PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
3798464-0	1986	Kinetic analysis of acetylcholinesterase inhibition by combinations of acephate and methamidophos.	acephate	71-79	acetylcholinesterase	Rattus norvegicus	20-40
3608937-6	1987	Similar changes occurred in rats exposed to 10 mg of acephate/kg.day; however, plasma cholinesterase and RBC acetylcholinesterase activities were inhibited.	acephate	53-61	butyrylcholinesterase	Rattus norvegicus	86-100
3608937-6	1987	Similar changes occurred in rats exposed to 10 mg of acephate/kg.day; however, plasma cholinesterase and RBC acetylcholinesterase activities were inhibited.	acephate	53-61	acetylcholinesterase	Rattus norvegicus	109-129
2729280-4	1989	Pesticides most frequently associated with cholinesterase depressions exceeding California threshold values included mevinphos (Phosdrin), oxydemeton methyl (Metasystox-R), methomyl (Lannate), and acephate (Orthene); these pesticides included organophosphates in toxicity categories I and II and one carbamate in toxicity category I.	acephate	207-214	butyrylcholinesterase	Homo sapiens	43-57
3798464-7	1986	It is also proposed that acephate prevented the initial competitive binding of methamidophos to the AChE active site and delayed the initial sequence of events essential for phosphorylation of AChE.	acephate	25-33	acetylcholinesterase	Rattus norvegicus	100-104
3798464-7	1986	It is also proposed that acephate prevented the initial competitive binding of methamidophos to the AChE active site and delayed the initial sequence of events essential for phosphorylation of AChE.	acephate	25-33	acetylcholinesterase	Rattus norvegicus	193-197
3798464-1	1986	Acephate pre-exposure provided protection against the inhibition of RBC and brain acetylcholinesterase (AChE), and plasma cholinesterase (ChE) activities in rats exposed to both acephate and methamidophos.	acephate	0-8	acetylcholinesterase	Rattus norvegicus	82-102
3798464-1	1986	Acephate pre-exposure provided protection against the inhibition of RBC and brain acetylcholinesterase (AChE), and plasma cholinesterase (ChE) activities in rats exposed to both acephate and methamidophos.	acephate	0-8	acetylcholinesterase	Rattus norvegicus	104-108
3798464-1	1986	Acephate pre-exposure provided protection against the inhibition of RBC and brain acetylcholinesterase (AChE), and plasma cholinesterase (ChE) activities in rats exposed to both acephate and methamidophos.	acephate	0-8	butyrylcholinesterase	Rattus norvegicus	88-102
3798464-1	1986	Acephate pre-exposure provided protection against the inhibition of RBC and brain acetylcholinesterase (AChE), and plasma cholinesterase (ChE) activities in rats exposed to both acephate and methamidophos.	acephate	0-8	butyrylcholinesterase	Rattus norvegicus	105-108
3798464-2	1986	In vitro addition of acephate to AChE prior to or with methamidophos also provided complete protection against AChE inhibition by methamidophos.	acephate	21-29	acetylcholinesterase	Rattus norvegicus	33-37
3798464-2	1986	In vitro addition of acephate to AChE prior to or with methamidophos also provided complete protection against AChE inhibition by methamidophos.	acephate	21-29	acetylcholinesterase	Rattus norvegicus	111-115
3798464-4	1986	Since acephate has greater affinity than does methamidophos for the AChE active site (Singh, A.K., Toxicol.	acephate	6-14	acetylcholinesterase	Rattus norvegicus	68-72
3798464-6	1986	Pharmacol., 81 (1985) 302), it is proposed that acephate provided protection by binding with the AChE active site and, therefore, preventing methamidophos from binding with the enzyme.	acephate	48-56	acetylcholinesterase	Rattus norvegicus	97-101
4060156-0	1985	Kinetic analysis of inhibition of brain and red blood cell acetylcholinesterase and plasma cholinesterase by acephate or methamidophos.	acephate	109-117	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-79
