PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31919413-0	2020	GSK3beta is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ.	2,3-dimethoxy-1,4-naphthoquinone	87-91	glycogen synthase kinase 3 alpha	Homo sapiens	0-8
31919413-6	2020	Using the quinone DMNQ, a ROS generator, we demonstrate that GSK3beta is involved in the regulation of ROS-dependent necrosis.	2,3-dimethoxy-1,4-naphthoquinone	18-22	glycogen synthase kinase 3 alpha	Homo sapiens	61-69
31919413-10	2020	Accumulation of ROS in response to DMNQ is impaired by the absence of GSK3beta.	2,3-dimethoxy-1,4-naphthoquinone	35-39	glycogen synthase kinase 3 alpha	Homo sapiens	70-78
31919413-11	2020	We provide evidence that the activities of the obligatory two-electrons reducing flavoenzymes, NQO1 (NAD(P)H quinone dehydrogenase 1) and NQO2 are required to suppress DMNQ-induced necrosis.	2,3-dimethoxy-1,4-naphthoquinone	168-172	NAD(P)H quinone dehydrogenase 1	Homo sapiens	95-99
31919413-11	2020	We provide evidence that the activities of the obligatory two-electrons reducing flavoenzymes, NQO1 (NAD(P)H quinone dehydrogenase 1) and NQO2 are required to suppress DMNQ-induced necrosis.	2,3-dimethoxy-1,4-naphthoquinone	168-172	NAD(P)H quinone dehydrogenase 1	Homo sapiens	101-132
31919413-11	2020	We provide evidence that the activities of the obligatory two-electrons reducing flavoenzymes, NQO1 (NAD(P)H quinone dehydrogenase 1) and NQO2 are required to suppress DMNQ-induced necrosis.	2,3-dimethoxy-1,4-naphthoquinone	168-172	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	138-142
31919413-13	2020	In summary, GSK3beta by blunting the anti-oxidant response and particularly NQO1 and NQO2 expression, favors the appearance of necrosis in response to ROS, as generated by the quinone DMNQ.	2,3-dimethoxy-1,4-naphthoquinone	184-188	glycogen synthase kinase 3 alpha	Homo sapiens	12-20
26596413-8	2015	Treatment of cultured cardiac fibroblasts with an oxidative stress-inducing agent (DMNQ) induces autophagy and intracellular procollagen I and fibronectin degradation, which is reversed by wortmannin but not by the global MMP inhibitor (PD166793).	2,3-dimethoxy-1,4-naphthoquinone	83-87	fibronectin 1	Rattus norvegicus	143-154
30590195-4	2019	RESULTS: Treatment of femoral and talar chondrocytes with menadione, DMNQ or FN-f led to a time dependent increase in extracellular-regulated kinase (ERK) and p38 phosphorylation.	2,3-dimethoxy-1,4-naphthoquinone	69-73	mitogen-activated protein kinase 1	Homo sapiens	118-148
30590195-4	2019	RESULTS: Treatment of femoral and talar chondrocytes with menadione, DMNQ or FN-f led to a time dependent increase in extracellular-regulated kinase (ERK) and p38 phosphorylation.	2,3-dimethoxy-1,4-naphthoquinone	69-73	mitogen-activated protein kinase 1	Homo sapiens	150-153
30590195-4	2019	RESULTS: Treatment of femoral and talar chondrocytes with menadione, DMNQ or FN-f led to a time dependent increase in extracellular-regulated kinase (ERK) and p38 phosphorylation.	2,3-dimethoxy-1,4-naphthoquinone	69-73	mitogen-activated protein kinase 1	Homo sapiens	159-162
30590195-5	2019	DMNQ and FN-f stimulation enhanced phosphorylation of JNK and its downstream substrate, c-Jun.	2,3-dimethoxy-1,4-naphthoquinone	0-4	mitogen-activated protein kinase 8	Homo sapiens	54-57
30590195-5	2019	DMNQ and FN-f stimulation enhanced phosphorylation of JNK and its downstream substrate, c-Jun.	2,3-dimethoxy-1,4-naphthoquinone	0-4	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	88-93
31326607-7	2019	In HT22 cells, DMNQ treatment appeared to tilt the mitochondrial fusion-fission balance toward fission by down-regulating the levels of profusion proteins (MFN1/2 and OPA1) and inhibitory phosphorylation of profission protein DRP1 at Ser-637, resulting in mitochondrial fragmentation.	2,3-dimethoxy-1,4-naphthoquinone	15-19	mitofusin 1	Mus musculus	156-162
