PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
16005460-3	2006	The -75G/A single nucleotide polymorphism (SNP) in the apolipoprotein A1 gene (APOA1) promoter has been reported to be associated with HDL-C concentrations as well as HDL-C response to dietary changes in polyunsaturated fat intake.	polyunsaturated fat	204-223	apolipoprotein A1	Homo sapiens	55-72
16005460-3	2006	The -75G/A single nucleotide polymorphism (SNP) in the apolipoprotein A1 gene (APOA1) promoter has been reported to be associated with HDL-C concentrations as well as HDL-C response to dietary changes in polyunsaturated fat intake.	polyunsaturated fat	204-223	apolipoprotein A1	Homo sapiens	79-84
11914742-0	2002	Substituting dietary saturated fat with polyunsaturated fat changes abdominal fat distribution and improves insulin sensitivity.	polyunsaturated fat	40-59	insulin	Homo sapiens	108-115
16317133-8	2005	Serum DHEAS was positively associated with the percentage of energy from total fat (P = 0.007), saturated fat (P = 0.009), monounsaturated fat (P = 0.006), and polyunsaturated fat (P = 0.04).	polyunsaturated fat	160-179	sulfotransferase family 2A member 1	Homo sapiens	6-11
15333739-6	2004	G6PD activity is enhanced by the consumption of diets high in carbohydrate and is inhibited by the consumption of polyunsaturated fat.	polyunsaturated fat	114-133	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
15181189-0	2004	Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats.	polyunsaturated fat	69-88	pancreatic lipase	Rattus norvegicus	0-17
15181189-10	2004	In conclusion, PL and PLRP2 gene expression is regulated anticoordinately by the amount of dietary polyunsaturated fat starting as early as the preweanling phase of development.	polyunsaturated fat	99-118	pancreatic lipase	Rattus norvegicus	15-17
15181189-10	2004	In conclusion, PL and PLRP2 gene expression is regulated anticoordinately by the amount of dietary polyunsaturated fat starting as early as the preweanling phase of development.	polyunsaturated fat	99-118	pancreatic lipase related protein 2	Rattus norvegicus	22-27
12072438-2	2002	We have compared the nuclear accumulation of partially and fully spliced mRNA for G6PD in the livers of mice fed diets high versus low in polyunsaturated fat.	polyunsaturated fat	138-157	glucose-6-phosphate dehydrogenase 2	Mus musculus	82-86
12072438-3	2002	Consumption of a diet high in polyunsaturated fat decreased the accumulation of partially spliced forms of the G6PD pre-mRNA.	polyunsaturated fat	30-49	glucose-6-phosphate dehydrogenase 2	Mus musculus	111-115
11971939-1	2002	Dietary polyunsaturated fat is known to suppress expression of fatty acid synthase (FAS), a central enzyme in de novo lipogenesis.	polyunsaturated fat	8-27	fatty acid synthase	Homo sapiens	63-82
11971939-1	2002	Dietary polyunsaturated fat is known to suppress expression of fatty acid synthase (FAS), a central enzyme in de novo lipogenesis.	polyunsaturated fat	8-27	fatty acid synthase	Homo sapiens	84-87
11971939-3	2002	We previously reported that the first 2.1 kb of the FAS promoter are sufficient for transcriptional induction by a high carbohydrate diet as well as suppression by polyunsaturated fat in transgenic mice.	polyunsaturated fat	164-183	fatty acid synthase	Homo sapiens	52-55
11971939-5	2002	Feeding polyunsaturated fat prevented both the low-level activation of the -278 FAS promoter which contains the -150 sterol response element (SRE), as well as the maximal activation of the longer -444 FAS promoter.	polyunsaturated fat	8-27	fatty acid synthase	Homo sapiens	80-83
11971939-5	2002	Feeding polyunsaturated fat prevented both the low-level activation of the -278 FAS promoter which contains the -150 sterol response element (SRE), as well as the maximal activation of the longer -444 FAS promoter.	polyunsaturated fat	8-27	fatty acid synthase	Homo sapiens	201-204
11864853-7	2002	Concentrations of lipoproteins containing both apo A-I and apo A-II (Lp A-I:A-II) were lower with both polyunsaturated fat diets in the women but significantly higher in the men.	polyunsaturated fat	103-122	apolipoprotein A1	Homo sapiens	47-54
