PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
11742110-2	2001	Because of its essential intracellular role, guanylate kinase is a target for a number of cancer chemotherapeutic agents such as 6-thioguanine and 8-azaguanine and is involved in antiviral drug activation.	Azaguanine	147-159	guanylate kinase 1	Mus musculus	45-61
12717825-3	2003	By using antisense technology, mutation analysis at HPRT locus (on which lesion-targeted mutation usually occurs) was conducted in human transgenic cell line FL-REV3(-) by 8-azaguanine screening, and mutation occurred on undamaged DNA template was detected by using a shuttle plasmid pZ189 as the probe in human transgenic cell lines 293-REV3(-) and FL-REV3(-).	Azaguanine	172-184	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	52-56
15983407-4	2005	This work reports the structure of human PNP in complex with guanosine (at 2.80 A resolution), 3"-deoxyguanosine (at 2.86 A resolution) and 8-azaguanine (at 2.85 A resolution).	Azaguanine	140-152	purine nucleoside phosphorylase	Homo sapiens	41-44
21059307-2	2001	METHODS: The HGPRT-defective cell line was gradually induced by 8-AG ( 8-azaguanine) from the Lewis lung carcinoma cell line( L3-8) .	Azaguanine	64-68	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	13-18
21059307-2	2001	METHODS: The HGPRT-defective cell line was gradually induced by 8-AG ( 8-azaguanine) from the Lewis lung carcinoma cell line( L3-8) .	Azaguanine	71-83	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	13-18
11765016-2	2001	Independent 8-azaguanine-resistant clones were isolated, and base substitutions at the hypoxanthine (guanine) phosphoribosyltransferase (hprt) locus were determined.	Azaguanine	12-24	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	87-135
11361142-6	2001	In striking contrast, inhibition by 8-azaguanine and 8-mercaptoguanine was GFRP-independent and pH-independent.	Azaguanine	36-48	GTP cyclohydrolase I feedback regulator	Homo sapiens	75-79
8297116-1	1993	A monoclonal anti-CEA secreting hybridoma (11-285-14) was made hypoxanthine, aminopterin and thymidine (HAT) sensitive by back selecting it in increasing concentrations of 8-azaguanine.	Azaguanine	172-184	carcinoembryonic antigen gene family	Mus musculus	18-21
11063676-6	2000	First, guk1 and hpt1 mutants share several phenotypes, such as adenine derepression, purine excretion, and 8-azaguanine resistance.	Azaguanine	107-119	guanylate kinase	Saccharomyces cerevisiae S288C	7-11
11063676-6	2000	First, guk1 and hpt1 mutants share several phenotypes, such as adenine derepression, purine excretion, and 8-azaguanine resistance.	Azaguanine	107-119	hypoxanthine phosphoribosyltransferase	Saccharomyces cerevisiae S288C	16-20
20880464-2	1999	METHODS: An HGPRT (hypoxanthine guanidine phosphoribosyl transferase)-defective cell line , ALA9702 , was gradually induced by 8-azaguanine (8-AG) from mouse lung cancer cell line , LA795 .	Azaguanine	127-139	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	12-17
20880464-2	1999	METHODS: An HGPRT (hypoxanthine guanidine phosphoribosyl transferase)-defective cell line , ALA9702 , was gradually induced by 8-azaguanine (8-AG) from mouse lung cancer cell line , LA795 .	Azaguanine	127-139	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	19-68
20880464-2	1999	METHODS: An HGPRT (hypoxanthine guanidine phosphoribosyl transferase)-defective cell line , ALA9702 , was gradually induced by 8-azaguanine (8-AG) from mouse lung cancer cell line , LA795 .	Azaguanine	141-145	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	12-17
20880464-2	1999	METHODS: An HGPRT (hypoxanthine guanidine phosphoribosyl transferase)-defective cell line , ALA9702 , was gradually induced by 8-azaguanine (8-AG) from mouse lung cancer cell line , LA795 .	Azaguanine	141-145	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	19-68
11819377-2	1999	To observe their metastatic ability, they were inoculated into mice foodtaps and the drainage lymph nodes were examined under microscope.RESULTS:The end concentration of 8-Ag which was used to select HGPRT deficient Hca-P cells was 30mg/L.All the cells selected died in HAT culture medium in one week.Fused cells appeared approximately 9 days later.	Azaguanine	170-174	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	200-205
12426160-2	2001	METHODS: Mouse hybridoma cell line secreting anti-human CD3 monoclonal antibody (mAb) was trans formed into HAT-sensitive cells by 8-azaguanine, which was subsequently transfected by plasmid pCDaA3 containing neoR marker gene via FuGENETM6.	Azaguanine	131-143	CD3 antigen, epsilon polypeptide	Mus musculus	56-59
10534116-1	1999	Chronic intermittent injection of carbon tetrachloride (CCl4) for more than 10 weeks induced liver fibrosis in mice, as evidenced by positive Azan staining and increased intrahepatic collagen content.	Azaguanine	142-146	chemokine (C-C motif) ligand 4	Mus musculus	56-60
