner.	Corticosterone	118-132	vasoactive intestinal peptide	Gallus gallus	79-82
6298090-4	1983	Competition studies indicate that pituitary transcortin modulates interaction of corticosterone with receptor binding sites and, hence, may interfere with steroid translocation to the nucleus.	Corticosterone	81-95	serpin family A member 6	Rattus norvegicus	44-55
6295691-9	1983	Factors which increase angiotensin II levels, such as sodium restriction, isometric exercise and angiotensin infusion, selectively increase 18-OHB and aldosterone, suggesting that angiotensin II increases 18-OHB and aldosterone secretion, in part, by modulation of the 18-hydroxylation reaction involved in conversion of corticosterone into 18-OHB.	Corticosterone	321-335	angiotensinogen	Homo sapiens	23-37
6295691-9	1983	Factors which increase angiotensin II levels, such as sodium restriction, isometric exercise and angiotensin infusion, selectively increase 18-OHB and aldosterone, suggesting that angiotensin II increases 18-OHB and aldosterone secretion, in part, by modulation of the 18-hydroxylation reaction involved in conversion of corticosterone into 18-OHB.	Corticosterone	321-335	angiotensinogen	Homo sapiens	180-194
6826048-6	1983	Adrenal corticosterone, cortisol, progesterone, and testosterone concentrations reached a peak 1 day after hatching, and decreased thereafter in both sexes.	Corticosterone	8-22	inactive tyrosine-protein kinase PEAK1	Anas platyrhynchos	90-96
6756162-2	1982	In intact rats, only an extremely high dose of exogenous angiotensin II imitated the stimulatory effects of polyethylene glycol-induced edema on the conversions of deoxycorticosterone and corticosterone to 18-hydroxycorticosterone and aldosterone.	Corticosterone	169-183	angiotensinogen	Rattus norvegicus	57-71
6840671-5	1983	Corticosterone administration resulted in a significant decline in AchE activity of the cortex, the hypothalamus and the adrenal but failed to affect the adenohypophysis AchE level.	Corticosterone	0-14	acetylcholinesterase	Rattus norvegicus	67-71
6840671-7	1983	It was concluded from this study that corticosterone might mediate the stress effect on AchE activity.	Corticosterone	38-52	acetylcholinesterase	Rattus norvegicus	88-92
6306499-7	1983	corticosterone (5 nM) decreased Ang II (10 nM) mediated ACTH release to control values while dibenzyline (10 microM), an alpha-adrenergic antagonist and cyproheptadine (10 microM), a serotonin antagonist did not alter the stimulation of ACTH by Ang II.	Corticosterone	0-14	angiotensinogen	Rattus norvegicus	32-38
6306499-7	1983	corticosterone (5 nM) decreased Ang II (10 nM) mediated ACTH release to control values while dibenzyline (10 microM), an alpha-adrenergic antagonist and cyproheptadine (10 microM), a serotonin antagonist did not alter the stimulation of ACTH by Ang II.	Corticosterone	0-14	angiotensinogen	Rattus norvegicus	245-251
6306499-8	1983	This study suggests (1) the N-terminal amino acids of Ang II are important for the ACTH stimulatory action of Ang II, (2) [Sar1,Ala8]Ang II and [Sar1,Gly8]Ang II are specific Ang II antagonists at the pituitary level towards the ACTH releasing effect of Ang II, and (3) corticosterone inhibits the in vitro pituitary ACTH release by Ang II while dibenzyline and cyproheptadine have no effect.	Corticosterone	270-284	angiotensinogen	Rattus norvegicus	54-60
6306499-8	1983	This study suggests (1) the N-terminal amino acids of Ang II are important for the ACTH stimulatory action of Ang II, (2) [Sar1,Ala8]Ang II and [Sar1,Gly8]Ang II are specific Ang II antagonists at the pituitary level towards the ACTH releasing effect of Ang II, and (3) corticosterone inhibits the in vitro pituitary ACTH release by Ang II while dibenzyline and cyproheptadine have no effect.	Corticosterone	270-284	angiotensinogen	Rattus norvegicus	110-116
6306499-8	1983	This study suggests (1) the N-terminal amino acids of Ang II are important for the ACTH stimulatory action of Ang II, (2) [Sar1,Ala8]Ang II and [Sar1,Gly8]Ang II are specific Ang II antagonists at the pituitary level towards the ACTH releasing effect of Ang II, and (3) corticosterone inhibits the in vitro pituitary ACTH release by Ang II while dibenzyline and cyproheptadine have no effect.	Corticosterone	270-284	angiotensinogen	Rattus norvegicus	110-116
6306499-8	1983	This study suggests (1) the N-terminal amino acids of Ang II are important for the ACTH stimulatory action of Ang II, (2) [Sar1,Ala8]Ang II and [Sar1,Gly8]Ang II are specific Ang II antagonists at the pituitary level towards the ACTH releasing effect of Ang II, and (3) corticosterone inhibits the in vitro pituitary ACTH release by Ang II while dibenzyline and cyproheptadine have no effect.	Corticosterone	270-284	angiotensinogen	Rattus norvegicus	110-116
6306499-8	1983	This study suggests (1) the N-terminal amino acids of Ang II are important for the ACTH stimulatory action of Ang II, (2) [Sar1,Ala8]Ang II and [Sar1,Gly8]Ang II are specific Ang II antagonists at the pituitary level towards the ACTH releasing effect of Ang II, and (3) corticosterone inhibits the in vitro pituitary ACTH release by Ang II while dibenzyline and cyproheptadine have no effect.	Corticosterone	270-284	angiotensinogen	Rattus norvegicus	110-116
6306499-8	1983	This study suggests (1) the N-terminal amino acids of Ang II are important for the ACTH stimulatory action of Ang II, (2) [Sar1,Ala8]Ang II and [Sar1,Gly8]Ang II are specific Ang II antagonists at the pituitary level towards the ACTH releasing effect of Ang II, and (3) corticosterone inhibits the in vitro pituitary ACTH release by Ang II while dibenzyline and cyproheptadine have no effect.	Corticosterone	270-284	angiotensinogen	Rattus norvegicus	110-116
6306499-8	1983	This study suggests (1) the N-terminal amino acids of Ang II are important for the ACTH stimulatory action of Ang II, (2) [Sar1,Ala8]Ang II and [Sar1,Gly8]Ang II are specific Ang II antagonists at the pituitary level towards the ACTH releasing effect of Ang II, and (3) corticosterone inhibits the in vitro pituitary ACTH release by Ang II while dibenzyline and cyproheptadine have no effect.	Corticosterone	270-284	angiotensinogen	Rattus norvegicus	110-116
7149018-2	1982	When blinded pups were raised by intact natural mothers, the peak time of corticosterone rhythm appeared near the time of light-dark (LD) transition, which was close to that of mothers, and then free-ran.	Corticosterone	74-88	RAN, member RAS oncogene family	Rattus norvegicus	139-142
6759355-0	1982	Effect of calcium upon insulin inhibition induced by corticosterone in isolated Langerhans islets.	Corticosterone	53-67	insulin	Homo sapiens	23-30
7155298-3	1982	This reduction was observed whether corticosterone or dexamethasone was employed as competitor to determine nonspecific binding, thus eliminating transcortin as the cause of the corticosterone effect on binding.	Corticosterone	178-192	serpin family A member 6	Rattus norvegicus	146-157
6127203-1	1982	Administration of corticosterone (10 mg/kg, ip, twice daily for 3 days) to mice during the second week of postnatal development led to an increase of tyrosine hydroxylase (TH) activity in the locus coeruleus, but not in the substantia nigra.	Corticosterone	18-32	tyrosine hydroxylase	Mus musculus	150-170
6127203-1	1982	Administration of corticosterone (10 mg/kg, ip, twice daily for 3 days) to mice during the second week of postnatal development led to an increase of tyrosine hydroxylase (TH) activity in the locus coeruleus, but not in the substantia nigra.	Corticosterone	18-32	tyrosine hydroxylase	Mus musculus	172-174
6127203-5	1982	Cortexolone and progesterone, two antiglucocorticoids that can bind to the cytosol receptor, were found to abolish the effect of corticosterone in increasing TH activity.	Corticosterone	129-143	tyrosine hydroxylase	Mus musculus	158-160
7150966-6	1982	A large portion (approximately 75%) of the transcortin-like [3H]corticosterone binding protein was located in the interstitial space between the sheath and the ganglionic cells.	Corticosterone	64-78	serpin family A member 6	Rattus norvegicus	43-54
7128523-8	1982	Using a liver slice system to assess CBG production in vitro, livers from 14-day-old hyperthyroid pups produced 4.77 ng corticosterone bound/g liver, while livers from euthyroid pups produced no CBG.	Corticosterone	120-134	serpin family A member 6	Homo sapiens	37-40
6127116-4	1982	The hormonal specificity was demonstrated by the relative potencies of several glucocorticoids and sex steroids: hydrocortisone and corticosterone increased gamma-glutamyltransferase activity while tetrahydrocorticosterone and all sex steroids tested were ineffective.	Corticosterone	132-146	gamma-glutamyltransferase 1	Rattus norvegicus	157-182
6897422-2	1982	Statistically significant augmentation by testosterone and medroxyprogesterone was observed at concentrations of 10(-7) and 10(-8) M. Progesterone enhanced MIS activity at a concentration of 10(-6) M. By contrast, dihydrotestosterone, estradiol, and corticosterone at concentrations of 10(-9) to 10(-5) M produced no significant effect on MIS activity.	Corticosterone	250-264	anti-Mullerian hormone	Homo sapiens	156-159
6214412-7	1982	At higher doses, MAO-B inhibition by deprenil (40 mg/kg) induced a moderate but sustained increase in corticosterone levels, while MAO-A inhibition by clorgyline (5, 10, 20 mg/kg) resulted in a large and sharp rise.	Corticosterone	102-116	monoamine oxidase B	Rattus norvegicus	17-22
6294763-3	1982	Corticosterone administration inhibited BAP metabolism 53%.	Corticosterone	0-14	prohibitin 2	Rattus norvegicus	40-43
6294763-5	1982	However, corticosterone in vitro inhibited BAP metabolism in a dose-related fashion in washed microsomes from untreated rats.	Corticosterone	9-23	prohibitin 2	Rattus norvegicus	43-46
6286755-8	1982	Because histamine interaction with H1 receptors causes the release of adrenocorticotropic hormone (ACTH), we examined the effects of ACTH and corticosterone in this system and found that both could mimick the effect of histamine.	Corticosterone	142-156	pro-opiomelanocortin-alpha	Mus musculus	70-97
6286755-8	1982	Because histamine interaction with H1 receptors causes the release of adrenocorticotropic hormone (ACTH), we examined the effects of ACTH and corticosterone in this system and found that both could mimick the effect of histamine.	Corticosterone	142-156	pro-opiomelanocortin-alpha	Mus musculus	99-103
6806448-8	1982	Optic nerve cytosol fractions displayed substantial high-affinity binding of both dexamethasone (DEX) and corticosterone (CORT) that, like GPDH, was elevated approximately two fold in degenerating nerves.	Corticosterone	106-120	glycerol-3-phosphate dehydrogenase 1	Rattus norvegicus	139-143
7062053-4	1982	Corticosterone and dexamethasone increased ODC activity in the liver and brain areas in a dose-dependent manner, dexamethasone being more active than corticosterone in all tissues.	Corticosterone	0-14	ornithine decarboxylase 1	Rattus norvegicus	43-46
6177693-4	1982	Daily treatment of hypophysectomized rats with 5 alpha-dihydrotestosterone, corticosterone, thyroxine, and growth hormone for 8 days caused about 80% recovery in the hepatic content of alpha 2u-globulin and its corresponding mRNA as determined by radioimmunoassay, in vitro translation, and liquid hybridization with a cloned cDNA probe.	Corticosterone	76-90	alpha2u globulin	Rattus norvegicus	185-202
6289151-8	1982	Since AChE activity is also present in nonneuronal cells, the observed alterations caused by corticosterone may reflect glial cell responses to the hormone.	Corticosterone	93-107	acetylcholinesterase (Cartwright blood group)	Gallus gallus	6-10
7113584-1	1982	Progesterone and corticosterone have a similar effect on the production of growth hormone (GH) and prolactin (Prl) by pituitary tumour cells (GH3 cells) in culture.	Corticosterone	17-31	gonadotropin releasing hormone receptor	Rattus norvegicus	75-89
7113584-1	1982	Progesterone and corticosterone have a similar effect on the production of growth hormone (GH) and prolactin (Prl) by pituitary tumour cells (GH3 cells) in culture.	Corticosterone	17-31	gonadotropin releasing hormone receptor	Rattus norvegicus	91-93
7113584-1	1982	Progesterone and corticosterone have a similar effect on the production of growth hormone (GH) and prolactin (Prl) by pituitary tumour cells (GH3 cells) in culture.	Corticosterone	17-31	prolactin	Rattus norvegicus	99-108
6291824-11	1982	However, the measurement of ACTH-stimulated corticosterone levels may be useful, since the gene responsible for 17-OHDS seems to be expressed hormonally in the heterozygous state.	Corticosterone	44-58	OHDS	Homo sapiens	115-119
6281486-5	1982	ASF increased the conversion of corticosterone to aldosterone like ACTH and beta-LPH.	Corticosterone	32-46	serine and arginine rich splicing factor 1	Homo sapiens	0-3
7062053-4	1982	Corticosterone and dexamethasone increased ODC activity in the liver and brain areas in a dose-dependent manner, dexamethasone being more active than corticosterone in all tissues.	Corticosterone	150-164	ornithine decarboxylase 1	Rattus norvegicus	43-46
6281486-5	1982	ASF increased the conversion of corticosterone to aldosterone like ACTH and beta-LPH.	Corticosterone	32-46	proopiomelanocortin	Homo sapiens	67-71
6281486-5	1982	ASF increased the conversion of corticosterone to aldosterone like ACTH and beta-LPH.	Corticosterone	32-46	proopiomelanocortin	Homo sapiens	76-84
6281486-7	1982	The present study suggests ASF shares a common rate-limiting final pathway of steroidogenesis, which may be the step between corticosterone to aldosterone, with ACTH, A II and beta-LPH.	Corticosterone	125-139	serine and arginine rich splicing factor 1	Homo sapiens	27-30
6288594-1	1982	Stimulation of corticosterone and aldosterone production in rat adrenal decapsular and capsular cells respectively by alpha- and beta-melanotropins (alpha- and beta-MSH) have been investigated.	Corticosterone	15-29	proopiomelanocortin	Rattus norvegicus	149-168
6124362-2	1982	Prolactin (PRL) has been previously associated with adrenal secretion of either corticosterone, progesterone, or aldosterone.	Corticosterone	80-94	prolactin	Mus musculus	0-9
6284134-1	1982	The activities of neutral cholesterol esterase and acyl-CoA : cholesterol acyltransferase in rat adrenal gland were measured at various time intervals over 24 h. The activity of cholesterol esterase displayed diurnal rhythm, with a major peak at the onset of darkness coinciding with the peak in the diurnal rhythm of plasma corticosterone concentration.	Corticosterone	325-339	carboxyl ester lipase	Rattus norvegicus	178-198
7056844-1	1982	Stimulation of aldosterone and corticosterone production by pituitary peptides structurally or biosynthetically related to ACTH was investigated in suspensions of isolated rat adrenal glomerulosa and fasciculata cells, respectively.	Corticosterone	31-45	proopiomelanocortin	Homo sapiens	123-127
7056844-4	1982	Stimulation of corticosterone production by beta LPH preparations generally paralleled their aldosterone-stimulating activity, and most steroidogenic activity could be accounted for by immunoreactive ACTH, as determined in two ACTH RIAs.	Corticosterone	15-29	proopiomelanocortin	Homo sapiens	44-52
7056844-5	1982	Synthetic human beta LPH-(37-58), which contains the 47-53 heptapeptide sequence common to beta LPH and ACTH, had aldosterone- and corticosterone-stimulating activities similar to those of equimolar concentrations of beta LPH, whereas synthetic fragments of the COOH-terminal (61-91) portion of beta LPH had no steroidogenic activity.	Corticosterone	131-145	proopiomelanocortin	Homo sapiens	16-24
7056849-3	1982	The blocking effect of met-enkephalin on the rate of aldosterone, deoxycorticosterone, and corticosterone release was significant at a concentration as low as 10(-11) M (P less than 0.001, P less than 0.01, and P less than 0.001, respectively).	Corticosterone	71-85	proopiomelanocortin	Homo sapiens	23-37
7056849-4	1982	Dose-dependent inhibition of steroid biosynthesis became more apparent with increasing amounts of met-enkephalin in the incubation medium (10(-11)-10(-5) M); at a concentration of 10(-5) M, met-enkephalin decreased the production of aldosterone by 45%, that of deoxycorticosterone by 51%, and that of corticosterone by 44%.	Corticosterone	266-280	proopiomelanocortin	Homo sapiens	98-112
7056849-6	1982	In a concentration of 10(-5) M, met-enkephalin produced significant decreases in aldosterone (P less than 0.001), deoxycorticosterone (P less than 0.05), and corticosterone (P less than 0.001) production compared to the peak values obtained after stimulation with 0.85 X 10(-10) M ACTH-(1-24).	Corticosterone	119-133	proopiomelanocortin	Homo sapiens	32-46
7087466-3	1982	The relative binding affinity of transcortin to the corticosteroids, as calculated by an in vitro technique, decreased progressively from cortisol, to cortisone, then to corticosterone, then 11-dehydrocorticosterone and, finally to aldosterone.	Corticosterone	170-184	corticosteroid-binding globulin	Oryctolagus cuniculus	33-44
7087466-5	1982	We deduced that, in rabbits: (1) the MCR of a corticosteroid is clearly connected with its binding to a specific protein; (2) in spite of the relatively high binding affinity of transcortin for corticosterone as compared to other species it nevertheless appears unable to significantly protect the steroid against peripheral metabolism; (3) a very effective protection is however, induced, by raising a specific antibody with a high binding affinity for corticosterone.	Corticosterone	194-208	corticosteroid-binding globulin	Oryctolagus cuniculus	178-189
6124362-2	1982	Prolactin (PRL) has been previously associated with adrenal secretion of either corticosterone, progesterone, or aldosterone.	Corticosterone	80-94	prolactin	Mus musculus	11-14
6124362-10	1982	This finding is consistent with a role for PRL in regulating adrenal secretion of either corticosterone or progesterone in the mouse.	Corticosterone	89-103	prolactin	Mus musculus	43-46
6274623-0	1982	In vivo corticotropin-releasing factor-induced secretion of adrenocorticotropin, beta-endorphin, and corticosterone.	Corticosterone	101-115	corticotropin releasing hormone	Rattus norvegicus	8-38
6300381-7	1982	Vasopressin also produced a dose-dependent inhibition of the stimulatory effect of ACTH on the output of corticosterone.	Corticosterone	105-119	arginine vasopressin	Rattus norvegicus	0-11
6958493-5	1982	The radioactivity bound to the cytosolic glucocorticoid receptor protein also appeared to consist of unmetabolised corticosterone and 5 alpha-dihydrocorticosterone.	Corticosterone	115-129	nuclear receptor subfamily 3, group C, member 1	Mus musculus	41-64
6280345-2	1982	Alpha-MSH dose response curves for corticosterone and 18-hydroxydeoxycorticosterone (18-OH-DOC) in subsequently incubated glomerulosa cells gave stimulation at lower concentrations of alpha-MSH (10(-10) moles per litre) than in cells from untreated animals (10(-9) moles per 1).	Corticosterone	35-49	proopiomelanocortin	Rattus norvegicus	0-9
6280345-2	1982	Alpha-MSH dose response curves for corticosterone and 18-hydroxydeoxycorticosterone (18-OH-DOC) in subsequently incubated glomerulosa cells gave stimulation at lower concentrations of alpha-MSH (10(-10) moles per litre) than in cells from untreated animals (10(-9) moles per 1).	Corticosterone	35-49	proopiomelanocortin	Rattus norvegicus	184-193
7284814-6	1981	The hormone specificity of the glucocorticoid receptor in human brain and in rat brain cytosol was compared by competition experiments using unlabelled dexamethasone, betamethasone, cortisol and corticosterone as competitors.	Corticosterone	195-209	nuclear receptor subfamily 3 group C member 1	Homo sapiens	31-54
6274570-12	1981	ACTH produced increases in plasma cortisol, 11-deoxycortisol, corticosterone, deoxycorticosterone, aldosterone, 17 alpha-hydroxyprogesterone and 17 alpha,20 alpha-dihydroxyprogesterone.	Corticosterone	62-76	proopiomelanocortin	Homo sapiens	0-4
6796384-7	1981	In the presence or absence of FSH, treatment with dexamethasone, cortisol, or corticosterone led to significant decreases in the activity of 20 alpha-hydroxysteroid dehydrogenase.	Corticosterone	78-92	aldo-keto reductase family 1, member C3	Rattus norvegicus	141-178
6278481-8	1981	Corticosterone also inhibits VIP-induced cAMP production but at concentrations higher than those of dexamethasone.	Corticosterone	0-14	vasoactive intestinal peptide	Rattus norvegicus	29-32
7311735-0	1981	The influence of oral corticosterone replacement on plasma prolactin levels of adrenalectomized female rats.	Corticosterone	22-36	prolactin	Rattus norvegicus	59-68
7300323-0	1981	The influence of 21-acylation of corticosterone on its binding affinity for corticosteroid-binding globulin.	Corticosterone	33-47	serpin family A member 6	Homo sapiens	76-107
6294390-2	1982	injection of C-terminal octapeptide of cholecystokinin (CCK-8) produced a dose-related increase in plasma corticosterone levels in intact rats, but not in vagotomized ones.	Corticosterone	106-120	cholecystokinin	Rattus norvegicus	39-54
6294390-2	1982	injection of C-terminal octapeptide of cholecystokinin (CCK-8) produced a dose-related increase in plasma corticosterone levels in intact rats, but not in vagotomized ones.	Corticosterone	106-120	cholecystokinin	Rattus norvegicus	56-59
6294390-7	1982	On the other hand, vasoactive intestinal polypeptide (VIP) was found to cause a dose-dependent increase in plasma corticosterone levels when administered centrally, but not after i.p.	Corticosterone	114-128	vasoactive intestinal peptide	Rattus norvegicus	19-52
6294390-7	1982	On the other hand, vasoactive intestinal polypeptide (VIP) was found to cause a dose-dependent increase in plasma corticosterone levels when administered centrally, but not after i.p.	Corticosterone	114-128	vasoactive intestinal peptide	Rattus norvegicus	54-57
6271674-1	1981	Tonin infused intravenously at a rate of 12 micron g/kg/min for 2 hours stimulated aldosterone and corticosterone secretion in conscious rats.	Corticosterone	99-113	kallikrein 1-related peptidase C2	Rattus norvegicus	0-5
6269155-4	1981	Lower doses of CCK-OP (0.5 microgram/kg) elevated corticosterone from 12 microgram/100 ml to 20 microgram/100 ml.	Corticosterone	50-64	cholecystokinin	Homo sapiens	15-18
7195803-2	1981	Cortisol, corticosterone, and the synthetic glucocorticoid analog dexamethasone all induced a 2- to 3-fold increase in accumulation of RBP.	Corticosterone	10-24	retinol binding protein 4	Rattus norvegicus	135-138
6263579-4	1981	[125I]Tyr23,Phe2,Nle4-ACTH-(1-38) was as potent as ACTH in stimulating corticosterone production in isolated rat adrenocortical cells.	Corticosterone	71-85	proopiomelanocortin	Homo sapiens	22-26
6263579-4	1981	[125I]Tyr23,Phe2,Nle4-ACTH-(1-38) was as potent as ACTH in stimulating corticosterone production in isolated rat adrenocortical cells.	Corticosterone	71-85	proopiomelanocortin	Homo sapiens	51-55
6263593-3	1981	Phe2,Nle4-ACTH-(1-38) was found to be indistinguishable from synthetic human ACTH in its ability to stimulate corticosterone production in isolated rat adrenocortical cells.	Corticosterone	110-124	proopiomelanocortin	Homo sapiens	10-14
6262050-5	1981	Dexamethasone decreased testicular LH receptor in control and FSH-treated hypophysectomized rats in doses as low as 10 microgram/day, whereas corticosterone (10 microgram/day) decreased testicular LH receptor in the FSH-treated rats but had no effect in rats not treated with FSH.	Corticosterone	142-156	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	197-208
7291040-2	1981	With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentration of 10(-9) moles per 1, with ED50 at 10(-8) moles per 1.	Corticosterone	85-99	proopiomelanocortin	Rattus norvegicus	135-144
6265351-2	1981	When incubated with adrenal cell suspension at 37 degrees C for 2 hours, urinary ASF induced dose-related increases in both aldosterone and corticosterone production.	Corticosterone	140-154	serine and arginine rich splicing factor 1	Homo sapiens	81-84
6264799-7	1981	In addition, the current studies demonstrated that injection of corticosterone caused a premature increase in both gastrin receptor and antral gastrin levels.	Corticosterone	64-78	gastrin	Rattus norvegicus	115-122
6264799-7	1981	In addition, the current studies demonstrated that injection of corticosterone caused a premature increase in both gastrin receptor and antral gastrin levels.	Corticosterone	64-78	gastrin	Rattus norvegicus	143-150
6265351-6	1981	Like ACTH and AII, urinary ASF increased conversion of corticosterone to aldosterone.	Corticosterone	55-69	serine and arginine rich splicing factor 1	Homo sapiens	27-30
7242852-8	1981	The rise in brainstems PNMT clearly preceded by several hours the circadian rise in plasma corticosterone.	Corticosterone	91-105	phenylethanolamine-N-methyltransferase	Rattus norvegicus	23-27
6263374-0	1981	Paradoxical effects of D-Trp6-LHRH in immature female rats correlated with changes in ACTH, prolactin, and corticosterone levels.	Corticosterone	107-121	gonadotropin releasing hormone 1	Rattus norvegicus	30-34
6781872-13	1981	It also appears that the sensitizing effect of PRL on the prepubertal ovarian P response to gonadotropins is modulated by the adrenal gland through an effect exerted by corticosterone.	Corticosterone	169-183	prolactin	Rattus norvegicus	47-50
7242852-10	1981	In unstressed animals, injection of exogenous corticosterone failed to elevate brainstem PNMT activity, whereas injection of specific inhibitors of PNMT activity significantly elevated plasma corticosterone levels.	Corticosterone	192-206	phenylethanolamine-N-methyltransferase	Rattus norvegicus	148-152
6261179-3	1981	Infusion of 20 or 202 microgram corticosterone over 6 h significantly reduced hypothalamic CRF (corticotropin-releasing factor) content, whereas it did not reduce plasma ACTH levels in normal rats.	Corticosterone	32-46	corticotropin releasing hormone	Rattus norvegicus	96-126
6281421-3	1981	Experiments are presented that compare feedback inhibition of ACTH affected by corticosterone and by adrenal mass.	Corticosterone	79-93	proopiomelanocortin	Homo sapiens	62-66
6778688-7	1981	Nonestrogenic steroids, such as androgens, progestins, and corticosterone, exhibited only minor effects on spontaneous secretion of FSH in either male or female sheep cell culture.	Corticosterone	59-73	follitropin subunit beta	Oryctolagus cuniculus	132-135
7306070-0	1981	Possible involvement of the enhanced tryptophan pyrrolase activity in the corticosterone- and starvation-induced increases in concentrations of nicotinamide-adenine dinucleotides (phosphates) in rat liver.	Corticosterone	74-88	tryptophan 2,3-dioxygenase	Rattus norvegicus	37-57
7004859-2	1981	prolactin, corticosterone, insulin, and triiodothyronine effects on alpha-lactalbumin production.	Corticosterone	11-25	lactalbumin alpha	Homo sapiens	68-85
6116178-0	1981	[Dynamics of cortisol, cortisone, and corticosterone following administration of ACTH in premature and mature newborn infants (author"s transl)].	Corticosterone	38-52	proopiomelanocortin	Homo sapiens	81-85
7305760-4	1981	The concentration of corticosteroids and CBG capacity in the plasma was 250-550 micrograms/l and 250-480 micrograms corticosterone bound per litre, respectively, in rats killed during the last 4 days of gestation.	Corticosterone	116-130	serpin family A member 6	Rattus norvegicus	41-44
20487821-6	1981	The data suggest that the presence of the tyrosine-sulphate-methionine dipeptide is essential in the effects of cholecystokinin octapeptide sulphate ester on the monoamine contents of different brain areas, as well as on the plasma corticosterone level.	Corticosterone	232-246	cholecystokinin	Rattus norvegicus	112-127
7222146-2	1981	The results demonstrate that the uptake of corticosterone, which binds to transcortin, was reduced by addition of serum while uptake of triamcinolone acetonide, which is not bound by transcortin, was unaffected.	Corticosterone	43-57	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	74-85
7196231-3	1981	A quantitative modification of the % of corticosterone bound to CBG was noted.	Corticosterone	40-54	serpin family A member 6	Homo sapiens	64-67
6171467-8	1981	In contrast, the secretion of the total complement of proteins, including AFP, was significantly stimulated by the glucocorticoids, dexamethasone and corticosterone.	Corticosterone	150-164	alpha fetoprotein	Mus musculus	74-77
7037364-1	1981	Cultures of normal rat mammary cells have been developed which produce alpha-lactalbumin (a-LA) for several months in response to physiological levels of corticosterone whereas none is measureable without glucocorticoid.	Corticosterone	154-168	lactalbumin, alpha	Rattus norvegicus	71-88
7007904-0	1981	Influence of corticosterone on the response to gonadotropin-releasing hormone in rats.	Corticosterone	13-27	gonadotropin releasing hormone 1	Rattus norvegicus	47-77