31326607-7	2019	In HT22 cells, DMNQ treatment appeared to tilt the mitochondrial fusion-fission balance toward fission by down-regulating the levels of profusion proteins (MFN1/2 and OPA1) and inhibitory phosphorylation of profission protein DRP1 at Ser-637, resulting in mitochondrial fragmentation.	2,3-dimethoxy-1,4-naphthoquinone	15-19	OPA1, mitochondrial dynamin like GTPase	Mus musculus	167-171
31326607-7	2019	In HT22 cells, DMNQ treatment appeared to tilt the mitochondrial fusion-fission balance toward fission by down-regulating the levels of profusion proteins (MFN1/2 and OPA1) and inhibitory phosphorylation of profission protein DRP1 at Ser-637, resulting in mitochondrial fragmentation.	2,3-dimethoxy-1,4-naphthoquinone	15-19	collapsin response mediator protein 1	Mus musculus	226-230
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	2,3-dimethoxy-1,4-naphthoquinone	0-32	sirtuin 2	Mus musculus	105-110
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	2,3-dimethoxy-1,4-naphthoquinone	0-32	sirtuin 6	Mus musculus	115-120
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	2,3-dimethoxy-1,4-naphthoquinone	34-38	sirtuin 2	Mus musculus	105-110
26896748-5	2016	2,3-dimethoxy-1,4-naphthoquinone (DMNQ), a superoxide generating agent, mimicked high glucose-suppressed SIRT2 and SIRT6 expression.	2,3-dimethoxy-1,4-naphthoquinone	34-38	sirtuin 6	Mus musculus	115-120
25096578-3	2014	The mitochondrial reactive oxygen species generator 2,3-dimethoxy-1,4-naphthoquinone elicits necrosis characterized by the involvement of RIP1 and Drp1.	2,3-dimethoxy-1,4-naphthoquinone	52-84	receptor interacting serine/threonine kinase 1	Homo sapiens	138-142
25096578-3	2014	The mitochondrial reactive oxygen species generator 2,3-dimethoxy-1,4-naphthoquinone elicits necrosis characterized by the involvement of RIP1 and Drp1.	2,3-dimethoxy-1,4-naphthoquinone	52-84	collapsin response mediator protein 1	Homo sapiens	147-151
24134844-0	2013	Inhibitory effects of LPA1 on cell motile activities stimulated by hydrogen peroxide and 2,3-dimethoxy-1,4-naphthoquinone in fibroblast 3T3 cells.	2,3-dimethoxy-1,4-naphthoquinone	89-121	lysophosphatidic acid receptor 1	Mus musculus	22-26
24134844-5	2013	3T3 cells treated with hydrogen peroxide and DMNQ showed elevated expression levels of the Lpar3 gene, but not the Lpar1 and Lpar2 genes.	2,3-dimethoxy-1,4-naphthoquinone	45-49	lysophosphatidic acid receptor 3	Mus musculus	91-96
21367861-5	2011	Intracellular reactive oxygen species levels in cells treated with 2,3-dimethoxy-1,4-naphthoquinone were mitigated in a VKORC1L1 expression-dependent manner.	2,3-dimethoxy-1,4-naphthoquinone	67-99	vitamin K epoxide reductase complex subunit 1 like 1	Homo sapiens	120-128
24134844-5	2013	3T3 cells treated with hydrogen peroxide and DMNQ showed elevated expression levels of the Lpar3 gene, but not the Lpar1 and Lpar2 genes.	2,3-dimethoxy-1,4-naphthoquinone	45-49	lysophosphatidic acid receptor 1	Mus musculus	115-120
24134844-5	2013	3T3 cells treated with hydrogen peroxide and DMNQ showed elevated expression levels of the Lpar3 gene, but not the Lpar1 and Lpar2 genes.	2,3-dimethoxy-1,4-naphthoquinone	45-49	lysophosphatidic acid receptor 2	Mus musculus	125-130
24134844-8	2013	These results suggest that LPA signaling via LPA1 inhibits the cell motile activities stimulated by hydrogen peroxide and DMNQ in 3T3 cells.	2,3-dimethoxy-1,4-naphthoquinone	122-126	lysophosphatidic acid receptor 1	Mus musculus	45-49
21354197-11	2011	The toxicity in neurons and astrocytes of agents known to cause oxidative stress (DMNQ and H(2)O(2)) was higher in cells from PON2(-/-) mice than in the same cells from wild-type mice, despite similar glutathione levels.	2,3-dimethoxy-1,4-naphthoquinone	82-86	paraoxonase 2	Mus musculus	126-130
21145826-8	2011	Moreover, menadione or 2,3-dimethoxy-1,4-naphthoquinone, which generate intracellular superoxide anion or hydrogen peroxide, respectively, induced ERK1/2 and JNK1/2 activation and migration.	2,3-dimethoxy-1,4-naphthoquinone	23-55	mitogen-activated protein kinase 3	Homo sapiens	147-153