8632418-1	1996	Phosphonate acyclic derivates of guanines, pyrazolo[3,4-d]pyrimidines, and triazolo[4,5-d]-pyrimidines (8-azaguanines) are inhibitors of the enzyme purine nucleoside phosphorylase (PNPase) with Ki" values ranging from 0.05 to 1.6 microM.	Azaguanine	104-117	polyribonucleotide nucleotidyltransferase 1	Homo sapiens	181-187
8297116-2	1993	Eight 8-azaguanine resistant fusion partners were selected based on growth characteristics and continued anti-CEA production.	Azaguanine	6-18	carcinoembryonic antigen gene family	Mus musculus	110-113
1303821-3	1992	An HGPRT- cell line, CC-801AR2, was established from cloned human cervical carcinoma cell line CC-801 by using MNNG to induce cell mutation and 8-azaguanine (8-AG) to select the 8-AG resistant cells.	Azaguanine	144-156	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	3-8
1303821-3	1992	An HGPRT- cell line, CC-801AR2, was established from cloned human cervical carcinoma cell line CC-801 by using MNNG to induce cell mutation and 8-azaguanine (8-AG) to select the 8-AG resistant cells.	Azaguanine	158-162	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	3-8
1303821-3	1992	An HGPRT- cell line, CC-801AR2, was established from cloned human cervical carcinoma cell line CC-801 by using MNNG to induce cell mutation and 8-azaguanine (8-AG) to select the 8-AG resistant cells.	Azaguanine	178-182	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	3-8
34843735-6	2022	Tetraazatricyclo-dodecane (TATD) and 8-Azaguanine (8-Aza) were previously identified as potential binders to IAg7 of the NOD mice using in silico drug screening.	Azaguanine	37-49	I-ag7	Mus musculus	109-113
2157296-1	1990	Interleukin-3 (IL-3) -dependent cell lines were tested for spontaneous mutation frequency with respect to two markers, growth factor-independent growth and 8-azaguanine-resistant growth.	Azaguanine	156-168	interleukin 3	Homo sapiens	0-19
17055708-2	2007	The objective of this work was to study the CD26 membrane expression and DPPIV activity in T-acute leukaemia cell lines (CEM and MOLT3) in culture, in order to observe the modification of its expression under the 8-azaguanine treatment.	Azaguanine	213-225	dipeptidyl peptidase 4	Homo sapiens	44-48
17055708-6	2007	In the same experimental conditions, MOLT3 cell treated with 8-azaguanine shows an increase in CD26 expression (MIF) compared with that of CEM cell submitted to the same conditions (65.4+/-1.3 versus 18.7+/-1.7).	Azaguanine	61-73	dipeptidyl peptidase 4	Homo sapiens	95-99
17055708-6	2007	In the same experimental conditions, MOLT3 cell treated with 8-azaguanine shows an increase in CD26 expression (MIF) compared with that of CEM cell submitted to the same conditions (65.4+/-1.3 versus 18.7+/-1.7).	Azaguanine	61-73	macrophage migration inhibitory factor	Homo sapiens	112-115
17055708-8	2007	These preliminary results suggest that 8-azaguanine stimulates CD26 expression which may be related to cellular sensitivity to 8-azaguanine.	Azaguanine	39-51	dipeptidyl peptidase 4	Homo sapiens	63-67
17055708-8	2007	These preliminary results suggest that 8-azaguanine stimulates CD26 expression which may be related to cellular sensitivity to 8-azaguanine.	Azaguanine	127-139	dipeptidyl peptidase 4	Homo sapiens	63-67
34843735-6	2022	Tetraazatricyclo-dodecane (TATD) and 8-Azaguanine (8-Aza) were previously identified as potential binders to IAg7 of the NOD mice using in silico drug screening.	Azaguanine	51-56	I-ag7	Mus musculus	109-113
2942307-1	1986	The effect of nicotinamide or benzamide, inhibitors of poly(ADP-ribose)polymerase activity, on X-ray and ultraviolet light induced killing of asynchronously dividing V79 Chinese hamster cells was to reduce the shoulder width of the survival curve; the rate of killing remaining unchanged and the yield of 8-azaguanine resistant mutants also remaining unaffected.	Azaguanine	305-317	poly [ADP-ribose] polymerase 1	Cricetulus griseus	55-81
34646412-10	2021	We predict small molecules to inhibit TIMELESS such as 8-azaguanine, gw8510, 6-thioguanosine, and ursodeoxycholic acid.	Azaguanine	55-67	timeless circadian regulator	Homo sapiens	38-46
34318732-2	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	70-82	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	97-144
34318732-2	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	70-82	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	146-151
34318732-2	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	84-88	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	97-144
34318732-2	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	84-88	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	146-151
34318732-14	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	70-82	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	97-144
34318732-14	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	70-82	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	146-151
34318732-14	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	84-88	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	97-144
