PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2509026-0	1989	Calcium and protein kinase C enhance parathyroid hormone- and forskolin-stimulated adenylate cyclase in ROS 17/2.8 cells.	ros	104-107	parathyroid hormone	Rattus norvegicus	37-56
2509026-1	1989	Both parathyroid hormone (PTH)- and forskolin-stimulated adenylate cyclase activities in ROS 17/2.8 cells are enhanced by increasing the medium concentrations of CaCl2 from 10(-5) M to 3 x 10(-3) M. The ED50 for CaCl2 for both PTH- and forskolin-stimulated activities are similar.	ros	89-92	parathyroid hormone	Rattus norvegicus	5-24
2612198-1	1989	In the heterozygous mutant (rds/+) mice, receptor outer segments (ROS) are irregular in form and are shed as abnormally large phagosomes.	ros	66-69	peripherin 2	Mus musculus	28-31
2558749-0	1989	Calcium modulation of the parathyroid hormone-sensitive adenylate cyclase in ROS 17/2.8 cells: effects of N-(6-aminohexyl-5-Cl-naphthalene sulfonamide) (W-7) and trifluoperazine (TFP).	ros	77-80	parathyroid hormone	Rattus norvegicus	26-45
2592421-1	1989	In this report we demonstrate an increase in the steady-state level of bone sialoprotein (BSP) mRNA in rat calvaria and a rat osteosarcoma cell line (ROS 17/2.8) after treatment with the synthetic glucocorticoid, dexamethasone.	ros	150-153	integrin-binding sialoprotein	Rattus norvegicus	71-88
2592421-1	1989	In this report we demonstrate an increase in the steady-state level of bone sialoprotein (BSP) mRNA in rat calvaria and a rat osteosarcoma cell line (ROS 17/2.8) after treatment with the synthetic glucocorticoid, dexamethasone.	ros	150-153	integrin-binding sialoprotein	Rattus norvegicus	90-93
2477233-1	1989	We examined mechanisms of down-regulation of PTH receptors and desensitization of the PTH-stimulated increase in intracellular cAMP in clonal rat osteosarcoma cells, ROS 17/2.8.	ros	166-169	parathyroid hormone	Rattus norvegicus	86-89
2477233-5	1989	Treatment of ROS cells with pertussis toxin (PT; 10 ng/ml) for 12, 24, 48, and 72 h increased specific PTH binding by 21%, 28%, 35%, and 39%.	ros	13-16	parathyroid hormone	Rattus norvegicus	103-106
2612198-13	1989	These results show that ocular pigmentation may modify the circadian pattern of ROS disc shedding in the rds/+ retina.	ros	80-83	peripherin 2	Mus musculus	105-108
2791978-4	1989	Characterization of the factor(s) of PTH-stimulated osteoblast-like cell (ROS 17/2) suggests that the compound(s) is not prostaglandin (no inhibition by indomethacin; not extractable in diethylacetate).	ros	74-77	parathyroid hormone	Homo sapiens	37-40
2551642-0	1989	Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells.	ros	121-124	parathyroid hormone	Rattus norvegicus	28-47
2551642-1	1989	We and others have recently shown that amino terminal sequences of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), which share a 62% homology within the first 13 residues, bind to the same receptor on ROS 17/2.8 cells.	ros	228-231	parathyroid hormone	Rattus norvegicus	67-86
2551642-1	1989	We and others have recently shown that amino terminal sequences of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), which share a 62% homology within the first 13 residues, bind to the same receptor on ROS 17/2.8 cells.	ros	228-231	parathyroid hormone	Rattus norvegicus	88-91
2791978-10	1989	Sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis of [35S]methionine-labeled PTH-stimulated ROS culture supernatants reveals relatively increased secretion of proteins with these approximate molecular radii.	ros	109-112	parathyroid hormone	Homo sapiens	94-97
2645866-0	1989	Internalization and degradation of insulin by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells.	ros	73-76	insulin	Homo sapiens	35-42
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	ros	14-17	parathyroid hormone	Rattus norvegicus	29-32
2537172-8	1989	Conversely, chronic treatment of ROS cells with PTH did not deplete PKC.	ros	33-36	parathyroid hormone	Rattus norvegicus	48-51
2537172-9	1989	In addition, chronic treatment of ROS cells with PTH inhibited the responsiveness of PKC activity to subsequent acute PTH challenge, but not to acute PMA challenge, suggesting specific desensitization of this response by PTH.	ros	34-37	parathyroid hormone	Rattus norvegicus	49-52
2537172-9	1989	In addition, chronic treatment of ROS cells with PTH inhibited the responsiveness of PKC activity to subsequent acute PTH challenge, but not to acute PMA challenge, suggesting specific desensitization of this response by PTH.	ros	34-37	parathyroid hormone	Rattus norvegicus	118-121
2537172-9	1989	In addition, chronic treatment of ROS cells with PTH inhibited the responsiveness of PKC activity to subsequent acute PTH challenge, but not to acute PMA challenge, suggesting specific desensitization of this response by PTH.	ros	34-37	parathyroid hormone	Rattus norvegicus	118-121
2763877-0	1989	Stimulation of inositol phosphate formation in ROS 17/2.8 cell membranes by guanine nucleotide, calcium, and parathyroid hormone.	ros	47-50	parathyroid hormone	Rattus norvegicus	109-128
2763877-2	1989	We sought to examine this potential action of PTH by assessing the formation of inositol phosphates in PTH-sensitive ROS 17/2.8 cells.	ros	117-120	parathyroid hormone	Rattus norvegicus	46-49
2763877-2	1989	We sought to examine this potential action of PTH by assessing the formation of inositol phosphates in PTH-sensitive ROS 17/2.8 cells.	ros	117-120	parathyroid hormone	Rattus norvegicus	103-106
2763877-10	1989	The results demonstrate that inositol phosphate formation can be stimulated directly in a membrane preparation of ROS cells by GTP gamma S, calcium ion, and PTH and that the enzyme mediating this activity, phospholipase C, is regulated by a guanine nucleotide binding protein.	ros	114-117	parathyroid hormone	Rattus norvegicus	157-160
2537172-11	1989	Pretreatment of ROS cells with PTH resulted in a transient decrease in the phosphorylation of these cytosolic proteins by PKC.	ros	16-19	parathyroid hormone	Rattus norvegicus	31-34
2537172-13	1989	These data suggest a potential role for PKC in the mechanism of action of PTH in ROS cells.	ros	81-84	parathyroid hormone	Rattus norvegicus	74-77
2855194-0	1988	Glucocorticoids increase parathyroid hormone receptors in rat osteoblastic osteosarcoma cells (ROS 17/2).	ros	95-98	parathyroid hormone	Rattus norvegicus	25-44
2643512-6	1989	Treatment of ROS cells with PTH or lipopolysaccharide (LPS) caused a dose-dependent increase in the secretion of this mitogenic activity.	ros	13-16	parathyroid hormone	Rattus norvegicus	28-31
2643512-10	1989	These findings suggest that PTH- and LPS-treated ROS cells secrete a T cell mitogenic activity which, by functional, serological, and biochemical criteria, is indistinguishable from GM CSF.	ros	49-52	parathyroid hormone	Rattus norvegicus	28-31
2624828-1	1989	Transforming growth factor beta (TGF-beta) was tested for its ability to stimulate a chemotactic response in two clonal rat osteosarcoma (ROS) cell lines, 17/2 and 25/1.	ros	138-141	transforming growth factor, beta 1	Rattus norvegicus	33-41
2624828-4	1989	In serum-free media, the maximal chemotactic response to TGF-beta occurred at 5 fg/mL for both the ROS 17/2 and 25/1 cells.	ros	99-102	transforming growth factor, beta 1	Rattus norvegicus	57-65
2691200-4	1989	Inhibition of osteocalcin expression by TGF beta in the rat osteoblastic osteosarcoma, ROS 17/2.8 cells, occurs at least in part through transcriptional control.	ros	87-90	bone gamma-carboxyglutamate protein	Rattus norvegicus	14-25
2691200-4	1989	Inhibition of osteocalcin expression by TGF beta in the rat osteoblastic osteosarcoma, ROS 17/2.8 cells, occurs at least in part through transcriptional control.	ros	87-90	transforming growth factor, beta 1	Rattus norvegicus	40-48
2508122-10	1989	An increase in LTC4 occurs in the neural retina after Ca+ ionophore stimulation and an increase in LTC4 released from retinal pigment epithelium occurs after light onset before massive shedding, suggesting an involvement of 5-lipoxygenase metabolites in the initial steps of ROS phagocytosis.	ros	275-278	arachidonate 5-lipoxygenase	Homo sapiens	224-238
2848035-1	1988	Synthetic peptides corresponding to the amino-terminal region of the human parathyroid hormone-related peptide (hPTHrp) were used to characterize the interaction of hPTHrp with parathyroid hormone (PTH) receptors in clonal rat osteosarcoma cells (ROS 17/2.8).	ros	247-250	parathyroid hormone	Homo sapiens	75-94
2848035-6	1988	The binding capacity and affinity of receptors in ROS cells were strikingly similar for hPTHrp and PTH.	ros	50-53	parathyroid hormone	Homo sapiens	89-92
2848035-8	1988	The data indicate that hPTHrp and PTH, their amino-terminal fragments at least, interact with the identical receptors with regard to affinity, capacity, specificity, and physicochemical characteristics in osteoblastic ROS 17/2.8 cells.	ros	218-221	parathyroid hormone	Rattus norvegicus	24-27
2831022-1	1988	PTH receptors on two stable clonal rat osteosarcoma cell lines, ROS 17/2 and ROS 17/2.8, were characterized using an HPLC-purified, synthetic, sulfur-free, radioiodinated analog of bovine PTH, [Nle8,Nle18,Tyr,34]bovine PTH-(1-34)amide.	ros	64-67	parathyroid hormone	Rattus norvegicus	0-3
2456915-1	1988	Glucocorticoids increase and 1,25-dihydoxyvitamin D3 [1,25-(OH)2D3] decreases the activity of PTH-responsive adenylate cyclase, altering intracellular cAMP in a rat osteoblast-like cell line (ROS 17/2.8).	ros	192-195	parathyroid hormone	Rattus norvegicus	94-97
2456915-3	1988	Pretreatment of ROS cells for 2 days with the glucocorticoid triamcinolone acetonide (TRM), shifted the dose-response curve for PKA activation by PTH upward compared to the control value.	ros	16-19	parathyroid hormone	Rattus norvegicus	146-149
2456335-0	1988	High affinity human IFN-gamma-binding capacity is encoded by a single receptor gene located in proximity to c-ros on human chromosome region 6q16 to 6q22.	ros	110-113	interferon gamma	Homo sapiens	20-29
2837457-0	1988	The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.	ros	165-168	parathyroid hormone	Rattus norvegicus	4-23
2837457-0	1988	The parathyroid hormone-like peptide associated with humoral hypercalcemia of malignancy and parathyroid hormone bind to the same receptor on the plasma membrane of ROS 17/2.8 cells.	ros	165-168	parathyroid hormone	Rattus norvegicus	93-112
2831022-1	1988	PTH receptors on two stable clonal rat osteosarcoma cell lines, ROS 17/2 and ROS 17/2.8, were characterized using an HPLC-purified, synthetic, sulfur-free, radioiodinated analog of bovine PTH, [Nle8,Nle18,Tyr,34]bovine PTH-(1-34)amide.	ros	77-80	parathyroid hormone	Rattus norvegicus	0-3
2831022-5	1988	Both ROS 17/2 and 17/2.8 have a single class of saturable, high affinity PTH binding sites that, by kinetic analysis and Scatchard analysis of saturation and competition studies, has a dissociation constant (Kd) of 0.8-1.4 nM.	ros	5-8	parathyroid hormone	Rattus norvegicus	73-76
2831022-7	1988	A close correlation was found between the binding of PTH agonists to their receptors in ROS 17/2 cells with their relative biological potencies as measured by stimulation of adenylate cyclase in plasma membranes prepared from these cells.	ros	88-91	parathyroid hormone	Rattus norvegicus	53-56
2831022-8	1988	Prolonged treatment of ROS 17/2 and 17/2.8 cells with PTH agonists results in a dose- and time-dependent decrease of available cell-surface binding sites, without alterations in Kd.	ros	23-26	parathyroid hormone	Rattus norvegicus	54-57
2831022-12	1988	Treatment of ROS 17/2 cells with PTH agonists results in a dose- and time-dependent decrease of PTH-stimulated adenylate cyclase.	ros	13-16	parathyroid hormone	Rattus norvegicus	33-36
2831022-12	1988	Treatment of ROS 17/2 cells with PTH agonists results in a dose- and time-dependent decrease of PTH-stimulated adenylate cyclase.	ros	13-16	parathyroid hormone	Rattus norvegicus	96-99
2831022-14	1988	Future studies with these stable ROS cell lines should permit detailed analysis of the biochemical mechanisms underlying homologous and heterologous regulation of PTH receptors and desensitization and sensitization of the adenylate cyclase response.	ros	33-36	parathyroid hormone	Rattus norvegicus	163-166
2830317-6	1988	Thus, in addition to similar dose-response curves for adenylate cyclase stimulation, both HCF and PTH produced identical postreceptor effects in ROS 17/2.8 cells.	ros	145-148	parathyroid hormone	Rattus norvegicus	98-101
2831208-2	1988	The purified analogue, NAP-NlePTH, is a fully active agonist in three different ROS 17/2.8 cell bioassays: 1) specific binding to saturable PTH receptors; 2) stimulation of cyclic AMP accumulation; and 3) inhibition of cellular alkaline phosphatase activity; this analogue gave dose response curves parallel to and 25-33% as potent as its parent molecule, NlePTH.	ros	80-83	parathyroid hormone	Rattus norvegicus	30-33
2831208-11	1988	Our data, using a highly purified photoactive derivative of PTH, having carefully defined chemical and biological properties, show a plasma membrane component of Mr = 80,000 in ROS 17/2.8 cells that possesses the affinity, binding capacity, and physiological characteristics of the PTH receptor.	ros	177-180	parathyroid hormone	Rattus norvegicus	60-63
2831208-11	1988	Our data, using a highly purified photoactive derivative of PTH, having carefully defined chemical and biological properties, show a plasma membrane component of Mr = 80,000 in ROS 17/2.8 cells that possesses the affinity, binding capacity, and physiological characteristics of the PTH receptor.	ros	177-180	parathyroid hormone	Rattus norvegicus	282-285
2831209-1	1988	In the preceding article, we described physicochemical and kinetic properties of parathyroid hormone (PTH) receptors in clonal rat osteosarcoma cells (ROS 17/2.8) using photoaffinity ligand labeling and showed that the physiologically relevant receptor-ligand complex has an apparent Mr = 80,000.	ros	151-154	parathyroid hormone	Rattus norvegicus	81-100
2831209-1	1988	In the preceding article, we described physicochemical and kinetic properties of parathyroid hormone (PTH) receptors in clonal rat osteosarcoma cells (ROS 17/2.8) using photoaffinity ligand labeling and showed that the physiologically relevant receptor-ligand complex has an apparent Mr = 80,000.	ros	151-154	parathyroid hormone	Rattus norvegicus	102-105
2831209-8	1988	PTH receptors on ROS 17/2.8 cells appear to be monomeric plasma membrane glycoproteins with an apparent Mr of 80,000 which contain a Mr = 59,000 polypeptide backbone and a polymeric arrangement of N-acetylglucosamine with N-acetylneuraminic acid as major terminal sugar residues.	ros	17-20	parathyroid hormone	Rattus norvegicus	0-3
2854747-2	1986	Pertussis toxin catalyzed ADP-ribosylation of Gi alpha in ROS cells increased agonist (PTH and isoproterenol)-stimulated, but not basal, cAMP production.	ros	58-61	parathyroid hormone	Rattus norvegicus	87-90
3422431-2	1988	To study the structure, function, and expression of ALP, a full-length cDNA of rat ALP (2415 bases) was isolated from a ROS 17/2.8 osteosarcoma cell lambda gt10 cDNA library.	ros	120-123	alkaline phosphatase, placental	Homo sapiens	83-86
3422431-9	1988	Furthermore, hybridization patterns derived from Southern blot analysis of rat chromosomal DNA offered molecular evidence that the ALP expressed in ROS 17/2.8 osteosarcoma and various rat tissues, excluding the intestine, is the product of the same single copy gene.	ros	148-151	alkaline phosphatase, placental	Homo sapiens	131-134
2824416-3	1987	The conditioned medium of EC-GI cells contained potent bone resorbing activity which stimulated cyclic AMP production in parathyroid hormone (PTH)-responsive osteoblast-like cells (ROS 17/2.8).	ros	181-184	parathyroid hormone	Homo sapiens	121-140
3021431-2	1986	PTH and 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] inhibited collagen synthesis in ROS 17/2 cells in a time- and dose-dependent manner.	ros	80-83	parathyroid hormone	Rattus norvegicus	0-3
3013322-1	1986	The influence of 1,25-dihydroxyvitamin D-3 on the cAMP response to parathyroid hormone was studied in the osteoblast-like rat osteosarcoma cells ROS 17/2.8.	ros	145-148	parathyroid hormone	Rattus norvegicus	67-86
3009162-1	1986	Treatment of ROS 17/2.8 cells with dexamethasone (dex) increases (-)isoproterenol (ISO)-, PTH-, cholera toxin-, guanine nucleotide-, NaF-, and forskolin-stimulated adenylate cyclase activity.	ros	13-16	parathyroid hormone	Rattus norvegicus	90-93
3257212-7	1988	This is only the second example of a bone matrix protein whose synthesis is dramatically increased by vitamin D, the first being the 6-fold stimulation of BGP synthesis by 1,25(OH)2D3 in ROS 17/2 cells.	ros	187-190	bone gamma-carboxyglutamate protein	Rattus norvegicus	155-158
3480288-1	1987	TGF beta 1 from porcine platelets increased alkaline phosphatase (AP) activity in the rat osteoblastic cell line ROS 17/2.8 about three-fold.	ros	113-116	transforming growth factor, beta 1	Rattus norvegicus	0-10
3484302-10	1987	We conclude that, although both triamcinolone acetate and retinoic acid increase the 1,25-dihydroxyvitamin D3 stimulation of BGP secretion by ROS 17/2 cells, they have different effects on the regulation of collagen production.	ros	142-145	bone gamma-carboxyglutamate protein	Rattus norvegicus	125-128
2821716-0	1987	A highly sensitive bioassay for PTH using ROS 17/2.8 subclonal cells.	ros	42-45	parathyroid hormone	Rattus norvegicus	32-35
2821716-1	1987	A highly sensitive bioassay for PTH was developed by using rat osteosarcoma cells (ROS 17/2.8).	ros	83-86	parathyroid hormone	Rattus norvegicus	32-35
2821716-2	1987	By limiting dilution, ROS cells were subcloned and the subclonal cell line (ROS 17/2.8-5) most responsive to PTH was selected.	ros	76-79	parathyroid hormone	Rattus norvegicus	109-112
2821716-3	1987	When subconfluent ROS 17/2.8-5 cells were treated with hydrocortisone for 3 days and then incubated with PTH, the cAMP response was significant at 10-40 ng/l hPTH (1-34) (4 approximately 16 X 10(-12) mol/l).	ros	18-21	parathyroid hormone	Rattus norvegicus	105-108
2821716-3	1987	When subconfluent ROS 17/2.8-5 cells were treated with hydrocortisone for 3 days and then incubated with PTH, the cAMP response was significant at 10-40 ng/l hPTH (1-34) (4 approximately 16 X 10(-12) mol/l).	ros	18-21	parathyroid hormone	Homo sapiens	158-162
3474142-9	1987	The data suggest that TGF beta stimulates expression of the osteoblastic phenotype in ROS 17/2.8 cells and that TGF beta may be an important regulator of local bone remodeling.	ros	86-89	transforming growth factor, beta 1	Rattus norvegicus	22-30
3455155-3	1987	A previous study has suggested that the potency of one human tumor-derived ACSF, expressed in PTH equivalents, was 30-fold higher in the ROS assay than in the RAC assay, but no study has directly compared all three bioassays using a single PTH standard and a single ACSF preparation.	ros	137-140	parathyroid hormone	Homo sapiens	94-97
3937588-3	1985	PTH stimulated CKBB in the osteoblast-like clone ROS 17/2; 1 alpha,25(OH)2D3 inhibited this activity while PGE2, CT and 24R,25(OH)2D3 had no significant effect.	ros	49-52	parathyroid hormone	Rattus norvegicus	0-3
2578454-8	1985	The data suggest that GC acts strongly on or near the PTH receptor-Ns complex in ROS 17/2.8 and to a lesser degree on the Ns-C interaction.	ros	81-84	parathyroid hormone	Rattus norvegicus	54-57
3877051-1	1985	A biosynthetic precursor to rat bone gamma-carboxyglutamic acid protein (BGP) was isolated from warfarin-treated ROS 17/2 osteosarcoma cells by antibody affinity chromatography followed by reverse phase high performance liquid chromatography.	ros	113-116	bone gamma-carboxyglutamate protein	Rattus norvegicus	73-76
2992916-12	1985	These studies suggest that PTH binds to ROS 17/2.8 cells by sites carboxy-terminal (C-terminal) to position 34, in addition to sites within the amino-terminal portion of the hormone molecule; 72% of the binding of intact hormone to these cells was to the C-terminal 35-84 region of the PTH molecule.	ros	40-43	parathyroid hormone	Rattus norvegicus	27-30
2578454-1	1985	To study regulation of the parathyroid hormone (PTH)-responsive adenylate cyclase of osteoblast-like cells by 1,25-dihydroxyvitamin D (1,25(OH)2D), cAMP levels and adenylate cyclase activity were assayed in the hormone-responsive ROS 17/2.8 rat osteosarcoma cell line.	ros	230-233	parathyroid hormone	Rattus norvegicus	27-46
33872694-5	2021	Knockdown of SIRT3 gene in GBC cell lines induced mitochondrial respiration and energy metabolism, but inhibited oxidative ROS.	ros	123-126	sirtuin 3	Homo sapiens	13-18
2578454-1	1985	To study regulation of the parathyroid hormone (PTH)-responsive adenylate cyclase of osteoblast-like cells by 1,25-dihydroxyvitamin D (1,25(OH)2D), cAMP levels and adenylate cyclase activity were assayed in the hormone-responsive ROS 17/2.8 rat osteosarcoma cell line.	ros	230-233	parathyroid hormone	Rattus norvegicus	48-51
6279255-7	1982	The two hormones stimulated ROS 17/2 adenylate cyclase, albeit at higher concentrations: Km values were 13 nM for PTH (1-34) and 16 nM for isoproterenol.	ros	28-31	parathyroid hormone	Rattus norvegicus	114-117
6279255-9	1982	These findings further document the osteoblastic properties of the ROS 17/2 osteosarcoma cell line, suggest that PTH inhibition of alkaline phosphatase represents a physiological response to the hormone in these cells, and implicate cyclic AMP as a mediator of this PTH effect.	ros	67-70	parathyroid hormone	Rattus norvegicus	113-116
33845232-4	2021	Further mechanistic study indicated that compound 40 inhibited the NLRP3 inflammasome activation via suppressing ROS production.	ros	113-116	NLR family pyrin domain containing 3	Homo sapiens	67-72
6086291-1	1984	Treatment of ROS 17/2.8 osteosarcoma-derived cells with dexamethasone potentiates the PTH stimulation of adenylate cyclase in these cells, yielding a detectable response to as little as 10 pM PTH.	ros	13-16	parathyroid hormone	Rattus norvegicus	86-89
6086291-1	1984	Treatment of ROS 17/2.8 osteosarcoma-derived cells with dexamethasone potentiates the PTH stimulation of adenylate cyclase in these cells, yielding a detectable response to as little as 10 pM PTH.	ros	13-16	parathyroid hormone	Rattus norvegicus	192-195
6429273-5	1984	A microspectrophotometer is used to examine the properties of rhodopsin in the two ends of the toad ROS.	ros	100-103	rhodopsin	Homo sapiens	62-71
33872833-10	2021	MTM1 knockout did not afford resistance to excess zinc through an effect mediated through an influence on levels of ROS.	ros	116-119	Mtm1p	Saccharomyces cerevisiae S288C	0-4
33932472-4	2021	Using Caco-2 as a cell model of the intestinal epithelial barrier (the first line of defense against mycotoxins), we showed that a strong production of ROS-dependent CXCL17 was triggered by mycotoxins via p38 and JNK pathways.	ros	152-155	mitogen-activated protein kinase 14	Homo sapiens	205-208
33932472-4	2021	Using Caco-2 as a cell model of the intestinal epithelial barrier (the first line of defense against mycotoxins), we showed that a strong production of ROS-dependent CXCL17 was triggered by mycotoxins via p38 and JNK pathways.	ros	152-155	mitogen-activated protein kinase 8	Homo sapiens	213-216
33722737-9	2021	Moreover, under the influence of TCS, the expression of iNOS was increased and at the same time the expression of nNOS was decreased, which was probably caused by high levels of ROS.	ros	178-181	nitric oxide synthase 2, inducible	Mus musculus	56-60
33913175-2	2021	We found that neuronal IFN-beta is indispensable for mitochondrial homeostasis and metabolism, sustaining ATP levels and preventing excessive ROS by controlling mitochondrial fission.	ros	142-145	IFN1@	Homo sapiens	23-31
32838607-5	2021	Knockdown of miR-1225-5p elevates ROS level via regulating Keap1/Nrf2 pathway.	ros	34-37	kelch like ECH associated protein 1	Homo sapiens	59-64
32838607-5	2021	Knockdown of miR-1225-5p elevates ROS level via regulating Keap1/Nrf2 pathway.	ros	34-37	NFE2 like bZIP transcription factor 2	Homo sapiens	65-69
33635505-9	2021	In summary, the results of this study indicate that low concentrations of (+)-usnic acid activate Nrf2 transcription factor, most probably as a result of ROS accumulation, but do not lead to FaDu hypopharyngeal carcinoma cells death.	ros	154-157	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
34060992-12	2021	CNPY2 overexpression reduced the accumulation of ROS and mitochondria dysfunction in neurons.	ros	49-52	canopy FGF signaling regulator 2	Mus musculus	0-5
34020396-7	2021	Our results indicate that MV with HTV caused the TLR4/TRAF6/NOX2 signaling pathway activation and production of large amounts of ROS, which led to ER stress and NF-kappaB mediated inflammation in VILI.	ros	129-132	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	161-170
34034133-4	2021	It could activate the ROS production in a NQO1-dependent manner, arrest tumor cell cycle at G0/G1 phase, promote tumor cell apoptosis, and decrease the mitochondrial membrane potential.	ros	22-25	NAD(P)H quinone dehydrogenase 1	Homo sapiens	42-46
34011928-0	2021	Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis.	ros	130-133	NLR family pyrin domain containing 3	Homo sapiens	134-139
34022514-6	2021	The results showed that heat stress up-regulated the HSP70 and HSP90 expression both in mRNA and protein, enhanced ROS accumulation, increased malondialdehyde (MDA) content, reduced the superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity, significantly increased the expression of caspase-3 and upregulated the ratio of Bax/Bcl-2 and ultimately lead to oxidative stress and apoptosis in MAC-T cells.	ros	115-118	heat shock 70 kDa protein 1B	Bos taurus	53-58
34000515-9	2021	RESULTS: In this study, we determined that FAC can induce a decrease in foam cell activity rather than macrophage activity, increase lipid ROS levels, decrease GPX4 expression and inhibit SIRT1 expression, and increase IL-1beta and IL-18 levels.	ros	139-142	FA complementation group C	Homo sapiens	43-46
34049220-10	2021	ERK, AMPK, and ROS pathways mediate the Nrf2 activation.	ros	15-18	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
34049220-11	2021	However, Nrf2 knockdown suppressed Pt"s antioxidant ability leading to uncontrolled ROS and alpha-MSH levels after UVA-irradiation suggested the essentiality of the Nrf2 pathway.	ros	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
34001853-0	2021	SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis.	ros	67-70	sirtuin 3	Homo sapiens	0-5
34001853-0	2021	SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis.	ros	67-70	catalase	Homo sapiens	49-57
34001853-7	2021	Functionally, ROS accumulation in CLL cells activated the AXL survival axis while upregulated SIRT3, suggesting that CLL cells rapidly remove highly reactive O2- to avoid its cytotoxic effect but maintain increased H2O2-level to promote cell survival.	ros	14-17	sirtuin 3	Homo sapiens	94-99
33960631-4	2021	Here, we found that the blue LED irradiation significantly suppressed the proliferation, migration and invasion of human OS cells, while we observed blue LED irradiation increased ROS production through increased NADPH oxidase enzymes NOX2 and NOX4, as well as decreased Catalase (CAT) expression levels.	ros	180-183	catalase	Homo sapiens	271-279
34045966-4	2021	Meanwhile, CD13 can activate NRF1 and up-regulate ROS scavenging genes transcription, such as SOD1, GPX1, GPX2 and GPX3, leading to down-regulation of intracellular ROS level and reducing the sensitivity of cells to chemotherapy agent.	ros	50-53	superoxide dismutase 1	Homo sapiens	94-98
34045966-4	2021	Meanwhile, CD13 can activate NRF1 and up-regulate ROS scavenging genes transcription, such as SOD1, GPX1, GPX2 and GPX3, leading to down-regulation of intracellular ROS level and reducing the sensitivity of cells to chemotherapy agent.	ros	50-53	glutathione peroxidase 3	Homo sapiens	115-119
34045966-4	2021	Meanwhile, CD13 can activate NRF1 and up-regulate ROS scavenging genes transcription, such as SOD1, GPX1, GPX2 and GPX3, leading to down-regulation of intracellular ROS level and reducing the sensitivity of cells to chemotherapy agent.	ros	165-168	superoxide dismutase 1	Homo sapiens	94-98
33377976-0	2021	Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress.	ros	52-55	sirtuin 3	Homo sapiens	0-5
33377976-0	2021	Sirt3 is critical for p53-mediated ferroptosis upon ROS-induced stress.	ros	52-55	tumor protein p53	Homo sapiens	22-25
33990669-12	2021	By gene silencing of HIF-1alpha and miR-210 the expression of PDHA1 was upregulated while that of MITF-M was downregulated, yielding acceleration of mitochondrial respiratory activity and thus elimination of ROS.	ros	208-211	hypoxia inducible factor 1 subunit alpha	Homo sapiens	21-31
33990669-14	2021	Based on the results of measurements of mitochondrial resipiratory activity, ROS production, and changes in the metabolites obtained in cells under the observed conditions, we concluded that silencing of HIF-1alpha and miR-210 yields apoptosis and, ultimately, apoptotic cell death in A375 melanoma cells.	ros	77-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	204-214
33991932-7	2021	Dh404 activated expression of Nrf2 decreased ROS level, increased HO-1 expression, ameliorated activity of the antioxidant enzyme, inhibited Cr (VI) increase of SREBP1, FAS level, and reduction of G6P and GLUT2.	ros	45-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
33960631-4	2021	Here, we found that the blue LED irradiation significantly suppressed the proliferation, migration and invasion of human OS cells, while we observed blue LED irradiation increased ROS production through increased NADPH oxidase enzymes NOX2 and NOX4, as well as decreased Catalase (CAT) expression levels.	ros	180-183	catalase	Homo sapiens	281-284
33737411-12	2021	CONCLUSION: We suggest that in OSAS, IH increases endothelial permeability in OSAS by inducing VE-Cadherin cleavage through ROS production and activation of HIF-1, VEGF and tyrosine kinase pathways.	ros	124-127	cadherin 5	Homo sapiens	95-106
33288900-6	2021	This regulation is mechanistically attributed to DNA hydroxymethylation fostered WDR76 interaction with LSH and increased ratio of DCAF8 to WDR76 for antagonistic LSH association accompanying decreased DNA oxidation along with ROS overproduction.	ros	227-230	DDB1 and CUL4 associated factor 8	Homo sapiens	131-136
33984806-6	2021	Compound 4 (IC50/A549 = 2.4 +- 0.6 muM) showed potent antitumor activity against NQO1-rich cancer cells through ROS generation via NQO1-mediated redox cycling.	ros	112-115	NAD(P)H quinone dehydrogenase 1	Homo sapiens	131-135
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	abl interactor 1	Homo sapiens	59-63
33644987-6	2021	The released beta-Lap generates ROS to induce tumor cell apoptosis under the catalysis of the tumor cell over-expressed NAD(P)H-quinone oxidoreductase-1 (NQO1) enzyme.	ros	32-35	NAD(P)H quinone dehydrogenase 1	Homo sapiens	120-152
33644987-6	2021	The released beta-Lap generates ROS to induce tumor cell apoptosis under the catalysis of the tumor cell over-expressed NAD(P)H-quinone oxidoreductase-1 (NQO1) enzyme.	ros	32-35	NAD(P)H quinone dehydrogenase 1	Homo sapiens	154-158
33615888-12	2021	In CnAalpha-/- renal fibroblasts, NFkappaB inhibition prevented Nox2 upregulation and ROS generation.	ros	86-89	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	34-42
33615888-13	2021	CONCLUSIONS: These findings indicate that 1) CnAalpha loss stimulates Nox2 upregulation, 2) NFkappaB is a novel CnAalpha-regulated transcription factor and 3) NFkappaB mediates CnAalpha-induced Nox2 and ROS upregulation.	ros	203-206	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	92-100
33615888-13	2021	CONCLUSIONS: These findings indicate that 1) CnAalpha loss stimulates Nox2 upregulation, 2) NFkappaB is a novel CnAalpha-regulated transcription factor and 3) NFkappaB mediates CnAalpha-induced Nox2 and ROS upregulation.	ros	203-206	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	159-167
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	abl interactor 1	Homo sapiens	102-106
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	abl interactor 1	Homo sapiens	102-106
33288900-6	2021	This regulation is mechanistically attributed to DNA hydroxymethylation fostered WDR76 interaction with LSH and increased ratio of DCAF8 to WDR76 for antagonistic LSH association accompanying decreased DNA oxidation along with ROS overproduction.	ros	227-230	helicase, lymphoid specific	Homo sapiens	163-166
33548240-2	2021	Meanwhile, AMPD promotes the formation of substrates of xanthine oxidoreductase (XOR), which produces ROS as a byproduct.	ros	102-105	adenosine monophosphate deaminase 1	Rattus norvegicus	11-15
33934113-5	2021	Knocking down MTHFD1 in HyPer-low cells enhanced cellular ROS and restored sensitivity to gemcitabine.	ros	58-61	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	14-20
33934113-6	2021	Furthermore, the MTHFD1 inhibitor antifolate compound methotrexate (MTX) increased cellular ROS, and combining gemcitabine with MTX effectively suppressed cholangiocarcinoma cell growth.	ros	92-95	methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1	Homo sapiens	17-23
33094643-7	2021	Knockdown of BRD4, or treatment with a BRD4 inhibitor, markedly increased the levels of cell proliferation and invasion and decreased apoptosis and ROS production following the hydrogen peroxide challenge.	ros	148-151	bromodomain containing 4	Homo sapiens	13-17
33094643-7	2021	Knockdown of BRD4, or treatment with a BRD4 inhibitor, markedly increased the levels of cell proliferation and invasion and decreased apoptosis and ROS production following the hydrogen peroxide challenge.	ros	148-151	bromodomain containing 4	Homo sapiens	39-43
33151579-6	2021	Moreover, the presence of OM under hypoxia was shown to influence the extracellular ROS/HIF1A interplay.	ros	84-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-93
33548240-11	2021	CONCLUSIONS: The results suggest that increases in the activity of XOR and the formation of XOR substrates by upregulated AMPD contribute to ROS-mediated diastolic ventricular dysfunction at the time of increased cardiac workload in diabetic hearts.	ros	141-144	adenosine monophosphate deaminase 1	Rattus norvegicus	122-126
33744462-0	2021	Complex I protein NDUFS2 is vital for growth, ROS generation, membrane integrity, apoptosis, and mitochondrial energetics.	ros	46-49	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	18-24
33744462-6	2021	Disruption of NDUFS2 significantly decreased cell growth in medium, Complex I specific respiration, glycolytic capacity, ATP pool and cell-membrane integrity, but significantly increased Complex II respiration, ROS generation, apoptosis, and necrosis.	ros	211-214	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	14-20
33964994-0	2021	CN-3 induces mitochondrial apoptosis in glioma via Ros-mediated PI3K/AKT pathway.	ros	51-54	AKT serine/threonine kinase 1	Homo sapiens	69-72
33791850-0	2021	Correction to: Dexmedetomidine suppresses bupivacaine-induced parthanatos in human SH-SY5Y cells via the miR-7-5p/PARP1 axis-mediated ROS.	ros	134-137	poly(ADP-ribose) polymerase 1	Homo sapiens	114-119
33760192-8	2021	Overall, the present results revealed a novel molecular mechanism whereby TPL induced lethal autophagy through the ROS-JAK2/STAT3 signaling cascade in SKOV3/DDP cells.	ros	115-118	signal transducer and activator of transcription 3	Homo sapiens	124-129
33981228-0	2021	Galangin Inhibits Gastric Cancer Growth Through Enhancing STAT3 Mediated ROS Production.	ros	73-76	signal transducer and activator of transcription 3	Homo sapiens	58-63
33595875-8	2021	Accordingly, gene-specific antisense oligonucleotides assays suggested that suppressing ERF96 decreased ROS levels, whereas suppressing TLP increased the levels of ROS.	ros	164-167	TATA-box binding protein like 1	Homo sapiens	136-139
33904141-10	2021	Anti-IL-23 reduced ROS molecules of STAT downstream in the serum and brain.	ros	19-22	signal transducer and activator of transcription 3	Homo sapiens	36-40
33981228-9	2021	STAT3 overexpression also counteracted excessive ROS accumulation induced by galangin.	ros	49-52	signal transducer and activator of transcription 3	Homo sapiens	0-5
33977107-8	2021	However, ROS inhibition effectively attenuated WIN-induced DNA damage and dysfunction of VEGF-AKT/FAK signal axis and eventually improved U251 cell proliferation, migration, and invasion.	ros	9-12	vascular endothelial growth factor A	Homo sapiens	89-93
33981228-11	2021	Taken together, galangin was suggested to inhibit the growth of MGC 803 cells through inducing apoptosis and decreasing cell proliferation, which might be mediated by modulating STAT3/ROS axis.	ros	184-187	signal transducer and activator of transcription 3	Homo sapiens	178-183
33977107-8	2021	However, ROS inhibition effectively attenuated WIN-induced DNA damage and dysfunction of VEGF-AKT/FAK signal axis and eventually improved U251 cell proliferation, migration, and invasion.	ros	9-12	AKT serine/threonine kinase 1	Homo sapiens	94-97
33924206-9	2021	Via regulation of expression/activity of pro- and anti-apoptotic Bcl-2 family members, and potentially also through the increase in ROS production, CHOP switches on the mitochondrial pathway of apoptosis induction.	ros	132-135	DNA damage inducible transcript 3	Homo sapiens	148-152
33879840-6	2021	TMZ treatment induced intracellular ROS accumulation in U87 and U251 cells via enhancing mitochondrial superoxide, which not only contributed to DNA DSBs and exacerbated mitochondrial dysfunction, but also upregulated FOXO3a expression.	ros	36-39	forkhead box O3	Homo sapiens	218-224
33877317-0	2021	Purpurin, a anthraquinone induces ROS-mediated A549 lung cancer cell apoptosis via inhibition of PI3K/AKT and proliferation.	ros	34-37	AKT serine/threonine kinase 1	Homo sapiens	102-105
33967625-12	2021	In vitro experiments revealed that Xi Lei San could repress apoptosis as well as ROS and inflammatory cytokine production in TNF-alpha-induced CACO2 cells by reducing the activity of NLRP3 inflammasomes and autophagy.	ros	81-84	tumor necrosis factor	Homo sapiens	125-134
33967625-12	2021	In vitro experiments revealed that Xi Lei San could repress apoptosis as well as ROS and inflammatory cytokine production in TNF-alpha-induced CACO2 cells by reducing the activity of NLRP3 inflammasomes and autophagy.	ros	81-84	NLR family pyrin domain containing 3	Homo sapiens	183-188
33880675-6	2022	On the one hand, GRP75 resulted in a change in the redox balance by regulating ROS generation and antioxidant system activity via affecting MMP, NRF2, HO-1, and NQO1 levels.	ros	79-82	heat shock protein family A (Hsp70) member 9	Homo sapiens	17-22
33953705-8	2021	ROS/RNS level was reduced in immune cells after metformin stimulation accompanied by induction of the FOXO3 targets mitochondrial superoxide dismutase and cytochrome c. Studies in Foxo3 deficient (Foxo3-/- ) mouse splenocytes confirmed that metformin mediates its effects via Foxo3 as it attenuates ROS/RNS in myeloid cells of wildtype (WT) but not of Foxo3-/- mice.	ros	299-302	forkhead box O3	Homo sapiens	102-107
33953705-6	2021	The role of the FOXO3 single nucleotide polymorphisms (SNPs) rs12212067, rs2802292 and rs12206094 on ROS/RNS production was studied using allelic discrimination PCR.	ros	101-104	forkhead box O3	Homo sapiens	16-21
33953705-8	2021	ROS/RNS level was reduced in immune cells after metformin stimulation accompanied by induction of the FOXO3 targets mitochondrial superoxide dismutase and cytochrome c. Studies in Foxo3 deficient (Foxo3-/- ) mouse splenocytes confirmed that metformin mediates its effects via Foxo3 as it attenuates ROS/RNS in myeloid cells of wildtype (WT) but not of Foxo3-/- mice.	ros	0-3	forkhead box O3	Homo sapiens	102-107
33866462-7	2021	The IFNg treatment further increased cell death, cell debris amount, apoptosis, and cytokine generations (IL-1beta, IL-6, and TNF-alpha) which were due to increased cytosolic and mitochondrial ROS generations as well as increased activations of caspase-3 and caspase-9.	ros	193-196	interferon gamma	Homo sapiens	4-8
33901898-2	2021	Activating Nrf2, the master switch of the cellular redox system, suppresses ROS, alleviates oxidative stress, and halts cancer progression.	ros	76-79	NFE2 like bZIP transcription factor 2	Homo sapiens	11-15
33936239-7	2021	Our results indicated that SXSM significantly increased the heart rate of SSS mice by reducing the AngII-induced accumulation of ROS in the SAN and by inhibiting the expression of HDAC4, thereby reducing the loss of HCN4, a critical component of the cardiac conduction system.	ros	129-132	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	99-104
34017584-0	2021	Erratum: Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK/ERK signaling pathway.	ros	126-129	mitogen-activated protein kinase 1	Homo sapiens	147-150
33866247-8	2021	The production of ROS in lung tissues of KO mice is significantly higher than that of WT mice after OVA challenge.	ros	18-21	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	100-103
33853670-19	2021	CONCLUSION: These results suggest that the preconditioning with a medium level of LiCl boosts the cell proliferation and differentiation efficacy under a normal or hostile culture condition via the activation of cellular ROS/ERK axis.	ros	221-224	Eph receptor B1	Rattus norvegicus	225-228
33937399-16	2021	Gastrin promotes the production of ROS from mitochondria, activates NF-kappaB, and inhibits apoptosis via modulating the expression level of Bcl-2 and Bax.	ros	35-38	BCL2 apoptosis regulator	Homo sapiens	141-146
33843209-5	2021	MEG3 overexpression noticeably improved diabetes-induced cognitive dysfunctions, accompanied by the abatement of Rac1 activation and ROS production, as well as the inhibition of mitochondria-associated apoptosis.	ros	133-136	similar to GTL2, imprinted maternally expressed untranslated	Rattus norvegicus	0-4
33936239-11	2021	In conclusion, SXSM reduced the AngII-induced accumulation of ROS in the SAN through the PKC/NOX2 signaling pathway, improving the functioning of the SAN and preventing the decrease of heart rate in SSS mice.	ros	62-65	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	32-37
33517195-5	2021	Melanocytes upon exogenous stimulation with TNF-alpha exhibited a significant reduction in cell viability with elevated cellular and mitochondrial ROS and compromised complex I activity.	ros	147-150	tumor necrosis factor	Homo sapiens	44-53
33898327-7	2021	Furthermore, CPT induced the generation of ROS to modulate the AMPK/mTOR/ULK1 axis to finally promote protective autophagy.	ros	43-46	mechanistic target of rapamycin kinase	Homo sapiens	68-72
33898397-0	2021	Oridonin-Loaded Nanoparticles Inhibit Breast Cancer Progression Through Regulation of ROS-Related Nrf2 Signaling Pathway.	ros	86-89	NFE2 like bZIP transcription factor 2	Homo sapiens	98-102
33898397-8	2021	The mechanism experiments showed that the antitumor activity of ORI-NPs against breast cancer might be through ROS related Nrf2/HO-1 signaling pathway.	ros	111-114	NFE2 like bZIP transcription factor 2	Homo sapiens	123-127
33321190-12	2021	In addition, feedback pathway between Akt-dependent Ezh2 phosphorylation and ROS was involved in TSIC-mediated protection of H9c2 cells from apoptosis.	ros	77-80	AKT serine/threonine kinase 1	Rattus norvegicus	38-41
33321190-12	2021	In addition, feedback pathway between Akt-dependent Ezh2 phosphorylation and ROS was involved in TSIC-mediated protection of H9c2 cells from apoptosis.	ros	77-80	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	52-56
32620936-11	2021	Overexpression of GJA1-20k improved mitochondrial membrane potential and respiration and lowered ROS production in Ang II-induced cardiomyocyte hypertrophy.	ros	97-100	gap junction protein, alpha 1	Rattus norvegicus	18-22
32620936-11	2021	Overexpression of GJA1-20k improved mitochondrial membrane potential and respiration and lowered ROS production in Ang II-induced cardiomyocyte hypertrophy.	ros	97-100	angiotensinogen	Rattus norvegicus	115-121
33450497-5	2021	Further mechanistic studies revealed that the alleviation of pulmonary toxicity in 6"-DO-BLM Z by a slight change in the sugar moiety could attribute to the decrease of ROS production and thereby reduce the subsequent caspase-1 activity and resulting inflammatory response.	ros	169-172	caspase 1	Homo sapiens	218-227
33710861-7	2021	Our results show that Olmesartan treatment significantly ameliorates oligomerized Abeta-elevated ROS and MDA levels, as well as the induced senescent cells number.	ros	97-100	amyloid beta precursor protein	Homo sapiens	82-87
33897365-8	2021	In conclusion, the current results suggested that the antihypertensive effect of beta-arrestin1 overexpression in the RVLM is mediated by decreased ROS production, which is associated with Nrf2 activation.	ros	148-151	NFE2 like bZIP transcription factor 2	Rattus norvegicus	189-193
33967591-6	2021	Furthermore, our results show that culturing hMSCs in the microcarrier-based suspension bioreactor (compared to static planar culture) results in smaller cell size and higher levels of reactive oxidative species (ROS) and ROS regulator Sirtuin-3, which have implications on the nicotinamide adenine dinucleotide metabolic pathway and metabolic homeostasis.	ros	222-225	sirtuin 3	Homo sapiens	236-245
32799676-0	2021	The screening of albumin as a key serum component to prevent neutrophil extracellular traps release by selectively inhibiting mitochondrial ROS generation.	ros	140-143	albumin	Homo sapiens	17-24
33577944-8	2021	From the present study, we concluded that CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2, and the increased ROS led to the inactivation of PTEN, Trx-1 and Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	134-137	AKT serine/threonine kinase 1	Homo sapiens	181-184
33577944-16	2021	In conclusion, CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2 to oxidize PTEN and Trx-1 resulting in Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	60-63	AKT serine/threonine kinase 1	Homo sapiens	127-130
33596456-6	2021	Both O2 consumption processes release ROS triggering the antioxidant system activation as we observed increased SOD and catalase activities and a decreased GSH/GSSG ratio.	ros	38-41	catalase	Mus musculus	120-128
33561013-6	2021	Administration of an IRE1alpha inhibitor to lupus-prone MRL/lpr mice over eight weeks reduced mitochondrial ROS levels in peripheral blood neutrophils, while also restraining plasma-cell expansion and autoantibody formation.	ros	108-111	Fas (TNF receptor superfamily member 6)	Mus musculus	60-63
33869226-6	2021	Treatment with Quecetin, Kaempferol, and Vitamin C, targeting CAT, conferred ROS protection and improved contraction; treatment with Hesperidin and Allicin, targeting VCAM1, induced structure enhancement via induction of focal adhesion.	ros	77-80	catalase	Homo sapiens	62-65
33638619-0	2021	Exosomal miR-27 negatively regulates ROS production and promotes granulosa cells apoptosis by targeting SPRY2 in OHSS.	ros	37-40	microRNA 27a	Homo sapiens	9-15
33638619-7	2021	By using MiR-27 mimic, we found it could increase ROS stress and apoptosis by down-regulating the expression of p-ERK/Nrf2 pathway by negatively regulating SPRY2.	ros	50-53	microRNA 27a	Homo sapiens	9-15
33638619-7	2021	By using MiR-27 mimic, we found it could increase ROS stress and apoptosis by down-regulating the expression of p-ERK/Nrf2 pathway by negatively regulating SPRY2.	ros	50-53	mitogen-activated protein kinase 1	Homo sapiens	114-117
33638619-7	2021	By using MiR-27 mimic, we found it could increase ROS stress and apoptosis by down-regulating the expression of p-ERK/Nrf2 pathway by negatively regulating SPRY2.	ros	50-53	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
33638619-7	2021	By using MiR-27 mimic, we found it could increase ROS stress and apoptosis by down-regulating the expression of p-ERK/Nrf2 pathway by negatively regulating SPRY2.	ros	50-53	sprouty RTK signaling antagonist 2	Homo sapiens	156-161
33869226-5	2021	Cross-comparison of transcriptomic profiling data and active compound library identified nine active chemicals targeting ROS neutralizing Catalase (CAT) and structural protein vascular cell adhesion molecule 1 (VCAM1).	ros	121-124	catalase	Homo sapiens	138-146
33869226-5	2021	Cross-comparison of transcriptomic profiling data and active compound library identified nine active chemicals targeting ROS neutralizing Catalase (CAT) and structural protein vascular cell adhesion molecule 1 (VCAM1).	ros	121-124	catalase	Homo sapiens	148-151
33869226-5	2021	Cross-comparison of transcriptomic profiling data and active compound library identified nine active chemicals targeting ROS neutralizing Catalase (CAT) and structural protein vascular cell adhesion molecule 1 (VCAM1).	ros	121-124	vascular cell adhesion molecule 1	Homo sapiens	176-209
33869226-5	2021	Cross-comparison of transcriptomic profiling data and active compound library identified nine active chemicals targeting ROS neutralizing Catalase (CAT) and structural protein vascular cell adhesion molecule 1 (VCAM1).	ros	121-124	vascular cell adhesion molecule 1	Homo sapiens	211-216
33792698-0	2021	The disulfiram/copper complex induces apoptosis and inhibits tumor growth in human osteosarcoma by activating the ROS/JNK signaling pathway.	ros	114-117	mitogen-activated protein kinase 8	Homo sapiens	118-121
33792698-7	2021	The underlying mechanism of this process was explored, and DSF/Cu may mainly inhibit osteosarcoma by inducing apoptosis by activating the ROS/JNK pathway.	ros	138-141	mitogen-activated protein kinase 8	Homo sapiens	142-145
33165828-6	2021	Loss of miR-210 in neurons resulted in higher oxidative phosphorylation and ROS production following hypoxia and increased dendritic arbour density in hippocampal cultures.	ros	76-79	microRNA 210	Mus musculus	8-15
33559814-10	2021	Knockdown of LGR4 increased the apoptosis rate of H9c2 cells and led to excessed oxidant stress and impaired mitochondrial function by increasing the levels of ROS, MDA, LDH, CK and cyt c and inhibiting SOD activity, ATP production.	ros	160-163	leucine-rich repeat-containing G protein-coupled receptor 4	Rattus norvegicus	13-17
33548859-7	2021	The uncoupling of eNOS triggers a switch of its activity from a NO-producing enzyme to a NADPH oxidase-like system generating O2 -, thereby potentiating ROS production and oxidative stress.	ros	153-156	nitric oxide synthase 3	Homo sapiens	18-22
33549731-6	2021	Using function-comparative analysis, we found in the current study that YM155 and BIRC5 siRNA both induced early "autophagy-dependent ROS production-mediated" DNA damage/strand breaks and concurrently downregulated the expression of RAD54L, RAD51, and MRE11, which are molecules known for their important roles in homologous recombination, in human cancer (MCF7, MDA-MB-231, and SK-BR-3) and mouse embryonic fibroblast (MEF) cells.	ros	134-137	MRE11 homolog, double strand break repair nuclease	Homo sapiens	252-257
33486313-8	2021	Mechanistically, suppression of ROS/NFkappaB signaling pathway by increasing fatty acid oxidation-derived NADPH production was involved in the anti-tumorigenic functions of CPT2 in OC cells.	ros	32-35	nuclear factor kappa B subunit 1	Homo sapiens	36-44
33785447-7	2021	In this review, we will summarize the roles of p53 in the regulation of glucose, lipid, amino acid, nucleotide, iron metabolism, and ROS production.	ros	133-136	tumor protein p53	Homo sapiens	47-50
33859780-10	2021	ROS scavenger and the agonist of the PI3K/AKT pathway could reverse these results.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	42-45
33780455-0	2021	CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression.	ros	46-49	AKT serine/threonine kinase 1	Homo sapiens	59-62
33548628-8	2021	Further use of siRNA to interfere with ACSL4 expression in cervical cancer cells revealed that the inhibitory effect of OA on cell viability and proliferative capacity was counteracted, while a decrease in ROS levels and GPX4 was detected, suggesting that OA activated ferroptosis in Hela cells by promoting ACSL4 expression, thereby reducing the survival rate of Hela cells.	ros	206-209	acyl-CoA synthetase long chain family member 4	Homo sapiens	39-44
33833855-5	2021	Decreasing cellular ROS levels using NAC reversed TSM- and TRAIL-induced apoptosis in 143B cells.	ros	20-23	TNF superfamily member 10	Homo sapiens	59-64
33833855-9	2021	These results indicate that cotreatment with TRAIL and TSM evaluated intracellular ROS level, promoted DNA damage, and activated the Bax/PUMA/p53 pathway, leading to activation of both mitochondrial and caspase-mediated apoptosis in 143B cells.	ros	83-86	TNF superfamily member 10	Homo sapiens	45-50
33741719-6	2021	RNA sequencing revealed that mGPDH regulated the RAGE signaling pathway, and inhibition of RAGE or its ligand, S100A10, protected against the impaired mitochondrial bioenergetics and increased ROS generation caused by mGPDH knockdown in cultured podocytes.	ros	193-196	advanced glycosylation end product-specific receptor	Mus musculus	91-95
33743823-8	2021	Through ELISA analysis, testosterone levels and MDA, SOD, LDH, and CAT activities, which are associated with ROS, were detected.	ros	109-112	catalase	Mus musculus	67-70
33823482-1	2021	The reaction between Co(II) and PMS is an appealing advanced oxidation process (AOP), where multiple reactive oxidizing species (ROS) including high-valent cobalt-oxo [Co(IV)], sulfate radical (SO4 -), and hydroxy radical ( OH) are intertwined together for degrading pollutants.	ros	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-27
33868142-11	2021	Mechanistically, the WF reduced the liver damage caused by chronic stress in rats by inhibiting the NOX4/ROS/NF-kappaB signaling pathway.	ros	105-108	nuclear factor kappa B subunit 1	Homo sapiens	109-118
33823482-4	2021	Using chemical scavenging methods, the role of SO4 - and  OH was also identified, and the major ROS were converted from Co(IV) to radical species with the increase of PMS/Co(II) molar ratio as well as pH value.	ros	96-99	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	171-177
33723743-0	2022	Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts.	ros	59-62	aryl-hydrocarbon receptor	Mus musculus	34-37
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	ros	154-157	NLR family pyrin domain containing 3	Homo sapiens	104-109
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	ros	154-157	toll like receptor 2	Homo sapiens	136-140
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	ros	154-157	nuclear factor kappa B subunit 1	Homo sapiens	161-170
33723743-6	2022	Our findings provide evidence for the functional role of Jdp2 in controlling the AhR gene via Nrf2 and provide insights into how Jdp2 contributes to the regulation of ROS production and the cell spreading and apoptosis produced by the ligand DMSO in MEFs.	ros	167-170	aryl-hydrocarbon receptor	Mus musculus	81-84
33723743-6	2022	Our findings provide evidence for the functional role of Jdp2 in controlling the AhR gene via Nrf2 and provide insights into how Jdp2 contributes to the regulation of ROS production and the cell spreading and apoptosis produced by the ligand DMSO in MEFs.	ros	167-170	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98
33720048-6	2021	Mechanistically, caspase-1 activation closely correlated with the inflammatory marker expression and was shown to occur through NLRP3 inflammasome activation driven by virus-dependent and/or -independent ROS production, while caspase-3 activation in CD4+ T cells was more closely related to T cell activation status.	ros	204-207	caspase 1	Homo sapiens	17-26
33660298-7	2022	Meanwhile, the gene expression levels of ROS scavengers (i.e., AtCAT3, AtFeSOD1 and AtCu-ZnSOD3) were up-regulated in the AtOE plants, and the transcription levels of ROS producing enzyme genes were significantly down-regulated.	ros	41-44	catalase 3	Arabidopsis thaliana	63-69
33676890-0	2021	Citrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation.	ros	87-90	TNF superfamily member 10	Homo sapiens	65-70
33676890-5	2021	Furthermore, cytotoxicity, apoptotic activity, and activation of caspase cascades were determined in HCT116 and HT-29 cell-based systems, the results indicated that DHCP enhances the sensitivity of cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), with DHCP-induced ROS accounting for the synergistic effect between DHCP and TRAIL.	ros	297-300	TNF superfamily member 10	Homo sapiens	214-269
33676890-7	2021	ROS significantly increase the expression of TRAIL death receptor 5 (DR5) via the p53 and C/EBP homologous protein pathways.	ros	0-3	tumor protein p53	Homo sapiens	82-85
33754072-6	2021	Results: We found that the upregulation of S100A9 induces cell injury and inflammatory response via NLRP3 activation by targeting VNN1-mediated ROS release; and loss of S100A9 decreases AP injury in vitro and in vivo.	ros	144-147	NLR family, pyrin domain containing 3	Rattus norvegicus	100-105
33720048-6	2021	Mechanistically, caspase-1 activation closely correlated with the inflammatory marker expression and was shown to occur through NLRP3 inflammasome activation driven by virus-dependent and/or -independent ROS production, while caspase-3 activation in CD4+ T cells was more closely related to T cell activation status.	ros	204-207	NLR family pyrin domain containing 3	Homo sapiens	128-133
33660298-7	2022	Meanwhile, the gene expression levels of ROS scavengers (i.e., AtCAT3, AtFeSOD1 and AtCu-ZnSOD3) were up-regulated in the AtOE plants, and the transcription levels of ROS producing enzyme genes were significantly down-regulated.	ros	167-170	catalase 3	Arabidopsis thaliana	63-69
33754307-1	2021	The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles in the defense system against electrophilic or oxidative stress by upregulating an array of genes encoding antioxidant proteins, electrophile/reactive oxygen species (ROS) detoxifying enzymes, and drug efflux transporters.	ros	261-264	NFE2 like bZIP transcription factor 2	Homo sapiens	25-58
33654072-4	2021	Mice with reduced expression of XBP1 (heterozygous Xbp1+-) were resistant to IR-induced AKI due to the enhanced expression of NRF2/HO-1 and diminished ROS in the kidney.	ros	151-154	X-box binding protein 1	Mus musculus	32-36
33654072-4	2021	Mice with reduced expression of XBP1 (heterozygous Xbp1+-) were resistant to IR-induced AKI due to the enhanced expression of NRF2/HO-1 and diminished ROS in the kidney.	ros	151-154	X-box binding protein 1	Mus musculus	51-55
33754307-5	2021	A particular focus was put on the role of NRF2 in CSCs maintenance and therapy resistance, showing that low ROS levels and refractory drug response of CSCs are mediated by the activation of NRF2 signaling.	ros	108-111	NFE2 like bZIP transcription factor 2	Homo sapiens	190-194
33654066-10	2021	Overexpression of Arg-II in the cells enhances TGFbeta1 levels which is prevented by mitochondrial ROS inhibition.	ros	99-102	transforming growth factor beta 1	Homo sapiens	47-55
33754307-1	2021	The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles in the defense system against electrophilic or oxidative stress by upregulating an array of genes encoding antioxidant proteins, electrophile/reactive oxygen species (ROS) detoxifying enzymes, and drug efflux transporters.	ros	261-264	NFE2 like bZIP transcription factor 2	Homo sapiens	60-66
33754307-1	2021	The transcription factor nuclear factor erythroid 2-like 2 (NEF2L2; NRF2) plays crucial roles in the defense system against electrophilic or oxidative stress by upregulating an array of genes encoding antioxidant proteins, electrophile/reactive oxygen species (ROS) detoxifying enzymes, and drug efflux transporters.	ros	261-264	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
33754307-5	2021	A particular focus was put on the role of NRF2 in CSCs maintenance and therapy resistance, showing that low ROS levels and refractory drug response of CSCs are mediated by the activation of NRF2 signaling.	ros	108-111	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
33838628-8	2021	The MDR1 gene was overexpressed to develop resistant HCT-116/R cells and the NOX activation and ROS generation were monitored.	ros	96-99	ATP binding cassette subfamily B member 1	Homo sapiens	4-8
33570794-0	2021	PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling.	ros	104-107	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
33347603-0	2021	Quercetin Induces p53-independent Cancer Cell Death via TFEB-mediated Lysosome Activation and ROS-dependent Ferroptosis.	ros	94-97	tumor protein p53	Homo sapiens	18-21
33421718-13	2021	In addition, BaP increased mitochondrial ROS production, and Mito-TEMP, a mitochondrial ROS inhibitor, inhibited BaP-induced MUC5AC expression and ERK activation.	ros	88-91	muc5ac	None	125-131
33388592-0	2021	SO2 derivatives induce dysfunction in human trophoblasts via inhibiting ROS/IL-6/STAT3 pathway.	ros	72-75	interleukin 6	Homo sapiens	76-80
33388592-0	2021	SO2 derivatives induce dysfunction in human trophoblasts via inhibiting ROS/IL-6/STAT3 pathway.	ros	72-75	signal transducer and activator of transcription 3	Homo sapiens	81-86
33388592-15	2021	Decreased ROS/IL-6/STAT3 levels play a role in inhibited cell viability, cell cycle arrest, apoptosis and defective motility.	ros	10-13	interleukin 6	Homo sapiens	14-18
33388592-15	2021	Decreased ROS/IL-6/STAT3 levels play a role in inhibited cell viability, cell cycle arrest, apoptosis and defective motility.	ros	10-13	signal transducer and activator of transcription 3	Homo sapiens	19-24
33421718-0	2021	Benzo(a)pyrene induces MUC5AC expression through the AhR/mitochondrial ROS/ERK pathway in airway epithelial cells.	ros	71-74	muc5ac	None	23-29
33421718-0	2021	Benzo(a)pyrene induces MUC5AC expression through the AhR/mitochondrial ROS/ERK pathway in airway epithelial cells.	ros	71-74	ahr	None	53-56
32898935-6	2021	HIF-1alpha stabilization was detected in 4-NB treated cells, possibly due to the contribution of both reduction of intracellular oxygen tension and ROS overproduction.	ros	148-151	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
33570794-0	2021	PARP-1 involves in UVB-induced inflammatory response in keratinocytes and skin injury via regulation of ROS-dependent EGFR transactivation and p38 signaling.	ros	104-107	epidermal growth factor receptor	Homo sapiens	118-122
33460768-7	2021	NPGPx is activated by ROS generated from TCR stimulation, and modulates ZAP70 activity through redox switching to reduce ZAP70 recruitment to TCR/CD3 complex in membrane lipid raft, therefore subduing TCR responses.	ros	22-25	CD247 antigen	Mus musculus	146-149
33570794-11	2021	Of note, genetic ablation of PARP-1 or EGFR can attenuate UVB-induced ROS production, and antioxidant NAC can attenuate UVB-induced EGFR-p38 signaling axis and PARP-1 activation.	ros	70-73	poly(ADP-ribose) polymerase 1	Homo sapiens	29-35
33570794-13	2021	PARP-1 not only serves DNA repair function but also orchestrates interactions to EGFR transactivation and ROS production, leading to p38 signaling for inflammatory gene expression in keratinocytes.	ros	106-109	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
33502586-9	2021	CONCLUSION: VIP/FPRL1/VPAC/GTP-RhoA-GTPase signaling modulated macrophages phenotype through activation of multiple signaling pathways including ERK1/2, AKT, P38, ROS, cAMP and calcium.	ros	163-166	vasoactive intestinal peptide	Homo sapiens	12-15
33450344-6	2021	BP1 effectively reduced PA-induced lipotoxicity by eliminating accumulation of ROS, improving mitochondrial function, reversing glutathione depletion and enhancing antioxidant enzyme activities.	ros	79-82	BP1	Homo sapiens	0-3
33283586-4	2021	Moreover, the micelles could down-regulate ATP levels and promote ROS production in MCF-7/ADR via the mitochondrial impairment, therefore achieving MDR reversal and cell apoptosis.	ros	66-69	aldo-keto reductase family 1 member B	Homo sapiens	90-93
33242123-0	2021	Retraction Note to: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway.	ros	104-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	108-114
33307093-9	2021	In addition, knockout of ZIP13 induced increases of mitochondrial Ca2+, ROS, mitochondrial swelling, decrease in the mitochondrial respiration control rate (RCR), and dissipation of mitochondrial membrane potential (DeltaPsim) in a CaMKII-dependent manner.	ros	72-75	solute carrier family 39 (metal ion transporter), member 13	Mus musculus	25-30
33242123-0	2021	Retraction Note to: Chrysophanol exhibits anti-cancer activities in lung cancer cell through regulating ROS/HIF-1a/VEGF signaling pathway.	ros	104-107	vascular endothelial growth factor A	Homo sapiens	115-119
33383234-0	2021	Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway.	ros	107-110	NLR family pyrin domain containing 3	Homo sapiens	111-116
33568303-5	2021	Numerous dehydration induced ROS-scavenging genes were upregulated in SlGRAS4-OE plants after drought stress, implying that SlGRAS4 confers drought tolerance by modulating ROS homeostasis.	ros	29-32	GRAS4	Solanum lycopersicum	70-77
33568303-5	2021	Numerous dehydration induced ROS-scavenging genes were upregulated in SlGRAS4-OE plants after drought stress, implying that SlGRAS4 confers drought tolerance by modulating ROS homeostasis.	ros	172-175	GRAS4	Solanum lycopersicum	70-77
33531626-5	2021	Functionally, USP11 depletion contributes to the suppression of cell proliferation and induction of ferroptotic cell death due to ROS-mediated stress, which can be largely abrogated by overexpression of NRF2.	ros	130-133	NFE2 like bZIP transcription factor 2	Homo sapiens	203-207
33383234-0	2021	Reduced intracellular antioxidant capacity in platelets contributes to primary immune thrombocytopenia via ROS-NLRP3-caspase-1 pathway.	ros	107-110	caspase 1	Homo sapiens	117-126
33527955-0	2021	The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells.	ros	87-90	AKT serine/threonine kinase 1	Homo sapiens	101-104
33527955-0	2021	The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells.	ros	87-90	caspase 3	Homo sapiens	105-114
33543924-0	2021	Targeting ROS-Dependent AKT/GSK-3beta/NF-kappaB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson"s Disease Rat Model.	ros	10-13	AKT serine/threonine kinase 1	Rattus norvegicus	24-27
33681190-11	2021	The in vitro results showed that TGF-beta1 significantly inhibited mitochondrial ATP production rate and increased mitochondrial ROS (mtROS) production when compared to control, which was normalized by KCa3.1 gene silencing.	ros	129-132	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4	Mus musculus	202-208
33600604-10	2021	Livers of visfatin-injected mice showed upregulation of ER stress and ROS and activation of JNK signalling.	ros	70-73	nicotinamide phosphoribosyltransferase	Mus musculus	10-18
33642877-8	2021	PTPN18 knockdown increased intracellular ROS level and down-regulated GPX4 and xCT expression.	ros	41-44	protein tyrosine phosphatase non-receptor type 18	Homo sapiens	0-6
33543924-0	2021	Targeting ROS-Dependent AKT/GSK-3beta/NF-kappaB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson"s Disease Rat Model.	ros	10-13	Parkinsonism associated deglycase	Rattus norvegicus	52-56
33543924-0	2021	Targeting ROS-Dependent AKT/GSK-3beta/NF-kappaB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson"s Disease Rat Model.	ros	10-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	57-61
33565347-5	2021	Up-regulated Ribulose-5-Phosphate and NADPH/NADP+ level, SOD1, and CAT expression by ouabain enabled OCI-Ly3 cells to resist ROS, while enhanced hypoxanthine and guanine oxidation promoting ROS generation by ouabain, and lowered capacity of scavenging ROS indicated by lowered SOD1 and CAT expression and NADPH/NADP+ levels in Su-DHL4 cells made it more vulnerable to apoptosis through caspase 7 pathway.	ros	190-193	catalase	Homo sapiens	67-70
33664650-2	2021	The present study investigated whether exercise postconditioning (PostE) induced neuroprotection and elucidated the involvement of SIRT1 regulation on the ROS/ER stress pathway.	ros	155-158	sirtuin 1	Rattus norvegicus	131-136
33189440-4	2021	Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays.	ros	30-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	208-228
33189440-4	2021	Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays.	ros	30-33	acetylcholinesterase (Cartwright blood group)	Homo sapiens	230-234
33189440-4	2021	Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays.	ros	195-198	acetylcholinesterase (Cartwright blood group)	Homo sapiens	208-228
33189440-4	2021	Herein, we report a series of ROS-responsive prodrugs based on multi-target-directed ligands (MTDLs) approach, which can specifically release tacrine derivatives and ibuprofen under oxidation of ROS and show acetylcholinesterase (AChE)-inhibiting, neuron-protective and anti-inflammatory effects in extracellular or intracellular assays.	ros	195-198	acetylcholinesterase (Cartwright blood group)	Homo sapiens	230-234
33628364-10	2021	Conclusion: Our results demonstrated that the inhibition of Dot1l alleviated corneal oxidative stress and inflammation by inhibiting ROS production through the p38 MAPK pathway in HSK.	ros	133-136	DOT1 like histone lysine methyltransferase	Homo sapiens	60-65
33565347-5	2021	Up-regulated Ribulose-5-Phosphate and NADPH/NADP+ level, SOD1, and CAT expression by ouabain enabled OCI-Ly3 cells to resist ROS, while enhanced hypoxanthine and guanine oxidation promoting ROS generation by ouabain, and lowered capacity of scavenging ROS indicated by lowered SOD1 and CAT expression and NADPH/NADP+ levels in Su-DHL4 cells made it more vulnerable to apoptosis through caspase 7 pathway.	ros	125-128	catalase	Homo sapiens	67-70
33452125-4	2021	HRG and C5a prolonged the survival time of isolated human neutrophils, in association with a reduction in the spontaneous production of extracellular ROS.	ros	150-153	complement C5a receptor 1	Homo sapiens	8-11
33754045-15	2021	The KEAP1-NRF2 and mTORC1-cMyc axis are independently activated upon ADSL overexpression and may favor the survival and proliferation of ROS-accumulating cells, favoring DNA damage and tumorigenesis.	ros	137-140	kelch like ECH associated protein 1	Homo sapiens	4-9
33754045-15	2021	The KEAP1-NRF2 and mTORC1-cMyc axis are independently activated upon ADSL overexpression and may favor the survival and proliferation of ROS-accumulating cells, favoring DNA damage and tumorigenesis.	ros	137-140	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
33565347-5	2021	Up-regulated Ribulose-5-Phosphate and NADPH/NADP+ level, SOD1, and CAT expression by ouabain enabled OCI-Ly3 cells to resist ROS, while enhanced hypoxanthine and guanine oxidation promoting ROS generation by ouabain, and lowered capacity of scavenging ROS indicated by lowered SOD1 and CAT expression and NADPH/NADP+ levels in Su-DHL4 cells made it more vulnerable to apoptosis through caspase 7 pathway.	ros	190-193	catalase	Homo sapiens	67-70
33353358-9	2021	Moreover, we identified the target effect of point composition in the ROS/Akt signaling pathway.	ros	70-73	AKT serine/threonine kinase 1	Rattus norvegicus	74-77
32979141-5	2021	Quantitative real-time PCR and western blot analysis demonstrated that drug combination-induced mitochondrial apoptosis was activated through the ROS-mediated PERK/eIF2alpha/ATF4/CHOP pathway.	ros	146-149	DNA damage inducible transcript 3	Homo sapiens	179-183
33537886-7	2021	Interestingly, pretreatment with G-Rg2 and -Rh1 effectively inhibited mitochondrial damage-mediated ROS production induced by LPS stimulation, and alterations of Nrf2 nuclear translocation and ARE promotor activity were involved in G-Rg2 and -Rh1 effects on balancing ROS levels.	ros	268-271	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
33310051-3	2021	Among the reported 8 GPxs, GPx3, a highly conserved protein and a major ROS scavenger in plasma, has been well studied and confirmed to play a vital role as a tumor suppressor in most cancers.	ros	72-75	glutathione peroxidase 3	Homo sapiens	27-31
33253803-0	2021	Soybean lectin induces autophagy through P2RX7 dependent activation of NF-kappaB-ROS pathway to kill intracellular mycobacteria.	ros	81-84	LOW QUALITY PROTEIN: lectin	Glycine max	8-14
33212230-0	2021	Use of 2-dimensional cell monolayers and 3-dimensional microvascular networks on microfluidic devices shows that iron increases transendothelial adiponectin flux via inducing ROS production.	ros	175-178	adiponectin, C1Q and collagen domain containing	Homo sapiens	145-156
33189448-7	2021	After blocking the corresponding pathway, it was found that ROS mediates ASK1 and JNK activation.	ros	60-63	mitogen-activated protein kinase 8	Homo sapiens	82-85
33445099-5	2021	The PDA-ICG@CAT-DTA-1 exhibits intrinsic local hyperthermia and enhanced ROS generation in tumor, and abrogates tumor immune suppression.	ros	73-76	catalase	Mus musculus	12-15
33360932-9	2021	Here we showed that genetic deletion of HDAC5 and pharmacological inhibition of class IIa HDACs ameliorated Ang II-induced ROS generation.	ros	123-126	histone deacetylase 5	Mus musculus	40-45
33360932-9	2021	Here we showed that genetic deletion of HDAC5 and pharmacological inhibition of class IIa HDACs ameliorated Ang II-induced ROS generation.	ros	123-126	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	108-114
32094504-6	2021	Mechanistic experiments demonstrated that TRIM34 controlled TLR signaling-induced Nox/Duox-dependent ROS synthesis, thereby promoting the compound exocytosis of Muc2 by colonic GCs that were exposed to bacterial TLR ligands.	ros	101-104	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	161-165
33217539-0	2021	Eldecalcitol induces apoptosis and autophagy in human osteosarcoma MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway.	ros	95-98	AKT serine/threonine kinase 1	Homo sapiens	120-123
33217539-0	2021	Eldecalcitol induces apoptosis and autophagy in human osteosarcoma MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway.	ros	95-98	mechanistic target of rapamycin kinase	Homo sapiens	124-128
33217539-11	2021	In conclusion, our results reveal that ED-71 induced G2/M arrest, apoptosis and autophagy in MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway.	ros	121-124	AKT serine/threonine kinase 1	Homo sapiens	146-149
33217539-11	2021	In conclusion, our results reveal that ED-71 induced G2/M arrest, apoptosis and autophagy in MG-63 cells by accumulating ROS to suppress the PI3K/Akt/mTOR signaling pathway.	ros	121-124	mechanistic target of rapamycin kinase	Homo sapiens	150-154
33326693-6	2021	This beneficial effect of PLCgamma1 inhibition was counteracted by increased chondrocyte apoptosis and necroptosis, increased cell death, and increase levels of ROS, all potentially negative for OA.	ros	161-164	phospholipase C, gamma 1	Rattus norvegicus	26-35
33359686-10	2021	We conclude that AntiOxBEN2 and AntiOxCIN4 increase ROS levels, which stimulates NRF2 expression and, as a consequence, SOD2 and GSH levels.	ros	52-55	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
33326693-7	2021	Combined treatment of IL-1beta+U73122-treated chondrocytes with inhibitors of apoptosis (Z-VAD, 10 muM) and necroptosis (Nec-1, 30 muM) enhanced the increases in levels and expression of Collagen2 and Aggrecan, and prevented the increases in cell death and ROS levels.	ros	257-260	interleukin 1 alpha	Rattus norvegicus	22-30
33579452-5	2021	The generation of ROS was enhanced using TRF:CA:CIS by 16.9% and 30.2% for A549 and HEP G2, respectively.	ros	18-21	telomeric repeat binding factor 1	Homo sapiens	41-44
33597889-8	2021	Furthermore, mechanistic investigations demonstrated that crizotinib and sunitinib accumulated ROS and inhibited Nrf2 signaling, and that ROS scavenger NAC and Nrf2 agonist tBHQ alleviated the extent of cell damage and the mitochondrial apoptosis during crizotinib- and sunitinib-induced hepatotoxicity in L02 cells.	ros	138-141	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33474594-12	2021	Furthermore, we found that knocking out of TLR4 led to inhibited cytoplasmic and mitochondrial ROS production, which in turn, attenuated ICAM-1 expression at both the protein and cell surface levels.	ros	95-98	toll-like receptor 4	Mus musculus	43-47
33474594-13	2021	CONCLUSION: This study demonstrates that the mechanism of ICAM-1-mediated macrophage phagocytosis is depending on TLR4-mediated ROS production and provides significant light on macrophage ICAM-1 in endotoxemia.	ros	128-131	toll-like receptor 4	Mus musculus	114-118
32605461-5	2021	Overexpression of NLRC5 caused significant increase in cell viability, as well as decrease in ROS level.	ros	94-97	NLR family CARD domain containing 5	Homo sapiens	18-23
32920707-7	2021	By virtue of the complicated research progress on FSP1 with ferroptosis, in this review, we summarize the whole region of relevance between ROS and RA.	ros	140-143	atlastin GTPase 1	Homo sapiens	50-54
32920707-8	2021	Taken together, we hypothesize that ROS accompanied with ferroptosis may function as a reciprocal with cell death that interplays with RA; besides, FSP1 might become a potential therapeutic target for RA because of its potential interaction with TNF-alpha/ROS-positive feedback loop.	ros	36-39	atlastin GTPase 1	Homo sapiens	148-152
32920707-8	2021	Taken together, we hypothesize that ROS accompanied with ferroptosis may function as a reciprocal with cell death that interplays with RA; besides, FSP1 might become a potential therapeutic target for RA because of its potential interaction with TNF-alpha/ROS-positive feedback loop.	ros	36-39	tumor necrosis factor	Homo sapiens	246-255
32920707-8	2021	Taken together, we hypothesize that ROS accompanied with ferroptosis may function as a reciprocal with cell death that interplays with RA; besides, FSP1 might become a potential therapeutic target for RA because of its potential interaction with TNF-alpha/ROS-positive feedback loop.	ros	256-259	atlastin GTPase 1	Homo sapiens	148-152
32920707-8	2021	Taken together, we hypothesize that ROS accompanied with ferroptosis may function as a reciprocal with cell death that interplays with RA; besides, FSP1 might become a potential therapeutic target for RA because of its potential interaction with TNF-alpha/ROS-positive feedback loop.	ros	256-259	tumor necrosis factor	Homo sapiens	246-255
33201401-5	2021	Further experiments showed that curcumin not only decreased the production of ROS and MDA but also increased the activities of the ROS scavenging enzymes SOD and CAT.	ros	131-134	superoxide dismutase 1	Homo sapiens	154-157
33201401-5	2021	Further experiments showed that curcumin not only decreased the production of ROS and MDA but also increased the activities of the ROS scavenging enzymes SOD and CAT.	ros	131-134	catalase	Homo sapiens	162-165
33095436-10	2021	Thymol induced ROS by reducing the SOD level which was confirmed via in vitro and in silico analysis.	ros	15-18	superoxide dismutase 1	Homo sapiens	35-38
33054537-9	2021	The time dependent induction of DNA breaks demonstrated in PC3 cells treated with MPO safe concentration stimulated ROS generation and apoptotic DNA damage through increased expression of tumor suppressor p53 and Bax genes and decreased expression of Bcl2 and MDM2 genes.	ros	116-119	tumor protein p53	Homo sapiens	205-208
33486268-13	2021	CONCLUSION: Our results suggest that Daph triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway.	ros	51-54	AKT serine/threonine kinase 1	Homo sapiens	138-141
33486268-13	2021	CONCLUSION: Our results suggest that Daph triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway.	ros	51-54	mechanistic target of rapamycin kinase	Homo sapiens	142-146
33054537-9	2021	The time dependent induction of DNA breaks demonstrated in PC3 cells treated with MPO safe concentration stimulated ROS generation and apoptotic DNA damage through increased expression of tumor suppressor p53 and Bax genes and decreased expression of Bcl2 and MDM2 genes.	ros	116-119	BCL2 associated X, apoptosis regulator	Homo sapiens	213-216
33301752-0	2021	Soybean lectin induces autophagy through P2RX7 dependent activation of NF-kappaB-ROS pathway to kill intracellular mycobacteria.	ros	81-84	LOW QUALITY PROTEIN: lectin	Glycine max	8-14
33148527-10	2021	On the whole, our present study suggested that 1] ROS could modify H3K9 methylation via G9a and promote radiation-induced lung EMT in Beas2B and A549 cells 2] E-cadherin promoter enrichment with heterochromatin mark H3K9me2 expression upon irradiation could be modified by regulating G9a methyltransferase.	ros	50-53	cadherin 1	Homo sapiens	159-169
33148527-0	2021	Radiation-induced H3K9 methylation on E-cadherin promoter mediated by ROS/Snail axis : Role of G9a signaling during lung epithelial-mesenchymal transition.	ros	70-73	cadherin 1	Homo sapiens	38-48
33188878-11	2021	Calycosin resisted HCC by activating ROS-mediated MAPK, STAT3, and NF-kappaB signaling pathways.	ros	37-40	signal transducer and activator of transcription 3	Homo sapiens	56-61
33345265-0	2021	A paradox: Fe2+-containing agents decreased ROS and apoptosis induced by CoNPs in vascular endothelial cells by inhibiting HIF-1alpha.	ros	44-47	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
33509753-13	2021	CONCLUSIONS: Hepatocytes-specific NDUFA13 ablation can trigger spontaneous hepatitis in mice possibly mediated by the activation of ROS/NF-kappaB/NLRP3 signaling.	ros	132-135	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
33427275-5	2021	Furthermore, TTRh-CN can efficiently produce ROS in conjunction with lysosomes in situ upon light irradiation, which can damage lysosomes, up-regulate LC3 and Beclin1, increase BAX release, and induce cell apoptosis.	ros	45-48	BCL2 associated X, apoptosis regulator	Homo sapiens	177-180
33585431-0	2021	ROS-Sensitive Nanoparticles Co-delivering Dexamethasone and CDMP-1 for the Treatment of Osteoarthritis Through Chondrogenic Differentiation Induction and Inflammation Inhibition.	ros	0-3	growth differentiation factor 5	Homo sapiens	60-66
33501881-12	2021	In addition, overexpression of CTRP3 attenuated the OGD/R-caused oxidative stress with decreased ROS production and increased activities of SOD and GPx.	ros	97-100	C1q and TNF related 3	Homo sapiens	31-36
33503015-0	2021	Correction for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury.	ros	35-38	AKT serine/threonine kinase 1	Homo sapiens	74-77
33503015-0	2021	Correction for: Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury.	ros	35-38	mechanistic target of rapamycin kinase	Homo sapiens	78-82
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	ros	171-174	apelin	Homo sapiens	17-23
33501731-0	2021	Photobiomodulation Therapy for Thrombocytopenia by Upregulating Thrombopoietin Expression via the ROS-dependent Src/ERK/STAT3 Signaling Pathway.	ros	98-101	mitogen-activated protein kinase 1	Mus musculus	116-119
33501731-0	2021	Photobiomodulation Therapy for Thrombocytopenia by Upregulating Thrombopoietin Expression via the ROS-dependent Src/ERK/STAT3 Signaling Pathway.	ros	98-101	signal transducer and activator of transcription 3	Mus musculus	120-125
33468664-5	2021	Using multiple mouse models of ROS-induced cancer, we show that Mdm2 phosphorylation by Akt reduces senescence to promote KrasG12D-driven lung cancers and carcinogen-induced papilloma and hepatocellular carcinomas.	ros	31-34	thymoma viral proto-oncogene 1	Mus musculus	88-91
33499140-0	2021	Protective Role of Natural and Semi-Synthetic Tocopherols on TNFalpha-Induced ROS Production and ICAM-1 and Cl-2 Expression in HT29 Intestinal Epithelial Cells.	ros	78-81	tumor necrosis factor	Homo sapiens	61-69
33388412-6	2021	Chromatin immunoprecipitation experiment revealed that HIF-1alpha overexpression in hypoxic cardiomyocytes increases binding of HIF-1alpha to the hypoxia-responsive element in the promoter of its target anti-oxidant gene ho-1 which is known to attenuate ROS accumulation.	ros	254-257	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
33388412-6	2021	Chromatin immunoprecipitation experiment revealed that HIF-1alpha overexpression in hypoxic cardiomyocytes increases binding of HIF-1alpha to the hypoxia-responsive element in the promoter of its target anti-oxidant gene ho-1 which is known to attenuate ROS accumulation.	ros	254-257	hypoxia inducible factor 1 subunit alpha	Homo sapiens	128-138
33388412-7	2021	ROS accumulation in hypoxic cardiomyocytes causes cysteine oxidation of the DNA-binding p50 subunit of NFkappaB, which hampers NFkappaB binding to kappaB-responsive genes like bnip3.	ros	0-3	nuclear factor kappa B subunit 1	Homo sapiens	103-111
33388412-7	2021	ROS accumulation in hypoxic cardiomyocytes causes cysteine oxidation of the DNA-binding p50 subunit of NFkappaB, which hampers NFkappaB binding to kappaB-responsive genes like bnip3.	ros	0-3	BCL2 interacting protein 3	Homo sapiens	176-181
33058356-2	2021	Conversely, the ability of N-truncated isoforms of Abeta to alter the Cu-induced ROS production has been overlooked even though they are main constituents of amyloid plaques found in the human brain.	ros	81-84	amyloid beta precursor protein	Homo sapiens	51-56
33271149-7	2021	Nrf2 inhibition by Kaempferol induces ROS accumulation after 48 h of treatment and makes NSCLC cells sensitive to apoptosis at physiological concentration.	ros	38-41	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
33058356-7	2021	Here, we report in-depth spectroscopic characterizations (Cu(II) and Cu(I)) complexes of the Abeta 4-16 and Abeta 11-16 N-truncated peptides and ROS production studies with copper (Cu(II) and Cu(I)) complexes of the Abeta 4-16 and Abeta 11-16 N-truncated peptides.	ros	145-148	amyloid beta precursor protein	Homo sapiens	108-113
33510836-10	2021	Using gain-of-function and loss-of-function approaches, we observe dramatic exacerbation of insulin resistance, upregulated gluconeogenesis genes, downregulated glucose transport genes, and enhanced ROS production by FAF1 overexpression, whereas downregulation of FAF1 leads to a completely opposite phenotype.	ros	199-202	Fas associated factor 1	Rattus norvegicus	217-221
33039867-0	2021	ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.	ros	0-3	tumor protein p53	Homo sapiens	150-153
33039867-13	2021	These results suggest that ROS-mediated genotoxic stress is involved in NaAsO2-induced cell cycle arrest, stemness enhancement and chemoresistance of prostate cancer cells in a p53-independent manner.	ros	27-30	tumor protein p53	Homo sapiens	177-180
33519423-0	2020	Atorvastatin Attenuates Isoflurane-Induced Activation of ROS-p38MAPK/ATF2 Pathway, Neuronal Degeneration, and Cognitive Impairment of the Aged Mice.	ros	57-60	activating transcription factor 2	Mus musculus	69-73
33242463-5	2021	Mechanistically, tumor HIF1alpha signaling activated by chemo-induced ROS drives the transcription of HMGB1 to promote more macrophage infiltration into CRC tumor.	ros	70-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-32
33396077-8	2021	ROS induced alteration in p53 regulation and some mitogen/ oncogenic functions determine the transformation outcome influencing cyclin-cdk complexes.	ros	0-3	tumor protein p53	Homo sapiens	26-29
33278392-8	2021	Significantly up-regulated GPX1, SOD2 and GSH contributed to the down-regulated ROS content in SIN-treated groups.	ros	80-83	glutathione peroxidase 1	Rattus norvegicus	27-31
33446631-0	2021	ARNT deficiency represses pyruvate dehydrogenase kinase 1 to trigger ROS production and melanoma metastasis.	ros	69-72	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	26-57
33446631-4	2021	The depletion of ARNT dramatically repressed PDK1 and NQO1 expression, which resulted in an increase of ROS levels.	ros	104-107	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	45-49
33372513-8	2021	Collectively, these results revealed that TAN and 5-HPMF prevented the pathological process of BIIC-stimulated arthritis through inhibiting the autophagy of synovial cells, achieved via the ROS-AKT/mTOR signal axis.	ros	190-193	AKT serine/threonine kinase 1	Rattus norvegicus	194-197
33441543-5	2021	We could further show that NRF2 is paramount for proliferation, ROS elimination, and radioprotection under constant hypoxia (1% O2), but is dispensable under normoxic conditions or after reoxygenation.	ros	64-67	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
33414469-7	2021	Mechanistically, the inhibition of MSH2 by Nrf2 was in a ROS-independent manner.	ros	57-60	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
33483237-11	2021	A direct linear relationship was observed between higher ROS and increasing units of PBT (beta = 0.586, P = 0.038).	ros	57-60	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	85-88
33346645-4	2021	We find that Fe3O4 nanozymes exhibit triple enzyme-like activities, peroxidase, catalase, and superoxide dismutase, thus potentially possessing the ability to regulate the ROS level.	ros	172-175	catalase	Homo sapiens	80-88
33413468-10	2021	In addition, both PSEN1 and PSEN2-BMECs displayed reduced bioenergetics, lysosomal acidification, autophagy, while showing an increase in radical oxygen species (ROS) production.	ros	162-165	presenilin 2	Homo sapiens	28-33
33469455-6	2020	This activated phenotype was confirmed experimentally by incubating healthy control neutrophils in cell-free RA SF, which was able to delay apoptosis and induce ROS production in both unprimed and TNFalpha primed neutrophils (p<0.05).	ros	161-164	tumor necrosis factor	Homo sapiens	197-205
33430172-7	2021	The generation of superoxide and hydrogen peroxide was increased in aortas from CETP transgenic mice, while silencing CETP in cultured human aortic endothelial cells effectively decreased oxidative stress promoted by all major sources of ROS: mitochondria and NOX2.	ros	238-241	cholesteryl ester transfer protein	Homo sapiens	118-122
33397994-5	2021	IR-61 inhibits the classical activation of ATMs by increasing mitochondrial complex levels and oxidative phosphorylation via the ROS/Akt/Acly pathway.	ros	129-132	AKT serine/threonine kinase 1	Homo sapiens	133-136
33393494-6	2021	Loss of DYRK1A-mediated FOXO1 and STAT3 signaling disrupted DNA damage and ROS regulation, respectively, leading to preferential cell death in leukemic B cells.	ros	75-78	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	8-14
33393494-6	2021	Loss of DYRK1A-mediated FOXO1 and STAT3 signaling disrupted DNA damage and ROS regulation, respectively, leading to preferential cell death in leukemic B cells.	ros	75-78	forkhead box O1	Homo sapiens	24-29
33393494-6	2021	Loss of DYRK1A-mediated FOXO1 and STAT3 signaling disrupted DNA damage and ROS regulation, respectively, leading to preferential cell death in leukemic B cells.	ros	75-78	signal transducer and activator of transcription 3	Homo sapiens	34-39
32640963-0	2021	Periplogenin Activates ROS-ER Stress Pathway to Trigger Apoptosis via BIP-eIF2alpha-CHOP and IRE1alpha-ASK1-JNK Signaling Routes.	ros	23-26	heat shock protein family A (Hsp70) member 5	Homo sapiens	70-73
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	ros	52-55	heat shock protein family A (Hsp70) member 5	Homo sapiens	65-68
33144123-7	2021	The p62-Keap1-Nrf2 positive feedback loop and the Nrf2 pathway are involved in eliminating the ROS and protein aggregates induced by AD.	ros	95-98	kelch like ECH associated protein 1	Homo sapiens	8-13
33144123-7	2021	The p62-Keap1-Nrf2 positive feedback loop and the Nrf2 pathway are involved in eliminating the ROS and protein aggregates induced by AD.	ros	95-98	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
33144123-7	2021	The p62-Keap1-Nrf2 positive feedback loop and the Nrf2 pathway are involved in eliminating the ROS and protein aggregates induced by AD.	ros	95-98	NFE2 like bZIP transcription factor 2	Homo sapiens	50-54
33569429-11	2021	Furthermore, the expression levels of RANKL and RANK were increased, while OPG expression was reduced after treatment with VIP in the co-culture of ROS 17/2.8 and rat BMMs.	ros	148-151	vasoactive intestinal peptide	Rattus norvegicus	123-126
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	ros	52-55	DNA damage inducible transcript 3	Homo sapiens	79-83
33397259-8	2021	Molecular investigations have revealed that the NF-kappaB suppression, Notch 1 inhibition, cell cycle stop at S+G2/M-phase, enhanced Bax protein concentrations, mitochondrial membrane potential attenuation, activation of p53 and caspase, Bcl-2 regulation, and ROS formation are crucial mechanisms that could be targeted via various Artemisia species.	ros	260-263	BCL2 apoptosis regulator	Homo sapiens	238-243
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	ros	52-55	heat shock protein family A (Hsp70) member 5	Homo sapiens	88-91
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	ros	52-55	mitogen-activated protein kinase 8	Homo sapiens	97-100
33065288-6	2021	Furthermore, BMDMs from mice with macrophage specific-deletion of Hdac4 (Hdac4MKO) showed significant decreases in ethanol-induced inflammatory genes and ROS accumulation but an increase in Sirt1 expression.	ros	154-157	histone deacetylase 4	Mus musculus	66-71
33065288-6	2021	Furthermore, BMDMs from mice with macrophage specific-deletion of Hdac4 (Hdac4MKO) showed significant decreases in ethanol-induced inflammatory genes and ROS accumulation but an increase in Sirt1 expression.	ros	154-157	histone deacetylase 4	Mus musculus	73-81
33246054-7	2021	Moreover, our data revealed that multiple signaling pathways were involved in the H3K4 trimethylation of TNFR1 and TRAIL proteins by CIL-102, including ROS-derived and JNK/mTOR/p300 pathways in gastric cancer AGS cells.	ros	152-155	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	105-110
33074353-2	2021	TSPO has been shown to be related to the generation of ROS and is involved in regulating inflammation, whether uric acid drives intestinal epithelial dysfunction through TSPO-mediated NLRP3 inflammasome activation is unknown.	ros	55-58	translocator protein	Mus musculus	0-4
33969677-6	2021	In this study, we found that inhibition of ASC reduced the expression of inflammatory cytokines, and the concentration of calcium and ROS, while it increased the expression of mitochondrial function-related proteins.	ros	134-137	PYD and CARD domain containing	Homo sapiens	43-46
33597103-0	2021	Corrigendum to "Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation" [Free Radic.	ros	113-116	proopiomelanocortin	Homo sapiens	16-35
33248265-5	2021	In contrast to the predicted neuroprotective role of Nrf2 in oxidative stress-related diseases, we found that Nrf2 KO remarkably improved the motor coordination of aged mice, which was associated with the reduced ROS level and decreased apoptosis of dopaminergic neurons in substantia nigra (SN) of 18-month-old Nrf2 KO mice.	ros	213-216	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
33248265-5	2021	In contrast to the predicted neuroprotective role of Nrf2 in oxidative stress-related diseases, we found that Nrf2 KO remarkably improved the motor coordination of aged mice, which was associated with the reduced ROS level and decreased apoptosis of dopaminergic neurons in substantia nigra (SN) of 18-month-old Nrf2 KO mice.	ros	213-216	nuclear factor, erythroid derived 2, like 2	Mus musculus	110-114
32776282-8	2021	ROS oxidatively modifies Keap1 to release NRF2 and allow its nuclear translocation.	ros	0-3	kelch like ECH associated protein 1	Homo sapiens	25-30
32776282-8	2021	ROS oxidatively modifies Keap1 to release NRF2 and allow its nuclear translocation.	ros	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	42-46
33074353-15	2021	Silencing TSPO suppressed NLRP3 inflammasome activation and increased expression of claudin-1 and occludin, which was accompanied by lower levels of ROS.	ros	149-152	translocator protein	Mus musculus	10-14
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	11-14	translocator protein	Mus musculus	114-118
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	175-178	translocator protein	Mus musculus	114-118
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	ros	47-50	catalase	Homo sapiens	158-166
33278745-10	2021	The promoted ROS level and inhibited GSH level in the astrocytes by the stimulation with Ang II were significantly reversed by Ferrostatin-1.	ros	13-16	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	89-95
33278745-12	2021	CONCLUSION: Ferrostatin-1 alleviates angiotensin II (Ang II)- induced inflammation and ferroptosis by suppressing the ROS levels and activating the Nrf2/HO-1 signaling pathway.	ros	118-121	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	37-51
33278745-12	2021	CONCLUSION: Ferrostatin-1 alleviates angiotensin II (Ang II)- induced inflammation and ferroptosis by suppressing the ROS levels and activating the Nrf2/HO-1 signaling pathway.	ros	118-121	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	53-59
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	ros	47-50	catalase	Homo sapiens	168-171
33693448-14	2021	ROS scavengers GPx-3 and GPx-7 were ~50% lower in LLC hearts.	ros	0-3	glutathione peroxidase 3	Homo sapiens	15-20
33242555-13	2021	These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release.	ros	156-159	heme oxygenase 1	Mus musculus	122-126
33157090-13	2021	SIGNIFICANCE: We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis, and pointed out that curcumol targeted ROS/ERK-mediated KLF5 expression could inhibit LSEC angiogenesis.	ros	183-186	mitogen-activated protein kinase 1	Mus musculus	187-190
33171331-0	2021	Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling.	ros	63-66	fibroblast growth factor receptor 1	Homo sapiens	76-81
33171331-5	2021	We further showed that exogenous ROS such as hydrogen peroxide alone was sufficient to activate FGFR1 and induce PD-L1, while antioxidants could largely abrogate PD-L1 expression in K-ras mutant cells, indicating a critical role of redox regulation.	ros	33-36	fibroblast growth factor receptor 1	Homo sapiens	96-101
33364504-6	2020	ROS triggered JNK and ERK phosphorylation, and cyt c release outside mitochondria, not accompanied by caspases-9 and -3 activation, probably due to 3BP-dependent alkylation of cysteine residues at caspase-9 catalytic site.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	14-17
33375816-13	2021	TXNIP may have negative association with TRX, and then decrease SOD activities and increase MDA levels, resulting in the upregulation of ROS and oxidative stress in HNECs, which may play a pivotal role in the pathogenesis of CRSwNP.	ros	137-140	thioredoxin interacting protein	Homo sapiens	0-5
33364504-6	2020	ROS triggered JNK and ERK phosphorylation, and cyt c release outside mitochondria, not accompanied by caspases-9 and -3 activation, probably due to 3BP-dependent alkylation of cysteine residues at caspase-9 catalytic site.	ros	0-3	mitogen-activated protein kinase 1	Homo sapiens	22-25
33097188-6	2020	In addition, GREM1 activated STAT3 transcription factor through the ROS-Akt signaling pathway.	ros	68-71	gremlin 1, DAN family BMP antagonist	Homo sapiens	13-18
33381272-7	2020	The cell model in vitro further demonstrated that p53 knockout or knockdown in the HCT116 cell and L02 cell significantly inhibited cell apoptosis and increased cell viability, presented by suppressing ROS production, oxidative stress, and the Nrf2/HO-1 pathway.	ros	202-205	tumor protein p53	Homo sapiens	50-53
33097188-6	2020	In addition, GREM1 activated STAT3 transcription factor through the ROS-Akt signaling pathway.	ros	68-71	signal transducer and activator of transcription 3	Homo sapiens	29-34
33097188-6	2020	In addition, GREM1 activated STAT3 transcription factor through the ROS-Akt signaling pathway.	ros	68-71	AKT serine/threonine kinase 1	Homo sapiens	72-75
33381228-6	2020	Our results showed that TNF-alpha could induce inflammatory damage to VECs, which manifested as upregulated expression of CD40, increased production of ROS, enhanced adhesion of THP-1 cells to VECs, and impaired viability and migration of VECs, while bazedoxifene could significantly reduce the endothelial damage caused by TNF-alpha.	ros	152-155	tumor necrosis factor	Homo sapiens	24-33
33424763-9	2020	ROS was activated, mitochondrial membrane potential and LC3-II/LC3-I ratio were decreased but P62 and BNIP3L/Nix were increased in hyperglycemia groups (P < 0.05), which were reversed by AMPK activation or mTOR inhibition.	ros	0-3	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	187-191
33318569-6	2020	miR-210 reconstitution restores the metabolic balance in diabetic wounds by reducing oxygen consumption rate and ROS production and by activating glycolysis with positive consequences on cellular migration.	ros	113-116	microRNA 210	Mus musculus	0-7
33298526-2	2021	Previous reports proposed that mitochondrial ROS production and disruption of the glutathione pool activate the Nrf2 pathway, suggesting that Nrf2 senses mitochondrial redox signals and/or oxidative damage and signals to the nucleus to respond appropriately.	ros	45-48	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
33305590-6	2021	Anti-apoptotic protein Bcl-2 was observed to be decreased by 62% at 20 microg/ml concentration and a significant increase in ROS production up to 6.9-fold was observed in time dependent manner.	ros	125-128	BCL2 apoptosis regulator	Homo sapiens	23-28
33318544-7	2020	Furthermore, inhibition of caspase-1 and NLRP3 activation increased neutrophil ROS-production, phagocytosis and the ability of neutrophils to suppress UPEC growth.	ros	79-82	caspase 1	Homo sapiens	27-36
33318544-7	2020	Furthermore, inhibition of caspase-1 and NLRP3 activation increased neutrophil ROS-production, phagocytosis and the ability of neutrophils to suppress UPEC growth.	ros	79-82	NLR family pyrin domain containing 3	Homo sapiens	41-46
33298526-2	2021	Previous reports proposed that mitochondrial ROS production and disruption of the glutathione pool activate the Nrf2 pathway, suggesting that Nrf2 senses mitochondrial redox signals and/or oxidative damage and signals to the nucleus to respond appropriately.	ros	45-48	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
33376580-8	2020	Furthermore, ROS inhibition attenuated HIF-1alpha expression and switched macrophage polarization from M1 to M2.	ros	13-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	39-49
33302580-7	2020	We demonstrated that the temporal treatment of HCT116 and MCF-7 cancer cells (both p53 wild-type) with DPI caused induction of senescence, that was correlated with decreased level of ROS and upregulation of p53/p21 proteins.	ros	183-186	tumor protein p53	Homo sapiens	83-86
33376580-9	2020	However, HIF-1alpha inhibition suppressed ROS expression and inhibited both the M1 phenotype and the M2 phenotype.	ros	42-45	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
33376580-10	2020	Inhibition of ROS or HIF-1alpha also suppressed the activation of the Akt/mTOR pathway, which was implicated in H. pylori-induced macrophage polarization.	ros	14-17	AKT serine/threonine kinase 1	Homo sapiens	70-73
33376580-10	2020	Inhibition of ROS or HIF-1alpha also suppressed the activation of the Akt/mTOR pathway, which was implicated in H. pylori-induced macrophage polarization.	ros	14-17	mechanistic target of rapamycin kinase	Homo sapiens	74-78
33206581-9	2021	In addition, gene silencing of HMOX1 caused upregulation of ROS production and suppression of the genes related to autophagy.	ros	60-63	heme oxygenase 1	Mus musculus	31-36
33376580-13	2020	Crosstalk between ROS and HIF-1alpha regulates H. pylori-induced macrophage polarization via the Akt/mTOR pathway.	ros	18-21	AKT serine/threonine kinase 1	Homo sapiens	97-100
33206581-10	2021	Moreover, inhibition of HIF1A (hypoxia inducible factor 1 subunit alpha) caused suppression of HMOX1 expression in MSC3D, indicating that the HIF1A-HMOX1 axis plays a crucial role in the modulation of ROS production and autophagy induction in MSC3D.	ros	201-204	heme oxygenase 1	Mus musculus	95-100
33206581-10	2021	Moreover, inhibition of HIF1A (hypoxia inducible factor 1 subunit alpha) caused suppression of HMOX1 expression in MSC3D, indicating that the HIF1A-HMOX1 axis plays a crucial role in the modulation of ROS production and autophagy induction in MSC3D.	ros	201-204	heme oxygenase 1	Mus musculus	148-153
33376580-13	2020	Crosstalk between ROS and HIF-1alpha regulates H. pylori-induced macrophage polarization via the Akt/mTOR pathway.	ros	18-21	mechanistic target of rapamycin kinase	Homo sapiens	101-105
33206581-12	2021	Taken together, these results indicated that autophagy activation and modulation of ROS production mediated via the HIF1A-HMOX1 axis play pivotal roles in enhancing the viability of MSC3D.	ros	84-87	heme oxygenase 1	Mus musculus	122-127
33344146-5	2020	The results showed that overexpression of ABCG1 by ABCG1 plasmid or liver X receptor (LXR) agonist T0901317 treatment inhibited ROS production and MDA content induced by H2O2 in HUAECs.	ros	128-131	ATP binding cassette subfamily G member 1	Homo sapiens	42-47
33213267-5	2021	As a result, the accumulation of damaged, ROS-generating mitochondria leads to activation of the NLRP3 inflammasome, which induces abnormal soluble cytokines secretion, then promotes the differentiation and maturation of osteoclasts, and ultimately results in bone metastasis.	ros	42-45	NLR family pyrin domain containing 3	Homo sapiens	97-102
33344146-5	2020	The results showed that overexpression of ABCG1 by ABCG1 plasmid or liver X receptor (LXR) agonist T0901317 treatment inhibited ROS production and MDA content induced by H2O2 in HUAECs.	ros	128-131	ATP binding cassette subfamily G member 1	Homo sapiens	51-56
32592323-0	2020	Novel beta-carboline-based indole-4,7-quinone derivatives as NQO1 inhibitor with potent antitumor activities by inducing ROS, apoptosis, and DNA damage.	ros	121-124	NAD(P)H quinone dehydrogenase 1	Homo sapiens	61-65
32602217-10	2020	Inhibition of LDHA with FX11 reduced lipogenesis, migration, proliferation and effector functions in RA CD8, while increasing ROS production 1.5-fold (p<0.03).	ros	126-129	lactate dehydrogenase A	Homo sapiens	14-18
32272856-5	2020	Our results outlined that ZnO/CNT@Fe3O4 decreased the proliferative capacity of K562 cells through induction of G1 arrest and induced apoptosis probably via ROS-dependent upregulation of FOXO3a and SIRT1.	ros	157-160	forkhead box O3	Homo sapiens	187-193
33172542-0	2020	Anti-inflammatory mechanisms of suppressors of cytokine signaling target ROS via NRF-2/thioredoxin induction and inflammasome activation in macrophages.	ros	73-76	NFE2 like bZIP transcription factor 2	Homo sapiens	81-86
33172542-4	2020	SOCS1 up-regulated an ROS-scavenging protein, thioredoxin, via enhanced expression and binding of NRF-2 to the thioredoxin promoter.	ros	22-25	NFE2 like bZIP transcription factor 2	Homo sapiens	98-103
33172542-7	2020	The results demonstrate that the anti-inflammatory mechanisms of SOCS1 and SOCS3 in macrophages are mediated via NRF-2-mediated thioredoxin upregulation resulting in the downregulation of ROS signal.Thus, our study supports the anti-oxidant role of SOCS1 and SOCS3 in the exquisite regulation of macrophage activation under oxidative stress.	ros	188-191	NFE2 like bZIP transcription factor 2	Homo sapiens	113-118
33152472-6	2020	Furthermore, AGL treatment caused G0/G1 phase arrest, reduced mitochondrial membrane potential (MMP), and upgraded intracellular ROS production.	ros	129-132	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	Homo sapiens	13-16
32918979-0	2020	TRIM32 regulates mitochondrial mediated ROS levels and sensitizes the oxidative stress induced cell death.	ros	40-43	tripartite motif containing 32	Homo sapiens	0-6
32918979-7	2020	The turnover of TRIM32 is enhanced during oxidative stress and its expression induces ROS generation, loss of mitochondrial transmembrane potential and decrease in complex-I activity.	ros	86-89	tripartite motif containing 32	Homo sapiens	16-22
32803561-7	2020	Moreover, the exogenous antioxidant application of the LA from the LCNs can prevent ROS damage, which was demonstrated by this study with the less myeloperoxidase (MPO) activity and decrease in cytokine levels (TNF-alpha and IL-1beta) generated by the oxidative stress modulation.	ros	84-87	myeloperoxidase	Homo sapiens	147-162
32803561-7	2020	Moreover, the exogenous antioxidant application of the LA from the LCNs can prevent ROS damage, which was demonstrated by this study with the less myeloperoxidase (MPO) activity and decrease in cytokine levels (TNF-alpha and IL-1beta) generated by the oxidative stress modulation.	ros	84-87	myeloperoxidase	Homo sapiens	164-167
32803561-7	2020	Moreover, the exogenous antioxidant application of the LA from the LCNs can prevent ROS damage, which was demonstrated by this study with the less myeloperoxidase (MPO) activity and decrease in cytokine levels (TNF-alpha and IL-1beta) generated by the oxidative stress modulation.	ros	84-87	tumor necrosis factor	Homo sapiens	211-220
33022360-9	2020	Restoration of physiological apoptosis by increasing the release of intracellular calcium to generate ROS thereby reducing the mitochondrial membrane potential for the release of cytochrome c and activation of caspase-3 was also reported with Imatinib administration.	ros	102-105	cytochrome c, somatic	Homo sapiens	179-191
33022360-9	2020	Restoration of physiological apoptosis by increasing the release of intracellular calcium to generate ROS thereby reducing the mitochondrial membrane potential for the release of cytochrome c and activation of caspase-3 was also reported with Imatinib administration.	ros	102-105	caspase 3	Homo sapiens	210-219
32931837-10	2020	Our analyses revealed that level of ROS production was higher in cervical cancer tissues and all cases characterized by mtND1 mutations.	ros	36-39	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	120-125
32931837-11	2020	CONCLUSIONS: We hypothesize that mutations in MT-ND1 observed in H-SIL and cancer could activate cervical carcinogenesis by increased ROS production.	ros	134-137	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	46-52
31838956-5	2020	Interestingly, after receiving ICT, some patients with EPO resistance have responded again to ESA treatment, with the decrease of the expression of SOCS1, apoptotic rates of CD71+ cells, ROS expression in CD71+ cells and the increase of the expression of STAT5 and BCL2L1.Conclusion: Iron overload can increase EPO resistance and the expression of SOCS1, inhibit the expression of STAT5 and BCL2L1.	ros	187-190	erythropoietin	Homo sapiens	55-58
32598967-9	2020	In the presence of unchanged TNF induced signaling, ROS-mediated calcium release from the ER caused mitochondrial permeability transition and apoptosis, which identified a link between extrinsic death receptor signaling and cell-intrinsic mitochondrial-mediated caspase activation.	ros	52-55	tumor necrosis factor	Mus musculus	29-32
32546016-2	2020	DETC is an inhibitor of the SOD1 enzyme, which leads to increased ROS production, important for the elimination of Leishmania.	ros	66-69	superoxide dismutase 1, soluble	Mus musculus	28-32
32488847-3	2020	Here, we first demonstrated that the JNK/p66Shc signal pathway promoted ROS generation and inhibited the anti-oxidation effect of FoxO3a to induce oxidative stress damage after SCI and the mechanism of electro-acupuncture in anti-oxidative stress.	ros	72-75	SHC adaptor protein 1	Rattus norvegicus	41-47
32910305-10	2020	Taken together, CpV may activate Ca2+-mediated oxidative signaling to produce excessive ROS acting as an endogenous agonist of TRPA1 channels in the peripheral terminals of the primary afferent neurons, resulting in persistent inflammatory pain.	ros	88-91	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	127-132
32640500-5	2020	ALA also up-regulated sensor genes of ROS signals, including HIF1A, FOXO1, FOXO3, ATM, PETEN, SIRT1, and SIRT3, during the process of hPSCs derived hemogenic endothelial cells generation.	ros	38-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-66
32640500-5	2020	ALA also up-regulated sensor genes of ROS signals, including HIF1A, FOXO1, FOXO3, ATM, PETEN, SIRT1, and SIRT3, during the process of hPSCs derived hemogenic endothelial cells generation.	ros	38-41	forkhead box O1	Homo sapiens	68-73
32488847-5	2020	Furthermore, p38MAPK-mediated microglia activation and inflammatory reaction and JNK/p66Shc-mediated ROS generation and oxidative stress damage were both attenuated by electro-acupuncture.	ros	101-104	SHC adaptor protein 1	Rattus norvegicus	85-91
32488847-7	2020	Therefore, the activation of JNK/p66Shc promoted the ROS-induced oxidative stress damage after SCI, and inhibiting the phosphorylation of p66Shc-mediated oxidative stress was the key target of electro-acupuncture to facilitate functional recovery SCI, but not p38MAPK.	ros	53-56	SHC adaptor protein 1	Rattus norvegicus	33-39
32488847-7	2020	Therefore, the activation of JNK/p66Shc promoted the ROS-induced oxidative stress damage after SCI, and inhibiting the phosphorylation of p66Shc-mediated oxidative stress was the key target of electro-acupuncture to facilitate functional recovery SCI, but not p38MAPK.	ros	53-56	SHC adaptor protein 1	Rattus norvegicus	138-144
33007364-10	2020	Taken together, VPA treatment enhances the expression and enzymatic activity of CYP2E1, which promotes ROS production and then causes CD36 and DGAT2 overproduction and hepatic steatosis in mice and LO2 cells, which provides a novel insight into VPA-induced hepatic steatosis.	ros	103-106	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	80-86
32270590-2	2020	In this study, we found that IGF-1 activated NF-kappaB and NLRP3 inflammatory signaling via IRS-1/mPGES-1/NOX2-regulated ROS.	ros	121-124	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	45-54
33243299-0	2020	Correction to: Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells.	ros	68-71	mitogen-activated protein kinase 8	Homo sapiens	82-85
33257471-9	2021	Hepatic KLF16 knockout impaired fatty acid oxidation, aggravated mitochondrial stress, ROS burden, advancing hepatic steatosis and insulin resistance.	ros	87-90	Kruppel-like factor 16	Mus musculus	8-13
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	ros	296-299	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
33097606-0	2020	Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway.	ros	74-77	mitogen-activated protein kinase 8	Homo sapiens	101-104
33246501-14	2020	Further studies showed that these changes in hAT-MSCs may be regulated by the ROS/MAPK/HIF-1alpha signaling pathway.	ros	78-81	hypoxia inducible factor 1 subunit alpha	Homo sapiens	87-97
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	ros	296-299	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
33243299-0	2020	Correction to: Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells.	ros	68-71	mitogen-activated protein kinase 1	Homo sapiens	90-93
33242213-3	2021	Noteworthy, transcriptional regulator NRF2 plays a key role in the cell antioxidant system, and many genes related to FPT are under the control of NRF2, including genes for iron regulation, thiol-dependent antioxidant system, enzymatic detoxification of RCS and carbonyls, NADPH regeneration and ROS sources from mitochondria or extra-mitochondria, which place NRF2 in the key position of regulating the ferroptotic death.	ros	296-299	NFE2 like bZIP transcription factor 2	Homo sapiens	147-151
33231566-9	2020	Silencing of Nrf2 enhanced the degree of apoptosis of EPCs as well as resulted in the impairment of EPC functions through inducing the promotion of (reactive oxygen species) ROS production.	ros	174-177	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
33239060-11	2020	TRPV1 inhibition increased mitochondrial calcium levels with subsequent mitochondrial ROS accumulation and depolarization.	ros	86-89	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
33241490-5	2021	Increased ROS generation and PI3K-Akt signaling can activate the receptor NRF2.	ros	10-13	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
33330441-0	2020	NDUFA4L2 Regulated by HIF-1alpha Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.	ros	132-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-32
32950687-6	2020	Besides, HSCARG regulates redox homeostasis via suppression of ROS and NO generation.	ros	63-66	NmrA like redox sensor 1	Homo sapiens	9-15
33305182-0	2020	STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction.	ros	90-93	signal transducer and activator of transcription 3	Homo sapiens	0-5
33239867-10	2020	Loxoprofen ameliorated Angiotensin II-induced production of ROS, reduced GSH, and NOX-2 and NOX-4 expression.	ros	60-63	angiotensinogen	Homo sapiens	23-37
33177495-8	2020	Further, this study demonstrates that quercetin reduces ROS via SIRT3-mediated acetylation of SOD2"s K68 residue.	ros	56-59	sirtuin 3	Homo sapiens	64-69
32540529-0	2020	Multiple 1-MCP treatment more effectively alleviated postharvest nectarine chilling injury than conventional one-time 1-MCP treatment by regulating ROS and energy metabolism.	ros	148-151	CD46 molecule	Homo sapiens	11-14
32540529-3	2020	Moreover, this study indicated that the reduction of CI in nectarine by 1-MCP application was related to its regulations of ROS and energy metabolism.	ros	124-127	CD46 molecule	Homo sapiens	74-77
32823004-5	2020	Preliminary mechanism studies indicated that compound 9o activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-kappaB/MAPK signaling pathway.	ros	112-115	NFE2 like bZIP transcription factor 2	Rattus norvegicus	67-71
33159039-0	2020	Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.	ros	85-88	poly (ADP-ribose) polymerase family, member 3	Mus musculus	0-5
33172280-4	2020	Here, we have developed degradable metallic complexes (PtH@FeP) containing an Fe(III)-polydopamine (FeP) core and HA-cross-linked CDDP (PtH) shell, exaggerating in situ toxic ROS production via the synergistic effect of CDDP and Fe(III).	ros	175-178	parathyroid hormone	Homo sapiens	55-58
33159039-5	2020	The accumulation of ROS contributes to the decreased activity of mTorc2 as a result of an oxidation-induced and Fbxw7-mediated ubiquitination and degradation of Rictor.	ros	20-23	F-box and WD-40 domain protein 7	Mus musculus	112-117
33294260-8	2020	Further, KRAS mutation CRC cells are resistant to Chiauranib by increasing Nrf2 to stably elevate the basal antioxidant program and thereby lower intracellular ROS induced by Chiauranib.	ros	160-163	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
32768820-0	2020	Chlorpyrifos induces the apoptosis and necroptosis of L8824 cells through the ROS/PTEN/PI3K/AKT axis.	ros	78-81	AKT serine/threonine kinase 1	Homo sapiens	92-95
33144519-5	2020	We also observed that p101VVKR777AAAA neutrophils showed enhanced p84-dependent ROS responses to fMLP and C5a, suggesting that competition may exist between p101/p110gamma and p84/p110gamma for Gbetagamma subunits downstream of GPCR activation.	ros	80-83	hemolytic complement	Mus musculus	106-109
33146789-10	2021	In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy.	ros	23-26	interleukin 6	Homo sapiens	171-175
33146789-10	2021	In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy.	ros	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	177-181
33049446-5	2020	Under salt stress, the SlSOS1/2 and SlNHX1 genes were highly expressed, and the accumulation of Na+ was lower in the transgenic seedlings than in WT, however, ROS accumulated to a greater degree in the former, and the ROS-scavenging-related enzyme activities and AsA content were lower in the transgenic seedlings than WT.	ros	159-162	Na+/H+ antiporter	Solanum lycopersicum	36-42
33035517-10	2020	Moreover, morusin treatment strikingly enhanced intracellular ROS level, an ROS scavenger NAC blocked cell death and changes of Akt, JNK and ERK induced by morusin.	ros	76-79	AKT serine/threonine kinase 1	Homo sapiens	128-131
33035517-10	2020	Moreover, morusin treatment strikingly enhanced intracellular ROS level, an ROS scavenger NAC blocked cell death and changes of Akt, JNK and ERK induced by morusin.	ros	76-79	mitogen-activated protein kinase 8	Homo sapiens	133-136
33035517-10	2020	Moreover, morusin treatment strikingly enhanced intracellular ROS level, an ROS scavenger NAC blocked cell death and changes of Akt, JNK and ERK induced by morusin.	ros	76-79	mitogen-activated protein kinase 1	Homo sapiens	141-144
33243934-11	2020	The TS-ROS-NF-kappaB regulatory axis actively involves in pemetrexed-induced PD-L1 upregulation, whereas when pemetrexed fails to induce PD-L1 expression in NSCLC cells, NF-kappaB signaling is unregulated.	ros	7-10	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	11-20
33243934-11	2020	The TS-ROS-NF-kappaB regulatory axis actively involves in pemetrexed-induced PD-L1 upregulation, whereas when pemetrexed fails to induce PD-L1 expression in NSCLC cells, NF-kappaB signaling is unregulated.	ros	7-10	CD274 antigen	Mus musculus	77-82
32592919-8	2020	It is known that the activation of endothelial estrogen receptors increases NO and decreases ROS, protecting the vascular system from angiotensin II-mediated vasoconstriction, inflammation, and ROS production.	ros	93-96	angiotensinogen	Homo sapiens	134-148
33010604-12	2020	CONCLUSION: In summary, miR-124-3p is upregulated in PE, and in vitro functional analysis revealed that this mRNA inhibits trophoblast invasion and migration but promotes cell pyroptosis partly via the PLGF-ROS pathway.	ros	207-210	placental growth factor	Homo sapiens	202-206
32979455-4	2020	Recent studies have provided insights on the localization of enzymes that synthesise reactive oxygen or nitrogen species (ROS or RNS respectively) in plasma membrane compartments (raft/caveolae) which also harbour PUFA esters, from which free acid forms can be released by phospholipase A2 activity (PLA2), and the complex of Nrf2 with the inhibitory protein Kelch-like ECH-associated Protein 1(Keap1).	ros	122-125	phospholipase A2 group IB	Homo sapiens	273-289
32979455-4	2020	Recent studies have provided insights on the localization of enzymes that synthesise reactive oxygen or nitrogen species (ROS or RNS respectively) in plasma membrane compartments (raft/caveolae) which also harbour PUFA esters, from which free acid forms can be released by phospholipase A2 activity (PLA2), and the complex of Nrf2 with the inhibitory protein Kelch-like ECH-associated Protein 1(Keap1).	ros	122-125	phospholipase A2 group IB	Homo sapiens	300-304
32979455-4	2020	Recent studies have provided insights on the localization of enzymes that synthesise reactive oxygen or nitrogen species (ROS or RNS respectively) in plasma membrane compartments (raft/caveolae) which also harbour PUFA esters, from which free acid forms can be released by phospholipase A2 activity (PLA2), and the complex of Nrf2 with the inhibitory protein Kelch-like ECH-associated Protein 1(Keap1).	ros	122-125	NFE2 like bZIP transcription factor 2	Homo sapiens	326-330
32979455-4	2020	Recent studies have provided insights on the localization of enzymes that synthesise reactive oxygen or nitrogen species (ROS or RNS respectively) in plasma membrane compartments (raft/caveolae) which also harbour PUFA esters, from which free acid forms can be released by phospholipase A2 activity (PLA2), and the complex of Nrf2 with the inhibitory protein Kelch-like ECH-associated Protein 1(Keap1).	ros	122-125	kelch like ECH associated protein 1	Homo sapiens	359-394
32979455-4	2020	Recent studies have provided insights on the localization of enzymes that synthesise reactive oxygen or nitrogen species (ROS or RNS respectively) in plasma membrane compartments (raft/caveolae) which also harbour PUFA esters, from which free acid forms can be released by phospholipase A2 activity (PLA2), and the complex of Nrf2 with the inhibitory protein Kelch-like ECH-associated Protein 1(Keap1).	ros	122-125	kelch like ECH associated protein 1	Homo sapiens	395-400
33002460-9	2020	In the upstream, ROS upregulation triggered by ART initiated AMPK-mTOR-ULK1 axis.	ros	17-20	mechanistic target of rapamycin kinase	Homo sapiens	66-70
32530119-3	2020	As results, quercetin showed contrasting dose-response to cellular behaviors dependent on the ROS-regulated p53 signaling pathways.	ros	94-97	tumor protein p53	Homo sapiens	108-111
33215444-14	2020	After H9c2 cells were transfected with miR-184 inhibitor to silence miR-184, the levels of ROS and MDA were markedly reduced, while the expression of SOD was greatly increased.	ros	91-94	microRNA 184	Rattus norvegicus	39-46
33215444-14	2020	After H9c2 cells were transfected with miR-184 inhibitor to silence miR-184, the levels of ROS and MDA were markedly reduced, while the expression of SOD was greatly increased.	ros	91-94	microRNA 184	Rattus norvegicus	68-75
32805340-5	2020	When HepG2 cells were pretreated with ROS (NAC) and ERS (4-PBA) inhibitors separately, the activation of NLRP3 inflammasome was inhibited.	ros	38-41	NLR family pyrin domain containing 3	Homo sapiens	105-110
33226363-6	2020	AngII decreased cell viability and PRDX6, upregulated the expression levels of TNF-alpha, IL-6, IL-1beta, LDH and MDA, stimulated ROS production, and reduced NO synthase, the expressions of eNOS, MnSOD, ICAM-1, VCAM-1, and activated the MAPK family of signaling proteins.	ros	130-133	angiotensinogen	Homo sapiens	0-5
32791262-7	2020	Moreover, NLRP3 siRNA shifted FeCl2-treated microglia from the M1 to the M2 cells, revealing that MitoQ-induce polarization states may be mediated by the mitochondrial ROS/NLRP-3 pathway.	ros	168-171	NLR family pyrin domain containing 3	Homo sapiens	10-15
33007531-11	2020	Under salt stress, alpha-TC shows stronger regulatory effect than gamma-TC through the impact on chloroplastic biosynthetic pathways and ROS/osmotic-modulating compounds.	ros	137-140	centroradiali	Arabidopsis thaliana	19-27
33049446-5	2020	Under salt stress, the SlSOS1/2 and SlNHX1 genes were highly expressed, and the accumulation of Na+ was lower in the transgenic seedlings than in WT, however, ROS accumulated to a greater degree in the former, and the ROS-scavenging-related enzyme activities and AsA content were lower in the transgenic seedlings than WT.	ros	218-221	Na+/H+ antiporter	Solanum lycopersicum	36-42
32838966-0	2020	Down-regulation of CRTAC1 attenuates UVB-induced pyroptosis in HLECs through inhibiting ROS production.	ros	88-91	cartilage acidic protein 1	Homo sapiens	19-25
33268575-19	2020	CONCLUSIONS: After I/R, HIF-1alpha up-regulates the expression of PGC1alpha, leading to an increase in ROS production and aggravation of injury.	ros	103-106	PPARG coactivator 1 alpha	Rattus norvegicus	66-75
33054172-6	2020	We confirmed that NP-upregulated HIF-1alpha protein expression was attributed to prolyl hydroxylase inhibition by both ROS and Zn2+.	ros	119-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-43
33105741-8	2020	Resulting from HPbetaCD antioxidant and anticytotoxic potential and protective capacity against ROS-induced PI3K/Akt signaling and HDAC2 inhibition, BUD:HPbetaCD might be more beneficial than BUD alone in a context of concomitant oxidative and inflammatory stress.	ros	96-99	AKT serine/threonine kinase 1	Homo sapiens	113-116
33149601-8	2020	We further found that DHA treatment and loss of PRIM2 reduced the GSH level and increased the cellular lipid ROS and mitochondrial MDA levels, and further downregulated the expressions of SLC7A11 and beta-catenin in lung cancer cells, respectively.	ros	109-112	DNA primase, p58 subunit	Mus musculus	48-53
33194716-9	2020	Taken together, Cos exerted autophagic and apoptotic effects on renal cancer through the ROS/JNK-dependent signal route.	ros	89-92	mitogen-activated protein kinase 8	Homo sapiens	93-96
33097055-8	2020	RESULTS: Here we showed that exposure to chemotherapeutic drug etoposide induces an exacerbation of ROS production which activates HIF-1alpha-mediated the metabolic reprogramming toward increased glycolysis and lactate production in non-small cell lung cancer (NSCLC).	ros	100-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
33105741-8	2020	Resulting from HPbetaCD antioxidant and anticytotoxic potential and protective capacity against ROS-induced PI3K/Akt signaling and HDAC2 inhibition, BUD:HPbetaCD might be more beneficial than BUD alone in a context of concomitant oxidative and inflammatory stress.	ros	96-99	histone deacetylase 2	Homo sapiens	131-136
33051434-7	2020	Interestingly, we found that the beta2-AR blockade affects Nrf2-Keap1 stability and its nuclear translocation leading to a drastic ROS increase and oxidative stress.	ros	131-134	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
33193477-10	2020	lox3 maize mutant plants react with an enhanced PAMP-triggered ROS burst implicating an enhanced defense response.	ros	63-66	linoleate 9S-lipoxygenase3	Zea mays	0-4
33193889-8	2020	Surfactin-induced mitochondrial-derived ROS generation was associated with JNK1/2 activation.	ros	40-43	mitogen-activated protein kinase 8	Homo sapiens	75-81
33193889-9	2020	After treatment with surfactin, ROS caused JNK1/2-dependent cell death of SCC4 and SCC25 cells.	ros	32-35	mitogen-activated protein kinase 8	Homo sapiens	43-49
33149809-12	2020	SIRT3, located in the mitochondria, can regulate ROS via different pathways.	ros	49-52	sirtuin 3	Homo sapiens	0-5
33194039-0	2020	PKCbeta increases ROS levels leading to vascular endothelial injury in diabetic foot ulcers.	ros	18-21	protein kinase C alpha	Homo sapiens	0-7
33194069-10	2020	Moreover, MPO and BAX levels were decreased by the hUC-MSC treatment, suggesting hUC-MSCs may play the role in inhibiting ROS production and apoptotic death in ALI repair.	ros	122-125	myeloperoxidase	Homo sapiens	10-13
32687961-8	2020	Akt inhibition decreased UPM-induced ROS formation and p38 and p65 protein phosphorylation, and restored the decreased ZO-1 and E-cadherin expression.	ros	37-40	AKT serine/threonine kinase 1	Homo sapiens	0-3
33123312-8	2020	In conclusion, despite that all three Nrf2 activators exerted some beneficial effects on the endothelium, as evidenced by a decrease in ROS production, bardoxolone methyl, the most potent Nrf2 activator among the tested compounds, displayed a distinct endothelial profile of activity comprising detrimental effects on mitochondria and cellular viability and suppression of endothelial ET-1 release possibly interfering with ET-1-dependent local regulation of endothelial permeability.	ros	136-139	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
33048003-5	2021	The in-vitro analysis clearly suggests that IL10-cRGD-Lip sustains the release of IL10 and could significantly reduce ROS and NO.	ros	118-121	interleukin 10	Mus musculus	44-48
33092166-3	2020	Emerging evidenceshows that ROS-mediated signal transduction can be regulated by selenoproteins such asmethionine sulfoxide reductase B1 (MsrB1).	ros	28-31	methionine sulfoxide reductase B1	Mus musculus	138-143
33088476-6	2020	We found that the H2O2-induced intracellular ROS level and the early cell apoptosis were attenuated in the HSP20- but not HSP20(Ala)- transfected cells.	ros	45-48	heat shock protein family B (small) member 6	Homo sapiens	107-112
32574911-6	2020	The resulted SBMA@EVOH NFMs exhibited integrated features of large ROS production capacity, ease of photoactive rechargeability and controllability, long-term stability, high biocidal efficacy (>99.9999% via contact killing), and promising antifouling performance, which enable the SBMA@EVOH NFMs to serve as a biocidal material for food safety and medical applications.	ros	67-70	androgen receptor	Homo sapiens	13-17
