PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2447954-1	1987	The anti-tumor antibiotics neocarzinostatin and bleomycin specifically oxidize deoxyribose in DNA at the C-5" and C-4" positions, respectively.	Zinostatin	27-43	complement C5	Homo sapiens	105-108
2481842-6	1989	By this assay, we first identified the formation of C-4"-hydroxy abasic sites in calf thymus DNA by neocarzinostatin.	Zinostatin	100-116	complement C4	Bos taurus	52-55
2968779-0	1988	[Targeting chemotherapy with transferrin-neocarzinostatin conjugate].	Zinostatin	41-57	transferrin	Homo sapiens	29-40
2968779-2	1988	Human diferric transferrin was conjugated with neocarzinostatin (NCS) using N-succinimidyl 3-(2-pyridyldithio)-propionate.	Zinostatin	47-63	transferrin	Homo sapiens	15-26
2968779-2	1988	Human diferric transferrin was conjugated with neocarzinostatin (NCS) using N-succinimidyl 3-(2-pyridyldithio)-propionate.	Zinostatin	65-68	transferrin	Homo sapiens	15-26
2447954-1	1987	The anti-tumor antibiotics neocarzinostatin and bleomycin specifically oxidize deoxyribose in DNA at the C-5" and C-4" positions, respectively.	Zinostatin	27-43	complement C4A (Rodgers blood group)	Homo sapiens	114-117
3016123-0	1986	[Anti-tumor effect of transferrin-neocarzinostatin conjugate which is taken up by cells with receptor medicated endocytosis].	Zinostatin	34-50	transferrin	Homo sapiens	22-33
3015036-1	1986	A new type of anticancer agent with an amphiphilic nature, poly (styrene-co-maleic acid)-conjugated neocarzinostatin [SMANCS], was dissolved in the lipid contrast medium Lipiodol [SMANCS/LPD].	Zinostatin	100-116	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	187-190
3008815-4	1986	Although superoxide dismutase inhibits the reduction of nitro blue tetrazolium and cytochrome c induced by neocarzinostatin, neither it nor catalase interferes with the action of neocarzinostatin on DNA, whether or not drug has been activated by thiol.	Zinostatin	107-123	cytochrome c, somatic	Homo sapiens	83-95
6456962-0	1981	Stimulation of DNA polymerase beta activity in permeabilized mouse P815 mast cells after neocarzinostatin treatment.	Zinostatin	89-105	polymerase (DNA directed), beta	Mus musculus	15-34
2992774-1	1985	The antitumor antibiotic neocarzinostatin (NCS), which produces single-strand breaks in mammalian cell DNA in vivo, stimulated the activity of chromatin bound enzyme, poly(ADP-ribose) polymerase in HeLa-S3 cells.	Zinostatin	25-41	poly(ADP-ribose) polymerase 1	Homo sapiens	167-194
2992774-1	1985	The antitumor antibiotic neocarzinostatin (NCS), which produces single-strand breaks in mammalian cell DNA in vivo, stimulated the activity of chromatin bound enzyme, poly(ADP-ribose) polymerase in HeLa-S3 cells.	Zinostatin	43-46	poly(ADP-ribose) polymerase 1	Homo sapiens	167-194
3160453-1	1985	A new type of anticancer agent with an amphiphilic nature, poly(styrene-co-maleic acid)-conjugated neocarzinostatin (Smancs), was dissolved in lipid contrast medium Lipiodol (Smancs/Lpd, Gelbet Co., Paris, France).	Zinostatin	99-115	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	Homo sapiens	182-185
2582408-0	1985	Endonuclease-resistant apyrimidinic sites formed by neocarzinostatin at cytosine residues in DNA: evidence for a possible role in mutagenesis.	Zinostatin	52-68	endonuclease	Escherichia coli	0-12
2582408-10	1985	The selective formation of endonuclease-resistant apyrimidinic sites at specific cytosine residues may explain the high frequency of G X C to A X T transitions in the mutational spectrum of neocarzinostatin.	Zinostatin	190-206	endonuclease	Escherichia coli	27-39
3158807-0	1985	[The role of aminopeptidase in neocarzinostatin-resistant Staphylococcus aureus].	Zinostatin	31-47	AT695_RS10745	Staphylococcus aureus	13-27
6231960-1	1983	The activation of the antitumor protein antibiotic neocarzinostatin (NCS) by the carboxyl radical CO-2, a one-electron donor obtained selectively from gamma-ray irradiation of nitrous oxide-saturated formate buffer, has been investigated in the presence and in the absence of DNA at pH 4.7 and pH 7.0.	Zinostatin	51-67	complement C2	Homo sapiens	98-102
6231960-1	1983	The activation of the antitumor protein antibiotic neocarzinostatin (NCS) by the carboxyl radical CO-2, a one-electron donor obtained selectively from gamma-ray irradiation of nitrous oxide-saturated formate buffer, has been investigated in the presence and in the absence of DNA at pH 4.7 and pH 7.0.	Zinostatin	69-72	complement C2	Homo sapiens	98-102
6227335-0	1983	Deoxyribonucleic acid damage by neocarzinostatin chromophore: strand breaks generated by selective oxidation of C-5" of deoxyribose.	Zinostatin	32-48	complement C5	Homo sapiens	112-115
2935880-1	1986	Lipophilic anionic copolymer (styrene-maleic acid; SMA) conjugates of albumin and antitumor protein neocarzinostatin (NCS) (smancs) were found to stimulate the release of H2O2 and O-2 from the peritoneal macrophages obtained from mice which had been pretreated with the heat-killed preparation of Streptococcus pyogenes (OK-432) in vivo.	Zinostatin	100-116	immunoglobulin mu binding protein 2	Mus musculus	51-54
2935880-1	1986	Lipophilic anionic copolymer (styrene-maleic acid; SMA) conjugates of albumin and antitumor protein neocarzinostatin (NCS) (smancs) were found to stimulate the release of H2O2 and O-2 from the peritoneal macrophages obtained from mice which had been pretreated with the heat-killed preparation of Streptococcus pyogenes (OK-432) in vivo.	Zinostatin	118-121	immunoglobulin mu binding protein 2	Mus musculus	51-54
2931051-0	1985	[Treatment of meningeal carcinomatosis--neocarzinostatin perfusion therapy in the CSF pathway].	Zinostatin	40-56	colony stimulating factor 2	Homo sapiens	82-85
6230671-2	1984	The region of DNA protected by Cre against nuclease attack by DNase I or neocarzinostatin is a 34-base-pair (bp) region containing two 13-bp inverted repeats separated by an 8-bp spacer region.	Zinostatin	73-89	site-specific integrase	Escherichia phage P1	31-34
6217447-0	1982	Neocarzinostatin chromophore-DNA adducts: evidence for a covalent linkage to the oxidized C-5" of deoxyribose.	Zinostatin	0-16	complement C5	Homo sapiens	90-93
23509889-6	2013	ATM protein level was low in all patients and the response to the radiomimetic agent, neocarzinostatin, was reduced.	Zinostatin	86-102	ATM serine/threonine kinase	Homo sapiens	0-3
29807321-4	2018	Moreover, NCS-induced DSBs, detected as 53BP1 foci, were more persistent in PNKP -/- HCT116 cells compared to their wild-type (WT) counterparts.	Zinostatin	10-13	tumor protein p53 binding protein 1	Homo sapiens	40-45
29807321-4	2018	Moreover, NCS-induced DSBs, detected as 53BP1 foci, were more persistent in PNKP -/- HCT116 cells compared to their wild-type (WT) counterparts.	Zinostatin	10-13	polynucleotide kinase 3'-phosphatase	Homo sapiens	76-80