11864853-7	2002	Concentrations of lipoproteins containing both apo A-I and apo A-II (Lp A-I:A-II) were lower with both polyunsaturated fat diets in the women but significantly higher in the men.	polyunsaturated fat	103-122	apolipoprotein A2	Homo sapiens	59-67
9303470-8	1997	Polyunsaturated fat stimulated a marked increase (P < .001) in serum insulin relative to controls within 3 wk, whereas SAT and HPU increased (P < .05) serum insulin only after 6 to 7 wk.	polyunsaturated fat	0-19	insulin	Bos taurus	72-79
11812004-0	2002	NF-Y involvement in the polyunsaturated fat inhibition of fatty acid synthase gene transcription.	polyunsaturated fat	24-43	fatty acid synthase	Homo sapiens	58-77
9434742-1	1997	Expression of the glucose-6-phosphate dehydrogenase (G6PD) gene is inhibited by addition of polyunsaturated fat to a high-carbohydrate diet and stimulated by feeding a high-carbohydrate diet to starved mice.	polyunsaturated fat	92-111	glucose-6-phosphate dehydrogenase 2	Mus musculus	18-51
9434742-1	1997	Expression of the glucose-6-phosphate dehydrogenase (G6PD) gene is inhibited by addition of polyunsaturated fat to a high-carbohydrate diet and stimulated by feeding a high-carbohydrate diet to starved mice.	polyunsaturated fat	92-111	glucose-6-phosphate dehydrogenase 2	Mus musculus	53-57
8806735-1	1996	The activity of glucose-6-phosphate dehydrogenase (G6PD) is inhibited by the addition of polyunsaturated fat (PUFA) to a high carbohydrate diet.	polyunsaturated fat	89-108	glucose-6-phosphate dehydrogenase 2	Mus musculus	16-49
8806735-1	1996	The activity of glucose-6-phosphate dehydrogenase (G6PD) is inhibited by the addition of polyunsaturated fat (PUFA) to a high carbohydrate diet.	polyunsaturated fat	89-108	glucose-6-phosphate dehydrogenase 2	Mus musculus	51-55
7749056-7	1995	Specifically, obesity--particularly central obesity, physical inactivity, and possibly a low dietary polyunsaturated fat to saturated fat ratio--are major determinants of insulin resistance and hyperinsulinemia, and appear related to colon cancer risk.	polyunsaturated fat	101-120	insulin	Homo sapiens	171-178
2175783-0	1990	Suppression of rat hepatic fatty acid synthase and S14 gene transcription by dietary polyunsaturated fat.	polyunsaturated fat	85-104	fatty acid synthase	Rattus norvegicus	27-46
8190122-0	1994	Regulation of polyunsaturated fat induced postprandial hypercholesterolemia by a novel gene Phc-2.	polyunsaturated fat	14-33	polyhomeotic 2	Mus musculus	92-97
8190122-7	1994	From this result, we found that the postprandial hypercholesterolemic response to an acute polyunsaturated fat-cholesterol feed, cosegregated with the a allele at the Gpd-1 and Ahd-1 loci, on mouse chromosome 4.	polyunsaturated fat	91-110	glycerol-3-phosphate dehydrogenase 1 (soluble)	Mus musculus	167-172
8190122-7	1994	From this result, we found that the postprandial hypercholesterolemic response to an acute polyunsaturated fat-cholesterol feed, cosegregated with the a allele at the Gpd-1 and Ahd-1 loci, on mouse chromosome 4.	polyunsaturated fat	91-110	aldehyde dehydrogenase 4 family, member A1	Mus musculus	177-182
8190122-9	1994	Thus polyunsaturated fat-cholesterol induced postprandial hypercholesterolemia appeared to be genetically determined by a gene located between the Gpd-1 and Ahd-1 loci, in mice.	polyunsaturated fat	5-24	glycerol-3-phosphate dehydrogenase 1 (soluble)	Mus musculus	147-152
8190122-9	1994	Thus polyunsaturated fat-cholesterol induced postprandial hypercholesterolemia appeared to be genetically determined by a gene located between the Gpd-1 and Ahd-1 loci, in mice.	polyunsaturated fat	5-24	aldehyde dehydrogenase 4 family, member A1	Mus musculus	157-162
8190122-10	1994	The putative gene regulating polyunsaturated fat-cholesterol induced post-absorptive hypercholesterolemia was designated Phc-2.	polyunsaturated fat	29-48	polyhomeotic 2	Mus musculus	121-126
