PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15538122-3	2004	Because NADPH-oxidase/MPO may oxidize clozapine to highly reactive nitrenium ions, we investigated the role of hereditary polymorphisms in the NADPH oxidase/myeloperoxidase system in agranulocytosis patients who received clozapine (n = 49), ticlopidine (n = 11), and other drugs prior to the event.	nitrenium	67-76	myeloperoxidase	Homo sapiens	22-25
12919042-3	2003	In TFEA, spirodienones bearing the 1-azaspiro[4.5]decane skeleton are obtained by treatment of N-phthalimido-3-(4-halogenophenyl)propanamides with HTIB as a result of ipso attack of the intermediate nitrenium ion.	nitrenium	199-208	transcription factor binding to IGHM enhancer 3	Homo sapiens	3-7
29851463-3	2018	The NAT enzyme activates an arylhydroxamic acid functionality into a nitrenium ion that reacts fast, covalently, and under neutral conditions with nucleophilic residues of neighboring proteins.	nitrenium	69-78	bromodomain containing 2	Homo sapiens	4-7
31725283-3	2019	The present study demonstrated that TFT was oxidized to a chemically reactive nitrenium ion by myeloperoxidase (MPO) occurring in neutrophils.	nitrenium	78-87	myeloperoxidase	Homo sapiens	95-110
31725283-3	2019	The present study demonstrated that TFT was oxidized to a chemically reactive nitrenium ion by myeloperoxidase (MPO) occurring in neutrophils.	nitrenium	78-87	myeloperoxidase	Homo sapiens	112-115
11525925-6	2001	P450 1B1 had the highest catalytic activities among P450 family 1 enzymes for the activation of 1-aminopyrene (1-AP) in the OAT-overexpressing strain NM2009, suggesting nitrenium ion formation via N-hydroxylation/O-acetylation.	nitrenium	169-178	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	0-8
31459169-1	2018	Nitrenium ion species are examined using computational methods (DFT, MP2, coupled-cluster, and a composite method, CBS-APNO) with a particular emphasis on nonaromatic species (i.e., those lacking an aromatic or heteroaromatic ring in direct conjugation with the formal nitrenium ion center.)	nitrenium	0-9	tryptase pseudogene 1	Homo sapiens	69-72
17542636-0	2007	Synthesis and decomposition of an ester derivative of the procarcinogen and promutagen, PhIP, 2-amino-1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridine: unusual nitrenium ion chemistry.	nitrenium	155-164	pleckstrin homology domain interacting protein	Homo sapiens	88-92
28984748-8	2018	Nitrenium ion is mainly synthesized by CYP3A4, CYP2D6, and myeloperoxidase system in leukocytes.	nitrenium	0-9	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	47-53
24410629-2	2014	The major event of the mechanism of their mutagenicity is N-hydroxylation by P450 enzymes, primarily P450 1A2 (CYP1A2), which leads to the formation of nitrenium ions that covalently modify nucleobases of DNA.	nitrenium	152-161	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	111-117
24185126-8	2014	The different hGSTP1-1 mutants showed slightly altered regioselectivities in formation of individual GSH conjugates of clozapine which suggests that the binding orientation of the reactive nitrenium ion of clozapine is affected by the mutations.	nitrenium	189-198	glutathione S-transferase pi 1	Homo sapiens	14-22
23786256-3	2013	These amines are activated by CYP450 1A1, apparently into hydroxylamines 8a-g that are likely metabolized into esters that ionize into nitrenium ions responsible for cellular damage.	nitrenium	135-144	solute carrier family 45 member 2	Homo sapiens	37-40
16083506-1	2005	BACKGROUND: N-acetyltransferase 2 is phase II metabolizing enzyme that participates in the bioconversion of heterocyclic arylamines into electrophilic nitrenium ions, which are important ultimate carcinogens that are directly implicated in tumor initiation process.	nitrenium	151-160	N-acetyltransferase 2	Homo sapiens	12-33
16137733-3	2006	First, it was shown that HCEC cells express sulfotransferase 1A1, which is needed to metabolize N-OH-PhIP to the corresponding N-sulfonyloxy derivative, the direct precursor molecule of genotoxic nitrenium ions.	nitrenium	196-205	sulfotransferase family 1A member 1	Homo sapiens	44-64