PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32182321-2	2020	Based on emerging structure-activity relationships we design simple alkyl 6-O-acyl-beta-d-glucosides that are effective agonists of Mincle and signal with potency on par with the prototypical ligand trehalose dimycolate.	Cord Factors	199-219	C-type lectin domain family 4 member E	Homo sapiens	132-138
3167861-2	1988	The monoclonal antibodies MK2-34 and MK1-16 (both IgM), which specifically detect N-glycolyl GM2 and N-acetyl GM2, respectively, were generated by immunizing mice with liposomes containing monophosphoryl lipid A, trehalose dimycolate, and the antigenic ganglioside.	Cord Factors	213-233	kallikrein 1-related peptidase b1	Mus musculus	37-43
6806381-0	1982	Identification of the physiologically active state of the mycobacterial glycolipid trehalose 6,6"-dimycolate and the role of fibrinogen in the biologic activities of trehalose 6,6"-dimycolate monolayers.	Cord Factors	166-191	fibrinogen beta chain	Homo sapiens	125-135
2804469-3	1989	Anti-tumor necrosis factor (TNF) blocked the cytotoxicity of trehalose dimycolate macrophage supernatant.	Cord Factors	61-81	tumor necrosis factor	Mus musculus	0-26
2804469-3	1989	Anti-tumor necrosis factor (TNF) blocked the cytotoxicity of trehalose dimycolate macrophage supernatant.	Cord Factors	61-81	tumor necrosis factor	Mus musculus	28-31
2804469-4	1989	Therefore the antitumor activity of trehalose dimycolate can be attributed to TNF released in the in vitro assay.	Cord Factors	36-56	tumor necrosis factor	Mus musculus	78-81
30308157-0	2018	Cyclopropane Modification of Trehalose Dimycolate Drives Granuloma Angiogenesis and Mycobacterial Growth through Vegf Signaling.	Cord Factors	29-49	vascular endothelial growth factor Aa	Danio rerio	113-117
25884549-1	2015	Mincle, the macrophage-inducible C-type lectin also known as CLEC-4E, binds to the mycobacterial glycolipid trehalose dimycolate and initiates a signaling cascade by serving as a receptor for Mycobacterium tuberculosis and other pathogenic mycobacterial species.	Cord Factors	108-128	C-type lectin domain family 4 member E	Homo sapiens	0-6
29781274-1	2018	The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor that recognizes trehalose dimycolate (TDM), and trehalose dibehenate (TDB) and related trehalose diesters, and thus represents a promising target for the development of vaccine adjuvants based on the trehalose glycolipid scaffold.	Cord Factors	98-118	C-type lectin domain family 4 member E	Homo sapiens	4-38
29781274-1	2018	The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor that recognizes trehalose dimycolate (TDM), and trehalose dibehenate (TDB) and related trehalose diesters, and thus represents a promising target for the development of vaccine adjuvants based on the trehalose glycolipid scaffold.	Cord Factors	98-118	C-type lectin domain family 4 member E	Homo sapiens	40-46
29048873-7	2017	Receptors with signaling capability interact with two distinct sets of mycobacterial glycans: targets for dectin-2 overlap with ligands for the mannose-binding endocytic receptors, while mincle binds exclusively to trehalose-containing structures such as trehalose dimycolate.	Cord Factors	255-275	C-type lectin domain containing 6A	Homo sapiens	106-114
28393919-1	2017	Macrophage-inducible C-type lectin (Mincle) interacts with the gamma-subunit of high-affinity IgE receptor (FcepsilonRIgamma) and activates Syk by recognizing its specific ligand, trehalose-6,6"-dimycolate, a glycolipid produced by Mycobacterium tuberculosis.	Cord Factors	180-205	C-type lectin domain family 4, member E	Rattus norvegicus	36-42
28393919-1	2017	Macrophage-inducible C-type lectin (Mincle) interacts with the gamma-subunit of high-affinity IgE receptor (FcepsilonRIgamma) and activates Syk by recognizing its specific ligand, trehalose-6,6"-dimycolate, a glycolipid produced by Mycobacterium tuberculosis.	Cord Factors	180-205	Fc epsilon receptor Ig	Rattus norvegicus	108-124