4060156-0	1985	Kinetic analysis of inhibition of brain and red blood cell acetylcholinesterase and plasma cholinesterase by acephate or methamidophos.	acephate	109-117	butyrylcholinesterase	Homo sapiens	65-79
4060156-2	1985	For brain samples, the bimolecular rate constant values (Ki) in the presence of acephate and methamidophos were 0.06 and 6.3 microM-1 X min-1, respectively.	acephate	80-88	CD59 molecule (CD59 blood group)	Homo sapiens	136-141
4060156-3	1985	The affinity (as measured by Ka values) of acephate was greater than that of methamidophos to both the AChE and the ChE active sites.	acephate	43-51	acetylcholinesterase (Cartwright blood group)	Homo sapiens	103-107
4060156-3	1985	The affinity (as measured by Ka values) of acephate was greater than that of methamidophos to both the AChE and the ChE active sites.	acephate	43-51	butyrylcholinesterase	Homo sapiens	104-107
4060156-5	1985	The Kp values in the presence of acephate and methamidophos for brain samples were 14.3 and 0.13 min-1, respectively.	acephate	33-41	CD59 molecule (CD59 blood group)	Homo sapiens	97-102
7154130-0	1982	Inhibitory effect of acephate (N-acetyl O, S-dimethyl thiophosphoramide) on serum cholinesterase--effect of acephate on cholinesterase.	acephate	21-29	butyrylcholinesterase	Homo sapiens	82-96
3975930-1	1985	Oral intubation of 50 and 100 mg/kg acephate inhibited brain acetylcholinesterase (AChE) activity by 45% and 56%, and reduced basal luteinizing hormone (LH) concentration by 29% and 25% after 4 h in white-footed mice (Peromyscus leucopus noveboracensis).	acephate	36-44	acetylcholinesterase	Mus musculus	83-87
3975930-2	1985	Dietary exposure to 25, 100, and 400 ppm acephate for 5 days substantially inhibited brain AChE activity, but did not affect plasma LH concentration.	acephate	41-49	acetylcholinesterase	Mus musculus	91-95
3989221-6	1985	The cholinesterase-inhibiting properties of acephate and methamidophos were compared in vitro to that of paraoxon, a known strong anticholinesterase.	acephate	44-52	butyrylcholinesterase	Rattus norvegicus	4-18
7154130-0	1982	Inhibitory effect of acephate (N-acetyl O, S-dimethyl thiophosphoramide) on serum cholinesterase--effect of acephate on cholinesterase.	acephate	108-116	butyrylcholinesterase	Homo sapiens	82-96
7154130-0	1982	Inhibitory effect of acephate (N-acetyl O, S-dimethyl thiophosphoramide) on serum cholinesterase--effect of acephate on cholinesterase.	acephate	108-116	butyrylcholinesterase	Homo sapiens	120-134
7154130-5	1982	Acephate, one of the organophosphorous insecticides, inhibited the activity of cholinesterase.	acephate	0-8	butyrylcholinesterase	Homo sapiens	79-93
7154130-7	1982	The minimum concentration of acephate inhibition of cholinesterase activity was at 2.5 mM.	acephate	29-37	butyrylcholinesterase	Homo sapiens	52-66
7154130-9	1982	The serum cholinesterase activity of workers who were exposed to acephate is not affected when the concentration of acephate in serum is less than 200 ppm.	acephate	65-73	butyrylcholinesterase	Homo sapiens	10-24
7154130-11	1982	The inhibitory effect of acephate on cholinesterase decreased after the incubation with S-9 mixture.	acephate	25-33	butyrylcholinesterase	Homo sapiens	37-51
7459456-0	1980	Inhibition of brain cholinesterase activity in forest birds and squirrels exposed to aerially applied acephate.	acephate	102-110	butyrylcholinesterase	Homo sapiens	20-34
7338949-7	1981	Brain ChE activities in ducklings that died were significantly different among pesticide treatments: fensulfothion greater than parathion greater than acephate greater than malathion (p less than or equal to 0.05).	acephate	151-159	LOW QUALITY PROTEIN: cholinesterase	Anas platyrhynchos	6-9
33013750-8	2020	Enzymes related to acephate and/or methamidophos biodegradation include phosphotriesterase, paraoxonase 1, and carboxylesterase.	acephate	19-27	paraoxonase 1	Homo sapiens	92-105
