PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 24205080-9 2013 Three potential compounds, methylprotodioscin, leonuride and catalpol, have been identified that bind to Cbl (RING) domain and interfere with the Cbl (RING)-UbCH7 protein-protein interaction. methyl protodioscin 27-45 Cbl proto-oncogene Homo sapiens 105-108 31870101-1 2019 BACKGROUND: Janus Tyrosine Kinase-2 (JAK2 V617F), a novel point mutation affecting the MPD"S is a somatic gain-of-function mutation. methyl protodioscin 87-90 Janus kinase 2 Homo sapiens 37-41 31870101-3 2019 AIM: To evaluate the prevalence and clinical significance of JAK2 V617F mutation in various MPD"s as well as in hematological malignancies. methyl protodioscin 92-95 Janus kinase 2 Homo sapiens 61-65 31870101-8 2019 JAK2-V617F was detected in 67/90 MPD patients and 02/17 for AML,01/11 for ALL-L1,02/12 for ALL-L2 and 02/07 for CML and 90 healthy controls. methyl protodioscin 33-36 Janus kinase 2 Homo sapiens 0-4 31870101-9 2019 CONCLUSION: From the above findings it is evident that the JAK2 V617F mutation is widespread not only in MPD"s but also in hematological malignancies, which might as well lead to the new classification of MPD"S. methyl protodioscin 105-108 Janus kinase 2 Homo sapiens 59-63 31870101-9 2019 CONCLUSION: From the above findings it is evident that the JAK2 V617F mutation is widespread not only in MPD"s but also in hematological malignancies, which might as well lead to the new classification of MPD"S. methyl protodioscin 205-208 Janus kinase 2 Homo sapiens 59-63 31669721-4 2019 Previous study has proposed that methylprotodioscin (MP) may promote cholesterol efflux by increasing ABCA1 expression. methyl protodioscin 33-51 ATP binding cassette subfamily A member 1 Homo sapiens 102-107 31669721-4 2019 Previous study has proposed that methylprotodioscin (MP) may promote cholesterol efflux by increasing ABCA1 expression. methyl protodioscin 53-55 ATP binding cassette subfamily A member 1 Homo sapiens 102-107 28301149-0 2017 Methyl Protodioscin Induces Apoptosis in Human Osteosarcoma Cells by Caspase-Dependent and MAPK Signaling Pathways. methyl protodioscin 0-19 mitogen-activated protein kinase 1 Homo sapiens 91-95 24205080-9 2013 Three potential compounds, methylprotodioscin, leonuride and catalpol, have been identified that bind to Cbl (RING) domain and interfere with the Cbl (RING)-UbCH7 protein-protein interaction. methyl protodioscin 27-45 Cbl proto-oncogene Homo sapiens 146-149 24205080-9 2013 Three potential compounds, methylprotodioscin, leonuride and catalpol, have been identified that bind to Cbl (RING) domain and interfere with the Cbl (RING)-UbCH7 protein-protein interaction. methyl protodioscin 27-45 ubiquitin conjugating enzyme E2 L3 Homo sapiens 157-162