34318732-14	2021	METHODS: A549 cells were induced by ethyl methane sulfonate (EMS) and 8-azaguanine (8-AG) to get hypoxanthine guanine phosphoribosyl transferase (HGPRT) auxotrophic A549 cells.	Azaguanine	84-88	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	146-151
2598410-3	1989	The guanine analogs, 6-thioguanine and 8-azaguanine, induce granulocytic differentiation of HGPRT-deficient HL-60 promyelocytes.	Azaguanine	39-51	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	92-97
3259875-1	1988	A subclone, designated CEM-ON, derived from an azaguanine-resistant human leukemic T cell line, CEM-AG(R), constitutively secretes a colony-stimulating factor (CSF) which stimulates the production of macrophages from murine bone marrow progenitor cells.	Azaguanine	47-57	colony stimulating factor 2	Homo sapiens	160-163
34470864-2	2021	HGPRT will recognize 8-AG as a substrate and convert it to the monophosphate nucleotide.	Azaguanine	21-25	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	0-5
34470864-4	2021	Therefore, cells with a functional HGPRT enzyme grown in the presence of 8-AG will die.	Azaguanine	73-77	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	35-40
34470864-5	2021	Cells that are deficient in HGPRTase cannot incorporate 8-AG in vivo and thus continue to grow.	Azaguanine	56-60	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	28-36
3988817-0	1985	Metabolic properties of an azaguanine-resistant variant of Chinese hamster ovary cells (azarts) with normal levels of hypoxanthine-guanine phosphoribosyltransferase activity.	Azaguanine	27-37	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	118-164
4042123-8	1985	The results suggest that 8-azaguanine and adenine enhance myocardial reactive hyperaemia possibly by inhibiting adenosine deaminase to degradate myocardial interstitial adenosine to inosine.	Azaguanine	25-37	adenosine deaminase	Canis lupus familiaris	112-131
6865989-0	1983	8-Azaguanine versus 6-thioguanine: influence on frequency and expression time of induced HGPRT- mutations in Chinese hamster V79 cells.	Azaguanine	0-12	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	89-94
6526001-2	1984	In the present study, hypoxanthine phosphoribosyltransferase (HPRT) has been investigated in fibroblasts of 19 patients from 16 different families with HPRT deficiency, concerning activity, incorporation of 14C-hypoxanthine, and growth in 8-azaguanine and HAT (hypoxanthine, azaserine, thymidine containing) selection media.	Azaguanine	239-251	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	62-66
6578855-1	1983	A mutant (HPRT-) cell line was obtained by a series of passages in the medium with 8-azaguanine on the basis of human erythromyeloleukemia K-562 cells.	Azaguanine	83-95	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	10-14
6604949-4	1983	The activated human AAT phenotype segregated concordantly with human chromosome 14 in 18 primarily HAT-selected and five azaguanine back-selected series XXII hybrids.	Azaguanine	121-131	serpin family A member 1	Homo sapiens	20-23
6188543-0	1983	Increased inhibition of HGPRT by IMP and GMP and higher levels of PRPP in an 8-azaguanine - hat resistant mutant of Chinese hamster cells.	Azaguanine	77-89	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	24-29
6865989-5	1983	This result seems to be best explained by the reported lower affinity of 8-azaguanine for the wild-type HGPRT enzyme, thus providing evidence that, in this gene-mutation assay, the phenotypic expression time has a physiological component.	Azaguanine	73-85	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	104-109
6221816-0	1982	[Establishment of a cell line (CNf-A) resistant to 8-azaguanine].	Azaguanine	51-63	NPHS1 adhesion molecule, nephrin	Homo sapiens	31-34
6807752-4	1982	In low resistant mutants (10(-4) M AZG) isolated by one step selection, the activity of GMP- and AMP-pyrophosphorylases was decreased, as compared with the initial sensitive strain.	Azaguanine	35-38	5'-nucleotidase, cytosolic II	Homo sapiens	88-91
6752950-5	1982	Mutations to 8-azaguanine resistance induced by 0.2 muM diol epoxide are reduced by 50% when tissue culture media also contains 2 muM ellagic acid.	Azaguanine	13-25	latexin	Homo sapiens	52-55
6752950-5	1982	Mutations to 8-azaguanine resistance induced by 0.2 muM diol epoxide are reduced by 50% when tissue culture media also contains 2 muM ellagic acid.	Azaguanine	13-25	latexin	Homo sapiens	130-133
6807752-5	1982	The stepwise increase of the mutants resistance to AZG resulted in increasing of resistance to 8-azaadenine and decreasing of the activity of GMP-pyrophosphorylase, while this did not affect the level of AMP-pyrophosphorylase.	Azaguanine	51-54	5'-nucleotidase, cytosolic II	Homo sapiens	142-145
6120196-1	1982	Stable T cell growth factor- (TCGF; IL 2) producing cloned T cell hybridoma lines were constructed by fusing murine alloantigen-activated T cells with the 8-azaguanine-resistant lymphoma line, BW5147.	Azaguanine	155-167	interleukin 2	Mus musculus	30-34