28393919-1	2017	Macrophage-inducible C-type lectin (Mincle) interacts with the gamma-subunit of high-affinity IgE receptor (FcepsilonRIgamma) and activates Syk by recognizing its specific ligand, trehalose-6,6"-dimycolate, a glycolipid produced by Mycobacterium tuberculosis.	Cord Factors	180-205	spleen associated tyrosine kinase	Rattus norvegicus	140-143
26558717-2	2016	Like Mincle, Clec4d recognizes mycobacterial cord factor, trehalose dimycolate, and we recently demonstrated its key role in anti-mycobacterial immunity in mouse and man.	Cord Factors	58-78	C-type lectin domain family 4, member d	Mus musculus	13-19
27630197-4	2016	RESULTS:  Alveolar macrophages from diabetic mice had reduced expression of CD14 and macrophage receptor with collagenous structure (MARCO), which recognize the bacterial cell wall component trehalose 6,6"-dimycolate (TDM).	Cord Factors	191-216	CD14 antigen	Mus musculus	76-80
27630197-4	2016	RESULTS:  Alveolar macrophages from diabetic mice had reduced expression of CD14 and macrophage receptor with collagenous structure (MARCO), which recognize the bacterial cell wall component trehalose 6,6"-dimycolate (TDM).	Cord Factors	191-216	macrophage receptor with collagenous structure	Mus musculus	85-131
27630197-4	2016	RESULTS:  Alveolar macrophages from diabetic mice had reduced expression of CD14 and macrophage receptor with collagenous structure (MARCO), which recognize the bacterial cell wall component trehalose 6,6"-dimycolate (TDM).	Cord Factors	191-216	macrophage receptor with collagenous structure	Mus musculus	133-138
26939595-2	2016	Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion.	Cord Factors	45-65	C-type lectin domain family 4 member E	Homo sapiens	35-41
26939595-2	2016	Herein, we show that engagement of Mincle by trehalose-dimycolate or mycobacteria promotes IL-10 production in macrophages, which causes down-regulation of IL-12p40 secretion.	Cord Factors	45-65	interleukin 10	Homo sapiens	91-96
25884549-6	2015	Sequence alignment reveals that these residues are conserved in a wide range of mammalian species, suggesting that mincle has a conserved function in binding ligands that may include endogenous mammalian glycans or pathogen glycans in addition to trehalose dimycolate.	Cord Factors	247-267	C-type lectin domain family 4 member E	Homo sapiens	115-121
25028392-0	2014	Defining the conformation of human mincle that interacts with mycobacterial trehalose dimycolate.	Cord Factors	76-96	C-type lectin domain family 4 member E	Homo sapiens	35-41
25332121-1	2015	The macrophage-inducible C-type lectin Mincle has recently been identified to be a pattern recognition receptor sensing mycobacterial infection via recognition of the mycobacterial cell wall component trehalose-6",6-dimycolate (TDM).	Cord Factors	201-226	C-type lectin domain family 4, member e	Mus musculus	39-45
25028392-1	2014	Trehalose dimycolate, an unusual glycolipid in the outer membrane of Mycobacterium tuberculosis, stimulates macrophages by binding to the macrophage receptor mincle.	Cord Factors	0-20	C-type lectin domain family 4 member E	Homo sapiens	158-164
25028392-3	2014	The mechanism of trehalose dimycolate binding to the C-type carbohydrate-recognition domain in human mincle has been investigated using a series of synthetic analogs of trehalose dimycolate and site-directed mutagenesis of the human protein.	Cord Factors	17-37	C-type lectin domain family 4 member E	Homo sapiens	101-107
25028392-3	2014	The mechanism of trehalose dimycolate binding to the C-type carbohydrate-recognition domain in human mincle has been investigated using a series of synthetic analogs of trehalose dimycolate and site-directed mutagenesis of the human protein.	Cord Factors	169-189	C-type lectin domain family 4 member E	Homo sapiens	101-107
25002863-3	2014	We also discuss the identification and structure-activity relationships of activating ligands, particularly trehalose dimycolate and related mycobacterial glycolipids, which have significant potential in the development of TH1/TH17 vaccination strategies.	Cord Factors	108-128	negative elongation factor complex member C/D	Homo sapiens	223-226