21145826-8	2011	Moreover, menadione or 2,3-dimethoxy-1,4-naphthoquinone, which generate intracellular superoxide anion or hydrogen peroxide, respectively, induced ERK1/2 and JNK1/2 activation and migration.	2,3-dimethoxy-1,4-naphthoquinone	23-55	mitogen-activated protein kinase 8	Homo sapiens	158-162
17942907-5	2007	Mgat5-/- tumor cells were comparatively hypersensitive to the ROS inducer 2,3-dimethoxy-1,4-naphthoquinone, hyposensitive to tyrosine kinase inhibitors, to Golgi disruption by brefeldin A, and to mitotic arrest by colcemid, hydroxyurea, and camptothecin.	2,3-dimethoxy-1,4-naphthoquinone	74-106	mannoside acetylglucosaminyltransferase 5	Mus musculus	0-5
20803752-5	2011	When DMNQ was administered intraperitoneally, the activities of serum alanine aminotransferase and aspartate aminotransferase were found to increase in a dose-dependent manner, indicating that hepatotoxicity was induced by treatment with DMNQ.	2,3-dimethoxy-1,4-naphthoquinone	5-9	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	99-125
20803752-5	2011	When DMNQ was administered intraperitoneally, the activities of serum alanine aminotransferase and aspartate aminotransferase were found to increase in a dose-dependent manner, indicating that hepatotoxicity was induced by treatment with DMNQ.	2,3-dimethoxy-1,4-naphthoquinone	238-242	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	99-125
19932748-1	2010	2,3-Dimethoxy 1,4-naphthoquinone (DMNQ), which redox cycles via two-electron reduction, mediates reduction of the cell-impermeative tetrazolium dye WST-1 in kidney epithelial cells (MDCK), which express high levels of NQO1, but not in HL60 or CHO cells, which are NQO1 deficient.	2,3-dimethoxy-1,4-naphthoquinone	0-32	NAD(P)H quinone dehydrogenase 1	Homo sapiens	218-222
19932748-1	2010	2,3-Dimethoxy 1,4-naphthoquinone (DMNQ), which redox cycles via two-electron reduction, mediates reduction of the cell-impermeative tetrazolium dye WST-1 in kidney epithelial cells (MDCK), which express high levels of NQO1, but not in HL60 or CHO cells, which are NQO1 deficient.	2,3-dimethoxy-1,4-naphthoquinone	0-32	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	264-268
19932748-1	2010	2,3-Dimethoxy 1,4-naphthoquinone (DMNQ), which redox cycles via two-electron reduction, mediates reduction of the cell-impermeative tetrazolium dye WST-1 in kidney epithelial cells (MDCK), which express high levels of NQO1, but not in HL60 or CHO cells, which are NQO1 deficient.	2,3-dimethoxy-1,4-naphthoquinone	34-38	NAD(P)H quinone dehydrogenase 1	Homo sapiens	218-222
19932748-1	2010	2,3-Dimethoxy 1,4-naphthoquinone (DMNQ), which redox cycles via two-electron reduction, mediates reduction of the cell-impermeative tetrazolium dye WST-1 in kidney epithelial cells (MDCK), which express high levels of NQO1, but not in HL60 or CHO cells, which are NQO1 deficient.	2,3-dimethoxy-1,4-naphthoquinone	34-38	NAD(P)H dehydrogenase [quinone] 1	Cricetulus griseus	264-268
19932748-2	2010	DMNQ-dependent WST-1 reduction by MDCK cells was strongly inhibited by low concentrations of the NQO1 inhibitor dicoumarol and was also inhibited by diphenyleneiodonium, capsaicin, and superoxide dismutase (SOD), but not by the uncoupler FCCP or the complex IV inhibitor cyanide.	2,3-dimethoxy-1,4-naphthoquinone	0-4	NAD(P)H quinone dehydrogenase 1	Canis lupus familiaris	97-101
19932748-3	2010	This suggests that DMNQ-dependent WST-1 reduction by MDCK cells is catalyzed by NQO1 via redox cycling and plasma membrane electron transport (PMET).	2,3-dimethoxy-1,4-naphthoquinone	19-23	NAD(P)H quinone dehydrogenase 1	Canis lupus familiaris	80-84
19932748-5	2010	Exposure of MDCK cells to DMNQ for 48 h caused cellular toxicity that was extensively reversed by co-incubation with dicoumarol or exogenous SOD, catalase, or N-acetylcysteine.	2,3-dimethoxy-1,4-naphthoquinone	26-30	catalase	Canis lupus familiaris	146-154
19932748-7	2010	In conclusion, we have developed a simple real-time cellular assay for NQO1 and show that PMET plays a significant role in DMNQ redox cycling via NQO1, leading to cellular toxicity in cells with high NQO1 levels.	2,3-dimethoxy-1,4-naphthoquinone	123-127	NAD(P)H quinone dehydrogenase 1	Canis lupus familiaris	71-75