7877894-7	1994	This effect of amount of dietary fat on prolactin in proestrus-estrus animals anesthetized with ether was predominantly present in animals fed polyunsaturated fat (p < 0.05, 1-way ANOVA and Tukey"s test) and was statistically not significant in rats fed saturated fat diets.	polyunsaturated fat	143-162	prolactin	Rattus norvegicus	40-49
7877894-12	1994	Because stress is a frequent and normal phenomenon, this observation implies that the mammary glands of animals with a high dietary intake of polyunsaturated fat are frequently exposed to higher circulating prolactin concentrations than rats fed a low-fat diet, which may be a major mechanism by which dietary fat enhances rat mammary carcinogenesis.	polyunsaturated fat	142-161	prolactin	Rattus norvegicus	207-216
2175783-0	1990	Suppression of rat hepatic fatty acid synthase and S14 gene transcription by dietary polyunsaturated fat.	polyunsaturated fat	85-104	thyroid hormone responsive	Rattus norvegicus	51-54
2174847-9	1990	Dietary polyunsaturated fat increased the number of GH receptors in liver and PRL receptors in mammary parenchyma.	polyunsaturated fat	8-27	somatotropin	Ovis aries	52-54
6804585-9	1982	Chylomicron apoA-I/triglyceride and apoA-II/triglyceride mass ratios were lower in polyunsaturated fat-fed animals (A-I/TG = 1.56 x 10(-3); A-II/TG = 1.47 x 10(-3)) vs. saturated fat-fed animals (A-I/TG = 2.58 x 10(-3); A-II/TG = 2.77 x 10(-3)).	polyunsaturated fat	83-102	apolipoprotein A1	Homo sapiens	12-18
2329634-4	1990	Mean total mass of HDL2 was also 23.5% higher and concentration of apolipoprotein B was 5.4% lower on transfer to the polyunsaturated fat diet.	polyunsaturated fat	118-137	apolipoprotein B	Homo sapiens	67-83
6804585-9	1982	Chylomicron apoA-I/triglyceride and apoA-II/triglyceride mass ratios were lower in polyunsaturated fat-fed animals (A-I/TG = 1.56 x 10(-3); A-II/TG = 1.47 x 10(-3)) vs. saturated fat-fed animals (A-I/TG = 2.58 x 10(-3); A-II/TG = 2.77 x 10(-3)).	polyunsaturated fat	83-102	apolipoprotein A2	Homo sapiens	36-43
6804585-9	1982	Chylomicron apoA-I/triglyceride and apoA-II/triglyceride mass ratios were lower in polyunsaturated fat-fed animals (A-I/TG = 1.56 x 10(-3); A-II/TG = 1.47 x 10(-3)) vs. saturated fat-fed animals (A-I/TG = 2.58 x 10(-3); A-II/TG = 2.77 x 10(-3)).	polyunsaturated fat	83-102	NLR family pyrin domain containing 3	Homo sapiens	39-43
6804585-9	1982	Chylomicron apoA-I/triglyceride and apoA-II/triglyceride mass ratios were lower in polyunsaturated fat-fed animals (A-I/TG = 1.56 x 10(-3); A-II/TG = 1.47 x 10(-3)) vs. saturated fat-fed animals (A-I/TG = 2.58 x 10(-3); A-II/TG = 2.77 x 10(-3)).	polyunsaturated fat	83-102	NLR family pyrin domain containing 3	Homo sapiens	140-144
6804585-10	1982	It was concluded that: (1) dietary polyunsaturated fat significantly lowered plasma cholesterol, HDL, and apoA-I concentrations relative to saturated fat; (2) the HDL-lowering effect of the dietary polyunsaturated fat may be due to the combined effects of decreased apoprotein production by the intestine and increased HDL catabolism; and (3) in the blood, chylomicron apoA-I and A-II differ in their metabolic fates.-Parks, J. S., and L. L. Rudel.	polyunsaturated fat	35-54	apolipoprotein A1	Homo sapiens	106-112
6804585-10	1982	It was concluded that: (1) dietary polyunsaturated fat significantly lowered plasma cholesterol, HDL, and apoA-I concentrations relative to saturated fat; (2) the HDL-lowering effect of the dietary polyunsaturated fat may be due to the combined effects of decreased apoprotein production by the intestine and increased HDL catabolism; and (3) in the blood, chylomicron apoA-I and A-II differ in their metabolic fates.-Parks, J. S., and L. L. Rudel.	polyunsaturated fat	35-54	apolipoprotein A1	Homo sapiens	369-375
6804585-10	1982	It was concluded that: (1) dietary polyunsaturated fat significantly lowered plasma cholesterol, HDL, and apoA-I concentrations relative to saturated fat; (2) the HDL-lowering effect of the dietary polyunsaturated fat may be due to the combined effects of decreased apoprotein production by the intestine and increased HDL catabolism; and (3) in the blood, chylomicron apoA-I and A-II differ in their metabolic fates.-Parks, J. S., and L. L. Rudel.	polyunsaturated fat	35-54	NLR family pyrin domain containing 3	Homo sapiens	380-384