7007904-1	1981	The objective of this study was to determine whether the diurnal rhythm of corticosterone (B) alters the response of the pituitary to gonadotropin-releasing hormone (GnRH).	Corticosterone	75-89	gonadotropin releasing hormone 1	Rattus norvegicus	134-164
7007904-1	1981	The objective of this study was to determine whether the diurnal rhythm of corticosterone (B) alters the response of the pituitary to gonadotropin-releasing hormone (GnRH).	Corticosterone	75-89	gonadotropin releasing hormone 1	Rattus norvegicus	166-170
7435121-1	1980	The effect of corticosterone and dexamethasone on the production of growth hormone and prolactin was studied in rat pituitary tumour cells (GH3-cells) in culture.	Corticosterone	14-28	gonadotropin releasing hormone receptor	Rattus norvegicus	68-82
7470727-1	1980	The inhibitory effects of intracerebroventricular administration of saline on the plasma corticosterone response to ether stress in mice was reduced by Met-enkephalin and enhanced by Leu-enkephalin.	Corticosterone	89-103	pro-opiomelanocortin-alpha	Mus musculus	152-166
7470727-1	1980	The inhibitory effects of intracerebroventricular administration of saline on the plasma corticosterone response to ether stress in mice was reduced by Met-enkephalin and enhanced by Leu-enkephalin.	Corticosterone	89-103	prodynorphin	Mus musculus	183-197
6255013-2	1980	Addition of increasing amounts of K+ and angiotensin II to the incubation media elicited progressive increases in corticosterone production and capsular concentrations of phosphatidic acid, phosphatidyl-inositol, and polyphosphoinositides.	Corticosterone	114-128	angiotensinogen	Rattus norvegicus	41-55
7435121-2	1980	Corticosterone and dexamethasone caused a dose-dependent stimulation of growth hormone synthesis, and the highest concentration (10(-6) mol/l) increased growth hormone levels to 250% of controls.	Corticosterone	0-14	gonadotropin releasing hormone receptor	Rattus norvegicus	72-86
7435121-2	1980	Corticosterone and dexamethasone caused a dose-dependent stimulation of growth hormone synthesis, and the highest concentration (10(-6) mol/l) increased growth hormone levels to 250% of controls.	Corticosterone	0-14	gonadotropin releasing hormone receptor	Rattus norvegicus	153-167
7422070-3	1980	Corticosterone administration restores VIP levels to control values only in the dorsal hippocampus.	Corticosterone	0-14	vasoactive intestinal peptide	Rattus norvegicus	39-42
6262739-8	1980	The ratio of cortisol-related to corticosterone-related products was the same in response in glycosylated and nonglycosylated ACTH.	Corticosterone	33-47	pro-opiomelanocortin-alpha	Mus musculus	126-130
6251378-0	1980	Role of corticosteroid-binding globulin in interaction of corticosterone with uterine and brain progesterone receptors.	Corticosterone	58-72	serpin family A member 6	Homo sapiens	8-39
6250679-6	1980	The increase elicited by ACTH was smaller in LS but, since it was maintained for longer, the plasma corticosterone response was at least 18% larger than that in RIR birds.	Corticosterone	100-114	proopiomelanocortin	Homo sapiens	25-29
6253588-8	1980	This maximum response was about half that found for both aldosterone and corticosterone when stimulated maximally by K+ or serotonin: [des-Asp1,Ile5]- and [des-Asp1,Val5]-angiotensin II (angiotensin III) gave similar response characteristics but had a lower potency in this cell preparation.	Corticosterone	73-87	angiotensinogen	Rattus norvegicus	171-185
7413588-0	1980	Effect of dietary protein and fat levels on fattening of corticosterone-injected broiler chicks.	Corticosterone	57-71	FAT atypical cadherin 1	Homo sapiens	30-33
7413588-4	1980	However, corticosterone-injected birds fed the diet containing the narrower E:P ratio had smaller livers which also contained less fat than chicks fed the diet with a wide E:P ratio.	Corticosterone	9-23	FAT atypical cadherin 1	Homo sapiens	131-134
7230878-1	1980	A combined cell fractionation-radioimmunoassay procedure is described to measure tissue and cell nuclear levels of corticosterone (CORT) in rat brain in intact animals in morning, afternoon, and following ether stress as well as in adrenalectomized animals with and without replacement therapy.	Corticosterone	115-129	cortistatin	Rattus norvegicus	131-135
6250679-12	1980	After intra-abdominal injection of corticosterone, plasma GH concentration was depressed in both strains.	Corticosterone	35-49	growth hormone 1	Homo sapiens	58-60
6250679-13	1980	It is concluded that ACTH-induced depression of plasma GH and growth is mediated by corticosterone.	Corticosterone	84-98	proopiomelanocortin	Homo sapiens	21-25
6250679-13	1980	It is concluded that ACTH-induced depression of plasma GH and growth is mediated by corticosterone.	Corticosterone	84-98	growth hormone 1	Homo sapiens	55-57
7380706-2	1980	Inverse relationships between corticosterone and thyrotropin or growth hormone were noted after exposure for 1 h at 50 mW.cm-2 and above.	Corticosterone	30-44	gonadotropin releasing hormone receptor	Rattus norvegicus	64-78
6772332-0	1980	[Effect of the equilibrium constant of steroid-transcortin binding on the metabolic clearance rate of cortisol and corticosterone in the rabbit].	Corticosterone	115-129	corticosteroid-binding globulin	Oryctolagus cuniculus	47-58
6772332-2	1980	This marked difference in the clearance kinetics of both glucocorticosteroids appears to result from a difference in the affinity of transcortin (CBG) towards both hormones, since the maximal association constant of CBG was twice as high for cortisol as for corticosterone.	Corticosterone	258-272	corticosteroid-binding globulin	Oryctolagus cuniculus	133-144
6772332-2	1980	This marked difference in the clearance kinetics of both glucocorticosteroids appears to result from a difference in the affinity of transcortin (CBG) towards both hormones, since the maximal association constant of CBG was twice as high for cortisol as for corticosterone.	Corticosterone	258-272	corticosteroid-binding globulin	Oryctolagus cuniculus	146-149
6772332-2	1980	This marked difference in the clearance kinetics of both glucocorticosteroids appears to result from a difference in the affinity of transcortin (CBG) towards both hormones, since the maximal association constant of CBG was twice as high for cortisol as for corticosterone.	Corticosterone	258-272	corticosteroid-binding globulin	Oryctolagus cuniculus	216-219
6990145-0	1980	The participation of corticosterone in luteinizing hormone releasing hormone (LH-RH) action on luteinizing hormone (LH) release from anterior pituitary cells in vitro.	Corticosterone	21-35	gonadotropin releasing hormone 1	Homo sapiens	39-76
7402998-8	1980	It is concluded that fattening of chicks induced by injections of corticosterone and prolactin is mainly due to the effect of corticosterone.	Corticosterone	126-140	prolactin	Homo sapiens	85-94
7365003-0	1980	alpha-MSH- and novelty-induced emotional responses in rats: associated changes in plasma corticosterone and brain catecholamines.	Corticosterone	89-103	proopiomelanocortin	Rattus norvegicus	0-9
7365004-3	1980	Free ingestion of tap water following sucrose consumption accelerated the decline from peak level of corticosterone during the period 60-120 min following the onset of sucrose consumption.	Corticosterone	101-115	nuclear RNA export factor 1	Rattus norvegicus	18-21
6990145-0	1980	The participation of corticosterone in luteinizing hormone releasing hormone (LH-RH) action on luteinizing hormone (LH) release from anterior pituitary cells in vitro.	Corticosterone	21-35	gonadotropin releasing hormone 1	Homo sapiens	78-83
232023-2	1979	Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20-68% of peak values 30 h thereafter.	Corticosterone	166-180	proopiomelanocortin	Homo sapiens	21-25
6781402-2	1980	Chlorpromazine induces a modification of plasma corticosterone, gonadotropins and prolactin (increase in corticosterone and prolactin at G1, p less than 0,001 or P less than 0,01; decrease in LH at G2, p less than 0,01; no modification of FSH).	Corticosterone	105-119	prolactin	Rattus norvegicus	82-91
7376973-0	1980	Brain glucocorticoid receptor: correlation of in vivo uptake of corticosterone with behavioral, endocrine, and neuropharmacological events.	Corticosterone	64-78	nuclear receptor subfamily 3 group C member 1	Homo sapiens	6-29
7460794-1	1980	Chronic administration of corticosterone (5 mg/kg) to developing rats induced an increase of tryptophan hydroxylase (TPH) activity in midbrain, but the responsivity of the enzyme to the steroid appeared to be limited only to a brief neonatal period (days 6-12).	Corticosterone	26-40	tryptophan hydroxylase 1	Rattus norvegicus	93-115
7460794-1	1980	Chronic administration of corticosterone (5 mg/kg) to developing rats induced an increase of tryptophan hydroxylase (TPH) activity in midbrain, but the responsivity of the enzyme to the steroid appeared to be limited only to a brief neonatal period (days 6-12).	Corticosterone	26-40	tryptophan hydroxylase 1	Rattus norvegicus	117-120
7420774-5	1980	When female rats were treated with lysine vasopressin for 5 days 10 min before the food presentation, highly elevated levels of plasma corticosterone were found at the time of food presentation.	Corticosterone	135-149	arginine vasopressin	Rattus norvegicus	42-53
7420774-7	1980	The results suggest that vasopressin is involved in the acquisition and consolidation of the conditioned circadian rhythm of plasma corticosterone induced by restricted feeding.	Corticosterone	132-146	arginine vasopressin	Rattus norvegicus	25-36
232023-2	1979	Adrenocorticotropin (ACTH)-induced steroidogenesis, obtained by continuous administration of ACTH for 3 days, produces in man (a) sustained elevations of plasma deoxycorticosterone and cortisol concentrations, (b) transient elevations of plasma aldosterone and 18-hydroxycorticosterone concentrations that return to near-control values, and (c) brisk initial increases in plasma 18-hydroxydeoxycorticosterone and corticosterone concentrations that fall to 20-68% of peak values 30 h thereafter.	Corticosterone	166-180	proopiomelanocortin	Homo sapiens	93-97
24896885-2	1979	It was found that (1) treatment with electric foot-shock and single injections of ACTH (one dose level) lead to comparable increases in subsequent fighting in intact males; (2) preventing changes in testosterone secretion by combined castration and testosterone replacement does not occlude or modify the facilitatory effects of shock or ACTH on subsequent fighting; and (3) preventing changes in both testosterone and corticosterone secretion by combined castration-adrenalectomy and testosterone-corticosterone replacement prevents shock and ACTH induced increases in fighting.	Corticosterone	419-433	pro-opiomelanocortin-alpha	Mus musculus	82-86
24896885-2	1979	It was found that (1) treatment with electric foot-shock and single injections of ACTH (one dose level) lead to comparable increases in subsequent fighting in intact males; (2) preventing changes in testosterone secretion by combined castration and testosterone replacement does not occlude or modify the facilitatory effects of shock or ACTH on subsequent fighting; and (3) preventing changes in both testosterone and corticosterone secretion by combined castration-adrenalectomy and testosterone-corticosterone replacement prevents shock and ACTH induced increases in fighting.	Corticosterone	498-512	pro-opiomelanocortin-alpha	Mus musculus	82-86
226122-10	1979	All of the different forms of ACTH stimulate the synthesis of corticosterone and related steroids; no significant production of cortisol or aldosterone was observed.	Corticosterone	62-76	pro-opiomelanocortin-alpha	Mus musculus	30-34
118311-1	1979	White Leghorn embryos infused with corticosterone precociously reproduced the hatching surges of hepatic UDPglucuronosyltransferase activity to 2-aminophenol, aminopyrine N-demethylase activity and cytochrome P-450 concentration.	Corticosterone	35-49	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	198-214
479350-2	1979	AII 2.4 X 10(-8) M) elicited an 80% increase in 18-OHDOC levels as well as similar increases in aldosterone, 18-hydroxycorticosterone, and corticosterone (P less than 0.01).	Corticosterone	119-133	angiotensinogen	Homo sapiens	0-3
223358-1	1979	The effects of corticosterone and cortisol in concentrations attainable in the adrenal gland were studied on ACTH-induced steroidogenesis in cultured cortical cells of foetal human and rat adrenals.	Corticosterone	15-29	proopiomelanocortin	Homo sapiens	109-113
465866-2	1979	administration of saline, met-enkephalin, or naltrexone raised plasma corticosterone levels in mice.	Corticosterone	70-84	pro-opiomelanocortin-alpha	Mus musculus	26-40
465866-6	1979	met-enkephalin, plasma corticosterone was significantly elevated by ether stress, the effect being blocked by simultaneous injection of met-enkephalin and naltrexone.	Corticosterone	23-37	pro-opiomelanocortin-alpha	Mus musculus	0-14
465866-6	1979	met-enkephalin, plasma corticosterone was significantly elevated by ether stress, the effect being blocked by simultaneous injection of met-enkephalin and naltrexone.	Corticosterone	23-37	pro-opiomelanocortin-alpha	Mus musculus	136-150
219653-0	1979	Effects of prolonged infusions of potassium chloride, adrenocorticotrophin or angiotensin II upon serum aldosterone concentration and the conversion of corticosterone to aldosterone in rats.	Corticosterone	152-166	angiotensinogen	Rattus norvegicus	78-92
223504-4	1979	ACTH in the presence of corticosterone produced a coincident peak in tyrosinase activity and cAMP levels followed by a depression of enzymatic activity.	Corticosterone	24-38	proopiomelanocortin	Homo sapiens	0-4
220036-2	1979	Corticosterone, particularly hydrocortisone, were effective in increasing the ability of mouse mammary cells to bind [125I]PRL.	Corticosterone	0-14	prolactin	Mus musculus	123-126
457953-1	1979	Corticosterone, the principal glucocorticoid in the rat, binds selectively to the CA1 pyramidal neurons of the hippocampus where the hormone has been demonstrated to exert a moderate chronic suppression of spontaneous activity.	Corticosterone	0-14	carbonic anhydrase 1	Rattus norvegicus	82-85
221180-3	1979	Corticosterone at a concentration of 0.5--50 micrograms/ml inhibited ACTH-induced steroidogenesis in a dose-related manner.	Corticosterone	0-14	pro-opiomelanocortin-alpha	Mus musculus	69-73
438709-7	1979	The reduction in the adrenal corticosterone content was accompanied by and may have resulted from, a reduction in the concentration of cytochrome P-450 in the adrenal tissue of foetuses maintained at high altitude.	Corticosterone	29-43	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	135-151
35343-7	1979	These results indicate that the release of ACTH is controlled specifically by HY-CRF and corticosterone, and modified slightly by some other substances such as vasopressin and prostaglandins, and that the effect of most other neurogenic peptides and neurotransmitter substances is negligible or non-physiological at the pituitary level.	Corticosterone	89-103	proopiomelanocortin	Homo sapiens	43-47
217660-1	1978	Hypophysectomized rats bearing three transplanted pituitaries under the kidney capsule responded to synthetic lysine vasopressin or pitressin with a significant elevation of plasma corticosterone, whereas hypophysectomized rats with no grafts did not.	Corticosterone	181-195	arginine vasopressin	Rattus norvegicus	117-128
42252-7	1979	In contrast the cytochrome P-450 catalyzed NADPH-dependent reaction with the same substrate gives corticosterone, O2- represents only an intermediate in the activation of oxygen and is not the "activated oxygen" species.	Corticosterone	98-112	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-32
232360-2	1979	ACTH content of the incubation medium was measured by radioimmunoassay or by the corticosterone production of trypsinisolated adrenocortical cells.	Corticosterone	81-95	proopiomelanocortin	Homo sapiens	0-4
551098-8	1979	The second feedback-inhibition system, responsible for increased numbers of circulating monocytes paralleled by an enhanced delayed hypersensitivity response, was expressed in a decreased corticosterone plasma level, most probably secondary to a diminished release of ACTH from the pituitary gland.	Corticosterone	188-202	pro-opiomelanocortin-alpha	Mus musculus	268-272
220413-3	1979	Adrenalectomy resulted in a rise and corticosterone treatment a fall in the hypothalamic CRH content and the plasma ACTH concentration.3.	Corticosterone	37-51	corticotropin releasing hormone	Rattus norvegicus	89-92
220413-8	1979	The ability of adenohypophyses and hypothalami to synthesize and release in vitro ACTH and CRH respectively in response to trophic stimuli was exaggerated in glands removed from adrenalectomized rats and reduced in those removed from corticosterone-treated rats.6.	Corticosterone	234-248	corticotropin releasing hormone	Rattus norvegicus	91-94
220413-9	1979	Addition of corticosterone to the pre-incubation medium reduced the capacities of adenohypophyses and hypothalami removed from untreated rats to synthesize and release ACTH and CRH respectively.	Corticosterone	12-26	corticotropin releasing hormone	Rattus norvegicus	177-180
731146-2	1978	The binding characteristics were similar to those exhibited by transcortin: radioactive corticosterone was bound to a greater extent than radioactive dexamethasone and labelled corticosterone, but not labelled dexamethasone, was displaced by unlabelled corticosterone, deoxycorticosterone and progesterone.	Corticosterone	88-102	serpin family A member 6	Rattus norvegicus	63-74
731146-2	1978	The binding characteristics were similar to those exhibited by transcortin: radioactive corticosterone was bound to a greater extent than radioactive dexamethasone and labelled corticosterone, but not labelled dexamethasone, was displaced by unlabelled corticosterone, deoxycorticosterone and progesterone.	Corticosterone	177-191	serpin family A member 6	Rattus norvegicus	63-74
731146-2	1978	The binding characteristics were similar to those exhibited by transcortin: radioactive corticosterone was bound to a greater extent than radioactive dexamethasone and labelled corticosterone, but not labelled dexamethasone, was displaced by unlabelled corticosterone, deoxycorticosterone and progesterone.	Corticosterone	177-191	serpin family A member 6	Rattus norvegicus	63-74
760829-3	1979	Rat serum or insufficiently perfused tissue contained a corticosterone-binding component with pI of 5.2--5.5 representing corticosteroid-binding globulin.	Corticosterone	56-70	serpin family A member 6	Rattus norvegicus	122-153
218133-2	1979	It was shown that corticosterone (CORT) inhibited ACTH output provoked by either corticotropin-releasing factor (CRF) extracts or dbcAMP, in a manner which was both dose- and time-dependent.	Corticosterone	18-32	cortistatin	Homo sapiens	34-38
218133-2	1979	It was shown that corticosterone (CORT) inhibited ACTH output provoked by either corticotropin-releasing factor (CRF) extracts or dbcAMP, in a manner which was both dose- and time-dependent.	Corticosterone	18-32	proopiomelanocortin	Homo sapiens	50-54
218133-2	1979	It was shown that corticosterone (CORT) inhibited ACTH output provoked by either corticotropin-releasing factor (CRF) extracts or dbcAMP, in a manner which was both dose- and time-dependent.	Corticosterone	18-32	corticotropin releasing hormone	Homo sapiens	81-111
215134-6	1978	The angiotensin II antagonist [Sar(1),Ala(8)]angiotensin II inhibited angiotensin II-stimulated corticosterone and aldosterone production in these cells.	Corticosterone	96-110	angiotensinogen	Rattus norvegicus	4-18
215134-6	1978	The angiotensin II antagonist [Sar(1),Ala(8)]angiotensin II inhibited angiotensin II-stimulated corticosterone and aldosterone production in these cells.	Corticosterone	96-110	angiotensinogen	Rattus norvegicus	45-59
215134-6	1978	The angiotensin II antagonist [Sar(1),Ala(8)]angiotensin II inhibited angiotensin II-stimulated corticosterone and aldosterone production in these cells.	Corticosterone	96-110	angiotensinogen	Rattus norvegicus	45-59
215134-9	1978	Increasing concentrations of [Sar(1),Ala(8)]angiotensin II alone decreased corticosterone and aldosterone outputs significantly (P&lt;0.05) at concentrations of 20nm and 2nm of antagonist respectively.	Corticosterone	75-89	angiotensinogen	Rattus norvegicus	44-58
307406-4	1978	By utilizing artificial hydroxylating agents such as cumene hydroperoxide, H2O2, and sodium periodate, the hydroxylation reaction of deoxycorticosterone to corticosterone in the absence of NADPH was observed to a comparable extent with the reaction in the presence of adrenodoxin reductase, adrenodoxin and NADPH.	Corticosterone	138-152	ferredoxin reductase	Bos taurus	268-289
210838-14	1978	Decreases in plasma corticosterone correlated directly with decreases in cholesterol combination with cytochrome P-450scc (r=0.94).	Corticosterone	20-34	cytochrome P450, family 11, subfamily a, polypeptide 1	Rattus norvegicus	113-121
710373-4	1978	The eisodic secretion of corticosterone seemed to inhibit the subsequent growth hormone burst but not vice versa.	Corticosterone	25-39	gonadotropin releasing hormone receptor	Rattus norvegicus	73-87
213260-2	1978	In adrenalectomized rats treated with corticosterone, lipase activity was as low as in untreated adrenalectomized rats, although adrenaline-induced lipolysis was not reduced.	Corticosterone	38-52	lipase G, endothelial type	Rattus norvegicus	54-60
710373-5	1978	The interrelation between integrated concentrations of growth hormone and corticosterone showed a negative correlation although the coefficient was not statistically significant.	Corticosterone	74-88	gonadotropin releasing hormone receptor	Rattus norvegicus	55-69
210723-7	1978	ACTH plus corticosterone stimulated tyrosinase activity coincident with the early cyclic nucleotide peak followed by a drop in tyrosinase activity which was subsequently elevated.	Corticosterone	10-24	tyrosinase	Homo sapiens	36-46
19605227-0	1978	Specific [(3)H]corticosterone uptake in the hippocampus and septum varies with social settings in mice: Hormone-receptor autoregulation may be involved.	Corticosterone	15-29	nuclear receptor subfamily 4, group A, member 1	Mus musculus	104-120
212744-5	1978	It is devoid of corticosteroidogenic activity but is able to inhibit ACTH-stimulated corticosterone production in isolated rat adrenal cells.	Corticosterone	85-99	proopiomelanocortin	Homo sapiens	69-73
213826-0	1978	[Relationship between plasma levels of cortisol and corticosterone in subjects with different ACTH activity (author"s transl)].	Corticosterone	52-66	proopiomelanocortin	Homo sapiens	94-98
210723-7	1978	ACTH plus corticosterone stimulated tyrosinase activity coincident with the early cyclic nucleotide peak followed by a drop in tyrosinase activity which was subsequently elevated.	Corticosterone	10-24	tyrosinase	Homo sapiens	127-137
210723-8	1978	The results indicate that neither cAMP nor cGMP are the sole modulators of tyrosinase activity and suggest the interaction of ACTH, corticosterone and cyclic nucleotides in the regulation of melanoma tyrosinase activity.	Corticosterone	132-146	tyrosinase	Homo sapiens	200-210
206084-2	1978	It was shown that corticosterone and thyroxine exerted antagonistic effects on both the transcortin-like component and true receptor present in the hypophysis: thyroid hormones, in contrast to glucocorticoids which exhibited opposite influence, increased maximum binding without affecting significantly the apparent association constant.	Corticosterone	18-32	serpin family A member 6	Homo sapiens	88-99
210471-0	1978	ACTH effects on response suppression and plasma corticosterone in the mouse.	Corticosterone	48-62	pro-opiomelanocortin-alpha	Mus musculus	0-4
634292-1	1978	Evaluating plasma levels of cortisol and corticosterone after ACTH-stimulation, and the urinary metabolites tetrahydrocortisone and tetrahydrocortisol in asthmatic children it could be demonstrated, that in most cases there was no suppression of adrenal function following treatment over 6 to 18 months with a daily dose of 200 to 300 microgram beclomethasone dipropionate.	Corticosterone	41-55	proopiomelanocortin	Homo sapiens	62-66
631183-2	1978	Plasma corticosterone levels were used as an index of adrenocorticotropic hormone (ACTH) release.	Corticosterone	7-21	pro-opiomelanocortin-alpha	Mus musculus	54-81
212766-4	1978	The only regionally specific effect of the hormones was an increased 2DG uptake in olfactory bulb by saline, ACTH/MSH4-10 And corticosterone relative to uninjected animals.	Corticosterone	126-140	pro-opiomelanocortin-alpha	Mus musculus	109-113
215930-1	1978	After the combined treatment with dexamethasone, morphine and pentobarbitone, the electrical stimulation in the rat tuber cinereum induces a rise in plasma corticosterone (CS) level, probably by direct stimulation of the corticoliberin-producing neural elements and the consecutive ACTH release.	Corticosterone	156-170	corticotropin releasing hormone	Rattus norvegicus	221-235
634981-0	1978	The influence of adrenalectomy and of corticosterone administration on the ether-induced increase in plasma prolactin in ovariectomized estrogen-treated rats.	Corticosterone	38-52	prolactin	Rattus norvegicus	108-117
208885-5	1978	Corticosterone depressed cAMP levels while stimulating tyrosinase activity.	Corticosterone	0-14	tyrosinase	Homo sapiens	55-65
208885-7	1978	ACTH plus corticosterone stimulated tyrosine activity coincident with the early cAMP peak followed by a drop in tyrosinase activity which was subsequently elevated.	Corticosterone	10-24	tyrosinase	Homo sapiens	112-122
208885-9	1978	The results indicate that cAMP is not the sole modulator of tyrosinase activity and suggest the interaction of ACTH, corticosterone and cAMP in the regulation of melanoma tyrosinase activity.	Corticosterone	117-131	tyrosinase	Homo sapiens	171-181
217583-3	1978	Cortisol and corticosterone are almost as potent as dexamethasone in inhibiting ACTH release, whereas 17 beta-estradiol and testosterone have no effect.	Corticosterone	13-27	pro-opiomelanocortin-alpha	Mus musculus	80-84
215930-1	1978	After the combined treatment with dexamethasone, morphine and pentobarbitone, the electrical stimulation in the rat tuber cinereum induces a rise in plasma corticosterone (CS) level, probably by direct stimulation of the corticoliberin-producing neural elements and the consecutive ACTH release.	Corticosterone	172-174	corticotropin releasing hormone	Rattus norvegicus	221-235
304104-10	1977	Noradrenaline, GABA and corticosterone reduced the acetylcholine- and 5-HT-induced increases in the release of CRH from the hypothalamus.	Corticosterone	24-38	corticotropin releasing hormone	Rattus norvegicus	111-114
304104-11	1977	The rises in CRH content induced by acetylcholine and 5-HT were also reduced by noradrenaline and GABA but increased by corticosterone.	Corticosterone	120-134	corticotropin releasing hormone	Rattus norvegicus	13-16
201453-1	1977	Corticosterone formation was determined in the reconstructed rat adrenal system which consisted of the mitochondria and post-mitochondrial supernatant fraction (PM-fraction) supported by l-malate, and effect of ACTH and cycloheximide in vivo and cycloheximide, Ca++ and sterol carrier protein (SCP) in vitro were examined.	Corticosterone	0-14	fatty acid binding protein 1	Rattus norvegicus	294-297
201938-2	1977	A series of short ACTH analogues (ACTH 11-24, ACTH 4-10) had slight influences on circulating plasma corticosterone values and on fighting behavior.	Corticosterone	101-115	pro-opiomelanocortin-alpha	Mus musculus	18-22
201938-2	1977	A series of short ACTH analogues (ACTH 11-24, ACTH 4-10) had slight influences on circulating plasma corticosterone values and on fighting behavior.	Corticosterone	101-115	pro-opiomelanocortin-alpha	Mus musculus	34-38
201938-2	1977	A series of short ACTH analogues (ACTH 11-24, ACTH 4-10) had slight influences on circulating plasma corticosterone values and on fighting behavior.	Corticosterone	101-115	pro-opiomelanocortin-alpha	Mus musculus	34-38
201453-5	1977	The SCP-bound cholesterol was utilized for corticosterone formation more efficiently than the free cholesterol when added to the incubation mixture, and this might be due to, at least in part, higher rate of binding to the mitochondrial inner membrane of the SCP-bound cholesterol.	Corticosterone	43-57	fatty acid binding protein 1	Rattus norvegicus	4-7
201453-5	1977	The SCP-bound cholesterol was utilized for corticosterone formation more efficiently than the free cholesterol when added to the incubation mixture, and this might be due to, at least in part, higher rate of binding to the mitochondrial inner membrane of the SCP-bound cholesterol.	Corticosterone	43-57	fatty acid binding protein 1	Rattus norvegicus	259-262
198428-0	1977	The variations of plasma corticosterone/cortisol ratios following ACTH stimulation or dexamethasone administration in normal men.	Corticosterone	25-39	proopiomelanocortin	Homo sapiens	66-70