19932748-7	2010	In conclusion, we have developed a simple real-time cellular assay for NQO1 and show that PMET plays a significant role in DMNQ redox cycling via NQO1, leading to cellular toxicity in cells with high NQO1 levels.	2,3-dimethoxy-1,4-naphthoquinone	123-127	NAD(P)H quinone dehydrogenase 1	Canis lupus familiaris	146-150
19932748-7	2010	In conclusion, we have developed a simple real-time cellular assay for NQO1 and show that PMET plays a significant role in DMNQ redox cycling via NQO1, leading to cellular toxicity in cells with high NQO1 levels.	2,3-dimethoxy-1,4-naphthoquinone	123-127	NAD(P)H quinone dehydrogenase 1	Canis lupus familiaris	146-150
19524604-7	2009	Exposure of astrocytes to two oxidants, H2O2 and DMNQ, similarly impaired their neuritogenic action, and led to a decreased expression of fibronectin.	2,3-dimethoxy-1,4-naphthoquinone	49-53	fibronectin 1	Rattus norvegicus	138-149
18540044-7	2008	DMNQ increased mitochondrial ROS production, caspase-3/7 activity, DNA fragmentation, and decreased mitochondrial transmembrane potential in VSMC while decreasing PP1cgamma1 activity and expression.	2,3-dimethoxy-1,4-naphthoquinone	0-4	caspase 3	Homo sapiens	45-54
18540044-9	2008	PP1cgamma1 overexpression abrogated DMNQ-induced JNK1 activity, p53 Ser(15) phosphorylation, and Bax expression and protected VSMC against DMNQ-induced apoptosis.	2,3-dimethoxy-1,4-naphthoquinone	36-40	mitogen-activated protein kinase 8	Homo sapiens	49-53
18540044-9	2008	PP1cgamma1 overexpression abrogated DMNQ-induced JNK1 activity, p53 Ser(15) phosphorylation, and Bax expression and protected VSMC against DMNQ-induced apoptosis.	2,3-dimethoxy-1,4-naphthoquinone	36-40	tumor protein p53	Homo sapiens	64-67
18540044-9	2008	PP1cgamma1 overexpression abrogated DMNQ-induced JNK1 activity, p53 Ser(15) phosphorylation, and Bax expression and protected VSMC against DMNQ-induced apoptosis.	2,3-dimethoxy-1,4-naphthoquinone	36-40	BCL2 associated X, apoptosis regulator	Homo sapiens	97-100
18540044-10	2008	In addition, PP1cgamma1 overexpression attenuated DMNQ-induced caspase-3/7 activation and DNA fragmentation.	2,3-dimethoxy-1,4-naphthoquinone	50-54	caspase 3	Homo sapiens	63-72
18540044-11	2008	Inhibition of p53 protein expression using small interfering RNA abrogated DMNQ-induced Bax expression and significantly attenuated VSMC apoptosis.	2,3-dimethoxy-1,4-naphthoquinone	75-79	tumor protein p53	Homo sapiens	14-17
18540044-11	2008	Inhibition of p53 protein expression using small interfering RNA abrogated DMNQ-induced Bax expression and significantly attenuated VSMC apoptosis.	2,3-dimethoxy-1,4-naphthoquinone	75-79	BCL2 associated X, apoptosis regulator	Homo sapiens	88-91
18181021-5	2008	Following DMNQ exposure cells exhibited apoptotic hallmarks such as Bax oligomerization and activation, cytochrome c release, caspase activation and chromatin condensation.	2,3-dimethoxy-1,4-naphthoquinone	10-14	BCL2 associated X, apoptosis regulator	Rattus norvegicus	68-71
18181021-8	2008	Overall, our results strongly suggest that DMNQ-induced oxidative stress causes p53 accumulation and consequently caspase-2 activation, which in turn initiates apoptotic cell death via the mitochondria-mediated caspase-dependent pathway in NSCs.	2,3-dimethoxy-1,4-naphthoquinone	43-47	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	80-83
18181021-8	2008	Overall, our results strongly suggest that DMNQ-induced oxidative stress causes p53 accumulation and consequently caspase-2 activation, which in turn initiates apoptotic cell death via the mitochondria-mediated caspase-dependent pathway in NSCs.	2,3-dimethoxy-1,4-naphthoquinone	43-47	caspase 2	Rattus norvegicus	114-123
19841000-9	2009	DMNQ significantly decreased all categories of PPase activity at 10 and 100 microm and reduced PTP at 1 microm.	2,3-dimethoxy-1,4-naphthoquinone	0-4	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	95-98