29515139-3	2018	We show that treatment of MDMs with neocarzinostatin, a compound that introduces double strand breaks (DBS) in genomic DNA, results in the decrease of phosphorylated SAMHD1, activating its antiviral activity and blocking HIV-1 infection.	Zinostatin	36-52	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	166-172
29515139-7	2018	In response to Neocarzinostatin-induced DNA damage, the level of the CDK inhibitor p21cip1 increased which could account for the decrease of phosphorylated SAMHD1.	Zinostatin	15-31	cyclin dependent kinase inhibitor 1A	Homo sapiens	83-90
29515139-7	2018	In response to Neocarzinostatin-induced DNA damage, the level of the CDK inhibitor p21cip1 increased which could account for the decrease of phosphorylated SAMHD1.	Zinostatin	15-31	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1	Homo sapiens	156-162
28668853-0	2017	Neocarzinostatin, Aptamer Conjugates for Targeting EpCAM-positive Tumor Cells.	Zinostatin	0-16	epithelial cell adhesion molecule	Homo sapiens	51-56
28668853-1	2017	BACKGROUND/AIM: The aim of this study was to investigate the role of Neocarzinostatin (NCS) conjugated with epithelial cell adhesion molecule (EpCAM) aptamer in EpCAM-positive cancer cells.	Zinostatin	69-85	epithelial cell adhesion molecule	Homo sapiens	108-141
28668853-1	2017	BACKGROUND/AIM: The aim of this study was to investigate the role of Neocarzinostatin (NCS) conjugated with epithelial cell adhesion molecule (EpCAM) aptamer in EpCAM-positive cancer cells.	Zinostatin	69-85	epithelial cell adhesion molecule	Homo sapiens	143-148
28668853-1	2017	BACKGROUND/AIM: The aim of this study was to investigate the role of Neocarzinostatin (NCS) conjugated with epithelial cell adhesion molecule (EpCAM) aptamer in EpCAM-positive cancer cells.	Zinostatin	69-85	epithelial cell adhesion molecule	Homo sapiens	161-166
28668853-1	2017	BACKGROUND/AIM: The aim of this study was to investigate the role of Neocarzinostatin (NCS) conjugated with epithelial cell adhesion molecule (EpCAM) aptamer in EpCAM-positive cancer cells.	Zinostatin	87-90	epithelial cell adhesion molecule	Homo sapiens	108-141
28668853-1	2017	BACKGROUND/AIM: The aim of this study was to investigate the role of Neocarzinostatin (NCS) conjugated with epithelial cell adhesion molecule (EpCAM) aptamer in EpCAM-positive cancer cells.	Zinostatin	87-90	epithelial cell adhesion molecule	Homo sapiens	143-148
28668853-1	2017	BACKGROUND/AIM: The aim of this study was to investigate the role of Neocarzinostatin (NCS) conjugated with epithelial cell adhesion molecule (EpCAM) aptamer in EpCAM-positive cancer cells.	Zinostatin	87-90	epithelial cell adhesion molecule	Homo sapiens	161-166
28442631-6	2017	In many of the tested cell lines, we found that p53 abundance oscillated in response to ionizing radiation or the DNA-damaging chemotherapeutic neocarzinostatin and that the periodicity of the oscillations was fixed.	Zinostatin	144-160	tumor protein p53	Homo sapiens	48-51
24530422-3	2014	K562/DNR overexpressed major enzymes of NHEJ, DNA-PKcs and DNA ligase IV, and K562/DNR repaired DSB more rapidly than K562 after DNA damage by neocarzinostatin (MDR1-independent radiation-mimetic).	Zinostatin	143-159	ATP binding cassette subfamily B member 1	Homo sapiens	161-165
30113698-2	2018	Consequently, both a knockout of Artemis and a knockout/knockdown of TDP1 rendered cells sensitive to the radiomimetic agent neocarzinostatin (NCS), which induces 3"-PG-terminated DSBs.	Zinostatin	125-141	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	69-73
30113698-2	2018	Consequently, both a knockout of Artemis and a knockout/knockdown of TDP1 rendered cells sensitive to the radiomimetic agent neocarzinostatin (NCS), which induces 3"-PG-terminated DSBs.	Zinostatin	143-146	tyrosyl-DNA phosphodiesterase 1	Homo sapiens	69-73
25659035-3	2015	Here we show that in human cells exposed to ionizing radiation or genotoxic drugs etoposide and neocarzinostatin, DAXX became rapidly phosphorylated in an ATM kinase-dependent manner.	Zinostatin	96-112	death domain associated protein	Homo sapiens	114-118
23459830-4	2013	Moreover, Ing1(-/-) cells showed impaired genomic DNA repair after H2O2 and neocarzinostatin treatment and this defect was reverted by overexpression of ING1b.	Zinostatin	76-92	inhibitor of growth family member 1	Homo sapiens	10-14
22237206-2	2012	This study demonstrates that ROS induction after treatment of cells with neocarzinostatin (NCS), an ionizing radiation mimetic, is at least partly mediated by increasing histone H2AX.	Zinostatin	73-89	H2A.X variant histone	Homo sapiens	178-182
23255604-4	2013	IP6K1 knock-out MEFs show decreased viability and reduced recovery after induction of DNA damage by the replication stress inducer, hydroxyurea, or the radiomimetic antibiotic, neocarzinostatin.	Zinostatin	177-193	inositol hexaphosphate kinase 1	Mus musculus	0-5
21922195-3	2012	Synthetic lethality achieved by disrupting PARP activity in Cdk5-deficient cells was confirmed, and the Cdk5(KD) cells were also found to be sensitive to the killing effects of ionizing radiation (IR) but not methyl methanesulfonate or neocarzinostatin.	Zinostatin	236-252	cyclin dependent kinase 5	Homo sapiens	104-108
22508697-5	2012	In addition, INT6 silencing prevented sustained accumulation of ataxia telangiectasia mutated (ATM) at DNA damage sites in cells treated with gamma-radiation or the radiomimetic drug neocarzinostatin.	Zinostatin	183-199	eukaryotic translation initiation factor 3 subunit E	Homo sapiens	13-17
22508697-5	2012	In addition, INT6 silencing prevented sustained accumulation of ataxia telangiectasia mutated (ATM) at DNA damage sites in cells treated with gamma-radiation or the radiomimetic drug neocarzinostatin.	Zinostatin	183-199	ATM serine/threonine kinase	Homo sapiens	64-93
22508697-5	2012	In addition, INT6 silencing prevented sustained accumulation of ataxia telangiectasia mutated (ATM) at DNA damage sites in cells treated with gamma-radiation or the radiomimetic drug neocarzinostatin.	Zinostatin	183-199	ATM serine/threonine kinase	Homo sapiens	95-98
22237206-2	2012	This study demonstrates that ROS induction after treatment of cells with neocarzinostatin (NCS), an ionizing radiation mimetic, is at least partly mediated by increasing histone H2AX.	Zinostatin	91-94	H2A.X variant histone	Homo sapiens	178-182
22977523-4	2011	Biochemical analysis indicated that several regions of BAAT1 were responsible for the interaction with these proteins, and their binding affinity was altered after treatment with the IR mimetic, neocarzinostatin (NCS).	Zinostatin	195-211	BRCA1 associated ATM activator 1	Homo sapiens	55-60