6120196-1	1982	Stable T cell growth factor- (TCGF; IL 2) producing cloned T cell hybridoma lines were constructed by fusing murine alloantigen-activated T cells with the 8-azaguanine-resistant lymphoma line, BW5147.	Azaguanine	155-167	interleukin 2	Mus musculus	36-40
6811144-2	1982	Hypoxanthine phosphoribosyltransferase (HPRT) activity in the mutants was determined for both hypoxanthine and azaguanine as substrates.	Azaguanine	111-121	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	0-38
7285360-0	1981	A sensitive new method for measurement of guanase with 8-azaguanine in bicine bis-hydroxy ethyl glycine buffer as substrate.	Azaguanine	55-67	guanine deaminase	Homo sapiens	42-49
7254356-1	1981	Indirect evidence implies that 8-azaguanine-resistant (AGr) lymphocytes in human peripheral blood are mutants associated with the loss of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus on the active X chromosome, the mutation frequency increasing linearly with age.	Azaguanine	31-43	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	142-188
7254356-1	1981	Indirect evidence implies that 8-azaguanine-resistant (AGr) lymphocytes in human peripheral blood are mutants associated with the loss of the hypoxanthine-guanine phosphoribosyltransferase (HPRT) locus on the active X chromosome, the mutation frequency increasing linearly with age.	Azaguanine	31-43	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	190-194
7029263-8	1981	Many studies depend on selecting for 8-azaguanine- or 6-thioguanine-resistant mutants, which are due to mutations in the HGPRT locus present in a single active copy on the X-chromosome.	Azaguanine	37-49	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	121-126
6811144-2	1982	Hypoxanthine phosphoribosyltransferase (HPRT) activity in the mutants was determined for both hypoxanthine and azaguanine as substrates.	Azaguanine	111-121	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	40-44
7273856-2	1981	8-Azaguanine and 6-thioguanine are synthetic analogs of guanine and are lethal to cells with normal hypoxanthine phosphoribosyltransferase (HPRT) activity.	Azaguanine	0-12	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	100-138
7273856-2	1981	8-Azaguanine and 6-thioguanine are synthetic analogs of guanine and are lethal to cells with normal hypoxanthine phosphoribosyltransferase (HPRT) activity.	Azaguanine	0-12	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	140-144
7273856-3	1981	In principle, however, HPRT-positive cells could become selectively resistant to 8-azaguanine if, by any mechanism, the cells expressed higher levels of guanine deaminase.	Azaguanine	81-93	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	23-27
7273856-3	1981	In principle, however, HPRT-positive cells could become selectively resistant to 8-azaguanine if, by any mechanism, the cells expressed higher levels of guanine deaminase.	Azaguanine	81-93	guanine deaminase	Homo sapiens	153-170
7273856-5	1981	Our study shows that HPRT-positive cells inherently resistant to relatively high levels of 8-azaguanine contain high levels of guanine deaminase.	Azaguanine	91-103	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	21-25
7273856-5	1981	Our study shows that HPRT-positive cells inherently resistant to relatively high levels of 8-azaguanine contain high levels of guanine deaminase.	Azaguanine	91-103	guanine deaminase	Homo sapiens	127-144
7273856-6	1981	In general, guanine deaminase activity was higher in 8-azaguanine-resistant cells, regardless of their HPRT activity.	Azaguanine	53-65	guanine deaminase	Homo sapiens	12-29
7273856-7	1981	Our results support the view that elevated guanine deaminase activity constitutes a potential mechanism of selective 8-azaguanine resistance in cells with normal HPRT activity.	Azaguanine	117-129	guanine deaminase	Homo sapiens	43-60
7273856-7	1981	Our results support the view that elevated guanine deaminase activity constitutes a potential mechanism of selective 8-azaguanine resistance in cells with normal HPRT activity.	Azaguanine	117-129	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	162-166
7273856-8	1981	Guanine deaminase levels were significantly elevated in HPRT-positive cells briefly exposed to sublethal concentrations of 8-azaguanine, but this elevation was transient.	Azaguanine	123-135	guanine deaminase	Homo sapiens	0-17
7273856-8	1981	Guanine deaminase levels were significantly elevated in HPRT-positive cells briefly exposed to sublethal concentrations of 8-azaguanine, but this elevation was transient.	Azaguanine	123-135	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	56-60
7207481-3	1981	Affinity of HGPRT for azaguanine was 10-fold lower than for hypoxanthine in both cell lines and was similar to that for thioguanine in V79S cells.	Azaguanine	22-32	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	12-17
7207481-8	1981	The slow rate of dissociation of the HGPRT-azaguanine complex is reflected in the slow rate of killing of wild-type cells.	Azaguanine	43-53	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	37-42