19734119-7	2008	Treatment with DMNQ, MNQ and to a lesser extent BQ inhibited cell proliferation as determined by MTT reduction at 48 h. The effects of BQ and MNQ were reversed by NAC through covalent bonding to BQ and MNQ, but not DMNQ.	2,3-dimethoxy-1,4-naphthoquinone	15-19	NLR family, pyrin domain containing 1A	Mus musculus	163-166
19734119-7	2008	Treatment with DMNQ, MNQ and to a lesser extent BQ inhibited cell proliferation as determined by MTT reduction at 48 h. The effects of BQ and MNQ were reversed by NAC through covalent bonding to BQ and MNQ, but not DMNQ.	2,3-dimethoxy-1,4-naphthoquinone	215-219	NLR family, pyrin domain containing 1A	Mus musculus	163-166
17989922-4	2007	A prerequisite for O(2)(-) in combination with NO to destabilize HIF-1alpha was corroborated in RCC4-rho0 cells, when the redox cycler 2,3-dimethoxy-1,4-naphthoquinone was used as a source of superoxide.	2,3-dimethoxy-1,4-naphthoquinone	135-167	hypoxia inducible factor 1 subunit alpha	Homo sapiens	65-75
17989922-4	2007	A prerequisite for O(2)(-) in combination with NO to destabilize HIF-1alpha was corroborated in RCC4-rho0 cells, when the redox cycler 2,3-dimethoxy-1,4-naphthoquinone was used as a source of superoxide.	2,3-dimethoxy-1,4-naphthoquinone	135-167	solute carrier family 49 member 4	Homo sapiens	96-100
17404012-7	2007	Western blotting has revealed that DMNQ S-64 effectively activates the expression of caspase 8, 9, and 3, cleaves poly (ADP-ribose) polymerase, and increases the ratio of Bax/Bcl-2.	2,3-dimethoxy-1,4-naphthoquinone	35-39	caspase 8	Homo sapiens	85-104
17404012-7	2007	Western blotting has revealed that DMNQ S-64 effectively activates the expression of caspase 8, 9, and 3, cleaves poly (ADP-ribose) polymerase, and increases the ratio of Bax/Bcl-2.	2,3-dimethoxy-1,4-naphthoquinone	35-39	BCL2 associated X, apoptosis regulator	Homo sapiens	171-174
17404012-7	2007	Western blotting has revealed that DMNQ S-64 effectively activates the expression of caspase 8, 9, and 3, cleaves poly (ADP-ribose) polymerase, and increases the ratio of Bax/Bcl-2.	2,3-dimethoxy-1,4-naphthoquinone	35-39	BCL2 apoptosis regulator	Homo sapiens	175-180
17404012-8	2007	Furthermore, cytochrome c was released in a concentration-dependent manner by DMNQ S-64.	2,3-dimethoxy-1,4-naphthoquinone	78-82	cytochrome c, somatic	Homo sapiens	13-25
17404012-9	2007	Similarly, DMNQ S-64 significantly increased caspase 3 activity by enzyme-linked immunosorbent assay (ELISA).	2,3-dimethoxy-1,4-naphthoquinone	11-15	caspase 3	Homo sapiens	45-54
17404012-11	2007	Taken together, DMNQ S-64 may exhibit cytotoxicity against A549 cells via caspase activation and COX-2 inhibition.	2,3-dimethoxy-1,4-naphthoquinone	16-20	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102
16430935-0	2006	Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition.	2,3-dimethoxy-1,4-naphthoquinone	15-19	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	51-66
16430935-5	2006	Pretreatment with cytochrome P450 inhibitors, such as SKF-525A (SKF), ketoconazole and 2-methy-1,2-di-3-pyridyl-1-propanone, enhanced the hepatocyte toxicity induced by DMNQ but did not affect BQ-induced hepatocyte toxicity.	2,3-dimethoxy-1,4-naphthoquinone	169-173	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	18-33
16430935-7	2006	In addition, NADPH oxidation in microsomes was increased by treatment with DMNQ and further augmented by pretreatment with SKF, and a NADPH cytochrome P450 reductase inhibitor, diphenyleneiodonium chloride completely suppressed NADPH oxidations increased by treatment with either DMNQ- or DMNQ + SKF.	2,3-dimethoxy-1,4-naphthoquinone	75-79	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-155
16430935-7	2006	In addition, NADPH oxidation in microsomes was increased by treatment with DMNQ and further augmented by pretreatment with SKF, and a NADPH cytochrome P450 reductase inhibitor, diphenyleneiodonium chloride completely suppressed NADPH oxidations increased by treatment with either DMNQ- or DMNQ + SKF.	2,3-dimethoxy-1,4-naphthoquinone	280-284	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-155