22977523-4	2011	Biochemical analysis indicated that several regions of BAAT1 were responsible for the interaction with these proteins, and their binding affinity was altered after treatment with the IR mimetic, neocarzinostatin (NCS).	Zinostatin	213-216	BRCA1 associated ATM activator 1	Homo sapiens	55-60
20876284-6	2010	Here, we provide genetic evidence that ATM kinase activity is required to trigger 5-FU- and neocarzinostatin-dependent cFLIP(L) and cFLIP(S) down-regulation, which in turn sensitize hepatocellular carcinoma (HCC) cell lines to TRAIL.	Zinostatin	92-108	ATM serine/threonine kinase	Homo sapiens	39-42
21144835-2	2011	We investigated the roles of PP5 in the repair of ultraviolet (UV)- and neocarzinostatin (NCS)-induced DNA damage.	Zinostatin	72-88	protein phosphatase 5 catalytic subunit	Homo sapiens	29-32
20876284-6	2010	Here, we provide genetic evidence that ATM kinase activity is required to trigger 5-FU- and neocarzinostatin-dependent cFLIP(L) and cFLIP(S) down-regulation, which in turn sensitize hepatocellular carcinoma (HCC) cell lines to TRAIL.	Zinostatin	92-108	CASP8 and FADD like apoptosis regulator	Homo sapiens	119-124
20876284-6	2010	Here, we provide genetic evidence that ATM kinase activity is required to trigger 5-FU- and neocarzinostatin-dependent cFLIP(L) and cFLIP(S) down-regulation, which in turn sensitize hepatocellular carcinoma (HCC) cell lines to TRAIL.	Zinostatin	92-108	CASP8 and FADD like apoptosis regulator	Homo sapiens	132-140
20876284-6	2010	Here, we provide genetic evidence that ATM kinase activity is required to trigger 5-FU- and neocarzinostatin-dependent cFLIP(L) and cFLIP(S) down-regulation, which in turn sensitize hepatocellular carcinoma (HCC) cell lines to TRAIL.	Zinostatin	92-108	TNF superfamily member 10	Homo sapiens	227-232
20023697-2	2010	Here, we report a role of PIG3 in the activation of DNA damage checkpoints, after UV irradiation or radiomimetic drug neocarzinostatin (NCS).	Zinostatin	118-134	tumor protein p53 inducible protein 3	Homo sapiens	26-30
20421735-10	2010	SFPQ and MATR3 depletion led to abnormal accumulation of cells at the S-phase of the cell cycle following treatment with the radiomimetic chemical neocarzinostatin.	Zinostatin	147-163	splicing factor proline and glutamine rich	Homo sapiens	0-4
20421735-10	2010	SFPQ and MATR3 depletion led to abnormal accumulation of cells at the S-phase of the cell cycle following treatment with the radiomimetic chemical neocarzinostatin.	Zinostatin	147-163	matrin 3	Homo sapiens	9-14
20023697-2	2010	Here, we report a role of PIG3 in the activation of DNA damage checkpoints, after UV irradiation or radiomimetic drug neocarzinostatin (NCS).	Zinostatin	136-139	tumor protein p53 inducible protein 3	Homo sapiens	26-30
19915695-7	2009	From our data, we were able to detect differences in the phosphorylation patterns in Ser25 and Ser1778 of 53BP1 after neocarzinostatin-induced DNA damage.	Zinostatin	118-134	tumor protein p53 binding protein 1	Homo sapiens	106-111
18338171-6	2008	RESULTS: In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.9; P < 0.01).	Zinostatin	79-95	BCL2 apoptosis regulator	Homo sapiens	155-160
19176521-0	2009	Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage.	Zinostatin	60-76	protein phosphatase 5 catalytic subunit	Homo sapiens	0-21
19176521-0	2009	Protein phosphatase 5 regulates the function of 53BP1 after neocarzinostatin-induced DNA damage.	Zinostatin	60-76	tumor protein p53 binding protein 1	Homo sapiens	48-53
19176521-5	2009	This interaction further confirmed that 53BP1 interacts with PP5 in PP5-overexpressing U2OS cells, after radiomimetic agent neocarzinostatin (NCS) treatment.	Zinostatin	124-140	tumor protein p53 binding protein 1	Homo sapiens	40-45
19176521-5	2009	This interaction further confirmed that 53BP1 interacts with PP5 in PP5-overexpressing U2OS cells, after radiomimetic agent neocarzinostatin (NCS) treatment.	Zinostatin	124-140	protein phosphatase 5 catalytic subunit	Homo sapiens	61-64
19176521-5	2009	This interaction further confirmed that 53BP1 interacts with PP5 in PP5-overexpressing U2OS cells, after radiomimetic agent neocarzinostatin (NCS) treatment.	Zinostatin	124-140	protein phosphatase 5 catalytic subunit	Homo sapiens	68-71
19176521-5	2009	This interaction further confirmed that 53BP1 interacts with PP5 in PP5-overexpressing U2OS cells, after radiomimetic agent neocarzinostatin (NCS) treatment.	Zinostatin	142-145	tumor protein p53 binding protein 1	Homo sapiens	40-45
19176521-5	2009	This interaction further confirmed that 53BP1 interacts with PP5 in PP5-overexpressing U2OS cells, after radiomimetic agent neocarzinostatin (NCS) treatment.	Zinostatin	142-145	protein phosphatase 5 catalytic subunit	Homo sapiens	61-64
19176521-5	2009	This interaction further confirmed that 53BP1 interacts with PP5 in PP5-overexpressing U2OS cells, after radiomimetic agent neocarzinostatin (NCS) treatment.	Zinostatin	142-145	protein phosphatase 5 catalytic subunit	Homo sapiens	68-71
18338171-6	2008	RESULTS: In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.9; P < 0.01).	Zinostatin	79-95	caspase 3	Homo sapiens	165-174
18338171-7	2008	Neuroblastoma and brain tumor cell lines are particularly sensitive to neocarzinostatin; the sensitivity of brain tumor lines to neocarzinostatin is enhanced by transfection with an expression construct for Bcl-2 and is proportional in transfected cells to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.7).	Zinostatin	129-145	BCL2 apoptosis regulator	Homo sapiens	207-212
18338171-7	2008	Neuroblastoma and brain tumor cell lines are particularly sensitive to neocarzinostatin; the sensitivity of brain tumor lines to neocarzinostatin is enhanced by transfection with an expression construct for Bcl-2 and is proportional in transfected cells to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.7).	Zinostatin	129-145	BCL2 apoptosis regulator	Homo sapiens	297-302
18338171-7	2008	Neuroblastoma and brain tumor cell lines are particularly sensitive to neocarzinostatin; the sensitivity of brain tumor lines to neocarzinostatin is enhanced by transfection with an expression construct for Bcl-2 and is proportional in transfected cells to the product of the relative contents of Bcl-2 and caspase-3 (r (2) = 0.7).	Zinostatin	129-145	caspase 3	Homo sapiens	307-316
16170329-4	2005	Jasmonic acid and methyl jasmonate (0.25-3 mM) were each equally cytotoxic to both clones, whereas mutant p53-expressing cells were resistant to treatment with the radiomimetic agent neocarzinostatin and the chemotherapeutic agent bleomycin.	Zinostatin	183-199	tumor protein p53	Homo sapiens	106-109
16001169-0	2006	Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2.	Zinostatin	31-47	BCL2, apoptosis regulator	Rattus norvegicus	0-5