21065-4	1977	In Adx mice receiving daily injections of corticosterone (0.5 mg/mouse), the ethanol-induced increase of brain TPH activity and the occurrence of withdrawal audiogenic seizures were both restored.	Corticosterone	42-56	tryptophan hydroxylase 1	Mus musculus	111-114
21834-8	1977	The serum corticosterone level was increased and shortly after the elevation of corticosterone, hepatic TAT levels also increased.	Corticosterone	10-24	tyrosine aminotransferase	Rattus norvegicus	104-107
591850-4	1977	These results suggest that corticosterone may be responsible for the observed changes in transcortin concentration.	Corticosterone	27-41	serpin family A member 6	Rattus norvegicus	89-100
193682-5	1977	However, when given in combination with ACTH, growth hormone synergistically enhanced the effects of ACTH on cholesterol sidechain cleavage activity and corticosterone secretion.	Corticosterone	153-167	gonadotropin releasing hormone receptor	Rattus norvegicus	46-60
193682-7	1977	The results indicate that growth hormone interacts with ACTH to promote corticosterone secretion by increasing the association of cholesterol with adrenal mitochondrial cytochrome P-450, thereby increasing the activity of cholesterol sidechain cleavage, the rate-limiting step in steroidogenesis.	Corticosterone	72-86	gonadotropin releasing hormone receptor	Rattus norvegicus	26-40
193682-7	1977	The results indicate that growth hormone interacts with ACTH to promote corticosterone secretion by increasing the association of cholesterol with adrenal mitochondrial cytochrome P-450, thereby increasing the activity of cholesterol sidechain cleavage, the rate-limiting step in steroidogenesis.	Corticosterone	72-86	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	169-185
198428-2	1977	Plasma corticosterone increased 4.83 times as much as basal value at 60 min after an im injection of 0.25 mg synthetic beta1-24 ACTH (Cortrosyn) in normal subjects, whereas plasma cortisol increased 2.12 times as much at 60 min.	Corticosterone	7-21	proopiomelanocortin	Homo sapiens	128-132
198428-3	1977	And basal corticosterone/cortisol ratio of 0.053 +/- 0.017 increased to 0.116 +/- 0.022 (P less than 0.001) after ACTH.	Corticosterone	10-24	proopiomelanocortin	Homo sapiens	114-118
14006-2	1977	The macromolecules binding corticosterone and its metabolites were characterized as (a) a steroid conjugate-binding (Stokes radius 2.5 nm and sedimentation coefficient 4.1 S in high ionic strength; pI 8.7, (b) transcortin and (c) a glucocorticoid "receptor".	Corticosterone	27-41	serpin family A member 6	Rattus norvegicus	210-221
192977-0	1977	The effects of pineal indoles and a crude aqueous pineal extract on ACTH mediated corticosterone release by isolated adrenal cells.	Corticosterone	82-96	proopiomelanocortin	Homo sapiens	68-72
14006-3	1977	Competition experiments indicate that corticosterone and dexamethasone bind to the same site of the glucocorticoid receptor molecule.	Corticosterone	38-52	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	100-123
186299-1	1976	Stress or administration of ACTH to pregnant mice gave rise to much higher plasma corticosterone levels in the second half of pregnancy than in the first half, suggesting that there may be increased adrenal sensitivity to ACTH or decreased metabolism of corticosterone during the second half of pregnancy.	Corticosterone	82-96	pro-opiomelanocortin-alpha	Mus musculus	28-32
844145-3	1977	Angiotensin II in a subpressor dose produced a significant decrease of the MCR of aldosterone (by 23%), cortisol (by 16%), DOC (by 26%), corticosterone (by 14%) and progesterone (by 33%).	Corticosterone	137-151	angiotensinogen	Homo sapiens	0-14
844145-8	1977	We conclude that angiotensin II, by its vasoconstrictive action on the splanchnic vascular bed, decreases the MCR of aldosterone, cortisol, DOC, corticosterone, and progesterone.	Corticosterone	145-159	angiotensinogen	Homo sapiens	17-31
832143-0	1977	Effect of corticosterone on the synthesis of [3H]catecholamines in the brains of CD-1 mice.	Corticosterone	10-24	CD1 antigen complex	Mus musculus	81-85
189465-1	1976	A radioimmunoassay for corticosterone was developed using an antibody to corticosterone-21-hemisuccinate:bovine serum albumin.	Corticosterone	23-37	albumin	Homo sapiens	112-125
189465-3	1976	Tests of adrenal function showed that stimulation of the adrenal with exogenous ACTH and with dexamethasone caused an increase and decrease, respectively, in plasma concentrations of corticosterone.	Corticosterone	183-197	proopiomelanocortin	Homo sapiens	80-84
101322-1	1977	Many of the factors altering corticosterone in the rat have similar effects on prolactin.	Corticosterone	29-43	prolactin	Rattus norvegicus	79-88
101322-2	1977	Resting prolactin, like corticosterone, is higher in animals housed singly than in those multiply housed.	Corticosterone	24-38	prolactin	Rattus norvegicus	8-17
101322-5	1977	Like corticosterone, the pattern of prolactin stress responses varies according to time of day.	Corticosterone	5-19	prolactin	Rattus norvegicus	36-45
188965-7	1977	infusion of synthetic ACTH increased the plasma concentrations of both steroids to maximal values of 0-42 +/- 0-23 mug cortisol/100 ml and 1-06 +/- 0-56 mug corticosterone/100 ml at infusion rates of 1 i.u.	Corticosterone	157-171	proopiomelanocortin	Homo sapiens	22-26
188965-13	1977	The metabolic clearance rate of cortisol was greater than that of corticosterone and both were depressed by ACTH.	Corticosterone	66-80	proopiomelanocortin	Homo sapiens	108-112
1022521-2	1976	Antiserum against corticosterone was produced in rabbits immunized with corticosterone-21-hemisuccinate conjugated to bovine serum albumin.	Corticosterone	18-32	albumin	Oryctolagus cuniculus	125-138
994021-4	1976	Corticosterone in a dose of 100 mg/kg increased DBH activity but decreased hypothalamic norepinephrine and copamine content.	Corticosterone	0-14	dopamine beta-hydroxylase	Rattus norvegicus	48-51
186299-1	1976	Stress or administration of ACTH to pregnant mice gave rise to much higher plasma corticosterone levels in the second half of pregnancy than in the first half, suggesting that there may be increased adrenal sensitivity to ACTH or decreased metabolism of corticosterone during the second half of pregnancy.	Corticosterone	82-96	pro-opiomelanocortin-alpha	Mus musculus	222-226
186299-1	1976	Stress or administration of ACTH to pregnant mice gave rise to much higher plasma corticosterone levels in the second half of pregnancy than in the first half, suggesting that there may be increased adrenal sensitivity to ACTH or decreased metabolism of corticosterone during the second half of pregnancy.	Corticosterone	254-268	pro-opiomelanocortin-alpha	Mus musculus	28-32
190605-1	1976	It was shown in vitro that ACTH influenced the progesterone transformation increasing corticosterone production only in those fetuses whose adrenal glands, in the absence of ACTH, transformed progesterone chiefly into hydrocortisone (8--12-week fetuses).	Corticosterone	86-100	proopiomelanocortin	Homo sapiens	27-31
1010117-4	1976	Hypophysectomy decreased plasma free fatty acids, aminoacids and insulin levels; growth hormone and growth hormone + corticosterone treatments in hypophysectomized animals induced opposite changes, while corticosterone alone only increased the concentrations of plasma aminoacids and insulin.	Corticosterone	117-131	insulin	Anas platyrhynchos	284-291
967301-8	1976	A large dose of corticosterone (B) caused an increase in hypothalamic DBH.	Corticosterone	16-30	dopamine beta-hydroxylase	Rattus norvegicus	70-73
942517-5	1976	Corticosterone production was enhanced by prolactin, reduced by perphenazine and unaffected by reserpine.	Corticosterone	0-14	prolactin	Rattus norvegicus	42-51
182222-1	1976	Using a gel filtration on Sephadex G-150 in low ionic strength, it was possible to separate a corticosterone-binding protein in rat liver cytosol from corticosteroid-binding globulin after incubation of cytosol with [3H]corticosterone.	Corticosterone	94-108	serpin family A member 6	Rattus norvegicus	151-182
182222-1	1976	Using a gel filtration on Sephadex G-150 in low ionic strength, it was possible to separate a corticosterone-binding protein in rat liver cytosol from corticosteroid-binding globulin after incubation of cytosol with [3H]corticosterone.	Corticosterone	220-234	serpin family A member 6	Rattus norvegicus	151-182
945155-6	1976	The possibility was raised that prolactin exhibits a diurnal variation in sensitivity to stress which varies as a function of circulating levels of corticosterone.	Corticosterone	148-162	prolactin	Rattus norvegicus	32-41
1248073-6	1976	A significant (P less than 0.01) mutual positive correlation was found between the secretion rates of 18-OH DOC, DOC and corticosterone in patients with low plasma renin activity.	Corticosterone	121-135	renin	Homo sapiens	164-169
935029-7	1976	The prolactin injections began 2 days after the first corticosterone injection.	Corticosterone	54-68	prolactin	Gallus gallus	4-13
174733-4	1976	(2) Gel permeation chrmatography with BioRad A-5M reveals the presence of a [3H] corticosterone-macromolecular complex with an elution volume comparable to transcortin as well as a very large hormone-binding complex eluting in the void volume of the column...	Corticosterone	81-95	serpin family A member 6	Rattus norvegicus	156-167
181223-7	1976	The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production.	Corticosterone	84-98	proopiomelanocortin	Homo sapiens	21-25
181223-7	1976	The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production.	Corticosterone	84-98	proopiomelanocortin	Homo sapiens	180-184
181223-7	1976	The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production.	Corticosterone	251-265	proopiomelanocortin	Homo sapiens	21-25
181223-7	1976	The hormonal form of ACTH appears to be an important factor regulating the cortisol/corticosterone ratio in mammalian adrenal corticoid secretion because administration of porcine ACTH to rabbits alters the adrenal secretory pattern so as to decrease corticosterone production and increase cortisol production.	Corticosterone	251-265	proopiomelanocortin	Homo sapiens	180-184
181934-5	1976	It was also found that administration of TRH produced a rise in serum corticosterone concentrations.	Corticosterone	70-84	thyrotropin releasing hormone	Rattus norvegicus	41-44
182121-5	1976	Radioactivity eluted in the 0.02 and 0.06M-phosphate regions on DEAE-cellulose DE-52 appears to be due to [3H]aldosterone binding to glucocorticoid-specific "GR" receptors and to transcortin respectively, since labelling was greater with corticosterone even at 10 nM than with the mineralocorticoid at 100nM and since [14C]corticosterone bound to blood serum transcortin was always co-chromatographed in the 0.06M-phosphate region.	Corticosterone	238-252	serpin family A member 6	Rattus norvegicus	179-190
182121-5	1976	Radioactivity eluted in the 0.02 and 0.06M-phosphate regions on DEAE-cellulose DE-52 appears to be due to [3H]aldosterone binding to glucocorticoid-specific "GR" receptors and to transcortin respectively, since labelling was greater with corticosterone even at 10 nM than with the mineralocorticoid at 100nM and since [14C]corticosterone bound to blood serum transcortin was always co-chromatographed in the 0.06M-phosphate region.	Corticosterone	323-337	serpin family A member 6	Rattus norvegicus	179-190
1250881-4	1976	Corticosterone and progesterone prevented the G6PD changes induced by adrenalectomy and moderated the rise in 20alpha-OHSD.	Corticosterone	0-14	glucose-6-phosphate dehydrogenase	Rattus norvegicus	46-50
190553-6	1976	It is concluded that: (1) the greater ether-induced rise in plasma ACTH in the a.m. than in the p.m. is probably due to the lower plasma (and probably tissue) corticosterone concentration at that time; (2) the plasma ACTH concentration for inducing maximal adrenal activation is relatively low; and (3) the higher basal levels of plasma corticosterone in the p.m. than in the a.m. are due to a slight increase in basal ACTH secretion in the p.m.	Corticosterone	159-173	proopiomelanocortin	Homo sapiens	67-71
190553-6	1976	It is concluded that: (1) the greater ether-induced rise in plasma ACTH in the a.m. than in the p.m. is probably due to the lower plasma (and probably tissue) corticosterone concentration at that time; (2) the plasma ACTH concentration for inducing maximal adrenal activation is relatively low; and (3) the higher basal levels of plasma corticosterone in the p.m. than in the a.m. are due to a slight increase in basal ACTH secretion in the p.m.	Corticosterone	337-351	proopiomelanocortin	Homo sapiens	67-71
1192557-11	1975	Similar conditions seemed to exist in rabbits actively immunized against angiotensin II; these animals exhibited high concentrations of total immunoreactive angiotensin II (up to 200,000 pg/ml) and a small increase in plasma aldosterone and corticosterone concentrations.	Corticosterone	241-255	angiotensinogen	Rattus norvegicus	73-87
1203756-1	1975	When Sephadex G-25 columns are used to separate transcortin-bound corticosterone from free corticosterone, there is a non-linear increase of total binding with increasing plasma volume filtered.	Corticosterone	66-80	serpin family A member 6	Homo sapiens	48-59
1233956-4	1975	A close correlation was found to exist between the concentration of total corticosterone in the blood plasma and CBG.	Corticosterone	74-88	serpin family A member 6	Rattus norvegicus	113-116
1237331-0	1975	Reduction in the cholinesterase activity of the rat anococcygeus muscle produced by corticosterone.	Corticosterone	84-98	butyrylcholinesterase	Rattus norvegicus	17-31
1237331-1	1975	1 Administration of corticosterone caused a 47% reduction in the cholinesterase (ChE) activity of homogenates of the rat anococcygeus muscle.	Corticosterone	20-34	butyrylcholinesterase	Rattus norvegicus	65-79
1237331-1	1975	1 Administration of corticosterone caused a 47% reduction in the cholinesterase (ChE) activity of homogenates of the rat anococcygeus muscle.	Corticosterone	20-34	butyrylcholinesterase	Rattus norvegicus	81-84
1237331-6	1975	6 The reduction in ChE activity produced by corticosterone, morphine withdrawal, or a single dose of reserpine might explain the leftward shift of the dose-% response curve to acetylcholine produced by these procedures in the isolated anococcygeus muscle of the rat.	Corticosterone	44-58	butyrylcholinesterase	Rattus norvegicus	19-22
169120-0	1975	Corticosterone-induced changes in hypothalamic corticotropin-releasing factor (CRF) content after stress.	Corticosterone	0-14	corticotropin releasing hormone	Rattus norvegicus	47-77
1175088-6	1975	Corticosterone and prolactin levels were highly correlated and each was negatively correlated with growth hormone levels.	Corticosterone	0-14	gonadotropin releasing hormone receptor	Rattus norvegicus	99-113
1188062-0	1975	[Binding of corticosterone to transcortin of the serum of rats at distant period following irradiation].	Corticosterone	12-26	serpin family A member 6	Rattus norvegicus	30-41
1233956-5	1975	Increases in the total concentration of corticosterone in blood plasma are, in 84% of all cases, brought about by increases in CBG concentrations.	Corticosterone	40-54	serpin family A member 6	Rattus norvegicus	127-130
168295-6	1975	Prolonged treatment of laying hens with protamine zinc insulin led to aphagia and cessation of egg-laying; increased concentrations of corticosterone were observed 2 days after the administration of insulin ceased, coinciding with the return to normal plasma levels of glucose.	Corticosterone	135-149	insulin	Gallus gallus	199-206
167924-4	1975	An increase of the metabolic clearance rate of corticosterone, observed as a function of the infusion rate, was ascribed to saturation by the steroid of the plasma transcortin binding sites.	Corticosterone	47-61	serpin family A member 6	Rattus norvegicus	164-175
168295-8	1975	It appears likely that the adrenal medulla is a target for corticosterone which probably regulates the tissue levels of phenylethanolamine-N-methyltransferase, one of the enzymes necessary for the biosynthesis of adrenaline.	Corticosterone	59-73	phenylethanolamine N-methyltransferase	Gallus gallus	120-158
164467-5	1975	Other glucocorticoids appear to stimulate murine mammary tumor virus production by a mechanism similar to that of dexamethasone; for example, corticosterone competes with dexamethasone for binding to the glucocorticoid receptor and blocks the uptake of dexamethasone into cells.	Corticosterone	142-156	nuclear receptor subfamily 3, group C, member 1	Mus musculus	204-227
4423900-0	1974	[Hydrocortisone and corticosterone levels in the plasma and their binding with transcortin in patients with brain tumors].	Corticosterone	20-34	serpin family A member 6	Homo sapiens	79-90
1173303-1	1975	The effect of acute administration of human growth hormone (HGH) and of alpha-melanocyte stimulating hormone (alpha-MSH) on plasma aldosterone, cortisol, corticosterone and growth hormone has been studied in normal man and in patients with panhypopituitarism.	Corticosterone	154-168	proopiomelanocortin	Homo sapiens	72-108
1173303-1	1975	The effect of acute administration of human growth hormone (HGH) and of alpha-melanocyte stimulating hormone (alpha-MSH) on plasma aldosterone, cortisol, corticosterone and growth hormone has been studied in normal man and in patients with panhypopituitarism.	Corticosterone	154-168	proopiomelanocortin	Homo sapiens	110-119
1169697-2	1975	Peak GH values (at miday) appeared to be inversely correlated with the diurnal peak of plasma corticosterone(CS) which occurred after the onset of darkness.	Corticosterone	94-108	gonadotropin releasing hormone receptor	Rattus norvegicus	5-7
1149255-3	1975	The ability of corticosterone, cortisone, 11-deoxycortisol and prednisolone to displace [1,2-3-H] cortisol from corticosteroid-binding globulin (CBG) was measured: (1) by assessing the amounts (ng/tube) which produce a displacement equal to 10 ng/tube of cortisol, and (2) by calculating the integrated areas of displacement defined by the binding curves and by expressing them as a percentage of the cortisol curve area.	Corticosterone	15-29	serpin family A member 6	Homo sapiens	112-143
1168957-2	1975	The observed enthalpies of binding of progesterone, testosterone, dihydrotestosterone, corticosterone and estriol to BSA were found to be -13.24 plus or minus 0.11 -10.31 plus or minus 0.02, -2.37 plus or minus 0.46, -17.64 plus or minus 0.32 and -17.14 plus or minus 0.36 kcal/mol of hormone, respectively.	Corticosterone	87-101	albumin	Homo sapiens	117-120
4374199-7	1974	However, at certain doses of 5-hydroxytryptamine, K(+) and angiotensin II the significant increases in corticosterone output were not accompanied by measurable increases in cyclic AMP accumulation.	Corticosterone	103-117	angiotensinogen	Rattus norvegicus	59-73
4364642-0	1974	Secretion of ACTH by isolated anterior pituitary cells: kinetics of stimulation of corticotropin-releasing factor and of inhibition by corticosterone.	Corticosterone	135-149	proopiomelanocortin	Homo sapiens	13-17
4547308-13	1974	The hyper-secretion of CRH observed in hypothalami taken from adrenalectomized rats was abolished by pre-treatment with 5 mg/100 g s.c. of corticosterone 24 hr before removal of the tissue.	Corticosterone	139-153	corticotropin releasing hormone	Rattus norvegicus	23-26
4547308-14	1974	It is therefore proposed that the delayed negative feed-back action of corticosterone at the hypothalamic level is by the suppression of CRH synthesis and that the effect of secretion is secondary to the effect on synthesis.4.	Corticosterone	71-85	corticotropin releasing hormone	Rattus norvegicus	137-140
4363642-0	1974	Corticosterone suppression of ACTH secretion: actinomycin D sensitive and insensitive components of the response.	Corticosterone	0-14	proopiomelanocortin	Homo sapiens	30-34
4355827-0	1973	Influence of plasma on ACTH stimulated corticosterone production of isolated adrenal cells.	Corticosterone	39-53	proopiomelanocortin	Homo sapiens	23-27
4365628-0	1974	Proceedings: Effect of angiotensin II on cyclic AMP and corticosterone output by purified zona glomerulosa and zona fasciculata cells of the rat adrenal cortex.	Corticosterone	56-70	angiotensinogen	Rattus norvegicus	23-37
4354389-0	1973	The role of transcortin in the distribution of corticosterone in the rat.	Corticosterone	47-61	serpin family A member 6	Rattus norvegicus	12-23
4401603-0	1972	The availability of NADPH for corticosterone reduction in six strains of mice.	Corticosterone	30-44	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	20-25
4357103-0	1973	[On the existence of a fast-acting negative feedback control of ACTH-corticosterone secretion (author"s transl)].	Corticosterone	69-83	proopiomelanocortin	Homo sapiens	64-68
4316573-0	1970	Suppression of ACTH release from adenophypophysis by corticosterone: an in vitro study.	Corticosterone	53-67	proopiomelanocortin	Homo sapiens	15-19
4348818-0	1972	Studies of the potency of polypeptides with ACTH action by a new method based on continuous measurement of plasma corticosterone.	Corticosterone	114-128	proopiomelanocortin	Homo sapiens	44-48
5111566-4	1971	Gonadal growth was also stimulated in photosensitive white-throated sparrows (Zonotrichia albicollis) kept in continuous light by prolactin injected 12 hours after administration of corticosterone.	Corticosterone	182-196	prolactin	Zonotrichia albicollis	130-139
5111566-5	1971	Daily injections of prolactin 8 hours after injection of corticosterone inhibited gonadal growth.	Corticosterone	57-71	prolactin	Zonotrichia albicollis	20-29
5111566-6	1971	The seasonal cycle of reproductive photorefractoriness and photosensitivity is controlled by a changing relation between the daily rhythms of plasma concentrations of corticosterone and prolactin.	Corticosterone	167-181	prolactin	Zonotrichia albicollis	186-195
4331036-0	1971	Evidence for another factor in the regulation of corticosterone biosynthesis by ACTH.	Corticosterone	49-63	proopiomelanocortin	Homo sapiens	80-84
4326999-0	1971	Evidence in favour of a fast feed-back control of ACTH secretion by corticosterone.	Corticosterone	68-82	proopiomelanocortin	Homo sapiens	50-54
5524676-0	1970	Influence of transcortin on degradation and tissue uptake of corticosterone in the infant rat.	Corticosterone	61-75	serpin family A member 6	Homo sapiens	13-24
4391050-3	1969	Direct challenge of the liver with injections of corticosterone or insulin elicited the induction of TAT on an identical time course in young and senescent mice.	Corticosterone	49-63	tyrosine aminotransferase	Mus musculus	101-104
4310487-0	1969	In vitro release of ACTH: effects of potassium, calcium and corticosterone.	Corticosterone	60-74	proopiomelanocortin	Homo sapiens	20-24
4335082-0	1971	Effects of theophylline on corticosterone secretory and adrenal growth response to ACTH in vivo.	Corticosterone	27-41	proopiomelanocortin	Homo sapiens	83-87
4305503-0	1969	Sensitivity of the adrenal corticosterone response to ACTH as a function of time after hypophysectomy.	Corticosterone	27-41	proopiomelanocortin	Homo sapiens	54-58
4298184-0	1968	Acute effects of angiotensin-II-amide on aldosterone and corticosterone secretion by morphine-pentobarbital treated rats.	Corticosterone	57-71	angiotensinogen	Rattus norvegicus	17-31
4303907-0	1969	Influence of cycling, pregnancy, labor, and suckling on corticosterone-ACTH levels.	Corticosterone	56-70	proopiomelanocortin	Homo sapiens	71-75
5665206-0	1968	[Transcortin-corticosterone relationship and control of pituitary-adrenal activity in the rat.	Corticosterone	13-27	serpin family A member 6	Rattus norvegicus	1-12
4294247-2	1966	Secretory rate of corticosterone and cortisol during stimulation of the adrenal cortex with ACTH].	Corticosterone	18-32	proopiomelanocortin	Homo sapiens	92-96
4286686-2	1966	The role of ACTH on the regulation of corticosterone secretion].	Corticosterone	38-52	proopiomelanocortin	Homo sapiens	12-16
14167563-0	1964	THE EFFECT OF LETHAL ALCOHOL DOSE ON THE CORTICOSTERONE CONTENT OF BLOOD AND ON THE ALCOHOLDEHYDROGENASE ACTIVITY OF THE LIVER IN ADRENALECTOMIZED RATS.	Corticosterone	41-55	aldo-keto reductase family 1 member A1	Rattus norvegicus	84-104
4294644-0	1968	Pharmacologic effects of angiotensin-II-amide on aldosterone and corticosterone secretion by the intact anesthetized rat.	Corticosterone	65-79	angiotensinogen	Rattus norvegicus	25-39
5328767-2	1966	The corticosteroids cortisol, cortisone and corticosterone were tested for their ability to affect the hydrolysis of serum albumin, insulin and oxyhaemoglobin incubated with trypsin, chymotrypsin, papain and pepsin.	Corticosterone	44-58	insulin	Homo sapiens	132-139
14162446-0	1964	THE EFFECT OF LETHAL ALCOHOL DOSAGE ON CORTICOSTERONE CONTENT OF THE BLOOD PLASMA OF INTACT RATS AND ON ALCOHOLDEHYDROGENASE ACTIVITY OF THE LIVER.	Corticosterone	39-53	aldo-keto reductase family 1 member A1	Rattus norvegicus	104-124
14135694-0	1964	[EFFECT OF THE LETHAL DOSE OF ALCOHOL ON THE CORTICOSTERONE CONTENT OF THE BLOOD SERUM AND ON THE ALCOHOL DEHYDROGENASE ACTIVITY OF THE LIVER IN INTACT RATS].	Corticosterone	45-59	aldo-keto reductase family 1 member A1	Rattus norvegicus	98-119
13941688-0	1963	[Forms of urinary elimination of hormones of the cortisol group and corticosterone after administration of ACTH].	Corticosterone	68-82	proopiomelanocortin	Homo sapiens	107-111
4285998-0	1965	Studies on the role of protein synthesis in the regulation of corticosterone production by adrenocorticotropic hormone in vivo.	Corticosterone	62-76	proopiomelanocortin	Homo sapiens	91-118
33872575-10	2021	CORT administration reduced PSD-95, GluA1, and synapsin (synaptic markers) immunocontent, and these alterations were reversed by ascorbic acid or ketamine, but only ketamine reversed the CORT-induced reduction on GluA1 immunocontent.	Corticosterone	0-4	discs large MAGUK scaffold protein 4	Mus musculus	28-34
13489950-2	1957	Action of ACTH on elimination of cortisol and corticosterone catabolites].	Corticosterone	46-60	proopiomelanocortin	Homo sapiens	10-14
33684964-12	2021	CONCLUSIONS AND IMPLICATIONS: The intestinal epithelial glucocorticoid receptor has deleterious effects in experimental colitis induced by DSS, probably related to inhibition of epithelial proliferative responses leading to impaired wound healing and reduced endogenous corticosterone production.	Corticosterone	270-284	nuclear receptor subfamily 3, group C, member 1	Mus musculus	56-79
5836325-0	1965	Effect of aldosterone and corticosterone on beta-galactosidase and invertase activity in the small intestine of rats.	Corticosterone	26-40	galactosidase, beta 1	Rattus norvegicus	44-62
13923797-1	1962	Adrenal corticosterone production resulting from adrenocorticotropic hormone (ACTH) stimulation in vitro depends upon the time of gland removal.	Corticosterone	8-22	pro-opiomelanocortin-alpha	Mus musculus	49-76
13923797-1	1962	Adrenal corticosterone production resulting from adrenocorticotropic hormone (ACTH) stimulation in vitro depends upon the time of gland removal.	Corticosterone	8-22	pro-opiomelanocortin-alpha	Mus musculus	78-82
13923797-3	1962	The responsiveness of the gland to exogenous ACTH is highest when serum corticosterone levels are lowest.	Corticosterone	72-86	pro-opiomelanocortin-alpha	Mus musculus	45-49
33872575-10	2021	CORT administration reduced PSD-95, GluA1, and synapsin (synaptic markers) immunocontent, and these alterations were reversed by ascorbic acid or ketamine, but only ketamine reversed the CORT-induced reduction on GluA1 immunocontent.	Corticosterone	0-4	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	36-41
33872575-10	2021	CORT administration reduced PSD-95, GluA1, and synapsin (synaptic markers) immunocontent, and these alterations were reversed by ascorbic acid or ketamine, but only ketamine reversed the CORT-induced reduction on GluA1 immunocontent.	Corticosterone	0-4	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	213-218
33949202-11	2021	Both groups of animals with minocycline or NIF infusions reversed microglia-mediated synaptic remodeling, and attenuated CORT-induced visceral hypersensitivity.	Corticosterone	121-125	zinc finger protein 335	Rattus norvegicus	43-46
34032349-6	2021	Further, upregulation of macrophage-specific marker antigen F4/80 as well as inflammation-related genes suggested that corticosterone induced inflammation in the testis.	Corticosterone	119-133	adhesion G protein-coupled receptor E1	Mus musculus	60-65
34032349-8	2021	In vitro phagocytosis assays showed that the phagocytic activity in corticosterone-treated Sertoli cells was downregulated and accompanied by decreased mitochondrial membrane potential, while pyruvate dehydrogenase kinase-4 inhibitor supplementation restored this process.	Corticosterone	68-82	pyruvate dehydrogenase kinase, isoenzyme 4	Mus musculus	192-223
34023293-6	2021	Chronic corticosterone (CORT) administration evoked comparable increases in hippocampal MKP-1 protein levels and produced a robust increase in behavioral emotionality.	Corticosterone	8-22	dual specificity phosphatase 1	Rattus norvegicus	88-93