16430935-7	2006	In addition, NADPH oxidation in microsomes was increased by treatment with DMNQ and further augmented by pretreatment with SKF, and a NADPH cytochrome P450 reductase inhibitor, diphenyleneiodonium chloride completely suppressed NADPH oxidations increased by treatment with either DMNQ- or DMNQ + SKF.	2,3-dimethoxy-1,4-naphthoquinone	280-284	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	140-155
15893420-4	2006	DMNQ S-52 increased Annexin V positive cell population in a concentration-dependent manner.	2,3-dimethoxy-1,4-naphthoquinone	0-4	annexin A5	Mus musculus	20-29
16631533-8	2006	Treatment of A549, HEK293, HepG2, and COS cells with DMNQ resulted in a concentration-dependent raise in ROS which correlated with HIF-1alpha accumulation.	2,3-dimethoxy-1,4-naphthoquinone	53-57	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
16631533-10	2006	When HIF-1alpha is stabilized by NO, low concentrations of DMNQ (<1 microM) revealed no effect, intermediate concentrations of 1 to 40 microM DMNQ attenuated HIF-1alpha accumulation and higher concentrations of DMNQ promoted HIF-1alpha stability.	2,3-dimethoxy-1,4-naphthoquinone	145-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
16631533-10	2006	When HIF-1alpha is stabilized by NO, low concentrations of DMNQ (<1 microM) revealed no effect, intermediate concentrations of 1 to 40 microM DMNQ attenuated HIF-1alpha accumulation and higher concentrations of DMNQ promoted HIF-1alpha stability.	2,3-dimethoxy-1,4-naphthoquinone	145-149	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
16493032-3	2006	CD4+ T cells were stimulated with anti-CD3 and anti-CD28 mAb in the presence or absence of oxidative stress as supplied by 2,3-dimethoxy-1,4-naphthoquinone (DMNQ), which generates a low level of superoxide anion.	2,3-dimethoxy-1,4-naphthoquinone	123-155	CD28 molecule	Homo sapiens	52-56
16493032-3	2006	CD4+ T cells were stimulated with anti-CD3 and anti-CD28 mAb in the presence or absence of oxidative stress as supplied by 2,3-dimethoxy-1,4-naphthoquinone (DMNQ), which generates a low level of superoxide anion.	2,3-dimethoxy-1,4-naphthoquinone	157-161	CD28 molecule	Homo sapiens	52-56
16493032-7	2006	Cells stimulated in the continuous presence of 5 microM DMNQ, displayed a marked up-regulation in Th2 cytokines, including IL-4, IL-5, and IL-13, but not the Th1 cytokine IFN-gamma.	2,3-dimethoxy-1,4-naphthoquinone	56-60	interleukin 4	Homo sapiens	123-127
16493032-7	2006	Cells stimulated in the continuous presence of 5 microM DMNQ, displayed a marked up-regulation in Th2 cytokines, including IL-4, IL-5, and IL-13, but not the Th1 cytokine IFN-gamma.	2,3-dimethoxy-1,4-naphthoquinone	56-60	interleukin 5	Homo sapiens	129-133
16493032-7	2006	Cells stimulated in the continuous presence of 5 microM DMNQ, displayed a marked up-regulation in Th2 cytokines, including IL-4, IL-5, and IL-13, but not the Th1 cytokine IFN-gamma.	2,3-dimethoxy-1,4-naphthoquinone	56-60	interleukin 13	Homo sapiens	139-144
16493032-7	2006	Cells stimulated in the continuous presence of 5 microM DMNQ, displayed a marked up-regulation in Th2 cytokines, including IL-4, IL-5, and IL-13, but not the Th1 cytokine IFN-gamma.	2,3-dimethoxy-1,4-naphthoquinone	56-60	interferon gamma	Homo sapiens	171-180
16493032-9	2006	Long-term exposure of T cells to DMNQ resulted in growth of cells expressing CCR4, and a decrease in cells expressing CXCR3, indicating phenotypic conversion to Th2 cells.	2,3-dimethoxy-1,4-naphthoquinone	33-37	C-C motif chemokine receptor 4	Homo sapiens	77-81
16493032-9	2006	Long-term exposure of T cells to DMNQ resulted in growth of cells expressing CCR4, and a decrease in cells expressing CXCR3, indicating phenotypic conversion to Th2 cells.	2,3-dimethoxy-1,4-naphthoquinone	33-37	C-X-C motif chemokine receptor 3	Homo sapiens	118-123
12040405-5	2001	Catalase reversed the effect of DMNQ on NB4 and U937 cells.	2,3-dimethoxy-1,4-naphthoquinone	32-36	catalase	Homo sapiens	0-8
