PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31960173-1 2020 BACKGROUND: 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid (GSAO) when conjugated at the gamma-glutamyl residue with fluorophores and radio-isotopes is able to image dead and dying cells in vitro and in vivo by binding to intracellular 90-kDa heat shock proteins (hsp90) when cell membrane integrity is compromised. phenylarsonous acid 46-65 heat shock protein 90 alpha family class A member 1 Homo sapiens 271-276 25482950-7 2014 The cytotoxicity of PENAO was enhanced by DCA by a mechanism involving increased reactive oxygen species in both T-47D and MDA-MB-231 cells, however further investigations found it did not always involve PDK2 inhibition or reduction of the mitochondrial membrane potential, which are the accepted mechanisms for DCA induction of apoptosis. phenylarsonous acid 20-25 pyruvate dehydrogenase kinase 2 Homo sapiens 204-208 28470989-3 2017 The formation of these newly discovered methylated metabolites from reactions involving trivalent phenylarsonous acid substrates, S-adenosylmethionine, and the arsenic (+3 oxidation state) methyltransferase enzyme As3MT suggests that these compounds are formed by addition of a methyl group to a trivalent phenylarsenical substrate in an enzymatic process. phenylarsonous acid 98-117 arsenite methyltransferase Gallus gallus 160-206 28470989-3 2017 The formation of these newly discovered methylated metabolites from reactions involving trivalent phenylarsonous acid substrates, S-adenosylmethionine, and the arsenic (+3 oxidation state) methyltransferase enzyme As3MT suggests that these compounds are formed by addition of a methyl group to a trivalent phenylarsenical substrate in an enzymatic process. phenylarsonous acid 98-117 arsenite methyltransferase Gallus gallus 214-219 21595632-8 2011 Moreover, PAO (phenylarsonous acid), which cross-links two cysteine thiols that are in close proximity, and MMTS (methyl methanethiolsulfonate), at concentrations where it oxidizes closely spaced cysteine residues to a cystine residue, were efficient activators of cellular TF. phenylarsonous acid 10-13 coagulation factor III, tissue factor Homo sapiens 274-276 22448968-3 2012 The trivalent arsenical moiety of GSAO and PENAO reacts with two matrix facing cysteine residues of ANT, inactivating the transporter. phenylarsonous acid 43-48 solute carrier family 25 member 6 Homo sapiens 100-103 21595632-8 2011 Moreover, PAO (phenylarsonous acid), which cross-links two cysteine thiols that are in close proximity, and MMTS (methyl methanethiolsulfonate), at concentrations where it oxidizes closely spaced cysteine residues to a cystine residue, were efficient activators of cellular TF. phenylarsonous acid 15-34 coagulation factor III, tissue factor Homo sapiens 274-276