PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
10671534-3	2000	In the present study, the repair activities of hOGG1 and Fpg were compared using defined oligonucleotides containing 8-oxoG and a methylated analog of Fapy (me-Fapy) at the same site.	4,6-diamino-5-N-formamidopyrimidine	151-155	8-oxoguanine DNA glycosylase	Homo sapiens	47-52
15595846-0	2004	Mouse NEIL1 protein is specific for excision of 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine from oxidatively damaged DNA.	4,6-diamino-5-N-formamidopyrimidine	96-129	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	6-11
15595846-6	2004	This finding establishes that mNEIL1 and its functional homologue hNEIL1 possess common substrates, namely, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine.	4,6-diamino-5-N-formamidopyrimidine	156-189	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	30-36
15595846-6	2004	This finding establishes that mNEIL1 and its functional homologue hNEIL1 possess common substrates, namely, 2,6-diamino-4-hydroxy-5-formamidopyrimidine and 4,6-diamino-5-formamidopyrimidine.	4,6-diamino-5-N-formamidopyrimidine	156-189	nei like DNA glycosylase 1	Homo sapiens	66-72
31733589-6	2020	Of all the measured DNA lesions, imidazole ring-opened 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) were preferentially released by both NEIL1 enzymes with K242R being  1.3 and 1.2-fold more efficient than K242 on excision of FapyAde and FapyGua, respectively.	4,6-diamino-5-N-formamidopyrimidine	55-88	nei like DNA glycosylase 1	Homo sapiens	194-199
35016673-5	2022	RESULTS: SP/GOx NPs can load drug molecules (Dox) and modify target molecule (FA-Py) on its surface conveniently.	4,6-diamino-5-N-formamidopyrimidine	78-83	hydroxyacid oxidase 1	Homo sapiens	12-15
35016673-6	2022	When the resultant FA-Py/SP/GOx/Dox NPs enters blood circulation, FA-Py will target it to cancer cells efficiently, where GOx can catalyst the overexpressed glucose to generate H2O2.	4,6-diamino-5-N-formamidopyrimidine	19-24	hydroxyacid oxidase 1	Homo sapiens	28-31
35016673-6	2022	When the resultant FA-Py/SP/GOx/Dox NPs enters blood circulation, FA-Py will target it to cancer cells efficiently, where GOx can catalyst the overexpressed glucose to generate H2O2.	4,6-diamino-5-N-formamidopyrimidine	19-24	hydroxyacid oxidase 1	Homo sapiens	122-125
35016673-6	2022	When the resultant FA-Py/SP/GOx/Dox NPs enters blood circulation, FA-Py will target it to cancer cells efficiently, where GOx can catalyst the overexpressed glucose to generate H2O2.	4,6-diamino-5-N-formamidopyrimidine	66-71	hydroxyacid oxidase 1	Homo sapiens	28-31
35016673-6	2022	When the resultant FA-Py/SP/GOx/Dox NPs enters blood circulation, FA-Py will target it to cancer cells efficiently, where GOx can catalyst the overexpressed glucose to generate H2O2.	4,6-diamino-5-N-formamidopyrimidine	66-71	hydroxyacid oxidase 1	Homo sapiens	122-125
35016673-9	2022	CONCLUSION: All the experiments showed that the excellent antitumor performance of FA-Py/SP/GOx/Dox NPs, which provided an new method for pillar(5)arene-based supramolecular polymer for biomedical applications.	4,6-diamino-5-N-formamidopyrimidine	83-88	hydroxyacid oxidase 1	Homo sapiens	92-95
9241232-1	1997	The OGG1 gene of Saccharomyces cerevisiae codes for a DNA glycosylase that excises 7,8-dihydro-8- oxoguanine (8-OxoG) and 2,6-diamino-4-hydroxy-5- N -methylformamidopyrimidine (Fapy) from damaged DNA.	4,6-diamino-5-N-formamidopyrimidine	177-181	8-oxoguanine glycosylase OGG1	Saccharomyces cerevisiae S288C	4-8
7827031-10	1995	4,6-Diamino-5-formamidopyrimidine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine may be produced by hydration of adenine and guanine, respectively, across the N(7)-C(8) double bond by mechanisms similar to those proposed previously for well-known formation of pyrimidine hydrates with the hydroxyl group located at C(6).	4,6-diamino-5-N-formamidopyrimidine	0-33	homeobox C8	Homo sapiens	165-169
7827031-10	1995	4,6-Diamino-5-formamidopyrimidine and 2,6-diamino-4-hydroxy-5-formamidopyrimidine may be produced by hydration of adenine and guanine, respectively, across the N(7)-C(8) double bond by mechanisms similar to those proposed previously for well-known formation of pyrimidine hydrates with the hydroxyl group located at C(6).	4,6-diamino-5-N-formamidopyrimidine	0-33	complement C6	Homo sapiens	316-320
24406253-6	2014	A novel 4,6-diamino-5-formamidopyrimidine (FapyA) specific incision activity of NEIL2 was also stimulated by CSB.	4,6-diamino-5-N-formamidopyrimidine	8-41	nei like DNA glycosylase 2	Homo sapiens	80-85
24406253-6	2014	A novel 4,6-diamino-5-formamidopyrimidine (FapyA) specific incision activity of NEIL2 was also stimulated by CSB.	4,6-diamino-5-N-formamidopyrimidine	8-41	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	109-112
20067321-2	2010	NEIL1 exhibits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) from DNA with no specificity for 8-hydroxyguanine (8-OH-Gua).	4,6-diamino-5-N-formamidopyrimidine	51-84	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	0-5
20067321-2	2010	NEIL1 exhibits a strong preference for excision of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) from DNA with no specificity for 8-hydroxyguanine (8-OH-Gua).	4,6-diamino-5-N-formamidopyrimidine	86-93	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	0-5
19179336-5	2009	This study examines the role of CSB in the repair of formamidopyrimidines 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde), which are substrates for endonuclease VIII-like (NEIL1) DNA glycosylase.	4,6-diamino-5-N-formamidopyrimidine	132-165	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	32-35
19179336-5	2009	This study examines the role of CSB in the repair of formamidopyrimidines 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) and 4,6-diamino-5-formamidopyrimidine (FapyAde), which are substrates for endonuclease VIII-like (NEIL1) DNA glycosylase.	4,6-diamino-5-N-formamidopyrimidine	167-174	ERCC excision repair 6, chromatin remodeling factor	Homo sapiens	32-35
19346169-8	2009	In contrast, the content of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) derived from adenine and guanine, respectively, were increased in some but not all tissues of Neil1-/- and Neil1-/-Nth1-/- mice.	4,6-diamino-5-N-formamidopyrimidine	28-61	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	224-229
19346169-8	2009	In contrast, the content of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) derived from adenine and guanine, respectively, were increased in some but not all tissues of Neil1-/- and Neil1-/-Nth1-/- mice.	4,6-diamino-5-N-formamidopyrimidine	28-61	nei endonuclease VIII-like 1 (E. coli)	Mus musculus	237-242
19346169-8	2009	In contrast, the content of 4,6-diamino-5-formamidopyrimidine (FapyAde) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) derived from adenine and guanine, respectively, were increased in some but not all tissues of Neil1-/- and Neil1-/-Nth1-/- mice.	4,6-diamino-5-N-formamidopyrimidine	28-61	nuclear encoded tRNA histidine 1 (anticodon ATG)	Mus musculus	245-249