31247933-6	2019	Monounsaturated fat (MUFA) is preferable to polyunsaturated fat (PUFA) for fasting insulin and glucose lowering.	polyunsaturated fat	44-63	insulin	Homo sapiens	83-90
7135667-5	1982	The serum concentration of apolipoprotein (apo) A-I was directly correlated to the content of polyunsaturated fat and the ratio between polyunsaturated and saturated fatty acids in the triglycerides.	polyunsaturated fat	94-113	apolipoprotein A1	Homo sapiens	27-51
30465491-0	2020	Apolipoprotein E genotype moderates the association between dietary polyunsaturated fat and brain function: an exploration of cerebral glutamate and cognitive performance.	polyunsaturated fat	68-87	apolipoprotein E	Homo sapiens	0-16
30465491-1	2020	OBJECTIVE: To investigate the effect of Apolipoprotein E (APOE) genotype on the association between dietary polyunsaturated fat (PUFA), cognitive function, and cerebral glutamate.	polyunsaturated fat	108-127	apolipoprotein E	Homo sapiens	40-56
30465491-1	2020	OBJECTIVE: To investigate the effect of Apolipoprotein E (APOE) genotype on the association between dietary polyunsaturated fat (PUFA), cognitive function, and cerebral glutamate.	polyunsaturated fat	108-127	apolipoprotein E	Homo sapiens	58-62
7400846-3	1980	The serum immunoglobulins IgG1 and IgG2, but not IgM or IgA, increased in mice fed the polyunsaturated fat (PUF) diet as compared to the levels in those mice fed the saturated fat (SF) diet.	polyunsaturated fat	87-106	LOC105243590	Mus musculus	26-30
207739-10	1978	However, when compared with the saturated diet, the synthetic rate of apoA-I was reduced by 26% during polyunsaturated fat feeding.	polyunsaturated fat	103-122	apolipoprotein A1	Homo sapiens	70-76
190436-5	1977	Both the triglyceride production rate and the insulin response were significantly lower on a diet in carbohydrate and higher in polyunsaturated fat.	polyunsaturated fat	128-147	insulin	Homo sapiens	46-53
31298947-6	2020	High consumption of monounsaturated fat was significantly associated with a decreased risk of BCC (RR: 0.90, 95% CI: 0.85-0.96) and high level of polyunsaturated fat intake was potentially positively associated with SCC (RR: 1.19, 95% CI: 1.06-1.33).	polyunsaturated fat	146-165	serpin family B member 3	Homo sapiens	216-219
29193779-2	2018	In contrast, diets supplemented with polyunsaturated fat improve insulin sensitivity (SI) and reduce the risk for type 2 diabetes.	polyunsaturated fat	37-56	insulin	Homo sapiens	65-72
30347780-8	2018	Added sugar, saturated fat and polyunsaturated fat were positively related to serum TG, HDL-C, and DBP, respectively.	polyunsaturated fat	31-50	D-box binding PAR bZIP transcription factor	Homo sapiens	99-102
29636341-7	2018	Higher polyunsaturated fat intake was associated with risk of SCC [pooled HR for highest vs. lowest quintiles, 1.16; 95% confidence interval (CI), 1.05-1.28; Ptrend=0.001] and BCC (pooled HR, 1.06; 95% CI, 1.01-1.11; Ptrend=0.01).	polyunsaturated fat	7-26	serpin family B member 3	Homo sapiens	62-65
24682920-2	2014	The objective of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on Delta(3)Delta(2)-enoyl-CoA isomerase (ECI) in the liver and other tissues.	polyunsaturated fat	108-127	enoyl-CoA delta isomerase 1	Rattus norvegicus	131-167
24851712-3	2014	Soybean lines that are low in polyunsaturated fats were generated by introducing mutations in two fatty acid desaturase 2 genes (FAD2-1A and FAD2-1B), which in the seed convert the monounsaturated fat, oleic acid, to the polyunsaturated fat, linoleic acid.	polyunsaturated fat	30-49	omega-6 fatty acid desaturase	Glycine max	141-148
23337343-3	2013	We decide to investigate the role of polymorphism (G1359A) of (CNR1) gene on metabolic parameters and weight loss secondary to a high monounsaturated fat and high polyunsaturated fat hypocaloric diets in obese subjects.	polyunsaturated fat	163-182	cannabinoid receptor 1	Homo sapiens	63-67