32758622-13	2020	SIGNIFICANCE: Bufothionine promoted GC cell death by triggering miR-133a-3p/IGF1R/PI3K/Akt axis mediated ER stress and ROS production.	ros	119-122	insulin-like growth factor I receptor	Mus musculus	76-81
32758622-13	2020	SIGNIFICANCE: Bufothionine promoted GC cell death by triggering miR-133a-3p/IGF1R/PI3K/Akt axis mediated ER stress and ROS production.	ros	119-122	thymoma viral proto-oncogene 1	Mus musculus	87-90
33057104-5	2020	The results showed that Hif-1aa played a role in tricarboxylic acid cycle by increasing the expression of Citrate synthase and the activity of mitochondrial complex II, and it also enhanced mitochondrial membrane potential and ROS production by reducing free Ca2+ in the cytosol.	ros	227-230	hypoxia inducible factor 1 subunit alpha a	Danio rerio	24-31
33051434-7	2020	Interestingly, we found that the beta2-AR blockade affects Nrf2-Keap1 stability and its nuclear translocation leading to a drastic ROS increase and oxidative stress.	ros	131-134	kelch like ECH associated protein 1	Homo sapiens	64-69
32599142-3	2020	We performed this study to evaluate the function of oxidative stress in NP and to explore the potential mechanism of ROS induced expression of matrix metalloproteinases (MMPs).	ros	117-120	matrix metallopeptidase 3	Homo sapiens	170-174
32683294-0	2020	Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	ros	85-88	occludin	Mus musculus	35-43
32683294-0	2020	Arsenite-induced downregulation of occludin in mouse lungs and BEAS-2B cells via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	ros	107-110	occludin	Mus musculus	35-43
32540758-7	2020	Moreover, the integrated ceria can perform robust SOD and CAT mimetic activities, which are capable of eliminating ROS and circumventing its oxidative damage to newborn neurons, leading to the longer survival rate and more enhanced outgrowth of the newborn neurons.	ros	115-118	catalase	Mus musculus	58-61
33012239-7	2021	Parkin overexpression enhanced the expression of anti-oxidative factors such as GSH, SOD and GPX, resulting into depressed ROS production.	ros	123-126	superoxide dismutase 1	Homo sapiens	85-88
32988895-7	2020	The simultaneous increase of antioxidant CAT enzyme with the decrease of plasma MDA may be an important ROS inhibiting mechanism to help patients return to normal antioxidant-oxidant status.	ros	104-107	catalase	Homo sapiens	41-44
32800851-7	2020	When miR-23a-5p was inhibited or PPARalpha gene was overexpressed, H/R-caused cell damage was alleviated and ROS level was decreased compared with NC group.	ros	109-112	peroxisome proliferator activated receptor alpha	Mus musculus	33-42
32738659-5	2020	Meanwhile, the intracellular ROS-P53 crosstalk can be upregulated by diallyl disulfide (up to 8-fold increase of ROS) and valproate (up to 18-fold increase of P53) to enhance early apoptosis.	ros	29-32	tumor protein p53	Homo sapiens	33-36
32738659-5	2020	Meanwhile, the intracellular ROS-P53 crosstalk can be upregulated by diallyl disulfide (up to 8-fold increase of ROS) and valproate (up to 18-fold increase of P53) to enhance early apoptosis.	ros	29-32	tumor protein p53	Homo sapiens	159-162
32738659-5	2020	Meanwhile, the intracellular ROS-P53 crosstalk can be upregulated by diallyl disulfide (up to 8-fold increase of ROS) and valproate (up to 18-fold increase of P53) to enhance early apoptosis.	ros	113-116	tumor protein p53	Homo sapiens	33-36
32738659-6	2020	The synchronization of enhanced G2/M arrest and ROS-P53 crosstalk devotes to reverse the cisplatin resistance with a high level of resistance reversion index (50.22).	ros	48-51	tumor protein p53	Homo sapiens	52-55
32738660-4	2020	We found that, compared to the non-biomimetic SeHANs, the B-SeHANs exhibited highly enhanced cellular internalization and intracellular degradation, and induced subsequent autophagy and caspase-dependent apoptosis via the ROS-mediated activation of the JNK pathway and inhibition of the Akt/mTOR pathway.	ros	222-225	mitogen-activated protein kinase 8	Homo sapiens	253-256
32738660-4	2020	We found that, compared to the non-biomimetic SeHANs, the B-SeHANs exhibited highly enhanced cellular internalization and intracellular degradation, and induced subsequent autophagy and caspase-dependent apoptosis via the ROS-mediated activation of the JNK pathway and inhibition of the Akt/mTOR pathway.	ros	222-225	AKT serine/threonine kinase 1	Homo sapiens	287-290
32738660-4	2020	We found that, compared to the non-biomimetic SeHANs, the B-SeHANs exhibited highly enhanced cellular internalization and intracellular degradation, and induced subsequent autophagy and caspase-dependent apoptosis via the ROS-mediated activation of the JNK pathway and inhibition of the Akt/mTOR pathway.	ros	222-225	mechanistic target of rapamycin kinase	Homo sapiens	291-295
32693110-10	2020	Neutrophil adherent to fibrinogen, but not to polylysine, were able to produce ROS upon lipopolysaccharide challenge and ROS production was completely suppressed upon inhibition of Pyk2.	ros	79-82	fibrinogen beta chain	Homo sapiens	23-33
32693110-10	2020	Neutrophil adherent to fibrinogen, but not to polylysine, were able to produce ROS upon lipopolysaccharide challenge and ROS production was completely suppressed upon inhibition of Pyk2.	ros	121-124	fibrinogen beta chain	Homo sapiens	23-33
32693110-11	2020	By contrast PMA-induced ROS production by neutrophil adherent to either fibrinogen or polylysine was independent from Pyk2.	ros	24-27	fibrinogen beta chain	Homo sapiens	72-82
32800851-9	2020	After enhancing miR-23a-5p expression or silencing PPARalpha gene, H/R-caused cell damage was further aggravated compared with NC group, and ROS level was increased associated with the decreased levels of FOXO3alpha, PGC-1alpha, Nrf2, CAT, NQO1, HO-1 and SOD2.	ros	141-144	peroxisome proliferator activated receptor alpha	Mus musculus	51-60
32800851-9	2020	After enhancing miR-23a-5p expression or silencing PPARalpha gene, H/R-caused cell damage was further aggravated compared with NC group, and ROS level was increased associated with the decreased levels of FOXO3alpha, PGC-1alpha, Nrf2, CAT, NQO1, HO-1 and SOD2.	ros	141-144	nuclear factor, erythroid derived 2, like 2	Mus musculus	229-233
32800851-9	2020	After enhancing miR-23a-5p expression or silencing PPARalpha gene, H/R-caused cell damage was further aggravated compared with NC group, and ROS level was increased associated with the decreased levels of FOXO3alpha, PGC-1alpha, Nrf2, CAT, NQO1, HO-1 and SOD2.	ros	141-144	catalase	Mus musculus	235-238
32800851-9	2020	After enhancing miR-23a-5p expression or silencing PPARalpha gene, H/R-caused cell damage was further aggravated compared with NC group, and ROS level was increased associated with the decreased levels of FOXO3alpha, PGC-1alpha, Nrf2, CAT, NQO1, HO-1 and SOD2.	ros	141-144	heme oxygenase 1	Mus musculus	246-250
32800851-9	2020	After enhancing miR-23a-5p expression or silencing PPARalpha gene, H/R-caused cell damage was further aggravated compared with NC group, and ROS level was increased associated with the decreased levels of FOXO3alpha, PGC-1alpha, Nrf2, CAT, NQO1, HO-1 and SOD2.	ros	141-144	superoxide dismutase 2, mitochondrial	Mus musculus	255-259
33004801-5	2020	Mechanistically, BAFF activated NLRP3 inflammasomes by promoting the association of cIAP-TRAF2 with components of NLRP3 inflammasomes, and by inducing Src activity-dependent ROS production and potassium ion efflux.	ros	174-177	NLR family pyrin domain containing 3	Homo sapiens	32-37
32607760-7	2020	In view of the key role of ROS on the Dox-induced cardiotoxicity, the relationship between ROS and NLRP3 was further investigated.	ros	91-94	NLR family, pyrin domain containing 3	Rattus norvegicus	99-104
32607760-9	2020	Decreasing ROS level by NAC can inhibit the NLRP3 inflammasome activation, secretion of IL-1beta and apoptosis in Dox-treating H9c2 cells and primary cardiomyocytes.	ros	11-14	NLR family, pyrin domain containing 3	Rattus norvegicus	44-49
32607760-9	2020	Decreasing ROS level by NAC can inhibit the NLRP3 inflammasome activation, secretion of IL-1beta and apoptosis in Dox-treating H9c2 cells and primary cardiomyocytes.	ros	11-14	interleukin 1 alpha	Rattus norvegicus	88-96
33224748-8	2020	As documented by flow cytometry, silencing of HIF1A-AS1 alleviated late apoptosis (5.1%+-2.8% vs. 17.2%+-4.2%, P<0.01) and ROS production (68.73%+-2.78% vs. 90.40%+-2.86%, P<0.01) compared to their levels in cardiomyocytes transfected with control siRNA.	ros	123-126	HIF1A antisense RNA 1	Homo sapiens	46-55
33004801-5	2020	Mechanistically, BAFF activated NLRP3 inflammasomes by promoting the association of cIAP-TRAF2 with components of NLRP3 inflammasomes, and by inducing Src activity-dependent ROS production and potassium ion efflux.	ros	174-177	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	151-154
32673631-5	2020	ASX treatment also markedly inhibited the production of ROS and activated PI3K/AKT signaling, which facilitated the nuclear translocation of Nrf-2 and reversed the down-regulation of HO-1, NQO1 and GCLM proteins in the hippocampus that were induced by sub-chronic exposure to La2O3 NPs.	ros	56-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-146
32180468-8	2020	Moreover, the expression of p-Erk/Nrf2/Trx-signaling pathway proteins was also up-regulated and the generation of ROS was decreased after LIRA treatment which was inhibited after treatment with U0126 (Erk inhibitor).	ros	114-117	mitogen-activated protein kinase 1	Homo sapiens	201-204
32470744-8	2020	Moreover, DAF-16 acted upstream of LGG-1, an ortholog of Atg8/LC3, to regulate the toxicity of nanopolystyrene toxicity in inducing ROS production and in decreasing locomotion behavior at adult day-9.	ros	132-135	Protein lgg-1	Caenorhabditis elegans	35-40
32682198-5	2020	Furthermore, as suggested by cellular mechanistic research concerning antitumor activity, the representative compound 4j resulted in ROS production depending on NQO1, then oxidative stress triggered apoptotic cell death.	ros	133-136	NAD(P)H quinone dehydrogenase 1	Homo sapiens	161-165
32451640-4	2020	Furthermore, PBM could activate mitochondrial ROS, which could elevate the phosphorylation levels of JNK and IKB in HGMSCs, and further activate NF-kappaB as the nuclear translocation of p65 is elevated.	ros	46-49	mitogen-activated protein kinase 8	Homo sapiens	101-104
32786113-11	2020	Moreover AOPPs activated the accumulated FOXO3a by maintaining FOXO3a in the nucleus, and this process was dependent on ROS-mediated AKT signaling deactivation.	ros	120-123	AKT serine/threonine kinase 1	Homo sapiens	133-136
32786113-10	2020	Mechanistically, AOPPs increased the FOXO3a protein levels by inhibiting their autophagic degradation in a ROS/mTOR-dependent manner.	ros	107-110	forkhead box O3	Homo sapiens	37-43
32786113-11	2020	Moreover AOPPs activated the accumulated FOXO3a by maintaining FOXO3a in the nucleus, and this process was dependent on ROS-mediated AKT signaling deactivation.	ros	120-123	forkhead box O3	Homo sapiens	41-47
32994511-9	2020	Our study mechanistically demonstrates that ADMA is involved in the progression of kidney cell injury under high glucose condition by targeting coordinated complex mechanisms involving the NOX4- ROS-ERK pathway.	ros	195-198	mitogen-activated protein kinase 1	Homo sapiens	199-202
32707370-14	2020	It is of advantage to prevent apoptosis through SIRT3-mediated SOD2 deacetylation that reduces ROS accumulation and restores mitochondrial function.	ros	95-98	sirtuin 3	Homo sapiens	48-53
33242767-4	2020	In proliferating and differentiating neuroblastoma (Neuro 2a/N2a) cells, sulforaphane-mediated Nrf2 activation resulted in increased transcription/translation of antioxidants and glutathione (GSH) production along with significantly declined ROS in a dose-dependent manner leading to a reductive-redox state (i.e. RS).	ros	242-245	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
33134292-7	2020	Furthermore, 10 muM CXB counteracted the Abeta-induced ROS production with a mechanism fully dependent on HO-1 up-regulation; nevertheless, 10 muM CXB significantly counteracted only 25 nM sAbeta-induced lipid peroxidation damage in SH-SY5Y neurons by modulating HO-1.	ros	55-58	amyloid beta precursor protein	Homo sapiens	41-46
33134292-8	2020	Both carbon monoxide (CORM-2, 50 nM) and bilirubin (50 nM) significantly prevented ROS production in Abeta-treated neurons and favored both the slowdown of the growth rate of Abeta oligomers and the decrease in oligomer/fibril final size.	ros	83-86	amyloid beta precursor protein	Homo sapiens	101-106
32929153-0	2020	Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.	ros	63-66	NFE2 like bZIP transcription factor 2	Homo sapiens	75-79
32929153-6	2020	Regarding the mechanism involved, TRIM2 activated ROS-related E2-related factor 2 (NRF2)/antioxidant response element (ARE) signaling and the integrin/focal adhesion kinase (FAK) pathway.	ros	50-53	NFE2 like bZIP transcription factor 2	Homo sapiens	83-87
32929153-11	2020	TRIM2 accelerates pancreatic cancer progression via the ROS-related NRF2/ITGB7/FAK axis.	ros	56-59	NFE2 like bZIP transcription factor 2	Homo sapiens	68-72
33059314-5	2020	Mechanistically, we demonstrate that deficiency of USF2 promotes survival by inducing mitophagy in a ROS-sensitive manner by activating both ERK1/2 and AKT.	ros	101-104	mitogen-activated protein kinase 3	Homo sapiens	141-147
33059314-5	2020	Mechanistically, we demonstrate that deficiency of USF2 promotes survival by inducing mitophagy in a ROS-sensitive manner by activating both ERK1/2 and AKT.	ros	101-104	AKT serine/threonine kinase 1	Homo sapiens	152-155
33003464-8	2020	rho- petites expressing alpha-synuclein from fully-induced MET25/GAL1 promoters exhibit increased ROS levels, loss of mitochondrial membrane potential, and nuclear DNA fragmentation, with increasing copies of alpha-synuclein.	ros	98-101	bifunctional cysteine synthase/O-acetylhomoserine aminocarboxypropyltransferase MET17	Saccharomyces cerevisiae S288C	59-64
32909594-4	2020	Fluorescence measurement demonstrated that GUB (at a concentration of 30 muM) significantly reduced the intracellular ROS levels in APAP-treated HepG2 cells.	ros	118-121	DExD-box helicase 50	Homo sapiens	43-46
33132847-0	2020	Parvalbumin-Deficiency Accelerates the Age-Dependent ROS Production in Pvalb Neurons in vivo: Link to Neurodevelopmental Disorders.	ros	53-56	parvalbumin	Mus musculus	71-76
32985606-7	2020	Notably, all these events were reverted by N-acetyl-L-cysteine and JNK inhibitor SP600125 furnishing evidence that APE exerted its effects through the activation of ROS/JNK signaling.	ros	165-168	mitogen-activated protein kinase 8	Homo sapiens	67-70
32985606-7	2020	Notably, all these events were reverted by N-acetyl-L-cysteine and JNK inhibitor SP600125 furnishing evidence that APE exerted its effects through the activation of ROS/JNK signaling.	ros	165-168	mitogen-activated protein kinase 8	Homo sapiens	169-172
32973326-0	2021	Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling.	ros	113-116	signal transducer and activator of transcription 3	Mus musculus	107-112
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	ros	277-280	nuclear factor kappa B subunit 1	Homo sapiens	33-42
32977573-10	2020	Moreover, pretreatment of sauchinone inhibited NF-kappaB translocation and ROS production in AngII-exposed mesangial cells.	ros	75-78	angiotensinogen	Homo sapiens	93-98
32963243-4	2020	In this study, we explored the role of H2AX phosphorylation at Ser139 alone or in combination with MAP17 protein, an inducer of DNA damage through ROS increase, as prognostic biomarkers in sarcoma tumors.	ros	147-150	PDZK1 interacting protein 1	Homo sapiens	99-104
32931452-0	2020	Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury.	ros	19-22	AKT serine/threonine kinase 1	Homo sapiens	58-61
32779670-0	2020	Photo-induced specific intracellular release EGFR inhibitor from enzyme/ROS-dual sensitive nano-platforms for molecular targeted-photodynamic combinational therapy of non-small cell lung cancer.	ros	72-75	epidermal growth factor receptor	Homo sapiens	45-49
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	ros	57-60	caspase 3	Homo sapiens	108-117
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	ros	57-60	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	ros	57-60	BCL2 apoptosis regulator	Homo sapiens	144-149
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	ros	220-223	caspase 3	Homo sapiens	108-117
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	ros	220-223	BCL2 associated X, apoptosis regulator	Homo sapiens	122-125
32948186-8	2020	The results of Annexin V-FITC/PI, JC-1, Western blot and ROS analysis showed that the expression of cleaved caspase-3 and Bax were up-regulated Bcl-2 was down-regulated in Cepharanthine or Curcumin treated groups, while ROS and MMP value were decreased at different degrees and the apoptosis rate was reduced.	ros	220-223	BCL2 apoptosis regulator	Homo sapiens	144-149
32812423-5	2020	The above results support that depending on intracellular copper and iron ions, 3,4-DHB, a pro-electrophile, can be converted into its corresponding o-quinone electrophile together with the generation of ROS, a pro-oxidative event that mediates its inhibitory activity against NF-kappaB signaling and inflammation.	ros	204-207	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	277-286
32473132-10	2020	Increased ROS accumulation activated ERK-1/2 which stabilized nuclear HIF-1alpha, promoting bnip3-mediated apoptosis.	ros	10-13	mitogen-activated protein kinase 3	Homo sapiens	37-44
32473132-10	2020	Increased ROS accumulation activated ERK-1/2 which stabilized nuclear HIF-1alpha, promoting bnip3-mediated apoptosis.	ros	10-13	hypoxia inducible factor 1 subunit alpha	Homo sapiens	70-80
32473132-10	2020	Increased ROS accumulation activated ERK-1/2 which stabilized nuclear HIF-1alpha, promoting bnip3-mediated apoptosis.	ros	10-13	BCL2 interacting protein 3	Homo sapiens	92-97
32473132-13	2020	NO-stabilized HIF-1alpha was predominantly cytosolic, since low ROS levels downregulated ERK-1/2 activity, thereby suppressing bnip3 expression.	ros	64-67	mitogen-activated protein kinase 3	Homo sapiens	89-96
32473132-13	2020	NO-stabilized HIF-1alpha was predominantly cytosolic, since low ROS levels downregulated ERK-1/2 activity, thereby suppressing bnip3 expression.	ros	64-67	BCL2 interacting protein 3	Homo sapiens	127-132
32473132-17	2020	CONCLUSION: ROS-mediated HIF-1alpha stabilization promotes cardiomyocyte apoptosis on one hand while NO-mediated stabilization of HIF-1alpha disrupts apoptosis depending upon the severity and duration of hypoxia.	ros	12-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-35
33042402-0	2020	Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK/ERK signaling pathway.	ros	117-120	mitogen-activated protein kinase 1	Homo sapiens	138-141
32931452-0	2020	Taurine suppresses ROS-dependent autophagy via activating Akt/mTOR signaling pathway in calcium oxalate crystals-induced renal tubular epithelial cell injury.	ros	19-22	mechanistic target of rapamycin kinase	Homo sapiens	62-66
33042402-13	2020	In vitro, hucMSC-Ex significantly inhibited TGF-beta1-induced apoptosis of NRK-52E cells by altering the production of ROS.	ros	119-122	transforming growth factor, beta 1	Rattus norvegicus	44-53
32931452-11	2020	In summary, the current study shows that taurine inhibits ROS-dependent autophagy via activating Akt/mTOR signaling pathway in CaOx crystals-induced HK-2 cell and kidney injury, suggesting that taurine may serve as an effective therapeutic agent for the treatment of CaOx nephrolithiasis.	ros	58-61	AKT serine/threonine kinase 1	Homo sapiens	97-100
33042402-15	2020	In conclusion, the results showed that hucMSC-Ex had positive effects towards UUO-induced renal fibrosis and apoptosis of renal tubular epithelial cells, and its mechanism of action was associated with inhibition of ROS-mediated p38MAPK/ERK signaling pathway.	ros	216-219	Eph receptor B1	Rattus norvegicus	237-240
32931452-11	2020	In summary, the current study shows that taurine inhibits ROS-dependent autophagy via activating Akt/mTOR signaling pathway in CaOx crystals-induced HK-2 cell and kidney injury, suggesting that taurine may serve as an effective therapeutic agent for the treatment of CaOx nephrolithiasis.	ros	58-61	mechanistic target of rapamycin kinase	Homo sapiens	101-105
32442565-7	2020	Treatment of SNF7 dose-dependently attenuated CFD-induced surge of intracellular ROS levels in keratinocytes by increasing antioxidant defense enzymes.	ros	81-84	charged multivesicular body protein 4A	Homo sapiens	13-17
32982300-0	2020	The NRF2/KEAP1 Pathway Modulates Nasopharyngeal Carcinoma Cell Radiosensitivity via ROS Elimination.	ros	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
32982300-0	2020	The NRF2/KEAP1 Pathway Modulates Nasopharyngeal Carcinoma Cell Radiosensitivity via ROS Elimination.	ros	84-87	kelch like ECH associated protein 1	Homo sapiens	9-14
32916152-10	2020	Ablation of YY1 led to defective ATP production and mitochondrial ROS accumulation in pancreatic beta-cells.	ros	66-69	YY1 transcription factor	Mus musculus	12-15
32897469-7	2020	At the same time, reactive oxygen (ROS) generated from intracellularly delivered Ce6 by laser irradiation arrested the activity of ABCG2 efflux receptor overexpressed in doxorubicin-resistant breast cancer cells (MCF-7/ADR), resulting in increased the chemotherapy efficacy.	ros	35-38	aldo-keto reductase family 1 member B	Homo sapiens	219-222
32983087-9	2020	When neutrophil derived, C5a-induced MV were exposed to a complex ex vivo whole blood model significant pro-inflammatory properties (NADPH activity, ROS and MPO generation) of the MVs became evident.	ros	149-152	complement C5a receptor 1	Homo sapiens	25-28
32889782-7	2020	Reduction in ROS resulted in the suppression of inflammatory signals (p-NF-kappaB and IL-6).	ros	13-16	interleukin 6	Rattus norvegicus	86-90
33013353-0	2020	Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca+2 Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells.	ros	86-89	mitogen-activated protein kinase 8	Homo sapiens	14-17
32516539-5	2020	In addition, mitochondrial ROS production has been suggested to regulate skeletal muscle insulin sensitivity, which may also be influenced by PGC-1alpha.	ros	27-30	insulin	Homo sapiens	89-96
32516539-5	2020	In addition, mitochondrial ROS production has been suggested to regulate skeletal muscle insulin sensitivity, which may also be influenced by PGC-1alpha.	ros	27-30	PPARG coactivator 1 alpha	Homo sapiens	142-152
32473481-5	2020	The resulted ROS could induce DNA damage of the tumor cells, thus enhancing the sensitivity to the inhibitor of NAMPT (FK866) to downregulate NAD/ERK/NF-kappaB signal pathways, and eventually simultaneously prevent cancer progression.	ros	13-16	mitogen-activated protein kinase 1	Homo sapiens	146-149
32687844-0	2020	The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway.	ros	45-48	tumor protein p53	Homo sapiens	121-124
32697943-6	2020	The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) and consequently promotes glycolysis.	ros	37-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-115
32697943-6	2020	The infection triggers mitochondrial ROS production, which induces stabilization of hypoxia-inducible factor-1alpha (HIF-1alpha) and consequently promotes glycolysis.	ros	37-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	117-127
32687844-12	2020	In addition to upregulation of p53, its down-stream targets, AKT/mTor were also downregulated, supporting that DpdtC induced EMT inhibition was achieved through ferritinophagy-ROS vicious cycle mediated p53/AKT/mTor pathway.	ros	176-179	tumor protein p53	Homo sapiens	203-206
32687844-0	2020	The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway.	ros	45-48	AKT serine/threonine kinase 1	Homo sapiens	125-128
32687844-0	2020	The vicious cycle between ferritinophagy and ROS production triggered EMT inhibition of gastric cancer cells was through p53/AKT/mTor pathway.	ros	45-48	mechanistic target of rapamycin kinase	Homo sapiens	129-133
32687844-9	2020	In addition, ferritinophagy triggers Fenton reaction, resulting in ROS production which give rise of p53 response, thus the role of p53 was further investigated.	ros	67-70	tumor protein p53	Homo sapiens	101-104
32705170-4	2020	In the present study, it was found dicoumarol (DIC) reduced the phosphorylation of pyruvate dehydrogenase (PDH) by inhibiting the activity of PDK1, which converted the metabolism of human hepatocellular carcinoma (HCC) cells to oxidative phosphorylation, leading to an increase in mitochondrial reactive oxygen species ROS (mtROS) and a decrease in mitochondrial membrane potential (MMP), thereby increasing the apoptosis induced by oxaliplatin (OXA).	ros	319-322	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	83-105
32619557-0	2020	Synergistic therapy with tangeretin and 5-fluorouracil accelerates the ROS/JNK mediated apoptotic pathway in human colorectal cancer cell.	ros	71-74	mitogen-activated protein kinase 8	Homo sapiens	75-78
32645628-7	2020	Furthermore, DL0410 attenuates inflammatory responses and ROS production in LPS-treated BV2 cells, which is responsible for Nrf2 and HO-1 up-regulation.	ros	58-61	nuclear factor, erythroid derived 2, like 2	Mus musculus	124-128
32645628-7	2020	Furthermore, DL0410 attenuates inflammatory responses and ROS production in LPS-treated BV2 cells, which is responsible for Nrf2 and HO-1 up-regulation.	ros	58-61	heme oxygenase 1	Mus musculus	133-137
32090638-5	2020	Pretreatment with Asc-2p significantly reduced the ROS production as well as increased the wound-healing indexes, Ki-67+rates and F-actin+ rates of the UVA irradiated wound-healing model.Conclusion: The migration of HCEnC plays a major role in the wound healing process of the established cell model, which is like the wound healing process in vivo.	ros	51-54	pyrin domain containing 1	Homo sapiens	18-24
32090638-6	2020	UVA decreases the wound closure of the in vitro HCEnC model dose-dependently, while antioxidant Asc-2p can attenuate the damage to UVA to HCEnCs probably via reducing ROS to improve their migration.	ros	167-170	pyrin domain containing 1	Homo sapiens	96-102
32293791-7	2020	In addition, NaF exposure increased the protein expression of p-ERK1/2 and decreased the protein expressions of Nrf2 and HO-1, as well as facilitated increasing ROS, 4-hydroxynonenal (4-HNE), and 8-Hydroxy-2"-deoxyguanosine (8-OHdG).	ros	161-164	C-X-C motif chemokine ligand 8	Homo sapiens	13-16
32592929-7	2020	The above mentioned results indicate that Lm-PHB2 could assist OPA1 and HAX1 to maintain mitochondrial morphology and decrease ROS levels by the translocation from the nucleus to mitochondria under oxidative stress.	ros	127-130	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	63-67
32593159-5	2020	In addition, as a new pro-inflammatory factor, the overexpression of CIRBP promotes the expression of inflammatory cytokines and oxidative stress as showing the production of iNOS and ROS in PRRSV-infected cells, which contributes to the inflammatory response via the NF-kappaB pathway.	ros	184-187	cold inducible RNA binding protein	Homo sapiens	69-74
32705170-4	2020	In the present study, it was found dicoumarol (DIC) reduced the phosphorylation of pyruvate dehydrogenase (PDH) by inhibiting the activity of PDK1, which converted the metabolism of human hepatocellular carcinoma (HCC) cells to oxidative phosphorylation, leading to an increase in mitochondrial reactive oxygen species ROS (mtROS) and a decrease in mitochondrial membrane potential (MMP), thereby increasing the apoptosis induced by oxaliplatin (OXA).	ros	319-322	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	107-110
32705806-8	2020	In addition, Andro also reduced TGF-beta1-induced intracellular ROS generation and NOX4 expression, and elevated antioxidant superoxide dismutase 2 (SOD2) expression, demonstrating the inhibiting effect of Andro on TGF-beta1-induced oxidative stress, which is closely linked to EMT.	ros	64-67	transforming growth factor beta 1	Homo sapiens	32-41
32898015-0	2020	SIRT3 Ablation Deteriorates Obesity-Related Cardiac Remodeling by Modulating ROS-NF-kappaB-MCP-1 Signaling Pathway.	ros	77-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
32716363-5	2020	beta-Glucan acted upstream of the NLRP3 inflammasome by preventing potassium (K+) efflux, mitochondrial ROS (mtROS) generation, and, ultimately, apoptosis-associated speck-like protein containing a CARD (ASC) oligomerization and speck formation.	ros	104-107	NLR family pyrin domain containing 3	Homo sapiens	34-39
32898015-0	2020	SIRT3 Ablation Deteriorates Obesity-Related Cardiac Remodeling by Modulating ROS-NF-kappaB-MCP-1 Signaling Pathway.	ros	77-80	mast cell protease 1	Mus musculus	91-96
32898015-9	2020	We presumed that SIRT3 ablation-mediated MCP-1 upregulation is attributed to ROS-NF-kappaB activation.	ros	77-80	mast cell protease 1	Mus musculus	41-46
32898015-9	2020	We presumed that SIRT3 ablation-mediated MCP-1 upregulation is attributed to ROS-NF-kappaB activation.	ros	77-80	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
32898015-10	2020	Thus, we concluded that SIRT3 prevents obesity-related cardiac remodeling by attenuating cardiac inflammation and fibrosis, through modulation of ROS-NF-kappaB-MCP-1 pathway.	ros	146-149	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
32898015-10	2020	Thus, we concluded that SIRT3 prevents obesity-related cardiac remodeling by attenuating cardiac inflammation and fibrosis, through modulation of ROS-NF-kappaB-MCP-1 pathway.	ros	146-149	mast cell protease 1	Mus musculus	160-165
32512641-12	2020	Knocked-down PLGF expression enhanced increased ROS production and decreased cell migration and invasion, which reverted to the original levels after PLGF was overexpressed.	ros	48-51	placental growth factor	Homo sapiens	13-17
32497629-2	2020	This work aimed to investigate possible influences of dimethyl fumarate (DMF) on streptozotocin (STZ) diabetes-associated vascular complications in rats, exploring its potential to modulate ROS-TXNIP-NLRP3 inflammasome pathway.	ros	190-193	NLR family, pyrin domain containing 3	Rattus norvegicus	200-205
32512010-8	2020	Collectively, our results demonstrates that HG-induced over production of ROS, disrupts the antioxidant defence mechanism and mitochondrial dysfunction, leading to alterations of inflammatory mediators and neurodegenerative markers through the ERK1/2-Akt-tuberin-mTOR dependent signalling pathway in RGC-5 cells.	ros	74-77	thymoma viral proto-oncogene 1	Mus musculus	251-254
32497629-15	2020	Collectively, these findings demonstrate that DMF offered vasculoprotective influences on diabetic aortas via attenuation of ROS-TXNIP-NLRP3 inflammasome pathway.	ros	125-128	NLR family, pyrin domain containing 3	Rattus norvegicus	135-140
32553926-8	2020	The enhanced expression of Pdx1 and insulin release in aged pancreatic islet cells reflects the extension of cell healthy aging due to the significant reduction of ROS.	ros	164-167	pancreatic and duodenal homeobox 1	Rattus norvegicus	27-31
32771169-4	2020	Overexpression of SlHSP17.7 showed a tolerant response to cold stress treatment due to an induce intracellular sucrose and less accumulation of ROS.	ros	144-147	17.8 kDa class I heat shock protein	Solanum lycopersicum	18-27
32387680-9	2020	Moreover, SFN and SFNAC suppressed ROS generation by activating antioxidant enzymes and Nrf2 signaling.	ros	35-38	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
32853879-5	2020	Notably, ME1 interference ultimately resulted in adaptive upregulation of mitochondrial IDH2 dependent of AMPK-FoxO1 activation to replenish the NADPH pool and mitigate cytosolic ROS.	ros	179-182	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	88-92
32853879-5	2020	Notably, ME1 interference ultimately resulted in adaptive upregulation of mitochondrial IDH2 dependent of AMPK-FoxO1 activation to replenish the NADPH pool and mitigate cytosolic ROS.	ros	179-182	forkhead box O1	Homo sapiens	111-116
32908936-6	2020	In addition, PRDX6 protected rat insulinoma RIN-m5F beta cells, cultured with TNF-alpha and IL-1beta, against the cytokine-induced cytotoxicity and reduced the apoptotic cell death and production of ROS.	ros	199-202	tumor necrosis factor	Rattus norvegicus	78-87
32599261-4	2020	Mitochondrial Cx43 can confer cardioprotection by regulating mitochondrial calcium homeostasis, ROS production and propagation of apoptotic signals, and studies report that it is overexpressed both in ischemic preconditioning and in Doxorubicin-induced cardiotoxicity.	ros	96-99	gap junction protein, alpha 1	Rattus norvegicus	14-18
32862153-7	2020	Furthermore, FRT reduced the concentrations of gamma-H2AX by decreasing ROS activation.	ros	72-75	H2A.X variant histone	Mus musculus	47-57
32872305-6	2020	Our data suggest that an increase of oxidative stress in Panc-1 cells activates a ROS-G4-PARP-1 axis that stimulates the transcription of KRAS.	ros	82-85	poly(ADP-ribose) polymerase 1	Homo sapiens	89-95
32824279-7	2020	Therefore, the results suggest that one of the possible antiproliferative mechanisms of HO-AAVPA is by HDAC1 inhibition which entails HMGB1 translocation and ROS increased levels that could trigger the cell apoptosis.	ros	158-161	histone deacetylase 1	Homo sapiens	103-108
32814770-9	2020	As a result, the phosphoresistant CypD S191A mutant was protected against 18 h starvation whereas cell death was significantly increased in phosphomimetic S191E group, associated with mitochondrial respiration alteration and ROS production.	ros	225-228	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	34-38
33061796-8	2020	It is concluded that the exacerbating effects of UCP2-/- on ischemic outcome in both normo- and hyperglycemic animals are associated with increased ROS production, disturbed mitochondrial dynamic balance towards fission and early damage to mitochondrial ultrastructure.	ros	148-151	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	49-53
32631508-4	2020	Further exploration of possible mechanism of action indicates that 13a not only activates ROS production through NQO1-directed redox cycling but also inhibits the phosphorylation of STAT3.	ros	90-93	NAD(P)H quinone dehydrogenase 1	Homo sapiens	113-117
32442538-7	2020	Under AGEs treatment conditions, USP9X overexpression markedly increased the total and nuclear levels, ARE-binding ability, and transcriptional activity of Nrf2, upregulated the protein expressions of Nrf2 downstream genes HO-1 and NQO1, and eventually reduced the excessive production of ROS.	ros	289-292	NFE2 like bZIP transcription factor 2	Rattus norvegicus	201-205
32562663-7	2020	After transfected with Sirt3 overexpression plasmid, we found that Sirt3 sensitized liver cancer cells to regorafenib and resulted in much more apoptosis with a significant increase of ROS level.	ros	185-188	sirtuin 3	Homo sapiens	23-28
32562663-7	2020	After transfected with Sirt3 overexpression plasmid, we found that Sirt3 sensitized liver cancer cells to regorafenib and resulted in much more apoptosis with a significant increase of ROS level.	ros	185-188	sirtuin 3	Homo sapiens	67-72
32562663-11	2020	The results demonstrated that Sirt3 overexpression promoted the increase of ROS and apoptosis induced by regorafenib through the acceleration of mitochondrial dysfunction by impairing function of the electron transport chain in liver cancer cells.	ros	76-79	sirtuin 3	Homo sapiens	30-35
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	ros	243-246	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	69-82
32913508-7	2020	With the decrease of ROS, JAK2/STAT3 signaling pathway and its downstream MMP2 and MMP9 expression were downregulated.	ros	21-24	signal transducer and activator of transcription 3	Homo sapiens	31-36
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	ros	243-246	solute carrier family 40 (iron-regulated transporter), member 1	Mus musculus	84-88
32913508-9	2020	Thus, we can conclude that ulinastatin attenuates adhesion molecules expression and monocyte-endothelial adhesion, mechanism of which is related that ulinastatin inhibits ROS transfer between the neighboring vascular endothelial cells mediated by Cx43, resulting in the inactivation of JAK2/STAT3 signaling pathway, and its downstream MMP2 and MMP9 expression decrease.	ros	171-174	signal transducer and activator of transcription 3	Homo sapiens	291-296
32450168-7	2020	In particularly, we found that the expression of iron export protein ferroportin 1 (Fpn1) in liver, spleen and small intestine all decreased in Nrf2-/- mice, which might account for the deposition of iron in different organs and the increased ROS.	ros	243-246	nuclear factor, erythroid derived 2, like 2	Mus musculus	144-148
32450168-9	2020	Our further investigation revealed that the increase of serum iron was due to the release of iron from the hemolysis of erythrocytes, which caused by the increased ROS level in red blood cells of the Nrf2-/- mice.	ros	164-167	nuclear factor, erythroid derived 2, like 2	Mus musculus	200-204
32203083-7	2020	Consistent with these in vivo experiment results, we found that pretreatment with FSH (50, 100 ng/mL) dose-dependently increased protein levels of GCLm and G6PD, and decreased the ROS production in N2a mouse neuroblastoma cells.	ros	180-183	follicle stimulating hormone beta	Mus musculus	82-85
32203083-8	2020	These findings demonstrate that FSH signaling is involved in pathogenesis of menopausal depression, and likely to maintain the redox-optimized ROS balance in neurons.	ros	143-146	follicle stimulating hormone beta	Mus musculus	32-35
32720163-6	2020	FA-inhibited TNF-alpha/CHX-induced apoptosis was determined by the quantification of TUNEL-positive cells, and the effect was associated with decreased ROS production and inhibited caspase3 activation.	ros	152-155	tumor necrosis factor	Rattus norvegicus	13-22
32128601-6	2020	Also, apelin protects against ALI/ARDS by reducing mitochondrial ROS-triggered oxidative damage, mitochondria apoptosis, and inflammatory responses induced by the activation of NF-kappaB and NLRP3 inflammasome.	ros	65-68	apelin	Homo sapiens	6-12
32305451-4	2020	We propose that maintenance of proper NADH/NAD+ and GSH/GSSG ratios are central to ameliorate insulin resistance, as alterations in these redox couples lead to complex I dysfunction, disruption of SIRT-3 activity, ROS production and impaired beta-oxidation, the latter two being key effectors of insulin resistance.	ros	214-217	insulin	Homo sapiens	94-101
32579956-3	2020	The increased expression of galectin-3 in TAMs was seen to be associated with nucleation of transcription factor NF-kappaB through generation and activation of ROS and promoted tumor growth and metastasis in vitro and in mice through multiple molecular mechanisms.	ros	160-163	lectin, galactose binding, soluble 3	Mus musculus	28-38
32579956-3	2020	The increased expression of galectin-3 in TAMs was seen to be associated with nucleation of transcription factor NF-kappaB through generation and activation of ROS and promoted tumor growth and metastasis in vitro and in mice through multiple molecular mechanisms.	ros	160-163	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
32128601-6	2020	Also, apelin protects against ALI/ARDS by reducing mitochondrial ROS-triggered oxidative damage, mitochondria apoptosis, and inflammatory responses induced by the activation of NF-kappaB and NLRP3 inflammasome.	ros	65-68	nuclear factor kappa B subunit 1	Homo sapiens	177-186
32128601-6	2020	Also, apelin protects against ALI/ARDS by reducing mitochondrial ROS-triggered oxidative damage, mitochondria apoptosis, and inflammatory responses induced by the activation of NF-kappaB and NLRP3 inflammasome.	ros	65-68	NLR family pyrin domain containing 3	Homo sapiens	191-196
32416091-12	2020	Inhibition of ACE and AP-N resulted in suppressed cell proliferation; repressed IARP, AT1R, and MAS1 expression; elevated ROS production; and increased IL-1beta, TNF-alpha, and IL-6 levels in HK2 cells.	ros	122-125	angiotensin I converting enzyme	Homo sapiens	14-17
33618464-4	2020	We reported that not only PM2.5-0.3, but also, to a lesser extent, its inorganic chemical fraction, NEM2.5-0.3, and organic chemical fraction, OEM2.5-0.3, were able to significantly induce ROS overproduction and oxidative damage notwithstanding the early activation of NRF2 signaling pathway.	ros	189-192	NFE2 like bZIP transcription factor 2	Homo sapiens	269-273
32402936-5	2020	Further results indicated that the ROS scavenging and cytoprotection effect of 3b might be related to the Nrf2 activation and upregulation of related phase II antioxidant enzymes, such as HO-1 and NQO1.	ros	35-38	NFE2 like bZIP transcription factor 2	Rattus norvegicus	106-110
32402936-5	2020	Further results indicated that the ROS scavenging and cytoprotection effect of 3b might be related to the Nrf2 activation and upregulation of related phase II antioxidant enzymes, such as HO-1 and NQO1.	ros	35-38	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	197-201
32289613-7	2020	When combined with immunofluorescence, Western blot analysis, and real-time RT-PCR analysis, this data showed that the mitochondrial-ROS-driven feed-forward loop increased phospho-PDGFRalpha/beta, which stimulates apoptosis by suppressing the PI3K-Akt pathway.	ros	133-136	platelet derived growth factor receptor alpha	Homo sapiens	180-195
32289613-7	2020	When combined with immunofluorescence, Western blot analysis, and real-time RT-PCR analysis, this data showed that the mitochondrial-ROS-driven feed-forward loop increased phospho-PDGFRalpha/beta, which stimulates apoptosis by suppressing the PI3K-Akt pathway.	ros	133-136	AKT serine/threonine kinase 1	Homo sapiens	248-251
32558367-7	2020	Meanwhile, ROS production regulated by UCP2 levels also contributed to NLRP3 inflammasome assembly and subsequent caspase 1 activation and mature IL-1beta secretion.	ros	11-14	NLR family, pyrin domain containing 3	Rattus norvegicus	71-76
32103437-6	2020	Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1beta secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger).	ros	228-231	NLR family pyrin domain containing 3	Homo sapiens	134-139
32103437-7	2020	Taken together, we presently show that Ti ions can activate NLRP3 inflammasome and then promote IL-beta secretion in vitro, where ROS may play a mechanistic role in this activation process.	ros	130-133	NLR family pyrin domain containing 3	Homo sapiens	60-65
32558367-7	2020	Meanwhile, ROS production regulated by UCP2 levels also contributed to NLRP3 inflammasome assembly and subsequent caspase 1 activation and mature IL-1beta secretion.	ros	11-14	interleukin 1 alpha	Rattus norvegicus	146-154
32710386-8	2020	Salvia species and Klasea species induced apoptosis via intracellular ROS generation secreted by TNF-alpha.	ros	70-73	tumor necrosis factor	Homo sapiens	97-106
32428596-7	2020	KEY FINDINGS: Although Sirt3 seemed to improve mitochondrial properties by increasing mitochondrial mass and potential, metabolic activity (Warburg effect) and antioxidative defense (SOD2, Cat), it also increased mitochondrial ROS, induced DNA damage, timp-1 expression, formation of multinucleated cells and apoptosis, and finally markedly reduced the proliferation of MDA-MB-231 cells.	ros	227-230	sirtuin 3	Homo sapiens	23-28
32437795-6	2020	Furthermore, mitochondrial fusion increased, while ATP consumption and ROS production decreased significantly after TLR4KO (P < .05).	ros	71-74	toll-like receptor 4	Mus musculus	116-120
32735635-9	2020	Results obtained via 8-isoprostane ELISA further indicated that inhibited ROS level was found in HepG2 cells transfected with SEPP1 over-expression plasmid.	ros	74-77	selenoprotein P	Homo sapiens	126-131
32676950-9	2020	On the contrary, Nrf2 inhibitor brusatol inhibited the nuclear transposition of Nrf2 and the expression levels of HO-1 and NQO-1 in hippocampal neurons, promoted the generation of ROS and NOX2, and accelerated cell apoptosis.	ros	180-183	NFE2 like bZIP transcription factor 2	Rattus norvegicus	17-21
32735635-11	2020	In conclusion, SEPP1 may inhibit the proliferation of HCC cells, accompanied by the reduction of ROS production and the increasing of GPX1 expression.	ros	97-100	selenoprotein P	Homo sapiens	15-20
32722164-3	2020	Nrf2 modulates virus-induced oxidative stress, ROS generation, and disease pathogenesis, which are vital in the viral life cycle.	ros	47-50	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
32848840-12	2020	Inhibition of CFTR, significantly increased intracellular ROS and H2O2 levels over 30 min and significantly decreased Nrf2 expression by 70% while increasing SOD-2 expression over 24 h. CFTR siRNA significantly increased constitutive expression of IL-8 by HLMVECs.	ros	58-61	CF transmembrane conductance regulator	Homo sapiens	14-18
32848840-12	2020	Inhibition of CFTR, significantly increased intracellular ROS and H2O2 levels over 30 min and significantly decreased Nrf2 expression by 70% while increasing SOD-2 expression over 24 h. CFTR siRNA significantly increased constitutive expression of IL-8 by HLMVECs.	ros	58-61	CF transmembrane conductance regulator	Homo sapiens	186-190
32774667-10	2020	With the downregulation of Cx43 expression, the activity of PKC-alpha and its related NOX2/ROS signaling pathway were reduced.	ros	91-94	protein kinase C alpha	Homo sapiens	60-69
32792943-6	2020	Further study of the underlying mechanism revealed that the two drugs in combination caused ROS aggregation in NSCLC cells, leading to DNA double-strand breaks and increased expression of the tumor suppressor factor p53.	ros	92-95	tumor protein p53	Homo sapiens	216-219
32708333-6	2020	We further elucidated the mechanism of action of necroptosis via receptor interacting protein kinase 3 (RIPK3) protein expression and it has been attributed by ROS generation through JNK activation.	ros	160-163	mitogen-activated protein kinase 8	Homo sapiens	183-186
32376267-9	2020	The reactive hepatic expression of HO-1 was related with the increased ROS production and ER stress, companied with upregulation of GRP78, p-IRE1, PERK, ATF6.	ros	71-74	heme oxygenase 1	Mus musculus	35-39
32765093-8	2020	Conclusion: Altogether, the outcome of the study for the first time revealed that TN exhibited its potential chemotherapeutic effects through ROS-mediated ER stress-induced apoptosis via p38 and ERK MAPK signaling pathways.	ros	142-145	mitogen-activated protein kinase 14	Homo sapiens	187-190
32765093-8	2020	Conclusion: Altogether, the outcome of the study for the first time revealed that TN exhibited its potential chemotherapeutic effects through ROS-mediated ER stress-induced apoptosis via p38 and ERK MAPK signaling pathways.	ros	142-145	mitogen-activated protein kinase 1	Homo sapiens	195-198
32660440-0	2020	IMMUNEPOTENT CRP induces DAMPS release and ROS-dependent autophagosome formation in HeLa and MCF-7 cells.	ros	43-46	C-reactive protein	Homo sapiens	13-16
32503939-6	2020	We also show that this perinuclear clustering of mitochondria results in the increased levels of ROS in the nucleus, leading to the activation of hypoxia-inducible factor-1alpha (HIF-1alpha).	ros	97-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-177
32503939-6	2020	We also show that this perinuclear clustering of mitochondria results in the increased levels of ROS in the nucleus, leading to the activation of hypoxia-inducible factor-1alpha (HIF-1alpha).	ros	97-100	hypoxia inducible factor 1 subunit alpha	Homo sapiens	179-189
32445887-0	2020	S-nitrosylation Control of ROS and RNS Homeostasis in Plants: the Switching Function of Catalase.	ros	27-30	catalase	Homo sapiens	88-96
32695257-10	2020	The activation of the NLRP3 inflammasome axis and the marked elevation of MDA, H2O2, and ROS levels were observed both in vivo and in vitro.	ros	89-92	NLR family, pyrin domain containing 3	Rattus norvegicus	22-27
32733520-11	2020	In addition, ROS participated in PIP1-induced stomatal closure and PIP1 could activate Ca2+ permeable channels.	ros	13-16	plasma membrane intrinsic protein 1A	Arabidopsis thaliana	33-37
32753868-5	2020	Subsequently, beta-Lapachone enhanced ROS levels by overexpressing NQO1, resulting in the transformation of BDOX into DOX.	ros	38-41	NAD(P)H quinone dehydrogenase 1	Homo sapiens	67-71
32630700-10	2020	ROS act as upstream signaling molecules to initiate apoptosis via p53/p21waf1 axis.	ros	0-3	tumor protein p53	Homo sapiens	66-69
32353423-14	2020	The ROS-activated FOXO3a cascade plays a central role in this process.	ros	4-7	forkhead box O3	Homo sapiens	18-24
32559840-8	2020	The subsequent ALOX15-mediated oxidative stress was decreased by CEP treatment in vivo and in vitro, as evidenced by reduced ROS generation and MDA level, and increased SOD activity.	ros	125-128	arachidonate 15-lipoxygenase	Mus musculus	15-21
32109431-6	2020	These includes the negatively regulated-Nrf2 by Keap1 that participates in HCC tumorigenesis via regulating ROS production, in which autophagy may contribute to oxidant metabolic reprogramming of HCC cells.	ros	108-111	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
32360554-6	2020	The blockage of GPR55 by its newly discovered antagonist-CID16020046 mitigated AGEs- induced increase in cellular ROS and decrease in antioxidant NRF2.	ros	114-117	G protein-coupled receptor 55	Homo sapiens	16-21
32138468-12	2020	PPARgamma suppressed VEGF/ FGF2 through ROS inhibition.	ros	40-43	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
32138468-12	2020	PPARgamma suppressed VEGF/ FGF2 through ROS inhibition.	ros	40-43	vascular endothelial growth factor A	Homo sapiens	21-25
32138468-12	2020	PPARgamma suppressed VEGF/ FGF2 through ROS inhibition.	ros	40-43	fibroblast growth factor 2	Homo sapiens	27-31
32109431-6	2020	These includes the negatively regulated-Nrf2 by Keap1 that participates in HCC tumorigenesis via regulating ROS production, in which autophagy may contribute to oxidant metabolic reprogramming of HCC cells.	ros	108-111	kelch like ECH associated protein 1	Homo sapiens	48-53
32253103-0	2020	Pravastatin alleviates intracellular calcium dysregulation induced by Interleukin-6 via the mitochondrial ROS pathway in adult ventricular myocytes.	ros	106-109	interleukin 6	Mus musculus	70-83
32272506-0	2020	Berberine suppresses influenza virus-triggered NLRP3 inflammasome activation in macrophages by inducing mitophagy and decreasing mitochondrial ROS.	ros	143-146	NLR family pyrin domain containing 3	Homo sapiens	47-52
32272506-5	2020	Our results demonstrate that BBR and mitochondrion-targeted superoxide dismutase mimetic (Mito-TEMPO; a specific mitochondrial ROS scavenger) significantly restricted NLRP3 inflammasome activation, increased mitochondrial membrane potential (MMP), and decreased mitochondrial ROS (mtROS) generation in J774A.1 macrophages infected with PR8 influenza virus.	ros	127-130	NLR family pyrin domain containing 3	Homo sapiens	167-172
32272506-11	2020	Taken together, these findings suggest that restricting NLRP3 inflammasome activation by decreasing ROS generation through mitophagy induction may be crucial for the BBR-mediated alleviation of influenza virus-induced inflammatory lesions.	ros	100-103	NLR family pyrin domain containing 3	Homo sapiens	56-61
32388247-6	2020	Significant reduction in ROS and inflammatory cytokine production (i.e., IL-6, IL-1beta) was observed, including a reduction in ERK1/2 phosphorylation in neutrophils stimulated with LPS and fMLP in the presence of Fbln7-C compared to untreated controls.	ros	25-28	interleukin 6	Homo sapiens	73-77
32388247-6	2020	Significant reduction in ROS and inflammatory cytokine production (i.e., IL-6, IL-1beta) was observed, including a reduction in ERK1/2 phosphorylation in neutrophils stimulated with LPS and fMLP in the presence of Fbln7-C compared to untreated controls.	ros	25-28	formyl peptide receptor 1	Homo sapiens	190-194
32463541-7	2020	Mechanistically, CBS silencing significantly elevates ROS production, thereby leading to reduced mitofusin 2 (MFN2) expression, decouple endoplasmic reticulum-mitochondria contacts, increased mitochondria fission, enhanced receptor-mediated mitophagy, and increased EC death.	ros	54-57	cystathionine beta-synthase	Homo sapiens	17-20
32413740-0	2020	Astilbin protects against cerebral ischaemia/reperfusion injury by inhibiting cellular apoptosis and ROS-NLRP3 inflammasome axis activation.	ros	101-104	NLR family, pyrin domain containing 3	Rattus norvegicus	105-110
32413740-14	2020	Astilbin also inhibited OGD-induced inflammation by suppressing ROS-NLRP3 inflammasome axis activation.	ros	64-67	NLR family, pyrin domain containing 3	Rattus norvegicus	68-73
32253103-9	2020	Pravastatin protected the cardiomyocytes against calcium disorders induced by IL-6 via the mitochondrial ROS pathway, which suggests that pravastatin may represent a promising auxiliary therapeutic strategy for cardiac injury under acute inflammation.	ros	105-108	interleukin 6	Mus musculus	78-82
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	31-34	CCAAT enhancer binding protein alpha	Homo sapiens	18-27
32438202-6	2020	RESULTS: We found ROS-NLRP3 singaling was activated in BV2 cells at OGD/R 24 h. Importantly, microglial NLRP3 activation was essential for NLRP3 activation in PC12 cells under microglial-neuronal co-culture circumstance, which has been confirmed to induced neuronal apoptosis.	ros	18-21	NLR family, pyrin domain containing 3	Rattus norvegicus	104-109
32438202-6	2020	RESULTS: We found ROS-NLRP3 singaling was activated in BV2 cells at OGD/R 24 h. Importantly, microglial NLRP3 activation was essential for NLRP3 activation in PC12 cells under microglial-neuronal co-culture circumstance, which has been confirmed to induced neuronal apoptosis.	ros	18-21	NLR family, pyrin domain containing 3	Rattus norvegicus	104-109
32361680-10	2020	Thus, abrogation of physiological ROS signaling through over-activation of Nrf2 (i.e. RS) and developing RS hampers differentiation of muscle satellite cells.	ros	34-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	31-34	NAD(P)H quinone dehydrogenase 1	Homo sapiens	99-103
32526700-7	2020	Accordingly, C/EBPbeta mediates the brain tumor growth in vivo, coupling with NQO1 and GSTP1 expression and ROS levels.	ros	108-111	CCAAT enhancer binding protein alpha	Homo sapiens	13-22
32526700-8	2020	Hence, C/EBPbeta regulates the expression of antioxidative reductases and balances the ROS, promoting brain tumor proliferation.	ros	87-90	CCAAT enhancer binding protein alpha	Homo sapiens	7-16
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	162-165	CCAAT enhancer binding protein alpha	Homo sapiens	18-27
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	162-165	NAD(P)H quinone dehydrogenase 1	Homo sapiens	99-103
32526700-6	2020	Overexpression of C/EBPbeta selectively decreases the ROS in EGFR-overexpressed U87MG cells and promotes cell proliferation via upregulating NQO1 and GSTP1; whereas knocking down C/EBPbeta elevates the ROS and reduces proliferation by repressing the reductases.	ros	54-57	CCAAT enhancer binding protein alpha	Homo sapiens	18-27
32526700-6	2020	Overexpression of C/EBPbeta selectively decreases the ROS in EGFR-overexpressed U87MG cells and promotes cell proliferation via upregulating NQO1 and GSTP1; whereas knocking down C/EBPbeta elevates the ROS and reduces proliferation by repressing the reductases.	ros	54-57	epidermal growth factor receptor	Homo sapiens	61-65
32526700-6	2020	Overexpression of C/EBPbeta selectively decreases the ROS in EGFR-overexpressed U87MG cells and promotes cell proliferation via upregulating NQO1 and GSTP1; whereas knocking down C/EBPbeta elevates the ROS and reduces proliferation by repressing the reductases.	ros	202-205	CCAAT enhancer binding protein alpha	Homo sapiens	18-27
32605179-3	2020	PEPR2, rather than PEPR1, played a predominant role in the perception of Pep1 in the roots and further triggered a strong ROS accumulation-the substance acts as an antimicrobial agent or as a secondary messenger in plant cells.	ros	122-125	PEP1 receptor 2	Arabidopsis thaliana	0-5
32605179-5	2020	Furthermore, we revealed that botrytis-induced kinase 1 (BIK1) physically interacted with PEPRs and RBOHD/F, respectively, and served downstream of the Pep1-PEPRs signaling pathway to regulate Pep1-induced ROS production and root growth inhibition.	ros	206-209	botrytis-induced kinase1	Arabidopsis thaliana	30-55
32605179-5	2020	Furthermore, we revealed that botrytis-induced kinase 1 (BIK1) physically interacted with PEPRs and RBOHD/F, respectively, and served downstream of the Pep1-PEPRs signaling pathway to regulate Pep1-induced ROS production and root growth inhibition.	ros	206-209	botrytis-induced kinase1	Arabidopsis thaliana	57-61
32432601-0	2020	Pelargonidin ameliorates CCl4-induced liver fibrosis by suppressing the ROS-NLRP3-IL-1beta axis via activating the Nrf2 pathway.	ros	72-75	NLR family pyrin domain containing 3	Homo sapiens	76-81
32576206-0	2020	Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer.	ros	14-17	signal transducer and activator of transcription 3	Homo sapiens	47-52
32576206-13	2020	CONCLUSIONS: CYT997 induces autophagy and apoptosis in gastric cancer by triggering mitochondrial ROS accumulation to silence JAK2/STAT3 pathway.	ros	98-101	signal transducer and activator of transcription 3	Homo sapiens	131-136
32587469-10	2020	PFD reduced hypoxia-induced phosphorylation of p38 through the NOX4/reactive oxygen species (ROS) signaling pathway.	ros	93-96	mitogen-activated protein kinase 14	Homo sapiens	47-50
32651830-5	2020	These findings suggest that the mechanism of resistance of strain P388/CP is associated with increased activity of glutathione metabolism that developed as a result of activation of the antioxidant response transcription factor Nrf2 against the background of high intracellular concentration of ROS.	ros	295-298	nuclear factor, erythroid derived 2, like 2	Mus musculus	228-232
32166771-11	2020	Upon 730 nm laser irradiation, MnPc@Nb-Ftn selectively killed EGFR positive A431 cells by generating ROS, whereas no obvious damage was observed on MCF-7 cells.	ros	101-104	epidermal growth factor receptor	Homo sapiens	62-66
32383848-4	2020	By the enzymatic reactions of SOD and CAT, the interior of silica nanoreactors becomes a "ROS safe zone" to protect the glucose-dependent NADH production of co-encapsulated GDH.	ros	90-93	catalase	Homo sapiens	38-41
32402583-3	2020	The purpose of this study is to test the hypothesis which states that luteolin protects against H2O2-induced oxidative stress via modulating ROS-mediated P38 MAPK/NF-kappaB and calcium-evoked mitochondrial apoptotic signalling pathways.	ros	141-144	nuclear factor kappa B subunit 1	Homo sapiens	163-172
32513988-7	2020	ANRIL could act as a molecular scaffold to promote the binding of WDR5 and HDAC3 to form WDR5 and HDAC3 complexes, they regulated target genes such as NOX1 expression by histone modification, upregulated ROS level and promote HASMC phenotype transition.	ros	204-207	WD repeat domain 5	Homo sapiens	66-70
32513988-7	2020	ANRIL could act as a molecular scaffold to promote the binding of WDR5 and HDAC3 to form WDR5 and HDAC3 complexes, they regulated target genes such as NOX1 expression by histone modification, upregulated ROS level and promote HASMC phenotype transition.	ros	204-207	WD repeat domain 5	Homo sapiens	89-93
32587470-9	2020	Immunofluorescence results revealed that ROS production in the agonist-CD137 group was higher than that in control, M5580 (a Nrf2 pathway agonist) and CAPE (a NF-kappaB pathway inhibitor) groups.	ros	41-44	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
32587470-9	2020	Immunofluorescence results revealed that ROS production in the agonist-CD137 group was higher than that in control, M5580 (a Nrf2 pathway agonist) and CAPE (a NF-kappaB pathway inhibitor) groups.	ros	41-44	nuclear factor kappa B subunit 1	Homo sapiens	159-168
32449069-5	2020	Our present review demonstrates that ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression.	ros	37-40	NFE2 like bZIP transcription factor 2	Homo sapiens	65-70
32273287-4	2020	Metabolic profiling reveals that REDD1-deficient/RAS mutant cells exhibit enhanced uptake of lysophospholipids and lipid storage, coupled to augmented fatty acid oxidation that sustains both ATP levels and ROS-detoxifying NADPH.	ros	206-209	DNA-damage-inducible transcript 4	Mus musculus	33-38
31482411-8	2020	In chronic DTHR, ROS production peaked as early as 4 h after the 5th TNCB challenge, whereas NF-kappaB activity peaked after 12 h. The increase in ROS/RNS production in acute DTHR was higher than the increase in NF-kappaB activity but the relationship was inverse in chronic DTHR.	ros	147-150	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	93-102
31482411-9	2020	Treatment with the ROS scavenger NAC had differential effects on ROS/RNS production and NF-kappaB activation during acute and chronic DTHR.	ros	19-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
32196080-6	2020	These defects were associated with both NADPH availability and ROS accumulation, suggesting that NNT serves a specific role in mitigating the oxidation of these critical protein cofactors.	ros	63-66	nicotinamide nucleotide transhydrogenase	Mus musculus	97-100
32467587-9	2020	We observed that MGO-induced autophagic cell death and inhibited the ROS-mediated Akt/mTOR signaling pathway.	ros	69-72	AKT serine/threonine kinase 1	Homo sapiens	82-85
32483169-5	2020	Using different NADPH oxidase-deficient mice, we show that TSPO is a key regulator of NOX1-dependent neurotoxic ROS production in the retina.	ros	112-115	translocator protein	Mus musculus	59-63
31987842-0	2020	Piperlongumine induces apoptosis and G2/M phase arrest in human osteosarcoma cells by regulating ROS/PI3K/Akt pathway.	ros	97-100	AKT serine/threonine kinase 1	Homo sapiens	106-109
31987842-9	2020	Furthermore, we also found that piperlongumine significantly induced apoptosis and cell cycle arrest of osteosarcoma cells by regulating ROS/PI3K/Akt signaling pathway.	ros	137-140	AKT serine/threonine kinase 1	Homo sapiens	146-149
31987842-11	2020	In addition, the underlying mechanism demonstrated that piperlongumine produced potent antitumor properties in osteosarcoma cells by regulating ROS/PI3K/Akt signaling pathway.	ros	144-147	AKT serine/threonine kinase 1	Homo sapiens	153-156
32547417-10	2020	Because higher oxidative phosphorylation can lead to higher ROS production, we tested if ROS affected the expression of AmelX and Enam genes that are essential for enamel formation.	ros	89-92	enamelin	Rattus norvegicus	130-134
32547417-11	2020	The ameloblast cell line LS8 treated with H2O2 to promote ROS elicited significant expression changes in AmelX and Enam.	ros	58-61	enamelin	Rattus norvegicus	115-119
32467587-9	2020	We observed that MGO-induced autophagic cell death and inhibited the ROS-mediated Akt/mTOR signaling pathway.	ros	69-72	mechanistic target of rapamycin kinase	Homo sapiens	86-90
32467587-11	2020	Collectively, these findings suggest that autophagy and apoptosis inhibit angiogenesis via the ROS-mediated Akt/mTOR and MAPKs signaling pathways, respectively, when HAoEC are treated with MGO.	ros	95-98	AKT serine/threonine kinase 1	Homo sapiens	108-111
32467587-11	2020	Collectively, these findings suggest that autophagy and apoptosis inhibit angiogenesis via the ROS-mediated Akt/mTOR and MAPKs signaling pathways, respectively, when HAoEC are treated with MGO.	ros	95-98	mechanistic target of rapamycin kinase	Homo sapiens	112-116
32463794-2	2020	Metformin is capable of suppressing one of the molecular triggers of the proinflammatory and prothrombotic processes of urban PM air pollution, namely the mitochondrial ROS/Ca2+ release-activated Ca2+ channels (CRAC)/IL-6 cascade.	ros	169-172	interleukin 6	Homo sapiens	217-221
32463794-3	2020	Given the linkage between mitochondrial functionality, ion channels, and inflamm-aging, the ability of metformin to target mitochondrial electron transport and prevent ROS/CRAC-mediated IL-6 release might illuminate new therapeutic avenues to quell the raging of the cytokine and thrombotic-like storms that are the leading causes of COVID-19 morbidity and mortality in older people.	ros	168-171	interleukin 6	Homo sapiens	186-190
32508682-5	2020	Taken together, our results suggest that CIH promotes the production of ROS that upregulates the level of PGC-1alpha, which may in turn inhibits the transcription of BACE1, and that a reduction in the BACE1 level may be related to CIH-induced reversible and ROS-dependent carotid body plasticity.	ros	72-75	PPARG coactivator 1 alpha	Rattus norvegicus	106-116
32508682-5	2020	Taken together, our results suggest that CIH promotes the production of ROS that upregulates the level of PGC-1alpha, which may in turn inhibits the transcription of BACE1, and that a reduction in the BACE1 level may be related to CIH-induced reversible and ROS-dependent carotid body plasticity.	ros	258-261	PPARG coactivator 1 alpha	Rattus norvegicus	106-116
32454932-8	2020	Furthermore, we found that CpG ODN enhanced phosphorylation of ERK1/2 and Akt to inhibit ROS production.	ros	89-92	thymoma viral proto-oncogene 1	Mus musculus	74-77
32433492-8	2020	Our findings indicate that lactate preconditioning primes fibroblasts to switch from OXPHOS to glycolysis metabolism, in part, through ROS-mediated HIF-1alpha stabilization.	ros	135-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	148-158
32427102-8	2020	This results in reduced SOD2 expression causing an increase of ROS and mitochondrial dysfunction.	ros	63-66	superoxide dismutase 2, mitochondrial	Danio rerio	24-28
32509151-0	2020	Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2.	ros	21-24	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
32509171-10	2020	In addition, it was demonstrated that Cav-1 promoted ROS generation via the activation of Rac1-dependent NADPH oxidase (NOX).	ros	53-56	caveolin 1	Rattus norvegicus	38-43
32509141-5	2020	Mechanistically, we showed that apatinib suppressed glutathione to generate ROS via the downregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and maintained an antitumor effect at a low level of VEGFR2 in ovarian cancer, suggesting that combination of apatinib with Nrf2 inhibitor may be a promising therapy strategy for patients with ovarian cancer.	ros	76-79	NFE2 like bZIP transcription factor 2	Homo sapiens	155-159
32536929-9	2020	Additionally, Systemin treated plants display enhanced BAK1 and BIK1 gene expression following infection as well as increased production of ROS after PAMP treatment suggesting that Systemin sensitizes Arabidopsis perception to pathogens and PAMPs.	ros	140-143	systemin	Solanum lycopersicum	14-22
32397184-6	2020	The in vitro results demonstrated that (i) the three ligands are highly cytotoxic for MRP1-expressing cells; (ii) their effect is MRP1-mediated; (iii) they increase the cytotoxicity induced by cis-Pt, the therapeutic agent commonly used in the treatment of lung tumors; and (iv) their effect is ROS-mediated.	ros	295-298	ATP binding cassette subfamily C member 1	Homo sapiens	86-90
32397184-6	2020	The in vitro results demonstrated that (i) the three ligands are highly cytotoxic for MRP1-expressing cells; (ii) their effect is MRP1-mediated; (iii) they increase the cytotoxicity induced by cis-Pt, the therapeutic agent commonly used in the treatment of lung tumors; and (iv) their effect is ROS-mediated.	ros	295-298	ATP binding cassette subfamily C member 1	Homo sapiens	130-134
32536929-9	2020	Additionally, Systemin treated plants display enhanced BAK1 and BIK1 gene expression following infection as well as increased production of ROS after PAMP treatment suggesting that Systemin sensitizes Arabidopsis perception to pathogens and PAMPs.	ros	140-143	systemin	Solanum lycopersicum	181-189
32454852-2	2020	Macrophages are equipped with antioxidant mechanisms to cope with intracellular ROS produced during immune response, and Nrf2 (NF-E2-related factor 2)/HO-1 (heme oxygenase-1) pathway is an attractive target due to its protective effect against ROS-induced cell damage in inflamed macrophages.	ros	80-83	heme oxygenase 1	Mus musculus	151-155
32386538-0	2020	A Twist between ROS and Sperm-Mediated Intergenerational Epigenetic Inheritance.	ros	16-19	twist family bHLH transcription factor 1	Homo sapiens	2-7
32670550-0	2020	beta-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1alpha/TGF-beta/MMPs in A549 cells.	ros	101-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	115-125
32454852-2	2020	Macrophages are equipped with antioxidant mechanisms to cope with intracellular ROS produced during immune response, and Nrf2 (NF-E2-related factor 2)/HO-1 (heme oxygenase-1) pathway is an attractive target due to its protective effect against ROS-induced cell damage in inflamed macrophages.	ros	244-247	nuclear factor, erythroid derived 2, like 2	Mus musculus	121-125
32454852-2	2020	Macrophages are equipped with antioxidant mechanisms to cope with intracellular ROS produced during immune response, and Nrf2 (NF-E2-related factor 2)/HO-1 (heme oxygenase-1) pathway is an attractive target due to its protective effect against ROS-induced cell damage in inflamed macrophages.	ros	244-247	heme oxygenase 1	Mus musculus	151-155
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	ros	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
32269896-7	2020	The extract reduced ROS in these cells, which consequently decreased the degree of autophagic cell death by restoring expressions of mTOR, survivin and BECN1 to their respective normal levels.	ros	20-23	mechanistic target of rapamycin kinase	Homo sapiens	133-137
32509390-5	2020	A proteomic profiling of cancer cell lines revealed that NQO1 abundance is negatively correlated with IC50; in vitro assays showed that NAPA is a substrate for NQO1, which mediates the generation of ROS that leads to cell death.	ros	199-202	NAD(P)H quinone dehydrogenase 1	Homo sapiens	57-61
32509390-5	2020	A proteomic profiling of cancer cell lines revealed that NQO1 abundance is negatively correlated with IC50; in vitro assays showed that NAPA is a substrate for NQO1, which mediates the generation of ROS that leads to cell death.	ros	199-202	NAD(P)H quinone dehydrogenase 1	Homo sapiens	160-164
32141651-3	2020	The previous studies have confirmed that Immp2l mutant mice (Immp2lTg(Tyr)979Ove or Immp2l-/- ) suffered from increased levels of oxidative stress(OS) and male infertility, heterozygous lmmp2l mice (Immp2l+/- ) showed no altered ROS levels under physiological condition.	ros	229-232	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	Mus musculus	41-47
32141651-3	2020	The previous studies have confirmed that Immp2l mutant mice (Immp2lTg(Tyr)979Ove or Immp2l-/- ) suffered from increased levels of oxidative stress(OS) and male infertility, heterozygous lmmp2l mice (Immp2l+/- ) showed no altered ROS levels under physiological condition.	ros	229-232	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	Mus musculus	61-67
32141651-3	2020	The previous studies have confirmed that Immp2l mutant mice (Immp2lTg(Tyr)979Ove or Immp2l-/- ) suffered from increased levels of oxidative stress(OS) and male infertility, heterozygous lmmp2l mice (Immp2l+/- ) showed no altered ROS levels under physiological condition.	ros	229-232	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	Mus musculus	61-67
32370057-0	2020	Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4.	ros	71-74	TNF superfamily member 10	Homo sapiens	43-48
32370057-0	2020	Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4.	ros	71-74	mitogen-activated protein kinase 8	Homo sapiens	98-101
32370057-0	2020	Curcumin Sensitizes Kidney Cancer Cells to TRAIL-Induced Apoptosis via ROS Mediated Activation of JNK-CHOP Pathway and Upregulation of DR4.	ros	71-74	DNA damage inducible transcript 3	Homo sapiens	102-106
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	ros	39-42	NAD(P)H quinone dehydrogenase 1	Homo sapiens	58-63
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	ros	39-42	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
32146648-6	2020	Corroborating the above observations, we found that the ROS scavenger N-acetylcysteine (NAC) countered caspase-3 activity and the cells were rescued from apoptosis.	ros	56-59	caspase 3	Homo sapiens	103-112
32236964-9	2020	beta-CYP might achieve these effects through downregulating the secretion of TNF-alpha via elevating ROS levels in RAW 264.7 cells.	ros	101-104	tumor necrosis factor	Mus musculus	77-86
32495853-10	2020	In addition, MT1M siRNA decreased SOD activity, increased ROS content and reduced PI3K/AKT protein phosphorylation.	ros	58-61	metallothionein 1M	Homo sapiens	13-17
32247459-0	2020	Oleic acid and hydroxytyrosol present in olive oil promote ROS and inflammatory response in normal cultures of murine dermal fibroblasts through the NF-kappaB and NRF2 pathways.	ros	59-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167
32360463-1	2020	Superoxide dismutase (SOD) is an important member of the antioxidant defense system and is proposed as a therapeutic agent against the ROS-mediated diseases, and a therapeutic target for cancer treatment.	ros	135-138	superoxide dismutase 1	Homo sapiens	0-20
32171165-9	2020	Taken together, our results suggest that EGCG functioned to maintain a delicate balance between ROS signaling and ROS scavenging via RBOH1, which enhanced tomato resistance to TMV.	ros	114-117	NADPH oxidase	Solanum lycopersicum	133-138
32360463-1	2020	Superoxide dismutase (SOD) is an important member of the antioxidant defense system and is proposed as a therapeutic agent against the ROS-mediated diseases, and a therapeutic target for cancer treatment.	ros	135-138	superoxide dismutase 1	Homo sapiens	22-25
32382571-5	2020	And the expression of ROS, cytokines, adhesion molecules, and arachidonic acid was measured when THP-1 and HUVECs were stimulated by NP-activated complement.	ros	22-25	GLI family zinc finger 2	Homo sapiens	97-102
32411168-7	2020	Moreover, Arabidopsis mutant analysis demonstrated that three ROS and redox homeostatasis related DEGs of identified DEM-DEG pairs, GSTU2, GSTU5, and RBOHF contributed to the AGO2-mediated defense against S. sclerotiorum.	ros	62-65	glutathione S-transferase tau 5	Arabidopsis thaliana	139-144
32411168-7	2020	Moreover, Arabidopsis mutant analysis demonstrated that three ROS and redox homeostatasis related DEGs of identified DEM-DEG pairs, GSTU2, GSTU5, and RBOHF contributed to the AGO2-mediated defense against S. sclerotiorum.	ros	62-65	Argonaute family protein	Arabidopsis thaliana	175-179
32083866-8	2020	Diosmin reduced LPS-induced total ROS production (DCFDA assay) and superoxide anion production (NBT assay and NBT-positive cells).	ros	34-37	toll-like receptor 4	Mus musculus	16-19
32300208-9	2020	Pharmacological targeting of ROS- and ERK1/2 signalling pathways prevented CSE-induced senescence of CCR6+Th17 lymphocytes as well as VEGFalpha secretion.	ros	29-32	vascular endothelial growth factor A	Homo sapiens	134-143
32326366-1	2020	(+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma.	ros	23-26	NFE2 like bZIP transcription factor 2	Homo sapiens	110-114
32318242-8	2020	Moreover, double deletion of ISC1 and PKH1 has a drastic effect on cell survival associated with increased ROS accumulation and release of cytochrome c, which is counteracted by overexpression of the PKA pathway negative regulator PDE2.	ros	107-110	3',5'-cyclic-nucleotide phosphodiesterase PDE2	Saccharomyces cerevisiae S288C	231-235
32377291-9	2020	In addition, overexpression of Nrf2 reversed the effects of Cav-1 knockdown on PSCs, increasing ROS production and enhancing paracrine shh/MMP2/bFGF/IL-6 signaling.	ros	96-99	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
32377291-9	2020	In addition, overexpression of Nrf2 reversed the effects of Cav-1 knockdown on PSCs, increasing ROS production and enhancing paracrine shh/MMP2/bFGF/IL-6 signaling.	ros	96-99	caveolin 1	Homo sapiens	60-65
32398959-4	2020	Septin4-overexpressing colon cancer cells displayed augmented apoptotic cell death and ROS production.	ros	87-90	septin 4	Homo sapiens	0-7
32398959-5	2020	Additionally, Septin4-knockdown cells revealed a resistance of DOX-induced cell death and reduced ROS production.	ros	98-101	septin 4	Homo sapiens	14-21
32251485-11	2020	In conclusions, eNOS and ET-1 significantly down-regulated in co-culture with stimulated X-CGD neutrophils through their excessive NO and the lack of ROS production.	ros	150-153	nitric oxide synthase 3	Homo sapiens	16-20
32251485-12	2020	These findings suggest that ROS generated from neutrophils may mediate arterial tone affecting eNOS and ET-1 expression via their NO and ROS production.	ros	28-31	nitric oxide synthase 3	Homo sapiens	95-99
32251485-12	2020	These findings suggest that ROS generated from neutrophils may mediate arterial tone affecting eNOS and ET-1 expression via their NO and ROS production.	ros	28-31	endothelin 1	Homo sapiens	104-108
32251485-12	2020	These findings suggest that ROS generated from neutrophils may mediate arterial tone affecting eNOS and ET-1 expression via their NO and ROS production.	ros	137-140	nitric oxide synthase 3	Homo sapiens	95-99
32251485-12	2020	These findings suggest that ROS generated from neutrophils may mediate arterial tone affecting eNOS and ET-1 expression via their NO and ROS production.	ros	137-140	endothelin 1	Homo sapiens	104-108
32334473-9	2020	BHNKA induced necroptosis by activation of the RIP1-RIP3-MLKL necroptosis cascade, up-regulation of cyclophilin D (CypD) protein expression to stimulate ROS generation.	ros	153-156	peptidylprolyl isomerase F	Homo sapiens	115-119
31030314-5	2020	One compound produces ROS which results in breast (MCF7) cancer cell death caused by apoptosis as evidenced by caspase 3/7 activation.	ros	22-25	caspase 3	Homo sapiens	111-120
32319560-10	2020	BEA and CEA exerted various effects, including inducing apoptotic cell death, reducing mitochondrial transmembrane potential, increasing the levels of intracellular ROS, activating caspases, upregulating pro-apoptotic and downregulating anti-apoptotic genes and proteins.	ros	165-168	CEA cell adhesion molecule 3	Homo sapiens	8-11
32231125-5	2020	The GST activity of the knockout Atgstu24 mutant was even higher under control conditions compared to the Col-0 plants, while the ROS level and its vitality did not differ significantly from the wild-type.	ros	130-133	glutathione S-transferase TAU 24	Arabidopsis thaliana	33-41
32323835-9	2020	Mechanistic exploration demonstrated that the tumor-suppressive effect of MiD49 was mediated by decreased mitochondrial fission and subsequent reduced ROS production in PC cells.	ros	151-154	mitochondrial elongation factor 2	Homo sapiens	74-79
32328491-3	2020	However, pathways triggering NLRP3 activation, such as potassium efflux, ROS production or lysosomal permeabilization, can be required or not, depending on the activators used.	ros	73-76	NLR family pyrin domain containing 3	Homo sapiens	29-34
32057231-4	2020	Ultrasmall (4.5 nm) Au nanoparticles (Au4.5) activate the NLRP3 inflammasome through directly penetrating into cell cytoplasm to promote robust ROS production and target autophagy protein-LC3 (microtubule-associated protein 1-light chain 3) for proteasomal degradation in an endocytic/phagocytic-independent manner.	ros	144-147	NLR family pyrin domain containing 3	Homo sapiens	58-63
32107506-8	2020	The PVP-PdNPs generate continuous ROS in the mitochondria; this leads to the damage of the mitochondrial membrane potential and nuclear DNA and induces apoptosis through caspase3/7 enzymatic activity.	ros	34-37	caspase 3	Homo sapiens	170-178
32256964-9	2020	In addition, autophagy inhibitors or NAC could counteract the effect of DpdtC and restore the level of p53 to the control group, indicating that the upregulation of p53 was caused by ferritinophagy-mediated ROS production.	ros	207-210	tumor protein p53	Homo sapiens	103-106
32256964-9	2020	In addition, autophagy inhibitors or NAC could counteract the effect of DpdtC and restore the level of p53 to the control group, indicating that the upregulation of p53 was caused by ferritinophagy-mediated ROS production.	ros	207-210	tumor protein p53	Homo sapiens	165-168
32256964-10	2020	In conclusion, our data demonstrated that the inhibition of EMT induced by DpdtC was realized through ferritinophagy-mediated ROS/p53 pathway, which supported that the activation of ferritinophagic flux was the main driving force in EMT inhibition in gastric cancer cells, and further strengthening the concept that NCOA4 participates in EMT process.	ros	126-129	tumor protein p53	Homo sapiens	130-133
32157127-4	2020	Specifically, after downregulation of the complex I subunit ND-49 (mammalian NDUFS2), TOR activates JNK to induce cell death and ROS production essential for the stimulation of compensatory apoptosis-induced proliferation within the tissue.	ros	129-132	NADH:ubiquinone oxidoreductase core subunit S2	Homo sapiens	77-83
32157127-4	2020	Specifically, after downregulation of the complex I subunit ND-49 (mammalian NDUFS2), TOR activates JNK to induce cell death and ROS production essential for the stimulation of compensatory apoptosis-induced proliferation within the tissue.	ros	129-132	RAR related orphan receptor C	Homo sapiens	86-89
32157127-4	2020	Specifically, after downregulation of the complex I subunit ND-49 (mammalian NDUFS2), TOR activates JNK to induce cell death and ROS production essential for the stimulation of compensatory apoptosis-induced proliferation within the tissue.	ros	129-132	mitogen-activated protein kinase 8	Homo sapiens	100-103
32151068-5	2020	CN inhibited the phosphorylation of c-Src and PKC mediated by intracellular ROS responsible for the distinctive activation of the MAPKs in rVvhA-treated HT-29 cells.	ros	76-79	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-41
32152280-5	2020	RNF113A deficiency triggers cell death upon DNA damage through multiple mechanisms, including apoptosis via the destabilization of the prosurvival protein MCL-1, ferroptosis due to enhanced SAT1 expression, and increased production of ROS due to altered Noxa1 expression.	ros	235-238	ring finger protein 113A	Homo sapiens	0-7
32210950-5	2020	Further reduced iCa2+ flux induced ROS which lead to IFN-gamma reduction and increased IL-10 producing T suppressors through the STAT3-STAT5 axis.	ros	35-38	interferon gamma	Mus musculus	53-62
32210950-5	2020	Further reduced iCa2+ flux induced ROS which lead to IFN-gamma reduction and increased IL-10 producing T suppressors through the STAT3-STAT5 axis.	ros	35-38	interleukin 10	Mus musculus	87-92
32210950-5	2020	Further reduced iCa2+ flux induced ROS which lead to IFN-gamma reduction and increased IL-10 producing T suppressors through the STAT3-STAT5 axis.	ros	35-38	signal transducer and activator of transcription 3	Homo sapiens	129-134
32170186-7	2020	The changes in DL intensity and kinetics highlighted a possible effect of nanoparticle matrix on mitochondria, through the involvement of the NADH pool and ROS production that, in turn, activates ERK1/2 pathways.	ros	156-159	mitogen-activated protein kinase 3	Homo sapiens	196-202
32092796-12	2020	These results indicated that increased miR-34c mediated synaptic and memory deficits by targeting SYT1 through ROS-JNK-p53 pathway and the miR-34c/SYT1 pathway could be considered as a promising novel therapeutic target for patients with AD.	ros	111-114	mitogen-activated protein kinase 8	Homo sapiens	115-118
32092796-12	2020	These results indicated that increased miR-34c mediated synaptic and memory deficits by targeting SYT1 through ROS-JNK-p53 pathway and the miR-34c/SYT1 pathway could be considered as a promising novel therapeutic target for patients with AD.	ros	111-114	tumor protein p53	Homo sapiens	119-122
31367013-4	2020	Knockout of SLC27A5 increases polyunsaturated lipids, leading to increased NADP+/NADPH ratio, ROS production as well as lipid peroxidation and the subsequent accumulation of 4-hydroxy-2-nonenal (4-HNE) in hepatoma cells.	ros	94-97	solute carrier family 27 member 5	Homo sapiens	12-19
32121588-1	2020	Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRalpha/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs).	ros	98-101	AKT serine/threonine kinase 1	Homo sapiens	128-131
32121588-1	2020	Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRalpha/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs).	ros	98-101	NFE2 like bZIP transcription factor 2	Homo sapiens	132-136
31392350-6	2020	Thus, the simultaneous depletion of glutathione and destabilization of mitochondria by ROS can compromise the barrier properties of the mitochondrial membrane, leading to cytochrome c release and the activation of the mitochondrial apoptotic pathway.	ros	87-90	cytochrome c, somatic	Homo sapiens	171-183
31629709-6	2020	Moreover, schisantherin A induced ROS-dependent JNK phosphorylation with higher ROS production.	ros	34-37	mitogen-activated protein kinase 8	Homo sapiens	48-51
31241142-11	2020	Mechanistically, TXNIP suppressed autophagosome clearance via increasing ROS level.	ros	73-76	thioredoxin interacting protein	Mus musculus	17-22
31992853-2	2020	The goal of this study was to determine how PIM kinases impact mitochondrial dynamics, ROS production, and response to chemotherapy in lung cancer.	ros	87-90	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	44-47
31465746-6	2020	Moreover, SOD3 suppressed LL-37-induced expression of inflammatory mediators, ROS production and p38/ERK activation in mast cells.	ros	78-81	cathelicidin antimicrobial peptide	Homo sapiens	26-31
31992853-4	2020	Inhibition of PIM kinases caused excessive mitochondrial fission and significant upregulation of mitochondrial superoxide, increasing intracellular ROS.	ros	148-151	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	14-17
32106859-6	2020	RESULTS: Here, we provide clinical evidence to show that arachidonate lipoxygenase 15 (ALOX15) is closely related with lipid-ROS production in gastric cancer, and that exosome-miR-522 serves as a potential inhibitor of ALOX15.	ros	125-128	arachidonate 15-lipoxygenase	Homo sapiens	87-93
32100973-4	2020	We previously found that in Saccharomyces cerevisiae, two mutations in ATP synthase subunit a (atp6-P163S and atp6-K90E, equivalent to those detected in prostate and thyroid cancer samples, respectively) in the OM45-GFP background affected ROS and calcium homeostasis and delayed yeast PTP (yPTP) induction upon calcium treatment by modulating the dynamics of ATP synthase dimer/oligomer formation.	ros	240-243	Om45p	Saccharomyces cerevisiae S288C	211-215
32214279-10	2020	Two apoptotic waves were observed at 12-24 h and at 72 h. The increase of ROS production, at 24 h until the end of the culture period, was accompanied by the induction, at 48 h, of redox-related Cat, Sod1, Sod2, Gpx1 and Gpx4 genes.	ros	74-77	superoxide dismutase 1, soluble	Mus musculus	200-204
32181166-7	2020	Excessive ROS will activate nuclear factor erythroid 2-like 2 (Nrf2).	ros	10-13	NFE2 like bZIP transcription factor 2	Homo sapiens	28-61
32181166-7	2020	Excessive ROS will activate nuclear factor erythroid 2-like 2 (Nrf2).	ros	10-13	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
32181166-8	2020	Nrf2 will bind to antioxidant response elements, to protect multi organs against ROS, including this brain injury.	ros	81-84	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
32121012-11	2020	We suggest that the antitumor effect of A. hirsuta extract is achieved by apoptosis promotion and cell cycle arrest mediated by the activation of JNK and p38 signaling pathway via ROS generation.	ros	180-183	mitogen-activated protein kinase 8	Homo sapiens	146-149
32121012-11	2020	We suggest that the antitumor effect of A. hirsuta extract is achieved by apoptosis promotion and cell cycle arrest mediated by the activation of JNK and p38 signaling pathway via ROS generation.	ros	180-183	mitogen-activated protein kinase 14	Homo sapiens	154-157
32214279-10	2020	Two apoptotic waves were observed at 12-24 h and at 72 h. The increase of ROS production, at 24 h until the end of the culture period, was accompanied by the induction, at 48 h, of redox-related Cat, Sod1, Sod2, Gpx1 and Gpx4 genes.	ros	74-77	superoxide dismutase 2, mitochondrial	Mus musculus	206-210
32296583-12	2020	Subsequently, IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3K/AKT/ROS axis in TINs.	ros	96-99	C-X-C motif chemokine ligand 8	Homo sapiens	14-18
32024182-8	2020	The relative oxygen species (ROS) significantly increased in cells with inhibited PTP4A3, while the rise was inferior to the control cells at the 20 muM 1,4-BQ group.	ros	29-32	protein tyrosine phosphatase 4A3	Homo sapiens	82-88
32104690-9	2020	Fascinatingly, among the differentially expressed mRNAs, PFK1 was one of the most upregulated genes, which was involved in the glycolysis process and ROS generation.	ros	150-153	6-phosphofructokinase subunit alpha	Saccharomyces cerevisiae S288C	57-61
31811910-5	2020	Thioredoxin reductase 1 (TR1), a pivotal target gene of Nrf2, was observed to promote 5-FU resistance by reducing intracellular ROS levels.	ros	128-131	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
31464976-7	2020	Mechanistically, LY treatment elevated ROS generation that activates the p38 mitogen-activated protein kinases (MAPKs) and p53-dependent apoptotic program.	ros	39-42	mitogen-activated protein kinase 14	Homo sapiens	73-76
31464976-7	2020	Mechanistically, LY treatment elevated ROS generation that activates the p38 mitogen-activated protein kinases (MAPKs) and p53-dependent apoptotic program.	ros	39-42	tumor protein p53	Homo sapiens	123-126
31464976-8	2020	Inhibition of ROS generation by NAC or p38 MAPK signaling by SB203580 attenuated the p53-mediated cell cycle arrest and apoptosis induced by LY.	ros	14-17	tumor protein p53	Homo sapiens	85-88
32698747-10	2020	We further demonstrated that apoptosis induction in HL-60 cells was mediated by increasing intracellular ROS levels via ERK but not p38 MAPKs pathway.	ros	105-108	mitogen-activated protein kinase 1	Homo sapiens	120-123
31706245-11	2020	Our study proved that COFs-derived PM2.5 could damage the tubule formation of HUVECs in vitro, which could be effectively rescue by co-incubation with VD3, in which processes the ROS/NLRP3/VEGF signaling pathway played a crucial role.	ros	179-182	NLR family pyrin domain containing 3	Homo sapiens	183-188
31706245-11	2020	Our study proved that COFs-derived PM2.5 could damage the tubule formation of HUVECs in vitro, which could be effectively rescue by co-incubation with VD3, in which processes the ROS/NLRP3/VEGF signaling pathway played a crucial role.	ros	179-182	vascular endothelial growth factor A	Homo sapiens	189-193
32047580-8	2020	Cynaroside inhibited IL-1beta-induced expression of catabolic factors (nitrite, iNOS, ROS, PGE2, Cox-2, MMP-1, MMP-3, MMP-13, and ADAMTS-4) and degradation of anabolic factors (collagen type II and aggrecan).	ros	86-89	interleukin 1 alpha	Rattus norvegicus	21-29
31954373-0	2020	Activated Drp1-mediated mitochondrial ROS influence the gut microbiome and intestinal barrier after hemorrhagic shock.	ros	38-41	dynamin 1-like	Mus musculus	10-14
31954373-6	2020	Together, these data suggest that Drp1 activation perturbs the gut microbiome community and SCFA production in a ROS-specific manner and thereby substantially disturbs tight junctions and intestinal barrier function after hemorrhagic shock.	ros	113-116	dynamin 1-like	Mus musculus	34-38
31825438-7	2020	Meanwhile, FSGHF3 and peptide treatment promotes antioxidant enzyme expression via activating Nrf2, which results in the removal of ROS and inhibition of NF-kappaB activation.	ros	132-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	94-98
31968693-6	2020	Although the precise mechanism of the effect is still unknown to us, we know that the molecule is a PARP inhibitor, chaperone co-inducer, reduces ROS production, and is able to remodel the organization of cholesterol-rich membrane domains.	ros	146-149	poly(ADP-ribose) polymerase 1	Homo sapiens	100-104
32329644-10	2020	Activation of ERK1/2-p38 MAPKs and production of intracellular ROS has been observed over Naringin treatment.	ros	63-66	mitogen-activated protein kinase 3	Homo sapiens	14-20
32329644-11	2020	It has also been elucidated that pre-treatment with NAC inhibited mitochondria-LC3B colocalization, where ROS acted as upstream of ERK1/2-p38 MAPKs activation.	ros	106-109	mitogen-activated protein kinase 3	Homo sapiens	131-137
31648639-7	2020	Furthermore, Ag@PTX enhanced the anti-canceractivity of A549 cells through ROS-mediated p53 and AKT signalling pathways.	ros	75-78	tumor protein p53	Homo sapiens	88-91
31819175-0	2020	Aconitase 2 inhibits the proliferation of MCF-7 cells promoting mitochondrial oxidative metabolism and ROS/FoxO1-mediated autophagic response.	ros	103-106	aconitase 2	Homo sapiens	0-11
31819175-8	2020	We also demonstrated that the enhancement of oxidative metabolism was supported by mitochondrial biogenesis and FoxO1-mediated autophagy/mitophagy that sustains the increased ROS burst.	ros	175-178	forkhead box O1	Homo sapiens	112-117
31755616-12	2020	However, TIM-4 interference in the KCs inhibited Akt1-mediated ROS production, resulting in the suppression of PINK1, Parkin and LC3-II/I activation and the reduction of TGF-beta1 secretion during liver fibrosis.	ros	63-66	T cell immunoglobulin and mucin domain containing 4	Mus musculus	9-14
31755616-12	2020	However, TIM-4 interference in the KCs inhibited Akt1-mediated ROS production, resulting in the suppression of PINK1, Parkin and LC3-II/I activation and the reduction of TGF-beta1 secretion during liver fibrosis.	ros	63-66	thymoma viral proto-oncogene 1	Mus musculus	49-53
31648639-7	2020	Furthermore, Ag@PTX enhanced the anti-canceractivity of A549 cells through ROS-mediated p53 and AKT signalling pathways.	ros	75-78	AKT serine/threonine kinase 1	Homo sapiens	96-99
32147640-6	2020	The in vitro experiments further showed that MECP2 overexpression significantly attenuated CSE-triggered cell growth attenuation, cell cycle arrest, apoptosis and ROS generation in lung epithelial cells by CCK-8 and flow cytometry assays.	ros	163-166	methyl-CpG binding protein 2	Homo sapiens	45-50
32954380-15	2020	The expression of antioxidant enzymes, SOD1, was reduced in HHT1 MNCs, which was accompanied with an increase of ROS in HHT MNCs and nitric oxide in HHT1 plasma.	ros	113-116	superoxide dismutase 1	Homo sapiens	39-43
31250150-7	2020	Mitochondrial malfunction activates ROS signaling, which triggers caspase-3-mediated apoptosis of parietal cells.	ros	36-39	caspase 3	Homo sapiens	66-75
31751569-13	2020	Mitochondrial ROS were increased by Trx2 deletion and importantly, mitochondria-specific ROS scavenger MitoTEMPO suppressed HDAC4 elevation, HCN4 reduction, and sinus bradycardia in Trx2ccsKO mice.	ros	14-17	histone deacetylase 4	Mus musculus	124-129
31751569-13	2020	Mitochondrial ROS were increased by Trx2 deletion and importantly, mitochondria-specific ROS scavenger MitoTEMPO suppressed HDAC4 elevation, HCN4 reduction, and sinus bradycardia in Trx2ccsKO mice.	ros	89-92	histone deacetylase 4	Mus musculus	124-129
31751569-13	2020	Mitochondrial ROS were increased by Trx2 deletion and importantly, mitochondria-specific ROS scavenger MitoTEMPO suppressed HDAC4 elevation, HCN4 reduction, and sinus bradycardia in Trx2ccsKO mice.	ros	89-92	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	141-145
31751569-15	2020	Loss of Trx2 reduces HCN4 expression via a mitochondrial ROS-HDAC4-MEF2C pathway and subsequently induces sick sinus syndrome in mice.	ros	57-60	hyperpolarization-activated, cyclic nucleotide-gated K+ 4	Mus musculus	21-25
31751569-15	2020	Loss of Trx2 reduces HCN4 expression via a mitochondrial ROS-HDAC4-MEF2C pathway and subsequently induces sick sinus syndrome in mice.	ros	57-60	histone deacetylase 4	Mus musculus	61-66
31914665-4	2020	As in human ALS, expression of mutant dog SOD1 was associated with statistically significant increased aggregate formation, raised superoxide levels (ROS), and altered mitochondrial morphology (increased branching (form factor)), when compared to wild-type dog SOD1-expressing cells.	ros	150-153	superoxide dismutase 1	Canis lupus familiaris	42-46
30262241-0	2020	Corrigendum to "CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression" [Redox Biol.	ros	143-146	angiotensinogen	Homo sapiens	56-70
31792650-9	2020	CST attenuated the immediate generation of ROS and the increase in glutathione peroxidase activity induced by norepinephrine treatment.	ros	43-46	chromogranin A	Homo sapiens	0-3
30262241-0	2020	Corrigendum to "CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression" [Redox Biol.	ros	143-146	interleukin 6	Homo sapiens	147-151
31885807-3	2019	Under oxidative stress, stromal cell differentiation was impaired, but this impairment was abrogated by rHB-EGF accompanied with the reduced levels of ROS and MDA which were regarded as the biomarkers for oxidative stress, indicating an antioxidant role of HB-EGF.	ros	151-154	heparin-binding EGF-like growth factor	Rattus norvegicus	104-111
32158153-10	2020	Evidence of this relation manifested in the elevation in MDA and SOD levels and reduction in GPx and CAT levels as a consequence to the release of ROS resulting from Demodex infection.	ros	147-150	catalase	Canis lupus familiaris	101-104
31949875-4	2019	Here, we showed mitochondrial dysfunction, elevated ROS level, impaired antioxidant enzymes, and loss of FOXO1/3 in autophagy deficiency cellular models established by either chemical inhibitors or knocking down/out key molecules implementing autophagy, and overexpression of FOXO1/3 restored antioxidant enzymes hence suppressed elevated ROS; knockdown of p62 increased protein level of FOXO1/3 and recovered FOXO1 in Atg5-knockdown cells.	ros	339-342	forkhead box O1	Homo sapiens	105-110
31949875-5	2019	Our data demonstrates that the loss of FOXO1/3 is responsible for the impairment of antioxidant enzymes and the consequent elevation of ROS, and accumulation of p62 under condition of autophagy deficiency might be mediating the loss of FOXO1/3.	ros	136-139	forkhead box O1	Homo sapiens	39-46
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	ros	34-37	caspase 1	Homo sapiens	99-108
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	ros	34-37	NPHS2 stomatin family member, podocin	Homo sapiens	140-147
31363875-3	2019	Growth inhibition of cells overexpressing FSH1 is due to induction of cell death associated with cell death markers typical of mammalian apoptosis namely DNA fragmentation, phosphatidylserine externalization, ROS accumulation, Cytochrome c release, and altered mitochondrial membrane potential.	ros	209-212	putative serine hydrolase	Saccharomyces cerevisiae S288C	42-46
31454517-11	2019	Upregulation of Miro1 in the combination group increased mitochondrial transfer and lead to a greater increase in neuronal cell viability and ATP, as well as a decrease in ROS.	ros	172-175	ras homolog family member T1	Homo sapiens	16-21
31470141-0	2019	Reversine inhibits MMP-3, IL-6 and IL-8 expression through suppression of ROS and JNK/AP-1 activation in interleukin-1beta-stimulated human gingival fibroblasts.	ros	74-77	interleukin 1 beta	Homo sapiens	105-122
31470141-10	2019	CONCLUSION: Reversine inhibits IL-1beta-induced MMP and cytokine expression via inhibition of MAPK/AP-1 activation and ROS generation.	ros	119-122	interleukin 1 beta	Homo sapiens	31-39
31722779-4	2019	Transduced Tat-CIAPIN1 significantly reduced ROS production and DNA fragmentation in LPS-exposed Raw 264.7 cells.	ros	45-48	cytokine induced apoptosis inhibitor 1	Mus musculus	15-22
31147869-7	2019	In contrast, AbetaO stimulation caused increases in both ROS and ER stress that were notably higher in HT-22 cells with silenced Prx4 expression than in HT-22 cells.	ros	57-60	peroxiredoxin 4	Mus musculus	129-133
31511637-0	2019	Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	ros	72-75	mitogen-activated protein kinase 1	Homo sapiens	24-27
31511637-0	2019	Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	ros	72-75	interleukin 1 beta	Homo sapiens	91-99
31237149-9	2019	Furthermore, ROS and western blot assay suggest that GNPs-pD-PTX-PLGA-Ms with NIR showed more ROS generation, followed by downregulation of the expression levels of antioxidant enzyme (SOD2 and CATALASE).	ros	94-97	catalase	Homo sapiens	194-202
31494226-6	2019	Moreover, CXCR2-mediated increases in the recruitment of Mac-2-positive macrophages, proinflammatory cytokines, vascular permeability and ROS production in SHR hearts were markedly attenuated by SB225002.	ros	138-141	C-X-C motif chemokine receptor 2	Rattus norvegicus	10-15
31539718-8	2019	The underlying mechanism was related to the activation of the Nrf2/Ho-1 signaling pathway, which subsequently suppressed intracellular reactive oxidative species (ROS) production and malondialdehyde (MDA) and NADPH oxidase (Nox) activity, and to the restoration of Sod and Gsh-px activation.	ros	163-166	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
31546196-7	2019	These results provide support for the suggestion that multi-targeting approach involving the interaction with cyclooxygenase-1/2 and the redox enzymes that increases ROS production, enhances cell death in vitro.	ros	166-169	prostaglandin-endoperoxide synthase 1	Homo sapiens	110-128
30810431-5	2019	S-1 induced significant reduction of cell viability, caused apoptosis, and up-regulated ROS production.	ros	88-91	proteasome 26S subunit, non-ATPase 1	Homo sapiens	0-3
31511364-8	2019	Significantly, connexin-43 expression increased in HC aortic tissues, possibly allowing ROS movement into the endothelium and reduction of eNOS activity.	ros	88-91	gap junction protein, alpha 1	Rattus norvegicus	15-26
31585128-5	2019	TUBA4A ubiquitination and glutathionylation were also observed, possibly due to a selenium-dependent increase of ROS, leading to perturbation and degradation of MTs.	ros	113-116	tubulin alpha 4a	Homo sapiens	0-6
31558316-0	2019	Ipatasertib sensitizes colon cancer cells to TRAIL-induced apoptosis through ROS-mediated caspase activation.	ros	77-80	TNF superfamily member 10	Homo sapiens	45-50
31558316-5	2019	Excessive cellular levels of ROS further induced DNA damage and subsequently activated apoptotic signaling pathways in TRAIL-resistant HT-29 cells.	ros	29-32	TNF superfamily member 10	Homo sapiens	119-124
31827684-7	2019	Taken together, high levels of ROS induced by SAP may be inhibited by sitagliptin, possibly by inactivating the Nrf2-NF-kappaB pathway.	ros	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	112-116
31827684-7	2019	Taken together, high levels of ROS induced by SAP may be inhibited by sitagliptin, possibly by inactivating the Nrf2-NF-kappaB pathway.	ros	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	117-126
31521245-0	2019	Melatonin alleviates cigarette smoke-induced endothelial cell pyroptosis through inhibiting ROS/NLRP3 axis.	ros	92-95	NLR family pyrin domain containing 3	Homo sapiens	96-101
31521245-7	2019	Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs.	ros	61-64	NLR family pyrin domain containing 3	Homo sapiens	99-104
31521245-7	2019	Additionally, we also observed that N-Acetylcysteine (NAC, a ROS scavenger) pretreatment inhibited NLRP3 inflammasome activation as evidenced by suppressing the upregulation of NLRP3, ASC, cleaved-caspase-1, GSDMD-N, IL-1beta and IL-18 protein levels in CSE-treated ECs.	ros	61-64	NLR family pyrin domain containing 3	Homo sapiens	177-182
31521245-12	2019	In conclusion, our study generated two novel findings, (i) CS activates ROS/NLRP3 axis and induces EC pyroptosis; (ii) melatonin attenuates CS-induced EC pyroptosis by inhibiting ROS/NLRP3 axis.	ros	179-182	NLR family pyrin domain containing 3	Homo sapiens	183-188
31482617-4	2019	Among them, polyphenols possess Nrf2 activation, not only inhibit the production of ROS, inhibit Keap1-Nrf2 protein-protein interaction, but also degrade Keap1 and regulate the Nrf2 related pathway.	ros	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
31229705-10	2019	In addition, inhibiting JNK and ATM/ATR signaling pathways partially rescued the decrease in cell viability, indicating that abamectin-induced ROS overproduction and DNA damage might finally lead to cytotoxicity through JNK and ATM/ATR signaling pathways.	ros	143-146	ataxia telangiectasia and Rad3 related	Mus musculus	232-235
31494106-9	2019	Furthermore, FOXP1 overexpression significantly prevented HG-induced activation of Akt/mTOR signaling in MCs, and Akt activator blocked FOXP1-mediated cell proliferation, ROS production and ECM accumulation in MCs.	ros	171-174	AKT serine/threonine kinase 1	Homo sapiens	114-117
31386778-8	2019	RESULTS: The result showed that ALA-PDT"s anti-proliferation effect and regulation on Socs1/3, JAK1/2 and K17 in IFN-gamma-induced keratinocytes were largely weakened by NAC, indicating that ALA-PDT attenuated the proliferation of IFN-gamma-induced keratinocytes by enhancing ROS level.	ros	276-279	interferon gamma	Mus musculus	113-122
31520993-0	2019	PM2.5 inhibits SOD1 expression by up-regulating microRNA-206 and promotes ROS accumulation and disease progression in asthmatic mice.	ros	74-77	superoxide dismutase 1, soluble	Mus musculus	15-19
31520993-12	2019	miR-206 can target the 3"-UTR of SOD1 to inhibit SOD1 expression, which leads to the increase of ROS level and aggravates pulmonary inflammatory response and asthma symptoms in asthmatic mice.	ros	97-100	superoxide dismutase 1, soluble	Mus musculus	33-37
31513985-12	2019	Expression and secretion of IL-6 as well as generation of ROS were facilitated by TNF-alpha.	ros	58-61	tumor necrosis factor	Homo sapiens	82-91
31520993-12	2019	miR-206 can target the 3"-UTR of SOD1 to inhibit SOD1 expression, which leads to the increase of ROS level and aggravates pulmonary inflammatory response and asthma symptoms in asthmatic mice.	ros	97-100	superoxide dismutase 1, soluble	Mus musculus	49-53
31676852-6	2019	Cytc-knockout cells expressing T58E or T58I Cytc showed a reduction in intact cell respiration, mitochondrial membrane potential ( Psim), ROS production, and apoptotic activity compared to wild-type.	ros	138-141	cytochrome c, somatic	Homo sapiens	0-4
31488013-12	2019	Conclusions: The Nrf2 is inhibited in ORN, resulting more ROS production and oxidative stress.	ros	58-61	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
31485604-0	2019	Overexpression of miR-200a-3p promoted inflammation in sepsis-induced brain injury through ROS-induced NLRP3.	ros	91-94	NLR family pyrin domain containing 3	Homo sapiens	103-108
31417181-9	2019	We demonstrated that the concomitant knockdown of four of these genes products, GPX2, GLRX, ALDH3A1, and PDK4, significantly increased ROS-dependent caspase activation, thus partially mimicking the consequences of NLUCAT1 inactivation in LUAD cells.	ros	135-138	pyruvate dehydrogenase kinase 4	Homo sapiens	105-109
31676852-6	2019	Cytc-knockout cells expressing T58E or T58I Cytc showed a reduction in intact cell respiration, mitochondrial membrane potential ( Psim), ROS production, and apoptotic activity compared to wild-type.	ros	138-141	cytochrome c, somatic	Homo sapiens	44-48
31676852-8	2019	Under conditions of stress Cytc phosphorylations are lost leading to maximal respiration rates,  Psim hyperpolarization, ROS production, and apoptosis.	ros	121-124	cytochrome c, somatic	Homo sapiens	27-31
31481238-6	2019	Activation of the HIF-1 pathway induced by NH4Cl was inhibited by addition of the antioxidant NAC or the NADPH oxidase (NOX) inhibitor apocynin, indicating the involvement of the NOX-induced ROS generation.	ros	191-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-23
31451038-11	2019	This was likely due to the ability of statins to block Rac1 prenylation as geranylgeranyl transferase inhibitors were effective in inhibiting HIV-Nef-induced ROS formation.	ros	158-161	S100 calcium binding protein B	Homo sapiens	146-149
31304745-3	2019	Invoking amyloid cascade, metal ions, and ROS production hypothesis of AD, herein we share our point of view on Cu(II) binding properties of Abeta4-x, the most prevalent N-truncated Abeta peptide, currently known as the main constituent of amyloid plaques.	ros	42-45	amyloid beta precursor protein	Homo sapiens	141-146
31421823-6	2019	After UVB irradiation, treatments with NSC-CM and its secreted factors TIMP-1 and TIMP-2, markedly ameliorated the photodamage triggered by the increase in MMP expression and activity through ROS production, and the subsequent activation of the NF-kappaB pathway in UVB-irradiated fibroblasts and the treatment mouse group.	ros	192-195	tissue inhibitor of metalloproteinase 1	Mus musculus	71-77
31301566-5	2019	Our results characterized 5m as a COX-1/COX-2 balanced inhibitor that subsequently caused ROS inhibition and NF-kappaB suppression, and culminated in the suppression of iNOS, COX-2, TNF-alpha, and IL-6 expression.	ros	90-93	cytochrome c oxidase I, mitochondrial	Mus musculus	34-39
31737170-9	2019	The upregulation of LEGLTBC attenuated HG/PA-induced INS-1 cell injury through the promotion of SIRT1-mediated suppression of ROS accumulation and apoptosis.	ros	126-129	sirtuin 1	Rattus norvegicus	96-101
31601785-6	2019	Taken together, this study for the first time found that the effect of 1, 4-BQ on the crosstalk between autophagy and apoptosis were modulated by the ROS generation via enhancing phosphorylation of Bcl-2(Ser70) and phosphorylation of beclin1(Thr119), which offered a novel insight into underlying molecular mechanisms of benzene-induced hematotoxicity, and specifically how the crosstalk between autophagy and apoptosis was involved in benzene toxicity.	ros	150-153	BCL2 apoptosis regulator	Homo sapiens	198-203
31390228-0	2019	Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through AT1R/ROS/p38MAPK/ADAM17 pathway.	ros	122-125	angiotensinogen	Homo sapiens	0-14
31336140-7	2019	The obtained results indicated that up-regulation of miR-203 reduced myocardial hypertrophy, myocardial fibrosis, myocardial apoptosis, and levels of PIK3CA, PI3K, Akt, CoI I, CoI III, ANP, MDA and ROS in the myocardial tissues, by which DM-induced cardiac dysfunction and pathological changes could be ameliorated.	ros	198-201	microRNA 203	Mus musculus	53-60
31390228-12	2019	In conclusion, Ang II promotes MerTK shedding via AT1R/ROS/p38MAPK/ADAM17 pathway in macrophages, which led to defective efferocytosis and atherosclerosis progression.	ros	55-58	angiotensinogen	Homo sapiens	15-21
31601785-5	2019	Finally, we also found that the elevated ROS was in line with enhancing the phosphorylation of Bcl-2 and beclin1 which contributed to 1, 4-BQ-induced autophagy and apoptosis.	ros	41-44	BCL2 apoptosis regulator	Homo sapiens	95-100
31271820-8	2019	In addition, ginsenoside Rg3 in TNF-alpha-treated myotubes significantly inhibits the production of mitochondrial ROS and restores mitochondrial membrane potential (MMP) and ATP contents.	ros	114-117	tumor necrosis factor	Homo sapiens	32-41
31390228-5	2019	Ang II-activated ADAM17 required ROS and p38 MAPK phosphorylation.	ros	33-36	angiotensinogen	Homo sapiens	0-6
31301277-0	2019	Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer.	ros	82-85	mitogen-activated protein kinase 1	Homo sapiens	95-99
31301277-9	2019	The ROS scavenger NAC markedly diminished G2/M arrest, apoptosis, autophagy and activation of MAPK pathways induced by Rg5.	ros	4-7	mitogen-activated protein kinase 1	Homo sapiens	94-98
31065944-3	2019	We discuss the agonistic effect on the Sirtuin1-PGC-1alpha-PPAR pathway as well as Sirtuin 3, which converge in improving mitochondrial function, decreasing ROS production and ameliorating bioenergetics deficits.	ros	157-160	PPARG coactivator 1 alpha	Homo sapiens	48-58
31176127-3	2019	In vitro study showed that AFB1 (10 muM) significantly increased ROS levels, and decreased T production in Leydig cells by suppressing certain T-biosynthesis gene expressions.	ros	65-68	latexin	Homo sapiens	36-39
31299540-5	2019	Due to the heavy atom effect, ZnPor NPs presented the higher efficiency of ROS generation than that of Por NPs.	ros	75-78	cytochrome p450 oxidoreductase	Homo sapiens	32-35
31132190-6	2019	CONCLUSIONS: These results suggest that dietary activation of NRF2 protects against salt-induced vascular dysfunction, vascular oxidative stress, and microvascular rarefaction by upregulating antioxidant defenses and reducing mitochondrial ROS levels.	ros	240-243	NFE2 like bZIP transcription factor 2	Rattus norvegicus	62-66
31374478-7	2019	Furthermore, the increased expression level of these ligands highly relied on ROS overproduction-triggered DNA damage and the downstream ATM and ATR pathways.	ros	78-81	ATR serine/threonine kinase	Homo sapiens	145-148
31173878-0	2019	Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway.	ros	127-130	NFE2 like bZIP transcription factor 2	Homo sapiens	16-20
31590928-7	2019	We then demonstrated that knockdown of GPX4, CAT, or GSR induced chemoresistance through elevation of ROS level and activation of Nrf2-ABCG2 pathway in BTC cell lines.	ros	102-105	catalase	Homo sapiens	45-48
31301116-6	2019	Blockage of P2Y11R by its antagonist suppresses IL-1beta-induced TNF-alpha and IL-6 induction and ameliorates oxidative stress as determined by levels of cellular ROS and the oxidative byproduct 4-HNE.	ros	163-166	interleukin 1 beta	Homo sapiens	48-56
31657761-11	2019	There is a negative correlation between the expression of ABCG2 and the ROS production in the corresponding tissues under heat stress.	ros	72-75	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	58-63
31065944-3	2019	We discuss the agonistic effect on the Sirtuin1-PGC-1alpha-PPAR pathway as well as Sirtuin 3, which converge in improving mitochondrial function, decreasing ROS production and ameliorating bioenergetics deficits.	ros	157-160	sirtuin 3	Homo sapiens	83-92
31252067-0	2019	Cadmium exposure induces interleukin-6 production via ROS-dependent activation of the ERK1/2 but independent of JNK signaling pathway in human placental JEG-3 trophoblast cells.	ros	54-57	interleukin 6	Homo sapiens	25-38
31252067-0	2019	Cadmium exposure induces interleukin-6 production via ROS-dependent activation of the ERK1/2 but independent of JNK signaling pathway in human placental JEG-3 trophoblast cells.	ros	54-57	mitogen-activated protein kinase 3	Homo sapiens	86-92
31252067-10	2019	These data indicate that Cd induces IL-6 production in trophoblast cells through a ROS-dependent activation of ERK1/2.	ros	83-86	interleukin 6	Homo sapiens	36-40
31252067-10	2019	These data indicate that Cd induces IL-6 production in trophoblast cells through a ROS-dependent activation of ERK1/2.	ros	83-86	mitogen-activated protein kinase 3	Homo sapiens	111-117
31506393-6	2019	We found that both K-562 and THP-1 cells have multi fold high levels of HK II, glucose uptake and endogenous ROS with respect to normal PBMCs.	ros	109-112	GLI family zinc finger 2	Homo sapiens	29-34
31381934-13	2019	The results showed that p38-MAPK pathway plays an important role in PQ-caused alveolar epithelial cell insult, and ghrelin might attenuate PQ-induced cell injury by inhibiting ROS-induced p38-MAPK modulated mitochondrial apoptotic pathway.	ros	176-179	mitogen-activated protein kinase 14	Homo sapiens	188-191
31283929-0	2019	ROS -mediated p53 activation by juglone enhances apoptosis and autophagy in vivo and in vitro.	ros	0-3	tumor protein p53	Homo sapiens	14-17
31202128-5	2019	Along with the increase of endogenous ROS and Ca2+ levels, mitochondrial membrane potential collapse and massive release of cytochrome c, it is fully demonstrated that these complexes induce apoptosis through ROS-mediated mitochondrial pathway.	ros	209-212	cytochrome c, somatic	Homo sapiens	124-136
31233740-4	2019	Effectively, in TNFalpha-stimulated 18Co cells RE decreases ROS production and increases Sirt-1 expression and activity, but it reduces TNFalpha-induced ICAM-1 up-regulation by a Sirt-1-independent mechanism, as demonstrated by EX527 and Sirt-1 siRNA treatments.	ros	60-63	tumor necrosis factor	Homo sapiens	16-24
31233740-5	2019	RE inhibits TNFalpha-induced activation of NF-kappaB by reducing both ROS and the degradation of IkappaB-alpha, an endogenous inhibitor of NF-kappaB, with consequent decrease of NF-kappaB nuclear translocation.	ros	70-73	tumor necrosis factor	Homo sapiens	12-20
31233740-5	2019	RE inhibits TNFalpha-induced activation of NF-kappaB by reducing both ROS and the degradation of IkappaB-alpha, an endogenous inhibitor of NF-kappaB, with consequent decrease of NF-kappaB nuclear translocation.	ros	70-73	nuclear factor kappa B subunit 1	Homo sapiens	43-52
31283929-10	2019	Overall, our results illustrated that JG caused apoptosis and autophagy via activating the ROS-mediated p53 pathway in human liver cancer cells in vitro and in vivo, which provided basic scientific evidence that JG serves as a potential anti-cancer agent.	ros	91-94	tumor protein p53	Homo sapiens	104-107
31303273-4	2019	Here we first showed that SIRT3, the major mitochondrial deacetylase, is negatively correlated to DOX-induced cardiotoxicity through the regulation of ATP production, mitochondrial membrane potential (MMP) level and ROS level in human pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).	ros	216-219	sirtuin 3	Homo sapiens	26-31
31394125-11	2019	Activation of p38 MAPK pathway or inhibition of Nrf2 significantly reversed the protective effects of linderane against STZ-induced ROS production and cell apoptosis.	ros	132-135	NFE2 like bZIP transcription factor 2	Rattus norvegicus	48-52
31754331-7	2019	Moreover, PGC-1alpha and SOD1 were upregulated in accordance with the increased ROS production in IS patients.	ros	80-83	PPARG coactivator 1 alpha	Homo sapiens	10-20
31754331-7	2019	Moreover, PGC-1alpha and SOD1 were upregulated in accordance with the increased ROS production in IS patients.	ros	80-83	superoxide dismutase 1	Homo sapiens	25-29
31136867-6	2019	The coating of FIB on QDs could lower intracellular QDs uptake and therefore result in less released cadmium ions and ROS productions.	ros	118-121	fibrinogen beta chain	Homo sapiens	15-18
31492195-6	2019	CONCLUSIONS: Our results collectively suggest that astilbin could induce Nrf2 nucleus translocation, which is contribute to reduce the ROS accumulation and VEGF expression, and inhibit the proliferation of HaCaT cells.	ros	135-138	NFE2 like bZIP transcription factor 2	Homo sapiens	73-77
31226635-9	2019	Moreover, ectopic-expression of miR-130a can significantly improve cell survival rate and reduce cell apoptosis and ROS production in PC12 cells after OGDR.	ros	116-119	microRNA 130a	Rattus norvegicus	32-40
30982974-10	2019	Interestingly, AhR antagonist CH223191 or cells with AhR knockdown abrogated the increased expression of ROS, TSLP, and IL-33.	ros	105-108	aryl-hydrocarbon receptor	Mus musculus	15-18
30982974-10	2019	Interestingly, AhR antagonist CH223191 or cells with AhR knockdown abrogated the increased expression of ROS, TSLP, and IL-33.	ros	105-108	aryl-hydrocarbon receptor	Mus musculus	53-56
30982974-13	2019	CONCLUSIONS: Our findings suggest that BaP facilitates Der f 1-induced epithelial cytokine release through the AhR-ROS axis.	ros	115-118	aryl-hydrocarbon receptor	Mus musculus	111-114
31255993-8	2019	RESULTS: Inhibition of HDAC6 inhibited the overproduction of ROS and suppressed the expression of pro-inflammatory cytokines such as TNF-alpha, IL-1beta, and IL-6 in LPS-activated RAW264.7 cells.	ros	61-64	histone deacetylase 6	Mus musculus	23-28
31241172-8	2019	KEY RESULTS: Ibudilast, an anti-asthmatic drug, attenuated ROS-mediated muscle toxicity induced by doxorubicin treatment or passive smoking, by inhibiting the functional interactions between TRPC3 channels and Nox2, without reducing TRPC3 channel activity.	ros	59-62	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	191-196
31069623-12	2019	Graphical Abstract FTY720 may reduce ROS production by inhibiting the PI3K/AKT/GSK-3beta signaling pathway, while at the same time reducing p65 phosphorylation, thus decreasing NLRP3 inflammasome activation through these two pathways, ultimately reducing microglia activation-induced neuronal damage.	ros	37-40	thymoma viral proto-oncogene 1	Mus musculus	75-78
31176117-6	2019	Further the results demonstrated that ROS generated by cuboid and rod shaped nanopolymorphs activated the pro-angiogenic factors namely VE-cadherin, HIF 1alpha, VEGF and VEGFR-2 to facilitate the angiogenic process.	ros	38-41	cadherin 5	Homo sapiens	136-147
31176117-6	2019	Further the results demonstrated that ROS generated by cuboid and rod shaped nanopolymorphs activated the pro-angiogenic factors namely VE-cadherin, HIF 1alpha, VEGF and VEGFR-2 to facilitate the angiogenic process.	ros	38-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	149-159
31176117-6	2019	Further the results demonstrated that ROS generated by cuboid and rod shaped nanopolymorphs activated the pro-angiogenic factors namely VE-cadherin, HIF 1alpha, VEGF and VEGFR-2 to facilitate the angiogenic process.	ros	38-41	vascular endothelial growth factor A	Homo sapiens	161-165
31238070-3	2019	SIRT2 is a major regulator of mitochondria to mediate ROS production.	ros	54-57	sirtuin 2	Sus scrofa	0-5
30464225-9	2019	Furthermore, BICD1 silencing abolished hypoxia-induced glycolytic reprogramming and increased mitochondrial ROS accumulation and apoptosis in UCB-MSCs under hypoxia.	ros	108-111	BICD cargo adaptor 1	Homo sapiens	13-18
31136780-7	2019	Notably, MPG substantially suppressed the significant elevation of ROS production in hepatocytes of mice intoxicated with CCl4.	ros	67-70	N-methylpurine-DNA glycosylase	Mus musculus	9-12
31153974-14	2019	Therapeutic strategy to restrain ROS/ERS/iRhom2 signaling pathway could be developed to prevent myocardial inflammation and lipid deposition, consequently alleviating obesity-induced cardiomyopathy.	ros	33-36	rhomboid 5 homolog 2	Mus musculus	41-47
31404628-1	2019	induces apoptotic and autophagic cell death via the ROS triggered mTOR signaling pathway in non-small cell lung cancer.	ros	52-55	mechanistic target of rapamycin kinase	Homo sapiens	66-70
31404628-12	2019	Furthermore, the mTOR signaling pathway was regulated by the increased ROS as the initial signal in A549 and H1299 cells.	ros	71-74	mechanistic target of rapamycin kinase	Homo sapiens	17-21
31404628-14	2019	Taken together, our data have firstly demonstrated that PPVI is the main component in TTM that exerts the anti-proliferative effect by inducing apoptotic and autophagic cell death in NSCLC via the ROS-triggered mTOR signaling pathway, and PPVI may be a promising candidate for the treatment of NSCLC in future.	ros	197-200	mechanistic target of rapamycin kinase	Homo sapiens	211-215
31344643-1	2019	SOD1 is commonly known for its ROS scavenging activity, but recent work has uncovered additional roles in modulating metabolism, maintaining redox balance, and regulating transcription.	ros	31-34	superoxide dismutase 1	Homo sapiens	0-4
31421410-12	2019	In accordance, calcitriol also attenuated Ang II-induced Nox activation and ROS production, and shifted the microglia polarization from M1 to M2 phenotype.	ros	76-79	angiotensinogen	Rattus norvegicus	42-48
31132430-7	2019	Using genetic overexpression and knockdown of NRF2, we found that NRF2 has a critical role in suppressing ABS-induced ROS levels, oxidative DNA damage, DNA double strand breaks, and apoptosis.	ros	118-121	NFE2 like bZIP transcription factor 2	Homo sapiens	46-50
31152818-0	2019	Peroxynitrite contributes to arsenic-induced PARP-1 inhibition through ROS/RNS generation.	ros	71-74	poly(ADP-ribose) polymerase 1	Homo sapiens	45-51
31152818-2	2019	The zinc finger DNA repair protein Poly (ADP-ribose) polymerase 1 (PARP-1) is a sensitive target of AsIII and both reactive oxygen and nitrogen species (ROS/RNS) generated by AsIII contribute to PARP-1 inhibition.	ros	153-156	poly(ADP-ribose) polymerase 1	Homo sapiens	67-73
31152818-2	2019	The zinc finger DNA repair protein Poly (ADP-ribose) polymerase 1 (PARP-1) is a sensitive target of AsIII and both reactive oxygen and nitrogen species (ROS/RNS) generated by AsIII contribute to PARP-1 inhibition.	ros	153-156	poly(ADP-ribose) polymerase 1	Homo sapiens	195-201
31152818-3	2019	However, the mechanisms of ROS/RNS-mediated PARP inhibition and how AsIII-generated ROS/RNS may be interconnected are still unclear.	ros	27-30	poly(ADP-ribose) polymerase 1	Homo sapiens	44-48
31132430-7	2019	Using genetic overexpression and knockdown of NRF2, we found that NRF2 has a critical role in suppressing ABS-induced ROS levels, oxidative DNA damage, DNA double strand breaks, and apoptosis.	ros	118-121	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
31507536-5	2019	In vitro studies using vascular smooth muscle cells found that pre-treatment with the GPER agonist G-1 inhibited Ang II-induced ROS and NADP/NADPH.	ros	128-131	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	113-119
31695327-8	2019	Subsequently, intracellular hydrogen peroxide (H2O2) and the activation of ROS/JNK pathway were detected.	ros	75-78	mitogen-activated protein kinase 8	Homo sapiens	79-82
31507536-8	2019	We conclude that during conditions of elevated Ang II, GPER via the cAMP pathway suppresses Nox4 transcription to limit ROS production and prevent arterial stiffening.	ros	120-123	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	47-53
31266772-6	2019	Reduced expression of HIF2alpha inhibited the self-renewal of Sca-1+ cells; this effect was blocked through suppression of ROS by N-acetyl cysteine or the knockdown of p53, Nanog, or Sox2.	ros	123-126	ataxin 1	Homo sapiens	62-67
31130519-4	2019	We determined that PAA covalently binds to the conserved cysteine site of peroxiredoxins I/II (Prxs-I/II) and inhibits their catalytic activity, subsequently activating the ROS/ERK axis and the immunogenicity of HCC toward NK cells.	ros	173-176	mitogen-activated protein kinase 1	Homo sapiens	177-180
31429763-7	2019	Overexpression of NFAT5 activates NLRP3-inflammasome and increases the secretion of IL-1beta in ECs partly via ROS.	ros	111-114	interleukin 1 beta	Mus musculus	84-92
31456939-0	2019	Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3.	ros	104-107	signal transducer and activator of transcription 3	Homo sapiens	144-149
31485193-0	2019	RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose.	ros	50-53	NLR family pyrin domain containing 3	Homo sapiens	54-59
31485193-1	2019	Background: Hyperglycemia plays a vital role in diabetic nephropathy (DN); autophagy and its potential upregulator receptor-interacting protein kinase 2 (RIPK2) are associated with ROS, which play a potential role in regulating NLRP3, and may be involved in inflammation in DN.	ros	181-184	NLR family pyrin domain containing 3	Homo sapiens	228-233
31485193-2	2019	Aim: In this study, we aimed to explore the mechanisms mediated by RIPK2 in autophagy and the relationship with ROS-NLRP3 of DN, by investigating the levels of RIPK2 and autophagy in glomerular mesangial cells (GMCs) stimulated with high glucose.	ros	112-115	NLR family pyrin domain containing 3	Homo sapiens	116-121
31485193-10	2019	RIPK2 regulates ROS-NLRP3 inflammasome signaling through autophagy and may be involved in the pathogenesis of DN.	ros	16-19	NLR family pyrin domain containing 3	Homo sapiens	20-25
31456939-5	2019	Mechanistically, we demonstrated that carnosol suppressed the activation of STAT3 signaling pathway through a ROS-dependent targeting of STAT3 to proteasome-degradation in breast cancer cells (MDA-MB-231, Hs578T, MCF-7, and T47D).	ros	110-113	signal transducer and activator of transcription 3	Homo sapiens	76-81
31412764-5	2019	Besides, the levels of antioxidant enzymes, glutathione (GSH) and ascorbate peroxidase (APX) exhibited continuously increasing trends, with approximately threefold higher than the control, implying that these ROS-scavenging enzymes were responsible for the detoxification of ROS induced by drought and cold stresses.	ros	209-212	peroxidase 42-like	Gossypium hirsutum	76-86
31412804-0	2019	Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux.	ros	128-131	NLR family pyrin domain containing 3	Homo sapiens	20-25
31412804-10	2019	Furthermore, we identified that UA regulated the activation of NLRP3 inflammasome by activating ROS and K+ efflux.	ros	96-99	NLR family pyrin domain containing 3	Homo sapiens	63-68
31412804-13	2019	CONCLUSIONS: UA could regulate NLRP3/IL-1beta signaling pathway through ROS activation and K+ efflux and further induce vascular endothelial cells injury in early stages of CKD.	ros	72-75	NLR family pyrin domain containing 3	Homo sapiens	31-36
31440159-4	2019	Our results demonstrated that cisplatin induced PTGS2 expression through the ROS-ERK1/2-NF-kappaB signaling axis.	ros	77-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	48-53
31440159-4	2019	Our results demonstrated that cisplatin induced PTGS2 expression through the ROS-ERK1/2-NF-kappaB signaling axis.	ros	77-80	mitogen-activated protein kinase 3	Homo sapiens	81-87
31456939-5	2019	Mechanistically, we demonstrated that carnosol suppressed the activation of STAT3 signaling pathway through a ROS-dependent targeting of STAT3 to proteasome-degradation in breast cancer cells (MDA-MB-231, Hs578T, MCF-7, and T47D).	ros	110-113	signal transducer and activator of transcription 3	Homo sapiens	137-142
31456939-6	2019	We show that blockade of proteasome activity, by MG-132 and bortezomib, or ROS accumulation, by N-acetylcysteine (NAC), restored the level of STAT3 protein.	ros	75-78	signal transducer and activator of transcription 3	Homo sapiens	142-147
30608002-6	2019	Meanwhile, Rg1 reduced the excessive ROS and the occurrence of cell apoptosis, which were related to Nrf2/ARE pathway.	ros	37-40	nuclear factor, erythroid derived 2, like 2	Mus musculus	101-105
31398912-7	2019	In addition, 5-7HP inhibited PM-induced ROS generation and then downregulated ROS-mediated COX-2 and MMP9 production and AQP-3 consumption by inhibiting the phosphorylation of MAPKs.	ros	78-81	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
31515638-4	2019	Both uPA and TNFalpha induce ROS generation in monocytes, while MMP-9 secretion induced by uPA and TNFalpha is inhibited by antioxidants.	ros	29-32	plasminogen activator, urokinase	Homo sapiens	5-8
31515638-4	2019	Both uPA and TNFalpha induce ROS generation in monocytes, while MMP-9 secretion induced by uPA and TNFalpha is inhibited by antioxidants.	ros	29-32	tumor necrosis factor	Homo sapiens	13-21
31391058-10	2019	Moreover, Jinfukang induces apoptosis in CTC-TJH-01 cells through the ROS-mediated ATM/ATR-p53 pathway and DNA damage.	ros	70-73	ATR serine/threonine kinase	Homo sapiens	87-90
31391058-10	2019	Moreover, Jinfukang induces apoptosis in CTC-TJH-01 cells through the ROS-mediated ATM/ATR-p53 pathway and DNA damage.	ros	70-73	tumor protein p53	Homo sapiens	91-94
31004702-5	2019	STAMBPL1 knockdown-induced apoptosis was accompanied by accumulation of cellular ROS and a decrease in endogenous caspase inhibitor XIAP protein content.	ros	81-84	STAM binding protein like 1	Homo sapiens	0-8
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	ros	64-67	transforming growth factor beta 1	Homo sapiens	117-126
30633345-0	2019	Fibrinopeptide A induces C-reactive protein expression through the ROS-ERK1/2/p38-NF-kappaB signal pathway in the human umbilical vascular endothelial cells.	ros	67-70	C-reactive protein	Homo sapiens	25-43
30633345-0	2019	Fibrinopeptide A induces C-reactive protein expression through the ROS-ERK1/2/p38-NF-kappaB signal pathway in the human umbilical vascular endothelial cells.	ros	67-70	mitogen-activated protein kinase 3	Homo sapiens	71-77