34023293-6	2021	Chronic corticosterone (CORT) administration evoked comparable increases in hippocampal MKP-1 protein levels and produced a robust increase in behavioral emotionality.	Corticosterone	24-28	dual specificity phosphatase 1	Rattus norvegicus	88-93
34023293-9	2021	In a rescue experiment, the effects of CORT on development of depressive-like behaviors and increased NGAL and IL18 protein levels in the kidney were blocked by CRISPR-mediated knockdown of hippocampal Mkp-1 prior to CORT exposure.	Corticosterone	39-43	lipocalin 2	Rattus norvegicus	102-106
34023293-9	2021	In a rescue experiment, the effects of CORT on development of depressive-like behaviors and increased NGAL and IL18 protein levels in the kidney were blocked by CRISPR-mediated knockdown of hippocampal Mkp-1 prior to CORT exposure.	Corticosterone	39-43	interleukin 18	Rattus norvegicus	111-115
34023293-9	2021	In a rescue experiment, the effects of CORT on development of depressive-like behaviors and increased NGAL and IL18 protein levels in the kidney were blocked by CRISPR-mediated knockdown of hippocampal Mkp-1 prior to CORT exposure.	Corticosterone	39-43	dual specificity phosphatase 1	Rattus norvegicus	202-207
34023293-9	2021	In a rescue experiment, the effects of CORT on development of depressive-like behaviors and increased NGAL and IL18 protein levels in the kidney were blocked by CRISPR-mediated knockdown of hippocampal Mkp-1 prior to CORT exposure.	Corticosterone	217-221	interleukin 18	Rattus norvegicus	111-115
34023293-9	2021	In a rescue experiment, the effects of CORT on development of depressive-like behaviors and increased NGAL and IL18 protein levels in the kidney were blocked by CRISPR-mediated knockdown of hippocampal Mkp-1 prior to CORT exposure.	Corticosterone	217-221	dual specificity phosphatase 1	Rattus norvegicus	202-207
33974408-8	2021	The antidepressant also potentiated the corticosterone-induced desensitization of the 5-HT1AR in the dorsal raphe nucleus.	Corticosterone	40-54	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	86-93
33974408-9	2021	Further, chronic fluoxetine increased BDNF mRNA expression in the dentate gyrus of the hippocampus in corticosterone-treated mice of both genotypes.	Corticosterone	102-116	brain derived neurotrophic factor	Mus musculus	38-42
33722706-8	2021	Both Hsd20b2.L and Hsd20b2.S catalyzed the 20beta-reduction of further C21 steroids (17alpha-hydroxyprogesterone, progesterone, 11-deoxycortisol, 11-deoxycorticosterone), while only Hsd20b2.S was able to convert corticosterone and cortisol to their 20beta-reduced metabolites.	Corticosterone	154-168	estradiol 17-beta-dehydrogenase 12-B-like L homeolog	Xenopus laevis	5-12
33722706-8	2021	Both Hsd20b2.L and Hsd20b2.S catalyzed the 20beta-reduction of further C21 steroids (17alpha-hydroxyprogesterone, progesterone, 11-deoxycortisol, 11-deoxycorticosterone), while only Hsd20b2.S was able to convert corticosterone and cortisol to their 20beta-reduced metabolites.	Corticosterone	154-168	estradiol 17-beta-dehydrogenase 12-B-like L homeolog	Xenopus laevis	19-26
33722706-8	2021	Both Hsd20b2.L and Hsd20b2.S catalyzed the 20beta-reduction of further C21 steroids (17alpha-hydroxyprogesterone, progesterone, 11-deoxycortisol, 11-deoxycorticosterone), while only Hsd20b2.S was able to convert corticosterone and cortisol to their 20beta-reduced metabolites.	Corticosterone	154-168	estradiol 17-beta-dehydrogenase 12-B-like L homeolog	Xenopus laevis	19-26
33722534-11	2021	RESULTS: The elevated expression of 11beta-HSD1 contributed to the increased cortisol and corticosterone (CORT) concentrations observed in the ovaries of PCOS patients and PCOS rats respectively.	Corticosterone	90-104	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	36-47
33722534-11	2021	RESULTS: The elevated expression of 11beta-HSD1 contributed to the increased cortisol and corticosterone (CORT) concentrations observed in the ovaries of PCOS patients and PCOS rats respectively.	Corticosterone	106-110	hydroxysteroid 11-beta dehydrogenase 1	Homo sapiens	36-47
33785425-1	2021	OBJECTIVE: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20beta-dihydrocorticosterone (20beta-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute to the cardiometabolic complications of obesity.	Corticosterone	121-135	carbonyl reductase 1	Homo sapiens	11-31
33785425-1	2021	OBJECTIVE: Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20beta-dihydrocorticosterone (20beta-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute to the cardiometabolic complications of obesity.	Corticosterone	121-135	carbonyl reductase 1	Homo sapiens	33-37
34023293-0	2021	Hippocampal mitogen-activated protein kinase phosphatase-1 regulates behavioral and systemic effects of chronic corticosterone administration.	Corticosterone	112-126	dual specificity phosphatase 1	Rattus norvegicus	12-58
33526871-8	2021	Moreover, beta-arrestin2 knockout aggravated the impairment of cell proliferation induced by corticosterone and further blocked the fluoxetine-mediated promotion of mouse hippocampal neurogenesis.	Corticosterone	93-107	arrestin, beta 2	Mus musculus	10-24
33950381-0	2021	Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice.	Corticosterone	46-60	nuclear receptor subfamily 3, group C, member 1	Mus musculus	84-107
33950381-6	2021	Chronic CORT administration downregulated hippocampal GR immunocontent, but this alteration was completely reversed by a single administration of ketamine, but not fluoxetine.	Corticosterone	8-12	nuclear receptor subfamily 3, group C, member 1	Mus musculus	54-56
33950381-9	2021	This study provides novel evidence that a single administration of ketamine, but not fluoxetine, rescued the impairments on GR and dendritic branching in the hippocampus of mice subjected to chronic CORT administration, effects that may be associated with its rapid antidepressant response.	Corticosterone	199-203	nuclear receptor subfamily 3, group C, member 1	Mus musculus	124-126
33449293-8	2021	Elevation of 11betaHSD1 and reduction of 5alpha-reductase expression was observed together with increased hepatic corticosterone concentration and nuclear GR activation.	Corticosterone	114-128	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	13-23
33957303-11	2021	Akin to the gene expression pattern, gluconeogenesis from AAs was synergistically induced by glucagon and corticosterone in a CREB- and GR-dependent manner.	Corticosterone	106-120	cAMP responsive element binding protein 1	Mus musculus	126-130
33957303-11	2021	Akin to the gene expression pattern, gluconeogenesis from AAs was synergistically induced by glucagon and corticosterone in a CREB- and GR-dependent manner.	Corticosterone	106-120	nuclear receptor subfamily 3, group C, member 1	Mus musculus	136-138
33957303-12	2021	CONCLUSIONS: Transcriptional regulation of AA catabolism genes during fasting is widespread and is driven by glucagon (via CREB) and corticosterone (via GR).	Corticosterone	133-147	nuclear receptor subfamily 3, group C, member 1	Mus musculus	153-155
33449293-11	2021	CONCLUSIONS: DHT treatment stimulated hepatic glucocorticoid prereceptor metabolism through increased corticosterone availability which is associated with enhanced GR activation.	Corticosterone	102-116	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	164-166
33862170-12	2021	Compared with the control group, serum basal corticosterone levels were significantly elevated and hippocampal glucocorticoid receptor (GR) amounts and nuclear GR translocation in microglia, but not in neurons or astrocytes, were significantly decreased in the OVA group on P70 but not on P30.	Corticosterone	45-59	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	261-264
33549889-0	2021	Developmental retardation in neonates of aldehyde reductase (AKR1A)-deficient mice is associated with low ascorbic acid and high corticosterone levels.	Corticosterone	129-143	aldo-keto reductase family 1, member B7	Mus musculus	41-59
33930757-4	2021	The aim of this report was to explore molecular mechanisms behind the antidepressant-like oxytocin effect, alone and in synergy with citalopram, on behavioral and molecular level in corticosterone treated rats, a paradigm used to model anxiety and depression in animals.	Corticosterone	182-196	oxytocin/neurophysin I prepropeptide	Homo sapiens	90-98
33930757-5	2021	Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices.	Corticosterone	35-49	oxytocin/neurophysin I prepropeptide	Homo sapiens	0-8
33930757-6	2021	These results support the existence of synergy between citalopram and oxytocin in reversing the molecular and behavioral changes induced by corticosterone treatment and point to possible molecular mechanisms behind antidepressant-like effect of oxytocin.	Corticosterone	140-154	oxytocin/neurophysin I prepropeptide	Homo sapiens	70-78
33930757-5	2021	Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices.	Corticosterone	35-49	parvalbumin	Homo sapiens	98-109
33930757-6	2021	These results support the existence of synergy between citalopram and oxytocin in reversing the molecular and behavioral changes induced by corticosterone treatment and point to possible molecular mechanisms behind antidepressant-like effect of oxytocin.	Corticosterone	140-154	oxytocin/neurophysin I prepropeptide	Homo sapiens	245-253
33866550-7	2021	11-betaHSD1 catalyzes the conversion of inactive cortisone to active cortisol or corticosterone in lungs and liver, while 11-beta-hydroxysteroid dehydrogenase type 2 (11-betaHSD2) has the opposite effect.	Corticosterone	81-95	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	0-11
33930757-5	2021	Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices.	Corticosterone	35-49	oxytocin/neurophysin I prepropeptide	Homo sapiens	275-283
33930757-5	2021	Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices.	Corticosterone	35-49	integrin subunit beta 3	Rattus norvegicus	336-341
33930757-5	2021	Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices.	Corticosterone	35-49	integrin subunit beta 3	Rattus norvegicus	372-377
33930757-5	2021	Oxytocin treatment (1) ameliorated corticosterone-induced reduction of neurogenesis and number of parvalbumin-positive interneurons in the hippocampal CA1 region, (2) enhanced anxiolytic- and antidepressant-like effects of citalopram in the open field test, and (3) the SSRI/oxytocin synergy persisted in reversing the reduction of the Itgb3 gene expression and increased Itgb3/Chl1 ratio in the prefrontal cortices.	Corticosterone	35-49	cell adhesion molecule L1-like	Rattus norvegicus	378-382
33493620-9	2021	Our findings suggest a new role for ASIC-1a mediating the neuromodulator action of histamine and corticosterone regulating specific forms of synaptic plasticity in the mouse ACC.	Corticosterone	97-111	acid-sensing (proton-gated) ion channel 1	Mus musculus	36-43
33864194-15	2022	These results indicate that Ang-II, via the AT-1 receptor, plays a facilitating influence on the cardiovascular response caused by RS; facilitates sympathetic activation and reduces parasympathetic activity related to RS; facilitates the baroreflex activation during RS and favors corticosterone release under this stress model.	Corticosterone	281-295	angiotensinogen	Rattus norvegicus	28-34
33840130-7	2021	Corticosterone administration induced differential GR DNA-binding and regulation of target genes within the hippocampus, largely independent of training.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	51-53
33493620-8	2021	Here we report that modulators like histamine and corticosterone, acting through ASIC-1a regulate synaptic plasticity, reducing the threshold for LTP induction of glutamatergic EPSCs.	Corticosterone	50-64	acid-sensing (proton-gated) ion channel 1	Mus musculus	81-88
33855759-6	2021	Statistically significant differences in the serum concentration of corticosterone, dehydroepiandrosterone, and androstenedione between mothers requiring oxytocin augmentation and the rest of women having spontaneous parturition were found (p = 0.002, p = 0.008, and p = 0.04, respectively).	Corticosterone	68-82	oxytocin/neurophysin I prepropeptide	Homo sapiens	154-162
33855759-10	2021	Association of corticosterone, dehydroepiandrosterone, and androstenedione with the need for the oxytocin infusion usage has been established.	Corticosterone	15-29	oxytocin/neurophysin I prepropeptide	Homo sapiens	97-105
33840130-10	2021	Combination of the GR DNA-binding and transcriptome data identified a set of novel, likely direct, GR target genes that are candidate mediators of corticosterone effects on memory consolidation.	Corticosterone	147-161	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	19-21
33840130-10	2021	Combination of the GR DNA-binding and transcriptome data identified a set of novel, likely direct, GR target genes that are candidate mediators of corticosterone effects on memory consolidation.	Corticosterone	147-161	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	99-101
33556472-8	2021	Ex vivo study revealed that Trem2-/- macrophages significantly promoted the expression of steroidogenic enzymes and increased production of corticosterone.	Corticosterone	140-154	triggering receptor expressed on myeloid cells 2	Mus musculus	28-33
33556472-9	2021	Furthermore, Trem2-/- macrophage-derived exosomes were able to mimic Trem2-/- macrophages in enhancing adrenocortical steroidogenesis CONCLUSIONS: At the early stage of LPS-induced septic shock, corticosterone biosynthesis can be inhibited by macrophage TREM2 in adrenocortical cells, which might partially associate with macrophage-derived exosomes.	Corticosterone	195-209	triggering receptor expressed on myeloid cells 2	Mus musculus	13-18
33556472-7	2021	The expression of steroidogenic enzymes and corticosterone production was assessed RESULTS: Genetic deficiency of TREM2 caused significantly higher corticosterone levels at the early stage of LPS-induced septic shock; whereas TREM2 deficiency neither increased CRH and ACTH nor exacerbated the inflammation in adrenocortical tissue during septic shock.	Corticosterone	148-162	triggering receptor expressed on myeloid cells 2	Mus musculus	114-119
33486334-9	2021	Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-beta1 through high doses of corticosterone, indicating direct cellular immunomodulation.	Corticosterone	114-128	interleukin 10	Mus musculus	65-70
33207294-4	2021	While the closely related glucocorticoid receptor (GR) and its ligand, cortisol (corticosterone in rodents), are established regulators of the circadian clock, new data suggest that the MR can also regulate circadian clock gene expression and timing.	Corticosterone	81-95	nuclear receptor subfamily 3 group C member 1	Homo sapiens	26-49
33207294-4	2021	While the closely related glucocorticoid receptor (GR) and its ligand, cortisol (corticosterone in rodents), are established regulators of the circadian clock, new data suggest that the MR can also regulate circadian clock gene expression and timing.	Corticosterone	81-95	nuclear receptor subfamily 3 group C member 1	Homo sapiens	51-53
33207294-4	2021	While the closely related glucocorticoid receptor (GR) and its ligand, cortisol (corticosterone in rodents), are established regulators of the circadian clock, new data suggest that the MR can also regulate circadian clock gene expression and timing.	Corticosterone	81-95	nuclear receptor subfamily 3 group C member 2	Homo sapiens	186-188
33526603-13	2021	We show that the stressed rat heart produces aldosterone by a novel mechanism involving P450c11AS, Tom22 and intramitochondrial StAR apparently using circulating corticosterone as substrate.	Corticosterone	162-176	steroidogenic acute regulatory protein	Rattus norvegicus	128-132
33469986-7	2021	Significantly, CS increased the corticosterone and BGL but decreased testosterone and epididymal substance levels.	Corticosterone	32-46	citrate synthase	Rattus norvegicus	15-17
33526603-5	2021	Chronic infusion of angiotensin II increased circulating corticosterone levels 350-fold and induced cardiac fibrosis.	Corticosterone	57-71	angiotensinogen	Rattus norvegicus	20-34
33486334-9	2021	Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-beta1 through high doses of corticosterone, indicating direct cellular immunomodulation.	Corticosterone	114-128	transforming growth factor, beta 1	Mus musculus	82-91
33937444-11	2021	At p40, corticosterone release during stress exposure was also positively correlated with GM myelin content in the AMY of male rats.	Corticosterone	8-22	septin 3	Rattus norvegicus	3-6
33790465-0	2021	Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence.	Corticosterone	0-14	growth arrest specific 6	Homo sapiens	24-28
33586968-2	2021	The present study investigated corticosterone (CORT) regulations of extracellular 5-HT in the hippocampal CA3 in a mouse model of depression.	Corticosterone	31-45	carbonic anhydrase 3	Mus musculus	106-109
33790465-5	2021	Mechanistically, corticosterone acts on the dermal papillae to suppress the expression of Gas6, a gene that encodes the secreted factor growth arrest specific 6.	Corticosterone	17-31	growth arrest specific 6	Homo sapiens	90-94
33790465-5	2021	Mechanistically, corticosterone acts on the dermal papillae to suppress the expression of Gas6, a gene that encodes the secreted factor growth arrest specific 6.	Corticosterone	17-31	growth arrest specific 6	Homo sapiens	136-160
33748784-4	2021	Here, we describe a protocol that reproduces mouse cortico-hippocampal circuit in vitro by plating neurons on the microfluidic devices and infecting the neurons with virus-encoding BDNF-mCherry, which allows investigation of the effects of elevated corticosterone levels on BDNF axonal transport.	Corticosterone	249-263	brain derived neurotrophic factor	Mus musculus	181-185
33586968-2	2021	The present study investigated corticosterone (CORT) regulations of extracellular 5-HT in the hippocampal CA3 in a mouse model of depression.	Corticosterone	47-51	carbonic anhydrase 3	Mus musculus	106-109
33655553-7	2021	Interestingly, MeCP2 truncation abolished the sex differences in stress-induced corticosterone release, which was found increased in mutant males, while blunted in mutant females in a zygosity-independent manner.	Corticosterone	80-94	methyl CpG binding protein 2	Mus musculus	15-20
33660857-8	2021	In the nucleus accumbens, corticosterone attenuates dopamine clearance via the organic cation transporter 3 to promote dopamine signaling.	Corticosterone	26-40	OCTN3	Homo sapiens	79-107
33647226-11	2021	Indeed, SR-BI-/- mice were adrenally insufficient during HDM challenge and corticosterone replacement decreased pulmonary neutrophilia and IL-17A production in SR-BI-/- mice.	Corticosterone	75-89	interleukin 17A	Mus musculus	139-145
33647226-11	2021	Indeed, SR-BI-/- mice were adrenally insufficient during HDM challenge and corticosterone replacement decreased pulmonary neutrophilia and IL-17A production in SR-BI-/- mice.	Corticosterone	75-89	scavenger receptor class B, member 1	Mus musculus	160-165
33358979-11	2021	In late gestation, both PBS and OVA-exposed dams had increased corticosterone levels at the end of daily aerosol inductions (GD17) compared to at the start of inductions (GD10).	Corticosterone	63-77	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	32-35
33420760-4	2021	In a second cohort of mice, we measured the expression of 3 genes that code for steroidogenic enzymes that regulate corticosterone levels (Cyp11b1, Hsd11b1, and Hsd11b2) in the HPC, CC, and HYP.	Corticosterone	116-130	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	139-146
33420760-4	2021	In a second cohort of mice, we measured the expression of 3 genes that code for steroidogenic enzymes that regulate corticosterone levels (Cyp11b1, Hsd11b1, and Hsd11b2) in the HPC, CC, and HYP.	Corticosterone	116-130	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	148-155
33420760-4	2021	In a second cohort of mice, we measured the expression of 3 genes that code for steroidogenic enzymes that regulate corticosterone levels (Cyp11b1, Hsd11b1, and Hsd11b2) in the HPC, CC, and HYP.	Corticosterone	116-130	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	161-168
33687272-9	2021	In addition, a diet-dependent effect on hGH-N RNA levels was observed at 36 h after final treatment, but only in the light stage, presumably due to residual effects of DEX treatment and/or recovery of endogenous corticosterone levels.	Corticosterone	212-226	growth hormone 1	Homo sapiens	40-45
33516921-3	2021	We aobserved a specific low level of basal anxiety in TLR5 KO mice with an alteration of the hypothalamo-pituitary axis (HPA) response to acute restraint stress, illustrated by a decrease of both plasma corticosterone level and c-fos expression in the hypothalamic paraventricular nucleus where TLR5 was expressed, compared to WT littermates.	Corticosterone	203-217	toll-like receptor 5	Mus musculus	54-58
33078371-4	2021	The Cd320-/- mouse model presented an impaired learning memory that could be alleviated by a moderate stress, which produced also a greater increase of plasma corticosterone, compared to wild type animals.	Corticosterone	159-173	CD320 antigen	Mus musculus	4-9
33593393-8	2021	Elevated plasma POMC and ACTH-corticosterone dissociation were confirmed in the mouse model.	Corticosterone	30-44	pro-opiomelanocortin-alpha	Mus musculus	25-29
33726625-10	2021	Pretreatment with PACAP increased active coping style in the FST, despite higher levels of ACTH and corticosterone.	Corticosterone	100-114	adenylate cyclase activating polypeptide 1	Rattus norvegicus	18-23
33372063-0	2021	Corticosterone Attenuates Reward-seeking Behavior and Increases Anxiety via D2 Receptor Signaling in Ventral Tegmental Area Dopamine Neurons.	Corticosterone	0-14	dopamine receptor D2	Mus musculus	76-87
33592009-7	2021	Our results revealed that at the nadir of corticosterone secretion in the resting state the cbg-/- mouse hippocampus exhibited slightly elevated levels of free-corticosterone, diminished FK506 binding protein 5 expression, increased corticosterone downstream effectors and altered MAPK and PI3K pathway with increased pY216-GSK3beta and phosphorylated tau.	Corticosterone	42-56	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	92-95
33592009-7	2021	Our results revealed that at the nadir of corticosterone secretion in the resting state the cbg-/- mouse hippocampus exhibited slightly elevated levels of free-corticosterone, diminished FK506 binding protein 5 expression, increased corticosterone downstream effectors and altered MAPK and PI3K pathway with increased pY216-GSK3beta and phosphorylated tau.	Corticosterone	160-174	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	92-95
33592009-7	2021	Our results revealed that at the nadir of corticosterone secretion in the resting state the cbg-/- mouse hippocampus exhibited slightly elevated levels of free-corticosterone, diminished FK506 binding protein 5 expression, increased corticosterone downstream effectors and altered MAPK and PI3K pathway with increased pY216-GSK3beta and phosphorylated tau.	Corticosterone	160-174	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	92-95
33594318-9	2021	In a in-vivo mouse model of Cushing"s disease, HIF1alpha inhibitor reduced HIF1alpha and GR protein levels, reduced tumor size and lowered the plasma concentrations of ACTH and corticosterone.	Corticosterone	177-191	hypoxia inducible factor 1, alpha subunit	Mus musculus	47-56
33671898-9	2021	Moreover, IF modulated glucose homeostasis parameters, with a significant decrease (p < 0.05) in insulin resistance and downregulation of serum corticosterone level.	Corticosterone	144-158	cobalamin binding intrinsic factor	Rattus norvegicus	10-12
33496327-11	2021	Plasma TNF-alpha, IL-6 and corticosterone levels were higher increased in IL-10-/- than control mice.	Corticosterone	27-41	interleukin 10	Mus musculus	74-79
33303970-4	2021	Serum cortisol and corticosterone levels, i.e., human and rodent stress markers, were correlated with serum bile acid levels in patients with NAFLD and methionine- and choline-deficient (MCD) diet-induced mice, respectively, suggesting that stress is related to bile acid (BA) homeostasis in NASH.	Corticosterone	19-33	glucosidase beta 2	Mus musculus	108-117
33582145-6	2021	Despite altered LD storage, mobilization of adrenal LDs and secretion of corticosterone induced by adrenocorticotropic hormone stimulation or starvation were similar in Plin2+/+ and Plin2-/- mice.	Corticosterone	73-87	pro-opiomelanocortin-alpha	Mus musculus	99-126
33162397-7	2021	RESULTS: Global deletion of 11beta-HSD1 resulted in a profound GC resistance in animals receiving corticosterone, characterised by persistent synovitis, joint destruction and inflammatory leucocyte infiltration.	Corticosterone	98-112	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	28-39
33628224-9	2021	When SCGN expression in the PVN was functionally knocked down by a constructed CsCI virus, we found that SCGN knockdown decreased the serum CRH, ACTH, and CORT levels in the SCGN shRNA+hepatectomy group compared with the hepatectomy group, and it also attenuated CRH expression in the PVN.	Corticosterone	155-159	secretagogin, EF-hand calcium binding protein	Homo sapiens	5-9
33628224-9	2021	When SCGN expression in the PVN was functionally knocked down by a constructed CsCI virus, we found that SCGN knockdown decreased the serum CRH, ACTH, and CORT levels in the SCGN shRNA+hepatectomy group compared with the hepatectomy group, and it also attenuated CRH expression in the PVN.	Corticosterone	155-159	secretagogin, EF-hand calcium binding protein	Homo sapiens	105-109
33628224-9	2021	When SCGN expression in the PVN was functionally knocked down by a constructed CsCI virus, we found that SCGN knockdown decreased the serum CRH, ACTH, and CORT levels in the SCGN shRNA+hepatectomy group compared with the hepatectomy group, and it also attenuated CRH expression in the PVN.	Corticosterone	155-159	secretagogin, EF-hand calcium binding protein	Homo sapiens	105-109
33303970-6	2021	Considering that a short stress enhanced hepatic CYP7A1 protein levels in normal mice and corticosterone increased CYP7A1 protein levels in primary mouse hepatocytes, the enhanced Cyp7a1 expression was postulated to be involved in the chronic stress-increased hepatic betaMCA level.	Corticosterone	90-104	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	115-121
33303970-6	2021	Considering that a short stress enhanced hepatic CYP7A1 protein levels in normal mice and corticosterone increased CYP7A1 protein levels in primary mouse hepatocytes, the enhanced Cyp7a1 expression was postulated to be involved in the chronic stress-increased hepatic betaMCA level.	Corticosterone	90-104	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	180-186
33519376-0	2020	The Molecular Mechanism of Chronic High-Dose Corticosterone-Induced Aggravation of Cognitive Impairment in APP/PS1 Transgenic Mice.	Corticosterone	45-59	presenilin 1	Mus musculus	111-114
32512138-4	2021	We here report that both, long-term GC deprivation (by adrenalectomy) and exogenous GC administration with natural or synthetic glucocorticoid receptor ligands (corticosterone and dexamethasone, respectively) induce Tau hyperphosphorylation in the hippocampus and frontocortical regions at epitopes associated with disruption of cytoskeletal and synaptic function.	Corticosterone	161-175	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	128-151
33164233-7	2021	Moreover, GEN administration inhibited the protein levels of p-BTK, TLR4, MyD88, p-NF-kappaB in corticosterone-induced PC12 cell.	Corticosterone	96-110	Bruton tyrosine kinase	Rattus norvegicus	63-66
33164233-7	2021	Moreover, GEN administration inhibited the protein levels of p-BTK, TLR4, MyD88, p-NF-kappaB in corticosterone-induced PC12 cell.	Corticosterone	96-110	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-92
33404580-5	2021	Using partial least squares (PLS) modeling of in vitro and in vivo datasets, we found that the level of Tph1 mRNA in RIN14B significantly correlated with the performance of a forced swim test and sucrose preference test, and serum corticosterone level in chronically stressed mice.	Corticosterone	231-245	tryptophan hydroxylase 1	Mus musculus	104-108
33473105-7	2021	Consistent with these results, NIX enhancer pre-treatment of a corticosterone-exposed mouse elevates mitophagy and synaptic density in hippocampus, improving the outcome of a spatial memory task.	Corticosterone	63-77	BCL2/adenovirus E1B interacting protein 3-like	Mus musculus	31-34
33152342-0	2021	Responses to chronic corticosterone on brain glucocorticoid receptors, adrenal gland, and gut microbiota in mice lacking neuronal serotonin.	Corticosterone	21-35	nuclear receptor subfamily 3, group C, member 1	Mus musculus	45-69
33438026-7	2021	RESULTS: Brain-wide SST+ cell silencing induced features of stress-related illnesses, including elevated neuronal activity and plasma corticosterone levels, increased anxiety- and anhedonia-like behaviors, and impaired short-term memory.	Corticosterone	134-148	somatostatin	Mus musculus	20-23