33970322-2	2021	OPH is capable of degrading a wide variety of OPs, but it has poor specificity to OPs with P-S bond, including acephate.	acephate	111-119	acylaminoacyl-peptide hydrolase	Homo sapiens	0-3
33970322-3	2021	Given that the binding site residues of OPH determine its substrate specificity, this study was carried out to find the best OPH mutants containing a single point mutation in the binding site that possess improved specificity to acephate.	acephate	229-237	acylaminoacyl-peptide hydrolase	Homo sapiens	40-43
33970322-3	2021	Given that the binding site residues of OPH determine its substrate specificity, this study was carried out to find the best OPH mutants containing a single point mutation in the binding site that possess improved specificity to acephate.	acephate	229-237	acylaminoacyl-peptide hydrolase	Homo sapiens	125-128
33970322-4	2021	Hence, we generated all possible mutant models and performed molecular docking of acephate with wild-type OPH (OPH-WT) and its mutants.	acephate	82-90	acylaminoacyl-peptide hydrolase	Homo sapiens	106-109
33970322-4	2021	Hence, we generated all possible mutant models and performed molecular docking of acephate with wild-type OPH (OPH-WT) and its mutants.	acephate	82-90	acylaminoacyl-peptide hydrolase	Homo sapiens	111-114
33970322-5	2021	After that, molecular dynamic (MD) simulations of OPH-WT and the best mutants, according to the docking results, were performed in both apo- and complex with acephate forms.	acephate	158-166	acylaminoacyl-peptide hydrolase	Homo sapiens	50-56
33970322-6	2021	Docking results signified that 51 out of 228 mutants possessed increased binding affinities to acephate, as compared to OPH-WT.	acephate	95-103	acylaminoacyl-peptide hydrolase	Homo sapiens	120-126
33970322-8	2021	MD simulations confirmed the stability of the three mutants in both apo- and complex with acephate forms and also showed that these formed more stable complexes with acephate, as compared to OPH-WT.	acephate	90-98	acylaminoacyl-peptide hydrolase	Homo sapiens	191-194
33970322-8	2021	MD simulations confirmed the stability of the three mutants in both apo- and complex with acephate forms and also showed that these formed more stable complexes with acephate, as compared to OPH-WT.	acephate	166-174	acylaminoacyl-peptide hydrolase	Homo sapiens	191-194
22778074-9	2014	Acephate induced an increase in glucose and corticosterone levels as well as in TAT and G6Pase activities.	acephate	0-8	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	88-94
30310664-0	2018	Chronic exposure to acephate triggers ROS-mediated injuries at organismal and sub-organismal levels of Drosophila melanogaster.	acephate	20-28	ros	Drosophila melanogaster	38-41
30310664-1	2018	The present study demonstrates ROS-mediated organismal and sub-organismal injuries in Drosophila melanogaster following chronic acephate exposure.	acephate	128-136	ros	Drosophila melanogaster	31-34
30310664-11	2018	Thus, the findings of the present study validate the fact that besides traditional cholinesterase inhibition, chronic sub-lethal exposure to acephate potentially induces ROS-mediated toxic responses in Drosophila.	acephate	141-149	ros	Drosophila melanogaster	170-173
25596135-10	2015	Acephate caused effects similar to those caused by paraoxon (non-neuropathic OP) and was only able to inhibit 70% of NTE activity at lethal concentrations.	acephate	0-8	patatin like phospholipase domain containing 6	Homo sapiens	117-120
25158275-0	2014	Pharmacokinetics and effects on serum cholinesterase activities of organophosphorus pesticides acephate and chlorpyrifos in chimeric mice transplanted with human hepatocytes.	acephate	95-103	butyrylcholinesterase	Mus musculus	38-52
25158275-4	2014	Approximately 70% inhibition of cholinesterase was evident in plasma of chimeric mice with humanized liver (which have higher serum cholinesterase activities than wild type mice) 1day after oral administrations of acephate.	acephate	214-222	butyrylcholinesterase	Mus musculus	32-46