30633345-9	2019	These results indicate that FPA induces CRP expression in HUVECs via the ROS-ERK1/2/p38-NF-kappaB signal pathway.	ros	73-76	C-reactive protein	Homo sapiens	40-43
30633345-9	2019	These results indicate that FPA induces CRP expression in HUVECs via the ROS-ERK1/2/p38-NF-kappaB signal pathway.	ros	73-76	mitogen-activated protein kinase 3	Homo sapiens	77-83
31444868-4	2019	Tafazzin (Taz) is a mitochondrial-specific transacylase that regulates mature cardiolipin (CL) formation, and its absence leads to mitochondrial dysfunction and excessive production of reactive oxygen/nitrogen species (ROS/RNS).	ros	219-222	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	0-8
31444868-4	2019	Tafazzin (Taz) is a mitochondrial-specific transacylase that regulates mature cardiolipin (CL) formation, and its absence leads to mitochondrial dysfunction and excessive production of reactive oxygen/nitrogen species (ROS/RNS).	ros	219-222	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	10-13
31444868-10	2019	Nonetheless, we demonstrate for the first time that SERCA function is impaired in LVs obtained from young and old TazKD mice likely due to elevated ROS/RNS production.	ros	148-151	ATPase, Ca++ transporting, ubiquitous	Mus musculus	52-57
31368573-8	2019	The findings of this study show that HFD-CO, and through the increasing generation of ROS and IL-6 levels and shedding, could activate LV JAK1/2-STAT1/3  and  renin-angiotensin system (RAS) signaling pathways, thus creating a positive feedback between the two which ultimately leads to activation of TGF-1beta/Smad3 fibrotic pathway.	ros	86-89	SMAD family member 3	Rattus norvegicus	310-315
31004300-5	2019	P2X7R, Bax, and Caspase-3 protein expression were detected by western blot and immunofluorescence analysis.The expression of P2X7R, ROS, Bax, and Caspase-3 in human podocytes incubated with oxLDL was significantly up-regulated and was found to have higher intracellular lipid accumulation and podocyte apoptosis compared with the NC group.	ros	132-135	caspase 3	Homo sapiens	146-155
31366086-5	2019	Depletion of p53 coincided with a moderate, LA-dependent ROS production, but was not rescued by antioxidant treatment.	ros	57-60	tumor protein p53	Homo sapiens	13-16
31336672-9	2019	In fact, activation of vitagenes via such transcription factors as Nrf2 leads to an additional synthesis of an array of protective molecules which can deal with increased ROS/RNS production.	ros	171-174	NFE2 like bZIP transcription factor 2	Homo sapiens	67-71
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	ros	64-67	interleukin 6	Homo sapiens	131-135
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	276-279	transforming growth factor beta 1	Homo sapiens	61-70
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	276-279	interleukin 6	Homo sapiens	75-79
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	364-367	transforming growth factor beta 1	Homo sapiens	61-70
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	364-367	interleukin 6	Homo sapiens	75-79
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	ros	116-119	transforming growth factor beta 1	Homo sapiens	151-160
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	ros	116-119	interleukin 6	Homo sapiens	165-169
31409992-4	2019	Methods: In the present study, the interaction of SiO2 NPs with CAT and human MSCs (hMSCs) was explored by various spectroscopic methods (fluorescence, circular dichroism (CD), UV-visible), molecular docking and dynamics studies, and cellular (MTT, cellular morphology, cellular uptake, lactate dehydrogenase, ROS, caspase-3, flow cytometry) assays.	ros	310-313	catalase	Homo sapiens	64-67
31324798-4	2019	beta-Lapachone is catalyzed and bioactivated by NQO1 to generate ROS in NQO1high tumor cells triggering oxidative stress and release of the damage signals for innate sensing.	ros	65-68	NAD(P)H quinone dehydrogenase 1	Homo sapiens	48-52
31318905-8	2019	This study demonstrates that hypoxia induces HK-2 cell apoptosis through a signaling pathway involving TGF-beta1 via Smad pathway induction of Nox4-dependent ROS generation.	ros	158-161	transforming growth factor beta 1	Homo sapiens	103-112
31379986-9	2019	Interestingly, HER2-positive cells showed the highest increase in intracellular ROS after oxidative challenge, concomitant with a significantly higher level of AQP1, AQP3, and AQP5 expression compared to the other cell types, with AQP3 always being the most expressed isoform.	ros	80-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	15-19
31337986-0	2019	YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway.	ros	118-121	mechanistic target of rapamycin kinase	Homo sapiens	122-126
31337986-9	2019	Mechanistically, YAP silencing significantly enhanced autophagic flux by increasing RAC1-driven ROS, which contributed to the inactivation of mTOR in HCC cells.	ros	96-99	mechanistic target of rapamycin kinase	Homo sapiens	142-146
31337986-11	2019	Conclusion: Our findings suggested that YAP upregulation endowed HCC cells with multi-drug resistance via the RAC1-ROS-mTOR pathway, resulting in the repression of autophagy-related cell death.	ros	115-118	mechanistic target of rapamycin kinase	Homo sapiens	119-123
31222103-7	2019	We show that activation of the oncogene ErbB2 is associated with increased ROS and that high ROS sub-population of ErbB2 cancer cells show elevated SOD1.	ros	93-96	superoxide dismutase 1, soluble	Mus musculus	148-152
31291988-12	2019	ATG4C depletion suppressed autophagy and triggered apoptosis through ROS accumulation.	ros	69-72	autophagy related 4C cysteine peptidase	Homo sapiens	0-5
31338328-10	2019	The enhancement of PDT efficacy mediated by Cx40 channels was related with intracellular pathways mediated by ROS and calcium pathways, but not the lipid peroxide-mediated pathway.	ros	110-113	gap junction protein alpha 5	Homo sapiens	44-48
31277230-4	2019	Mechanistically, AF/CE combination induced severe oxidative stress that caused ROS-mediated inhibition of hexokinase (HK) and a disturbance of mitochondrial redox homeostasis, resulting in a significant decrease of ATP generation.	ros	79-82	hexokinase 1	Homo sapiens	106-116
31277230-4	2019	Mechanistically, AF/CE combination induced severe oxidative stress that caused ROS-mediated inhibition of hexokinase (HK) and a disturbance of mitochondrial redox homeostasis, resulting in a significant decrease of ATP generation.	ros	79-82	hexokinase 1	Homo sapiens	118-120
30902796-5	2019	Furthermore, alisertib treatment disrupted the immunosuppressive functions of MDSC by inhibiting Stat3-mediated ROS production.	ros	112-115	signal transducer and activator of transcription 3	Mus musculus	97-102
31066219-0	2019	ER alpha selective chromone, isoxazolylchromones, induces ROS-mediated cell death without autophagy.	ros	58-61	estrogen receptor 1	Homo sapiens	0-8
31298304-12	2019	BK significantly inhibited the proliferation of hRECs cells, enhanced Caspase-3 activity, decreased the content of LDH and ROS, increased SOD activity, reduced the expressions of HMGB-1 and NF-kappaB protein, attenuated the expression of VEGF, and restrained the secretion of TNF-alpha and IL-1beta compared with high glucose group (p &lt; 0.05).	ros	123-126	kininogen 1	Homo sapiens	0-2
31053403-0	2019	Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer.	ros	48-51	nuclear receptor subfamily 4 group A member 1	Homo sapiens	0-20
31053403-0	2019	Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer.	ros	48-51	nuclear receptor subfamily 4 group A member 1	Homo sapiens	22-27
31053403-0	2019	Nuclear receptor 4A1 (NR4A1) antagonists induce ROS-dependent inhibition of mTOR signaling in endometrial cancer.	ros	48-51	mechanistic target of rapamycin kinase	Homo sapiens	76-80
30986766-6	2019	Further, AR inhibition prevented the HG-induced ROS generation and expression of BCL-2, BAX and activation of Caspase-3 in HUVECs.	ros	48-51	aldo-keto reductase family 1 member B	Homo sapiens	9-11
30949935-6	2019	We also found that TNFalpha treatment was associated with mitochondrial stress, including mitochondrial ROS overloading, mitochondrial permeability transition pore (mPTP) opening, mitochondrial membrane potential reduction, and mitochondrial pro-apoptotic factor release.	ros	104-107	tumor necrosis factor	Mus musculus	19-27
31277696-11	2019	Our results show that the antioxidative enzyme level and the ratio of Bcl-2/Bax decrease, the expression level of caspase 3 increases, the mitochondrial membrane potential is abnormal, and ROS accumulate in this system.	ros	189-192	caspase 3	Homo sapiens	114-123
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	ros	4-7	cyclin dependent kinase inhibitor 1A	Homo sapiens	131-134
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	ros	4-7	checkpoint kinase 1	Homo sapiens	180-184
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	ros	4-7	cyclin A2	Homo sapiens	190-198
31384532-7	2019	We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway.	ros	173-176	thioredoxin interacting protein	Mus musculus	177-182
30951611-0	2019	Reversing ROS-mediated neurotoxicity by chlorogenic acid involves its direct antioxidant activity and activation of Nrf2-ARE signaling pathway.	ros	10-13	NFE2 like bZIP transcription factor 2	Rattus norvegicus	116-120
30954547-0	2019	The apoptosis and GLP-1 hyposecretion induced by LPS via RIP/ROS/mTOR pathway in GLUTag cells.	ros	61-64	toll-like receptor 4	Mus musculus	49-52
30954547-6	2019	RIP1 and RIP3 knockdown increased cell viability, the mRNA and protein levels of GLP-1 and the mTOR signaling pathway-related proteins (p-mTOR and p-S6), and decreased the relative caspase 3/7 activity, cell apoptosis and ROS production.	ros	222-225	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	0-4
30954547-6	2019	RIP1 and RIP3 knockdown increased cell viability, the mRNA and protein levels of GLP-1 and the mTOR signaling pathway-related proteins (p-mTOR and p-S6), and decreased the relative caspase 3/7 activity, cell apoptosis and ROS production.	ros	222-225	myosin phosphatase Rho interacting protein	Mus musculus	9-13
30954547-10	2019	Taken together, our result revealed that LPS induced the apoptosis of GLUTag cells and GLP-1 hyposecretion through the RIP/ROS/mTOR pathway.	ros	123-126	toll-like receptor 4	Mus musculus	41-44
30777466-0	2019	Bufalin induces apoptosis via mitochondrial ROS-mediated caspase-3 activation in HCT-116 and SW620 human colon cancer cells.	ros	44-47	caspase 3	Homo sapiens	57-66
30777466-12	2019	CONCLUSION: Bufalin significantly induces apoptosis in HCT-116 and SW620 colon cancer cells via mitochondrial ROS-mediated caspase-3 activation.	ros	110-113	caspase 3	Homo sapiens	123-132
30919410-3	2019	Our group recently demonstrated that Brucella abortus-induced IL-1beta secretion involves NLRP3 inflammasome and it is partially dependent on mitochondrial ROS production.	ros	156-159	interleukin 1 beta	Mus musculus	62-70
30993568-0	2019	PGC-1alpha protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury through ROS-p38 pathway.	ros	124-127	PPARG coactivator 1 alpha	Homo sapiens	0-10
30993568-0	2019	PGC-1alpha protects against oxidized low-density lipoprotein and luteinizing hormone-induced granulosa cells injury through ROS-p38 pathway.	ros	124-127	mitogen-activated protein kinase 14	Homo sapiens	128-131
30993568-12	2019	Our data also revealed that over-expression of PGC-1alpha in GCs from women of normal reproductive age at normal-weight markedly inhibited cell injury, ROS generation and p38 activation, accompanied by increased Bcl-2 expression, decreased Bax and cleaved caspase-3 expressions induced by ox-LDL + LH stimulation.	ros	152-155	PPARG coactivator 1 alpha	Homo sapiens	47-57
30993568-14	2019	Attenuation of ROS generation reversed ox-LDL + LH-induced p38 activation, however, p38 inhibitors had an effect on ROS generation.	ros	15-18	mitogen-activated protein kinase 14	Homo sapiens	59-62
30993568-14	2019	Attenuation of ROS generation reversed ox-LDL + LH-induced p38 activation, however, p38 inhibitors had an effect on ROS generation.	ros	116-119	mitogen-activated protein kinase 14	Homo sapiens	84-87
30993568-16	2019	And, the mechanism may be related to the inhibition of ROS-initiated p38 pathway.	ros	55-58	mitogen-activated protein kinase 14	Homo sapiens	69-72
31354907-7	2019	The mechanistic study suggested that growth inhibition was related to ROS-mediated apoptosis, and ROS production was due to SOD inhibition initiated by DpdtbA rather than occurrence of ferritinophagy.	ros	98-101	superoxide dismutase 1	Homo sapiens	124-127
31222103-9	2019	Based on these results, we suggest that SOD1 carries a housekeeping function that maintains ROS levels below a threshold that supports oncogene-dependent proliferation, while allowing escape from oncogene-induced senescence, independently of the oncogene driving tumor formation.	ros	92-95	superoxide dismutase 1, soluble	Mus musculus	40-44
31233552-13	2019	These data suggested that L. amazonensis elimination mediated by P2X7 receptor and LTB4 was dependent on non-canonical NLRP3 inflammasome activation, ROS production, and IL-1beta signaling.	ros	150-153	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	65-69
31084929-0	2019	Angiotensin II downregulates vascular endothelial cell hydrogen sulfide production by enhancing cystathionine gamma-lyase degradation through ROS-activated ubiquitination pathway.	ros	142-145	angiotensinogen	Homo sapiens	0-14
31316342-7	2019	In addition, PARK20 fibroblasts reveal upregulation of oxidative stress markers and total ROS production with concomitant alteration of the morphology of the mitochondrial network.	ros	90-93	synaptojanin 1	Homo sapiens	13-19
31316342-8	2019	Interestingly, treatment of PARK20 cells with GSK2606414 (GSK), a specific inhibitor of PERK activity, restores the level of ROS, signaling a direct correlation between ER stress and the induction of oxidative stress in the PARK20 cells.	ros	125-128	synaptojanin 1	Homo sapiens	28-34
31316342-8	2019	Interestingly, treatment of PARK20 cells with GSK2606414 (GSK), a specific inhibitor of PERK activity, restores the level of ROS, signaling a direct correlation between ER stress and the induction of oxidative stress in the PARK20 cells.	ros	125-128	synaptojanin 1	Homo sapiens	224-230
31084929-7	2019	Furthermore, we found that superoxide anion levels were significantly increased in AngII-treated endothelial cells compared with controls and that the ROS scavenger N-acetyl-l-cysteine (NAC) significantly abolished CSE ubiquitination.	ros	151-154	angiotensinogen	Homo sapiens	83-88
31084929-8	2019	Taken together, our data suggested that AngII inhibited endogenous H2S generation through ubiquitination-mediated CSE degradation via the ROS pathway in vascular endothelial cells.	ros	138-141	angiotensinogen	Homo sapiens	40-45
31216990-0	2019	SAA1 increases NOX4/ROS production to promote LPS-induced inflammation in vascular smooth muscle cells through activating p38MAPK/NF-kappaB pathway.	ros	20-23	serum amyloid A1	Homo sapiens	0-4
31220110-9	2019	Mitochondrial damage and intracellular ROS production were observed upon treatment with AgNPs (10mug/mL) and PDT (0.5 mJ/cm2) showed significant reducing cell migration, expression of Bax and suppression of Bcl-2.	ros	39-42	BCL2 associated X, apoptosis regulator	Homo sapiens	184-187
31220110-9	2019	Mitochondrial damage and intracellular ROS production were observed upon treatment with AgNPs (10mug/mL) and PDT (0.5 mJ/cm2) showed significant reducing cell migration, expression of Bax and suppression of Bcl-2.	ros	39-42	BCL2 apoptosis regulator	Homo sapiens	207-212
31172987-6	2019	WZ35, a novel curcumin derivative, exhibits potential anti-tumor activity in gastric cancer cells by regulating ROS dependent JNK activation and ER stress.	ros	112-115	mitogen-activated protein kinase 8	Homo sapiens	126-129
31216990-9	2019	Recombinant SAA1 protein could increase NOX4/ROS production and promote the release of inflammatory factors (IL-1beta, IL-6, IL-8, IL-17, TNF-alpha and MCP-1) in LPS (1 mug/ml) - induced VSMCs.	ros	45-48	serum amyloid A1	Homo sapiens	12-16
31216990-12	2019	CONCLUSION: SAA1-mediated NOX4/ROS pathway could activate p38MAPK/NF-kappaB pathway, thereby contributing to the release of inflammatory factors in LPS-induced VSMCs.	ros	31-34	serum amyloid A1	Homo sapiens	12-16
31417254-11	2019	Nrf2 inhibitor (ML385) abolished the regulatory effect of SeNPs on intracellular ROS production.	ros	81-84	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
31098605-0	2019	Role of PTA in the prevention of Cu(amyloid-beta) induced ROS formation and amyloid-beta oligomerisation in the presence of Zn.	ros	58-61	amyloid beta precursor protein	Homo sapiens	36-48
31360100-8	2019	Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages.	ros	147-150	NLR family pyrin domain containing 3	Homo sapiens	57-62
30878009-0	2019	The effects of cooking oil fumes-derived PM2.5 on blood vessel formation through ROS-mediated NLRP3 inflammasome pathway in human umbilical vein endothelial cells.	ros	81-84	NLR family pyrin domain containing 3	Homo sapiens	94-99
30878009-3	2019	Here, to test the role of ROS-mediated NLRP3 inflammasome pathway in blood vessel formation of human umbilical vein endothelial cells (HUVECs) caused by COFs-derived PM2.5, the cells were exposed to COFs-derived PM2.5 at different concentrations with and without N-acetyl-L-cysteine (NAC).	ros	26-29	NLR family pyrin domain containing 3	Homo sapiens	39-44
30878009-13	2019	It was revealed that the impact caused by COFs-derived PM2.5 on blood vessel formation through a ROS-mediated NLRP3 inflammasome pathway.	ros	97-100	NLR family pyrin domain containing 3	Homo sapiens	110-115
31285773-0	2019	Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms.	ros	45-48	mitogen-activated protein kinase 1	Mus musculus	78-81
31285773-0	2019	Vitamin C kills thyroid cancer cells through ROS-dependent inhibition of MAPK/ERK and PI3K/AKT pathways via distinct mechanisms.	ros	45-48	thymoma viral proto-oncogene 1	Mus musculus	91-94
31285773-9	2019	Mechanistically, vitamin C eradicated BRAF wild-type thyroid cancer cells through ROS-mediated decrease in the activity of EGF/EGFR-MAPK/ERK signaling and an increase in AKT ubiquitination and degradation.	ros	82-85	mitogen-activated protein kinase 1	Mus musculus	137-140
31285773-10	2019	On the other hand, vitamin C exerted its antitumor activity in BRAF mutant thyroid cancer cells by inhibiting the activity of ATP-dependent MAPK/ERK signaling and inducing proteasome degradation of AKT via the ROS-dependent pathway.	ros	210-213	thymoma viral proto-oncogene 1	Mus musculus	198-201
31244838-4	2019	NLRP3 activation also depends on NEK7 and mitochondrial ROS-production.	ros	56-59	NLR family pyrin domain containing 3	Homo sapiens	0-5
31165168-4	2019	In human kidney proximal tubule cells (HK-2), ROS-mediated PARP-1 hyperactivation and elevations in [Ca2+]i are reciprocally coupled.	ros	46-49	poly(ADP-ribose) polymerase 1	Homo sapiens	59-65
31165168-14	2019	Therefore it is likely that ROS have an important impact on the function of TFII-I, such as regulation of transcription, and DNA translesion synthesis.	ros	28-31	general transcription factor IIi	Homo sapiens	76-82
31360100-8	2019	Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages.	ros	147-150	GLI family zinc finger 2	Homo sapiens	177-182
30767087-5	2019	ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	45-48
30767087-5	2019	ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	159-162
30767087-5	2019	ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity.	ros	120-123	AKT serine/threonine kinase 1	Homo sapiens	45-48
30767087-5	2019	ROS here played a crucial role in modulating Akt activity when autophagy process was hindered by chloroquine, excessive ROS accumulation in the cell inhibited Akt activity.	ros	120-123	AKT serine/threonine kinase 1	Homo sapiens	159-162
30965051-7	2019	Additionally, PI3K/Akt and ROS were also involved in Sulforaphane-induced Nrf2 activation and HO-1 expression, as revealed by the pharmacological inhibitors LY294002 and NAC.	ros	27-30	heme oxygenase 1	Mus musculus	94-98
31169018-11	2019	This study revealed that hypoxia-improved cisplatin chemoresistance of NSCLC cells by regulated MDR1 and MRP1 expression via HIF1alpha/ROS pathway is reversed by LW6, suggesting that LW6 may act as effective sensitizer in chemotherapy for NSCLC.	ros	135-138	ATP binding cassette subfamily B member 1	Homo sapiens	96-100
31169018-11	2019	This study revealed that hypoxia-improved cisplatin chemoresistance of NSCLC cells by regulated MDR1 and MRP1 expression via HIF1alpha/ROS pathway is reversed by LW6, suggesting that LW6 may act as effective sensitizer in chemotherapy for NSCLC.	ros	135-138	ATP binding cassette subfamily C member 1	Homo sapiens	105-109
31169018-11	2019	This study revealed that hypoxia-improved cisplatin chemoresistance of NSCLC cells by regulated MDR1 and MRP1 expression via HIF1alpha/ROS pathway is reversed by LW6, suggesting that LW6 may act as effective sensitizer in chemotherapy for NSCLC.	ros	135-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	125-134
30825187-10	2019	Diosmetin induced ROS production in NSCLC cells probably via reducing Nrf2 stability through disruption of the PI3K/Akt/GSK-3beta pathway.	ros	18-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	70-74
30991050-8	2019	Notably, silencing of Nrf2 (siRNA transfection) significantly diminished CoQ10-mediated anti-melanogenic activity, as evidenced by impaired antioxidant HO-1 gene, uncontrolled ROS generation, and alpha-MSH production following UVA irradiation.	ros	176-179	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
31083280-0	2019	NF-kappaB-Dependent Production of ROS and Restriction of HSV-1 Infection in U937 Monocytic Cells.	ros	34-37	nuclear factor kappa B subunit 1	Homo sapiens	0-9
31012036-12	2019	Furthermore, we showed that mitochondrial located TRPC3 was upregulated and modulating mitochondrial calcium uptake, thus promoting the ROS productions in the presence of PC2 knockdown.	ros	136-139	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	50-55
30370641-7	2019	In vitro, Nrf2 activation attenuated TGF-beta1-induced EMT and ROS production accompanied by the downregulation of HMGB1.	ros	63-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	10-14
30370641-8	2019	In contrast, silencing Nrf2 enhanced TGF-beta1-induced EMT and ROS production along with increased the protein expression and the release of HMGB1.	ros	63-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
30920150-7	2019	Treatment of control-VPCs with TGF-beta1 significantly enhanced mitochondrial reactive oxidative species (ROS) and induced cellular senescence whereas inhibition of ROS reversed these effects.	ros	106-109	transforming growth factor beta 1	Homo sapiens	31-40
31003152-7	2019	RESULTS: Compared to the control group, liver cells from apoE-KO presented some typical redox imbalance features: higher levels of intracellular ROS (global oxidative stress ~60%, superoxide anion ~82%, and peroxynitrite/hydroxyl radical ~53%), higher amounts of apoptotic cells (up to ~19%) and higher mitochondrial intensity of catalase (+339%) and transferrin spots (+914%).	ros	145-148	apolipoprotein E	Mus musculus	57-61
31003152-8	2019	After treatment with sildenafil, apoE-KO presented ROS levels and the number of apoptotic cells similar to those observed in C57.	ros	51-54	apolipoprotein E	Mus musculus	33-37
31191310-0	2019	Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation.	ros	110-113	NLR family, pyrin domain containing 3	Rattus norvegicus	130-135
31191310-9	2019	Collectively, TEA protects renal tubular cells against Adriamycin-induced tubule injury via inhibition of ROS-ERK1/2-NLRP3 inflammasomes.	ros	106-109	NLR family, pyrin domain containing 3	Rattus norvegicus	117-122
31191819-8	2019	ROS was implicated as being involved post-treatment with the involvement of TSPO and MPO.	ros	0-3	myeloperoxidase	Homo sapiens	85-88
31121852-7	2019	Assessment of initiation of ROS generation and cell metabolism shows significant protective effects of these two novel TSPO ligands.	ros	28-31	translocator protein	Mus musculus	119-123
31249639-0	2019	Excessive Neutrophil Extracellular Trap Formation Aggravates Acute Myocardial Infarction Injury in Apolipoprotein E Deficiency Mice via the ROS-Dependent Pathway.	ros	140-143	signal sequence receptor, delta	Mus musculus	35-39
31249639-10	2019	In such a process, apolipoprotein E regulates NET formation via the ROS-MAPK-MSK1 pathway.	ros	68-71	apolipoprotein E	Mus musculus	19-35
31223424-6	2019	After treatment with 25-50 muM NaHS, the ROS levels were decreased and the protein levels of p-PI3K, p-AKT, p-mTOR, H-RAS, p-RAF, p-MEK1/2, and p-ERK1/2 were increased, whereas 200 muM NaHS exerted opposite effects in human thyroid carcinoma cells.	ros	41-44	latexin	Homo sapiens	27-30
31223424-8	2019	In conclusion, our results demonstrate that exogenous H2S regulates the growth of human thyroid carcinoma cells through ROS/PI3K/Akt/mTOR and RAS/RAF/MEK/ERK signaling pathways.	ros	120-123	mechanistic target of rapamycin kinase	Homo sapiens	133-137
30928096-6	2019	Here, we found that H2 relaxin increased eNOS, SOD1 expression, inhibited excessive mitochondrial fission and decreased ROS level in HUVECs treated with AngII.	ros	120-123	angiotensinogen	Homo sapiens	153-158
30928096-7	2019	However, overexpression of fission protein 1 (Fis1) prevented H2 relaxin from protecting against AngII-induced low eNOS, SOD1 expression, excessive mitochondrial fission and increased ROS level in HUVECs.	ros	184-187	angiotensinogen	Homo sapiens	97-102
31081803-3	2019	We demonstrated that inositol 1,3,4,5-tetrakisphosphate (IP4), the product of ITPKB, plays a critical role in redox homeostasis upon cisplatin exposure by reducing cisplatin-induced ROS through inhibition of a ROS-generating enzyme, NADPH oxidase 4 (NOX4), which promotes cisplatin-resistant tumor growth.	ros	182-185	inositol-trisphosphate 3-kinase B	Homo sapiens	78-83
31081803-3	2019	We demonstrated that inositol 1,3,4,5-tetrakisphosphate (IP4), the product of ITPKB, plays a critical role in redox homeostasis upon cisplatin exposure by reducing cisplatin-induced ROS through inhibition of a ROS-generating enzyme, NADPH oxidase 4 (NOX4), which promotes cisplatin-resistant tumor growth.	ros	210-213	inositol-trisphosphate 3-kinase B	Homo sapiens	78-83
30835941-11	2019	Knockdown of Nrf2 significantly up-regulated the expression of pyroptosis related proteins, ROS level, caspase-1, and the TUNEL positive cells, while over-expression of Nrf2 resulted in opposite results.	ros	92-95	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
30825547-5	2019	In line with the alleviated ROS levels, tambulin treatment led to upregulated mRNA expression of ROS scavenging genes viz., sod-1, sod-3, and ctl-2.	ros	97-100	Peroxisomal catalase 1	Caenorhabditis elegans	142-147
30573782-0	2019	B7-H3 promotes multiple myeloma cell survival and proliferation by ROS-dependent activation of Src/STAT3 and c-Cbl-mediated degradation of SOCS3.	ros	67-70	signal transducer and activator of transcription 3	Mus musculus	99-104
30573782-10	2019	These data indicate B7-H3"s important role in the activation of ROS/Src/c-Cbl pathway in multiple myeloma which integrates redox regulation and sustained STAT3 activation at the level of degradation of STAT3 suppressor.	ros	64-67	signal transducer and activator of transcription 3	Mus musculus	154-159
30573782-10	2019	These data indicate B7-H3"s important role in the activation of ROS/Src/c-Cbl pathway in multiple myeloma which integrates redox regulation and sustained STAT3 activation at the level of degradation of STAT3 suppressor.	ros	64-67	signal transducer and activator of transcription 3	Mus musculus	202-207
30088174-9	2019	PLA2G6D331Y/D331Y mice displayed mitochondrial dysfunction and upregulated ROS production, which may lead to activation of apoptotic cascade.	ros	75-78	phospholipase A2, group VI	Mus musculus	0-6
30978539-0	2019	TLR4 participates in sympathetic hyperactivity Post-MI in the PVN by regulating NF-kappaB pathway and ROS production.	ros	102-105	toll-like receptor 4	Rattus norvegicus	0-4
31004990-7	2019	Consistently, FoxO4-mediated ROS generation was attenuated upon inhibition of Brd4 with JQ1 or siRNA against Brd4.	ros	29-32	forkhead box O4	Mus musculus	14-19
31004990-9	2019	In conclusion, our results proved that Brd4 inhibition blocked renal apoptotic and ERS protein expression by preventing FoxO4-dependent ROS generation through the PI3K/AKT pathway, indicating that Brd4 could be a potential therapeutic target for renal I/R injury.	ros	136-139	forkhead box O4	Mus musculus	120-125
31055911-3	2019	Following cellular uptake, PMs first release LPC to significantly elevate the reactive oxidative species (ROS) level through NAD(P)H: quinone oxidoreductase-1 (NQO1) catalysis.	ros	106-109	NAD(P)H quinone dehydrogenase 1	Homo sapiens	125-158
31055911-3	2019	Following cellular uptake, PMs first release LPC to significantly elevate the reactive oxidative species (ROS) level through NAD(P)H: quinone oxidoreductase-1 (NQO1) catalysis.	ros	106-109	NAD(P)H quinone dehydrogenase 1	Homo sapiens	160-164
31055911-4	2019	Then, NQO1-generated ROS in combination with endogenous high ROS levels in tumor cells could synergistically facilitate PTX-S-LA to release the active cytotoxic agent PTX.	ros	21-24	NAD(P)H quinone dehydrogenase 1	Homo sapiens	6-10
31239661-13	2019	The possible mechanism may be related to the Nrf-2 induction via its antioxidant mechanism to maintain the redox balance and reduction in CYP2E1 activity which can lead to ROS-mediated oxidative stress.	ros	172-175	NFE2 like bZIP transcription factor 2	Homo sapiens	45-50
31239661-13	2019	The possible mechanism may be related to the Nrf-2 induction via its antioxidant mechanism to maintain the redox balance and reduction in CYP2E1 activity which can lead to ROS-mediated oxidative stress.	ros	172-175	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	138-144
31118506-7	2019	The Ang II receptor blocker losartan and the ROS scavenger NAC restored MYH9 expression in Ang II-treated podocytes, attenuated disrupted actin cytoskeleton and decreased albumin permeability.	ros	45-48	myosin heavy chain 9	Homo sapiens	72-76
31118506-10	2019	These results suggest that Ang II-mediated MYH9 depletion in diabetic nephropathy may increase filtration barrier permeability by inducing structural and functional podocyte injury through TRPC6-mediated Ca2+ influx by NOX4-mediated ROS generation.	ros	233-236	myosin heavy chain 9	Homo sapiens	43-47
31083280-6	2019	HSV-1 infection induces an immediate ROS production in U937 monocytic cells that can efficiently activate NF-kappaB but not in DN-IkappaB-mutant cells.	ros	37-40	nuclear factor kappa B subunit 1	Homo sapiens	106-115
31083280-8	2019	Our results suggest a scenario in which an efficient NF-kappaB-dependent ROS production in response to infection could contribute in limiting HSV-1 replication in monocytes/macrophages, thus avoiding possible irreparable damage to the innate immune system of the host during HSV-1 infection.	ros	73-76	nuclear factor kappa B subunit 1	Homo sapiens	53-62
31068208-0	2019	Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis.	ros	88-91	AKT serine/threonine kinase 1	Homo sapiens	47-50
30801705-2	2019	Mitochondrial calcium uniporter (MCU) is the primary mediator of Ca2+ influx into mitochondria, manipulating cell energy metabolism, ROS production, and programmed cell death, all of which are critical for carcinogenesis.	ros	133-136	mitochondrial calcium uniporter	Homo sapiens	33-36
31063459-4	2019	We found that diabetic Drp1S600A mice exhibited improved biochemical and histological features of DN along with reduced mitochondrial fission and diminished mitochondrial ROS in vivo.	ros	171-174	dynamin 1-like	Mus musculus	23-27
30786163-5	2019	RESULTS: The results showed that 0.04 mm of ALA abrogated LPS-reduced sperm motility, viability, ROS production, spontaneous acrosome reaction, fertilizability, and developmental competence.	ros	97-100	toll-like receptor 4	Mus musculus	58-61
30763884-0	2019	Discovery of novel chalcone-dithiocarbamates as ROS-mediated apoptosis inducers by inhibiting catalase.	ros	48-51	catalase	Homo sapiens	94-102
30849338-0	2019	Indoxyl sulfate induces myotube atrophy by ROS-ERK and JNK-MAFbx cascades.	ros	43-46	mitogen-activated protein kinase 1	Mus musculus	47-50
30738928-10	2019	Under pretreatment with NADPH oxidase inhibitors, intracellular ROS generation was confirmed to participate in oxLDL/beta2GPI/anti-beta2GPI complex-induced proliferation and apoptosis, as well as the phosphorylation of NF-kappaB and MAPKs.	ros	64-67	nuclear factor kappa B subunit 1	Homo sapiens	219-228
30738928-11	2019	Taken together, our data clearly revealed that the oxLDL/beta2GPI/anti-beta2GPI complex had biphasic effects on VSMC survival, partly mediated by ROS-induced NF-kappaB and MAPKs activation.	ros	146-149	nuclear factor kappa B subunit 1	Homo sapiens	158-167
30849338-11	2019	These findings indicated that IS-mediated myotube atrophy may manipulate through ROS-ERK axis and JNK-MAFbx regulation in C2C12 cells.	ros	81-84	mitogen-activated protein kinase 1	Mus musculus	85-88
30880247-12	2019	In addition, we demonstrated how a ROS-mediated metabolism reprogramming, involving PGC-1alpha and increased mitochondrial mass, is induced during short-time cisplatin exposure.	ros	35-38	PPARG coactivator 1 alpha	Homo sapiens	84-94
30802489-4	2019	The anti-inflammatory properties of Nrf2 signaling are discussed in relation to the ROS/inflammation interplay in noise exposure.	ros	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	36-40
30920152-9	2019	In summary, our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1alpha/HK2 signalling axis, providing a potential anti-cancer strategy.	ros	118-121	AKT serine/threonine kinase 1	Homo sapiens	127-130
30920152-9	2019	In summary, our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1alpha/HK2 signalling axis, providing a potential anti-cancer strategy.	ros	118-121	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
31631596-16	2019	Decreased Keap1/Nrf2-ARE pathway inhibition and ROS clearance may also cause macrophage production of NLRP3 inflammatory bodies.	ros	48-51	NLR family, pyrin domain containing 3	Rattus norvegicus	102-107
31178951-10	2019	To further reveal the relevant mechanism, the oxidative stress-mediated PI3K/AKT/mTOR pathway was assessed, which showed that a reduced expression of p-PI3K, p-AKT, and p-mTOR in C2C12 myoblast atrophy induced by TNF-alpha could be upregulated by ATL-III; however, after the overexpression of Nox2 to increase ROS production, the attenuated effect was reversed.	ros	310-313	AKT serine/threonine kinase 1	Rattus norvegicus	77-80
31114548-3	2019	B(a)P exposure induced ROS mediated steroidogenic imbalance via activation of p38MAPK and repression of testosterone level as well as other steroidogenic enzymes like CYPIIA1, 3beta-HSD, 17beta-HSD expressions.	ros	23-26	hydroxysteroid 17-beta dehydrogenase 1	Homo sapiens	187-197
31017975-5	2019	In this study, we provide evidence that considerable levels of p62-mediated selective autophagy are spontaneously induced, and correlate with ROS-Keap1-NRF2 pathway activity, in virus-transformed cells.	ros	142-145	kelch like ECH associated protein 1	Homo sapiens	146-151
31017975-5	2019	In this study, we provide evidence that considerable levels of p62-mediated selective autophagy are spontaneously induced, and correlate with ROS-Keap1-NRF2 pathway activity, in virus-transformed cells.	ros	142-145	NFE2 like bZIP transcription factor 2	Homo sapiens	152-156
30976936-6	2019	ROS levels in EA.hy926 cells were measured after treatment with LPP-CAT.	ros	0-3	catalase	Homo sapiens	68-71
31179339-9	2019	In conclusion, BSF can decrease proteinuria and protect podocytes from injury in DN, in part through inhibiting the NOX-4/ROS/p38 pathway.	ros	122-125	mitogen-activated protein kinase 14	Homo sapiens	126-129
30976936-9	2019	LPP-CAT protected MCF-7 cells from lethal level of exogenous H2O2 and significantly lowered the ROS levels in EA.hy926 cells.	ros	96-99	catalase	Homo sapiens	4-7
30900705-0	2019	DNA supersandwich assemblies as artificial receptors to mediate intracellular delivery of catalase for efficient ROS scavenging.	ros	113-116	catalase	Homo sapiens	90-98
30959886-5	2019	It was identified that molecular action of vitamin D is involved in maintaining the normal resting levels of ROS and Ca2+, not only in pancreatic beta-cells, but also in insulin responsive tissues.	ros	109-112	insulin	Homo sapiens	170-177
30660647-2	2019	This study aimed to evaluate the apoptotic action of CBD in colorectal cancer (CRC) cells, and focused on its effects on the novel pro-apoptotic Noxa-reactive oxygen species (ROS) signaling pathway.	ros	175-178	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	145-149
30660647-6	2019	After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents.	ros	6-9	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	47-51
30660647-6	2019	After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents.	ros	6-9	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	121-125
30660647-6	2019	After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents.	ros	84-87	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	47-51
30660647-6	2019	After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents.	ros	84-87	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	121-125
30660647-6	2019	After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents.	ros	84-87	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	47-51
30660647-6	2019	After ROS production was blocked, the level of Noxa also decreased, suggesting that ROS is involved in the regulation of Noxa, which along with ROS is a well-known pro-apoptotic signaling agents.	ros	84-87	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	121-125
30900705-2	2019	The catalase transfection led to inhibition of intracellular ROS, while the cell viability was also remarkably improved even when exposed to H2O2 and lipopolysaccharide environments.	ros	61-64	catalase	Homo sapiens	4-12
30324853-3	2019	Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs.	ros	23-26	interleukin 4	Homo sapiens	173-176
30986945-6	2019	Overexpression of those miRNAs resulted in downregulation of Nrf2 expression resulted in higher ROS accumulation, reduced mitochondrial activity and cellular proliferation.	ros	96-99	NFE2 like bZIP transcription factor 2	Bos taurus	61-65
30324853-7	2019	ROS decrease correlated also with the reduction of mitochondria, the main source of intracellular ROS, achieved by the downregulation of NRF1 and TFAM, mitochondrial biogenesis transcription factors.	ros	0-3	transcription factor A, mitochondrial	Homo sapiens	146-150
30324853-7	2019	ROS decrease correlated also with the reduction of mitochondria, the main source of intracellular ROS, achieved by the downregulation of NRF1 and TFAM, mitochondrial biogenesis transcription factors.	ros	98-101	transcription factor A, mitochondrial	Homo sapiens	146-150
30414389-0	2019	Non-mitotic effect of albendazole triggers apoptosis of human leukemia cells via SIRT3/ROS/p38 MAPK/TTP axis-mediated TNF-alpha upregulation.	ros	87-90	tumor necrosis factor	Homo sapiens	118-127
30703374-0	2019	Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFbeta1/Smad2/3 signaling axis.	ros	90-93	SMAD family member 2	Mus musculus	104-111
30414389-5	2019	ABZ-induced SIRT3 degradation elicited ROS-mediated p38 MAPK activation, leading to pyruvate kinase M2-mediated tristetraprolin (TTP) degradation.	ros	39-42	sirtuin 3	Homo sapiens	12-17
30414389-5	2019	ABZ-induced SIRT3 degradation elicited ROS-mediated p38 MAPK activation, leading to pyruvate kinase M2-mediated tristetraprolin (TTP) degradation.	ros	39-42	mitogen-activated protein kinase 14	Homo sapiens	52-55
30414389-7	2019	Either the overexpression of SIRT3 or abolishment of ROS/p38 MAPK activation suppressed TNF-alpha upregulation and rescued the viability of ABZ-treated cells.	ros	53-56	tumor necrosis factor	Homo sapiens	88-97
30703374-4	2019	Mechanistically, angiotensin II induced robust ROS generation, which in turn triggered activation of pro-fibrotic TGFbeta1-Smad2/3 signaling and subsequent collagen synthesis and fibroblast-myofibroblast transformation in cardiac fibroblasts.	ros	47-50	SMAD family member 2	Mus musculus	123-130
30703374-0	2019	Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFbeta1/Smad2/3 signaling axis.	ros	90-93	nuclear factor, erythroid derived 2, like 2	Mus musculus	62-66
30703377-0	2019	Cell-specific regulation of Nrf2 during ROS-Dependent cell death caused by 2,3,5-tris(glutathion-S-yl)hydroquinone (TGHQ).	ros	40-43	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
30703377-3	2019	Herein, we sought to determine the nature of the Nrf2 regulation in HK-2 and HL-60 cells undergoing TGHQ-mediated ROS-dependent cell death, due to the key role of Nrf2 in oxidative stress.	ros	114-117	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
30831213-3	2019	In this study, we showed that HT-2 treatment disrupted mouse early embryo development, and we also found the occurrence of oxidative stress, showing with the increased ROS level.	ros	168-171	hypothermia due to alcohol sensitivity 2	Mus musculus	30-34
30936322-0	2019	Withdrawal: 12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction.	ros	41-44	arachidonate 15-lipoxygenase	Homo sapiens	15-30
30051353-9	2019	Mechanistic studies revealed that increase in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (NOX2)-dependent superoxide/reactive oxygen species (ROS) production plays a key role in both LPS- and DSP-4-elicited neurotoxicity.	ros	161-164	toll-like receptor 4	Mus musculus	202-205
30934859-6	2019	Basal ROS levels are elevated in pmr1  yeast and artemisinin exposure does not enhance ROS accumulation.	ros	6-9	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	33-37
30826469-4	2019	Moreover, Nrf2 translocation appeared both in GD 12.5 d and GD 18.5 d. In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage.	ros	98-101	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
30826469-4	2019	Moreover, Nrf2 translocation appeared both in GD 12.5 d and GD 18.5 d. In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage.	ros	243-246	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
30826469-4	2019	Moreover, Nrf2 translocation appeared both in GD 12.5 d and GD 18.5 d. In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage.	ros	243-246	NFE2 like bZIP transcription factor 2	Homo sapiens	201-205
30784083-9	2019	A hybrid gene (GYPB-E-B.Ros) was found in one sample after discrepant results in the initial tests.	ros	24-27	glycophorin B (MNS blood group)	Homo sapiens	15-19
30934859-8	2019	Yeast deleted for PMR1 are known to accumulate excess manganese ions that can function as ROS-scavenging molecules, but no correlation between manganese content and artemisinin resistance was observed.	ros	90-93	Ca(2+)/Mn(2+)-transporting P-type ATPase PMR1	Saccharomyces cerevisiae S288C	18-22
30914692-10	2019	In conclusion, Ang II-induced oxidative stress was augmented by high glucose levels and ROS levels were further alleviated in the presence of AT1R antagonists.	ros	88-91	angiotensinogen	Homo sapiens	15-21
30914692-6	2019	Ang II-induced elevated intracellular ROS levels were detected only when the cells were pre-incubated with high levels of glucose (13.5 mM, 27.8 mM), but was not detected under normal glucose condition (5.5 mM).	ros	38-41	angiotensinogen	Homo sapiens	0-6
30909929-10	2019	Inhibition of ROS production, mitochondrial Ca2+ uptake, Nrf2 expression or Notch1 activity significantly suppressed MCUR1-induced EMT of HCC cells.	ros	14-17	mitochondrial calcium uniporter regulator 1	Homo sapiens	117-122
30909929-0	2019	MCUR1 facilitates epithelial-mesenchymal transition and metastasis via the mitochondrial calcium dependent ROS/Nrf2/Notch pathway in hepatocellular carcinoma.	ros	107-110	mitochondrial calcium uniporter regulator 1	Homo sapiens	0-5
30909929-6	2019	The underlying mechanism has also been explored by investigating the effect of MCUR1 on ROS/Nrf2/Notch1 pathway.	ros	88-91	mitochondrial calcium uniporter regulator 1	Homo sapiens	79-84
30909929-9	2019	Mechanistically, MCUR1-mediated mitochondrial Ca2+ signaling promoted the EMT of HCC cells by activating ROS/Nrf2/Notch1 pathway.	ros	105-108	mitochondrial calcium uniporter regulator 1	Homo sapiens	17-22
30909929-11	2019	In addition, treatment with the mitochondrial Ca2+-buffering protein parvalbumin significantly inhibited ROS/Nrf2/Notch pathway and MCUR1-induced EMT and HCC metastasis.	ros	105-108	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
30914692-7	2019	Production of Ang II-induced intracellular ROS was higher under pre-treatment with 27.8 mM glucose compared to pretreatment with 13.5 mM glucose level.	ros	43-46	angiotensinogen	Homo sapiens	14-20
30659826-9	2019	Based on the observations, we conclude that MLB is able to prevent phenotypic transformation of pulmonary arteries in hypoxic PAH rats through suppression of NOX/ROS/ERK pathway, and MLB might have the potentials in PAH therapy.	ros	162-165	Eph receptor B1	Rattus norvegicus	166-169
30914692-8	2019	This ROS production in mesangial cells was induced within several minutes of the initiation of Ang II stimulation under high glucose levels.	ros	5-8	angiotensinogen	Homo sapiens	95-101
30874538-8	2019	It seems that beta-Thujaplicin exerts these functions by ROS-mediated p38/ERK MAPK but not by JNK signaling pathway activation.	ros	57-60	mitogen-activated protein kinase 14	Homo sapiens	70-73
30874538-8	2019	It seems that beta-Thujaplicin exerts these functions by ROS-mediated p38/ERK MAPK but not by JNK signaling pathway activation.	ros	57-60	mitogen-activated protein kinase 1	Homo sapiens	74-77
30827109-2	2019	In this work, platinized carbon nanoelectrodes were used to detect, characterize, and quantify for the first time the intracellular production rates of the four primary ROS/RNS (i.e., H2O2, ONOO-, NO , and NO2-) inside single phagolysosomes of living RAW 264.7 murine macrophages stimulated by interferon-gamma and lipopolysaccharide (IFN-gamma/LPS) to mimic an in vivo inflammatory activation.	ros	169-172	interferon gamma	Mus musculus	294-310
30827109-2	2019	In this work, platinized carbon nanoelectrodes were used to detect, characterize, and quantify for the first time the intracellular production rates of the four primary ROS/RNS (i.e., H2O2, ONOO-, NO , and NO2-) inside single phagolysosomes of living RAW 264.7 murine macrophages stimulated by interferon-gamma and lipopolysaccharide (IFN-gamma/LPS) to mimic an in vivo inflammatory activation.	ros	169-172	interferon gamma	Mus musculus	335-344
30909993-5	2019	Clinical factors such as age, gender, histology, pleural effusion and gene mutations with epidermal growth factor receptor/anaplastic lymphoma kinase/ROS proto-oncogene 1 receptor tyrosine kinase (EGFR/ALK/ROS1) were analyzed.	ros	150-153	epidermal growth factor receptor	Homo sapiens	197-201
30874538-0	2019	beta-Thujaplicin induces autophagic cell death, apoptosis, and cell cycle arrest through ROS-mediated Akt and p38/ERK MAPK signaling in human hepatocellular carcinoma.	ros	89-92	AKT serine/threonine kinase 1	Homo sapiens	102-105
30874538-5	2019	Further using beta-Thujaplicin combined with an autophagy blocker or agonist treatment HepG2 cells, we found that beta-Thujaplicin induced autophagic cell death (ACD) mediated by ROS caused inhibition of the Akt-mTOR signaling pathway.	ros	179-182	AKT serine/threonine kinase 1	Homo sapiens	208-211
30887719-11	2019	HBx inhibits the expression of HMGB1 and the generation of ROS via the NF-kappaB signaling pathway.	ros	59-62	nuclear factor kappa B subunit 1	Homo sapiens	71-80
30579254-8	2019	Molecular investigations demonstrated that INF2 deletion attenuated mitochondrial ROS overloading, restored the cellular redox balance, sustained the mitochondrial membrane potential, improved mitochondrial respiratory function and corrected the mitochondrial dynamics disorder in an H2O2-mimicking oxidative stress microenvironment.	ros	82-85	inverted formin 2	Homo sapiens	43-47
29911259-5	2019	Intercellular signals induce production of free radicals and inflammatory mediators by some intermediate enzymes such as cyclooxygenase-2 (COX-2), nitric oxide synthase (NOS), NADPH oxidase, and also via triggering mitochondrial ROS.	ros	229-232	prostaglandin-endoperoxide synthase 2	Homo sapiens	139-144
30850580-6	2019	Human colon cancer cells silenced for myoferlin exhibit a reduced oxidative phosphorylation activity associated with mitochondrial fission leading, ROS accumulation, decreased cell growth, and increased apoptosis.	ros	148-151	myoferlin	Homo sapiens	38-47
30895171-1	2019	Prima-1Met (APR-246) was previously shown to be dependent on glutathione inhibition and on ROS induction in cancer cells with mutated or deleted TP53.	ros	91-94	tumor protein p53	Homo sapiens	145-149
30948926-0	2019	Cx43 Inhibition Attenuates Sepsis-Induced Intestinal Injury via Downregulating ROS Transfer and the Activation of the JNK1/Sirt1/FoxO3a Signaling Pathway.	ros	79-82	gap junction protein, alpha 1	Rattus norvegicus	0-4
30948926-5	2019	Secondly, the influence of ROS content on the activity of the JNK1/Sirt1/FoxO3a signaling pathway was explored through the application of NAC, sp600125 (a JNK1 inhibitor), and nicotinamide (a Sirt1 inhibitor).	ros	27-30	sirtuin 1	Rattus norvegicus	67-72
30948926-9	2019	The changes of Cx43 channel function regulated ROS transfer between the neighboring cells, which mediated the activation of the JNK1/Sirt1/FoxO3a signaling pathway.	ros	47-50	gap junction protein, alpha 1	Rattus norvegicus	15-19
30948926-9	2019	The changes of Cx43 channel function regulated ROS transfer between the neighboring cells, which mediated the activation of the JNK1/Sirt1/FoxO3a signaling pathway.	ros	47-50	sirtuin 1	Rattus norvegicus	133-138
30948926-11	2019	In summary, our results suggest that Cx43 inhibition suppresses ROS transfer and inactivates the JNK1/Sirt1/FoxO3a signaling pathway to protect against sepsis-induced intestinal injury.	ros	64-67	gap junction protein, alpha 1	Rattus norvegicus	37-41
30584985-7	2019	The parasite elimination was associated with generation of ROS and NO that are interrelated with up-regulation of disease-suppressing Th1 cytokines and down-regulation of disease-promoting Th2 cytokines at both protein and mRNA level.	ros	59-62	negative elongation factor complex member C/D, Th1l	Mus musculus	134-137
30453174-5	2019	In rat kidney tubular epithelial cells (NRK52E), ROS production increased expression levels of TGF-beta1 and subsequently contributed to the induction of Snail1-mediated EMT.	ros	49-52	transforming growth factor, beta 1	Rattus norvegicus	95-104
30597356-9	2019	Galangin also reversed the decreased expression of claudin1 and occludin, and the increased BRB injury and ROS formation in TNFalpha-treated human retinal endothelial cells (HRECs) and ARPE19 cells.	ros	107-110	tumor necrosis factor	Homo sapiens	124-132
30710830-4	2019	Cyclooxygenase-2 (COX-2), as an inflammatory mediator is associated with ROS production with a NF-kappaB gene up regulation dependent manner in normal tissues.	ros	73-76	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
30365183-10	2019	Thus, Cygb restoration could be a novel and promising therapeutic strategy against HCC with aberrant ROS/RNS accumulation.	ros	101-104	cytoglobin	Homo sapiens	6-10
30778058-4	2019	Mechanistically, miR-135 accumulates specifically in response to glutamine deprivation and requires ROS-dependent activation of mutant p53, which directly promotes miR-135 expression.	ros	100-103	tumor protein p53	Homo sapiens	135-138
30814492-0	2019	Author Correction: Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB.	ros	130-133	GLI family zinc finger 2	Homo sapiens	100-105
30707992-8	2019	Mechanistically, MTG1 preserved mitochondrial respiratory chain complex activity during pressure overload, which further attenuated ROS generation.	ros	132-135	mitochondrial ribosome-associated GTPase 1	Mus musculus	17-21
30448556-0	2019	Overexpression of HIF-1a could partially protect K562 cells from 1,4-benzoquinone induced toxicity by inhibiting ROS, apoptosis and enhancing glycolysis.	ros	113-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-24
30448556-6	2019	Compared with 1,4-BQ exposed control cells, HIF-1a overexpression blocked cell cycle at G2/M phase, remarkably reduced apoptosis and ROS level.	ros	133-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	44-50
30448556-10	2019	Overall, our results indicated that HIF-1a overexpression could alleviate ROS and apoptosis caused by 1,4-BQ through targeting Nox4, Bcl-2 and key enzymes in glycolysis.	ros	74-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-42
30816299-1	2019	24 h exposure to 4  C primes Arabidopsis thaliana in the pre-bolting rosette stage for several days against full cold activation of the ROS responsive genes ZAT10 and BAP1 and causes stronger cold-induction of pleiotropically stress-regulated genes.	ros	136-139	salt tolerance zinc finger	Arabidopsis thaliana	157-162
30779746-0	2019	IL-11 prevents IFN-gamma-induced hepatocyte death through selective downregulation of IFN-gamma/STAT1 signaling and ROS scavenging.	ros	116-119	interferon gamma	Mus musculus	15-24
30779746-12	2019	CONCLUSION: IL-11 protects hepatocytes from IFN-gamma-induced death via STAT1 signal suppression and ROS scavenging.	ros	101-104	interferon gamma	Mus musculus	44-53
30391442-0	2019	MiR-375 induces ROS and apoptosis in ST cells by targeting the HIGD1A gene.	ros	16-19	microRNA 375	Homo sapiens	0-7
30911553-13	2019	In conclusion, LPS could increase the sensitivity of H9C2 cells to HG and H/R and aggravated HG- and H/R-induced H9C2 cell injury by promoting ROS production to induce NLRP3 inflammasome-mediated pyroptosis.	ros	143-146	NLR family, pyrin domain containing 3	Rattus norvegicus	168-173
30911355-0	2019	The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network.	ros	101-104	superoxide dismutase 1	Homo sapiens	27-31
30911355-2	2019	Here, tests performed by the utilization of our designed specific SOD1 inhibitor LD100 on cancer and normal cells reveal that the signaling pathways and their crosstalk to support cancer cell growth are repressed, but the signaling pathways to promote cancer cell cycle arrest and apoptosis are stimulated by specific SOD1 inhibition-mediated ROS changes.	ros	343-346	superoxide dismutase 1	Homo sapiens	66-70
30911355-4	2019	This ROS signaling network is also regulated in SOD1 knockdown cells.	ros	5-8	superoxide dismutase 1	Homo sapiens	48-52
30911553-0	2019	Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes.	ros	110-113	NLR family, pyrin domain containing 3	Rattus norvegicus	124-129
30391442-5	2019	However, ROS levels and CASPASE3 expression in miR-375-overexpressing cells were significantly higher than those in the control cells.	ros	9-12	microRNA 375	Homo sapiens	47-54
30391442-7	2019	Considering that the HIGD1A gene is a target of miR-375, these findings suggest that miR-375 can induce an increase in ROS levels and apoptosis by inhibiting HIGD1A in porcine ST cells.	ros	119-122	microRNA 375	Homo sapiens	48-55
30391442-7	2019	Considering that the HIGD1A gene is a target of miR-375, these findings suggest that miR-375 can induce an increase in ROS levels and apoptosis by inhibiting HIGD1A in porcine ST cells.	ros	119-122	microRNA 375	Homo sapiens	85-92
30463122-4	2019	However, Cipro accelerated germination by promoting ROS accumulation in seeds, while the stimulatory effect of Roundup on ROS-scavenging enzymes (catalase and ascorbate peroxidase) seems to prevent ROS-signaling, delaying the germination process.	ros	122-125	peroxidase 1	Zea mays	169-179
30463122-4	2019	However, Cipro accelerated germination by promoting ROS accumulation in seeds, while the stimulatory effect of Roundup on ROS-scavenging enzymes (catalase and ascorbate peroxidase) seems to prevent ROS-signaling, delaying the germination process.	ros	122-125	peroxidase 1	Zea mays	169-179
30736789-13	2019	HO-1 expression by STL or STB resulted from Nrf2 activation through ROS-dependent p38 activation.	ros	68-71	NFE2 like bZIP transcription factor 2	Homo sapiens	44-48
30736789-14	2019	CONCLUSIONS: These results indicate that STL or STB may induce GSK3beta-dependent cyclin D1 degradation, and increase HO-1 expression through activating Nrf2 via ROS-dependent p38 activation, which resulted in the decrease of the viability in SW480 cells.	ros	162-165	NFE2 like bZIP transcription factor 2	Homo sapiens	153-157
30736789-13	2019	HO-1 expression by STL or STB resulted from Nrf2 activation through ROS-dependent p38 activation.	ros	68-71	mitogen-activated protein kinase 14	Homo sapiens	82-85
30736789-14	2019	CONCLUSIONS: These results indicate that STL or STB may induce GSK3beta-dependent cyclin D1 degradation, and increase HO-1 expression through activating Nrf2 via ROS-dependent p38 activation, which resulted in the decrease of the viability in SW480 cells.	ros	162-165	mitogen-activated protein kinase 14	Homo sapiens	176-179
30726742-7	2019	beta2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1beta production, which promotes ILC3-derived IL-22.	ros	75-78	interleukin 1 beta	Mus musculus	230-238
30711933-2	2019	Nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) and Park7 (DJ-1) are the main regulators of antioxidant enzymes eliminating reactive oxidative species (ROS).	ros	198-201	NFE2 like bZIP transcription factor 2	Homo sapiens	0-41
30804791-2	2018	Ang II can regulate proliferation, migration, ROS production and hypertrophy of vascular smooth muscle cells (VSMCs).	ros	46-49	angiotensinogen	Rattus norvegicus	0-6
30711933-2	2019	Nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) and Park7 (DJ-1) are the main regulators of antioxidant enzymes eliminating reactive oxidative species (ROS).	ros	198-201	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
30711933-2	2019	Nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) and Park7 (DJ-1) are the main regulators of antioxidant enzymes eliminating reactive oxidative species (ROS).	ros	198-201	kelch like ECH associated protein 1	Homo sapiens	50-85
30711933-2	2019	Nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) and Park7 (DJ-1) are the main regulators of antioxidant enzymes eliminating reactive oxidative species (ROS).	ros	198-201	kelch like ECH associated protein 1	Homo sapiens	87-92
30549180-9	2019	TGF-beta1-induced excessive ROS production was remarkably reversed by FKA treatment in A7r5 cells, and inhibition by FKA or N-acetylcysteine (NAC) substantially diminished TGF-beta1-induced p-Smad3 activation and wound-healing migration.	ros	28-31	transforming growth factor, beta 1	Rattus norvegicus	0-9
30476722-8	2019	At the molecular levels, the combination of IL-2 and sorafenib impaired mitochondrial respiratory function, reduced mitochondrial potential, promoted mitochondrial ROS overloading and activated mitochondrial apoptotic pathway.	ros	164-167	interleukin 2	Homo sapiens	44-48
30447254-3	2019	This is mediated by a ROS-independent activation of the MAP kinase JNK.	ros	22-25	mitogen-activated protein kinase 8	Homo sapiens	67-70
30400061-2	2019	This tumor suppression system is based upon the kill switch being triggered in cells in which p53 has been inactivated; such kill switch consisting of a rapid, catastrophic increase in ROS caused by the induction of irreversible uncompetitive inhibition of glucose-6- phosphate dehydrogenase (G6PD), which requires high concentrations of both inhibitor (DHEA) and G6P substrate.	ros	185-188	tumor protein p53	Homo sapiens	94-97
30566262-6	2019	Expression of cytokines (TLSP, IL-25 and IL-33) and the generation of ROS from keratinocytes induced by TNF-alpha were significantly inhibited by boehmite without affecting cell viability.	ros	70-73	tumor necrosis factor	Mus musculus	104-113
30557609-5	2019	Mechanistically, DHA induced autophagy by regulating the activity of AMPK/mTOR/p70S6k signaling pathway, which accelerated the degradation of ferritin, increased the labile iron pool, promoted the accumulation of cellular ROS and eventually led to ferroptotic cell death.	ros	222-225	mechanistic target of rapamycin kinase	Homo sapiens	74-78
30480549-3	2019	ASMase-mediated microcirculatory vasoconstriction after SDRT conferred an ischemic stress response within parenchymal tumor cells, with ROS triggering the evolutionarily conserved SUMO stress response, specifically depleting chromatin-associated free SUMO3.	ros	136-139	sphingomyelin phosphodiesterase 1	Homo sapiens	0-6
30840297-15	2019	DJ-1 overexpression apparently down-regulated PTEN expression, elevated p-AKT level, and attenuated apoptosis and ROS production in H9C2 cells (p<0.05).	ros	114-117	Parkinsonism associated deglycase	Rattus norvegicus	0-4
30840297-17	2019	Over-expression of DJ-1 can reduce myocardial cell I-R damage sensitivity by inhibiting PTEN expression, enhancing the activity of PI3K/AKT signaling pathway, reducing ROS production, and alleviating apoptosis.	ros	168-171	Parkinsonism associated deglycase	Rattus norvegicus	19-23
30500419-8	2019	In addition to intracellular-accumulation, we found that CSE also induces membrane-ceramide-accumulation by ROS-dependent acid-sphingomyelinase (ASM) activation and plasma-membrane translocation, which was significantly controlled (p < 0.05) by cysteamine (an anti-oxidant) and amitriptyline (AMT, an inhibitor of ASM).	ros	108-111	sphingomyelin phosphodiesterase 1	Homo sapiens	122-143
30500419-8	2019	In addition to intracellular-accumulation, we found that CSE also induces membrane-ceramide-accumulation by ROS-dependent acid-sphingomyelinase (ASM) activation and plasma-membrane translocation, which was significantly controlled (p < 0.05) by cysteamine (an anti-oxidant) and amitriptyline (AMT, an inhibitor of ASM).	ros	108-111	sphingomyelin phosphodiesterase 1	Homo sapiens	145-148
30500419-8	2019	In addition to intracellular-accumulation, we found that CSE also induces membrane-ceramide-accumulation by ROS-dependent acid-sphingomyelinase (ASM) activation and plasma-membrane translocation, which was significantly controlled (p < 0.05) by cysteamine (an anti-oxidant) and amitriptyline (AMT, an inhibitor of ASM).	ros	108-111	sphingomyelin phosphodiesterase 1	Homo sapiens	314-317
30549180-12	2019	Notably, silencing of Nrf2 (siRNA transfection) significantly diminished the FKA-mediated antioxidant effects, indicating that FKA may inhibit TGF-beta1-induced fibrosis through suppressing ROS generation in A7r5 cells.	ros	190-193	NFE2 like bZIP transcription factor 2	Rattus norvegicus	22-26
30549180-12	2019	Notably, silencing of Nrf2 (siRNA transfection) significantly diminished the FKA-mediated antioxidant effects, indicating that FKA may inhibit TGF-beta1-induced fibrosis through suppressing ROS generation in A7r5 cells.	ros	190-193	transforming growth factor, beta 1	Rattus norvegicus	143-152
30653379-9	2019	We also observed an increase in the oxidative stress response (ROS) and autophagy, and the results suggest that ROS induced autophagy by the ROS-NRF2-P62 pathway.	ros	63-66	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
30554313-6	2019	Thus, it is possible to suggest that C-PC modulates the expression of COX2 and ABCB1 for the K562-Lucena in a ROS-dependent manner and the expression of ALOX5 for the FEPS in a ROS-independent manner; however, more studies are needed to elucidate these mechanisms.	ros	110-113	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	70-74
30554313-6	2019	Thus, it is possible to suggest that C-PC modulates the expression of COX2 and ABCB1 for the K562-Lucena in a ROS-dependent manner and the expression of ALOX5 for the FEPS in a ROS-independent manner; however, more studies are needed to elucidate these mechanisms.	ros	110-113	ATP binding cassette subfamily B member 1	Homo sapiens	79-84
30554313-6	2019	Thus, it is possible to suggest that C-PC modulates the expression of COX2 and ABCB1 for the K562-Lucena in a ROS-dependent manner and the expression of ALOX5 for the FEPS in a ROS-independent manner; however, more studies are needed to elucidate these mechanisms.	ros	177-180	arachidonate 5-lipoxygenase	Homo sapiens	153-158
30653379-9	2019	We also observed an increase in the oxidative stress response (ROS) and autophagy, and the results suggest that ROS induced autophagy by the ROS-NRF2-P62 pathway.	ros	112-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
30653379-9	2019	We also observed an increase in the oxidative stress response (ROS) and autophagy, and the results suggest that ROS induced autophagy by the ROS-NRF2-P62 pathway.	ros	112-115	nuclear factor, erythroid derived 2, like 2	Mus musculus	145-149
30342220-7	2019	Together, inhibitions of PI3K/Akt and ERK and activation of p38 mediated the compounds-induced apoptosis through modulating the mitochondrial pathway and/or ROS production.	ros	157-160	AKT serine/threonine kinase 1	Homo sapiens	30-33
30611121-0	2019	Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.	ros	20-23	NLR family pyrin domain containing 3	Homo sapiens	24-29
30611121-0	2019	Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.	ros	20-23	interleukin 1 beta	Homo sapiens	30-38
30611121-0	2019	Calcitriol inhibits ROS-NLRP3-IL-1beta signaling axis via activation of Nrf2-antioxidant signaling in hyperosmotic stress stimulated human corneal epithelial cells.	ros	20-23	NFE2 like bZIP transcription factor 2	Homo sapiens	72-76
30611121-1	2019	PURPOSE: The activation of ROS-NLRP3-IL-1beta signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis.	ros	27-30	NLR family pyrin domain containing 3	Homo sapiens	31-36
30611121-1	2019	PURPOSE: The activation of ROS-NLRP3-IL-1beta signaling axis induced by hyperosmotic stress (HS) has been recognized as a key priming stage of epithelial inflammation in dry eye pathogenesis.	ros	27-30	interleukin 1 beta	Homo sapiens	37-45
30611121-8	2019	RESULTS: Calcitriol could protect cells against HS-induced injury through inhibiting ROS-NLRP3-IL-1beta signaling axis.	ros	85-88	NLR family pyrin domain containing 3	Homo sapiens	89-94
30611121-8	2019	RESULTS: Calcitriol could protect cells against HS-induced injury through inhibiting ROS-NLRP3-IL-1beta signaling axis.	ros	85-88	interleukin 1 beta	Homo sapiens	95-103
30584981-0	2019	Particulate matter induces inflammatory cytokine production via activation of NFkappaB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin.	ros	100-103	nuclear factor kappa B subunit 1	Homo sapiens	78-86
30502353-4	2019	Our findings indicate that JWH-122 and UR-144 (0.01-25 muM) induce prompt ROS/RNS formation and endoplasmic reticulum (ER) stress without reduction in cell viability.	ros	74-77	latexin	Homo sapiens	55-58
30342220-7	2019	Together, inhibitions of PI3K/Akt and ERK and activation of p38 mediated the compounds-induced apoptosis through modulating the mitochondrial pathway and/or ROS production.	ros	157-160	mitogen-activated protein kinase 1	Homo sapiens	38-41
30342220-7	2019	Together, inhibitions of PI3K/Akt and ERK and activation of p38 mediated the compounds-induced apoptosis through modulating the mitochondrial pathway and/or ROS production.	ros	157-160	mitogen-activated protein kinase 14	Homo sapiens	60-63
30580996-11	2019	Importantly, inhibiting Nrf-2 expression abolished Tmem126b knockdown-alleviated lipid deposition, apoptosis, inflammation, ROS generation and mitochondrial dysfunction.	ros	124-127	nuclear factor, erythroid derived 2, like 2	Mus musculus	24-29
30693003-9	2018	IL-17 and/or TNFalpha increased the level of the ER stress marker Grp78, mitochondrial ROS and promoted SOCE activation by 2-fold (p < 0.01) in isolated myoblasts.	ros	87-90	tumor necrosis factor	Homo sapiens	13-21
30678338-4	2019	There is evidence of CM544 selective binding to the iNOS, an event that triggers the accumulation of ROS/RNS, the expression of Nrf-2 and the phosphorylation of MAPKs after 3 h of treatment.	ros	101-104	nitric oxide synthase 2	Rattus norvegicus	52-56
30554656-0	2019	Cyclophilin D deficiency protects against the development of mitochondrial ROS and cellular inflammation in aorta.	ros	75-78	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	0-13
30554656-2	2019	Mitochondrial cyclophilin D (CypD), the important modulator for mPTP opening, is increasingly recognized as a key regulator of cellular ROS generation.	ros	136-139	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	14-27
30554656-2	2019	Mitochondrial cyclophilin D (CypD), the important modulator for mPTP opening, is increasingly recognized as a key regulator of cellular ROS generation.	ros	136-139	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	29-33
30718954-13	2019	The PSDT mediated by TOI_HNPs induced generation of intracellular ROS and downregulated the expression of HIF-1alpha and IL-6 in SKOV3 cells.	ros	66-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	106-116
30718954-13	2019	The PSDT mediated by TOI_HNPs induced generation of intracellular ROS and downregulated the expression of HIF-1alpha and IL-6 in SKOV3 cells.	ros	66-69	interleukin 6	Homo sapiens	121-125
30408749-4	2019	Preliminary anti-oxidant mechanism studies showed that compound 6e could diminish the ROS accumulation by dose- and time-dependently activating Nrf2 and increasing the expression of downstream detoxification enzymes NQO-1, HO-1, GCLM and GCLC at protein and mRNA levels, thus displaying potent anti-oxidant activity.	ros	86-89	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
30696468-10	2019	Overexpression of AK4 exaggerates HIF-1alpha protein expression by increasing intracellular ROS levels and subsequently induces EMT under hypoxia.	ros	92-95	hypoxia inducible factor 1 subunit alpha	Homo sapiens	34-44
30596504-4	2019	Here, we explore the binding of Ni(II), Hg(II), and Pb(II) to Ros87, the DNA binding domain of the prokaryotic zinc finger protein Ros.	ros	62-65	submaxillary gland androgen regulated protein 3B	Homo sapiens	52-58
32254552-7	2019	We showed that the nanohybrids possessed good colloidal stability and enabled significant inhibition of cancer cells due to the presence of TPGS, which can inhibit P-glycoprotein (P-gp) by decreasing ATP levels and increasing ROS levels; simultaneously, fluorescence imaging of cancer cells could be achieved in vitro due to the luminescence of CDs.	ros	226-229	ATP binding cassette subfamily B member 1	Homo sapiens	180-184
30693272-8	2018	This is the first time that the potential mechanism for aspirin-mediated VEGF suppression and anti-tumor effect has been discovered, and this study provides a new strategy for anti-tumor drug development for NKTCL treatment based on aspirin-mediated targeting of the VEGF signaling pathway and ROS formation.	ros	294-297	vascular endothelial growth factor A	Homo sapiens	73-77
30693272-8	2018	This is the first time that the potential mechanism for aspirin-mediated VEGF suppression and anti-tumor effect has been discovered, and this study provides a new strategy for anti-tumor drug development for NKTCL treatment based on aspirin-mediated targeting of the VEGF signaling pathway and ROS formation.	ros	294-297	vascular endothelial growth factor A	Homo sapiens	267-271
30625987-0	2019	HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS.	ros	164-167	tumor necrosis factor	Homo sapiens	27-30
30629695-0	2019	Retraction: Human Phosphatidylethanolamine-Binding Protein 4 Promoted the Radioresistance of Human Rectal Cancer by Activating Akt in an ROS-Dependent Way.	ros	137-140	phosphatidylethanolamine binding protein 4	Homo sapiens	18-60
30629695-0	2019	Retraction: Human Phosphatidylethanolamine-Binding Protein 4 Promoted the Radioresistance of Human Rectal Cancer by Activating Akt in an ROS-Dependent Way.	ros	137-140	AKT serine/threonine kinase 1	Homo sapiens	127-130
30671057-9	2018	Furthermore, anti-VEGF therapy downregulates NETs production indicating that NADPH oxidase-derived ROS may be another signaling pathway involved in anti-VEGF therapy.	ros	99-102	vascular endothelial growth factor A	Homo sapiens	18-22
30671057-9	2018	Furthermore, anti-VEGF therapy downregulates NETs production indicating that NADPH oxidase-derived ROS may be another signaling pathway involved in anti-VEGF therapy.	ros	99-102	vascular endothelial growth factor A	Homo sapiens	153-157
30625987-0	2019	HPV-Mediated Resistance to TNF and TRAIL Is Characterized by Global Alterations in Apoptosis Regulatory Factors, Dysregulation of Death Receptors, and Induction of ROS/RNS.	ros	164-167	TNF superfamily member 10	Homo sapiens	35-40
30571927-9	2019	One was from ROS-dependent activation of ATM via AMPK-ULK1-ATG13-Beclin1/ATG5.	ros	13-16	autophagy related 5	Homo sapiens	73-77
31776986-4	2019	This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways.	ros	27-30	AKT serine/threonine kinase 1	Homo sapiens	77-80
31776986-4	2019	This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways.	ros	27-30	mitogen-activated protein kinase 8	Homo sapiens	88-91
31776986-4	2019	This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways.	ros	27-30	mitogen-activated protein kinase 1	Homo sapiens	93-96
30834779-10	2019	ST-L and ST-B dramatically induced nuclear accumulation of Nrf2, but this was significantly reversed by the inhibition of p38 activation and ROS elimination.	ros	141-144	nuclear factor, erythroid derived 2, like 2	Mus musculus	59-63
30834779-11	2019	Collectively, our results suggest that ST-L and ST-B exerts potential anti-inflammatory activity by suppressing NF- kappa B and MAPK signaling activation, and activating HO-1 expression through the nuclear accumulation of Nrf2 via ROS-dependent p38 activation.	ros	231-234	nuclear factor, erythroid derived 2, like 2	Mus musculus	222-226
30723502-0	2019	Autophagy Regulated by Gain of Function Mutant p53 Enhances Proteasomal Inhibitor-Mediated Cell Death through Induction of ROS and ERK in Lung Cancer Cells.	ros	123-126	tumor protein p53	Homo sapiens	47-50
30460429-7	2019	Pretreatment of neurons with Cdh1 expressing lentivirus before OGD could reverse this metabolic shift and attenuated ROS-induced apoptosis.	ros	117-120	cadherin 1	Homo sapiens	29-33
30339829-7	2019	PM also caused ROS-dependent activation of MT-specific deacetylase, HDAC6.	ros	15-18	histone deacetylase 6	Homo sapiens	68-73
30421242-10	2019	Inhibition of VDAC1 oligomerization using 4,4"-Diisothiocyanatostilbene-2,2"-disulfonate (DIDS), significantly improved the cell survival, decreased the ROS levels, improved mitochondrial functions, and decreased the mitochondrial damage.	ros	153-156	voltage-dependent anion channel 1	Mus musculus	14-19
30240585-5	2019	IL-6 trans-signaling activation caused a significant increase in STAT3 phosphorylation, expression of adhesion molecules, ROS production and apoptosis in HRECs whereas a significant decrease in mitochondrial membrane potential and NO production was observed in IL-6 trans-signaling activated cells.	ros	122-125	interleukin 6	Homo sapiens	0-4
30400006-7	2019	We demonstrated that ATM deficiency shunted the glucose flux to aerobic glycolysis by upregulating LDHA expression, which generated more lactate and produced less mitochondrial ROS to promote CRPC cell growth.	ros	177-180	lactate dehydrogenase A	Homo sapiens	99-103
30400006-8	2019	Inhibition of LDHA by siRNA or inhibitor FX11 generated less lactate and accumulated more ROS in ATM-deficient CRPC cells and therefore potentiated the cell death of ATM-deficient CRPC cells.	ros	90-93	lactate dehydrogenase A	Homo sapiens	14-18
31162913-8	2019	TLR2/4 expression by H2O2 in presence of ROS-inhibitors or leptin/LPS/fatty acids was also assessed.	ros	41-44	toll like receptor 2	Homo sapiens	0-6
30439413-5	2019	We found that cyclo(His-Pro) inhibits NLRP3 inflammasome activation by reducing protein nitration via reduction in NO and ROS levels, indicative of lower peroxynitrite generation by LPS.	ros	122-125	NLR family pyrin domain containing 3	Homo sapiens	38-43
30467749-7	2019	Furthermore, PCB126 exposure altered the expression of some enzymes involved in ROS detoxification such as catalase and glutaredoxin 2.	ros	80-83	catalase	Rattus norvegicus	107-115
30467749-7	2019	Furthermore, PCB126 exposure altered the expression of some enzymes involved in ROS detoxification such as catalase and glutaredoxin 2.	ros	80-83	glutaredoxin	Rattus norvegicus	120-132
30662355-6	2019	Moreover, SFN reduced the Ang II-induced upregulation of HVSMC migration; this effect was inhibited by pretreatment with inhibitors of NADPH oxidase and ROS or transfection with siNOX4.	ros	153-156	angiotensinogen	Homo sapiens	26-32
30439413-7	2019	On the other hand, cyclo(His-Pro)-mediated ROS attenuation, not linked to Nrf2 activation in this cellular model, is ascribed to increased soluble SOD1 activity due to the up-regulation of Hsp70 and Hsp27 expression.	ros	43-46	superoxide dismutase 1	Homo sapiens	147-151
31401057-0	2019	ROS-mediated JNK pathway critically contributes to PFOS-triggered apoptosis in SH-SY5Y cells.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	13-16
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	55-58	mitogen-activated protein kinase 8	Homo sapiens	266-269
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	55-58	mitogen-activated protein kinase 8	Homo sapiens	266-269
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	55-58	mitogen-activated protein kinase 8	Homo sapiens	111-114
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	145-148	mitogen-activated protein kinase 8	Homo sapiens	111-114
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	145-148	mitogen-activated protein kinase 8	Homo sapiens	266-269
30744883-10	2019	It seems that stress induced reactive species (ROS, RNS) might be also responsible for the induced expression of NF-kappaB mRNA and Hsp70 protein which are considered as the reliable markers of certain types of stressors including PQ toxicity.	ros	47-50	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	113-122
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	145-148	mitogen-activated protein kinase 8	Homo sapiens	266-269
31401057-6	2019	In keeping with this notion, the expression of JNK downstream pro-apoptotic target Bim was increased following PFOS exposure in JNK- and ROS-dependent manners.	ros	137-140	mitogen-activated protein kinase 8	Homo sapiens	47-50
30744883-10	2019	It seems that stress induced reactive species (ROS, RNS) might be also responsible for the induced expression of NF-kappaB mRNA and Hsp70 protein which are considered as the reliable markers of certain types of stressors including PQ toxicity.	ros	47-50	heat shock protein 1B	Mus musculus	132-137
30599901-0	2019	Chronic infusion of berberine into the hypothalamic paraventricular nucleus attenuates hypertension and sympathoexcitation via the ROS/Erk1/2/iNOS pathway.	ros	131-134	nitric oxide synthase 2	Rattus norvegicus	142-146
30599901-8	2019	CONCLUSIONS: These results suggest that BBR attenuates hypertension and sympathoexcitation via the ROS/Erk1/2/iNOS pathway in 2K1C renovascular hypertensive rats.	ros	99-102	nitric oxide synthase 2	Rattus norvegicus	110-114
30368039-7	2019	SOD2 as a key enzyme can decrease mitochondrial ROS (mROS) level, Deacetylation of SOD2 by SIRT3 regulates SOD2 enzymatic activity has been identified.	ros	48-51	sirtuin 3	Homo sapiens	91-96
30391825-5	2019	Over-expression of a constitutively active PGC-1alpha-interactive domain (named as VBH135) of Bhlhe40 mimicked the effects of its knockdown on peroxisomes but simultaneously reduced ROS level.	ros	182-185	PPARG coactivator 1 alpha	Homo sapiens	43-53
30508483-0	2018	Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer.	ros	107-110	NAD(P)H quinone dehydrogenase 1	Homo sapiens	39-72
30394045-7	2018	In addition, inhibitors of the ROS scavenging enzyme induced expression of the ATG1 and ATG8 genes by increasing the levels of H2O2 and O2 -.	ros	31-34	ubiquitin-like protein ATG8	Saccharomyces cerevisiae S288C	88-92
30766661-6	2019	Moreover, TBBPA-induced activation of Akt/MAPK pathways and MMP-9 expression were attenuated by a specific NADPH oxidase inhibitor, and the ROS scavenger.	ros	140-143	AKT serine/threonine kinase 1	Homo sapiens	38-41
30508483-0	2018	Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer.	ros	107-110	NAD(P)H quinone dehydrogenase 1	Homo sapiens	74-78
30508483-1	2018	The elevation of oxidative stress preferentially in cancer cells by efficient NQO1 substrates, which promote ROS generation through redox cycling, has emerged as an effective strategy for cancer therapy, even for treating drug-resistant cancers.	ros	109-112	NAD(P)H quinone dehydrogenase 1	Homo sapiens	78-82
30508483-2	2018	Here, we described the identification and structural optimization studies of the hit compound 1, a new chemotype of nonquinone substrate for NQO1 as an efficient ROS generator.	ros	162-165	NAD(P)H quinone dehydrogenase 1	Homo sapiens	141-145
30508483-4	2018	Furthermore, 20k dramatically elevated the intracellular ROS levels through NQO1-catalyzed redox cycling and induced PARP-1-mediated cell apoptosis in A549/Taxol cells.	ros	57-60	NAD(P)H quinone dehydrogenase 1	Homo sapiens	76-80
30586869-7	2018	Interestingly, such combination treatments further increased intracellular ROS and cytotoxicity induced by the single TB or bortezomib treatment, suggesting that NRF2, HSF1 and p62/SQSTM1 keep the ROS level under control, allowing primary effusion lymphoma (PEL) cells to continue to survive and KSHV to replicate.	ros	75-78	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
30586869-7	2018	Interestingly, such combination treatments further increased intracellular ROS and cytotoxicity induced by the single TB or bortezomib treatment, suggesting that NRF2, HSF1 and p62/SQSTM1 keep the ROS level under control, allowing primary effusion lymphoma (PEL) cells to continue to survive and KSHV to replicate.	ros	197-200	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
30586869-0	2018	Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1.	ros	96-99	NFE2 like bZIP transcription factor 2	Homo sapiens	129-133
30572915-7	2018	Briefly, in MDR cells, the increase of ROS activated NF-kappaB signaling, which transcriptionally activated 14-3-3eta.	ros	39-42	nuclear factor kappa B subunit 1	Homo sapiens	53-62
30572915-7	2018	Briefly, in MDR cells, the increase of ROS activated NF-kappaB signaling, which transcriptionally activated 14-3-3eta.	ros	39-42	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta	Homo sapiens	108-117
30545412-0	2018	1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis.	ros	147-150	cytochrome c, somatic	Homo sapiens	119-131
30618739-0	2018	Bicyclol Attenuates Liver Inflammation Induced by Infection of Hepatitis C Virus via Repressing ROS-Mediated Activation of MAPK/NF-kappaB Signaling Pathway.	ros	96-99	nuclear factor kappa B subunit 1	Homo sapiens	128-137
30618739-5	2018	Bicyclol decreased the activation of NF-kappaB and the levels of inflammatory factors in HCV-infected hepatocytes by inhibiting the activation of the ROS-MAPK-NF-kappaB pathway, and the effect was synergistic with DAAs in HCV-infected hepatocytes.	ros	150-153	nuclear factor kappa B subunit 1	Homo sapiens	37-46
30029111-9	2018	This enhanced ROS inflicted severe inflammation and subsequent fibrosis, evident from increased pro-inflammatory-cum-fibrogenic cytokines generation (IL-1beta, IL-2, IL-6, TNF-alpha and TGF-beta).	ros	14-17	interleukin 1 beta	Homo sapiens	150-158
30029111-9	2018	This enhanced ROS inflicted severe inflammation and subsequent fibrosis, evident from increased pro-inflammatory-cum-fibrogenic cytokines generation (IL-1beta, IL-2, IL-6, TNF-alpha and TGF-beta).	ros	14-17	interleukin 2	Homo sapiens	160-164
30029111-9	2018	This enhanced ROS inflicted severe inflammation and subsequent fibrosis, evident from increased pro-inflammatory-cum-fibrogenic cytokines generation (IL-1beta, IL-2, IL-6, TNF-alpha and TGF-beta).	ros	14-17	interleukin 6	Homo sapiens	166-170
30029111-9	2018	This enhanced ROS inflicted severe inflammation and subsequent fibrosis, evident from increased pro-inflammatory-cum-fibrogenic cytokines generation (IL-1beta, IL-2, IL-6, TNF-alpha and TGF-beta).	ros	14-17	tumor necrosis factor	Homo sapiens	172-181
30029111-10	2018	Simultaneously, ROS induced persistent DNA-damage (Comet-assay) that stimulated G2/M arrest for p53-mediated damage-repair, aided by checkpoint-promoter (Chk1) activation and mitotic-inducers (i.e. Cdc-25, Cdk1, cyclinB1) inhibition.	ros	16-19	tumor protein p53	Homo sapiens	96-99
30618739-6	2018	Bicyclol attenuated the ROS-MAPK-NF-kappaB axis via recovering mitochondrial function without a dependence on dihydronicotinamide adenine dinucleotide phosphate oxidase and superoxide dismutases.	ros	24-27	nuclear factor kappa B subunit 1	Homo sapiens	33-42
30190370-9	2018	Further, we identified a distinct molecular mechanism by which AA-restriction reprograms macrophage function via a ROS/mTOR-centric cascade.	ros	115-118	mechanistic target of rapamycin kinase	Homo sapiens	119-123
30168649-5	2018	TXNIP-/- MEF cells showed greater induced glucose uptake and ROS levels than wild-type cells, and N-acetylcysteine (NAC) treatment rescued the cellular senescence of TXNIP-/- MEF cells.	ros	61-64	thioredoxin interacting protein	Mus musculus	0-5
30244523-3	2018	Here, we demonstrate that TGF-beta1, a component of the SASP, causes telomere dysfunction in normal somatic human fibroblasts in a Smad3/NOX4/ROS-dependent manner.	ros	142-145	transforming growth factor beta 1	Homo sapiens	26-35
30244512-1	2018	BACKGROUND: Ragweed pollen extract (RWPE) induces TLR4-NFkappaB-CXCL-dependent recruitment of ROS-generating neutrophils to the airway and OGG1 DNA glycosylase-dependent excision of oxidatively induced 8-OH-Gua DNA base lesions from the airway epithelial cell genome.	ros	94-97	toll-like receptor 4	Mus musculus	50-54
30261287-0	2018	Dysregulated Txnip-ROS-Wnt axis contributes to the impaired ischemic heart repair in diabetic mice.	ros	19-22	thioredoxin interacting protein	Mus musculus	13-18
30261287-13	2018	Diabetes-induced increase of TXNIP expression in the endothelium contributes to impaired angiogenesis after MI, especially via the elevation of ROS and the impaired Wnt/beta-catenin signaling.	ros	144-147	thioredoxin interacting protein	Mus musculus	29-34
30261287-14	2018	Targeting TXNIP-ROS-Wnt is a promising strategy in improving the prognosis.	ros	16-19	thioredoxin interacting protein	Mus musculus	10-15
30236770-9	2018	The inhibition of ROS production decreased NLRP3 inflammasome activation and IL-1beta production in CD4 T cells, leading to the suppression of Th17 differentiation.	ros	18-21	NLR family pyrin domain containing 3	Homo sapiens	43-48
30236770-9	2018	The inhibition of ROS production decreased NLRP3 inflammasome activation and IL-1beta production in CD4 T cells, leading to the suppression of Th17 differentiation.	ros	18-21	interleukin 1 beta	Homo sapiens	77-85
30278417-7	2018	Collectively, our results indicate a cytosolic ROS overproduction, inducing oxidative damage and activating oxygen sensitive NRF2 and NF-kB signaling pathways for all the cell models acutely or repeatedly exposed to PM2.5.	ros	47-50	NFE2 like bZIP transcription factor 2	Homo sapiens	125-129
30196390-8	2018	The ROS scavenger N-acetylcysteine (NAC) and the ROS formation inhibitor diphenyleneiodonium (DPI) also inhibited TNFalpha expression in stimulated macrophages, but unlike 3-AB, NAC and DPI were unable to abolish NFkappaB activity.	ros	4-7	tumor necrosis factor	Mus musculus	114-122
30196390-8	2018	The ROS scavenger N-acetylcysteine (NAC) and the ROS formation inhibitor diphenyleneiodonium (DPI) also inhibited TNFalpha expression in stimulated macrophages, but unlike 3-AB, NAC and DPI were unable to abolish NFkappaB activity.	ros	49-52	tumor necrosis factor	Mus musculus	114-122
30218773-8	2018	siRNA/shRNA-mediated knockdown of PDIA3 in HL7702 cells and rats played the same role as CA not only in inhibiting ROS production and NADPH oxidase activity, but also in alleviating hepatocytes injury.	ros	115-118	protein disulfide isomerase family A, member 3	Rattus norvegicus	34-39
30268890-10	2018	The transcription factor, NFkappaB, known to be activated by ROS, was shown to be involved in the increase in iNOS expression.	ros	61-64	nuclear factor kappa B subunit 1	Homo sapiens	26-34
30381241-10	2018	In conclusion: our data indicate that the increased vulnerability of the diabetic myocardium to I/R-induced apoptosis/dysfunction is attributable, in part, to decreased myocardial Sirt1 activity which leads to a decrease in Akt activation, an increase in Drp1 activity, culminating in excessive mitochondrial fission and ROS production.	ros	321-324	AKT serine/threonine kinase 1	Homo sapiens	224-227
30391882-0	2018	Vitamin E inhibits cyclosporin A-induced CTGF and TIMP-1 expression by repressing ROS-mediated activation of TGF-beta/Smad signaling pathway in rat liver.	ros	82-85	transforming growth factor, beta 1	Rattus norvegicus	109-117
29350342-9	2018	Interestingly, activated NK cells induced ROS generation within BM-MSCs that caused their decreased viability and reduced expression of serpin B9.	ros	42-45	serpin family B member 9	Homo sapiens	136-145
30365930-13	2018	treatment 10 min before reperfusion decreased the level of TNF-alpha following with a negatively regulating the RIP3 induced phosphor-MLKL/CaMKII signaling, thus significantly reduced ROS production and cardiomyocyte necroptosis and ameliorated cardiac function.	ros	184-187	tumor necrosis factor	Mus musculus	59-68
30190422-4	2018	PIM1 kinase functions to decrease cellular ROS levels by enhancing nuclear factor erythroid 2-related factor 2 (NRF2)/antioxidant response element activity.	ros	43-46	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
30190422-4	2018	PIM1 kinase functions to decrease cellular ROS levels by enhancing nuclear factor erythroid 2-related factor 2 (NRF2)/antioxidant response element activity.	ros	43-46	NFE2 like bZIP transcription factor 2	Homo sapiens	67-110
30190422-4	2018	PIM1 kinase functions to decrease cellular ROS levels by enhancing nuclear factor erythroid 2-related factor 2 (NRF2)/antioxidant response element activity.	ros	43-46	NFE2 like bZIP transcription factor 2	Homo sapiens	112-116
30190422-6	2018	Importantly, PIM also controls NAD(P)H production by increasing glucose flux through the pentose phosphate shunt decreasing ROS production, and thereby diminishing the cytotoxicity of PI3K-AKT inhibitors.	ros	124-127	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-16
30382449-5	2018	We further found that pre-treatment with ROS scavenger N-acetyl-L-cysteine (NAC) dramatically ameliorated PFOS-induced ROS production and Nrf2 signaling.	ros	41-44	NFE2 like bZIP transcription factor 2	Homo sapiens	138-142
30382449-7	2018	Moreover, antagonizing Nrf2 pathway with Nrf2 inhibitor brusatol resulted in increased ROS production and enhanced PFOS-induced expression of apoptosis related proteins.	ros	87-90	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
30382449-7	2018	Moreover, antagonizing Nrf2 pathway with Nrf2 inhibitor brusatol resulted in increased ROS production and enhanced PFOS-induced expression of apoptosis related proteins.	ros	87-90	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
29961397-6	2018	RESULTS: When challenged with hydrogen peroxide (H2O2), a ROS donor, both cell lines display fragmentation of the mitochondrial network and loss of fusion-active OPA1 isoforms, indicating that OPA1-mediated mitochondrial fusion is disrupted by oxidative damage in mammalian cells.	ros	58-61	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	193-197
30596104-0	2018	EGFR-Targeted Immunotoxin Exerts Antitumor Effects on Esophageal Cancers by Increasing ROS Accumulation and Inducing Apoptosis via Inhibition of the Nrf2-Keap1 Pathway.	ros	87-90	epidermal growth factor receptor	Homo sapiens	0-4
30196236-0	2018	The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells.	ros	50-53	tumor protein p53	Homo sapiens	11-14
30196236-0	2018	The Mutant p53-Targeting Compound APR-246 Induces ROS-Modulating Genes in Breast Cancer Cells.	ros	50-53	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	34-37
30564384-6	2018	Furthermore, Se@Ga enhanced the anti-cancer activity of HepG2 cells through ROS-mediated AKT and p38 signalling pathways.	ros	76-79	AKT serine/threonine kinase 1	Homo sapiens	89-92
30564384-6	2018	Furthermore, Se@Ga enhanced the anti-cancer activity of HepG2 cells through ROS-mediated AKT and p38 signalling pathways.	ros	76-79	mitogen-activated protein kinase 14	Homo sapiens	97-100
30534079-10	2018	In the heart and skeletal muscle, mitochondria, nicotinamide adenine dinucleotide phosphate (NADPH) oxidases, uncoupled nitric oxide synthase (NOS) and xanthine oxidase are major ROS sources producing superoxide anion (O2 -) and/or hydrogen peroxide (H2O2).	ros	179-182	nitric oxide synthase 2	Homo sapiens	120-141
30169763-7	2018	Simultaneously, the signaling pathway of ROS/JNK/FOXO3a of DON-induced cytotoxicity was newly proposed.	ros	41-44	mitogen-activated protein kinase 8	Homo sapiens	45-48
30169763-7	2018	Simultaneously, the signaling pathway of ROS/JNK/FOXO3a of DON-induced cytotoxicity was newly proposed.	ros	41-44	forkhead box O3	Homo sapiens	49-55
30169763-8	2018	In total, FOXO3a via ROS/JNK/FOXO3a plays a critical role to function as negative regulator associating with DON-induced cytotoxicity, with the potential extending to other substances.	ros	21-24	forkhead box O3	Homo sapiens	10-16
30169763-8	2018	In total, FOXO3a via ROS/JNK/FOXO3a plays a critical role to function as negative regulator associating with DON-induced cytotoxicity, with the potential extending to other substances.	ros	21-24	mitogen-activated protein kinase 8	Homo sapiens	25-28
30169763-8	2018	In total, FOXO3a via ROS/JNK/FOXO3a plays a critical role to function as negative regulator associating with DON-induced cytotoxicity, with the potential extending to other substances.	ros	21-24	forkhead box O3	Homo sapiens	29-35
30595666-4	2018	Importantly, anti-TNF-alpha mAb could inhibit neutrophils to produce proinflammatory mediators, such as ROS, calprotectin, IL-8, IL-6, and TNF-alpha.	ros	104-107	tumor necrosis factor	Homo sapiens	18-27
30265530-10	2018	Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox.	ros	66-69	AKT serine/threonine kinase 1	Homo sapiens	79-82
30584464-0	2018	High Glucose-Induced ROS Production Stimulates Proliferation of Pancreatic Cancer via Inactivating the JNK Pathway.	ros	21-24	mitogen-activated protein kinase 8	Homo sapiens	103-106
30584464-7	2018	Collectively, high levels of ROS induced by high glucose conditions stimulated the proliferation of pancreatic cancer cells, and it may be achieved by inactivating the JNK pathway.	ros	29-32	mitogen-activated protein kinase 8	Homo sapiens	168-171
30265530-0	2018	N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox.	ros	18-21	AKT serine/threonine kinase 1	Homo sapiens	31-34
30265530-10	2018	Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox.	ros	66-69	forkhead box O1	Homo sapiens	83-88
30265530-0	2018	N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox.	ros	18-21	forkhead box O1	Homo sapiens	35-40
30265530-10	2018	Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox.	ros	66-69	AKT serine/threonine kinase 1	Homo sapiens	93-96
30265530-0	2018	N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox.	ros	18-21	AKT serine/threonine kinase 1	Homo sapiens	45-48
30265530-0	2018	N-O Reduction and ROS-Mediated AKT/FOXO1 and AKT/P53 Pathways Are Involved in Growth Promotion and Cytotoxicity of Cyadox.	ros	18-21	tumor protein p53	Homo sapiens	49-52
30265530-10	2018	Thus, the present study revealed that N-O reduction of cyadox and ROS-mediated AKT/FOXO1 and AKT/P53 pathways were involved in growth promotion and cytotoxicity of cyadox.	ros	66-69	tumor protein p53	Homo sapiens	97-100
30662617-3	2018	A potent and selective irreversible CDK7 inhibitor THZ2 was able to induce cell growth inhibition, cell cycle arrest at G2/M phase and apoptosis with the increasing intracellular reactive oxidative species (ROS) levels in gastric cancer cells.	ros	207-210	cyclin dependent kinase 7	Homo sapiens	36-40
30446635-5	2018	We identified ROS could negatively regulate NMT1 expression and NMT1 knockdown conversely promoted oxidative stress, which formed a feedback loop.	ros	14-17	N-myristoyltransferase 1	Homo sapiens	44-48
30446635-6	2018	Furthermore, inhibition of NMT1 caused degraded proteins increase and ER stress, which cross-talked with mitochondria to produce more ROS.	ros	134-137	N-myristoyltransferase 1	Homo sapiens	27-31
30343565-9	2018	These results indicate that Gln deficiency activates autophagy by upregulating ROS-medicated JAK2/STAT3 signaling and thereby promoting PCV2 infection.	ros	79-82	signal transducer and activator of transcription 3	Homo sapiens	98-103
30428894-10	2018	Induction of apoptosis and p75 ICD internalization by AD patients-derived proBDNF is further enhanced in neuron cultures from the AD model expressing the APP/PS1 E9 transgene.Our results indicate the importance of proBDNF neurotoxic signaling in AD pathology essentially by three mechanisms: i) by an increase of proBDNF stability due to ROS-induced post-traductional modifications; ii) by the increase of expression of the p75 co-receptor, Sortilin and iii) by the increase of the basal levels of p75 processing found in AD.	ros	338-341	amyloid beta precursor protein	Homo sapiens	154-164
30459526-9	2018	In addition, IL-2 and sorafenib co-treatment promoted mitochondrial dysfunction, as evidenced by the decreased mitochondrial potential, elevated mitochondrial ROS production, increased leakage of mitochondrial pro-apoptotic factors, and activation of the mitochondrial death pathway.	ros	159-162	interleukin 2	Homo sapiens	13-17
30343565-0	2018	Glutamine Deficiency Promotes PCV2 Infection through Induction of Autophagy via Activation of ROS-Mediated JAK2/STAT3 Signaling Pathway.	ros	94-97	signal transducer and activator of transcription 3	Homo sapiens	112-117
30450046-5	2018	In vitro experiments revealed that pretreatment with NGR1 significantly decreased AGEs-induced mitochondria injury, limited an increase in ROS, and reduced apoptosis in H9c2 cells.	ros	139-142	reticulon 4 receptor	Rattus norvegicus	53-57
30343565-7	2018	Inhibition of ROS generation alleviated the Gln deficiency-activated JAK2/STAT3 signaling pathway, thereby inhibiting autophagy induction.	ros	14-17	signal transducer and activator of transcription 3	Homo sapiens	74-79
30403199-8	2018	Moreover, An reduced the ratio of Bax/Bcl-2 to ROS level.	ros	47-50	DDB1 and CUL4 associated factor 7	Homo sapiens	10-12
30237309-5	2018	TSC1 knockdown results in elevated mTORC1-dependent mitochondrial respiration enhanced ROS production and apoptosis.	ros	87-90	TSC complex subunit 1	Homo sapiens	0-4
30450046-6	2018	NGR1 eliminated ROS by promoting estrogen receptor alpha expression, which subsequently activated Akt and Nrf2-mediated anti-oxidant enzymes.	ros	16-19	reticulon 4 receptor	Rattus norvegicus	0-4
30450046-6	2018	NGR1 eliminated ROS by promoting estrogen receptor alpha expression, which subsequently activated Akt and Nrf2-mediated anti-oxidant enzymes.	ros	16-19	estrogen receptor 1	Homo sapiens	33-56
29286212-10	2018	We also indicated that CPEB4 knockdown increased the ROS expression.	ros	53-56	cytoplasmic polyadenylation element binding protein 4	Homo sapiens	23-28
30257355-11	2018	TLR4 knockdown reduced the intracellular level of ROS in conjunction with reduced IL-1beta, IL-18, TNF-alpha and TGF-beta1 levels in podocytes in the presence of HG.	ros	50-53	toll-like receptor 4	Mus musculus	0-4
29286212-12	2018	Taken all together, our data demonstrated that silencing of CPEB4 induces ROS generation, thus suppressing the Akt expression, which finally prevents NSCLC cells invasion and migration.	ros	74-77	cytoplasmic polyadenylation element binding protein 4	Homo sapiens	60-65
29800228-12	2018	Other studies revealed activation of ROS-ATM-LKB1-AMPK axis as a possible mechanism of PCSK-induced autophagy.	ros	37-40	serine/threonine kinase 11	Mus musculus	45-49
30236513-10	2018	To decipher the relationship between ROS generation, mitochondrial respiration flux, and AMPK signaling, mitochondrial metabolism and ROS was specifically inhibited, and the results show that AMPK inactivation and hypertrophic response in Trx2-silenced cells is reversed by respiration blockers but not ROS scavenger.	ros	134-137	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	89-93
30236513-10	2018	To decipher the relationship between ROS generation, mitochondrial respiration flux, and AMPK signaling, mitochondrial metabolism and ROS was specifically inhibited, and the results show that AMPK inactivation and hypertrophic response in Trx2-silenced cells is reversed by respiration blockers but not ROS scavenger.	ros	37-40	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	192-196
30236513-10	2018	To decipher the relationship between ROS generation, mitochondrial respiration flux, and AMPK signaling, mitochondrial metabolism and ROS was specifically inhibited, and the results show that AMPK inactivation and hypertrophic response in Trx2-silenced cells is reversed by respiration blockers but not ROS scavenger.	ros	134-137	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	89-93
29334793-6	2018	Moreover, Ru@MSNs induced ROS overproduction in cancer cells, leading to DNA damage and p53 phosphorylation, consequently promoting cancer cells apoptosis.	ros	26-29	tumor protein p53	Homo sapiens	88-91
29978911-7	2018	Protopheophorbide A inhibited HGF-induced downstream c-Met-dependent cell proliferation, survival, adhesion and migration through RAF/MEK/ERK and PI3K/PTEN/AKT signaling pathways modulation, ROS generation and activation of JNK and p38 pathways.	ros	191-194	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	53-58
30145470-0	2018	4-Methylcatechol prevents streptozotocin-induced acute kidney injury through modulating NGF/TrkA and ROS-related Akt/GSK3beta/beta-catenin pathways.	ros	101-104	AKT serine/threonine kinase 1	Homo sapiens	113-116
30259128-9	2018	The oncogenic mechanism involves a ROS-activated AKT/FOXO1/TWIST1 signaling pathway.	ros	35-38	thymoma viral proto-oncogene 1	Mus musculus	49-52
29427171-6	2018	CORD6 is caused firstly by lowered basal and GCAP1-dependent ROS-GC1 activity and secondly, by a shift in Ca2+ sensitivity of the ROS-GC1/GCAP1 complex that remains active in darkness.	ros	61-64	guanylate cyclase activator 1A	Homo sapiens	45-50
29427171-6	2018	CORD6 is caused firstly by lowered basal and GCAP1-dependent ROS-GC1 activity and secondly, by a shift in Ca2+ sensitivity of the ROS-GC1/GCAP1 complex that remains active in darkness.	ros	61-64	olfactomedin 4	Homo sapiens	65-68
29427171-6	2018	CORD6 is caused firstly by lowered basal and GCAP1-dependent ROS-GC1 activity and secondly, by a shift in Ca2+ sensitivity of the ROS-GC1/GCAP1 complex that remains active in darkness.	ros	61-64	guanylate cyclase activator 1A	Homo sapiens	138-143
30106126-0	2018	miR-291b-3p mediated ROS-induced endothelial cell dysfunction by targeting HUR.	ros	21-24	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	Mus musculus	75-78
30292830-9	2018	At the molecular level, Sirt1 overexpression attenuated TNFalpha-mediated mitochondrial damage, as evidenced by increased mitochondrial energy metabolism, decreased mitochondrial ROS generation, stabilized mitochondrial potential and blockage of the mitochondrial apoptotic pathway.	ros	179-182	tumor necrosis factor	Homo sapiens	56-64
29446046-9	2018	Furthermore, DMBT restrained ROS level under hypoxia via suppressing Nrf2/HO-1 pathway.	ros	29-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	69-73
29446046-9	2018	Furthermore, DMBT restrained ROS level under hypoxia via suppressing Nrf2/HO-1 pathway.	ros	29-32	heme oxygenase 1	Mus musculus	74-78
30385779-8	2018	Mitochondrial Ca2+ uptake and energetics were restored in TSPO KO mice, associated with decreased ROS, improved complex I activity and preserved mitophagy.	ros	98-101	translocator protein	Mus musculus	58-62
30346453-7	2018	HIF 1alpha siRNA down-regulated the HIF 1alpha level, which was induced by the common hypoxic tumor environment or the ROS (generated by PDT), enhanced the PDT efficacy and partly inhibited the tumor progression.	ros	119-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
30346453-7	2018	HIF 1alpha siRNA down-regulated the HIF 1alpha level, which was induced by the common hypoxic tumor environment or the ROS (generated by PDT), enhanced the PDT efficacy and partly inhibited the tumor progression.	ros	119-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	36-46
30277762-4	2018	The 3-HF-OMe probe was found to produce a ratiometric response toward ONOO- when bound to Abeta aggregates, resulting in a novel host-guest ensemble, which adds insight into the development of other ESIPT-based probes for the simultaneous sensing of fibrous proteins/peptides and environmental ROS/RNS.	ros	294-297	amyloid beta precursor protein	Homo sapiens	90-95
30213730-5	2018	In addition, ATO-treated U937 cells showed ROS-mediated inhibition of TET2 transcription, leading to downregulation of FOXP3 expression and in turn, suppression of FOXP3-mediated activation of Lyn and Akt.	ros	43-46	AKT serine/threonine kinase 1	Homo sapiens	201-204
30352992-8	2018	In contrast, the simultaneous stimulation of TLR2, TLR4 and TLR7/8 drives high levels of ROS, GSDMD cleavage and faster IL-1beta secretion.	ros	89-92	toll like receptor 2	Homo sapiens	45-49
30498348-9	2018	Cellular and molecular assays revealed that NGOs lead to ROS formation, cell cycle arrest, and apoptosis through the BAX and BCL2 pathway.	ros	57-60	BCL2 associated X, apoptosis regulator	Homo sapiens	117-120
30498348-9	2018	Cellular and molecular assays revealed that NGOs lead to ROS formation, cell cycle arrest, and apoptosis through the BAX and BCL2 pathway.	ros	57-60	BCL2 apoptosis regulator	Homo sapiens	125-129
30352992-8	2018	In contrast, the simultaneous stimulation of TLR2, TLR4 and TLR7/8 drives high levels of ROS, GSDMD cleavage and faster IL-1beta secretion.	ros	89-92	toll like receptor 7	Homo sapiens	60-66
30425781-11	2018	Taken together, these results demonstrate that 4-PG can increase HO-1 expression, which plays a critical role in ameliorating intracellular and mitochondrial ROS production, as well as in downregulating inflammatory responses induced by LPS.	ros	158-161	heme oxygenase 1	Mus musculus	65-69
30459934-10	2018	siRNA-mediated knockdown of TPK1 directly enhanced basal ROS levels and reduced tumor cell proliferation.	ros	57-60	thiamin pyrophosphokinase 1	Homo sapiens	28-32
30255893-5	2018	beta-conglutin proteins were able to suppress the oxidative stress produced by insulin-induced resistance on PANC-1 control (C) cells by strongly reducing the protein oxidative carbonylation induced by ROS and balancing the metabolic homeostasis in IR-C cells through regulation of mRNA expression.	ros	202-205	insulin	Homo sapiens	79-86
30333316-5	2018	Exploring the functional consequence of increased GJA1-20k, we found that AAV9-mediated gene transfer of GJA1-20k in mouse hearts increases mitochondrial biogenesis while reducing mitochondrial membrane potential, respiration, and ROS production.	ros	231-234	gap junction protein, alpha 1	Mus musculus	105-109
29990859-5	2018	Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPARgamma antagonist.	ros	169-172	peroxisome proliferator activated receptor gamma	Homo sapiens	225-234
30323337-5	2018	Mechanistically, TA depletion combined with HER2 inhibition significantly reduces cellular NADPH levels, resulting in excessive ROS production and deficient lipid and nucleotide synthesis.	ros	128-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	44-48
30410328-8	2018	Moreover, Au-Ag@PDA NPs decreased the expression of phosphorylated AKT and ERK and promoted the production of ROS that function upstream of apoptosis and autophagy.	ros	110-113	AKT serine/threonine kinase 1	Homo sapiens	67-70
30410328-8	2018	Moreover, Au-Ag@PDA NPs decreased the expression of phosphorylated AKT and ERK and promoted the production of ROS that function upstream of apoptosis and autophagy.	ros	110-113	mitogen-activated protein kinase 1	Homo sapiens	75-78
29990859-5	2018	Furthermore, oxidative stress plays a major role in the pathology of cardiovascular diseases; we showed that AGP triggers ROS generation and lipid peroxidation and that ROS and 8-isoprostane generation can be suppressed by a PPARgamma antagonist.	ros	122-125	peroxisome proliferator activated receptor gamma	Homo sapiens	225-234
30336641-6	2018	ROS scavenging activity was assessed using electron paramagnetic spin resonance and quantification of ARE/Nrf2 mediated gene expression.	ros	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
30096402-4	2018	It was shown that the lactoferrin nanoparticle repolarized the tumor-associated macrophages from the M2 phenotype to M1 via regulating the STAT6 pathway, as well as induced the ROS-mediated mitochondrial apoptosis by inhibiting the Ras/Raf/p-Erk pathway in the glioma cells.	ros	177-180	mitogen-activated protein kinase 1	Homo sapiens	242-245
29960166-0	2018	ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine.	ros	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	31-34
29960166-10	2018	Studies in Bax-Bak knock-out cell model indicated that TDZ trigger both the Bax-Bak dependent and independent apoptosis through ROS.	ros	128-131	BCL2 associated X, apoptosis regulator	Homo sapiens	11-14
29960166-10	2018	Studies in Bax-Bak knock-out cell model indicated that TDZ trigger both the Bax-Bak dependent and independent apoptosis through ROS.	ros	128-131	BCL2 associated X, apoptosis regulator	Homo sapiens	76-79
29960166-12	2018	Both Bax-Bak dependent and independent apoptosis were significantly inhibited by ROS inhibitor NAC.	ros	81-84	BCL2 associated X, apoptosis regulator	Homo sapiens	5-8
29960166-13	2018	Conclusively, TDZ induced Bax-Bak dependent and independent apoptosis by enhancing ROS production followed by ER stress.	ros	83-86	BCL2 associated X, apoptosis regulator	Homo sapiens	26-29
29990859-6	2018	These results suggest that an imbalance of the PPARgamma agonist-antagonist equilibrium is involved in changes in cellular functions, including ROS generation and lipid peroxidation.	ros	144-147	peroxisome proliferator activated receptor gamma	Homo sapiens	47-56
29857117-4	2018	The results showed that inhibition of PDGFRbeta by CP-673451 induced a significant increase in cell apoptosis, accompanied by ROS accumulation.	ros	126-129	platelet derived growth factor receptor beta	Homo sapiens	38-47
29744878-0	2018	Photochemical tissue bonding promotes the proliferation and migration of injured tenocytes through ROS/RhoA/NF-kappaB/Dynamin 2 signaling pathway.	ros	99-102	nuclear factor kappa B subunit 1	Homo sapiens	108-117
29744878-8	2018	Individual treatment with inhibitor of NF-kappaB, ROS, and RhoA in tenocytes showed decreased protein expression of DNM2, TGF-beta1, and VEGF.	ros	50-53	transforming growth factor beta 1	Homo sapiens	122-131
29744878-8	2018	Individual treatment with inhibitor of NF-kappaB, ROS, and RhoA in tenocytes showed decreased protein expression of DNM2, TGF-beta1, and VEGF.	ros	50-53	vascular endothelial growth factor A	Homo sapiens	137-141
29857117-10	2018	Specifically, Nrf2 plays an indispensable role in NSCLC cell sensitivity to platinum-based treatments and we found that combination of CP-673451 and cisplatin produced a synergistic anticancer effect and substantial ROS production in vitro.	ros	216-219	NFE2 like bZIP transcription factor 2	Homo sapiens	14-18
29857117-8	2018	Rescue of Nrf2 activity counteracted the effects of CP-673451 on cell apoptosis and ROS accumulation.	ros	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	10-14
29857117-9	2018	Silencing PDGFRbeta expression by PDGFRbeta siRNA exerted similar effects with CP-673451 in A549 cells, and when PDGFRbeta was knockdowned by PDGFRbeta siRNA, CP-673451 produced no additional effects on cell viability, ROS and GSH production, Nrf2 expression as well as PI3K/Akt pathway activity.	ros	219-222	platelet derived growth factor receptor beta	Homo sapiens	10-19
29964052-9	2018	However, after ROS scavenger NAC was added to the cancer cells treated by resveratrol, DNMT1, DLC1 and senescence-associated molecular markers were reversed.	ros	15-18	DLC1 Rho GTPase activating protein	Homo sapiens	94-98
29990561-3	2018	All three compounds were found to enhance the intracellular ROS level in the dichlorofluorescein assay (&gt;= 1muM), even though substantial differences were observed in their cytotoxic potential.	ros	60-63	latexin	Homo sapiens	111-114
30250025-5	2018	At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway.	ros	81-84	mechanistic target of rapamycin kinase	Homo sapiens	153-157
29964052-10	2018	This reveals that resveratrol induced cancer cellular senescence through DLC1 in a ROS-dependent manner.	ros	83-86	DLC1 Rho GTPase activating protein	Homo sapiens	73-77
29964052-13	2018	Finally, resveratrol increased ROS production to induce DNA damage with p-CHK1 up-regulation and result in cancer cellular senescence.	ros	31-34	checkpoint kinase 1	Homo sapiens	74-78
30031131-7	2018	Here we showed that TNF-alpha-induced production of ROS and nSMase activation requires caveolin.	ros	52-55	tumor necrosis factor	Homo sapiens	20-29
30217146-8	2018	Moreover, the process of NLRP3 inflammasome activation and IL-1beta production in macrophages in response to T. pallidum infection involves K+ efflux, mitochondrial ROS production and cathepsin release.	ros	165-168	NLR family pyrin domain containing 3	Homo sapiens	25-30
30125721-6	2018	The mechanism studies indicated the mitochondrial localization of BODIPY3-PEG3 was able to generate ROS in mitochondria, which further result in mitochondrial dysfunction and photoinduced apoptosis via caspase-8 and caspase-3 pathway.	ros	100-103	caspase 3	Homo sapiens	216-225
30245856-0	2018	Autophagy regulates vinorelbine sensitivity due to continued Keap1-mediated ROS generation in lung adenocarcinoma cells.	ros	76-79	kelch like ECH associated protein 1	Homo sapiens	61-66
30245856-12	2018	According to these findings, autophagy regulates vinorelbine sensitivity by continuing Keap1-mediated ROS generation in lung adenocarcinoma cells.	ros	102-105	kelch like ECH associated protein 1	Homo sapiens	87-92
30095923-6	2018	Unexpectedly, SIRT3 overexpression increased ROS levels, and sensitized cells to oxidative stress.	ros	45-48	sirtuin 3	Homo sapiens	14-19
29947028-10	2018	Pep19-2.5 increased cytosolic calcium and mitochondrial ROS, which were involved in peptide-induced migration and ERK1/2 phosphorylation.	ros	56-59	mitogen-activated protein kinase 3	Homo sapiens	114-120
30196062-7	2018	Besides, 8 showed antiproliferative ability against NCI-H460 cells in a time- and concentration-dependent manner through modulating ROS to induce caspase-3-mediated pyroptosis, and displayed a better safety profile in vivo.	ros	132-135	caspase 3	Homo sapiens	146-155
29913410-8	2018	IA reduced Abeta-mediated ROS production (revealed by decreased intracellular ROS and MDA level, and increased SOD, CAT, and GPX contents), and inhibited Abeta-induced inflammation (marked by down-regulated expression of IL1b, TNFa, NfKb, and Cox2 genes).	ros	26-29	amyloid beta precursor protein	Homo sapiens	11-16
29913410-8	2018	IA reduced Abeta-mediated ROS production (revealed by decreased intracellular ROS and MDA level, and increased SOD, CAT, and GPX contents), and inhibited Abeta-induced inflammation (marked by down-regulated expression of IL1b, TNFa, NfKb, and Cox2 genes).	ros	78-81	amyloid beta precursor protein	Homo sapiens	11-16
30103900-5	2018	STAT3 translocation to the mitochondria and binding to a component of the respiratory chain complex I causes ROS accumulation.	ros	109-112	signal transducer and activator of transcription 3	Homo sapiens	0-5
30181309-0	2018	Retraction: ROS and CHOP Are Critical for Dibenzylideneacetone to Sensitize Tumor Cells to TRAIL through Induction of Death Receptors and Downregulation of Cell Survival Proteins.	ros	12-15	TNF superfamily member 10	Homo sapiens	91-96
29782967-9	2018	Furthermore, this response upon PGC-1alpha expression after IL-2 stimulation promoted an increase in ROS production in NK cells from elderly humans, while no increase in ROS production was observed in NK cells of young donors.	ros	101-104	PPARG coactivator 1 alpha	Homo sapiens	32-42
30021354-6	2018	Furthermore, Sirt3 deletion was also associated with mitochondrial membrane potential reduction, ROS overproduction, mPTP opening, mitochondrial pro-apoptotic upregulation, and caspase-9-related death programme activation.	ros	97-100	sirtuin 3	Homo sapiens	13-18
29782967-9	2018	Furthermore, this response upon PGC-1alpha expression after IL-2 stimulation promoted an increase in ROS production in NK cells from elderly humans, while no increase in ROS production was observed in NK cells of young donors.	ros	101-104	interleukin 2	Homo sapiens	60-64
29782967-9	2018	Furthermore, this response upon PGC-1alpha expression after IL-2 stimulation promoted an increase in ROS production in NK cells from elderly humans, while no increase in ROS production was observed in NK cells of young donors.	ros	170-173	PPARG coactivator 1 alpha	Homo sapiens	32-42
29782967-10	2018	Our data show that IL-2 stimulates NK cell effector function through a signaling pathway which involves a PGC-1alpha-dependent mitochondrial function in young NK cells, however it seems that NK cells from older donors exhibit an altered IL-2 signaling which affects mitochondrial function associated with an increased production of ROS which could represent a feature of NK cell senescence.	ros	332-335	interleukin 2	Homo sapiens	19-23
29782967-10	2018	Our data show that IL-2 stimulates NK cell effector function through a signaling pathway which involves a PGC-1alpha-dependent mitochondrial function in young NK cells, however it seems that NK cells from older donors exhibit an altered IL-2 signaling which affects mitochondrial function associated with an increased production of ROS which could represent a feature of NK cell senescence.	ros	332-335	PPARG coactivator 1 alpha	Homo sapiens	106-116
29782967-10	2018	Our data show that IL-2 stimulates NK cell effector function through a signaling pathway which involves a PGC-1alpha-dependent mitochondrial function in young NK cells, however it seems that NK cells from older donors exhibit an altered IL-2 signaling which affects mitochondrial function associated with an increased production of ROS which could represent a feature of NK cell senescence.	ros	332-335	interleukin 2	Homo sapiens	237-241
29806884-11	2018	Ligustrazine promoted oxidative stress response by increasing SOD level, decreasing MDA level, and inhibiting ROS production in IL-1beta-induced chondrocytes.	ros	110-113	interleukin 1 beta	Homo sapiens	128-136
29929000-0	2018	Telmisartan generates ROS-dependent upregulation of death receptor 5 to sensitize TRAIL in lung cancer via inhibition of autophagy flux.	ros	22-25	TNF superfamily member 10	Homo sapiens	82-87
29929000-6	2018	The molecular mechanism includes the blocking of AMPK phosphorylation causes inhibition of autophagy flux by telmisartan resulting in ROS generation leading to death receptor (DR5) upregulation and subsequent activation of the caspase cascade by TRAIL treatment.	ros	134-137	TNF superfamily member 10	Homo sapiens	246-251
29806884-13	2018	Furthermore, ligustrazine blocked NF-kappaB pathway in IL-1beta-induced chondrocytes, and PTDC (NF-kappaB inhibitor) enhanced the effect of ligustrazine on viability, apoptosis, SOX9 expression, and ROS production in IL-1beta-induced chondrocytes.	ros	199-202	nuclear factor kappa B subunit 1	Homo sapiens	96-105
29921037-5	2018	H2 remarkably decreased ROS accumulation and enhanced antioxidant enzymes activities by up-regulating expression of Nrf2 and its downstream components in wound tissue and/or H2 O2 -treated endothelia.	ros	24-27	nuclear factor, erythroid derived 2, like 2	Mus musculus	116-120
29487387-5	2018	NRF1 and NRF2 decrease upon MALAT1 targeting was due to transcriptional activation of their negative regulator KEAP1, and resulted in reduced expression of anti-oxidant genes and increased ROS levels.	ros	189-192	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
30059901-4	2018	Knockdown of NNT caused significantly NADPH reduction, induced high levels of ROS and significant cell apoptosis under oxidative stress conditions such as glucose deprival and anoikis.	ros	78-81	nicotinamide nucleotide transhydrogenase	Homo sapiens	13-16
30031063-12	2018	Furthermore, apoptosis was induced in TRAIL-resistant lung cancer cells with a co-treatment of resveratrol and TRAIL assessed by the loss of MMP, ROS generations which resulting the translocation of cytochrome c from the mitochondria into the cytosol due to mitochondrial dysfunction.	ros	146-149	TNF superfamily member 10	Homo sapiens	38-43
30031063-12	2018	Furthermore, apoptosis was induced in TRAIL-resistant lung cancer cells with a co-treatment of resveratrol and TRAIL assessed by the loss of MMP, ROS generations which resulting the translocation of cytochrome c from the mitochondria into the cytosol due to mitochondrial dysfunction.	ros	146-149	TNF superfamily member 10	Homo sapiens	111-116
30031063-12	2018	Furthermore, apoptosis was induced in TRAIL-resistant lung cancer cells with a co-treatment of resveratrol and TRAIL assessed by the loss of MMP, ROS generations which resulting the translocation of cytochrome c from the mitochondria into the cytosol due to mitochondrial dysfunction.	ros	146-149	cytochrome c, somatic	Homo sapiens	199-211
30014902-6	2018	Furthermore, the data from the treatment or transfection of miR-200a minic, Keap1 and TXNIP siRNA, Nrf2 activator and ROS inhibitor demonstrated that fructose-induced miR-200a low-expression increased Keap1 to block Nrf2 antioxidant pathway, and then enhanced ROS-driven TXNIP to activate NLRP3 inflammasome and disturb lipid metabolism-related proteins, causing inflammation and lipid deposition in BRL-3A cells.	ros	118-121	microRNA 200a	Rattus norvegicus	167-175
30014902-6	2018	Furthermore, the data from the treatment or transfection of miR-200a minic, Keap1 and TXNIP siRNA, Nrf2 activator and ROS inhibitor demonstrated that fructose-induced miR-200a low-expression increased Keap1 to block Nrf2 antioxidant pathway, and then enhanced ROS-driven TXNIP to activate NLRP3 inflammasome and disturb lipid metabolism-related proteins, causing inflammation and lipid deposition in BRL-3A cells.	ros	260-263	microRNA 200a	Rattus norvegicus	167-175
29940424-5	2018	Results showed that signaling levels of cellular ROS generated by TNFalpha, induced enrichment of OGG1 at specific sites of chromatinized DNA, primarily in the regulatory regions of genes.	ros	49-52	tumor necrosis factor	Mus musculus	66-74
29940424-8	2018	Taken together these data show TNFalpha-ROS-driven enrichment of OGG1 at gene regulatory regions in the chromatinized DNA, which is a prerequisite to modulation of gene expression for prompt cellular responses to oxidant stress.	ros	40-43	tumor necrosis factor	Mus musculus	31-39
30102256-6	2018	Mechanistically, ROS produced in diabetes induced c-Src-dependent but VEGF-C-independent VEGFR3 phosphorylation, and upregulated epsins through the activation of transcription factor AP-1.	ros	17-20	vascular endothelial growth factor C	Mus musculus	70-76
29940354-7	2018	A C60 fullerene photoactivation with violet light induced substantial ROS generation and apoptotic cell death, confirmed by caspase3/7 activation and plasma membrane phosphatidylserine externalization.	ros	70-73	caspase 3	Homo sapiens	124-132
30210529-5	2018	The mitochondrial ROS-mediated HIF-1alpha stabilization was identified as a key player at contributing to the MD, pointing it as a novel target for future therapeutical intervention.	ros	18-21	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
30214444-0	2018	ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1beta Activation During Streptococcus pneumoniae Infection.	ros	56-59	interleukin 1 beta	Mus musculus	70-78
30214444-7	2018	Moreover, mitochondrial IL-1beta production by bone marrow-derived macrophages was significantly reduced in ATF3 KO mice as a result of the disruption of cellular ROS and Ca2+ homeostasis.	ros	163-166	interleukin 1 beta	Mus musculus	24-32
30149527-8	2018	HO-1 inhibitors significantly increased intracellular ROS levels and suppressed cell migration and invasion.	ros	54-57	heme oxygenase 1	Mus musculus	0-4
30135544-7	2018	As shown by immunoblotting and flow cytometry, human PrP located in the cytoplasm displays considerably greater PK resistance and aggregation ability and is associated with considerably higher cellular ROS levels than PrP located on the plasma membrane.	ros	202-205	prion protein	Homo sapiens	53-56
30603372-6	2018	Notably, selenoprotein P impairs health-promoting effects of exercise by inhibiting ROS/AMPK/PGC-1alpha pathway in the skeletal muscle through its receptor LRP1.	ros	84-87	selenoprotein P	Homo sapiens	9-24
30603372-6	2018	Notably, selenoprotein P impairs health-promoting effects of exercise by inhibiting ROS/AMPK/PGC-1alpha pathway in the skeletal muscle through its receptor LRP1.	ros	84-87	PPARG coactivator 1 alpha	Homo sapiens	93-103
30603372-6	2018	Notably, selenoprotein P impairs health-promoting effects of exercise by inhibiting ROS/AMPK/PGC-1alpha pathway in the skeletal muscle through its receptor LRP1.	ros	84-87	LDL receptor related protein 1	Homo sapiens	156-160
30096926-4	2018	We then examine how alterations in the relative amounts of these states could alter signaling through the Src-EGFR-ROS pathway.	ros	115-118	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	106-109
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	ros	138-141	nuclear factor kappa B subunit 1	Homo sapiens	142-151
29993075-8	2018	The underlying mechanism of quercetin"s benefit on the liver may be explained by its anti-oxidant properties and inhibitory effect on the ROS/NF-kappaB/NLRP3 inflammasome/IL-1beta and IL-18 pathway by inducing HO-1.	ros	138-141	NLR family pyrin domain containing 3	Homo sapiens	152-157
30111296-15	2018	Moreover, drug-loaded nano-cubosomes produced a notable escalation in ROS levels, evident as an increase in NADPH oxidase, inhibition of LDH and a consequential upsurge in caspase-3.	ros	70-73	caspase 3	Homo sapiens	172-181
30096926-4	2018	We then examine how alterations in the relative amounts of these states could alter signaling through the Src-EGFR-ROS pathway.	ros	115-118	epidermal growth factor receptor	Homo sapiens	110-114
30086537-5	2018	Together, our findings indicate that the decline in GRSF1 levels during cellular senescence contributes to impairing mitochondrial function, elevating ROS and DNA damage, suppressing growth, and implementing a pro-inflammatory program.	ros	151-154	G-rich RNA sequence binding factor 1	Homo sapiens	52-57
30174713-5	2018	Objective: To study the effect of the p38 MAPK pathway activated by the generated ROS on apoptosis and the expression of the genes related to the balance of the extracellular matrix metabolism during treatment of sciatica with Mongolian medical warm acupuncture.	ros	82-85	mitogen-activated protein kinase 14	Homo sapiens	38-41
30135653-8	2018	Rapamycin also induced ROS generation and latent TGF-beta activation which contributed to TGF-beta-Smad signaling.	ros	23-26	transforming growth factor beta 1	Homo sapiens	90-98
29694924-4	2018	TAZ-KO cells exhibit mitochondrial deficits consistent with other models of BTHS, including accumulation of monolyso-CL (MLCL), decreased mitochondrial respiration, and increased mitochondrial ROS production.	ros	193-196	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	0-3
30048924-5	2018	The intracellular localization assay confirmed that the complex 1 was effectively distributed into mitochondria as well as endoplasmic reticulum (ER), and executed a ROS-mediated calcium and Bax/Bak dependent intrinsic apoptosis.	ros	166-169	BCL2 associated X, apoptosis regulator	Homo sapiens	191-194
30048924-6	2018	Interestingly, direct interaction between complex 1 and glucose regulated protein 78 (GRP78), a protein associated with drug resistance caused the ROS-mediated ubiquitination of GRP78.	ros	147-150	heat shock protein family A (Hsp70) member 5	Homo sapiens	56-84
30048924-6	2018	Interestingly, direct interaction between complex 1 and glucose regulated protein 78 (GRP78), a protein associated with drug resistance caused the ROS-mediated ubiquitination of GRP78.	ros	147-150	heat shock protein family A (Hsp70) member 5	Homo sapiens	86-91
30048924-6	2018	Interestingly, direct interaction between complex 1 and glucose regulated protein 78 (GRP78), a protein associated with drug resistance caused the ROS-mediated ubiquitination of GRP78.	ros	147-150	heat shock protein family A (Hsp70) member 5	Homo sapiens	178-183
29323338-7	2018	Furthermore, UTI pretreatment significantly suppressed LPS-induced ROS production by activating PI3K/Akt pathways and the nuclear translocation of Nrf2 via promotion of p62-associated Keap1 degradation.	ros	67-70	thymoma viral proto-oncogene 1	Mus musculus	101-104
29729479-0	2018	Palmitate lipotoxicity in enteric glial cells: Lipid remodeling and mitochondrial ROS are responsible for cyt c release outside mitochondria.	ros	82-85	cytochrome c, somatic	Homo sapiens	106-111
29729479-9	2018	Mitochondrial ROS permeation into the cytosol and palmitate-induced ER stress activated JNK and p38, culminating in Bim and Bax overexpression, factors known to increase the outer mitochondrial membrane permeability.	ros	14-17	mitogen-activated protein kinase 14	Homo sapiens	96-99
29753142-8	2018	Thereby, the antiviral activity of ROS/Nrf2/HO-1 axis was confirmed in EPC cells.	ros	35-38	NFE2 like bZIP transcription factor 2	Homo sapiens	39-43
29729479-9	2018	Mitochondrial ROS permeation into the cytosol and palmitate-induced ER stress activated JNK and p38, culminating in Bim and Bax overexpression, factors known to increase the outer mitochondrial membrane permeability.	ros	14-17	BCL2 associated X, apoptosis regulator	Homo sapiens	124-127
29852354-11	2018	We also found that suppression of EZH2 induced ROS generation and MMP loss in both EJ and T24 cells.	ros	47-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-38
29852354-12	2018	Conversely, up-regulation of EZH2 suppressed ROS generation and MMP loss.	ros	45-48	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	29-33
29482400-8	2018	ROS production was only inhibited with R-PNPs at concentrations of 2.5 and 5 muM.	ros	0-3	latexin	Homo sapiens	77-80
29922854-0	2018	fMLP-dependent activation of Akt and ERK1/2 through ROS/Rho A pathways is mediated through restricted activation of the FPRL1 (FPR2) receptor.	ros	52-55	formyl peptide receptor 1	Homo sapiens	0-4
29922854-0	2018	fMLP-dependent activation of Akt and ERK1/2 through ROS/Rho A pathways is mediated through restricted activation of the FPRL1 (FPR2) receptor.	ros	52-55	AKT serine/threonine kinase 1	Homo sapiens	29-32
29922854-0	2018	fMLP-dependent activation of Akt and ERK1/2 through ROS/Rho A pathways is mediated through restricted activation of the FPRL1 (FPR2) receptor.	ros	52-55	mitogen-activated protein kinase 3	Homo sapiens	37-43