33509094-0	2021	Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive-like behaviors and deficits in startle responses.	Corticosterone	47-61	period circadian clock 2	Mus musculus	32-36
33584538-0	2020	Androgen Receptor Is Dispensable for X-Zone Regression in the Female Adrenal but Regulates Post-Partum Corticosterone Levels and Protects Cortex Integrity.	Corticosterone	103-117	androgen receptor	Mus musculus	0-17
33584538-6	2020	Results show that AR-signaling is dispensable for adrenal gland development in females, and for X-zone regression during pregnancy, but is required to suppress elevation of corticosterone levels post-partum.	Corticosterone	173-187	androgen receptor	Mus musculus	18-20
33519376-5	2020	Long-term administration of CORT accelerated cognitive dysfunction by increasing the production and deposition of beta-amyloid (Abeta).	Corticosterone	28-32	amyloid beta (A4) precursor protein	Mus musculus	128-133
33519376-8	2020	Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells.	Corticosterone	67-71	nuclear receptor subfamily 3, group C, member 1	Mus musculus	14-37
33519376-8	2020	Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells.	Corticosterone	67-71	nuclear receptor subfamily 3, group C, member 1	Mus musculus	39-41
33519376-8	2020	Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells.	Corticosterone	67-71	beta-site APP cleaving enzyme 1	Mus musculus	112-118
33519376-8	2020	Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells.	Corticosterone	67-71	presenilin 1	Mus musculus	123-126
33519376-8	2020	Moreover, the glucocorticoid receptor (GR) mediated the effects of CORT on the stimulation of the expression of BACE-1 and PS1 via the PKA and CREB pathways in neuroblastoma N2a cells.	Corticosterone	67-71	cAMP responsive element binding protein 1	Mus musculus	143-147
33035630-0	2020	Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-kappaB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway.	Corticosterone	36-50	NFE2 like bZIP transcription factor 2	Rattus norvegicus	161-165
33007359-5	2020	This study examined if reductions in self-administration following MR antagonist treatment were related to dysregulation of MR-mediated corticosterone negative feedback.	Corticosterone	136-150	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	124-126
33267881-10	2020	CONCLUSION: Carotid sinus nerve electrostimulation attenuates inflammation and protects against lipopolysaccharide-induced endotoxaemic shock via increased corticosterone acting on the glucocorticoid receptor of myeloid immune cells.	Corticosterone	156-170	nuclear receptor subfamily 3, group C, member 1	Mus musculus	185-208
32800933-7	2020	The negative correlation of plasma corticosterone levels with spleen mass further indicated a role of corticosterone in the modulation of the spleen function, probably via nr3c2 gene encoded mineralocorticoid receptors.	Corticosterone	35-49	nuclear receptor subfamily 3 group C member 2	Homo sapiens	172-177
32800933-7	2020	The negative correlation of plasma corticosterone levels with spleen mass further indicated a role of corticosterone in the modulation of the spleen function, probably via nr3c2 gene encoded mineralocorticoid receptors.	Corticosterone	102-116	nuclear receptor subfamily 3 group C member 2	Homo sapiens	172-177
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Corticosterone	247-261	interleukin 18	Homo sapiens	46-51
32638280-10	2021	There was also a positive correlation between IL-18 or IL-1beta and 17-alpha-hydroxypregnenolone, 17-alpha-hydroxyprogesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, testosterone, dihydrotestosterone, progesterone, corticosterone, 11-deoxycorticosterone, and the ratio of DHEAS/cortisol.	Corticosterone	247-261	interleukin 1 alpha	Homo sapiens	55-63
33349836-7	2020	The results showed that the levels of epinephrine and CORT in the serum of the rats in CS group were significantly increased compared with those in the control group (P < 0.05).	Corticosterone	54-58	citrate synthase	Rattus norvegicus	87-89
33007359-2	2020	The MR is a steroid receptor in the same family as the glucocorticoid receptor, with which it shares the ligand corticosterone in addition to the MR selective ligand aldosterone.	Corticosterone	112-126	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	4-6
33007359-2	2020	The MR is a steroid receptor in the same family as the glucocorticoid receptor, with which it shares the ligand corticosterone in addition to the MR selective ligand aldosterone.	Corticosterone	112-126	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	55-78
33070362-3	2020	One of the genes most highly downregulated (~4.8 fold) in Src-1/-2 dKO fetal lungs encodes 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which catalyzes conversion of inactive 11-dehydrocorticosterone to the glucocorticoid receptor (GR) ligand, corticosterone.	Corticosterone	198-212	nuclear receptor coactivator 1	Mus musculus	58-63
33070362-3	2020	One of the genes most highly downregulated (~4.8 fold) in Src-1/-2 dKO fetal lungs encodes 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which catalyzes conversion of inactive 11-dehydrocorticosterone to the glucocorticoid receptor (GR) ligand, corticosterone.	Corticosterone	198-212	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	91-133
33070362-3	2020	One of the genes most highly downregulated (~4.8 fold) in Src-1/-2 dKO fetal lungs encodes 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), which catalyzes conversion of inactive 11-dehydrocorticosterone to the glucocorticoid receptor (GR) ligand, corticosterone.	Corticosterone	198-212	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	135-146
33035630-0	2020	Liquiritin protects PC12 cells from corticosterone-induced neurotoxicity via regulation of metabolic disorders, attenuation ERK1/2-NF-kappaB pathway, activation Nrf2-Keap1 pathway, and inhibition mitochondrial apoptosis pathway.	Corticosterone	36-50	Kelch-like ECH-associated protein 1	Rattus norvegicus	166-171
32780722-4	2020	Mechanistically, we found impaired hypothalamic-pituitary-adrenal axis feedback, blunted sympathetic responsiveness, and chronically elevated corticosterone levels driven by hypothalamic hyperactivation of Jnk signaling.	Corticosterone	142-156	mitogen-activated protein kinase 8	Mus musculus	206-209
33058849-9	2020	In vitro study noted that corticosterone challenge compromised cardiomyocyte function, provoked lipid peroxidation and mitochondrial injury, the effects of which were nullified by Beclin1 haploinsufficiency, inhibitors of lipoxygenase, ferroptosis and autophagy.	Corticosterone	26-40	beclin 1, autophagy related	Mus musculus	180-187
33058849-11	2020	CONCLUSION: These data suggest that Beclin1 haploinsufficiency protects against cold exposure-induced cardiac dysfunction possibly through corticosterone- and ferroptosis-mediated mechanisms.	Corticosterone	139-153	beclin 1, autophagy related	Mus musculus	36-43
33155081-7	2020	These findings suggest that DHM can protect primary hippocampal astrocytes cultured with HG + SP + CORT from P2X7 receptor-mediated damage.	Corticosterone	99-103	purinergic receptor P2X 7	Homo sapiens	109-122
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	Corticosterone	37-51	brain derived neurotrophic factor	Mus musculus	94-98
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	Corticosterone	37-51	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	99-103
33265983-0	2020	2-Phenylethylamine (PEA) Ameliorates Corticosterone-Induced Depression-Like Phenotype via the BDNF/TrkB/CREB Signaling Pathway.	Corticosterone	37-51	cAMP responsive element binding protein 1	Mus musculus	104-108
33265983-4	2020	Here, we show that PEA exerts antidepressant effects by modulating the Brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element binding protein (CREB) signaling pathway in CORT-induced depression.	Corticosterone	215-219	brain derived neurotrophic factor	Mus musculus	71-104
33265983-4	2020	Here, we show that PEA exerts antidepressant effects by modulating the Brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element binding protein (CREB) signaling pathway in CORT-induced depression.	Corticosterone	215-219	brain derived neurotrophic factor	Homo sapiens	106-110
33265983-4	2020	Here, we show that PEA exerts antidepressant effects by modulating the Brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element binding protein (CREB) signaling pathway in CORT-induced depression.	Corticosterone	215-219	neurotrophic receptor tyrosine kinase 2	Homo sapiens	143-147
33265983-4	2020	Here, we show that PEA exerts antidepressant effects by modulating the Brain-derived neurotrophic factor (BDNF)/tropomyosin receptor kinase B (TrkB)/cAMP response element binding protein (CREB) signaling pathway in CORT-induced depression.	Corticosterone	215-219	cAMP responsive element binding protein 1	Homo sapiens	188-192
33265983-9	2020	We found that CORT injection promoted depression-like behavior and significantly decreased BDNF and TrkB expression in the hippocampus.	Corticosterone	14-18	brain derived neurotrophic factor	Mus musculus	91-95
33265983-9	2020	We found that CORT injection promoted depression-like behavior and significantly decreased BDNF and TrkB expression in the hippocampus.	Corticosterone	14-18	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	100-104
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	Corticosterone	130-134	brain derived neurotrophic factor	Mus musculus	77-81
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	Corticosterone	130-134	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	82-86
33265983-11	2020	Our findings reveal that PEA exerts antidepressant effects by modulating the BDNF/TrkB/CREB signaling pathway in a mouse model of CORT-induced depression.	Corticosterone	130-134	cAMP responsive element binding protein 1	Mus musculus	87-91
32946951-4	2020	Using a murine model in which NCK1 is inactivated, we show that male, but not female, mice display increased levels of context-dependent anxiety-like behaviours along with an increase in circulating serum corticosterone relative to control.	Corticosterone	205-219	non-catalytic region of tyrosine kinase adaptor protein 1	Mus musculus	30-34
33111138-9	2020	Decreased plasma corticosterone and fearfulness were accompanied by altered hypothalamic gene mRNA expressions of BDNF, NR2A, GR, and CRH through the HPA axis in response to altered gut microbial compositions and functions.	Corticosterone	17-31	brain derived neurotrophic factor	Gallus gallus	114-118
33313251-0	2020	Xiaoyaosan (Tiaogan-Liqi therapy) protects peritoneal macrophages from corticosterone-induced stress by regulating the interaction between glucocorticoid receptor and ABCA1.	Corticosterone	71-85	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	139-162
33313251-0	2020	Xiaoyaosan (Tiaogan-Liqi therapy) protects peritoneal macrophages from corticosterone-induced stress by regulating the interaction between glucocorticoid receptor and ABCA1.	Corticosterone	71-85	ATP binding cassette subfamily A member 1	Rattus norvegicus	167-172
33313251-13	2020	Furthermore, overexpression of GR attenuated the protective function of XYS on CORT-induced stress in PMs, while overexpression of ABCA1 enhanced that.	Corticosterone	79-83	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	31-33
33313251-14	2020	Conclusions: This study denoted that XYS could protect PMs from CORT-induced stress by regulating the interaction of GR and ABCA1, which might contribute to the treatment of atherosclerosis.	Corticosterone	64-68	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	117-119
33313251-14	2020	Conclusions: This study denoted that XYS could protect PMs from CORT-induced stress by regulating the interaction of GR and ABCA1, which might contribute to the treatment of atherosclerosis.	Corticosterone	64-68	ATP binding cassette subfamily A member 1	Rattus norvegicus	124-129
32574519-0	2020	Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala.	Corticosterone	92-106	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-16
32574519-0	2020	Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala.	Corticosterone	92-106	cAMP responsive element binding protein 1	Rattus norvegicus	23-27
32574519-0	2020	Changes in c-fos and p-CREB signaling following exposure to forced swim stress or exogenous corticosterone during morphine-induced place preference are dependent on glucocorticoid receptor in the basolateral amygdala.	Corticosterone	92-106	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	165-188
32574519-2	2020	Our previous behavioral data showed that forced swim stress (FSS) and corticosterone administration could inhibit the acquisition of morphine-induced conditioned place preference (CPP), and this effect was blocked by intra-basolateral amygdala (BLA) administration of RU38486, glucocorticoid receptor (GR) antagonist.	Corticosterone	70-84	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	277-300
32574519-2	2020	Our previous behavioral data showed that forced swim stress (FSS) and corticosterone administration could inhibit the acquisition of morphine-induced conditioned place preference (CPP), and this effect was blocked by intra-basolateral amygdala (BLA) administration of RU38486, glucocorticoid receptor (GR) antagonist.	Corticosterone	70-84	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	302-304
32574519-3	2020	Therefore, we tried to evaluate the effect of intra-BLA administration of the GR antagonist during the conditioning phase on the c-fos and p-CREB/CREB ratio expression in the AMY, NAc, PFC, and HIP of rats that underwent FSS or received exogenous corticosterone (10mg/kg;ip) before morphine injection (5mg/kg;sc) during three conditioning days.	Corticosterone	247-261	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	78-80
32574519-6	2020	In the PFC, in addition to FSS, corticosterone could raise c-fos expression, which was blocked by RU38486.	Corticosterone	32-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
32978833-3	2020	In the pregnant rat model, we firstly confirmed that administration of 11beta-HSD2 inhibitor carbenoxolone (CBX) subcutaneously or by placenta-targeted delivery system could lead to a decrease in placental 11beta-HSD2 expression and activity and an increase in corticosterone level in placenta and maternal circulation.	Corticosterone	261-275	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	71-82
32918762-7	2020	SPS or Cort injection inhibits embryo implantation by interfering Lif signaling and stimulating the uterine deposition of collagen types I, III, and IV on day 4 of pregnancy.	Corticosterone	7-11	leukemia inhibitory factor	Mus musculus	66-69
32918762-8	2020	Uterine decidualization is also attenuated by SPS or Cort injection through suppressing Cox-2 expression.	Corticosterone	53-57	cytochrome c oxidase II, mitochondrial	Mus musculus	88-93
33111138-9	2020	Decreased plasma corticosterone and fearfulness were accompanied by altered hypothalamic gene mRNA expressions of BDNF, NR2A, GR, and CRH through the HPA axis in response to altered gut microbial compositions and functions.	Corticosterone	17-31	nuclear receptor subfamily 3 group C member 1	Gallus gallus	126-128
33111138-9	2020	Decreased plasma corticosterone and fearfulness were accompanied by altered hypothalamic gene mRNA expressions of BDNF, NR2A, GR, and CRH through the HPA axis in response to altered gut microbial compositions and functions.	Corticosterone	17-31	corticotropin releasing hormone	Gallus gallus	134-137
32926224-6	2020	The enzyme-linked immunosorbent assay (ELISA) and immunoblot analysis were used to determine the levels of cAMP or cGMP and expression of pCREB or BDNF, respectively, in the corticosterone-treated HT-22 cells.	Corticosterone	174-188	brain derived neurotrophic factor	Mus musculus	147-151
32926224-9	2020	Hcyb1 also rescued corticosterone-induced decreases in both cGMP and cAMP levels, pCREB/CREB and BDNF expression.	Corticosterone	19-33	cAMP responsive element binding protein 1	Mus musculus	83-87
32926224-9	2020	Hcyb1 also rescued corticosterone-induced decreases in both cGMP and cAMP levels, pCREB/CREB and BDNF expression.	Corticosterone	19-33	brain derived neurotrophic factor	Mus musculus	97-101
33100225-10	2020	In contrast, low-dose corticosterone but not methylprednisolone played a protective role by upregulating mineralocorticoid receptor (MR) activation.	Corticosterone	22-36	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	105-131
33100225-13	2020	In contrast, refilling of MR by corticosterone protects PVN neurons and reduces the incidence of CIRCI by promoting GR/MR rebalancing after TBI.	Corticosterone	32-46	glutathione-disulfide reductase	Rattus norvegicus	116-121
33106576-6	2020	Chia seeds improved spatial learning deficits but not impaired cognitive flexibility, potentially mediated by amelioration of glucose tolerance, attenuation of corticosterone levels and reversal of SRD-induced elevation of pro-inflammatory cytokine levels.	Corticosterone	160-174	chitinase, acidic 1	Mus musculus	0-4
33025573-0	2021	Bag-1 Mediates Glucocorticoid Receptor Trafficking to Mitochondria after Corticosterone Stimulation: Potential Role in Regulating Affective Resilience.	Corticosterone	73-87	BAG cochaperone 1	Rattus norvegicus	0-5
33037288-7	2020	Correlation between miR-132 and plasma corticosterone concentrations resulted in the highest correlation coefficient, when compared to the analysis of miR-375, miR-203 and miR-30b.	Corticosterone	39-53	microRNA 132	Mus musculus	20-27
33025573-0	2021	Bag-1 Mediates Glucocorticoid Receptor Trafficking to Mitochondria after Corticosterone Stimulation: Potential Role in Regulating Affective Resilience.	Corticosterone	73-87	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	15-38
33025573-5	2021	Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 minutes and 24 hours.	Corticosterone	0-14	BAG cochaperone 1	Rattus norvegicus	55-60
33025573-5	2021	Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 minutes and 24 hours.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	61-63
33025573-5	2021	Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 minutes and 24 hours.	Corticosterone	0-14	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	86-88
33025573-5	2021	Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 minutes and 24 hours.	Corticosterone	16-20	BAG cochaperone 1	Rattus norvegicus	55-60
33025573-5	2021	Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 minutes and 24 hours.	Corticosterone	16-20	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	61-63
33025573-5	2021	Corticosterone (CORT) treatment significantly enhanced Bag-1/GR complex formation and GR mitochondrial translocation in cultured rat cortical neurons after treatment for 30 minutes and 24 hours.	Corticosterone	16-20	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	86-88
33025573-6	2021	By contrast, after stimulation with CORT for 3 days, localization of the Bag-1/GR complex and mitochondrial GR were reduced.	Corticosterone	36-40	BAG cochaperone 1	Rattus norvegicus	73-78
33025573-6	2021	By contrast, after stimulation with CORT for 3 days, localization of the Bag-1/GR complex and mitochondrial GR were reduced.	Corticosterone	36-40	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	79-81
33025573-6	2021	By contrast, after stimulation with CORT for 3 days, localization of the Bag-1/GR complex and mitochondrial GR were reduced.	Corticosterone	36-40	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	108-110
33025573-7	2021	Similar results were obtained in mice, in which administrated CORT in drinking water for 21 days significantly impaired the GR levels in the mitochondria, while Bag-1 overexpression rescued this reduction.	Corticosterone	62-66	nuclear receptor subfamily 3, group C, member 1	Mus musculus	124-126
33025573-8	2021	Furthermore, chronic CORT exposure led to anhedonia-like and depression-like behaviors in the sucrose-consumption test and forced swimming test, and these behaviors were rescued by Bag-1 overexpression.	Corticosterone	21-25	BCL2-associated athanogene 1	Mus musculus	181-186
32535229-4	2020	Furthermore, levels of serum corticosterone and hepatic glucocorticoid-activation system (mainly including expression of 11beta-HSD1, GR, and C/EBPalpha as well as 11beta-HSD1/11beta-HSD2 ratio) were high in fetal rats of PEE but low or unchanged in adult offspring.	Corticosterone	29-43	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	164-187
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	28-32	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	98-109
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	28-32	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	128-151
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	28-32	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	153-155
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	28-32	histone deacetylase 11	Rattus norvegicus	235-257
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	28-32	histone deacetylase 11	Rattus norvegicus	259-265
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	28-32	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	278-289
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	344-348	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	98-109
32757222-9	2020	Moreover, the high level of CORT induced by PCE downregulated the H3K9ac and expression levels of 11beta-HSD2 through promoting glucocorticoid receptor (GR) into the nucleus of bone marrow mesenchymal stem cells (BMSCs) and recruiting histone deacetylase 11 (HDAC11) binding to 11beta-HSD2 promoter region, which further enhanced the effect of CORT on suppressing osteogenic function of BMSCs.	Corticosterone	344-348	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	153-155
32652267-10	2020	The behavioral response obtained by the combined administration of these drugs was paralleled by the reestablishment of the CORT-induced molecular alterations on hippocampal GR, NF-kappaB, IDO-1, and GLT-1 immunocontent.	Corticosterone	124-128	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	178-187
32652267-10	2020	The behavioral response obtained by the combined administration of these drugs was paralleled by the reestablishment of the CORT-induced molecular alterations on hippocampal GR, NF-kappaB, IDO-1, and GLT-1 immunocontent.	Corticosterone	124-128	indoleamine 2,3-dioxygenase 1	Mus musculus	189-194
32652267-10	2020	The behavioral response obtained by the combined administration of these drugs was paralleled by the reestablishment of the CORT-induced molecular alterations on hippocampal GR, NF-kappaB, IDO-1, and GLT-1 immunocontent.	Corticosterone	124-128	solute carrier family 1 (glial high affinity glutamate transporter), member 2	Mus musculus	200-205
32574576-10	2020	We identified Adamts9 as a potential contributor to response to CORT+DFP and found links to symptoms of GWI.	Corticosterone	64-68	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 9	Mus musculus	14-21
32669383-9	2020	These findings were supported by in vitro experiments in primary murine astrocyte cultures, indicating that IL-6 decreases production of allopregnanolone and increases corticosterone levels.	Corticosterone	168-182	interleukin 6	Mus musculus	108-112
32669383-10	2020	Our results indicate that age-related increases in IL-6 levels reduce progesterone substrate availability, resulting in a decline in allopregnanolone levels and an increase in corticosterone.	Corticosterone	176-190	interleukin 6	Mus musculus	51-55
32391653-8	2020	In a dorsal root ganglion (DRG)-derived cell line, corticosterone rapidly (within 30 minutes) induced membrane expression of TRPM8.	Corticosterone	51-65	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	125-130
32997989-6	2020	The expression of a key NADPH synthase, hexose-6-phosphate dehydrogenase (H6PD), was inhibited by the low plasma corticosterone level after surgery.	Corticosterone	113-127	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	40-72
32663551-0	2020	Cyclical Administration of Corticosterone Results in Aggravation of Depression-like Behaviors and Accompanying Downregulations in Reelin in an Animal Model of Chronic Stress Relevant to Human Recurrent Depression.	Corticosterone	27-41	reelin	Homo sapiens	130-136
32997989-6	2020	The expression of a key NADPH synthase, hexose-6-phosphate dehydrogenase (H6PD), was inhibited by the low plasma corticosterone level after surgery.	Corticosterone	113-127	hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)	Rattus norvegicus	74-78
32765692-1	2020	11beta-hydroxysteroid dehydrogenase-2 (11beta-HSD2) is one of the key enzymes in glucocorticoid metabolism, which can inactivate local corticosterone and regulate the level of active glucocorticoid in tissues.	Corticosterone	135-149	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	39-50
33344708-9	2020	Adolescent exposure to CORT treatment also significantly altered somatostatin and parvalbumin dendrite branch level and the combined effect of Met/Met genotype and CORT treatment significantly reduced somatostatin and parvalbumin dendrite spine density.	Corticosterone	23-27	parvalbumin	Mus musculus	218-229
32995659-7	2020	Therefore, we examined the effects of corticosterone and IGF-1 on regulation of fractalkine and CX3CR1 expression.	Corticosterone	38-52	chemokine (C-X3-C motif) ligand 1	Mus musculus	80-91
32995659-7	2020	Therefore, we examined the effects of corticosterone and IGF-1 on regulation of fractalkine and CX3CR1 expression.	Corticosterone	38-52	chemokine (C-X3-C motif) receptor 1	Mus musculus	96-102
32995659-11	2020	These findings indicate that impaired cognition in STZ-treated mice is associated with reduced fractalkine-CX3CR1 signaling in the hippocampus which may be induced by an increase in corticosterone and a decrease in IGF-1.	Corticosterone	182-196	chemokine (C-X3-C motif) ligand 1	Mus musculus	95-106
32995659-11	2020	These findings indicate that impaired cognition in STZ-treated mice is associated with reduced fractalkine-CX3CR1 signaling in the hippocampus which may be induced by an increase in corticosterone and a decrease in IGF-1.	Corticosterone	182-196	chemokine (C-X3-C motif) receptor 1	Mus musculus	107-113
32932938-5	2020	A single stress exposure produced a significant increase in the expression of corticosterone reactivator, 11-beta-hydroxysteroid dehydrogenase 1 (11beta-Hsd1), while the 11beta-Hsd2 isozyme and corticosteroid-binding globulin were down-regulated following stress, indicative of an elevated availability of active corticosterone.	Corticosterone	78-92	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	106-144
32982757-4	2020	Reelin and ketamine similarly rescue synaptic expression of mTOR and p-mTOR that were decreased by corticosterone.	Corticosterone	99-113	reelin	Rattus norvegicus	0-6
32982757-4	2020	Reelin and ketamine similarly rescue synaptic expression of mTOR and p-mTOR that were decreased by corticosterone.	Corticosterone	99-113	mechanistic target of rapamycin kinase	Rattus norvegicus	60-64
32982757-4	2020	Reelin and ketamine similarly rescue synaptic expression of mTOR and p-mTOR that were decreased by corticosterone.	Corticosterone	99-113	mechanistic target of rapamycin kinase	Rattus norvegicus	71-75
33344708-9	2020	Adolescent exposure to CORT treatment also significantly altered somatostatin and parvalbumin dendrite branch level and the combined effect of Met/Met genotype and CORT treatment significantly reduced somatostatin and parvalbumin dendrite spine density.	Corticosterone	23-27	somatostatin	Mus musculus	65-77
33344708-9	2020	Adolescent exposure to CORT treatment also significantly altered somatostatin and parvalbumin dendrite branch level and the combined effect of Met/Met genotype and CORT treatment significantly reduced somatostatin and parvalbumin dendrite spine density.	Corticosterone	23-27	parvalbumin	Mus musculus	82-93
33344708-9	2020	Adolescent exposure to CORT treatment also significantly altered somatostatin and parvalbumin dendrite branch level and the combined effect of Met/Met genotype and CORT treatment significantly reduced somatostatin and parvalbumin dendrite spine density.	Corticosterone	164-168	somatostatin	Mus musculus	201-213
33344708-9	2020	Adolescent exposure to CORT treatment also significantly altered somatostatin and parvalbumin dendrite branch level and the combined effect of Met/Met genotype and CORT treatment significantly reduced somatostatin and parvalbumin dendrite spine density.	Corticosterone	164-168	parvalbumin	Mus musculus	218-229
32943610-0	2020	Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-beta responses by Mfn2-mediated ubiquitin degradation of MAVS.	Corticosterone	64-78	interferon beta 1	Homo sapiens	87-102
32943610-0	2020	Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-beta responses by Mfn2-mediated ubiquitin degradation of MAVS.	Corticosterone	64-78	mitofusin 2	Homo sapiens	116-120