16001169-0	2006	Bcl-2-mediated potentiation of neocarzinostatin-induced apoptosis: requirement for caspase-3, sulfhydryl groups, and cleavable Bcl-2.	Zinostatin	31-47	BCL2, apoptosis regulator	Rattus norvegicus	127-132
16001169-2	2006	Paradoxical potentiation by Bcl-2 of apoptosis induced by the antineoplastic prodrug, neocarzinostatin (NCS), has been observed in PC12 pheochromocytoma cells.	Zinostatin	86-102	BCL2, apoptosis regulator	Rattus norvegicus	28-33
16001169-2	2006	Paradoxical potentiation by Bcl-2 of apoptosis induced by the antineoplastic prodrug, neocarzinostatin (NCS), has been observed in PC12 pheochromocytoma cells.	Zinostatin	104-107	BCL2, apoptosis regulator	Rattus norvegicus	28-33
16170329-7	2005	In contrast, neocarzinostatin and bleomycin induced death only in wt p53-expressing cells, in an apoptotic mode.	Zinostatin	13-29	tumor protein p53	Homo sapiens	69-72
16170329-5	2005	Neocarzinostatin and bleomycin induced an elevation in the p53 levels in wt p53-expressing cells, whereas methyl jasmonate did not.	Zinostatin	0-16	tumor protein p53	Homo sapiens	59-62
16170329-5	2005	Neocarzinostatin and bleomycin induced an elevation in the p53 levels in wt p53-expressing cells, whereas methyl jasmonate did not.	Zinostatin	0-16	tumor protein p53	Homo sapiens	76-79
15178448-3	2004	It was shown by biochemical fractionation procedure that PARP-1 as well as ATM increases at chromatin level after induction of DSB with neocarzinostatin (NCS).	Zinostatin	136-152	poly (ADP-ribose) polymerase family, member 1	Mus musculus	57-63
15967538-1	2005	Neocarzinostatin (NCS), an enediyne antimitotic agent, induces cell death in both p75NTR neurotrophin receptor (NTR)-positive and p75NTR-negative PC12 cells in a concentration-dependent fashion.	Zinostatin	0-16	nerve growth factor receptor	Rattus norvegicus	82-88
15967538-1	2005	Neocarzinostatin (NCS), an enediyne antimitotic agent, induces cell death in both p75NTR neurotrophin receptor (NTR)-positive and p75NTR-negative PC12 cells in a concentration-dependent fashion.	Zinostatin	0-16	nerve growth factor receptor	Rattus norvegicus	130-136
15967538-1	2005	Neocarzinostatin (NCS), an enediyne antimitotic agent, induces cell death in both p75NTR neurotrophin receptor (NTR)-positive and p75NTR-negative PC12 cells in a concentration-dependent fashion.	Zinostatin	18-21	nerve growth factor receptor	Rattus norvegicus	82-88
15967538-1	2005	Neocarzinostatin (NCS), an enediyne antimitotic agent, induces cell death in both p75NTR neurotrophin receptor (NTR)-positive and p75NTR-negative PC12 cells in a concentration-dependent fashion.	Zinostatin	18-21	nerve growth factor receptor	Rattus norvegicus	130-136
15967538-2	2005	However, p75NTR-positive cells demonstrate a higher susceptibility to NCS-induced cell damage.	Zinostatin	70-73	nerve growth factor receptor	Rattus norvegicus	9-15
15345673-8	2004	Addition of the radiomimetic agent neocarzinostatin for 4 h, however, induced a significant increase in IGF-IR levels in cells without ATM function.	Zinostatin	35-51	insulin like growth factor 1 receptor	Homo sapiens	104-110
15345673-8	2004	Addition of the radiomimetic agent neocarzinostatin for 4 h, however, induced a significant increase in IGF-IR levels in cells without ATM function.	Zinostatin	35-51	ATM serine/threonine kinase	Homo sapiens	135-138
15178448-3	2004	It was shown by biochemical fractionation procedure that PARP-1 as well as ATM increases at chromatin level after induction of DSB with neocarzinostatin (NCS).	Zinostatin	136-152	ataxia telangiectasia mutated	Mus musculus	75-78
15178448-3	2004	It was shown by biochemical fractionation procedure that PARP-1 as well as ATM increases at chromatin level after induction of DSB with neocarzinostatin (NCS).	Zinostatin	154-157	poly (ADP-ribose) polymerase family, member 1	Mus musculus	57-63
15178448-3	2004	It was shown by biochemical fractionation procedure that PARP-1 as well as ATM increases at chromatin level after induction of DSB with neocarzinostatin (NCS).	Zinostatin	154-157	ataxia telangiectasia mutated	Mus musculus	75-78
15178448-5	2004	NCS-induced phosphorylation of histone H2AX on serine 139 in Parp-1(-/-) embryonic stem cell (ES) clones was also higher than that in Parp-1(+/+) ES clone.	Zinostatin	0-3	poly (ADP-ribose) polymerase family, member 1	Mus musculus	61-67
15178448-5	2004	NCS-induced phosphorylation of histone H2AX on serine 139 in Parp-1(-/-) embryonic stem cell (ES) clones was also higher than that in Parp-1(+/+) ES clone.	Zinostatin	0-3	poly (ADP-ribose) polymerase family, member 1	Mus musculus	134-140
12135616-0	2002	Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism.	Zinostatin	0-16	MRE11 homolog, double strand break repair nuclease	Homo sapiens	25-30
14739606-1	2003	Transfection of PC12 pheochromocytoma cells with bcl-2 potentiates apoptosis induced by the antimitotic agent, neocarzinostatin (NCS).	Zinostatin	111-127	BCL2, apoptosis regulator	Rattus norvegicus	49-54
14739606-1	2003	Transfection of PC12 pheochromocytoma cells with bcl-2 potentiates apoptosis induced by the antimitotic agent, neocarzinostatin (NCS).	Zinostatin	129-132	BCL2, apoptosis regulator	Rattus norvegicus	49-54
14739606-11	2003	This makes it unlikely that cleavage of Bcl-2 is the only factor involved in potentiation of NCS-induced apoptosis by Bcl-2.	Zinostatin	93-96	BCL2, apoptosis regulator	Rattus norvegicus	118-123
14575640-0	2003	Neocarzinostatin-induced Rad51 nuclear focus formation is cell cycle regulated and aberrant in AT cells.	Zinostatin	0-16	RAD51 recombinase	Homo sapiens	25-30
14575640-3	2003	Herein, we demonstrate that the chemotherapeutic enediyne antibiotic neocarzinostatin induced Rad51, but not NBS1, nuclear focus formation in a cell- cycle-dependent manner.	Zinostatin	69-85	RAD51 recombinase	Homo sapiens	94-99
14575640-4	2003	Furthermore, neocarzinostatin-induced Rad51 foci formation revealed a slower kinetic change in AT cells, but not in wild-type or NBS cells.	Zinostatin	13-29	RAD51 recombinase	Homo sapiens	38-43
14575640-5	2003	In summary, our results suggest that neocarzinostatin induces Rad51 focus formation through an ATM- and cell-cycle-dependent, but NBS1-independent, pathway.	Zinostatin	37-53	RAD51 recombinase	Homo sapiens	62-67
14575640-5	2003	In summary, our results suggest that neocarzinostatin induces Rad51 focus formation through an ATM- and cell-cycle-dependent, but NBS1-independent, pathway.	Zinostatin	37-53	ATM serine/threonine kinase	Homo sapiens	95-98
14575640-5	2003	In summary, our results suggest that neocarzinostatin induces Rad51 focus formation through an ATM- and cell-cycle-dependent, but NBS1-independent, pathway.	Zinostatin	37-53	nibrin	Homo sapiens	130-134
12750435-0	2003	Neocarzinostatin induces an effective p53-dependent response in human papillomavirus-positive cervical cancer cells.	Zinostatin	0-16	tumor protein p53	Homo sapiens	38-41