29922854-0	2018	fMLP-dependent activation of Akt and ERK1/2 through ROS/Rho A pathways is mediated through restricted activation of the FPRL1 (FPR2) receptor.	ros	52-55	ras homolog family member A	Homo sapiens	56-61
29922854-10	2018	CONCLUSION: Collectively, these data suggested that fMLP-activated ERK1/2 and Akt pathways through specific activation of the FPRL1/ROS/RoA-GTPase pathway.	ros	132-135	formyl peptide receptor 1	Homo sapiens	52-56
29922854-10	2018	CONCLUSION: Collectively, these data suggested that fMLP-activated ERK1/2 and Akt pathways through specific activation of the FPRL1/ROS/RoA-GTPase pathway.	ros	132-135	mitogen-activated protein kinase 3	Homo sapiens	67-73
29922854-10	2018	CONCLUSION: Collectively, these data suggested that fMLP-activated ERK1/2 and Akt pathways through specific activation of the FPRL1/ROS/RoA-GTPase pathway.	ros	132-135	AKT serine/threonine kinase 1	Homo sapiens	78-81
29323702-1	2018	Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by targeting several key proteins, such as those involved in mitochondrial function and antioxidant defenses.	ros	70-73	sirtuin 3	Homo sapiens	0-9
29323702-1	2018	Sirtuin 3 (SIRT3) is the major mitochondria deacetylase and regulates ROS levels by targeting several key proteins, such as those involved in mitochondrial function and antioxidant defenses.	ros	70-73	sirtuin 3	Homo sapiens	11-16
29323702-2	2018	This way, SIRT3 balances ROS production and scavenging and promotes cell survival.	ros	25-28	sirtuin 3	Homo sapiens	10-15
29323702-5	2018	Results showed that after SIRT3 silencing, both ROS levels and production were increased, and antioxidant enzymes gene expression was significantly reduced.	ros	48-51	sirtuin 3	Homo sapiens	26-31
29323702-7	2018	Combination of SIRT3 knockdown with oxaliplatin treatment further increased ROS production and apoptosis, reducing cell viability.	ros	76-79	sirtuin 3	Homo sapiens	15-20
29675777-8	2018	The knockdown of p16INK4A also induced antioxidant properties as indicated by a 50% decrease in ROS generation at basal cell metabolism, and a 25% decrease in ROS generation after exposure to oxidative stress.	ros	96-99	cyclin dependent kinase inhibitor 2A	Homo sapiens	17-25
29863983-10	2018	Both H1299 rho0 and rho+ cells had higher ROS levels after irradiation, however, the radiation-induced ROS production in rho0 cells was significantly lower than in rho+ cells.	ros	42-45	rhodopsin	Homo sapiens	5-23
29863983-10	2018	Both H1299 rho0 and rho+ cells had higher ROS levels after irradiation, however, the radiation-induced ROS production in rho0 cells was significantly lower than in rho+ cells.	ros	103-106	rhodopsin	Homo sapiens	5-23
29675777-8	2018	The knockdown of p16INK4A also induced antioxidant properties as indicated by a 50% decrease in ROS generation at basal cell metabolism, and a 25% decrease in ROS generation after exposure to oxidative stress.	ros	159-162	cyclin dependent kinase inhibitor 2A	Homo sapiens	17-25
29794378-8	2018	Based on these findings, we propose that the alteration of GGPPS expression changed the Rac1 activity and ROS production, and finally led to the different severity of HR-induced injury in H9c2 cells.	ros	106-109	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	59-64
30029680-0	2018	Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.	ros	42-45	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	14-18
29794378-7	2018	Furthermore, overexpression of GGPPS increased Rac1 activity and ROS generation, while GGPPS silencing decreased Rac1 activity and ROS generation.	ros	65-68	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	31-36
29794378-7	2018	Furthermore, overexpression of GGPPS increased Rac1 activity and ROS generation, while GGPPS silencing decreased Rac1 activity and ROS generation.	ros	131-134	geranylgeranyl diphosphate synthase 1	Rattus norvegicus	87-92
30029680-13	2018	CONCLUSION: Our results show that oxaliplatin mediates differential cellular responses in colon cancer cells depending on their p53 status, and demonstrate that the ROS-p53 axis is important for regulating POU3F2 and its downstream target, tNOX.	ros	165-168	tumor protein p53	Homo sapiens	169-172
30029680-0	2018	Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.	ros	42-45	tumor protein p53	Homo sapiens	46-49
30029680-13	2018	CONCLUSION: Our results show that oxaliplatin mediates differential cellular responses in colon cancer cells depending on their p53 status, and demonstrate that the ROS-p53 axis is important for regulating POU3F2 and its downstream target, tNOX.	ros	165-168	POU class 3 homeobox 2	Homo sapiens	206-212
30029680-0	2018	Regulation of tNOX expression through the ROS-p53-POU3F2 axis contributes to cellular responses against oxaliplatin in human colon cancer cells.	ros	42-45	POU class 3 homeobox 2	Homo sapiens	50-56
30029680-13	2018	CONCLUSION: Our results show that oxaliplatin mediates differential cellular responses in colon cancer cells depending on their p53 status, and demonstrate that the ROS-p53 axis is important for regulating POU3F2 and its downstream target, tNOX.	ros	165-168	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	240-244
30029680-10	2018	Further experiments revealed that in p53-wild-type cells, oxaliplatin enhanced ROS generation and p53 transcriptional activation, leading to down-regulation of the transcriptional factor, POU3F2, which enhances the expression of tNOX.	ros	79-82	tumor protein p53	Homo sapiens	37-40
30029680-11	2018	Moreover, the addition of a ROS scavenger reversed the p53 activation, POU3F2 down-regulation, and apoptosis induced by oxaliplatin in p53-wild-type cells.	ros	28-31	tumor protein p53	Homo sapiens	55-58
30029680-11	2018	Moreover, the addition of a ROS scavenger reversed the p53 activation, POU3F2 down-regulation, and apoptosis induced by oxaliplatin in p53-wild-type cells.	ros	28-31	POU class 3 homeobox 2	Homo sapiens	71-77
30029680-11	2018	Moreover, the addition of a ROS scavenger reversed the p53 activation, POU3F2 down-regulation, and apoptosis induced by oxaliplatin in p53-wild-type cells.	ros	28-31	tumor protein p53	Homo sapiens	135-138
30029680-12	2018	In the p53-null line, on the other hand, oxaliplatin treatment triggered less ROS generation and no p53 protein, such that POU3F2 and tNOX were not down-regulated and oxaliplatin-mediated cytotoxicity was attenuated.	ros	78-81	tumor protein p53	Homo sapiens	7-10
28478304-3	2018	In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFalpha, IL-1beta, IL-6 led to the irreversible DNA damage, persistent DDR activation, proliferation inhibition, reduction in cell growth and immune impairment.	ros	30-33	tumor necrosis factor	Homo sapiens	69-77
28478304-3	2018	In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFalpha, IL-1beta, IL-6 led to the irreversible DNA damage, persistent DDR activation, proliferation inhibition, reduction in cell growth and immune impairment.	ros	30-33	interleukin 1 beta	Homo sapiens	79-87
29061379-8	2018	These effects were more pronounced in FRTL-5 than in WRO, and the isoform beta1 was more potent in ROS production than the other two.	ros	99-102	potassium calcium-activated channel subfamily M regulatory beta subunit 1	Homo sapiens	74-79
28478304-3	2018	In turn, increased amounts of ROS/RNS and pro-inflammatory cytokines TNFalpha, IL-1beta, IL-6 led to the irreversible DNA damage, persistent DDR activation, proliferation inhibition, reduction in cell growth and immune impairment.	ros	30-33	interleukin 6	Homo sapiens	89-93
29061379-11	2018	Moreover, TGF-beta1 decreased glutathione peroxidase and mitochondrial superoxide dismutase mRNA expression and increased mitochondrial ROS in FRTL-5, but no in WRO.	ros	136-139	transforming growth factor beta 1	Homo sapiens	10-19
29061379-12	2018	Pretreatment with selenium increased glutathione peroxidase activity and decreased ROS production in WRO treated with TGF-beta isoforms.	ros	83-86	transforming growth factor beta 1	Homo sapiens	118-126
29061379-15	2018	CONCLUSION: TGF-beta disrupted the redox balance and increased ROS accumulation in both cell lines.	ros	63-66	transforming growth factor beta 1	Homo sapiens	12-20
29065700-8	2018	Hmox1+/+ MSCs but not fibroblasts retained low ROS levels even after prolonged incubation with 50 mumol/L hemin, although both cell types have a comparable Hmox1 expression and similarly increase its levels in response to hemin.	ros	47-50	heme oxygenase 1	Mus musculus	0-5
30034236-2	2018	Lapa is a novel therapeutic agent that generates ROS through the catalysis of the NAD(P) H:quinone oxidoreductase-1 (NQO1) enzyme which significantly facilitate the intracellular accumulation of the co-delivered DOX to overcome MDR in cancer cells.	ros	49-52	NAD(P)H quinone dehydrogenase 1	Homo sapiens	82-115
30034236-2	2018	Lapa is a novel therapeutic agent that generates ROS through the catalysis of the NAD(P) H:quinone oxidoreductase-1 (NQO1) enzyme which significantly facilitate the intracellular accumulation of the co-delivered DOX to overcome MDR in cancer cells.	ros	49-52	NAD(P)H quinone dehydrogenase 1	Homo sapiens	117-121
29680675-5	2018	Short-time (8-min) light irradiation produced non-lethal amount of ROS to disrupt the endosomal membranes and facilitate p53 gene release via degradation of TK-PEI, which collectively enhanced p53 expression levels toward anti-cancer gene therapy.	ros	67-70	tumor protein p53	Homo sapiens	121-124
29653364-8	2018	Overexpressed miR-20a reduced ROS generation under Ox-LDL treatment, and this effect was restored by forced expression of TLR4.	ros	30-33	microRNA 20a	Homo sapiens	14-21
29680675-5	2018	Short-time (8-min) light irradiation produced non-lethal amount of ROS to disrupt the endosomal membranes and facilitate p53 gene release via degradation of TK-PEI, which collectively enhanced p53 expression levels toward anti-cancer gene therapy.	ros	67-70	tumor protein p53	Homo sapiens	193-196
29680675-6	2018	Long-time (30-min) light irradiation at the post-transfection state generated lethal amount of ROS, which cooperatively killed cancer cells to strengthen p53 gene therapy.	ros	95-98	tumor protein p53	Homo sapiens	154-157
29663696-6	2018	In the work reported here, we examined the roles of the different beta-tubulin isotypes in response to glutamate/glycine treatment, and found that both betaII and betaIII bind to glutathione in the presence of ROS, especially betaIII.	ros	210-213	NLR family pyrin domain containing 3	Homo sapiens	152-170
29864915-10	2018	Furthermore, DHC reduced the levels of cellular NO and ROS via Nrf2 signaling pathways.	ros	55-58	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
29864924-9	2018	We also found that p38 and ERK inhibitors significantly antagonized the increase in cell viability and cellular ROS scavenging activity induced by NNLE.	ros	112-115	mitogen-activated protein kinase 1	Mus musculus	27-30
29663696-9	2018	In view of the high levels of betaII and betaIII expressed in the nervous system it is conceivable that these tubulin isotypes may use their sulfhydryl groups to scavenge ROS and protect neuronal cells against oxidative stress.	ros	171-174	NLR family pyrin domain containing 3	Homo sapiens	30-48
29230937-5	2018	Additionally, the transgenic plants reduced H2 O2 and O2 - accumulation under salinity, which could be due to up-regulation of ROS scavenger activities such as SOD, APX and CAT as well as CmHSP70, CmHSP90.	ros	127-130	catalase	Homo sapiens	173-176
29984607-12	2018	The formation of ROS and the expression of MDA5 (4.46 +- 0.01) and IREalpha (3.43 +- 0.00) mRNA and protein were increased and the expression of SOD-1 (0.28 +- 0.02) mRNA and protein was decreased ( P &lt; 0.05).	ros	17-20	superoxide dismutase 1, soluble	Mus musculus	145-150
29857913-8	2018	Additionally, latent HIV-1 reactivation via T cell receptor activation (a positive control in HIV-1 latency studies) involves PLCgamma1-mediated increases in intracellular Ca2+, an increase in ROS levels, and activation of kinases and transcription factors that are also critical for LTP.	ros	193-196	phospholipase C gamma 1	Homo sapiens	126-135
29124681-6	2018	In addition, QUIN (25 muM) and Hcy (30 muM) triggered ROS production, lipid peroxidation, diminished of Na+,K+-ATPase activity, and morphologic alterations, culminating in reduced neuronal viability by necrotic cell death.	ros	54-57	latexin	Homo sapiens	22-25
29124681-6	2018	In addition, QUIN (25 muM) and Hcy (30 muM) triggered ROS production, lipid peroxidation, diminished of Na+,K+-ATPase activity, and morphologic alterations, culminating in reduced neuronal viability by necrotic cell death.	ros	54-57	latexin	Homo sapiens	39-42
29684505-7	2018	This protective effect of SFN might be due to the activation of Nrf2-regulated antioxidant defense deficiencies in the DM mice, as SFN increased the Nrf2 nuclear accumulation and the downstream expression of the antioxidases HO-1 and NQO1 and reduced the levels of the reactive oxygen/nitrogen species (ROS/RNS) in DM mouse brains.	ros	303-306	nuclear factor, erythroid derived 2, like 2	Mus musculus	64-68
30046376-9	2018	Furthermore, OMA1/YME1L abnormal degradation was involved in the OPA1 dysfunction, and intervening OMA1/YME1L in H9C2 significantly alleviated mitochondrial fission, ultrastructure damage, and cell apoptosis induced by TNF-alpha and ROS.	ros	233-236	tumor necrosis factor	Mus musculus	219-228
30013474-6	2018	Curcumin (10 muM) decreased significantly (p &lt; 0.01) ROS concentration and TNF-alpha release in retinal pigmented epithelial cells and retinal endothelial cells, respectively.	ros	56-59	latexin	Homo sapiens	13-16
29898731-12	2018	PCa cells with mutated p53 (DU-145) and increased ROS showed significant reduction in the activation of pro-survival Akt pathway while Raf/MEK were activated in response to quercetin.	ros	50-53	AKT serine/threonine kinase 1	Homo sapiens	117-120
29898731-13	2018	PC-3 cells lacking p53 and PTEN with reduced ROS levels showed significant activation of Akt and NF-kappaB pathway.	ros	45-48	tumor protein p53	Homo sapiens	19-22
29898731-13	2018	PC-3 cells lacking p53 and PTEN with reduced ROS levels showed significant activation of Akt and NF-kappaB pathway.	ros	45-48	AKT serine/threonine kinase 1	Homo sapiens	89-92
29669207-3	2018	The outcomes revealed that ROS-inducing ZnPP PM demonstrated specificity for the in vitro and in vivo targeting of macrophages, elevated the level of ROS, and lowered STAT3 expression in BM-TAMs.	ros	27-30	signal transducer and activator of transcription 3	Homo sapiens	167-172
29702094-0	2018	ROS mediated EGFR/MEK/ERK/HIF-1alpha Loop Regulates Glucose metabolism in pancreatic cancer.	ros	0-3	epidermal growth factor receptor	Homo sapiens	13-17
29702094-0	2018	ROS mediated EGFR/MEK/ERK/HIF-1alpha Loop Regulates Glucose metabolism in pancreatic cancer.	ros	0-3	mitogen-activated protein kinase kinase 7	Homo sapiens	18-21
29702094-0	2018	ROS mediated EGFR/MEK/ERK/HIF-1alpha Loop Regulates Glucose metabolism in pancreatic cancer.	ros	0-3	mitogen-activated protein kinase 1	Homo sapiens	22-25
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	epidermal growth factor receptor	Homo sapiens	36-40
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	mitogen-activated protein kinase kinase 7	Homo sapiens	41-44
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	mitogen-activated protein kinase 1	Homo sapiens	45-48
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	epidermal growth factor receptor	Homo sapiens	210-214
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	mitogen-activated protein kinase kinase 7	Homo sapiens	215-218
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	mitogen-activated protein kinase 1	Homo sapiens	219-222
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	23-26	epidermal growth factor receptor	Homo sapiens	210-214
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	epidermal growth factor receptor	Homo sapiens	36-40
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	mitogen-activated protein kinase kinase 7	Homo sapiens	41-44
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	mitogen-activated protein kinase 1	Homo sapiens	45-48
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
29733381-7	2018	Our functional studies highlighted the importance of the HSF1-FOXO3-SOD2/CAT/GADD45A cascade in cellular stress response and survival by promoting ROS detoxification, redox balance and DNA repair.	ros	147-150	forkhead box O3	Homo sapiens	62-67
29733381-7	2018	Our functional studies highlighted the importance of the HSF1-FOXO3-SOD2/CAT/GADD45A cascade in cellular stress response and survival by promoting ROS detoxification, redox balance and DNA repair.	ros	147-150	catalase	Homo sapiens	73-76
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
29866132-9	2018	Mechanistically, the combined therapy significantly induced cancer cell apoptosis and autophagy, which were mediated by ROS regulated PKA and ERK signaling.	ros	120-123	mitogen-activated protein kinase 1	Homo sapiens	142-145
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	epidermal growth factor receptor	Homo sapiens	210-214
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	epidermal growth factor receptor	Homo sapiens	210-214
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	epidermal growth factor receptor	Homo sapiens	36-40
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	mitogen-activated protein kinase kinase 7	Homo sapiens	41-44
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	mitogen-activated protein kinase 1	Homo sapiens	45-48
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	epidermal growth factor receptor	Homo sapiens	210-214
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	hypoxia inducible factor 1 subunit alpha	Homo sapiens	157-167
29702094-3	2018	The data suggests that ROS mediated EGFR/MEK/ERK/HIF-1alpha loop is activated in high glucose metabolic samples both in vitro and in vivo: The increasing of HIF-1alpha expression is controlled by activation of EGFR/MEK/ERK pathway in hypoxia condition, HIF-1alpha inhibits excessive release of ROS, the reduction of ROS further activates EGFR to form a positive feedback loop.	ros	294-297	epidermal growth factor receptor	Homo sapiens	210-214
29753072-7	2018	In PM2.5-exposed BEAS-2B and H9C2 cells, inhibition of AMPK activity significantly decreased cell viability and Prdx5 expression, and increased the intracellular ROS and p-NF-kappaB levels.	ros	162-165	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	55-59
29842900-7	2018	Evidences showed that the mutant hSOD1 resulted in the increased oxidative stress, abnormal antioxidant signaling and pathological behaviors in motor performance and survival compared with non-mutant hSOD1 models, treatment with LA improved motor activity and survival in transgenic flies, prevented NSC34 cells from mutant hSOD1 or H2O2 induced decreased antioxidant enzymes as well as increased ROS levels.	ros	397-400	superoxide dismutase 1	Homo sapiens	33-38
29653689-11	2018	In conclusion, this study shows that intracellular ROS, not extracellular ROS such as H2O2, plays a crucial role in facilitating platelet aggregation via LPS/TLR4 pathway, and this process was involved in AKT, PKC and p38 phosphorylation but not cGMP/cAMP pathway.	ros	51-54	mitogen-activated protein kinase 14	Homo sapiens	218-221
29477336-13	2018	These results suggest that some impairment in the regulation mechanism of FoxO-1a phosphorylation is responsible for abnormal catalase expression and that a significant decrease in the level of catalase with aging decisively affects the metabolic balance of ROS; thus, ROS that cannot be metabolized contributes to the accelerated aging of SAMP10 mice.	ros	258-261	catalase	Mus musculus	194-202
29477336-13	2018	These results suggest that some impairment in the regulation mechanism of FoxO-1a phosphorylation is responsible for abnormal catalase expression and that a significant decrease in the level of catalase with aging decisively affects the metabolic balance of ROS; thus, ROS that cannot be metabolized contributes to the accelerated aging of SAMP10 mice.	ros	269-272	catalase	Mus musculus	194-202
29620052-6	2018	IL-1beta treatment increased cholesterol accumulation in HK-2 cells, leading to greatly increased ROS production, ECM protein expression levels, which was accompanied by the upregulated expression levels of proteins in the CXCL16 pathway.	ros	98-101	interleukin 1 beta	Mus musculus	0-8
29444458-10	2018	Lower cell viability, higher apoptosis, and more ROS were detected upon treatment of cells with glycated insulin.	ros	49-52	insulin	Homo sapiens	105-112
29444458-11	2018	Finally, glycated insulin led to increased Lucifer yellow and FITC-dextran transportation across the BBB model which could result from ROS producing and apoptosis-inducing activities of AGE-insulin.	ros	135-138	insulin	Homo sapiens	18-25
29542272-3	2018	METHODS: ROS formation by Calu-3 human airway cells was studied by measuring dihydrorhodamine 123 oxidation after activation by polyinosinic:polycytidylic acid (to activate TLR3), CL097 (to activate TLR7), a natural mixture of HDM allergens, or BzATP.	ros	9-12	toll like receptor 7	Homo sapiens	199-203
29649591-4	2018	Based on detailed studies of oxidative stress parameters and transforming growth factor-beta1 (TGF-beta1), we demonstrated they owned the antioxidant and anti-inflammatory functions for the modulation of ROS-mediated inflammation process.	ros	204-207	transforming growth factor beta 1	Homo sapiens	61-93
29649591-4	2018	Based on detailed studies of oxidative stress parameters and transforming growth factor-beta1 (TGF-beta1), we demonstrated they owned the antioxidant and anti-inflammatory functions for the modulation of ROS-mediated inflammation process.	ros	204-207	transforming growth factor beta 1	Homo sapiens	95-104
29684849-3	2018	Txnip modulates inflammatory pathway (via ROS production and NLRP3 inflammasome activity) and apoptotic pathway (via mTOR pathway).	ros	42-45	thioredoxin interacting protein	Homo sapiens	0-5
29348462-8	2018	Administration of PL and APR-246 significantly suppresses GSTP1 activity, resulting in the accumulation of ROS, depletion of GSH, elevation of GSSG, and DNA damage.	ros	107-110	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	25-28
29348462-11	2018	Taken together, our data suggest that HNSCC cells are selectively sensitive to the combination of PL and APR-246 due to a remarkably synergistic effect of the co-treatment in the induction of ROS by suppression of GSTP1.	ros	192-195	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	105-108
29524841-8	2018	In addition, the level of intracellular ROS was significantly increased in H9C2 cells treated by DOX after miR-140-5p mimic transfection, as well as the down-regulated expression levels of Nrf2 and Sirt2, which were markedly reversed by dioscin.	ros	40-43	microRNA 140	Rattus norvegicus	107-114
29524841-8	2018	In addition, the level of intracellular ROS was significantly increased in H9C2 cells treated by DOX after miR-140-5p mimic transfection, as well as the down-regulated expression levels of Nrf2 and Sirt2, which were markedly reversed by dioscin.	ros	40-43	NFE2 like bZIP transcription factor 2	Rattus norvegicus	189-193
29875661-7	2018	Meanwhile, Kdm2b, an H3K36me2-specific demethylase effectively suppressed ROS generation, was also notably suppressed by shikonin treatment.	ros	74-77	lysine (K)-specific demethylase 2B	Mus musculus	11-16
29950247-2	2018	The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS.	ros	71-74	NLR family pyrin domain containing 3	Homo sapiens	126-131
29754474-11	2018	Therefore, OMT-induced injury in L02 cells was related to ROS mediated p-JNK and ER stress induction.	ros	58-61	mitogen-activated protein kinase 8	Homo sapiens	73-76
29790558-8	2018	EPR spin-trapping experiments show that the C60@lysozyme hybrid produces ROS following both type I and type II mechanisms.	ros	73-76	lysozyme	Homo sapiens	44-56
29795387-7	2018	Results showed that OGG1-BER further increases the levels of ROS-induced DNA damage by generating repair intermediates, leading to PARP1 overactivation and cell death.	ros	61-64	poly(ADP-ribose) polymerase 1	Homo sapiens	131-136
29766185-0	2018	The curcumin derivative WZ35 activates ROS-dependent JNK to suppress hepatocellular carcinoma metastasis.	ros	39-42	mitogen-activated protein kinase 8	Homo sapiens	53-56
29766185-10	2018	In addition, our data show that WZ35 promotes ROS-dependent JNK activation that is essential for WZ35-caused cell metastasis suppression.	ros	46-49	mitogen-activated protein kinase 8	Homo sapiens	60-63
29408424-4	2018	Mediated by NIR light, Her2-I&amp;D-LSL was proved to generate sufficient ROS to realize PDT, which then triggered the release of DOX for combined chemotherapy.	ros	74-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
29791511-11	2018	In turn, protection conferred by IFNgamma against melioidosis was dependent on generation of ROS through the NADPH oxidase but independent of induction of caspase-11.	ros	93-96	interferon gamma	Mus musculus	33-41
29861832-11	2018	In diabetic mice, inhibition of TLR4 could reverse the decreased expression of PGC-1alpha, increased expression of cytochrome C and cleaved caspase-3, mitochondrial dysfunction and deformation, increased accumulation of ROS, and activation of tubular cell apoptosis.	ros	220-223	toll-like receptor 4	Mus musculus	32-36
29753331-1	2018	TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway.	ros	63-66	tumor protein p53	Homo sapiens	11-14
29655083-0	2018	Design, synthesis, anti-lung cancer activity, and chemosensitization of tumor-selective MCACs based on ROS-mediated JNK pathway activation and NF-kappaB pathway inhibition.	ros	103-106	mitogen-activated protein kinase 8	Homo sapiens	116-119
28898138-7	2018	Nrf2 is involved with chondrogenesis, osteoblastogenesis, prostaglandin secretion and ROS production in RA.	ros	86-89	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
29655083-6	2018	Further, 5B was found to exert anti-tumor effects through ROS-mediated activation of JNK pathway and inhibition of NF-kappaB pathway.	ros	58-61	mitogen-activated protein kinase 8	Homo sapiens	85-88
29571736-0	2018	Liraglutide attenuates NLRP3 inflammasome-dependent pyroptosis via regulating SIRT1/NOX4/ROS pathway in H9c2 cells.	ros	89-92	NLR family, pyrin domain containing 3	Rattus norvegicus	23-28
29571736-9	2018	Our results uncovered the anti-pyroptosis role of liraglutide in TNF-alpha and hypoxia-stimulated H9c2 cells, which was associated with SIRT1/NOX4/ROS pathway.	ros	147-150	tumor necrosis factor	Rattus norvegicus	65-74
29571736-9	2018	Our results uncovered the anti-pyroptosis role of liraglutide in TNF-alpha and hypoxia-stimulated H9c2 cells, which was associated with SIRT1/NOX4/ROS pathway.	ros	147-150	sirtuin 1	Rattus norvegicus	136-141
29770114-10	2018	Furthermore, we found artocarpin-induced ROS production in mitochondria is associated with Akt- and ERK1/2 activation.	ros	41-44	AKT serine/threonine kinase 1	Homo sapiens	91-94
29720572-5	2018	Furthermore, endospanin-2, but not endospanin-1, overexpression decreases muscle mitochondrial ROS production, induces fast-to-slow fiber-type switch, increases skeletal muscle glycogen content, and improves glucose homeostasis, ultimately promoting running endurance capacity.	ros	95-98	leptin receptor overlapping transcript-like 1	Mus musculus	13-25
29720572-6	2018	In line, endospanin-2-/- mice display higher lipid peroxidation levels, increased mitochondrial ROS production under mitochondrial stress, decreased ERK phosphorylation, and reduced endurance capacity.	ros	96-99	leptin receptor overlapping transcript-like 1	Mus musculus	9-21
29716526-11	2018	In vitro, NKX2.5 overexpression reduces the expression of thyroid differentiation markers and increases ROS production.	ros	104-107	NK2 homeobox 5	Homo sapiens	10-16
29770114-10	2018	Furthermore, we found artocarpin-induced ROS production in mitochondria is associated with Akt- and ERK1/2 activation.	ros	41-44	mitogen-activated protein kinase 3	Homo sapiens	100-106
29770114-11	2018	After treatment with artocarpin, ROS causes PI3K/Akt/ERK1/2-induced cell death of these tumor cells.	ros	33-36	AKT serine/threonine kinase 1	Homo sapiens	49-52
29770114-11	2018	After treatment with artocarpin, ROS causes PI3K/Akt/ERK1/2-induced cell death of these tumor cells.	ros	33-36	mitogen-activated protein kinase 3	Homo sapiens	53-59
28906145-4	2018	This was achieved by modulating MDA, GST, IL-1beta, IL-6 and reduced the interference of ROS with IGF-1 and NGF stimulating the PI3K/AKT-signaling.	ros	89-92	insulin like growth factor 1	Homo sapiens	98-103
29720213-11	2018	ROS was required for PM2.5-induced IL-1beta production and NLRP3 inflammasome activation in oAbeta-stimulated microglia.	ros	0-3	NLR family pyrin domain containing 3	Homo sapiens	59-64
29720213-13	2018	CONCLUSIONS: For the first time, these results suggested that the effects of PM2.5 under AD context were possibly mediated by NLRP3 inflammasome activation, which was triggered by ROS.	ros	180-183	NLR family pyrin domain containing 3	Homo sapiens	126-131
29951499-4	2018	In brain, as an endogenous stimulator, extracellular Abeta deposition activates innate immunity through binding to the pattern recognition receptors (PRR), thus leading to the production and release of substantial inflammatory mediators (NO and ROS) and cytokines (IL-1beta, IL-10, IL-33 and TNF-alpha) contributing to the development of AD.	ros	245-248	amyloid beta precursor protein	Homo sapiens	53-58
28906145-4	2018	This was achieved by modulating MDA, GST, IL-1beta, IL-6 and reduced the interference of ROS with IGF-1 and NGF stimulating the PI3K/AKT-signaling.	ros	89-92	AKT serine/threonine kinase 1	Homo sapiens	133-136
29661910-4	2018	In mice, p38gamma/p38delta deficiency protects against C. albicans infection by increasing ROS and iNOS production and thus the antifungal capacity of neutrophils and macrophages, and by decreasing the hyper-inflammation that leads to severe host damage.	ros	91-94	mitogen-activated protein kinase 12	Mus musculus	9-17
29725369-9	2018	EP upregulated CYP2E1, downregulated PPAR-alpha, nuclear factor 2 (Nrf2) and very-low density lipoprotein receptor (VLDLR), positively regulated the CYP2E1-PPAR-alpha-ROS signaling pathway and negatively regulated the ROS-Nrf2-VLDLR signaling pathway.	ros	167-170	peroxisome proliferator activated receptor alpha	Mus musculus	156-166
29589770-4	2018	Key requirement for the involvement of the redox modifications in RONS signalling including ROS-MAPK, ROS-PI3K/Akt, and RNS-TNF-alpha/NF-kB signalling is their specificity provided by a residue microenvironment and reaction kinetics.	ros	102-105	AKT serine/threonine kinase 1	Homo sapiens	111-114
29211299-7	2018	The suppression on T cell proliferation and IFN-gamma production was reversed by ROS inhibitor and Arginase inhibitor.	ros	81-84	interferon gamma	Homo sapiens	44-53
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	fucosyltransferase 4	Homo sapiens	46-50
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	fucosyltransferase 4	Homo sapiens	79-83
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	fucosyltransferase 4	Homo sapiens	79-83
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	fucosyltransferase 4	Homo sapiens	79-83
29211299-11	2018	Above all, LOX-1+  CD15+ PMN-MDSC were elevated in HCC patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress.	ros	108-111	fucosyltransferase 4	Homo sapiens	19-23
29578555-4	2018	In vitro data show that TMPC has specific HER2 selective interactions, and ROS generation ability upon laser irradiation induces significant cell death in HER2-positive breast cancer cells.	ros	75-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	155-159
29604305-8	2018	The current results suggest that the increase of ROS production by PVP-AgNPs stimulated SOD and CAT activity, as well as IRS-1, AKT, mTOR, p53, p21 and caspase 3 as protective mechanisms of cell survival and preserve DNA fidelity.	ros	49-52	insulin receptor substrate 1	Rattus norvegicus	121-126
30081998-53	2018	CONCLUSION: A large amount ROS was produced during DMF metabolized by CYP2E1, which can cause oxidative stress and lead to inflammation.	ros	27-30	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	70-76
29395579-8	2018	Furthermore t-CA-induced Nrf2 translocation is mediated through PKC, AMPK, CKII or ROS signaling cascades.	ros	83-86	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
29304479-8	2018	In addition, the levels of intracellular ROS were significantly increased or decreased in H9C2 cells treated with DOX after miR-140-5p mimic or miR-140-5p inhibitor transfection, respectively, as well as the changed expression levels of Nrf2 and Sirt2.	ros	41-44	NFE2 like bZIP transcription factor 2	Rattus norvegicus	237-241
29584621-5	2018	This mitochondrial source of ROS contributes to NF-kappaB-driven production of IL-1beta and TNF-alpha, which promote neutrophil recruitment.	ros	29-32	interleukin 1 beta	Homo sapiens	79-87
29584621-5	2018	This mitochondrial source of ROS contributes to NF-kappaB-driven production of IL-1beta and TNF-alpha, which promote neutrophil recruitment.	ros	29-32	tumor necrosis factor	Homo sapiens	92-101
29565448-3	2018	Our previous study revealed that kaempferol triggered apoptosis in human umbilical vein endothelial cells (HUVECs) by ROS-mediated p53/ATM/death receptor signaling.	ros	118-121	tumor protein p53	Homo sapiens	131-134
29565452-8	2018	Furthermore, pretreatment of Caki cells with ROS scavengers (N-acetylcysteine and glutathione) prevented the downregulation of cFLIP(L), the upregulation of cFLIP(S) and apoptosis induced by FasL.	ros	45-48	CASP8 and FADD like apoptosis regulator	Homo sapiens	127-135
29565452-8	2018	Furthermore, pretreatment of Caki cells with ROS scavengers (N-acetylcysteine and glutathione) prevented the downregulation of cFLIP(L), the upregulation of cFLIP(S) and apoptosis induced by FasL.	ros	45-48	CASP8 and FADD like apoptosis regulator	Homo sapiens	127-132
29565452-9	2018	Collectively, these data indicated that a novel pathway of cFLIP(L)/(S) differential expression pattern was associated with FasL-induced apoptosis and modulated by ROS generation.	ros	164-167	CASP8 and FADD like apoptosis regulator	Homo sapiens	59-64
29216542-5	2018	Using wild type D3 and HO-1 knockout ESCs in the 3-dimensional embryoid body (EB) differentiation model, we showed that at an early time point during EB development, an absence of HO-1 led to enhanced ROS level, concomitant with increased expressions of master mesodermal regulator brachyury and endodermal marker GATA6.	ros	201-204	heme oxygenase 1	Mus musculus	180-184
29220696-0	2018	Cardioprotection of CAPE-oNO2 against myocardial ischemia/reperfusion induced ROS generation via regulating the SIRT1/eNOS/NF-kappaB pathway in vivo and in vitro.	ros	78-81	sirtuin 1	Rattus norvegicus	112-117
29220696-8	2018	In vitro, they could inhibit HR-induced H9c2 cell apoptosis and ROS generation by activating SIRT1/eNOS pathway and inhabiting NF-kappaB expression.	ros	64-67	sirtuin 1	Rattus norvegicus	93-98
29649125-6	2018	The formation of ROS is closely related to the activation of the stress-activated kinases, JNK and p38, while SP600125 (SP, JNK inhibitor) and SB203580 (SB, p38 inhibitor) pretreatment inhibited the generation of ROS.	ros	17-20	mitogen-activated protein kinase 8	Homo sapiens	91-94
29849862-9	2018	CaOx-induced ROS and stone-related protein upregulation were mediated by the Ang II/AT1R signaling pathway.	ros	13-16	angiotensinogen	Rattus norvegicus	77-83
29649125-6	2018	The formation of ROS is closely related to the activation of the stress-activated kinases, JNK and p38, while SP600125 (SP, JNK inhibitor) and SB203580 (SB, p38 inhibitor) pretreatment inhibited the generation of ROS.	ros	17-20	mitogen-activated protein kinase 14	Homo sapiens	99-102
29649125-6	2018	The formation of ROS is closely related to the activation of the stress-activated kinases, JNK and p38, while SP600125 (SP, JNK inhibitor) and SB203580 (SB, p38 inhibitor) pretreatment inhibited the generation of ROS.	ros	17-20	mitogen-activated protein kinase 14	Homo sapiens	157-160
29335220-4	2018	In turn, excessive ROS induced caspase-3-dependent PKCdelta activation and stimulated NF-kappaB p65 nuclear translocation, resulting in inflammation in the mouse hippocampus.	ros	19-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-95
29615659-5	2018	Obesity was associated with pro-inflammatory activation of CD14+ phagocytes from adipose tissue in female, but not in male rats, which was demonstrated by decreased phagocytosis activity along with increased ROS generation.	ros	208-211	CD14 molecule	Rattus norvegicus	59-63
29432786-8	2018	ROS formation due to OA-Alb treatment was only slightly altered in LMH cells, indicating an intact antioxidant defense system of the cells.	ros	0-3	albumin	Homo sapiens	24-27
29896416-8	2018	After addition of the autophagy inhibitor 3-MA, the protective effect of SIRT3 diminished: the cell viability decreased, while the apoptosis rate increased; alpha-synuclein accumulation enhanced; ROS production increased; antioxidants levels, including SOD and GSH, decreased; and MMP collapsed.	ros	196-199	sirtuin 3	Homo sapiens	73-78
29468481-6	2018	In addition, LCA mediated apoptotic cell death was confirmed by MMP loss, increased ROS, cleaved PARP and decreased pro-caspase3.	ros	84-87	clathrin light chain A	Homo sapiens	13-16
29452237-4	2018	The ROS scavenger MnTMPyP was able to prevent the increase of both VEGF expression and capillary length induced by chlordecone.	ros	4-7	vascular endothelial growth factor A	Homo sapiens	67-71
29306019-10	2018	HIF1alpha can stimulate some glycolysis-associated genes and regulate the ATP and ROS generations.	ros	82-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-9
29421327-7	2018	Intracellular ROS accumulation arouses ER stress, initiating PERK dependent UPR and inducing the downstream signal Nrf2 and ATF4 auto-phosphorylation.	ros	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
29446486-0	2018	Interleukin-17A participates in podocyte injury by inducing IL-1beta secretion through ROS-NLRP3 inflammasome-caspase-1 pathway.	ros	87-90	interleukin 1 beta	Homo sapiens	60-68
29478373-12	2018	We also confirmed that fractionated AEF1 (new radiolytic peak) induce the cell death, migration, an increase of sub-G1 phase and cytochrome c in a ROS-dependent manner.	ros	147-150	cytochrome c, somatic	Homo sapiens	129-141
29524019-5	2018	Importantly, we provide evidence that defective CFTR and NOX/GR activity imbalance both contribute to NADPH and GSH level decrease and ROS overproduction in CF cells.	ros	135-138	CF transmembrane conductance regulator	Homo sapiens	48-52
29367760-0	2018	ROS release by PPARbeta/delta-null fibroblasts reduces tumor load through epithelial antioxidant response.	ros	0-3	peroxisome proliferator activator receptor delta	Mus musculus	15-23
29367760-9	2018	Therefore, our results establish a role for fibroblast PPARbeta/delta in epithelial-mesenchymal communication for ROS homeostasis.	ros	114-117	peroxisome proliferator activator receptor delta	Mus musculus	55-63
29446486-0	2018	Interleukin-17A participates in podocyte injury by inducing IL-1beta secretion through ROS-NLRP3 inflammasome-caspase-1 pathway.	ros	87-90	NLR family pyrin domain containing 3	Homo sapiens	91-96
29446486-0	2018	Interleukin-17A participates in podocyte injury by inducing IL-1beta secretion through ROS-NLRP3 inflammasome-caspase-1 pathway.	ros	87-90	caspase 1	Homo sapiens	110-119
29446486-8	2018	Blockade of intracellular ROS or inhibition of caspase-1 prevented activation of the NLRP3 inflammasome, thereby restoring podocyte morphology.	ros	26-29	NLR family pyrin domain containing 3	Homo sapiens	85-90
29428410-8	2018	Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), while ROS production dramatically decreased.	ros	311-314	NFE2 like bZIP transcription factor 2	Rattus norvegicus	63-67
29367253-6	2018	We also found various previously unknown interactions among the AiV proteins (2B, 2BC, 2C, 3A, and 3AB), ACBD3, OSBP, VAP-A/B, and SAC1, and the interactions were suggested to be involved in recruiting the component proteins to AiV ROs.	ros	232-235	oxysterol binding protein	Homo sapiens	112-116
29367253-6	2018	We also found various previously unknown interactions among the AiV proteins (2B, 2BC, 2C, 3A, and 3AB), ACBD3, OSBP, VAP-A/B, and SAC1, and the interactions were suggested to be involved in recruiting the component proteins to AiV ROs.	ros	232-235	VAMP associated protein A	Homo sapiens	118-125
29325990-11	2018	In contrast, JAZ7 overexpression plants were much different, and proteomic analysis of the JAZ7 overexpression plants under Pst DC3000 infection revealed that JAZ7 may regulate plant immunity via ROS modulation, energy balance and glucosinolate biosynthesis.	ros	196-199	jasmonate-zim-domain protein 7	Arabidopsis thaliana	91-95
29325990-11	2018	In contrast, JAZ7 overexpression plants were much different, and proteomic analysis of the JAZ7 overexpression plants under Pst DC3000 infection revealed that JAZ7 may regulate plant immunity via ROS modulation, energy balance and glucosinolate biosynthesis.	ros	196-199	jasmonate-zim-domain protein 7	Arabidopsis thaliana	91-95
29530027-11	2018	This was followed by the in vitro evaluation of the ability of KGF, CSF and CCF to inhibit lipopolysaccharides (LPS) induced overproduction of various pro-inflammatory mediators (NO, ROS and IL1beta, TNFalpha, IL6, NF-kB cytokines).	ros	183-186	fibroblast growth factor 7	Homo sapiens	63-66
29576052-11	2018	Taken together, NOR ameliorated TNBS-induced colitis in mice through inhibiting NLRP3 inflammasome activation via regulating AhR/Nrf2/ROS signaling pathway.	ros	134-137	aryl-hydrocarbon receptor	Mus musculus	125-128
29576052-11	2018	Taken together, NOR ameliorated TNBS-induced colitis in mice through inhibiting NLRP3 inflammasome activation via regulating AhR/Nrf2/ROS signaling pathway.	ros	134-137	nuclear factor, erythroid derived 2, like 2	Mus musculus	129-133
29395479-7	2018	The results suggest that low levels of Apaf-1 as an adaptor protein might be considered as a possible regulatory barrier by which differentiating cells control cell death upon rise in ROS production and cytochrome c release from mitochondria.	ros	184-187	apoptotic peptidase activating factor 1	Homo sapiens	39-45
29421237-11	2018	Moreover, Nfe2l1(L)-KD cells were found to have elevated levels of intracellular ROS, but macrophage M1 polarization induced by Nfe2l1(L) silence was independent of ROS accumulation.	ros	81-84	NFE2 like bZIP transcription factor 1	Homo sapiens	10-16
29732286-3	2018	In response, the CSMC begin to upregulate the inducible nitric oxide synthase (iNOS) enzyme presumably to achieve high levels of nitric oxide (NO) used to combat ROS.	ros	162-165	nitric oxide synthase 2	Homo sapiens	46-77
29732286-3	2018	In response, the CSMC begin to upregulate the inducible nitric oxide synthase (iNOS) enzyme presumably to achieve high levels of nitric oxide (NO) used to combat ROS.	ros	162-165	nitric oxide synthase 2	Homo sapiens	79-83
29367253-7	2018	Importantly, the OSBP-2B interaction enabled PI4P-independent recruitment of OSBP to AiV ROs, indicating preferential recruitment of OSBP among PI4P-binding proteins.	ros	89-92	oxysterol binding protein	Homo sapiens	17-21
29367253-7	2018	Importantly, the OSBP-2B interaction enabled PI4P-independent recruitment of OSBP to AiV ROs, indicating preferential recruitment of OSBP among PI4P-binding proteins.	ros	89-92	oxysterol binding protein	Homo sapiens	77-81
29367253-7	2018	Importantly, the OSBP-2B interaction enabled PI4P-independent recruitment of OSBP to AiV ROs, indicating preferential recruitment of OSBP among PI4P-binding proteins.	ros	89-92	oxysterol binding protein	Homo sapiens	77-81
29367253-9	2018	Cholesterol was accumulated at AiV ROs, and inhibition of OSBP-mediated cholesterol transfer impaired cholesterol accumulation and AiV RNA replication.	ros	35-38	oxysterol binding protein	Homo sapiens	58-62
29547569-7	2018	In contrast, melatonin upregulated UCP2 expression and protected the cells from the changes in morphology, mitochondrial membrane potential loss, mitochondrial Ca2+ overload, the opening of mitochondrial permeability transition pore, and subsequent increased ROS generation as well as ATP reduction.	ros	259-262	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	35-39
29331761-7	2018	In addition, WFA reduced the ROS generation, mitochondrial depolarization and apoptosis induced by inflammatory cytokines IL-1beta and TNF-alpha.	ros	29-32	interleukin 1 beta	Rattus norvegicus	122-130
29331761-7	2018	In addition, WFA reduced the ROS generation, mitochondrial depolarization and apoptosis induced by inflammatory cytokines IL-1beta and TNF-alpha.	ros	29-32	tumor necrosis factor	Rattus norvegicus	135-144
29428410-8	2018	Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), while ROS production dramatically decreased.	ros	311-314	heme oxygenase 1	Mus musculus	228-232
29428410-8	2018	Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), while ROS production dramatically decreased.	ros	311-314	tumor necrosis factor	Mus musculus	277-286
29428410-8	2018	Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), while ROS production dramatically decreased.	ros	311-314	interleukin 1 beta	Mus musculus	288-296
29428410-8	2018	Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), while ROS production dramatically decreased.	ros	311-314	interleukin 6	Mus musculus	298-302
29155206-7	2018	In fact, reduction of Cx43 translocation on mitochondria increases mitochondrial ROS production, cytosolic and mitochondrial calcium overload and mitochondrial membrane depolarization, thus resulting in an increase of the triggering apoptotic pathway.	ros	81-84	gap junction protein, alpha 1	Rattus norvegicus	22-26
29264745-7	2018	We also report that IL-1beta interferes with thermogenesis via oxidative stress stimulation and mitochondrial dysfunction as we observed a statistically significant increase in ROS production, decrease in SOD enzyme activity, and increase in mitochondrial depolarization in adipocytes treated with IL-1beta.	ros	177-180	interleukin 1 beta	Homo sapiens	20-28
29363860-7	2018	These data suggest that ACE-EPCs-EXs have better protective effects on H/R injury in ageing ECs which could be through their carried miR-18a and subsequently down-regulating the Nox2/ROS pathway.	ros	183-186	angiotensin I converting enzyme	Homo sapiens	24-27
28942242-5	2018	Through the upregulation of VEGF, NO, ROS and PDGF, HIF-1 is able to cause endothelial cell dysfunction, proliferation, angiogenesis and inflammation.	ros	38-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-57
29414312-8	2018	Further investigation suggested that SIP1 improved Arabidopsis tolerance to salt stress by reducing the ROS accumulation.	ros	104-107	Raffinose synthase family protein	Arabidopsis thaliana	37-41
29119225-13	2018	PLM also inhibited cytoskeletal reorganization in migrating RA FLS and decreased TNF-alpha-induced intracellular ROS production.	ros	113-116	tumor necrosis factor	Homo sapiens	81-90
29431732-6	2018	Upregulation of p53 in turn disrupted the pentose phosphate pathway, leading to excessive ROS production and dormant TRC death.	ros	90-93	tumor protein p53	Homo sapiens	16-19
28357805-7	2018	By activating NF-kappaB, LPS increases ROS and NO levels that spontaneously react to form peroxynitrite, thus leading to protein nitration.	ros	39-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	14-23
29164624-5	2018	In this study, we found that STE (12.5-50 mug mL-1 ) treatment significantly inhibited UVB-induced MMP-1, MMP-2 and MMP-3 expression, concomitant with a downregulation of intracellular ROS generation.	ros	185-188	2'-5' oligoadenylate synthetase 1B	Mus musculus	46-50
29444128-6	2018	It could have attenuated TNF-alpha and LPS-induced inflammatory responses by suppressing ROS activation.	ros	89-92	tumor necrosis factor	Homo sapiens	25-34
29339024-5	2018	Human chondrocytes treated with IL-1beta resulted in robust Nrf2/ARE reporter activity, which was inhibited by pretreatment with antioxidants indicating that Nrf2 activity was due to IL-1beta-induced ROS generation.	ros	200-203	interleukin 1 beta	Homo sapiens	32-40
29339024-5	2018	Human chondrocytes treated with IL-1beta resulted in robust Nrf2/ARE reporter activity, which was inhibited by pretreatment with antioxidants indicating that Nrf2 activity was due to IL-1beta-induced ROS generation.	ros	200-203	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
29339024-5	2018	Human chondrocytes treated with IL-1beta resulted in robust Nrf2/ARE reporter activity, which was inhibited by pretreatment with antioxidants indicating that Nrf2 activity was due to IL-1beta-induced ROS generation.	ros	200-203	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
29339024-5	2018	Human chondrocytes treated with IL-1beta resulted in robust Nrf2/ARE reporter activity, which was inhibited by pretreatment with antioxidants indicating that Nrf2 activity was due to IL-1beta-induced ROS generation.	ros	200-203	interleukin 1 beta	Homo sapiens	183-191
29339024-6	2018	Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as IL-1beta-induced ROS levels in OA chondrocytes.	ros	87-90	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
29339024-6	2018	Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as IL-1beta-induced ROS levels in OA chondrocytes.	ros	87-90	interleukin 1 beta	Homo sapiens	56-64
29339024-6	2018	Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as IL-1beta-induced ROS levels in OA chondrocytes.	ros	174-177	NFE2 like bZIP transcription factor 2	Homo sapiens	22-26
29339024-6	2018	Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as IL-1beta-induced ROS levels in OA chondrocytes.	ros	174-177	NFE2 like bZIP transcription factor 2	Homo sapiens	97-101
29339024-6	2018	Ectopic expression of Nrf2 significantly suppressed the IL-1beta-induced generation of ROS while Nrf2 knockdown significantly increased the basal as well as IL-1beta-induced ROS levels in OA chondrocytes.	ros	174-177	interleukin 1 beta	Homo sapiens	157-165
29339024-7	2018	Further, Nrf2 activation significantly inhibited the IL-1beta-induced activation of extrinsic and intrinsic apoptotic pathways as determined by inhibition of DNA fragmentation, activation of Caspase-3,-8,-9, cleavage of PARP, release of cytochrome-c, suppression of mitochondrial dysfunction and mitochondrial ROS production in OA chondrocytes.	ros	310-313	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
29339024-7	2018	Further, Nrf2 activation significantly inhibited the IL-1beta-induced activation of extrinsic and intrinsic apoptotic pathways as determined by inhibition of DNA fragmentation, activation of Caspase-3,-8,-9, cleavage of PARP, release of cytochrome-c, suppression of mitochondrial dysfunction and mitochondrial ROS production in OA chondrocytes.	ros	310-313	interleukin 1 beta	Homo sapiens	53-61
33500892-1	2018	This paper presents some recent developments in YARP middleware, aimed to improve its integration with ROS.	ros	103-106	gon-4 like	Homo sapiens	48-52
33500892-3	2018	A novel set of YARP companion modules, which provide basic navigation functionalities for robots unable to run ROS, is also presented.	ros	111-114	gon-4 like	Homo sapiens	15-19
29452639-3	2018	Mitochondrial MDM2 represses the transcription of NADH-dehydrogenase 6 (MT-ND6) in vitro and in vivo, impinging on respiratory complex I activity and enhancing mitochondrial ROS production.	ros	174-177	NADH dehydrogenase 6, mitochondrial	Mus musculus	72-78
29854032-7	2018	The inhibiter of methyltransferase EZH2, EPZ005687 significantly inhibits the development of TAC-induced PAH in an EZH2-SOD1-ROS dependent manner.	ros	125-128	superoxide dismutase 1, soluble	Mus musculus	120-124
29670923-9	2018	We also established that LL-37 acts as a powerful inducer of CCL3 and ROS generation.	ros	70-73	cathelicidin antimicrobial peptide	Homo sapiens	25-30
29366480-5	2018	Here, our results first found that Septin4 is involved in oxidative stress induced endothelial cell ROS production and apoptosis through knock-down and over-expression Septin4 approaches.	ros	100-103	septin 4	Homo sapiens	35-42
29331753-10	2018	The results show that the complex induces apoptosis through ROS-mediated mitochondria dysfunction and inhibition of AKT/mTOR pathways.	ros	60-63	AKT serine/threonine kinase 1	Homo sapiens	116-119
29331753-10	2018	The results show that the complex induces apoptosis through ROS-mediated mitochondria dysfunction and inhibition of AKT/mTOR pathways.	ros	60-63	mechanistic target of rapamycin kinase	Homo sapiens	120-124
29024600-0	2018	Liver X receptor alpha is targeted by microRNA-1 to inhibit cardiomyocyte apoptosis through a ROS-mediated mitochondrial pathway.	ros	94-97	nuclear receptor subfamily 1, group H, member 3	Rattus norvegicus	0-22
29415883-4	2018	Notably, DNA-PK activity is suppressed after irradiation when ROS induce the dissociation of DNA-PKcs with Ku70/80, resulting in delayed DNA repair and radiosensitivity; subsequently, after ROS clearance, the accumulated DNA damage and robust activation of DNA-PK induce genomic instability, facilitated by Rad50-mediated cell-cycle arrest, leading to enhanced malignancy, CSC overgrowth, and radioresistance.	ros	62-65	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	9-15
29415883-4	2018	Notably, DNA-PK activity is suppressed after irradiation when ROS induce the dissociation of DNA-PKcs with Ku70/80, resulting in delayed DNA repair and radiosensitivity; subsequently, after ROS clearance, the accumulated DNA damage and robust activation of DNA-PK induce genomic instability, facilitated by Rad50-mediated cell-cycle arrest, leading to enhanced malignancy, CSC overgrowth, and radioresistance.	ros	62-65	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	93-101
29415883-4	2018	Notably, DNA-PK activity is suppressed after irradiation when ROS induce the dissociation of DNA-PKcs with Ku70/80, resulting in delayed DNA repair and radiosensitivity; subsequently, after ROS clearance, the accumulated DNA damage and robust activation of DNA-PK induce genomic instability, facilitated by Rad50-mediated cell-cycle arrest, leading to enhanced malignancy, CSC overgrowth, and radioresistance.	ros	62-65	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	93-99
29415883-4	2018	Notably, DNA-PK activity is suppressed after irradiation when ROS induce the dissociation of DNA-PKcs with Ku70/80, resulting in delayed DNA repair and radiosensitivity; subsequently, after ROS clearance, the accumulated DNA damage and robust activation of DNA-PK induce genomic instability, facilitated by Rad50-mediated cell-cycle arrest, leading to enhanced malignancy, CSC overgrowth, and radioresistance.	ros	190-193	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	9-15
29128845-7	2018	CTPP-CSOSA/Cela highly enhanced ROS levels, which further induced mitochondria membrane potential decreasing and more Cytochrome C releasing into cytoplasm, then promoted tumor cells apoptosis notably.	ros	32-35	cytochrome c, somatic	Homo sapiens	118-130
29195919-8	2018	Interestingly, forced S-glutathionylation of p47phox converted the fMLP induced ROS generation into sustained release of ROS.	ros	80-83	formyl peptide receptor 1	Homo sapiens	67-71
29195919-8	2018	Interestingly, forced S-glutathionylation of p47phox converted the fMLP induced ROS generation into sustained release of ROS.	ros	121-124	formyl peptide receptor 1	Homo sapiens	67-71
29024245-2	2018	We examined the link between the cardiac phenotypes associated with hace1 loss of function to the expression of the Rho small family GTPase, rac1, which is a known target of HACE1 and promotes ROS production via its interaction with NADPH oxidase holoenzymes.	ros	193-196	Rac family small GTPase 1a	Danio rerio	141-145
29366441-7	2018	Furthermore, hypoxia-induced inflammation by HMGB1 translocation into the cytoplasm results in the release of IL-8 through a ROS-dependent mechanism in upper airway epithelium.	ros	125-128	C-X-C motif chemokine ligand 8	Homo sapiens	110-114
29330265-1	2018	PIN4 is a FGFR3-TACC3 substrate required for ROS-mediated induction of PGCIalpha and tumor growth.	ros	45-48	transforming acidic coiled-coil containing protein 3	Homo sapiens	16-21
29185215-0	2018	Nickle(II) ions exacerbate bleomycin-induced pulmonary inflammation and fibrosis by activating the ROS/Akt signaling pathway.	ros	99-102	thymoma viral proto-oncogene 1	Mus musculus	103-106
29159829-0	2018	Calcium hydroxide regulates transcription of the bone sialoprotein gene via a calcium-sensing receptor in osteoblast-like ROS 17/2.8 cells.	ros	122-125	integrin-binding sialoprotein	Rattus norvegicus	49-66
29159829-2	2018	In this study, we investigated the regulation of Bsp transcription by calcium hydroxide [Ca(OH)2 ] in rat osteosarcoma-derived osteoblast-like ROS 17/2.8 cells and stromal bone marrow cells.	ros	143-146	integrin-binding sialoprotein	Rattus norvegicus	49-52
29063476-0	2018	Fungal beta-Glucan Activates the NLRP3 Inflammasome in Human Bronchial Epithelial Cells Through ROS Production.	ros	96-99	NLR family pyrin domain containing 3	Homo sapiens	33-38
29098483-0	2018	Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling.	ros	114-117	NLR family pyrin domain containing 3	Homo sapiens	118-123
29098483-9	2018	Taken together, our results reveal that irisin alleviates AGEs-induced inflammation and endothelial dysfunction via inhibiting ROS-NLRP3 inflammasome signaling, suggest a likely mechanism for irisin-induced therapeutic effect in vascular complications of diabetes.	ros	127-130	NLR family pyrin domain containing 3	Homo sapiens	131-136
29063476-6	2018	Further studies demonstrated that the activation of NLRP3 inflammasome could be attenuated by NAC, an inhibitor of ROS.	ros	115-118	NLR family pyrin domain containing 3	Homo sapiens	52-57
29063476-7	2018	Thus, it indicated curdlan activate NLRP3 inflammasome through a pathway requiring ROS production in HBECs.	ros	83-86	NLR family pyrin domain containing 3	Homo sapiens	36-41
29251335-7	2018	It was observed that marmesin treatment triggered upregulation of Bax and downregulation of Bcl-2 causing significant increase in the Bax/Bcl-2 ratio, marmesin could also induce ROS mediated alterations in mitochondrial membrane potential.	ros	178-181	BCL2 associated X, apoptosis regulator	Homo sapiens	134-137
28600879-5	2018	IFN-gamma priming provoked ROS elevation, cell growth slowdown, attenuation of both spontaneous and induced osteodifferentiation of tissue O2 -adapted ASCs.	ros	27-30	interferon gamma	Homo sapiens	0-9
28600879-10	2018	After N-acetyl cysteine treatment ROS level was partly abolished providing additional enhancement of IL-6 and suppression of IL-8 and VEGF production.	ros	34-37	interleukin 6	Homo sapiens	101-105
28600879-10	2018	After N-acetyl cysteine treatment ROS level was partly abolished providing additional enhancement of IL-6 and suppression of IL-8 and VEGF production.	ros	34-37	C-X-C motif chemokine ligand 8	Homo sapiens	125-129
28600879-10	2018	After N-acetyl cysteine treatment ROS level was partly abolished providing additional enhancement of IL-6 and suppression of IL-8 and VEGF production.	ros	34-37	vascular endothelial growth factor A	Homo sapiens	134-138
28689792-13	2018	CONCLUSIONS: These studies support a potentially critical but previously unidentified function of the KYN/AhR axis in regulating IgE-mediated mast cell activation through ROS and ox-CaMKII in CRSwNP.	ros	171-174	aryl-hydrocarbon receptor	Mus musculus	106-109
29251335-7	2018	It was observed that marmesin treatment triggered upregulation of Bax and downregulation of Bcl-2 causing significant increase in the Bax/Bcl-2 ratio, marmesin could also induce ROS mediated alterations in mitochondrial membrane potential.	ros	178-181	BCL2 apoptosis regulator	Homo sapiens	138-143
29535798-6	2018	Since ROS cause DNA lesions, the activation of DNA damage signaling pathways may influence catalase expression.	ros	6-9	catalase	Homo sapiens	91-99
29552311-9	2018	We therefore demonstrated that miR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1/ROS/JNK pathway.	ros	111-114	mitogen-activated protein kinase 8	Homo sapiens	115-118
29253600-0	2018	Cadmium induced ROS alters M1 and M3 receptors, leading to SN56 cholinergic neuronal loss, through AChE variants disruption.	ros	16-19	acetylcholinesterase (Cartwright blood group)	Homo sapiens	99-103
29386120-0	2018	PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis.	ros	53-56	prohibitin 3	Arabidopsis thaliana	0-4
29386120-0	2018	PHB3 Maintains Root Stem Cell Niche Identity through ROS-Responsive AP2/ERF Transcription Factors in Arabidopsis.	ros	53-56	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	68-71
29275210-0	2018	Differences between seedlings and flowers in anti-ROS based heat responses of Arabidopsis plants deficient in cyclic nucleotide gated channel 2.	ros	50-53	Cyclic nucleotide-regulated ion channel family protein	Arabidopsis thaliana	110-143
28986287-11	2018	Thus, non-copper targeted ROS independent DNA damage is the central mechanism of coumestrol in ER-negative MDA-MB-231 cells.	ros	26-29	estrogen receptor 1	Homo sapiens	95-97
29107113-4	2018	By regulating the process of autophagy, miR-346 reduced the ROS level in the cells, thus protecting them from death following ER stress.	ros	60-63	microRNA 346	Homo sapiens	40-47
29554905-12	2018	TC-HW-induced ROS increased NF-kappaB and ATF3 activation, and inhibition of NF-kappaB and ATF3 activation attenuated TC-HW-mediated apoptosis.	ros	14-17	nuclear factor kappa B subunit 1	Homo sapiens	28-37
29554905-13	2018	CONCLUSIONS: Our results suggest that TC-HW may suppress cell proliferation through the downregulation of cyclin D1 via proteasomal degradation and transcriptional inhibition, and may induce apoptosis through ROS-dependent NF-kappaB and ATF3 activation.	ros	209-212	nuclear factor kappa B subunit 1	Homo sapiens	223-232
29346757-5	2018	This delay requires the p53 transcriptional target CDKN1A (encoding p21) and is associated with both slower depletion of intracellular glutathione and a reduced accumulation of toxic lipid-reactive oxygen species (ROS).	ros	214-217	tumor protein p53	Homo sapiens	24-27
29416349-0	2018	ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells.	ros	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	14-17
29416349-0	2018	ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells.	ros	0-3	BCL2 apoptosis regulator	Homo sapiens	18-22
29416349-0	2018	ROS-dependent Bax/Bcl2 and caspase 3 pathway-mediated apoptosis induced by zineb in human keratinocyte cells.	ros	0-3	caspase 3	Homo sapiens	27-36
29346757-5	2018	This delay requires the p53 transcriptional target CDKN1A (encoding p21) and is associated with both slower depletion of intracellular glutathione and a reduced accumulation of toxic lipid-reactive oxygen species (ROS).	ros	214-217	cyclin dependent kinase inhibitor 1A	Homo sapiens	51-57
29346757-5	2018	This delay requires the p53 transcriptional target CDKN1A (encoding p21) and is associated with both slower depletion of intracellular glutathione and a reduced accumulation of toxic lipid-reactive oxygen species (ROS).	ros	214-217	cyclin dependent kinase inhibitor 1A	Homo sapiens	68-71
29866021-2	2018	Reduced antioxidant defence system in transformed cells favors higher ROS production, which plays a significant role in carcinogenesis and acts as an important regulator of NF-kappaB.	ros	70-73	nuclear factor kappa B subunit 1	Homo sapiens	173-182
29141899-3	2018	In ventricular cardiac myocytes (VCM), Gbeta5 deficiency provided substantial protection against the cytotoxic actions of chemotherapeutics, including reductions in oxidative stress and simultaneous attenuation of ROS-dependent activation of the ATM and CaMKII proapoptotic signaling cascades.	ros	214-217	G protein subunit beta 5	Homo sapiens	39-45
29546056-11	2018	The present study showed that elevated ROS levels served as an inhibition on Bcl-2 activity that is at least in part responsible for apoptosis.	ros	39-42	BCL2 apoptosis regulator	Homo sapiens	77-82
30178377-9	2018	Cytokine stimulation was found to differentially affect gene expression of major ROS synthesizing enzymes: eNOS was decreased whereas COX-2 and NOX-4 were increased.	ros	81-84	nitric oxide synthase 3	Homo sapiens	107-111
30178377-9	2018	Cytokine stimulation was found to differentially affect gene expression of major ROS synthesizing enzymes: eNOS was decreased whereas COX-2 and NOX-4 were increased.	ros	81-84	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	134-139
29128359-6	2018	Silencing UCH-L1 significantly suppressed VEGF-induced ROS levels as well as activation of VEGFR, both of which are required for angiogenesis.	ros	55-58	vascular endothelial growth factor A	Homo sapiens	42-46
30109811-2	2018	Based on our finding that the p66 isoform of SHC1 (p66SHC) pro-apoptotic ROS-elevating SHC family adaptor inhibits MTOR signaling in these cells, here we investigated the role of p66SHC in B-cell autophagy.	ros	73-76	mechanistic target of rapamycin kinase	Homo sapiens	115-119
28918503-8	2018	The activation of p-GSK3beta expression, cyclophilin D inhibition, and p53 activation through ROS are involved in CoQ0-induced HL-60 apoptotic cell death.	ros	94-97	tumor protein p53	Homo sapiens	71-74
28918503-9	2018	Notably, ROS-independent p38 activation is involved in CoQ0-mediated apoptosis in HL-60 cells.	ros	9-12	mitogen-activated protein kinase 14	Homo sapiens	25-28
29909722-8	2018	Proteasome activity and ATP levels were reduced and the ROS levels was increased in Tom40 RNAi tissues.	ros	56-59	translocase of outer mitochondrial membrane 40	Homo sapiens	84-89
29909722-9	2018	The simultaneous inhibition of proteasome activity, reduction in ATP production, and increase in ROS, but none of these conditions alone, can mimic the imbalanced proteostasis phenotypes observed in Tom40 RNAi cells.	ros	97-100	translocase of outer mitochondrial membrane 40	Homo sapiens	199-204
30355941-12	2018	In addition to these two processes, mmu_circRNA_34132 may be a potential regulator of Nrf2-mediated protection for diabetes mellitus and Nrf2-mediated defence against ROS in hearts.	ros	167-170	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
30317243-0	2018	High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells.	ros	58-61	vascular endothelial growth factor C	Homo sapiens	21-27
30317243-0	2018	High Glucose Induces VEGF-C Expression via the LPA1/3-Akt-ROS-LEDGF Signaling Axis in Human Prostate Cancer PC-3 Cells.	ros	58-61	AKT serine/threonine kinase 1	Homo sapiens	54-57
29224514-7	2018	Our results suggested that the combination of the SRO1 and GPX3 may be contributed to plant response to mercury stress by regulating ROS intracellular oxidative homeostasis.	ros	133-136	similar to RCD one 1	Arabidopsis thaliana	50-54
30032136-14	2018	The metformin/FTY720 regimen markedly induced ROS generation; moreover, apoptosis, ER stress and inhibition of PI3K/AKT/ mTOR were attenuated by the ROS scavenger NAC.	ros	149-152	AKT serine/threonine kinase 1	Homo sapiens	116-119
30032136-14	2018	The metformin/FTY720 regimen markedly induced ROS generation; moreover, apoptosis, ER stress and inhibition of PI3K/AKT/ mTOR were attenuated by the ROS scavenger NAC.	ros	149-152	mechanistic target of rapamycin kinase	Homo sapiens	121-125
30317243-10	2018	Moreover, high glucose-induced VEGF-C expression was mediated through the LPA1/3, PLC, Akt, ROS and LEDGF-dependent pathways.	ros	92-95	vascular endothelial growth factor C	Homo sapiens	31-37
30355941-12	2018	In addition to these two processes, mmu_circRNA_34132 may be a potential regulator of Nrf2-mediated protection for diabetes mellitus and Nrf2-mediated defence against ROS in hearts.	ros	167-170	nuclear factor, erythroid derived 2, like 2	Mus musculus	137-141
29672298-13	2018	ROS then activates Ca2+-efflux mode of NCX and results in intracellular Na+ accumulation.	ros	0-3	solute carrier family 8 member A1	Rattus norvegicus	39-42
28812210-14	2018	In conclusion, IL-34-stimulated THP-1 can produce higher levels of ROS, which promoted IL-6 secretion and up-regulated Th17 cells.	ros	67-70	interleukin 34	Homo sapiens	15-20
29768267-0	2018	Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3sigma.	ros	63-66	AKT serine/threonine kinase 1	Homo sapiens	59-62
29768267-10	2018	High glucose, insulin and palmitic acid, alone or in combinations, induced ROS production and centrosome amplification.	ros	75-78	insulin	Homo sapiens	14-21
29768267-12	2018	Results from further analyses showed that AKT-ROS-dependent upregulations of expression, binding and centrosome translocation of ROCK1 and 14-3-3sigma was the molecular pathway underlying the centrosome amplification in vitro triggered by high glucose, insulin and palmitic acid.	ros	46-49	AKT serine/threonine kinase 1	Homo sapiens	42-45
29768267-12	2018	Results from further analyses showed that AKT-ROS-dependent upregulations of expression, binding and centrosome translocation of ROCK1 and 14-3-3sigma was the molecular pathway underlying the centrosome amplification in vitro triggered by high glucose, insulin and palmitic acid.	ros	46-49	insulin	Homo sapiens	253-260
29768267-14	2018	CONCLUSION: Our results show that type 2 diabetes promotes cell centrosome amplification, and suggest that the diabetic pathophysiological factors-activated AKT-ROS-dependent signalling of ROCK1 and 14-3-3sigma is the underlying molecular mechanism.	ros	161-164	AKT serine/threonine kinase 1	Homo sapiens	157-160
29145138-4	2018	Overall results suggest that 4-OPA, IPOH have cytotoxic effects on human lung cells that might be mediated by ROS: the highest concentration applied of IPOH [500 muM] enhanced ROS generation by 100-fold +- 7.7 (A549) and 230-fold +- 19.9 (16HBE14o-) compared to the baseline.	ros	176-179	latexin	Homo sapiens	162-165
29145138-5	2018	4-OPA [500 muM] increased ROS levels by 1.4-fold +- 0.3 (A549) and by 127-fold +- 10.5 (16HBE14o-), while treatment with 4-AMCH [500 muM] led to 0.9-fold +- 0.2 (A549) and 49-fold +- 12.8 (16HBE14o-) increase.	ros	26-29	latexin	Homo sapiens	11-14
29145138-4	2018	Overall results suggest that 4-OPA, IPOH have cytotoxic effects on human lung cells that might be mediated by ROS: the highest concentration applied of IPOH [500 muM] enhanced ROS generation by 100-fold +- 7.7 (A549) and 230-fold +- 19.9 (16HBE14o-) compared to the baseline.	ros	110-113	latexin	Homo sapiens	162-165
28812210-14	2018	In conclusion, IL-34-stimulated THP-1 can produce higher levels of ROS, which promoted IL-6 secretion and up-regulated Th17 cells.	ros	67-70	GLI family zinc finger 2	Homo sapiens	32-37
28812210-14	2018	In conclusion, IL-34-stimulated THP-1 can produce higher levels of ROS, which promoted IL-6 secretion and up-regulated Th17 cells.	ros	67-70	interleukin 6	Homo sapiens	87-91
28295305-10	2018	Taken together, we found that DOX induced mitochondrial ROS release to activate ERK-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo.	ros	56-59	mitogen-activated protein kinase 1	Homo sapiens	80-83
28969555-7	2018	However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective gene expression.	ros	24-27	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
28969555-7	2018	However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective gene expression.	ros	24-27	kelch like ECH associated protein 1	Homo sapiens	75-80
28969555-7	2018	However, high amount of ROS activates tyrosine kinases to dissociate Nrf2: Keap1 complex, nuclear import of Nrf2 and coordinated activation of cytoprotective gene expression.	ros	24-27	NFE2 like bZIP transcription factor 2	Homo sapiens	108-112
28969555-9	2018	Owning to the interplay of ROS and Nrf2 signaling pathways with carcinogenesis, Nrf2 modulation seems to be important in the personalization of cancer therapy.	ros	27-30	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
29468988-7	2018	COX-2 activity is associated with ROS production and inflammatory signs in normal tissues.	ros	34-37	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
29274627-5	2018	After inhibition of ABCG2 by its specific inhibitor, the drug sensitivity of As2O3 to A549 cells was significantly enhanced, manifested by decreased cell viability and colony formation as well as the increased ROS production and cell apoptosis.	ros	210-213	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	20-25
30103329-3	2018	In this work, we have studied the effects of these peptides on astrocytes in primary culture and found that the three Abeta peptides were internalized by astrocytes and significantly decreased astrocyte viability, while increasing ROS production.	ros	231-234	amyloid beta precursor protein	Homo sapiens	118-123
28295305-0	2018	Mitochondrial ROS-induced ERK1/2 activation and HSF2-mediated AT1 R upregulation are required for doxorubicin-induced cardiotoxicity.	ros	14-17	mitogen-activated protein kinase 3	Homo sapiens	26-32
28295305-5	2018	We found that MAPK signaling pathways, especially ERK1/2, participated in modulating AT1 R gene expression through DOX-induced mitochondrial ROS release.	ros	141-144	mitogen-activated protein kinase 3	Homo sapiens	14-18
28295305-5	2018	We found that MAPK signaling pathways, especially ERK1/2, participated in modulating AT1 R gene expression through DOX-induced mitochondrial ROS release.	ros	141-144	mitogen-activated protein kinase 3	Homo sapiens	50-56
28295305-10	2018	Taken together, we found that DOX induced mitochondrial ROS release to activate ERK-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo.	ros	56-59	heat shock transcription factor 2	Homo sapiens	93-97
29537483-3	2018	Among others, specific oxidative pathways involving both pro-oxidant and antioxidant enzymes seem to play a major role in the production of reactive oxidant species (ROS), such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, myeloperoxidase, superoxide dismutase, and glutathione peroxidase.	ros	166-169	myeloperoxidase	Homo sapiens	241-256
29098529-0	2018	18beta-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-alpha/ERK pathway.	ros	97-100	protein kinase C alpha	Homo sapiens	101-110
29098529-0	2018	18beta-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-alpha/ERK pathway.	ros	97-100	mitogen-activated protein kinase 1	Homo sapiens	111-114
29098529-6	2018	In conclusion, this study revealed that 18beta-GA inhibits migration and invasion via the ROS/PKC-alpha/ERK signaling pathway in gastric cancer cells.	ros	90-93	protein kinase C alpha	Homo sapiens	94-103
29098529-6	2018	In conclusion, this study revealed that 18beta-GA inhibits migration and invasion via the ROS/PKC-alpha/ERK signaling pathway in gastric cancer cells.	ros	90-93	mitogen-activated protein kinase 1	Homo sapiens	104-107
29332595-7	2018	All molecules demonstrated the potent ROS inhibition activity in the range of IC50 = 1.2 +- 0.1-48.8 +- 3.9 microM as compared to the standard ibuprofen (IC50 = 54.2 +- 9.2 muM).	ros	38-41	latexin	Homo sapiens	173-176
29527225-8	2017	Conclusion: Subclinical varicocele induces seminal and spermatozoal subclinical inflammatory response in the form of low-level leucospermia and increased mRNA expression of the fractalkine signaling pathway, leading to increased spermatozoal ROS production, oxidative stress, and DNA fragmentation.	ros	242-245	C-X3-C motif chemokine ligand 1	Homo sapiens	177-188
29154202-4	2018	NLRP1 activators in humans are still unknown, however we hypothesized that individuals with gain-of-function SNPs in NLRP1 could be more prone in activating inflammasome in the presence of asthma-related cell stressors (i.e. ER stress or ROS), and this activation contribute to exacerbate inflammatory response and asthma development.	ros	238-241	NLR family pyrin domain containing 1	Homo sapiens	117-122
28823537-13	2018	Moreover, ROS generation occurred upon treatment of SH-SY5Y cells with HPO-DAEE, and the antioxidants N-acetylcysteine and glutathione suppressed HPO-DAEE-induced activation of the Nrf2-ARE and eIF2alpha-ATF4 pathways.	ros	10-13	NFE2 like bZIP transcription factor 2	Homo sapiens	181-185
29425644-9	2018	Ligustilide significantly inhibited TNF-alpha-increased production of ROS and activated NF-kappaB signaling pathway.	ros	70-73	tumor necrosis factor	Homo sapiens	36-45
30115431-6	2018	ROS formation and lipid peroxidation were found in several investigations and may be caused by increased insulin, fatty acid and glucose levels or indirectly via inflammation.	ros	0-3	insulin	Homo sapiens	105-112
28902451-9	2018	Furthermore, overexpression of UGT76E11 also enhanced the scavenging capacity for ROS and increased expression levels of a number of stress-related genes.	ros	82-85	UDP-glucosyl transferase 76E11	Arabidopsis thaliana	31-39
29233104-12	2017	Additionally, LPS increases THP-1(A) cells" bactericidal activities including phagocytosis, ROS production, and destruction of M. tuberculosis.	ros	92-95	GLI family zinc finger 2	Homo sapiens	28-33
29383185-0	2017	GPER-independent inhibition of adrenocortical cancer growth by G-1 involves ROS/Egr-1/BAX pathway.	ros	76-79	BCL2 associated X, apoptosis regulator	Homo sapiens	86-89
29383185-9	2017	The identified ROS/MAPK/Egr-1/BAX pathway as a potential off-target effect of the G-1 could be useful in implementing the pharmacological approach for ACC therapy.	ros	15-18	BCL2 associated X, apoptosis regulator	Homo sapiens	30-33
29256392-5	2017	Knockout of HIG2 enhanced LD breakdown and fatty acid (FA) oxidation, leading to increased ROS production and apoptosis in hypoxic cancer cells as well as impaired growth of tumor xenografts.	ros	91-94	hypoxia inducible lipid droplet associated	Homo sapiens	12-16
29256392-7	2017	Thus, by inhibiting ATGL, HIG2 acts downstream of HIF-1 to sequester FAs in LDs away from the mitochondrial pathways for oxidation and ROS generation, thereby sustaining cancer cell survival in hypoxia.	ros	135-138	hypoxia inducible lipid droplet associated	Homo sapiens	26-30
29256392-7	2017	Thus, by inhibiting ATGL, HIG2 acts downstream of HIF-1 to sequester FAs in LDs away from the mitochondrial pathways for oxidation and ROS generation, thereby sustaining cancer cell survival in hypoxia.	ros	135-138	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-55
28988741-0	2017	Smad7 alleviates glomerular mesangial cell proliferation via the ROS-NF-kappaB pathway.	ros	65-68	SMAD family member 7	Rattus norvegicus	0-5
28988741-1	2017	OBJECTIVE: The aim of this study was to demonstrate that altered gene expression of Smad7regulated NF-kappaB expression and ROS production on Ang II (Angiotensin II)-induced rat glomerular mesangial cell (GMC) proliferation.	ros	124-127	SMAD family member 7	Rattus norvegicus	84-89
28988741-1	2017	OBJECTIVE: The aim of this study was to demonstrate that altered gene expression of Smad7regulated NF-kappaB expression and ROS production on Ang II (Angiotensin II)-induced rat glomerular mesangial cell (GMC) proliferation.	ros	124-127	angiotensinogen	Rattus norvegicus	142-148
28988741-1	2017	OBJECTIVE: The aim of this study was to demonstrate that altered gene expression of Smad7regulated NF-kappaB expression and ROS production on Ang II (Angiotensin II)-induced rat glomerular mesangial cell (GMC) proliferation.	ros	124-127	angiotensinogen	Rattus norvegicus	150-164
28988741-7	2017	RESULTS: Over-expression of Smad7 dampened the ability of Ang II to promote ROS synthesis and inhibited the ability of Ang II to decrease functional expression of IkappaBalpha.	ros	76-79	SMAD family member 7	Rattus norvegicus	28-33
28988741-12	2017	CONCLUSIONS: Smad7 influenced NF-kappaB expression by regulating ROS generation, and induced GMC apoptosis to counter the Ang II-promoted proliferation.	ros	65-68	SMAD family member 7	Rattus norvegicus	13-18
29435131-5	2018	The expression of HIF-1alpha and YAP1 was concomitantly decreased by PD-L1 silencing or by ROS scavenger treatment (N-acetylcysteine, NAC); however, a ROS inducer treatment (pyocyanin) completely reversed the decreased expression of both genes in EGFR-mutated and -wild-type (WT) NSCLC cells.	ros	91-94	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
29371968-7	2017	Notably, inhibition of ROS production prevented ERK suppression, and blockage of ERK in combination with AMRI-59 and IR led to enhanced caspase-3 activation and apoptosis.	ros	23-26	mitogen-activated protein kinase 1	Mus musculus	48-51
29371968-9	2017	Taken together, the results indicate that AMRI-59 functions as a PRX I-targeted radiosensitizer by inducing apoptosis through activation of the ROS/gammaH2AX/caspase pathway and suppression of ERK.	ros	144-147	H2A.X variant histone	Mus musculus	148-157
29435131-5	2018	The expression of HIF-1alpha and YAP1 was concomitantly decreased by PD-L1 silencing or by ROS scavenger treatment (N-acetylcysteine, NAC); however, a ROS inducer treatment (pyocyanin) completely reversed the decreased expression of both genes in EGFR-mutated and -wild-type (WT) NSCLC cells.	ros	151-154	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
29435131-5	2018	The expression of HIF-1alpha and YAP1 was concomitantly decreased by PD-L1 silencing or by ROS scavenger treatment (N-acetylcysteine, NAC); however, a ROS inducer treatment (pyocyanin) completely reversed the decreased expression of both genes in EGFR-mutated and -wild-type (WT) NSCLC cells.	ros	151-154	epidermal growth factor receptor	Homo sapiens	247-251
29435131-7	2018	Mechanistic studies indicated that upregulation of YAP1 by PD-L1 might be responsible for EGFR mutation-independent TKI resistance via the ROS/HIF-1alpha axis.	ros	139-142	epidermal growth factor receptor	Homo sapiens	90-94
28857396-11	2017	The mechanism involved showed a higher ROS production, which probably activates AP-1 transcription factor and, as a result, ECE-1 expression, increasing ET-1 synthesis, which in consequence induces endothelial senescence.	ros	39-42	endothelin 1	Homo sapiens	153-157
29340103-7	2017	Exposure of these cells to anti-neoplastic drugs for short periods of time (24-48 h) increased CAV1 expression through ROS production and MEK/ERK activation.	ros	119-122	caveolin 1	Homo sapiens	95-99
29354292-10	2017	Similarly to the effects induced by PN, downregulation of Nrf2 was accompanied by reductions in the levels of catalase, MnSOD, HSP70 and Bcl-2, prevention of chemoresistance and increased ability to generate ROS under stimulation.	ros	208-211	NFE2 like bZIP transcription factor 2	Homo sapiens	58-62
29354292-7	2017	Moreover, as a consequence of overexpression of Nrf2 and correlated proteins, drug-treated cells exhibited a much lower ability than parental cells to generate ROS in response to a suitable stimulation.	ros	160-163	NFE2 like bZIP transcription factor 2	Homo sapiens	48-52
29063293-0	2017	Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.	ros	109-112	mechanistic target of rapamycin kinase	Homo sapiens	4-8
29063293-0	2017	Two mTOR inhibitors, rapamycin and Torin 1, differentially regulate iron-induced generation of mitochondrial ROS.	ros	109-112	peroxiredoxin 2	Homo sapiens	35-40
29063293-6	2017	At a higher concentration of iron, Torin 1, instead of rapamycin, could further aggravate iron-induced cytotoxicity, and mitochondrial ROS levels were significantly higher in Torin 1-treated cells.	ros	135-138	peroxiredoxin 2	Homo sapiens	175-180
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	23-26	S100 calcium binding protein B	Homo sapiens	82-87
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	23-26	nuclear factor kappa B subunit 1	Homo sapiens	99-108
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	23-26	nuclear factor kappa B subunit 1	Homo sapiens	133-142
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	23-26	S100 calcium binding protein B	Homo sapiens	167-172
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	129-132	S100 calcium binding protein B	Homo sapiens	82-87
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	129-132	nuclear factor kappa B subunit 1	Homo sapiens	99-108
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	129-132	nuclear factor kappa B subunit 1	Homo sapiens	133-142
28885620-6	2017	Here we show that: (1) ROS overproduction in myoblasts results in upregulation of S100B levels via NF-kappaB activation; and (2) ROS/NF-kappaB-induced accumulation of S100B causes myoblast transition into brown adipocytes.	ros	129-132	S100 calcium binding protein B	Homo sapiens	167-172
28836394-0	2017	Reduced Nrf2 activation in PI3K phosphorylation-impaired vitiliginous keratinocytes increases susceptibility to ROS-generating chemical-induced apoptosis.	ros	112-115	NFE2 like bZIP transcription factor 2	Homo sapiens	8-12
28836394-5	2017	Results showed that 4-TBP or HQ treatment increased apoptosis and the expression levels of TNF-alpha, IL-1alpha, and ROS in PI3K-knockdown keratinocytes which reduced Nrf2 nuclear translocation compared to control keratinocytes.	ros	117-120	NFE2 like bZIP transcription factor 2	Homo sapiens	167-171
29203387-6	2017	In conclusion, the AIF activated Nrf2 signaling pathway was observed to suppress Dex-induced ROS production in osteoblastic and osteocytic cells, which may explain its anti-osteoporotic effects against dexamethasone-induced osteoporosis.	ros	93-96	NFE2 like bZIP transcription factor 2	Rattus norvegicus	33-37
29272019-4	2017	Nitrate reduction method was used to measure the content of nitric oxide (NO) and radioimmunoassay was used to measure endothelin-1; Western blot assay was used to detect the expression of B-cell lymphoma-2 (Bcl-2), and flow cytometry was used to detect the intracellular level of reactive oxygen (ROS) and apoptosis of HUVECs.	ros	298-301	BCL2 apoptosis regulator	Homo sapiens	208-213
29272019-5	2017	RESULTS: Our study found that ARRB2 could significantly reduce the generation and release of ROS, endothelin-1 (ET-1), lactic dehydrogenase (LDH) of HUVECs induced by Ang II and promote the generation of NO, superoxide dismutase (SOD) and scavenging in a dose-dependent manner.	ros	93-96	arrestin beta 2	Homo sapiens	30-35
29272019-5	2017	RESULTS: Our study found that ARRB2 could significantly reduce the generation and release of ROS, endothelin-1 (ET-1), lactic dehydrogenase (LDH) of HUVECs induced by Ang II and promote the generation of NO, superoxide dismutase (SOD) and scavenging in a dose-dependent manner.	ros	93-96	angiotensinogen	Homo sapiens	167-173
29272019-6	2017	On the contrary, when expression of ARRB2 was disturbed by siRNA, increased generation and release of ROS, ET-1, and LDH were observed with reduced generation of NO, SOD and scavenging.	ros	102-105	arrestin beta 2	Homo sapiens	36-41
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	sirtuin 1	Rattus norvegicus	99-104
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	NFE2 like bZIP transcription factor 2	Rattus norvegicus	150-154
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	NFE2 like bZIP transcription factor 2	Rattus norvegicus	150-154
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	NFE2 like bZIP transcription factor 2	Rattus norvegicus	150-154
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	transforming growth factor, beta 1	Rattus norvegicus	438-447
28986276-10	2017	INSL5 could attenuate generation of mitochondrial ROS at the 1, 10, 30, and 100nmol/L doses.	ros	50-53	insulin like 5	Homo sapiens	0-5
29111231-0	2017	ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	4-7
29111231-0	2017	ROS-AKT-mTOR axis mediates autophagy of human umbilical vein endothelial cells induced by cooking oil fumes-derived fine particulate matters in vitro.	ros	0-3	mechanistic target of rapamycin kinase	Homo sapiens	8-12
29111231-11	2017	These findings demonstrate ROS-AKT-mTOR axis plays a critical role in HUVECs autophagy induced by COFs-derived PM2.5.	ros	27-30	AKT serine/threonine kinase 1	Homo sapiens	31-34
29111231-11	2017	These findings demonstrate ROS-AKT-mTOR axis plays a critical role in HUVECs autophagy induced by COFs-derived PM2.5.	ros	27-30	mechanistic target of rapamycin kinase	Homo sapiens	35-39
28417552-0	2017	Enhanced phototoxicity of photodynamic treatment by Cx26-composed GJIC via ROS-, calcium- and lipid peroxide-mediated pathways.	ros	75-78	gap junction protein beta 2	Homo sapiens	52-56
28430389-8	2017	The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1.	ros	4-7	epidermal growth factor receptor	Homo sapiens	112-116
28430389-8	2017	The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1.	ros	4-7	AKT serine/threonine kinase 1	Homo sapiens	164-167
28430389-8	2017	The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1.	ros	4-7	mitogen-activated protein kinase 3	Homo sapiens	176-182
29074644-9	2017	These findings reveal renal ERK1/2 as an important initial regulator of KIM-1 expression in IR and septic AKI and at a physiologic level.Visual Abstract.Proposed mechanism of IR, LPS, and ROS-induced renal damage that initiates ERK1/2 and STAT3 phosphorylation.	ros	188-191	hepatitis A virus cellular receptor 1	Mus musculus	72-77
29074644-9	2017	These findings reveal renal ERK1/2 as an important initial regulator of KIM-1 expression in IR and septic AKI and at a physiologic level.Visual Abstract.Proposed mechanism of IR, LPS, and ROS-induced renal damage that initiates ERK1/2 and STAT3 phosphorylation.	ros	188-191	signal transducer and activator of transcription 3	Mus musculus	239-244
28465088-8	2017	In addition, the results indicated that the content of glutathione (GSH) was significantly increased after activation of Nrf2, and the level of ROS decreased; however, this effect contradictory in the Nrf2 knockout mice.	ros	144-147	nuclear factor, erythroid derived 2, like 2	Mus musculus	201-205
28569420-0	2017	Rhodopsin T17M Mutant Inhibits Complement C3 Secretion in Retinal Pigment Epithelium via ROS Induced Downregulation of TWIST1.	ros	89-92	rhodopsin	Homo sapiens	0-9
28569420-0	2017	Rhodopsin T17M Mutant Inhibits Complement C3 Secretion in Retinal Pigment Epithelium via ROS Induced Downregulation of TWIST1.	ros	89-92	twist family bHLH transcription factor 1	Homo sapiens	119-125
28569420-9	2017	The overexpression of T17M rhodopsin significantly induced ROS and reduced C3 secretion and transcription in ARPE-19 cells, but ROS scavengers could partially rescue reduced C3 secretion and transcription.	ros	59-62	rhodopsin	Homo sapiens	27-36
28569420-10	2017	Mechanistically, we found that ROS suppressed transcription factor TWIST1 which is responsible for activated transcription of C3.	ros	31-34	twist family bHLH transcription factor 1	Homo sapiens	67-73
28569420-11	2017	In conclusion, our data provide the first evidence that T17M rhodopsin mutant disrupts C3 secretion via the induction of ROS and the suppression of TWIST1.	ros	121-124	rhodopsin	Homo sapiens	61-70
29031211-0	2017	Cyanidin-3-O-glucoside inhibits the UVB-induced ROS/COX-2 pathway in HaCaT cells.	ros	48-51	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	52-57
29125808-7	2017	Apoptosis and generation of reactive oxidative species (ROS) from THP-1 cells were detected by flow cytometry.	ros	56-59	GLI family zinc finger 2	Homo sapiens	66-71
29507662-8	2018	Simultaneous Teneligliptin and GLP-1 synergistically increased the antioxidant response and reduced ROS levels in HG- and HM-exposed HUVECs.	ros	100-103	glucagon	Homo sapiens	31-36
28986276-13	2017	This study, for the first time, clarified the expression and localization of RXFP4 on human sperm and revealed the role of INSL5 in sperm motility and mitochondrial ROS generation in a dose-dependent manner.	ros	165-168	insulin like 5	Homo sapiens	123-128
29299162-9	2017	CDDP-mediated intracellular ROS increment plays an important role in FOXO3-MUL1-AKT signal pathway.	ros	28-31	forkhead box O3	Homo sapiens	69-74
29299162-9	2017	CDDP-mediated intracellular ROS increment plays an important role in FOXO3-MUL1-AKT signal pathway.	ros	28-31	AKT serine/threonine kinase 1	Homo sapiens	80-83
28942022-10	2017	In conclusion, our results demonstrate that autophagy-mediated ROS reduction is responsible for X-11-5-27-induced NLRP3 flammasome inactivation.	ros	63-66	NLR family pyrin domain containing 3	Homo sapiens	114-119
29179721-7	2017	Mechanistically, apigenin activated p53 that induced catalase, a ROS scavenger enzyme, and inhibited STAT3, the most important pro-survival pathway in PEL, as assessed by p53 silencing.	ros	65-68	tumor protein p53	Homo sapiens	36-39
29312589-7	2017	Enhanced ROS generation rescued the p-STAT3 and CyclinD1 expression reduction in G6PD-knockdown cells, while ROS scavengers reversed the up-regulated p-STAT3 and CyclinD1 expression in G6PD-overexpressing cells.	ros	9-12	signal transducer and activator of transcription 3	Homo sapiens	38-43
29312589-7	2017	Enhanced ROS generation rescued the p-STAT3 and CyclinD1 expression reduction in G6PD-knockdown cells, while ROS scavengers reversed the up-regulated p-STAT3 and CyclinD1 expression in G6PD-overexpressing cells.	ros	109-112	signal transducer and activator of transcription 3	Homo sapiens	152-157
29182677-8	2017	The pub12 pub13 mutant exhibited enhanced chitin-induced immune responses such as ROS production, MAPK activation, and callose deposition.	ros	82-85	armadillo/beta-catenin repeat protein	Arabidopsis thaliana	4-9
29089467-9	2017	RESULTS: Expression of STIM1/Orai1/TRPC1 significantly increased in transcript and translation level after MIRI in vivo and H/R in vitro In H9C2 cardiomyocytes subjected to H/R, intracellular Ca2+ accumulation significantly increased compared with control group, along with enhanced mPTP opening and elevated ROS generation.	ros	309-312	stromal interaction molecule 1	Rattus norvegicus	23-28
29089467-10	2017	However, suppression of STIM1 by SiRNA significantly decreased apoptosis and intracellular Ca2+ accumulation induced by H/R in H9C2 cardiomyocytes, accompanied by attenuated mPTP opening and decreased ROS generation.	ros	201-204	stromal interaction molecule 1	Rattus norvegicus	24-29
29176033-4	2017	Using human umbilical vein endothelial cells (HUVECs) as a model, we show that TNFalpha induces permanent growth arrest and increases p21CIP1, p16INK4A, and SA-beta-gal, accompanied by persistent DNA damage and ROS production.	ros	211-214	tumor necrosis factor	Homo sapiens	79-87
29176033-7	2017	Furthermore, we show STAT1/3 activation is necessary for cytokine and ROS production during TNFalpha-induced senescence.	ros	70-73	tumor necrosis factor	Homo sapiens	92-100
29312589-6	2017	G6PD up-regulated ROS generation by facilitating NADPH-dependent NOX4 activation, which led to increased expression of p-STAT3 and CyclinD1.	ros	18-21	signal transducer and activator of transcription 3	Homo sapiens	121-126
29296173-10	2017	We have further shown that scavenging ROS with EcSOD significantly inhibited RMF-HGF-stimulated orthotopic tumor growth of MDA-MB231.	ros	38-41	superoxide dismutase 3	Homo sapiens	47-52
29276688-5	2018	Marked decrease of activity of antioxidant enzymes such as SOD (85.36%), CAT (67.47%), GPx (50.7%) had indicated that the ROS mediated toxicity and pretreatment of BHA and BHT restored the activity of these enzymes.	ros	122-125	catalase	Rattus norvegicus	73-76
28942112-4	2017	Further investigations on mechanism of action of this class of compound demonstrated that the representative compound 8k could trigger p53/Bax-independent colorectal cancer cell apoptosis via inducing ROS accumulation.	ros	201-204	tumor protein p53	Homo sapiens	135-138
28713020-12	2017	CONCLUSION: The results suggest that PLY inhibits osteoblast differentiation by downregulation of Sp1 accompanied by induction of autophagy through ROS-mediated regulation of the AMPK/mTOR pathway.	ros	148-151	mechanistic target of rapamycin kinase	Homo sapiens	184-188
29118672-0	2017	Correction to: The role of ppargamma and autophagy in ros production, lipid droplets biogenesis and its involvement with colorectal cancer cells modulation.	ros	54-57	peroxisome proliferator activated receptor gamma	Homo sapiens	27-36
28709950-8	2017	NSC 737392 and 734428, which both feature nitro functional groups at the meta position, had &gt;10-fold higher activity against ROS production by cells that overexpress dual oxidase 2 (DUOX2) than the other compounds examined (IC50 200-400nM).	ros	128-131	dual oxidase 2	Homo sapiens	169-183
28709950-8	2017	NSC 737392 and 734428, which both feature nitro functional groups at the meta position, had &gt;10-fold higher activity against ROS production by cells that overexpress dual oxidase 2 (DUOX2) than the other compounds examined (IC50 200-400nM).	ros	128-131	dual oxidase 2	Homo sapiens	185-190
28713020-10	2017	PLY induced autophagy through ROS-mediated regulation of AMPK and mTOR, which downregulated the expression of Sp1 and subsequent inhibition of differentiation.	ros	30-33	mechanistic target of rapamycin kinase	Homo sapiens	66-70
28823958-0	2017	AP1G1 is involved in cetuximab-mediated downregulation of ASCT2-EGFR complex and sensitization of human head and neck squamous cell carcinoma cells to ROS-induced apoptosis.	ros	151-154	adaptor related protein complex 1 subunit gamma 1	Homo sapiens	0-5
28926928-7	2017	Furthermore, we found that ROS-dependent HIF-1alpha and its downstream proteins also play an important role on Curcumin induced apoptosis.	ros	27-30	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
28843908-5	2017	Mechanically, AIF aggravated irradiation-induced ROS generation in ESCC cells, which occurred via suppressing the expression of nuclear transcription factor Nrf2 and Nrf2-driven antioxidant molecule NQO-1 and HO-1.	ros	49-52	NFE2 like bZIP transcription factor 2	Homo sapiens	157-161
28843908-5	2017	Mechanically, AIF aggravated irradiation-induced ROS generation in ESCC cells, which occurred via suppressing the expression of nuclear transcription factor Nrf2 and Nrf2-driven antioxidant molecule NQO-1 and HO-1.	ros	49-52	NFE2 like bZIP transcription factor 2	Homo sapiens	166-170
28444875-8	2017	Collectively, this study showed that MGO-induced apoptosis is dependent on c-FLIPL down-regulation via ROS-mediated down-regulation of p65 expression in endothelial cells.	ros	103-106	CASP8 and FADD like apoptosis regulator	Homo sapiens	75-82
28444875-5	2017	In addition, pre-treatment with the ROS scavenger NAC prevented the MGO-induced down-regulation of p65 and c-FLIPL , and the forced expression of c-FLIPL attenuated MGO-mediated apoptosis.	ros	36-39	CASP8 and FADD like apoptosis regulator	Homo sapiens	107-114
28716970-2	2017	Metabolically demanding high-intensity exercise can induce PLFFD accompanied by ROS-dependent fragmentation of the sarcoplasmic reticulum Ca2+ release channels, the ryanodine receptor 1s (RyR1s).	ros	80-83	ryanodine receptor 1	Homo sapiens	165-185
28961497-0	2017	Irisin protects against neuronal injury induced by oxygen-glucose deprivation in part depends on the inhibition of ROS-NLRP3 inflammatory signaling pathway.	ros	115-118	NLR family, pyrin domain containing 3	Rattus norvegicus	119-124
28961497-7	2017	Taken together, our results firstly revealed that irisin mitigated OGD-induced neuronal injury in part via inhibiting ROS-NLRP3 inflammatory signaling pathway, suggesting a likely mechanism for irisin-induced therapeutic effect in ischemic stroke.	ros	118-121	NLR family, pyrin domain containing 3	Rattus norvegicus	122-127
28366933-0	2017	A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.	ros	130-133	Abelson helper integration site 1	Homo sapiens	8-13
28366933-6	2017	Importantly, a new AHI-1-BCR-ABL-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS-mediated autophagy.	ros	175-178	Abelson helper integration site 1	Homo sapiens	19-24
28961497-5	2017	Our data showed that both irisin and its precursor protein fibronectin type III domain containing 5 (FNDC5) expression were significantly down-regulated (p&lt;0.05); but oxidative stress and ROS-NLRP3 inflammasome signaling were activated by OGD (p&lt;0.05); treatment with irisin or inhibition of NLRP3 reversed OGD-induced oxidative stress and inflammation (p&lt;0.05).	ros	191-194	NLR family, pyrin domain containing 3	Rattus norvegicus	195-200
29228623-10	2017	CREB promotes the detoxification of ROS by catalase, therefore protecting the mitochondrial activity under oxidative stress.	ros	36-39	cAMP responsive element binding protein 1	Mus musculus	0-4
28919254-6	2017	Finally, inhibiting mitochondrial ROS production with mitoTEMPO prevented the deleterious effect of PA on insulin signaling.	ros	34-37	insulin	Homo sapiens	106-113
29732415-2	2017	This ROS Protocol article describes an in vivo bioluminescence imaging assay for assessing NF-kappaB activation using the commercially available transgenic mice carrying NF-kappaB response element-luciferase reporter gene (NF-kappaB-RE-Luc).	ros	5-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
29732415-2	2017	This ROS Protocol article describes an in vivo bioluminescence imaging assay for assessing NF-kappaB activation using the commercially available transgenic mice carrying NF-kappaB response element-luciferase reporter gene (NF-kappaB-RE-Luc).	ros	5-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	170-179
29732415-2	2017	This ROS Protocol article describes an in vivo bioluminescence imaging assay for assessing NF-kappaB activation using the commercially available transgenic mice carrying NF-kappaB response element-luciferase reporter gene (NF-kappaB-RE-Luc).	ros	5-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-100
28867437-5	2017	Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription.	ros	37-40	mitogen-activated protein kinase 14	Homo sapiens	50-53
28867437-5	2017	Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription.	ros	37-40	mitogen-activated protein kinase 1	Homo sapiens	54-58
28665927-6	2017	In agreement with this, overexpression of p66shc or knockdown of Nrf2/MnSOD augmented nicotine-induced ROS production in renal proximal tubule cells.ConclusionChronic nicotine exposure incites higher oxidative stress in the adolescent than in adult kidney because of a pre-existent pro-oxidant milieu.	ros	103-106	nuclear factor, erythroid derived 2, like 2	Mus musculus	65-69
28665927-6	2017	In agreement with this, overexpression of p66shc or knockdown of Nrf2/MnSOD augmented nicotine-induced ROS production in renal proximal tubule cells.ConclusionChronic nicotine exposure incites higher oxidative stress in the adolescent than in adult kidney because of a pre-existent pro-oxidant milieu.	ros	103-106	superoxide dismutase 2, mitochondrial	Mus musculus	70-75
28335665-8	2017	Inhibition of ROS by N-acetyl-l-cysteine (NAC) attenuated the activation of Akt, ASK1, p38 MAPK, and down-regulation of ZO-1 and occludin.	ros	14-17	tight junction protein 1	Canis lupus familiaris	120-137
29163585-10	2017	We propose that CRK36, together with BIK1 and NADPH oxidases, may form a positive activation loop that enhances ROS burst and leads to the promotion of stomatal immunity.	ros	112-115	botrytis-induced kinase1	Arabidopsis thaliana	37-41
29057315-8	2017	Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia.	ros	131-134	interleukin 1 beta	Homo sapiens	211-219
29066782-5	2017	Similar dependency on quenching of ROS due to influential hydrogen bond interaction with glycine residue of Sod1 oxidative stress protein and increased apoptosis were observed in cells.	ros	35-38	superoxide dismutase 1, soluble	Danio rerio	108-112
29057315-8	2017	Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia.	ros	131-134	NLR family pyrin domain containing 3	Homo sapiens	285-290
29057315-8	2017	Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia.	ros	131-134	interleukin 1 beta	Homo sapiens	211-219
29057315-8	2017	Furthermore, the pesticides enhanced mitochondrial ROS generation in primary microglia, while amelioration of mitochondria-derived ROS by the mitochondria-targeted antioxidant mito-apocynin completely abolished IL-1beta release, indicating mitochondrial ROS drives potentiation of the NLRP3 inflammasome in microglia.	ros	131-134	NLR family pyrin domain containing 3	Homo sapiens	285-290
28946937-10	2017	Our data also suggest that secreted IL-6 regulates CLB2.0-induced MUC5AC and MUC1 expression via ROS-mediated downregulation of claudin-1 expression to maintain mucus homeostasis in the airway.	ros	97-100	interleukin 6	Homo sapiens	36-40
28784718-5	2017	TRMT1-deficient cells exhibit decreased proliferation rates, alterations in global protein synthesis, and perturbations in redox homeostasis, including increased endogenous ROS levels and hypersensitivity to oxidizing agents.	ros	173-176	tRNA methyltransferase 1	Homo sapiens	0-5
28812425-0	2017	Nasunin inhibits the lipopolysaccharide-induced pro-inflammatory mediator production in RAW264 mouse macrophages by suppressing ROS-mediated activation of PI3 K/Akt/NF-kappaB and p38 signaling pathways.	ros	128-131	thymoma viral proto-oncogene 1	Mus musculus	161-164
28812425-0	2017	Nasunin inhibits the lipopolysaccharide-induced pro-inflammatory mediator production in RAW264 mouse macrophages by suppressing ROS-mediated activation of PI3 K/Akt/NF-kappaB and p38 signaling pathways.	ros	128-131	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	165-174
28812425-6	2017	Moreover, nasunin inhibited the intracellular accumulation of ROS, leading to the suppression of NF-kappaB activation, Akt and p38 phosphorylation, and subsequent pro-inflammatory mediator production.	ros	62-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	97-106
28812425-6	2017	Moreover, nasunin inhibited the intracellular accumulation of ROS, leading to the suppression of NF-kappaB activation, Akt and p38 phosphorylation, and subsequent pro-inflammatory mediator production.	ros	62-65	thymoma viral proto-oncogene 1	Mus musculus	119-122
28885018-5	2017	At high doses, genotoxicity resulting from ROS hypergeneration was due to suppression of Complex I subunits in the electron transport chain and activation of PPARalpha in both genders.	ros	43-46	peroxisome proliferator activated receptor alpha	Mus musculus	158-167
28946937-5	2017	CLB2.0-induced IL-6 secretion was mediated by ROS.	ros	46-49	interleukin 6	Homo sapiens	15-19
28946937-6	2017	The ROS scavenger N-acetylcysteine inhibited CLB2.0-induced IL-6 secretion, thereby decreasing the CLB2.0-induced MUC5AC expression, whereas CLB2.0-induced MUC1 expression increased.	ros	4-7	interleukin 6	Homo sapiens	60-64
28946937-7	2017	CLB2.0 activated the ERK1/2 MAPK via a ROS-dependent pathway.	ros	39-42	mitogen-activated protein kinase 3	Homo sapiens	21-27
28786152-7	2017	In addition, the combined stimuli induced up-regulation of PGC-1alpha expression was partly mediated by ROS and P38 signaling pathway.	ros	104-107	PPARG coactivator 1 alpha	Homo sapiens	59-69
28946937-9	2017	These findings suggest that CLB2.0-induced ERK1/2 activation acts as a switch for regulating inflammatory conditions though a ROS-dependent pathway.	ros	126-129	mitogen-activated protein kinase 3	Homo sapiens	43-49
28655711-3	2017	We found that ROS induced a robust expression of FOXD3-AS1 in mouse lung tissue.	ros	14-17	arylsulfatase B	Mus musculus	55-58
28791350-5	2017	We found that PRL-3 improved colorectal cancer cell glucose assumption, lactate production and reduced intracellular ROS levels.	ros	117-120	protein tyrosine phosphatase 4A3	Homo sapiens	14-19
28444510-7	2017	We provide new evidence that Yak1, Rim15 and Mck1 kinases cooperate to activate H2O2-scanvenging activities, thus limiting the levels of ROS in cells entering quiescence.	ros	137-140	protein kinase RIM15	Saccharomyces cerevisiae S288C	35-40
28444510-7	2017	We provide new evidence that Yak1, Rim15 and Mck1 kinases cooperate to activate H2O2-scanvenging activities, thus limiting the levels of ROS in cells entering quiescence.	ros	137-140	serine/threonine/tyrosine protein kinase MCK1	Saccharomyces cerevisiae S288C	45-49
28674855-6	2017	We observed that 6 h pretreatment with CA (1.25, 2.5, 5 muM) decreased RANKL-induced osteoclast formation and abolished RANKL-induced ROS generation by activating Nrf2 and its transcriptional targets.	ros	134-137	nuclear factor, erythroid derived 2, like 2	Mus musculus	163-167
28328092-7	2017	Furthermore, we also provide a mechanistic insight and show that the enhanced apoptosis was a result of at least in part, a sustained activation of the p38 MAPK pathway in a ROS-dependent mechanism.	ros	174-177	mitogen-activated protein kinase 14	Homo sapiens	152-155
28302706-4	2017	Intravital microscopy of the mesentery showed that after 3 wk of hypoxia (barometric pressure ~380 Torr; partial pressure of inspired O2 ~68-70 Torr), rats showed no evidence of inflammation; however, treatment with the inducible NO synthase (iNOS) inhibitor L-N6-(1-iminoethyl) lysine dihydrochloride led to ROS generation, leukocyte-endothelial adherence and emigration, and increased vascular permeability.	ros	309-312	nitric oxide synthase 2	Rattus norvegicus	220-241
28302706-10	2017	The results support the hypothesis that the microvascular acclimatization to hypoxia results from the restoration of the ROS/NO balance mediated by iNOS expression at key sites in the inflammatory cascade.NEW &amp; NOTEWORTHY The study shows that the systemic inflammation of acute hypoxia resolves via an inducible nitric oxide (NO) synthase-induced restoration of the reactive O2 species/NO balance in the systemic microcirculation.	ros	121-124	nitric oxide synthase 2	Rattus norvegicus	148-152
28449871-2	2017	This deacetylase activates protein substrates directly involved in the production and detoxification of ROS, such as superoxide dismutase 2 and catalase, but also enzymes in the lipid beta-oxidation pathway.	ros	104-107	catalase	Homo sapiens	144-152
28646757-3	2017	Such inhibitory activity of the compounds correlated with their suppressive activities against the TNF-alpha-induced production of ROS; ICAM-1 and MCP-1 expression, critical molecules involved in monocyte-epithelial adhesion; and NF-kappaB transcriptional activity.	ros	131-134	tumor necrosis factor	Rattus norvegicus	99-108
28708509-10	2017	The present study suggests that supplementation of GDF8 during IVM synergistically improved the developmental potential of IVF- and PA-derived porcine embryos by reducing the intracellular ROS level in oocytes by altering the transcription of specific genes and increasing the phosphorylation of p38 MAPK during IVM.	ros	189-192	myostatin	Homo sapiens	51-55
28708509-11	2017	In conclusion, for the first time, our results demonstrate that GDF8 can act as a paracrine factor to modulate oocyte maturation by regulating p38 MAPK phosphorylation and intracellular ROS level during porcine IVM.	ros	186-189	myostatin	Homo sapiens	64-68
28831795-9	2017	Further, the result depicted a direct correlation between the generations of ROS with mitochondrial-dependent apoptosis through the involvement of p53 phosphorylation upon EDTFP-1 induction, suggesting this COF material is a novel chemotherapeutic agent for cancer treatment.	ros	77-80	tumor protein p53	Homo sapiens	147-150
28932171-0	2017	The role of ppargamma and autophagy in ros production, lipid droplets biogenesis and its involvement with colorectal cancer cells modulation.	ros	39-42	peroxisome proliferator activated receptor gamma	Homo sapiens	12-21
28806703-0	2017	NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.	ros	14-17	CASP8 and FADD like apoptosis regulator	Homo sapiens	81-87
28806703-8	2017	Combined treatment with curcumin and thioridazine produced intracellular ROS in a NOX4-dependent manner, and ROS-mediated activation of Nrf2/ARE signaling played a critical role in the up-regulation of PSMA5 expression.	ros	109-112	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
28823893-9	2017	Pharmacological inhibition of HDAC6 with specific inhibitor tubastatin A increased acetylation of Prx1 and Prx2, reduced ROS production and ameliorated dopaminergic neurotoxicity.	ros	121-124	histone deacetylase 6	Homo sapiens	30-35
29416738-0	2018	PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.	ros	119-122	poly(ADP-ribose) polymerase 1	Homo sapiens	0-6
29416738-0	2018	PARP-1 inhibitors sensitize HNSCC cells to APR-246 by inactivation of thioredoxin reductase 1 (TrxR1) and promotion of ROS accumulation.	ros	119-122	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	43-46
29416738-8	2018	Instead, PARP-1 inhibition promotes APR-246-facilitated inactivation of thioredoxin reductase 1 (TrxR1), leading to ROS accumulation and DNA damage.	ros	116-119	poly(ADP-ribose) polymerase 1	Homo sapiens	9-15
29416738-8	2018	Instead, PARP-1 inhibition promotes APR-246-facilitated inactivation of thioredoxin reductase 1 (TrxR1), leading to ROS accumulation and DNA damage.	ros	116-119	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	36-39
29416738-10	2018	Thus, we have characterized a new function of PARP-1 inhibitor in HNSCC cells by inactivation of TrxR1 and elevation of ROS and provide a novel therapeutic strategy for HNSCC by the combination of PARP-1 inhibitors and APR-246.	ros	120-123	poly(ADP-ribose) polymerase 1	Homo sapiens	46-52
29156799-13	2017	Mechanistically, AA attenuated I/R or LPS/H2O2-induced ROS production and phosphorylation level of JNK, p38 MAPK and IkappaBalpha but not ERK, a mechanism dependent on PPARgamma.	ros	55-58	toll-like receptor 4	Mus musculus	38-41
28755973-6	2017	Treatment with insulin alone significantly (p &lt; 0.05) reduced ROS levels as well as increased DsbA-L, adiponectin, GCLC, GCLM, GSH, and GLUT-4 protein levels, glucose utilization, and improved total and HMW adiponectin secretion in HG treated adipocytes compared to HG alone.	ros	65-68	insulin	Homo sapiens	15-22
28755973-7	2017	Interestingly, LC supplementation along with insulin caused greater reduction in ROS levels and significantly (p &lt; 0.05) boosted the DsbA-L (41% vs LC, 29% vs Insulin), adiponectin (92% Vs LC, 84% Vs insulin) protein levels and total (32% Vs LC, 22% Vs insulin) and HMW adiponectin (75% Vs LC, 39% Vs insulin) secretion compared with the either insulin or LC alone in HG-treated cells.	ros	81-84	insulin	Homo sapiens	45-52
28959260-5	2017	Nrf2- or PKR/Akt-deficient macrophages exhibited increased levels of ROS/RNS and reduced expression of Sod1 Nrf2-dependent gene and reduced parasite load.	ros	69-72	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
28959260-5	2017	Nrf2- or PKR/Akt-deficient macrophages exhibited increased levels of ROS/RNS and reduced expression of Sod1 Nrf2-dependent gene and reduced parasite load.	ros	69-72	AKT serine/threonine kinase 1	Homo sapiens	13-16
28624623-6	2017	We further found that mitochondrial fission-mediated calcium signaling was dependent on ROS-activated NF-kappaB pathways, which facilitated the expression of STIM1 and subsequent store-operated calciumentry.	ros	88-91	stromal interaction molecule 1	Homo sapiens	158-163
28712866-0	2017	Cell-free methemoglobin drives platelets to apoptosis via mitochondrial ROS-mediated activation of JNK and p38 MAP kinase.	ros	72-75	mitogen-activated protein kinase 8	Homo sapiens	99-102
28712866-0	2017	Cell-free methemoglobin drives platelets to apoptosis via mitochondrial ROS-mediated activation of JNK and p38 MAP kinase.	ros	72-75	mitogen-activated protein kinase 14	Homo sapiens	107-110
29108286-0	2017	PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway.	ros	94-97	phospholipase A2 group VI	Homo sapiens	0-6
28883439-6	2017	T cell MHP was associated with increased activation-induced IFNgamma production, and activation-induced IFNgamma was linked to mitochondria-specific ROS production.	ros	149-152	interferon gamma	Homo sapiens	104-112
29108286-0	2017	PARK14 PLA2G6 mutants are defective in preventing rotenone-induced mitochondrial dysfunction, ROS generation and activation of mitochondrial apoptotic pathway.	ros	94-97	phospholipase A2 group VI	Homo sapiens	7-13
29108286-11	2017	These results suggest that PARK14 PLA2G6 mutants lose their ability to maintain mitochondrial function and are defective inpreventing mitochondrial dysfunction, ROS production and activation of mitochondrial apoptotic pathway in rotenone-induced cellular model of PD.	ros	161-164	phospholipase A2 group VI	Homo sapiens	27-33
29108286-11	2017	These results suggest that PARK14 PLA2G6 mutants lose their ability to maintain mitochondrial function and are defective inpreventing mitochondrial dysfunction, ROS production and activation of mitochondrial apoptotic pathway in rotenone-induced cellular model of PD.	ros	161-164	phospholipase A2 group VI	Homo sapiens	34-40
28883439-8	2017	In conclusion, intrinsic mitochondrial dysfunction observed in type 1 diabetes alters mitochondrial ATP and IFNgamma production; the latter is correlated with ROS generation.	ros	159-162	interferon gamma	Homo sapiens	108-116
28552908-13	2017	In conclusion, Xyl-B administered within 2 h after the onset of stroke effectively protects against focal cerebral ischemia; the underlying mechanism may be related to suppressing the ROS/TLR4/NF-kappaB inflammatory signaling pathway.	ros	184-187	toll-like receptor 4	Mus musculus	188-192
28651126-6	2017	Moreover, AnexinV/PI analysis showed that cytotoxic effects of TNF-alpha on MCF-7/MX is mediated via apoptosis independent mechanisms and inhibition of RIP1 kinase activity using necrostatin-1 revealed that kinase activity of RIP1 plays role in the production of ROS, activation of JNK and cellular death following exposure of MCF-7/MX cells to TNF-alpha.	ros	263-266	tumor necrosis factor	Homo sapiens	63-72
28623783-6	2017	In addition, scoparoene significantly suppressed TGF-beta1-induced the expression of alpha-smooth muscle actin (alpha-SMA) and collagen I in HSC-T6 cells, as well as attenuated the expression of NADPH oxidase (NOX) isoforms expression and ROS production in TGF-beta1-stimialted HSC-T6 cells.	ros	239-242	transforming growth factor, beta 1	Rattus norvegicus	49-58
28552908-0	2017	Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-kappaB inflammatory signaling pathway.	ros	110-113	toll-like receptor 4	Mus musculus	114-118
28552908-0	2017	Xyloketal B alleviates cerebral infarction and neurologic deficits in a mouse stroke model by suppressing the ROS/TLR4/NF-kappaB inflammatory signaling pathway.	ros	110-113	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
28111709-12	2017	Further, the fluorescence intensities of ROS in the NaF groups were higher than those in the control group, and the membrane potential of mitochondria in the NaF group was significantly lower than that of the control group (P &lt; 0.05).	ros	41-44	C-X-C motif chemokine ligand 8	Homo sapiens	52-55
28437599-12	2017	Mitochondrial ROS regulated both HBD-3-induced IL-8 production and cell apoptosis.	ros	14-17	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
28370217-6	2017	The intracellular MPPa and ROS in A172 receiving MPPa-PDT significantly increased after using the ABCG2 inhibitor fumitremorgin C (FTC).	ros	27-30	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	98-103
28689919-5	2017	Regarding oxidative stress, gastrodin (20-30 muM) elevated intracellular ROS levels but reduced GSH levels.	ros	73-76	latexin	Homo sapiens	45-48
28623716-0	2017	Aldose reductase inhibitors attenuate beta-amyloid-induced TNF-alpha production in microlgia via ROS-PKC-mediated NF-kappaB and MAPK pathways.	ros	97-100	aldo-keto reductase family 1 member B	Homo sapiens	0-16
28623716-0	2017	Aldose reductase inhibitors attenuate beta-amyloid-induced TNF-alpha production in microlgia via ROS-PKC-mediated NF-kappaB and MAPK pathways.	ros	97-100	tumor necrosis factor	Homo sapiens	59-68
28623716-0	2017	Aldose reductase inhibitors attenuate beta-amyloid-induced TNF-alpha production in microlgia via ROS-PKC-mediated NF-kappaB and MAPK pathways.	ros	97-100	protein kinase C alpha	Homo sapiens	101-104
28623716-0	2017	Aldose reductase inhibitors attenuate beta-amyloid-induced TNF-alpha production in microlgia via ROS-PKC-mediated NF-kappaB and MAPK pathways.	ros	97-100	nuclear factor kappa B subunit 1	Homo sapiens	114-123
28623716-5	2017	Mechanism study showed that Sor and Zol decreased the production of intracellular ROS which resulted in an effective inhibition on the phosphorylation of several protein kinase C (PKC) isoforms including PKCalpha/beta, delta, zeta/lambda and mu.	ros	82-85	protein kinase C alpha	Homo sapiens	180-183
28623716-5	2017	Mechanism study showed that Sor and Zol decreased the production of intracellular ROS which resulted in an effective inhibition on the phosphorylation of several protein kinase C (PKC) isoforms including PKCalpha/beta, delta, zeta/lambda and mu.	ros	82-85	protein kinase C alpha	Homo sapiens	204-244
28623716-7	2017	In summary, our findings suggest that Sor and Zol could inhibit Abeta-induced neuroinflammation by regulating ROS/PKC-dependent NF-kappaB and MAPK signaling pathways, indicating that ARIs could be promising agents for treating inflammation-related neurodegenerative diseases such as AD.	ros	110-113	amyloid beta precursor protein	Homo sapiens	64-69
28623716-7	2017	In summary, our findings suggest that Sor and Zol could inhibit Abeta-induced neuroinflammation by regulating ROS/PKC-dependent NF-kappaB and MAPK signaling pathways, indicating that ARIs could be promising agents for treating inflammation-related neurodegenerative diseases such as AD.	ros	110-113	nuclear factor kappa B subunit 1	Homo sapiens	128-137
27966783-6	2017	Mitochondrial transcription factor A (TFAM) will bind and coat mtDNA, protecting it from ROS and degradation while increasing mitochondrial function.	ros	89-92	transcription factor A, mitochondrial	Homo sapiens	0-36
27966783-6	2017	Mitochondrial transcription factor A (TFAM) will bind and coat mtDNA, protecting it from ROS and degradation while increasing mitochondrial function.	ros	89-92	transcription factor A, mitochondrial	Homo sapiens	38-42
28644965-0	2017	3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.	ros	170-173	thymoma viral proto-oncogene 1	Mus musculus	197-200
28857257-10	2017	The results indicated that inhibition of miR-200a inversed the protection of Tbeta4 on H/R-CMECs, specifically including cell proliferation, cell adhesion, cell apoptosis and ROS production, as well as nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation.	ros	175-178	microRNA 200a	Homo sapiens	41-49
28820880-7	2017	Analysis of ROS in sir-2.3 knock-out reveals that ROS become elevated in this mutant under ischemic conditions in dietary deprivation (DD), but to a lesser extent than in wild type, suggesting more robust activation of a ROS scavenging system in this mutant in the absence of food.	ros	50-53	NAD-dependent protein deacylase sir-2.3	Caenorhabditis elegans	19-26
28688942-10	2017	Treatment of chondrocytes with Wogonin resulted in significant suppression of IL-1beta-mediated induction of ROS.	ros	109-112	interleukin 1 beta	Homo sapiens	78-86
28825631-7	2017	Hypoxia induces hypoxia-inducible factor and inducible nitric oxide synthase (iNOS), which increases the levels of intracellular RNS and ROS, resulting DNA damage in progression with poor prognosis.	ros	137-140	nitric oxide synthase 2	Homo sapiens	78-82
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	33-36	tumor protein p53	Homo sapiens	146-149
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	33-36	AKT serine/threonine kinase 1	Homo sapiens	159-162
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	91-94	tumor protein p53	Homo sapiens	146-149
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	91-94	AKT serine/threonine kinase 1	Homo sapiens	159-162
28852176-6	2017	S17 robustly induced generation of ROS with Keap/Nrf2 pathway activated and the application of ROS scavenger N-acetyl cysteine (NAC) completely blocked these effects by S17 in MGC803 cells.	ros	35-38	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
28714505-4	2017	To this end, we assessed its effect on catalase from erythrocytes and found evidence of inhibition, which was further confirmed by ROS determination in vivo.	ros	131-134	catalase	Homo sapiens	39-47
28820880-7	2017	Analysis of ROS in sir-2.3 knock-out reveals that ROS become elevated in this mutant under ischemic conditions in dietary deprivation (DD), but to a lesser extent than in wild type, suggesting more robust activation of a ROS scavenging system in this mutant in the absence of food.	ros	12-15	NAD-dependent protein deacylase sir-2.3	Caenorhabditis elegans	19-26
28820880-7	2017	Analysis of ROS in sir-2.3 knock-out reveals that ROS become elevated in this mutant under ischemic conditions in dietary deprivation (DD), but to a lesser extent than in wild type, suggesting more robust activation of a ROS scavenging system in this mutant in the absence of food.	ros	50-53	NAD-dependent protein deacylase sir-2.3	Caenorhabditis elegans	19-26
28551376-0	2017	Regulation of Na+-K+-ATPase effected high glucose-induced myocardial cell injury through c-Src dependent NADPH oxidase/ROS pathway.	ros	119-122	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	89-94
28861175-0	2017	The STAT3 inhibitor pimozide impedes cell proliferation and induces ROS generation in human osteosarcoma by suppressing catalase expression.	ros	68-71	signal transducer and activator of transcription 3	Homo sapiens	4-9
28861175-9	2017	Importantly, pimozide induced ROS generation by downregulating the expression of the antioxidant enzyme catalase (CAT).	ros	30-33	catalase	Homo sapiens	114-117
28551376-9	2017	Na+-K+-ATPase c-Src dependent NADPH oxidase/ROS pathway was also involved in the effects of ouabain and DRm217 on HG-induced cell injury.	ros	44-47	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
28583762-0	2017	Puerarin inhibits amyloid beta-induced NLRP3 inflammasome activation in retinal pigment epithelial cells via suppressing ROS-dependent oxidative and endoplasmic reticulum stresses.	ros	121-124	NLR family pyrin domain containing 3	Homo sapiens	39-44
28583762-5	2017	The results showed that Abeta1-40 induced NLRP3 inflammasome activation mainly via triggering ROS-dependent oxidative stress, particularly lipid peroxidation, and endoplasmic reticulum stress in LPS-primed ARPE-19 cells; however, such effect could be significantly reversed by puerarin in a dose-dependent manner.	ros	94-97	NLR family pyrin domain containing 3	Homo sapiens	42-47
29088809-0	2017	Anti-inflammatory effects of millet bran derived-bound polyphenols in LPS-induced HT-29 cell via ROS/miR-149/Akt/NF-kappaB signaling pathway.	ros	97-100	nuclear factor kappa B subunit 1	Homo sapiens	113-122
29088809-5	2017	Further, we found the elevated miR-149 expression by BPIS-induced ROS accumulation, directly targeted the Akt expression to block NF-kappaB nuclear translocation.	ros	66-69	AKT serine/threonine kinase 1	Homo sapiens	106-109
29088809-5	2017	Further, we found the elevated miR-149 expression by BPIS-induced ROS accumulation, directly targeted the Akt expression to block NF-kappaB nuclear translocation.	ros	66-69	nuclear factor kappa B subunit 1	Homo sapiens	130-139
29088809-6	2017	Taken together, these novel findings provide new insights into the development of BPIS as an anti-inflammatory agent via the signaling cascade of ROS/miR-149/Akt/NF-kappaB axis.	ros	146-149	nuclear factor kappa B subunit 1	Homo sapiens	162-171
28824425-7	2017	Furthermore, Rb1 pretreatment could inhibit TNF-alpha-induced ROS and MDA production; increase the activities of SOD, CAT, and GSH-Px; and decrease the levels of IL-1beta, IL-6, VCAM-1, ICAM-1, VEGF, MMP-2 and MMP-9.	ros	62-65	tumor necrosis factor	Homo sapiens	44-53
29348836-7	2017	Consequently, HSF-1 hyperphosphorylation mediated by JNK operation causes transcriptional inactivation of HSF-1, and supported ROS-mediated autophagy induction.	ros	127-130	mitogen-activated protein kinase 8	Homo sapiens	53-56
28796811-3	2017	Here we showed that increased BH3-only protein BIK levels promoted cisplatin- and UV-induced mitochondrial apoptosis and biphasic ROS production in HCT-116 wild-type cells.	ros	130-133	BCL2 interacting killer	Homo sapiens	47-50
28796811-4	2017	Nonetheless, early single peak of ROS formation along with lysosomal membrane permeabilization and cathepsin activation regulated cisplatin- and UV-induced necrosis in p53-null HCT-116 cells.	ros	34-37	tumor protein p53	Homo sapiens	168-171
28109089-0	2017	Betulinic Acid Inhibits Cell Proliferation in Human Oral Squamous Cell Carcinoma via Modulating ROS-Regulated p53 Signaling.	ros	96-99	tumor protein p53	Homo sapiens	110-113
28109089-13	2017	Taken together, the data demonstrated that ROS-p53 signaling was crucial for BA-exhibited antitumor effect in OSCC.	ros	43-46	tumor protein p53	Homo sapiens	47-50
29069806-0	2017	Modulating BAP1 expression affects ROS homeostasis, cell motility and mitochondrial function.	ros	35-38	BRCA1 associated protein 1	Homo sapiens	11-15
28768915-4	2017	Doxorubicin increased production of ROS in rodent cardiomyocytes through hypoxic stress-mediated upregulation of NADPH oxidase 2 (Nox2), which formed a stable complex with TRPC3.	ros	36-39	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	172-177
28915557-8	2017	One biological consequence of elevated ROS in p16-deficient PMFs was enhanced migration, which was reduced by the ROS scavenger N-acetylcysteine.	ros	39-42	cyclin dependent kinase inhibitor 2A	Homo sapiens	46-49
28915557-8	2017	One biological consequence of elevated ROS in p16-deficient PMFs was enhanced migration, which was reduced by the ROS scavenger N-acetylcysteine.	ros	114-117	cyclin dependent kinase inhibitor 2A	Homo sapiens	46-49
28618649-3	2017	An increase in CD11b and CD15 differentiation markers with attenuated ROS generation was also observed in Cafestol-treated HL60 cells.	ros	70-73	fucosyltransferase 4	Homo sapiens	25-29
28108421-11	2017	Taken together, these data showed that TLR4 knockout ameliorated high fat diet-induced cardiac contractile and intracellular Ca2+ anomalies through inhibition of inflammation and ROS, possibly through a NF-kappaB/JNK-dependent activation of autophagy.	ros	179-182	toll-like receptor 4	Mus musculus	39-43
28554130-7	2017	B10 caused a significant decrease in mitochondrial oxygen consumption rate, mitochondrial complex I, II, III, IV, and V activities, and ATP level, and increase of mitochondrial ROS production, indicating the induction of mitochondrial dysfunction.	ros	177-180	granzyme C	Mus musculus	0-3
28575806-0	2017	Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549).	ros	15-18	TNF superfamily member 10	Homo sapiens	92-97
28571773-0	2017	DATS sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 via ROS.	ros	98-101	TNF superfamily member 10	Homo sapiens	32-37
28571773-6	2017	In addition, DATS enhances TRAIL-induced apoptosis through the downregulation of anti-apoptotic protein (Mcl-1) and the upregulation of DR5 receptors through actions on the ROS- induced-p53.	ros	173-176	TNF superfamily member 10	Homo sapiens	27-32
28571773-6	2017	In addition, DATS enhances TRAIL-induced apoptosis through the downregulation of anti-apoptotic protein (Mcl-1) and the upregulation of DR5 receptors through actions on the ROS- induced-p53.	ros	173-176	tumor protein p53	Homo sapiens	186-189
28321581-8	2017	Imbalanced levels of ROS generation and antioxidant defence mechanism (superoxide dismutase and catalase) cause damages to lipids, proteins and DNA.	ros	21-24	catalase	Mus musculus	96-104
28718669-8	2017	We also showed fruit polyphenol-mediated release of mitochondrial pro- and antiapoptotic proteins of the Bcl-2 family and modulation activity of the Akt, p38 MAPK, and Erk 1/2 pathways as well as the signaling of ROS-mediated DNA damage.	ros	213-216	BCL2 apoptosis regulator	Homo sapiens	105-110