7207481-10	1981	Our data suggest that azaguanine and thioguanine may select for mutations at different sites on the HGPRT molecule in V79 cells and provide possible explanations for the differences in effectiveness of these two agents reported in other cell lines.	Azaguanine	22-32	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	100-105
972164-4	1976	The results suggest that their basis for resistance resides in lowered incorporation of azaguanine into DNA and RNA, possibly due to a mofified HPRT molecule which accepts hypoxanthine, but not azaguanine as a substrate.	Azaguanine	88-98	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	144-148
7238512-6	1981	8-Azaguanine, which is known to be substrate of tRNA--guanine transglycosylase, was incorporated almost exclusively into the first position of hypo-modified tRNA in murine erythroleukemic cells when they were pulse-labeled in culture with 8-azaguanine, suggesting strongly that tRNA-guanine transglycosylase in the cells is actually involved in incorporation of 8-azaguanine into tRNA in vivo.	Azaguanine	0-12	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	48-78
7238512-6	1981	8-Azaguanine, which is known to be substrate of tRNA--guanine transglycosylase, was incorporated almost exclusively into the first position of hypo-modified tRNA in murine erythroleukemic cells when they were pulse-labeled in culture with 8-azaguanine, suggesting strongly that tRNA-guanine transglycosylase in the cells is actually involved in incorporation of 8-azaguanine into tRNA in vivo.	Azaguanine	0-12	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	278-307
7238512-6	1981	8-Azaguanine, which is known to be substrate of tRNA--guanine transglycosylase, was incorporated almost exclusively into the first position of hypo-modified tRNA in murine erythroleukemic cells when they were pulse-labeled in culture with 8-azaguanine, suggesting strongly that tRNA-guanine transglycosylase in the cells is actually involved in incorporation of 8-azaguanine into tRNA in vivo.	Azaguanine	239-251	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	48-78
7238512-6	1981	8-Azaguanine, which is known to be substrate of tRNA--guanine transglycosylase, was incorporated almost exclusively into the first position of hypo-modified tRNA in murine erythroleukemic cells when they were pulse-labeled in culture with 8-azaguanine, suggesting strongly that tRNA-guanine transglycosylase in the cells is actually involved in incorporation of 8-azaguanine into tRNA in vivo.	Azaguanine	362-374	queuine tRNA-ribosyltransferase catalytic subunit 1	Mus musculus	48-78
514305-1	1979	The mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRTase) locus in Chinese hamster V79 cells induced by metal cations were examined by the development of resistance to 8-azaguanine (8AG).	Azaguanine	190-202	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	21-68
514305-1	1979	The mutations at the hypoxanthine-guanine phosphoribosyl transferase (HGPRTase) locus in Chinese hamster V79 cells induced by metal cations were examined by the development of resistance to 8-azaguanine (8AG).	Azaguanine	190-202	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	70-78
514305-3	1979	About 75% of 8AG-resistant colonies were sensitive to amethopterin, and 86% of the resistant colonies showed less than 3% of the HGPRTase activity of the wild-type cells.	Azaguanine	13-16	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	129-137
291939-8	1979	Because the Chinese hamster cell line (380) used for cell hybridization is deficient in hypoxanthine phosphoribosyltransferase (HPRT; IMP: pyrophosphate phosphoribosyltransferase, EC 2.4.2.8), that part of the mouse X chromosome carrying the complementing Hprt gene can be identified by selection in hypoxanthine/aminopterin/thymidine medium and counterselection in 8-azaguanine.	Azaguanine	366-378	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	88-126
762202-1	1979	Cellular resistance to the cytotoxic purine analogues 8-azaguanine (AG) and 6-thioguanine (TG) is usually mediated by a mutation leading to the loss or reduction in hypoxanthine phosphoribosyltransferase (HPRT) activity.	Azaguanine	54-66	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	205-209
6935682-5	1980	These clones were then selected in medium containing 8-azaguanine to achieve the loss of the active human HPRT locus.	Azaguanine	53-65	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	106-110
7394700-5	1980	We also present evidence which shows that such mutants arise through a mutation that specifically alters the HPRT molecule so that the enzyme no longer recognizes 8-azaguanine as a substrate, while remaining catalytically functional with hypoxanthine and 6-thioguanine.	Azaguanine	163-175	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	109-113
7384171-1	1980	Guanine deaminase is an important enzyme of purine catabolism which irreversibly deaminates guanine (1) to xanthine (2) and also 8-azaguanine to 8-azaxanthine.	Azaguanine	129-141	guanine deaminase	Homo sapiens	0-17