12866953-5	2003	Moreover the incidence and the rejoining kinetics of neocarzinostatin-induced DNA double-strand breaks were identical in PARP-1+/+ and PARP-1-/- 3T3s.	Zinostatin	53-69	poly (ADP-ribose) polymerase family, member 1	Mus musculus	121-127
12866953-5	2003	Moreover the incidence and the rejoining kinetics of neocarzinostatin-induced DNA double-strand breaks were identical in PARP-1+/+ and PARP-1-/- 3T3s.	Zinostatin	53-69	poly (ADP-ribose) polymerase family, member 1	Mus musculus	135-141
12866953-7	2003	In contrast neocarzinostatin, even at supra-lethal concentration, was unable to initiate PARP-1 activation yet it induced H2AX histone phosphorylation in both PARP1+/+ and PARP-1-/- 3T3s as efficiently as gamma-rays and H2O2.	Zinostatin	12-28	poly (ADP-ribose) polymerase family, member 1	Mus musculus	172-178
12866953-9	2003	Even though both PARP-1 and ATM activation are major determinants of the cell response to gamma-rays and H2O2, data suggest that PARP-1-dependent poly(ADP-ribose) synthesis and ATM-dependent H2AX phosphorylation, are not inter-related in the repair pathway of neocarzinostatin-induced DNA double-strand breaks.	Zinostatin	260-276	poly (ADP-ribose) polymerase family, member 1	Mus musculus	129-135
12386164-4	2002	After treatment of HCT116 cells with a radiomimetic compound neocarzinostatin, active Chk2 exists as stable Thr-68-phosphorylated dimers as well as interconvertable Thr-68-unphosphorylated monomers and dimers.	Zinostatin	61-77	checkpoint kinase 2	Homo sapiens	86-90
12386164-5	2002	Interestingly, Chk2 from insect cells behaves by all criteria tested like active Chk2 from neocarzinostatin-treated HCT116 cells.	Zinostatin	91-107	checkpoint kinase 2	Homo sapiens	15-19
12386164-5	2002	Interestingly, Chk2 from insect cells behaves by all criteria tested like active Chk2 from neocarzinostatin-treated HCT116 cells.	Zinostatin	91-107	checkpoint kinase 2	Homo sapiens	81-85
12135616-0	2002	Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism.	Zinostatin	0-16	nibrin	Homo sapiens	87-91
12654916-2	2003	Surprisingly, although Chk2 purified from DNA damage sustaining cells has dramatically increased ability to phosphorylate Cdc25C when compared with untreated cells, its ability to phosphorylate p53 is weak before treatment, and there is no increase in its activity toward p53 after DNA damage by gamma irradiation or the radiomimetic agent neocarzinostatin.	Zinostatin	340-356	checkpoint kinase 2	Homo sapiens	23-27
12135616-3	2002	Here, we show that neocarzinostatin, a radiomimetic enediyne antibiotic, induces phosphorylation and nuclear focus formation of Mre11 and NBS1 through a cell cycle-independent mechanism.	Zinostatin	19-35	MRE11 homolog, double strand break repair nuclease	Homo sapiens	128-133
12135616-3	2002	Here, we show that neocarzinostatin, a radiomimetic enediyne antibiotic, induces phosphorylation and nuclear focus formation of Mre11 and NBS1 through a cell cycle-independent mechanism.	Zinostatin	19-35	nibrin	Homo sapiens	138-142
12135616-4	2002	Furthermore, neocarzinostatin-induced Mre11 phosphorylation and nuclear focus formation are defective in AT and NBS cells, but not wild type cells.	Zinostatin	13-29	MRE11 homolog, double strand break repair nuclease	Homo sapiens	38-43
12135616-4	2002	Furthermore, neocarzinostatin-induced Mre11 phosphorylation and nuclear focus formation are defective in AT and NBS cells, but not wild type cells.	Zinostatin	13-29	nibrin	Homo sapiens	112-115
12135616-5	2002	Our results suggest that ATM and NBS1 are required for the effective repair of neocarzinostatin-induced DNA double-strand breaks by both non-homologous end joining and homologous recombinational repair pathways.	Zinostatin	79-95	ATM serine/threonine kinase	Homo sapiens	25-28
12135616-5	2002	Our results suggest that ATM and NBS1 are required for the effective repair of neocarzinostatin-induced DNA double-strand breaks by both non-homologous end joining and homologous recombinational repair pathways.	Zinostatin	79-95	nibrin	Homo sapiens	33-37
12135616-0	2002	Neocarzinostatin induces Mre11 phosphorylation and focus formation through an ATM- and NBS1-dependent mechanism.	Zinostatin	0-16	ATM serine/threonine kinase	Homo sapiens	78-81
11872177-5	2002	When Molt-4 cells were induced to undergo apoptosis by neocarzinostatin (NCS) treatment, both caspase-3 activation and DFF-45 cleavage were observed.	Zinostatin	55-71	caspase 3	Homo sapiens	94-103
11872177-5	2002	When Molt-4 cells were induced to undergo apoptosis by neocarzinostatin (NCS) treatment, both caspase-3 activation and DFF-45 cleavage were observed.	Zinostatin	55-71	DNA fragmentation factor subunit alpha	Homo sapiens	119-125
11872177-5	2002	When Molt-4 cells were induced to undergo apoptosis by neocarzinostatin (NCS) treatment, both caspase-3 activation and DFF-45 cleavage were observed.	Zinostatin	73-76	caspase 3	Homo sapiens	94-103
11872177-5	2002	When Molt-4 cells were induced to undergo apoptosis by neocarzinostatin (NCS) treatment, both caspase-3 activation and DFF-45 cleavage were observed.	Zinostatin	73-76	DNA fragmentation factor subunit alpha	Homo sapiens	119-125
9635864-0	1998	Neocarzinostatin-induced mutations at the hprt locus in exponentially growing CHO cells, compared with spontaneous mutations.	Zinostatin	0-16	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	42-46
11752215-1	2002	Previous studies from our laboratory have demonstrated that Bcl-2 has a proapoptotic effect on neocarzinostatin (NCS)-treated PC12 pheochromocytoma cells.	Zinostatin	95-111	BCL2, apoptosis regulator	Rattus norvegicus	60-65
11752215-1	2002	Previous studies from our laboratory have demonstrated that Bcl-2 has a proapoptotic effect on neocarzinostatin (NCS)-treated PC12 pheochromocytoma cells.	Zinostatin	113-116	BCL2, apoptosis regulator	Rattus norvegicus	60-65
11752215-8	2002	In in vivo experiments, xenografts of bcl-2-transfected PC12 cells were more susceptible to NCS toxicity than were xenografts of mock-transfected PC12 cells.	Zinostatin	92-95	BCL2, apoptosis regulator	Rattus norvegicus	38-43
11641782-2	2001	Nonetheless, both mock- and bcl-2-transfected MCF-7 cells undergo apoptosis after treatment with a variety of stimuli, including the DNA-cleaving antimitotic agent, neocarzinostatin (NCS).	Zinostatin	165-181	BCL2 apoptosis regulator	Homo sapiens	28-33
11641782-2	2001	Nonetheless, both mock- and bcl-2-transfected MCF-7 cells undergo apoptosis after treatment with a variety of stimuli, including the DNA-cleaving antimitotic agent, neocarzinostatin (NCS).	Zinostatin	183-186	BCL2 apoptosis regulator	Homo sapiens	28-33