28285191-0	2017	Polychlorinated biphenyls-153 induces metabolic dysfunction through activation of ROS/NF-kappaB signaling via downregulation of HNF1b.	ros	82-85	HNF1 homeobox B	Homo sapiens	128-133
28591670-9	2017	Western blot analysis showed that compound 5b induces G2/M phase arrest via ROS mediated DNA-damage, which in turn, induces phosphorylation of Chk1/Cdc25c/Cdc2 pathway.	ros	76-79	checkpoint kinase 1	Homo sapiens	143-147
28591670-10	2017	Furthermore, altered levels of ROS triggers intrinsic apoptotic cascade, as evidenced by dissipated mitochondrial membrane potential (psi), decrease in Bcl-2/Bax ratio, cytochrome c release and cleavage of procaspase-3.	ros	31-34	BCL2 apoptosis regulator	Homo sapiens	152-157
28591670-10	2017	Furthermore, altered levels of ROS triggers intrinsic apoptotic cascade, as evidenced by dissipated mitochondrial membrane potential (psi), decrease in Bcl-2/Bax ratio, cytochrome c release and cleavage of procaspase-3.	ros	31-34	BCL2 associated X, apoptosis regulator	Homo sapiens	158-161
28591670-10	2017	Furthermore, altered levels of ROS triggers intrinsic apoptotic cascade, as evidenced by dissipated mitochondrial membrane potential (psi), decrease in Bcl-2/Bax ratio, cytochrome c release and cleavage of procaspase-3.	ros	31-34	cytochrome c, somatic	Homo sapiens	169-181
28591670-10	2017	Furthermore, altered levels of ROS triggers intrinsic apoptotic cascade, as evidenced by dissipated mitochondrial membrane potential (psi), decrease in Bcl-2/Bax ratio, cytochrome c release and cleavage of procaspase-3.	ros	31-34	caspase 3	Homo sapiens	206-218
28285191-9	2017	Overexpression of HNF1b increased GPx1 expression, decreased ROS level, decreased Srebp1, ACC and FAS expression, and inhibited PCB-153-resulted oxidative stress, NF-kappaB-mediated inflammation, and final glucose/lipid metabolic disorder.	ros	61-64	HNF1 homeobox B	Homo sapiens	18-23
28285191-10	2017	Our results suggest that dysregulation of HNF1b/ROS/NF-kappaB plays an important role in PCB-153-induced glucose/lipid metabolic disorder.	ros	48-51	HNF1 homeobox B	Homo sapiens	42-47
28288414-4	2017	In this study, the role of miR-22 in butyrate-mediated ROS release and induction of apoptosis was determined in hepatic cells.	ros	55-58	microRNA 22	Homo sapiens	27-33
28288414-6	2017	Over-expression of miR-22 or addition of sodium butyrate inhibited SIRT-1 expression and enhanced the ROS production.	ros	102-105	microRNA 22	Homo sapiens	19-25
28765650-8	2017	Absence of REDD1 decreases ROS associated with a dysregulation of Nox-1 and GPx3 expression.	ros	27-30	DNA-damage-inducible transcript 4	Mus musculus	11-16
28292711-0	2017	CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression.	ros	127-130	angiotensinogen	Homo sapiens	40-54
28292711-0	2017	CO-releasing molecules CORM2 attenuates angiotensin II-induced human aortic smooth muscle cell migration through inhibition of ROS/IL-6 generation and matrix metalloproteinases-9 expression.	ros	127-130	interleukin 6	Homo sapiens	131-135
28547744-0	2017	Bacterial fMLP Modulates Both ROS and Chemotaxis.	ros	30-33	formyl peptide receptor 1	Homo sapiens	10-14
28765527-8	2017	These findings suggest that insulin secretion in pancreatic cells is regulated by Ca2+ and ROS signaling through Ca2+-induced structural changes promoting dimerization of hSCGN.	ros	91-94	insulin	Homo sapiens	28-35
28288414-0	2017	Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells.	ros	17-20	microRNA 22	Homo sapiens	54-60
28698499-3	2017	Reactive oxygen and nitrogen species (ROS and RNS, respectively), collectively known as RONS, are produced by cellular enzymes such as myeloperoxidase, NADPH-oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) and nitric oxide synthase (NOS).	ros	38-41	nitric oxide synthase 2	Homo sapiens	224-245
28743882-7	2017	In addition, hyperoside pre-treatment inhibited the increased heparanase gene (HPR1) promoter activity and heparanase expression induced by high glucose or reactive oxidative species (ROS) in cultured podocytes.	ros	184-187	heparanase	Mus musculus	79-83
28740091-4	2017	Importantly, we demonstrated that the expression of TRMU, GTPBP3 and MTO1 is regulated by different miRNAs, which are induced by retrograde signals like ROS and Ca2+ via different pathways.	ros	153-156	tRNA mitochondrial 2-thiouridylase	Homo sapiens	52-56
28636040-6	2017	Overproduction of ROS resulted in a strong decrease in the mitochondrial membrane potential, translocation of cytochrome c to the cytosol and activation of caspase 3, thus leading to apoptosis.	ros	18-21	cytochrome c, somatic	Homo sapiens	110-122
28636040-6	2017	Overproduction of ROS resulted in a strong decrease in the mitochondrial membrane potential, translocation of cytochrome c to the cytosol and activation of caspase 3, thus leading to apoptosis.	ros	18-21	caspase 3	Homo sapiens	156-165
28720802-0	2017	A novel ADOA-associated OPA1 mutation alters the mitochondrial function, membrane potential, ROS production and apoptosis.	ros	93-96	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	24-28
28460338-4	2017	Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells.	ros	130-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-60
28770953-11	2017	Overexpression of miR-200c increased the ROS levels under H2O2.	ros	41-44	microRNA 200c	Rattus norvegicus	18-26
28495448-8	2017	Our study demonstrates for the first time that KC provided a rescue effect on UVB-mediated MC damage, although depletion of Nrf2 in KC reversed its protective effects on MC in a paracrine fashion in association with elevation of ROS levels and activation of MAPK pathways in MC.	ros	229-232	NFE2 like bZIP transcription factor 2	Homo sapiens	124-128
28495448-9	2017	Nrf2 may indirectly regulate the paracrine effects of KC probably by affecting levels of the paracrine factor alpha-MSH via a ROS-dependent mechanism.	ros	126-129	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
28495448-9	2017	Nrf2 may indirectly regulate the paracrine effects of KC probably by affecting levels of the paracrine factor alpha-MSH via a ROS-dependent mechanism.	ros	126-129	proopiomelanocortin	Homo sapiens	110-119
28495310-8	2017	Finally, we demonstrated that PM enhanced NF-kappaB p65 phosphorylation and the NF-kappaB promoter activity, which were reduced by pretreatment with a ROS inhibitor or resveratrol.	ros	151-154	nuclear factor kappa B subunit 1	Homo sapiens	42-51
28495310-8	2017	Finally, we demonstrated that PM enhanced NF-kappaB p65 phosphorylation and the NF-kappaB promoter activity, which were reduced by pretreatment with a ROS inhibitor or resveratrol.	ros	151-154	nuclear factor kappa B subunit 1	Homo sapiens	80-89
28169456-4	2017	The effects of DADS on IL-1beta-induced intracellular ROS production and lipid peroxidation were detected and the proteins expression of Nrf2, Bax, Bcl-2, caspase-3, total and phosphorylated JNK, and P38 MAPKs were analyzed by Western blotting.	ros	54-57	interleukin 1 beta	Homo sapiens	23-31
28460338-0	2017	Iron overload promotes erythroid apoptosis through regulating HIF-1a/ROS signaling pathway in patients with myelodysplastic syndrome.	ros	69-72	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-68
28526948-7	2017	Thus, overexpression of MRPS18C gene (that encode for bS18m protein) suppressed the molecular defects produced by this mtDNA mutation, recovering the complex I activity and reducing the ROS produced by this complex to normal levels.	ros	186-189	mitochondrial ribosomal protein S18C	Homo sapiens	24-31
28495310-0	2017	Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-kappaB.	ros	161-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
28460338-4	2017	Interestingly, overexpression of hypoxia inducible factor-1a (HIF-1a), which was under-expressed in iron overload models, reduced ROS levels and attenuated cell damage caused by iron overload in MDS/AML cells.	ros	130-133	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-68
28460338-7	2017	Importantly, the HIF-1a protein levels of erythrocytes elevated obviously after incubation with desferrioxamine (DFO) from MDS patients with iron overload, accompanied by ROS levels inhibited and erythroid apoptosis reduced.	ros	171-174	hypoxia inducible factor 1 subunit alpha	Homo sapiens	17-23
28460338-8	2017	Taken together, our findings determine that the HIF-1a/ROS signaling pathway plays a key role in promoting erythroid apoptosis in MDS patients with iron overload.	ros	55-58	hypoxia inducible factor 1 subunit alpha	Homo sapiens	48-54
28968982-5	2017	The restoration of BNIP3 expression in pancreatic cancer cells in vitro, caused loss of DeltaPsim, increase in ROS production, and apoptosis induction.	ros	111-114	BCL2 interacting protein 3	Homo sapiens	19-24
27181592-0	2017	JNK Activation Contributes to Oxidative Stress-Induced Parthanatos in Glioma Cells via Increase of Intracellular ROS Production.	ros	113-116	mitogen-activated protein kinase 8	Homo sapiens	0-3
27181592-9	2017	Additionally, inhibition of JNK with SP600125 alleviated intracellular accumulation of ROS and attenuated mitochondrial generation of superoxide.	ros	87-90	mitogen-activated protein kinase 8	Homo sapiens	28-31
27181592-10	2017	Thus, we demonstrated that JNK activation contributes to glioma cell parthanatos caused by oxidative stress via increase of intracellular ROS generation.	ros	138-141	mitogen-activated protein kinase 8	Homo sapiens	27-30
28840690-8	2017	That is, PPL could lead to inflammatory cascade reaction by promoting the maturation and secretion of IL-1beta through ROS-TXNIP-NLRP3-IL-1beta signaling pathway.	ros	119-122	interleukin 1 beta	Mus musculus	102-110
28661486-1	2017	c-Jun N-terminal kinase (JNK) mediates hepatotoxicity through interaction of its phospho-activated form with a mitochondrial outer membrane protein, Sh3bp5 or Sab, leading to dephosphorylation of intermembrane Src and consequent impaired mitochondrial respiration and enhanced ROS release.	ros	277-280	voltage-dependent anion channel 3	Mus musculus	111-147
28661486-1	2017	c-Jun N-terminal kinase (JNK) mediates hepatotoxicity through interaction of its phospho-activated form with a mitochondrial outer membrane protein, Sh3bp5 or Sab, leading to dephosphorylation of intermembrane Src and consequent impaired mitochondrial respiration and enhanced ROS release.	ros	277-280	SH3-domain binding protein 5 (BTK-associated)	Mus musculus	149-155
28218450-4	2017	In this study, we demonstrated that upon Cr(VI) treatment, the intracellular receptor src was activated, which further upregulated Ras activity, leading to the augmentation of ROS and onset of ER stress in human lung epithelial BEAS-2B or keratinocytes.	ros	176-179	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	86-89
28978049-0	2017	ROS-independent Nrf2 activation in prostate cancer.	ros	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	16-20
28465253-11	2017	CONCLUSIONS: These results demonstrate that the suppressive effect of CMEP-NQ on LPS-induced inflammatory responses in RAW264.7 cells was mainly exerted via its inhibition of TLR4-mediated proximal events, such as MyD88-dependent NF-kappaB/AP-1 activation and ROS production, and TRIF-dependent IRF3 activation.	ros	260-263	toll-like receptor 4	Mus musculus	175-179
28467805-8	2017	PON1 promoted ROS deregulation protecting the mitochondria from dysregulation.	ros	14-17	paraoxonase 1	Homo sapiens	0-4
28680404-8	2017	Intriguingly, the reduction of ROS was found in concerted with the activation of Nrf2 and HO-1.	ros	31-34	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
28680404-8	2017	Intriguingly, the reduction of ROS was found in concerted with the activation of Nrf2 and HO-1.	ros	31-34	heme oxygenase 1	Mus musculus	90-94
28410217-11	2017	Pterostilbene inhibited the level of COX-2, iNOS, PGE2, and NO, as well as the mitochondrial and total intracellular ROS production induced by IL-1beta in chondrocytes, partially reversed by the Nrf2 silencing.	ros	117-120	interleukin 1 beta	Rattus norvegicus	143-151
28410217-13	2017	These results suggest that pterostilbene could inhibit the IL-1beta-induced inflammation and ROS production in chondrocytes by stimulating the nuclear translocation of Nrf2.	ros	93-96	interleukin 1 beta	Rattus norvegicus	59-67
28410217-13	2017	These results suggest that pterostilbene could inhibit the IL-1beta-induced inflammation and ROS production in chondrocytes by stimulating the nuclear translocation of Nrf2.	ros	93-96	NFE2 like bZIP transcription factor 2	Rattus norvegicus	168-172
28489580-3	2017	Here we demonstrate that autophagy induction by rapamycin suppressed the production of IL-1beta and IL-18 in lipopolysaccharide- and adenosine triphosphate-activated macrophages at the post-transcriptional level by eliminating mitochondrial ROS (mtROS) and pro-IL1beta in a p62/SQSTM1-dependent manner.	ros	241-244	interleukin 1 beta	Homo sapiens	87-95
28593945-3	2017	Upon NOD2 stimulation of human macrophages, LACC1 associates with the NOD2-signalling complex, and is critical for optimal NOD2-induced signalling, mitochondrial ROS (mtROS) production, cytokine secretion and bacterial clearance.	ros	162-165	laccase domain containing 1	Homo sapiens	44-49
28598396-5	2017	At the same time Nrf2/HO-1 pathway is up-regulated by ROS to protect placenta cells from oxidative damage.	ros	54-57	NFE2 like bZIP transcription factor 2	Homo sapiens	17-21
26660451-4	2017	Thus, the consequences of the interaction (redox crosstalk) of superoxide/hydrogen peroxide produced by mitochondria with other ROS producing enzymes such as NADPH oxidases (Nox) are of outstanding importance and will be discussed including the consequences for endothelial nitric oxide synthase (eNOS) uncoupling as well as the redox regulation of the vascular function/tone in general (soluble guanylyl cyclase, endothelin-1, prostanoid synthesis).	ros	128-131	nitric oxide synthase 3	Homo sapiens	262-295
28537474-6	2017	ERF71 and ERF73 may have a role in supervising plant intracellular ROS homeostasis, whereas ERF72 may only act as an activator of ERF74 and ERF75 in the stress response.	ros	67-70	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	10-15
28185435-7	2017	I suggest that this increasing ATP deficit is communicated by progressive increases in mitochondrial ROS generation, which signals inhibition of mitophagy via ROS-dependent activation of insulin signaling.	ros	101-104	insulin	Homo sapiens	187-194
28185435-7	2017	I suggest that this increasing ATP deficit is communicated by progressive increases in mitochondrial ROS generation, which signals inhibition of mitophagy via ROS-dependent activation of insulin signaling.	ros	159-162	insulin	Homo sapiens	187-194
28306139-9	2017	AS-1 inhibited the MCD diet-induced activation of caspase 1 and the NLRP3-ASC inflammasome, and also reduced the enhanced levels of ROS, malondialdehyde, 3-nitrotyrosine, NADPH oxidase complex and CYP reductase-associated cytochrome p450 2E1 (CYP2E1) expression in the liver.	ros	132-135	arylsulfatase B	Mus musculus	0-4
28306139-10	2017	In addition, AS-1 decreased ROS, inflammasome activation and IL-1beta production in free fatty acid-LPS-treated Kupffer cells.	ros	28-31	arylsulfatase B	Mus musculus	13-17
26660451-4	2017	Thus, the consequences of the interaction (redox crosstalk) of superoxide/hydrogen peroxide produced by mitochondria with other ROS producing enzymes such as NADPH oxidases (Nox) are of outstanding importance and will be discussed including the consequences for endothelial nitric oxide synthase (eNOS) uncoupling as well as the redox regulation of the vascular function/tone in general (soluble guanylyl cyclase, endothelin-1, prostanoid synthesis).	ros	128-131	endothelin 1	Homo sapiens	414-426
28336091-5	2017	The CYP2E1 inhibitor chlormethiazole inhibited ROS generation, mitochondrial membrane potential loss, caspase-3 activity, and cytotoxicity caused by MC-LR.	ros	47-50	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	4-10
28587419-9	2017	This study suggested that the AngII-p22phox-ROS signaling pathway, PPARgamma and OGG1 together contributed to the hyperoxia-induced lung injury and that NK3201 was able to reverse the effects of hyperoxia.	ros	44-47	angiotensinogen	Rattus norvegicus	30-35
28587378-6	2017	LA activated Akt signaling and inhibition of Akt signaling abolished the effects of LA on cell viability, NO production, ROS production and ATP levels in UA-treated endothelial cells.	ros	121-124	AKT serine/threonine kinase 1	Rattus norvegicus	45-48
28587419-9	2017	This study suggested that the AngII-p22phox-ROS signaling pathway, PPARgamma and OGG1 together contributed to the hyperoxia-induced lung injury and that NK3201 was able to reverse the effects of hyperoxia.	ros	44-47	cytochrome b-245 alpha chain	Rattus norvegicus	36-43
28488794-0	2017	Apoptotic Activity of Lactobacillus plantarum DGK-17-Fermented Soybean Seed Extract in Human Colon Cancer Cells via ROS-JNK Signaling Pathway.	ros	116-119	mitogen-activated protein kinase 8	Homo sapiens	120-123
28508124-5	2017	The increased expression of DNA methyltransferases following the activation of ROS/ERK1/2 signaling was responsible for the DNA hypermethylation of sFRP5 induced by indoxyl sulfate.	ros	79-82	mitogen-activated protein kinase 3	Homo sapiens	83-89
28508124-5	2017	The increased expression of DNA methyltransferases following the activation of ROS/ERK1/2 signaling was responsible for the DNA hypermethylation of sFRP5 induced by indoxyl sulfate.	ros	79-82	secreted frizzled related protein 5	Homo sapiens	148-153
28508124-12	2017	ROS/ERK1/2 signaling activation is involved in IS-induced sFRP5 hypermethylation.	ros	0-3	secreted frizzled related protein 5	Homo sapiens	58-63
28267592-7	2017	Results demonstrate that sFRP4 causes endothelial dysfunction by suppressing NO-cGMP signaling and elevating corresponding ROS levels.	ros	123-126	secreted frizzled related protein 4	Homo sapiens	25-30
28414076-8	2017	Furthermore, when cells were transfected with shRNA-TrxR2, the production of ROS was significantly increased, and SOD, CAT and GSH-Px activity was decreased.	ros	77-80	thioredoxin reductase 2	Homo sapiens	52-57
28414076-11	2017	The inhibition of TrxR2 suppressed lung cancer cell proliferation, invasion and migration and induced cell apoptosis by inducing ROS production and decreasing antioxidant activity.	ros	129-132	thioredoxin reductase 2	Homo sapiens	18-23
28511903-11	2017	In spite of a low direct antioxidant capacity, both compounds reduced intracellular ROS levels generated by treatment of TNFalpha but only BBR inhibited NOX2 expression, MAPK/Erk1/2 signaling and subsequent NF-kappaB target genes VCAM and ICAM expression, induced by TNFalpha.	ros	84-87	tumor necrosis factor	Homo sapiens	121-129
28536473-9	2017	Moreover, AMC provoked the production of ROS, H2O2, and NO, modulating the PI3K/Akt, MAPK, NFkappaB and Nrf2 pathways and their downstream transcriptional cascades, ultimately evoked oxidative stress and apoptosis in HpeG2 cells.	ros	41-44	AKT serine/threonine kinase 1	Homo sapiens	80-83
28546552-7	2017	Additionally, melatonin treatment attenuated pathological changes in mitochondria and reduced ROS generation, which are closely related to NLRP3 inflammasome activation.	ros	94-97	NLR family, pyrin domain containing 3	Rattus norvegicus	139-144
28440462-0	2017	Imperatorin efficiently blocks TNF-alpha-mediated activation of ROS/PI3K/Akt/NF-kappaB pathway.	ros	64-67	tumor necrosis factor	Homo sapiens	31-40
28440462-0	2017	Imperatorin efficiently blocks TNF-alpha-mediated activation of ROS/PI3K/Akt/NF-kappaB pathway.	ros	64-67	AKT serine/threonine kinase 1	Homo sapiens	73-76
28440462-0	2017	Imperatorin efficiently blocks TNF-alpha-mediated activation of ROS/PI3K/Akt/NF-kappaB pathway.	ros	64-67	nuclear factor kappa B subunit 1	Homo sapiens	77-86
28440462-6	2017	Furthermore, our findings show that imperatorin inhibits TNF-alpha-induced ROS generation.	ros	75-78	tumor necrosis factor	Homo sapiens	57-66
28440462-7	2017	Taken together, imperatorin can blunt inflammation by inhibiting the ROS-mediated activation of the PI3K/Akt/NF-kappaB pathway.	ros	69-72	AKT serine/threonine kinase 1	Homo sapiens	105-108
28440462-7	2017	Taken together, imperatorin can blunt inflammation by inhibiting the ROS-mediated activation of the PI3K/Akt/NF-kappaB pathway.	ros	69-72	nuclear factor kappa B subunit 1	Homo sapiens	109-118
28440491-0	2017	TXNIP overexpression suppresses proliferation and induces apoptosis in SMMC7221 cells through ROS generation and MAPK pathway activation.	ros	94-97	thioredoxin interacting protein	Homo sapiens	0-5
28440491-6	2017	Moreover, TXNIP over-expression inhibited hepatocellular carcinoma cell proliferation and induced apoptosis by triggering mitochondrial-mediated ROS generation and activating MAPK pathways.	ros	145-148	thioredoxin interacting protein	Homo sapiens	10-15
28536473-9	2017	Moreover, AMC provoked the production of ROS, H2O2, and NO, modulating the PI3K/Akt, MAPK, NFkappaB and Nrf2 pathways and their downstream transcriptional cascades, ultimately evoked oxidative stress and apoptosis in HpeG2 cells.	ros	41-44	nuclear factor kappa B subunit 1	Homo sapiens	91-99
28536473-9	2017	Moreover, AMC provoked the production of ROS, H2O2, and NO, modulating the PI3K/Akt, MAPK, NFkappaB and Nrf2 pathways and their downstream transcriptional cascades, ultimately evoked oxidative stress and apoptosis in HpeG2 cells.	ros	41-44	NFE2 like bZIP transcription factor 2	Homo sapiens	104-108
28518151-0	2017	Disulfiram/copper selectively eradicates AML leukemia stem cells in vitro and in vivo by simultaneous induction of ROS-JNK and inhibition of NF-kappaB and Nrf2.	ros	115-118	mitogen-activated protein kinase 8	Homo sapiens	119-122
28518151-8	2017	Mechanistically, DS/Cu-induced cytotoxicity was closely associated with activation of the stress-related ROS-JNK pathway as well as simultaneous inactivation of the pro-survival Nrf2 and nuclear factor-kappaB pathways.	ros	105-108	mitogen-activated protein kinase 8	Homo sapiens	109-112
28516914-5	2017	Mechanistically, hCINAP binds to the C-terminal domain of LDHA, the key regulator of glycolysis, and depends on its adenylate kinase activity to promote LDHA phosphorylation at tyrosine 10, resulting in the hyperactive Warburg effect and the lower cellular ROS level and conferring metabolic advantage to CRCSC invasion.	ros	257-260	lactate dehydrogenase A	Homo sapiens	58-62
28516914-5	2017	Mechanistically, hCINAP binds to the C-terminal domain of LDHA, the key regulator of glycolysis, and depends on its adenylate kinase activity to promote LDHA phosphorylation at tyrosine 10, resulting in the hyperactive Warburg effect and the lower cellular ROS level and conferring metabolic advantage to CRCSC invasion.	ros	257-260	lactate dehydrogenase A	Homo sapiens	153-157
28638454-5	2017	Mechanistically, SSBP1 loss induced mitochondrial dysfunction via decreasing mitochondrial DNA copy number and ATP generation, enhancing the mitochondrial-derived ROS accumulation and downregulating key glycolytic enzymes expression.	ros	163-166	nucleic acid binding protein 2	Homo sapiens	17-22
29088756-7	2017	The ROS, produced by DHS activated the p38 and JNK MAPKs to augment the BAX activity and BID-cleavage, and induce LMP and MMP in the cells.	ros	4-7	mitogen-activated protein kinase 14	Homo sapiens	39-42
29088756-7	2017	The ROS, produced by DHS activated the p38 and JNK MAPKs to augment the BAX activity and BID-cleavage, and induce LMP and MMP in the cells.	ros	4-7	mitogen-activated protein kinase 8	Homo sapiens	47-50
29088756-7	2017	The ROS, produced by DHS activated the p38 and JNK MAPKs to augment the BAX activity and BID-cleavage, and induce LMP and MMP in the cells.	ros	4-7	BCL2 associated X, apoptosis regulator	Homo sapiens	72-75
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	43-46	regulator of G protein signaling 1	Homo sapiens	140-144
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 1	Homo sapiens	140-144
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 1	Homo sapiens	140-144
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 1	Homo sapiens	140-144
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 1	Homo sapiens	140-144
28505160-6	2017	Gene-specific knockdown of NRF2 improved sensitivity to these drugs in resistant AML cell lines by decreasing the expression of downstream antioxidant targets of Nrf2 by compromising the cell"s ability to scavenge the ROS.	ros	218-221	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
28505160-9	2017	This study demonstrates that Nrf2 could be an ideal druggable target in AML, more so to the drugs that function through ROS, suggesting the possibility of using Nrf2 inhibitors in combination with chemotherapeutic agents to modulate drug resistance in AML.	ros	120-123	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
28505160-9	2017	This study demonstrates that Nrf2 could be an ideal druggable target in AML, more so to the drugs that function through ROS, suggesting the possibility of using Nrf2 inhibitors in combination with chemotherapeutic agents to modulate drug resistance in AML.	ros	120-123	NFE2 like bZIP transcription factor 2	Homo sapiens	161-165
28237856-7	2017	Instead, Wogonin induced mild oxidative stress through the generation of ROS and depletion of cellular GSH, thereby modulating the cellular redox leading to the induction of Nrf2/ARE pathways through activation of ROS/ERK/Nrf2/HO-1-SOD2-NQO1-GCLC signaling axis in OA chondrocytes.	ros	214-217	NFE2 like bZIP transcription factor 2	Homo sapiens	174-178
28358255-0	2017	The IFN-1 &gt; BID &gt; ROS pathway: Linking DNA damage with HSPC malfunction.	ros	24-27	IFN1@	Homo sapiens	4-9
28358255-0	2017	The IFN-1 &gt; BID &gt; ROS pathway: Linking DNA damage with HSPC malfunction.	ros	24-27	BH3 interacting domain death agonist	Homo sapiens	15-18
28034666-6	2017	Considering that iNOS expression is regulated by nuclear factor-kappaB, which may be activated by ROS, antioxidants could inhibit the overexpression of iNOS in sepsis.	ros	98-101	nitric oxide synthase 2	Homo sapiens	17-21
28034666-6	2017	Considering that iNOS expression is regulated by nuclear factor-kappaB, which may be activated by ROS, antioxidants could inhibit the overexpression of iNOS in sepsis.	ros	98-101	nitric oxide synthase 2	Homo sapiens	152-156
28255993-0	2017	Curcuminoid EF24 enhances the anti-tumour activity of Akt inhibitor MK-2206 through ROS-mediated endoplasmic reticulum stress and mitochondrial dysfunction in gastric cancer.	ros	84-87	AKT serine/threonine kinase 1	Homo sapiens	54-57
28255993-12	2017	CONCLUSION AND IMPLICATIONS: Targeting ROS generation by using a combination of an Akt inhibitor and EF24 could have potential as a therapy for gastric cancer.	ros	39-42	AKT serine/threonine kinase 1	Homo sapiens	83-86
28267517-4	2017	CPS-A also played a protective role against TNF-alpha induced L02 cells apoptosis via up-regulation of Bcl-2 and down-regulation of Bid, Bax, cleaved caspase-3, cleaved caspase-9 and ROS production.	ros	183-186	tumor necrosis factor	Homo sapiens	44-53
28267517-6	2017	In conclusion, CPS-A was involved in TNF-alpha induced mitochondria abnormality via TNFR1/ROS/Mfn2 pathway.	ros	90-93	tumor necrosis factor	Homo sapiens	37-46
28411855-0	2017	Single molecule force spectroscopy for in-situ probing oridonin inhibited ROS-mediated EGF-EGFR interactions in living KYSE-150 cells.	ros	74-77	epidermal growth factor receptor	Homo sapiens	91-95
28482716-0	2017	Dihydromyricetin induces apoptosis and cytoprotective autophagy through ROS-NF-kappaB signalling in human melanoma cells.	ros	72-75	nuclear factor kappa B subunit 1	Homo sapiens	76-85
28482716-6	2017	Moreover, N-acetyl-cysteine (NAC), an ROS scavenger, abrogated the effects of DHM on NF-kappaB-dependent autophagy.	ros	38-41	nuclear factor kappa B subunit 1	Homo sapiens	85-94
28482716-7	2017	Taken together, this evidence demonstrates that a strategy of blocking ROS-NF-kappaB-dependent autophagy to enhance the activity of DHM warrants further attention for the treatment of human melanoma.	ros	71-74	nuclear factor kappa B subunit 1	Homo sapiens	75-84
28249219-8	2017	Kidney dysfunction was paralleled by upregulation of ROS generating enzymes such as NOX2, NOX4 and iNOS with concomitant oxidative stress.	ros	53-56	nitric oxide synthase 2, inducible	Mus musculus	99-103
28052399-7	2017	In combination with Pb, a potent ROS inducer, CS2 could induce synergistic anti-cancer activity in HR/ BRCA1 defective breast cancer cells.	ros	33-36	chorionic somatomammotropin hormone 2	Homo sapiens	46-49
28316022-8	2017	Suppression of IMMP2L reduced the cell viability, increased the ROS production and decreased the mitochondrial membrane potential.	ros	64-67	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	Mus musculus	15-21
28426124-3	2017	In the present study, enhanced expression of HIF-1alpha accompanied by an increased ROS level was observed in lipopolysaccharide (LPS)-stimulated non-small cell lung cancer (NSCLC) cells.	ros	84-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	45-55
28411855-4	2017	AFM-SMFS results demonstrated that oridonin could inhibit the binding between EGF and EGFR in KYSE-150 cells by decreasing the unbinding force and binding probability for EGF-EGFR complexes, which was further proved to be closely associated with the intracellular ROS level.	ros	264-267	epidermal growth factor receptor	Homo sapiens	86-90
28411855-4	2017	AFM-SMFS results demonstrated that oridonin could inhibit the binding between EGF and EGFR in KYSE-150 cells by decreasing the unbinding force and binding probability for EGF-EGFR complexes, which was further proved to be closely associated with the intracellular ROS level.	ros	264-267	epidermal growth factor receptor	Homo sapiens	175-179
28411855-5	2017	More precise mechanism studies based on AFM-SMFS demonstrated that oridonin treatment could decrease the energy barrier width, increase the dissociation off rate constant and decrease the activation energy of EGF-EGFR complexes in ROS dependent way, suggesting oridonin as a strong anticancer agent targeting EGF-EGFR interactions in cancer cells through ROS dependent mechanism.	ros	231-234	epidermal growth factor receptor	Homo sapiens	213-217
28411855-5	2017	More precise mechanism studies based on AFM-SMFS demonstrated that oridonin treatment could decrease the energy barrier width, increase the dissociation off rate constant and decrease the activation energy of EGF-EGFR complexes in ROS dependent way, suggesting oridonin as a strong anticancer agent targeting EGF-EGFR interactions in cancer cells through ROS dependent mechanism.	ros	231-234	epidermal growth factor receptor	Homo sapiens	313-317
28411855-6	2017	Our results not only suggested oridonin as a strong anticancer agent targeting EGF-EGFR interactions in ROS dependent mechanism, but also highlighted AFM-SMFS as a powerful technique for pharmacodynamic studies by detecting ligand-receptor interactions, which was also expected to be developed into a promising tool for the screening and mechanism studies of drugs.	ros	104-107	epidermal growth factor receptor	Homo sapiens	83-87
28286271-5	2017	It was also clear that the increased ROS and the accumulation of lipid in BEL-7402 cells occurred when p16 expression was depleted with siRNA.	ros	37-40	cyclin dependent kinase inhibitor 2A	Homo sapiens	103-106
27021021-17	2017	SCOP can result in augmented ROS release in hippocampal neurons, leading to Ca2+ uptake through TRPM2 and TRPV1 channels.	ros	29-32	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	96-101
28030981-8	2017	The increased levels of MDA and decreased levels of GSH, SOD, catalase and TAC activity are strongly associated to ROS production and lipid peroxidation, suggesting the induction of oxidative stress in rats.	ros	115-118	catalase	Rattus norvegicus	62-70
28286271-6	2017	These findings indicate that p16 may play a critical role in the development of NASH by reining in ROS production and by inhabiting inflammatory response.	ros	99-102	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	29-32
28487634-12	2017	Based on our results, we propose that AbetaOs-induced Ca2+ entry and ROS generation jointly stimulate RyR2 activity, causing mitochondrial Ca2+ overload and fragmentation in a feed forward injurious cycle.	ros	69-72	ryanodine receptor 2	Homo sapiens	102-106
28407774-0	2017	ROS signaling under metabolic stress: cross-talk between AMPK and AKT pathway.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	66-69
28881620-5	2017	Importantly, the relative mechanisms were associated with reduced GRP78-Src interaction and ROS production, and subsequently reduced RhoA/ROCK activation, and eventually decreased VE-cadherin and myosin light chain (MLC) phosphorylation.	ros	92-95	heat shock protein 5	Mus musculus	66-71
28407774-8	2017	Here, we highlight the cross-talk between AMPK and AKT and their regulation on ROS production and elimination, which summarizes the mechanism of cancer cell adaptability under ROS stress and suggests potential options for cancer therapeutics.	ros	79-82	AKT serine/threonine kinase 1	Homo sapiens	51-54
28407774-8	2017	Here, we highlight the cross-talk between AMPK and AKT and their regulation on ROS production and elimination, which summarizes the mechanism of cancer cell adaptability under ROS stress and suggests potential options for cancer therapeutics.	ros	176-179	AKT serine/threonine kinase 1	Homo sapiens	51-54
28397855-4	2017	Here, a series of novel curcumin-BTP hybrids were designed and evaluated as STAT3 inhibitors with ROS production activity.	ros	98-101	signal transducer and activator of transcription 3	Homo sapiens	76-81
28417940-6	2017	The extract increased ROS production in HepG2 cells, which resulted in decreased GSH level, leading to apoptosis of these cells through activation of caspase-3 and caspase-7.	ros	22-25	caspase 3	Homo sapiens	150-159
27748761-0	2017	Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury.	ros	118-121	mitogen-activated protein kinase 1	Homo sapiens	32-35
28443293-1	2017	This article contains data related to the article "Wogonin, a plant derived small molecule exerts potent anti-inflammatory and chondroprotective effects through activation of ROS/ERK/Nrf2 signaling pathways in human Osteoarthritis chondrocytes" (Khan et al.	ros	175-178	mitogen-activated protein kinase 1	Homo sapiens	179-182
27748761-8	2017	We observed that HDACi induced ROS accumulation in cells and apoptosis via promotion of the CFL-1 interaction with Bax and CFL-1 translocation to the mitochondria, resulting in cytochrome C release.	ros	31-34	BCL2 associated X, apoptosis regulator	Homo sapiens	115-118
27748761-8	2017	We observed that HDACi induced ROS accumulation in cells and apoptosis via promotion of the CFL-1 interaction with Bax and CFL-1 translocation to the mitochondria, resulting in cytochrome C release.	ros	31-34	cytochrome c, somatic	Homo sapiens	177-189
28177770-8	2017	Using both pharmacological and molecular inhibitor approaches, we further identified that IL-6-mediated activation of NF-kappaB-iNOS-NO-ROS signaling in activated HSCs plays a critical role in BMOL-cell-mediated apoptosis of activated HSCs.	ros	136-139	interleukin 6	Mus musculus	90-94
28103509-7	2017	Collectively, our results suggest that DTMF stimulates ROS-mediated oxidative stress, which in turn induces PERK-CHOP and JNK pathway of apoptosis to promote HCT-116 cell death.	ros	55-58	DNA damage inducible transcript 3	Homo sapiens	113-117
28196676-0	2017	Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells.	ros	81-84	dihydroorotate dehydrogenase (quinone)	Homo sapiens	0-28
28196676-0	2017	Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells.	ros	81-84	dihydroorotate dehydrogenase (quinone)	Homo sapiens	30-35
28196676-6	2017	Here, we evaluated the effect of DHODH inhibitors on the production of ATP and ROS in sensitive and non-sensitive breast cancer cells.	ros	79-82	dihydroorotate dehydrogenase (quinone)	Homo sapiens	33-38
28196676-9	2017	DHODH inhibitors-sensitive T-47D and MDAMB-231 cells appeared to preserve ROS production closely to endogenous ROS level whereas the opposite was observed in non-sensitive MDAMB-436 and W3.006 cells.	ros	74-77	dihydroorotate dehydrogenase (quinone)	Homo sapiens	0-5
28196676-9	2017	DHODH inhibitors-sensitive T-47D and MDAMB-231 cells appeared to preserve ROS production closely to endogenous ROS level whereas the opposite was observed in non-sensitive MDAMB-436 and W3.006 cells.	ros	111-114	dihydroorotate dehydrogenase (quinone)	Homo sapiens	0-5
28110188-7	2017	The complex 1 and 2 treated cells show increased level of intracellular ROS generation which was preceded by p53 activation.	ros	72-75	tumor protein p53	Homo sapiens	109-112
28103509-7	2017	Collectively, our results suggest that DTMF stimulates ROS-mediated oxidative stress, which in turn induces PERK-CHOP and JNK pathway of apoptosis to promote HCT-116 cell death.	ros	55-58	mitogen-activated protein kinase 8	Homo sapiens	122-125
28202516-7	2017	This was due to higher ROS production and/or oncogene activation, such as RAS, MYC, and c-SRC.	ros	23-26	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	88-93
28122304-7	2017	In addition, flow cytometry results confirmed that treatment with a combination of IFN-lambda3 and sorafenib promotes the loss of mitochondrial membrane potential and induces the production of ROS more than treatment with either alone.	ros	193-196	interferon lambda 3	Homo sapiens	83-94
27441981-2	2017	Hemoglobin (Hb), myoglobin (Mb), neuroglobin (Ngb), and cytoglobin (Cygb) are globins with different distributions and functions in the tissues and have similar actions by providing O2 (oxygen) for respiratory chain, detoxification of ROS and nitric oxide (NO), and protect tissues against irreversible lesions.	ros	235-238	cytoglobin	Rattus norvegicus	68-72
28165467-14	2017	These results indicate that activating Nox2, Nox4, or Duox2 in pMMCs is essential for TGF-beta-mediated ROS generation.	ros	104-107	dual oxidase 2	Mus musculus	54-59
27880869-8	2017	The symbiotic microbiota is regulated largely by the Duox-ROS pathway in Drosophila.	ros	58-61	Dual oxidase	Drosophila melanogaster	53-57
27880869-9	2017	In mosquitoes, Duox-ROS pathway, heme-mediated signaling, antimicrobial peptide production and C-type lectins work in concert to maintain the dynamic microbial community in the midgut.	ros	20-23	Dual oxidase	Drosophila melanogaster	15-19
28242423-12	2017	The use of iNOS inhibitor LNMMA plus Ofloxacin or Chloramphenicol pretreatment enhanced bacterial clearance by increasing ROS.	ros	122-125	nitric oxide synthase 2, inducible	Mus musculus	11-15
28358377-7	2017	Knockdown of autophagy-related 5 (ATG5) inhibited the BAY-stimulated autophagosome formation, cellular ROS increase and cell death.	ros	103-106	autophagy related 5	Homo sapiens	13-32
27721403-5	2017	Subsequently, we demonstrated that CD45+CD33+CD11b+HLA-DR- MDSCs from fresh BC tissues displayed high levels of suppressive molecules, including Arg1, iNOS, ROS, PDL-1 and P-STAT3, and stronger suppression of T-cell proliferation.	ros	157-160	CD33 molecule	Homo sapiens	40-44
28063381-11	2017	In conclusion, these results indicated that the inhibition of Brd4 might protect against renal fibrosis by blocking the TGF-beta-Nox4-ROS-fibrosis axis, suggesting that Brd4 could be a promising therapeutic target.	ros	134-137	transforming growth factor, beta 1	Rattus norvegicus	120-128
28358377-7	2017	Knockdown of autophagy-related 5 (ATG5) inhibited the BAY-stimulated autophagosome formation, cellular ROS increase and cell death.	ros	103-106	autophagy related 5	Homo sapiens	34-38
28361889-8	2017	SUV39H augments intracellular ROS levels in a SIRT1-dependent manner.	ros	30-33	SUV39H1 histone lysine methyltransferase	Homo sapiens	0-6
28337975-3	2017	Here we show that the I4895T mutation in RyR1 decreases the amplitude of the sarcoplasmic reticulum (SR) Ca2+ transient, resting cytosolic Ca2+ levels, muscle triadin content and calsequestrin (CSQ) localization to the junctional SR, and increases endoplasmic reticulum (ER) stress/unfolded protein response (UPR) and mitochondrial ROS production.	ros	332-335	ryanodine receptor 1, skeletal muscle	Mus musculus	41-45
28350337-0	2017	3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFkappaB Signaling Pathways.	ros	147-150	AKT serine/threonine kinase 1	Homo sapiens	165-168
28350337-0	2017	3,4-Dihydroxybenzalactone Suppresses Human Non-Small Cell Lung Carcinoma Cells Metastasis via Suppression of Epithelial to Mesenchymal Transition, ROS-Mediated PI3K/AKT/MAPK/MMP and NFkappaB Signaling Pathways.	ros	147-150	nuclear factor kappa B subunit 1	Homo sapiens	182-190
28302174-13	2017	CONCLUSION: Our data demonstrate induction of a ROS/p38 MAPK -mediated feedback inhibitory pathway by oxy-cholesterol and steroid intermediates and products attenuates steroidogenesis via inhibition of CREB transcriptional activity.	ros	48-51	cAMP responsive element binding protein 1	Mus musculus	202-206
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	ros	49-52	mitogen-activated protein kinase kinase 7	Homo sapiens	217-220
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	ros	49-52	mitogen-activated protein kinase 1	Homo sapiens	221-224
28352661-9	2017	Consistent with increased oxidative stress, we found increased ROS production, decreased mitochondrial function, and abnormal mitochondrial morphology in ameloblasts of Stim1/2K14cre mice.	ros	63-66	stromal interaction molecule 1	Mus musculus	169-174
28302174-3	2017	Both the steroid products as well as major lipoprotein cholesterol donor, high-density lipoprotein 3 (hHDL3) have the potential to negatively regulate steroidogenesis via increased oxidative stress/reactive oxygen species (ROS) generation.	ros	223-226	HDL3	Homo sapiens	102-107
28302174-7	2017	Likewise, treatment of cells with pregnenolone, 22(R) diol or hHDL3 increased ROS production measured with the oxidation-sensitive fluorescent probe 2",7"-Dichlorofluorescin diacetate (DCFH-DA).	ros	78-81	HDL3	Homo sapiens	62-67
28257711-0	2017	DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization.	ros	47-50	IFN1@	Homo sapiens	78-83
28294157-0	2017	Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.	ros	98-101	alkaline ceramidase 2	Homo sapiens	0-21
28294157-0	2017	Alkaline ceramidase 2 is a novel direct target of p53 and induces autophagy and apoptosis through ROS generation.	ros	98-101	tumor protein p53	Homo sapiens	50-53
28294157-8	2017	Further studies clearly showed that ACER2-mediated autophagy and apoptosis are accompanied by ROS generation.	ros	94-97	alkaline ceramidase 2	Homo sapiens	36-41
28011320-8	2017	Both blocking of mitochondrial ROS and blocking the IL1 receptor stopped the promotion of fibrosis, inflammation and tumorigenesis resulting from Atg5 knockdown during the preneoplastic stage.	ros	31-34	autophagy related 5	Homo sapiens	146-150
28115750-10	2017	Nrf2 controls repair-associated inflammation and protects against excessive accumulation of ROS while Nf-kappaB activates the innate immune reaction, proliferation and migration of cells, modulates expression of matrix metalloproteinases, secretion and stability of cytokines and growth factors for wound healing.	ros	92-95	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
28003121-6	2017	Constitutive and transient Prx2 silencing in CRC cells increase ROS levels, and most importantly, enhance in vitro radiation sensitivity.	ros	64-67	peroxiredoxin 2	Homo sapiens	27-31
28035139-13	2017	Our findings uncover a novel mechanism through which mitochondrial PKM2 phosphorylates Bcl2 and inhibits apoptosis directly, highlight the essential role of PKM2 in ROS adaptation of cancer cells, and implicate HSP90-PKM2-Bcl2 axis as a potential target for therapeutic intervention in glioblastoma.	ros	165-168	BCL2 apoptosis regulator	Homo sapiens	87-91
28245605-0	2017	Tuberatolide B Suppresses Cancer Progression by Promoting ROS-Mediated Inhibition of STAT3 Signaling.	ros	58-61	signal transducer and activator of transcription 3	Homo sapiens	85-90
28167029-6	2017	Furthermore, the overexpression of BnNCED3 contributed to ABA accumulation and NO and ROS generation in transgenic Arabidopsis plants, thereby enhancing abiotic stress tolerance.	ros	86-89	9-cis-epoxycarotenoid dioxygenase NCED3, chloroplastic-like	Brassica napus	35-42
28092125-3	2017	RB/UCNP@ROS successfully inhibits Abeta self-assembly under NIR irradiation by generating 1 O2 .	ros	8-11	amyloid beta precursor protein	Homo sapiens	34-39
28092125-4	2017	Furthermore, photoexcited RB/UCNP@ROS is effective in suppressing Abeta-induced cytotoxicity.	ros	34-37	amyloid beta precursor protein	Homo sapiens	66-71
27817186-13	2017	Fluorescence intensity showed decreased activity of lysosomes and ROS in cells transfected with the antisense sequences of PDE4 A, B, C, and D.	ros	66-69	phosphodiesterase 4A	Homo sapiens	123-142
27995612-8	2017	IL-15 and IL-6 expression are stimulated by IFN-y and correlate with ROS levels in BM mononuclear cells.	ros	69-72	interleukin 6	Homo sapiens	10-14
28435452-3	2017	Mechanistically, increased KRAS expression induced ROS production, which elevated HIF-1alpha and YAP1 expression.	ros	51-54	hypoxia inducible factor 1 subunit alpha	Homo sapiens	82-92
28435452-4	2017	Increased HIF-1alpha persistently promoted DDX3 expression via a KRAS/ROS/HIF-1alpha feedback loop.	ros	70-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-20
28245605-8	2017	In addition, TTB-induced ROS generation caused STAT3 inhibition, DNA damage, and apoptotic cell death.	ros	25-28	signal transducer and activator of transcription 3	Homo sapiens	47-52
28245605-9	2017	Therefore, TTB suppresses cancer progression by promoting ROS-mediated inhibition of STAT3 signaling, suggesting that TTB is useful for the treatment of cancer.	ros	58-61	signal transducer and activator of transcription 3	Homo sapiens	85-90
32263872-7	2017	Furthermore, when PCP-Ru/uPA was at pH 5.3 with lysozyme, the release amount of RuPOP is the largest compared with pH at 5.3 or 7.4, and the release rate of RuPOP reached 75% at 48 h. In other words, the nanosystem with a pH-responsive effect swelled in an acidic environment and released free RuPOP in the lysosome of cancer cells efficiently, which triggered ROS up-regulation and induced apoptosis in MCF-7R cells.	ros	361-364	plasminogen activator, urokinase	Homo sapiens	25-28
28176763-2	2017	Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-beta-p38MAPK balances HSPC self-renewal and differentiation.	ros	57-60	transforming growth factor beta 1	Homo sapiens	61-69
28088327-8	2017	ROS levels were partially reduced by incubation with PP2 (c-Src inhibitor) or IL1RN, and further reduced by using the NOX1/4 inhibitor GKT137831.	ros	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	58-63
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	ros	131-134	interleukin 1 beta	Homo sapiens	6-14
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	ros	131-134	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	15-20
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	ros	131-134	interleukin 1 beta	Homo sapiens	25-33
28088327-9	2017	Thus, IL-1beta c-Src and IL-1beta NOX signaling pathways appear to be responsible for the production of cellular and mitochondrial ROS in CFTR-KD cells.	ros	131-134	CF transmembrane conductance regulator	Homo sapiens	138-142
28196147-0	2017	Correction: Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation.	ros	89-92	mitogen-activated protein kinase 14	Homo sapiens	26-29
28881609-5	2017	In combination, they affected the activation of Erk1/2 and counteracted the intrinsic and the extrinsic pathway of apoptosis, the DNA damage and the generation of ROS induced by oxaliplatin.	ros	163-166	mitogen-activated protein kinase 3	Homo sapiens	48-54
28120035-5	2017	Nrf2 knockdowns exhibited marked increases in mitochondrial membrane depolarization and ROS production following cisplatin treatment, with the cervical ME180R knockdowns exhibiting the greatest effect (AKR1C1 and AKR1C2 levels were decreased in the ME180R and SKOV3 cells to near zero).	ros	88-91	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
27810396-4	2017	Complex II-mediated ROS production exhibits a maximum at low (about 50muM) succinate concentration and gradually declines to zero activity upon further increase of the substrate.	ros	20-23	latexin	Homo sapiens	70-73
28065785-0	2017	A positive feedback loop between ROS and Mxi1-0 promotes hypoxia-induced VEGF expression in human hepatocellular carcinoma cells.	ros	33-36	vascular endothelial growth factor A	Homo sapiens	73-77
28065785-3	2017	In this study, we found that VEGF induction in hypoxic HepG2 cells is ROS-dependent.	ros	70-73	vascular endothelial growth factor A	Homo sapiens	29-33
28065785-4	2017	ROS mediates hypoxia-induced VEGF by upregulation of Mxi1-0.	ros	0-3	vascular endothelial growth factor A	Homo sapiens	29-33
28065785-4	2017	ROS mediates hypoxia-induced VEGF by upregulation of Mxi1-0.	ros	0-3	MAX interactor 1, dimerization protein	Homo sapiens	53-57
28065785-5	2017	Furthermore, PI3K/AKT/HIF-1alpha signaling pathway is involved in ROS-mediated Mxi1-0 and VEGF expression in hypoxic HepG2 cells.	ros	66-69	AKT serine/threonine kinase 1	Homo sapiens	18-21
27420645-0	2017	SIRT3 Silencing Sensitizes Breast Cancer Cells to Cytotoxic Treatments Through an Increment in ROS Production.	ros	95-98	sirtuin 3	Homo sapiens	0-5
28065785-5	2017	Furthermore, PI3K/AKT/HIF-1alpha signaling pathway is involved in ROS-mediated Mxi1-0 and VEGF expression in hypoxic HepG2 cells.	ros	66-69	hypoxia inducible factor 1 subunit alpha	Homo sapiens	22-32
28065785-5	2017	Furthermore, PI3K/AKT/HIF-1alpha signaling pathway is involved in ROS-mediated Mxi1-0 and VEGF expression in hypoxic HepG2 cells.	ros	66-69	MAX interactor 1, dimerization protein	Homo sapiens	79-83
28065785-5	2017	Furthermore, PI3K/AKT/HIF-1alpha signaling pathway is involved in ROS-mediated Mxi1-0 and VEGF expression in hypoxic HepG2 cells.	ros	66-69	vascular endothelial growth factor A	Homo sapiens	90-94
28065785-6	2017	Finally, Mxi1-0 could in turn regulate ROS generation in hypoxic HepG2 cells, creating a positive feedback loop.	ros	39-42	MAX interactor 1, dimerization protein	Homo sapiens	9-13
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	84-87	MAX interactor 1, dimerization protein	Homo sapiens	113-117
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	84-87	AKT serine/threonine kinase 1	Homo sapiens	143-146
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	84-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-157
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	84-87	vascular endothelial growth factor A	Homo sapiens	238-242
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	195-198	MAX interactor 1, dimerization protein	Homo sapiens	113-117
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	195-198	AKT serine/threonine kinase 1	Homo sapiens	143-146
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	195-198	hypoxia inducible factor 1 subunit alpha	Homo sapiens	147-157
28065785-7	2017	Taken together, this study demonstrate a positive regulatory feedback loop in which ROS mediates hypoxia-induced Mxi1-0 via activation of PI3K/AKT/HIF-1alpha pathway, events that in turn elevate ROS generation and promote hypoxia-induced VEGF expression.	ros	195-198	vascular endothelial growth factor A	Homo sapiens	238-242
27654302-7	2017	Meanwhile, fucoidan treatment increased the generation of intracellular ROS, whereas the over-elimination of ROS by N-acetylcysteine, an anti-oxidant, attenuated fucoidan-induced apoptosis, inhibition of hTERT, c-myc, and Sp1 expression, and reversed fucoidan-induced inactivation of the PI3K/Akt signaling pathway.	ros	109-112	AKT serine/threonine kinase 1	Homo sapiens	293-296
27654302-8	2017	Collectively, these data indicate that the induction of apoptosis and the inhibition of telomerase activity by fucoidan are mediated via ROS-dependent inactivation of the PI3K/Akt pathway.	ros	137-140	AKT serine/threonine kinase 1	Homo sapiens	176-179
28013460-0	2017	Arsenic trioxide induces ROS activity and DNA damage, leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway.	ros	25-28	ATR serine/threonine kinase	Homo sapiens	117-120
28287048-8	2017	These results showed that the antioxidant LBP could partially protect against UVB irradiation-induced photo-damage through activation of Nrf2/ARE pathway, thereby scavenging ROS and reducing DNA damage, and subsequently suppressing UVB-induced p38 MAP pathway.	ros	174-177	NFE2 like bZIP transcription factor 2	Homo sapiens	137-141
27420645-1	2017	SIRT3, the major deacetylase in mitochondria, plays a crucial role modulating ROS production and scavenging by regulating key proteins implicated in mitochondrial turnover and in antioxidant defenses.	ros	78-81	sirtuin 3	Homo sapiens	0-5
27420645-2	2017	Therefore, SIRT3 could confer resistance to chemotherapy-induced oxidative stress, leading to a lower ROS production and a higher cell survival.	ros	102-105	sirtuin 3	Homo sapiens	11-16
27420645-6	2017	When SIRT3 was silenced and combined with cytotoxic treatments, cell viability was highly decreased, and was accompanied by a significant increase in ROS production.	ros	150-153	sirtuin 3	Homo sapiens	5-10
27718123-12	2017	PPARgamma also enhanced the anti-oxidants molecules like Cu/Zn-SOD, Mn-SOD, and hemeoxygenase-1 by reducing the generation of ROS, even in the presence of H2O2.	ros	126-129	superoxide dismutase 1, soluble	Mus musculus	57-66
27718123-12	2017	PPARgamma also enhanced the anti-oxidants molecules like Cu/Zn-SOD, Mn-SOD, and hemeoxygenase-1 by reducing the generation of ROS, even in the presence of H2O2.	ros	126-129	superoxide dismutase 2, mitochondrial	Mus musculus	68-74
28011270-0	2017	H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation.	ros	91-94	angiotensinogen	Rattus norvegicus	13-27
27986568-1	2017	Deoxynyboquinone (DNQ), a potent novel quinone-based antineoplastic agent, selectively kills solid cancers with overexpressed cytosolic NAD(P)H:quinone oxidoreductase-1 (NQO1) via excessive ROS production.	ros	190-193	NAD(P)H quinone dehydrogenase 1	Homo sapiens	136-168
28139737-6	2017	These results establish a novel mechanism by which NF-kappaB and Akt contribute to chemoresistance involving a signaling pathway consisting of histone H4, DNA-PK, RIP1 and IAPs that attenuates ROS-mediated apoptosis, and targeting this pathway may improve the anticancer efficacy of platinum-based chemotherapy.	ros	193-196	AKT serine/threonine kinase 1	Homo sapiens	65-68
28139737-6	2017	These results establish a novel mechanism by which NF-kappaB and Akt contribute to chemoresistance involving a signaling pathway consisting of histone H4, DNA-PK, RIP1 and IAPs that attenuates ROS-mediated apoptosis, and targeting this pathway may improve the anticancer efficacy of platinum-based chemotherapy.	ros	193-196	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	155-161
28011270-0	2017	H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation.	ros	91-94	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	43-48
28011270-2	2017	A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibiting the NADPH oxidase 4 (Nox4)-ROS signaling in the heart.	ros	143-146	angiotensinogen	Rattus norvegicus	78-92
28011270-2	2017	A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibiting the NADPH oxidase 4 (Nox4)-ROS signaling in the heart.	ros	143-146	angiotensinogen	Rattus norvegicus	94-100
28011270-11	2017	In conclusion, our study indicates that H2S downregulates Ang II-induced atrial Kv1.5 expression by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2 activation during AF.	ros	125-128	angiotensinogen	Rattus norvegicus	58-64
28011270-11	2017	In conclusion, our study indicates that H2S downregulates Ang II-induced atrial Kv1.5 expression by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2 activation during AF.	ros	125-128	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	80-85
28011270-1	2017	Our previous study demonstrated that angiotensin II (Ang II) upregulates the expression of Kv1.5, a promising target for atrial fibrillation (AF) therapy, by activating ROS-dependent P-Smad2/3 and P-ERK 1/2.	ros	169-172	angiotensinogen	Rattus norvegicus	37-51
28011270-3	2017	The present study aimed to determine whether H2S is involved in the regulation of atrial Kv1.5 via ROS-related mechanisms in AF.	ros	99-102	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	89-94
28011270-1	2017	Our previous study demonstrated that angiotensin II (Ang II) upregulates the expression of Kv1.5, a promising target for atrial fibrillation (AF) therapy, by activating ROS-dependent P-Smad2/3 and P-ERK 1/2.	ros	169-172	angiotensinogen	Rattus norvegicus	53-59
28011270-7	2017	Sodium hydrosulfide (an exogenous H2S donor) and Nox4 siRNA inhibited Ang II-induced ROS production and Ang II-induced expression of Kv1.5, P-Smad2/3, P-ERK 1/2.	ros	85-88	angiotensinogen	Rattus norvegicus	70-76
28011270-1	2017	Our previous study demonstrated that angiotensin II (Ang II) upregulates the expression of Kv1.5, a promising target for atrial fibrillation (AF) therapy, by activating ROS-dependent P-Smad2/3 and P-ERK 1/2.	ros	169-172	potassium voltage-gated channel subfamily A member 5	Rattus norvegicus	91-96
28138562-7	2017	Mitochondrial oxidative phosphorylation is inappropriately enhanced and, as a result of impaired electron transport and mitochondrial ROS increase, caspase-3 is activated and DNA damage is induced.	ros	134-137	caspase 3	Homo sapiens	148-157
28009871-9	2017	Within the same concentration range, there was no cytotoxic effect of CP anthocyanins in CCD-18Co cells and TNF-alpha-induced intracellular ROS-production was decreased by 17.3%.	ros	140-143	tumor necrosis factor	Homo sapiens	108-117
27615282-8	2017	In parallel, ATL-1 stimulated TAM to produce NO by increasing the iNOS/arginase ratio and activated NADPH oxidase, triggering ROS production.	ros	126-129	atlastin GTPase 1	Homo sapiens	13-18
28102348-0	2017	HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2.	ros	89-92	heme oxygenase 1	Mus musculus	0-4
28102348-6	2017	Mechanistically, HO-1 reduces HFD-induced AKT2 phosphorylation via ROS thresholding in mitochondria to reduce visceral adipose precursor proliferation.	ros	67-70	heme oxygenase 1	Mus musculus	17-21
28102348-9	2017	This collectively renders HO-1 as an essential factor linking extrinsic factors (HFD) with inhibition of specific downstream molecular mediators (ROS &amp;AKT2), resulting in diminished adipogenesis that may contribute to hyperplastic adipose tissue expansion.	ros	146-149	heme oxygenase 1	Mus musculus	26-30
28086938-10	2017	Binding of uPAR to VN triggers integrin-mediated signals, which result in ERK1-2 and RAC activation, accumulation of ROS, and senescence.	ros	117-120	plasminogen activator, urokinase receptor	Mus musculus	11-15
28011195-3	2017	In this study, using direct co-culture model with LPS-activated and Dox-induced senescent THP-1 monocytes, we reported for the first time ROS-induced DNA damage, reduced metabolic activity, proliferation inhibition and cell cycle arrest followed by p16-, p21- and p27-mediated DNA damage response pathways activation, premature senescence and apoptosis induction in HeLa cells.	ros	138-141	GLI family zinc finger 2	Homo sapiens	90-95
28011195-3	2017	In this study, using direct co-culture model with LPS-activated and Dox-induced senescent THP-1 monocytes, we reported for the first time ROS-induced DNA damage, reduced metabolic activity, proliferation inhibition and cell cycle arrest followed by p16-, p21- and p27-mediated DNA damage response pathways activation, premature senescence and apoptosis induction in HeLa cells.	ros	138-141	cyclin dependent kinase inhibitor 2A	Homo sapiens	249-252
28011195-3	2017	In this study, using direct co-culture model with LPS-activated and Dox-induced senescent THP-1 monocytes, we reported for the first time ROS-induced DNA damage, reduced metabolic activity, proliferation inhibition and cell cycle arrest followed by p16-, p21- and p27-mediated DNA damage response pathways activation, premature senescence and apoptosis induction in HeLa cells.	ros	138-141	zinc ribbon domain containing 2	Homo sapiens	264-267
28086938-11	2017	In shENO1 cancer cells, the use of an anti-uPAR antibody caused significant reduction of ROS production and senescence.	ros	89-92	plasminogen activator, urokinase receptor	Mus musculus	43-47
27926485-3	2017	Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment.	ros	85-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	24-27
28079897-6	2017	Indeed, Tsc1 promotes DC survival through restraining independent mTORC1 and ROS-Bim pathways.	ros	77-80	TSC complex subunit 1	Homo sapiens	8-12
27926485-3	2017	Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment.	ros	85-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	28-32
27926485-3	2017	Moreover, we found that p21(Waf1/Cip1) increased levels correlates with induction of ROS and senescence-associated cell death in U87 and T98 cell lines, which are reverted by N-acetyl cysteine pretreatment.	ros	85-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	33-37
27936335-8	2017	Increased phosphorylation of P38 MAPK in G0 cells also increased cellular radioresistance; however, excessive production of ROS caused P38 MAPK dephosphorylation.	ros	124-127	mitogen-activated protein kinase 14	Homo sapiens	29-32
27888812-5	2017	SLNT induced apoptosis by activating Caspase-3 via both intrinsic and extrinsic pathways, which presented as the activation of Caspases-9 and -8, upregulation of cytochrome c and the Bax/Bcl-2 ratio, downregulation of NF-kappaB, and overproduction of ROS and TNF-alpha in vitro and in vivo.	ros	251-254	caspase 3	Homo sapiens	37-46
27936335-8	2017	Increased phosphorylation of P38 MAPK in G0 cells also increased cellular radioresistance; however, excessive production of ROS caused P38 MAPK dephosphorylation.	ros	124-127	mitogen-activated protein kinase 14	Homo sapiens	135-138
28662515-9	2017	CONCLUSIONS: Our results revealed that shikonin could inhibit cells viability and induce apoptosis of CCA cells, effects enhanced by TRAIL treatment via ROS mediated JNK signalling pathways, involving up-regulation of DR5 expression.	ros	153-156	TNF superfamily member 10	Homo sapiens	133-138
28567457-0	2017	SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death.	ros	11-14	sirtuin 3	Homo sapiens	0-5
28567457-12	2017	Overexpression of SIRT3 significantly inhibited linalool-induced increase of mitochondrial ROS production and apoptotic cell death, and decrease of cell viability.	ros	91-94	sirtuin 3	Homo sapiens	18-23
28567457-13	2017	In summary, the data demonstrated that linalool exhibited inhibitory effect on glioma cells through regulation of SIRT3-SOD2-ROS signaling.	ros	125-128	sirtuin 3	Homo sapiens	114-119
27899257-11	2017	In addition, the ROS scavenger also inhibited G2/M phase arrest and phosphorylated JNK.	ros	17-20	mitogen-activated protein kinase 8	Homo sapiens	83-86
27729002-12	2017	In conclusion, we identified that miR-30 functioned as a potential oncomiR through P53/ROS-mediated regulation of mitochondrial apoptotic pathway.	ros	87-90	tumor protein p53	Homo sapiens	83-86
28662515-7	2017	Furhermore, TRAIL enhanced anti-proliferation of shikonin and shikonin induced apoptosis through induction of ROS mediated JNK activation, while AKT activation had an effect on shikonin anti-proliferation activity, but not in the TRAIL enhanced counterparts.	ros	110-113	TNF superfamily member 10	Homo sapiens	12-17
28693022-10	2017	Exposure of platelets to CRP was followed by significant increase of [Ca2+]i, P-selectin abundance, alphaIIbbeta3 integrin activity, annexin-V-binding, ROS, caspase activity and aggregation, effects significantly blunted in the presence of temsirolimus.	ros	152-155	C-reactive protein	Homo sapiens	25-28
28662515-7	2017	Furhermore, TRAIL enhanced anti-proliferation of shikonin and shikonin induced apoptosis through induction of ROS mediated JNK activation, while AKT activation had an effect on shikonin anti-proliferation activity, but not in the TRAIL enhanced counterparts.	ros	110-113	mitogen-activated protein kinase 8	Homo sapiens	123-126
28662515-9	2017	CONCLUSIONS: Our results revealed that shikonin could inhibit cells viability and induce apoptosis of CCA cells, effects enhanced by TRAIL treatment via ROS mediated JNK signalling pathways, involving up-regulation of DR5 expression.	ros	153-156	mitogen-activated protein kinase 8	Homo sapiens	166-169
28854431-10	2017	In NRK-52E cells, iopromide caused enhanced apoptotic rates and ROS generation, which could be ameliorated by inhibitor of TLR4 and NLRP3-siRNA.	ros	64-67	NLR family, pyrin domain containing 3	Rattus norvegicus	132-137
29179175-10	2017	HPC with siRNA targeting Cx43 or the ROS scavengers SOD plus CAT significantly prevented ROS generation and HPC cardioprotection, but HPC with either SOD or CAT did not.	ros	37-40	catalase	Rattus norvegicus	61-64
29179175-10	2017	HPC with siRNA targeting Cx43 or the ROS scavengers SOD plus CAT significantly prevented ROS generation and HPC cardioprotection, but HPC with either SOD or CAT did not.	ros	89-92	gap junction protein, alpha 1	Rattus norvegicus	25-29
29179175-10	2017	HPC with siRNA targeting Cx43 or the ROS scavengers SOD plus CAT significantly prevented ROS generation and HPC cardioprotection, but HPC with either SOD or CAT did not.	ros	89-92	catalase	Rattus norvegicus	61-64
29179175-11	2017	These data strongly supported the involvement of Cx43 in HPC cardioprotection, likely via modulation of the ROS balance which plays a central role in HPC protection.	ros	108-111	gap junction protein, alpha 1	Rattus norvegicus	49-53
29179175-13	2017	CONCLUSION: Mitochondrial HSP90 played a central role in HPC cardioprotection, and its activity was linked to the mitochondrial targeting of Cx43, the activation of which triggered ROS signaling and the subsequent reduction of redox stress.	ros	181-184	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	26-31
29179175-13	2017	CONCLUSION: Mitochondrial HSP90 played a central role in HPC cardioprotection, and its activity was linked to the mitochondrial targeting of Cx43, the activation of which triggered ROS signaling and the subsequent reduction of redox stress.	ros	181-184	gap junction protein, alpha 1	Rattus norvegicus	141-145
26631910-5	2017	IFNgamma induced mitochondrial co-localization of RIG-I was concomitant with its ability to regulate ROS generation, oxidative phosphorylation (OXPHOS) and key enzymes involved in glycolysis and pentose phosphate pathway.	ros	101-104	interferon gamma	Homo sapiens	0-8
26916392-7	2017	In addition, several BPs at 10-50 muM resulted in a significantly concentration-depended increase in DNA-damaging effect on MCF-7 cells and elevated ROS production.	ros	149-152	latexin	Homo sapiens	34-37
28883885-7	2017	Moreover, sequential activation of ROS-dependent phosphor-Akt expression was dose-dependently inhibited by the combinational application of BA and Ptx, which was more significantly effective than the single treatment of either BA or Ptx.	ros	35-38	AKT serine/threonine kinase 1	Homo sapiens	58-61
27913286-6	2017	Coumestrol treatment induced ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation.	ros	29-32	tumor protein p53	Homo sapiens	91-94
27913286-10	2017	In conclusion, copper targeted ROS-mediated p53-dependent mechanism better explains the cytotoxic action of coumestrol in MCF-7 cells.	ros	31-34	tumor protein p53	Homo sapiens	44-47
27771381-4	2017	Niacin, NAM and 2-Pyr significantly decreased ROS, NO and NOS2 expression in LPS-treated human mature macrophages.	ros	46-49	SH3 and cysteine rich domain 3	Homo sapiens	8-11
28592114-10	2017	However, pretreatment with N-acetyl- L-cysteine (NAC), a ROS scavenger, increased the expression of procaspase-3.	ros	57-60	caspase 3	Homo sapiens	100-112
26764232-10	2017	Silencing of Kv1.5 with siRNA reduced palmitate-induced endothelial apoptosis, intracellular ROS generation, mitochondrial ROS generation and membrane potential (Deltapsim) alteration and cleaved caspase-3 protein expression; while increased cell viability and ratio of Bcl-2/Bax.	ros	93-96	potassium voltage-gated channel, shaker-related subfamily, member 5	Mus musculus	13-18
26764232-10	2017	Silencing of Kv1.5 with siRNA reduced palmitate-induced endothelial apoptosis, intracellular ROS generation, mitochondrial ROS generation and membrane potential (Deltapsim) alteration and cleaved caspase-3 protein expression; while increased cell viability and ratio of Bcl-2/Bax.	ros	123-126	potassium voltage-gated channel, shaker-related subfamily, member 5	Mus musculus	13-18
26764232-13	2017	SIGNIFICANCE: These results demonstrate that suppression of Kv1.5 protects endothelial cells against palmitate-induced apoptosis via inhibiting mitochondria-mediated excessive ROS generation and apoptotic signaling pathway, suggesting that Kv1.5 may serve as a therapeutic target of treatment for endothelial dysfunction induced by palmitate and lipid metabolism in T2DM patients.	ros	176-179	potassium voltage-gated channel subfamily A member 5	Homo sapiens	60-65
28717410-0	2017	Fish Scale Collagen Peptides Protect against CoCl2/TNF-alpha-Induced Cytotoxicity and Inflammation via Inhibition of ROS, MAPK, and NF-kappaB Pathways in HaCaT Cells.	ros	117-120	tumor necrosis factor	Homo sapiens	51-60
29098061-4	2017	Furthermore, under in vitro conditions, BNF treatment induced cellular ROS production, which was inhibited by mitochondria-targeted antioxidant Mito-CP and CYP inhibitor proadefin, suggesting that most of the ROS production was intramitochondrial and probably involved the catalytic activity of mitochondrial CYP1 enzymes.	ros	71-74	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	309-313
28694915-6	2017	Overall, our study is the first to demonstrate that the cytoprotective actions of halophenols involve their antiapoptotic, antioxidant, and anti-inflammatory abilities, which are mediated by the upregulation of Nrf2-dependent HO-1 expression and reductions in ROS and TNF-alpha generation via the activation of Erk1/2 and PI3K/Akt in EA.hy926 cells.	ros	260-263	NFE2 like bZIP transcription factor 2	Homo sapiens	211-215
29109834-6	2017	Nrf2 overexpression significantly alleviated mechanical injury-induced ROS accumulation and oxidative damage; in contrast, Nrf2 silencing exhibited opposite effects.	ros	71-74	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
29410730-8	2017	Pharmacological or genetic inhibition of NRF2 and/or treatment with lapatinib or erlotinib elevated cellular ROS and depleted glutathione.	ros	109-112	NFE2 like bZIP transcription factor 2	Homo sapiens	41-45
27856279-0	2016	The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells.	ros	4-7	signal transducer and activator of transcription 3	Homo sapiens	31-37
27864022-9	2017	NAC, an inhibitor of ROS, completely blocked apoptosis, caspase and PARP activation induced by Shikonin.	ros	21-24	poly(ADP-ribose) polymerase 1	Homo sapiens	68-72
27864022-11	2017	The enhancement of ROS generation in H1650 and H1975 gefitinib-resistant NSCLC cells leads to impairment of growth and induction of apoptosis, whereas modulation of EGFR degradation and its downstream signalling pathways by Shikonin contributes to its anti-tumour properties in H1975 gefitinib-resistant NSCLC cells (with T790M and L858R activating mutations).	ros	19-22	epidermal growth factor receptor	Homo sapiens	165-169
27463837-8	2017	Sesn2 ablation increased UVA-induced Nrf2 induction and inhibits UVA-induced ROS production, indicating that Sesn2 acts as an upstream regulator of Nrf2.	ros	77-80	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
27993686-7	2017	Overexpression of miR-126 could decrease the expression of downstream components of HMGB1 including TNF-alpha, ROS, and NADPH oxidase activity in HUVECs under hyperglycemic condition.	ros	111-114	microRNA 126a	Mus musculus	18-25
27993686-12	2017	In summary, our findings suggest that miR-126 may suppress inflammation and ROS production in endothelial cells treated by high glucose through modulating the expression of HMGB1.	ros	76-79	microRNA 126a	Mus musculus	38-45
28004759-9	2016	LR12 also reduced the expression of NLRP3 and caspase-1 p10 protein, and secretion of the IL-1beta, inhibited activation of the NLRP3 inflammasome by decreasing ROS.	ros	161-164	interleukin 1 beta	Mus musculus	90-98
27798104-5	2016	These cytokines are dependent on p38 activation, which is increased in the absence of kindlin-1 and induced by higher ROS levels.	ros	118-121	mitogen-activated protein kinase 14	Homo sapiens	33-36
27977690-8	2016	Interestingly, Ex-4 significantly reduced Ang II and TGF-beta1 production by inhibition of ROS production but not ERK phosphorylation.	ros	91-94	transforming growth factor beta 1	Homo sapiens	53-62
27856279-0	2016	The ROS-mediated activation of STAT-3/VEGF signaling is involved in the 27-hydroxycholesterol-induced angiogenesis in human breast cancer cells.	ros	4-7	vascular endothelial growth factor A	Homo sapiens	38-42
27856279-4	2016	For the molecular mechanisms, on one hand, as an estrogen-like factor, 27HC enhanced the expression of VEGF by the classical ERalpha/VEGF signaling in ER-positive BC cells; on the other hand, in both ER-positive and ER-negative BC cells, 27HC enhanced the generation of ROS, which in turn activated the STAT-3/VEGF signaling in an ER independent manner.	ros	270-273	vascular endothelial growth factor A	Homo sapiens	103-107
27856279-5	2016	Either blocking the generation of ROS or knockdown of STAT-3 attenuated the 27HC-induced autocrine of VEGF and angiogenesis.	ros	34-37	vascular endothelial growth factor A	Homo sapiens	102-106
27924932-12	2016	Overexpression of a constitutively active form of NRF2 (caNRF2) in NOX4 depleted cells rescued most of this phenotype in cultured cells, implying that NRF2 regulation by ROS issued from NOX4 may play an important role in its anti-apoptotic property.	ros	170-173	nuclear factor, erythroid derived 2, like 2	Mus musculus	50-54
27934866-5	2016	Complementation of the yeast yap1 mutant with CaTLP1 revealed its role in ROS scavenging.	ros	74-77	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	29-33
27924932-12	2016	Overexpression of a constitutively active form of NRF2 (caNRF2) in NOX4 depleted cells rescued most of this phenotype in cultured cells, implying that NRF2 regulation by ROS issued from NOX4 may play an important role in its anti-apoptotic property.	ros	170-173	nuclear factor, erythroid derived 2, like 2	Mus musculus	58-62
27926860-5	2016	Moreover, GLR3.1/3.5 Ca2+ channels are distinct from previously characterized ROS-activated Ca2+ channels and act upstream of ROS, providing Ca2+ transients necessary for the activation of NADPH oxidases.	ros	78-81	glutamate receptor 2	Arabidopsis thaliana	10-16
27926860-5	2016	Moreover, GLR3.1/3.5 Ca2+ channels are distinct from previously characterized ROS-activated Ca2+ channels and act upstream of ROS, providing Ca2+ transients necessary for the activation of NADPH oxidases.	ros	126-129	glutamate receptor 2	Arabidopsis thaliana	10-16
27926860-6	2016	Our data indicate that GLR3.1/3.5 constitute L-Met-activated Ca2+ channels responsible for maintaining basal [Ca2+]cyt, play a pivotal role in plant growth, and act upstream of ROS, thereby regulating stomatal aperture.	ros	177-180	glutamate receptor 2	Arabidopsis thaliana	23-31
27789709-2	2016	PRC induction by mitochondrial inhibitors, intracellular ROS, or topoisomerase I inhibition orchestrates an inflammatory program associated with the adaptation to cellular stress.	ros	57-60	PPARG related coactivator 1	Homo sapiens	0-3
27741521-2	2016	Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1).	ros	64-67	poly(ADP-ribose) polymerase 1	Homo sapiens	168-197
27741521-2	2016	Our recent work suggests that reactive oxygen/nitrogen species (ROS/RNS) induced by arsenite (AsIII) play an important role in the inhibition of the DNA repair protein Poly(ADP-ribose) polymerase 1 (PARP-1).	ros	64-67	poly(ADP-ribose) polymerase 1	Homo sapiens	199-205
27741521-3	2016	AsIII-induced ROS lead to oxidation of cysteine residues within the PARP-1 zinc finger DNA binding domain.	ros	14-17	poly(ADP-ribose) polymerase 1	Homo sapiens	68-74
27793052-0	2016	Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-kappaB signaling and NLRP3 inflammasome activation.	ros	75-78	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
27793052-5	2016	Finally, we confirmed that ROS scavenging was responsible for Andrographolide"s inactivation of NF-kappaB and NLRP3 inflammasome signaling.	ros	27-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
27694907-14	2016	CONCLUSION: Physcion induces apoptosis and autophagy in human nasopharyngeal carcinoma by targeting Sp1, which was mediated by ROS/miR-27a/ZBTB10 signaling.	ros	127-130	microRNA 27a	Homo sapiens	131-138
26472167-7	2016	Furthermore, ROS generation and subsequent activation of JNK and ERK might be involved in PM2.5 -induced apoptosis and G0/G1 phase arrest by downregulating Bcl-2/Bax protein ratio and upregulating p15INK4B , p16INK4A , and p21WAF1/CIP1 transcription level.	ros	13-16	mitogen-activated protein kinase 1	Homo sapiens	65-68
27376435-0	2016	Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.	ros	26-29	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	104-109
27376435-5	2016	Using FRET-based live cell imaging, together with pharmacological inhibitors and lentiviral-mediated shRNA knockdown, we demonstrate that MPH promoted ROS generation via activation of Rac1-dependent NADPH oxidase (NOX) and c-Src activation at the plasma membrane.	ros	151-154	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	223-228
28066829-5	2016	Reduced glutathione, the principal small molecule antioxidant in the mammalian cell and a product of several of the downstream target genes of Nrf2, counterbalances mitochondrial ROS production.	ros	179-182	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
26472167-7	2016	Furthermore, ROS generation and subsequent activation of JNK and ERK might be involved in PM2.5 -induced apoptosis and G0/G1 phase arrest by downregulating Bcl-2/Bax protein ratio and upregulating p15INK4B , p16INK4A , and p21WAF1/CIP1 transcription level.	ros	13-16	BCL2 apoptosis regulator	Homo sapiens	156-161
26472167-7	2016	Furthermore, ROS generation and subsequent activation of JNK and ERK might be involved in PM2.5 -induced apoptosis and G0/G1 phase arrest by downregulating Bcl-2/Bax protein ratio and upregulating p15INK4B , p16INK4A , and p21WAF1/CIP1 transcription level.	ros	13-16	BCL2 associated X, apoptosis regulator	Homo sapiens	162-165
26472167-7	2016	Furthermore, ROS generation and subsequent activation of JNK and ERK might be involved in PM2.5 -induced apoptosis and G0/G1 phase arrest by downregulating Bcl-2/Bax protein ratio and upregulating p15INK4B , p16INK4A , and p21WAF1/CIP1 transcription level.	ros	13-16	cyclin dependent kinase inhibitor 2B	Homo sapiens	197-205
27816841-5	2016	In this process, ROS dominates the antioxidants factors such as GPx, GS, GSH, MT-III, Catalase, SOD, BDNF, and CERB, and finally leads to cognitive dysfunction.	ros	17-20	catalase	Homo sapiens	86-94
26472167-7	2016	Furthermore, ROS generation and subsequent activation of JNK and ERK might be involved in PM2.5 -induced apoptosis and G0/G1 phase arrest by downregulating Bcl-2/Bax protein ratio and upregulating p15INK4B , p16INK4A , and p21WAF1/CIP1 transcription level.	ros	13-16	cyclin dependent kinase inhibitor 2A	Homo sapiens	208-216
27816841-5	2016	In this process, ROS dominates the antioxidants factors such as GPx, GS, GSH, MT-III, Catalase, SOD, BDNF, and CERB, and finally leads to cognitive dysfunction.	ros	17-20	superoxide dismutase 1	Homo sapiens	96-99
26472167-7	2016	Furthermore, ROS generation and subsequent activation of JNK and ERK might be involved in PM2.5 -induced apoptosis and G0/G1 phase arrest by downregulating Bcl-2/Bax protein ratio and upregulating p15INK4B , p16INK4A , and p21WAF1/CIP1 transcription level.	ros	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	231-235
26472167-8	2016	In conclusion, our results indicate that ROS-JNK/ERK-apoptosis and G0/G1 arrest pathways are involved in PM2.5 -induced embryotoxicity, which not only provides insights into the molecular mechanism of PM2.5 -induced embryotoxicity, but also may help to identify specific interventions to improve adverse pregnancy outcomes of PM2.5 .	ros	41-44	mitogen-activated protein kinase 8	Homo sapiens	45-48
26472167-8	2016	In conclusion, our results indicate that ROS-JNK/ERK-apoptosis and G0/G1 arrest pathways are involved in PM2.5 -induced embryotoxicity, which not only provides insights into the molecular mechanism of PM2.5 -induced embryotoxicity, but also may help to identify specific interventions to improve adverse pregnancy outcomes of PM2.5 .	ros	41-44	mitogen-activated protein kinase 1	Homo sapiens	49-52
27825816-0	2016	Corrigendum to "Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway" [Free Radic.	ros	113-116	AKT serine/threonine kinase 1	Homo sapiens	133-136
27746262-10	2016	The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma.	ros	164-167	AKT serine/threonine kinase 1	Homo sapiens	23-26
27746262-10	2016	The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma.	ros	164-167	AKT serine/threonine kinase 1	Homo sapiens	173-176
27746262-0	2016	Caffeic acid phenethyl ester alleviates asthma by regulating the airway microenvironment via the ROS-responsive MAPK/Akt pathway.	ros	97-100	AKT serine/threonine kinase 1	Homo sapiens	117-120
27746262-10	2016	The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma.	ros	91-94	AKT serine/threonine kinase 1	Homo sapiens	23-26
27746262-10	2016	The phosphorylation of Akt and Mitogen-Activated Protein Kinase (MAPK) caused by increased ROS was significantly decreased by CAPE, which implied a contribution of ROS-MAPK/Akt signaling to the attenuation of asthma.	ros	91-94	AKT serine/threonine kinase 1	Homo sapiens	173-176
26672612-3	2016	Serial passaging from P1 to P4 (replicative senescence) and treatment of P1 endothelial cells with the eNOS inhibitor L-NAME (premature senescence) promoted acquisition of markers of senescence, enhanced ROS formation, decreased eNOS expression, and upregulation of angiotensin-converting enzyme (ACE) and AT1 receptors.	ros	204-207	nitric oxide synthase 3	Homo sapiens	103-107
27640015-8	2016	Molecular docking revealed the mechanistic binding of Ganoderic acid A in STAT3 signaling, which inhibits the proliferation, viability, and ROS in PC-3 cells.	ros	140-143	signal transducer and activator of transcription 3	Homo sapiens	74-79
29372968-4	2016	The AuNPs reduced TNF-alpha-induced intracellular ROS production and NF-kappaB signaling pathways and enhanced CAM protein degradation by increasing their ubiquitination.	ros	50-53	tumor necrosis factor	Rattus norvegicus	18-27
27881174-3	2016	FAMIN, that is formerly also referred to as LACC1 or C13orf31, has recently been shown to play a crucial role in immune-metabolic functions and is involved in regulation of inflammasome activation and promotion of ROS production.	ros	214-217	laccase domain containing 1	Homo sapiens	0-5
26785383-4	2016	Data indicate that DDSD induced the generation of ROS, consequentially caused alteration in Bax/Bcl-2 ratio that disrupted the inner mitochondrial transmembrane potential (DeltaPsim) resulting in cytochrome c redistribution to the cytoplasm and activation of caspase-mediated apoptotic pathway.	ros	50-53	B cell leukemia/lymphoma 2	Mus musculus	96-101
27307186-5	2016	Intracellular reactive oxygen spices (ROS) induced by DIM (20 and 30 muM, 2 h before irradiation) was measured by flow cytometry.	ros	38-41	latexin	Homo sapiens	69-72
27632242-0	2016	The involvement of ROS producing aldehyde oxidase in plant response to Tombusvirus infection.	ros	19-22	aldehyde oxidase 1	Homo sapiens	33-49
27881174-3	2016	FAMIN, that is formerly also referred to as LACC1 or C13orf31, has recently been shown to play a crucial role in immune-metabolic functions and is involved in regulation of inflammasome activation and promotion of ROS production.	ros	214-217	laccase domain containing 1	Homo sapiens	44-49
27881174-3	2016	FAMIN, that is formerly also referred to as LACC1 or C13orf31, has recently been shown to play a crucial role in immune-metabolic functions and is involved in regulation of inflammasome activation and promotion of ROS production.	ros	214-217	laccase domain containing 1	Homo sapiens	53-61
27874067-8	2016	Our results provided the first evidence that 5-HTR as a GPCR and an ion channel, functionally expressed in mitochondria and participated in the mitochondria function and regulation to maintain homeostasis of mitochondrial [Ca2+], ROS, and ATP generation efficiency in cardiomyocytes in response to stress and O2 tension.	ros	230-233	telomerase RNA component	Homo sapiens	47-50
27876813-0	2016	Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism.	ros	94-97	signal transducer and activator of transcription 3	Homo sapiens	122-127
27904667-9	2016	Additionally, our findings revealed that icaritin exerted anti-tumor effect by modulating Stat3 through generating ROS and subsequent activation of AMPK and inhibition of mTOR.	ros	115-118	signal transducer and activator of transcription 3	Homo sapiens	90-95
27773814-3	2016	Sirtuin3(Sirt3), a kind of mitochondria-localized nicotinamide adenine dinucleotide(NAD+)-dependent protein deacetylase, has been reported to regulate the generation of ROS in mitochondria through regulating acetylation level and activity of several key mitochondrial enzymes.	ros	169-172	sirtuin 3	Homo sapiens	0-8
27773814-3	2016	Sirtuin3(Sirt3), a kind of mitochondria-localized nicotinamide adenine dinucleotide(NAD+)-dependent protein deacetylase, has been reported to regulate the generation of ROS in mitochondria through regulating acetylation level and activity of several key mitochondrial enzymes.	ros	169-172	sirtuin 3	Homo sapiens	9-14
27773814-8	2016	In conclusion, our data suggest that Sirt3 overexpression antagonize high glucose-induced apoptosis by controlling ROS accumulation and ROS-sensitive Akt/FoxO signaling pathway in HK-2 cells.	ros	115-118	sirtuin 3	Homo sapiens	37-42
27773814-8	2016	In conclusion, our data suggest that Sirt3 overexpression antagonize high glucose-induced apoptosis by controlling ROS accumulation and ROS-sensitive Akt/FoxO signaling pathway in HK-2 cells.	ros	136-139	sirtuin 3	Homo sapiens	37-42
27773814-8	2016	In conclusion, our data suggest that Sirt3 overexpression antagonize high glucose-induced apoptosis by controlling ROS accumulation and ROS-sensitive Akt/FoxO signaling pathway in HK-2 cells.	ros	136-139	AKT serine/threonine kinase 1	Homo sapiens	150-153
27647936-3	2016	H2O2-stimulated ROS production was markedly increased in yeast expressing K13R hPDE3A (Oxidative stress Sensitive 1, OxiS1), compared with yeast expressing WT hPDE3A (Oxidative stress Resistant 1, OxiR1).	ros	16-19	phosphodiesterase 3A	Homo sapiens	79-85
27634749-14	2016	RESULTS: Under renal fibrosis conditions, TGF-beta1 (5ng/ml) increased ROS.	ros	71-74	transforming growth factor, beta 1	Rattus norvegicus	42-51
27038042-7	2016	We found evidence that the specific engagement of CEACAM3 by M. catarrhalis ubiquitous surface protein A1 (UspA1) results in the activation of pro-inflammatory events, such as degranulation of neutrophils, ROS production and chemokine secretion.	ros	206-209	CEA cell adhesion molecule 3	Homo sapiens	50-57
27895577-5	2016	Fus1 KO mice showed oxidative stress (increased levels of ROS, decreased levels of PRDX1), disruption of metabolic homeostasis (decreased levels of ACC2, increased phosphorylation of AMPK), autophagy (decreased levels of LC3-II), PKC (decreased levels of RACK1) and calcium signaling (decreased levels of Calb2) in the olfactory bulb and/or hippocampus.	ros	58-61	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	0-4
27740938-9	2016	7-KC further induced intracellular ROS production as shown by increase in DCF fluorescence and Akt phosphorylation.	ros	35-38	AKT serine/threonine kinase 1	Homo sapiens	95-98
27659528-0	2016	Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway.	ros	106-109	AKT serine/threonine kinase 1	Homo sapiens	147-150
27620662-18	2016	CONCLUSIONS: Nrf2, an EC protective system, suppresses monocyte adhesion events via the inhibition of the ROS - TNF-alpha - p38 - VCAM-1 pathway following treatment with PNS, with Rb1 specifically playing an important role among PNS active components.	ros	106-109	tumor necrosis factor	Rattus norvegicus	112-121
27620662-18	2016	CONCLUSIONS: Nrf2, an EC protective system, suppresses monocyte adhesion events via the inhibition of the ROS - TNF-alpha - p38 - VCAM-1 pathway following treatment with PNS, with Rb1 specifically playing an important role among PNS active components.	ros	106-109	mitogen-activated protein kinase 14	Homo sapiens	124-127
27620662-18	2016	CONCLUSIONS: Nrf2, an EC protective system, suppresses monocyte adhesion events via the inhibition of the ROS - TNF-alpha - p38 - VCAM-1 pathway following treatment with PNS, with Rb1 specifically playing an important role among PNS active components.	ros	106-109	vascular cell adhesion molecule 1	Homo sapiens	130-136
27782264-7	2016	Phase 2 enzymes in term of antioxidant response, such as heme oxygenase 1 (HMOX1) and the regulating subunit of the glutamate-cysteine ligase (GCLM) were slightly upregulated, but these observations may be linked solely to metal homeostasis disruptions, as these actors are involved in both metal and ROS responses.	ros	301-304	glutamate-cysteine ligase modifier subunit	Homo sapiens	143-147
27806094-10	2016	Furthermore, a significant decrease in pAKT, pERK and p-p38 was shown following the addition of the ROS inhibitor NAC.	ros	100-103	mitogen-activated protein kinase 14	Homo sapiens	56-59
27599716-8	2016	ROS generation and mitochondrial dysfunction by Abeta were attenuated when treated with Mdivi-1, a selective Drp1 inhibitor.	ros	0-3	amyloid beta precursor protein	Homo sapiens	48-53
27599716-10	2016	Inhibition of autophagic clearance of Abeta led to increased ROS levels and aggravating mitochondrial defects, which were blocked by Rapamycin (an mTOR inhibitor).	ros	61-64	amyloid beta precursor protein	Homo sapiens	38-43
27575019-5	2016	In Atg3 null mouse ESCs, accumulation of aberrant mitochondria was accompanied by enhanced ROS generation, defective ATP production and attenuated pluripotency gene expression, leading to abnormal self-renewal and differentiation.	ros	91-94	autophagy related 3	Mus musculus	3-7
27576197-8	2016	We also demonstrated that the activation of STAT3 and gemcitabine-enhanced stemness was NADPH oxidase (Nox)-generated, ROS-dependent, and NF-kappaB partially mediated the process.	ros	119-122	signal transducer and activator of transcription 3	Homo sapiens	44-49
26585565-9	2016	In a similar manner, ROS production induced by high glucose was reduced by GLP-1 in the presence of PKCbeta inhibitor.	ros	21-24	glucagon	Homo sapiens	75-80
27709372-11	2016	Additional experiments demonstrated that H2O2 and catalase differentially regulate growth hormone and prolactin expression in somatolactotroph cells, confirming potential roles of ROS pathway on regulating somatotroph and lactotroph functions.	ros	180-183	catalase	Homo sapiens	41-58
27718420-9	2016	In particular, data presented suggest an important role for ERK pathway that could act directly by stimulating cell proliferation but can also induce both Nrf-2 and NF-kappaB activation, acting as a critical cellular checkpoint in response to imbalanced redox state generated by a laser induced increase in ROS production.	ros	307-310	mitogen-activated protein kinase 1	Mus musculus	60-63
27697723-10	2016	Taken together, our study demonstrates that the inhibitory effect of SZC015 against H322 cells is mediated by excessive ROS generation that could suppress Akt/NF-kappaB signaling pathway, which thereby leads to apoptotic and autophagic cell death.	ros	120-123	AKT serine/threonine kinase 1	Homo sapiens	155-158
27756472-9	2016	These results indicate that BHB induces bovine hepatocyte apoptosis through the ROS-p38-p53/Nrf2 signaling pathway.	ros	80-83	NFE2 like bZIP transcription factor 2	Bos taurus	92-96
27718420-9	2016	In particular, data presented suggest an important role for ERK pathway that could act directly by stimulating cell proliferation but can also induce both Nrf-2 and NF-kappaB activation, acting as a critical cellular checkpoint in response to imbalanced redox state generated by a laser induced increase in ROS production.	ros	307-310	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-160
27543848-7	2016	Inhibition of TLR2 or TLR4 reduced IL-6 production as well as expression of these other factors, and agents inhibiting ROS, MAPKs, NF-kappaB and JAK reduced IL-6 production.	ros	119-122	interleukin 6	Homo sapiens	157-161
27619661-10	2016	Further, we noticed that, knockdown of cFLIPL and induced expression of FADD rapidly accumulate intracellular ROS accompanied by JNK1 activation to substantiate apoptosis.	ros	110-113	CASP8 and FADD like apoptosis regulator	Homo sapiens	39-45
27793199-5	2016	RESULTS: HER-2 mutation was detected in 22/456 cases (4.8 %); the rate was 6.7 % among 331 triple-negative samples (i.e., wild-type EGFR, anaplastic lymphoma kinase, and ROS proto-oncogene 1).	ros	170-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-14
27730227-0	2016	Metal-catalyzed oxidation of Abeta and the resulting reorganization of Cu binding sites promote ROS production.	ros	96-99	amyloid beta precursor protein	Homo sapiens	29-34
27702549-5	2016	We identified thioredoxin interacting protein (TxNIP), which is overexpressed in T2DM, to be a promoter of ROS-induced IR.	ros	107-110	thioredoxin interacting protein	Homo sapiens	14-45
27702549-5	2016	We identified thioredoxin interacting protein (TxNIP), which is overexpressed in T2DM, to be a promoter of ROS-induced IR.	ros	107-110	thioredoxin interacting protein	Homo sapiens	47-52
27702549-6	2016	We observed upregulation of TxNIP upon palmitate treatment in skeletal muscle cells that led to ROS generation and Glut-4 downregulation resulting in impaired glucose-uptake.	ros	96-99	thioredoxin interacting protein	Homo sapiens	28-33
27775662-10	2016	Furthermore, we observed no significant alteration of apoptosis by CAP, whereas Catalase and SOD2 were considerably upregulated, which could clear ROS and protect against cell death.	ros	147-150	catalase	Mus musculus	80-88
27775662-10	2016	Furthermore, we observed no significant alteration of apoptosis by CAP, whereas Catalase and SOD2 were considerably upregulated, which could clear ROS and protect against cell death.	ros	147-150	superoxide dismutase 2, mitochondrial	Mus musculus	93-97
27568863-6	2016	We observed an increase in p53 levels, which was dependent on ROS production.	ros	62-65	tumor protein p53	Homo sapiens	27-30
27567855-8	2016	ROS was generated in all Cu(II)/Abeta complexes.	ros	0-3	amyloid beta precursor protein	Homo sapiens	32-37
27542250-2	2016	Recently, we have reported that increased mitochondrial fission promotes autophagy and apoptosis resistance in hepatocellular carcinoma (HCC) cell through ROS-mediated coordinated regulation of NF-kappaB and p53 pathways.	ros	155-158	nuclear factor kappa B subunit 1	Homo sapiens	194-203
27542250-2	2016	Recently, we have reported that increased mitochondrial fission promotes autophagy and apoptosis resistance in hepatocellular carcinoma (HCC) cell through ROS-mediated coordinated regulation of NF-kappaB and p53 pathways.	ros	155-158	tumor protein p53	Homo sapiens	208-211
27591797-1	2016	Regulation of ROS metabolism plays a major role in cellular adaptation to oxidative stress in cancer cells, but the molecular mechanism that regulates catalase, a key antioxidant enzyme responsible for conversion of hydrogen peroxide to water and oxygen, remains to be elucidated.	ros	14-17	catalase	Homo sapiens	151-159
27475664-5	2016	AOPPs stimulation induced ROS generation and NF-kappa B p65 phosphorylation, which could be inhibited by soluble receptor for advanced glycan end products (sRAGE), NADPH oxidase inhibitor (apocynin), ROS scavenger (N-acetyl-cysteine, NAC).	ros	200-203	nuclear factor kappa B subunit 1	Homo sapiens	45-55
27554111-6	2016	Further, C-peptide replacement therapy prevented persistent generation of ROS and ONOO(-) in the aorta of diabetic mice whose glucose levels were normalized by the administration of insulin.	ros	74-77	insulin	Homo sapiens	9-18
27286880-10	2016	The As(III) effects on HIF-1alpha were dependent on ROS, NOX4, PI3K/Akt, and ERK1/2.	ros	52-55	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
27702549-10	2016	Taken together, TxNIP appears to be an important factor in FFA-induced ROS generation and IR in skeletal muscle cells, which can be modulated for the management of this complex disorder.	ros	71-74	thioredoxin interacting protein	Homo sapiens	16-21
27568862-0	2016	Coagulin-L ameliorates TLR4 induced oxidative damage and immune response by regulating mitochondria and NOX-derived ROS.	ros	116-119	toll-like receptor 4	Mus musculus	23-27
27721446-6	2016	Minocycline stabilizes endogenous Nrf2 in kidneys of db/db mice, thus dampening ROS-induced inflammasome activation in the kidney.	ros	80-83	nuclear factor, erythroid derived 2, like 2	Mus musculus	34-38
27248006-0	2016	Anti-inflammatory effect of a resveratrol derivative 3,4,5-trimethoxy-4",5"-dihydroxy-trans-stilbene (WL-09-5) via ROS-mediated NF-kappaB pathway.	ros	115-118	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-137
27565029-11	2016	Moreover, AngII and miR-106a treatment cultured cardiomyocytes mitochondria presented cristae defects, considerable depolarization of mitochondrial membrane and increased ROS production.	ros	171-174	angiotensinogen	Homo sapiens	10-15
27687768-0	2016	Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways.	ros	126-129	angiotensinogen	Homo sapiens	28-42
27149969-6	2016	Moreover, they prevented apoptosis, in response to ROS, by restoring normal Bax/Bcl-2 ratio.	ros	51-54	BCL2, apoptosis regulator	Rattus norvegicus	80-85
27427241-7	2016	The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses.	ros	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	136-141
27427241-7	2016	The most potent metals, Cd(2+), Zn(2+) and As(3+) induced highest levels of oxidative activity, and ROS appeared to be central in their CXCL8 and IL-6 responses.	ros	100-103	interleukin 6	Homo sapiens	146-150
27687768-8	2016	These results indicate that Ang-(1-7) antagonizes the Ang II-induced VSMC proliferation, migration and inflammation through activation of Mas receptor and then suppression of ROS-dependent PI3K/Akt and MAPK/ERK signaling pathways.	ros	175-178	AKT serine/threonine kinase 1	Homo sapiens	194-197
27687768-0	2016	Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways.	ros	126-129	AKT serine/threonine kinase 1	Homo sapiens	144-147
27687768-8	2016	These results indicate that Ang-(1-7) antagonizes the Ang II-induced VSMC proliferation, migration and inflammation through activation of Mas receptor and then suppression of ROS-dependent PI3K/Akt and MAPK/ERK signaling pathways.	ros	175-178	mitogen-activated protein kinase 3	Homo sapiens	207-210
27687768-0	2016	Angiotensin-(1-7) abrogates angiotensin II-induced proliferation, migration and inflammation in VSMCs through inactivation of ROS-mediated PI3K/Akt and MAPK/ERK signaling pathways.	ros	126-129	mitogen-activated protein kinase 3	Homo sapiens	157-160
27624558-7	2016	Antioxidants (glutathione and N-Acetylcysteine), Cyp3a inhibitor ketoconazole and SLCO1B1 inhibitor gemfibrozil suppressed cytotoxicity and ROS formation in primary hepatocytes of diabetic rats.	ros	140-143	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	49-54
27711766-6	2016	An intimate relationship between p53, ROS production and extent of cell death has also been established using p53 wild, null and mutant type cancer cells.	ros	38-41	tumor protein p53	Homo sapiens	110-113
27552582-2	2016	Biological activity results demonstrated that compounds 5r and 5t exhibited potent inhibition and excellent selectivity toward acetylcholinesterase (AChE, 5r, IC50 = 0.204 muM, SI > 196; 5t, IC50 = 0.067 muM, SI > 597), specific metal-chelating ability, significant antioxidant effects, modulation of metal-induced Abeta aggregation, inhibition of ROS production by copper redox cycle, low cytotoxicity, and moderate neuroprotection to human neuroblastoma SH-SY5Y cells.	ros	348-351	acetylcholinesterase (Cartwright blood group)	Homo sapiens	149-153
27722045-9	2016	Mechanistically, Bcl-2 inhibitor ABT-199 impairs mitochondrial functions as shown by the decreased levels of mitochondrial membrane potential, mitochondrial respiration and ATP, and the increased levels of ROS in OTSCC cells.	ros	206-209	B cell leukemia/lymphoma 2	Mus musculus	17-22
27484784-0	2016	Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.	ros	201-204	activating transcription factor 4	Rattus norvegicus	0-33
27484784-0	2016	Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.	ros	201-204	activating transcription factor 4	Rattus norvegicus	35-39
27477351-11	2016	SIGNIFICANCE: The present study revealed that VD2 blocked the phosphorylation of NF-kappaB inflammatory signaling pathway in Abeta25-35 induced activated BV2 microglial cells by suppressing ROS generation and inflammatory cytokines.	ros	190-193	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
27618966-3	2016	RESULTS: Using Caenorhabditis elegans, we show that a hif-1 loss-of-function mutation confers resistance towards the mitochondrial toxin ethidium bromide (EtBr) and suppresses EtBr-induced production of ROS.	ros	203-206	Hypoxia-inducible factor 1	Caenorhabditis elegans	54-59
32263487-4	2016	The internalized BSeC@MSNs-RGD triggered mitochondrial dysfunction and intracellular ROS overproduction, which subsequently activated the p53 and MAPKs pathways.	ros	85-88	tumor protein p53	Homo sapiens	138-141
27669008-4	2016	In control BM (n = 24), ROS levels were highest in granulocyte-macrophage progenitors (GMP) and CD34- myeloid precursors but megakaryocyte-erythroid progenitors had equivalent levels to CD34+CD38low immature-SPC although they were ki67high.	ros	24-27	CD34 molecule	Homo sapiens	96-100
27669008-4	2016	In control BM (n = 24), ROS levels were highest in granulocyte-macrophage progenitors (GMP) and CD34- myeloid precursors but megakaryocyte-erythroid progenitors had equivalent levels to CD34+CD38low immature-SPC although they were ki67high.	ros	24-27	CD34 molecule	Homo sapiens	186-190
27669008-7	2016	Erythroid CD34- precursors were, however, abnormally ROS-high in MDS-noEB, potentially linking oxidative stress to cell loss.	ros	53-56	CD34 molecule	Homo sapiens	10-14
27669008-9	2016	However ROS levels varied between AMLs; Flt3ITD+/NPM1wild-type CD34+SPC had higher ROS than NPM1mutated CD34+ or CD34- SPC.	ros	8-11	CD34 molecule	Homo sapiens	63-67
27669008-9	2016	However ROS levels varied between AMLs; Flt3ITD+/NPM1wild-type CD34+SPC had higher ROS than NPM1mutated CD34+ or CD34- SPC.	ros	83-86	CD34 molecule	Homo sapiens	63-67
27669008-11	2016	Some patients had BCL2 overexpression in CD34+ ROS-high as well as ROS-low fractions which may be indicative of poor early response to standard chemotherapy.	ros	47-50	BCL2 apoptosis regulator	Homo sapiens	18-22
27899819-6	2016	Further investigation showed that 4-cholesten-3-one promoted ROS generation, which transiently activated AMPKalpha1, increased HIF1alpha expression, reduced Bcl-2 expression and caused autophagy.	ros	61-64	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-136
27899819-6	2016	Further investigation showed that 4-cholesten-3-one promoted ROS generation, which transiently activated AMPKalpha1, increased HIF1alpha expression, reduced Bcl-2 expression and caused autophagy.	ros	61-64	BCL2 apoptosis regulator	Homo sapiens	157-162
27624558-8	2016	In HepG2 cells, up-regulations of CYP3A4 and SLCO1B1 potentiated hepatotoxicity and ROS generation, whereas knockdowns of CYP3A4 and SLCO1B1 as well as CYP3A4/SLCO1B1 inhibitions showed the opposite effects.	ros	84-87	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	34-40
27624558-11	2016	All these findings demonstrated that the upregulations of hepatic Cyp3a and SLCO1B1 in diabetic rats potentiated atorvastatin-induced hepatotoxicity via increasing ROS formation.	ros	164-167	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	66-71
27394920-7	2016	Exposure to 1 muM Ang II for 24 h resulted in mitochondrial depolarization, cytochrome c release, and increased ROS production.	ros	112-115	angiotensinogen	Homo sapiens	18-24
27618431-9	2016	We demonstrated that miR-223 overexpression promoted TRAIL-induced apoptosis through the mitochondria/ROS pathway.	ros	102-105	TNF superfamily member 10	Homo sapiens	53-58
27396622-6	2016	Moreover, Homer1 knockdown attenuated t-BHP-induced ROS generation, lipid peroxidation and mitochondrial dysfunction, as evidenced by loss of mitochondrial membrane potential (MMP), ATP synthesis collapse and mitochondrial swelling.	ros	52-55	homer scaffolding protein 1	Mus musculus	10-16
27264312-0	2016	Novel CHOP activator LGH00168 induces necroptosis in A549 human lung cancer cells via ROS-mediated ER stress and NF-kappaB inhibition.	ros	86-89	DNA damage inducible transcript 3	Homo sapiens	6-10
27607584-6	2016	Hypoxia-induced inflammatory cytokine, growth factor and NOX1/4 upregulation, as well as increased ROS production and apoptosis in ADSCs were dependent on TLR4 and Nrf2, which also modulated the effect of ADSCs on promoting endothelial progenitor cell migration and angiogenesis.	ros	99-102	toll-like receptor 4	Mus musculus	155-159
27607584-6	2016	Hypoxia-induced inflammatory cytokine, growth factor and NOX1/4 upregulation, as well as increased ROS production and apoptosis in ADSCs were dependent on TLR4 and Nrf2, which also modulated the effect of ADSCs on promoting endothelial progenitor cell migration and angiogenesis.	ros	99-102	nuclear factor, erythroid derived 2, like 2	Mus musculus	164-168
27364555-3	2016	Diverse metabolic stresses induced Ser473 phosphorylation of KAP1 (pS473-KAP1) in a ROS- and p38-dependent manner.	ros	84-87	tripartite motif containing 28	Homo sapiens	61-65
27582555-0	2016	Isoegomaketone Upregulates Heme Oxygenase-1 in RAW264.7 Cells via ROS/p38 MAPK/Nrf2 Pathway.	ros	66-69	heme oxygenase 1	Mus musculus	27-43
27582555-8	2016	ROS scavengers (N-acetyl-L-cysteine, NAC, and glutathione, GSH) also blocked the IK-induced ROS production and HO-1 expression.	ros	0-3	heme oxygenase 1	Mus musculus	111-115
27582555-11	2016	Taken together, it can be concluded that IK induced the HO-1 expression through the ROS/p38 MAPK/ Nrf2 pathway in RAW264.7 cells.	ros	84-87	heme oxygenase 1	Mus musculus	56-60
27416292-0	2016	Berberine reverses lapatinib resistance of HER2-positive breast cancer cells by increasing the level of ROS.	ros	104-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-47
27364555-3	2016	Diverse metabolic stresses induced Ser473 phosphorylation of KAP1 (pS473-KAP1) in a ROS- and p38-dependent manner.	ros	84-87	tripartite motif containing 28	Homo sapiens	67-77
27364555-5	2016	Mechanistic investigations using phosphorylation-defective mutants revealed that KAP1 Ser473 phosphorylation limited mitochondrial hyperfusion in glucose-starved breast cancer cells, as driven by downregulation of the mitofusin protein MFN2, leading to reduced oxidative phosphorylation and ROS production.	ros	291-294	tripartite motif containing 28	Homo sapiens	81-85
30034766-6	2016	The reduced ERK1/2 phosphorylation induced by the specific SOD1 inactivation-mediated decrease of intracellular H2O2 levels reveals the potential of these specific SOD1 inhibitors in understanding and regulating ROS signaling.	ros	212-215	mitogen-activated protein kinase 3	Homo sapiens	12-18
30034766-6	2016	The reduced ERK1/2 phosphorylation induced by the specific SOD1 inactivation-mediated decrease of intracellular H2O2 levels reveals the potential of these specific SOD1 inhibitors in understanding and regulating ROS signaling.	ros	212-215	superoxide dismutase 1	Homo sapiens	59-63
30034766-0	2016	The rational design of specific SOD1 inhibitors via copper coordination and their application in ROS signaling research.	ros	97-100	superoxide dismutase 1	Homo sapiens	32-36
27166683-3	2016	TFAM is a gene regulator that acts to mitigate calcium mishandling and ROS production by wrapping around mitochondrial DNA (mtDNA) complexes.	ros	71-74	transcription factor A, mitochondrial	Homo sapiens	0-4
27414741-0	2016	ROS-mediated apoptosis of HAPI microglia through p53 signaling following PFOS exposure.	ros	0-3	tumor protein p53	Homo sapiens	49-52
27414741-6	2016	Interestingly, NAC, a ROS inhibitor, inhibited p53 expression, and decreased the apoptosis of HAPI microglia.	ros	22-25	tumor protein p53	Homo sapiens	47-50
27414741-7	2016	Taken together, these findings suggest that upregulated production of ROS plays a vital role in PFOS-mediated apoptosis in HAPI microglia via the modulation of p53 signaling.	ros	70-73	tumor protein p53	Homo sapiens	160-163
30034766-6	2016	The reduced ERK1/2 phosphorylation induced by the specific SOD1 inactivation-mediated decrease of intracellular H2O2 levels reveals the potential of these specific SOD1 inhibitors in understanding and regulating ROS signaling.	ros	212-215	superoxide dismutase 1	Homo sapiens	164-168
27481486-0	2016	Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.	ros	17-20	treacle ribosome biogenesis factor 1	Mus musculus	22-27
27481486-0	2016	Face off against ROS: Tcof1/Treacle safeguards neuroepithelial cells and progenitor neural crest cells from oxidative stress during craniofacial development.	ros	17-20	treacle ribosome biogenesis factor 1	Mus musculus	28-35
27166683-6	2016	TFAM"s regulatory role over ROS production and calcium mishandling leads to further investigation into the cardioprotective role of exogenous TFAM.	ros	28-31	transcription factor A, mitochondrial	Homo sapiens	0-4
27554094-14	2016	Interestingly, CREB was activated in the ECM brain and may protect against ROS/RNS stress.	ros	75-78	cAMP responsive element binding protein 1	Mus musculus	15-19
27411561-3	2016	Insulin induces ROS formation in several cell types.	ros	16-19	insulin	Homo sapiens	0-7
27411561-7	2016	Insulin (100nM) for 24h selectively increased the production of ROS in pancreatic cells and isolated pancreatic islets, but only slightly affected the expression of antioxidant enzymes.	ros	64-67	insulin	Homo sapiens	0-7
27264783-3	2016	Our findings suggest that PMA or diamide induced oxidative stress in PMNs from healthy volunteers, and high endogenous ROS in PMNs of chronic myeloid leukemia (CML) patients attenuate basal as well as LPS/cytokines induced NO generation and iNOS expression in human PMNs.	ros	119-122	nitric oxide synthase 2	Homo sapiens	241-245
27264783-5	2016	Furthermore, by using pharmacological inhibitors, scavengers and molecular approaches, we identified that enhanced ROS generation via NOX2 and mitochondria, reduced Grx1/2 expression and GSH level associated with NFkappaB S-glutathionylation in PMNs from CML patients.	ros	115-118	nuclear factor kappa B subunit 1	Homo sapiens	213-221
27573788-6	2016	Induction of miRNA-328 expression during cell differentiation antagonizes the blockade by hnRNP E2 which results in the upregulation of CD11b expression and ROS production in monocytic cells.	ros	157-160	poly(rC) binding protein 2	Homo sapiens	90-98
27378626-7	2016	Biochemical evidence of apoptosis came from elevating the intracellular ROS level that was accompanied by mitochondrial membrane potential loss, decreasing the expression profile of anti-apoptotic protein Bcl-2, whereas it augments cleavage of caspase-3 and PARP-1, activates caspase-8 and 9 with concomitant increase in expression of proapoptotic protein Bax in a dose dependent manner.	ros	72-75	BCL2 apoptosis regulator	Homo sapiens	205-210
27378626-7	2016	Biochemical evidence of apoptosis came from elevating the intracellular ROS level that was accompanied by mitochondrial membrane potential loss, decreasing the expression profile of anti-apoptotic protein Bcl-2, whereas it augments cleavage of caspase-3 and PARP-1, activates caspase-8 and 9 with concomitant increase in expression of proapoptotic protein Bax in a dose dependent manner.	ros	72-75	poly(ADP-ribose) polymerase 1	Homo sapiens	258-264
27378626-7	2016	Biochemical evidence of apoptosis came from elevating the intracellular ROS level that was accompanied by mitochondrial membrane potential loss, decreasing the expression profile of anti-apoptotic protein Bcl-2, whereas it augments cleavage of caspase-3 and PARP-1, activates caspase-8 and 9 with concomitant increase in expression of proapoptotic protein Bax in a dose dependent manner.	ros	72-75	BCL2 associated X, apoptosis regulator	Homo sapiens	356-359
27687650-7	2016	CONCLUSION: Bisoprolol can protect H9c2 cells against H/R-induced injury and oxidative stress by activating PI3K/AKT/Gsk-3beta pathway to increase the phosphorylation of AKT and GSK3beta and reduce ROS production.	ros	198-201	AKT serine/threonine kinase 1	Rattus norvegicus	170-173
27349676-5	2016	In vitro studies on the HT-29 human colon cancer cell line, MEF mice embryonic fibroblasts, and MEF with the knocked-out Atox1 gene (Atox1-/-) consistently identified C3U/C6U as the most potent inhibitor of ROS cellular production based on the 2",7"-dichlorodihydrofluorescin diacetate (H2DCF-DA) assay, also in comparison with known drugs employed in the clinic for Wilson"s disease.	ros	207-210	antioxidant 1 copper chaperone	Mus musculus	121-126
27364911-6	2016	FGF21 inhibited Ang II-enhanced ROS production/superoxide anion levels, rescued the Ang II-reduced Complex IV and citrate synthase activities, and suppressed the Ang II-induced meprin protein expression.	ros	32-35	fibroblast growth factor 21	Homo sapiens	0-5
27164560-8	2016	Consequently, NSD2-driven tamoxifen-resistant cells and tumors displayed heightened PPP activity, elevated NADPH production, and reduced ROS level, without significantly altered glycolysis.	ros	137-140	nuclear receptor binding SET domain protein 2	Homo sapiens	14-18
27513743-0	2016	Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity.	ros	111-114	signal transducer and activator of transcription 3	Homo sapiens	22-27
27349676-5	2016	In vitro studies on the HT-29 human colon cancer cell line, MEF mice embryonic fibroblasts, and MEF with the knocked-out Atox1 gene (Atox1-/-) consistently identified C3U/C6U as the most potent inhibitor of ROS cellular production based on the 2",7"-dichlorodihydrofluorescin diacetate (H2DCF-DA) assay, also in comparison with known drugs employed in the clinic for Wilson"s disease.	ros	207-210	antioxidant 1 copper chaperone	Mus musculus	133-138
27496964-0	2016	Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.	ros	56-59	DNA damage inducible transcript 3	Homo sapiens	64-68
27337687-6	2016	Moreover, a decrease in the NAD(+):NADH ratio and increase in intracellular ROS content after treatment with palmitic acid in combination with lipopolysaccharide were more pronounced in Mphis from Atg7 cKO mice, suggesting that mitochondrial dysfunction in autophagy-deficient Mphis leads to an increase in lipid-induced inflammasome and metabolic deterioration in Atg7 cKO-ob/ob mice.	ros	76-79	autophagy related 7	Mus musculus	197-201
27493727-0	2016	Malonate as a ROS product is associated with pyruvate carboxylase activity in acute myeloid leukaemia cells.	ros	14-17	pyruvate carboxylase	Homo sapiens	45-65
27540389-8	2016	Virus-induced gene silencing-mediated silencing of SlTPS3, SlTPS4, or SlTPS7 led to deregulation of ROS accumulation and attenuated the expression of defense-related genes upon pathogen infection and thus deteriorated the resistance against B. cinerea or Pst DC3000.	ros	100-103	(-)-camphene/tricyclene synthase, chloroplastic	Solanum lycopersicum	51-57
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	ros	74-77	pyruvate carboxylase	Homo sapiens	26-28
27493727-9	2016	Moreover, our studies indicate that the PC activity in cancer cells can be exploited as an Achilles heel by using treatments, such as BaP, that elevate ROS production.	ros	152-155	pyruvate carboxylase	Homo sapiens	40-42
27317889-10	2016	Taken together, we concluded that aldosterone-mediated tissue fibrosis relies on ROS induced EGFR/ERK activation, highlighting EGFR as a potential therapeutic target for modulating renal fibrosis.	ros	81-84	Eph receptor B1	Rattus norvegicus	98-101
27208785-0	2016	Overexpression of HDAC6 induces pro-inflammatory responses by regulating ROS-MAPK-NF-kappaB/AP-1 signaling pathways in macrophages.	ros	73-76	histone deacetylase 6	Mus musculus	18-23
27109518-0	2016	Apocynin attenuates renal fibrosis via inhibition of NOXs-ROS-ERK-myofibroblast accumulation in UUO rats.	ros	58-61	Eph receptor B1	Rattus norvegicus	62-65
27208785-4	2016	HDAC6 overexpression significantly induced ROS generation via upregulation of NADPH oxidase expression and activity.	ros	43-46	histone deacetylase 6	Mus musculus	0-5
27208785-5	2016	Inhibition of ROS generation by N-acetyl cysteine, diphenyl iodonium and apocynin suppressed HDAC6-induced pro-inflammatory cytokines.	ros	14-17	histone deacetylase 6	Mus musculus	93-98
26592091-9	2016	Furthermore, the levels of ROS and oxidative stress were remarkably higher in Nrf2 KO than WT lungs under a physiological condition, and were dramatically increased by MWCNT, with the increase significantly more striking in KO lungs.	ros	27-30	nuclear factor, erythroid derived 2, like 2	Mus musculus	78-82
27208785-6	2016	An HDAC6 enzymatic inhibitor significantly inhibited ROS generation and expression of HDAC6-induced pro-inflammatory mediators, indicating the requirement of HDAC6 enzymatic activity for induction of pro-inflammatory cytokines.	ros	53-56	histone deacetylase 6	Mus musculus	3-8
27208785-9	2016	Overall, our results provide the first evidence that HDAC6 is capable of inducing expression of pro-inflammatory genes by regulating the ROS-MAPK-NF-kappaB/AP-1 pathways and serves as a molecular target for inflammation.	ros	137-140	histone deacetylase 6	Mus musculus	53-58
26961468-4	2016	Mechanistic investigation revealed that RGD-NPs inhibited angiogenesis through induction of apoptosis and cell cycle arrest in human umbilical vein endothelial cells (HUVECs) via suppression of VEGF-VEGFR2-ERK/AKT signaling axis by triggering ROS-mediated DNA damage.	ros	243-246	vascular endothelial growth factor A	Homo sapiens	194-198
27288283-8	2016	Furthermore, we have also shown that NCP-induced GSH decrease activated the Nrf2 pathway and its downstream targets NAD(P)H: quinone oxidoreductase (NQO-1) and glutamate cysteine ligase modifier subunit (GCLm), thus explaining the fast restoration of GSH pool and ROS decrease.	ros	264-267	NFE2 like bZIP transcription factor 2	Homo sapiens	76-80
27288283-8	2016	Furthermore, we have also shown that NCP-induced GSH decrease activated the Nrf2 pathway and its downstream targets NAD(P)H: quinone oxidoreductase (NQO-1) and glutamate cysteine ligase modifier subunit (GCLm), thus explaining the fast restoration of GSH pool and ROS decrease.	ros	264-267	NAD(P)H quinone dehydrogenase 1	Homo sapiens	149-154
27288283-8	2016	Furthermore, we have also shown that NCP-induced GSH decrease activated the Nrf2 pathway and its downstream targets NAD(P)H: quinone oxidoreductase (NQO-1) and glutamate cysteine ligase modifier subunit (GCLm), thus explaining the fast restoration of GSH pool and ROS decrease.	ros	264-267	glutamate-cysteine ligase modifier subunit	Homo sapiens	160-202
27422544-6	2016	ROS promotes p53 inducing MALM (Mieap-induced accumulation of lysosome-like organelles within mitochondria) to repair dysfunctional mitochondria and MIV (Mieap-induced vacuole) to accomplish damaged mitochondria degradation.	ros	0-3	tumor protein p53	Homo sapiens	13-16
27270321-6	2016	In the cells subjected to hypoxia, inhibition of Sirt3-mediated mitophagy further decreased the mitochondrial membrane potential, and increased the accumulation of ROS that triggers the degradation of anti-apoptotic proteins Mcl-1 and survivin through the proteasomal pathway.	ros	164-167	sirtuin 3	Homo sapiens	49-54
27300444-0	2016	Hydrogen peroxide prevents vascular calcification induced ROS production by regulating Nrf-2 pathway.	ros	58-61	NFE2 like bZIP transcription factor 2	Homo sapiens	87-92
27300444-8	2016	CONCLUSION: Our study demonstrates that 0.01 mM hydrogen peroxide can effectively protect rat aortic vascular smooth muscle cells against oxidative stress by preventing vascular calcification induced ROS production through Nrf-2 pathway.	ros	200-203	NFE2 like bZIP transcription factor 2	Rattus norvegicus	223-228
27439459-7	2016	(3) The chloroplast ROS signaling marker genes ZAT10 and BAP1 were less activated by the triggering stimulus in primed plants.	ros	20-23	salt tolerance zinc finger	Arabidopsis thaliana	47-52
27184504-8	2016	Moreover, the inhibitory effect was found to be mostly dependent on Nrf2 which decreased mitochondrial ROS (mROS) generation and mitochondrial DNA (mtDNA) release.	ros	103-106	nuclear factor, erythroid derived 2, like 2	Mus musculus	68-72
26795735-8	2016	TrxR was shown to regulate HO-1 via the Nrf2 signaling pathway in a ROS-dependent manner.	ros	68-71	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
27435304-7	2016	Similarly, in-vitro study, LPS mediated ROS-induced U-87 cells, omeprazole reduced the oxidative stress as well as the release of TNF-alpha, IL-1beta and IL-6.	ros	40-43	interleukin 6	Rattus norvegicus	154-158
32263394-4	2016	Furthermore, the nanosystem (Bio-PLGA@Ru) was efficiently internalized by cancer cells by the lipid raft-mediated endocytosis pathway, triggered ROS overproduction and activated p53-mediated apoptosis in cancer cells.	ros	145-148	tumor protein p53	Homo sapiens	178-181
27068641-0	2016	High glucose induces autophagy of MC3T3-E1 cells via ROS-AKT-mTOR axis.	ros	53-56	thymoma viral proto-oncogene 1	Mus musculus	57-60
27402251-3	2016	Re-expression of ERRalpha in resistant cells triggers metabolic adaptations favouring mitochondrial energy metabolism through increased glutamine metabolism, as well as ROS detoxification required for cell survival under therapeutic stress conditions.	ros	169-172	estrogen related receptor alpha	Homo sapiens	17-25
27392019-0	2016	Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation.	ros	95-98	mitogen-activated protein kinase 1	Homo sapiens	109-112
27392019-0	2016	Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation.	ros	95-98	mitogen-activated protein kinase 8	Homo sapiens	117-120
27068641-1	2016	In the present study, we investigate the function of ROS-AKT-mTOR axis on the apoptosis, proliferation and autophagy of MC3T3-E1 cells, and the proliferation of MC3T3-E1 cells after autophagy inhibition under high glucose conditions.	ros	53-56	thymoma viral proto-oncogene 1	Mus musculus	57-60
27166188-7	2016	ME2 has two cofactors, NAD+ or NADP+, which are used to produce NADH and NADPH for ATP production and ROS clearance, respectively.	ros	102-105	malic enzyme 2	Homo sapiens	0-3
27068641-15	2016	Our present findings reveal that high glucose affects apoptosis, proliferation and autophagy of MC3T3-E1 cells through ROS-AKT-mTOR axis.	ros	119-122	thymoma viral proto-oncogene 1	Mus musculus	123-126
27206672-8	2016	The other strategy was observed in clone A7 and C10, where ROS levels were maintained reversing malignant features.	ros	59-62	homeobox C10	Homo sapiens	48-51
27373231-5	2016	Overexpression of Bmi1 in Pthrp(KI/KI) mice resulted in a longer lifespan, increased body weight and improvement in skeletal growth and parameters of osteoblastic bone formation with reduced ROS levels and DNA damage response parameters.	ros	191-194	Bmi1 polycomb ring finger oncogene	Mus musculus	18-22
27470954-11	2016	CONCLUSIONS: This work highlights that ALS alters SOD1 protein expression, mitochondrial function, and increases the ROS level even in peripheral tissues outside the central nervous system.	ros	117-120	superoxide dismutase 1	Homo sapiens	39-42
27321752-8	2016	These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis.	ros	94-97	NLR family pyrin domain containing 3	Homo sapiens	180-185
27179140-6	2016	We observed TLR2 induction leads to MK maturation and is involved in production of ROS which is essential for MK development.	ros	83-86	toll like receptor 2	Homo sapiens	12-16
26844974-8	2016	Superoxide dismutase (SOD) inhibitable reduction of Cytochrome-C, dihydro carboxy fluorescein (DCF), and Mitosox was used to estimate ROS.	ros	134-137	superoxide dismutase 1	Homo sapiens	0-20
26844974-8	2016	Superoxide dismutase (SOD) inhibitable reduction of Cytochrome-C, dihydro carboxy fluorescein (DCF), and Mitosox was used to estimate ROS.	ros	134-137	superoxide dismutase 1	Homo sapiens	22-25
26844974-13	2016	LPS alone resulted in an insignificant increase in ROS production as measured by cytochrome C that was increased 4.6-fold by ET-1 stimulation (P &lt; 0.05).	ros	51-54	endothelin 1	Homo sapiens	125-129
26844974-14	2016	L-NIO significantly decreased ET-1-induced ROS production (P &lt; 0.05).	ros	43-46	endothelin 1	Homo sapiens	30-34
27224916-6	2016	ChREBP promoted leukemia cell differentiation through the direct inhibition of RUNX1 or the transactivation of TXNIP to downregulate the RUNX1 level and ROS generation.	ros	153-156	MLX interacting protein like	Homo sapiens	0-6
27224916-6	2016	ChREBP promoted leukemia cell differentiation through the direct inhibition of RUNX1 or the transactivation of TXNIP to downregulate the RUNX1 level and ROS generation.	ros	153-156	thioredoxin interacting protein	Homo sapiens	111-116
27166596-0	2016	Corrigendum to "Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1-AMPK-mTOR pathway" [Atherosclerosis 243 (1) (2015) 223-235].	ros	68-71	mechanistic target of rapamycin kinase	Homo sapiens	99-103
27365551-8	2016	The treatment of the THP-1-differentiated cells with ESAT-6, CFP-10, and ESAT-6/CFP-10 reduced NO and ROS production.	ros	102-105	GLI family zinc finger 2	Homo sapiens	21-26
27220901-3	2016	Whether globular adiponectin (gAd), a potent molecule protective to mitochondria, regulates the mitochondrial function of alveolar type II cells to reduce PQ-induced ROS/RNS production remains to be investigated.	ros	166-169	adiponectin, C1Q and collagen domain containing	Homo sapiens	17-28
27321752-8	2016	These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis.	ros	94-97	absent in melanoma 2	Homo sapiens	190-194
27378947-7	2016	have shown that dysregulation of Nrf2 severely affects the oxidant/ROS sensitivity and predispose the system to several pathological changes with aberrant cellular lesions.	ros	67-70	NFE2 like bZIP transcription factor 2	Homo sapiens	33-37
27321752-8	2016	These results indicate that in case of HIV infected macrophages exposed to cocaine, increased ROS production and IL-1beta transcription serve as an activators for the formation of NLRP3 and AIM2 mediated inflammasomes that leads to caspase 1 mediated apoptosis.	ros	94-97	caspase 1	Homo sapiens	232-241
26819450-12	2016	Inactivation of HIF1/NDUFA4L2 increased mitochondrial activity and oxygen consumption, resulting in ROS accumulation and apoptosis.	ros	100-103	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-20
27363651-8	2016	Inhibition of Nrf2 and glutathione synthesis significantly suppressed NG-induced decrease of ROS level.	ros	93-96	NFE2 like bZIP transcription factor 2	Rattus norvegicus	14-18
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	ros	126-129	microRNA 27a	Homo sapiens	130-137
27167341-10	2016	Taken together, SDF-1alpha and IL-6 secreted from PSC induced PDAC cell proliferation via Nrf2-activated metabolic reprogramming and ROS detoxification.	ros	133-136	interleukin 6	Homo sapiens	31-35
27295076-8	2016	CNI-induced TLR4 activity increased O2(-)/ROS production and NF-kappaB-regulated synthesis of proinflammatory factors in cultured as well as aortic endothelial and VSMCs.	ros	42-45	toll-like receptor 4	Mus musculus	12-16
27124102-0	2016	Increased mitochondrial fission promotes autophagy and hepatocellular carcinoma cell survival through the ROS-modulated coordinated regulation of the NFKB and TP53 pathways.	ros	106-109	tumor protein p53	Homo sapiens	159-163
27124102-7	2016	We further demonstrated that the survival-promoting role of increased mitochondrial fission was mediated via elevated ROS production and subsequent activation of AKT, which facilitated MDM2-mediated TP53 degradation, and NFKBIA- and IKK-mediated transcriptional activity of NFKB in HCC cells.	ros	118-121	tumor protein p53	Homo sapiens	199-203
27124102-7	2016	We further demonstrated that the survival-promoting role of increased mitochondrial fission was mediated via elevated ROS production and subsequent activation of AKT, which facilitated MDM2-mediated TP53 degradation, and NFKBIA- and IKK-mediated transcriptional activity of NFKB in HCC cells.	ros	118-121	NFKB inhibitor alpha	Homo sapiens	221-228
27108344-5	2016	Meanwhile, the ROS scavenger N-acetyl-L-cysteine (NAC) and the Jnk inhibitor SP600125 were found to inhibit the MPPa-PDT-induced autophagy, and NAC could also inhibit Jnk phosphorylation.	ros	15-18	mitogen-activated protein kinase 8	Homo sapiens	167-170
26502273-6	2016	Graphene activates apoptosis in macrophages through the TGFbr/Smad/Bcl-2 pathway and also through JNK kinases that are stimulated by an increase of ROS in the cell or through a signal received by Smad proteins.	ros	148-151	mitogen-activated protein kinase 8	Homo sapiens	98-101
27108344-8	2016	Meanwhile the ROS-Jnk signaling pathway was involved in MPPa-PDT-induced autophagy, which further promoted the apoptosis in MG-63 cells.	ros	14-17	mitogen-activated protein kinase 8	Homo sapiens	18-21
26975633-3	2016	Importantly, the poly-[ADP-ribose] polymerase-1 (PARP-1) enzyme plays an important role in the repair of ROS-induced DNA damage.	ros	105-108	poly(ADP-ribose) polymerase 1	Homo sapiens	17-47
26138683-7	2016	HT-2 toxin exposure also induced oxidative stress and resulted in oocyte apoptosis, as shown by ROS accumulation, increased SOD mRNA level, and the expression of the early apoptosis marker Annexin V and increased caspase-3 and bax mRNA levels.	ros	96-99	hypothermia due to alcohol sensitivity 2	Mus musculus	0-4
26947057-5	2016	Transformation of Deltapor1 yeast with human SOD1 completely restores the cell growth deficit in non-fermentative conditions and re-establishes the physiological levels of ROS, as well as the mitochondrial membrane potential.	ros	172-175	superoxide dismutase 1	Homo sapiens	45-49
27058876-6	2016	HIF-1alpha signaling limits oxygen consumption to avoid accumulation of harmful ROS and preserve redox balance, and additionally induces a switch to glycolysis to prevent energetic distress.	ros	80-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
26952810-4	2016	MIF-induced ROS led to ERK phosphorylation, which facilitated HMGB1 release from the nucleus to the cytoplasm.	ros	12-15	mitogen-activated protein kinase 1	Homo sapiens	23-26
26975633-3	2016	Importantly, the poly-[ADP-ribose] polymerase-1 (PARP-1) enzyme plays an important role in the repair of ROS-induced DNA damage.	ros	105-108	poly(ADP-ribose) polymerase 1	Homo sapiens	49-55
