PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
19007202-4	2008	(E)-Alkene- and hydroxyethylene-type isostere-containing analogues maintained the original activity with higher stability in murine serum and resistance to MMP-9-mediated cleavage.	isostere	37-45	matrix metallopeptidase 9	Homo sapiens	156-161
21803585-1	2011	Previously, we reported potent pentapeptidic BACE1 inhibitors with the hydroxymethylcarbonyl isostere as a substrate transition-state mimic.	isostere	93-101	beta-secretase 1	Homo sapiens	45-50