25158275-4	2014	Approximately 70% inhibition of cholinesterase was evident in plasma of chimeric mice with humanized liver (which have higher serum cholinesterase activities than wild type mice) 1day after oral administrations of acephate.	acephate	214-222	butyrylcholinesterase	Mus musculus	132-146
27701059-6	2017	The sub-cellular toxic impacts of Acephate treatment became obvious from enhancement in activities of antioxidant enzymes (CAT by ~1.63 folds, SOD by ~1.32 folds), detoxifying enzymes (Cyp450 by ~1.99 folds and GST by ~1.34 folds), 2.1 times boost in HSP 70 expression, and inhibition of cholinesterase activity (by ~0.66 folds).	acephate	34-42	disembodied	Drosophila melanogaster	185-188
27701059-6	2017	The sub-cellular toxic impacts of Acephate treatment became obvious from enhancement in activities of antioxidant enzymes (CAT by ~1.63 folds, SOD by ~1.32 folds), detoxifying enzymes (Cyp450 by ~1.99 folds and GST by ~1.34 folds), 2.1 times boost in HSP 70 expression, and inhibition of cholinesterase activity (by ~0.66 folds).	acephate	34-42	Heat-shock-protein-70Ab	Drosophila melanogaster	251-257
24875908-3	2014	The binding abilities of pesticides to CAT followed the order: fenvalerate>deltamethrin>disulfoton>isofenphos-methyl>carbaryl>malathion>isocarbophos>dimethoate>dipterex>acephate>methomyl>methamidophos, which was generally similar to the order of determination sensitivity of pesticides.	acephate	196-204	catalase	Homo sapiens	39-42
22778074-10	2014	AChE activity was inhibited by acephate.	acephate	31-39	acetylcholinesterase	Rattus norvegicus	0-4
24001830-0	2014	Acetylcholinesterase based biosensor for monitoring of Malathion and Acephate in food samples: a voltammetric study.	acephate	69-77	acetylcholinesterase (Cartwright blood group)	Homo sapiens	0-20
24632376-0	2014	Duplication of acetylcholinesterase gene in diamondback moth strains with different sensitivities to acephate.	acephate	101-109	acetylcholinesterase	Plutella xylostella	15-35
24632376-1	2014	This study examined the acetylcholinesterase 1 gene (AChE1) in Plutella xylostella strains with different sensitivities to acephate.	acephate	123-131	acetylcholinesterase-like	Plutella xylostella	24-46
16563591-6	2006	The exposure to AChE inhibiting pesticides for the general population at P99.9, represented 33.6% of the ARfD as methamidophos and 70.2% ARfD as acephate.	acephate	145-153	acetylcholinesterase	Rattus norvegicus	16-20
23796225-0	2013	Molecular docking and QSAR studies: noncovalent interaction between acephate analogous and the receptor site of human acetylcholinesterase.	acephate	68-76	acetylcholinesterase (Cartwright blood group)	Homo sapiens	118-138
20390953-7	2010	From all pesticides tested, only acephate and methomyl showed a significant correlation (p < 0.01) between PEC values and inhibition cholinesterase activity of soil extracts.	acephate	33-41	butyrylcholinesterase	Homo sapiens	136-150
19118596-4	2009	In further experiment carried out to understand the etiology of the induced hyperglycemia, we observed that 2h exposure to acephate caused significant increase in blood glucose, plasma corticosterone (78%) and activities of two gluconeogenesis enzymes in liver viz., glucose-6-phosphatase (91%) and tyrosine aminotransferase (84%) compared to that in control.	acephate	123-131	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	267-288
11328714-4	2001	Acephate (Ace), like Met, is a poor inhibitor of AChE in vitro and has a comparable to Met insect toxicity in vivo.	acephate	0-8	acetylcholinesterase (Cartwright blood group)	Homo sapiens	49-53
20021020-2	2006	The aim of the study was to determine the IC50 concentration of the pesticides monocrotophos, chlorpyrifos, profenofos, and acephate as inhibitors of AChE.	acephate	124-132	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154