26975633-8	2016	The combined treatment of APR-246 and olaparib induced cell death that was associated with increased ROS production, accumulation of DNA damage and translocation of p53 to the mitochondria.	ros	101-104	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	26-29
26935109-13	2016	POMC-Ptp1b deletion increases plasma TNF-alpha levels, which contribute to body weight regulation via increased energy expenditure and impair endothelial function via COX-2 and ROS-dependent mechanisms.	ros	177-180	tumor necrosis factor	Mus musculus	37-46
27048819-8	2016	Increased production of ROS can further trigger other necrotic pathways mediated through molecules such as PARP1, leading to irreversible cell damage.	ros	24-27	poly(ADP-ribose) polymerase 1	Homo sapiens	107-112
26715278-0	2016	ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.	ros	92-95	mitogen-activated protein kinase 1	Homo sapiens	0-3
27250627-16	2016	CONCLUSIONS: Anti-dsDNA Abs activated NLRP3 inflammasome in monocytes/macrophages from SLE patients by binding to TLR4 and inducing the production of mitochondrial ROS.	ros	164-167	NLR family pyrin domain containing 3	Homo sapiens	38-43
26086416-7	2016	Blockage of ROS production totally reversed WZ26-induced JNK activation, Bcl-2/Bax decrease, ER stress activation, and final cell apoptosis in SGC-7901 cells.	ros	12-15	mitogen-activated protein kinase 8	Homo sapiens	57-60
26086416-7	2016	Blockage of ROS production totally reversed WZ26-induced JNK activation, Bcl-2/Bax decrease, ER stress activation, and final cell apoptosis in SGC-7901 cells.	ros	12-15	BCL2 apoptosis regulator	Homo sapiens	73-78
26086416-7	2016	Blockage of ROS production totally reversed WZ26-induced JNK activation, Bcl-2/Bax decrease, ER stress activation, and final cell apoptosis in SGC-7901 cells.	ros	12-15	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	signal transducer and activator of transcription 3	Homo sapiens	109-114
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	115-118
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	signal transducer and activator of transcription 3	Homo sapiens	119-124
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	tumor protein p53	Homo sapiens	208-211
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	caspase 3	Homo sapiens	232-241
27083311-5	2016	Furthermore, in HaCaT keratinocytes treated with H2O2, 1,25(OH)2D3, 21(OH)pD and calcipotriol stimulated the expression of SOD1 and CAT genes, but not SOD2, indicating a possible role of mitochondria in ROS-modulated cell death.	ros	203-206	superoxide dismutase 1	Homo sapiens	123-127
26715278-0	2016	ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.	ros	92-95	mitogen-activated protein kinase 1	Homo sapiens	83-86
26715278-0	2016	ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway.	ros	92-95	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
26715278-7	2016	OA was shown to promote ERK-dependent Nrf2 expression in cancer cells, and in turn, Nrf2 expression was able to suppress OA-induced ROS generation.	ros	132-135	mitogen-activated protein kinase 1	Homo sapiens	24-27
26715278-7	2016	OA was shown to promote ERK-dependent Nrf2 expression in cancer cells, and in turn, Nrf2 expression was able to suppress OA-induced ROS generation.	ros	132-135	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
26715278-7	2016	OA was shown to promote ERK-dependent Nrf2 expression in cancer cells, and in turn, Nrf2 expression was able to suppress OA-induced ROS generation.	ros	132-135	NFE2 like bZIP transcription factor 2	Homo sapiens	84-88
26715278-8	2016	Blockade of Nrf2 expression was able to increase ROS levels and apoptotic death in cancer cells.	ros	49-52	NFE2 like bZIP transcription factor 2	Homo sapiens	12-16
27303303-8	2016	In addition, our results showed that AAT injection exhibited an anti-oxidative stress role by significantly reducing PE mediated-upregulation of ROS, MMP9 and MDA, and increasing the levels of SOD, eNOS, and GPx with increased dosage of AAT.	ros	145-148	serpin family A member 1	Homo sapiens	37-40
27222705-0	2016	Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.	ros	101-104	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
27222705-16	2016	CONCLUSION: Exogenous H2S might protect arterial endothelial cells by suppressing excessive autophagy induced by oxidative stress through the Nrf2-ROS-AMPK signaling pathway.	ros	147-150	NFE2 like bZIP transcription factor 2	Homo sapiens	142-146
27173006-0	2016	SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta1 via ROS/p38 MAPK/STAT3 pathway.	ros	93-96	transforming growth factor beta 1	Homo sapiens	79-88
27144436-7	2016	Both NR4A1 knockdown and treatment with DIM-C-pPhOH and DIM-C-pPhCO2Me also induced ROS which activated stress genes and induced sestrin 2 which activated AMPK and inhibited mTOR in the mutant p53 RMS cells.	ros	84-87	nuclear receptor subfamily 4 group A member 1	Homo sapiens	5-10
27173006-0	2016	SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta1 via ROS/p38 MAPK/STAT3 pathway.	ros	93-96	signal transducer and activator of transcription 3	Homo sapiens	106-111
27173006-7	2016	Furthermore, the inhibitors for ROS (YCG063), p38 MAPK (SB203580), and STAT3 (Stattic) revealed ROS/p38 MAPK/STAT3 pathway involving in Egr-1 dependent activation of TGF-beta1 promoter induced by PLpro.	ros	32-35	signal transducer and activator of transcription 3	Homo sapiens	109-114
27173006-7	2016	Furthermore, the inhibitors for ROS (YCG063), p38 MAPK (SB203580), and STAT3 (Stattic) revealed ROS/p38 MAPK/STAT3 pathway involving in Egr-1 dependent activation of TGF-beta1 promoter induced by PLpro.	ros	32-35	transforming growth factor beta 1	Homo sapiens	166-175
27173006-7	2016	Furthermore, the inhibitors for ROS (YCG063), p38 MAPK (SB203580), and STAT3 (Stattic) revealed ROS/p38 MAPK/STAT3 pathway involving in Egr-1 dependent activation of TGF-beta1 promoter induced by PLpro.	ros	96-99	signal transducer and activator of transcription 3	Homo sapiens	71-76
27173006-7	2016	Furthermore, the inhibitors for ROS (YCG063), p38 MAPK (SB203580), and STAT3 (Stattic) revealed ROS/p38 MAPK/STAT3 pathway involving in Egr-1 dependent activation of TGF-beta1 promoter induced by PLpro.	ros	96-99	signal transducer and activator of transcription 3	Homo sapiens	109-114
27173006-7	2016	Furthermore, the inhibitors for ROS (YCG063), p38 MAPK (SB203580), and STAT3 (Stattic) revealed ROS/p38 MAPK/STAT3 pathway involving in Egr-1 dependent activation of TGF-beta1 promoter induced by PLpro.	ros	96-99	transforming growth factor beta 1	Homo sapiens	166-175
27173006-9	2016	The results revealed that SARS-CoV PLpro significantly triggered Egr-1 dependent activation of TGF-beta1 promoter via ROS/p38 MAPK/STAT3 pathway, correlating with up-regulation of pro-fibrotic responses in vitro and in vivo.	ros	118-121	signal transducer and activator of transcription 3	Homo sapiens	131-136
27166937-2	2016	Exposure of CD4(+) T cells to free linoleic acid causes their ROS-mediated depletion, thereby favoring liver cancer growth.	ros	62-65	CD4 molecule	Homo sapiens	12-15
27303747-3	2016	PI4P lipids serve to accumulate oxysterol-binding protein (OSBP), which subsequently transfers cholesterol to the ROs in a PI4P-dependent manner.	ros	114-117	oxysterol binding protein	Homo sapiens	32-57
27303747-3	2016	PI4P lipids serve to accumulate oxysterol-binding protein (OSBP), which subsequently transfers cholesterol to the ROs in a PI4P-dependent manner.	ros	114-117	oxysterol binding protein	Homo sapiens	59-63
27049917-0	2016	PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival.	ros	104-107	PDZ binding kinase	Homo sapiens	0-18
27029077-4	2016	In A549 instead of MRC-5 cells, genistein reduced the level of methylation in the Keap1 promoter region, leading to an increased mRNA expression, thus effectively inhibited the transcription of Nrf2 to the nucleus, which suppressed the Nrf2-dependent antioxidant and resulted in the upregulation of ROS.	ros	299-302	kelch like ECH associated protein 1	Homo sapiens	82-87
27029077-4	2016	In A549 instead of MRC-5 cells, genistein reduced the level of methylation in the Keap1 promoter region, leading to an increased mRNA expression, thus effectively inhibited the transcription of Nrf2 to the nucleus, which suppressed the Nrf2-dependent antioxidant and resulted in the upregulation of ROS.	ros	299-302	NFE2 like bZIP transcription factor 2	Homo sapiens	194-198
26872612-7	2016	PI3K/Akt pathway activation by iodide-induced ROS production is involved in the transcriptional repression of NIS expression.	ros	46-49	AKT serine/threonine kinase 1	Rattus norvegicus	5-8
27049917-0	2016	PDZ binding kinase (PBK) is a theranostic target for nasopharyngeal carcinoma: driving tumor growth via ROS signaling and correlating with patient survival.	ros	104-107	PDZ binding kinase	Homo sapiens	20-23
27049917-5	2016	Moreover, we determined that targeting PBK could accelerate apoptosis by inducing ROS that activates JNK/p38 signaling pathway.	ros	82-85	PDZ binding kinase	Homo sapiens	39-42
27049917-5	2016	Moreover, we determined that targeting PBK could accelerate apoptosis by inducing ROS that activates JNK/p38 signaling pathway.	ros	82-85	mitogen-activated protein kinase 14	Homo sapiens	105-108
27041464-1	2016	AIM: To investigate the effects of ROS scavenger N-acetylcysteine (NAC) on angiotensin II (Ang II)-mediated renal fibrosis in vivo and in vitro.	ros	35-38	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	75-89
26838071-3	2016	Recent evidence shows that the functional connections between cav-1 and ROS play a key role in many diseases.	ros	72-75	caveolin 1	Rattus norvegicus	62-67
27041464-1	2016	AIM: To investigate the effects of ROS scavenger N-acetylcysteine (NAC) on angiotensin II (Ang II)-mediated renal fibrosis in vivo and in vitro.	ros	35-38	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	91-97
26838071-10	2016	Furthermore, in HG-containing medium, the podocytes transfected with a recombinant plasmid GFP-cav-1 Y14F (mutation at a cav-1 phosphorylation site) exhibited significantly decreased ROS production and apoptosis compared with the cells transfected with empty vector.	ros	183-186	caveolin 1	Rattus norvegicus	95-100
26838071-10	2016	Furthermore, in HG-containing medium, the podocytes transfected with a recombinant plasmid GFP-cav-1 Y14F (mutation at a cav-1 phosphorylation site) exhibited significantly decreased ROS production and apoptosis compared with the cells transfected with empty vector.	ros	183-186	caveolin 1	Rattus norvegicus	121-126
27041464-8	2016	Furthermore, ROS production and the expression of p47 (a key subunit of NADPH oxidase complexes) were increased in a time-dependent manner; the expression of fibronectin, alpha-SMA and TGF-beta were upregulated.	ros	13-16	actin alpha 2, smooth muscle, aorta	Mus musculus	171-180
27041464-11	2016	Ang II also increased ROS production and the phosphorylation of Smad3.	ros	22-25	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
27041464-13	2016	CONCLUSION: In mouse obstructed kidneys, the fibrotic responses result from Ang II upregulation can be alleviated by the ROS scavenger N-acetylcysteine.	ros	121-124	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	76-82
26908090-9	2016	An increase in ROS paralleled the increase in TLR-2/4 and antioxidants treatment reduced TLR-2/4 expression and downstream inflammatory biomediators.	ros	15-18	toll like receptor 2	Homo sapiens	46-53
26914408-8	2016	Catalase-sensitive staining of cellular ROS with CellROX Deep Red was significantly increased in the presence of both 1 muM BK and 2 nM ET-1 but not either peptide alone.	ros	40-43	kininogen 1	Homo sapiens	124-126
26914408-8	2016	Catalase-sensitive staining of cellular ROS with CellROX Deep Red was significantly increased in the presence of both 1 muM BK and 2 nM ET-1 but not either peptide alone.	ros	40-43	endothelin 1	Homo sapiens	136-140
26445208-11	2016	These results indicate that Ang-II induces CF proliferation and migration in part via Nox4/ROS-dependent IL-18 induction and MMP9 activation, and may involve AT1/Nox4 physical association.	ros	91-94	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	28-34
26908090-9	2016	An increase in ROS paralleled the increase in TLR-2/4 and antioxidants treatment reduced TLR-2/4 expression and downstream inflammatory biomediators.	ros	15-18	toll like receptor 2	Homo sapiens	89-96
26908090-10	2016	CONCLUSION: Thus hyperglycemia induces HMAEC inflammation and glycocalyx dysfunction through TLR-2/4 pathway activation via increased ROS.	ros	134-137	toll like receptor 2	Homo sapiens	93-100
26866938-5	2016	Downregulation of Prx II in Huh7 cells with treatment of siRNA reduced expression of EpCAM and CD133 as well as Sox2 in accordance with increased ROS and apoptosis, which were reversed in Huh7-hPrx II cells.	ros	146-149	peroxiredoxin 2	Homo sapiens	18-24
26861955-4	2016	The statistically significant elevation of LDH levels, increased mitochondrial membrane potential, decreased ATP and increased ROS production, increased levels of DNA damage marker (8-OHdG) and activation of caspases: -3 and -9 confirmed by Real-Time PCR imply the activation of mitochondrial proapoptotic pathways induced by BZP after 24 h incubation.	ros	127-130	caspase 3	Homo sapiens	208-227
26946493-0	2016	Loss of IkappaB kinase beta promotes myofibroblast transformation and senescence through activation of the ROS-TGFbeta autocrine loop.	ros	107-110	transforming growth factor beta 1	Homo sapiens	111-118
26946493-6	2016	These data suggest that by blocking the autocrine amplification of a ROS-TGFbeta loop IKKbeta plays a crucial role in the prevention of fibroblast-myofibroblast transformation and senescence.	ros	69-72	transforming growth factor beta 1	Homo sapiens	73-80
26854718-8	2016	Further, inhibition of ROS with NAC not only rescued glioma cell necrosis but also suppressed JNK activation, mitigated Bax/Bcl-2 ratio, maintained mitochondrial membrane potential, and inhibited AIF translocation into nucleus.	ros	23-26	B cell leukemia/lymphoma 2	Mus musculus	124-129
27124120-2	2016	In the present study, we tested the hypothesis that CAV-1 improves dyslipidemia, inhibits cyclophilin A (CypA)- mediated ROS production, prevents mitochondrial compensatory action and attenuates oxidative stress responses in cholesterol-induced hypercholesterolemia.	ros	121-124	peptidyl-prolyl cis-trans isomerase A	Oryctolagus cuniculus	90-103
27124120-2	2016	In the present study, we tested the hypothesis that CAV-1 improves dyslipidemia, inhibits cyclophilin A (CypA)- mediated ROS production, prevents mitochondrial compensatory action and attenuates oxidative stress responses in cholesterol-induced hypercholesterolemia.	ros	121-124	peptidyl-prolyl cis-trans isomerase A	Oryctolagus cuniculus	105-109
27124120-8	2016	We concluded that CAV-1 plays a critical role in inhibiting CypA-mediated ROS production, improving dyslipidemia, maintaining mitochondrial function, and suppressing oxidative stress responses that are vital for cell survival in hypercholesterol-affected renal organs.	ros	74-77	peptidyl-prolyl cis-trans isomerase A	Oryctolagus cuniculus	60-64
26899267-7	2016	Data from several studies show that ROS generated in mitochondria under conditions of hypoxia stimulate HIF-1alpha.	ros	36-39	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
26992231-4	2016	Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells (HUVEC).	ros	121-124	NOP2/Sun RNA methyltransferase 2	Homo sapiens	65-70
26845448-6	2016	Pancreatic ductal adenocarcinoma (PDA) overexpressed VNN1 further aggravates paraneoplastic islet dysfunction; decreases in GSH/PPAR-gamma concentrations and increases in ROS/cysteamine might be primary cause of this effect.	ros	171-174	vanin 1	Homo sapiens	53-57
27015590-7	2016	Furthermore, YCF-2 ameliorated Abeta-induced neuronal cell death, ROS production, inflammatory factor release, and microglia activation by blocking the NF-kappaB signaling pathway in microglia.	ros	66-69	amyloid beta precursor protein	Homo sapiens	31-36
26985767-8	2016	High leukocyte mtDNA content significantly enhanced the ROS-mediated secretion of TGF-beta1, which accounted for higher Treg and lower NK frequency in PBMCs.	ros	56-59	transforming growth factor beta 1	Homo sapiens	82-91
26780704-6	2016	The inhibition of CAT activity induced by directly interacting with SDS was unable to catch the synthesis of CAT and therefore resulted in the increased activity and elevated ROS level.	ros	175-178	catalase	Mus musculus	18-21
26942697-0	2016	Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation.	ros	69-72	tumor protein p53	Homo sapiens	46-49
26942697-0	2016	Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation.	ros	69-72	AKT serine/threonine kinase 1	Homo sapiens	73-76
26942697-7	2016	Furthermore, ROS-induced activation of Akt was involved in PM2.5-induced increase in DNMT3B.	ros	13-16	AKT serine/threonine kinase 1	Homo sapiens	39-42
26942697-8	2016	In conclusion, our results strongly suggest that repeated exposure to PM2.5 induces epigenetic silencing of P53 through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation, which not only provides a possible explanation for PM-induced lung cancer, but also may help to identify specific interventions to prevent PM-induced lung carcinogenesis.	ros	120-123	tumor protein p53	Homo sapiens	108-111
26942697-8	2016	In conclusion, our results strongly suggest that repeated exposure to PM2.5 induces epigenetic silencing of P53 through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation, which not only provides a possible explanation for PM-induced lung cancer, but also may help to identify specific interventions to prevent PM-induced lung carcinogenesis.	ros	120-123	AKT serine/threonine kinase 1	Homo sapiens	124-127
26828685-2	2016	To overcome the issue, we designed new local protein delivery system by using a protein-loaded, redox-active, injectable gel (RIG), which is formed by a polyion complex (PIC) comprising three components, viz., cationic polyamine-poly(ethylene glycol)-polyamine triblock copolymer possessing ROS-scavenging moieties as side chains; anionic poly(acrylic acid); and a protein.	ros	291-294	DIRAS family, GTP-binding RAS-like 1	Mus musculus	126-129
26828685-5	2016	Subcutaneous injections of IL-12@RIG in the vicinity of tumor tissue showed remarkable tumor growth inhibition in tumor-bearing mice, compared to that observed with injection of IL-12 alone, suppressing adverse events caused by IL-12-induced ROS.	ros	242-245	DIRAS family, GTP-binding RAS-like 1	Mus musculus	27-36
26835555-9	2016	Moreover, JWH-015 induced the expression of p-PKB and p-FoxO1 protein and decreased the expression of cav-1, which were greatly reversed by ROS inhibitor or PI3K inhibitor.	ros	140-143	caveolin 1	Rattus norvegicus	102-107
26860957-7	2016	Pretreatment of antioxidants caused decrease in the levels of ROS/RNS leads to an increase in the levels of antioxidants, decrease in biomolecules damage, alterations in Akt, ERK1/2, tuberin, upregulation of OGG1, and decrease in 8-OHdG accumulations in DNA.	ros	62-65	thymoma viral proto-oncogene 1	Mus musculus	170-173
26794444-0	2016	HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3.	ros	12-15	snail family transcriptional repressor 1	Homo sapiens	67-72
26794444-4	2016	Here, we showed that the repression of SOCS3 and sustained activation of IL-6/STAT3 pathway in HBV-producing HCC cells were caused by HBV-induced mitochondrial ROS accumulation.	ros	160-163	interleukin 6	Homo sapiens	73-77
26794444-4	2016	Here, we showed that the repression of SOCS3 and sustained activation of IL-6/STAT3 pathway in HBV-producing HCC cells were caused by HBV-induced mitochondrial ROS accumulation.	ros	160-163	signal transducer and activator of transcription 3	Homo sapiens	78-83
26794444-7	2016	Further studies revealed that HBV-induced ROS accumulation upregulated the expression of the transcription factor, Snail, which bound to the E-boxes of SOCS3 promoter and mediated the epigenetic silencing of SOCS3 in association with DNMT1 and HDAC1.	ros	42-45	snail family transcriptional repressor 1	Homo sapiens	115-120
26794444-9	2016	Taken together, our data show that HBV-induced mitochondrial ROS production represses SOCS3 expression through Snail-mediated epigenetic silencing, leading to the sustained activation of IL-6/STAT3 pathway and ultimately contributing to hepatocarcinogenesis.	ros	61-64	snail family transcriptional repressor 1	Homo sapiens	111-116
26794444-9	2016	Taken together, our data show that HBV-induced mitochondrial ROS production represses SOCS3 expression through Snail-mediated epigenetic silencing, leading to the sustained activation of IL-6/STAT3 pathway and ultimately contributing to hepatocarcinogenesis.	ros	61-64	interleukin 6	Homo sapiens	187-191
26794444-9	2016	Taken together, our data show that HBV-induced mitochondrial ROS production represses SOCS3 expression through Snail-mediated epigenetic silencing, leading to the sustained activation of IL-6/STAT3 pathway and ultimately contributing to hepatocarcinogenesis.	ros	61-64	signal transducer and activator of transcription 3	Homo sapiens	192-197
26860957-5	2016	The increase in levels of inflammatory cytokines/chemokines corresponds to increased levels of ROS/RNS, which is accompanied by increased activities of Akt, ERK1/2, tuberin, down regulation of 8-oxoG-DNA glycosylase (OGG1), and increase in 8-hydroxydeoxyguanosine (8-OHdG) accumulation in DNA.	ros	95-98	thymoma viral proto-oncogene 1	Mus musculus	152-155
26548866-10	2016	Downregulation of FoxO1 markedly increased ROS level, as reflected by increased DHE staining.	ros	43-46	forkhead box O1	Homo sapiens	18-23
26335302-5	2016	RESULTS: Vit.D reduced IR-induced ROS production protecting proliferating and quiescent HUVEC from cellular apoptosis or senescence, respectively, by regulating MAPKs pathways.	ros	34-37	vitrin	Homo sapiens	9-12
26936198-0	2016	Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway.	ros	102-105	mitogen-activated protein kinase 14	Homo sapiens	115-118
27000859-9	2016	The phosphorylation of ERK and P38 were not attenuated by the addition of NAC, but the use of the p38 inhibitor could reduce, at least in part, PA-induced ROS and the proportion of cells in G2/M.	ros	155-158	mitogen-activated protein kinase 14	Homo sapiens	98-101
27000859-10	2016	PA induces G2/M cell cycle arrest in A549 cells involving in the p38 MAPK/ROS pathway.	ros	74-77	mitogen-activated protein kinase 14	Homo sapiens	65-68
26548866-13	2016	Our findings highlight miR-155/FoxO1/ROS axis as a novel therapeutic target for the inhibition of NSCLC growth.	ros	37-40	forkhead box O1	Homo sapiens	31-36
26975474-7	2016	We conclude that the mitochondrial thioredoxin system controls the redox state of cyclophilin D which, in turn, may act as a regulator of several processes including ROS production and pro-apoptotic factors release.	ros	166-169	thioredoxin 1	Rattus norvegicus	35-46
27065868-0	2016	Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-kappaB Cascade on Human Pulmonary Alveolar Epithelial Cells.	ros	68-71	nuclear factor kappa B subunit 1	Homo sapiens	82-91
27004848-8	2016	Scavenging ROS, inhibiting NADPH oxidase or knockdown of NOX2 abolished the effects of salusin-beta on ACAT-1 and VCAM-1 expressions, p65-NFkappaB nuclear translocation, lipid accumulation and monocyte adhesion in VSMCs.	ros	11-14	torsin family 2 member A	Homo sapiens	87-99
26573462-4	2016	RESULTS: We found that monocyte chemoattractant protein-1 (MCP-1) was secreted as a dominant component of the SASP during expansion of UCB-MSCs and reinforced senescence via its cognate receptor chemokine (c-c motif) receptor 2 (CCR2) by activating the ROS-p38-MAPK-p53/p21 signaling cascade in both an autocrine and paracrine manner.	ros	253-256	C-C motif chemokine receptor 2	Homo sapiens	195-227
26739061-3	2016	In the present study, exposure of MCF-7 breast cancer cells to HIS and the H1 receptor antagonist AST both alone and together with HIS (AST-HIS) led to generation of intracellular ROS, which induced massive cellular vacuolization through dilation of the ER and mitochondria.	ros	180-183	solute carrier family 17 member 5	Homo sapiens	98-101
26869514-0	2016	Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation.	ros	100-103	transferrin	Homo sapiens	0-11
26739061-3	2016	In the present study, exposure of MCF-7 breast cancer cells to HIS and the H1 receptor antagonist AST both alone and together with HIS (AST-HIS) led to generation of intracellular ROS, which induced massive cellular vacuolization through dilation of the ER and mitochondria.	ros	180-183	solute carrier family 17 member 5	Homo sapiens	136-139
26739061-8	2016	In conclusion, these findings indicate that AST-HIS-induced apoptosis and autophagy can be regulated by ROS-mediated signaling pathways.	ros	104-107	solute carrier family 17 member 5	Homo sapiens	44-47
26895301-2	2016	In several cell types, ROS can trigger an antioxidant cell response through the transcriptional induction of oxidative stress-responsive genes regulated by the nuclear factor erythroid 2-related factor 2 (Nrf2).	ros	23-26	NFE2 like bZIP transcription factor 2	Homo sapiens	160-203
26468015-0	2016	ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic effect of ajoene on cells of lung adenocarcinoma.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	27-30
26468015-0	2016	ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic effect of ajoene on cells of lung adenocarcinoma.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	31-34
26468015-11	2016	Our results suggest that ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic action of ajoene on cells of lung adenocarcinoma.	ros	25-28	mitogen-activated protein kinase 8	Homo sapiens	52-55
26468015-11	2016	Our results suggest that ROS-mediated activation of JNK/p38 contributes partially to the pro-apoptotic action of ajoene on cells of lung adenocarcinoma.	ros	25-28	mitogen-activated protein kinase 14	Homo sapiens	56-59
27019635-2	2016	Here we review the current knowledge of mitochondrial Stat3 as a regulator of the electron transport chain (ETC) and its impact on mitochondrial production of ATP and ROS.	ros	167-170	signal transducer and activator of transcription 3	Homo sapiens	54-59
26791102-5	2016	miR-214 expression was transcriptionally repressed by Nrf2 through a canonical antioxidant response element (ARE) within its promoter region, and this repression is ROS-dependence.	ros	165-168	microRNA 214	Homo sapiens	0-7
26791102-5	2016	miR-214 expression was transcriptionally repressed by Nrf2 through a canonical antioxidant response element (ARE) within its promoter region, and this repression is ROS-dependence.	ros	165-168	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
26775629-5	2016	Using BCC/KMC1 cell line as a model, the upstream signaling of p53 activation was dissected by over-expression of TLR7/8, the addition of ROS scavenger, ATM/ATR inhibitors and pan-caspase inhibitor.	ros	138-141	tumor protein p53	Homo sapiens	63-66
26775629-8	2016	In BCC/KMC1 cells, the induction of p53 by IMQ was achieved through increased ROS production to stimulate the ATM/ATR-Chk1/Chk2 axis but was not mediated by inducing DNA damage.	ros	78-81	tumor protein p53	Homo sapiens	36-39
26775629-8	2016	In BCC/KMC1 cells, the induction of p53 by IMQ was achieved through increased ROS production to stimulate the ATM/ATR-Chk1/Chk2 axis but was not mediated by inducing DNA damage.	ros	78-81	ATR serine/threonine kinase	Homo sapiens	114-117
26775629-8	2016	In BCC/KMC1 cells, the induction of p53 by IMQ was achieved through increased ROS production to stimulate the ATM/ATR-Chk1/Chk2 axis but was not mediated by inducing DNA damage.	ros	78-81	checkpoint kinase 1	Homo sapiens	118-122
26895301-2	2016	In several cell types, ROS can trigger an antioxidant cell response through the transcriptional induction of oxidative stress-responsive genes regulated by the nuclear factor erythroid 2-related factor 2 (Nrf2).	ros	23-26	NFE2 like bZIP transcription factor 2	Homo sapiens	205-209
26889377-13	2016	Depletion of UMSBP (LdU(-/-)) caused kDNA loss, which decreased cytochrome-b expression [component of complex-III of electron transport chain (ETC)] and leads to the disruption of complex-III activity, decreased ATP generation, increased ROS level and promastigotes exhibited apoptosis like death.	ros	238-241	universal minicircle sequence binding protein	Leishmania donovani	13-18
26730840-3	2016	ROS trigger TGF-beta pathway that activates cardiac fibroblasts promoting fibrosis.	ros	0-3	transforming growth factor, beta 1	Rattus norvegicus	12-20
26863027-4	2016	Experiments to determine the phenotypes resulting from the loss of SSK1 reveal that the SSK1 gene product may be fulfilling similar regulatory roles in signaling pathways involving a HOG1 MAP kinase during ROS resistance, osmotic resistance, fungicide sensitivity and fungal virulence.	ros	206-209	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	67-71
26863027-4	2016	Experiments to determine the phenotypes resulting from the loss of SSK1 reveal that the SSK1 gene product may be fulfilling similar regulatory roles in signaling pathways involving a HOG1 MAP kinase during ROS resistance, osmotic resistance, fungicide sensitivity and fungal virulence.	ros	206-209	mitogen-activated protein kinase kinase kinase SSK1	Saccharomyces cerevisiae S288C	88-92
26804764-0	2016	4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.	ros	89-92	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
29931867-11	2016	(4) The level of Nrf2 in serum was positively correlated with ROS and -dP/dtmin, and negatively correlated with HR, Ea.	ros	62-65	NFE2 like bZIP transcription factor 2	Rattus norvegicus	17-21
27047320-10	2016	MPF8 was assayed for in-vitro cytotoxicity by MTT assay which confirms its less cytotoxicity at lower concentration and also significant ROS determination against J774 and THP1 cell lines after 2 and 4 hours.	ros	137-140	GLI family zinc finger 2	Homo sapiens	172-176
26804764-11	2016	Collectively, our findings provide the first evidence that NP promotes apoptosis, autophagy and necrosis simultaneously in SCs and that this process may involve ROS-dependent JNK- and Akt/AMPK/mTOR pathways.	ros	161-164	AKT serine/threonine kinase 1	Rattus norvegicus	184-187
26637556-0	2016	Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.	ros	109-112	angiotensin II receptor, type 1a	Mus musculus	19-22
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	ros	130-133	mitogen-activated protein kinase 1	Homo sapiens	64-67
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	ros	130-133	mitogen-activated protein kinase 3	Homo sapiens	68-72
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	ros	130-133	mitogen-activated protein kinase 8	Homo sapiens	73-76
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	ros	130-133	mitogen-activated protein kinase 1	Homo sapiens	148-151
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	ros	130-133	mitogen-activated protein kinase 3	Homo sapiens	152-156
26716417-7	2016	Pretreatment of cells with the thiol antioxidant glutathione or p38 MAPK/JNK inhibitors before Cd treatment effectively abrogated ROS activation of p38 MAPK/JNK pathways and apoptosis-related proteins.	ros	130-133	mitogen-activated protein kinase 8	Homo sapiens	157-160
26637556-8	2016	The microglial inhibitor minocycline attenuated ANG II-mediated ROS production, yet ANG II effects persisted in PVN single-minded 1-AT1a knockout mice, supporting the contribution of a non-neuronal source (likely microglia) to ANG II-driven ROS production in the PVN.	ros	64-67	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	48-54
26612416-8	2016	Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways.	ros	105-108	BCL2 apoptosis regulator	Homo sapiens	149-154
26612416-8	2016	Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways.	ros	105-108	BCL2 associated X, apoptosis regulator	Homo sapiens	155-158
26612416-8	2016	Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways.	ros	105-108	caspase 3	Homo sapiens	174-183
26612416-8	2016	Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways.	ros	105-108	AKT serine/threonine kinase 1	Homo sapiens	190-193
26612416-8	2016	Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways.	ros	105-108	mechanistic target of rapamycin kinase	Homo sapiens	194-198
26612416-8	2016	Moreover, Se@LDH-pooled siRNAs could induce cell apoptosis, change cell morphology and increase cellular ROS levels through change the expression of Bcl-2/Bax, activation of caspase-3, PI3K/AKT/mTOR and MAPK/ERK pathways.	ros	105-108	mitogen-activated protein kinase 1	Homo sapiens	208-211
26637556-0	2016	Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.	ros	109-112	toll-like receptor 4	Mus musculus	37-57
26637556-7	2016	ANG II increased ROS production, as indicated by dihydroethidium fluorescence, within the PVN of rats and mice (P &lt; 0.0001 in both cases), effects that were also dependent on the presence of functional TLR4.	ros	17-20	angiotensinogen	Rattus norvegicus	0-6
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	ros	56-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	ros	56-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	ros	177-180	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	ros	177-180	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
25560767-5	2016	KEY RESULTS: C21 attenuated TNFalpha-induced: monocyte adhesion to cultured HUVECs, adhesion molecule expression and abolished TNFalpha-induced ROS production.	ros	144-147	tumor necrosis factor	Mus musculus	28-36
25560767-5	2016	KEY RESULTS: C21 attenuated TNFalpha-induced: monocyte adhesion to cultured HUVECs, adhesion molecule expression and abolished TNFalpha-induced ROS production.	ros	144-147	tumor necrosis factor	Mus musculus	127-135
26707081-4	2016	By inhibiting mTOR and mitochondrial manganese superoxide dismutase (MnSOD), we confirmed that rapamycin functioned through the mTOR/MnSOD/reactive oxygen species (ROS) signaling pathway, and the existence of Akt governed the rapamycin-induced asymmetric division (AD) of stem cells in cases of radiation-treated breast cancer.	ros	164-167	mechanistic target of rapamycin kinase	Homo sapiens	14-18
26687534-0	2016	P21(Waf1/Cip1) plays a critical role in furazolidone-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.	ros	135-138	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-13
26566260-13	2016	Cytokine secretion was also regulated by ROS, which were attenuated by TMZ via activation of Sirt1, AMPK and PPARalpha.	ros	41-44	peroxisome proliferator activated receptor alpha	Mus musculus	109-118
26687534-7	2016	Overexpression of p21 attenuated FZD-induced caspase-3 activation and ROS generation, eventually reduced apoptosis.	ros	70-73	cyclin dependent kinase inhibitor 1A	Homo sapiens	18-21
26687534-9	2016	In addition, the influence of p21 on FZD-induced ROS generation might be associated with Nrf2/HO-1 pathway which was a key regulator in defense response against oxidative stress.	ros	49-52	cyclin dependent kinase inhibitor 1A	Homo sapiens	30-33
26687534-9	2016	In addition, the influence of p21 on FZD-induced ROS generation might be associated with Nrf2/HO-1 pathway which was a key regulator in defense response against oxidative stress.	ros	49-52	NFE2 like bZIP transcription factor 2	Homo sapiens	89-93
26687534-10	2016	In conclusion, these findings demonstrated that p21 plays a critical role in FZD-induced apoptosis in HepG2 cells through influencing the caspase-3 activation and ROS generation.	ros	163-166	cyclin dependent kinase inhibitor 1A	Homo sapiens	48-51
26689473-3	2016	We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production.	ros	153-156	mitogen-activated protein kinase kinase 7	Homo sapiens	178-181
26689473-3	2016	We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production.	ros	153-156	mitogen-activated protein kinase 1	Homo sapiens	182-185
26689473-3	2016	We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production.	ros	153-156	AKT serine/threonine kinase 1	Homo sapiens	191-194
26689473-3	2016	We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production.	ros	260-263	mitogen-activated protein kinase kinase 7	Homo sapiens	178-181
26689473-3	2016	We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production.	ros	260-263	mitogen-activated protein kinase 1	Homo sapiens	182-185
26689473-3	2016	We recently showed that relatively low concentrations of 27-OH generated a strong survival signaling through an early and transient increase of cellular ROS level, that enhanced MEK-ERK/PI3K-Akt phosphorylation, in turn responsible of a sustained quenching of ROS production.	ros	260-263	AKT serine/threonine kinase 1	Homo sapiens	191-194
26689473-4	2016	It remains to identify the link between ERK/Akt up-regulation and the consequent quenching effect on ROS intracellular level that efficiently and markedly delay the pro-apoptotic effect of the oxysterol.	ros	101-104	mitogen-activated protein kinase 1	Homo sapiens	40-43
26689473-4	2016	It remains to identify the link between ERK/Akt up-regulation and the consequent quenching effect on ROS intracellular level that efficiently and markedly delay the pro-apoptotic effect of the oxysterol.	ros	101-104	AKT serine/threonine kinase 1	Homo sapiens	44-47
26707081-6	2016	Governed by Akt, the consequent inhibition of ROS formation and oxidative stress preserved the AD mode of stem cells, which is critical for an improved radiotherapy response in clinical treatment, as the tumor group is thus easier to eliminate with radiation therapy.	ros	46-49	AKT serine/threonine kinase 1	Homo sapiens	12-15
26707143-0	2016	Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells.	ros	72-75	mitogen-activated protein kinase 8	Homo sapiens	81-84
26177712-5	2016	ROS production increases in cells treated with BSO or TNFalpha, and this has been related to an up-regulation of ICAM-1 expression and sICAM-1 release.	ros	0-3	tumor necrosis factor	Homo sapiens	54-62
26718128-6	2016	Taken together, our results indicated that hispolon suppressed the migration of breast cancer cells via suppressing the ROS/ERK/Slug/E-cadherin pathway.	ros	120-123	mitogen-activated protein kinase 1	Homo sapiens	124-127
26718128-6	2016	Taken together, our results indicated that hispolon suppressed the migration of breast cancer cells via suppressing the ROS/ERK/Slug/E-cadherin pathway.	ros	120-123	cadherin 1	Homo sapiens	133-143
26725009-5	2016	In contrast, genetic reconstitution of the mitochondrial membrane potential restored ROS, which were necessary for hypoxic activation of HIF-1 and cell proliferation.	ros	85-88	hypoxia inducible factor 1 subunit alpha	Homo sapiens	137-142
26790152-6	2016	Furthermore, the levels of ROS in the colon were increased significantly, whereas the expression levels of antioxidative genes were down-regulated dramatically in the colon of Cyp27b1(-/-)mice.	ros	27-30	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	176-183
26740011-7	2016	Moreover, oncogenic H-ras(V12) does not trigger aerobic glycolysis in antioxidant-treated or PHD2 knocked-down cells, suggesting the participation of the ROS-mediated PHD2 inactivation in the oncogenic H-ras(V12)-mediated metabolic reprogramming.	ros	154-157	egl-9 family hypoxia inducible factor 1	Homo sapiens	167-171
26625314-5	2016	The corrective effects of PPARgamma ligand on lal-/- MDSCs functions were mediated by regulating the mammalian target of rapamycin (mTOR) pathway, and subsequently blocking MDSCs ROS overproduction.	ros	179-182	peroxisome proliferator activated receptor gamma	Homo sapiens	26-35
26789270-12	2016	CONCLUSION: In conclusion, this study demonstrated, for the first time, that Tbeta4 was down-regulated in ROS-stimulated PDLCs as well as Tbeta4 activation exhibited anti-inflammatory effects and anti-osteoclastogenesis in vitro.	ros	106-109	thymosin beta 4 X-linked	Homo sapiens	77-83
27310130-6	2016	In addition, exposing cells to MF increased the level of mitochondrial ROS which were released into cytoplasm through mitochondrial permeability transition pores (mPTP), and induced ROS-dependent phosphorylation of Akt.	ros	182-185	AKT serine/threonine kinase 1	Homo sapiens	215-218
28959532-7	2016	We hypothesize that Mel may be scavenging reactive species of oxygen (ROS) that could be damaging lipids, PEPCK, G6Pase and ferrochelatase (FQ).	ros	70-73	ferrochelatase	Rattus norvegicus	124-138
26513353-8	2016	TGF-beta promoted CF proliferation, collagen secretion, ROS production and Nox2/Nox4 expression, which was inhibited by EPO.	ros	56-59	transforming growth factor, beta 1	Rattus norvegicus	0-8
27010918-0	2016	Heat Killed Attenuated Leishmania Induces Apoptosis of HepG2 Cells Through ROS Mediated p53 Dependent Mitochondrial Pathway.	ros	75-78	tumor protein p53	Homo sapiens	88-91
27010918-11	2016	In conclusion, Leishmania donovani UR6 efficiently induces apoptosis in HepG2 cells through ROS mediated p53 dependent mitochondrial pathway.	ros	92-95	tumor protein p53	Homo sapiens	105-108
27010918-13	2016	From our study we found that Leishmania donovani UR6 efficiently induced apoptosis in HepG2 cells through ROS mediated p53 dependent mitochondrial pathway.	ros	106-109	tumor protein p53	Homo sapiens	119-122
27563337-3	2016	IRE1-JNK and eIF2alpha-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors.	ros	118-121	mitogen-activated protein kinase 8	Homo sapiens	5-8
26507802-4	2016	H-RuBmp demonstrated a higher interaction potency with the cell membrane and induced higher levels of ROS overproduction in cancer cells to regulate the AKT, MAPK, and p53 signaling pathways.	ros	102-105	AKT serine/threonine kinase 1	Homo sapiens	153-156
26507802-4	2016	H-RuBmp demonstrated a higher interaction potency with the cell membrane and induced higher levels of ROS overproduction in cancer cells to regulate the AKT, MAPK, and p53 signaling pathways.	ros	102-105	tumor protein p53	Homo sapiens	168-171
27366195-8	2016	SMT suppressed NF-kappaB translocation and activation as well as expression of CAMs, monocyte adhesion, and ROS production induced by TNF-alpha in HUVECs.	ros	108-111	tumor necrosis factor	Homo sapiens	134-143
27563337-3	2016	IRE1-JNK and eIF2alpha-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors.	ros	118-121	DNA damage inducible transcript 3	Homo sapiens	23-27
26480821-9	2016	A probable link between down-regulation of HIF-1alpha with reduction of ROS by PEITC through induction of Nrf2 was determined.	ros	72-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	43-53
26515689-8	2016	Moreover, Abeta also reduced sirtuin 1 (Sirt1) and its downstream signaling, resulting in increased intracellular ROS accumulation and mitochondrial dysfunction.	ros	114-117	amyloid beta precursor protein	Homo sapiens	10-15
26480821-9	2016	A probable link between down-regulation of HIF-1alpha with reduction of ROS by PEITC through induction of Nrf2 was determined.	ros	72-75	NFE2 like bZIP transcription factor 2	Homo sapiens	106-110
27050175-2	2016	It is based on evidence that a continuous long-term exposure to oral bacteremia and bacterial toxins induces inflammatory immune response after immune evasion releases growth factors such as FGF, EGF, TGF-Beta, free radicals such as ROS and NOS, cytokines such as TNFAlfa, IL-1 Beta, IL-6; and matrix metalloproteinase such as MMP-9.	ros	233-236	interleukin 1 beta	Homo sapiens	273-282
27050175-2	2016	It is based on evidence that a continuous long-term exposure to oral bacteremia and bacterial toxins induces inflammatory immune response after immune evasion releases growth factors such as FGF, EGF, TGF-Beta, free radicals such as ROS and NOS, cytokines such as TNFAlfa, IL-1 Beta, IL-6; and matrix metalloproteinase such as MMP-9.	ros	233-236	interleukin 6	Homo sapiens	284-288
26111538-6	2016	Coincidently, both superoxide formation and ERK1/2 phosphorylation were observed in Met-5A cells exposed to MWCNTs and were diminished by pretreatment with the reactive oxidative species (ROS) scavenger, N-acetyl-l-(+)-cysteine (NAC).	ros	188-191	mitogen-activated protein kinase 3	Homo sapiens	44-50
26884717-12	2016	Taken together, these suggested that CsA could suppress ROS-mediated p53 mitochondrial distribution and cell apoptosis depended on its inhibition effect to mitochondrial permeability transition.	ros	56-59	tumor protein p53	Homo sapiens	69-72
26511233-8	2016	This leads to the activation of calcineurin B, independent of NFAT involvement, which in coordination with ROS induces the activation of JNK of the MAPK signalling.	ros	107-110	mitogen-activated protein kinase 8	Homo sapiens	137-140
26619119-5	2016	SLAMF1 ligation with an agonistic monoclonal antibody increased ROS accumulation and induced phosphorylation of p38, JNK1/2, and BCL2, thereby promoting the autophagic flux.	ros	64-67	signaling lymphocytic activation molecule family member 1	Homo sapiens	0-6
26981120-4	2016	Luminal A subtype MCF7 (ER(+), PR(+), HER2(-)) cells maintained the highest intracellular ROS level and were subjected to TCBQ-induced ROS reduction, apoptosis, and cytotoxicity.	ros	90-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-42
26981120-4	2016	Luminal A subtype MCF7 (ER(+), PR(+), HER2(-)) cells maintained the highest intracellular ROS level and were subjected to TCBQ-induced ROS reduction, apoptosis, and cytotoxicity.	ros	135-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-42
26981120-5	2016	HER2 subtype Sk-Br-3 (ER(-), PR(-), HER2(+)) cells possessed the lowest intracellular ROS level.	ros	86-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
26981120-5	2016	HER2 subtype Sk-Br-3 (ER(-), PR(-), HER2(+)) cells possessed the lowest intracellular ROS level.	ros	86-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-40
27433030-6	2016	These findings suggest that XO may be a potential target of HSYA via direct binding inhibition and the combination of HSYA-XO suppresses LPS-induced ROS generation, contributing to the depression of NLRP3 inflammasome and inhibition of IL-1beta secretion in macrophages.	ros	149-152	interleukin 1 beta	Mus musculus	236-244
26096299-9	2016	Stimulation with TNF-alpha triggers ROS generation and activates a number of key intracellular signaling mediators known to positively regulate angiogenesis (Akt, small GTPase Rac1, ERK1/2, and p38 MAP-kinases).	ros	36-39	tumor necrosis factor	Mus musculus	17-26
26682007-8	2016	Most importantly, the inactivation of Foxo3a induced by JC further led to an increase of intracellular ROS levels by suppressing ROS scavenging enzymes, and the antioxidant N-acetyl-L-cysteine and catalase successfully decreased JC-induced apoptosis.	ros	103-106	forkhead box O3	Homo sapiens	38-44
26682007-8	2016	Most importantly, the inactivation of Foxo3a induced by JC further led to an increase of intracellular ROS levels by suppressing ROS scavenging enzymes, and the antioxidant N-acetyl-L-cysteine and catalase successfully decreased JC-induced apoptosis.	ros	129-132	forkhead box O3	Homo sapiens	38-44
26788244-8	2016	CONCLUSION: These findings reveal that O-Tyr may induce oxidative damage and hepatic fibrosis via MAPK/TGF-beta1 signaling pathway, in which ROS together with malondialdehyde (MDA) and OPPs act as the pivotal mediators.	ros	141-144	transforming growth factor, beta 1	Rattus norvegicus	103-112
26989455-7	2016	Thus, a ROS-dependent epigenetic positive regulation of Sod2 gene expression likely represents a defense mechanism prolonging eNOS function in aging mouse femoral arteries.	ros	8-11	superoxide dismutase 2, mitochondrial	Mus musculus	56-60
26823953-7	2016	Data from fluorescence microscopy illustrated that increased intracellular ROS production upon TNF-alpha-stimulation was remarkably inhibited by HE pretreatment in a dose-dependent manner.	ros	75-78	tumor necrosis factor	Homo sapiens	95-104
27525052-6	2016	In addition, we observed that MeHg induced ROS production in a dose-dependent manner in hNPCs cells, which was associated with significantly increased expressions of ND1, Cytb, and ATP6.	ros	43-46	mitochondrially encoded NADH dehydrogenase 1	Homo sapiens	166-169
27547294-6	2016	Furthermore, we observed that knockdown of CD38 remarkably inhibited ROS generation and intracellular Ca(2+) overloading induced by H/R in H9c2 cells.	ros	69-72	CD38 molecule	Rattus norvegicus	43-47
26632198-0	2015	EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway.	ros	69-72	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
27703600-5	2016	Our results indicate that CH not only is a structural component of cell membrane but also functionally contributes to regulating cellular senescence by modulating cell cycle, autophagy, and the ROS/p53/p21Cip1/Waf1 signaling pathway.	ros	194-197	cyclin dependent kinase inhibitor 1A	Homo sapiens	210-214
29227594-3	2016	Our previousstudies revealed that ROS production by human colorectal adenocarcinoma HT-29 cells is positively correlatedwith adaptor protein Ruk/CIN85 expression while increased levels of Ruk/CIN85 in weakly invasive humanbreast adenocarcinoma MC F-7 cells contribute to their malignant phenotype through the constitutiveactivation of Src/Akt pathway.	ros	34-37	SH3 domain containing kinase binding protein 1	Homo sapiens	145-150
29227594-3	2016	Our previousstudies revealed that ROS production by human colorectal adenocarcinoma HT-29 cells is positively correlatedwith adaptor protein Ruk/CIN85 expression while increased levels of Ruk/CIN85 in weakly invasive humanbreast adenocarcinoma MC F-7 cells contribute to their malignant phenotype through the constitutiveactivation of Src/Akt pathway.	ros	34-37	SH3 domain containing kinase binding protein 1	Homo sapiens	192-197
29227594-3	2016	Our previousstudies revealed that ROS production by human colorectal adenocarcinoma HT-29 cells is positively correlatedwith adaptor protein Ruk/CIN85 expression while increased levels of Ruk/CIN85 in weakly invasive humanbreast adenocarcinoma MC F-7 cells contribute to their malignant phenotype through the constitutiveactivation of Src/Akt pathway.	ros	34-37	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	335-338
29227594-3	2016	Our previousstudies revealed that ROS production by human colorectal adenocarcinoma HT-29 cells is positively correlatedwith adaptor protein Ruk/CIN85 expression while increased levels of Ruk/CIN85 in weakly invasive humanbreast adenocarcinoma MC F-7 cells contribute to their malignant phenotype through the constitutiveactivation of Src/Akt pathway.	ros	34-37	AKT serine/threonine kinase 1	Homo sapiens	339-342
26632198-6	2015	Our study reveals that novel mechanisms allow Tat-induced HIV-1 transactivation by ROS/Akt-dependent downregulating the EZH2 epigenetic silencing machinery.	ros	83-86	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	120-124
27703600-5	2016	Our results indicate that CH not only is a structural component of cell membrane but also functionally contributes to regulating cellular senescence by modulating cell cycle, autophagy, and the ROS/p53/p21Cip1/Waf1 signaling pathway.	ros	194-197	tumor protein p53	Homo sapiens	198-201
27703600-5	2016	Our results indicate that CH not only is a structural component of cell membrane but also functionally contributes to regulating cellular senescence by modulating cell cycle, autophagy, and the ROS/p53/p21Cip1/Waf1 signaling pathway.	ros	194-197	cyclin dependent kinase inhibitor 1A	Homo sapiens	202-209
27891207-8	2016	These results reveal that GAS has the cytoprotection in HepG2 cells during ROS exposure by inhibiting the caspase activity in the mitochondria and influencing apoptogenic factors of the expression of Bax and Bcl-2.	ros	75-78	BCL2 associated X, apoptosis regulator	Homo sapiens	200-203
27467924-0	2016	TLR4/IFNgamma pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models.	ros	75-78	toll-like receptor 4	Mus musculus	0-4
27467924-0	2016	TLR4/IFNgamma pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models.	ros	75-78	interferon gamma	Mus musculus	5-13
27467924-0	2016	TLR4/IFNgamma pathways induce tumor regression via NOS II-dependent NO and ROS production in murine breast cancer models.	ros	75-78	nitric oxide synthase 2, inducible	Mus musculus	51-57
26632198-6	2015	Our study reveals that novel mechanisms allow Tat-induced HIV-1 transactivation by ROS/Akt-dependent downregulating the EZH2 epigenetic silencing machinery.	ros	83-86	AKT serine/threonine kinase 1	Homo sapiens	87-90
26632198-0	2015	EZH2 phosphorylation regulates Tat-induced HIV-1 transactivation via ROS/Akt signaling pathway.	ros	69-72	AKT serine/threonine kinase 1	Homo sapiens	73-76
26632198-5	2015	ROS/Akt-dependent p-EZH2 was correlated with Tat-induced transactivation.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	4-7
26632198-5	2015	ROS/Akt-dependent p-EZH2 was correlated with Tat-induced transactivation.	ros	0-3	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	20-24
26862579-3	2016	Ang II-induced VSMC ROS production is modulated by alpha1beta1 integrin.	ros	20-23	angiotensinogen	Homo sapiens	0-6
26862579-4	2016	Ang II also stimulates ROS production in VSMC via p47 (phox) , a NOX2 subunit.	ros	23-26	angiotensinogen	Homo sapiens	0-6
26862579-7	2016	Ang II effect on ROS production is also PI3K dependent.	ros	17-20	angiotensinogen	Homo sapiens	0-6
26575622-7	2015	Finally, mechanistic experiments performed on isolated mouse muscles exposed to HIIT-mimicking stimulation showed reactive oxygen/nitrogen species (ROS)-dependent RyR1 fragmentation, calpain activation, increased SR Ca(2+) leak at rest, and depressed force production due to impaired SR Ca(2+) release upon stimulation.	ros	148-151	ryanodine receptor 1, skeletal muscle	Mus musculus	163-167
26575622-8	2015	In conclusion, HIIT exercise induces a ROS-dependent RyR1 fragmentation in muscles of recreationally active subjects, and the resulting changes in muscle fiber Ca(2+)-handling trigger muscular adaptations.	ros	39-42	ryanodine receptor 1	Homo sapiens	53-57
26659006-6	2015	UCP2-ROS signaling may be involved in inflammasome suppression by genipin.	ros	5-8	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	0-4
26640170-1	2015	Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury.	ros	89-92	coagulation factor II	Mus musculus	0-8
26465677-0	2015	A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway.	ros	108-111	mitogen-activated protein kinase 1	Homo sapiens	112-115
26465677-0	2015	A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway.	ros	108-111	AKT serine/threonine kinase 1	Homo sapiens	116-119
26642060-9	2015	Addition of MnTMPyP, a ROS scavenger, reduced HG-induced ROS production and accelerated cell migration, suggesting that the influence of HG on bFGF-MAPK signaling causes accumulation of ROS, which in turn regulate cell migration.	ros	57-60	mitogen-activated protein kinase 1	Homo sapiens	148-152
26465677-0	2015	A Novel Platinum-Maurocalcine Conjugate Induces Apoptosis of Human Glioblastoma Cells by Acting through the ROS-ERK/AKT-p53 Pathway.	ros	108-111	tumor protein p53	Homo sapiens	120-123
26642060-0	2015	bFGF-Regulating MAPKs Are Involved in High Glucose-Mediated ROS Production and Delay of Vascular Endothelial Cell Migration.	ros	60-63	fibroblast growth factor 2	Homo sapiens	0-4
26642060-8	2015	Molecular and cell biological studies demonstrated that HG increased ROS production, whereas treatment with bFGF or JNK/ERK inhibitors blocked HG-induced ROS accumulation.	ros	154-157	fibroblast growth factor 2	Homo sapiens	108-112
26642060-8	2015	Molecular and cell biological studies demonstrated that HG increased ROS production, whereas treatment with bFGF or JNK/ERK inhibitors blocked HG-induced ROS accumulation.	ros	154-157	mitogen-activated protein kinase 8	Homo sapiens	116-119
26642060-9	2015	Addition of MnTMPyP, a ROS scavenger, reduced HG-induced ROS production and accelerated cell migration, suggesting that the influence of HG on bFGF-MAPK signaling causes accumulation of ROS, which in turn regulate cell migration.	ros	57-60	fibroblast growth factor 2	Homo sapiens	143-147
26642060-8	2015	Molecular and cell biological studies demonstrated that HG increased ROS production, whereas treatment with bFGF or JNK/ERK inhibitors blocked HG-induced ROS accumulation.	ros	154-157	mitogen-activated protein kinase 1	Homo sapiens	120-123
26642060-9	2015	Addition of MnTMPyP, a ROS scavenger, reduced HG-induced ROS production and accelerated cell migration, suggesting that the influence of HG on bFGF-MAPK signaling causes accumulation of ROS, which in turn regulate cell migration.	ros	57-60	fibroblast growth factor 2	Homo sapiens	143-147
26642060-9	2015	Addition of MnTMPyP, a ROS scavenger, reduced HG-induced ROS production and accelerated cell migration, suggesting that the influence of HG on bFGF-MAPK signaling causes accumulation of ROS, which in turn regulate cell migration.	ros	57-60	mitogen-activated protein kinase 1	Homo sapiens	148-152
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	36-39	mitogen-activated protein kinase 14	Homo sapiens	47-50
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	36-39	mitogen-activated protein kinase 14	Homo sapiens	172-175
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	151-154	mitogen-activated protein kinase 14	Homo sapiens	47-50
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	151-154	mitogen-activated protein kinase 14	Homo sapiens	172-175
26013059-7	2015	As a result, a 24-hr exposure of human erythrocytes to naphthazarin (10 muM) significantly decreased erythrocyte forward scatter, significantly increased the percentage of annexin-V-binding cells, significantly increased ceramide abundance at the erythrocyte surface and significantly increased ROS.	ros	295-298	latexin	Homo sapiens	72-75
26514923-0	2015	Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-kB, and AP-1 pathways in human endothelial cells.	ros	58-61	epidermal growth factor receptor	Homo sapiens	72-76
26549478-6	2015	ROS scavenger (N-acetyl cysteine, NAC) could attenuate both the resveratrol induced caspase-3 activity and the formation of acidic vacuoles, but failed to attenuate resveratrol induced PEL cell death.	ros	0-3	caspase 3	Homo sapiens	84-93
26514923-11	2015	These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR-&gt;Erk1/2, JNK1/2-&gt;AP-1 and EGFR-&gt;Akt-&gt;NF-kappaB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells.	ros	64-67	epidermal growth factor receptor	Homo sapiens	78-82
26514923-11	2015	These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR-&gt;Erk1/2, JNK1/2-&gt;AP-1 and EGFR-&gt;Akt-&gt;NF-kappaB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells.	ros	64-67	mitogen-activated protein kinase 3	Homo sapiens	87-93
26514923-11	2015	These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR-&gt;Erk1/2, JNK1/2-&gt;AP-1 and EGFR-&gt;Akt-&gt;NF-kappaB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells.	ros	64-67	epidermal growth factor receptor	Homo sapiens	115-119
26514923-11	2015	These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR-&gt;Erk1/2, JNK1/2-&gt;AP-1 and EGFR-&gt;Akt-&gt;NF-kappaB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells.	ros	64-67	AKT serine/threonine kinase 1	Homo sapiens	124-127
26520405-11	2015	BBP significantly increased ROS production (p&lt;0.05) and ROS may be chiefly regulated by NRF-1 and NRF-2 in HepG2 cells under Sirt1 and Sirt3 silenced condition.	ros	59-62	NFE2 like bZIP transcription factor 2	Homo sapiens	101-106
26498409-8	2015	Overexpression of Nrf2 led to decreased ROS production and cell apoptosis, as well as increased cell viability under PbAc exposure.	ros	40-43	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
26140730-3	2015	Tumor progression is dependent on dominant interference with intercellular apoptosis-inducing ROS signaling through membrane-associated catalase, which decomposes H2O2 and peroxynitrite and oxidizes NO.	ros	94-97	catalase	Homo sapiens	136-144
26140730-8	2015	Tumor cells exhibited tight control of intercellular apoptosis-inducing ROS signaling through a high local concentration of membrane-associated catalase.	ros	72-75	catalase	Homo sapiens	144-152
26475038-7	2015	The results showed that SSa dose-dependently inhibited the production of ROS, TNF-alpha, IL-8, COX-2 and iNOS in LPS-stimulated HUVECs.	ros	73-76	tripartite motif containing 21	Homo sapiens	24-27
26498409-4	2015	As a defense response, Nrf2 was activated when exposed to PbAc, thereby inducing a rapid increase in Nrf2 nuclear accumulation, as well as Nrf2-ARE binding activities in a ROS-dependent manner.	ros	172-175	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
26503118-9	2015	PBK/TOPK KD induced mitochondrial dysfunction and ROS generation, and inhibition of mitochondrial dysfunction and ROS production suppressed PBK/TOPK KD-induced cell cycle arrest and apoptosis.	ros	50-53	PDZ binding kinase	Homo sapiens	0-3
26426154-9	2015	A substantial increase in level of cellular ROS was also evident due to reduced expression of glob1 which consequently leads to locomotor impairment and early aging in surviving adult flies.	ros	44-47	globin 1	Drosophila melanogaster	94-99
26376865-5	2015	Biochemical and functional studies showed a marked increase in ROS-induced lipid peroxidation sustained by altered PPARgamma function, which contributes to the redox imbalance and the compensatory antioxidant activity of ALDH1A1.	ros	63-66	peroxisome proliferator activated receptor gamma	Homo sapiens	115-124
26571396-2	2015	During nonalcoholic fatty liver disease (NAFLD), mitochondria also produce ROS that damage hepatocytes, trigger inflammation, and contribute to insulin resistance.	ros	75-78	insulin	Homo sapiens	144-151
26456051-5	2015	Overexpression of the SHIP2-DN decreased high glucose-induced apoB containing lipoproteins secretion via reduction in ROS generation, JNK phosphorylation and Akt activation.	ros	118-121	apolipoprotein B	Homo sapiens	62-66
26503118-9	2015	PBK/TOPK KD induced mitochondrial dysfunction and ROS generation, and inhibition of mitochondrial dysfunction and ROS production suppressed PBK/TOPK KD-induced cell cycle arrest and apoptosis.	ros	50-53	PDZ binding kinase	Homo sapiens	4-8
26503118-9	2015	PBK/TOPK KD induced mitochondrial dysfunction and ROS generation, and inhibition of mitochondrial dysfunction and ROS production suppressed PBK/TOPK KD-induced cell cycle arrest and apoptosis.	ros	114-117	PDZ binding kinase	Homo sapiens	140-143
26503118-9	2015	PBK/TOPK KD induced mitochondrial dysfunction and ROS generation, and inhibition of mitochondrial dysfunction and ROS production suppressed PBK/TOPK KD-induced cell cycle arrest and apoptosis.	ros	114-117	PDZ binding kinase	Homo sapiens	144-148
26503118-11	2015	Overexpression of Nrf2 inhibited the PBK/TOPK KD-induced decrease in cdc2 and cyclin B expression and cell cycle arrest, and blocked ROS production and apoptosis.	ros	133-136	NFE2 like bZIP transcription factor 2	Homo sapiens	18-22
26503118-11	2015	Overexpression of Nrf2 inhibited the PBK/TOPK KD-induced decrease in cdc2 and cyclin B expression and cell cycle arrest, and blocked ROS production and apoptosis.	ros	133-136	PDZ binding kinase	Homo sapiens	37-40
26503118-11	2015	Overexpression of Nrf2 inhibited the PBK/TOPK KD-induced decrease in cdc2 and cyclin B expression and cell cycle arrest, and blocked ROS production and apoptosis.	ros	133-136	PDZ binding kinase	Homo sapiens	41-45
26503118-13	2015	PBK/TOPK stabilizes Nrf2, strictly regulates the ROS level, promotes cell cycle progression and inhibits apoptosis, contributing to the proliferation of promyelocytes.	ros	49-52	PDZ binding kinase	Homo sapiens	0-3
26503118-13	2015	PBK/TOPK stabilizes Nrf2, strictly regulates the ROS level, promotes cell cycle progression and inhibits apoptosis, contributing to the proliferation of promyelocytes.	ros	49-52	PDZ binding kinase	Homo sapiens	4-8
26225731-9	2015	The biochemical mechanisms described here might be considered as promising principle for the development of novel approaches in tumor therapy that specifically direct membrane-associated catalase of tumor cells and thus utilize tumor cell-specific apoptosis-inducing ROS signaling.	ros	267-270	catalase	Homo sapiens	187-195
26420645-8	2015	Results showed that blocked Nrf2 expression significantly reduced Nrf2 and its target antioxidant enzyme levels, restored ROS levels, and eventually suppressed cell proliferation, migration, and colony formation of the transformed cells.	ros	122-125	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
26342455-4	2015	The regulatory potential of catalase at the crosspoint of ROS and RNS chemical biology, as well as its high local concentration on the outside of the cell membrane of tumor cells, establish tight control of intercellular signaling and thus prevent tumor cell apoptosis.	ros	58-61	catalase	Homo sapiens	28-36
26402162-8	2015	RESULTS: IL6 induced ROS and carbonyl content in all 3 cell lines (all P&lt;0.001).	ros	21-24	interleukin 6	Homo sapiens	9-12
26402162-10	2015	Selenite decreases the IL6-induced ROS and carbonyl content, while enhances Gpx and Trx activities.	ros	35-38	interleukin 6	Homo sapiens	23-26
26420645-8	2015	Results showed that blocked Nrf2 expression significantly reduced Nrf2 and its target antioxidant enzyme levels, restored ROS levels, and eventually suppressed cell proliferation, migration, and colony formation of the transformed cells.	ros	122-125	NFE2 like bZIP transcription factor 2	Homo sapiens	66-70
26420645-9	2015	In summary, the results of the study strongly suggested that the continuous activation of Nrf2 and its target antioxidant enzymes led to the over-depletion of intracellular ROS levels, which contributed to arsenite-induced HBE cell transformation.	ros	173-176	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
26497999-4	2015	We also identified that the EMT and metabolism alterations induced by autophagy inhibition were dependent on ROS-NF-kappaB-HIF-1alpha pathway.	ros	109-112	hypoxia inducible factor 1 subunit alpha	Homo sapiens	123-133
26503908-7	2015	Cell viability and ROS assays indicate that graphene oxide can indeed mitigate cytotoxicity of Abeta peptide amyloids.	ros	19-22	amyloid beta precursor protein	Homo sapiens	95-100
26609358-11	2015	CONCLUSION: Our findings suggest that although G-CSF administration can reduce ARS, it can also exacerbate TBI-induced LT-BM injury in part by promoting HSC senescence via the ROS-p38-p16 pathway.	ros	176-179	cyclin dependent kinase inhibitor 2A	Mus musculus	184-187
26568463-9	2015	that FOXO1 expression was reduced upon stimulation of RANKL; FOXO1 inhibition promoted and FOXO1 activation repressed, osteoclast differentiation and activity; the inhibitory effect of FOXO1 on osteoclastogenesis was partially mediated by ROS since treatment with ROS scavengers cancelled the effect of FOXO1 inhibition on osteoclastogenesis.	ros	239-242	forkhead box O1	Homo sapiens	5-10
26587989-11	2015	Our findings suggest that AGEs increase ROS production, which stimulates downstream pathways related to APP processing, Abeta production, Sirt1, and GRP78, resulting in the up-regulation of cell death related pathway.	ros	40-43	heat shock protein 5	Mus musculus	149-154
26568463-9	2015	that FOXO1 expression was reduced upon stimulation of RANKL; FOXO1 inhibition promoted and FOXO1 activation repressed, osteoclast differentiation and activity; the inhibitory effect of FOXO1 on osteoclastogenesis was partially mediated by ROS since treatment with ROS scavengers cancelled the effect of FOXO1 inhibition on osteoclastogenesis.	ros	264-267	forkhead box O1	Homo sapiens	5-10
26567598-12	2015	Interestingly, we found that PKC proteins were downregulated by EGF in HCE cells that is partially mediated by ROS signaling, while PKC pathway was not involved in EGF-stimulated corneal cell proliferation and migration.	ros	111-114	proline rich transmembrane protein 2	Homo sapiens	29-32
26552848-5	2015	We show that cancer cell death is dependent on ATP release and death signals downstream of P2X7 receptors that can be reversed by inhibition of NADPH oxidases-generated ROS, Ca(2+)/Calmodulin-dependent protein kinase II (CaMKII) or mitochondrial permeability transition pore (MPTP).	ros	169-172	purinergic receptor P2X 7	Homo sapiens	91-95
26212730-3	2015	In our previous study, AGEs increase cell hypertrophy via ERK phosphorylation in a process closely related to ROS production.	ros	110-113	Eph receptor B1	Rattus norvegicus	58-61
26529255-8	2015	In a human macrophage line, depletion of the mitochondrial-enriched sirtuin deacetylase SIRT3 increased NLRP3 inflammasome activation in association with excessive mitochondrial ROS production.	ros	178-181	sirtuin 3	Homo sapiens	88-93
25352423-8	2015	In conclusion, this study demonstrates an association between functional polymorphisms of the IkappaBalpha rs696 and cigarette smoking with the risk of defective spermatogenesis, suggesting some interaction between the NF-kappaB signalling pathway and smoking-related ROS in human spermatogenesis.	ros	268-271	NFKB inhibitor alpha	Homo sapiens	94-106
26560496-10	2015	In eNOS-overexpressing 293 cells, BH4 depletion with 10mM DAHP for 48 hours followed by 50ng/ml VEGF for 30 min to phosphorylate eNOS S1179 increased ROS accumulation compared to DAHP-only treated cells.	ros	150-153	vascular endothelial growth factor A	Homo sapiens	96-100
25199686-8	2015	Endosulfan-induced Akt/MAPK pathways and COX-2 expression were attenuated by DPI, a specific NOX inhibitor, and the ROS scavenger N-acetylcysteine.	ros	116-119	thymoma viral proto-oncogene 1	Mus musculus	19-22
26212730-9	2015	Our results suggest that AGEs inhibit Nrf-2 via the ERK pathway; however, this influence is partly associated with ROS.	ros	115-118	NFE2 like bZIP transcription factor 2	Rattus norvegicus	38-43
26212730-10	2015	Our finding further indicated that AGEs possess both ROS-dependent and ROS-independent pathways, resulting in a reduction in Nrf-2.	ros	53-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-130
26212730-10	2015	Our finding further indicated that AGEs possess both ROS-dependent and ROS-independent pathways, resulting in a reduction in Nrf-2.	ros	71-74	NFE2 like bZIP transcription factor 2	Rattus norvegicus	125-130
26359950-8	2015	KEY RESULTS: S1P stimulated mTOR activation through the Nox2/ROS and PI3K/Akt pathways, which can further stimulate FoxO1 phosphorylation and translocation to the cytosol.	ros	61-64	mechanistic target of rapamycin kinase	Homo sapiens	28-32
26535082-6	2015	PKC inhibitors, MAPK inhibitors, and ROS quenchers also significantly attenuated expression of CXCL8.	ros	37-40	C-X-C motif chemokine ligand 8	Homo sapiens	95-100
26359950-8	2015	KEY RESULTS: S1P stimulated mTOR activation through the Nox2/ROS and PI3K/Akt pathways, which can further stimulate FoxO1 phosphorylation and translocation to the cytosol.	ros	61-64	forkhead box O1	Homo sapiens	116-121
26370081-9	2015	Importantly, human DJ-1, which is implicated in the familial form of Parkinson disease, complements the function of Hsp31 by suppressing methylglyoxal and oxidative stress, thus signifying the importance of these proteins in the maintenance of ROS homeostasis across phylogeny.	ros	244-247	glutathione-independent methylglyoxalase	Saccharomyces cerevisiae S288C	116-121
25154499-9	2015	These results suggest that mammospheres rely on abnormal up-regulation of Nrf2 to maintain low intracellular ROS levels.	ros	109-112	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
26370081-6	2015	Our results show that Hsp31 possesses robust glutathione-independent methylglyoxalase activity and suppresses MG-mediated toxicity and ROS levels as compared with another paralog, Hsp34.	ros	135-138	glutathione-independent methylglyoxalase	Saccharomyces cerevisiae S288C	22-27
26210583-7	2015	Therefore, the inhibition of Cu/ZnSOD activity in these two primary cells may be caused by the oxidative damage of massive ROS or direct interaction with QDs-612.	ros	123-126	superoxide dismutase 1, soluble	Mus musculus	29-37
25726719-9	2015	CONCLUSION: On the basis of these results, the increment of the specific activity of SOD and CAT in pSS patients as compared to control healthy individuals may be seen as a defensive reaction to the increment of the amount of ROS, which becoming uncontrollable, leads to irreversible cellular and tissue damage.	ros	226-229	catalase	Homo sapiens	93-96
26370081-7	2015	On the other hand, glyoxalase-defective mutants of Hsp31 were found highly compromised in regulating the ROS levels.	ros	105-108	glutathione-independent methylglyoxalase	Saccharomyces cerevisiae S288C	51-56
26385178-7	2015	Inhibiting ROS and SHP2 rescued cellular responses to IFN-gamma-induced cytotoxicity and inhibition of cell proliferation in PC14PE6/AS2 cells.	ros	11-14	interferon gamma	Homo sapiens	54-63
26086160-8	2015	Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway.	ros	187-190	mitogen-activated protein kinase 1	Homo sapiens	95-98
26539112-7	2015	The levels of tissue ROS and serum inflammatory cytokines were significantly higher in SOD1(G93A) mice compared to control mice, and knocking down peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) drastically increased cytokine levels in both control and SOD1(G93A) mice.	ros	21-24	superoxide dismutase 1, soluble	Mus musculus	87-91
26450902-5	2015	We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS.	ros	111-114	AKT serine/threonine kinase 1	Homo sapiens	58-61
26086160-8	2015	Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway.	ros	187-190	mitogen-activated protein kinase 8	Homo sapiens	103-106
26164089-4	2015	The results showed that Chemerin increased ROS levels and TG content of C2C12 cells.	ros	43-46	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	24-32
26086160-8	2015	Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway.	ros	187-190	mitogen-activated protein kinase 1	Homo sapiens	107-111
26375553-0	2015	Ovarian clear cell carcinoma meets metabolism; HNF-1beta confers survival benefits through the Warburg effect and ROS reduction.	ros	114-117	HNF1 homeobox B	Homo sapiens	47-56
26220687-5	2015	We also show that the increased COX-2 expression associates with intracellular ROS generation, up-regulated AKT signaling, with activation of both NFAT and NF-kappaB pathways.	ros	79-82	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
26220687-6	2015	We demonstrate that antioxidant enzymes have an inhibitory effect on arsenic/ethanol-induced COX-2 expression, indicating that the responsive signaling pathways from co-exposure to arsenic and ethanol relate to ROS generation.	ros	211-214	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	93-98
26334958-7	2015	In this process, TRIP-Br1 confers resistance to serum starvation-induced cell deaths by stabilizing the XIAP protein and inhibiting cellular ROS production.	ros	141-144	SERTA domain containing 1	Homo sapiens	17-25
26264915-1	2015	We previously demonstrated that elevated levels of ROS in red blood cells (RBCs) are responsible for anemia in SOD1-deficient mice, suggesting that the oxidative stress-induced massive destruction of RBCs is an underlying mechanism for autoimmune hemolytic anemia.	ros	51-54	superoxide dismutase 1, soluble	Mus musculus	111-115
26437801-7	2015	Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFalpha in an ATP7A-independent manner.	ros	121-124	antioxidant 1 copper chaperone	Mus musculus	10-15
26437801-7	2015	Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFalpha in an ATP7A-independent manner.	ros	121-124	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-133
26437801-7	2015	Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFalpha in an ATP7A-independent manner.	ros	121-124	tumor necrosis factor	Mus musculus	202-210
26437801-7	2015	Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFalpha in an ATP7A-independent manner.	ros	121-124	ATPase, Cu++ transporting, alpha polypeptide	Mus musculus	217-222
26408692-5	2015	GADD34 decreased phosphorylated eIF2alpha and increased ROS production and the levels of ubiquinated protein.	ros	56-59	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	0-6
26408692-7	2015	CONCLUSION: GADD34 plays a vital role in promoting cell death following proteasome inhibition via enhancing protein synthesis to activate death-associated mechanisms, including ER stress, ROS production and autophagy formation.	ros	188-191	protein phosphatase 1 regulatory subunit 15A	Homo sapiens	12-18
26101063-5	2015	Fisetin significantly attenuated TPA-induced cell invasion in MCF-7 human breast cancer cells, and was found to inhibit the activation of the PKCalpha/ROS/ERK1/2 and p38 MAPK signaling pathways.	ros	151-154	protein kinase C alpha	Homo sapiens	142-150
26189441-0	2015	SREBP-1c overactivates ROS-mediated hepatic NF-kappaB inflammatory pathway in dairy cows with fatty liver.	ros	23-26	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
26189441-8	2015	SREBP-1c overexpression overactivated the NF-kappaB inflammatory pathway in hepatocytes by increasing ROS content and not through TLR4.	ros	102-105	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-51
26189441-11	2015	Taken together, these results indicate that SREBP-1c enhances the NEFA-induced overactivation of the NF-kappaB inflammatory pathway by increasing ROS in cow hepatocytes, thereby further increasing hepatic inflammatory injury in cows with fatty liver.	ros	146-149	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
26327128-4	2015	Using siRNA and Epigallocatechin gallate (EGCG), we found that GRP78 and Survivin cooperatively conferred MDR by decreasing FD-induced ROS generation.	ros	135-138	heat shock protein family A (Hsp70) member 5	Homo sapiens	63-68
26143630-7	2015	Cardiac NLRP3 inflammasome was activated with elevated myocardial IL-1beta and IL-18 concentrations mediated by ROS over-production and TXNIP over-expression in MI dogs.	ros	112-115	interleukin 1 beta	Canis lupus familiaris	66-74
26143630-10	2015	CONCLUSIONS: These data firstly demonstrated that cardiac NLRP3 inflammasome activation driven by cardiac ROS over-production and TXNIP up-expression resulted in impairment of the JAK2-STAT3 and insulin signaling pathways, leading to disorder of lipid metabolism in myocardial ischemic dogs through PPAR-alpha over-expression.	ros	106-109	signal transducer and activator of transcription 3	Canis lupus familiaris	185-190
25820554-0	2015	ROS-Induced Nuclear Translocation of Calpain-2 Facilitates Cardiomyocyte Apoptosis in Tail-Suspended Rats.	ros	0-3	calpain 2	Rattus norvegicus	37-46
25820554-3	2015	In the present study, the results showed that ISO (10 nM) significantly elevated NADPH oxidases (NOXs) activity and NOXs-derived ROS productions which induced nuclear translocation of calpain-2 in cardiomyocytes of tail-suspended rats.	ros	129-132	calpain 2	Rattus norvegicus	184-193
25820554-4	2015	In contrast, the inhibition of NADPH oxidase or cleavage of ROS not only reduced ROS productions, but also resisted nuclear translocation of calpain-2 and decreased ISO-induced apoptosis of cardiomyocyte in tail-suspended rats.	ros	60-63	calpain 2	Rattus norvegicus	141-150
25820554-8	2015	In summary, the above results suggest that ISO increased NOXs-derived ROS which activated nuclear translocation of calpain-2, subsequently nuclear calpain-2 degraded CaMK II deltaB which reduced the ratio of Bcl-2 to Bax, and finally the mitochondria apoptosis pathway was triggered in tail-suspended rat cardiomyocytes.	ros	70-73	calpain 2	Rattus norvegicus	115-124
26489615-6	2015	Pretreatment with 11, 12-EET also significantly blocked TNF-alpha-induced ROS production.	ros	74-77	tumor necrosis factor	Homo sapiens	56-65
25911596-8	2015	An enhanced subcellular level of ROS by spheroidal cluster yielded the high concentrations of L-Kynurenine (1.67 +- 0.6 muM without H2O2, 5.2 +- 1.14 muM with 50 muM of H2O2 and 8.8 +- 0.51 muM with 100 muM of H2O2), supporting the IDO-mediated tryptophan replacement process.	ros	33-36	latexin	Homo sapiens	120-123
25911596-8	2015	An enhanced subcellular level of ROS by spheroidal cluster yielded the high concentrations of L-Kynurenine (1.67 +- 0.6 muM without H2O2, 5.2 +- 1.14 muM with 50 muM of H2O2 and 8.8 +- 0.51 muM with 100 muM of H2O2), supporting the IDO-mediated tryptophan replacement process.	ros	33-36	latexin	Homo sapiens	150-153
25911596-8	2015	An enhanced subcellular level of ROS by spheroidal cluster yielded the high concentrations of L-Kynurenine (1.67 +- 0.6 muM without H2O2, 5.2 +- 1.14 muM with 50 muM of H2O2 and 8.8 +- 0.51 muM with 100 muM of H2O2), supporting the IDO-mediated tryptophan replacement process.	ros	33-36	latexin	Homo sapiens	150-153
25911596-8	2015	An enhanced subcellular level of ROS by spheroidal cluster yielded the high concentrations of L-Kynurenine (1.67 +- 0.6 muM without H2O2, 5.2 +- 1.14 muM with 50 muM of H2O2 and 8.8 +- 0.51 muM with 100 muM of H2O2), supporting the IDO-mediated tryptophan replacement process.	ros	33-36	latexin	Homo sapiens	150-153
25911596-8	2015	An enhanced subcellular level of ROS by spheroidal cluster yielded the high concentrations of L-Kynurenine (1.67 +- 0.6 muM without H2O2, 5.2 +- 1.14 muM with 50 muM of H2O2 and 8.8 +- 0.51 muM with 100 muM of H2O2), supporting the IDO-mediated tryptophan replacement process.	ros	33-36	latexin	Homo sapiens	150-153
26119525-5	2015	COX-2 protein up-regulation probably is mediated by ROS, produced during fluoride-induced inflammatory reactions.	ros	52-55	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
26165189-6	2015	A ROS inducer, antimycin A, caused an increase in both the number and size of the mitochondrial M-LPH foci, and these foci were co-localized with two enzymes, DNA polymerase gamma (POLG) and DNA ligase III (LIG3), both involved in mtDNA repair.	ros	2-5	melanophilin	Homo sapiens	96-101
26010461-11	2015	Capsaicin-induced microglial migration was inhibited by membrane-permeable antioxidants and MAPK inhibitors, suggesting that mitochondrial TRPV1 activation induced Ca(2+) -dependent production of ROS followed by MAPK activation, which correlated with an augmented migration of microglia.	ros	196-199	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	139-144
25863936-7	2015	The association of the pore opening with Ca(2+) efflux and ROS increase was proved by the inhibition of Bcl-2 overexpression and cyclosporine A treatment.	ros	59-62	BCL2 apoptosis regulator	Homo sapiens	104-109
26387735-6	2015	Silencing or disruption of SPG7-CypD binding prevented Ca(2+)- and ROS-induced DeltaPsim depolarization and cell death.	ros	67-70	peptidylprolyl isomerase F	Homo sapiens	32-36
26327128-5	2015	Our data showed that FD increases GRP78 and Survivin, which serve as ROS inhibitors, causing MDR in HCC.	ros	69-72	heat shock protein family A (Hsp70) member 5	Homo sapiens	34-39
26235743-0	2015	New benzimidazole acridine derivative induces human colon cancer cell apoptosis in vitro via the ROS-JNK signaling pathway.	ros	97-100	mitogen-activated protein kinase 8	Homo sapiens	101-104
26277391-2	2015	Our data showed that DFO significantly decreased LPS-induced LIP and ROS upregulation.	ros	69-72	toll-like receptor 4	Mus musculus	49-52
26201953-0	2015	MicroRNAs and PARP: co-conspirators with ROS in pulmonary hypertension.	ros	41-44	poly(ADP-ribose) polymerase 1	Homo sapiens	14-18
26368019-12	2015	Inhibition of ROS and p53 respectively reversed the cell death induced by 5-Fu + Gyp, suggesting the key roles of ROS and p53 in the process.	ros	14-17	tumor protein p53	Homo sapiens	122-125
26368019-12	2015	Inhibition of ROS and p53 respectively reversed the cell death induced by 5-Fu + Gyp, suggesting the key roles of ROS and p53 in the process.	ros	114-117	tumor protein p53	Homo sapiens	22-25
25736529-5	2015	In primary striatal neurons, we observed that treatment with the mGluR5 agonist CHPG increased the phosphorylation level of extracellular signal-regulated kinase (ERK), which was dependent on the mGluR5-inositol-1,4,5-trisphosphate-reactive oxygen species (ROS) pathway.	ros	257-260	Eph receptor B1	Rattus norvegicus	124-161
25736529-5	2015	In primary striatal neurons, we observed that treatment with the mGluR5 agonist CHPG increased the phosphorylation level of extracellular signal-regulated kinase (ERK), which was dependent on the mGluR5-inositol-1,4,5-trisphosphate-reactive oxygen species (ROS) pathway.	ros	257-260	Eph receptor B1	Rattus norvegicus	163-166
26235743-11	2015	CONCLUSION: The new benzimidazole acridine derivative, 8m exerts anticancer activity against human colon cancer cells in vitro by inducing both intrinsic and extrinsic apoptosis pathways via the ROS-JNK1 pathway.	ros	195-198	mitogen-activated protein kinase 8	Homo sapiens	199-203
26210873-7	2015	PPAR-gamma agonists protected OL progenitors against the inhibitory activities of both TNF-alpha and rotenone on mMP, mitochondrial ROS production, Ca(2+) oscillations and OL differentiation.	ros	132-135	peroxisome proliferator activated receptor gamma	Homo sapiens	0-10
26254337-10	2015	In summary, we, for the first time, demonstrate that chemerin/chemokine-like receptor 1 stimulates SMC proliferation and migration via ROS-dependent phosphorylation of Akt/ERK, which may lead to vascular structural remodeling and an increase in systolic blood pressure.	ros	135-138	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	53-61
26254337-10	2015	In summary, we, for the first time, demonstrate that chemerin/chemokine-like receptor 1 stimulates SMC proliferation and migration via ROS-dependent phosphorylation of Akt/ERK, which may lead to vascular structural remodeling and an increase in systolic blood pressure.	ros	135-138	thymoma viral proto-oncogene 1	Mus musculus	168-171
26254337-10	2015	In summary, we, for the first time, demonstrate that chemerin/chemokine-like receptor 1 stimulates SMC proliferation and migration via ROS-dependent phosphorylation of Akt/ERK, which may lead to vascular structural remodeling and an increase in systolic blood pressure.	ros	135-138	mitogen-activated protein kinase 1	Mus musculus	172-175
26212545-0	2015	Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.	ros	67-70	signal transducer and activator of transcription 3	Homo sapiens	16-21
26212545-0	2015	Sugiol inhibits STAT3 activity via regulation of transketolase and ROS-mediated ERK activation in DU145 prostate carcinoma cells.	ros	67-70	mitogen-activated protein kinase 1	Homo sapiens	80-83
26212545-6	2015	Notably, we observed that sugiol interacted with transketolase, an enzyme in central metabolism, and increased ROS levels leading to the activation of ERK, which inhibits STAT3 activity.	ros	111-114	mitogen-activated protein kinase 1	Homo sapiens	151-154
26212545-9	2015	We propose that sugiol inhibits STAT3 activity through a mechanism that involves the inhibition of transketolase, which leads to increased ROS levels and MEG2 activation in DU145 cells.	ros	139-142	signal transducer and activator of transcription 3	Homo sapiens	32-37
26212545-9	2015	We propose that sugiol inhibits STAT3 activity through a mechanism that involves the inhibition of transketolase, which leads to increased ROS levels and MEG2 activation in DU145 cells.	ros	139-142	transketolase	Homo sapiens	99-112
26111808-8	2015	Co-treatment of vitamin E (Vit E) with OTA, CTN and OTA + CTN reduced the levels of ROS and the cytotoxicity.	ros	84-87	vitrin	Homo sapiens	27-30
26254337-6	2015	Chemerin significantly increased ROS production in SMCs and phosphorylation of Akt (Ser(473)) and ERK, as measured by fluorescent staining and Western blot analysis, respectively.	ros	33-36	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	0-8
26117230-5	2015	Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression and protecting against 1-methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity in SH-SY5Y cells.	ros	159-162	paraoxonase 1	Homo sapiens	58-62
25541056-5	2015	Butein decreased TNF-alpha-induced ROS generation in a dose-dependent manner in HaCaT cells.	ros	35-38	tumor necrosis factor	Homo sapiens	17-26
26232272-3	2015	BNip3 delays primary mammary tumor growth and progression by preventing the accumulation of dysfunctional mitochondria and resultant excess ROS production.	ros	140-143	BCL2 interacting protein 3	Homo sapiens	0-5
26232272-4	2015	In the absence of BNip3, mammary tumor cells are unable to reduce mitochondrial mass effectively and elevated mitochondrial ROS increases the expression of Hif-1alpha and Hif target genes, including those involved in glycolysis and angiogenesis:two processes that are also markedly increased in BNip3-null tumors.	ros	124-127	hypoxia inducible factor 1 subunit alpha	Homo sapiens	156-166
26232272-4	2015	In the absence of BNip3, mammary tumor cells are unable to reduce mitochondrial mass effectively and elevated mitochondrial ROS increases the expression of Hif-1alpha and Hif target genes, including those involved in glycolysis and angiogenesis:two processes that are also markedly increased in BNip3-null tumors.	ros	124-127	BCL2 interacting protein 3	Homo sapiens	295-300
26210873-8	2015	Finally, the PPAR-gamma agonist pioglitazone increased the expression of PGC-1alpha (a mitochondrial biogenesis master regulator), UCP2 (a mitochondrial protein known to reduce ROS production), and cytochrome oxidase subunit COX1.	ros	177-180	peroxisome proliferator activated receptor gamma	Homo sapiens	13-23
26210873-7	2015	PPAR-gamma agonists protected OL progenitors against the inhibitory activities of both TNF-alpha and rotenone on mMP, mitochondrial ROS production, Ca(2+) oscillations and OL differentiation.	ros	132-135	tumor necrosis factor	Homo sapiens	87-96
26196303-1	2015	BACKGROUND AND PURPOSE: This study aims to investigate whether and how pharmacological activation of AMP-activated protein kinase (AMPK) improves endothelial function by suppressing mitochondrial ROS-associated endoplasmic reticulum stress (ER stress) in the endothelium.	ros	196-199	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	101-129
26021820-10	2015	We further demonstrated that Nrf2 translocation was mediated by PI3K/AKT, PKC, or ROS signaling cascades.	ros	82-85	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
26021820-12	2015	Besides, increased basal ROS by EGT appears to be crucial for triggering the Nrf2/ARE signaling pathways.	ros	25-28	NFE2 like bZIP transcription factor 2	Homo sapiens	77-81
26001727-0	2015	c-Jun N-terminal kinase attenuates TNFalpha signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells.	ros	91-94	mitogen-activated protein kinase 8	Homo sapiens	0-23
26001727-0	2015	c-Jun N-terminal kinase attenuates TNFalpha signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells.	ros	91-94	tumor necrosis factor	Homo sapiens	35-43
26001727-11	2015	These data suggest that JNK suppresses the inflammatory response to TNFalpha by reducing Nox1-dependent endosomal ROS production.	ros	114-117	mitogen-activated protein kinase 8	Homo sapiens	24-27
26001727-11	2015	These data suggest that JNK suppresses the inflammatory response to TNFalpha by reducing Nox1-dependent endosomal ROS production.	ros	114-117	tumor necrosis factor	Homo sapiens	68-76
26196303-5	2015	AMPK activators salicylate and AICAR prevented ROS-induced mitochondrial fission by enhancing dynamin-related protein 1 (Drp1) phosphorylation (Ser 637) and thereby attenuated IRE-1alpha and PERK phosphorylation, but their actions were blocked by knockdown of AMPK.	ros	47-50	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	0-4
26196303-1	2015	BACKGROUND AND PURPOSE: This study aims to investigate whether and how pharmacological activation of AMP-activated protein kinase (AMPK) improves endothelial function by suppressing mitochondrial ROS-associated endoplasmic reticulum stress (ER stress) in the endothelium.	ros	196-199	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	131-135
26196303-5	2015	AMPK activators salicylate and AICAR prevented ROS-induced mitochondrial fission by enhancing dynamin-related protein 1 (Drp1) phosphorylation (Ser 637) and thereby attenuated IRE-1alpha and PERK phosphorylation, but their actions were blocked by knockdown of AMPK.	ros	47-50	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	260-264
26196303-10	2015	CONCLUSION AND IMPLICATIONS: Pharmacological activation of AMPK regulated mitochondrial morphology and ameliorated endothelial dysfunction by suppression of mitochondrial ROS-associated ER stress and subsequent TXNIP/NLRP3 inflammasome activation.	ros	171-174	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	59-63
26205253-5	2015	Internalized nanoparticles trigger glioma cell apoptosis by activation of ROS-mediated p53 phosphorylation.	ros	74-77	tumor protein p53	Homo sapiens	87-90
26305254-0	2015	Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE-/- Mice through the ROS/MAPK/NF-kappaB Pathway.	ros	93-96	apolipoprotein E	Mus musculus	68-72
26133502-0	2015	Nrf2 facilitates repair of radiation induced DNA damage through homologous recombination repair pathway in a ROS independent manner in cancer cells.	ros	109-112	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
27551455-3	2015	In this study, our results showed that human THP-1-derived macrophages infected with M. abscessus presented an increase in ROS production and cell necrosis.	ros	123-126	GLI family zinc finger 2	Homo sapiens	45-50
26305254-0	2015	Apple Polyphenols Decrease Atherosclerosis and Hepatic Steatosis in ApoE-/- Mice through the ROS/MAPK/NF-kappaB Pathway.	ros	93-96	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-111
26305254-9	2015	Mechanistically, the APs treatment suppressed the ROS/MAPK/NF-kappaB signaling pathway, and consequently, reduced CCL-2, ICAM-1 and VCAM-1 expression.	ros	50-53	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	59-68
24382131-6	2015	RECENT ADVANCES: More recently, the analysis of oxidative stress focused on enzymatic pathways generating ROS, such as NADPH oxidase and myeloperoxidase (MPO).	ros	106-109	myeloperoxidase	Homo sapiens	137-152
26203587-14	2015	In addition, the quenching of ROS using NAC prevented the induction of JNK phosphorylation and CHOP induction.	ros	30-33	mitogen-activated protein kinase 8	Homo sapiens	71-74
26203587-14	2015	In addition, the quenching of ROS using NAC prevented the induction of JNK phosphorylation and CHOP induction.	ros	30-33	DNA damage inducible transcript 3	Homo sapiens	95-99
26203587-15	2015	Furthermore, inhibition of ROS by NAC significantly attenuated TRAIL sensitization by TIIA.	ros	27-30	TNF superfamily member 10	Homo sapiens	63-68
26203587-16	2015	Taken together, these data suggest that TIIA enhances TRAIL-induced apoptosis by upregulating DR5 receptors through the ROS-JNK-CHOP signaling axis in human ovarian carcinoma cells.	ros	120-123	TNF superfamily member 10	Homo sapiens	54-59
26203587-16	2015	Taken together, these data suggest that TIIA enhances TRAIL-induced apoptosis by upregulating DR5 receptors through the ROS-JNK-CHOP signaling axis in human ovarian carcinoma cells.	ros	120-123	mitogen-activated protein kinase 8	Homo sapiens	124-127
24382131-6	2015	RECENT ADVANCES: More recently, the analysis of oxidative stress focused on enzymatic pathways generating ROS, such as NADPH oxidase and myeloperoxidase (MPO).	ros	106-109	myeloperoxidase	Homo sapiens	154-157
25862413-1	2015	Oxygen-derived free radicals (ROS) have been identified to contribute significantly to ischemia-reperfusion (I/R) injury by initiating chain reactions with polyunsaturated membrane lipids (lipid peroxidation, LPO) resulting in the generation of several aldehydes and ketones.	ros	30-33	lactoperoxidase	Homo sapiens	209-212
26079889-3	2015	Noteworthy, we have previously demonstrated that EGFR/Rac1/reactive oxygen species (ROS)/matrix metalloproteinase 9 (MMP-9) is a key signaling cascade regulating MUC5AC production in airway cells challenged with LPS.	ros	84-87	epidermal growth factor receptor	Homo sapiens	49-53
26079889-7	2015	This signaling pathway not only includes Rac1, ROS and MMP-9, but also NF-kappaB, since we have found that ROS require NF-kappaB activity to induce MMP-9 secretion and activation.	ros	47-50	nuclear factor kappa B subunit 1	Homo sapiens	119-128
26079889-7	2015	This signaling pathway not only includes Rac1, ROS and MMP-9, but also NF-kappaB, since we have found that ROS require NF-kappaB activity to induce MMP-9 secretion and activation.	ros	107-110	nuclear factor kappa B subunit 1	Homo sapiens	71-80
26079889-7	2015	This signaling pathway not only includes Rac1, ROS and MMP-9, but also NF-kappaB, since we have found that ROS require NF-kappaB activity to induce MMP-9 secretion and activation.	ros	107-110	nuclear factor kappa B subunit 1	Homo sapiens	119-128
26349987-3	2015	Our results provide novel insight that UCP2 may protect hippocampal neurons exposed to amyloid beta protein through decreasing ROS production.	ros	127-130	amyloid beta precursor protein	Homo sapiens	87-99
25449851-3	2015	We explore these reports and the possibility that activation of the mTOR/p70S6K kinase pathway may represent a ROS-mediated response to mitochondrial stress leading to the activation of senescence.	ros	111-114	mechanistic target of rapamycin kinase	Homo sapiens	68-72
26102024-0	2015	Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress.	ros	72-75	interleukin 1 beta	Homo sapiens	32-40
26102024-0	2015	Inhibition of autophagy induces IL-1beta release from ARPE-19 cells via ROS mediated NLRP3 inflammasome activation under high glucose stress.	ros	72-75	NLR family pyrin domain containing 3	Homo sapiens	85-90
26248074-3	2015	UCP2, a mitochondrial membrane protein, which influences cardiac ROS formation was reported to interact with the MCU.	ros	65-68	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	0-4
25850711-8	2015	We describe a novel Rac1-, ROS- and MAVS-mediated signalling cascade through which dynasore dramatically activates NF-kappaB, mimicking the viral induction of this key inflammatory signalling pathway.	ros	27-30	nuclear factor kappa B subunit 1	Homo sapiens	115-124
25650185-0	2015	FV-429 Induced Apoptosis Through ROS-Mediated ERK2 Nuclear Translocation and p53 Activation in Gastric Cancer Cells.	ros	33-36	mitogen-activated protein kinase 1	Homo sapiens	46-50
25650185-4	2015	Further research revealed that the mitogen-activated protein kinases, including c-Jun N-terminal kinase, extracellular regulated kinase, and p38 mitogen-activated protein kinase, could be activated by FV-429-induced high level ROS.	ros	227-230	mitogen-activated protein kinase 14	Homo sapiens	141-177
26033363-12	2015	Downstream activation of NFkappaB and rate of generation of ROS was also decreased on gene silencing of TLR4 and exposure to anti-HMGB1.	ros	60-63	toll-like receptor 4	Rattus norvegicus	104-108
26059056-0	2015	Curcumin inhibits the invasion of lung cancer cells by modulating the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway.	ros	85-88	protein kinase C alpha	Homo sapiens	70-78
26202022-4	2015	As a sensor of cellular stress, p53 is a relevant messenger of cell death signaling in ROS-driven photodynamic therapy (PDT) of cancer.	ros	87-90	tumor protein p53	Homo sapiens	32-35
26107995-7	2015	Interestingly, RuPOP@MWCNTs significantly enhanced the anticancer efficacy of clinically used X-ray against R-HepG2 cells through induction of apoptosis and G0/G1 cell cycle arrest, with the involvement of ROS overproduction, which activated several downstream signaling pathways, including DNA damage-mediated p53 phosphorylation, activation of p38, and inactivation of AKT and ERK.	ros	206-209	tumor protein p53	Homo sapiens	311-314
26107995-7	2015	Interestingly, RuPOP@MWCNTs significantly enhanced the anticancer efficacy of clinically used X-ray against R-HepG2 cells through induction of apoptosis and G0/G1 cell cycle arrest, with the involvement of ROS overproduction, which activated several downstream signaling pathways, including DNA damage-mediated p53 phosphorylation, activation of p38, and inactivation of AKT and ERK.	ros	206-209	mitogen-activated protein kinase 14	Homo sapiens	346-349
26107995-7	2015	Interestingly, RuPOP@MWCNTs significantly enhanced the anticancer efficacy of clinically used X-ray against R-HepG2 cells through induction of apoptosis and G0/G1 cell cycle arrest, with the involvement of ROS overproduction, which activated several downstream signaling pathways, including DNA damage-mediated p53 phosphorylation, activation of p38, and inactivation of AKT and ERK.	ros	206-209	AKT serine/threonine kinase 1	Homo sapiens	371-374
26107995-7	2015	Interestingly, RuPOP@MWCNTs significantly enhanced the anticancer efficacy of clinically used X-ray against R-HepG2 cells through induction of apoptosis and G0/G1 cell cycle arrest, with the involvement of ROS overproduction, which activated several downstream signaling pathways, including DNA damage-mediated p53 phosphorylation, activation of p38, and inactivation of AKT and ERK.	ros	206-209	mitogen-activated protein kinase 1	Homo sapiens	379-382
25193021-7	2015	While iPLA2 activity was increased in PRDX6 Tg mice followed by an increase in the level of ROS and 4-hydroxynonenal (4-HNE).	ros	92-95	phospholipase A2, group VI	Mus musculus	6-11
26059056-13	2015	In conclusion, the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway is activated in lung cancer A549 cells, which could be modulated by curcumin to inhibit cell invasiveness.	ros	34-37	protein kinase C alpha	Homo sapiens	19-27
26002468-0	2015	Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK.	ros	51-54	mitogen-activated protein kinase 8	Homo sapiens	65-68
26002468-0	2015	Palmitate promotes autophagy and apoptosis through ROS-dependent JNK and p38 MAPK.	ros	51-54	mitogen-activated protein kinase 14	Homo sapiens	73-81
26002468-8	2015	Thus, we demonstrate that PA stimulates autophagy and apoptosis via ROS-dependent JNK and p38 MAPK pathways.	ros	68-71	mitogen-activated protein kinase 8	Homo sapiens	82-85
26002468-8	2015	Thus, we demonstrate that PA stimulates autophagy and apoptosis via ROS-dependent JNK and p38 MAPK pathways.	ros	68-71	mitogen-activated protein kinase 14	Homo sapiens	90-93
26009488-2	2015	Here we provide findings that Clnk may be is required for TNF induced cell death, it functions downstream of RIP3 and promotes TNF- induced ROS generation and MLKL tetramer formation and subsequent necrosis of L929 cells.	ros	140-143	tumor necrosis factor	Mus musculus	127-130
26002466-5	2015	In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1alpha-induced expression of C/EBPbeta and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2).	ros	203-206	interleukin 1 alpha	Rattus norvegicus	129-138
26017975-9	2015	TNF effects on TRPC6 trafficking required ROS.	ros	42-45	tumor necrosis factor	Homo sapiens	0-3
25684443-10	2015	Administration of diphenyliodonium to allergic mice also led to improvement of allergic airway responses via inhibition of the DUOX-2/ROS pathway; however, these effects were less pronounced than PAR-2 antagonism.	ros	134-137	dual oxidase 2	Mus musculus	127-133
26148005-2	2015	Previous studies using in vitro endothelial tubes as a simplified model of capillaries have found that DEP-induced ROS increase vascular permeability with rearrangement or internalization of adherens junctional VE-cadherin away from the plasma membrane.	ros	115-118	cadherin 5	Homo sapiens	211-222
26148005-10	2015	Our data suggests that DEP-induced intracellular ROS and release of the pro-inflammatory cytokines TNF- alpha and IL-6, which would contribute to VEGF-A secretion and disrupt cell-cell borders and increase vasculature permeability.	ros	49-52	vascular endothelial growth factor A	Homo sapiens	146-152
25931145-4	2015	We demonstrate that strong stimuli (e.g. intact Escherichia coli or LPS in addition to IL-1beta) induce IL-12p70 via a ROS/RELA/CDK9 pathway that is inhibited by simultaneous JAK1/STAT3 signalling.	ros	119-122	Janus kinase 1	Homo sapiens	175-179
25857619-13	2015	Exposure to lipopolysaccharide induced a dramatic increase in both NF-kappaB activation and IL-6 expression in both wt and mdx myotubes, suggesting that the altered IL-6 gene expression after electrical stimulation in mdx muscle cells is due to dysregulation of Ca2+ release and ROS production, both of which impinge on NF-kappaB signaling.	ros	279-282	interleukin 6	Homo sapiens	165-169
26010513-9	2015	Furthermore, linagliptin alleviated Abeta-induced mitochondrial dysfunction and intracellular ROS generation, which may be due to the activation of 5" AMP-activated protein kinase (AMPK)-Sirt1 signaling.	ros	94-97	amyloid beta precursor protein	Homo sapiens	36-41
25684443-11	2015	The current study suggests that PAR-2 activation leads to up-regulation of the DUOX-2/ROS pathway in AECs, which is involved in regulation of airway reactivity and inflammation via oxidative stress and apoptosis.	ros	86-89	dual oxidase 2	Mus musculus	79-85
26053663-8	2015	Using intestinal organoid cultures, we found that, compared with those from WT animals, Sepp1-null cultures display increased stem cell characteristics that are coupled with increased ROS production, DNA damage, proliferation, decreased cell survival, and modulation of WNT signaling in response to H2O2-mediated oxidative stress.	ros	184-187	selenoprotein P	Homo sapiens	88-93
26339354-8	2015	These results indicate that glutamine has protective effects on I/R in vivo by activating the Nrf2/ARE signaling pathway to inhibit ROS production and reduce intestinal apoptosis.	ros	132-135	NFE2 like bZIP transcription factor 2	Rattus norvegicus	94-98
26073944-5	2015	We linked ROS production and induction of the mitochondrial permeability transition pore (MPTP) via cyclophilin D and p53 as mechanisms of EPHOSS.	ros	10-13	tumor protein p53	Homo sapiens	118-121
25963661-2	2015	Its expression in skeletal muscle (SKM) is induced by hypoxia and reactive oxidative species (ROS) generated during exercise, suggesting that PGC-1alpha might mediate the cross talk between oxidative metabolism and cellular responses to hypoxia and ROS.	ros	94-97	PPARG coactivator 1 alpha	Homo sapiens	142-152
25963661-2	2015	Its expression in skeletal muscle (SKM) is induced by hypoxia and reactive oxidative species (ROS) generated during exercise, suggesting that PGC-1alpha might mediate the cross talk between oxidative metabolism and cellular responses to hypoxia and ROS.	ros	249-252	PPARG coactivator 1 alpha	Homo sapiens	142-152
25963661-3	2015	Here we found that PGC-1alpha directly interacted with Bhlhe40, a basic helix-loop-helix (bHLH) transcriptional repressor induced by hypoxia, and protects SKM from ROS damage, and they cooccupied PGC-1alpha-targeted gene promoters/enhancers, which in turn repressed PGC-1alpha transactivational activity.	ros	164-167	PPARG coactivator 1 alpha	Homo sapiens	19-29
26053025-2	2015	ABCB10 has been shown to protect the heart from the impact of ROS during ischemia-reperfusion and to allow for proper hemoglobin synthesis during erythroid development.	ros	62-65	ATP binding cassette subfamily B member 10	Homo sapiens	0-6
26106584-4	2015	Thus, downstream of different signals, both nuclear, Y-P STAT3, and mitochondrial, S-P STAT3, can act by promoting cell survival and reducing ROS production.	ros	142-145	signal transducer and activator of transcription 3	Homo sapiens	57-62
26106584-4	2015	Thus, downstream of different signals, both nuclear, Y-P STAT3, and mitochondrial, S-P STAT3, can act by promoting cell survival and reducing ROS production.	ros	142-145	signal transducer and activator of transcription 3	Homo sapiens	87-92
26063499-11	2015	Furthermore, LA induced ROS generation which could be involved in the CHOP induction which is known to activate the Bim translation.	ros	24-27	DNA damage inducible transcript 3	Homo sapiens	70-74
25877926-5	2015	Agonists that activate TLR7 and TLR8 induce priming of neutrophil ROS production; however, which receptor is involved in this process has not been elucidated.	ros	66-69	toll like receptor 7	Homo sapiens	23-27
28962422-8	2015	Results indicated the significantly increasing expression of ROS and 8-OHdG which accompanied with STAT3 hypomethylation in 1,4-BQ-treated AHH-1 cells.	ros	61-64	signal transducer and activator of transcription 3	Homo sapiens	99-104
25615876-3	2015	The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs.	ros	208-211	mitogen-activated protein kinase 8	Homo sapiens	142-145
25877926-5	2015	Agonists that activate TLR7 and TLR8 induce priming of neutrophil ROS production; however, which receptor is involved in this process has not been elucidated.	ros	66-69	toll like receptor 8	Homo sapiens	32-36
25877926-10	2015	These results indicate that TLR8, but not TLR7, is involved in priming of human neutrophil ROS production by inducing the phosphorylation of p47phox and p38MAPK and that Pin1 is also involved in this process.	ros	91-94	toll like receptor 8	Homo sapiens	28-32
25609738-6	2015	The effect of the TNFalpha blocker, adalimumab (Ada), was evaluated on TNFalpha-induced ROS production.	ros	88-91	tumor necrosis factor	Homo sapiens	18-26
25609738-15	2015	Adding a TNFalpha blocker, Ada, blocked this ROS production, but not the oxidative stress in blood samples from haemodialysis patients, suggesting that other uraemic toxins than TNFalpha are more crucial in this process.	ros	45-48	tumor necrosis factor	Homo sapiens	9-17
25824337-8	2015	Moreover, the IL6-induced changes in C57 mice, including augmented MDSC recruitment, increased levels of ROS and p-Stat3 in MDSCs, and higher suppressive function of MDSCs in T-cell proliferation, which were abrogated by calcitriol supplementation.	ros	105-108	interleukin 6	Mus musculus	14-17
25609738-6	2015	The effect of the TNFalpha blocker, adalimumab (Ada), was evaluated on TNFalpha-induced ROS production.	ros	88-91	tumor necrosis factor	Homo sapiens	71-79
25609738-8	2015	RESULTS: While interleukin (IL)-6, IL-1beta and IL-18 alone induced no ROS activation of normal leukocytes, irrespective of concentrations, TNFalpha induced ROS activation at baseline (P &lt; 0.01) and after fMLP stimulation (P &lt; 0.05), but only at uraemic concentrations in the high range (400 and 1400 pg/mL).	ros	157-160	tumor necrosis factor	Homo sapiens	140-148
25609738-11	2015	ROS production induced by TNFalpha (400 pg/mL) and the cytokine combination was blocked with Ada.	ros	0-3	tumor necrosis factor	Homo sapiens	26-34
26106522-6	2015	These results show that HA might contribute to ROS reduction through Nrf2 regulation by activating Akt.	ros	47-50	NFE2 like bZIP transcription factor 2	Bos taurus	69-73
25694484-6	2015	ANG II also increased renal production of ROS and urinary excretion of thiobarburic acid-reactive substances and reduced the activity of antioxidants and urinary excretion of nitrite/nitrate and the 17beta-estradiol metabolite 2-methoxyestradiol in Cyp1b1(-/-) but not Cyp1b1(+/+) mice.	ros	42-45	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
26078725-10	2015	ROS scavenger N-acetyl-L-cysteine (NAC) blocked the autophagy process induced by 5cGy alpha particle, the upregulation of Nrf2 and HO-1, as well as the induced radio-resistance.	ros	0-3	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
26078725-11	2015	In conclusion, ROS elevation caused by LDIR promoted Autophagy/Nrf2-HO-1 and conferred radio-resistance in A549.	ros	15-18	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	NFE2 like bZIP transcription factor 2	Homo sapiens	139-161
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	NFE2 like bZIP transcription factor 2	Homo sapiens	163-167
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	NAD(P)H quinone dehydrogenase 1	Homo sapiens	199-232
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	NAD(P)H quinone dehydrogenase 1	Homo sapiens	234-238
25724548-0	2015	Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling.	ros	90-93	mitogen-activated protein kinase 1	Homo sapiens	94-97
25724548-6	2015	Specifically, we demonstrated that benzo[a]pyrene enhances breast cancer cell migration and invasion by up-regulating ROS-induced ERK signaling, leading to the activation of matrix metalloproteinases 9.	ros	118-121	mitogen-activated protein kinase 1	Homo sapiens	130-133
25724548-7	2015	Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway.	ros	197-200	mitogen-activated protein kinase 1	Homo sapiens	201-204
26078795-8	2015	Meanwhile, intracellular ROS level was found augmented in HepG2 treated with TRAM-34.	ros	25-28	translocation associated membrane protein 1	Homo sapiens	77-81
25839662-2	2015	Thioredoxin binding protein (TXNIP), the endogenous inhibitor of ROS elimination, has been identified as a tumor suppressor in various solid tumors.	ros	65-68	thioredoxin interacting protein	Homo sapiens	0-27
25839662-2	2015	Thioredoxin binding protein (TXNIP), the endogenous inhibitor of ROS elimination, has been identified as a tumor suppressor in various solid tumors.	ros	65-68	thioredoxin interacting protein	Homo sapiens	29-34
25639646-7	2015	In the presence of TNF-alpha, NLRX1 and active subunits of Caspase-8 are preferentially localized to mitochondria and regulate the mitochondrial ROS generation.	ros	145-148	tumor necrosis factor	Mus musculus	19-28
25804308-7	2015	Intriguingly, ROS scavengers but not AT2R antagonist prevented Ang II-activation of eNOS.	ros	14-17	nitric oxide synthase 3	Homo sapiens	84-88
25804308-11	2015	Taken together, we demonstrate, for the first time, that Ang II upregulates nNOS protein expression and activity via AT1R/ROS/eNOS-dependent S-nitrosation and membrane translocation of AT2R.	ros	122-125	nitric oxide synthase 3	Homo sapiens	126-130
25795137-0	2015	Indole-3-carbinol as inhibitors of glucocorticoid-induced apoptosis in osteoblastic cells through blocking ROS-mediated Nrf2 pathway.	ros	107-110	NFE2 like bZIP transcription factor 2	Homo sapiens	120-124
25795137-7	2015	Excess intracellular ROS induced by Dex significantly suppressed the expression levels of Nrf2 and the downstream effectors, HO1 and NQO1, but these changes could be reversed by I3C.	ros	21-24	NFE2 like bZIP transcription factor 2	Homo sapiens	90-94
25795137-7	2015	Excess intracellular ROS induced by Dex significantly suppressed the expression levels of Nrf2 and the downstream effectors, HO1 and NQO1, but these changes could be reversed by I3C.	ros	21-24	NAD(P)H quinone dehydrogenase 1	Homo sapiens	133-137
25795137-8	2015	Knockdown of Nrf2 using siRNA silencing technique significantly reversed the protective effects of I3C against Dex-induced apoptosis and ROS generation.	ros	137-140	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
25639646-7	2015	In the presence of TNF-alpha, NLRX1 and active subunits of Caspase-8 are preferentially localized to mitochondria and regulate the mitochondrial ROS generation.	ros	145-148	NLR family member X1	Mus musculus	30-35
24898407-6	2015	The antioxidant ability in plasma and heart tissues which was detected by the ferric reducing/antioxidant power assay was also decreased with the increased ROS production under humid heat stress, as was the expression of antioxidant genes (SOD2, HO-1, GPx).	ros	156-159	superoxide dismutase 2, mitochondrial	Mus musculus	240-244
25539708-6	2015	Moreover, we found that pretreatment with NAC markedly inhibited the expression levels of c-FLIP, Mcl-1, and Bcl-2 downregulated by the combinatory treatment, suggesting that the regulating effect of EGCG on these above apoptosis-relevant molecules was partially mediated by generation of ROS.	ros	289-292	CASP8 and FADD like apoptosis regulator	Homo sapiens	90-96
25539708-6	2015	Moreover, we found that pretreatment with NAC markedly inhibited the expression levels of c-FLIP, Mcl-1, and Bcl-2 downregulated by the combinatory treatment, suggesting that the regulating effect of EGCG on these above apoptosis-relevant molecules was partially mediated by generation of ROS.	ros	289-292	BCL2 apoptosis regulator	Homo sapiens	109-114
25797136-14	2015	Activated IKKbeta kinase inhibits ERK1/2 and results in concomitant downstream inhibition of NADPH oxidase complex which can account for sustained impaired production of ROS in HF patients.	ros	170-173	mitogen-activated protein kinase 3	Homo sapiens	34-40
25770995-6	2015	Upon radiation, SeC@MSNs-Tf/TAT promoted intracellular ROS overproduction, which induced apoptotic cell death by affecting p53, AKT and MAPKs pathways.	ros	55-58	thymoma viral proto-oncogene 1	Mus musculus	128-131
25587046-10	2015	In an in vivo model of intimal hyperplasia, transgenic mice expressing DLP1-K38A displayed markedly reduced ROS levels and neointima formation in response to femoral artery wire injury.	ros	108-111	dynamin 1-like	Mus musculus	71-75
24898407-6	2015	The antioxidant ability in plasma and heart tissues which was detected by the ferric reducing/antioxidant power assay was also decreased with the increased ROS production under humid heat stress, as was the expression of antioxidant genes (SOD2, HO-1, GPx).	ros	156-159	heme oxygenase 1	Mus musculus	246-250
25848047-8	2015	Direct down-regulation of PEX13 by RNAi induced the activation of Smad-dependent TGF-beta signaling accompanied by increased ROS production and resulted in the release of cytokines (e.g., IL-6, TGF-beta) and excessive production of collagen I and III.	ros	125-128	peroxisomal biogenesis factor 13	Homo sapiens	26-31
25968268-0	2015	Synergistic effects of particulate matter (PM10) and SO2 on human non-small cell lung cancer A549 via ROS-mediated NF-kappaB activation.	ros	102-105	nuclear factor kappa B subunit 1	Homo sapiens	115-124
25968268-5	2015	Also, radical oxygen species (ROS) production followed by nuclear factor kappa B (NF-kappaB) activation was involved in the above synergistic cytotoxicity, which was confirmed by the repression of the actions by an ROS inhibitor (NAC).	ros	215-218	nuclear factor kappa B subunit 1	Homo sapiens	58-80
25968268-5	2015	Also, radical oxygen species (ROS) production followed by nuclear factor kappa B (NF-kappaB) activation was involved in the above synergistic cytotoxicity, which was confirmed by the repression of the actions by an ROS inhibitor (NAC).	ros	215-218	nuclear factor kappa B subunit 1	Homo sapiens	82-91
25758431-8	2015	In vitro, either pharmacological inhibition of EGFR/AKT or sh-RNA silencing of EGFR significantly inhibited high concentration glucose (HG)-induced ROS generation and subsequently cell apoptosis in both cardiac H9C2 cells and primary rat cardiomyocytes, respectively.	ros	148-151	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
25691377-13	2015	In later stages, the uncontrolled metals and ROS are compounded by other factors which together overcome this BACE1/beta-amyloid protein countermeasure.	ros	45-48	beta-secretase 1	Homo sapiens	110-115
26137629-11	2015	CONCLUSION: Long-term exposure to low concentrations of inorganic arsenic-induced malignant transformation of HaCaT cells is accompanied by intracellular imbalance between oxidative-antioxidant, which increased expression of SOD and low levels of ROS found in the later-stage of arsenite-induced transformation.	ros	247-250	superoxide dismutase 1	Homo sapiens	225-228
25909160-5	2015	Also, IL-32alpha increased ROS production to induce prolonged JNK activation.	ros	27-30	mitogen-activated protein kinase 8	Homo sapiens	62-65
25682038-7	2015	Urea-induced ROS caused the activation of endothelial pro-inflammatory pathways through the inhibition of GAPDH, including increased protein kinase C isoforms activity, increased hexosamine pathway activity, and accumulation of intracellular AGEs (advanced glycation end products).	ros	13-16	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	106-111
25704631-4	2015	As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity.	ros	21-24	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	3-9
25704631-4	2015	As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity.	ros	21-24	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	71-77
25704631-4	2015	As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity.	ros	21-24	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	71-77
25704631-4	2015	As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity.	ros	86-89	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	3-9
25704631-4	2015	As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity.	ros	86-89	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	71-77
25704631-4	2015	As CYP2E1 is a known ROS generating enzyme, we chose HepG2 to minimize CYP2E1-induced ROS formation, which will help us better understand the APAP induced mitochondrial-specific hepatotoxicity in a subpopulation with low CYP2E1 activity.	ros	86-89	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	71-77
25832424-0	2015	C-reactive protein stimulates RAGE expression in human coronary artery endothelial cells in vitro via ROS generation and ERK/NF-kappaB activation.	ros	102-105	C-reactive protein	Homo sapiens	0-18
25832424-6	2015	RESULTS: CRP stimulated the expression of RAGE in the cells, accompanied by markedly increased ROS generation, phosphorylation of ERK1/2 and NF-kappaB p65, as well as translocation of NF-kappaB p65 to the nuclei.	ros	95-98	C-reactive protein	Homo sapiens	9-12
25832424-8	2015	Pretreatment of the cells with the ROS scavenger N-acetyl-L-cysteine, ERK inhibitor PD98059 or NF-kappaB inhibitor PDTC blocked CRP-stimulated RAGE expression, but pretreatment with the NADPH oxidase inhibitor DPI, JNK inhibitor SP600125 or p38 MAPK inhibitor SB203580 did not significantly alter CRP-stimulated RAGE expression.	ros	35-38	C-reactive protein	Homo sapiens	128-131
25832424-8	2015	Pretreatment of the cells with the ROS scavenger N-acetyl-L-cysteine, ERK inhibitor PD98059 or NF-kappaB inhibitor PDTC blocked CRP-stimulated RAGE expression, but pretreatment with the NADPH oxidase inhibitor DPI, JNK inhibitor SP600125 or p38 MAPK inhibitor SB203580 did not significantly alter CRP-stimulated RAGE expression.	ros	35-38	mitogen-activated protein kinase 8	Homo sapiens	215-218
25832424-8	2015	Pretreatment of the cells with the ROS scavenger N-acetyl-L-cysteine, ERK inhibitor PD98059 or NF-kappaB inhibitor PDTC blocked CRP-stimulated RAGE expression, but pretreatment with the NADPH oxidase inhibitor DPI, JNK inhibitor SP600125 or p38 MAPK inhibitor SB203580 did not significantly alter CRP-stimulated RAGE expression.	ros	35-38	C-reactive protein	Homo sapiens	297-300
25832424-9	2015	CONCLUSION: CRP stimulates RAGE expression in HCAECs in vitro via ROS generation and activation of the ERK/NF-kappaB signaling pathway.	ros	66-69	C-reactive protein	Homo sapiens	12-15
25484314-0	2015	Nrf2 regulates ROS production by mitochondria and NADPH oxidase.	ros	15-18	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
25484314-5	2015	RESULTS: We here show that ROS production in Nrf2-KO cells and tissues is increased compared to their WT counterparts.	ros	27-30	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
25484314-6	2015	Mitochondrial ROS production is regulated by the Keap1-Nrf2 pathway by controlling mitochondrial bioenergetics.	ros	14-17	kelch like ECH associated protein 1	Homo sapiens	49-54
25484314-6	2015	Mitochondrial ROS production is regulated by the Keap1-Nrf2 pathway by controlling mitochondrial bioenergetics.	ros	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
25484314-7	2015	Surprisingly, Keap1-KD cells and tissues also showed higher rates of ROS production when compared to WT, although with a smaller magnitude.	ros	69-72	kelch like ECH associated protein 1	Homo sapiens	14-19
25484314-8	2015	Analysis of the mRNA expression levels of the two NOX isoforms implicated in brain pathology showed, that NOX2 is dramatically upregulated under conditions of Nrf2 deficiency, whereas NOX4 is upregulated when Nrf2 is constitutively activated (Keap1-KD) to a degree which paralleled the increases in ROS production.	ros	299-302	NFE2 like bZIP transcription factor 2	Homo sapiens	159-163
25484314-9	2015	CONCLUSIONS: These observations suggest that the Keap1-Nrf2 pathway regulates both mitochondrial and cytosolic ROS production through NADPH oxidase.	ros	111-114	kelch like ECH associated protein 1	Homo sapiens	49-54
25484314-9	2015	CONCLUSIONS: These observations suggest that the Keap1-Nrf2 pathway regulates both mitochondrial and cytosolic ROS production through NADPH oxidase.	ros	111-114	NFE2 like bZIP transcription factor 2	Homo sapiens	55-59
25682038-8	2015	Urea-induced ROS directly inactivated the anti-atherosclerosis enzyme PGI2 synthase and also caused ER stress.	ros	13-16	prostaglandin I receptor (IP)	Mus musculus	70-74
27509686-5	2015	This leads to an increase of ROS production which in turn could regulate signaling pathways sensitive to oxidative stress such as gene-encoding matrix metalloproteases MMP1, MMP13 and Adamalysin ADAMTS4.	ros	29-32	matrix metallopeptidase 13	Homo sapiens	174-179
25649767-8	2015	CYP3A5-induced ROS accumulation was found to be a critical upstream regulator of mTORC2 activity, consistent with evidence of reduced GSH redox activity in most clinical HCC specimens with reduced metastatic capacity.	ros	15-18	cytochrome P450 family 3 subfamily A member 5	Homo sapiens	0-6
29213950-3	2015	Insulin/insulin-like growth factor (IGF) resistance can contribute to neurodegeneration by several mechanisms which involve: energy and metabolism deficits, impairment of Glucose transporter-4 function, oxidative and endoplasmic reticulum stress, mitochondrial dysfunction, accumulation of AGEs, ROS and RNS with increased production of neuro-inflammation and activation of pro-apoptosis cascade.	ros	296-299	insulin	Homo sapiens	0-7
29213950-3	2015	Insulin/insulin-like growth factor (IGF) resistance can contribute to neurodegeneration by several mechanisms which involve: energy and metabolism deficits, impairment of Glucose transporter-4 function, oxidative and endoplasmic reticulum stress, mitochondrial dysfunction, accumulation of AGEs, ROS and RNS with increased production of neuro-inflammation and activation of pro-apoptosis cascade.	ros	296-299	insulin	Homo sapiens	8-15
25580737-6	2015	ROS production was measured in normal and CDH PAECs with and without ET-1 siRNA.	ros	0-3	endothelin-1	Ovis aries	69-73
25399916-5	2015	Excessive amounts of ROS production and changes in mitochondrial membrane potential were prevented by Drp1 inhibition under Ang II and H2 O2 .	ros	21-24	angiotensinogen	Rattus norvegicus	124-130
25655933-0	2015	FoxO3a suppresses the senescence of cardiac microvascular endothelial cells by regulating the ROS-mediated cell cycle.	ros	94-97	forkhead box O3	Homo sapiens	0-6
25655933-4	2015	Furthermore, the activation of the antioxidant enzymes catalase and SOD, downstream FoxO3a targets, was significantly decreased, thereby leading to cell cycle arrest in G1-phase by increased ROS generation and subsequently the activation of the p27(Kip1) pathway.	ros	191-194	forkhead box O3	Homo sapiens	84-90
25655933-5	2015	However, FoxO3a overexpression in primary low-passage CMECs not only significantly suppressed the senescence process by increasing the activation of catalase and SOD but also markedly inhibited ROS generation and p27(Kip1) activation, although it failed to reverse cellular senescence.	ros	194-197	forkhead box O3	Homo sapiens	9-15
25655933-8	2015	Collectively, our data suggest that FoxO3a suppresses the senescence process in CMECs by regulating the antioxidant/ROS/p27(Kip1) pathways, although it fails to reverse the cellular senescent phenotype.	ros	116-119	forkhead box O3	Homo sapiens	36-42
25359126-0	2015	The Apoptotic Effect of Plant Based Nanosilver in Colon Cancer Cells is a p53 Dependent Process Involving ROS and JNK Cascade.	ros	106-109	tumor protein p53	Homo sapiens	74-77
25359126-5	2015	PD-AgNP-mediated apoptosis in CRCs is a p53 dependent process involving ROS and JNK cascade.	ros	72-75	tumor protein p53	Homo sapiens	40-43
25774506-8	2015	Moreover, BMP activation increased intracellular ROS levels, initiating an NRF2-mediated oxidative response during basal progenitor cell differentiation.	ros	49-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	75-79
25580737-11	2015	ROS production was increased in CDH PAEC and decreased with ET-1 SiRNA.	ros	0-3	endothelin-1	Ovis aries	60-64
25580737-13	2015	CONCLUSION: PAEC dysfunction in experimental CDH increases SMC proliferation via ET-1 induced ROS production by PAEC.	ros	94-97	endothelin-1	Ovis aries	81-85
25711811-7	2015	However, AIR12-overexpressing plants accumulated ROS (superoxide, hydrogen peroxide) and lipid peroxides in leaves, indicating that AIR12 may alter the redox state of the apoplast under particular conditions.	ros	49-52	auxin-induced in root cultures-like protein	Arabidopsis thaliana	9-14
25714028-2	2015	p62 induced phase II detoxification enzyme NADPH quinone oxidoreductase 1 (NQO1), which decreased ROS levels and cell migration.	ros	98-101	NAD(P)H quinone dehydrogenase 1	Homo sapiens	43-73
25684043-4	2015	Upon exposure to quinacrine, ROS-mediated p38 MAPK activation and ERK inactivation were observed in K562 cells.	ros	29-32	mitogen-activated protein kinase 14	Homo sapiens	42-45
25684043-4	2015	Upon exposure to quinacrine, ROS-mediated p38 MAPK activation and ERK inactivation were observed in K562 cells.	ros	29-32	mitogen-activated protein kinase 1	Homo sapiens	46-50
25822711-6	2015	Amongst ROS genes, expression of Manganese Superoxide Dismutase (MnSOD) specifically relied on STAT3 signaling as evidenced by STAT3 inhibition and reporter assay.	ros	8-11	superoxide dismutase 2, mitochondrial	Mus musculus	33-63
25822711-6	2015	Amongst ROS genes, expression of Manganese Superoxide Dismutase (MnSOD) specifically relied on STAT3 signaling as evidenced by STAT3 inhibition and reporter assay.	ros	8-11	superoxide dismutase 2, mitochondrial	Mus musculus	65-70
25822711-6	2015	Amongst ROS genes, expression of Manganese Superoxide Dismutase (MnSOD) specifically relied on STAT3 signaling as evidenced by STAT3 inhibition and reporter assay.	ros	8-11	signal transducer and activator of transcription 3	Mus musculus	95-100
25798846-5	2015	Additionally, elevated mitochondrial ROS level, colocalization of NLRP3/ASC/mitochondria in peripheral blood mononuclear cells from CKD-HD patients and down-regulation of CASP-1, IL1-beta and IL-18 protein levels in immune-cells of CKD-HD patients stimulated with LPS/ATP in presence of mitoTEMPO, inhibitor of mitochondrial ROS production, suggested a possible role of this organelle in the aforementioned CKD-associated inflammasome activation.	ros	325-328	caspase 1	Homo sapiens	171-177
25714028-2	2015	p62 induced phase II detoxification enzyme NADPH quinone oxidoreductase 1 (NQO1), which decreased ROS levels and cell migration.	ros	98-101	NAD(P)H quinone dehydrogenase 1	Homo sapiens	75-79
25809610-11	2015	Hyperoxia increased mitochondrial ROS in SOD2+/+ and SOD2-/+ PASMC.	ros	34-37	superoxide dismutase 2, mitochondrial	Mus musculus	41-45
25809610-11	2015	Hyperoxia increased mitochondrial ROS in SOD2+/+ and SOD2-/+ PASMC.	ros	34-37	superoxide dismutase 2, mitochondrial	Mus musculus	53-57
25588103-4	2015	After pretreatment at the concentrations of 5 and 10 muM, oxyresveratrol increased cell viability, exhibited significant suppressions on UVA- or H2O2-induced cellular ROS.	ros	167-170	latexin	Homo sapiens	53-56
25890231-9	2015	Cell apoptosis here is induced by following the ROS-mediated mitochondrial pathway, combined with downregulation of the expression levels of mRNA of XIAP and PARP-1 and upregulation of caspase3, Bcl-2 and Bcl-xL.	ros	48-51	poly(ADP-ribose) polymerase 1	Homo sapiens	158-164
25677663-5	2015	Cytotoxicity studies and determination of superoxide (O2(-)) production in the presence and absence of the NOQ1 inhibitor dicoumarol confirmed that the ortho-quinones exerted their antitumor activity through NQO1-mediated ROS production by redox cycling.	ros	222-225	NAD(P)H quinone dehydrogenase 1	Homo sapiens	208-212
