PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35056748-11	2022	For the first time, the unique syn-form was found in the crystal of an acyclic bispidine-based bis-amide.	bis-amide	95-104	synemin	Homo sapiens	31-34
28377059-0	2017	Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors.	bis-amide	38-47	colony stimulating factor 1 receptor	Mus musculus	63-68
28377059-4	2017	Herein we describe our lead optimization effort that resulted in the identification of a potent, cellular active and orally bioavailable bis-amide CSF1R inhibitor.	bis-amide	137-146	colony stimulating factor 1 receptor	Mus musculus	147-152
21123452-7	2011	The bis-amide compound 5 was of particular interest, as it was able to inhibit tumor growth mediated by drug resistant SMO in a murine allograft model of MB.	bis-amide	4-13	smoothened, frizzled class receptor	Mus musculus	119-122
16823784-6	2006	The results show that the unexpectedly low anion binding ability of the isophthalic acid-based receptors is due to the self-complementary nature of the isophthalic bis-amide fragments: when two such moieties are present within a sufficiently flexible macrocycle, they adopt syn-anti conformations and bind each other by two strong intramolecular hydrogen bonds that close the macrocyclic cavity.	bis-amide	164-173	synemin	Homo sapiens	274-277
31740054-0	2020	Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis.	bis-amide	161-170	matrix metallopeptidase 9	Homo sapiens	65-70
31740054-8	2020	Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential.	bis-amide	93-102	matrix metallopeptidase 9	Homo sapiens	121-126
31740054-8	2020	Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential.	bis-amide	93-102	AKT serine/threonine kinase 1	Homo sapiens	127-130
31740054-8	2020	Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential.	bis-amide	93-102	caspase 3	Homo sapiens	155-164