11815678-4	2002	Incubation of follicles with DMNQ or menadione inhibited iodine organification (a step of thyroid hormone formation) and its catalytic enzyme, thyroid peroxidase (TPO).	2,3-dimethoxy-1,4-naphthoquinone	29-33	thyroid peroxidase	Homo sapiens	143-161
11815678-4	2002	Incubation of follicles with DMNQ or menadione inhibited iodine organification (a step of thyroid hormone formation) and its catalytic enzyme, thyroid peroxidase (TPO).	2,3-dimethoxy-1,4-naphthoquinone	29-33	thyroid peroxidase	Homo sapiens	163-166
12015080-4	2002	Catalase could reverse this effect of DMNQ.	2,3-dimethoxy-1,4-naphthoquinone	38-42	catalase	Homo sapiens	0-8
11759170-1	2001	6-(1-Acyloxyalkyl)-5,8-dimethoxy-1,4-naphthoquinone (DMNQ; 5,8-dimethoxy-1,4-naphthoquinone) derivatives were synthesized and examined for their inhibitory effect on DNA topoisomerase-I (Topo I) and their antiproliferative activity against L1210 cells.	2,3-dimethoxy-1,4-naphthoquinone	53-57	topoisomerase (DNA) I	Mus musculus	166-185
11697195-7	2001	DT-diaphorase and SOD strongly inhibited redox cycling by 2,3-dimethyl- and 2,3-dimethoxy-1,4-naphthoquinone, but not that of 2-hydroxy-, 5-hydroxy- or 2-amino-1,4-naphthoquinone.	2,3-dimethoxy-1,4-naphthoquinone	76-108	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-13
16103692-12	2005	The reactive oxygen species (ROS) donor 2,3-dimethoxy-1,4-naphthoquinone induced MMP-1 secretion and enhanced ANG-II-stimulated MMP-1 expression.	2,3-dimethoxy-1,4-naphthoquinone	40-72	matrix metallopeptidase 1	Homo sapiens	81-86
16103692-12	2005	The reactive oxygen species (ROS) donor 2,3-dimethoxy-1,4-naphthoquinone induced MMP-1 secretion and enhanced ANG-II-stimulated MMP-1 expression.	2,3-dimethoxy-1,4-naphthoquinone	40-72	matrix metallopeptidase 1	Homo sapiens	128-133
14672918-9	2004	Transfection of A549 cells with a dominant active MKK3 plasmid (MKK3[Glu]) partially inhibited cytolysis resulting from DMNQ, whereas the inactive MKK3 plasmid (MKK3[Ala]) had less evident protective effects.	2,3-dimethoxy-1,4-naphthoquinone	120-124	mitogen-activated protein kinase kinase 3	Homo sapiens	50-54
14672918-9	2004	Transfection of A549 cells with a dominant active MKK3 plasmid (MKK3[Glu]) partially inhibited cytolysis resulting from DMNQ, whereas the inactive MKK3 plasmid (MKK3[Ala]) had less evident protective effects.	2,3-dimethoxy-1,4-naphthoquinone	120-124	mitogen-activated protein kinase kinase 3	Homo sapiens	64-68
14672918-9	2004	Transfection of A549 cells with a dominant active MKK3 plasmid (MKK3[Glu]) partially inhibited cytolysis resulting from DMNQ, whereas the inactive MKK3 plasmid (MKK3[Ala]) had less evident protective effects.	2,3-dimethoxy-1,4-naphthoquinone	120-124	mitogen-activated protein kinase kinase 3	Homo sapiens	64-68
14672918-9	2004	Transfection of A549 cells with a dominant active MKK3 plasmid (MKK3[Glu]) partially inhibited cytolysis resulting from DMNQ, whereas the inactive MKK3 plasmid (MKK3[Ala]) had less evident protective effects.	2,3-dimethoxy-1,4-naphthoquinone	120-124	mitogen-activated protein kinase kinase 3	Homo sapiens	64-68
12874275-8	2003	In summary, EGFR-dependent signaling was mediated by protein-tyrosine phosphatase inactivation (menadione), GSH depletion (BQ), and redox-cycling (DMNQ), funneling into the same signaling pathway.	2,3-dimethoxy-1,4-naphthoquinone	147-151	epidermal growth factor receptor	Rattus norvegicus	12-16
9813007-3	1998	We report here that like gamma-GCSh, the expression of MRP1 can be induced in cultured cells treated with pro-oxidants such as tert-butylhydroquinone, 2,3-dimethoxy-1, 4-naphthoquinone, and menadione.	2,3-dimethoxy-1,4-naphthoquinone	151-184	ATP binding cassette subfamily C member 1	Homo sapiens	55-59
10453032-4	1999	Preactivation of RAW 264.7 cells with a nontoxic dose of the redox cycler 2,3-dimethoxy-1,4-naphthoquinone (5 microM) for 15 h attenuated S-nitrosoglutathione (1 mM)-initiated apoptotic cell death and averted accumulation of the tumor suppressor p53, which is indicative for macrophage apoptosis.	2,3-dimethoxy-1,4-naphthoquinone	74-106	transformation related protein 53, pseudogene	Mus musculus	246-249