11481424-4	2001	Unlike p33ING1b, p33ING2 is induced by the DNA-damaging agents etoposide and neocarzinostatin.	Zinostatin	77-93	inhibitor of growth family member 2	Homo sapiens	17-24
11402319-5	2001	An over twofold increase in degree of apoptosis was observed in TRAF2DeltaN expressing cells that were treated with actinomycin D, anisomycin or with the radiomimetic drug neocarzinostatin.	Zinostatin	172-188	TNF receptor associated factor 2	Homo sapiens	64-69
11294647-0	2001	The cellular response to DNA damage induced by the enediynes C-1027 and neocarzinostatin includes hyperphosphorylation and increased nuclear retention of replication protein a (RPA) and trans inhibition of DNA replication.	Zinostatin	72-88	replication protein A1	Homo sapiens	154-175
11294647-0	2001	The cellular response to DNA damage induced by the enediynes C-1027 and neocarzinostatin includes hyperphosphorylation and increased nuclear retention of replication protein a (RPA) and trans inhibition of DNA replication.	Zinostatin	72-88	replication protein A1	Homo sapiens	177-180
11294647-8	2001	C-1027 and neocarzinostatin doses that caused similar levels of DNA damage resulted in equivalent increases in RPA32 hyperphosphorylation and RPA nuclear retention and decreases in replication activity, suggesting a common response to enediyne-induced DNA damage.	Zinostatin	11-27	replication protein A2	Homo sapiens	111-116
11294647-8	2001	C-1027 and neocarzinostatin doses that caused similar levels of DNA damage resulted in equivalent increases in RPA32 hyperphosphorylation and RPA nuclear retention and decreases in replication activity, suggesting a common response to enediyne-induced DNA damage.	Zinostatin	11-27	replication protein A1	Homo sapiens	111-114
11091429-0	2000	Chemical Synthesis and DNA Photocleavage of the Intercalator-Carbohydrate Hybrid Moiety of the Neocarzinostatin Chromophore This research was partially supported by a Grant-in-Aid for Encouragement of Young Scientists from the Ministry of Education, Science, Sports, and Culture, Japan, and a research grant of Keio University Special Grant-in-Aid for Innovative Collaborative Research Projects.	Zinostatin	95-111	activation induced cytidine deaminase	Homo sapiens	176-179
11091429-0	2000	Chemical Synthesis and DNA Photocleavage of the Intercalator-Carbohydrate Hybrid Moiety of the Neocarzinostatin Chromophore This research was partially supported by a Grant-in-Aid for Encouragement of Young Scientists from the Ministry of Education, Science, Sports, and Culture, Japan, and a research grant of Keio University Special Grant-in-Aid for Innovative Collaborative Research Projects.	Zinostatin	95-111	activation induced cytidine deaminase	Homo sapiens	344-347
10411991-1	1999	The induction of apoptosis in PC12 cells by the enediyne neocarzinostatin (NCS) is paradoxically potentiated by overexpression of bcl-2.	Zinostatin	75-78	BCL2, apoptosis regulator	Rattus norvegicus	130-135
10411991-3	1999	We now report that overexpression of bcl-2 in PC12 cells does not protect the cells from NCS-induced oxidation of membrane phosphatidylserine (PS), and results in potentiation of NCS-induced externalization of membrane PS, two events associated with the apoptosis final common pathway.	Zinostatin	179-182	BCL2, apoptosis regulator	Rattus norvegicus	37-42
9952316-0	1999	Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3"-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation.	Zinostatin	145-161	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	17-53
9952316-0	1999	Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3"-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation.	Zinostatin	145-161	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	55-60
11850813-5	2002	While studying gene expression in control and A-T cells following treatment with the radiomimetic chemical neocarzinostatin (NCS), we identified an expressed sequence tag that represented a gene that was induced by DSBs in an ATM-dependent manner.	Zinostatin	107-123	ATM serine/threonine kinase	Homo sapiens	226-229
9757206-0	1998	[Increased effect of neocarzinostatin bound to chimeric Fab fragments of monoclonal antibody A7 on the proliferation of human pancreatic carcinoma].	Zinostatin	21-37	FA complementation group B	Homo sapiens	56-59
9635864-1	1998	Spontaneous mutations and neocarzinostatin-induced mutations were investigated in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in exponentially growing Chinese hamster ovary cells.	Zinostatin	26-42	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	86-132
9635864-1	1998	Spontaneous mutations and neocarzinostatin-induced mutations were investigated in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene in exponentially growing Chinese hamster ovary cells.	Zinostatin	26-42	hypoxanthine-guanine phosphoribosyltransferase	Cricetulus griseus	134-138
8761376-0	1996	Distribution of neocarzinostatin conjugated to biotinylated chimeric monoclonal antibody Fab fragments after administration of avidin.	Zinostatin	16-32	FA complementation group B	Homo sapiens	89-92
9244351-9	1997	Ectopic expression of ATM in A-T cells restored normal sensitivity to ionizing radiation and the radiomimetic drug neocarzinostatin, and a normal pattern of post-irradiation DNA synthesis, which represents an S-phase checkpoint.	Zinostatin	115-131	ATM serine/threonine kinase	Homo sapiens	22-25
9167276-0	1997	Mechanism of free and conjugated neocarzinostatin activity: studies on chromophore and protein uptake using a transferrin-neocarzinostatin conjugate.	Zinostatin	33-49	transferrin	Homo sapiens	110-121
9167276-0	1997	Mechanism of free and conjugated neocarzinostatin activity: studies on chromophore and protein uptake using a transferrin-neocarzinostatin conjugate.	Zinostatin	122-138	transferrin	Homo sapiens	110-121
9119750-2	1997	Moreover, because Fab fragments of mAbs are able to penetrate target tumors easily, they may be more suitable than intact mAb to be carriers of anticancer agents such as neocarzinostatin (NCS), which are rapidly inactivated in the blood.	Zinostatin	170-186	FA complementation group B	Homo sapiens	18-21
9119750-2	1997	Moreover, because Fab fragments of mAbs are able to penetrate target tumors easily, they may be more suitable than intact mAb to be carriers of anticancer agents such as neocarzinostatin (NCS), which are rapidly inactivated in the blood.	Zinostatin	188-191	FA complementation group B	Homo sapiens	18-21
9015149-0	1997	Targeted base substitutions and small deletions induced by neocarzinostatin at the APRT locus in plateau-phase CHO cells.	Zinostatin	59-75	adenine phosphoribosyltransferase	Cricetulus griseus	83-87