32943610-0	2020	Novel insights into stress-induced susceptibility to influenza: corticosterone impacts interferon-beta responses by Mfn2-mediated ubiquitin degradation of MAVS.	Corticosterone	64-78	mitochondrial antiviral signaling protein	Homo sapiens	155-159
32943610-5	2020	Mechanistically, the effect of CORT was mediated by proteasome-dependent degradation of MAVS, thereby resulting in the impediment of MAVS-transduced IFN-beta generation in vivo and in vitro.	Corticosterone	31-35	mitochondrial antiviral signaling protein	Mus musculus	88-92
32943610-5	2020	Mechanistically, the effect of CORT was mediated by proteasome-dependent degradation of MAVS, thereby resulting in the impediment of MAVS-transduced IFN-beta generation in vivo and in vitro.	Corticosterone	31-35	mitochondrial antiviral signaling protein	Mus musculus	133-137
32943610-5	2020	Mechanistically, the effect of CORT was mediated by proteasome-dependent degradation of MAVS, thereby resulting in the impediment of MAVS-transduced IFN-beta generation in vivo and in vitro.	Corticosterone	31-35	interferon alpha	Mus musculus	149-157
32497592-9	2020	Maternal CORT treatment reduced maternal hippocampal IFN-gamma, and both hippocampal and plasma TNF-alpha.	Corticosterone	9-13	interferon gamma	Homo sapiens	53-62
32497592-9	2020	Maternal CORT treatment reduced maternal hippocampal IFN-gamma, and both hippocampal and plasma TNF-alpha.	Corticosterone	9-13	tumor necrosis factor	Homo sapiens	96-105
32937768-10	2020	Anxiety parameters and corticosterone concentrations were greatest in the CS condition.	Corticosterone	23-37	citrate synthase	Rattus norvegicus	74-76
32932938-5	2020	A single stress exposure produced a significant increase in the expression of corticosterone reactivator, 11-beta-hydroxysteroid dehydrogenase 1 (11beta-Hsd1), while the 11beta-Hsd2 isozyme and corticosteroid-binding globulin were down-regulated following stress, indicative of an elevated availability of active corticosterone.	Corticosterone	78-92	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	146-157
32932938-5	2020	A single stress exposure produced a significant increase in the expression of corticosterone reactivator, 11-beta-hydroxysteroid dehydrogenase 1 (11beta-Hsd1), while the 11beta-Hsd2 isozyme and corticosteroid-binding globulin were down-regulated following stress, indicative of an elevated availability of active corticosterone.	Corticosterone	78-92	serpin family A member 6	Rattus norvegicus	194-225
32932938-5	2020	A single stress exposure produced a significant increase in the expression of corticosterone reactivator, 11-beta-hydroxysteroid dehydrogenase 1 (11beta-Hsd1), while the 11beta-Hsd2 isozyme and corticosteroid-binding globulin were down-regulated following stress, indicative of an elevated availability of active corticosterone.	Corticosterone	313-327	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	146-157
32585162-0	2020	Cholecalciferol abolishes depressive-like behavior and hippocampal glucocorticoid receptor impairment induced by chronic corticosterone administration in mice.	Corticosterone	121-135	nuclear receptor subfamily 3, group C, member 1	Mus musculus	67-90
32908490-0	2020	GPER-Deficient Rats Exhibit Lower Serum Corticosterone Level and Increased Anxiety-Like Behavior.	Corticosterone	40-54	G protein-coupled estrogen receptor 1	Rattus norvegicus	0-4
31677354-2	2020	In rodents 11betaHSD1 converts inert 11-dehydrocorticosterone (11-DHC), to the active form, corticosterone (CORT).	Corticosterone	47-61	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	11-21
31677354-2	2020	In rodents 11betaHSD1 converts inert 11-dehydrocorticosterone (11-DHC), to the active form, corticosterone (CORT).	Corticosterone	108-112	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	11-21
32663519-11	2020	in vitro, corticosterone could induce the H3K9 deacetylation of the TGFbeta signaling pathway, thus inhibiting the expression of the TGFbeta signaling pathway and extracellular matrix.	Corticosterone	10-24	transforming growth factor alpha	Rattus norvegicus	68-75
32663519-11	2020	in vitro, corticosterone could induce the H3K9 deacetylation of the TGFbeta signaling pathway, thus inhibiting the expression of the TGFbeta signaling pathway and extracellular matrix.	Corticosterone	10-24	transforming growth factor alpha	Rattus norvegicus	133-140
32872446-6	2020	We found that CRS influenced the release of corticosterone induced by ARS and inhibited the ability of ARS to activate mature BDNF, its receptor Tropomyosin receptor kinase B (TRKB), and their associated intracellular cascades: the TRKB-PI3K-AKT), the MEK-MAPK/ERK, and the Phospholipase C gamma (PLCgamma) pathways, positively modulated by ARS in non-stressed animals.	Corticosterone	44-58	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	176-180
32908490-3	2020	Genetic ablation of GPER in the rat resulted in significantly lower basal serum corticosterone level but enhanced ACTH release in response to acute restraint stress, especially in the female.	Corticosterone	80-94	G protein-coupled estrogen receptor 1	Rattus norvegicus	20-24
32512137-5	2020	Furthermore, corticosterone administration into male rats as a rodent model of depression induced significantly higher c-Fos expression in 5-HT3AR-positive GABAergic neurons compared to that in 5-HT neurons within the DRN.	Corticosterone	13-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	119-124
33005133-8	2020	Third, these opposite effects of CORT on fear memory are both mediated by glucocorticoid receptor (GR) activation, and reproduced by post-conditioning stress or systemic CORT injection.	Corticosterone	33-37	nuclear receptor subfamily 3, group C, member 1	Mus musculus	74-97
33005133-8	2020	Third, these opposite effects of CORT on fear memory are both mediated by glucocorticoid receptor (GR) activation, and reproduced by post-conditioning stress or systemic CORT injection.	Corticosterone	33-37	nuclear receptor subfamily 3, group C, member 1	Mus musculus	99-101
33061795-8	2020	Corticosterone treatment induced a marked increase in FoxO3a levels, while decreased the expression of NPW protein in the hypothalamus.	Corticosterone	0-14	forkhead box O3	Rattus norvegicus	54-60
33061795-8	2020	Corticosterone treatment induced a marked increase in FoxO3a levels, while decreased the expression of NPW protein in the hypothalamus.	Corticosterone	0-14	neuropeptide W	Rattus norvegicus	103-106
32487763-3	2020	We measured mitochondrial respiration, ROS generation and protein abundance as well as alpha-synuclein pathology in male mice.Chronic corticosterone administration induced mitochondrial hyperactivity in the amygdala.	Corticosterone	134-148	synuclein, alpha	Mus musculus	87-102
32487763-4	2020	Although injection of alpha-synuclein pre-formed fibrils into the striatum resulted in pronounced alpha-synuclein pathology in both striatum and amygdala, mitochondrial respiration in these brain regions was not compromised, regardless of corticosterone treatment.Our results suggest that early stage alpha-synuclein pathology does not influence mitochondrial respiration in the striatum and amygdala, even in corticosterone-induced respirational hyperactivity.	Corticosterone	410-424	synuclein, alpha	Mus musculus	22-37
32487763-5	2020	We discuss our findings in light of relevant literature, warn of a potential publication bias and encourage scientists to report their negative results within the framework of this model.Significance statement We report that early stage alpha-synuclein pathology by itself or in combination with exogenous corticosterone-induced amygdala hyperactivity did not compromise mitochondrial respiration in the striatum and amygdala in one of the most commonly used models of synucleinopathies.	Corticosterone	306-320	synuclein, alpha	Mus musculus	237-252
32922257-10	2020	In addition, we also found five central nervous system-related phenotypes and fecal corticosterone concentration have significant correlation (p < 0.05) with expression of Ccr6 in the PFC.	Corticosterone	84-98	chemokine (C-C motif) receptor 6	Mus musculus	172-176
32755573-6	2020	Mice lacking Gpr35 in CX3CR1+ macrophages aggravate colitis when exposed to dextran sodium sulfate, which is associated with decreased transcript levels of the corticosterone-generating gene Cyp11b1 and macrophage-derived Tnf.	Corticosterone	160-174	G protein-coupled receptor 35	Mus musculus	13-18
32755573-6	2020	Mice lacking Gpr35 in CX3CR1+ macrophages aggravate colitis when exposed to dextran sodium sulfate, which is associated with decreased transcript levels of the corticosterone-generating gene Cyp11b1 and macrophage-derived Tnf.	Corticosterone	160-174	cytochrome P450, family 11, subfamily b, polypeptide 1	Mus musculus	191-198
32755573-7	2020	Administration of TNF in these mice restores Cyp11b1 expression and intestinal corticosterone production and ameliorates DSS-induced colitis.	Corticosterone	79-93	tumor necrosis factor	Mus musculus	18-21
32343840-11	2020	Moreover, ZLc-002 and Tat-CAPON12C increased synaptogenesis along with improved dendritic remodelling in CMS mice or CORT-treated cultured neurons.	Corticosterone	117-121	tyrosine aminotransferase	Mus musculus	22-25
32534838-6	2020	Unexpectedly, we found that offspring of TMT-exposed males are more active, exhibit less anxiety-like behavior, and have decreased baseline plasma corticosterone relative to controls.	Corticosterone	147-161	tryptase gamma 1	Mus musculus	41-44
32592984-9	2020	The protein-protein interactions (PPI) analysis showed HSPA8, HSPA2 and IL8L1 as key core nodes had 7 interactions and may play important roles in the regulation of CORT-induced stress effects on immune function.	Corticosterone	165-169	heat shock protein family A (Hsp70) member 8	Gallus gallus	55-60
32592984-9	2020	The protein-protein interactions (PPI) analysis showed HSPA8, HSPA2 and IL8L1 as key core nodes had 7 interactions and may play important roles in the regulation of CORT-induced stress effects on immune function.	Corticosterone	165-169	heat shock protein family A (Hsp70) member 2	Gallus gallus	62-67
32592984-9	2020	The protein-protein interactions (PPI) analysis showed HSPA8, HSPA2 and IL8L1 as key core nodes had 7 interactions and may play important roles in the regulation of CORT-induced stress effects on immune function.	Corticosterone	165-169	interleukin 8-like 1	Gallus gallus	72-77
32378057-5	2020	Our results showed that CORT induced ERS and upregulated the expression of proBDNF and its receptor, Follistatin-like protein 4 (FSTL4), which contributed to significantly decreased neuronal viability and expression of synaptic-related proteins including NR2A, PSD95, and SYN.	Corticosterone	24-28	follistatin-like 4	Mus musculus	101-127
32378057-5	2020	Our results showed that CORT induced ERS and upregulated the expression of proBDNF and its receptor, Follistatin-like protein 4 (FSTL4), which contributed to significantly decreased neuronal viability and expression of synaptic-related proteins including NR2A, PSD95, and SYN.	Corticosterone	24-28	follistatin-like 4	Mus musculus	129-134
32378057-5	2020	Our results showed that CORT induced ERS and upregulated the expression of proBDNF and its receptor, Follistatin-like protein 4 (FSTL4), which contributed to significantly decreased neuronal viability and expression of synaptic-related proteins including NR2A, PSD95, and SYN.	Corticosterone	24-28	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	Mus musculus	255-259
32378057-5	2020	Our results showed that CORT induced ERS and upregulated the expression of proBDNF and its receptor, Follistatin-like protein 4 (FSTL4), which contributed to significantly decreased neuronal viability and expression of synaptic-related proteins including NR2A, PSD95, and SYN.	Corticosterone	24-28	discs large MAGUK scaffold protein 4	Mus musculus	261-266
32378057-5	2020	Our results showed that CORT induced ERS and upregulated the expression of proBDNF and its receptor, Follistatin-like protein 4 (FSTL4), which contributed to significantly decreased neuronal viability and expression of synaptic-related proteins including NR2A, PSD95, and SYN.	Corticosterone	24-28	joined toes	Mus musculus	272-275
32378057-8	2020	Our study presented evidence that CORT-induced ERS negatively regulated the neuronal viability and the level of synaptic-related protein of primary neurons via the proBDNF/FSTL4 pathway.	Corticosterone	34-38	follistatin-like 4	Mus musculus	172-177
32399718-0	2020	Protective Effects of Agmatine Against Corticosterone-Induced Impairment on Hippocampal mTOR Signaling and Cell Death.	Corticosterone	39-53	mechanistic target of rapamycin kinase	Mus musculus	88-92
32751911-5	2020	Negr1 was down-regulated by escitalopram in the hypothalamus of FSL rats, by fluoxetine in the hippocampal dentate gyrus of corticosterone-treated mice, and by nortriptyline in hippocampal primary neurons.	Corticosterone	124-138	neuronal growth regulator 1	Rattus norvegicus	0-5
32399718-9	2020	Additionally, reduced phosphorylation of mTOR (Ser2448), a pro-survival protein that is active when phosphorylated at Ser2448, was observed in the whole hippocampal DG in corticosterone-treated mice, an effect not observed in agmatine or fluoxetine-treated mice.	Corticosterone	171-185	mechanistic target of rapamycin kinase	Mus musculus	41-45
32399718-11	2020	Altogether, the results indicate that agmatine, similar to fluoxetine, was able to counteract corticosterone-induced impairment on mTOR signaling and cell death in hippocampal DG.	Corticosterone	94-108	mechanistic target of rapamycin kinase	Mus musculus	131-135
32705829-6	2020	After treatment, the treatment group had significant reductions in the serum levels of CRH, ACTH and CORT (P<0.05,P <0.01), and compared with the control group, the treatment group had significant reductions in the serum levels of CRH, ACTH and CORT (P<0.01,P<0.05).	Corticosterone	245-249	corticotropin releasing hormone	Homo sapiens	231-234
32709996-9	2021	This gradient-like effect was also observed on GR nuclear translocation in response to corticosterone or dexamethasone.	Corticosterone	87-101	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	47-49
32709996-10	2021	Long-term exposure to corticosterone or dexamethasone treatment also tended to induce a greater downregulation of GR-associated genes in vHi-derived neurons compared to those from the dHi and iHi.	Corticosterone	22-36	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	114-116
32469228-10	2020	Suppression of corticosterone synthesis by PhADX increased basal plasma levels of ACTH, aldosterone and plasma renin activity in unstressed animals but there was no further increase of these hormones following stressor exposure.	Corticosterone	15-29	renin	Rattus norvegicus	111-116
33344699-6	2020	Both lipopolysaccharide (LPS) and corticosterone treatment caused depression-like symptoms and increased miR-34a expression.	Corticosterone	34-48	microRNA 34a	Mus musculus	105-112
32640230-0	2020	Chronic Corticosterone Elevation Suppresses Adult Hippocampal Neurogenesis by Hyperphosphorylating Huntingtin.	Corticosterone	8-22	huntingtin	Mus musculus	99-109
32640230-4	2020	Parallel studies in mice show that CORT induces phosphorylation of these same residues, reduces BDNF levels, and suppresses neurogenesis.	Corticosterone	35-39	brain derived neurotrophic factor	Mus musculus	96-100
32665640-2	2020	Corticosteroids such as aldosterone or corticosterone increase the L-type Ca2+ current (ICaL) in the heart via the mineralocorticoid receptor (MR).	Corticosterone	39-53	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	115-141
32665640-2	2020	Corticosteroids such as aldosterone or corticosterone increase the L-type Ca2+ current (ICaL) in the heart via the mineralocorticoid receptor (MR).	Corticosterone	39-53	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	143-145
32640230-1	2020	Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis.	Corticosterone	100-114	brain derived neurotrophic factor	Mus musculus	161-194
32640230-1	2020	Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis.	Corticosterone	100-114	brain derived neurotrophic factor	Mus musculus	196-200
32640230-1	2020	Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis.	Corticosterone	116-120	brain derived neurotrophic factor	Mus musculus	161-194
32802177-0	2020	Autophagic degradation of PML promotes susceptibility to HSV-1 by stress-induced corticosterone.	Corticosterone	81-95	PML nuclear body scaffold	Homo sapiens	26-29
32802177-9	2020	Furthermore, PML protein level in HSV-1 infected brain tissues and neural cells was remarkably decreased by stress treatment in vivo or CORT treatment in vitro, while its transcriptional level was not affected.	Corticosterone	136-140	PML nuclear body scaffold	Homo sapiens	13-16
32802177-10	2020	Notably, a striking decline in protein expressions of ICP27 and gB was observed in PML-overexpressing cells, which was reversed by CORT treatment.	Corticosterone	131-135	PML nuclear body scaffold	Homo sapiens	83-86
32802177-14	2020	The expressions of viral proteins were reduced in LC3-depleted cells, and the degradation of PML by CORT-induced autophagy was prevented in cells with LC3 knockdown by RNAi.	Corticosterone	100-104	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	50-53
32802177-14	2020	The expressions of viral proteins were reduced in LC3-depleted cells, and the degradation of PML by CORT-induced autophagy was prevented in cells with LC3 knockdown by RNAi.	Corticosterone	100-104	PML nuclear body scaffold	Homo sapiens	93-96
32802177-14	2020	The expressions of viral proteins were reduced in LC3-depleted cells, and the degradation of PML by CORT-induced autophagy was prevented in cells with LC3 knockdown by RNAi.	Corticosterone	100-104	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	151-154
32640230-1	2020	Chronic exposure to stress is a major risk factor for neuropsychiatric disease, and elevated plasma corticosterone (CORT) correlates with reduced levels of both brain-derived neurotrophic factor (BDNF) and hippocampal neurogenesis.	Corticosterone	116-120	brain derived neurotrophic factor	Mus musculus	196-200
31282111-9	2020	In addition, the pre-treatment with the CRF1 receptor antagonist CP-154 526 before naloxone conditioning session impaired morphine withdrawal-induced aversive memory acquisition, the increased corticosterone plasma levels, and the expression of BDNF observed after CPA expression in the DG and BLA.	Corticosterone	193-207	corticotropin releasing hormone receptor 1	Mus musculus	40-53
31990732-13	2020	Plasma corticosterone levels were elevated in both sexes on day 14 after CFA compared to day 1, suggesting autologous downregulation of the GR by corticosterone may have contributed to the downregulation observed on day 14 but not day 1.	Corticosterone	7-21	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	140-142
32774242-5	2020	Here we show that repeated injections of corticosterone inhibited hippocampal neurogenesis and impaired dendritic morphology of neurons in the dentate gyrus of both wild-type and adiponectin-knockout mice comparably, which subsequently evoked depression-like behaviors.	Corticosterone	41-55	adiponectin, C1Q and collagen domain containing	Mus musculus	179-190
31990732-13	2020	Plasma corticosterone levels were elevated in both sexes on day 14 after CFA compared to day 1, suggesting autologous downregulation of the GR by corticosterone may have contributed to the downregulation observed on day 14 but not day 1.	Corticosterone	146-160	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	140-142
32156515-4	2020	We have found that 5-days treatment with methylprednisolone suppresses basal ACTH and corticosterone secretion, as well as corticosterone secretion in response to a high dose of ACTH, and down-regulates key genes in the adrenal steroidogenic pathway, including StAR, MRAP, CYP11a1 and CYP11b1.	Corticosterone	123-137	proopiomelanocortin	Homo sapiens	178-182
32553391-0	2020	GPR39 protects against corticosterone-induced neuronal injury in hippocampal cells through the CREB-BDNF signaling pathway.	Corticosterone	23-37	G protein-coupled receptor 39	Mus musculus	0-5
32553391-0	2020	GPR39 protects against corticosterone-induced neuronal injury in hippocampal cells through the CREB-BDNF signaling pathway.	Corticosterone	23-37	cAMP responsive element binding protein 1	Mus musculus	95-99
32553391-0	2020	GPR39 protects against corticosterone-induced neuronal injury in hippocampal cells through the CREB-BDNF signaling pathway.	Corticosterone	23-37	brain derived neurotrophic factor	Mus musculus	100-104
32553391-5	2020	The effects of GPR39 on CORT-induced stress injury were analyzed by both siRNA and agonist (TC-G-1008).	Corticosterone	24-28	G protein-coupled receptor 39	Mus musculus	15-20
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	mechanistic target of rapamycin kinase	Homo sapiens	50-79
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	nuclear receptor subfamily 3 group C member 1	Homo sapiens	81-104
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	106-116
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	neuropeptide Y	Homo sapiens	118-132
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	neuropeptide Y	Homo sapiens	133-136
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	serine/threonine kinase 11	Homo sapiens	139-154
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	serine/threonine kinase 11	Homo sapiens	156-160
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	163-173
32599620-7	2020	CORT treatment upregulated the gene expression of mammalian target of rapamycin, glucocorticoid receptor, AMPKalpha2, neuropeptide Y(NPY), liver kinase B1 (LKB1), AMPKalpha1, and fatty acid synthase in the hypothalamus.	Corticosterone	0-4	fatty acid synthase	Homo sapiens	179-198
32599620-9	2020	Hence, CORT administration in the diet activated the LKB1-AMPK-NPY/ACC signaling pathway in the hypothalamus of broiler.	Corticosterone	7-11	serine/threonine kinase 11	Homo sapiens	53-57
32599620-9	2020	Hence, CORT administration in the diet activated the LKB1-AMPK-NPY/ACC signaling pathway in the hypothalamus of broiler.	Corticosterone	7-11	neuropeptide Y	Homo sapiens	63-66
32485668-8	2020	Culture with corticosterone induced apoptosis and activated the TNF-alpha system in MGCs.	Corticosterone	13-27	tumor necrosis factor	Mus musculus	64-73
32298774-8	2020	The expression level of Pomc in the anterior pituitary significantly increased, accompanied by increased plasma corticosterone levels, at days 6, 12, and 18 after immunization.	Corticosterone	112-126	proopiomelanocortin	Rattus norvegicus	24-28
32485668-10	2020	However, culture with corticosterone downregulated TNF-alpha expression significantly in oviductal epithelial cells.	Corticosterone	22-36	tumor necrosis factor	Mus musculus	51-60
31591928-3	2020	While corticosterone (CORT) is a primary factor inhibiting IL-1 expression, progesterone (PROG) is also released by the adrenal glands in male rats in response to stress and also has potent anti-inflammatory properties.	Corticosterone	6-20	cortistatin	Rattus norvegicus	22-26
33344693-7	2020	Adcy1 tg mice show higher corticosterone and lower basal glucocorticoid receptor (GR) expression, along with a higher MR (mineralocorticoid receptor) to GR ratio in the hippocampus.	Corticosterone	26-40	adenylate cyclase 1	Mus musculus	0-5
32570881-0	2020	Taurine and Ginsenoside Rf Induce BDNF Expression in SH-SY5Y Cells: A Potential Role of BDNF in Corticosterone-Triggered Cellular Damage.	Corticosterone	96-110	brain derived neurotrophic factor	Homo sapiens	88-92
31958644-7	2020	Cortisol, 11-deoxycortisol, cortisone, corticosterone, and 11-deoxycorticosterone showed a significant increase after ACTH stimulation.	Corticosterone	39-53	pro-opiomelanocortin	Equus caballus	118-122
32570881-3	2020	In addition, taurine and ginsenoside Rf protected cells from corticosterone-induced BDNF suppression and reduced cell viability and lactate dehydrogenase release.	Corticosterone	61-75	brain derived neurotrophic factor	Homo sapiens	84-88
32539318-0	2021	Clinical and genetic characteristics of patients with corticosterone methyloxidase deficiency type 2: Novel mutations in CYP11B2.	Corticosterone	54-68	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	121-128
32040016-0	2020	Glucocorticoid and brain-derived neurotrophic factor relationship: a brief investigation into the model of depression by chronic administration of corticosterone.	Corticosterone	147-161	brain derived neurotrophic factor	Homo sapiens	19-52
32278229-4	2020	TCRbeta-/-delta-/- mice showed an increased baseline plasma corticosterone and exaggerated changes in stress-related gene expression after repeated restraint stress.	Corticosterone	60-74	T cell receptor alpha chain	Mus musculus	0-15
32463582-6	2020	This could be explained by an impaired expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), an enzyme that determines the extent of cellular glucocorticoid responses by reducing the corticosteroids cortisone/11-dehydrocorticosterone to their active forms cortisol/corticosterone, in aged macrophages and peripheral leukocytes.	Corticosterone	250-264	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	66-108
32463582-6	2020	This could be explained by an impaired expression and activity of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1), an enzyme that determines the extent of cellular glucocorticoid responses by reducing the corticosteroids cortisone/11-dehydrocorticosterone to their active forms cortisol/corticosterone, in aged macrophages and peripheral leukocytes.	Corticosterone	250-264	hydroxysteroid 11-beta dehydrogenase 1	Mus musculus	110-121
32040016-9	2020	We also found a positive correlation between the expression of glucocorticoid receptor and tyrosine-receptor kinase B and our results suggest a possible relationship between the glucocorticoid/glucocorticoid receptor and brain-derived neurotrophic factor/tropomyosin-receptor kinase B routes after chronic corticosterone administration.	Corticosterone	306-320	nuclear receptor subfamily 3 group C member 1	Homo sapiens	63-86
32040016-9	2020	We also found a positive correlation between the expression of glucocorticoid receptor and tyrosine-receptor kinase B and our results suggest a possible relationship between the glucocorticoid/glucocorticoid receptor and brain-derived neurotrophic factor/tropomyosin-receptor kinase B routes after chronic corticosterone administration.	Corticosterone	306-320	nuclear receptor subfamily 3 group C member 1	Homo sapiens	193-216
32304685-8	2020	Rip IV treatment significantly ameliorated the cognitive deficit induced by Cort and displayed a neuroprotective effect.	Corticosterone	76-80	regulation of phenobarbitol-inducible P450	Mus musculus	0-3
32492799-6	2020	Incubation of primary hippocampal neurons with corticosterone downregulated miR-26a, an effect that mirrored our in vivo results, as miR-26a was downregulated in the hippocampus as well as in blood serum-derived small extracellular vesicles (sEVs) of rats exposed to two different stress paradigms by movement restriction (i.e., stress by restraint in cages or by complete immobilization in bags).	Corticosterone	47-61	microRNA 26a	Rattus norvegicus	76-83
32492799-6	2020	Incubation of primary hippocampal neurons with corticosterone downregulated miR-26a, an effect that mirrored our in vivo results, as miR-26a was downregulated in the hippocampus as well as in blood serum-derived small extracellular vesicles (sEVs) of rats exposed to two different stress paradigms by movement restriction (i.e., stress by restraint in cages or by complete immobilization in bags).	Corticosterone	47-61	microRNA 26a	Rattus norvegicus	133-140
32199975-5	2020	Moreover, the high level of corticosterone caused by PCE reduced the H3K9ac level on TGFbetaR1 promoter region through acting on glucocorticoids receptor (GR) and recruiting histone deacetylase 2 (HDAC2) into the nucleus of fetal chondrocytes.	Corticosterone	28-42	glutathione-disulfide reductase	Rattus norvegicus	129-153
32199975-5	2020	Moreover, the high level of corticosterone caused by PCE reduced the H3K9ac level on TGFbetaR1 promoter region through acting on glucocorticoids receptor (GR) and recruiting histone deacetylase 2 (HDAC2) into the nucleus of fetal chondrocytes.	Corticosterone	28-42	glutathione-disulfide reductase	Rattus norvegicus	155-157
32199975-5	2020	Moreover, the high level of corticosterone caused by PCE reduced the H3K9ac level on TGFbetaR1 promoter region through acting on glucocorticoids receptor (GR) and recruiting histone deacetylase 2 (HDAC2) into the nucleus of fetal chondrocytes.	Corticosterone	28-42	histone deacetylase 2	Rattus norvegicus	174-195
32199975-5	2020	Moreover, the high level of corticosterone caused by PCE reduced the H3K9ac level on TGFbetaR1 promoter region through acting on glucocorticoids receptor (GR) and recruiting histone deacetylase 2 (HDAC2) into the nucleus of fetal chondrocytes.	Corticosterone	28-42	histone deacetylase 2	Rattus norvegicus	197-202