7384171-4	1980	Inhibitors of guanine deaminase are important because it is reasonable to postulate that it will inhibit the conversion of 8-azaguanine to 8-azaxanthine and these could be used with advantage along with thioguanine and 8-azaguanine.	Azaguanine	123-135	guanine deaminase	Homo sapiens	14-31
7384171-4	1980	Inhibitors of guanine deaminase are important because it is reasonable to postulate that it will inhibit the conversion of 8-azaguanine to 8-azaxanthine and these could be used with advantage along with thioguanine and 8-azaguanine.	Azaguanine	219-231	guanine deaminase	Homo sapiens	14-31
6119798-2	1980	The autoradiographic determination of purine analogue (8-azaguanine; 6-thioguanine) resistant (AGr; TGr) peripheral blood lymphocytes (PBLs) arising in vivo in man is proposed as a candidate test.	Azaguanine	55-67	thioredoxin reductase 3	Homo sapiens	100-103
912745-1	1977	Chinese hamster cells selected for resistance to 8-azaguanine following mutagenesis have hypoxanthine-guanine phosphoribosyltransferase (HGPRT; E.C.	Azaguanine	49-61	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	89-135
912745-1	1977	Chinese hamster cells selected for resistance to 8-azaguanine following mutagenesis have hypoxanthine-guanine phosphoribosyltransferase (HGPRT; E.C.	Azaguanine	49-61	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	137-142
196813-2	1977	Segregation was controlled by taking advantage of the HAT/8-azaguanine selection-counterselection strategy directed at the X-linked HPRT locus.	Azaguanine	58-70	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	132-136
972164-4	1976	The results suggest that their basis for resistance resides in lowered incorporation of azaguanine into DNA and RNA, possibly due to a mofified HPRT molecule which accepts hypoxanthine, but not azaguanine as a substrate.	Azaguanine	194-204	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	144-148
1066695-2	1976	Distinction between gene transferents and revertants of the recipient mutant phenotype was achieved by the use of a donor strain carrying a mutationally altered (8-azaguanine-resistant) hypoxanthine-guanine phosphoribosyltransferase (HPRTase; IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8).	Azaguanine	162-174	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	186-232
58715-7	1976	Treatment with 8-azaguanine inhibited both increase of serum AFP levels, although the inhibition was much less or was insignificant in partially hepatectomized rats.	Azaguanine	15-27	alpha-fetoprotein	Rattus norvegicus	61-64
950955-5	1976	Evidence is presented to show that 6TG is a better selective agent than 8-aza-guanine (8AG) for HGPRT-deficient mutants of human diploid fibroblasts.	Azaguanine	72-85	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	96-101
950955-5	1976	Evidence is presented to show that 6TG is a better selective agent than 8-aza-guanine (8AG) for HGPRT-deficient mutants of human diploid fibroblasts.	Azaguanine	87-90	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	96-101
949906-3	1976	Back-selection of hybrid cells in 8-azaguanine for loss of HPRT resulted in the loss of the Xchromosome derived from the diploid parent, providing evidence of the X-linkage of the HPRT locus.	Azaguanine	34-46	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	59-63
949906-3	1976	Back-selection of hybrid cells in 8-azaguanine for loss of HPRT resulted in the loss of the Xchromosome derived from the diploid parent, providing evidence of the X-linkage of the HPRT locus.	Azaguanine	34-46	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	180-184
168203-4	1975	Cells of an azaguanine-resistant subline of Novikoff cells which lacked hypoxanthine-guanine phosphoribosyltransferase activity and failed to incorporate guanine or hypoxanthine into the nucleotide pool, exhibited uptake of guanine and hypoxanthine by a saturable process.	Azaguanine	12-22	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	72-118
30804405-8	2019	While steady-state protein synthesis was unaffected, SF3B1 mutant cells were more sensitive to the clinically-relevant purine analogue, 8-azaguanine.	Azaguanine	136-148	splicing factor 3b subunit 1	Homo sapiens	53-58
4843977-0	1974	The role of 8-azaguanine in the selection from human diploid cells of mutants deficient in hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT).	Azaguanine	12-24	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	91-138
4843977-0	1974	The role of 8-azaguanine in the selection from human diploid cells of mutants deficient in hypoxanthine-guanine-phosphoribosyl-transferase (HGPRT).	Azaguanine	12-24	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	140-145
4152244-0	1974	Effects of 8-azaguanine on the induction of uterine glucose-6-phosphate dehydrogenase activity by estradiol or NADP plus.	Azaguanine	11-23	glucose-6-phosphate dehydrogenase	Homo sapiens	52-85
4420822-0	1974	Xanthine dehydrogenase activity in starved-refed rats treated with 8-azaguanine.	Azaguanine	67-79	xanthine dehydrogenase	Rattus norvegicus	0-22