25202022-1	2014	Previous studies indicate that both Dectin-3 (also called MCL or Clec4d) and Mincle (also called Clec4e), two C-type lectin receptors, can recognize trehalose 6,6"-dimycolate (TDM), a cell wall component from mycobacteria, and induce potent innate immune responses.	Cord Factors	149-174	C-type lectin domain family 4, member d	Mus musculus	65-71
25202022-1	2014	Previous studies indicate that both Dectin-3 (also called MCL or Clec4d) and Mincle (also called Clec4e), two C-type lectin receptors, can recognize trehalose 6,6"-dimycolate (TDM), a cell wall component from mycobacteria, and induce potent innate immune responses.	Cord Factors	149-174	C-type lectin domain family 4, member e	Mus musculus	77-83
25202022-1	2014	Previous studies indicate that both Dectin-3 (also called MCL or Clec4d) and Mincle (also called Clec4e), two C-type lectin receptors, can recognize trehalose 6,6"-dimycolate (TDM), a cell wall component from mycobacteria, and induce potent innate immune responses.	Cord Factors	149-174	C-type lectin domain family 4, member e	Mus musculus	97-103
25156364-1	2014	Trehalose-6,6-dimycolate (TDM), the mycobacterial cord factor, and its synthetic analog Trehalose-6,6-dibehenate (TDB) bind to the C-type lectin receptors macrophage-inducible C-type lectin (Mincle) and Mcl to activate macrophages.	Cord Factors	0-24	C-type lectin domain family 4 member E	Homo sapiens	191-197
24533147-2	2014	We have previously reported that two C-type lectin receptors, Mincle (macrophage inducible C-type lectin, also called Clec4e) and MCL (macrophage C-type lectin, also called Clec4d), recognize the mycobacterial cord factor, trehalose-6,6"-dimycolate (TDM).	Cord Factors	223-248	C-type lectin domain family 4 member E	Cavia porcellus	118-124
24733387-2	2014	Examples include trehalose dimycolate (TDM), which is a major surface-exposed glycolipid of mycobacteria, that interacts with the macrophage inducible C-type lectin, Mincle, and exerts its highly potent adjuvant functions.	Cord Factors	17-37	C-type lectin domain family 4, member e	Mus musculus	130-164
24733387-2	2014	Examples include trehalose dimycolate (TDM), which is a major surface-exposed glycolipid of mycobacteria, that interacts with the macrophage inducible C-type lectin, Mincle, and exerts its highly potent adjuvant functions.	Cord Factors	17-37	C-type lectin domain family 4, member e	Mus musculus	166-172
24733387-2	2014	Examples include trehalose dimycolate (TDM), which is a major surface-exposed glycolipid of mycobacteria, that interacts with the macrophage inducible C-type lectin, Mincle, and exerts its highly potent adjuvant functions.	Cord Factors	39-42	C-type lectin domain family 4, member e	Mus musculus	130-164
24733387-2	2014	Examples include trehalose dimycolate (TDM), which is a major surface-exposed glycolipid of mycobacteria, that interacts with the macrophage inducible C-type lectin, Mincle, and exerts its highly potent adjuvant functions.	Cord Factors	39-42	C-type lectin domain family 4, member e	Mus musculus	166-172
24533147-2	2014	We have previously reported that two C-type lectin receptors, Mincle (macrophage inducible C-type lectin, also called Clec4e) and MCL (macrophage C-type lectin, also called Clec4d), recognize the mycobacterial cord factor, trehalose-6,6"-dimycolate (TDM).	Cord Factors	223-248	C-type lectin domain family 4 member D	Cavia porcellus	173-179
22963130-1	2012	We previously showed that formation of pulmonary granulomas in mice in response to a mycobacterial glycolipid, trehalose 6,6"-dimycolate (TDM) is due to the action of TNF-alpha and not of IFN-gamma.	Cord Factors	111-136	tumor necrosis factor	Mus musculus	167-176
23630357-8	2013	Moreover, we demonstrated that recognition of the mycobacterial glycolipid trehalose dimycolate (cord factor) by the C-type lectin receptor mincle partially explains this CARD9 requirement.	Cord Factors	75-95	C-type lectin domain family 4, member e	Mus musculus	140-146