20021020-5	2006	The IC50 values for RBC-AChE were 0.12 muM, 0.25 muM, 0.35 muM, and 4.0 muM for chlorpyrifos, monocrotophos, profenofos, and acephate, respectively.	acephate	125-133	acetylcholinesterase (Cartwright blood group)	Homo sapiens	24-28
14694584-0	2002	[Comparison of the toxic effect of methamidophos and acephate on acetylcholinesterase].	acephate	53-61	acetylcholinesterase	Rattus norvegicus	65-85
14694584-3	2002	RESULTS: Acephate and methamidophos could directly inhibit AChE activities in human erythrocyte membrane and rat brain synatosomal membrane in dose- and time-dependent manners in vitro, and this effect was irreversible.	acephate	9-17	acetylcholinesterase (Cartwright blood group)	Homo sapiens	59-63
14694584-6	2002	When rats being administrated with acephate, there was 31.68% of inhibition on the brain stem, but no significant inhibition in other brain region was noticed, while methamidophos had a strong inhibitory effect on the activity of AChE in all brain regions, especially the cerebellum and brain-stem(71.51% and 61.85% respectively).	acephate	35-43	acetylcholinesterase	Rattus norvegicus	230-234
14694584-7	2002	CONCLUSION: Acephate and methamidophos could directly inhibit the AChE activities in vitro, but the inhibition degree was different.	acephate	12-20	acetylcholinesterase	Rattus norvegicus	66-70
15582210-0	2005	CYP superfamily perturbation by diflubenzuron or acephate in different tissues of CD1 mice.	acephate	49-57	CD1 antigen complex	Mus musculus	82-85
11328714-10	2001	The mammalian toxicity of Ace analogs may be due to interaction with an "allosteric" reaction center in the AChE.	acephate	26-29	acetylcholinesterase (Cartwright blood group)	Homo sapiens	108-112
11696925-2	2001	The neuropathy-target-esterase (NTE) inhibition data were either obtained from the literature for a number of OP compounds or were determined experimentally for methamidophos, acephate, coumaphos and EPN.	acephate	176-184	patatin like phospholipase domain containing 6	Homo sapiens	4-30
11696925-2	2001	The neuropathy-target-esterase (NTE) inhibition data were either obtained from the literature for a number of OP compounds or were determined experimentally for methamidophos, acephate, coumaphos and EPN.	acephate	176-184	patatin like phospholipase domain containing 6	Homo sapiens	32-35
2241237-10	1990	One subject who had urinary acephate excretion between 3 and 8 mg/L, showed slightly decreased values of PChE during exposure and of AChE after exposure.	acephate	28-36	acetylcholinesterase (Cartwright blood group)	Homo sapiens	133-137
9074804-1	1997	Acephate is an important systemic organophosphorus insecticide with toxicity attributed to bioactivation on metabolic conversion to methamidophos (or an oxidized metabolite thereof) which acts as an acetylcholinesterase (AChE) inhibitor.	acephate	0-8	acetylcholinesterase	Mus musculus	199-219
9074804-1	1997	Acephate is an important systemic organophosphorus insecticide with toxicity attributed to bioactivation on metabolic conversion to methamidophos (or an oxidized metabolite thereof) which acts as an acetylcholinesterase (AChE) inhibitor.	acephate	0-8	acetylcholinesterase	Mus musculus	221-225
2097819-17	1990	This study also indicated that the ED site in rat-AChE may be peripheral to the active site, and that the binding of acephate to this site prevented the phosphorylation by methamidophos of the rat-AChE.	acephate	117-125	acetylcholinesterase	Rattus norvegicus	197-201
12520917-1	2000	Acephate in the air was collected with polyurethane foamed plastics, desorbed with methanl, separated with a column 2% DEGS and determined by GC-FPD.	acephate	0-8	delta 4-desaturase, sphingolipid 1	Homo sapiens	119-123
9568380-2	1998	Me is a potent inhibitor, while Ac is a poor inhibitor of mammalian AChE (mAChE).	acephate	32-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	68-72