4358687-7	1973	Most mutants could utilize exogenous adenine, just as most azaguanine-resistant fibroblast mutants can utilize exogenous hypoxanthine, even when their hypoxanthine-guanine phosphoribosyltransferase activity is reduced.	Azaguanine	59-69	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	151-197
5048997-0	1972	Kinetic coupled optical assays for guanase activity at 340 nm utilizing guanine and 8-azaguanine as substrates.	Azaguanine	84-96	guanine deaminase	Homo sapiens	35-42
14790788-0	1950	The competitive inhibition of uricase activity by 8-azaguanine and by 8-azaxanthine.	Azaguanine	50-62	urate oxidase (pseudogene)	Homo sapiens	30-37
1240813-3	1975	The mutants of the 2nd group (Azg-Dap-r) are selected in the selective background of two analogues of 5-10(-3) M DAP and 10(-4) M 8-azaguanine (AG).	Azaguanine	130-142	pleckstrin homology domain containing M3	Homo sapiens	34-39
1196424-1	1975	By utilizing the selection system, a population of hybrid cells with the gene coding HGPRT and sensitive to 8-azaguanine (8-AG) was isolated from a mixed population of hybrid cells derived from malignant diploid HGPRT+ mouse lymphosarcoma cells (LS/BL) and L cells resistant to 8-AG (HGPRT-, R-AG/20 strain).	Azaguanine	108-120	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	85-90
1196424-1	1975	By utilizing the selection system, a population of hybrid cells with the gene coding HGPRT and sensitive to 8-azaguanine (8-AG) was isolated from a mixed population of hybrid cells derived from malignant diploid HGPRT+ mouse lymphosarcoma cells (LS/BL) and L cells resistant to 8-AG (HGPRT-, R-AG/20 strain).	Azaguanine	122-126	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	85-90
1196424-1	1975	By utilizing the selection system, a population of hybrid cells with the gene coding HGPRT and sensitive to 8-azaguanine (8-AG) was isolated from a mixed population of hybrid cells derived from malignant diploid HGPRT+ mouse lymphosarcoma cells (LS/BL) and L cells resistant to 8-AG (HGPRT-, R-AG/20 strain).	Azaguanine	278-282	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	85-90
1196424-2	1975	During back-selection of this hybrid population , cultivated in vitro, HGPRT- negative fractions of the cell population, resistant to 8-AG, appeared in a high frequency.	Azaguanine	134-138	hypoxanthine guanine phosphoribosyl transferase	Mus musculus	71-76
5022113-0	1972	Assay of human serum and liver guanase activity with 8-azaguanine as substrate.	Azaguanine	53-65	guanine deaminase	Homo sapiens	31-38
33907247-6	2021	Azan- and Sirius red-positive areas increased significantly in the octn1 knockout mice.	Azaguanine	0-4	solute carrier family 22 (organic cation transporter), member 4	Mus musculus	67-72
31944095-3	2020	Experimental studies showed that calf PNP ribosylates purine analogs in specific positions - 2,6-diamino-8-azapurine in positions 7 or 8 and 8-azaguanine in position 9 of the triazole ring.	Azaguanine	141-153	purine nucleoside phosphorylase	Bos taurus	38-41
31944095-5	2020	This hypothesis was verified by application of molecular modelling techniques to two complexes of purine analogs 2,6-diamino-azapurine - calf PNP (pdb-code: 1LVU) and 8-azaguanine - calf PNP (pdb-code: 2AI1).	Azaguanine	167-179	purine nucleoside phosphorylase	Bos taurus	187-190
30804405-10	2019	Our results suggest that the simultaneous targeting of RNA metabolism and splicing by 8-azaguanine represents a therapeutic opportunity for SF3B1-mutant myelodysplastic syndromes.	Azaguanine	86-98	splicing factor 3b subunit 1	Homo sapiens	140-145
21678408-8	2012	CD34(+) cell transplantation reduced liver fibrosis in a dose-dependent fashion, with decreased collagen type-I and alpha-SMA-positive cells after 6 weeks of CCl(4) treatment by Mallory"s Azan and immunohistochemical staining.	Azaguanine	188-192	CD34 molecule	Homo sapiens	0-4
27671122-11	2016	ECM stainings showed neocartilage-like structure with positive AZAN staining as well as collagen type II and aggrecan deposition after three weeks of cultivation.	Azaguanine	63-67	multimerin 1	Homo sapiens	0-3
23682724-8	2013	In contrast, Sirius Red and Azan staining showed significantly more severe hepatic fibrosis in HNP-1 transgenic mice compared with wild-type mice.	Azaguanine	28-32	HNP1	Homo sapiens	95-100
24126376-7	2013	Ribosylation of 8-azaguanine with calf PNP as a catalyst goes exclusively to N9.	Azaguanine	16-28	purine nucleoside phosphorylase	Bos taurus	39-42
28353090-9	2017	Azan staining showed that fibrous matrix deposition varied among pituitary adenomas and that the area of fibrosis was associated with the number and number of types of TIMP3-expressing cells.	Azaguanine	0-4	TIMP metallopeptidase inhibitor 3	Homo sapiens	168-173
26586723-8	2016	First, we discovered 8-azaguanine, an antimetabolite that is activated by hypoxanthine phosphoribosyltransferase 1 (HPRT1), suggesting an elevated gene-dosage of HPRT1 in high-ploidy tumors can control sensitivity to this drug.	Azaguanine	21-33	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	74-114