25774669-0	2015	Down-regulation of deacetylase HDAC6 inhibits the melanoma cell line A375.S2 growth through ROS-dependent mitochondrial pathway.	ros	92-95	histone deacetylase 6	Homo sapiens	31-36
25774669-7	2015	Knockdown of HDAC6 triggered a significant generation of ROS and disruption of mitochondrial membrane potential (MMP).	ros	57-60	histone deacetylase 6	Homo sapiens	13-18
25774669-8	2015	Furthermore, ROS inhibitor, NAC reduced HDAC6 siRNA-induced ROS production, and blocked HDAC6 siRNA-induced loss of MMP and apoptosis.	ros	13-16	histone deacetylase 6	Homo sapiens	40-45
25774669-8	2015	Furthermore, ROS inhibitor, NAC reduced HDAC6 siRNA-induced ROS production, and blocked HDAC6 siRNA-induced loss of MMP and apoptosis.	ros	13-16	histone deacetylase 6	Homo sapiens	88-93
25774669-8	2015	Furthermore, ROS inhibitor, NAC reduced HDAC6 siRNA-induced ROS production, and blocked HDAC6 siRNA-induced loss of MMP and apoptosis.	ros	60-63	histone deacetylase 6	Homo sapiens	40-45
25774669-10	2015	In conclusion, the results showed that knockdown of HDAC6 induced apoptosis in human melanoma A375.S2 cells through a ROS-dependent mitochondrial pathway.	ros	118-121	histone deacetylase 6	Homo sapiens	52-57
25890231-9	2015	Cell apoptosis here is induced by following the ROS-mediated mitochondrial pathway, combined with downregulation of the expression levels of mRNA of XIAP and PARP-1 and upregulation of caspase3, Bcl-2 and Bcl-xL.	ros	48-51	caspase 3	Homo sapiens	185-193
25890231-9	2015	Cell apoptosis here is induced by following the ROS-mediated mitochondrial pathway, combined with downregulation of the expression levels of mRNA of XIAP and PARP-1 and upregulation of caspase3, Bcl-2 and Bcl-xL.	ros	48-51	BCL2 apoptosis regulator	Homo sapiens	195-200
25890231-9	2015	Cell apoptosis here is induced by following the ROS-mediated mitochondrial pathway, combined with downregulation of the expression levels of mRNA of XIAP and PARP-1 and upregulation of caspase3, Bcl-2 and Bcl-xL.	ros	48-51	BCL2 like 1	Homo sapiens	205-211
25140833-5	2015	In this report, we show that the E3 ubiquitin ligase, c-CBL, is overexpressed in CTCL and that its knockdown overcomes defective TCR signaling, resulting in phosphorylation of PLC-g1, calcium influx, ROS generation, upregulation of FASL, and extrinsic pathway apoptosis in CTCL cells expressing adequate FAS.	ros	200-203	TSPY like 2	Homo sapiens	81-85
25619389-0	2015	Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways.	ros	124-127	mitogen-activated protein kinase 14	Homo sapiens	128-131
25776488-0	2015	Podophyllotoxin acetate enhances gamma-ionizing radiation-induced apoptotic cell death by stimulating the ROS/p38/caspase pathway.	ros	106-109	mitogen-activated protein kinase 14	Homo sapiens	110-113
25776488-7	2015	Combination with PA and IR also increased the production of ROS, which subsequently induced phosphorylation of p38, suppressed phosphorylation of ERK, and activated caspase-3, -8, and -9.	ros	60-63	mitogen-activated protein kinase 14	Homo sapiens	111-114
25776488-7	2015	Combination with PA and IR also increased the production of ROS, which subsequently induced phosphorylation of p38, suppressed phosphorylation of ERK, and activated caspase-3, -8, and -9.	ros	60-63	mitogen-activated protein kinase 1	Homo sapiens	146-149
25776488-7	2015	Combination with PA and IR also increased the production of ROS, which subsequently induced phosphorylation of p38, suppressed phosphorylation of ERK, and activated caspase-3, -8, and -9.	ros	60-63	caspase 3	Homo sapiens	165-186
25776488-8	2015	Notably, inhibition of ROS production prevented p38 phosphorylation, and inhibition of ROS production or p38 activation blocked caspase activation and apoptosis.	ros	23-26	mitogen-activated protein kinase 14	Homo sapiens	48-51
25619389-11	2015	CONCLUSION: Piperlongumine induces apoptotic and autophagic death of the primary myeloid leukemia cells from patients via activation of ROS-p38/JNK pathways.	ros	136-139	mitogen-activated protein kinase 14	Homo sapiens	140-143
25619390-0	2015	Matrine pretreatment improves cardiac function in rats with diabetic cardiomyopathy via suppressing ROS/TLR-4 signaling pathway.	ros	100-103	toll-like receptor 4	Rattus norvegicus	104-109
25619390-13	2015	CONCLUSION: Excessive ROS production in DCM activates the TLR-4/MyD-88 signaling, resulting in cardiomyocyte apoptosis, whereas pretreatment with matrine improves cardiac function via suppressing ROS/TLR-4 signaling pathway.	ros	22-25	toll-like receptor 4	Rattus norvegicus	58-63
25672415-2	2015	We recently reported that ROS-mediated oxidative stress promotes phosphorylation of endogenous SHP-2 in astrocytes and complex formation between caveolin-1 and SHP-2 in response to oxidative stress.	ros	26-29	caveolin 1	Homo sapiens	145-155
25672415-5	2015	Moreover, deletion of the N-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes.	ros	314-317	caveolin 1	Homo sapiens	221-231
25672415-5	2015	Moreover, deletion of the N-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes.	ros	314-317	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	269-272
25537301-9	2015	Moreover, studies also found that ROS acted as an upstream mediator in NB/BDCur-induced HepG2 cell growth inhibition and led to DNA damage with up-regulation of the expression level of phosphorylated ATM and p53.	ros	34-37	tumor protein p53	Homo sapiens	208-211
25662537-6	2015	The results showed that, in the presence of PMA, zinc treatment leads to reduce the production of ROS, which results in decrease of COX-2 expression and PGE2 release.	ros	98-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	132-137
25180937-10	2015	As PD98059 could not abolish the increment of ROS induced by CPF, we concluded that ERK1/2 phosphorylation is subsequent to ROS production induced by CPF but not the inverse.	ros	124-127	mitogen-activated protein kinase 3	Homo sapiens	84-90
25506723-6	2015	We also found that TNFalpha and IL-13 induce reactive oxidant species (ROS) formation and endoplasmic/sarcoplasmic reticulum (ER/SR) stress (unfolded protein response) in hASM.	ros	71-74	tumor necrosis factor	Homo sapiens	19-27
25506723-6	2015	We also found that TNFalpha and IL-13 induce reactive oxidant species (ROS) formation and endoplasmic/sarcoplasmic reticulum (ER/SR) stress (unfolded protein response) in hASM.	ros	71-74	interleukin 13	Homo sapiens	32-37
25506723-8	2015	Thus, in hASM it appears that TNFalpha and IL-13 result in ROS formation leading to ER/SR stress, reduced Mfn2 expression, disruption of mitochondrion-ER/SR coupling, decreased mitochondrial Ca(2+) buffering, mitochondrial fragmentation, and increased cell proliferation.	ros	59-62	tumor necrosis factor	Homo sapiens	30-38
25506723-8	2015	Thus, in hASM it appears that TNFalpha and IL-13 result in ROS formation leading to ER/SR stress, reduced Mfn2 expression, disruption of mitochondrion-ER/SR coupling, decreased mitochondrial Ca(2+) buffering, mitochondrial fragmentation, and increased cell proliferation.	ros	59-62	interleukin 13	Homo sapiens	43-48
25262983-8	2015	HT-29 cells after treatment with 4 (1-25 muM) revealed ~2.5- 3- folds generation of ROS.	ros	84-87	latexin	Homo sapiens	41-44
25228148-9	2015	This effect was associated with elevated SIRT1 protein expression and antioxidant enzyme activities, resulting in increased mitochondrial respiratory chain activities and decreased ROS level.	ros	181-184	sirtuin 1	Rattus norvegicus	41-46
25434832-5	2015	HMGB1-triggered cell death is associated with intracellular ROS release, and overexpression of Bcl-2 blocks both the increase of ROS as well as HMGB1-dependent cell death.	ros	129-132	BCL2 apoptosis regulator	Homo sapiens	95-100
25449783-9	2015	These findings revealed that a hypoxia-ROS-IL-32beta-Src-glycolysis pathway is associated with the regulation of cancer cell metabolism.	ros	39-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	53-56
26103722-3	2015	However, cellular evolution has made possible the development of adaptive antioxidant systems that scavenge excessive ROS, such as Nrf2/Keapl-ARE, PPAR-y, SIRT and FOXO, etc.	ros	118-121	NFE2 like bZIP transcription factor 2	Homo sapiens	131-135
25529445-0	2015	Eicosapentaenoic acid (EPA) induced apoptosis in HepG2 cells through ROS-Ca(2+)-JNK mitochondrial pathways.	ros	69-72	mitogen-activated protein kinase 8	Homo sapiens	80-83
25529445-7	2015	It seems that ROS may act as an upstream regulator of EPA-induced [Ca(2+)]c generation, moreover, generation of ROS, overload of mitochondrial [Ca(2+)]c, and JNK activated cause the opening of MPTP.	ros	14-17	mitogen-activated protein kinase 8	Homo sapiens	158-161
25529445-8	2015	Western blotting results showed that EPA elevated the phosphorylation status of JNK, processes associated with the ROS generation.	ros	115-118	mitogen-activated protein kinase 8	Homo sapiens	80-83
25529445-10	2015	These results suggest that EPA induces apoptosis through ROS-Ca(2+)-JNK mitochondrial pathways.	ros	57-60	mitogen-activated protein kinase 8	Homo sapiens	68-71
25192797-8	2015	The activation of Nrf2-ARE pathway by PD eventually led to the quenching of ROS overproduction sharply boosted by AGEs.	ros	76-79	NFE2 like bZIP transcription factor 2	Rattus norvegicus	18-22
25377088-0	2015	Loss of mitochondrial exo/endonuclease EXOG affects mitochondrial respiration and induces ROS-mediated cardiomyocyte hypertrophy.	ros	90-93	exo/endonuclease G	Rattus norvegicus	39-43
25377088-14	2015	In conclusion, loss of EXOG affects normal mitochondrial function resulting in increased mitochondrial respiration, excess ROS production, and cardiomyocyte hypertrophy.	ros	123-126	exo/endonuclease G	Rattus norvegicus	23-27
25611379-11	2015	The ROS scavenger also prevented G2/M phase arrest and phosphorylation of JNK.	ros	4-7	mitogen-activated protein kinase 8	Homo sapiens	74-77
25511708-0	2015	Sigma 1 Receptor antagonist potentiates the anti-cancer effect of p53 by regulating ER stress, ROS production, Bax levels, and caspase-3 activation.	ros	95-98	tumor protein p53	Homo sapiens	66-69
26526837-4	2015	Here we report that cytochrome P450-mediated estrogen metabolites produce high ROS concentrations that can result in DNA damage.	ros	79-82	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	20-35
25591955-5	2015	Moreover, treatment of macrophages with 15d-PGJ2, a natural PPAR-gamma ligand, significantly reduced Ang II-induced expression of Egr-1 and its inflammatory gene targets (IL-1beta, TNF-alpha, TGF-beta, MCP-1 and ICAM-1) through PPAR-gamma activation and ROS formation.	ros	254-257	angiotensinogen	Homo sapiens	101-107
25398910-5	2015	This peptide bound in vivo to the extracellular domain of the plasma membrane-localized, atypical leucine-rich repeat receptor-like kinase POLLEN-SPECIFIC RECEPTOR-LIKE KINASE 5 (PRK5) and was sufficient to induce oxidative stress/ROS-dependent cell death.	ros	231-234	Leucine-rich repeat protein kinase family protein	Arabidopsis thaliana	179-183
25728635-0	2015	Nrf2 sensitizes prostate cancer cells to radiation via decreasing basal ROS levels.	ros	72-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
25728635-7	2015	We then found that genetic Nrf2 upregulation lowered basal ROS similar to ADT.	ros	59-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-31
25728635-11	2015	Genetic and pharmaceutical upregulation of Nrf2 lowered the ROS in PCa cells and sensitized PCa cells to radiation similar to ADT, implicating possible administration of SFN in place of ADT for PCa patients requiring radiotherapy.	ros	60-63	NFE2 like bZIP transcription factor 2	Homo sapiens	43-47
25791820-0	2015	Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways.	ros	101-104	mitogen-activated protein kinase 8	Homo sapiens	105-108
25791820-0	2015	Synergistic anticancer potential of dichloroacetate and estradiol analogue exerting their effect via ROS-JNK-Bcl-2-mediated signalling pathways.	ros	101-104	BCL2 apoptosis regulator	Homo sapiens	109-114
25791820-12	2015	Antimitotic compound C9 in combination with a glycolytic inhibitor dichloroacetate eradicates breast cancer cells through ROS-JNK-Bcl-2-mediated signalling pathways in vitro and it is argued that autophagy acts as protective mechanism in the treated cells before apoptosis occurs.	ros	122-125	mitogen-activated protein kinase 8	Homo sapiens	126-129
25791820-12	2015	Antimitotic compound C9 in combination with a glycolytic inhibitor dichloroacetate eradicates breast cancer cells through ROS-JNK-Bcl-2-mediated signalling pathways in vitro and it is argued that autophagy acts as protective mechanism in the treated cells before apoptosis occurs.	ros	122-125	BCL2 apoptosis regulator	Homo sapiens	130-135
26279425-1	2015	BACKGROUND: Angiotensin II/Angiotensin II type 1 receptor (AT1R) effects are dependent on ROS production stimulated by NADPH oxidase activation.	ros	90-93	angiotensinogen	Homo sapiens	12-26
26279425-8	2015	Hsp72 knockdown resulted in enhanced Nox4 protein levels, NADPH oxidase activity and ROS generation in (L+AII) revealing that Losartan was unable to abrogate AII effects on Nox4 expression and oxidative activity.	ros	85-88	heat shock protein family A (Hsp70) member 1A	Homo sapiens	0-5
25929862-5	2015	The primary purpose of this review is to introduce the studies of the signaling mechanisms of IR in NF-kappaB activation, such as ROS/NF-kappaB, ATM or DNA-PK/MAPKK/ p90rsk, PI3K/AKT/IKK and k-ras/c-raf/ MEKK/ NF-kappaB pathways.	ros	130-133	nuclear factor kappa B subunit 1	Homo sapiens	100-109
26391545-5	2015	The UPP inhibitor and UbshRNA could attenuate these effects through inhibiting the pathway of ROS/PARP and the expression of NF-kappaB inflammatory factors, and the increased UPP was a result of high glucose-induced increase of ROS generation and NF-kappaBp65 expression, accompanied with the decrease of DeltaPsim.	ros	94-97	poly(ADP-ribose) polymerase 1	Homo sapiens	98-102
26391545-5	2015	The UPP inhibitor and UbshRNA could attenuate these effects through inhibiting the pathway of ROS/PARP and the expression of NF-kappaB inflammatory factors, and the increased UPP was a result of high glucose-induced increase of ROS generation and NF-kappaBp65 expression, accompanied with the decrease of DeltaPsim.	ros	228-231	poly(ADP-ribose) polymerase 1	Homo sapiens	98-102
26391545-7	2015	It has been indicated that the pathogenic effect of UPP on DR was involved in the increase of ROS generation and NF-kappaB expression, which associated with the ROS/PARP and NF-kappaB inflammatory factor pathways.	ros	94-97	poly(ADP-ribose) polymerase 1	Homo sapiens	165-169
26391545-7	2015	It has been indicated that the pathogenic effect of UPP on DR was involved in the increase of ROS generation and NF-kappaB expression, which associated with the ROS/PARP and NF-kappaB inflammatory factor pathways.	ros	161-164	poly(ADP-ribose) polymerase 1	Homo sapiens	165-169
26089952-6	2015	High level of ROS was provoked by P2, which was in turn responsible for induction of apoptosis through activation of intrinsic mitochondrial pathway and JNK1/2, p38 MAPK pathways, as well as inhibition of ERK1/2 pathway, as evidenced by the abrogation of P2"s effect on HeLa cells preincubated with the ROS scavenger NAC.	ros	14-17	mitogen-activated protein kinase 8	Homo sapiens	153-159
26089952-6	2015	High level of ROS was provoked by P2, which was in turn responsible for induction of apoptosis through activation of intrinsic mitochondrial pathway and JNK1/2, p38 MAPK pathways, as well as inhibition of ERK1/2 pathway, as evidenced by the abrogation of P2"s effect on HeLa cells preincubated with the ROS scavenger NAC.	ros	14-17	mitogen-activated protein kinase 1	Homo sapiens	161-164
26089952-6	2015	High level of ROS was provoked by P2, which was in turn responsible for induction of apoptosis through activation of intrinsic mitochondrial pathway and JNK1/2, p38 MAPK pathways, as well as inhibition of ERK1/2 pathway, as evidenced by the abrogation of P2"s effect on HeLa cells preincubated with the ROS scavenger NAC.	ros	14-17	mitogen-activated protein kinase 3	Homo sapiens	165-169
26089952-6	2015	High level of ROS was provoked by P2, which was in turn responsible for induction of apoptosis through activation of intrinsic mitochondrial pathway and JNK1/2, p38 MAPK pathways, as well as inhibition of ERK1/2 pathway, as evidenced by the abrogation of P2"s effect on HeLa cells preincubated with the ROS scavenger NAC.	ros	14-17	mitogen-activated protein kinase 3	Homo sapiens	205-211
25179911-9	2015	Contact site breakage both sensitises the MPTP to [Ca(2+)] and facilitates cytochrome c loss from the intermembrane space leading to greater ROS production and further MPTP opening.	ros	141-144	cytochrome c, somatic	Homo sapiens	75-87
26634216-7	2015	Hydroxy-3-methoxyaceto-phenone (HMAP), diphenyleneiodonium (DPI), and siRNA Nox2 reduced the ROS and IL-8 release in neutrophils treated with fMLP.	ros	93-96	formyl peptide receptor 1	Homo sapiens	142-146
26634216-10	2015	We showed that IL-8 release induced by fMLP is dependent on NADPH oxidase, and ROS could play a redundant role in cell signalling, ultimately activating the PI3K/Akt and NF-kappaB pathways in neutrophils.	ros	79-82	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
26634216-10	2015	We showed that IL-8 release induced by fMLP is dependent on NADPH oxidase, and ROS could play a redundant role in cell signalling, ultimately activating the PI3K/Akt and NF-kappaB pathways in neutrophils.	ros	79-82	AKT serine/threonine kinase 1	Homo sapiens	162-165
26634216-10	2015	We showed that IL-8 release induced by fMLP is dependent on NADPH oxidase, and ROS could play a redundant role in cell signalling, ultimately activating the PI3K/Akt and NF-kappaB pathways in neutrophils.	ros	79-82	nuclear factor kappa B subunit 1	Homo sapiens	170-179
26180584-6	2015	This decrease seemed to be the main signal responsible for maintaining the intracellular redox homeostasis hindering the activation of p53 induced by ROS, p38MAPK, and PKCdelta.	ros	150-153	tumor protein p53	Homo sapiens	135-138
26029782-6	2015	RESULTS: In NRK-52E cells, AKF-PD reduced AngII induced expressions of ROS, NOX2, fibronectin, collagen I (a1) and p-ERK.	ros	71-74	angiotensinogen	Rattus norvegicus	42-47
25234195-7	2015	Meaningfully, pretreatment of a type of ROS scavenger formulations named N-(mercaptopropionyl)-glycine (N-MPG) could inhibit podocyte apoptosis induced by Ang II.	ros	40-43	angiotensinogen	Homo sapiens	155-161
26078812-4	2015	TGF-beta can control ROS production directly or by downregulating antioxidative systems.	ros	21-24	transforming growth factor beta 1	Homo sapiens	0-8
26078812-5	2015	Meanwhile, ROS can influence TGF-beta signaling and increase its expression as well as its activation from the latent complex.	ros	11-14	transforming growth factor beta 1	Homo sapiens	29-37
26180584-8	2015	Finally, we demonstrated that PCA induced the activation of JNK, which, in turn, determined the increase of nuclear Nrf2, leading to inhibition of the early ROS overproduction.	ros	157-160	mitogen-activated protein kinase 8	Homo sapiens	60-63
26180584-8	2015	Finally, we demonstrated that PCA induced the activation of JNK, which, in turn, determined the increase of nuclear Nrf2, leading to inhibition of the early ROS overproduction.	ros	157-160	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	56-59	tumor protein p53	Homo sapiens	116-119
26583060-11	2015	Overall findings show that hypoxia increases the expression of hCLOCK, which leads to ROS production, which then activates the RhoA and NF-kappaB pathways.	ros	86-89	ras homolog family member A	Homo sapiens	127-131
26583060-12	2015	CONCLUSION: Our findings suggest that hypoxic states induce vascular oxidative damage and inflammation via hCLOCK-mediated production of ROS, with subsequent activation of the RhoA and NF-kappaB pathways.	ros	137-140	ras homolog family member A	Homo sapiens	176-180
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	92-95	tumor protein p53	Homo sapiens	64-67
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	92-95	tumor protein p53	Homo sapiens	116-119
25448047-4	2014	Using chemiluminescence and electron paramagnetic resonance (EPR) spin-trapping techniques, this study for the first time demonstrated the real-time formation of ROS in the redox activation of beta-lapachone from cancer cells mediated by mitochondria and NQO1 in melanoma B16-F10 and hepatocellular carcinoma HepG2 cancer cells.	ros	162-165	NAD(P)H quinone dehydrogenase 1	Homo sapiens	255-259
25638774-13	2015	M.abs infection enhanced THP-1 ROS production as demonstrated by increased DHE, DCF fluorescence, and EPR signal.	ros	31-34	GLI family zinc finger 2	Homo sapiens	25-30
25534001-6	2014	Additionally, we observed that plasma induces ROS, which activated MAPK p38 and inhibits p42/p44 MAPK, leading to cancer cell death.	ros	46-49	mitogen-activated protein kinase 3	Homo sapiens	67-71
25534001-6	2014	Additionally, we observed that plasma induces ROS, which activated MAPK p38 and inhibits p42/p44 MAPK, leading to cancer cell death.	ros	46-49	mitogen-activated protein kinase 14	Homo sapiens	72-75
25534001-6	2014	Additionally, we observed that plasma induces ROS, which activated MAPK p38 and inhibits p42/p44 MAPK, leading to cancer cell death.	ros	46-49	mitogen-activated protein kinase 3	Homo sapiens	93-101
25942647-6	2015	This review summarizes the molecular mechanisms underlying the cross-talk between Rac and PI3K signaling in 2 different processes, cell migration and ROS production.	ros	150-153	AKT serine/threonine kinase 1	Homo sapiens	82-85
25448047-7	2014	These results revealed the differential contribution of METC and NQO1 to beta-lapachone-induced ROS formation and cancer cell killing.	ros	96-99	NAD(P)H quinone dehydrogenase 1	Homo sapiens	65-69
25485873-8	2014	Furthermore, the p26-PARP1 interaction seems to be responsible for the persistence of ROS, and in turn of DSBs, at 24 h from IR.	ros	86-89	poly(ADP-ribose) polymerase 1	Homo sapiens	21-26
29805908-18	2014	Conclusions: The results of our study have indicated that Abeta42 induced accumulation of P-selectin on the surface of bEnd3 cells and promoted actin polymerization, and all these events were correlated with ROS generation.	ros	208-211	selectin, platelet	Mus musculus	90-100
25087850-8	2014	Notably, complex 4 entered the cancer cells partially through transferrin receptor-mediated endocytosis, and then it translocated from lysosomes to the mitochondria, where it activated mitochondrial dysfunction by regulation of Bcl-2 family proteins, thus leading to intracellular ROS overproduction.	ros	281-284	transferrin	Homo sapiens	62-73
25087850-9	2014	Excess ROS amplified apoptotic signals by activating many downstream pathways such as p53 and MAPK pathways to promote cell apoptosis.	ros	7-10	tumor protein p53	Homo sapiens	86-89
24329571-7	2014	In PR patients, the levels of SFV were positively related to TNF-alpha (r = 0.67; P &lt; 0.01), fMLP-stimulated ROS production in the 45% Percoll fraction (r = 0.687, P &lt; 0.01) and the 90% Percoll fraction in basal condition (r = 0.695, P &lt; 0.01), and after fMLP-stimulation (r = 0.688, P &lt; 0.01).	ros	112-115	formyl peptide receptor 1	Homo sapiens	96-100
25218135-5	2014	In VSMCs, CA-PH significantly reduced hydrogen peroxide-induced ROS generation and increased the expression of heme oxygenase-1.	ros	64-67	non-SMC condensin I complex subunit H	Homo sapiens	10-15
25520741-14	2014	CONCLUSIONS: Collectively, our results demonstrated that Bach1 plays an important role in Hcy-triggered ROS generations through inhibiting HO-1 expression, likely, resulting from the disturbed interplay between Bach1 and Nrf2.	ros	104-107	heme oxygenase 1	Mus musculus	139-143
25520741-14	2014	CONCLUSIONS: Collectively, our results demonstrated that Bach1 plays an important role in Hcy-triggered ROS generations through inhibiting HO-1 expression, likely, resulting from the disturbed interplay between Bach1 and Nrf2.	ros	104-107	nuclear factor, erythroid derived 2, like 2	Mus musculus	221-225
25152356-11	2014	Antioxidant activity of tiliroside in BV2 cells was demonstrated through attenuation of LPS+IFNgamma-induced ROS production and activation of HO-1/Nrf2 antioxidant system.	ros	109-112	interferon gamma	Mus musculus	92-100
25308836-8	2014	Scavenging of ROS by antioxidant N-acetyl-cysteine (NAC) inhibited caspase-3 activity and rescued the cells from apoptosis.	ros	14-17	caspase 3	Homo sapiens	67-76
25396430-5	2014	This trend was also observed with each step of the signaling mechanism for IL-1beta production, which is a single pathway affiliated with ROS generation or lysosomal rupture or both, cathepsin B, caspase-1 (NALP3 inflammasome), and finally IL-1beta production in THP-1 cells.	ros	138-141	interleukin 1 beta	Homo sapiens	75-83
25091502-10	2014	CONCLUSIONS AND IMPLICATIONS: ET-1 stimulates ETA -mediated NADPH oxidase-dependent ROS generation, which inhibits endothelial NO bioavailability and contributes to ET-1-induced contraction in healthy penile arteries.	ros	84-87	endothelin 1	Rattus norvegicus	30-34
25091502-10	2014	CONCLUSIONS AND IMPLICATIONS: ET-1 stimulates ETA -mediated NADPH oxidase-dependent ROS generation, which inhibits endothelial NO bioavailability and contributes to ET-1-induced contraction in healthy penile arteries.	ros	84-87	endothelin 1	Rattus norvegicus	165-169
25229402-13	2014	In conclusion, our findings demonstrated that Smad3-Nox4 axis-mediated mitochondrial dysfunction is involved in PA-induced podocyte damage likely via increasing ROS generation and activating the cytochrome c-caspase9-caspase3 apoptotic signaling pathway.	ros	161-164	SMAD family member 3	Rattus norvegicus	46-51
25280834-4	2014	We firstly observed that thrombin activated protease-activated receptor 1 (PAR-1) inducing the increases of intracellular Ca(2+) and ROS production, which contribute to the astrocytes" proliferation.	ros	133-136	coagulation factor II, thrombin	Homo sapiens	25-33
25280834-4	2014	We firstly observed that thrombin activated protease-activated receptor 1 (PAR-1) inducing the increases of intracellular Ca(2+) and ROS production, which contribute to the astrocytes" proliferation.	ros	133-136	coagulation factor II thrombin receptor	Homo sapiens	44-73
25280834-4	2014	We firstly observed that thrombin activated protease-activated receptor 1 (PAR-1) inducing the increases of intracellular Ca(2+) and ROS production, which contribute to the astrocytes" proliferation.	ros	133-136	coagulation factor II thrombin receptor	Homo sapiens	75-80
25280834-5	2014	We further confirmed that ROS stabilized HIF-1alpha, the latter subsequently accelerated glucose uptake in astrocytes.	ros	26-29	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
25280834-7	2014	As a result, we discovered three signaling pathways mainly accounting for cell proliferation induced by thrombin: (1) thrombin-stimulated ERK, JNK/ROS/HIF-1alpha and (2) PI3K/Akt/ROS/HIF-1alpha pathways to increase expression of hexokinase 2 which mediated glucose metabolism in astrocytes, and (3) thrombin stimulates PAR-1/PI3K/Akt/cyclin D1 to promote the cell cycle transition and finally to increase cell proliferation.	ros	147-150	coagulation factor II, thrombin	Homo sapiens	104-112
25280834-7	2014	As a result, we discovered three signaling pathways mainly accounting for cell proliferation induced by thrombin: (1) thrombin-stimulated ERK, JNK/ROS/HIF-1alpha and (2) PI3K/Akt/ROS/HIF-1alpha pathways to increase expression of hexokinase 2 which mediated glucose metabolism in astrocytes, and (3) thrombin stimulates PAR-1/PI3K/Akt/cyclin D1 to promote the cell cycle transition and finally to increase cell proliferation.	ros	147-150	coagulation factor II, thrombin	Homo sapiens	118-126
25280834-7	2014	As a result, we discovered three signaling pathways mainly accounting for cell proliferation induced by thrombin: (1) thrombin-stimulated ERK, JNK/ROS/HIF-1alpha and (2) PI3K/Akt/ROS/HIF-1alpha pathways to increase expression of hexokinase 2 which mediated glucose metabolism in astrocytes, and (3) thrombin stimulates PAR-1/PI3K/Akt/cyclin D1 to promote the cell cycle transition and finally to increase cell proliferation.	ros	147-150	coagulation factor II, thrombin	Homo sapiens	118-126
25280834-7	2014	As a result, we discovered three signaling pathways mainly accounting for cell proliferation induced by thrombin: (1) thrombin-stimulated ERK, JNK/ROS/HIF-1alpha and (2) PI3K/Akt/ROS/HIF-1alpha pathways to increase expression of hexokinase 2 which mediated glucose metabolism in astrocytes, and (3) thrombin stimulates PAR-1/PI3K/Akt/cyclin D1 to promote the cell cycle transition and finally to increase cell proliferation.	ros	179-182	coagulation factor II, thrombin	Homo sapiens	104-112
25280834-7	2014	As a result, we discovered three signaling pathways mainly accounting for cell proliferation induced by thrombin: (1) thrombin-stimulated ERK, JNK/ROS/HIF-1alpha and (2) PI3K/Akt/ROS/HIF-1alpha pathways to increase expression of hexokinase 2 which mediated glucose metabolism in astrocytes, and (3) thrombin stimulates PAR-1/PI3K/Akt/cyclin D1 to promote the cell cycle transition and finally to increase cell proliferation.	ros	179-182	coagulation factor II, thrombin	Homo sapiens	118-126
25193743-0	2014	alpha-Lipoic acid protected cardiomyoblasts from the injury induced by sodium nitroprusside through ROS-mediated Akt/Gsk-3beta activation.	ros	100-103	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
25193743-9	2014	Interestingly, inhibition of ROS with N-acetylcysteine abrogated Akt/Gsk-3beta activation and the LA-induced cytoprotection following SNP stimulation.	ros	29-32	AKT serine/threonine kinase 1	Rattus norvegicus	65-68
25193743-10	2014	Taken together, the results indicate that LA protected the SNP-induced injury in cardiac H9c2 cells through, at least in part, the activation of Akt/Gsk-3beta signaling in a ROS-dependent mechanism.	ros	174-177	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
25320841-8	2014	Overall, these findings provide evidence that 1 potentiates TRAIL-mediated apoptosis through up-regulation of DR5 via a ROS-independent pathway.	ros	120-123	TNF superfamily member 10	Homo sapiens	60-65
25280834-7	2014	As a result, we discovered three signaling pathways mainly accounting for cell proliferation induced by thrombin: (1) thrombin-stimulated ERK, JNK/ROS/HIF-1alpha and (2) PI3K/Akt/ROS/HIF-1alpha pathways to increase expression of hexokinase 2 which mediated glucose metabolism in astrocytes, and (3) thrombin stimulates PAR-1/PI3K/Akt/cyclin D1 to promote the cell cycle transition and finally to increase cell proliferation.	ros	179-182	coagulation factor II, thrombin	Homo sapiens	118-126
25134437-0	2014	Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation.	ros	110-113	NFE2 like bZIP transcription factor 2	Homo sapiens	74-79
25134437-0	2014	Cigarette smoke extract-induced BEAS-2B cell apoptosis and anti-oxidative Nrf-2 up-regulation are mediated by ROS-stimulated p38 activation.	ros	110-113	mitogen-activated protein kinase 14	Homo sapiens	125-128
25134437-5	2014	N-acetylcysteine (a general antioxidant) attenuated the CSE-induced ASK-1 and p38 MAPK activation and cell apoptosis, suggesting a triggering role of ROS in ASK-1/p38 MAPK activation during apoptotic progression.	ros	150-153	mitogen-activated protein kinase 14	Homo sapiens	78-81
25134437-5	2014	N-acetylcysteine (a general antioxidant) attenuated the CSE-induced ASK-1 and p38 MAPK activation and cell apoptosis, suggesting a triggering role of ROS in ASK-1/p38 MAPK activation during apoptotic progression.	ros	150-153	mitogen-activated protein kinase 14	Homo sapiens	163-166
25134437-7	2014	Taken together, the data presented in this manuscript demonstrate that the ROS-dependent ASK-1/p38 signaling cascade regulates CSE-induced BEAS-2B cell apoptosis.	ros	75-78	mitogen-activated protein kinase 14	Homo sapiens	95-98
25134437-8	2014	In addition, anti-oxidative Nrf-2 is also up-regulated by the ROS/p38 signaling cascade in this progression.	ros	62-65	NFE2 like bZIP transcription factor 2	Homo sapiens	28-33
25134437-8	2014	In addition, anti-oxidative Nrf-2 is also up-regulated by the ROS/p38 signaling cascade in this progression.	ros	62-65	mitogen-activated protein kinase 14	Homo sapiens	66-69
25065405-0	2014	Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation.	ros	90-93	mitogen-activated protein kinase 1	Homo sapiens	94-97
25162939-8	2014	Moreover, a set of FOXO3-dependent mitochondrial antioxidant enzymes, including manganese superoxide dismutase (MnSOD), peroxiredoxin 3 (Prx3), Prx5 and thioredoxin 2 (Trx2), are up-regulated in ECs to facilitate ROS detoxification in response to hypoxia.	ros	213-216	forkhead box O3	Homo sapiens	19-24
25135223-8	2014	Excessive ROS triggered DNA damage and activated downstream signaling pathways, including the phosphorylation of p53 and p38MAPK, and down-regulation of phosphorylated AKT and ERK, finally resulted in increase of radiosensitivity and inhibition of tumor reproduction.	ros	10-13	tumor protein p53	Homo sapiens	113-116
25135223-8	2014	Excessive ROS triggered DNA damage and activated downstream signaling pathways, including the phosphorylation of p53 and p38MAPK, and down-regulation of phosphorylated AKT and ERK, finally resulted in increase of radiosensitivity and inhibition of tumor reproduction.	ros	10-13	AKT serine/threonine kinase 1	Homo sapiens	168-171
25135223-8	2014	Excessive ROS triggered DNA damage and activated downstream signaling pathways, including the phosphorylation of p53 and p38MAPK, and down-regulation of phosphorylated AKT and ERK, finally resulted in increase of radiosensitivity and inhibition of tumor reproduction.	ros	10-13	mitogen-activated protein kinase 1	Homo sapiens	176-179
25065405-9	2014	In addition, the activation of ROS-ERK pathway by mitochondrial fission induced phosphorylation of serine73 on MITF accelerating its proteasomal degradation.	ros	31-34	mitogen-activated protein kinase 1	Homo sapiens	35-38
25065405-10	2014	In conclusion, mitochondrial dynamics may regulate melanogenesis by modulating ROS-ERK signaling pathway.	ros	79-82	mitogen-activated protein kinase 1	Homo sapiens	83-86
25383959-5	2014	Instead, Celastrol induced the accumulation of the HIF-1alpha protein by inducing ROS and activating Akt/p70S6K signaling to promote HIF-1alpha translation.	ros	82-85	hypoxia inducible factor 1 subunit alpha	Homo sapiens	51-61
25072752-8	2014	ROS production was increased after DHMEQ-Olaparib treatment of Hep3B, which caused DNA damage by an accumulation of gammaH2AX, increased AKT phosphorylation and reduced cell viability.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	137-140
25044446-8	2014	Further, the effects of oxHDL for the enhanced formation of MMP-9 were found to be mediated by NADPH oxidase/ROS-JNK/ERK pathway, as one mechanism.	ros	109-112	mitogen-activated protein kinase 8	Homo sapiens	113-116
25044446-8	2014	Further, the effects of oxHDL for the enhanced formation of MMP-9 were found to be mediated by NADPH oxidase/ROS-JNK/ERK pathway, as one mechanism.	ros	109-112	mitogen-activated protein kinase 1	Homo sapiens	117-120
25065405-3	2014	Here, we show that mitochondrial dynamics regulate melanogenesis by modulating the ROS-ERK signaling pathway.	ros	83-86	mitogen-activated protein kinase 1	Homo sapiens	87-90
25350363-6	2014	The cytotoxic effect of 1 in U87 cells could be related to its ability to provoke the release of ROS, suggesting that the cytotoxicity of 1 might be somehow p53 dependent.	ros	97-100	tumor protein p53	Homo sapiens	157-160
25064608-3	2014	However, the relationship between NADPH oxidase-ROS and JNK MAPK signal still remains unclear.	ros	48-51	mitogen-activated protein kinase 8	Homo sapiens	56-59
25064608-4	2014	Here, we discovered a novel self-driven signal circuit between NADPH oxidase-ROS and JNK MAPK, which was induced by a cytotoxic steroidal saponin (ASC) in hepatoma carcinoma cells.	ros	77-80	mitogen-activated protein kinase 8	Homo sapiens	85-88
25064608-4	2014	Here, we discovered a novel self-driven signal circuit between NADPH oxidase-ROS and JNK MAPK, which was induced by a cytotoxic steroidal saponin (ASC) in hepatoma carcinoma cells.	ros	77-80	PYD and CARD domain containing	Homo sapiens	147-150
25064608-5	2014	NADPH oxidase-dependent ROS production was markedly activated by ASC and directly led to JNK MAPK activation.	ros	24-27	PYD and CARD domain containing	Homo sapiens	65-68
25064608-5	2014	NADPH oxidase-dependent ROS production was markedly activated by ASC and directly led to JNK MAPK activation.	ros	24-27	mitogen-activated protein kinase 8	Homo sapiens	89-92
25064608-6	2014	Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK.	ros	141-144	mitogen-activated protein kinase 8	Homo sapiens	155-158
25064608-6	2014	Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK.	ros	141-144	mitogen-activated protein kinase 8	Homo sapiens	229-232
25064608-7	2014	Conversely, a specific JNK inhibitor could inhibit ASC-induced NADPH oxidase activation and down-regulate ROS levels as well, indicating that JNK might also regulate NADPH oxidase activity to some extent.	ros	106-109	mitogen-activated protein kinase 8	Homo sapiens	23-26
25064608-7	2014	Conversely, a specific JNK inhibitor could inhibit ASC-induced NADPH oxidase activation and down-regulate ROS levels as well, indicating that JNK might also regulate NADPH oxidase activity to some extent.	ros	106-109	PYD and CARD domain containing	Homo sapiens	51-54
25064608-7	2014	Conversely, a specific JNK inhibitor could inhibit ASC-induced NADPH oxidase activation and down-regulate ROS levels as well, indicating that JNK might also regulate NADPH oxidase activity to some extent.	ros	106-109	mitogen-activated protein kinase 8	Homo sapiens	142-145
25064608-10	2014	Taken together, we provide a proof for inducing hepatoma carcinoma cell apoptosis by activating the JNK-NADPH oxidase-ROS-dependent self-driven signal circuit pathway.	ros	118-121	mitogen-activated protein kinase 8	Homo sapiens	100-103
25321472-0	2014	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway.	ros	145-148	TNF superfamily member 10	Homo sapiens	70-75
25341038-9	2014	Using a small-molecule inhibitor of 20S proteasome and ROS-inducer--withaferin A (WA), we found that WA-induced ROS activates JNK kinase and stabilizes phase II anti-oxidant response effector NF-E2-related transcription factor (NRF2).	ros	55-58	mitogen-activated protein kinase 8	Homo sapiens	126-129
25341038-9	2014	Using a small-molecule inhibitor of 20S proteasome and ROS-inducer--withaferin A (WA), we found that WA-induced ROS activates JNK kinase and stabilizes phase II anti-oxidant response effector NF-E2-related transcription factor (NRF2).	ros	112-115	mitogen-activated protein kinase 8	Homo sapiens	126-129
25341038-9	2014	Using a small-molecule inhibitor of 20S proteasome and ROS-inducer--withaferin A (WA), we found that WA-induced ROS activates JNK kinase and stabilizes phase II anti-oxidant response effector NF-E2-related transcription factor (NRF2).	ros	112-115	NFE2 like bZIP transcription factor 2	Homo sapiens	228-232
25321472-9	2014	In conclusion, our results suggest that Med sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the upregulation of DR5 through activation of the ROS-JNK-CHOP pathway.	ros	163-166	mitogen-activated protein kinase 8	Homo sapiens	167-170
25321472-9	2014	In conclusion, our results suggest that Med sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the upregulation of DR5 through activation of the ROS-JNK-CHOP pathway.	ros	163-166	DNA damage inducible transcript 3	Homo sapiens	171-175
25321472-0	2014	Medicarpin, a legume phytoalexin sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the induction of DR5 and activation of the ROS-JNK-CHOP pathway.	ros	145-148	mitogen-activated protein kinase 8	Homo sapiens	149-152
25321472-9	2014	In conclusion, our results suggest that Med sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the upregulation of DR5 through activation of the ROS-JNK-CHOP pathway.	ros	163-166	TNF superfamily member 10	Homo sapiens	81-86
26461402-12	2014	The observed concentration-dependent lowering of the glutathione ratio and increase in intracellular ROS generation corresponded with an increase in Nrf2 transcriptional activation of the ARE.	ros	101-104	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
24933647-5	2014	GADD153, in turn, down-regulated Bcl-2 protein to cause mitochondrial membrane potential loss and apoptosis through intracellular ROS generation.	ros	130-133	B cell leukemia/lymphoma 2	Mus musculus	33-38
25305377-0	2014	Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells.	ros	53-56	mitogen-activated protein kinase 8	Homo sapiens	99-102
25305377-0	2014	Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells.	ros	53-56	AKT serine/threonine kinase 1	Homo sapiens	107-110
25305377-0	2014	Abrus precatorius agglutinin-derived peptides induce ROS-dependent mitochondrial apoptosis through JNK and Akt/P38/P53 pathways in HeLa cells.	ros	53-56	mitogen-activated protein kinase 14	Homo sapiens	111-118
25305377-7	2014	ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	63-66
25305377-7	2014	ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	101-124
25305377-7	2014	ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	126-129
25305377-7	2014	ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	132-168
25305377-7	2014	ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation.	ros	0-3	tumor protein p53	Homo sapiens	177-180
25329652-2	2014	Moreover, Ca2+, ROS and phospholipase A2, in particular iPLA2, are thought to potentiate each other in positive feedback loops.	ros	16-19	phospholipase A2, group VI	Mus musculus	56-61
25010292-9	2014	In addition DNA damage induced ROS generation with simultaneous activation of ATM and ATR upon compound treatment was observed.	ros	31-34	ATR serine/threonine kinase	Homo sapiens	86-89
25005756-3	2014	Recent in vitro studies show that LOX-1 activation by ox-LDL and angiotensin II (Ang II) induces angiogenesis via activation of NADPH oxidase and subsequent increase in ROS production.	ros	169-172	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	65-79
25005756-3	2014	Recent in vitro studies show that LOX-1 activation by ox-LDL and angiotensin II (Ang II) induces angiogenesis via activation of NADPH oxidase and subsequent increase in ROS production.	ros	169-172	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	81-87
25128810-8	2014	Furthermore, inhibiting the Akt/GSK-3beta and ERK1/2 pathway by these inhibitors significantly reversed the hispidin-induced Bax and Bcl-2 expression, apoptosis induction, and ROS production.	ros	176-179	AKT serine/threonine kinase 1	Rattus norvegicus	28-31
26461299-9	2014	Interestingly, the circadian variation in ROS precedes the Nrf2 protein level and the transcript level of proteasome catalytic subunits and activators.	ros	42-45	NFE2 like bZIP transcription factor 2	Homo sapiens	59-63
25046589-5	2014	Next, we found that ROS and TBARS levels were increased in LPS/d-GalN treated liver homogenates, which were attenuated by LA administration.	ros	20-23	galanin and GMAP prepropeptide	Mus musculus	65-69
25270604-13	2014	NHE1 inhibitor cariporide attenuated MG-triggered ROS production, leukocyte adhesion and emigration and microvascular hyperpermeability, without affecting leukocyte rolling.	ros	50-53	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	0-4
25016313-1	2014	Inducible nitric-oxide synthase (iNOS) produces the reactive oxygen and nitrogen species (ROS/RNS) involved in bacteria killing and is crucial in the host defense mechanism.	ros	90-93	nitric oxide synthase 2	Homo sapiens	33-37
25016313-1	2014	Inducible nitric-oxide synthase (iNOS) produces the reactive oxygen and nitrogen species (ROS/RNS) involved in bacteria killing and is crucial in the host defense mechanism.	ros	90-93	nitric oxide synthase 2	Homo sapiens	0-31
25064160-5	2014	Interestingly, quenching of ROS with tiron, an antioxidant, offered significant protection against HC-induced inhibition of cell growth and down regulation of caspase-3, suggesting the crucial role of ROS in mediating cell death.	ros	28-31	caspase 3	Homo sapiens	159-168
25064160-5	2014	Interestingly, quenching of ROS with tiron, an antioxidant, offered significant protection against HC-induced inhibition of cell growth and down regulation of caspase-3, suggesting the crucial role of ROS in mediating cell death.	ros	201-204	caspase 3	Homo sapiens	159-168
25270604-15	2014	CONCLUSION: MG elicits SGK1-dependent activation of endothelial Na+/H+ exchanger NHE1 which participates in MG-induced ROS production, upregulation of endothelial ICAM-1, leukocyte recruitment and microvascular hyperpermeability.	ros	119-122	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	81-85
25547582-9	2014	As the glucose concentration increased and duration prolonged, the expression of anti-apoptotic protein Bcl-2 was decreased and pro-apoptotic protein Bax was increased.Intracellular ROS and MDA induced by high glucose were increased significantly with dose-and time-dependence.	ros	182-185	BCL2 apoptosis regulator	Homo sapiens	104-109
25547582-9	2014	As the glucose concentration increased and duration prolonged, the expression of anti-apoptotic protein Bcl-2 was decreased and pro-apoptotic protein Bax was increased.Intracellular ROS and MDA induced by high glucose were increased significantly with dose-and time-dependence.	ros	182-185	BCL2 associated X, apoptosis regulator	Homo sapiens	150-153
25130469-7	2014	The induction by TGFbeta1 was dependent on NFkappaB activation and subsequent ROS generation.	ros	78-81	transforming growth factor beta 1	Homo sapiens	17-25
25111957-8	2014	Moreover, OA co-administration can significantly reduce the activity and expressions of CYP2E1 and ADH, which has characteristic of generation ROS mediated oxidative stress and acetaldehyde respectively.	ros	143-146	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	88-102
25277183-3	2014	Herein, we reported that 3,3"-diselenodipropionic acid (DSeA), a Selenocysteine derivative, could synergistically enhance the growth inhibitory effect of TRAIL on A375 melanoma cells though induction of ROS-dependent apoptosis with involvement of PTEN-mediated Akt inactivation and DNA damage-mediated p53 phosphorylation, which subsequently activated mitochondrial and death receptor apoptotic pathways.	ros	203-206	TNF superfamily member 10	Homo sapiens	154-159
32261761-7	2014	Internalized FAC@CurP-SeNPs triggers intracellular ROS overproduction, thus activates p53, MAPKs pathways and inhibits NFkappaB and to promote cell apoptosis.	ros	51-54	tumor protein p53	Homo sapiens	86-89
24858277-0	2014	Knockdown of estrogen receptor-alpha induces autophagy and inhibits antiestrogen-mediated unfolded protein response activation, promoting ROS-induced breast cancer cell death.	ros	138-141	estrogen receptor 1	Homo sapiens	13-36
25016361-13	2014	CONCLUSION: The present study demonstrates that Hcy is able to initiate an inflammatory response in VSMCs by stimulating CRP production, which is mediated through NMDAr-ROS-ERK1/2/p38-NF-kappaB signal pathway.	ros	169-172	C-reactive protein	Rattus norvegicus	121-124
24523033-4	2014	In cultured human umbilical vein endothelium cells, Ang II stimulation increased generation of ROS and 4-hydroxy-2-nonenal, both of which were clearly restored by administration of adiponectin.	ros	95-98	angiotensinogen	Homo sapiens	52-58
24523033-4	2014	In cultured human umbilical vein endothelium cells, Ang II stimulation increased generation of ROS and 4-hydroxy-2-nonenal, both of which were clearly restored by administration of adiponectin.	ros	95-98	adiponectin, C1Q and collagen domain containing	Homo sapiens	181-192
25263976-15	2014	The generation of ROS by hydrogen peroxide may also induce ERK1/2 activation in Jurkat cells.	ros	18-21	mitogen-activated protein kinase 3	Homo sapiens	59-65
24858277-5	2014	Interestingly, ERalpha knockdown, but not ICI, reduced nuclear factor (erythroid-derived 2)-like (NRF)-2 (UPR-induced antioxidant protein) and increased cytosolic kelch-like ECH-associated protein (KEAP)-1 (NRF2 inhibitor), consistent with the observed increase in ROS production.	ros	265-268	estrogen receptor 1	Homo sapiens	15-22
25088477-5	2014	In this study, we have shown that resveratrol (at a dose of 10 muM) can decrease CS-induced ROS and carbonyl formation in human keratinocytes.	ros	92-95	latexin	Homo sapiens	63-66
24930757-0	2014	Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.	ros	136-139	TNF superfamily member 10	Homo sapiens	90-95
24930757-0	2014	Ilimaquinone induces death receptor expression and sensitizes human colon cancer cells to TRAIL-induced apoptosis through activation of ROS-ERK/p38 MAPK-CHOP signaling pathways.	ros	136-139	mitogen-activated protein kinase 1	Homo sapiens	140-143
24930757-9	2014	Finally, the generation of ROS was required for CHOP and DR5 up-regulation by ilimaquinone.	ros	27-30	DNA damage inducible transcript 3	Homo sapiens	48-52
24930757-10	2014	These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug.	ros	132-135	TNF superfamily member 10	Homo sapiens	100-105
24930757-10	2014	These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug.	ros	132-135	mitogen-activated protein kinase 1	Homo sapiens	136-139
24937322-3	2014	This study was designed to determine whether inhibition of the angiotensin-converting enzyme (ACE) in the PVN modulates cytokines and attenuates oxidative stress (ROS) in the RVLM, and decreases the blood pressure and sympathetic activity in renovascular hypertensive rats.	ros	163-166	angiotensin I converting enzyme	Rattus norvegicus	63-92
25031298-9	2014	ACE1 was positively correlated with angiotensin I, angiotensin II, TGF-beta1, Col-IV, FN, ROS, and MDA, and negatively correlated with ACE2, SOD, and GSH (each p &lt; 0.05).	ros	90-93	angiotensin I converting enzyme	Homo sapiens	0-4
24937322-3	2014	This study was designed to determine whether inhibition of the angiotensin-converting enzyme (ACE) in the PVN modulates cytokines and attenuates oxidative stress (ROS) in the RVLM, and decreases the blood pressure and sympathetic activity in renovascular hypertensive rats.	ros	163-166	angiotensin I converting enzyme	Rattus norvegicus	94-97
25175743-11	2014	Our results show that JNK activation is an early event that precedes the increase in ROS levels leading to myofibroblastic differentiation and tumor fibrosis, suggesting that inhibition of JNK may be used a method to interrupt the development of tumor desmoplasia.	ros	85-88	mitogen-activated protein kinase 8	Homo sapiens	22-25
25175743-11	2014	Our results show that JNK activation is an early event that precedes the increase in ROS levels leading to myofibroblastic differentiation and tumor fibrosis, suggesting that inhibition of JNK may be used a method to interrupt the development of tumor desmoplasia.	ros	85-88	mitogen-activated protein kinase 8	Homo sapiens	189-192
25042803-6	2014	This is due in part to reduced levels of 6PGD products ribulose-5-phosphate and NADPH, which led to reduced RNA and lipid biosynthesis as well as elevated ROS.	ros	155-158	phosphogluconate dehydrogenase	Homo sapiens	41-45
25136835-14	2014	ROS inhibition markedly decreased nuclear factor-kB (NF-kB) phosphorylation, thioredoxin interacting/inhibiting protein (TXNIP), NLRP3 inflammasome, and mature IL-1beta in high glucose treated H9c2 cells.	ros	0-3	NLR family, pyrin domain containing 3	Rattus norvegicus	129-134
25136835-14	2014	ROS inhibition markedly decreased nuclear factor-kB (NF-kB) phosphorylation, thioredoxin interacting/inhibiting protein (TXNIP), NLRP3 inflammasome, and mature IL-1beta in high glucose treated H9c2 cells.	ros	0-3	interleukin 1 beta	Rattus norvegicus	160-168
25136835-18	2014	NF-kappaB and TXNIP mediated the ROS-induced caspase-1 and IL-1beta activation, which are the effectors of NLRP3 inflammasome.	ros	33-36	interleukin 1 beta	Rattus norvegicus	59-67
25136835-18	2014	NF-kappaB and TXNIP mediated the ROS-induced caspase-1 and IL-1beta activation, which are the effectors of NLRP3 inflammasome.	ros	33-36	NLR family, pyrin domain containing 3	Rattus norvegicus	107-112
25005497-10	2014	These results suggest that cardiac AKAP150 positively responds to hyperglycemia and enhances the efficiency of glucotoxicity signaling through a cPKC/p47(phox)/ROS pathway that induces myocardial dysfunction, cardiomyocyte apoptosis, and oxidative stress.	ros	160-163	NSFL1 cofactor	Rattus norvegicus	150-153
25127027-11	2014	Sevoflurane, but not Intralipid  produced protective ROS during reperfusion, which activated Akt.	ros	53-56	AKT serine/threonine kinase 1	Rattus norvegicus	93-96
25019986-5	2014	Besides, PDE4B deletion attenuated the LPS-induced ROS generation.	ros	51-54	phosphodiesterase 4B	Homo sapiens	9-14
24910408-6	2014	In addition, in the CCl4 induced HepG2 cells injury model and the CYP3A activity level correlated well with ROS level in several ingredients of SLE treated groups, especially in gamma-schisandrin group.	ros	108-111	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-71
24936064-8	2014	Although both IL-1beta- and TNFalpha-treated myocytes showed significant increase in reactive oxidative species (ROS), Western blot experiments revealed that only IL-1beta increased PKCepsilon membrane translocation.	ros	113-116	interleukin 1 beta	Mus musculus	14-22
24936064-8	2014	Although both IL-1beta- and TNFalpha-treated myocytes showed significant increase in reactive oxidative species (ROS), Western blot experiments revealed that only IL-1beta increased PKCepsilon membrane translocation.	ros	113-116	tumor necrosis factor	Mus musculus	28-36
24954416-5	2014	These roles for Sdh8 are critical for preventing motility defects and neurodegeneration in Drosophila as well as the excess ROS generated by free Sdh1.	ros	124-127	Sorbitol dehydrogenase 1	Drosophila melanogaster	146-150
25090630-8	2014	CD4 T cells were also associated with greater levels of ROS and increased mitochondrial content, irrespective of the activation context.	ros	56-59	CD4 molecule	Homo sapiens	0-3
25090023-5	2014	Here, we present evidence for how PCB-induced ROS may contribute to the development of a neovascular phenotype with the aim of elucidating the role of environmental toxicants in endothelial dysfunction with a specific focus on the inhibitor of differentiation protein ID3.	ros	46-49	pyruvate carboxylase	Homo sapiens	34-37
25090023-5	2014	Here, we present evidence for how PCB-induced ROS may contribute to the development of a neovascular phenotype with the aim of elucidating the role of environmental toxicants in endothelial dysfunction with a specific focus on the inhibitor of differentiation protein ID3.	ros	46-49	inhibitor of DNA binding 3, HLH protein	Homo sapiens	268-271
25090023-8	2014	Our results showed that PCB-induced ROS mediated a highly tube branched neovascular phenotype that also depended on ID3 and Pyk2; and PCB153 treatment increased the size of endothelial spheroids under conditions typically used for clonal selection of stem cell spheroids.	ros	36-39	pyruvate carboxylase	Homo sapiens	24-27
25090023-8	2014	Our results showed that PCB-induced ROS mediated a highly tube branched neovascular phenotype that also depended on ID3 and Pyk2; and PCB153 treatment increased the size of endothelial spheroids under conditions typically used for clonal selection of stem cell spheroids.	ros	36-39	inhibitor of DNA binding 3, HLH protein	Homo sapiens	116-119
24796540-6	2014	We also demonstrated that effector memory CD4(+) T cells had lower autophagic activity than naive CD4(+) T cells, which contributed to their enhanced apoptosis due to increased ROS.	ros	177-180	CD4 molecule	Homo sapiens	42-45
24412988-5	2014	An increasing number of cytosolic and mitochondrial proteins involved in mitochondrial metabolism and respiration are regulated by p53, which influences mitochondrial ROS production as well.	ros	167-170	tumor protein p53	Homo sapiens	131-134
24796540-6	2014	We also demonstrated that effector memory CD4(+) T cells had lower autophagic activity than naive CD4(+) T cells, which contributed to their enhanced apoptosis due to increased ROS.	ros	177-180	CD4 molecule	Homo sapiens	98-101
24699405-7	2014	In the old cells the PGC1A-mediated mito-biogenetic response to direct AMPK-stimulation by AICAR was undiminished, while the PGC1A-independent mito-biogenetic response to starvation was attenuated and accompanied by increased ROS-production.	ros	226-229	PPARG coactivator 1 alpha	Homo sapiens	21-26
24706090-6	2014	Several enzymatic pathways seem to be implicated in ROS overproduction, which ultimately leads to enhanced vulnerability to AF; they include myeloperoxidase, Nicotinamide adenine dinucleotide phosphate oxidase, and uncoupled nitric oxide synthase enzymes.	ros	52-55	myeloperoxidase	Homo sapiens	141-156
24905957-5	2014	VIP increased cell adhesion and ROS production, and decreased VEGF165 secretion through PI3K signalling.	ros	32-35	vasoactive intestinal peptide	Homo sapiens	0-3
24821269-8	2014	Moreover, MeHg-induced ROS over-production appeared to inhibit the activities of GS, down-regulated GLAST and GLT-1 expression in cerebral cortex.	ros	23-26	solute carrier family 1 member 2	Rattus norvegicus	110-115
24972862-1	2014	The aim of this study was to verify whether the addition of catalase (20 IU/mL) at different steps of goat ovarian tissue vitrification affects ROS levels, follicular morphology and viability, stromal cell density, apoptosis and the expression of proteins related to DNA-damage signaling (gammaH2AX) and repair (53BP1).	ros	144-147	catalase	Capra hircus	60-68
24957686-7	2014	These findings suggest that pristimerin down-regulates the expression of pro-inflammatory mediators through blocking of NF-kappaB activation by inhibiting interconnected ROS/IKK/NF-kappaB signaling pathways.	ros	170-173	nuclear factor kappa B subunit 1	Homo sapiens	178-187
24867259-0	2014	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway.	ros	84-87	BCL2 related protein A1	Homo sapiens	17-23
24867259-0	2014	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway.	ros	84-87	tumor protein p53	Homo sapiens	80-83
24867259-3	2014	However, we previously demonstrated that the nutlin-3-induced mitochondrial translocation of p53 stimulates ERK1/2 activation, an anti-apoptosis signal, via mitochondrial ROS generation.	ros	171-174	tumor protein p53	Homo sapiens	93-96
24867259-3	2014	However, we previously demonstrated that the nutlin-3-induced mitochondrial translocation of p53 stimulates ERK1/2 activation, an anti-apoptosis signal, via mitochondrial ROS generation.	ros	171-174	mitogen-activated protein kinase 3	Homo sapiens	108-114
24957686-0	2014	Pristimerin, a natural anti-tumor triterpenoid, inhibits LPS-induced TNF-alpha and IL-8 production through down-regulation of ROS-related classical NF-kappaB pathway in THP-1 cells.	ros	126-129	nuclear factor kappa B subunit 1	Homo sapiens	148-157
24972862-3	2014	The vitrification without catalase had higher ROS levels than the control.	ros	46-49	catalase	Capra hircus	26-34
24972862-4	2014	The catalase, regardless the step of addition, maintained ROS levels similar to the control.	ros	58-61	catalase	Capra hircus	4-12
24972862-7	2014	In conclusion, catalase addition to vitrification solutions prevents ROS formation in cryopreserved goat ovarian tissues.	ros	69-72	catalase	Capra hircus	15-23
25015549-3	2014	Comibination of Tanshinone I and TRAIL exerted synergistic cytotoxicity, increased cleaved PARP, sub G1 population, the number of TUNELpositive cells, activated caspase 8, 9 and ROS production in PC-3 and DU145 cells.	ros	178-181	TNF superfamily member 10	Homo sapiens	33-38
24699252-6	2014	Probing of underlying mechanisms by selective pharmacological and gene silencing experiments showed that S18886 reduced U46619- or TNF-alpha-induced TF expression inhibiting ROS production, NAD(P)H oxidase and PKC activation.	ros	174-177	tumor necrosis factor	Homo sapiens	131-140
25202950-8	2014	CONCLUSION: ROS induced by free fatty acid can regulate the activation of NALP3 inflammasome signaling pathway leading to the release of inflammatory cytokines.	ros	12-15	NLR family pyrin domain containing 3	Homo sapiens	74-79
25025898-9	2014	It also inhibited cellular catalase in K562 cancer cells with significant increase in cellular ROS and suppression of cell viability (IC50 54.5 microM).	ros	95-98	catalase	Homo sapiens	27-35
25104948-0	2014	Inhibition of mTOR Prevents ROS Production Initiated by Ethidium Bromide-Induced Mitochondrial DNA Depletion.	ros	28-31	mechanistic target of rapamycin kinase	Homo sapiens	14-18
25025898-11	2014	EGCG may have other non-specific targets in the cell, but its anticancer property is mainly defined by ROS accumulation due to catalase inhibition.	ros	103-106	catalase	Homo sapiens	127-135
24812029-0	2014	Induction of ROS-independent JNK-activation-mediated apoptosis by a novel coumarin-derivative, DMAC, in human colon cancer cells.	ros	13-16	mitogen-activated protein kinase 8	Homo sapiens	29-32
24992302-6	2014	Moreover, ROS was involved in POL-induced inhibition of Akt expression, and might therefore mediate both apoptosis and autophagy in A549 cells.	ros	10-13	AKT serine/threonine kinase 1	Homo sapiens	56-59
24992685-5	2014	RESULTS: In response to treatment with either TNF-alpha or IL-6 (0-100 ng/ml, 0-24 hrs), our studies consistently demonstrated significant dose- and time-dependent decreases in the expression of all interendothelial junction proteins examined, in parallel with dose- and time-dependent increases in ROS generation and HBMvEC permeability.	ros	299-302	tumor necrosis factor	Homo sapiens	46-55
24992685-5	2014	RESULTS: In response to treatment with either TNF-alpha or IL-6 (0-100 ng/ml, 0-24 hrs), our studies consistently demonstrated significant dose- and time-dependent decreases in the expression of all interendothelial junction proteins examined, in parallel with dose- and time-dependent increases in ROS generation and HBMvEC permeability.	ros	299-302	interleukin 6	Homo sapiens	59-63
25108328-6	2014	Under oxidative stress, EYA-1 knockdown could shorten the mean lifespan by 18.7%, which could be attributed to intracellular ROS accumulation and the decrease of superoxide dismutase-3 (sod-3) protein expression.	ros	125-128	Eyes absent homolog 1	Caenorhabditis elegans	24-29
24550188-3	2014	We previously developed mice that overexpress p22phox in vascular smooth muscle, tg(sm/p22phox), which have increased vascular ROS production.	ros	127-130	dynein cytoplasmic 1 heavy chain 1	Mus musculus	46-49
24856827-2	2014	We demonstrate for the first time, to our knowledge, that ZBTB3 is an essential factor for cancer cell growth via the regulation of the ROS detoxification pathway.	ros	136-139	zinc finger and BTB domain containing 3	Homo sapiens	58-63
24856827-4	2014	In addition, we found that suppression of ZBTB3 activates a caspase cascade, including caspase-9, -3, and PARP leading to cellular apoptosis, resulting from failed ROS detoxification.	ros	164-167	zinc finger and BTB domain containing 3	Homo sapiens	42-47
24856827-5	2014	We identified that ZBTB3 plays an important role in the gene expression of ROS detoxification enzymes.	ros	75-78	zinc finger and BTB domain containing 3	Homo sapiens	19-24
24856827-6	2014	Our results reveal that ZBTB3 may play a critical role in cancer cell growth via the ROS detoxification system.	ros	85-88	zinc finger and BTB domain containing 3	Homo sapiens	24-29
24944625-9	2014	Atorvastatin significantly increased LPS induced expression of TIPE2, downregulated the expression of NOS, COX-2, MIF and NF-kappaB and the production of PGE2, NO, IL-6 and TNF-alpha in a time and dose dependent manner, and increased HO-1 protein expression, reduced ROS production in a dose dependent manner.	ros	267-270	tumor necrosis factor	Mus musculus	173-182
24865426-3	2014	Here, we found that MAOA functions to induce epithelial-to-mesenchymal transition (EMT) and stabilize the transcription factor HIF1alpha, which mediates hypoxia through an elevation of ROS, thus enhancing growth, invasiveness, and metastasis of PCa cells.	ros	185-188	hypoxia inducible factor 1 subunit alpha	Homo sapiens	127-136
24937426-5	2014	Enhanced senescence coincided with increased ROS, elevated p16(INK4a) expression, and hypophosphorylated Rb and was inhibited by treatment with a ROS scavenger or inhibition of p38/MAPK and JNK.	ros	146-149	cyclin dependent kinase inhibitor 2A	Mus musculus	63-68
24856931-0	2014	ROS-triggered phosphorylation of complex II by Fgr kinase regulates cellular adaptation to fuel use.	ros	0-3	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	47-50
24796665-4	2014	ALA pretreatment significantly reduced apoptotic cell death of the inner and outer hair cells in cisplatin-treated organ of Corti explants and attenuated ototoxicity via marked inhibition of the increase in the expression of IL-1beta and IL-6, the phosphorylation of ERK and p38, the degradation of IkappaBalpha, the increase in intracellular levels of ROS, and the activation of caspase-3 in cisplatin-treated HEI-OC1 cells.	ros	353-356	interleukin 1 beta	Homo sapiens	225-233
24915933-0	2014	Disulfiram targeting lymphoid malignant cell lines via ROS-JNK activation as well as Nrf2 and NF-kB pathway inhibition.	ros	55-58	mitogen-activated protein kinase 8	Homo sapiens	59-62
24915933-18	2014	Moreover, ROS-related activation of JNK pathway and inhibition of NF-kappaB and Nrf2 may also contribute to the DS/Cu induced apoptosis.	ros	10-13	mitogen-activated protein kinase 8	Homo sapiens	36-39
24905606-4	2014	CLS also attenuated the increase in ROS production and MMP reduction.	ros	36-39	cardiolipin synthase 1	Rattus norvegicus	0-3
24957606-4	2014	TNF-induced ROS promote nuclear IKKgamma association with ubiquitin and its complex formation with ATM for nuclear export.	ros	12-15	tumor necrosis factor	Homo sapiens	0-3
24960204-4	2014	nfkb1(-/-) fibroblasts exhibit aggravated cell senescence because of an enhanced autocrine and paracrine feedback through NF-kappaB, COX-2 and ROS, which stabilizes DNA damage.	ros	143-146	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-5
24802406-10	2014	Mechanically, MOF overexpression increased the expression of Catalase and MnSOD, which blocked TAC-induced ROS and ROS downstream c-Raf-MEK-ERK pathway that promotes hypertrophy.	ros	107-110	catalase	Mus musculus	61-69
24802406-10	2014	Mechanically, MOF overexpression increased the expression of Catalase and MnSOD, which blocked TAC-induced ROS and ROS downstream c-Raf-MEK-ERK pathway that promotes hypertrophy.	ros	107-110	superoxide dismutase 2, mitochondrial	Mus musculus	74-79
24802406-10	2014	Mechanically, MOF overexpression increased the expression of Catalase and MnSOD, which blocked TAC-induced ROS and ROS downstream c-Raf-MEK-ERK pathway that promotes hypertrophy.	ros	115-118	catalase	Mus musculus	61-69
24802406-10	2014	Mechanically, MOF overexpression increased the expression of Catalase and MnSOD, which blocked TAC-induced ROS and ROS downstream c-Raf-MEK-ERK pathway that promotes hypertrophy.	ros	115-118	superoxide dismutase 2, mitochondrial	Mus musculus	74-79
24901709-0	2014	Disruption of interleukin-1beta autocrine signaling rescues complex I activity and improves ROS levels in immortalized epithelial cells with impaired cystic fibrosis transmembrane conductance regulator (CFTR) function.	ros	92-95	interleukin 1 beta	Homo sapiens	14-31
24901709-8	2014	Externally added IL-1beta (5 ng/ml) reduces the mCx-I activity and increases the mitochondrial (MitoSOX probe) and cellular (DCFH-DA probe) ROS levels of S9 (CFTR-corrected IB3-1 CF cells) or Caco-2/pRSctrl cells (shRNA control cells) to values comparable to those of IB3-1 or Caco-2/pRS26 cells (shRNA specific for CFTR).	ros	140-143	interleukin 1 beta	Homo sapiens	17-25
24901709-10	2014	In addition, in IB3-1 or Caco-2/pRS26 cells, IL-1beta blocking antibody, IKK inhibitor III or SB203580 reduced the mitochondrial ROS levels by ~50% and the cellular ROS levels near to basal values.	ros	129-132	interleukin 1 beta	Homo sapiens	45-53
24901709-10	2014	In addition, in IB3-1 or Caco-2/pRS26 cells, IL-1beta blocking antibody, IKK inhibitor III or SB203580 reduced the mitochondrial ROS levels by ~50% and the cellular ROS levels near to basal values.	ros	165-168	interleukin 1 beta	Homo sapiens	45-53
24901709-12	2014	The results suggest that in these cells IL-1beta, through an autocrine effect, acts as a bridge connecting the CFTR with the mCx-I activity and the ROS levels.	ros	148-151	interleukin 1 beta	Homo sapiens	40-48
24727493-0	2014	Pioglitazone reduces angiotensin II-induced COX-2 expression through inhibition of ROS production and ET-1 transcription in vascular cells from spontaneously hypertensive rats.	ros	83-86	angiotensinogen	Rattus norvegicus	21-35
24632414-10	2014	We concluded that polymerization could be a mechanism that triggers the exertion of various physiological functions of this protein and that an appropriate disulfide bond between the two cysteine residues was critical for regulating the binding affinity of Cgb, which can act as a ROS scavenger, for exogenous ligands.	ros	281-284	cytoglobin	Homo sapiens	257-260
24699798-0	2014	Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro.	ros	40-43	NFE2 like bZIP transcription factor 2	Bos taurus	52-56
24699798-9	2014	These results indicate that NEFAs activate the ROS-p38-p53/Nrf2 signaling pathway to induce apoptotic damage in bovine hepatocytes.	ros	47-50	NFE2 like bZIP transcription factor 2	Bos taurus	59-63
24727493-10	2014	In conclusion, ROS production and ET-1 are involved in ANG II-induced COX-2 expression in SHRs, explaining the greater COX-2 expression observed in this strain.	ros	15-18	angiotensinogen	Rattus norvegicus	55-61
24727493-11	2014	Furthermore, pioglitazone inhibits ANG II-induced COX-2 expression likely by interfering with NF-kappaB and activator protein-1 proinflammatory pathways and downregulating ROS production and ET-1 transcription, thus contributing to the anti-inflammatory properties of glitazones.	ros	172-175	angiotensinogen	Rattus norvegicus	35-41
24910845-0	2014	Depolarization Controls TRAIL-Sensitization and Tumor-Selective Killing of Cancer Cells: Crosstalk with ROS.	ros	104-107	TNF superfamily member 10	Homo sapiens	24-29
24590062-7	2014	V79-4 cells overexpressing AKR7A5 were able to lower cellular ROS levels following treatment with H2O2 and menadione.	ros	62-65	aflatoxin B1 aldehyde reductase member 2	Cricetulus griseus	27-33
24768635-8	2014	Moreover, when ATF3 knockdown cells were exposed to CsA, a prompt induction of CHOP was observed, which stimulated ROS production and induced cell death-related genes as compared to wild type.	ros	115-118	DNA damage inducible transcript 3	Homo sapiens	79-83
24843073-2	2014	Within seconds of the onset of contractile activity, a number of rapid cellular events occur that form part of the initial signaling processes involved in PGC-1alpha gene regulation, such as elevations in cytoplasmic calcium, AMPK and p38 activation, and elevated ROS production.	ros	264-267	PPARG coactivator 1 alpha	Homo sapiens	155-165
24513179-4	2014	Increased generation of hypoxic ROS is responsible for HIF-1alpha stabilization and GLI1 upregulation.	ros	32-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	55-65
24885580-12	2014	CONCLUSIONS: These results suggest that visfatin induces MUC8 and MUC5B expression through p38 MAPK/ROS/NF-kappaB signaling pathway in human airway epithelial cells.	ros	100-103	mitogen-activated protein kinase 14	Homo sapiens	91-94
24792722-8	2014	These results suggest that betaPix phosphorylation at Ser-340 upregulates Nox1 through Rac activation, confirming Rac as a trigger for acute Nox1-dependent ROS production.	ros	156-159	Rho guanine nucleotide exchange factor 7	Homo sapiens	27-34
24792722-8	2014	These results suggest that betaPix phosphorylation at Ser-340 upregulates Nox1 through Rac activation, confirming Rac as a trigger for acute Nox1-dependent ROS production.	ros	156-159	AKT serine/threonine kinase 1	Homo sapiens	114-117
24885580-0	2014	Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-kappaB in human airway epithelial cells.	ros	56-59	mucin 8	Homo sapiens	17-21
24885580-0	2014	Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-kappaB in human airway epithelial cells.	ros	56-59	mitogen-activated protein kinase 14	Homo sapiens	47-50
24885580-6	2014	Treatment with SB203580 (p38 MAPK inhibitor) and knockdown of p38 MAPK by siRNA significantly blocked visfatin-induced MUC8 and MUC5B expression.Visfatin significantly increased ROS formation.	ros	178-181	mitogen-activated protein kinase 14	Homo sapiens	62-65
24885580-8	2014	Treatment with NAC (ROS scavenger) and DPI (NADPH oxidase inhibitor) significantly attenuated visfatin-induced MUC8 and MUC5B expression.	ros	20-23	mucin 8	Homo sapiens	111-115
24843073-3	2014	We observed that basal levels of PGC-1alpha promoter activity were more sensitive to resting Ca(2+) levels, compared to ROS, p38 or, AMPK signaling.	ros	120-123	PPARG coactivator 1 alpha	Homo sapiens	33-43
24843073-5	2014	AMPK, ROS, and Ca(2+) appear to be necessary for the regulation of contractile activity-induced PGC-1alpha gene expression, governed partly through p38 MAPK and CaMKII activity.	ros	6-9	PPARG coactivator 1 alpha	Homo sapiens	96-106
24657139-9	2014	After NIR exposed, the MC540 was activated to produce singlet oxygen (ROS) successfully by the upconverting fluorescence emitted from UCN.	ros	70-73	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	6-9
24810758-5	2014	Functional studies revealed that GA-induced dysregulation of lipid metabolism could activate 5-lipoxygenase (5-LOX), resulting in intracellular ROS accumulation, followed by inhibition of Akt-mTOR signaling and autophagy initiation.	ros	144-147	arachidonate 5-lipoxygenase	Homo sapiens	93-107
24698731-7	2014	Additionally, the transmembrane receptor-like PTPs, RPTPmicro and RPTPalpha, as well as the cytoplasmic PTP1B, are highly expressed in ROS 17/2.8 cells.	ros	135-138	protein tyrosine phosphatase, non-receptor type 1	Rattus norvegicus	104-109
24698731-8	2014	Furthermore, we evidenced that Cx43 interacts with RPTPmicro in ROS 17/2.8 and ALN decreases their association.	ros	64-67	gap junction protein, alpha 1	Rattus norvegicus	31-35
24607510-9	2014	Rhamnetin also enhanced the expression of catalase and Mn-SOD, thereby inhibiting production of intracellular ROS.	ros	110-113	catalase	Rattus norvegicus	42-50
24810758-5	2014	Functional studies revealed that GA-induced dysregulation of lipid metabolism could activate 5-lipoxygenase (5-LOX), resulting in intracellular ROS accumulation, followed by inhibition of Akt-mTOR signaling and autophagy initiation.	ros	144-147	arachidonate 5-lipoxygenase	Homo sapiens	109-114
24681980-1	2014	In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues.	ros	141-144	beta-secretase 1	Homo sapiens	67-73
24804719-12	2014	These results suggest that piperine mediated ROS played a critical role in inducing DNA damage and activation of Chk1 leading to G1 cell cycle arrest and apoptosis.	ros	45-48	checkpoint kinase 1	Homo sapiens	113-117
24681980-1	2014	In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues.	ros	141-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	79-99
24681980-1	2014	In an effort to develop multipotent agents against beta-secretase (BACE-1) and acetylcholinesterase (AChE), able to counteract intracellular ROS formation as well, the structure of the fluorinated benzophenone 3 served as starting point for the synthesis of a small library of 3-fluoro-4-hydroxy- analogues.	ros	141-144	acetylcholinesterase (Cartwright blood group)	Homo sapiens	101-105
24068521-8	2014	ROS inhibitor NAC abrogated the inhibitory effect of Hispidulin on P13k/Akt signalling pathway and the proapoptotic effect in HepG2 cells.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	72-75
25061503-2	2014	Mirk mediates cancer cell survival by decreasing toxic ROS levels through maintaining expression of a series of antioxidant genes, possibly through its transcriptional activator functions.	ros	55-58	dual specificity tyrosine phosphorylation regulated kinase 1B	Homo sapiens	0-4
24584198-7	2014	ROS inhibition exerted little effect on PPARgamma, COX-2 and FoxO4 expression but affected PGC-1alpha expression.	ros	0-3	PPARG coactivator 1 alpha	Homo sapiens	91-101
24677687-2	2014	Reviewed are also specific interactions between mTOR/S6K1 and ROS-DNA damage signaling pathways.	ros	62-65	mechanistic target of rapamycin kinase	Homo sapiens	48-52
24677687-8	2014	While the primary target of each of these agents may be different the data obtained on several human cancer cell lines, WI-38 fibroblasts and normal lymphocytes suggest common downstream mechanism in which the decline in mTOR/S6K1 signaling and translation rate is coupled with a reduction of oxidative phosphorylation and ROS that leads to decreased oxidative DNA damage.	ros	323-326	mechanistic target of rapamycin kinase	Homo sapiens	221-225
24651121-4	2014	Phloretin disturbed the multiple intracellular signaling pathways in DCs induced by the Toll-like receptor 4 (TLR4) agonist lipopolysaccharide (LPS), including ROS, MAPKs (ERK, JNK, p38 MAPK), and NF-kappaB, and thereby reducing the production of inflammatory cytokines and chemokines.	ros	160-163	toll-like receptor 4	Mus musculus	110-114
24651121-4	2014	Phloretin disturbed the multiple intracellular signaling pathways in DCs induced by the Toll-like receptor 4 (TLR4) agonist lipopolysaccharide (LPS), including ROS, MAPKs (ERK, JNK, p38 MAPK), and NF-kappaB, and thereby reducing the production of inflammatory cytokines and chemokines.	ros	160-163	toll-like receptor 4	Mus musculus	144-147
25061503-10	2014	Addition of RAD001 increased the amount of toxic ROS induced by Mirk kinase inhibition.	ros	49-52	dual specificity tyrosine phosphorylation regulated kinase 1B	Homo sapiens	64-68
24122234-4	2014	Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level.	ros	73-76	mitogen-activated protein kinase 8	Homo sapiens	96-99
24122234-4	2014	Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level.	ros	73-76	mitogen-activated protein kinase 1	Homo sapiens	148-151
24122234-4	2014	Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level.	ros	73-76	mitogen-activated protein kinase 14	Homo sapiens	104-107
24569874-0	2014	Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation.	ros	18-21	insulin	Homo sapiens	0-7
24122234-4	2014	Studies on amsacrine-treated U937 cells revealed that amsacrine-elicited ROS generation induced JNK and p38 MAPK activation but reduced the phospho-ERK level.	ros	73-76	mitogen-activated protein kinase 1	Homo sapiens	108-112
24743151-7	2014	Consequently, fatty acid metabolism and ROS production were enhanced, leading to increased AMPK phosphorylation and Ppara and Pgc1a expression.	ros	40-43	peroxisome proliferator activated receptor alpha	Mus musculus	116-121
24415791-10	2014	These data indicate that Hvcn1 ablation deregulates neutrophil pHp, leading to alkalinization in phagosomes with residual ROS production or to the early accumulation of V-ATPase on phagosomes that fail to mount an oxidative response.	ros	122-125	hydrogen voltage-gated channel 1	Mus musculus	25-30
24502693-6	2014	Angiotensin-II also induced ROS and mitochondrial dysfunction.	ros	28-31	angiotensinogen	Rattus norvegicus	0-14
24680679-0	2014	Mitochondrial translocation of Nur77 induced by ROS contributed to cardiomyocyte apoptosis in metabolic syndrome.	ros	48-51	nuclear receptor subfamily 4 group A member 1	Homo sapiens	31-36
24717093-6	2014	The increase in ROS production then triggers caspase-3 activation resulting in the inhibition of long-term potentiation.	ros	16-19	caspase 3	Homo sapiens	45-54
25282902-8	2014	CONCLUSION: Ros A has the significant effect in resisting the cardiomyocyte H/R injury, improve cardiomyocyte energy metabolism and reduce cell apoptosis, which is related to the activation of Akt pathway.	ros	12-15	AKT serine/threonine kinase 1	Rattus norvegicus	193-196
24491546-6	2014	PEITC enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-induced-p53.	ros	153-156	TNF superfamily member 10	Homo sapiens	15-20
24491546-6	2014	PEITC enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-induced-p53.	ros	153-156	tumor protein p53	Homo sapiens	165-168
24680679-7	2014	In this report, we observed that, accompanied by the substantial decline in apoptosis inducer Nur77, MI/R induced cardiac dysfunction was manifested as cardiomyopathy and increased ROS.	ros	181-184	nuclear receptor subfamily 4 group A member 1	Homo sapiens	94-99
24608673-12	2014	Pretreatment of cardiomyocytes with Pue dose-dependently inhibited Ang II-induced increases in ROS production, NF-kappaB binding activity, protein synthesis and cell breadth.	ros	95-98	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	67-73
24583396-5	2014	After CL1-0 cells were transfected with catalase-shRNA, the corresponding ROS (H2O2) level and Cat S, Cat L, or Cat K expression (or activity) was up-regulated, accompanied by an increase in cell migration and invasion.	ros	74-77	catalase	Homo sapiens	40-48
24583396-6	2014	On the other hand, ROS (H2O2) level, cathepsin S, L, and K activities, cell migration and invasion were decreased in catalase-overexpressed CL1-5 cells.	ros	19-22	catalase	Homo sapiens	117-125
24583396-7	2014	It is suggested that catalase may regulate cathepsin activity by controlling the production of ROS (H2O2), leading to variation in migration and invasion ability of lung cancer cells.	ros	95-98	catalase	Homo sapiens	21-29
24555485-0	2014	Synergistic induction of apoptosis by methylseleninic acid and cisplatin, the role of ROS-ERK/AKT-p53 pathway.	ros	86-89	mitogen-activated protein kinase 1	Homo sapiens	90-93
24555485-0	2014	Synergistic induction of apoptosis by methylseleninic acid and cisplatin, the role of ROS-ERK/AKT-p53 pathway.	ros	86-89	tumor protein p53	Homo sapiens	98-101
24699513-8	2014	The parasite-induced cell death of infected macrophages bearing the LEW-Toxo1 alleles was found to exhibit pyroptosis-like features with ROS production, the activation of caspase-1 and IL1-beta secretion.	ros	137-140	Toxoplasma gondii resistance QTL 1	Rattus norvegicus	72-77
24437944-4	2014	In this study, NGR1 preconditioning provided neuroprotective effects via suppressing H2O2-induced the intracellular ROS accumulation, the increase in the product of lipid peroxidation (MDA), protein oxidation (protein carbonyl), and DNA fragmentation (8-OHdG), and mitochondrial membrane depolarization as well as caspase-3 activation.	ros	116-119	reticulon 4 receptor	Rattus norvegicus	15-19
24787294-2	2014	Genetic changes in the carcinoma cells, such as alterations to TP53, NOTCH1, and specific gene expression profiles, contribute to derangements in cancer and microenvironment cells such as increased ROS, overproduction of cytokines, and epithelial to mesenchymal transition (EMT).	ros	198-201	tumor protein p53	Homo sapiens	63-67
26432589-10	2014	These results clearly demonstrate that the bystander effect is p53-dependent for low LET irradiation, but it is p53-independent for high LET irradiation which may be because of p53-independent ROS generation due to mitochondrial dysfunction.	ros	193-196	tumor protein p53	Homo sapiens	112-115
26432589-10	2014	These results clearly demonstrate that the bystander effect is p53-dependent for low LET irradiation, but it is p53-independent for high LET irradiation which may be because of p53-independent ROS generation due to mitochondrial dysfunction.	ros	193-196	tumor protein p53	Homo sapiens	112-115
24787294-2	2014	Genetic changes in the carcinoma cells, such as alterations to TP53, NOTCH1, and specific gene expression profiles, contribute to derangements in cancer and microenvironment cells such as increased ROS, overproduction of cytokines, and epithelial to mesenchymal transition (EMT).	ros	198-201	notch receptor 1	Homo sapiens	69-75
24423925-12	2014	RRM2-activated ERK1/2 pathway was mediated through production of ROS.	ros	65-68	mitogen-activated protein kinase 3	Homo sapiens	15-21
24681637-11	2014	Conversely, downregulation of Keap1 decreased autophagy levels, increased Nrf2 activation, upregulated cytoprotective antioxidant gene expression, and caused accumulation of p62, suggesting a feedback loop between ROS-regulated Keap1-Nrf2 and Atg7-regulated autophagy.	ros	214-217	kelch like ECH associated protein 1	Homo sapiens	228-233
24681637-11	2014	Conversely, downregulation of Keap1 decreased autophagy levels, increased Nrf2 activation, upregulated cytoprotective antioxidant gene expression, and caused accumulation of p62, suggesting a feedback loop between ROS-regulated Keap1-Nrf2 and Atg7-regulated autophagy.	ros	214-217	NFE2 like bZIP transcription factor 2	Homo sapiens	234-238
24366007-8	2014	Notably, the levels of nutlin-3-induced ROS were correlated with the mitochondrial translocation of p53 and this induction was prevented by PFT-mu, an inhibitor of the mitochondrial translocation of p53.	ros	40-43	tumor protein p53	Homo sapiens	100-103
24366007-8	2014	Notably, the levels of nutlin-3-induced ROS were correlated with the mitochondrial translocation of p53 and this induction was prevented by PFT-mu, an inhibitor of the mitochondrial translocation of p53.	ros	40-43	tumor protein p53	Homo sapiens	199-202
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	ros	127-130	mitogen-activated protein kinase 8	Homo sapiens	101-104
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	ros	127-130	tumor protein p53	Homo sapiens	144-147
24366007-11	2014	Collectively, these results suggest that nutlin-3 induces HO-1 expression via the activation of both JNK which is dependent on ROS generated by p53 translocated to the mitochondria and p38 MAPK which appears to be stimulated by a ROS-independent mechanism, and this HO-1 induction may inhibit nutlin-3-induced apoptosis, constituting a negative feedback loop of p53-induced apoptosis.	ros	230-233	mitogen-activated protein kinase 8	Homo sapiens	101-104
24462998-3	2014	We have observed hyper diploid copies of mitochondrial transcription factor A (TFAM) gene in the LCLs along with increased mtDNA copy number, mitochondrial mass, intracellular ROS and mitochondrial membrane potential, suggesting elevated mitochondrial biogenesis in LCLs.	ros	176-179	transcription factor A, mitochondrial	Homo sapiens	41-77
24462998-3	2014	We have observed hyper diploid copies of mitochondrial transcription factor A (TFAM) gene in the LCLs along with increased mtDNA copy number, mitochondrial mass, intracellular ROS and mitochondrial membrane potential, suggesting elevated mitochondrial biogenesis in LCLs.	ros	176-179	transcription factor A, mitochondrial	Homo sapiens	79-83
24681637-11	2014	Conversely, downregulation of Keap1 decreased autophagy levels, increased Nrf2 activation, upregulated cytoprotective antioxidant gene expression, and caused accumulation of p62, suggesting a feedback loop between ROS-regulated Keap1-Nrf2 and Atg7-regulated autophagy.	ros	214-217	kelch like ECH associated protein 1	Homo sapiens	30-35
24658058-4	2014	In this study, we demonstrated that IMQ can enhance aerobic glycolysis by up-regulating HIF-1alpha expression at the transcriptional and translational levels via ROS mediated STAT3- and Akt-dependent pathways, independent of TLR7/8 signaling.	ros	162-165	hypoxia inducible factor 1 subunit alpha	Homo sapiens	88-98
24658058-4	2014	In this study, we demonstrated that IMQ can enhance aerobic glycolysis by up-regulating HIF-1alpha expression at the transcriptional and translational levels via ROS mediated STAT3- and Akt-dependent pathways, independent of TLR7/8 signaling.	ros	162-165	signal transducer and activator of transcription 3	Homo sapiens	175-180
24608713-4	2014	In addition, we found that Nef protein in endothelial cells is sufficient to cause apoptosis, ROS generation and release of monocyte attractant protein-1 (MCP-1).	ros	94-97	S100 calcium binding protein B	Homo sapiens	27-30
24608713-7	2014	Analyzing the signal transduction effects of Nef in endothelial cells, we found that Nef-induced apoptosis is mediated through ROS-dependent mechanisms, while MCP-1 production is NF-kB dependent.	ros	127-130	S100 calcium binding protein B	Homo sapiens	45-48
24608713-7	2014	Analyzing the signal transduction effects of Nef in endothelial cells, we found that Nef-induced apoptosis is mediated through ROS-dependent mechanisms, while MCP-1 production is NF-kB dependent.	ros	127-130	S100 calcium binding protein B	Homo sapiens	85-88
24594588-1	2014	Many properties of Abeta such as toxicity, aggregation and ROS formation are modulated by Cu2+.	ros	59-62	amyloid beta precursor protein	Homo sapiens	19-24
24594588-5	2014	Results show that the Abeta C-terminal residues have effect on Cu2+ binding affinity, aggregation ability and inhibitory ability of ROS formation.	ros	132-135	amyloid beta precursor protein	Homo sapiens	22-27
24594691-0	2014	Human phosphatidylethanolamine-binding protein 4 promoted the radioresistance of human rectal cancer by activating Akt in an ROS-dependent way.	ros	125-128	phosphatidylethanolamine binding protein 4	Homo sapiens	6-48
24594691-0	2014	Human phosphatidylethanolamine-binding protein 4 promoted the radioresistance of human rectal cancer by activating Akt in an ROS-dependent way.	ros	125-128	AKT serine/threonine kinase 1	Homo sapiens	115-118
24594691-6	2014	Western blot showed hPEBP4 could increase the radiation-induced Akt activation, for which reactive oxygen specimen(ROS) was required.	ros	115-118	phosphatidylethanolamine binding protein 4	Homo sapiens	20-26
24594691-6	2014	Western blot showed hPEBP4 could increase the radiation-induced Akt activation, for which reactive oxygen specimen(ROS) was required.	ros	115-118	AKT serine/threonine kinase 1	Homo sapiens	64-67
24594691-7	2014	The radioresistance effect of hPEBP4 was reversed after given LY-294002 to inhibit Akt activation or antioxidant to abolish the ROS production.	ros	128-131	phosphatidylethanolamine binding protein 4	Homo sapiens	30-36
24414072-5	2014	As a consequence of increased tissue ANG II and low estrogen, a maladaptive nitric oxide synthase (NOS) system produces ROS that contribute to female sex-specific hypertensive heart disease.	ros	120-123	nitric oxide synthase 2	Homo sapiens	76-97
24586814-6	2014	Our results shown that TCHQ was more toxic than PCP and that a high dose of TCHQ led to necrotic cell death of the splenocytes through induction of massive and sudden ROS and prolonged ROS-triggered ERK activation.	ros	185-188	mitogen-activated protein kinase 1	Homo sapiens	199-202
24586814-7	2014	Inhibition of ROS production by N-acetyl-cysteine (NAC) partially restored the mitochondrial membrane potential, inhibited ERK activity, elevated caspase-3 activity and PARP cleavage, and, eventually, switched the TCHQ-induced necrosis to apoptosis.	ros	14-17	mitogen-activated protein kinase 1	Homo sapiens	123-126
24586814-7	2014	Inhibition of ROS production by N-acetyl-cysteine (NAC) partially restored the mitochondrial membrane potential, inhibited ERK activity, elevated caspase-3 activity and PARP cleavage, and, eventually, switched the TCHQ-induced necrosis to apoptosis.	ros	14-17	caspase 3	Homo sapiens	146-155
24586814-7	2014	Inhibition of ROS production by N-acetyl-cysteine (NAC) partially restored the mitochondrial membrane potential, inhibited ERK activity, elevated caspase-3 activity and PARP cleavage, and, eventually, switched the TCHQ-induced necrosis to apoptosis.	ros	14-17	poly(ADP-ribose) polymerase 1	Homo sapiens	169-173
24423925-14	2014	CONCLUSION: HPVE7 induces upregulation of RRM2, which then promotes cervical carcinogenesis via ROS-ERK1/2-HIF-1alpha-VEGF-induced angiogenesis.	ros	96-99	mitogen-activated protein kinase 3	Homo sapiens	100-106
24423925-14	2014	CONCLUSION: HPVE7 induces upregulation of RRM2, which then promotes cervical carcinogenesis via ROS-ERK1/2-HIF-1alpha-VEGF-induced angiogenesis.	ros	96-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
24423925-14	2014	CONCLUSION: HPVE7 induces upregulation of RRM2, which then promotes cervical carcinogenesis via ROS-ERK1/2-HIF-1alpha-VEGF-induced angiogenesis.	ros	96-99	vascular endothelial growth factor A	Homo sapiens	118-122
24639901-12	2014	The protein and gene expressions of p22(phox) and p47(phox) were markedly reduced after pioglitazone treatment, so did the ROS generation.	ros	123-126	cytochrome b-245 alpha chain	Rattus norvegicus	40-44
24269727-0	2014	ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells.	ros	0-3	tumor protein p53	Homo sapiens	38-41
24269727-9	2014	Therefore OBPHA, having a structurally relevant pharmacophore provides important insight into the development of new ROS and RNS generating chemicals inducing p53 dependent apoptosis.	ros	117-120	tumor protein p53	Homo sapiens	159-162
24639901-12	2014	The protein and gene expressions of p22(phox) and p47(phox) were markedly reduced after pioglitazone treatment, so did the ROS generation.	ros	123-126	NSFL1 cofactor	Rattus norvegicus	50-53
24639901-12	2014	The protein and gene expressions of p22(phox) and p47(phox) were markedly reduced after pioglitazone treatment, so did the ROS generation.	ros	123-126	cytochrome b-245 alpha chain	Rattus norvegicus	54-58
23892647-7	2014	The activation of eIF2alpha, ATF4 and ATF6 and expression of GRP78 and CHOP are repressed by both LA and tiron, indicating arsenic-induced UPR is mediated through ROS-dependent and ROS-independent pathways.	ros	163-166	heat shock protein 5	Mus musculus	61-66
24363111-2	2014	Inflammation is characterized by the infiltration of cells such as neutrophilic granulocytes and (a) the release of phospholipases [particularly phospholipase A2 (PLA2)] and (b) the generation of reactive oxygen as well as nitrogen species (ROS and RNS).	ros	241-244	phospholipase A2 group IB	Homo sapiens	163-167
24291453-6	2014	Treatment of HepG2 cells with CSPC caused a loss of mitochondrial membrane potential and stimulated reactive oxidative species (ROS) generation.	ros	128-131	granzyme H	Homo sapiens	30-34
24291453-7	2014	These results suggested CSPC could trigger apoptosis and necrotic cell death in HepG2 cell, which might be associated with ROS generation through the mitochondria-dependent signaling way.	ros	123-126	granzyme H	Homo sapiens	24-28
24296130-8	2014	These results suggest that the molecular mechanism mediating ROS-dependent COX-2 up-regulation and PGE2 production by genipin involves activation of Akt, MAPKs and AP-1/NF-kappaB.	ros	61-64	thymoma viral proto-oncogene 1	Mus musculus	149-152
24296130-8	2014	These results suggest that the molecular mechanism mediating ROS-dependent COX-2 up-regulation and PGE2 production by genipin involves activation of Akt, MAPKs and AP-1/NF-kappaB.	ros	61-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	169-178
25015733-13	2014	ROS scavenger dissociated TXNIP from NLRP3 and inhibited the activation of NLRP3 inflammasome in the CMECs.	ros	0-3	thioredoxin interacting protein	Mus musculus	26-31
24704995-9	2014	Intensity of TGF-beta1 expression was weaker in ChRCCs than the one observed in ROs (P&amp;lt;0.05).	ros	80-83	transforming growth factor beta 1	Homo sapiens	13-22
24704995-13	2014	Our results showed different types of TGF-beta1 expression in ChRCCs and ROs: ChRCCs had predominantly membranous type of reaction, and ROs predominantly cytoplasmic.	ros	73-76	transforming growth factor beta 1	Homo sapiens	38-47
24704995-13	2014	Our results showed different types of TGF-beta1 expression in ChRCCs and ROs: ChRCCs had predominantly membranous type of reaction, and ROs predominantly cytoplasmic.	ros	136-139	transforming growth factor beta 1	Homo sapiens	38-47
24470519-4	2014	In accordance, the expression pattern of the genes involved in ROS metabolism changed significantly in HSCs from ApoE(-/-) mice.	ros	63-66	apolipoprotein E	Mus musculus	113-117
24161787-7	2014	Moreover, the andrographolide-induced Hsp90 cleavage, Src degradation, inhibition of transformation, and induction of apoptosis were abolished by a ROS inhibitor, N-acetyl-cysteine.	ros	148-151	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-57
23318445-6	2014	This is accompanied by inactivation of enzymes that are essential for the energy production (F1F0ATPase and cytochrome C oxidase) and detoxification of ROS (superoxide dismutase, SOD1).	ros	152-155	superoxide dismutase 1	Homo sapiens	179-183
24259511-8	2014	Knockdown of either Smad2 or Smad3 prevented the increase of Nox4 expression, ROS generation, loss of mitochondrial membrane potential, and caspase-3 activation by TGF-beta1.	ros	78-81	SMAD family member 2	Mus musculus	20-25
24259511-9	2014	These results suggest that TGF-beta1-induced mitochondrial Nox4 upregulation via the TGF-beta receptor-Smad2/3 pathway is responsible for ROS production, mitochondrial dysfunction, and apoptosis, which may at least in part contribute to the development and progression of proteinuric glomerular diseases such as diabetic nephropathy.	ros	138-141	SMAD family member 2	Mus musculus	103-108
24466113-0	2014	Clostridium perfringens phospholipase C induced ROS production and cytotoxicity require PKC, MEK1 and NFkappaB activation.	ros	48-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	102-110
24466113-3	2014	In the present work, the role of PKC, ERK 1/2 and NFkappaB signalling pathways in ROS generation induced by CpPLC and their contribution to CpPLC-induced cytotoxicity was evaluated.	ros	82-85	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-58
24466113-4	2014	The results demonstrate that CpPLC induces ROS production through PKC, MEK/ERK and NFkappaB pathways, the latter being activated by the MEK/ERK signalling cascade.	ros	43-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	83-91
24465942-5	2014	Simultaneously, ROS/RNS activate c-Jun NH2-terminal kinase (JNK) and p38 kinase.	ros	16-19	mitogen-activated protein kinase 8	Homo sapiens	33-58
24465942-5	2014	Simultaneously, ROS/RNS activate c-Jun NH2-terminal kinase (JNK) and p38 kinase.	ros	16-19	mitogen-activated protein kinase 8	Homo sapiens	60-63
24465942-5	2014	Simultaneously, ROS/RNS activate c-Jun NH2-terminal kinase (JNK) and p38 kinase.	ros	16-19	mitogen-activated protein kinase 14	Homo sapiens	69-72
24465942-7	2014	Pretreatment of the cells with antioxidants, JNK and p38 inhibitors, or JNK and p38 siRNA abrogates the depolarization of mitochondrial membrane potential and impairs the air plasma-induced apoptotic cell death, suggesting that the ROS/RNS generated by plasma trigger signaling pathways involving JNK and p38 and promote mitochondrial perturbation, leading to apoptosis.	ros	232-235	mitogen-activated protein kinase 8	Homo sapiens	72-75
24465942-7	2014	Pretreatment of the cells with antioxidants, JNK and p38 inhibitors, or JNK and p38 siRNA abrogates the depolarization of mitochondrial membrane potential and impairs the air plasma-induced apoptotic cell death, suggesting that the ROS/RNS generated by plasma trigger signaling pathways involving JNK and p38 and promote mitochondrial perturbation, leading to apoptosis.	ros	232-235	mitogen-activated protein kinase 14	Homo sapiens	80-83
24465942-7	2014	Pretreatment of the cells with antioxidants, JNK and p38 inhibitors, or JNK and p38 siRNA abrogates the depolarization of mitochondrial membrane potential and impairs the air plasma-induced apoptotic cell death, suggesting that the ROS/RNS generated by plasma trigger signaling pathways involving JNK and p38 and promote mitochondrial perturbation, leading to apoptosis.	ros	232-235	mitogen-activated protein kinase 8	Homo sapiens	72-75
24465942-7	2014	Pretreatment of the cells with antioxidants, JNK and p38 inhibitors, or JNK and p38 siRNA abrogates the depolarization of mitochondrial membrane potential and impairs the air plasma-induced apoptotic cell death, suggesting that the ROS/RNS generated by plasma trigger signaling pathways involving JNK and p38 and promote mitochondrial perturbation, leading to apoptosis.	ros	232-235	mitogen-activated protein kinase 14	Homo sapiens	80-83
24664744-3	2014	Loss- of- expression of the retina specific cell surface protein, retinoschsin (Rs1-KO), led to a dramatic 3-10 fold increase, depending on age, in the luminance threshold for transducin translocation from ROS into IS compared with wild-type control.	ros	206-209	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	80-83
24664744-4	2014	In contrast, arrestin translocated from IS into ROS at the same light intensity both in WT and Rs1-KO mice.	ros	48-51	retinoschisis (X-linked, juvenile) 1 (human)	Mus musculus	95-98
24901006-6	2014	Besides, NDGA increased ROS production, which might be related to the increase on p24 level observed in NDGA treated U1.	ros	24-27	transmembrane p24 trafficking protein 2	Homo sapiens	82-85
24060752-2	2014	CYP2E1-generated ROS contributes to the ethanol-induced oxidant stress and inhibition of CYP2E1 activity decreases ethanol-induced fatty liver.	ros	17-20	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
25177688-3	2014	RESULTS: PBE and catechin decreased basal ROS generation in slices and blunted the prooxidant effects of neurotoxicants on membrane lipid peroxidation and nonprotein thiol contents.	ros	42-45	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	9-12
25177688-5	2014	Both PBE and catechin also mitigated SNP- or CaCl2-dependent mitochondrial ROS generation.	ros	75-78	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	5-8
25093162-9	2014	TNF-alpha-induced necroptosis of HT-22 cells is largely independent of both ROS accumulation and calcium influx although these events have been shown to be critical for necroptosis in certain cell lines.	ros	76-79	tumor necrosis factor	Mus musculus	0-9
25093162-10	2014	Taken together, these data not only provide the first in vivo evidence for a role of RIP3 in TNF-alpha-induced toxicity of hippocampal neurons, but also demonstrate that TNF-alpha promotes CYLD-RIP1-RIP3-MLKL-mediated necroptosis of hippocampal neurons largely bypassing ROS accumulation and calcium influx.	ros	271-274	tumor necrosis factor	Mus musculus	93-102
25093162-10	2014	Taken together, these data not only provide the first in vivo evidence for a role of RIP3 in TNF-alpha-induced toxicity of hippocampal neurons, but also demonstrate that TNF-alpha promotes CYLD-RIP1-RIP3-MLKL-mediated necroptosis of hippocampal neurons largely bypassing ROS accumulation and calcium influx.	ros	271-274	tumor necrosis factor	Mus musculus	170-179
25093162-10	2014	Taken together, these data not only provide the first in vivo evidence for a role of RIP3 in TNF-alpha-induced toxicity of hippocampal neurons, but also demonstrate that TNF-alpha promotes CYLD-RIP1-RIP3-MLKL-mediated necroptosis of hippocampal neurons largely bypassing ROS accumulation and calcium influx.	ros	271-274	receptor (TNFRSF)-interacting serine-threonine kinase 1	Mus musculus	194-198
25101711-6	2014	Decreased levels of Nrf2 and augmentation of oxidative stress in AD suggest that the ROS-dependent mechanism of activating the Nrf2/ARE pathway has become unresponsive.	ros	85-88	NFE2 like bZIP transcription factor 2	Homo sapiens	20-24
25401388-8	2014	Silencing of Cx43 expression attenuates the increase of ROS production and the subsequent up-regulation of the Bax/Bcl-2 ratio, which partially inhibited the podocytes apoptosis.	ros	56-59	gap junction protein, alpha 1	Rattus norvegicus	13-17
25101711-6	2014	Decreased levels of Nrf2 and augmentation of oxidative stress in AD suggest that the ROS-dependent mechanism of activating the Nrf2/ARE pathway has become unresponsive.	ros	85-88	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
25101711-7	2014	A combination of agents that can either activate the Nrf2-ARE pathway by ROS-independent mechanisms, or by acting directly as antioxidant chemicals, may be necessary to reduce oxidative stress in AD.	ros	73-76	NFE2 like bZIP transcription factor 2	Homo sapiens	53-57
24043260-7	2014	Rap1GAP-induced ROS generation was inhibited by active Rap1a, but not Rap1b, and activation of Rap1a by 8CPT in Rap1b(-/-) mice reduced laser-induced CNV, in correlation with decreased ROS generation in RPE/choroid.	ros	185-188	RAS related protein 1b	Mus musculus	112-117
24616552-5	2014	Here, we reported that TNF-alpha-induced cPLA2 expression was mediated through TNFR1/PKCalpha-dependent signaling pathways, including NADPH oxidase (NOX) activation/ROS production and NF-kappaB activation.	ros	165-168	tumor necrosis factor	Homo sapiens	23-32
25095669-6	2014	Probably an increase of the level of cytochrome P450 2E1 leads to induction of expression of enzymes with cytoprotective properties, such as heme oxygenase-1, by ROS-dependent activation of certain signaling pathways.	ros	162-165	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	37-56
24616552-5	2014	Here, we reported that TNF-alpha-induced cPLA2 expression was mediated through TNFR1/PKCalpha-dependent signaling pathways, including NADPH oxidase (NOX) activation/ROS production and NF-kappaB activation.	ros	165-168	protein kinase C alpha	Homo sapiens	85-93
24616552-6	2014	CO-RM2 significantly suppressed TNF-alpha-induced cPLA2 expression by inhibiting the ROS generation and the phosphorylation of NF-kappaB p65 and IKK alpha/beta, but not the phosphorylation of p38 MAPK and JNK1/2.	ros	85-88	tumor necrosis factor	Homo sapiens	32-41
25045415-2	2014	SIRT4 modulates the metabolism of free fatty acids reducing their high circulating levels but, unfortunately, increasing ROS production.	ros	121-124	sirtuin 4	Homo sapiens	0-5
25298619-10	2014	In contrast, miR-146a mimic transfection attenuated HG/thrombin-induced upregulation of Nox4 expression, ROS generation, and inflammatory phenotypes.	ros	105-108	coagulation factor II, thrombin	Homo sapiens	55-63
23933736-6	2013	Additionally, the decrease in JNK1 phosphorylation observed with Myc knockdown is associated with a reduction in ROS production.	ros	113-116	mitogen-activated protein kinase 8	Homo sapiens	30-34
25028602-5	2014	Our results clearly show that NAC administration depresses the expression of manganese superoxide dismutase (MnSOD) and TP53-induced glycolysis and apoptosis regulator (TIGAR), both of which play a predominant antioxidant role in mitochondria by reducing ROS level.	ros	255-258	superoxide dismutase 2, mitochondrial	Mus musculus	77-107
25482750-7	2014	Here we provide additional evidence linking ABI4 with ABA- and auxin-controlled inhibition of germination and suggest a hypothetical model for the role of APX6 in the regulation of the crosstalk between these hormones and ROS.	ros	222-225	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	44-48
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	26-29	mitogen-activated protein kinase 14	Homo sapiens	41-44
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	26-29	mitogen-activated protein kinase 8	Homo sapiens	79-82
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	26-29	mitogen-activated protein kinase 14	Homo sapiens	223-226
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	26-29	mitogen-activated protein kinase 8	Homo sapiens	227-230
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	194-197	mitogen-activated protein kinase 14	Homo sapiens	41-44
24414309-4	2014	The findings suggest that 1 and 2 could enhance the expression of SOD and decrease that of NADPH oxidase, which resulted in the elimination of ROS.	ros	143-146	superoxide dismutase 1	Homo sapiens	66-69
25462070-5	2014	Gene therapy through lentivirus-carried endothelium-specific delivery to the vascular wall in high-fat diet (HFT) mice shows that the SOD2 expression in endothelial cells normalizes E2 deficiency-induced ROS generation with ameliorated mitochondrial dysfunction and vascular damage, while SOD2 knockdown worsens the problem despite the presence of E2, indicating that E2-induced SOD2 expression plays an important vasculoprotective role.	ros	204-207	superoxide dismutase 2, mitochondrial	Mus musculus	134-138
24391542-8	2013	In addition, our data and that from other groups suggest that signaling through the NMDA receptor/PKC/NOX2 cascade generates ROS that activate the PI3/mTOR pathway and finally leads to the generation of new oligodendrocytes.	ros	125-128	mechanistic target of rapamycin kinase	Homo sapiens	151-155
24367705-6	2013	Phagocytosis assays determined that Bb-elicited IL-10 levels can diminish Bb uptake and trafficking by MOs, suppresses ROS production, but does not affect NO production; Bb-elicited IL-10 had little effect on phagocytosis, ROS, and NO production by DCs.	ros	119-122	interleukin 10	Mus musculus	48-53
24367705-6	2013	Phagocytosis assays determined that Bb-elicited IL-10 levels can diminish Bb uptake and trafficking by MOs, suppresses ROS production, but does not affect NO production; Bb-elicited IL-10 had little effect on phagocytosis, ROS, and NO production by DCs.	ros	223-226	interleukin 10	Mus musculus	48-53
23973637-0	2013	Comparative analysis of ER stress response into HIV protease inhibitors: lopinavir but not darunavir induces potent ER stress response via ROS/JNK pathway.	ros	139-142	mitogen-activated protein kinase 8	Homo sapiens	143-146
24268699-6	2013	Moreover, we found that ROS-induced autophagy acts as a negative feedback regulator of JNK activity by dissociating Atg9/mAtg9 from dTRAF2/TRAF6 in Drosophila and mammalian cells, respectively.	ros	24-27	Autophagy-related 9	Drosophila melanogaster	116-120
24018486-6	2013	Unraveling the mechanism of action, our RT-PCR and western blot analysis suggest that enhanced expression of HO-1 underlies the protective effect of EG on ROS level in mice lung tissue.	ros	155-158	heme oxygenase 1	Mus musculus	109-113
24121479-0	2013	A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signaling.	ros	93-96	mitogen-activated protein kinase 14	Homo sapiens	112-115
24184774-7	2013	Elevation of intracellular ROS level and down-regulation of two ROS detoxifying enzymes, ascorbate peroxidase (APx) and trypanothione reductase (TR) suggested essential role of ROS machinery during spinigerin mediated cell death.	ros	64-67	trypanothione reductase	Leishmania donovani	145-147
24184774-7	2013	Elevation of intracellular ROS level and down-regulation of two ROS detoxifying enzymes, ascorbate peroxidase (APx) and trypanothione reductase (TR) suggested essential role of ROS machinery during spinigerin mediated cell death.	ros	64-67	trypanothione reductase	Leishmania donovani	145-147
24184774-11	2013	Computational analysis suggests spiningerin interacts with trypanothione reductase and thus probably interferes its function to detoxify the toxic ROS level.	ros	147-150	trypanothione reductase	Leishmania donovani	59-82
24344990-6	2013	RESULTS: MVE-exposed Apo E(-/-) mice showed increased BBB permeability, elevated ROS and increased MMP-2 and -9 activity, compared to FA controls.	ros	81-84	apolipoprotein E	Mus musculus	21-26
24218080-0	2013	Ribosylation of bovine serum albumin induces ROS accumulation and cell death in cancer line (MCF-7).	ros	45-48	albumin	Homo sapiens	23-36
23994772-5	2013	Furthermore, in a mouse model, Ang II infusion for 3 weeks significantly increased cardiac hypertrophy, apoptosis, inflammation, and ROS generation but decreased cardiac function compared with control mice, and similar effects were also observed in mice in the memory condition.	ros	133-136	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	31-37
23973637-6	2013	A comparison among the most clinically used PIs, ritonavir (RTV), LPV, and DRV, revealed that LPV potently and RTV moderately but not DRV induced ER stress via ROS-dependent JNK activation rather than proteasome inhibition.	ros	160-163	mitogen-activated protein kinase 8	Homo sapiens	174-177
23908488-8	2013	Similarly, polymerase I transcript release factor (PTRF) deficiency resulted in decreased iNOS and NO/ROS production in macrophages in vitro.	ros	102-105	caveolae associated 1	Mus musculus	11-49
24001789-0	2013	ZnO nanoparticles induce TNF-alpha expression via ROS-ERK-Egr-1 pathway in human keratinocytes.	ros	50-53	tumor necrosis factor	Homo sapiens	25-34
24001789-0	2013	ZnO nanoparticles induce TNF-alpha expression via ROS-ERK-Egr-1 pathway in human keratinocytes.	ros	50-53	mitogen-activated protein kinase 1	Homo sapiens	54-57
24001789-12	2013	CONCLUSIONS: The present study demonstrated that ZnO-NPs might induce inflammatory response via ROS-ERK-Egr-1 pathway in human keratinocytes.	ros	96-99	mitogen-activated protein kinase 1	Homo sapiens	100-103
23908488-8	2013	Similarly, polymerase I transcript release factor (PTRF) deficiency resulted in decreased iNOS and NO/ROS production in macrophages in vitro.	ros	102-105	caveolae associated 1	Mus musculus	51-55
23994065-6	2013	In addition, over-expression of Nrf2 significantly decreased ROS generation and diminished apoptosis in ethanol-exposed NCCs.	ros	61-64	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
23964117-7	2013	We noticed that all of these signaling molecules, except p38 MAPK and ROS, were indispensable for the induction of MCP-1 and MIP-1alpha.	ros	70-73	mast cell protease 1	Mus musculus	115-120
24184570-0	2013	GS-2, a pyrazolo[1,5-a]indole derivative with inhibitory activity of topoisomerases, exerts its potent cytotoxic activity by ROS generation.	ros	125-128	patatin like phospholipase domain containing 4	Homo sapiens	0-4
24070585-7	2013	LPS increased production of TNF-alpha, ROS, and H2O2 and expression of gp91(phox), an active subunit of NADPH oxidase, in a dose- and time-dependent manner, which was significantly reduced by TTX or TTX+cariporide.	ros	39-42	toll-like receptor 4	Mus musculus	0-3
24236104-9	2013	Furthermore, CBS also regulates bioenergetics of ovarian cancer cells by regulating mitochondrial ROS production, oxygen consumption and ATP generation.	ros	98-101	cystathionine beta-synthase	Homo sapiens	13-16
24140062-0	2013	SIRT5 desuccinylates and activates SOD1 to eliminate ROS.	ros	53-56	superoxide dismutase 1	Homo sapiens	35-39
24140062-5	2013	SOD1-mediated ROS reduction is increased when SIRT5 is co-expressed.	ros	14-17	superoxide dismutase 1	Homo sapiens	0-4
24264044-6	2013	In the kidneys, both NADPH oxidase and mitochondrial metabolism are important sources of TGF-beta1-induced cellular ROS.	ros	116-119	transforming growth factor beta 1	Homo sapiens	89-98
23521574-0	2013	Is myeloperoxidase a key component in the ROS-induced vascular damage related to nephropathy in type 2 diabetes?	ros	42-45	myeloperoxidase	Homo sapiens	3-18
24077485-3	2013	ROS formation and changes in mitochondrial transmembrane potential may have influenced caspase-3 activation, a crucial enzyme in the apoptotic process.	ros	0-3	caspase 3	Homo sapiens	87-96
24184570-3	2013	In this study, we investigated whether GS-2, one of the derivatives, altered the levels of ROS in breast cancer MDA-231 cells and whether these ROS contributed to the observed antitumoral activity.	ros	91-94	patatin like phospholipase domain containing 4	Homo sapiens	39-43
24184570-4	2013	Our data revealed that GS-2 caused a time- and dose-dependent elevation of intracellular ROS level in MDA-231 cells.	ros	89-92	patatin like phospholipase domain containing 4	Homo sapiens	23-27
24184570-7	2013	The addition of N-acetyl cysteine (NAC, a well-known antioxidant) could effectively attenuate the GS-2-induced ROS enhancement and subsequent apoptosis.	ros	111-114	patatin like phospholipase domain containing 4	Homo sapiens	98-102
24184570-8	2013	NAC attenuated the induced inhibition on expression of topos, indicating that topos might be the target of GS-2-induced ROS.	ros	120-123	patatin like phospholipase domain containing 4	Homo sapiens	107-111
24036448-4	2013	The overexpression of the carboxy-terminal domain of GRK2 (betaARK-ct), known to displace GRK2 from plasma membranes, induces earlier localization of GRK2 to mitochondria in response to LPS leading to increased mt-DNA transcription and reduced ROS production and cytokine expression.	ros	244-247	G protein-coupled receptor kinase 2	Homo sapiens	53-57
24036448-4	2013	The overexpression of the carboxy-terminal domain of GRK2 (betaARK-ct), known to displace GRK2 from plasma membranes, induces earlier localization of GRK2 to mitochondria in response to LPS leading to increased mt-DNA transcription and reduced ROS production and cytokine expression.	ros	244-247	G protein-coupled receptor kinase 2	Homo sapiens	90-94
24036448-4	2013	The overexpression of the carboxy-terminal domain of GRK2 (betaARK-ct), known to displace GRK2 from plasma membranes, induces earlier localization of GRK2 to mitochondria in response to LPS leading to increased mt-DNA transcription and reduced ROS production and cytokine expression.	ros	244-247	G protein-coupled receptor kinase 2	Homo sapiens	90-94
23994248-10	2013	Because mitochondria are a target of both [Cu(isaepy)] and galectin-3, we propose that the presence of galectin-3 in this organelle favors increased ROS production, thereby inducing oxidative cellular damage and apoptotic death.	ros	149-152	lectin, galactose binding, soluble 3	Mus musculus	103-113
24056253-11	2013	Finally, the upsurge of ROS production was found in high glucose treated C6 cells and chelation of ROS could partially restore the GRP78 expression.	ros	24-27	heat shock protein 5	Mus musculus	131-136
24056253-11	2013	Finally, the upsurge of ROS production was found in high glucose treated C6 cells and chelation of ROS could partially restore the GRP78 expression.	ros	99-102	heat shock protein 5	Mus musculus	131-136
23529952-5	2013	Results indicate that PEG2000-DPSE-QUE-NPS showed dose-dependent cytotoxicity to C6 glioma cells and enhanced ROS accumulation induced upregulation of p53 protein, which was accompanied with an increase in cytochrome c and caspase-3 protein levels.	ros	110-113	tumor protein p53	Homo sapiens	151-154
23529952-5	2013	Results indicate that PEG2000-DPSE-QUE-NPS showed dose-dependent cytotoxicity to C6 glioma cells and enhanced ROS accumulation induced upregulation of p53 protein, which was accompanied with an increase in cytochrome c and caspase-3 protein levels.	ros	110-113	caspase 3	Homo sapiens	223-232
23769964-11	2013	In conclusion, the study highlights ROS mediated DNA damage, lysosomal and mitochondrial destabilization via upregulation of Bax and activation of caspase-3 which further leads to apoptosis.	ros	36-39	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
23769964-11	2013	In conclusion, the study highlights ROS mediated DNA damage, lysosomal and mitochondrial destabilization via upregulation of Bax and activation of caspase-3 which further leads to apoptosis.	ros	36-39	caspase 3	Homo sapiens	147-156
24116164-7	2013	In contrast, UII treatment increased ROS production and p47-phox and p67-phox translocation, and decreased the phosphorylated AKT, ERK1/2 and p38MAPK; Apocynin abrogated this effect.	ros	37-40	urotensin 2	Mus musculus	13-16
23876460-8	2013	Collectively, these results suggest that Cd increases intracellular Ca2+ or ROS, which induces gamma-secretase-dependent N-cad/CTF2 production via the activation of the ERK signaling pathway in C6 glial cells.	ros	76-79	mitogen-activated protein kinase 1	Homo sapiens	169-172
24136222-0	2013	Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.	ros	50-53	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	103-106
23774252-11	2013	We demonstrated that NADPH oxidase-derived ROS generation is involved in TNF-alpha-induced PYK2 activation in these cells.	ros	43-46	tumor necrosis factor	Rattus norvegicus	73-82
23774252-11	2013	We demonstrated that NADPH oxidase-derived ROS generation is involved in TNF-alpha-induced PYK2 activation in these cells.	ros	43-46	protein tyrosine kinase 2 beta	Rattus norvegicus	91-95
24113182-12	2013	Thus, TAK1 deficiency in metastatic cancer cells increases integrin:Rac-induced ROS, which negatively regulated Rho by LMW-PTP to accelerate EMT.	ros	80-83	AKT serine/threonine kinase 1	Homo sapiens	68-71
23933517-2	2013	Activated RAF, AKT, Bcl-2 and antioxidants protected equally well against ROS accumulation and subsequent death.	ros	74-77	zinc fingers and homeoboxes 2	Mus musculus	10-13
23933517-2	2013	Activated RAF, AKT, Bcl-2 and antioxidants protected equally well against ROS accumulation and subsequent death.	ros	74-77	B cell leukemia/lymphoma 2	Mus musculus	20-25
23933517-10	2013	Together these data suggest Bcl-2 family proteins as convergence point for RAF and ROS in life and death decisions.	ros	83-86	B cell leukemia/lymphoma 2	Mus musculus	28-33
23774252-0	2013	NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-alpha-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells.	ros	14-17	protein tyrosine kinase 2 beta	Rattus norvegicus	28-32
23774252-0	2013	NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-alpha-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells.	ros	14-17	tumor necrosis factor	Rattus norvegicus	59-68
23774252-6	2013	Moreover, TNF-alpha markedly induced NADPH oxidase-derived ROS generation in these cells.	ros	59-62	tumor necrosis factor	Rattus norvegicus	10-19
24032351-5	2013	Our observations in tissue bath studies were confirmed by Western blotting; 2,3-cis-procyanidins induced phosphorylation of eNOS and Akt in a ROS-dependent manner.	ros	142-145	AKT serine/threonine kinase 1	Homo sapiens	133-136
24116164-8	2013	In conclusion, UII increased ROS production by NADPH oxidase, leading to the inhibition of signaling pathways involving glucose transport, such as AKT/PKC/ERK.	ros	29-32	urotensin 2	Mus musculus	15-18
23713977-10	2013	Our results demonstrate that Hb-induced NF-kappaB and HIF are regulated by two mechanisms, either MyD88 activation or Hb transition state-induced ROS formation, that influence HMEC-1 permeability.	ros	146-149	nuclear factor kappa B subunit 1	Homo sapiens	40-49
23707663-7	2013	Further, AGE formation was decreased to the greatest extent with the inhibitor for CYP2E1 suggesting that high glucose inducible CYP2E1 and the consequent ROS aid AGE formation.	ros	155-158	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	83-89
23643711-2	2013	However, the mechanism by which the ROS induce insulin resistance in skeletal muscle cells is not completely understood.	ros	36-39	insulin	Homo sapiens	47-54
23707663-7	2013	Further, AGE formation was decreased to the greatest extent with the inhibitor for CYP2E1 suggesting that high glucose inducible CYP2E1 and the consequent ROS aid AGE formation.	ros	155-158	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	129-135
23643711-4	2013	Our hypothesis is that the low mitochondrial oxygen consumption leads to elevated ROS production by a mechanism associated with reduced PGC1alpha transcription and low content of phosphorylated CREB.	ros	82-85	PPARG coactivator 1 alpha	Homo sapiens	136-145
23842993-0	2013	Salvianolic acid B induces apoptosis in human glioma U87 cells through p38-mediated ROS generation.	ros	84-87	mitogen-activated protein kinase 14	Homo sapiens	71-74
23842993-6	2013	Moreover, blocking p38 activation by specific inhibitor SB203580 or p38 specific siRNA partly reversed the anti-proliferative and pro-apoptotic effects, and ROS production induced by SalB treatment.	ros	157-160	mitogen-activated protein kinase 14	Homo sapiens	19-22
23842993-6	2013	Moreover, blocking p38 activation by specific inhibitor SB203580 or p38 specific siRNA partly reversed the anti-proliferative and pro-apoptotic effects, and ROS production induced by SalB treatment.	ros	157-160	mitogen-activated protein kinase 14	Homo sapiens	68-71
23842993-8	2013	All of these findings extended the anti-cancer effect of SalB in human glioma cell lines, and suggested that these inhibitory effects of SalB on U87 glioma cell growth might be associated with p38 activation mediated ROS generation.	ros	217-220	mitogen-activated protein kinase 14	Homo sapiens	193-196
23732520-4	2013	Consequently, cellular ROS is elevated, leading to the activation of FOXO3a, which contributes to Bim upregulation in Bax/Bak-deficient cells.	ros	23-26	forkhead box O3	Homo sapiens	69-75
23732520-4	2013	Consequently, cellular ROS is elevated, leading to the activation of FOXO3a, which contributes to Bim upregulation in Bax/Bak-deficient cells.	ros	23-26	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
23696052-7	2013	In IGROV-1 cells 5F203-induced ROS formation was accompanied by JNK, ERK and P38MAPK phosphorylation, DNA damage and cell cycle arrest prior to apoptosis.	ros	31-34	mitogen-activated protein kinase 8	Homo sapiens	64-67
23696052-7	2013	In IGROV-1 cells 5F203-induced ROS formation was accompanied by JNK, ERK and P38MAPK phosphorylation, DNA damage and cell cycle arrest prior to apoptosis.	ros	31-34	mitogen-activated protein kinase 1	Homo sapiens	69-72
24086569-10	2013	Inhibition of ROS-induced Smad3 activation by carvedilol resulted in downregulation of Col1a1, Col3a1, and alpha-SMA and upregulation of miR-29b derived from the miR-29b-2 precursor.	ros	14-17	SMAD family member 3	Rattus norvegicus	26-31
23815626-3	2013	In cultured vascular endothelial cells, Ang II stimulation increased ROS generation and inhibited eNOS phosphorylation (Ser1177), both of which were clearly restored by pretreatment with melatonin.	ros	69-72	angiotensinogen	Rattus norvegicus	40-46
23815626-5	2013	In Ang II-infused rats, increased ROS generation in the aortic wall and impaired endothelial function of the aortic ring were observed, which were rescued by coadministration of melatonin.	ros	34-37	angiotensinogen	Rattus norvegicus	3-9
23911867-9	2013	On the other hand, inhibition of ROS not only attenuated high-glucose-mediated T-cell expression of CXCR4 and HIF-1alpha but also mitigated T-cell HIV entry in a high-glucose milieu.	ros	33-36	hypoxia inducible factor 1 subunit alpha	Homo sapiens	110-120
24086569-10	2013	Inhibition of ROS-induced Smad3 activation by carvedilol resulted in downregulation of Col1a1, Col3a1, and alpha-SMA and upregulation of miR-29b derived from the miR-29b-2 precursor.	ros	14-17	collagen type I alpha 1 chain	Rattus norvegicus	87-93
23909664-7	2013	ROS assays showed a high amount of generation of ROS independent of ER status of the cell line indicating changes in mitochondrial membrane fluidity upon the uptake of the conjugate that further leads to the release of cytochrome c, a direct and indirect regulator of ROS.	ros	0-3	cytochrome c, somatic	Homo sapiens	219-231
24086592-4	2013	This ROS release does not induce apoptosis, but instead correlates with stabilization of HIF-1alpha and increased glycolysis.	ros	5-8	hypoxia inducible factor 1 subunit alpha	Homo sapiens	89-99
23909664-7	2013	ROS assays showed a high amount of generation of ROS independent of ER status of the cell line indicating changes in mitochondrial membrane fluidity upon the uptake of the conjugate that further leads to the release of cytochrome c, a direct and indirect regulator of ROS.	ros	49-52	cytochrome c, somatic	Homo sapiens	219-231
23909664-7	2013	ROS assays showed a high amount of generation of ROS independent of ER status of the cell line indicating changes in mitochondrial membrane fluidity upon the uptake of the conjugate that further leads to the release of cytochrome c, a direct and indirect regulator of ROS.	ros	49-52	cytochrome c, somatic	Homo sapiens	219-231
23856293-6	2013	MTR-3 cells with silencing of SIRT3 expression showed increases in the mitochondrial content of ERbeta, ROS level and apoptosis.	ros	104-107	sirtuin 3	Homo sapiens	30-35
23806974-10	2013	These data demonstrate that decreased oxygen utilization in older age could have resulted in decreased mitochondrial ROS-mediated oxidative damage requiring less Sod2 for protection against mitochondrial oxidative stress in older wildtype or older Sod2(+/-) mice.	ros	117-120	superoxide dismutase 2, mitochondrial	Mus musculus	248-252
23958248-2	2013	Optimal activity of iNOS is dependent on the intracellular availability of L-Arg and BH4 via prevention of NOS decoupling and subsequent ROS formation.	ros	137-140	nitric oxide synthase 2	Rattus norvegicus	20-24
23707387-2	2013	Caffeine induced an increase in the intracellular Ca(2+) concentration and ROS generation leading to p38 MAPK activation and ERK inactivation, respectively.	ros	75-78	mitogen-activated protein kinase 14	Homo sapiens	101-104
23707387-2	2013	Caffeine induced an increase in the intracellular Ca(2+) concentration and ROS generation leading to p38 MAPK activation and ERK inactivation, respectively.	ros	75-78	mitogen-activated protein kinase 1	Homo sapiens	125-128
23842789-8	2013	Finally, Sirt3 overexpression upregulated p53 and p21 protein levels, and decreased intracellular ROS levels.	ros	98-101	sirtuin 3	Homo sapiens	9-14
24042587-9	2013	Transfection of ROS 17/2.8 cells with Runx2, Dlx5 or c-Src overexpression plasmid increased the luciferase activities of the constructs, pLUC3 (-116 to +60), pLUC4 (-425 to +60) and pLUC5 (-801 to +60).	ros	16-19	RUNX family transcription factor 2	Rattus norvegicus	38-43
24042587-9	2013	Transfection of ROS 17/2.8 cells with Runx2, Dlx5 or c-Src overexpression plasmid increased the luciferase activities of the constructs, pLUC3 (-116 to +60), pLUC4 (-425 to +60) and pLUC5 (-801 to +60).	ros	16-19	distal-less homeobox 5	Rattus norvegicus	45-49
23908111-2	2013	MPO is a source of ROS during inflammation and can oxidize apolipoprotein A1 (APOA1) of HDL, impairing its atheroprotective functions.	ros	19-22	myeloperoxidase	Homo sapiens	0-3
23378107-6	2013	Pharmacological inhibition of Erk, has totally attenuated MGO-induced ROS production and cytotoxicity, suggesting that MEK/Erk pathway could be upstream of ROS generation and cell survival.	ros	70-73	Eph receptor B1	Rattus norvegicus	30-33
23378107-6	2013	Pharmacological inhibition of Erk, has totally attenuated MGO-induced ROS production and cytotoxicity, suggesting that MEK/Erk pathway could be upstream of ROS generation and cell survival.	ros	70-73	Eph receptor B1	Rattus norvegicus	123-126
23378107-6	2013	Pharmacological inhibition of Erk, has totally attenuated MGO-induced ROS production and cytotoxicity, suggesting that MEK/Erk pathway could be upstream of ROS generation and cell survival.	ros	156-159	Eph receptor B1	Rattus norvegicus	30-33
23378107-6	2013	Pharmacological inhibition of Erk, has totally attenuated MGO-induced ROS production and cytotoxicity, suggesting that MEK/Erk pathway could be upstream of ROS generation and cell survival.	ros	156-159	Eph receptor B1	Rattus norvegicus	123-126
23378107-9	2013	While Erk could be an upstream effector of ROS generation, p38MAPK and JNK seem to be associated with ROS-independent cytotoxicity in neonatal rat brain.	ros	43-46	Eph receptor B1	Rattus norvegicus	6-9
24013271-9	2013	Genipin also blocked the increase of ROS generation induced by TNF-alpha.	ros	37-40	tumor necrosis factor	Homo sapiens	63-72
23860378-8	2013	Similar results were obtained with two divergent oncogenes (RAS and NFkappaB), indicating that ROS production and inflammation metabolically converge on the tumor stroma, driving glycolysis and upregulation of MCT4.	ros	95-98	nuclear factor kappa B subunit 1	Homo sapiens	68-76
24191235-8	2013	These data support distinctive roles for ROS and RNS during H and H/R for Nrf2 induction which are important for survival independently of GSH salvage.	ros	41-44	NFE2 like bZIP transcription factor 2	Homo sapiens	74-78
24353900-6	2013	Hence, prolonged overexpression of TXNIP causes ROS/RNS stress, mitochondrial dysfunction, inflammation and premature cell death in DR.	ros	48-51	thioredoxin interacting protein	Homo sapiens	35-40