24855375-1	2014	The aim of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on the mRNA expression of peroxisome-proliferator-activated receptor alpha (PPARalpha), peroxisome-proliferator-activated receptor gamma (PPARgamma), and mitochondrial Delta3Delta2-enoyl-CoA isomerase (ECI) in the liver.	polyunsaturated fat	102-121	peroxisome proliferator activated receptor alpha	Rattus norvegicus	198-207
24855375-1	2014	The aim of the study was to investigate the impact of a moderate zinc deficiency and a high intake of polyunsaturated fat on the mRNA expression of peroxisome-proliferator-activated receptor alpha (PPARalpha), peroxisome-proliferator-activated receptor gamma (PPARgamma), and mitochondrial Delta3Delta2-enoyl-CoA isomerase (ECI) in the liver.	polyunsaturated fat	102-121	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	260-269
24445122-9	2013	CONCLUSION: Subjects with C385C genotype of the FAAH showed an improvement on insulin and HOMA-R levels with a high polyunsaturated fat hypocaloric diet after weight loss during 3 months.	polyunsaturated fat	116-135	fatty acid amide hydrolase	Homo sapiens	48-52
24445122-9	2013	CONCLUSION: Subjects with C385C genotype of the FAAH showed an improvement on insulin and HOMA-R levels with a high polyunsaturated fat hypocaloric diet after weight loss during 3 months.	polyunsaturated fat	116-135	insulin	Homo sapiens	78-85
23601741-0	2013	Role of G308 promoter variant of tumor necrosis factor alpha gene on weight loss and metabolic parameters after a high monounsaturated versus a high polyunsaturated fat hypocaloric diets.	polyunsaturated fat	149-168	tumor necrosis factor	Homo sapiens	33-60
23601741-1	2013	BACKGROUND AND OBJECTIVE: The aim of our study was to investigate the influence of G-308 promoter variant of the tumor necrosis factor (TNF) alpha gene on metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diet in obese subjects.	polyunsaturated fat	239-258	tumor necrosis factor	Homo sapiens	113-146
23601741-7	2013	CONCLUSION: Carriers of the G-308G promoter variant of TNF alpha gene have a better metabolic response than A-308 obese with a high polyunsaturated fat hypocaloric diet.	polyunsaturated fat	132-151	tumor necrosis factor	Homo sapiens	55-64
23072901-2	2012	The aim of our study was to investigate the influence of Thr54 polymorphism in the FABP2 gene on weight loss and secondarily in cardiovascular risk factors and serum adipokine after an enriched polyunsaturated fat hypocaloric diet in obese patients.	polyunsaturated fat	194-213	fatty acid binding protein 2	Homo sapiens	83-88
23736006-1	2013	OBJECTIVE: The aim of our study was to investigate the role of Trp64Arg polymorphism of the beta 3-adrenergic receptor (beta 3-AR) gene on metabolic changes and weight loss secondary to a high monounsaturated fat versus a high polyunsaturated fat hypocaloric diet in obese subjects.	polyunsaturated fat	227-246	adrenoceptor beta 3	Homo sapiens	92-118
23736006-1	2013	OBJECTIVE: The aim of our study was to investigate the role of Trp64Arg polymorphism of the beta 3-adrenergic receptor (beta 3-AR) gene on metabolic changes and weight loss secondary to a high monounsaturated fat versus a high polyunsaturated fat hypocaloric diet in obese subjects.	polyunsaturated fat	227-246	adrenoceptor beta 3	Homo sapiens	120-129
23165529-0	2012	[Relation of -55CT polymorphism of UCP3 gene with weight loss and metabolic changes after a high polyunsaturated fat diet in obese patients].	polyunsaturated fat	97-116	uncoupling protein 3	Homo sapiens	35-39
23165534-6	2012	Besides, interactions between soy components, such as standard amino acids, polyunsaturated fat, and the isoflavonoid-enriched fraction, are believed to improve fatty acid oxidation in the liver parenchyma by increasing the expression of peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated genes, thus decreasing lipid accumulation in the liver.	polyunsaturated fat	76-95	peroxisome proliferator activated receptor alpha	Homo sapiens	238-286