26586723-8	2016	First, we discovered 8-azaguanine, an antimetabolite that is activated by hypoxanthine phosphoribosyltransferase 1 (HPRT1), suggesting an elevated gene-dosage of HPRT1 in high-ploidy tumors can control sensitivity to this drug.	Azaguanine	21-33	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	116-121
26586723-8	2016	First, we discovered 8-azaguanine, an antimetabolite that is activated by hypoxanthine phosphoribosyltransferase 1 (HPRT1), suggesting an elevated gene-dosage of HPRT1 in high-ploidy tumors can control sensitivity to this drug.	Azaguanine	21-33	hypoxanthine phosphoribosyltransferase 1	Homo sapiens	162-167
26729076-1	2015	Enzymatic ribosylation of fluorescent 8-azapurine derivatives, like 8-azaguanine and 2,6-diamino-8-azapurine, with purine-nucleoside phosphorylase (PNP) as a catalyst, leads to N9, N8, and N7-ribosides.	Azaguanine	68-80	purine nucleoside phosphorylase	Homo sapiens	115-146
26729076-1	2015	Enzymatic ribosylation of fluorescent 8-azapurine derivatives, like 8-azaguanine and 2,6-diamino-8-azapurine, with purine-nucleoside phosphorylase (PNP) as a catalyst, leads to N9, N8, and N7-ribosides.	Azaguanine	68-80	purine nucleoside phosphorylase	Homo sapiens	148-151
25387119-5	2014	Furthermore, recent developments of novel alpha4beta2*-nAChR-specific PET radioligands, such as (-)[18F]Flubatine or [18F]AZAN are summarized.	Azaguanine	122-126	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	55-60
24211442-3	2014	In this study, mutations induced in the CAN1 gene of yeast Saccharomyces cerevisiae by the representative mutagen 3-azido-1,2-propanediol (azidoglycerol, AZG) have been sequenced.	Azaguanine	154-157	arginine permease CAN1	Saccharomyces cerevisiae S288C	40-44
21541747-0	2012	Study of the interaction between 8-azaguanine and bovine serum albumin using optical spectroscopy and molecular modeling methods.	Azaguanine	33-45	albumin	Homo sapiens	57-70
21541747-1	2012	The interaction between 8-azaguanine (8-Azan) and bovine serum albumin (BSA) in Tris-HCl buffer solutions at pH 7.4 was investigated by means of fluorescence and ultraviolet-visible (UV-Vis) spectroscopy.	Azaguanine	24-36	albumin	Homo sapiens	57-70
21541747-1	2012	The interaction between 8-azaguanine (8-Azan) and bovine serum albumin (BSA) in Tris-HCl buffer solutions at pH 7.4 was investigated by means of fluorescence and ultraviolet-visible (UV-Vis) spectroscopy.	Azaguanine	38-44	albumin	Homo sapiens	57-70
21451526-8	2011	Deficiency in CX3CR1 inhibited kidney fibrosis, as evidenced by a decrease in the presence of interstitial fibrotic area detected by type I collagen in Mallory-Azan staining, concomitant with the downregulation of transforming growth factor (TGF)-beta(1) and type I procollagen mRNA expression in damaged kidneys.	Azaguanine	160-164	chemokine (C-X3-C motif) receptor 1	Mus musculus	14-20
21049046-8	2010	A single injection of 0.5 nM miR-200b precursor was sufficient to inhibit the increase of collagen types I, III and fibronectin in obstructed kidneys, and amelioration of fibrosis was confirmed by observation of the kidneys with Azan staining.	Azaguanine	229-233	microRNA 200b	Mus musculus	29-37
19121308-3	2009	Analysis of single and double mutant lines harboring T-DNA insertion alleles AtAzg1-1 and AtAzg2-1 reveal a marked resistance to growth in the presence of 8-azaadenine and 8-azaguanine but not to other toxic nucleobase analogues.	Azaguanine	172-184	AZA-guanine resistant1	Arabidopsis thaliana	77-85
19289825-6	2009	Also, this betaarr1-mediated pathway appears capable of promoting aldosterone turnover independently of G protein activation, because treatment of AZG cells with SII, an AngII analog that induces betaarr, but not G protein coupling to the AT(1)R, recapitulates the effects of AngII on aldosterone production and secretion.	Azaguanine	147-150	arrestin beta 1	Homo sapiens	11-19
19303028-9	2010	SIGNIFICANCE: The continuous efforts of radiomedicinal chemists led to the development of several interesting PET radioligands for imaging of nAChR including [(18)F]AZAN, a potentially superior alternative to 2-[(18)F]FA.	Azaguanine	165-169	cholinergic receptor nicotinic alpha 4 subunit	Homo sapiens	142-147
19121308-3	2009	Analysis of single and double mutant lines harboring T-DNA insertion alleles AtAzg1-1 and AtAzg2-1 reveal a marked resistance to growth in the presence of 8-azaadenine and 8-azaguanine but not to other toxic nucleobase analogues.	Azaguanine	172-184	Xanthine/uracil permease family protein	Arabidopsis thaliana	90-96
19121308-4	2009	Conversely, yeast strains expressing AtAzg1 and AtAzg2 gain heightened sensitivity to growth on 8-azaadenine and 8-azaguanine.	Azaguanine	113-125	AZA-guanine resistant1	Arabidopsis thaliana	37-43
19121308-4	2009	Conversely, yeast strains expressing AtAzg1 and AtAzg2 gain heightened sensitivity to growth on 8-azaadenine and 8-azaguanine.	Azaguanine	113-125	Xanthine/uracil permease family protein	Arabidopsis thaliana	48-54