PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33804175-6	2021	Naturally-occurring carbazoles 1-3 showed the most potent growth inhibitory effects on wild-type p53-expressing cells, being heptaphylline (1) the most promising in all the investigated cell lines.	heptaphylline	125-138	tumor protein p53	Homo sapiens	97-100
25556496-0	2014	Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-kappaB (p65) pathways.	heptaphylline	0-13	BH3 interacting domain death agonist	Homo sapiens	76-79
25556496-0	2014	Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-kappaB (p65) pathways.	heptaphylline	0-13	AKT serine/threonine kinase 1	Homo sapiens	84-87
25556496-0	2014	Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-kappaB (p65) pathways.	heptaphylline	0-13	nuclear factor kappa B subunit 1	Homo sapiens	88-97
25556496-0	2014	Heptaphylline induces apoptosis in human colon adenocarcinoma cells through bid and Akt/NF-kappaB (p65) pathways.	heptaphylline	0-13	RELA proto-oncogene, NF-kB subunit	Homo sapiens	99-102
25556496-4	2014	The results showed that only heptaphylline, but not 7-methoxyheptaphylline, significantly significantly activated cleaved of caspase-3 and poly (ADP-ribose) polymerase (PARP-1) which resulted in HT-29 cell death.	heptaphylline	29-42	caspase 3	Homo sapiens	125-167
25556496-4	2014	The results showed that only heptaphylline, but not 7-methoxyheptaphylline, significantly significantly activated cleaved of caspase-3 and poly (ADP-ribose) polymerase (PARP-1) which resulted in HT-29 cell death.	heptaphylline	29-42	poly(ADP-ribose) polymerase 1	Homo sapiens	169-175
25556496-5	2014	We found that heptaphylline activated BH3 interacting-domain death agonist (Bid) and Bak, proapoptotic proteins.	heptaphylline	14-27	BH3 interacting domain death agonist	Homo sapiens	76-79
25556496-7	2014	In addition, heptaphylline inhibited activation of NF-kappaB/p65 (rel), a regulator of apoptotic regulating proteins by suppressing the activation of Akt and IKKalpha, upstream regulators of p65.	heptaphylline	13-26	nuclear factor kappa B subunit 1	Homo sapiens	51-60
25556496-7	2014	In addition, heptaphylline inhibited activation of NF-kappaB/p65 (rel), a regulator of apoptotic regulating proteins by suppressing the activation of Akt and IKKalpha, upstream regulators of p65.	heptaphylline	13-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	61-64
25556496-7	2014	In addition, heptaphylline inhibited activation of NF-kappaB/p65 (rel), a regulator of apoptotic regulating proteins by suppressing the activation of Akt and IKKalpha, upstream regulators of p65.	heptaphylline	13-26	AKT serine/threonine kinase 1	Homo sapiens	150-153
25556496-7	2014	In addition, heptaphylline inhibited activation of NF-kappaB/p65 (rel), a regulator of apoptotic regulating proteins by suppressing the activation of Akt and IKKalpha, upstream regulators of p65.	heptaphylline	13-26	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	158-166
25556496-7	2014	In addition, heptaphylline inhibited activation of NF-kappaB/p65 (rel), a regulator of apoptotic regulating proteins by suppressing the activation of Akt and IKKalpha, upstream regulators of p65.	heptaphylline	13-26	RELA proto-oncogene, NF-kB subunit	Homo sapiens	191-194
33804175-9	2021	The yeast assay showed a potential reactivation of mutant p53 by heptaphylline derivatives, including compound 1d.	heptaphylline	65-78	tumor protein p53	Homo sapiens	58-61
34077030-0	2021	Heptaphylline suppresses the proliferation and migration of human bladder cancer cells via induction of intrinsic apoptosis, autophagy and inhibition of beta-catenin signalling pathway.	heptaphylline	0-13	catenin beta 1	Homo sapiens	153-165
34077030-11	2021	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	annexin A5	Homo sapiens	13-22
34077030-11	2021	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	collagen type XI alpha 2 chain	Homo sapiens	172-176
34077030-11	2021	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	caspase 3	Homo sapiens	178-187
34077030-11	2021	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	caspase 9	Homo sapiens	192-201
34077030-12	2021	Additionally, Heptaphylline caused increase in Bax and decrease in Bcl-2 expression.	heptaphylline	14-27	BCL2 associated X, apoptosis regulator	Homo sapiens	47-50
34077030-12	2021	Additionally, Heptaphylline caused increase in Bax and decrease in Bcl-2 expression.	heptaphylline	14-27	BCL2 apoptosis regulator	Homo sapiens	67-72
34077030-13	2021	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	133-136
34077030-13	2021	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	autophagy related 5	Homo sapiens	138-142
34077030-13	2021	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	autophagy related 7	Homo sapiens	144-148
34077030-13	2021	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	beclin 1	Homo sapiens	153-161
34077030-13	2021	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	nucleoporin 62	Homo sapiens	189-192
32277642-0	2020	Heptaphylline suppresses the proliferation and migration of human bladder cancer cells via induction of intrinsic apoptosis, autophagy and inhibition of beta-catenin signalling pathway.	heptaphylline	0-13	catenin beta 1	Homo sapiens	153-165
32277642-11	2020	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	annexin A5	Homo sapiens	13-22
32277642-11	2020	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	collagen type XI alpha 2 chain	Homo sapiens	172-176
32277642-11	2020	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	caspase 3	Homo sapiens	178-187
32277642-11	2020	The DAPI and annexin V/PI staining showed that Heptaphylline induced apoptosis in the RT4 bladder cancer cells which was also accompanied by enhancement in the cleavage of PARP, caspase-3 and caspase-9.	heptaphylline	47-60	caspase 9	Homo sapiens	192-201
32277642-12	2020	Additionally, Heptaphylline caused increase in Bax and decrease in Bcl-2 expression.	heptaphylline	14-27	BCL2 associated X, apoptosis regulator	Homo sapiens	47-50
32277642-12	2020	Additionally, Heptaphylline caused increase in Bax and decrease in Bcl-2 expression.	heptaphylline	14-27	BCL2 apoptosis regulator	Homo sapiens	67-72
32277642-13	2020	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	133-136
32277642-13	2020	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	autophagy related 5	Homo sapiens	138-142
32277642-13	2020	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	autophagy related 7	Homo sapiens	144-148
32277642-13	2020	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	beclin 1	Homo sapiens	153-161
32277642-13	2020	Electron microscopic analysis showed that Heptaphylline also caused autophagy in the RT4 cells which was associated with increase in LC3, Atg5, Atg7 and Beclin-1 expression and decrease in p62 expression.	heptaphylline	42-55	nucleoporin 62	Homo sapiens	189-192