9568380-20	1998	This destabilizes the binding of Ac to the active center, resulting in reduced AChE phosphorylation.	acephate	33-35	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-83
2097819-5	1990	Acephate was a potent inhibitor of cockroach AChE, but a poor inhibitor of rat AChE.	acephate	0-8	acetylcholinesterase	Rattus norvegicus	45-49
2097819-5	1990	Acephate was a potent inhibitor of cockroach AChE, but a poor inhibitor of rat AChE.	acephate	0-8	acetylcholinesterase	Rattus norvegicus	79-83
2097819-7	1990	Acephate exhibited greater affinity for the cockroach-AChE than for the rat-AChE, and acephate phosphorylated the cockroach-AChE several times faster than the rat enzyme.	acephate	0-8	acetylcholinesterase	Rattus norvegicus	54-58
2097819-7	1990	Acephate exhibited greater affinity for the cockroach-AChE than for the rat-AChE, and acephate phosphorylated the cockroach-AChE several times faster than the rat enzyme.	acephate	0-8	acetylcholinesterase	Rattus norvegicus	76-80
2097819-7	1990	Acephate exhibited greater affinity for the cockroach-AChE than for the rat-AChE, and acephate phosphorylated the cockroach-AChE several times faster than the rat enzyme.	acephate	0-8	acetylcholinesterase	Rattus norvegicus	76-80
2097819-9	1990	Solubilization of AChE by Triton X-100 altered the kinetics of inhibition of rat AChE by acephate.	acephate	89-97	acetylcholinesterase	Rattus norvegicus	18-22
2097819-9	1990	Solubilization of AChE by Triton X-100 altered the kinetics of inhibition of rat AChE by acephate.	acephate	89-97	acetylcholinesterase	Rattus norvegicus	81-85
2097819-12	1990	The mechanism of acephate-cockroach AChE interaction was different than the mechanism of acephate-rat AChE interaction.	acephate	17-25	acetylcholinesterase	Rattus norvegicus	36-40
2097819-12	1990	The mechanism of acephate-cockroach AChE interaction was different than the mechanism of acephate-rat AChE interaction.	acephate	89-97	acetylcholinesterase	Rattus norvegicus	102-106
2097819-15	1990	It is also proposed that the ED site in cockroach-AChE may be situated in or adjacent to the active site and, therefore, acephate may be bound to the ED site such that the phosphate moiety of acephate interacts with the enzyme"s "esteratic" site.	acephate	121-129	acetylcholinesterase	Rattus norvegicus	50-54
2097819-15	1990	It is also proposed that the ED site in cockroach-AChE may be situated in or adjacent to the active site and, therefore, acephate may be bound to the ED site such that the phosphate moiety of acephate interacts with the enzyme"s "esteratic" site.	acephate	192-200	acetylcholinesterase	Rattus norvegicus	50-54
2097819-17	1990	This study also indicated that the ED site in rat-AChE may be peripheral to the active site, and that the binding of acephate to this site prevented the phosphorylation by methamidophos of the rat-AChE.	acephate	117-125	acetylcholinesterase	Rattus norvegicus	50-54
2284053-0	1990	Acetylcholinesterase and neuropathy target esterase in chickens treated with acephate.	acephate	77-85	acetylcholinesterase (Cartwright blood group)	Gallus gallus	0-20
2284053-0	1990	Acetylcholinesterase and neuropathy target esterase in chickens treated with acephate.	acephate	77-85	patatin like phospholipase domain containing 6	Gallus gallus	25-51
2284053-5	1990	Regression analyses indicated an ID50 (a dose that inhibits 50% of activity) for acephate inhibition of AChE of 10 mg/kg and an extrapolated ID50 for inhibition of NTE of 1300 mg/kg, almost twice the LD50.	acephate	81-89	acetylcholinesterase (Cartwright blood group)	Gallus gallus	104-108
2284053-9	1990	The results show acephate is a more potent inhibitor of AChE than it is of NTE in hens and suggest it would be difficult to administer a single dose of acephate sufficient to cause OPIDN without killing the animal.	acephate	17-25	acetylcholinesterase (Cartwright blood group)	Gallus gallus	56-60