23630357-8	2013	Moreover, we demonstrated that recognition of the mycobacterial glycolipid trehalose dimycolate (cord factor) by the C-type lectin receptor mincle partially explains this CARD9 requirement.	Cord Factors	75-95	caspase recruitment domain family, member 9	Mus musculus	171-176
22921586-3	2013	The mycobacterial cord factor trehalose-6,6"-dimycolate (TDM) and its synthetic adjuvant analogue trehalose-6,6"-dibehenate (TDB) rely on the C-type lectin Mincle and the signaling molecules Syk and Card9 to trigger innate immunity.	Cord Factors	30-55	spleen tyrosine kinase	Mus musculus	191-194
22921586-3	2013	The mycobacterial cord factor trehalose-6,6"-dimycolate (TDM) and its synthetic adjuvant analogue trehalose-6,6"-dibehenate (TDB) rely on the C-type lectin Mincle and the signaling molecules Syk and Card9 to trigger innate immunity.	Cord Factors	30-55	caspase recruitment domain family, member 9	Mus musculus	199-204
20875896-0	2010	Lactoferrin modulation of mycobacterial cord factor trehalose 6-6"-dimycolate induced granulomatous response.	Cord Factors	52-77	lactotransferrin	Mus musculus	0-11
22173278-0	2012	A20 and ABIN-3 possibly promote regression of trehalose 6,6"-dimycolate (TDM)-induced granuloma by interacting with an NF-kappa B signaling protein, TAK-1.	Cord Factors	46-71	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
22173278-0	2012	A20 and ABIN-3 possibly promote regression of trehalose 6,6"-dimycolate (TDM)-induced granuloma by interacting with an NF-kappa B signaling protein, TAK-1.	Cord Factors	46-71	TNFAIP3 interacting protein 3	Mus musculus	8-14
22173278-0	2012	A20 and ABIN-3 possibly promote regression of trehalose 6,6"-dimycolate (TDM)-induced granuloma by interacting with an NF-kappa B signaling protein, TAK-1.	Cord Factors	46-71	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-129
22173278-0	2012	A20 and ABIN-3 possibly promote regression of trehalose 6,6"-dimycolate (TDM)-induced granuloma by interacting with an NF-kappa B signaling protein, TAK-1.	Cord Factors	46-71	mitogen-activated protein kinase kinase kinase 7	Mus musculus	149-154
22496642-0	2012	Neutrophils Promote Mycobacterial Trehalose Dimycolate-Induced Lung Inflammation via the Mincle Pathway.	Cord Factors	34-54	C-type lectin domain family 4, member e	Mus musculus	89-95
21110061-0	2011	Histopathological features and expression profiles of cytokines, chemokines and SOCS family proteins in trehalose 6,6"-dimycolate-induced granulomatous lesions.	Cord Factors	104-129	cytokine inducible SH2-containing protein	Mus musculus	80-84
20008526-0	2009	Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle.	Cord Factors	52-72	C-type lectin domain family 4, member e	Mus musculus	91-97
17286434-0	2007	Efficient syntheses of a series of trehalose dimycolate (TDM)/trehalose dicorynomycolate (TDCM) analogues and their interleukin-6 level enhancement activity in mice sera.	Cord Factors	35-55	interleukin 6	Mus musculus	116-129
18535659-6	2008	Treatment of macrophages with trehalose dimycolate (TDM) purified from the DeltammaA4 mutant stimulated increased IL-12p40, similar to the increase observed from DeltammaA4 mutant-infected macrophages.	Cord Factors	30-50	interleukin 12b	Mus musculus	114-122
19453755-3	2009	The stronger induction of IL-12 and TNF-alpha in the presence of IFN-gamma was also observed by trehalose 6,6"-dimycolate (TDM) extracted from BCG-Japan than by TDM from BCG-Connaught, which lacks the methoxymycolate residue.	Cord Factors	96-121	interferon gamma	Mus musculus	65-74
17880727-1	2007	This study aimed to demonstrate that microspheres, used as delivery vehicle of DNA-Hsp65/TDM [plasmid DNA encoding heat shock protein 65 (Hsp65) coencapsulated with trehalose dimycolate (TDM) into PLGA microspheres], are widely spread among several organs after intramuscular administration in BALB/c mice.	Cord Factors	165-185	heat shock protein 1 (chaperonin)	Mus musculus	83-88
17286434-1	2007	We found an IL-6 level-enhancing compound during our synthetic study of trehalose-6,6"-dimycolate (1, TDM, formerly called cord factor) analogues.	Cord Factors	72-97	interleukin 6	Mus musculus	12-16