32199975-6	2020	Taken together, PCE induced osteoarthritis susceptibility in male adult offspring rats, which was attributed to the low-functional programming of TGFbetaR1 induced by corticosterone via GR/HDAC2 signaling.	Corticosterone	167-181	glutathione-disulfide reductase	Rattus norvegicus	186-188
32199975-6	2020	Taken together, PCE induced osteoarthritis susceptibility in male adult offspring rats, which was attributed to the low-functional programming of TGFbetaR1 induced by corticosterone via GR/HDAC2 signaling.	Corticosterone	167-181	histone deacetylase 2	Rattus norvegicus	189-194
32304685-9	2020	CONCLUSION: The antidepressant-like ability of Rip IV treatment against chronic Cort-induced stress may be due to its potential to mitigate inflammatory damage and oxidative stress.	Corticosterone	80-84	regulation of phenobarbitol-inducible P450	Mus musculus	47-50
32508525-0	2020	Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase.	Corticosterone	0-14	NLR family, pyrin domain containing 3	Mus musculus	36-41
31366299-8	2020	The expression of five proteins related to AGE in the thymus reflected the observed pattern of general locomotor activity, RGS, and plasma corticosterone levels.	Corticosterone	139-153	renin binding protein	Rattus norvegicus	43-46
32229097-5	2020	Tissue glucocorticoid levels are regulated by 11beta-hydroxysteroid dehydrogenase type1 (11betaHSD1), which increases the local concentration of active glucocorticoids by the production of corticosterone from 11-dehydrocorticosterone.	Corticosterone	189-203	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	46-87
32229097-5	2020	Tissue glucocorticoid levels are regulated by 11beta-hydroxysteroid dehydrogenase type1 (11betaHSD1), which increases the local concentration of active glucocorticoids by the production of corticosterone from 11-dehydrocorticosterone.	Corticosterone	189-203	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	89-99
32229097-7	2020	OBJECTIVES: To investigate the effect of chronic alterations of ARC corticosterone levels (mediated by 11betaHSD1) on food intake and body weight in adult male rats.	Corticosterone	68-82	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	103-113
32229097-14	2020	CONCLUSIONS: Therefore ARC corticosterone, regulated by 11betaHSD1, may play a role in food intake and body weight regulation.	Corticosterone	27-41	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	56-66
32059939-7	2020	Mast-L reduced plasma corticosterone and lowered the scoring function at GABAA -18.48 kcal/mol (Ki = 155 nM), 5-HT1A -22.39 kcal/mol (Ki = 130 nM), corticotropin-releasing factor receptor subtype 1 (CRF1) -11.95 kcal/mol (Ki = 299 nM) and glucocorticoid receptors (GR) -14.69 kcal/mol (Ki = 3552 nM).	Corticosterone	22-36	microtubule associated serine/threonine kinase-like	Mus musculus	0-6
32486390-4	2020	DAT-/- rats show profound dysregulation of pituitary homeostasis, in the presence of elevated peripheral corticosterone, before and after acute restraint stress.	Corticosterone	105-119	solute carrier family 6 member 3	Rattus norvegicus	0-3
32508525-0	2020	Corticosterone Inhibits LPS-Induced NLRP3 Inflammasome Priming in Macrophages by Suppressing Xanthine Oxidase.	Corticosterone	0-14	xanthine dehydrogenase	Mus musculus	93-109
32508525-3	2020	This study is aimed at investigating the modulation of NLRP3 inflammasome priming by endogenous glucocorticoids (corticosterone, CORT) and its relationship with xanthine oxidase (XO).	Corticosterone	113-127	NLR family, pyrin domain containing 3	Mus musculus	55-60
32344830-0	2020	Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms.	Corticosterone	0-14	high mobility group box 1	Rattus norvegicus	23-28
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	23-37	Kruppel-like factor 9	Xenopus tropicalis	98-102
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	23-37	Kruppel-like factor 9	Xenopus tropicalis	104-125
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	23-37	Usher syndrome 1G (autosomal recessive)	Xenopus tropicalis	153-158
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	39-43	Kruppel-like factor 9	Xenopus tropicalis	98-102
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	39-43	Kruppel-like factor 9	Xenopus tropicalis	104-125
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	39-43	Usher syndrome 1G (autosomal recessive)	Xenopus tropicalis	153-158
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	77-81	Kruppel-like factor 9	Xenopus tropicalis	98-102
32032606-4	2020	Induction by exogenous corticosterone (CORT, the frog stress hormone) of the CORT response genes, klf9 (Kruppel-like factor 9, also regulated by TH) and ush1g (Usher"s syndrome 1G), was completely abrogated in GRKO tadpoles.	Corticosterone	77-81	Kruppel-like factor 9	Xenopus tropicalis	104-125
31899262-5	2020	Surprisingly, NMU-8 administration significantly decreased plasma corticosterone concentrations.	Corticosterone	66-80	neuromedin U	Mus musculus	14-17
31899262-9	2020	Interestingly, NMU-8 administration also significantly decreased plasma corticosterone concentrations in mice that were exposed to single forced swim stress, while this effect was no longer observed when mice were exposed to forced swim stress for a second time.	Corticosterone	72-86	neuromedin U	Mus musculus	15-18
32344830-0	2020	Corticosterone Induces HMGB1 Release in Primary Cultured Rat Cortical Astrocytes: Involvement of Pannexin-1 and P2X7 Receptor-Dependent Mechanisms.	Corticosterone	0-14	Pannexin 1	Rattus norvegicus	97-107
32344830-5	2020	Significant HMGB1 was released with treatment with either corticosterone or dexamethasone, a synthetic glucocorticoid.	Corticosterone	58-72	high mobility group box 1	Rattus norvegicus	12-17
32344830-6	2020	HMGB1 translocated from the nucleus to the cytoplasm following corticosterone treatment.	Corticosterone	63-77	high mobility group box 1	Rattus norvegicus	0-5
32344830-8	2020	In addition, inhibition of pannexin-1, and P2X7 receptors led to a significant decrease in corticosterone-induced HMGB1 release.	Corticosterone	91-105	Pannexin 1	Rattus norvegicus	27-37
32344830-8	2020	In addition, inhibition of pannexin-1, and P2X7 receptors led to a significant decrease in corticosterone-induced HMGB1 release.	Corticosterone	91-105	high mobility group box 1	Rattus norvegicus	114-119
32344830-9	2020	Taken together, corticosterone stimulates astrocytic glucocorticoid receptors and triggers cytoplasmic translocation and extracellular release of nuclear HMGB1 through a mechanism involving pannexin-1 and P2X7 receptors.	Corticosterone	16-30	high mobility group box 1	Rattus norvegicus	154-159
32344830-9	2020	Taken together, corticosterone stimulates astrocytic glucocorticoid receptors and triggers cytoplasmic translocation and extracellular release of nuclear HMGB1 through a mechanism involving pannexin-1 and P2X7 receptors.	Corticosterone	16-30	Pannexin 1	Rattus norvegicus	190-200
32362809-9	2020	Moreover, chronic corticosterone administration was sufficient to mimic the effect of CSDS on the tonic inhibition of Thy1+ and Thy1- PNs.	Corticosterone	18-32	thymus cell antigen 1, theta	Mus musculus	118-122
32303568-12	2020	Plasma corticosterone and adrenocorticotropic hormone levels were significantly greater in the animals treated with PACAP compared with vehicle after CLP.	Corticosterone	7-21	adenylate cyclase activating polypeptide 1	Mus musculus	116-121
32362809-9	2020	Moreover, chronic corticosterone administration was sufficient to mimic the effect of CSDS on the tonic inhibition of Thy1+ and Thy1- PNs.	Corticosterone	18-32	thymus cell antigen 1, theta	Mus musculus	128-132
32300655-5	2020	TRPV1-dependent calcium influx into the cells of adrenal cortex and medulla is sufficient to drive rapid release of corticosterone and (nor)epinephrine.	Corticosterone	116-130	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
31930968-9	2020	Corticosterone did not affect PER2 rhythm of the SCN samples, but caused a phase shift in PER2 expression in liver samples.	Corticosterone	0-14	period circadian clock 2	Mus musculus	90-94
32014487-6	2020	The PAL modulation of HPA axis reflected at different levels: inhibition of hypothalamic CRF expression and reduction in plasma levels of adrenocorticotropin and corticosterone.	Corticosterone	162-176	Shc SH2-domain binding protein 1	Mus musculus	4-7
31897576-6	2020	Furthermore, NI RLN3 depletion disrupted corticosterone regulation, increased oxytocin and arginine-vasopressin, but not corticotropin-releasing factor, mRNA, in PVN, and decreased basal levels of c-fos mRNA in parvocellular and magnocellular PVN, bed nucleus of stria terminalis and the lateral hypothalamic area, brain regions involved in stress and feeding.	Corticosterone	41-55	relaxin 3	Rattus norvegicus	16-20
32193397-6	2020	Using chemogenetic manipulation, we further demonstrate specific roles for this circuitry in the daily control of heart rate and corticosterone secretion, collectively establishing SCN VIP cells as influential regulators of physiological timing.	Corticosterone	129-143	vasoactive intestinal peptide	Homo sapiens	185-188
31953122-1	2020	Following a stressful event, the hypothalamus-pituitary-adrenal axis mediates the release of the stress hormone cortisol (corticosterone in rodents; CORT).	Corticosterone	122-136	cortistatin	Rattus norvegicus	149-153
32244957-7	2020	The action mechanism of the GRA may be either by interfering with GR deactivation or by restoring the balance between pro- and anti-inflammatory signaling pathways driven by the complementary mineralocorticoid receptor (MR)- and GR-mediated actions of corticosterone.	Corticosterone	252-266	nuclear receptor subfamily 3 group C member 2	Homo sapiens	192-231
31972205-0	2020	Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells.	Corticosterone	39-53	pro-opiomelanocortin-alpha	Mus musculus	26-30
31972205-4	2020	MAIN METHODS: Y1 mouse adrenocortical cells were treated with ACTH for up to 60 min to establish a cell model of corticosterone secretion.	Corticosterone	113-127	pro-opiomelanocortin-alpha	Mus musculus	62-66
31972205-6	2020	RESULTS: We demonstrated that GSE inhibits ACTH-stimulated corticosterone production in Y1 cells by inhibiting factors critical for steroid synthesis.	Corticosterone	59-73	pro-opiomelanocortin-alpha	Mus musculus	43-47
31972205-7	2020	Ginsenoside Rd, an active ingredient of GSE, inhibits corticosterone secretion in the cells and impedes ACTH-induced corticosterone biosynthesis through down-regulation of proteins in the cAMP/PKA/CREB signaling pathway.	Corticosterone	117-131	pro-opiomelanocortin-alpha	Mus musculus	104-108
31972205-9	2020	CONCLUSION: Our findings indicate that ginsenoside Rd inhibits ACTH-induced corticosterone production through blockading the MC2R-cAMP/PKA/CREB pathway in adrenocortical cells.	Corticosterone	76-90	pro-opiomelanocortin-alpha	Mus musculus	63-67
31972205-9	2020	CONCLUSION: Our findings indicate that ginsenoside Rd inhibits ACTH-induced corticosterone production through blockading the MC2R-cAMP/PKA/CREB pathway in adrenocortical cells.	Corticosterone	76-90	melanocortin 2 receptor	Mus musculus	125-129
31972205-9	2020	CONCLUSION: Our findings indicate that ginsenoside Rd inhibits ACTH-induced corticosterone production through blockading the MC2R-cAMP/PKA/CREB pathway in adrenocortical cells.	Corticosterone	76-90	cAMP responsive element binding protein 1	Mus musculus	139-143
32231512-0	2020	Corticosterone Treatment and Incubation Time After Contextual Fear Conditioning Synergistically Induce Fear Memory Generalization in Neuropeptide S Receptor-Deficient Mice.	Corticosterone	0-14	neuropeptide S receptor 1	Mus musculus	133-156
31234698-3	2020	We generated NSC-specific, inducible Atg7 conditional knockout mice and found that they had an intact number of NSCs and neurogenesis level under chronic restraint stress and were resilient to stress- or corticosterone-induced cognitive and mood deficits.	Corticosterone	204-218	autophagy related 7	Mus musculus	37-41
31234698-4	2020	Corticosterone treatment of adult hippocampal NSC cultures induced ACD via SGK3 (serum/glucocorticoid regulated kinase 3) without signs of apoptosis.	Corticosterone	0-14	serum/glucocorticoid regulated kinase 3	Mus musculus	75-79
31234698-4	2020	Corticosterone treatment of adult hippocampal NSC cultures induced ACD via SGK3 (serum/glucocorticoid regulated kinase 3) without signs of apoptosis.	Corticosterone	0-14	serum/glucocorticoid regulated kinase 3	Mus musculus	81-120
31748785-3	2020	Here we sought to determine if corticosterone induced metabolic and behavioral changes require functional ghrelin receptors (GHSR).	Corticosterone	31-45	ghrelin	Mus musculus	106-113
31748785-3	2020	Here we sought to determine if corticosterone induced metabolic and behavioral changes require functional ghrelin receptors (GHSR).	Corticosterone	31-45	growth hormone secretagogue receptor	Mus musculus	125-129
31748785-4	2020	To do this, we treated male C57BL mice with chronic corticosterone (CORT) mixed in their drinking water for 28 days.	Corticosterone	52-66	cortistatin	Mus musculus	68-72
31885208-6	2020	A two-way cluster analysis revealed that two major clusters of factors were associated with the responses seen: (a) mRNA levels of GCR and heat-shock proteins in both blood cells were associated with plasma corticosterone concentration, whereas (b) androgen receptors and JUN mRNA levels in both blood cells were associated with cloacal temperature and body composition.	Corticosterone	207-221	glucocorticoid receptor	Alligator mississippiensis	131-134
31950150-6	2020	Plasma corticosterone levels in bAdx mice implanted with SF-1/Ad4BP-induced steroidogenic cells and control ADSCs were 5.41 +- 2.26 ng/mL (mean +- SEM) and undetectable at 7 days after implantation, respectively.	Corticosterone	7-21	nuclear receptor subfamily 5, group A, member 1	Mus musculus	57-61
31950150-6	2020	Plasma corticosterone levels in bAdx mice implanted with SF-1/Ad4BP-induced steroidogenic cells and control ADSCs were 5.41 +- 2.26 ng/mL (mean +- SEM) and undetectable at 7 days after implantation, respectively.	Corticosterone	7-21	nuclear receptor subfamily 5, group A, member 1	Mus musculus	62-67
32133707-3	2020	Previously, we have shown that, following s.c. injection of 2.0 mol L-1 NaCl, oxytocin synthesising neurones are activated in the rat PVN, an oxytocin receptor (Oxtr)-dependent inhibitory tone develops on a subset of parvocellular neurones and stress-mediated increases in plasma corticosterone levels are blunted.	Corticosterone	280-294	oxytocin receptor	Rattus norvegicus	142-159
32133707-3	2020	Previously, we have shown that, following s.c. injection of 2.0 mol L-1 NaCl, oxytocin synthesising neurones are activated in the rat PVN, an oxytocin receptor (Oxtr)-dependent inhibitory tone develops on a subset of parvocellular neurones and stress-mediated increases in plasma corticosterone levels are blunted.	Corticosterone	280-294	oxytocin receptor	Rattus norvegicus	161-165
31818774-3	2020	METHODS: Mice were subcutaneously injected with corticosterone (CORT; 20 mg/kg) each day for 6 weeks, while another group was given an additional dose of NMN (300 mg/kg) by oral gavage in the last 2 weeks.	Corticosterone	48-62	cortistatin	Mus musculus	64-68
31955266-7	2020	The AGE-BSA-mediated suppression of noradrenaline-induced contraction was prevented by the organic cation transporter 3 (OCT3) inhibitor corticosterone, whereas the expression of OCT3 protein was similar between control and AGE-BSA-treated endothelium-denuded carotid arteries.	Corticosterone	137-151	solute carrier family 22 member 3	Rattus norvegicus	91-119
31955266-7	2020	The AGE-BSA-mediated suppression of noradrenaline-induced contraction was prevented by the organic cation transporter 3 (OCT3) inhibitor corticosterone, whereas the expression of OCT3 protein was similar between control and AGE-BSA-treated endothelium-denuded carotid arteries.	Corticosterone	137-151	solute carrier family 22 member 3	Rattus norvegicus	121-125
31937523-3	2020	Using real-time FRET to measure JNK activity, we find that either excitotoxic insult (NMDA) or endocrine stress (corticosterone), activate spine-head JNK causing internalization of AMPARs and spine retraction.	Corticosterone	113-127	mitogen-activated protein kinase 8	Rattus norvegicus	32-35
31937523-3	2020	Using real-time FRET to measure JNK activity, we find that either excitotoxic insult (NMDA) or endocrine stress (corticosterone), activate spine-head JNK causing internalization of AMPARs and spine retraction.	Corticosterone	113-127	mitogen-activated protein kinase 8	Rattus norvegicus	150-153
31937523-6	2020	In conclusion, we show that JNK activation plays a role in triggering spine elimination by NMDA or corticosterone stress, whereas inhibition of JNK facilitates regrowth of spines even in the continued presence of glucocorticoid.	Corticosterone	99-113	mitogen-activated protein kinase 8	Rattus norvegicus	28-31
31937523-10	2020	Light-activation of the JNK inhibitor reduces AMPA receptor removal and spine regression in response to corticosterone and NMDA stress.	Corticosterone	104-118	mitogen-activated protein kinase 8	Rattus norvegicus	24-27
32080229-6	2020	Finally, IL-1beta antagonism showed a tendency for reduced plasma corticosterone concentrations, possibly explaining the metabolic improvement.	Corticosterone	66-80	interleukin 1 alpha	Mus musculus	9-17
31423743-0	2020	Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling.	Corticosterone	0-14	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	93-97
32024104-0	2020	Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation.	Corticosterone	128-142	C-C motif chemokine receptor 5	Rattus norvegicus	12-16
32024104-0	2020	Hippocampal CCR5/RANTES Elevations in a Rodent Model of Post-Traumatic Stress Disorder: Maraviroc (a CCR5 Antagonist) Increases Corticosterone Levels and Enhances Fear Memory Consolidation.	Corticosterone	128-142	C-C motif chemokine receptor 5	Rattus norvegicus	101-105
31423743-0	2020	Corticosterone induces neurotoxicity in PC12 cells via disrupting autophagy flux mediated by AMPK/mTOR signaling.	Corticosterone	0-14	mechanistic target of rapamycin kinase	Rattus norvegicus	98-102
32038643-5	2019	Continuous oral administration of corticosterone (CORT) to pregnant mice throughout the second half of pregnancy resulted in an ~2-fold increase in circulating hormone in dams with no concomitant increase in fetal circulation, similar to the human condition.	Corticosterone	34-48	cortistatin	Mus musculus	50-54
31685528-7	2020	Furthermore, during hyperinsulinemic-hypoglycemic clamps, ghrelin-KO mice required a 10-fold higher glucose infusion rate (GIR) and exhibited less robust corticosterone and growth hormone responses.	Corticosterone	154-168	ghrelin	Mus musculus	58-65
32051875-9	2020	In mice under a high fat diet, TBP lowered blood glucose level and corticosterone production and improved total testosterone production after five weeks of treatment.	Corticosterone	67-81	TATA box binding protein	Mus musculus	31-34
31767736-1	2020	The glucocorticoid hormone corticosterone (CORT) has classically been used in ecophysiological studies as a proxy for stress and energy mobilization, but rarely are CORT and the energy metabolites themselves concurrently measured.	Corticosterone	27-41	cortistatin	Homo sapiens	43-47
31518662-2	2020	We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF+/-), but not in wildtype controls (WT) or females.	Corticosterone	72-86	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	232-236
31518662-2	2020	We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF+/-), but not in wildtype controls (WT) or females.	Corticosterone	72-86	brain derived neurotrophic factor	Mus musculus	251-255
31518662-2	2020	We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF+/-), but not in wildtype controls (WT) or females.	Corticosterone	72-86	brain derived neurotrophic factor	Mus musculus	275-279
31518662-2	2020	We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF+/-), but not in wildtype controls (WT) or females.	Corticosterone	88-92	glutamate receptor, ionotropic, NMDA2B (epsilon 2)	Mus musculus	232-236
31518662-2	2020	We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF+/-), but not in wildtype controls (WT) or females.	Corticosterone	88-92	brain derived neurotrophic factor	Mus musculus	251-255
31518662-2	2020	We have previously shown in mice that chronic adolescent treatment with corticosterone (CORT), to simulate stress, resulted in spatial memory deficits and markedly elevated levels of the N-methyl-D-aspartate (NMDA) receptor subunit NR2B in adult male BDNF heterozygous mice (BDNF+/-), but not in wildtype controls (WT) or females.	Corticosterone	88-92	brain derived neurotrophic factor	Mus musculus	275-279
31745845-0	2020	Chronic corticosterone exposure induces liver inflammation and fibrosis in association with m6A-linked post-transcriptional suppression of heat shock proteins in chicken.	Corticosterone	8-22	glycoprotein M6A	Gallus gallus	92-95
31184364-4	2020	Next, exposure of female rats to 21-day regimen of corticosterone resulted in a similar pattern of mPFC dendritic spine attrition and increase in spine volume.	Corticosterone	51-65	complement factor properdin	Mus musculus	99-103
31765157-10	2020	This results from the higher concentration of corticosterone in blood after nasal administration of CPN as compared to nasal application of saline.	Corticosterone	46-60	carboxypeptidase N, polypeptide 1	Mus musculus	100-103
32778039-0	2020	beta-1, 3-Glucan attenuated chronic unpredictable mild stress induced cognitive impairment in rodents via normalizing corticosterone levels.	Corticosterone	118-132	immunoglobulin kappa variable 2D-18 (pseudogene)	Homo sapiens	0-9
31914916-0	2020	The role of Annexin A1 and formyl peptide receptor 2/3 signaling on chronic corticosterone-induced depression-like behaviors and impairment in hippocampal-dependent memory.	Corticosterone	76-90	annexin A1	Mus musculus	12-22
31914916-3	2020	OBJECTIVE: The present study aimed to evaluate the potential role of ANXA1 and its main receptor, as a cellular mediator of behavioural disorders, in a model of corticosterone (CORT)-induced depression and subsequently the possible correlation between the depressive state and impairment of hippocampal memory.	Corticosterone	161-175	annexin A1	Mus musculus	69-74
31914916-3	2020	OBJECTIVE: The present study aimed to evaluate the potential role of ANXA1 and its main receptor, as a cellular mediator of behavioural disorders, in a model of corticosterone (CORT)-induced depression and subsequently the possible correlation between the depressive state and impairment of hippocampal memory.	Corticosterone	161-175	cortistatin	Mus musculus	177-181
33440383-7	2020	The chronic elevation of the corticosterone levels was accompanied by a progressive deficit of the GR expression in the liver, increased hepatic glycogen content, dysregulated glucose-6-phosphatase activity, and eventually hypoglycemia.	Corticosterone	29-43	glutathione-disulfide reductase	Rattus norvegicus	99-101
33440383-7	2020	The chronic elevation of the corticosterone levels was accompanied by a progressive deficit of the GR expression in the liver, increased hepatic glycogen content, dysregulated glucose-6-phosphatase activity, and eventually hypoglycemia.	Corticosterone	29-43	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	176-197
33440383-8	2020	Elevated corticosterone appears to result from the impairment of the mechanisms of glucocorticoid negative feedback since a substantial decrease in both the total number of GR and their nuclear localization was observed already in the hippocampus of newborn rat pups and persisted throughout life.	Corticosterone	9-23	glutathione-disulfide reductase	Rattus norvegicus	173-175
31745845-3	2020	However, changes of HSPs and the m6A methylation on their mRNAs in response to chronic CORT treatment in chicken liver have not been reported.	Corticosterone	87-91	glycoprotein M6A	Gallus gallus	33-36
31745845-6	2020	The m6A-seq analysis revealed 2-6 significantly (P &lt; 0.05) hypermethylated m6A peaks in the mRNA of 4 different species of HSPs in CORT-treated chicken liver.	Corticosterone	134-138	glycoprotein M6A	Gallus gallus	4-7
31745845-6	2020	The m6A-seq analysis revealed 2-6 significantly (P &lt; 0.05) hypermethylated m6A peaks in the mRNA of 4 different species of HSPs in CORT-treated chicken liver.	Corticosterone	134-138	glycoprotein M6A	Gallus gallus	78-81
31745845-9	2020	In conclusion, chronic CORT exposure induces inflammation and fibrosis in chicken liver along with an increase in the levels and m6A methylation of several HSPs mRNAs; HSPs levels were however reduced under the indicated conditions.	Corticosterone	23-27	glycoprotein M6A	Gallus gallus	129-132
31745845-10	2020	Results presented suggest that the reduction in HSPs levels may be associated with m6A methylation in CORT-exposed chickens.	Corticosterone	102-106	glycoprotein M6A	Gallus gallus	83-86
31563645-10	2020	Combining all individuals from the nine populations, we found that individual variation in alpha-MSH was not associated with individual variation in melanization, but levels of alpha-MSH were positively associated with plasma testosterone and negatively associated with corticosterone.	Corticosterone	270-284	alpha-msh	Anolis carolinensis	177-186
32001956-8	2020	High plasma corticosterone levels in diabetes may affect transcriptional regulation to promote increases in Cyp24a1 expression.	Corticosterone	12-26	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	108-115
31600723-0	2020	Progesterone-regulated Hsd11b2 as a barrier to balance mouse uterine corticosterone.	Corticosterone	69-83	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	23-30
31600723-10	2020	The uterine level of Corticosterone (Cort) is regulated by Hsd11b2 during preimplantation.	Corticosterone	21-35	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	59-66
31600723-10	2020	The uterine level of Corticosterone (Cort) is regulated by Hsd11b2 during preimplantation.	Corticosterone	21-25	hydroxysteroid 11-beta dehydrogenase 2	Mus musculus	59-66
31756168-7	2020	However, under 60% food restriction, AgRP STAT5-knockout mice had a blunted upregulation of hypothalamic Agrp mRNA expression and corticosterone serum levels compared to control mice, suggesting a possible role for STAT5 in AgRP neurons for neuroendocrine adaptations to food restriction.	Corticosterone	130-144	agouti related neuropeptide	Mus musculus	37-41
31756168-7	2020	However, under 60% food restriction, AgRP STAT5-knockout mice had a blunted upregulation of hypothalamic Agrp mRNA expression and corticosterone serum levels compared to control mice, suggesting a possible role for STAT5 in AgRP neurons for neuroendocrine adaptations to food restriction.	Corticosterone	130-144	signal transducer and activator of transcription 5A	Mus musculus	42-47
31715030-7	2020	The effects of co-application of corticosterone and isoproterenol on spines could be prevented by blocking the glucocorticoid receptor (GR)-antagonist RU486.	Corticosterone	33-47	nuclear receptor subfamily 3 group C member 1	Homo sapiens	111-134
31715030-7	2020	The effects of co-application of corticosterone and isoproterenol on spines could be prevented by blocking the glucocorticoid receptor (GR)-antagonist RU486.	Corticosterone	33-47	nuclear receptor subfamily 3 group C member 1	Homo sapiens	136-138
31461711-0	2020	Estradiol enables chronic corticosterone to inhibit pulsatile LH secretion and suppress Kiss1 neuronal activation in female mice.	Corticosterone	26-40	KiSS-1 metastasis-suppressor	Mus musculus	88-93
31461711-8	2020	We show that the majority of arcuate Kiss1 neurons contain glucocorticoid receptor, revealing a potential site of corticosterone action.	Corticosterone	114-128	KiSS-1 metastasis-suppressor	Mus musculus	37-42
31461711-9	2020	Although arcuate Kiss1 and Tac2 gene expression did not change in response to corticosterone, arcuate Kiss1 neuronal activation was significantly reduced by chronic corticosterone, but only in mice treated with estradiol.	Corticosterone	165-179	KiSS-1 metastasis-suppressor	Mus musculus	102-107
31461711-10	2020	CONCLUSIONS: Collectively, these data demonstrate that chronic corticosterone inhibits LH pulse frequency and reduces Kiss1 neuronal activation in female mice, both in an estradiol-dependent manner.	Corticosterone	63-77	KiSS-1 metastasis-suppressor	Mus musculus	118-123
32348866-0	2020	Combined neurodevelopmental exposure to deltamethrin and corticosterone is associated with Nr3c1 hypermethylation in the midbrain of male mice.	Corticosterone	57-71	nuclear receptor subfamily 3, group C, member 1	Mus musculus	91-96
32348866-4	2020	Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development.	Corticosterone	239-253	nuclear receptor subfamily 3, group C, member 1	Mus musculus	131-154
32348866-4	2020	Through targeted next-generation sequencing of a panel of cortisol and dopamine pathway genes, we observed hypermethylation of the glucocorticoid receptor gene, Nr3c1, in the midbrain of C57/BL6N males in response to dual deltamethrin and corticosterone exposures during development.	Corticosterone	239-253	nuclear receptor subfamily 3, group C, member 1	Mus musculus	161-166