9015149-1	1997	Treatment of confluence-arrested CHO-D422 cells for 48 h with low concentrations (0.5-3 nM) of the radiomimetic antibiotic neocarzinostatin resulted in an increase in up to 11-fold in the frequency of mutations at the hemizygous APRT locus.	Zinostatin	123-139	adenine phosphoribosyltransferase	Cricetulus griseus	229-233
9015149-6	1997	Quantitative analysis of neocarzinostatin-induced damage to APRT DNA in vitro confirmed the association between lesions involving concommitant damage to both DNA strands, and mutations.	Zinostatin	25-41	adenine phosphoribosyltransferase	Cricetulus griseus	60-64
8761376-1	1996	We have developed chimeric Fab fragments of MAb A7 (chA7Fab) and have reported on their potential usefulness as a carrier of neocarzinostatin (NCS).	Zinostatin	125-141	FA complementation group B	Homo sapiens	27-30
8761376-1	1996	We have developed chimeric Fab fragments of MAb A7 (chA7Fab) and have reported on their potential usefulness as a carrier of neocarzinostatin (NCS).	Zinostatin	125-141	FA complementation group B	Homo sapiens	56-59
8761376-1	1996	We have developed chimeric Fab fragments of MAb A7 (chA7Fab) and have reported on their potential usefulness as a carrier of neocarzinostatin (NCS).	Zinostatin	143-146	FA complementation group B	Homo sapiens	27-30
8630275-1	1996	Neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of MAb A7 (chA7Fab) directed against human pancreatic carcinoma.	Zinostatin	18-21	FA complementation group B	Homo sapiens	68-71
8144398-1	1994	The anticancer polypeptide neocarzinostatin (NCS) was covalently coupled to a human/mouse chimeric Fab A7 monoclonal antibody (chFabA7) and the in vivo efficacy of this conjugate was examined.	Zinostatin	27-43	FA complementation group B	Homo sapiens	99-102
8630275-1	1996	Neocarzinostatin (NCS) was bound covalently to human/mouse chimeric Fab fragments of MAb A7 (chA7Fab) directed against human pancreatic carcinoma.	Zinostatin	0-16	FA complementation group B	Homo sapiens	68-71
7582949-1	1995	It is shown by fluorescence spectroscopy that the post-activated form of neocarzinostatin chromophore (NCSi-glu) can form stable complexes with single-site oligonucleotides (SSOs) featuring sequences known to be involved in double stranded (AGC.GCT, AGT.ACT, AGA.TCT, ACA.TGT) or single stranded (AGG.CCT) cleavage (attacked residues in bold).	Zinostatin	73-89	angiotensinogen	Homo sapiens	250-253
7811256-0	1994	Generation of free radicals from neocarzinostatin mediated by NADPH/cytochrome P-450 reductase via activation of enediyne chromophore.	Zinostatin	33-49	cytochrome p450 oxidoreductase	Homo sapiens	62-94
8144398-1	1994	The anticancer polypeptide neocarzinostatin (NCS) was covalently coupled to a human/mouse chimeric Fab A7 monoclonal antibody (chFabA7) and the in vivo efficacy of this conjugate was examined.	Zinostatin	45-48	FA complementation group B	Homo sapiens	99-102
1531616-0	1992	Neocarzinostatin-mediated DNA damage in a model AGT.ACT site: mechanistic studies of thiol-sensitive partitioning of C4" DNA damage products.	Zinostatin	0-16	angiotensinogen	Homo sapiens	48-51
8466903-1	1993	Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA.	Zinostatin	27-43	complement C2	Homo sapiens	148-151
8466903-1	1993	Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA.	Zinostatin	27-43	complement C6	Homo sapiens	156-159
8463135-0	1993	Intracellular metabolism and cytotoxicity of transferrin-neocarzinostatin conjugates of differing molar ratios.	Zinostatin	57-73	transferrin	Homo sapiens	45-56
8463135-1	1993	Transferrin-neocarzinostatin (NCS) conjugates with differing molar ratios of drug to protein were synthesized and their intracellular metabolism was investigated.	Zinostatin	12-28	transferrin	Homo sapiens	0-11
8398344-1	1993	Neocarzinostatin (NCS) linked to the thiol group on the hinge region of the Fab" fragment of GA-17, a murine monoclonal antibody reacting with tyrosine-specific phosphorylated antigens, which are exclusively expressed on the cell surface of human astrocytomas, was evaluated for in vivo activity.	Zinostatin	0-16	FA complementation group B	Homo sapiens	76-79
8398344-1	1993	Neocarzinostatin (NCS) linked to the thiol group on the hinge region of the Fab" fragment of GA-17, a murine monoclonal antibody reacting with tyrosine-specific phosphorylated antigens, which are exclusively expressed on the cell surface of human astrocytomas, was evaluated for in vivo activity.	Zinostatin	0-16	eukaryotic translation initiation factor 3 subunit M	Homo sapiens	93-98
8398344-1	1993	Neocarzinostatin (NCS) linked to the thiol group on the hinge region of the Fab" fragment of GA-17, a murine monoclonal antibody reacting with tyrosine-specific phosphorylated antigens, which are exclusively expressed on the cell surface of human astrocytomas, was evaluated for in vivo activity.	Zinostatin	18-21	FA complementation group B	Homo sapiens	76-79
8398344-1	1993	Neocarzinostatin (NCS) linked to the thiol group on the hinge region of the Fab" fragment of GA-17, a murine monoclonal antibody reacting with tyrosine-specific phosphorylated antigens, which are exclusively expressed on the cell surface of human astrocytomas, was evaluated for in vivo activity.	Zinostatin	18-21	eukaryotic translation initiation factor 3 subunit M	Homo sapiens	93-98
1390698-0	1992	Selective abstraction of 2H from C-1" of the C residue in AGC.ICT by the radical center at C-2 of activated neocarzinostatin chromophore: structure of the drug/DNA complex responsible for bistranded lesion formation.	Zinostatin	108-124	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	33-36
1390698-0	1992	Selective abstraction of 2H from C-1" of the C residue in AGC.ICT by the radical center at C-2 of activated neocarzinostatin chromophore: structure of the drug/DNA complex responsible for bistranded lesion formation.	Zinostatin	108-124	complement C2	Homo sapiens	91-94
1390698-1	1992	Glutathione-activated neocarzinostatin chromophore (NCS-Chrom) generates bistranded lesions at AGC.GCT sequences in DNA, consisting of an abasic site at the C residue and a strand break at the T residue on the complementary strand, due to hydrogen atom abstraction from C-1" and C-5", respectively.	Zinostatin	22-38	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	270-273
1390698-1	1992	Glutathione-activated neocarzinostatin chromophore (NCS-Chrom) generates bistranded lesions at AGC.GCT sequences in DNA, consisting of an abasic site at the C residue and a strand break at the T residue on the complementary strand, due to hydrogen atom abstraction from C-1" and C-5", respectively.	Zinostatin	22-38	complement C5	Homo sapiens	279-282
1386670-0	1992	Neocarzinostatin acts as a sensitive probe of DNA microheterogeneity: switching of chemistry from C-1" to C-4" by a G.T mismatch 5" to the site of DNA damage.	Zinostatin	0-16	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	98-101