10449256-0	1999	Insufficient resistance of trehalose-6,6-dimycolate-treated T-cell receptor delta gene mutant (TCR delta-/-) mice against influenza virus infection.	Cord Factors	27-51	T cell receptor delta chain	Mus musculus	60-108
15814731-9	2005	Trehalose dimycolate, when delivered to bone marrow-derived murine macrophages, induced the greatest secretion of IL-1beta, IL-6, and TNF-alpha in vitro.	Cord Factors	0-20	interleukin 1 beta	Mus musculus	114-122
15814731-9	2005	Trehalose dimycolate, when delivered to bone marrow-derived murine macrophages, induced the greatest secretion of IL-1beta, IL-6, and TNF-alpha in vitro.	Cord Factors	0-20	interleukin 6	Mus musculus	124-128
15814731-9	2005	Trehalose dimycolate, when delivered to bone marrow-derived murine macrophages, induced the greatest secretion of IL-1beta, IL-6, and TNF-alpha in vitro.	Cord Factors	0-20	tumor necrosis factor	Mus musculus	134-143
16542375-0	2006	Interferon-gamma independent formation of pulmonary granuloma in mice by injections with trehalose dimycolate (cord factor), lipoarabinomannan and phosphatidylinositol mannosides isolated from Mycobacterium tuberculosis.	Cord Factors	89-109	interferon gamma	Mus musculus	0-16
11798467-0	2001	Dysregulated response to mycobacterial cord factor trehalose-6,6"-dimycolate in CD1D-/- mice.	Cord Factors	51-76	CD1d1 antigen	Mus musculus	80-84
10586120-0	1999	Tumor necrosis factor is required for the priming of peritoneal macrophages by trehalose dimycolate.	Cord Factors	79-99	tumor necrosis factor	Mus musculus	0-21
7509725-2	1994	In macrophages primed by interferon-gamma (IFN-gamma) or trehalose dimycolate (TDM), LPS induces NO synthase and the events associated with a high nitric oxide output: antitumor and antiparasitic activities.	Cord Factors	57-77	toll-like receptor 4	Mus musculus	85-88
7506511-0	1993	Antiviral action of trehalose dimycolate against EMC virus: role of macrophages and interferon alpha/beta.	Cord Factors	20-40	interferon alpha B	Mus musculus	84-105
1825477-3	1991	In this study, we show that (a) s.c. injection of epiglycanin emulsified in either complete Freund"s adjuvant or Ribi adjuvant containing trehalose dimycolate and monophosphoryl lipid A elicits a classical specific delayed-type hyperactivity response to TF haptens either naturally expressed on epiglycanin or as synthetic haptens conjugated to a protein carrier; (b) i.v.	Cord Factors	138-158	mucin 21	Mus musculus	50-61
1825477-3	1991	In this study, we show that (a) s.c. injection of epiglycanin emulsified in either complete Freund"s adjuvant or Ribi adjuvant containing trehalose dimycolate and monophosphoryl lipid A elicits a classical specific delayed-type hyperactivity response to TF haptens either naturally expressed on epiglycanin or as synthetic haptens conjugated to a protein carrier; (b) i.v.	Cord Factors	138-158	mucin 21	Mus musculus	295-306
32796022-2	2020	Mycobacterial cord factor trehalose-6,6-dimycolate (TDM) binds the C-type lectin receptor MINCLE and induces inflammatory gene expression.	Cord Factors	26-50	C-type lectin domain family 4, member e	Mus musculus	90-96
2144650-5	1990	PLA2 injection also enhances the CL of peritoneal cells from mice already stimulated by immunomodulators such as trehalose dimycolate (TDM), bestatin, or oncostatic drugs such as aclacinomycin (ACM).	Cord Factors	113-133	phospholipase A2, group IB, pancreas	Mus musculus	0-4
2144650-5	1990	PLA2 injection also enhances the CL of peritoneal cells from mice already stimulated by immunomodulators such as trehalose dimycolate (TDM), bestatin, or oncostatic drugs such as aclacinomycin (ACM).	Cord Factors	135-138	phospholipase A2, group IB, pancreas	Mus musculus	0-4
2322938-3	1990	Trehalose dimycolate and glucose monomycolate from N. rubra, and glucose monomycolate with C56-60 mycolic acids from Rhodococcus terrae also showed a distinctive priming activity for tumor necrosis factor (TNF), when lipopolysaccharide from Escherichia coli was administered as an eliciting agent.	Cord Factors	0-20	tumor necrosis factor	Mus musculus	206-209