32348866-5	2020	This is the first description of DNA methylation studies of Nr3c1 and key dopaminergic genes within the midbrain in response to a pyrethroid insecticide, corticosterone, and these two exposures together.	Corticosterone	154-168	nuclear receptor subfamily 3, group C, member 1	Mus musculus	60-65
31765739-8	2020	In vitro, the expression levels of IGF1 and GLUT1 were inhibited by corticosterone but remained unchanged under caffeine treatment.	Corticosterone	68-82	insulin-like growth factor 1	Rattus norvegicus	35-39
31557761-6	2020	Clock gene expression in the cerebellum was abolished in rats with a lesioned SCN, but exogenous corticosterone restored the daily rhythm in clock gene expression in the cerebellar cortex, as revealed by quantitative real-time PCR and radiochemical in situ hybridization for detection of the core clock genes Per1, Per2 and Arntl.	Corticosterone	97-111	period circadian regulator 2	Rattus norvegicus	315-319
31557761-6	2020	Clock gene expression in the cerebellum was abolished in rats with a lesioned SCN, but exogenous corticosterone restored the daily rhythm in clock gene expression in the cerebellar cortex, as revealed by quantitative real-time PCR and radiochemical in situ hybridization for detection of the core clock genes Per1, Per2 and Arntl.	Corticosterone	97-111	aryl hydrocarbon receptor nuclear translocator-like	Rattus norvegicus	324-329
31557761-8	2020	RNAscope in situ hybridization further revealed that the glucocorticoid receptor colocalizes with clock gene products in cells of the cerebellar cortex, suggesting that corticosterone exerts its actions by binding directly to receptors in neurons of the cerebellum.	Corticosterone	169-183	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	57-80
31765739-8	2020	In vitro, the expression levels of IGF1 and GLUT1 were inhibited by corticosterone but remained unchanged under caffeine treatment.	Corticosterone	68-82	solute carrier family 2 member 1	Rattus norvegicus	44-49
31765739-9	2020	Exogenous IGF1 can reverse the corticosterone-induced decrease in GLUT1 expression and promote AGEs production, while mifepristone (a glucocorticoid receptor inhibitor) reversed the corticosterone-induced low expression of IGF1 and GLUT1.	Corticosterone	31-45	insulin-like growth factor 1	Rattus norvegicus	10-14
31765739-9	2020	Exogenous IGF1 can reverse the corticosterone-induced decrease in GLUT1 expression and promote AGEs production, while mifepristone (a glucocorticoid receptor inhibitor) reversed the corticosterone-induced low expression of IGF1 and GLUT1.	Corticosterone	31-45	solute carrier family 2 member 1	Rattus norvegicus	66-71
31765739-9	2020	Exogenous IGF1 can reverse the corticosterone-induced decrease in GLUT1 expression and promote AGEs production, while mifepristone (a glucocorticoid receptor inhibitor) reversed the corticosterone-induced low expression of IGF1 and GLUT1.	Corticosterone	31-45	insulin-like growth factor 1	Rattus norvegicus	223-227
31765739-9	2020	Exogenous IGF1 can reverse the corticosterone-induced decrease in GLUT1 expression and promote AGEs production, while mifepristone (a glucocorticoid receptor inhibitor) reversed the corticosterone-induced low expression of IGF1 and GLUT1.	Corticosterone	31-45	solute carrier family 2 member 1	Rattus norvegicus	232-237
31765739-9	2020	Exogenous IGF1 can reverse the corticosterone-induced decrease in GLUT1 expression and promote AGEs production, while mifepristone (a glucocorticoid receptor inhibitor) reversed the corticosterone-induced low expression of IGF1 and GLUT1.	Corticosterone	182-196	insulin-like growth factor 1	Rattus norvegicus	10-14
31765739-9	2020	Exogenous IGF1 can reverse the corticosterone-induced decrease in GLUT1 expression and promote AGEs production, while mifepristone (a glucocorticoid receptor inhibitor) reversed the corticosterone-induced low expression of IGF1 and GLUT1.	Corticosterone	182-196	insulin-like growth factor 1	Rattus norvegicus	223-227
31765739-9	2020	Exogenous IGF1 can reverse the corticosterone-induced decrease in GLUT1 expression and promote AGEs production, while mifepristone (a glucocorticoid receptor inhibitor) reversed the corticosterone-induced low expression of IGF1 and GLUT1.	Corticosterone	182-196	solute carrier family 2 member 1	Rattus norvegicus	232-237
31187686-2	2020	The Morris water maze task probes spatial learning and memory in rodents and glucocorticoids (i.e. corticosterone (CORT) in rats) have been suggested to elicit a facilitating action on memory formation.	Corticosterone	99-113	cortistatin	Rattus norvegicus	115-119
31912697-0	2019	Contrasting effects of acute and long-term corticosterone treatment on amyloid-beta, beta-secretase 1 expression, and nuclear factor kappa B nuclear translocation.	Corticosterone	43-57	beta-secretase 1	Rattus norvegicus	85-101
32138948-6	2020	Co-administration of AVT and CRH peripherally, resulted in a synergistic stimulation of corticosterone release.	Corticosterone	88-102	corticotropin releasing hormone	Gallus gallus	29-32
31888678-1	2019	Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity.	Corticosterone	8-22	cortistatin	Mus musculus	24-28
31888678-1	2019	Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity.	Corticosterone	8-22	nuclear receptor subfamily 3, group C, member 1	Mus musculus	115-138
31888678-1	2019	Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity.	Corticosterone	8-22	nuclear receptor subfamily 3, group C, member 1	Mus musculus	140-142
31888678-1	2019	Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity.	Corticosterone	8-22	brain derived neurotrophic factor	Mus musculus	145-178
31888678-1	2019	Chronic corticosterone (CORT) stress is an anxiety and depression inducing factor that involves the dysfunction of glucocorticoid receptor (GR), brain-derived neurotrophic factor (BDNF), and neuronal plasticity.	Corticosterone	8-22	brain derived neurotrophic factor	Mus musculus	180-184
31912697-4	2019	We demonstrate that corticosterone can both positively and negatively regulate amyloid-beta expression, which may be related to the ratio of neuroinflammation regulator and Beta-secretase 1 signaling in rat primary cortical neurons.	Corticosterone	20-34	beta-secretase 1	Rattus norvegicus	173-189
31912697-6	2019	In contrast, 1 microM corticosterone treatment over 3 days increased nuclear neuroinflammation regulator localization (P < 0.001), followed by the upregulation of Beta-secretase 1 (P < 0.01) and amyloid-beta1-42 (P < 0.05) expression.	Corticosterone	22-36	beta-secretase 1	Rattus norvegicus	163-179
31912697-7	2019	This work is the first to demonstrate that the duration of corticosterone exposure can promote or inhibit amyloid-beta production, and to link this effect with Beta-secretase 1 / neuroinflammation regulator signaling, together with providing valuable insight into the mechanisms of neuroinflammation and neuroprotection.	Corticosterone	59-73	beta-secretase 1	Rattus norvegicus	160-176
31848364-3	2019	Corticosterone administration to birds differentially regulated lipogenesis genes (i.e. FAS, ACC, ME, and SREBF1), and histopathological examination indicated lipid deposition in hepatocytes.	Corticosterone	0-14	sterol regulatory element binding transcription factor 1	Gallus gallus	106-112
31848364-6	2019	Furthermore, CORT administration caused lymphoid depletion in the bursa of Fabricius and elevated IL6 and TGFbeta2 mRNA expression after 5 and 12 days of CORT administration.	Corticosterone	13-17	interleukin 6	Gallus gallus	98-101
31848364-6	2019	Furthermore, CORT administration caused lymphoid depletion in the bursa of Fabricius and elevated IL6 and TGFbeta2 mRNA expression after 5 and 12 days of CORT administration.	Corticosterone	13-17	transforming growth factor beta 2	Gallus gallus	106-114
31848364-6	2019	Furthermore, CORT administration caused lymphoid depletion in the bursa of Fabricius and elevated IL6 and TGFbeta2 mRNA expression after 5 and 12 days of CORT administration.	Corticosterone	154-158	interleukin 6	Gallus gallus	98-101
31848364-6	2019	Furthermore, CORT administration caused lymphoid depletion in the bursa of Fabricius and elevated IL6 and TGFbeta2 mRNA expression after 5 and 12 days of CORT administration.	Corticosterone	154-158	transforming growth factor beta 2	Gallus gallus	106-114
31848393-6	2019	Paradoxically, these Fgf21-/- CKD mice escaped several complications observed in wild-type mice, including augmentation of blood pressure elevating response and activation of the sympathetic nervous system during physical activity and increase in serum noradrenalin and corticosterone levels.	Corticosterone	270-284	fibroblast growth factor 21	Mus musculus	21-26
31824675-2	2019	The glucocorticoid hormones, such as corticosterone (CORT), facilitate coping with such stressors, but these hormones can have quite distinct effects contingent on the duration of their elevation.	Corticosterone	37-51	cortistatin	Homo sapiens	53-57
31588796-6	2019	Corticosterone also increased the whole kidney expression of canonical clock genes: period circadian protein homolog 1 (Per1), Per2, cryptochrome 1, and aryl hydrocarbon receptor nuclear translocator-like protein 1.	Corticosterone	0-14	period circadian clock 1	Mus musculus	84-118
31822658-6	2019	We found that CORT induced avoidance in the open field and NSF.	Corticosterone	14-18	N-ethylmaleimide sensitive fusion protein	Mus musculus	59-62
31588796-6	2019	Corticosterone also increased the whole kidney expression of canonical clock genes: period circadian protein homolog 1 (Per1), Per2, cryptochrome 1, and aryl hydrocarbon receptor nuclear translocator-like protein 1.	Corticosterone	0-14	period circadian clock 2	Mus musculus	127-131
31588796-6	2019	Corticosterone also increased the whole kidney expression of canonical clock genes: period circadian protein homolog 1 (Per1), Per2, cryptochrome 1, and aryl hydrocarbon receptor nuclear translocator-like protein 1.	Corticosterone	0-14	cryptochrome 1 (photolyase-like)	Mus musculus	133-147
31588796-6	2019	Corticosterone also increased the whole kidney expression of canonical clock genes: period circadian protein homolog 1 (Per1), Per2, cryptochrome 1, and aryl hydrocarbon receptor nuclear translocator-like protein 1.	Corticosterone	0-14	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	153-214
31588796-7	2019	In adrenal-intact mice, chronic blockade of glucocorticoid receptor (GR) with RU486 did not change total NCC but prevented corticosterone-induced NCC phosphorylation and activation of clock genes.	Corticosterone	123-137	nuclear receptor subfamily 3, group C, member 1	Mus musculus	44-67
31588796-7	2019	In adrenal-intact mice, chronic blockade of glucocorticoid receptor (GR) with RU486 did not change total NCC but prevented corticosterone-induced NCC phosphorylation and activation of clock genes.	Corticosterone	123-137	nuclear receptor subfamily 3, group C, member 1	Mus musculus	69-71
31857811-3	2019	We tested the hypothesis that Eastern Fence Lizards cope with fire disturbance effects by modulating their secretion of corticosterone (CORT).	Corticosterone	120-134	cortistatin	Homo sapiens	136-140
31812985-12	2019	CONCLUSIONS: These results suggest that naturally derived polyphenols protect cortical cells against corticosterone-induced cytotoxicity and enhance cell survival via modulation of the Nrf2 pathway and expression of Fkbp5.	Corticosterone	101-115	FKBP prolyl isomerase 5	Homo sapiens	216-221
31175878-8	2019	Traumatized MeCP2-308 mice also displayed abnormal post-traumatic plasma levels of the stress hormone corticosterone and altered peripheral gene expression mirroring that of PTSD patients.	Corticosterone	102-116	methyl CpG binding protein 2	Mus musculus	12-17
31812985-9	2019	Basal levels of Bdnf mRNA were also decreased after corticosterone insult; however, this was reversed by both polyphenol treatments.	Corticosterone	52-66	brain derived neurotrophic factor	Homo sapiens	16-20
31608449-0	2019	Thymol reverses depression-like behaviour and upregulates hippocampal BDNF levels in chronic corticosterone-induced depression model in female mice.	Corticosterone	93-107	brain derived neurotrophic factor	Mus musculus	70-74
31614158-8	2019	Additionally, the oral administration of crocin-I at a dose of 40 mg/kg reduced the CORT-induced accumulation of nicotinamide in the liver of the mice to improve the synthesis of NAD+, thereby stimulating the activity of SIRT3 deacetylase to elevate the activity of antioxidants such as superoxide dismutase 2 and glutathione reductase.	Corticosterone	84-88	glutathione reductase	Mus musculus	314-335
31586460-7	2019	Our result showed that chronic treatment with stress hormone corticosterone increased Txnip protein levels and Txnip-NLRP3 binding in N9 mouse microglia, in primary cultured mouse microglia and in mouse brain.	Corticosterone	61-75	thioredoxin interacting protein	Mus musculus	86-91
31586460-7	2019	Our result showed that chronic treatment with stress hormone corticosterone increased Txnip protein levels and Txnip-NLRP3 binding in N9 mouse microglia, in primary cultured mouse microglia and in mouse brain.	Corticosterone	61-75	thioredoxin interacting protein	Mus musculus	111-116
31586460-7	2019	Our result showed that chronic treatment with stress hormone corticosterone increased Txnip protein levels and Txnip-NLRP3 binding in N9 mouse microglia, in primary cultured mouse microglia and in mouse brain.	Corticosterone	61-75	NLR family, pyrin domain containing 3	Mus musculus	117-122
31586460-8	2019	Our result also showed that chronic corticosterone treatment increased procaspase-1 cleavage, caspase-1 activity and interleukin-1beta release in N9 microglia.	Corticosterone	36-50	caspase 1	Mus musculus	74-83
31586460-8	2019	Our result also showed that chronic corticosterone treatment increased procaspase-1 cleavage, caspase-1 activity and interleukin-1beta release in N9 microglia.	Corticosterone	36-50	interleukin 1 beta	Mus musculus	117-134
31586460-9	2019	Using CRISPR/Cas9 method we found that knocking out Txnip inhibited corticosterone-increased caspase-1 activity and interleukin-1beta release.	Corticosterone	68-82	thioredoxin interacting protein	Mus musculus	52-57
31586460-9	2019	Using CRISPR/Cas9 method we found that knocking out Txnip inhibited corticosterone-increased caspase-1 activity and interleukin-1beta release.	Corticosterone	68-82	caspase 1	Mus musculus	93-102
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	thioredoxin interacting protein	Mus musculus	70-75
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	thioredoxin interacting protein	Mus musculus	90-95
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	NLR family, pyrin domain containing 3	Mus musculus	96-101
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	NLR family, pyrin domain containing 3	Mus musculus	127-132
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	caspase 1	Mus musculus	174-183
31586460-10	2019	Our results suggest that chronic corticosterone treatment upregulates Txnip and increases Txnip-NLRP3 binding, which activates NLRP3 inflammasome, resulting in activation of caspase-1 and in further releasing of interleukin-1beta.	Corticosterone	33-47	interleukin 1 beta	Mus musculus	212-229
31586460-11	2019	It is therefore likely that Txnip-activated NLRP3 inflammasome contributes to corticosterone-caused neuroinflammation.	Corticosterone	78-92	thioredoxin interacting protein	Mus musculus	28-33
31586460-11	2019	It is therefore likely that Txnip-activated NLRP3 inflammasome contributes to corticosterone-caused neuroinflammation.	Corticosterone	78-92	NLR family, pyrin domain containing 3	Mus musculus	44-49
31756901-11	2019	Our study indicates that G. japonicum extract exhibits antidepressant-like activity in CORT-induced depressive mice, which might be as a result of increased BDNF expression.	Corticosterone	87-91	brain derived neurotrophic factor	Mus musculus	157-161
31526526-3	2019	In mice, exposure to elevated levels of the primary stress hormone, corticosterone (CORT), during early adolescence is sufficient to impair response-outcome decision making later in life, biasing response strategies towards inflexible habits.	Corticosterone	68-82	cortistatin	Mus musculus	84-88
31541913-5	2019	We then analyzed the corticosterone (CORT) response to an inflammatory stimulus, as a measure of the hypothalamus-pituitary-adrenal (HPA) function, and the neuroinflammatory state in adult and young animals.	Corticosterone	21-35	cortistatin	Mus musculus	37-41
31827786-1	2019	Background: Laying hens supplemented with betaine demonstrate activated adrenal steroidogenesis and deposit higher corticosterone (CORT) in the egg yolk.	Corticosterone	115-129	CORT	Gallus gallus	131-135
31713091-9	2019	These results indicate that the protective effect of UA against the cytotoxicity induced by corticosterone in HT22 cells may involve PKA, PKC, CaMKII, and ERK1/2 activation.	Corticosterone	92-106	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	143-149
31713091-9	2019	These results indicate that the protective effect of UA against the cytotoxicity induced by corticosterone in HT22 cells may involve PKA, PKC, CaMKII, and ERK1/2 activation.	Corticosterone	92-106	mitogen-activated protein kinase 3	Mus musculus	155-161
31449812-6	2019	Additionally, the predicted rise in plasma corticosterone in response to OTR-A treatment was blunted in SS rats.	Corticosterone	43-57	oxytocin receptor	Rattus norvegicus	73-76
31090904-7	2019	The GR was activated with comparable potency to cortisol by corticosterone and 21-deoxycortisol or with 4-100x lower potency by 11-hydroxyprogesterone, 11-deoxycortisol, aldosterone, 11-deoxycorticosterone, progesterone, and 17-hydroxyprogesterone.	Corticosterone	60-74	nuclear receptor subfamily 3 group C member 1	Homo sapiens	4-6
31585362-0	2019	Chronic corticosterone aggravates behavioral and neuronal symptomatology in a mouse model of alpha-synuclein pathology.	Corticosterone	8-22	synuclein, alpha	Mus musculus	93-108
31585362-6	2019	Elevated corticosterone, however, reversed alpha-synuclein pathology-induced behavioral adaptations and was associated with increased dopaminergic cell loss as well as aggravated alpha-synuclein pathology in specific brain regions, such as the entorhinal cortex.	Corticosterone	9-23	synuclein, alpha	Mus musculus	43-58
31585362-6	2019	Elevated corticosterone, however, reversed alpha-synuclein pathology-induced behavioral adaptations and was associated with increased dopaminergic cell loss as well as aggravated alpha-synuclein pathology in specific brain regions, such as the entorhinal cortex.	Corticosterone	9-23	synuclein, alpha	Mus musculus	179-194
31782271-4	2019	Effects of inhibitors of the plasma membrane monoamine transporter (PMAT) and the organic cation transporter 3 (OCT3) (decynium-22 and corticosterone) on the 5-HT and 5-HIAA concentrations during baseline, coronary occlusion, and reperfusion were investigated.	Corticosterone	135-149	solute carrier family 22 member 3	Rattus norvegicus	112-116
31676805-0	2019	Developmental conditions modulate DNA methylation at the glucocorticoid receptor gene with cascading effects on expression and corticosterone levels in zebra finches.	Corticosterone	127-141	nuclear receptor subfamily 3 group C member 1	Homo sapiens	57-80
31676805-6	2019	Nr3c1 expression also correlated with glucocorticoid traits: higher expression level was associated with lower plasma baseline corticosterone concentrations and enhanced corticosterone reactivity.	Corticosterone	127-141	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-5
31676805-6	2019	Nr3c1 expression also correlated with glucocorticoid traits: higher expression level was associated with lower plasma baseline corticosterone concentrations and enhanced corticosterone reactivity.	Corticosterone	170-184	nuclear receptor subfamily 3 group C member 1	Homo sapiens	0-5
31736706-6	2019	Key elements though in the adrenal gland involved in corticosterone and aldosterone synthesis were altered in particular with the Cyp11b2 gene downregulated in vivo and ex vivo.	Corticosterone	53-67	cytochrome P450 family 11 subfamily B member 2	Homo sapiens	130-137
31587552-10	2019	OXT 10 mug or 20 mug significantly reduced CRF mRNA expression and the corticosterone concentration, OXT 20 mug also helped to restore GI motor dysfunction induced by CCS.	Corticosterone	71-85	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	0-3
31306741-6	2019	In vitro, corticosterone increased GR and HDAC7 whereas reduced the H3K9ac level of KLF4 and KLF4/Nephrin expression.	Corticosterone	10-24	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	35-37
31306741-6	2019	In vitro, corticosterone increased GR and HDAC7 whereas reduced the H3K9ac level of KLF4 and KLF4/Nephrin expression.	Corticosterone	10-24	histone deacetylase 7	Rattus norvegicus	42-47
31306741-6	2019	In vitro, corticosterone increased GR and HDAC7 whereas reduced the H3K9ac level of KLF4 and KLF4/Nephrin expression.	Corticosterone	10-24	Kruppel like factor 4	Rattus norvegicus	84-88
31306741-6	2019	In vitro, corticosterone increased GR and HDAC7 whereas reduced the H3K9ac level of KLF4 and KLF4/Nephrin expression.	Corticosterone	10-24	Kruppel like factor 4	Rattus norvegicus	93-97
31306741-6	2019	In vitro, corticosterone increased GR and HDAC7 whereas reduced the H3K9ac level of KLF4 and KLF4/Nephrin expression.	Corticosterone	10-24	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	98-105
31306741-7	2019	KLF4 over-expression reversed the reduction of Nephrin expression, knockdown of HDAC7 and GR antagonist RU486 partially reversed the inhibitory effects of corticosterone on H3K9ac level and KLF4 expression.	Corticosterone	155-169	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	47-54
31306741-7	2019	KLF4 over-expression reversed the reduction of Nephrin expression, knockdown of HDAC7 and GR antagonist RU486 partially reversed the inhibitory effects of corticosterone on H3K9ac level and KLF4 expression.	Corticosterone	155-169	histone deacetylase 7	Rattus norvegicus	80-85
31306741-7	2019	KLF4 over-expression reversed the reduction of Nephrin expression, knockdown of HDAC7 and GR antagonist RU486 partially reversed the inhibitory effects of corticosterone on H3K9ac level and KLF4 expression.	Corticosterone	155-169	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	90-92
31306741-7	2019	KLF4 over-expression reversed the reduction of Nephrin expression, knockdown of HDAC7 and GR antagonist RU486 partially reversed the inhibitory effects of corticosterone on H3K9ac level and KLF4 expression.	Corticosterone	155-169	Kruppel like factor 4	Rattus norvegicus	190-194
31306741-8	2019	In conclusion, PCE caused podocyte developmental toxicity in male offspring, which was associated with corticosterone-induced low-functional programming of KLF4 through GR/HDAC7/H3K9ac pathway.	Corticosterone	103-117	Kruppel like factor 4	Rattus norvegicus	156-160
31306741-8	2019	In conclusion, PCE caused podocyte developmental toxicity in male offspring, which was associated with corticosterone-induced low-functional programming of KLF4 through GR/HDAC7/H3K9ac pathway.	Corticosterone	103-117	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	169-171
31306741-8	2019	In conclusion, PCE caused podocyte developmental toxicity in male offspring, which was associated with corticosterone-induced low-functional programming of KLF4 through GR/HDAC7/H3K9ac pathway.	Corticosterone	103-117	histone deacetylase 7	Rattus norvegicus	172-177
31265057-6	2019	Corticosterone treatment increased adipose tissue mass in both sexes, which was reflected by elevated serum leptin levels.	Corticosterone	0-14	leptin	Mus musculus	108-114
31398249-6	2019	Maximal corticosterone responses to ACTH were elevated in cells from female KO mice without affecting the EC50 response.	Corticosterone	8-22	pro-opiomelanocortin-alpha	Mus musculus	36-40
31564078-1	2019	We isolated Lactobacillus mucosae NK41 and Bifidobacterium longum NK46 from human feces, which induced BDNF expression in corticosterone-stimulated SH-SY5Y cells, and examined their anti-depressive effects in mice.	Corticosterone	122-136	brain derived neurotrophic factor	Homo sapiens	103-107
31480771-4	2019	Adding the antiandrogen flutamide with the stress hormone corticosterone can additively decrease BDNF mRNA in mouse hippocampus mHippoE-14 cells, which can then be reversed via down-regulating the miR-204-5p expression.	Corticosterone	58-72	brain derived neurotrophic factor	Mus musculus	97-101
31570737-0	2019	Corticosteroid-Binding Globulin is expressed in the adrenal gland and its absence impairs corticosterone synthesis and secretion in a sex-dependent manner.	Corticosterone	90-104	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	0-31
31570737-4	2019	CBG-deficient mice show decreased total corticosterone levels with missing of classical sexual dimorphism, increased free corticosterone, higher adrenal gland size and altered HPA axis response to stress.	Corticosterone	40-54	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	0-3
31570737-4	2019	CBG-deficient mice show decreased total corticosterone levels with missing of classical sexual dimorphism, increased free corticosterone, higher adrenal gland size and altered HPA axis response to stress.	Corticosterone	122-136	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	0-3
31570737-8	2019	CBG-deficiency reduced the expression of ACTH receptor, SRB1 and the main genes involved in the adrenal hormones synthesis, stronger in females resulting in the loss of sexual dimorphism in corticosteroid adrenal synthesis, despite corticosterone content in adrenal glands from CBG-deficient females was similar to wildtype ones.	Corticosterone	232-246	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	0-3
31570737-9	2019	In conclusion, these results point to an unexplored and relevant role of CBG in the adrenal gland functionality related to corticosterone production and release.	Corticosterone	123-137	serine (or cysteine) peptidase inhibitor, clade A, member 6	Mus musculus	73-76
31579588-11	2019	At the cellular level, the inhibitor of FoxO1 as1842856 can also attenuate the lipid deposition of Hepa1-6 cells induced by corticosterone.	Corticosterone	124-138	forkhead box O1	Mus musculus	40-45
31540011-1	2019	Cold stress can induce autophagy mediated by excess corticosterone (CORT) in the hippocampus, but the internal mechanism induced by cold stress is not clear.	Corticosterone	52-66	cortistatin	Mus musculus	68-72
31500666-2	2019	The aim of the study was to explore the neuroprotective effect of CGA on corticosterone (CORT)-induced PC 12 cells and its mechanism, especially the autophagy pathway.	Corticosterone	73-87	cortistatin	Rattus norvegicus	89-93
31325084-8	2019	Microinjection of VIP also induced an increase in blood plasma glucose and corticosterone levels, and a reduction in free fatty acid plasma levels, but adrenalectomy abolished these effects.	Corticosterone	75-89	vasoactive intestinal peptide	Rattus norvegicus	18-21
30865372-7	2019	However, GFAP-TK rats, which lacked new neurons, continued to show elevated anxiety-like behavior and enhanced serum corticosterone response to anxiogenic experience.	Corticosterone	117-131	glial fibrillary acidic protein	Rattus norvegicus	9-13
31127538-0	2019	The Long-Term Effects of Ethanol and Corticosterone on the Mood-Related Behaviours and the Balance Between Mature BDNF and proBDNF in Mice.	Corticosterone	37-51	brain derived neurotrophic factor	Mus musculus	114-118
31127538-6	2019	Both proBDNF and mBDNF were significantly decreased in the corticosterone and ethanol groups compared with the control group in the prefrontal cortex, hippocampus, hypothalamus and adrenal.	Corticosterone	59-73	brain derived neurotrophic factor	Mus musculus	17-22
31127538-7	2019	The ratio of proBDNF/mBDNF in prefrontal cortex in the corticosterone group was increased compared with the ethanol group.	Corticosterone	55-69	brain derived neurotrophic factor	Mus musculus	21-26
31127538-9	2019	Ethanol and corticosterone downregulate both mBDNF and proBDNF and alter the balance of proBDNF/mBDNF in some tissues.	Corticosterone	12-26	brain derived neurotrophic factor	Mus musculus	45-50
31127538-9	2019	Ethanol and corticosterone downregulate both mBDNF and proBDNF and alter the balance of proBDNF/mBDNF in some tissues.	Corticosterone	12-26	brain derived neurotrophic factor	Mus musculus	96-101
31127538-10	2019	In conclusion, the ethanol and corticosterone may cause abnormal regulation of mBDNF and proBDNF which may lead to mood disorders.	Corticosterone	31-45	brain derived neurotrophic factor	Mus musculus	79-84
32118313-9	2020	SPR, perhaps, would have regulated the hypothalamo-pituitary-adrenal axis responsiveness as we observed a decrease in plasma corticosterone levels following SPR in VSL rats.	Corticosterone	125-139	sepiapterin reductase	Rattus norvegicus	0-3