1386670-0	1992	Neocarzinostatin acts as a sensitive probe of DNA microheterogeneity: switching of chemistry from C-1" to C-4" by a G.T mismatch 5" to the site of DNA damage.	Zinostatin	0-16	complement C4A (Rodgers blood group)	Homo sapiens	106-109
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Zinostatin	38-54	complement C5	Homo sapiens	148-151
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Zinostatin	38-54	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	154-157
1386670-1	1992	The diradical form of thiol-activated neocarzinostatin chromophore resides in the minor groove of DNA, where it has access to hydrogen atoms at the C-5", C-1", and C-4" positions of deoxyribose on each strand.	Zinostatin	38-54	complement C4A (Rodgers blood group)	Homo sapiens	164-167
8363646-0	1993	Prevention of neocarzinostatin-induced cell death and morphologic change in SK-N-SH human neuroblastoma cells by continuous exposure to nerve growth factor.	Zinostatin	14-30	nerve growth factor	Homo sapiens	136-155
8363646-7	1993	NGF (100-1000 ng/mL) protected SK-N-SH cells from the morphological and cytocidal effects of neocarzinostatin (1-hr exposure, 0.017 to 0.033 micrograms/mL).	Zinostatin	93-109	nerve growth factor	Homo sapiens	0-3
8363646-8	1993	Protection from neocarzinostatin required that NGF be continuously present for a period beginning 24 hr prior to neocarzinostatin exposure and continuing for the duration of the experiment, implying that the protection afforded by NGF has a latency necessitating pretreatment, and is reversible.	Zinostatin	16-32	nerve growth factor	Homo sapiens	47-50
8363646-9	1993	These results suggest that neocarzinostatin is taken up by the cells and can exert its effects once NGF is removed, even after neocarzinostatin is washed out of the medium.	Zinostatin	27-43	nerve growth factor	Homo sapiens	100-103
8363646-10	1993	The signal transduction cascade triggered by NGF receptor binding may prevent the action of neocarzinostatin or the expression of the cellular changes induced in SK-N-SH cells by neocarzinostatin.	Zinostatin	92-108	nerve growth factor	Homo sapiens	45-48
8363646-10	1993	The signal transduction cascade triggered by NGF receptor binding may prevent the action of neocarzinostatin or the expression of the cellular changes induced in SK-N-SH cells by neocarzinostatin.	Zinostatin	179-195	nerve growth factor	Homo sapiens	45-48
8393501-0	1993	Intratumoral administration of neocarzinostatin conjugated to monoclonal antibody A7 in a model of pancreatic cancer.	Zinostatin	31-47	immunoglobulin kappa variable 2D-24 (non-functional)	Homo sapiens	82-84
1531616-1	1992	Double-strand (DS) DNA damage caused by neocarzinostatin (NCS) has been studied in the trinucleotide AGT-ACT sequence in an AP-1 transcription factor binding site.	Zinostatin	40-56	angiotensinogen	Homo sapiens	101-104
1531616-1	1992	Double-strand (DS) DNA damage caused by neocarzinostatin (NCS) has been studied in the trinucleotide AGT-ACT sequence in an AP-1 transcription factor binding site.	Zinostatin	58-61	angiotensinogen	Homo sapiens	101-104
1826561-0	1991	Selective abstraction of 2H from C-5" of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the activated drug-DNA complex.	Zinostatin	137-153	complement C5	Homo sapiens	33-36
1826561-0	1991	Selective abstraction of 2H from C-5" of thymidylate in an oligodeoxynucleotide by the radical center at C-6 of the diradical species of neocarzinostatin: chemical evidence for the structure of the activated drug-DNA complex.	Zinostatin	137-153	complement C6	Homo sapiens	105-108
1825606-0	1991	Neocarzinostatin-induced hydrogen atom abstraction from C-4" and C-5" of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects.	Zinostatin	0-16	complement C4A (Rodgers blood group)	Homo sapiens	56-59
1825606-0	1991	Neocarzinostatin-induced hydrogen atom abstraction from C-4" and C-5" of the T residue at a d(GT) step in oligonucleotides: shuttling between deoxyribose attack sites based on isotope selection effects.	Zinostatin	0-16	complement C5	Homo sapiens	65-68
1693487-5	1990	In this context, transferrin-neocarzinostatin was examined in our laboratory both in vitro and in vivo for its anticancer activity and was found to suppress tumor growth more significantly than neocarzinostatin alone on the basis of molar ratio.	Zinostatin	29-45	transferrin	Homo sapiens	17-28
1693487-5	1990	In this context, transferrin-neocarzinostatin was examined in our laboratory both in vitro and in vivo for its anticancer activity and was found to suppress tumor growth more significantly than neocarzinostatin alone on the basis of molar ratio.	Zinostatin	194-210	transferrin	Homo sapiens	17-28
2360469-7	1990	This correlation between the O6-MT activity and the cellular resistance to nitrosoureas as ACNU and MCNU was not observed among other antitumour drugs, which included bleomycin (BLM), neocarzinostatin (NCS), cis-diamminedichloroplatinum (II) (CDDP), and etoposide (VP-16) in clinical use for brain tumour chemotherapy.	Zinostatin	184-200	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	29-34
2360469-7	1990	This correlation between the O6-MT activity and the cellular resistance to nitrosoureas as ACNU and MCNU was not observed among other antitumour drugs, which included bleomycin (BLM), neocarzinostatin (NCS), cis-diamminedichloroplatinum (II) (CDDP), and etoposide (VP-16) in clinical use for brain tumour chemotherapy.	Zinostatin	202-205	O-6-methylguanine-DNA methyltransferase	Rattus norvegicus	29-34
2144279-6	1990	The chemical structures of the cleavage sites suggest a model in which a neocarzinostatin-induced double-strand break results from abstraction of a C5" hydrogen atom from the T of ACT and the C4" hydrogen atom of the T of AGT by a single molecule of the diradical form of the drug.	Zinostatin	73-89	angiotensinogen	Homo sapiens	222-225
2139019-0	1990	Kinetics of internalization and cytotoxicity of transferrin-neocarzinostatin conjugate in human leukemia cell line, K562.	Zinostatin	60-76	serotransferrin	Bos taurus	48-59
2139019-1	1990	Human serum transferrin was conjugated with an anticancer-active polypeptide, neocarzinostatin, by using N-succinimidyl 1-3-(2-pyridyldithio)propionate.	Zinostatin	78-94	transferrin	Homo sapiens	12-23
2139019-2	1990	The conjugate consisted of 1.8 mol of neocarzinostatin per 1 mol of transferrin on average and retained cytotoxic activity against human tumor cells.	Zinostatin	38-54	transferrin	Homo sapiens	68-79
2139019-4	1990	The LD50 values of the conjugate and neocarzinostatin alone in the presence of excess native bovine transferrin were 0.20 microgram/ml and 1.80 micrograms/ml, respectively, suggesting that the effect of the conjugate was greater than that of neocarzinostatin alone.	Zinostatin	37-53	serotransferrin	Bos taurus	100-111