9530167-4	1998	It was found that DMNQ increased GGT mRNA content by increasing transcription, as measured by nuclear run-on.	2,3-dimethoxy-1,4-naphthoquinone	18-22	gamma-glutamyltransferase 1	Rattus norvegicus	33-36
9755854-1	1998	Exposure of mesangial cells to superoxide, generated by the hypoxanthine/xanthine oxidase system or by the redox cycler 2,3-dimethoxy-1,4-naphthoquinone caused a concentration-dependent amplification of interleukin (IL)-1beta-stimulated nitrite production.	2,3-dimethoxy-1,4-naphthoquinone	120-152	interleukin 1 beta	Rattus norvegicus	203-225
9544795-8	1998	In contrast, heme oxygenase-1 expression remained elevated under conditions of GSNO/DMNQ coadministration.	2,3-dimethoxy-1,4-naphthoquinone	84-88	heme oxygenase 1	Rattus norvegicus	13-29
9185621-7	1997	Nonetheless, the present study found that the steady-state mRNA level and the transcription rate of the GCS regulatory subunit also increased under DMNQ-induced oxidative stress.	2,3-dimethoxy-1,4-naphthoquinone	148-152	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	104-107
8393647-0	1993	Orthovanadate and 2,3-dimethoxy-1,4-naphthoquinone augment growth factor-induced cell proliferation and c-fos gene expression in 3T3-L1 cells.	2,3-dimethoxy-1,4-naphthoquinone	18-50	FBJ osteosarcoma oncogene	Mus musculus	104-109
8393647-8	1993	Striking similarity was observed between VO and 2,3-dimethoxy-1,4-naphthoquinone (DMNQ) in PI 3-kinase activation, c-fos proto-oncogene expression, and DNA synthesis, key events associated with cell growth.	2,3-dimethoxy-1,4-naphthoquinone	48-80	FBJ osteosarcoma oncogene	Mus musculus	115-120
8393647-8	1993	Striking similarity was observed between VO and 2,3-dimethoxy-1,4-naphthoquinone (DMNQ) in PI 3-kinase activation, c-fos proto-oncogene expression, and DNA synthesis, key events associated with cell growth.	2,3-dimethoxy-1,4-naphthoquinone	82-86	FBJ osteosarcoma oncogene	Mus musculus	115-120
8103030-4	1993	DMNQ (0 to 150 microM) caused a dose-dependent decrease of intracellular GSH and adenosine 5"-triphosphate (ATP) in both control and 3T3-GGT cells.	2,3-dimethoxy-1,4-naphthoquinone	0-4	inactive glutathione hydrolase 2	Homo sapiens	137-140
8103030-6	1993	Administration of GSH helped to maintain intracellular GSH and supported resistance to ATP depletion caused by DMNQ in 3T3-GGT cells but not in control cells.	2,3-dimethoxy-1,4-naphthoquinone	111-115	inactive glutathione hydrolase 2	Homo sapiens	123-126
8103030-8	1993	Our results suggest that GGT-dependent breakdown of extracellular GSH for subsequent intracellular resynthesis helped to maintain cellular GSH levels and increased cellular resistance against DMNQ-induced oxidative injury.	2,3-dimethoxy-1,4-naphthoquinone	192-196	inactive glutathione hydrolase 2	Homo sapiens	25-28
7763299-5	1995	The rate of NAD+ deletion induced by tert-butyl hydroperoxide (500 microM) and 2,3-dimethoxy-1,4-naphthoquinone (50 microM) was reduced by preincubating the hepatocytes for 1 hr with either 3-aminobenzamide (20 mM), nicotinamide (10 mM) or theophylline (7.5 mM), potent inhibitors of poly(ADP-ribose)polymerase.	2,3-dimethoxy-1,4-naphthoquinone	79-111	poly (ADP-ribose) polymerase 1	Rattus norvegicus	284-310
7982974-3	1994	Following the exposure of RINm5F cells to 10 microM DMNQ, ornithine decarboxylase activity and polyamine biosynthesis increased.	2,3-dimethoxy-1,4-naphthoquinone	52-56	ornithine decarboxylase 1	Rattus norvegicus	58-81
7982974-5	1994	Conversely, exposure to 30 microM DMNQ for 3 h resulted in the inhibition of ornithine decarboxylase, intracellular polyamine depletion, and apoptotic cell killing.	2,3-dimethoxy-1,4-naphthoquinone	34-38	ornithine decarboxylase 1	Rattus norvegicus	77-100
8103030-0	1993	Extracellular glutathione and gamma-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone.	2,3-dimethoxy-1,4-naphthoquinone	91-123	inactive glutathione hydrolase 2	Homo sapiens	30-59