23940760-5	2013	We show here that exposure of a human neuroblastoma cell line (SK-N-MC cells) to TNF-alpha promotes ROS-mediated caspase-1 activation and IL-1beta secretion.	ros	100-103	tumor necrosis factor	Homo sapiens	81-90
23940760-5	2013	We show here that exposure of a human neuroblastoma cell line (SK-N-MC cells) to TNF-alpha promotes ROS-mediated caspase-1 activation and IL-1beta secretion.	ros	100-103	caspase 1	Homo sapiens	113-122
23940760-7	2013	The effect of TNF-alpha was abolished in the presence of ROS inhibitors as NAC, or DPI.	ros	57-60	tumor necrosis factor	Homo sapiens	14-23
23915402-10	2013	RESULTS: We found that PCN-generated ROS/RNS caused nitrosylation, acetylation, ubiquitination and degradation of FOXA2.	ros	37-40	forkhead box A2	Mus musculus	114-119
24059789-4	2013	RESULTS: The ability of ESBL strains to evoke ROS-production from PMN cells was significantly higher than that of the non-ESBL strains.	ros	46-49	EsbL	Escherichia coli	24-28
23723060-11	2013	CONCLUSION: Our findings suggest that apoE mediates the effects of leptin on vascular lesion formation by stabilizing cav-1-enriched cell membrane microdomains in SMCs, thus allowing NADPH oxidase assembly and ROS-mediated mitogenic signalling.	ros	210-213	apolipoprotein E	Mus musculus	38-42
23597505-9	2013	Nrf2 nuclear accumulation and increased UCP3 protein were also detected in intact mouse heart subjected to a condition known to increase ROS generation.	ros	137-140	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
23574448-12	2013	Induction of catalase gene expression in NHEM points towards a promelanogenic effect mediated by ROS.	ros	97-100	catalase	Homo sapiens	13-21
23597505-12	2013	In conclusion, we have identified a novel regulatory process induced by an oxidative insult whereby the expression of the mitochondrial protein UCP3 is driven by the Nrf2 transcription factor, which decreases ROS production and prevents cell death.	ros	209-212	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170
23602911-0	2013	Arsenite-induced ROS/RNS generation causes zinc loss and inhibits the activity of poly(ADP-ribose) polymerase-1.	ros	17-20	poly(ADP-ribose) polymerase 1	Homo sapiens	82-111
23602911-4	2013	We report herein that arsenite-generated ROS/RNS inhibits PARP-1 activity in cells.	ros	41-44	poly(ADP-ribose) polymerase 1	Homo sapiens	58-64
23602911-8	2013	These results strongly suggest that cellular generation of ROS/RNS plays an important role in arsenite inhibition of PARP-1 activity, leading to the loss of PARP-1 DNA-binding ability and enzymatic activity.	ros	59-62	poly(ADP-ribose) polymerase 1	Homo sapiens	117-123
23602911-8	2013	These results strongly suggest that cellular generation of ROS/RNS plays an important role in arsenite inhibition of PARP-1 activity, leading to the loss of PARP-1 DNA-binding ability and enzymatic activity.	ros	59-62	poly(ADP-ribose) polymerase 1	Homo sapiens	157-163
22293779-13	2013	CONCLUSIONS: We suggest that hyperglycemia can cause a higher expression of M2-mAChR in cardiomyocytes mainly through ROS to enhance MEK/ERK for phosphorylation of GATA-4.	ros	118-121	Eph receptor B1	Rattus norvegicus	137-140
23696413-4	2013	Pretreatment with SEE significantly restored the content of antioxidant enzymes (SOD1 and catalase) and remarkably inhibited the intracellular ROS concentration in terms of reducing p47phox translocation.	ros	143-146	NSFL1 cofactor	Rattus norvegicus	182-185
22293779-13	2013	CONCLUSIONS: We suggest that hyperglycemia can cause a higher expression of M2-mAChR in cardiomyocytes mainly through ROS to enhance MEK/ERK for phosphorylation of GATA-4.	ros	118-121	GATA binding protein 4	Rattus norvegicus	164-170
23645013-0	2013	Curcumin inhibits LPS-induced inflammation in rat vascular smooth muscle cells in vitro via ROS-relative TLR4-MAPK/NF-kappaB pathways.	ros	92-95	toll-like receptor 4	Rattus norvegicus	105-109
23834359-5	2013	We show that caspase-9 can cleave Bid into tBid at amino acid 59 and that this cleavage of Bid is required for ROS production following serum withdrawal.	ros	111-114	BH3 interacting domain death agonist	Homo sapiens	34-37
23834359-6	2013	We also demonstrate that caspase-3-deficient MEFs are less sensitive to intrinsic cell death stimulation, yet have higher ROS production.	ros	122-125	caspase 3	Homo sapiens	25-34
23834359-8	2013	CONCLUSIONS: Taken together, these data suggest that caspase-9 is required for mitochondrial morphological changes and ROS production by cleaving and activating Bid into tBid.	ros	119-122	BH3 interacting domain death agonist	Homo sapiens	161-164
23834359-9	2013	After activation by caspase-9, caspase-3 inhibits ROS production and is required for efficient execution of apoptosis, while effector caspase-7 is required for apoptotic cell detachment.	ros	50-53	caspase 3	Homo sapiens	31-40
23837608-8	2013	Interestingly, insulin-induced ROS was found responsible for PKM2 activity reduction.	ros	31-34	insulin	Homo sapiens	15-22
23874538-7	2013	CSE up-regulated CCN1 via induction of reactive oxygen spices (ROS) and endoplasmic reticulum (ER) stress.	ros	63-66	cyclin A2	Homo sapiens	17-21
23767415-10	2013	RESULTS: Culture of the KG1a cell line continuously in the presence of an mTOR inhibitor induced features of dormancy including low RNA content, low metabolism and low basal ROS formation in the absence of a DNA damage response or apoptosis.	ros	174-177	mechanistic target of rapamycin kinase	Homo sapiens	74-78
23826082-6	2013	MSCs on FN-Au nanocomposites particularly that containing 43.5 ppm of AuNPs (FN-Au 43.5 ppm) showed cell proliferation, low ROS generation, as well as increases in the protein expression levels of matrix metalloproteinase-9 (MMP-9) and endothelial nitric oxide synthase (eNOS), which may account for the enhanced MSC migration on the nanocomposites.	ros	124-127	fibronectin 1	Homo sapiens	8-10
23826082-6	2013	MSCs on FN-Au nanocomposites particularly that containing 43.5 ppm of AuNPs (FN-Au 43.5 ppm) showed cell proliferation, low ROS generation, as well as increases in the protein expression levels of matrix metalloproteinase-9 (MMP-9) and endothelial nitric oxide synthase (eNOS), which may account for the enhanced MSC migration on the nanocomposites.	ros	124-127	fibronectin 1	Homo sapiens	77-79
23788044-1	2013	FUS1/TUSC2 is a mitochondrial tumor suppressor with activity to regulate cellular oxidative stress by maintaining balanced ROS production and mitochondrial homeostasis.	ros	123-126	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	0-4
23788044-1	2013	FUS1/TUSC2 is a mitochondrial tumor suppressor with activity to regulate cellular oxidative stress by maintaining balanced ROS production and mitochondrial homeostasis.	ros	123-126	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	5-10
23788044-2	2013	Fus1 expression is inhibited by ROS, suggesting that individuals with a high level of ROS may have lower Fus1 in normal tissues and, thus, may be more prone to oxidative stress-induced side effects of cancer treatment, including radiotherapy.	ros	32-35	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	0-4
23788044-2	2013	Fus1 expression is inhibited by ROS, suggesting that individuals with a high level of ROS may have lower Fus1 in normal tissues and, thus, may be more prone to oxidative stress-induced side effects of cancer treatment, including radiotherapy.	ros	32-35	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	105-109
23788044-2	2013	Fus1 expression is inhibited by ROS, suggesting that individuals with a high level of ROS may have lower Fus1 in normal tissues and, thus, may be more prone to oxidative stress-induced side effects of cancer treatment, including radiotherapy.	ros	86-89	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	0-4
23788044-2	2013	Fus1 expression is inhibited by ROS, suggesting that individuals with a high level of ROS may have lower Fus1 in normal tissues and, thus, may be more prone to oxidative stress-induced side effects of cancer treatment, including radiotherapy.	ros	86-89	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	105-109
23921124-7	2013	Our results demonstrate that microRNA-dependent (miRNA-dependent) regulation of the PPP via NRF2 and HDAC4 represents a novel link between miRNA regulation, glucose metabolism, and ROS homeostasis in cancer cells.	ros	181-184	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
23921124-7	2013	Our results demonstrate that microRNA-dependent (miRNA-dependent) regulation of the PPP via NRF2 and HDAC4 represents a novel link between miRNA regulation, glucose metabolism, and ROS homeostasis in cancer cells.	ros	181-184	histone deacetylase 4	Mus musculus	101-106
23727581-9	2013	However, Nec-1, but not BHA, inhibited TNFalpha-induced phosphorylation of RIPK1 in these cells, suggesting that ROS play a crucial role in execution of necroptosis downstream of RIPK1 activation.	ros	113-116	tumor necrosis factor	Homo sapiens	39-47
23755271-8	2013	Taken together, our data demonstrate that ZnO nanoparticles trigger p47(phox) NADPH oxidase-mediated ROS formation in macrophages, but that this is dispensable for caspase-9/3-mediated apoptosis.	ros	101-104	NSFL1 (p97) cofactor (p47)	Mus musculus	68-71
23762310-5	2013	In particular, BLM is able to induce ROS-mediated reticulum stress and autophagy, which result in the surface exposure of chaperones, including calreticulin and ERp57, and liberation of HMBG1 and ATP.	ros	37-40	calreticulin	Homo sapiens	144-156
23762310-5	2013	In particular, BLM is able to induce ROS-mediated reticulum stress and autophagy, which result in the surface exposure of chaperones, including calreticulin and ERp57, and liberation of HMBG1 and ATP.	ros	37-40	protein disulfide isomerase family A member 3	Homo sapiens	161-166
23764845-4	2013	ROS promote nuclear translocation of GAPDH, which is further amplified by AMPK, thereby attenuating glycolysis.	ros	0-3	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	37-42
23591579-8	2013	ROS were also involved in arsenic induced the activation of JNK and p38 MAPK signaling pathway.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	68-71
23526266-5	2013	NPR-A-suppressed adult CF cells exhibited a more pronounced increase in collagen production, ROS generation, and NF-kappaB-p50 nuclear translocation as compared to adult CF cells treated with agonist alone.	ros	93-96	natriuretic peptide receptor 1	Homo sapiens	0-5
23333744-6	2013	The first phase employed the rapid increase in production of ROS as signaling effectors to activate the Nrf2-mediated protective response resulting in up-regulation of the antioxidant proteins, such as NAD(P)H quinone oxidoreductase and gamma-glutamylcysteine synthetase.	ros	61-64	nuclear factor, erythroid derived 2, like 2	Mus musculus	104-108
21656641-6	2013	In the same conditions, Vit E decreased the intracellular level of ROS, reduced PAT induced p53 expression, and reversed PAT induced DNA damage.	ros	67-70	vitrin	Homo sapiens	24-27
23526266-8	2013	The results of this study suggest that ANP/NPR-A signaling system antagonizes the agonist-induced collagen synthesis via suppressing the activities of MMP-2, MMP-9, ROS generation, and NF-kappaB nuclear translocation mechanism.	ros	165-168	natriuretic peptide A	Homo sapiens	39-42
23526266-8	2013	The results of this study suggest that ANP/NPR-A signaling system antagonizes the agonist-induced collagen synthesis via suppressing the activities of MMP-2, MMP-9, ROS generation, and NF-kappaB nuclear translocation mechanism.	ros	165-168	natriuretic peptide receptor 1	Homo sapiens	43-48
23704907-7	2013	In addition to the known mechanism by which SHP modulates innate signaling, we identify a new role of fenofibrate-induced SHP on UCP2 induction, which is required for the suppression of inflammatory responses through modulation of mitochondrial ROS production.	ros	245-248	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	129-133
23828696-4	2013	RESULTS: Isoprenaline significantly promoted fibroblast proliferation and up-regulated collagen (types I and III) and CTGF mRNA expression concomitantly with an increase in ROS production, which were attenuated by CGRP.	ros	173-176	calcitonin related polypeptide alpha	Homo sapiens	214-218
23828696-6	2013	CONCLUSION: CGRP is able to protect cardiac fibroblasts against isoprenaline-induced proliferation and collagen expression, which might be related to the down-regulation of CTGF expression through inhibition of ROS production.	ros	211-214	calcitonin related polypeptide alpha	Homo sapiens	12-16
23738008-9	2013	In contrast, scavenging of extracellular ROS with catalase or the vitamin C analog Asc-2P did not significantly influence the attachment-derived signaling, but caused a selective and pronounced enhancement of ERK1/2 phosphorylation in response to stretching.	ros	41-44	catalase	Homo sapiens	50-58
23738008-9	2013	In contrast, scavenging of extracellular ROS with catalase or the vitamin C analog Asc-2P did not significantly influence the attachment-derived signaling, but caused a selective and pronounced enhancement of ERK1/2 phosphorylation in response to stretching.	ros	41-44	mitogen-activated protein kinase 3	Homo sapiens	209-215
23671702-4	2013	TNF-alphainduced ICAM-1 expression, ROS production, and cell-cell adhesion were significantly attenuated by the pretreatment with antioxidants (DPI, APO, or NAC) and CURN, but not by CURH, as revealed by western blot analysis, RT-PCR, promoter assay, and ROS detection and adhesion assay.	ros	36-39	tumor necrosis factor	Homo sapiens	0-3
23671702-4	2013	TNF-alphainduced ICAM-1 expression, ROS production, and cell-cell adhesion were significantly attenuated by the pretreatment with antioxidants (DPI, APO, or NAC) and CURN, but not by CURH, as revealed by western blot analysis, RT-PCR, promoter assay, and ROS detection and adhesion assay.	ros	255-258	tumor necrosis factor	Homo sapiens	0-3
23092805-12	2013	One may speculate that the Ang-II-mediated loss of muscle force is due to an activation of NAD(P)H oxidase expression and a subsequent ROS-induced down regulation of IGF-1, PGC-1alpha and Sirt1.	ros	135-138	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	27-33
23667638-13	2013	Collectively, elevated homocysteine induced the apoptosis of BMSCs via ROS-induced the activation of JNK signal, which provides more insight into the molecular mechanisms of hyperhomocysteinemia-related cardiovascular diseases.	ros	71-74	mitogen-activated protein kinase 8	Homo sapiens	101-104
23353183-2	2013	At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 prostate cancer cells.	ros	43-46	mitogen-activated protein kinase 8	Homo sapiens	69-72
23353183-2	2013	At higher concentrations, curcumin induced ROS production leading to JNK and p38 phosphorylation in DU-145 prostate cancer cells.	ros	43-46	mitogen-activated protein kinase 14	Homo sapiens	77-80
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	ros	239-242	mitogen-activated protein kinase 1	Homo sapiens	20-23
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	ros	239-242	mitogen-activated protein kinase 14	Homo sapiens	27-30
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	ros	239-242	mitogen-activated protein kinase 8	Homo sapiens	31-34
23353183-3	2013	Of the MAP kinases, ERK or p38/JNK were phosphorylated earlier during curcumin treatment, and were responsible for curcumin-induced cell survival at early time of treatment with the help of phosphorylated Akt, while significant amounts of ROS production in later periods stimulated cell death with caspase degradation.	ros	239-242	AKT serine/threonine kinase 1	Homo sapiens	205-208
23707880-8	2013	CONCLUSIONS: These results suggest that the anti-inflammatory properties of benazepril may be ascribed to their down-regulation of both NF-kappaB and TGF-beta signaling pathways by acting on the intracellular ROS production in rats with LV hypertrophy, thus supporting the use of benazepril as an anti-inflammatory agent.	ros	209-212	transforming growth factor, beta 1	Rattus norvegicus	150-158
23574722-7	2013	siRNA-mediated depletion of GLS2 sensitizes cells to ROS-induced apoptosis, suggesting that the TAp63/GLS2 axis can be functionally important as a cellular antioxidant pathway in the absence of p53.	ros	53-56	glutaminase 2	Homo sapiens	28-32
23574722-7	2013	siRNA-mediated depletion of GLS2 sensitizes cells to ROS-induced apoptosis, suggesting that the TAp63/GLS2 axis can be functionally important as a cellular antioxidant pathway in the absence of p53.	ros	53-56	glutaminase 2	Homo sapiens	102-106
23574722-7	2013	siRNA-mediated depletion of GLS2 sensitizes cells to ROS-induced apoptosis, suggesting that the TAp63/GLS2 axis can be functionally important as a cellular antioxidant pathway in the absence of p53.	ros	53-56	tumor protein p53	Homo sapiens	194-197
23416140-8	2013	In conclusion, the JNK and p38 MAPK pathways might be critical mediators in CPF-induced neuronal apoptosis by both generating ROS and up-regulating COX-2.	ros	126-129	mitogen-activated protein kinase 8	Homo sapiens	19-22
23416112-7	2013	Furthermore, the CKB knockdown reduced glucose consumption and lactate production, and increased ROS production and oxygen consumption.	ros	97-100	creatine kinase B	Homo sapiens	17-20
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	ros	117-120	caspase 3	Homo sapiens	186-195
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	ros	117-120	BCL2 apoptosis regulator	Homo sapiens	200-205
23416140-8	2013	In conclusion, the JNK and p38 MAPK pathways might be critical mediators in CPF-induced neuronal apoptosis by both generating ROS and up-regulating COX-2.	ros	126-129	mitogen-activated protein kinase 1	Homo sapiens	27-30
23343509-11	2013	Our results support the notion that GLP1 receptor agonists restore eNOS-induced ROS production due to lipotoxicity and that such agonists protect against lipoapoptosis through PKA-PI3K/Akt-eNOS-p38 MAPK-JNK-dependent pathways via a GLP1 receptor-dependent mechanism.	ros	80-83	nitric oxide synthase 3	Homo sapiens	67-71
23547843-7	2013	Interestingly, 2 showed antioxidant activity by inhibition of ROS generation to 50% at 33.3 muM in PMA-induced HL-60 cells, while 1 was inactive at 100 muM (vs Trolox 1.4 muM).	ros	62-65	latexin	Homo sapiens	92-95
23318226-6	2013	Moreover, ATPgammaS-induced STAT3 phosphorylation and translocation was inhibited by pretreatment with the inhibitors of PKC, NADPH oxidase, and ROS.	ros	145-148	signal transducer and activator of transcription 3	Homo sapiens	28-33
23318226-10	2013	These results suggested that ATPgammaS-induced cPLA2/COX-2 expression and PGE2 secretion is mediated through a PKC/NADPH oxidase/ROS/STAT3-dependent pathway in VSMCs.	ros	129-132	prostaglandin-endoperoxide synthase 2	Homo sapiens	53-58
23369747-10	2013	Both NF-kappaB inhibitor and ROS scavenger could inhibit the enhancement of LPS-induced TLR2 expression and inflammatory cytokine secretion under high glucose conditions.	ros	29-32	toll like receptor 2	Homo sapiens	88-92
23499005-4	2013	Moreover, B55alpha is specifically induced upon glutamine deprivation in a ROS-dependent manner to activate p53 and promote cell survival.	ros	75-78	tumor protein p53	Homo sapiens	108-111
22960642-4	2013	Presently, research in a number of laboratories is focused on RyR phosphorylation, both by PKA and CaMKII, or on RyR modifications caused by reactive oxygen and nitrogen species (ROS/RNS).	ros	179-182	ryanodine receptor 1	Homo sapiens	113-116
22627996-9	2013	In conclusion, xanthorrhizol may induce caspase-independent apoptosis through ROS-mediated p38 MAPK and JNK activation in SCC-15 OSCC cells and prevent chemical-induced oral carcinogenesis.	ros	78-81	mitogen-activated protein kinase 14	Homo sapiens	91-94
22627996-9	2013	In conclusion, xanthorrhizol may induce caspase-independent apoptosis through ROS-mediated p38 MAPK and JNK activation in SCC-15 OSCC cells and prevent chemical-induced oral carcinogenesis.	ros	78-81	mitogen-activated protein kinase 8	Homo sapiens	104-107
23376140-5	2013	ROS produced by this oxidase activates Src, enable that in turn, transactivates EGFR that activates Stat3 in tyrosine, allowing its dimerization.	ros	0-3	signal transducer and activator of transcription 3	Mus musculus	100-105
23376140-6	2013	Also, ROS from NADPH oxidase favors ERK1/2 activation that phosphorylates Stat3 in serine, resulting in a compensatory or adaptive survival response such as production of metallothionein-II in short Cd exposure times.	ros	6-9	signal transducer and activator of transcription 3	Mus musculus	74-79
23376140-6	2013	Also, ROS from NADPH oxidase favors ERK1/2 activation that phosphorylates Stat3 in serine, resulting in a compensatory or adaptive survival response such as production of metallothionein-II in short Cd exposure times.	ros	6-9	metallothionein 2	Mus musculus	171-189
23266625-4	2013	Protamine (71.35 ng/ml) increased BSP mRNA levels by 6h in osteoblast-like ROS 17/2.8 cells.	ros	75-78	integrin-binding sialoprotein	Rattus norvegicus	34-37
23434597-3	2013	identify STIM1, an ER calcium sensor, as a key link between LPS-induced ROS, calcium oscillations, and endothelial cell (EC) dysfunction.	ros	72-75	stromal interaction molecule 1	Homo sapiens	9-14
23261989-3	2013	IGF-1 dose- and time- dependently reduced basal- and oxLDL-induced ROS generation.	ros	67-70	insulin like growth factor 1	Homo sapiens	0-5
23232839-0	2013	Endothelial dysfunction in diabetes and hypertension: cross talk in RAS, BMP4, and ROS-dependent COX-2-derived prostanoids.	ros	83-86	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	97-102
23220614-8	2013	Furthermore, the ROS inhibitor (NAC) notably promoted the inhibited effect of ISO on the ERK1/2 kinase.	ros	17-20	mitogen-activated protein kinase 3	Homo sapiens	89-95
23220614-10	2013	These results demonstrated for the first time that ISO induces apoptosis in HepG2 cells through inactivating ERK1/2 kinase and activating JNK and p38 kinases, and ROS stimulated by ISO is able to activate the MAPK singaling pathway as the upstream signaling molecules.	ros	163-166	mitogen-activated protein kinase 8	Homo sapiens	138-141
23220614-10	2013	These results demonstrated for the first time that ISO induces apoptosis in HepG2 cells through inactivating ERK1/2 kinase and activating JNK and p38 kinases, and ROS stimulated by ISO is able to activate the MAPK singaling pathway as the upstream signaling molecules.	ros	163-166	mitogen-activated protein kinase 1	Homo sapiens	146-149
23220614-10	2013	These results demonstrated for the first time that ISO induces apoptosis in HepG2 cells through inactivating ERK1/2 kinase and activating JNK and p38 kinases, and ROS stimulated by ISO is able to activate the MAPK singaling pathway as the upstream signaling molecules.	ros	163-166	mitogen-activated protein kinase 3	Homo sapiens	209-213
23041058-4	2013	These defense enzymes mediated by Nrf2-antioxidative stress and anti-inflammatory signaling pathways can contribute to cellular protection against ROS/RNS and reactive metabolites of carcinogens.	ros	147-150	NFE2 like bZIP transcription factor 2	Homo sapiens	34-38
23054367-7	2013	Conversely, ethanol-induced ROS generation was inhibited if VDR was activated or Ang II was blocked by an angiotensin II type 1 (AT1) receptor blocker (Losartan).	ros	28-31	angiotensinogen	Homo sapiens	81-87
23395165-2	2013	A new study shows that, upon serine starvation, the tumor suppressor p53 activates p21 to shift metabolic flux from purine biosynthesis to glutathione production, which enhances cellular proliferation and viability by combating ROS (Maddocks et al., 2013).	ros	228-231	tumor protein p53	Homo sapiens	69-72
23252827-3	2013	Knockdown of individual components or of the entire miR-183/96/182 cluster inhibits the survival of glioma cells by regulating the ROS-induced apoptosis pathway.	ros	131-134	microRNA 183	Homo sapiens	52-59
23252827-4	2013	Furthermore, inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes.	ros	62-65	microRNA 183	Homo sapiens	31-38
23252827-4	2013	Furthermore, inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes.	ros	62-65	AKT serine/threonine kinase 1	Homo sapiens	75-78
23252827-4	2013	Furthermore, inhibition of the miR-183/96/182 cluster induced ROS-mediated AKT/survival independent of three target genes FGF9, CPEB1, and FOXO1, and inhibition of the miRNA cluster induced p53/apoptosis signaling, which was dependent on these same genes.	ros	62-65	tumor protein p53	Homo sapiens	190-193
23252827-5	2013	In addition, knockdown of the miR-183/96/182 cluster enhanced the anticancer effect of Temozolomide on glioma cells by the ROS-mediated apoptosis pathway.	ros	123-126	microRNA 183	Homo sapiens	30-37
22903504-8	2013	Notably, LPS-induced ROS generation can partly facilitate p38 MAPK/JNK/AKT activation to regulate GSK-3beta-mediated Mcl-1 stability, apoptosis, and neutrophilia.	ros	21-24	thymoma viral proto-oncogene 1	Mus musculus	71-74
23123564-5	2013	VIP enhanced ROS levels and decreased nuclear levels of beta-catenin and NFkappaB p50-subunit in A498 cells, suggesting neuropeptide involvement in the observed decrease of metastatic ability in clear-cell carcinoma.	ros	13-16	vasoactive intestinal peptide	Homo sapiens	0-3
23668019-12	2013	Biological feature of HSCs in aging group with X-ray irradiation as follows: The percentage of SA-beta-Gal positive cells, the ratio of G1 stages and the production of ROS were significantly increased , the expression of p16 in mRNA level was also upregulated.	ros	168-171	cytochrome P450, family 2, subfamily b, polypeptide 10	Mus musculus	221-224
23085193-3	2013	Then, it will focus on new findings on the molecular mechanisms of how TNF triggers activation of the NF-kappaB and AP-1 pathways, which are critical for expression of pro-inflammatory cytokines, as well as the MLKL cascade, which is critical for the generation of ROS in response to TNF.	ros	265-268	tumor necrosis factor	Homo sapiens	71-74
23509682-7	2013	ROS formation seems important for PM10-induced IL-1beta response, but further investigations are needed to elucidate the molecular pathway by which this effect is mediated.	ros	0-3	interleukin 1 beta	Homo sapiens	47-55
23144312-2	2013	Since increased production of ROS is implicated in the development of left ventricular hypertrophy, we hypothesized that the redox activity of MIF protects the myocardium when exposed to hemodynamic stress.	ros	30-33	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	143-146
23287470-0	2013	A novel link between p53 and ROS.	ros	29-32	tumor protein p53	Homo sapiens	21-24
23247593-12	2013	CONCLUSION: In U266 cells, berberine suppresses NF-kappaB nuclear translocation via Set9-mediated lysine methylation, leads to decrease in the levels miR21 and Bcl-2, which induces ROS generation and apoptosis.	ros	181-184	BCL2 apoptosis regulator	Homo sapiens	160-165
24369528-4	2013	hMSC injection induced a decrease in transaminases levels and oxidative stress, a disappearance of apoptotic cells, and an increase in Nrf2, SOD gene expression, which might reduce ROS production in the injured liver.	ros	181-184	NFE2 like bZIP transcription factor 2	Homo sapiens	135-139
24216696-5	2013	HIF-1a activation has been also reported to occur via hypoxia-independent mechanisms such as PI3K/AKT/mTOR signaling and ROS production.	ros	121-124	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-6
23046812-11	2013	Our findings suggest that increased intracellular ROS levels might modulate the expression of Sirt3 which deacetylates and activates F(o)F(1)ATPase in human cells with mitochondrial dysfunction caused by a pathogenic mtDNA mutation.	ros	50-53	sirtuin 3	Homo sapiens	94-99
23861715-7	2013	Administration of QSYQ could attenuate LAD-induced HF, and AngII-NOX2-ROS-MMPs pathway seemed to be the critical potential targets for QSYQ to reduce the remodeling.	ros	70-73	angiotensinogen	Rattus norvegicus	59-64
23733672-0	2013	Surfactin-induced apoptosis through ROS-ERS-Ca2+-ERK pathways in HepG2 cells.	ros	36-39	mitogen-activated protein kinase 1	Homo sapiens	49-52
23733672-7	2013	According to a comprehensive review of all the evidence, it is concluded that surfactin induces apoptosis of HepG2 cells through a ROS-ERS-Ca(2+) mediated ERK pathway.	ros	131-134	mitogen-activated protein kinase 1	Homo sapiens	155-158
23085260-4	2013	In EC, HG induced CIKS mRNA and protein expression via DPI-inhibitable Nox4-dependent ROS generation.	ros	86-89	TRAF3 interacting protein 2	Mus musculus	18-22
23085260-5	2013	Further, HG induced CIKS transcription and enhanced CIKS promoter-dependent reporter gene activation via Nox4, ROS, AP-1 and C/EBP.	ros	111-114	TRAF3 interacting protein 2	Mus musculus	52-56
23843863-9	2013	S-[6]-Gingerol attenuated IL1beta-induced inflammation and oxidative stress in HuH7 cells, as evidenced by decreasing mRNA levels of inflammatory factor IL6, IL8, and SAA1, suppression of ROS generation, and increasing mRNA levels of DHCR24.	ros	188-191	interleukin 1 beta	Homo sapiens	26-33
23323617-6	2013	In the current study, we explored the protective effect of PPARgamma ligands on cardiomyocyte I(to) by preventing NADPH Oxidase activation and the ensuing ROS formation.	ros	155-158	peroxisome proliferator activated receptor gamma	Homo sapiens	59-68
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	ros	150-153	interleukin 1 beta	Homo sapiens	87-94
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	ros	150-153	nuclear factor kappa B subunit 1	Homo sapiens	154-164
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	ros	150-153	prostaglandin-endoperoxide synthase 2	Homo sapiens	165-169
23758151-0	2013	Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS-mediated MAPK pathways.	ros	99-102	mitogen-activated protein kinase 1	Homo sapiens	112-116
24092346-10	2013	Enzymatic sources of ROS in PH that have been identified include the NAPDPH oxidases 1, 2, and 4, xanthine oxidase, uncoupled eNOS, and complex III of the mitochondrial electron transport chain.	ros	21-24	nitric oxide synthase 3	Homo sapiens	126-130
21741805-5	2013	This effect resulted from an elevation in ROS generation by TNF-alpha, while a compensatory upregulation of protective molecules (H-ferritin and/or reduced glutathione) by TNF-alpha was absent.	ros	42-45	tumor necrosis factor	Mus musculus	60-69
23063593-6	2013	Furthermore, the addition of a ROS inhibitor (N-Acetyl-l-cysteine, NAC) significantly attenuated the apoptosis induced by HER and also blocked the expression of PGC-1alpha protein.	ros	31-34	PPARG coactivator 1 alpha	Homo sapiens	161-171
23063593-8	2013	These findings provide evidences that HER induces HepG2 apoptosis in a ROS-mediated mitochondria-dependent manner that correlate with the inactivation of the PI3K/Akt pathway.	ros	71-74	AKT serine/threonine kinase 1	Homo sapiens	163-166
23950593-10	2013	CONCLUSIONS: These results suggested that BDMC-induced ROS accumulation may contribute to its inhibitory effect on MCF-7 cell viability through regulation of p53/p21 and p16/Rb pathways.	ros	55-58	tumor protein p53	Homo sapiens	158-161
24454979-0	2013	Carbon monoxide protects against hepatic ischemia/reperfusion injury via ROS-dependent Akt signaling and inhibition of glycogen synthase kinase 3beta.	ros	73-76	thymoma viral proto-oncogene 1	Mus musculus	87-90
24454989-0	2013	Astragalus polysaccharide suppresses skeletal muscle myostatin expression in diabetes: involvement of ROS-ERK and NF-kappaB pathways.	ros	102-105	mitogen-activated protein kinase 1	Mus musculus	106-109
24454989-10	2013	APS is capable of improving insulin sensitivity and decreasing myostatin expression in skeletal muscle through downregulating ROS-ERK-NF-kappaB pathway.	ros	126-129	mitogen-activated protein kinase 1	Mus musculus	130-133
24145084-10	2013	CONCLUSION: ET-1-induced formation of ROS in the heart is at least partially regulated via NADPH oxidase.	ros	38-41	endothelin 1	Rattus norvegicus	12-16
23950593-10	2013	CONCLUSIONS: These results suggested that BDMC-induced ROS accumulation may contribute to its inhibitory effect on MCF-7 cell viability through regulation of p53/p21 and p16/Rb pathways.	ros	55-58	cyclin dependent kinase inhibitor 2A	Homo sapiens	170-173
23441212-7	2013	Furthermore, the inhibition of autophagy also stimulated ROS formation and scavenging of ROS by antioxidant NAC inhibited caspase-3 activity, prevented the release of cyt-c from mitochondria and eventually rescued cancer cells from 5-FU-mediated apoptosis.	ros	89-92	caspase 3	Homo sapiens	122-131
23516464-5	2013	Moreover, the increase in NOX 2 and NOX 4 mRNA levels, NADPH oxidase activity, and ROS levels induced by PRR over-expression was prevented by mitogen activated protein kinase/extracellular signal-regulated kinase 1 and 2 (MAPK/ERK1/2) inhibition, and phosphoinositide 3 kinase/Akt (IP3/Akt) inhibition, indicating that PRR regulates NOX activity and ROS formation in neuro-2A cells through Ang II-independent ERK1/2 and IP3/Akt activation.	ros	83-86	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	105-108
23516464-5	2013	Moreover, the increase in NOX 2 and NOX 4 mRNA levels, NADPH oxidase activity, and ROS levels induced by PRR over-expression was prevented by mitogen activated protein kinase/extracellular signal-regulated kinase 1 and 2 (MAPK/ERK1/2) inhibition, and phosphoinositide 3 kinase/Akt (IP3/Akt) inhibition, indicating that PRR regulates NOX activity and ROS formation in neuro-2A cells through Ang II-independent ERK1/2 and IP3/Akt activation.	ros	350-353	ATPase, H+ transporting, lysosomal accessory protein 2	Mus musculus	105-108
23516464-7	2013	In conclusion, human PRR over-expression induced ROS production through both angiotensin II-dependent and -independent mechanisms.	ros	49-52	angiotensinogen	Homo sapiens	77-91
23516464-8	2013	We showed that PRR-mediated angiotensin II-independent ROS formation is associated with activation of the MAPK/ERK1/2 and PI3/Akt signaling pathways and up-regulation of mRNA level of NOX 2 and NOX4 isoforms in neuronal cells.	ros	55-58	angiotensinogen	Homo sapiens	28-42
23516464-8	2013	We showed that PRR-mediated angiotensin II-independent ROS formation is associated with activation of the MAPK/ERK1/2 and PI3/Akt signaling pathways and up-regulation of mRNA level of NOX 2 and NOX4 isoforms in neuronal cells.	ros	55-58	mitogen-activated protein kinase 3	Homo sapiens	111-117
23027708-7	2013	ROS-associated chemotherapy related ApoA-I oxidation leads to elevation of peripheral levels of tumor necrosis factor-alpha (TNF-alpha) that can cross the blood-brain barrier (BBB) causing a signaling cascade that can contribute to neuronal death, likely a contributor to what patients refer to as "chemobrain."	ros	0-3	apolipoprotein A1	Homo sapiens	36-42
23516464-8	2013	We showed that PRR-mediated angiotensin II-independent ROS formation is associated with activation of the MAPK/ERK1/2 and PI3/Akt signaling pathways and up-regulation of mRNA level of NOX 2 and NOX4 isoforms in neuronal cells.	ros	55-58	thymoma viral proto-oncogene 1	Mus musculus	126-129
23437333-0	2013	Sensitivity of malignant peripheral nerve sheath tumor cells to TRAIL is augmented by loss of NF1 through modulation of MYC/MAD and is potentiated by curcumin through induction of ROS.	ros	180-183	TNF superfamily member 10	Homo sapiens	64-69
23457492-5	2013	Moreover, VCP knockdown decreased intracellular ROS levels in normal and H2O2-treated cells, and an oxidation-resistant VCP impaired the ROS-induced cytoplasmic redistribution of catalase.	ros	137-140	catalase	Homo sapiens	179-187
23326583-7	2013	Moreover, ATPgammaS-induced ROS generation and p47(phox) translocation was also reduced by pretreatment with the inhibitors of P2 receptor, PKC, and NADPH oxidase.	ros	28-31	protein kinase C alpha	Homo sapiens	140-143
23326583-9	2013	SIGNIFICANCE: Taken together, these results showed that ATPgammaS induced COX-2 expression and PGE(2) production via a P2 receptor/PKC/NADPH oxidase/ROS/Jak2/STAT3/cPLA(2) signaling pathway in A549 cells.	ros	149-152	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
23326583-9	2013	SIGNIFICANCE: Taken together, these results showed that ATPgammaS induced COX-2 expression and PGE(2) production via a P2 receptor/PKC/NADPH oxidase/ROS/Jak2/STAT3/cPLA(2) signaling pathway in A549 cells.	ros	149-152	signal transducer and activator of transcription 3	Homo sapiens	158-163
23219970-3	2013	In this study we observed that the CB1 and CB2 receptor non-selective or selective agonists dramatically attenuate iNOS induction and ROS generation in LPS-activated microglia.	ros	134-137	cannabinoid receptor 1	Homo sapiens	35-38
23027708-7	2013	ROS-associated chemotherapy related ApoA-I oxidation leads to elevation of peripheral levels of tumor necrosis factor-alpha (TNF-alpha) that can cross the blood-brain barrier (BBB) causing a signaling cascade that can contribute to neuronal death, likely a contributor to what patients refer to as "chemobrain."	ros	0-3	tumor necrosis factor	Homo sapiens	96-123
23027708-7	2013	ROS-associated chemotherapy related ApoA-I oxidation leads to elevation of peripheral levels of tumor necrosis factor-alpha (TNF-alpha) that can cross the blood-brain barrier (BBB) causing a signaling cascade that can contribute to neuronal death, likely a contributor to what patients refer to as "chemobrain."	ros	0-3	tumor necrosis factor	Homo sapiens	125-134
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	12-15	B cell leukemia/lymphoma 2	Mus musculus	93-98
23601165-4	2013	Interferon-gamma is the most potent inducer of ROS-RNS formation in target cells like macrophages.	ros	47-50	interferon gamma	Homo sapiens	0-16
23400923-4	2013	These results strongly implicate the susceptibility of PON1 to increased ROS production.	ros	73-76	paraoxonase 1	Homo sapiens	55-59
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	12-15	B cell leukemia/lymphoma 2	Mus musculus	228-233
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	B cell leukemia/lymphoma 2	Mus musculus	93-98
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	B cell leukemia/lymphoma 2	Mus musculus	228-233
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	B cell leukemia/lymphoma 2	Mus musculus	93-98
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	B cell leukemia/lymphoma 2	Mus musculus	228-233
22847064-5	2012	In this study, we observed that LOX-1 expression is induced upon toxic microglial activation, and discovered that LOX-1 is necessary in microglia for sensing soluble neuronal injury signal(s) in the conditioned medium to induce generation of pro-inflammatory mediators (IL-1beta, TNF-alpha, NO and ROS) that promote neurotoxicity.	ros	298-301	interleukin 1 beta	Homo sapiens	270-278
23010494-6	2012	Increased ROS production occurred in a dose-dependent manner especially in the presence of rotenone (complex I inhibitor), which was significantly more prominent in arachidonic acid at 80 muM (+970%, P&lt;0.001) than palmitic acid (+40%, P&lt;0.01).	ros	10-13	latexin	Homo sapiens	188-191
22996042-7	2012	Loss of TLR2-mediated immune activity and senescence leads to the attenuation of autophagic flux, which cannot eliminate SQSTM1 aggregates, ROS accumulation, and DNA damage, and facilitates the development and progression of HCC.	ros	140-143	toll like receptor 2	Homo sapiens	8-12
22736026-10	2012	CONCLUSIONS: Our study first found that beta-elemene could increase the expression of HIF-1alpha through ROS and PI3K/Akt/mTor signaling pathway.	ros	105-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	86-96
22951908-3	2012	The most important reactive oxygen/nitrogen species (ROS/RNS) detoxification mechanisms include superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx).	ros	53-56	catalase	Homo sapiens	124-132
22915768-10	2012	Vinpocetine powerfully attenuated intracellular reactive oxidative species (ROS) production, which largely mediates the inhibitory effects of vinpocetine on ERK1/2 activation and SMC growth.	ros	76-79	mitogen-activated protein kinase 3	Homo sapiens	157-163
23041291-3	2012	Tie2-CYP2J2-Tr mice had significantly increased CYP2J2 expression, increased 14,15-EET production, increases regional cerebral blood flow (rCBF) and microvascular density, decreased ROS production, decreased brain infarct size and apoptosis after ischemia compared to wild type mice, these were associated with increased activation of the PI3K/AKT and apoptosis-related protein in ischemic brain.	ros	182-185	TEK receptor tyrosine kinase	Mus musculus	0-4
22881126-7	2012	Then after administration of ERK, JNK and P38 inhibitors, only JNK inhibitor SP600125 effectively augmented oridonin-induced apoptosis and ROS generation.	ros	139-142	mitogen-activated protein kinase 8	Homo sapiens	63-66
22881126-10	2012	Inhibition of EGFR augmented oridonin-induced apoptosis and this was caused by enhanced oxidative stress, and JNK played a major protective role by increasing autophagy, leading to antagonising apoptosis and ROS generation.	ros	208-211	epidermal growth factor receptor	Homo sapiens	14-18
22881126-10	2012	Inhibition of EGFR augmented oridonin-induced apoptosis and this was caused by enhanced oxidative stress, and JNK played a major protective role by increasing autophagy, leading to antagonising apoptosis and ROS generation.	ros	208-211	mitogen-activated protein kinase 8	Homo sapiens	110-113
22564432-7	2012	Cell loading with dihydrorhodamine 123 revealed EGCG-induced ROS production, prevented by CAT, mibefradil or the Ca(2+)  chelator BAPTA-AM.	ros	61-64	catalase	Homo sapiens	90-93
22895655-6	2012	Pretreatment with NAC slightly inhibited the expression levels of c-FLIPL             downregulated by the treatment of dioscin, suggesting that dioscin is partially             dependent on the generation of ROS for downregulation of c-FLIPL.	ros	209-212	CASP8 and FADD like apoptosis regulator	Homo sapiens	66-73
22895655-6	2012	Pretreatment with NAC slightly inhibited the expression levels of c-FLIPL             downregulated by the treatment of dioscin, suggesting that dioscin is partially             dependent on the generation of ROS for downregulation of c-FLIPL.	ros	209-212	CASP8 and FADD like apoptosis regulator	Homo sapiens	235-242
23117583-18	2012	Comparing bioluminescence in wildtype mice to p47(phox-/-) mice enables us to delineate the specific contribution of ROS generated by p47(phox)-containing NADPH oxidase to the bioluminescent signal in these models.	ros	117-120	NSFL1 (p97) cofactor (p47)	Mus musculus	134-137
23117583-19	2012	Bioluminescence imaging results that demonstrated increased ROS levels in wildtype mice compared to p47(phox-/-) mice indicated that NADPH oxidase is the major source of ROS generation in response to inflammatory stimuli.	ros	170-173	NSFL1 (p97) cofactor (p47)	Mus musculus	100-103
23117583-18	2012	Comparing bioluminescence in wildtype mice to p47(phox-/-) mice enables us to delineate the specific contribution of ROS generated by p47(phox)-containing NADPH oxidase to the bioluminescent signal in these models.	ros	117-120	NSFL1 (p97) cofactor (p47)	Mus musculus	46-49
22982676-13	2012	CONCLUSION: This study demonstrates that palmitate induces ROS production and that the palmitate induced lipotoxicity is the result of increased ROS production, where the ROS sensitive MKK3/6-p38 pathway mediates lipoapoptosis of GLP-1-secreting cells.	ros	145-148	mitogen-activated protein kinase kinase 3	Mus musculus	185-189
22910329-0	2012	Mitochondrial aquaporin-8 knockdown in human hepatoma HepG2 cells causes ROS-induced mitochondrial depolarization and loss of viability.	ros	73-76	aquaporin 8	Homo sapiens	14-25
22982676-13	2012	CONCLUSION: This study demonstrates that palmitate induces ROS production and that the palmitate induced lipotoxicity is the result of increased ROS production, where the ROS sensitive MKK3/6-p38 pathway mediates lipoapoptosis of GLP-1-secreting cells.	ros	145-148	mitogen-activated protein kinase kinase 3	Mus musculus	185-189
23045975-5	2012	In vitro findings revealed that pretreatment with Tbeta4 resulted in reduction of intracellular ROS in the cardiac fibroblasts and was associated with increased expression of antioxidant enzymes, reduction of Bax/Bcl(2) ratio, and attenuation of profibrotic genes.	ros	96-99	thymosin beta 4 X-linked	Homo sapiens	50-56
22895800-0	2012	Involvement of ROS in the inhibitory effect of thermotherapy combined             with chemotherapy on A549 human lung adenocarcinoma cell growth through the Akt             pathway.	ros	15-18	AKT serine/threonine kinase 1	Homo sapiens	158-161
22822009-4	2012	The antimicrobial activity of macrophages, including ROS production, is greatly enhanced by IFN-gamma, but how this is achieved is incompletely understood.	ros	53-56	interferon gamma	Mus musculus	92-101
22822009-6	2012	We found that enhanced capacity for ROS production is, in part, a result of increased protein expression of gp91(phox) and p22(phox) but also demonstrate that IFN-gamma induced a shift in the predominant localization of gp91(phox) and p22(phox) from intracellular membrane compartments to the PM.	ros	36-39	dynein cytoplasmic 1 heavy chain 1	Mus musculus	123-126
22822009-6	2012	We found that enhanced capacity for ROS production is, in part, a result of increased protein expression of gp91(phox) and p22(phox) but also demonstrate that IFN-gamma induced a shift in the predominant localization of gp91(phox) and p22(phox) from intracellular membrane compartments to the PM.	ros	36-39	interferon gamma	Mus musculus	159-168
22822009-6	2012	We found that enhanced capacity for ROS production is, in part, a result of increased protein expression of gp91(phox) and p22(phox) but also demonstrate that IFN-gamma induced a shift in the predominant localization of gp91(phox) and p22(phox) from intracellular membrane compartments to the PM.	ros	36-39	dynein cytoplasmic 1 heavy chain 1	Mus musculus	235-238
22842544-6	2012	Pretreatment with N-acetyl-l-cysteine (NAC) partly recovered the expression levels of c-FLIPL and c-FLIPs proteins were downregulated by the AMA treatment, suggesting that AMA appears to be partially dependent on the generation of ROS for downregulation of c-FLIPL and c-FLIPs.	ros	231-234	CASP8 and FADD like apoptosis regulator	Homo sapiens	86-93
22766494-7	2012	We next demonstrated that ar-turmerone induced HO-1 and Nrf-2 activation suppressed the activation of neuroinflammatory molecules in LPS-induced microglial cells, and that down-regulation of HO-1 signals was sufficient to induce the expression of iNOS, COX-2 and ROS production in microglial cells.	ros	263-266	heme oxygenase 1	Mus musculus	191-195
22898050-14	2012	Inhibiting AMPK and PTEN restored ROS levels stimulated with TNF-alpha.	ros	34-37	tumor necrosis factor	Homo sapiens	61-70
22634758-0	2012	Inhibition of ROS-induced p38MAPK and ERK activation in microglia by acupuncture relieves neuropathic pain after spinal cord injury in rats.	ros	14-17	Eph receptor B1	Rattus norvegicus	38-41
22921415-4	2012	Our data provide a mechanistic foundation to explain how an optimal level of an often vilified ROS-generating compound such as hydrogen peroxide can provide cellular benefit, a phenomenon described as hormesis, by instructing cells to readjust their lipid biosynthetic capacity through downstream HIF-1 activation to correct cellular energy deficiencies.	ros	95-98	Hypoxia-inducible factor 1	Caenorhabditis elegans	297-302
22634610-3	2012	Our results outline a significant increase in the ROS generation accompanied by a decrease in the histone H3 acetylation, H3 Ser-10 phosphorylation, H3K4 methylation and an increase in the H3K9 methylation, after 30 min of insulin treatment under hyperglycemic condition.	ros	50-53	insulin	Homo sapiens	223-230
22634610-4	2012	However, after 12h of insulin treatment a reversal of these histone H3 modifications was observed which commensurate with the reduced ROS generation.	ros	134-137	insulin	Homo sapiens	22-29
22659450-0	2012	The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation.	ros	45-48	extended synaptotagmin 1	Homo sapiens	96-102
22659450-7	2012	Expression of CD74-ROS resulted in the phosphorylation of the extended synaptotagmin-like protein E-Syt1.	ros	19-22	extended synaptotagmin 1	Homo sapiens	98-104
22659450-9	2012	Furthermore, expression of CD74-ROS in noninvasive NSCLC cell lines readily conferred invasive properties that paralleled the acquisition of E-Syt1 phosphorylation.	ros	32-35	extended synaptotagmin 1	Homo sapiens	141-147
22709785-8	2012	Naringenin also blocked the increase of ROS generation induced by TNF-alpha.	ros	40-43	tumor necrosis factor	Rattus norvegicus	66-75
22753949-3	2012	TRPV1-dependent autophagy required [Ca(2+)](i) and ROS generation, resulting in AMPK activation.	ros	51-54	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22753949-5	2012	TRPV1-triggered autophagy was Atg6/Beclin-1-dependent, as demonstrated by the use of Beclin-1(+/-) transgenic mice, and involved ROS- and AMPK-mediated up-regulation of Beclin-1 expression.	ros	129-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22710948-5	2012	The results presented             in this study are discussed taking into consideration the relationship of hypercholesterolemia,             27OHC production, ROS synthesis and macrophage infiltration, potentially occurring             in obese patients with ERalpha-positive, infiltrated mammary tumors.	ros	160-163	estrogen receptor 1	Homo sapiens	260-267
22634758-10	2012	Furthermore, ROS produced after injury-induced p38MAPK and ERK activation in microglia, and mediated mechanical allodynia and thermal hyperalgesia, which were inhibited by AP or a ROS scavenger.	ros	13-16	Eph receptor B1	Rattus norvegicus	59-62
22634758-10	2012	Furthermore, ROS produced after injury-induced p38MAPK and ERK activation in microglia, and mediated mechanical allodynia and thermal hyperalgesia, which were inhibited by AP or a ROS scavenger.	ros	180-183	Eph receptor B1	Rattus norvegicus	59-62
22763488-3	2012	Thus, the roles of SOD3 as an anti-oxidative enzyme in ROS-mediated lung inflammation and vascular disease such as ischemia and atherosclerosis, and its mechanism have been extensively studied.	ros	55-58	superoxide dismutase 3	Homo sapiens	19-23
22634137-6	2012	Analogous to wildtype-mice, estrogen-deficient OVX ApoE(-/-)-mice had low vascular PPARgamma-expression associated with ROS generation, endothelial dysfunction and atherogenesis.	ros	120-123	apolipoprotein E	Mus musculus	51-55
22513871-10	2012	Finally, we demonstrated Fus1-dependent basal and asbestos-induced changes in major mitochondrial parameters (ROS production, mitochondrial potential and UCP2 expression) in Fus1(-/-) immune cells and in Fus1-depleted cancer cells, thus supporting our hypothesis that Fus1 establishes its immune- and tumour-suppressive activities via regulation of mitochondrial homeostasis.	ros	110-113	tumor suppressor 2, mitochondrial calcium regulator	Mus musculus	25-29
22552773-0	2012	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	ros	44-47	nuclear factor, erythroid derived 2, like 2	Mus musculus	48-52
22227460-6	2012	These effects are mediated through c-Src- and EGFR-mediated downstream signaling pathways, including MAPK and PI3K/Akt pathways, eNOS uncoupling, and NOX/ROS system activation.	ros	154-157	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	35-40
22227460-6	2012	These effects are mediated through c-Src- and EGFR-mediated downstream signaling pathways, including MAPK and PI3K/Akt pathways, eNOS uncoupling, and NOX/ROS system activation.	ros	154-157	epidermal growth factor receptor	Homo sapiens	46-50
22827889-0	2012	Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model.	ros	45-48	ataxin 7	Homo sapiens	111-140
22827889-0	2012	Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model.	ros	45-48	ataxin 7	Homo sapiens	142-146
22827889-0	2012	Expanded ataxin-7 cause toxicity by inducing ROS production from NADPH oxidase complexes in a stable inducible Spinocerebellar ataxia type 7 (SCA7) model.	ros	45-48	ataxin 7	Homo sapiens	9-17
22848872-8	2012	Consistently, cells with mutant DFNA5 displayed significantly increased levels of ROS and signs of programmed cell death.	ros	82-85	gasdermin E	Homo sapiens	32-37
22827889-4	2012	RESULTS: In this study we show that expression of polyQ expanded ATXN7 in a novel stable inducible cell model first results in a concomitant increase in ROS levels and aggregation of the disease protein and later cellular toxicity.	ros	153-156	ataxin 7	Homo sapiens	65-70
22827889-5	2012	The increase in ROS could be completely prevented by inhibition of NADPH oxidase (NOX) complexes suggesting that ATXN7 directly or indirectly causes oxidative stress by increasing superoxide anion production from these complexes.	ros	16-19	ataxin 7	Homo sapiens	113-118
22507881-0	2012	DEP induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression.	ros	17-20	vascular endothelial growth factor A	Homo sapiens	66-72
22639047-7	2012	PKCalpha reversed doxorubicin-induced apoptosis through the scavenging of ROS as well as inhibition of PARP cleavage.	ros	74-77	protein kinase C alpha	Homo sapiens	0-8
22684029-1	2012	AIM: To investigate the mechanisms underlying the biphasic redox regulation of hypoxia-inducible factor-1 (HIF-1) transcriptional activity under different levels of oxidative stress caused by reactive oxidative species (ROS).	ros	220-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	79-105
22684029-1	2012	AIM: To investigate the mechanisms underlying the biphasic redox regulation of hypoxia-inducible factor-1 (HIF-1) transcriptional activity under different levels of oxidative stress caused by reactive oxidative species (ROS).	ros	220-223	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-112
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	ros	4-7	hypoxia inducible factor 1 subunit alpha	Homo sapiens	193-198
22684029-10	2012	CONCLUSION: The shift of HIF-1 transactivation by ROS is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.	ros	50-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	25-30
22618235-7	2012	The general patterns of FKBP12 and FKBP12.6 mRNA expression showed upregulation after hypoxia, downregulation after ischemia and normalization after reperfusion, which was partially attenuated if ROS was added during HEDA.	ros	196-199	FKBP prolyl isomerase 1B	Homo sapiens	35-43
22248368-4	2012	Neutralization of IL-13 and IL-4 protected hippocampal neurons in vivo against neurotoxicity by inhibiting activation of microglial NADPH oxidase and iNOS, resulting in attenuation of ROS generation and oxidative damage of protein, lipid and DNA.	ros	184-187	interleukin 13	Rattus norvegicus	18-23
22366763-6	2012	Subsequent analysis of the Nrf2-dependent transcription and translation showed that the aged mice (&gt;24months) had a significant increase in ROS along with a decrease in glutathione (GSH) levels and impaired antioxidants in Nrf2-/- when compared to WT SM.	ros	143-146	nuclear factor, erythroid derived 2, like 2	Mus musculus	27-31
22518836-5	2012	Isolated muscle fibers from the MCK-betaAPP mice also exhibited a reduction in cytoplasmic pH, an increased rate of ROS production, and a partially depolarized plasmalemma.	ros	116-119	creatine kinase, muscle	Mus musculus	32-35
22366763-7	2012	Further, disruption of Nrf2 appears to induce oxidative stress (increased ROS, HNE-positive proteins), ubiquitination and pro-apoptotic signals in the aged SM of Nrf2-/- mice.	ros	74-77	nuclear factor, erythroid derived 2, like 2	Mus musculus	23-27
22366763-10	2012	Thus, Nrf2 signaling might be a potential therapeutic target to protect the SM from age-dependent accumulation of ROS by rescuing redox homeostasis to prevent age-related muscle disorders such as sarcopenia and myopathy.	ros	114-117	nuclear factor, erythroid derived 2, like 2	Mus musculus	6-10
22652788-2	2012	Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells.	ros	211-214	nitric oxide synthase 2	Homo sapiens	289-320
22652788-2	2012	Recent evidence show that flavonoids possess several anti-inflammatory activities due to their ability to scavenge reactive oxygen and nitrogen species (ROS and RNS), to inhibit the pro-inflammatory activity of ROS-generating enzymes including cyclooxygenase (COX), lipoxygenase (LOX) and inducible nitric oxide synthase (iNOS) and to modulate different intracellular signaling pathways from NF-kB to mitogen-activated protein kinases (MAPKs) through perturbation of redox-sensible networks in immune cells.	ros	211-214	nitric oxide synthase 2	Homo sapiens	322-326
22472731-8	2012	Further studies demonstrated that ROS generation was involved in JNK activation, and Bcl-2 family anti-apoptotic proteins Mcl-1 and Bcl-xl were downstream targets of JNK to mediate apoptosis.	ros	34-37	mitogen-activated protein kinase 8	Homo sapiens	65-68
21882190-9	2012	HG promoted phosphorylation of ERK1/2, JNK and p38 MAP kinases, which was abrogated by an ROS inhibitor.	ros	90-93	mitogen-activated protein kinase 3	Homo sapiens	31-37
21882190-9	2012	HG promoted phosphorylation of ERK1/2, JNK and p38 MAP kinases, which was abrogated by an ROS inhibitor.	ros	90-93	mitogen-activated protein kinase 8	Homo sapiens	39-42
21882190-9	2012	HG promoted phosphorylation of ERK1/2, JNK and p38 MAP kinases, which was abrogated by an ROS inhibitor.	ros	90-93	mitogen-activated protein kinase 1	Homo sapiens	47-50
24278597-9	2012	While PCB-4 induced translocation of PKC-alpha and -epsilon was inhibited by ROS inhibitor, the pattern of translocation was not affected in presence of AhR inhibitor.	ros	77-80	pyruvate carboxylase	Homo sapiens	6-9
24278597-9	2012	While PCB-4 induced translocation of PKC-alpha and -epsilon was inhibited by ROS inhibitor, the pattern of translocation was not affected in presence of AhR inhibitor.	ros	77-80	protein kinase C alpha	Homo sapiens	37-59
22528395-6	2012	In addition, the knockdown of FABP3 also led to excess intracellular ROS production.	ros	69-72	fatty acid binding protein 3	Homo sapiens	30-35
21308489-8	2012	The present study indicates that p53 null osteosarcoma MG63 cells are susceptible to the ATO; the inhibition of catalase and the resulted intracellular ROS accumulation are an important molecular mechanism under which ATO induces apoptosis of p53-deficient osteosarcoma cells.	ros	152-155	tumor protein p53	Homo sapiens	33-36
21308489-8	2012	The present study indicates that p53 null osteosarcoma MG63 cells are susceptible to the ATO; the inhibition of catalase and the resulted intracellular ROS accumulation are an important molecular mechanism under which ATO induces apoptosis of p53-deficient osteosarcoma cells.	ros	152-155	catalase	Homo sapiens	112-120
21308489-8	2012	The present study indicates that p53 null osteosarcoma MG63 cells are susceptible to the ATO; the inhibition of catalase and the resulted intracellular ROS accumulation are an important molecular mechanism under which ATO induces apoptosis of p53-deficient osteosarcoma cells.	ros	152-155	tumor protein p53	Homo sapiens	243-246
22739161-6	2012	The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis.	ros	182-185	caspase 3	Homo sapiens	98-107
22472731-8	2012	Further studies demonstrated that ROS generation was involved in JNK activation, and Bcl-2 family anti-apoptotic proteins Mcl-1 and Bcl-xl were downstream targets of JNK to mediate apoptosis.	ros	34-37	mitogen-activated protein kinase 8	Homo sapiens	166-169
22739161-6	2012	The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis.	ros	182-185	mitogen-activated protein kinase 14	Homo sapiens	127-130
22739161-6	2012	The positive cell number of activated caspase 3, caspase 8, caspase 9 and the levels of activated caspase 3, caspase 9, p-JNK, P38 increased after Jurkat cells were treated with GA. ROS, CaMKII, caspase 3, caspase 9, MAPKK, JNK1/2 and P38 inhibitors had some significant effect on GA-induced apoptosis.	ros	182-185	caspase 3	Homo sapiens	98-107
22342995-2	2012	We previously demonstrated that gastrointestinal-derived tumor histotypes are resistant to ROS-based treatments by means of the redox activation of Nrf2, but highly sensitive to disulfide stressors triggering apoptosis via the redox induction of Trx1/p38(MAPK)/p53 signaling pathway.	ros	91-94	NFE2 like bZIP transcription factor 2	Homo sapiens	148-152
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	0-3	caspase 3	Homo sapiens	80-89
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	202-205
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	202-205
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	107-110	mitogen-activated protein kinase 14	Homo sapiens	31-34
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	107-110	caspase 3	Homo sapiens	80-89
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	107-110	mitogen-activated protein kinase 14	Homo sapiens	31-34
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	107-110	caspase 3	Homo sapiens	80-89
22739161-8	2012	It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway.	ros	102-105	mitogen-activated protein kinase 14	Homo sapiens	123-126
22387047-8	2012	Moreover, scavenging ROS induced by STAT3 inhibition also diminished antitumor activity of STAT3 inhibition.	ros	21-24	signal transducer and activator of transcription 3	Homo sapiens	36-41
22387047-6	2012	Blocking ROS generation with the antioxidant NDGA dramatically abolished NSC-743380-induced growth suppression and apoptosis, but had minimal effect on NSC-743380-induced STAT3 inhibition, suggesting that STAT3 inhibition is not caused by ROS production.	ros	9-12	signal transducer and activator of transcription 3	Homo sapiens	205-210
22273805-7	2012	These effects were observed in association with the loss of mitotic and metastatic potential of MCF-7 cells which was abolished in the presence of catalase (ROS scavenger) or 3MA (autophagic inhibitor).	ros	157-160	catalase	Homo sapiens	147-155
22387047-7	2012	Interestingly, knockdown of STAT3 with use of shSTAT3 induced ROS generation and suppressed tumor cell growth.	ros	62-65	signal transducer and activator of transcription 3	Homo sapiens	28-33
22387047-8	2012	Moreover, scavenging ROS induced by STAT3 inhibition also diminished antitumor activity of STAT3 inhibition.	ros	21-24	signal transducer and activator of transcription 3	Homo sapiens	91-96
22387047-10	2012	Our results indicate that NSC-743380 is a potent anticancer agent for lung cancer and that its apoptotic effects in lung cancer cells are mediated by induction of ROS through STAT3 inhibition.	ros	163-166	signal transducer and activator of transcription 3	Homo sapiens	175-180
22498476-7	2012	Asthma is associated with a cytokine milieu [e.g., interleukin (IL)-13] that promotes transforming growth factor-beta1 (TGFbeta1) affiliated airway remodeling, and agonistic relationships existed among these cytokines and ROS.	ros	222-225	transforming growth factor beta 1	Homo sapiens	86-118
22508836-5	2012	These cellular responses delay apoptotic cell death by inducing the IRE1alpha-XBP-1 pathway in conjunction with ROS-mediated mTOR inhibition.	ros	112-115	mechanistic target of rapamycin kinase	Homo sapiens	125-129
22095288-0	2012	PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk.	ros	39-42	death associated protein kinase 1	Homo sapiens	75-79
22415872-7	2012	This ROS/Src/Erk pathway mechanism appeared to be the same route by which DM induced LPA resistance of retinal neovessels.	ros	5-8	mitogen-activated protein kinase 1	Mus musculus	13-16
22330066-8	2012	EGCG attenuated dexamethasone and TNF-alpha promoted ROS generation and increased glucose uptake ability.	ros	53-56	tumor necrosis factor	Rattus norvegicus	34-43
22493269-11	2012	Taken together, these studies reveal that ROS stimulates Galpha12 to activate injury pathways and identifies a therapeutic target for ameliorating ROS mediated injury.	ros	42-45	guanine nucleotide binding protein, alpha 12	Mus musculus	57-65
22493269-11	2012	Taken together, these studies reveal that ROS stimulates Galpha12 to activate injury pathways and identifies a therapeutic target for ameliorating ROS mediated injury.	ros	147-150	guanine nucleotide binding protein, alpha 12	Mus musculus	57-65
22284365-5	2012	First, ROS induced by TNF-alpha was measured by staining with CM-H(2)DCFDA.	ros	7-10	tumor necrosis factor	Homo sapiens	22-31
22285910-0	2012	Vinca alkaloids cause aberrant ROS-mediated JNK activation, Mcl-1 downregulation, DNA damage, mitochondrial dysfunction, and apoptosis in lung adenocarcinoma cells.	ros	31-34	mitogen-activated protein kinase 8	Homo sapiens	44-47
22285910-6	2012	Vinca alkaloids and nocodazole caused glutathione/reactive oxygen species (ROS) imbalance, and inhibiting ROS prevented prolonged JNK activation, decreased Mcl-1 levels, MTP loss, and apoptosis.	ros	106-109	mitogen-activated protein kinase 8	Homo sapiens	130-133
22285910-9	2012	These results demonstrate an essential role of ROS in vinca alkaloid-induced aberrant JNK-mediated Mcl-1 downregulation and DNA damage followed by mitochondrial dysfunction-related apoptosis but not mitotic arrest.	ros	47-50	mitogen-activated protein kinase 8	Homo sapiens	86-89
22269942-0	2012	Live-attenuated measles virus vaccine confers cell contact loss and apoptosis of ovarian cancer cells via ROS-induced silencing of E-cadherin by methylation.	ros	106-109	cadherin 1	Homo sapiens	131-141
22310237-4	2012	It was also found that 69.6% of LoVo cells and 90.6% of MCF-7 cells entered the early phase of apoptosis when treated with 100 muM QS for 48 h. Furthermore, we firstly found the generation of ROS is a critical mediator in QS-induced cell growth inhibition.	ros	192-195	latexin	Homo sapiens	127-130
22295890-3	2012	Mesenteric smooth muscle cells (MesSMC) from spontaneously hypertensive rats (SHR) were incubated with AngII (0.1 mumol/L) alone, or with the mixture of low concentrations of Q and C. AngII-increased ROS production was reduced by the mixture of separately ineffective low concentration of Q (15 mumol/L) plus C (20 mumol/L).	ros	200-203	angiotensinogen	Rattus norvegicus	184-189
22498476-7	2012	Asthma is associated with a cytokine milieu [e.g., interleukin (IL)-13] that promotes transforming growth factor-beta1 (TGFbeta1) affiliated airway remodeling, and agonistic relationships existed among these cytokines and ROS.	ros	222-225	transforming growth factor beta 1	Homo sapiens	120-128
22202674-6	2012	Lastly, either NAC treatment (EC(50) 4 mM) or either GCLC or GCLM overexpression exhibited increased cytotoxicity and the susceptibility to the more reducing milieu was achieved at decreased levels of ROS.	ros	201-204	glutamate-cysteine ligase, catalytic subunit	Rattus norvegicus	53-57
22052190-9	2012	These results suggest that PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging.	ros	106-109	tumor protein p53	Homo sapiens	119-122
22351695-9	2012	Gene expression profiling revealed two main mechanisms of action: PI3K/AKT inhibition and induction of ROS that resulted in an oxidative stress response through activating protein 1 (AP-1), c-jun-NH(2)-terminal kinase, and ATF3 culminating in the upregulation of NOXA.	ros	103-106	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	263-267
22351695-10	2012	ROS scavengers and shRNA mediated knockdown of ATF3- and NOXA-protected cells from drug-induced apoptosis.	ros	0-3	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	57-61
22202674-6	2012	Lastly, either NAC treatment (EC(50) 4 mM) or either GCLC or GCLM overexpression exhibited increased cytotoxicity and the susceptibility to the more reducing milieu was achieved at decreased levels of ROS.	ros	201-204	glutamate cysteine ligase, modifier subunit	Rattus norvegicus	61-65
22279179-5	2012	We observed that CuNG-induced ROS generation triggers activation of two MAPKs, i.e., p38MAPK and ERK1/2, and also causes up-regulation of intracellular glutathione.	ros	30-33	mitogen-activated protein kinase 3	Homo sapiens	97-103
22044025-6	2012	The rate of CaM degradation was found to be dependent on cellular Ca(2+) and ROS levels.	ros	77-80	calmodulin 1	Homo sapiens	12-15
22288910-5	2012	This 2-ABP-induced COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI.	ros	54-57	prostaglandin-endoperoxide synthase 2	Homo sapiens	19-24
22288910-12	2012	Taken together, these results demonstrate that 2-ABP induces the carcinogenic factor COX-2 and that this induction is mediated through NADPH oxidase-derived ROS-dependent JNK/ERK-AP-1 pathways.	ros	157-160	prostaglandin-endoperoxide synthase 2	Homo sapiens	85-90
22288910-12	2012	Taken together, these results demonstrate that 2-ABP induces the carcinogenic factor COX-2 and that this induction is mediated through NADPH oxidase-derived ROS-dependent JNK/ERK-AP-1 pathways.	ros	157-160	mitogen-activated protein kinase 8	Homo sapiens	171-174
22288910-12	2012	Taken together, these results demonstrate that 2-ABP induces the carcinogenic factor COX-2 and that this induction is mediated through NADPH oxidase-derived ROS-dependent JNK/ERK-AP-1 pathways.	ros	157-160	mitogen-activated protein kinase 1	Homo sapiens	175-178
22288910-0	2012	Cyclooxygenase-2 expression is up-regulated by 2-aminobiphenyl in a ROS and MAPK-dependent signaling pathway in a bladder cancer cell line.	ros	68-71	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	188-191	mitogen-activated protein kinase 1	Mus musculus	64-67
22313584-7	2012	UCP2 was increased by CLA mixture and c9, t11 CLA for attenuating production of ROS.	ros	80-83	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	0-4
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	60-63	mitogen-activated protein kinase 1	Mus musculus	211-214
22230328-3	2012	However, using whole cell binding assays with [(3)H]-alendronate, herein we demonstrated the presence of saturable, specific and high affinity binding sites in the Cx43-expressing ROS 17/2.8 osteoblastic cells, authentic osteoblasts and MLO-Y4 cells expressing Cx43 or not, as well as in HeLa cells lacking Cx43 expression and ROS 17/2.8 cells pretreated with agents that disassemble Cx channels.	ros	180-183	gap junction protein, alpha 1	Rattus norvegicus	164-168
22230328-3	2012	However, using whole cell binding assays with [(3)H]-alendronate, herein we demonstrated the presence of saturable, specific and high affinity binding sites in the Cx43-expressing ROS 17/2.8 osteoblastic cells, authentic osteoblasts and MLO-Y4 cells expressing Cx43 or not, as well as in HeLa cells lacking Cx43 expression and ROS 17/2.8 cells pretreated with agents that disassemble Cx channels.	ros	327-330	gap junction protein, alpha 1	Rattus norvegicus	164-168
22120492-5	2012	Then, we found that C3G attenuated TNF-alpha-induced ROS over generation by Dihydroethidium staining.	ros	53-56	tumor necrosis factor	Mus musculus	35-44
22120492-9	2012	Administration of the ROS scavenger catalase (2,000 U/ml) remarkably inhibited TNF-alpha-induced cell proliferation and STAT3 activation.	ros	22-25	tumor necrosis factor	Mus musculus	79-88
22120492-9	2012	Administration of the ROS scavenger catalase (2,000 U/ml) remarkably inhibited TNF-alpha-induced cell proliferation and STAT3 activation.	ros	22-25	signal transducer and activator of transcription 3	Mus musculus	120-125
22120492-10	2012	These data suggest that C3G exerts its antiproliferative effect on TNF-alpha-induced VSMCs proliferation through inhibiting STAT3 activation by attenuating NoxA1-derived ROS over production.	ros	170-173	tumor necrosis factor	Mus musculus	67-76
21736589-9	2012	A SAG21/AtLEA5-YFP fusion was localized to mitochondria, raising the intriguing possibility that SAG21 interacts with proteins involved in mitochondrial ROS signalling, which in turn, impacts on root development and pathogen responses.	ros	153-156	senescence-associated gene 21	Arabidopsis thaliana	8-14
22095949-4	2012	Persistent activation of the Ang II receptor stimulated ROS-dependent phosphorylation of Src, leading to sustained EGFR-dependent signaling for TGFbeta expression.	ros	56-59	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	29-35
22101522-8	2012	Removal of the conserved PKC site Ser(1503) or exposure to the NADPH oxidase inhibitor apocynin eliminated the PKC-mediated effect to alter channel trafficking, indicating that both channel phosphorylation and ROS were required.	ros	210-213	proline rich transmembrane protein 2	Homo sapiens	111-114
22036979-2	2012	Since over production of ROS and proinflammatory cytokine are often act as the triggers for the promotion stage of carcinogenesis by transcriptional up-regulation of nuclear factor-kappaB (NF-kappaB) and cycloxygenage-2 (COX-2).	ros	25-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	189-198
22318358-3	2012	THP-1 cells exposed to a range of 3BP concentrations in combination with DCA showed increase of polarization, slight ROS increase, and weakened nuclear integrity.	ros	117-120	GLI family zinc finger 2	Homo sapiens	0-5
21902595-5	2012	Moreover, regulation of Oct4 by Ago2 directly controls the stem cell plasticity-determining signal mediators JAK2/STAT3 and Wnt5A/beta-catenin and positively regulates cell proliferation and differentiation via blockage of ROS generation and P38/JNK inactivation.	ros	223-226	argonaute RISC catalytic component 2	Homo sapiens	32-36
22251375-9	2012	CONCLUSION: From these results, we conclude that JEV activates the ROS/c-Src/PDGFR/PI3K/Akt/MAPKs pathway, which in turn triggers AP-1 activation and ultimately induces MMP-9 expression in RBA-1 cells.	ros	67-70	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	71-76
22251375-9	2012	CONCLUSION: From these results, we conclude that JEV activates the ROS/c-Src/PDGFR/PI3K/Akt/MAPKs pathway, which in turn triggers AP-1 activation and ultimately induces MMP-9 expression in RBA-1 cells.	ros	67-70	platelet derived growth factor receptor beta	Homo sapiens	77-82
22251375-9	2012	CONCLUSION: From these results, we conclude that JEV activates the ROS/c-Src/PDGFR/PI3K/Akt/MAPKs pathway, which in turn triggers AP-1 activation and ultimately induces MMP-9 expression in RBA-1 cells.	ros	67-70	AKT serine/threonine kinase 1	Homo sapiens	88-91
21900685-11	2012	These results indicated that increased intracellular ROS impaired luteal formation and progesterone production in the mutant females, thus suggesting that SOD1 plays a crucial role in both the luteal function and the maintenance of fertility in female mice.	ros	53-56	superoxide dismutase 1, soluble	Mus musculus	155-159
21902595-5	2012	Moreover, regulation of Oct4 by Ago2 directly controls the stem cell plasticity-determining signal mediators JAK2/STAT3 and Wnt5A/beta-catenin and positively regulates cell proliferation and differentiation via blockage of ROS generation and P38/JNK inactivation.	ros	223-226	signal transducer and activator of transcription 3	Homo sapiens	114-119
21902595-5	2012	Moreover, regulation of Oct4 by Ago2 directly controls the stem cell plasticity-determining signal mediators JAK2/STAT3 and Wnt5A/beta-catenin and positively regulates cell proliferation and differentiation via blockage of ROS generation and P38/JNK inactivation.	ros	223-226	Wnt family member 5A	Homo sapiens	124-129
21902595-8	2012	INNOVATION AND CONCLUSION: This study reveals that nuclear Ago2 globally controls stem cell self-renewal and differentiation through direct regulation of stemness genes and important signal mediator activation following inactivation of ROS/P38/JNK and activation of the JAK/STAT3 and Wnt/ beta-catenin signal pathways.	ros	236-239	argonaute RISC catalytic component 2	Homo sapiens	59-63
21902595-8	2012	INNOVATION AND CONCLUSION: This study reveals that nuclear Ago2 globally controls stem cell self-renewal and differentiation through direct regulation of stemness genes and important signal mediator activation following inactivation of ROS/P38/JNK and activation of the JAK/STAT3 and Wnt/ beta-catenin signal pathways.	ros	236-239	signal transducer and activator of transcription 3	Homo sapiens	274-279
22399425-6	2012	Additionally the generation of ROS from mitochondria and other cellular sources may interfere in insulin signaling in muscle, contributing to insulin resistance.	ros	31-34	insulin	Homo sapiens	97-104
22399425-6	2012	Additionally the generation of ROS from mitochondria and other cellular sources may interfere in insulin signaling in muscle, contributing to insulin resistance.	ros	31-34	insulin	Homo sapiens	142-149
22399425-7	2012	Reduced mitochondrial oxidative capacity coupled with increased ROS generation underlies the accumulation of intramuscular fat, insulin resistance and muscle dysfunction in aging.	ros	64-67	insulin	Homo sapiens	128-135
23339309-6	2012	We focus on (i) the coordination chemistry of Cu and heme to Abeta; (ii) the role of the corresponding Abeta adducts in the (catalytic) production of ROS/RNS; (iii) the subsequent degradation of Abeta by these reactive species and (iv) the use of antioxidants, in particular metal sequestering compounds and direct antioxidants like polyphenols as a therapeutic strategies.	ros	150-153	amyloid beta precursor protein	Homo sapiens	103-108
22217266-8	2012	The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by Ang II, indicating that Ang II uses ROS as a second messenger to regulate STAT1 activity.	ros	44-47	angiotensinogen	Homo sapiens	89-95
22217266-8	2012	The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by Ang II, indicating that Ang II uses ROS as a second messenger to regulate STAT1 activity.	ros	44-47	angiotensinogen	Homo sapiens	113-119
22217266-8	2012	The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by Ang II, indicating that Ang II uses ROS as a second messenger to regulate STAT1 activity.	ros	125-128	angiotensinogen	Homo sapiens	89-95
22217266-8	2012	The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by Ang II, indicating that Ang II uses ROS as a second messenger to regulate STAT1 activity.	ros	125-128	angiotensinogen	Homo sapiens	113-119
23339309-6	2012	We focus on (i) the coordination chemistry of Cu and heme to Abeta; (ii) the role of the corresponding Abeta adducts in the (catalytic) production of ROS/RNS; (iii) the subsequent degradation of Abeta by these reactive species and (iv) the use of antioxidants, in particular metal sequestering compounds and direct antioxidants like polyphenols as a therapeutic strategies.	ros	150-153	amyloid beta precursor protein	Homo sapiens	103-108
22003059-0	2012	Membrane depolarization is the trigger for PI3K/Akt activation and leads to the generation of ROS.	ros	94-97	thymoma viral proto-oncogene 1	Mus musculus	48-51
22037022-0	2012	Targeting the mitochondrial pathway to induce apoptosis/necrosis through ROS by a newly developed Schiff"s base to overcome MDR in cancer.	ros	73-76	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	124-127
22975630-5	2012	It has been reported that ROS-induced oxidative stress enhanced ERalpha expression.	ros	26-29	estrogen receptor 1	Homo sapiens	64-71
22508049-6	2012	It up-regulates ROS-GC1 activity with a K(1/2) for Ca(2+) greater than 500 nM and modulates the transmission of neural signals to cone ON-bipolar cells.	ros	16-19	guanylate cyclase 2e	Mus musculus	20-23
22283774-4	2012	Activation of the classic RAS, ACE/Ang II/AT1R, has been strictly related to down regulation of pro-survival genes (Nampt and Sirt3), increase in ROS production and pro-inflammatory cytokines and chemokines release, leading to cell senescence, inflammation and development of autoimmune dysfunctions.	ros	146-149	angiotensin I converting enzyme	Homo sapiens	31-34
22124463-0	2012	Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.	ros	79-82	sirtuin 1	Rattus norvegicus	0-9
23339309-0	2012	Copper and heme-mediated Abeta toxicity: redox chemistry, Abeta oxidations and anti-ROS compounds.	ros	84-87	amyloid beta precursor protein	Homo sapiens	25-30
22007260-4	2012	Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-kappaB- and p53-signaling pathways in both cell types.	ros	119-122	tumor protein p53	Homo sapiens	161-164
22577256-2	2012	Out of several ROS-generating systems, the inflammatory enzymes nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and inducible nitric oxide synthase (iNOS) were believed to play major roles.	ros	15-18	nitric oxide synthase 2	Homo sapiens	161-165
21753779-6	2012	Tumor necrosis factor-alpha- and benzo(a)pyrene (BaP)-induced reactive oxidative species (ROS) and IL-8 production were effectively inhibited by KCZ.	ros	90-93	tumor necrosis factor	Homo sapiens	0-27
21753779-7	2012	Knockdown of either AhR or Nrf2 abolished the inhibitory capacity of KCZ on ROS and IL-8 production.	ros	76-79	NFE2 like bZIP transcription factor 2	Homo sapiens	27-31
22544998-3	2012	This oxidative stress response occurs in microglia through the activation of the ERK signaling pathway by proinflammatory stimuli, leading to the phosphorylation and translocation of the p47(phox) and p67(phox) cytosolic subunits, the activation of membrane-bound PHOX, and the production of ROS.	ros	292-295	mitogen-activated protein kinase 1	Homo sapiens	81-84
22222493-8	2012	RESULTS: VEGF activates downstream signaling molecules, including Ca(2+)/CAMKK, Rac1/NOX, ROS/ERK, Ezrin/Calpain/PI3K/Akt, PLCgamma/PKC and Src/HSP90.	ros	90-93	vascular endothelial growth factor A	Homo sapiens	9-13
22919281-3	2012	More recently, several oncogenes have been shown to activate Nrf2 signaling as the main prosurvival pathway mediating ROS detoxification, senescence evasion, and neoplastic transformation.	ros	118-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
21954286-13	2012	The presence of p67(phox)-citrine was correlated with the duration of phagosomal ROS production in different opsonization conditions.	ros	81-84	CD33 molecule	Homo sapiens	16-19
21954286-14	2012	These data support the critical role of p67(phox) for ROS production on the level of individual phagosomes.	ros	54-57	CD33 molecule	Homo sapiens	40-43
22544998-3	2012	This oxidative stress response occurs in microglia through the activation of the ERK signaling pathway by proinflammatory stimuli, leading to the phosphorylation and translocation of the p47(phox) and p67(phox) cytosolic subunits, the activation of membrane-bound PHOX, and the production of ROS.	ros	292-295	CD33 molecule	Homo sapiens	201-204
22577256-3	2012	Mounting evidence suggests that activation of NADPH oxidase and the expression of iNOS are directly linked to the generation of highly reactive ROS which affects various cellular components and preferentially damage midbrain dopaminergic neurons in PD.	ros	144-147	nitric oxide synthase 2	Homo sapiens	82-86
21947658-0	2012	Repeated short-term stress synergizes the ROS signalling through up regulation of NFkB and iNOS expression induced due to combined exposure of trichloroethylene and UVB rays.	ros	42-45	nitric oxide synthase 2, inducible	Mus musculus	91-95
22829775-3	2012	Using a panel of GFP-fused stress response genes, we identified the suites of cytoprotective pathways upregulated by 160 gene inactivations known to increase Caenorhabditis elegans longevity, including the mitochondrial UPR (hsp-6, hsp-60), the ER UPR (hsp-4), ROS response (sod-3, gst-4), and xenobiotic detoxification (gst-4).	ros	261-264	Glutathione S-transferase 4	Caenorhabditis elegans	282-287
23087143-10	2012	Meanwhile, EGCG reduced Ang II- and IL-6-stimulated generation of ROS in macrophages.	ros	66-69	angiotensinogen	Homo sapiens	24-30
23087143-10	2012	Meanwhile, EGCG reduced Ang II- and IL-6-stimulated generation of ROS in macrophages.	ros	66-69	interleukin 6	Homo sapiens	36-40
23087143-11	2012	CONCLUSION: EGCG is able to inhibit Ang II- and IL-6-stimulated CRP expression in macrophages to produce an anti-inflammation by interfering with ROS generation.	ros	146-149	angiotensinogen	Homo sapiens	36-42
23087143-11	2012	CONCLUSION: EGCG is able to inhibit Ang II- and IL-6-stimulated CRP expression in macrophages to produce an anti-inflammation by interfering with ROS generation.	ros	146-149	interleukin 6	Homo sapiens	48-52
23087143-11	2012	CONCLUSION: EGCG is able to inhibit Ang II- and IL-6-stimulated CRP expression in macrophages to produce an anti-inflammation by interfering with ROS generation.	ros	146-149	C-reactive protein	Homo sapiens	64-67
21984036-10	2012	Our results show that PMA can induce MUC5AC expression by activation of the Duox1-ROS-TACE-TGF-alpha-EGFR signaling pathway.	ros	82-85	epidermal growth factor receptor	Homo sapiens	101-105
22802906-2	2012	Mechanisms involved include an autoamplification circuit linking ROS, Ras and ERK 1-2 which in turn amplifies and maintains the autocrine loop made up by cytokines, growth factors and their cognate receptors.This review summarizes the recent progress on the role of oxidative stress in the pathophysiology of scleroderma and disorders characterised by organ fibrosis.	ros	65-68	mitogen-activated protein kinase 3	Homo sapiens	78-85
22829775-3	2012	Using a panel of GFP-fused stress response genes, we identified the suites of cytoprotective pathways upregulated by 160 gene inactivations known to increase Caenorhabditis elegans longevity, including the mitochondrial UPR (hsp-6, hsp-60), the ER UPR (hsp-4), ROS response (sod-3, gst-4), and xenobiotic detoxification (gst-4).	ros	261-264	Glutathione S-transferase 4	Caenorhabditis elegans	321-326
22848625-4	2012	In RCC4 cells, inhibition of mTOR with CCI-779 stimulates autophagy and eliminates RIP kinases (RIPKs) and this is blocked by autophagy inhibition, which induces RIPK- and ROS-dependent necroptosis in vitro and suppresses xenograft growth.	ros	172-175	mechanistic target of rapamycin kinase	Homo sapiens	29-33
23284736-9	2012	The present results show that this ancient herbal decoction benefits endothelial function through increased activity of Akt kinase and eNOS; this effect is causally via a rise of intracellular Ca(2+) and a reduction of ROS.	ros	219-222	AKT serine/threonine kinase 1	Homo sapiens	120-123
23284736-9	2012	The present results show that this ancient herbal decoction benefits endothelial function through increased activity of Akt kinase and eNOS; this effect is causally via a rise of intracellular Ca(2+) and a reduction of ROS.	ros	219-222	nitric oxide synthase 3	Homo sapiens	135-139
23029187-9	2012	These observations suggest that enhancing Nrf2 function and endogenous cytoprotective mechanisms by MET, may combat age-induced ROS/RNS and protect the myocardium from oxidative stress diseases.	ros	128-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	42-46
22880003-10	2012	A correlation was found between NRT2.6 expression and ROS species accumulation in response to infection by E. amylovora and treatment with the redox-active herbicide methyl viologen, suggesting a probable link between NRT2.6 activity and the production of ROS in response to biotic and abiotic stress.	ros	54-57	nitrate transporter 2:1	Arabidopsis thaliana	32-36
22880003-10	2012	A correlation was found between NRT2.6 expression and ROS species accumulation in response to infection by E. amylovora and treatment with the redox-active herbicide methyl viologen, suggesting a probable link between NRT2.6 activity and the production of ROS in response to biotic and abiotic stress.	ros	54-57	nitrate transporter 2:1	Arabidopsis thaliana	218-222
22880003-10	2012	A correlation was found between NRT2.6 expression and ROS species accumulation in response to infection by E. amylovora and treatment with the redox-active herbicide methyl viologen, suggesting a probable link between NRT2.6 activity and the production of ROS in response to biotic and abiotic stress.	ros	256-259	nitrate transporter 2:1	Arabidopsis thaliana	32-36
22880003-10	2012	A correlation was found between NRT2.6 expression and ROS species accumulation in response to infection by E. amylovora and treatment with the redox-active herbicide methyl viologen, suggesting a probable link between NRT2.6 activity and the production of ROS in response to biotic and abiotic stress.	ros	256-259	nitrate transporter 2:1	Arabidopsis thaliana	218-222
22848625-6	2012	Thus, coordinate mTOR and autophagy inhibition leads to an imbalance between ROS production and defense, causing necroptosis that may enhance cancer treatment efficacy.	ros	77-80	mechanistic target of rapamycin kinase	Homo sapiens	17-21
22768036-6	2012	Low dose RES/CUR enhances the CC action through ROS mediated JNK/p38 as well as mitochondrial pathway in MCF-7 cells.	ros	48-51	mitogen-activated protein kinase 14	Homo sapiens	65-68
22916164-5	2012	Reducing PRDX4 expression significantly decreased GBM cell growth and radiation resistance in vitro with increased levels of ROS, DNA damage, and apoptosis.	ros	125-128	peroxiredoxin 4	Mus musculus	9-14
22815910-8	2012	During ICAM-1 activation of PKCalpha, the XO-generated ROS did not oxidize PKCalpha.	ros	55-58	protein kinase C alpha	Homo sapiens	28-36
22815910-11	2012	CONCLUSIONS: Crosslinking ICAM-1 stimulated XO/ROS which activated ERK1/2 that then activated PKCalpha.	ros	47-50	mitogen-activated protein kinase 3	Homo sapiens	67-73
22815910-11	2012	CONCLUSIONS: Crosslinking ICAM-1 stimulated XO/ROS which activated ERK1/2 that then activated PKCalpha.	ros	47-50	protein kinase C alpha	Homo sapiens	94-102
22768036-7	2012	However, RES/CUR sensitization enhanced apoptosis in p53 mutant MDA MB-231 cells without/with involvement of ROS mediated JNK/p38 adjunct to Caspase-9.	ros	109-112	mitogen-activated protein kinase 14	Homo sapiens	126-129
22701598-0	2012	The ROS scavenger, NAC, regulates hepatic Valpha14iNKT cells signaling during Fas mAb-dependent fulminant liver failure.	ros	4-7	T cell receptor alpha, variable 14	Mus musculus	42-50
22693564-10	2012	Importantly, our data point to a critical role for the mitochondria in regulating ROS generation in response to Ang II.	ros	82-85	angiotensinogen	Homo sapiens	112-118
22701598-4	2012	In summary, we propose a novel and previously unrecognized pro-inflammatory and pro-apoptotic role for endogenous ROS in stimulating Th1 signaling in Valpha14iNKT cells to promote the development of FLF.	ros	114-117	negative elongation factor complex member C/D, Th1l	Mus musculus	133-136
22701598-5	2012	Therefore, our study provides critical new insights into how NAC, a ROS scavenger, regulates Th1 signaling in intrahepatic Valpha14iNKT cells to impact inflammatory and pathological responses.	ros	68-71	negative elongation factor complex member C/D, Th1l	Mus musculus	93-96
22848731-8	2012	TSA activated a ROS triggered, p53 independent and caspase dependent mitochondria apoptotic cell death pathway that is characterized with increased ratio of Bax to Bcl-xl, mitochondrial membrane potential disruption, cytochrome c release, and subsequent caspase activation and PARP-1 cleavage.	ros	16-19	BCL2 associated X, apoptosis regulator	Homo sapiens	157-160
22701598-5	2012	Therefore, our study provides critical new insights into how NAC, a ROS scavenger, regulates Th1 signaling in intrahepatic Valpha14iNKT cells to impact inflammatory and pathological responses.	ros	68-71	T cell receptor alpha, variable 14	Mus musculus	123-131
22848731-8	2012	TSA activated a ROS triggered, p53 independent and caspase dependent mitochondria apoptotic cell death pathway that is characterized with increased ratio of Bax to Bcl-xl, mitochondrial membrane potential disruption, cytochrome c release, and subsequent caspase activation and PARP-1 cleavage.	ros	16-19	BCL2 like 1	Homo sapiens	164-170
22848731-8	2012	TSA activated a ROS triggered, p53 independent and caspase dependent mitochondria apoptotic cell death pathway that is characterized with increased ratio of Bax to Bcl-xl, mitochondrial membrane potential disruption, cytochrome c release, and subsequent caspase activation and PARP-1 cleavage.	ros	16-19	cytochrome c, somatic	Homo sapiens	217-229
22242180-9	2012	Thus this study suggests that ROS/RNS contributed to change of p53 tertiary structure and that unfolded p53 can be considered as an early marker of oxidative imbalance in these patients.	ros	30-33	tumor protein p53	Homo sapiens	63-66
22848731-8	2012	TSA activated a ROS triggered, p53 independent and caspase dependent mitochondria apoptotic cell death pathway that is characterized with increased ratio of Bax to Bcl-xl, mitochondrial membrane potential disruption, cytochrome c release, and subsequent caspase activation and PARP-1 cleavage.	ros	16-19	poly(ADP-ribose) polymerase 1	Homo sapiens	277-283
22355787-0	2012	Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.	ros	98-101	cyclin dependent kinase inhibitor 2A	Mus musculus	65-68
22355787-0	2012	Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.	ros	98-101	DNA methyltransferase (cytosine-5) 1	Mus musculus	106-111
22276192-8	2012	PPARgamma activation significantly attenuated thapsigargin-induced cell death, concomitant with an inhibition of caspase activation, a delay in DeltaPsim loss, and a reduction of superoxide/ROS generation in STHdh(Q111) cells.	ros	190-193	peroxisome proliferator activated receptor gamma	Homo sapiens	0-9
22276192-9	2012	Expression of mutant huntingtin in primary neurons induced superoxide/ROS, an effect that was significantly reduced by constitutively active PPARgamma.	ros	70-73	peroxisome proliferator activated receptor gamma	Homo sapiens	141-150
22039262-3	2011	Although the loss of Nrf2 leads to increased ROS in most tissues, basal ROS levels in Nrf2-deficient (Nrf2(-/-)) BM were not elevated compared with wild-type.	ros	45-48	nuclear factor, erythroid derived 2, like 2	Mus musculus	21-25
22039262-3	2011	Although the loss of Nrf2 leads to increased ROS in most tissues, basal ROS levels in Nrf2-deficient (Nrf2(-/-)) BM were not elevated compared with wild-type.	ros	72-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
22039262-3	2011	Although the loss of Nrf2 leads to increased ROS in most tissues, basal ROS levels in Nrf2-deficient (Nrf2(-/-)) BM were not elevated compared with wild-type.	ros	72-75	nuclear factor, erythroid derived 2, like 2	Mus musculus	86-90
21861192-7	2011	ROS inhibition prevented p73 and Noxa expression but not p53 and p21 expression, suggesting a role for Noxa in p53-independent apoptosis in melanoma cells.	ros	0-3	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	33-37
21792596-9	2011	ROS production correlates positively with BZLF-1, SOD, and CAT gene expressions (p &lt; 0.05; r = 0.913, r = 0.978, and r = 0.955, respectively).	ros	0-3	catalase	Homo sapiens	59-62
21890195-7	2011	Moreover, Oct4/SirT1 overexpression resulted in the demethylation of the Oct4 promoter and enhanced the expression of antioxidant enzymes, which was accompanied by a decrease in intracellular ROS production and hydrogen peroxide-induced oxidative stress.	ros	192-195	sirtuin 1	Rattus norvegicus	15-20
21861192-7	2011	ROS inhibition prevented p73 and Noxa expression but not p53 and p21 expression, suggesting a role for Noxa in p53-independent apoptosis in melanoma cells.	ros	0-3	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	103-107
21861192-7	2011	ROS inhibition prevented p73 and Noxa expression but not p53 and p21 expression, suggesting a role for Noxa in p53-independent apoptosis in melanoma cells.	ros	0-3	tumor protein p53	Homo sapiens	111-114
21859819-5	2011	At 3 weeks, Alk1(+/-) mice were indistinguishable from controls and were prevented from subsequently developing PH when treated with the anti-oxidant Tempol for 6 weeks, confirming a role for ROS in pathogenesis.	ros	192-195	activin A receptor, type II-like 1	Mus musculus	12-16
22041887-8	2011	In coculture, tamoxifen induces the upregulation of TIGAR (TP53-induced glycolysis and apoptosis regulator), a p53 regulated gene that simultaneously inhibits glycolysis, autophagy and apoptosis and reduces ROS generation, thereby promoting oxidative mitochondrial metabolism.	ros	207-210	tumor protein p53	Homo sapiens	111-114
21859819-8	2011	In contrast, NO production was reduced, while endothelial NO synthase (eNOS)-dependent ROS production was increased in adult Alk1(+/-) mice.	ros	87-90	activin A receptor, type II-like 1	Mus musculus	125-129
21859819-10	2011	CONCLUSION: The increased pulmonary vascular remodelling in Alk1(+/-) mice leads to signs of PH and is associated with eNOS-dependent ROS production, which is preventable by anti-oxidant treatment.	ros	134-137	activin A receptor, type II-like 1	Mus musculus	60-64
21982843-0	2011	Plumbagin and juglone induce caspase-3-dependent apoptosis involving the mitochondria through ROS generation in human peripheral blood lymphocytes.	ros	94-97	caspase 3	Homo sapiens	29-38
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	44-47	superoxide dismutase 1	Homo sapiens	192-212
22055193-7	2011	Lpin1 expression in response to nutritional stress is controlled through the ROS-ATM-p53 pathway and is conserved in human cells.	ros	77-80	tumor protein p53	Homo sapiens	85-88
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	44-47	superoxide dismutase 1	Homo sapiens	214-217
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	44-47	catalase	Homo sapiens	220-228
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	303-306	superoxide dismutase 1	Homo sapiens	192-212
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	303-306	catalase	Homo sapiens	220-228
21871559-6	2011	Insulin-tBH coadministration abrogated the low or high glucose requirement for promoter activation, suggesting possible ROS involvement.	ros	120-123	insulin	Homo sapiens	0-7
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	ros	81-84	TNF superfamily member 10	Homo sapiens	53-58
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	ros	81-84	BCL2 apoptosis regulator	Homo sapiens	157-162
21854768-9	2011	Taken together, our results demonstrated that acrolein enhances TRAIL-induced apoptosis in Caki cells through down-regulation of Bcl-2 and ROS dependent up-regulation of DR5.	ros	139-142	TNF superfamily member 10	Homo sapiens	64-69
21779911-6	2011	ROS scavenger NAC, caffeine and an ATM-specific inhibitor significantly reduced ARV S1133- and sigmaC-induced DNA breaks, DDIT-3 and GADD45alpha expression, H2AX phosphorylation, and apoptosis.	ros	0-3	ATM serine/threonine kinase	Gallus gallus	35-38
21722713-13	2011	Prior chronic exercise suppressed KA-induced hippocampal neuronal death in hippocampal CA3 region in restrained mice via declined ROS levels, which was lower MDA and nitrite levels, and activation of CREB, which was mediated by ERK1/2 and CaMKII, suggesting that chronic exercise exerts a protective effect on excitatory neurodegenerative disorders including epileptic seizure.	ros	130-133	carbonic anhydrase 3	Mus musculus	87-90
22005299-5	2011	In human platelets, aldose reductase synergistically modulated platelet response to both hyperglycemia and collagen exposure through a pathway involving ROS/PLCgamma2/PKC/p38alpha MAPK.	ros	153-156	aldo-keto reductase family 1 member B	Homo sapiens	20-36
21837363-12	2011	Taken together, these findings demonstrate that activation of Akt, followed by GSK3beta inhibition and Bcl-2, Bcl-XL up-regulation and decrease of ROS generation, along with a synergistic effect of Rb down-regulation may cause apoptosis resistance, contributing to the overall mechanism of nickel carcinogenesis.	ros	147-150	AKT serine/threonine kinase 1	Homo sapiens	62-65
21852236-4	2011	Suppression of GPx-1 enhanced TNF-alpha-induced ROS production and ICAM-1 expression, whereas overexpression of GPx-1 attenuated these TNF-alpha-mediated responses.	ros	48-51	tumor necrosis factor	Homo sapiens	30-39
21852236-7	2011	To analyze further signaling pathways involved in GPx-1-mediated protection from TNF-alpha-induced ROS, we performed microarray analysis of human microvascular endothelial cells treated with TNF-alpha in the presence and absence of GPx-1.	ros	99-102	tumor necrosis factor	Homo sapiens	81-90
21762757-9	2011	The EGFR-induced ERK phosphorylation and ROS-mediated NFkappaB activation were involved in the cytokine and angiogenic factor release.	ros	41-44	epidermal growth factor receptor	Homo sapiens	4-8
21863242-12	2011	Our data establish NG2 as an important prognostic factor for GBM patient survival, by mediating resistance to radiotherapy through induction of ROS scavenging enzymes and preferential DNA damage signalling.	ros	144-147	chondroitin sulfate proteoglycan 4	Homo sapiens	19-22
22100796-2	2011	Both enzymes, catalase and superoxide dismutase, practically do not penetrate biological membranes, which limits or even makes impossible their protective activity directed against ROS.	ros	181-184	catalase	Homo sapiens	14-22
21789651-7	2011	Bile acid-induced apoptosis is a result of oxidative stress with increased ROS generation mainly by activation of plasma membrane enzymes, such as NAD(P)H oxidases and, to a lower extent, PLA2.	ros	75-78	phospholipase A2 group IB	Homo sapiens	188-192
21499310-4	2011	The effects of LXA(4), ANXA1, SAA and LL-37 were dependent on the activation of their mutual cell-surface receptor formyl peptide receptor-2 (FPR2) and subsequent ROS-MAPK-NF-kB signalings.	ros	163-166	cathelicidin antimicrobial peptide	Homo sapiens	38-43
21763267-8	2011	ATP stimulated the proliferation of both ROS 17/2.8 cells and rat osteoblasts through PI3K/Akt.	ros	41-44	AKT serine/threonine kinase 1	Rattus norvegicus	91-94
21763267-1	2011	We studied the PI3K/Akt signaling pathway modulation and its involvement in the stimulation of ROS 17/2.8 osteoblast-like cell proliferation by extracellular ATP.	ros	95-98	AKT serine/threonine kinase 1	Rattus norvegicus	20-23
21794086-7	2011	Additionally, neutrophil accumulation and lipid peroxidase-mediated tissue injury, detected by MPO, MDA and ROS respectively, were attenuated after Gal-LipoNP TLR4 siRNA treatment.	ros	108-111	toll-like receptor 4	Mus musculus	159-163
21862870-2	2011	Furthermore, PGC1alpha protects against colon cancer formation by promoting ROS accumulation and, consequently, mitochondria-mediated apoptosis.	ros	76-79	PPARG coactivator 1 alpha	Homo sapiens	13-22
21669192-7	2011	Here, we demonstrated that IR-induced ROS activated cyclooxygenases-2 (COX-2) and 5-lipoxygenase (5-LOX) pathway in HFL-1 and MRC-5 cells.	ros	38-41	arachidonate 5-lipoxygenase	Homo sapiens	82-96
21294650-9	2011	Taken together, our data evidently show that Abeta is toxic to brain endothelial cells via binding to RAGE and induction of ROS production, which ultimately leads to disruption of TJs and loss of BBB integrity.	ros	124-127	amyloid beta precursor protein	Homo sapiens	45-50
21425328-11	2011	In conclusion, ROS dependent-ATM/p53 signaling pathway is involved in HMJ-30-induced apoptosis in U-2 OS cells.	ros	15-18	tumor protein p53	Homo sapiens	33-36
21663396-12	2011	These data suggest that the TGF-beta-mediated ROS/RNS production reaches a maximum at low doses or fluences of particles, leading to a plateau in radiation-stimulated intercellular induction of apoptosis at higher doses.	ros	46-49	transforming growth factor, beta 1	Rattus norvegicus	28-36
21708260-8	2011	Rottlerin was more potent than Go6976 to attenuate ERK1/2 phosphorylation and ROS generation induced by SIN-1 or zinc.	ros	78-81	MAPK associated protein 1	Homo sapiens	104-109
21852776-0	2011	A "Tsc, Tsc" keeps the kids quie(scen)t and holds down ROS.	ros	55-58	TSC complex subunit 1	Homo sapiens	3-6
21861928-8	2011	ROS scavenger (N-acetyl-L-cysteine, NAC) blocked the PPCSE-induced ROS generation and HO-1 expression.	ros	0-3	heme oxygenase 1	Mus musculus	86-90
21861928-10	2011	In addition, we found that PPCSE induced PI3K/Akt activation via NADPH oxidase/ROS-dependent PDGFR phosphorylation.	ros	79-82	thymoma viral proto-oncogene 1	Mus musculus	46-49
21852776-0	2011	A "Tsc, Tsc" keeps the kids quie(scen)t and holds down ROS.	ros	55-58	TSC complex subunit 1	Homo sapiens	8-12
21453688-0	2011	Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells.	ros	65-68	mitogen-activated protein kinase 1	Homo sapiens	79-82
21453688-0	2011	Vitamin K3-2,3-epoxide induction of apoptosis with activation of ROS-dependent ERK and JNK protein phosphorylation in human glioma cells.	ros	65-68	mitogen-activated protein kinase 8	Homo sapiens	87-90
21453688-4	2011	An increase in the intracellular ROS level by EPO1 was observed in the DCHF-DA analysis, and EPO1-induced apoptosis and caspase 3 protein cleavage were prevented by adding the antioxidant, N-acetyl-cysteine (NAC), with decreased ROS production elicited by EPO1.	ros	229-232	caspase 3	Homo sapiens	120-129
21788490-5	2011	Using a rat model of I/R, we show that circulating levels of TNF-alpha and cardiac caspase-8 activity were increased within 6 h of reperfusion, leading to myocardial nitric oxide and mitochondrial ROS production.	ros	197-200	tumor necrosis factor	Rattus norvegicus	61-70
21806969-3	2011	mkk4 mutants were more sensitive to high salt concentration than WT plants, exhibiting higher water-loss rates under dehydration conditions and additionally accumulating high levels of ROS.	ros	185-188	mitogen-activated protein kinase kinase 4	Arabidopsis thaliana	0-4
22108328-5	2011	These results illustrated that POX upregulation and ROS formation in apoptosis induced by troglitazone was modulated in PPARgamma-dependent pattern.	ros	52-55	peroxisome proliferator activated receptor gamma	Homo sapiens	120-129
22108328-0	2011	Troglitazone induced apoptosis via PPARgamma activated POX-induced ROS formation in HT29 cells.	ros	67-70	peroxisome proliferator activated receptor gamma	Homo sapiens	35-44
21732177-6	2011	Further, IL-6 treatment led to decreased mitochondrial membrane potential, decreased cellular ATP production, and increased intracellular ROS levels.	ros	138-141	interleukin 6	Homo sapiens	9-13
21549799-5	2011	Meanwhile, the data showed that olaquindox triggered ROS-mediated apoptosis in HepG2 cells correlated with both the mitochondrial DNA damage and nuclear DNA damage, collapse of Deltapsi(m), opening of mPTP, down-regulation of Bcl-2 and up-regulation of Bax.	ros	53-56	BCL2 apoptosis regulator	Homo sapiens	226-231
21809503-6	2011	This suggests that MAO-B-mediated ROS contributes to neuropathology associated with this model and that antioxidant treatment can arrest further progression of dopaminergic cell death.	ros	34-37	monoamine oxidase B	Mus musculus	19-24
21670990-10	2011	Increased connexin-43 immunofluorescence was observed in glomeruli of WKY-ROS and SHR-ROS.	ros	74-77	gap junction protein, alpha 1	Rattus norvegicus	10-21
21670990-10	2011	Increased connexin-43 immunofluorescence was observed in glomeruli of WKY-ROS and SHR-ROS.	ros	86-89	gap junction protein, alpha 1	Rattus norvegicus	10-21
21549799-5	2011	Meanwhile, the data showed that olaquindox triggered ROS-mediated apoptosis in HepG2 cells correlated with both the mitochondrial DNA damage and nuclear DNA damage, collapse of Deltapsi(m), opening of mPTP, down-regulation of Bcl-2 and up-regulation of Bax.	ros	53-56	BCL2 associated X, apoptosis regulator	Homo sapiens	253-256
21521714-5	2011	Focused qPCR array revealed alteration of gene profiles in the DNA damage response (DDR) and anti-reactive oxygen species (ROS) pathways in TR4(-/-) MEFs, which further supports the hypothesis that the premature aging in TR4(-/-) mice might stem from oxidative DNA damage caused by increased oxidative stress or compromised genome integrity.	ros	123-126	nuclear receptor subfamily 2, group C, member 2	Mus musculus	140-143
21620957-0	2011	ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation.	ros	0-3	mitogen-activated protein kinase 1	Homo sapiens	23-26
21620957-0	2011	ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	27-30
21620957-6	2011	The employment of several inhibitors and antioxidants indicates that a ROS-induced stress-sensitive p38 MAPK/ERK-Akt cascade plays a critical role in the regulation of PA on cell cycle and cell proliferation.	ros	71-74	mitogen-activated protein kinase 1	Homo sapiens	109-112
21620957-6	2011	The employment of several inhibitors and antioxidants indicates that a ROS-induced stress-sensitive p38 MAPK/ERK-Akt cascade plays a critical role in the regulation of PA on cell cycle and cell proliferation.	ros	71-74	AKT serine/threonine kinase 1	Homo sapiens	113-116
21620957-7	2011	Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation.	ros	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	49-53
21620957-7	2011	Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation.	ros	84-87	mitogen-activated protein kinase 1	Homo sapiens	120-123
21620957-7	2011	Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation.	ros	84-87	AKT serine/threonine kinase 1	Homo sapiens	124-127
21620957-7	2011	Moreover, PA dose and time dependently activates Nrf2 and this activation relies on ROS-induced stimulation of p38 MAPK/ERK-Akt signaling, demonstrating that Nrf2 activation may be associated with the regulation of PA on cell cycle transition and proliferation.	ros	84-87	NFE2 like bZIP transcription factor 2	Homo sapiens	158-162
21620957-8	2011	In conclusion, our study elucidates the importance of PA metabolism on cell proliferation, and suggests that PA stimulates hepatocyte proliferation through activating the ROS-p38 MAPK/ERK-Akt cascade which is intersected with the activation of Nrf2 and that the effect of ROS on signal transduction is in a dose- and time-dependent manner.	ros	171-174	mitogen-activated protein kinase 1	Homo sapiens	184-187
21620957-8	2011	In conclusion, our study elucidates the importance of PA metabolism on cell proliferation, and suggests that PA stimulates hepatocyte proliferation through activating the ROS-p38 MAPK/ERK-Akt cascade which is intersected with the activation of Nrf2 and that the effect of ROS on signal transduction is in a dose- and time-dependent manner.	ros	171-174	AKT serine/threonine kinase 1	Homo sapiens	188-191
21620957-8	2011	In conclusion, our study elucidates the importance of PA metabolism on cell proliferation, and suggests that PA stimulates hepatocyte proliferation through activating the ROS-p38 MAPK/ERK-Akt cascade which is intersected with the activation of Nrf2 and that the effect of ROS on signal transduction is in a dose- and time-dependent manner.	ros	171-174	NFE2 like bZIP transcription factor 2	Homo sapiens	244-248
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	AKT serine/threonine kinase 1	Homo sapiens	203-206
21530647-2	2011	Activation of the redox-sensitive transcription factor Nrf2 by low levels of ROS is known to protect against oxidative stress-induced cell death.	ros	77-80	nuclear factor, erythroid derived 2, like 2	Mus musculus	55-59
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	AKT serine/threonine kinase 1	Homo sapiens	203-206
21543583-5	2011	IL-12 treatment induces NK cell activation as well as levels of ROS, but prolonged IL-12 treatment causes ROS accumulation, which in turn, results in the loss of Deltapsi(m), the release of cytochrome c, and the activation of caspase-3, resulting in NK cell apoptosis.	ros	106-109	cytochrome c, somatic	Homo sapiens	190-202
21670495-5	2011	The generation of prothrombotic MPs required P2X7 receptor-dependent production of ROS leading to increased availability of solvent-accessible extracellular thiols.	ros	83-86	purinergic receptor P2X, ligand-gated ion channel, 7	Mus musculus	45-58
21543583-5	2011	IL-12 treatment induces NK cell activation as well as levels of ROS, but prolonged IL-12 treatment causes ROS accumulation, which in turn, results in the loss of Deltapsi(m), the release of cytochrome c, and the activation of caspase-3, resulting in NK cell apoptosis.	ros	106-109	caspase 3	Homo sapiens	226-235
21620800-6	2011	siRNA-induced knockdown of CPEB1 expression inhibited the LPS-induced up-regulation of iNOS as well as NO and ROS production, a hallmark of immunological activation of astrocytes.	ros	110-113	cytoplasmic polyadenylation element binding protein 1	Rattus norvegicus	27-32
21624350-6	2011	Moreover, when the free radical (ROS) generating capacity of the compounds was studied by 2",7"-dichlorofluorescein-diacetate assay using flow cytometry, we found that a known antioxidant N-acetyl-cysteine almost completely abrogated the H2AX((S139)) phosphorylations and the caspase 3 cleavage and activation.	ros	33-36	caspase 3	Homo sapiens	276-285
21421815-8	2011	To determine whether PTEN relocalization to mitochondria was influenced by I/R-induced production of ROS, hearts were perfused with N-acetylcysteine (NAC) to scavenge ROS or H(2)O(2) to mimic I/R-induced ROS.	ros	101-104	phosphatase and tensin homolog	Mus musculus	21-25
21367916-3	2011	In this study, we examined the hypothesis that ANG-(1-7) attenuates ANG II-induced reactive oxygen species stress (ROS)-mediated injury in type 2 diabetic nephropathy of KK-A(y)/Ta mice.	ros	115-118	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	68-74
21367916-9	2011	These findings were related to improved mesangial expansion and to fibronectin and transforming growth factor-beta1 production in response to ANG II and suggest that ANG-(1-7) may attenuate ANG II-stimulated ROS-mediated injury in type 2 diabetic nephropathy.	ros	208-211	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	142-148
21421815-11	2011	PTEN overexpression increased mitochondrial PTEN and Bax protein levels and ROS production, whereas muscle-specific PTEN knockout produced the opposite effects.	ros	76-79	phosphatase and tensin homolog	Mus musculus	0-4
21421815-12	2011	In conclusion, myocardial I/R causes PTEN localization to the mitochondria, related to the generation of ROS; IPC attenuates the mitochondrial localization of PTEN after I/R, potentially inhibiting the translocation of Bax to the mitochondria and resulting in improved cell viability.	ros	105-108	phosphatase and tensin homolog	Mus musculus	37-41
21480623-10	2011	In conclusion, the data suggest that ellagic acid elicits its protective effects by modulating the PKC-alpha/ERK/PPAR-gamma/NF-kappaB pathway, resulting in the suppression of ROS generation and, ultimately, inhibition of MMP-1 and MMP-3 expression in HUVECs exposed to oxLDL.	ros	175-178	peroxisome proliferator activated receptor gamma	Homo sapiens	113-123
21382475-5	2011	Treatment with glucocorticoid (corticosterone) and Abeta in SH-SY5Y cells increased the expression of 17beta-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells suppressed glucocorticoid-enhanced mitochondrial dysfunction and ROS accumulation.	ros	187-190	amyloid beta precursor protein	Homo sapiens	51-56
21382475-5	2011	Treatment with glucocorticoid (corticosterone) and Abeta in SH-SY5Y cells increased the expression of 17beta-hydroxysteroid dehydrogenase (ABAD), mitochondrial dysfunction, and levels of ROS, whereas blockade of ABAD expression by siRNA-ABAD in SH-SY5Y cells suppressed glucocorticoid-enhanced mitochondrial dysfunction and ROS accumulation.	ros	324-327	amyloid beta precursor protein	Homo sapiens	51-56
21463325-1	2011	The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-regulated early in the mouse brain in response to the ROS generator paraquat.	ros	185-188	apolipoprotein D	Mus musculus	14-30
21463325-1	2011	The lipocalin Apolipoprotein D (ApoD), known to protect the nervous system against oxidative stress (OS) in model organisms, is up-regulated early in the mouse brain in response to the ROS generator paraquat.	ros	185-188	apolipoprotein D	Mus musculus	32-36
21276206-11	2011	G-CSF could also prevent cardiac mitochondrial swelling, decrease ROS production, and prevent mitochondrial membrane depolarization.	ros	66-69	colony stimulating factor 3	Sus scrofa	0-5
21572963-5	2011	Furthermore, TNF-alpha-induced NF-kappaB activation assessed by IkappaBalpha degradation and p65 phosphorylation and nuclear translocation and ROS production were diminished in cells subjected to treatment with NaHS.	ros	143-146	tumor necrosis factor	Homo sapiens	13-22
21295083-13	2011	Importantly, the prevention of ROS production by antioxidants attenuated LA-stimulated ERK activation and completely abolished LA-promoted neurite outgrowth.	ros	31-34	mitogen-activated protein kinase 1	Mus musculus	87-90
21335461-3	2011	We hypothesized that overexpression of an antioxidant network (AON) composed of SOD1, SOD3, and glutathione peroxidase (GSHPx)-1 would reduce myocardial ischemia-reperfusion injury by limiting ROS-mediated lipid peroxidation and oxidative posttranslational modification (OPTM) of proteins.	ros	193-196	superoxide dismutase 1, soluble	Mus musculus	80-84
21335461-6	2011	These data demonstrate that concomitant SOD1, SOD3, and GSHPX-1 expression confers marked protection against myocardial ischemia-reperfusion injury, reducing ROS, ROS-mediated lipid peroxidation, and OPTM of critical cardiac proteins, including cardiac fatty acid-binding protein and SERCA2a.	ros	158-161	superoxide dismutase 1, soluble	Mus musculus	40-44
21335461-6	2011	These data demonstrate that concomitant SOD1, SOD3, and GSHPX-1 expression confers marked protection against myocardial ischemia-reperfusion injury, reducing ROS, ROS-mediated lipid peroxidation, and OPTM of critical cardiac proteins, including cardiac fatty acid-binding protein and SERCA2a.	ros	163-166	superoxide dismutase 1, soluble	Mus musculus	40-44
21295083-14	2011	CONCLUSION: Our data suggest that LA stimulates neurite outgrowth through the activation of ERK signaling, an effect mediated through a ROS-dependent mechanism.	ros	136-139	mitogen-activated protein kinase 1	Mus musculus	92-95
21645446-14	2011	The ozonized saline, as a novel Nrf2 activator, can reduce the oxidative damage of radical oxygen species (ROS) and the deleterious substance by activating the Keap1-Nrf2-ARE signaling pathway and its downstream genes expression.	ros	107-110	NFE2 like bZIP transcription factor 2	Rattus norvegicus	32-36
21335603-12	2011	Src-induced ROS reduces cellular vitamin C, which is required for the activity of PHD2, thus Src can block VHL recruitment of HIF-1alpha, leading to stabilization of HIF-1alpha.	ros	12-15	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
21335603-12	2011	Src-induced ROS reduces cellular vitamin C, which is required for the activity of PHD2, thus Src can block VHL recruitment of HIF-1alpha, leading to stabilization of HIF-1alpha.	ros	12-15	egl-9 family hypoxia inducible factor 1	Homo sapiens	82-86
21335603-12	2011	Src-induced ROS reduces cellular vitamin C, which is required for the activity of PHD2, thus Src can block VHL recruitment of HIF-1alpha, leading to stabilization of HIF-1alpha.	ros	12-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	126-136
21335603-12	2011	Src-induced ROS reduces cellular vitamin C, which is required for the activity of PHD2, thus Src can block VHL recruitment of HIF-1alpha, leading to stabilization of HIF-1alpha.	ros	12-15	hypoxia inducible factor 1 subunit alpha	Homo sapiens	166-176
21276840-4	2011	IL-11 (20 ng/ml) increased BSP mRNA and protein levels at 12h in osteoblast-like ROS 17/2.8 cells.	ros	81-84	integrin-binding sialoprotein	Rattus norvegicus	27-30
21519140-0	2011	Mitochondrial Ca2+ and ROS take center stage to orchestrate TNF-alpha-mediated inflammatory responses.	ros	23-26	tumor necrosis factor	Homo sapiens	60-69
21519140-5	2011	demonstrate that in lung microvessels, soluble TNF-alpha (sTNF-alpha) promotes the shedding of the TNF-alpha receptor 1 ectodomain via increased mitochondrial Ca2+ that leads to release of mitochondrial ROS.	ros	203-206	tumor necrosis factor	Homo sapiens	47-56
21519140-5	2011	demonstrate that in lung microvessels, soluble TNF-alpha (sTNF-alpha) promotes the shedding of the TNF-alpha receptor 1 ectodomain via increased mitochondrial Ca2+ that leads to release of mitochondrial ROS.	ros	203-206	tumor necrosis factor	Homo sapiens	59-68
21335603-11	2011	HIF-1alpha-hydroxylation-dependent VHL pull-down assay showed that Src inhibits cellular PHD2 activity by inducing ROS production in a mechanism involving Rac1-dependent NADPH oxidase.	ros	115-118	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21335603-11	2011	HIF-1alpha-hydroxylation-dependent VHL pull-down assay showed that Src inhibits cellular PHD2 activity by inducing ROS production in a mechanism involving Rac1-dependent NADPH oxidase.	ros	115-118	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	67-70
21335603-11	2011	HIF-1alpha-hydroxylation-dependent VHL pull-down assay showed that Src inhibits cellular PHD2 activity by inducing ROS production in a mechanism involving Rac1-dependent NADPH oxidase.	ros	115-118	egl-9 family hypoxia inducible factor 1	Homo sapiens	89-93
21645446-14	2011	The ozonized saline, as a novel Nrf2 activator, can reduce the oxidative damage of radical oxygen species (ROS) and the deleterious substance by activating the Keap1-Nrf2-ARE signaling pathway and its downstream genes expression.	ros	107-110	NFE2 like bZIP transcription factor 2	Rattus norvegicus	166-170
21501525-10	2011	Silibinin caused ROS generation and its effect was inhibited by calpain inhibitor, the general PKC inhibitor GF 109203X, the specific PKCdelta inhibitor rottlerin, and catalase.	ros	17-20	catalase	Homo sapiens	134-176
21414301-9	2011	Taken together, our results indicate that celastrol can activate the ROS-ERK/p38-Nrf2-ARE signaling cascades leading to the up-regulation of HO-1 which is partly responsible for its anti-inflammatory activity in the keratinocytes.	ros	69-72	mitogen-activated protein kinase 14	Homo sapiens	77-80
21414301-9	2011	Taken together, our results indicate that celastrol can activate the ROS-ERK/p38-Nrf2-ARE signaling cascades leading to the up-regulation of HO-1 which is partly responsible for its anti-inflammatory activity in the keratinocytes.	ros	69-72	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
21673371-0	2011	Trans fatty acids induce a proinflammatory response in endothelial cells through ROS-dependent nuclear factor-kappaB activation.	ros	81-84	nuclear factor kappa B subunit 1	Homo sapiens	95-116
21607879-8	2011	We also observed that intracellular ROS, mitochondrial morphology, and mitochondrial mtDNA copy number were maintained upon UCP4 expression, with no change in mitochondrial fusion and fission.	ros	36-39	solute carrier family 25, member 27	Mus musculus	124-128
21673371-13	2011	CONCLUSION: TFAs present in our diet have a direct proinflammatory effect, which promotes leukocyte adhesion to the endothelium through ROS-dependent NF-kappaB activation.	ros	136-139	nuclear factor kappa B subunit 1	Homo sapiens	150-159
21533077-8	2011	We demonstrate that the cells harboring the mouse or human mutant tRNA have exacerbated mitochondrial biogenesis triggered by an increase in mitochondrial ROS production as a compensatory response.	ros	155-158	mitochondrially encoded tRNA glycine	Homo sapiens	66-70
21194832-7	2011	Blockage of ROS by NAC or catalase inhibited the activation of NF-kappaB signaling and enhanced Rh2-induced cell death, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants.	ros	12-15	catalase	Homo sapiens	26-34
21266576-5	2011	Moreover, we show that HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling in both SkBr3 and HL-1 and cells.	ros	173-176	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
21266576-5	2011	Moreover, we show that HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling in both SkBr3 and HL-1 and cells.	ros	173-176	epidermal growth factor receptor	Homo sapiens	199-203
21345685-6	2011	N-acetylcysteine (NAC) treatment abolished p38 phosphorylation as well as HO-1 induction caused by SC-1, indicating that ROS are upstream signals of p38 in Nrf2/ARE activation by SC-1.	ros	121-124	NFE2 like bZIP transcription factor 2	Rattus norvegicus	156-160
21163346-3	2011	Experimental and clinical data suggest an inverse association between insulin sensitivity and ROS levels.	ros	94-97	insulin	Homo sapiens	70-77
21479273-12	2011	The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.	ros	19-22	calmodulin 1	Homo sapiens	23-33
20352258-2	2011	Mitochondrial production of ROS stabilizes the O(2)-regulated HIF-1alpha subunit of the HIF-1 dimer promoting transaction functions in a large number of potential target genes, activating transcription of sequences into RNA and, eventually, protein production.	ros	28-31	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67
21219240-8	2011	EXPERT OPINION: Although SASP and 5-aminosalicylic acid also scavenge ROS, which may account for some of their anti-inflammatory properties, the reaction with ROS may also generate toxic free radicals; hence, the ability of other antioxidants to suppress the toxicity of SASP in vivo.	ros	70-73	aspartic peptidase retroviral like 1	Homo sapiens	25-29
21219240-8	2011	EXPERT OPINION: Although SASP and 5-aminosalicylic acid also scavenge ROS, which may account for some of their anti-inflammatory properties, the reaction with ROS may also generate toxic free radicals; hence, the ability of other antioxidants to suppress the toxicity of SASP in vivo.	ros	159-162	aspartic peptidase retroviral like 1	Homo sapiens	25-29
21219240-8	2011	EXPERT OPINION: Although SASP and 5-aminosalicylic acid also scavenge ROS, which may account for some of their anti-inflammatory properties, the reaction with ROS may also generate toxic free radicals; hence, the ability of other antioxidants to suppress the toxicity of SASP in vivo.	ros	159-162	aspartic peptidase retroviral like 1	Homo sapiens	271-275
21359283-6	2011	Copper ions entrapped in Abeta fibrils are electrochemically active and can generate ROS in the presence of hydrogen peroxide and reducing agents.	ros	85-88	amyloid beta precursor protein	Homo sapiens	25-30
21419037-5	2011	Fluorescence enzyme-labelled meter was used to measure the effects of Sal on ROS of H(2);DCFDA-labelled macrophages induced by LPS and IFN-gamma.	ros	77-80	interferon gamma	Mus musculus	135-144
21419037-10	2011	Fluorescence enzyme-labelled meter showed that Sal could reduce the production of ROS in activated peritoneal macrophages induced by LPS and IFN-gamma(P&lt;0.05).	ros	82-85	interferon gamma	Mus musculus	141-150
21304825-0	2011	Stage-specific expression of TNFalpha regulates bad/bid-mediated apoptosis and RIP1/ROS-mediated secondary necrosis in Birnavirus-infected fish cells.	ros	84-87	tumor necrosis factor	Homo sapiens	29-37
21304825-2	2011	We found that IPNV infection can regulate Bad/Bid-mediated apoptotic and Rip1/ROS-mediated necrotic death pathways via the up-regulation of TNFalpha in zebrafish ZF4 cells.	ros	78-81	tumor necrosis factor	Homo sapiens	140-148
21304825-9	2011	Inhibition of TNFalpha expression dramatically reduced the Bad/Bid-mediated apoptotic and Rip1/ROS-mediated necrotic cell death pathways and rescued host cell viability.	ros	95-98	tumor necrosis factor	Homo sapiens	14-22
21268073-6	2011	The results revealed all of the truncated rhodopsin fragments except for the C-terminal domain and the full-length rhodopsin which had some plasma membrane localization, formed aggregates nearby or within the ER in COS-1 cells; however, the N-terminally truncated rhodopsin fragment, the C-terminal domain, and the full-length rhodopsin could traffic to the ROS in the zebrafish.	ros	358-361	rhodopsin	Homo sapiens	115-124
21250674-5	2011	Analysis of the SPR signatures revealed two cluster groups corresponding to (i) sublethal pro-inflammatory responses to Al2O3, Au, Ag, SiO2 nanoparticles possibly related to ROS generation, and (ii) lethal genotoxic responses due to exposure to ZnO and Pt nanoparticles at a concentration range of 25-100 mug/mL at 12 h exposure.	ros	174-177	sepiapterin reductase	Mus musculus	16-19
21268073-6	2011	The results revealed all of the truncated rhodopsin fragments except for the C-terminal domain and the full-length rhodopsin which had some plasma membrane localization, formed aggregates nearby or within the ER in COS-1 cells; however, the N-terminally truncated rhodopsin fragment, the C-terminal domain, and the full-length rhodopsin could traffic to the ROS in the zebrafish.	ros	358-361	rhodopsin	Homo sapiens	115-124
21268073-6	2011	The results revealed all of the truncated rhodopsin fragments except for the C-terminal domain and the full-length rhodopsin which had some plasma membrane localization, formed aggregates nearby or within the ER in COS-1 cells; however, the N-terminally truncated rhodopsin fragment, the C-terminal domain, and the full-length rhodopsin could traffic to the ROS in the zebrafish.	ros	358-361	rhodopsin	Homo sapiens	115-124
21258760-7	2011	Preincubation of neutrophils with Vsto vesicles results in an enhanced ROS generation by neutrophils,which is further increased upon fMLP stimulation and during zymosan phagocytosis.	ros	71-74	formyl peptide receptor 1	Homo sapiens	133-137
20940027-5	2011	Furthermore, western blot analysis of p53, JNK, and caspase-3 showed that ROS generation was accompanied by JNK activation.	ros	74-77	tumor protein p53	Homo sapiens	38-41
20940027-5	2011	Furthermore, western blot analysis of p53, JNK, and caspase-3 showed that ROS generation was accompanied by JNK activation.	ros	74-77	mitogen-activated protein kinase 8	Homo sapiens	43-46
21070851-5	2011	Furthermore, anandamide induced enhanced cell death in human cardiomyocytes pretreated with FAAH inhibitor and enhanced sensitivity to ROS generation in inflammatory cells of FAAH knockouts.	ros	135-138	fatty acid amide hydrolase	Homo sapiens	175-179
20940027-5	2011	Furthermore, western blot analysis of p53, JNK, and caspase-3 showed that ROS generation was accompanied by JNK activation.	ros	74-77	caspase 3	Homo sapiens	52-61
20940027-5	2011	Furthermore, western blot analysis of p53, JNK, and caspase-3 showed that ROS generation was accompanied by JNK activation.	ros	74-77	mitogen-activated protein kinase 8	Homo sapiens	108-111
21779360-9	2011	Taken together, the findings of the present study have demonstrated for the first time that H(2)S protects HaCaT cells against CoCl(2)-induced injuries and inflammatory responses through inhibition of ROS-activated NF-kappaB/COX-2 pathway.	ros	201-204	nuclear factor kappa B subunit 1	Homo sapiens	215-224
21196188-2	2011	Reactive oxygen/nitrogen species (ROS/RNS), normally produced in the heart, promote endogenous RyR2 S-nitrosylation and S-glutathionylation.	ros	34-37	ryanodine receptor 2	Homo sapiens	95-99
21196188-7	2011	Likewise, the physiological sources of ROS/RNS responsible for functionally relevant RyR2 redox modifications have not been completely identified.	ros	39-42	ryanodine receptor 2	Homo sapiens	85-89
21123941-7	2011	Accumulation of unrepaired DNA following XPC silencing increased DNA-dependent protein kinase activity, which subsequently activated AKT1 and NADPH oxidase-1 (NOX1), resulting in ROS production and accumulation of specific deletions in mitochondrial DNA (mtDNA) over time.	ros	179-182	AKT serine/threonine kinase 1	Homo sapiens	133-137
21123941-10	2011	Our results demonstrate that genomic instability resulting from XPC silencing results in activation of AKT1 and subsequently NOX1 to induce ROS generation, mtDNA deletions, and neoplastic transformation in human keratinocytes.	ros	140-143	AKT serine/threonine kinase 1	Homo sapiens	103-107
22046279-9	2011	In primary macrophages isolated form C57/BL6 male mice, we identify mitochondrial ROS formation by CO as the upstream trigger for the observed effects on Egr-1 in part through uncoupling protein 2 (UCP2).	ros	82-85	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	176-196
22046279-9	2011	In primary macrophages isolated form C57/BL6 male mice, we identify mitochondrial ROS formation by CO as the upstream trigger for the observed effects on Egr-1 in part through uncoupling protein 2 (UCP2).	ros	82-85	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	198-202
22046279-10	2011	Macrophages derived from bone marrow isolated from Ucp2 gene Knock-Out C57/BL6 mice (Ucp2(-/-)), produced significantly less ROS with CO exposure versus wild-type macrophages.	ros	125-128	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	51-55
22046279-10	2011	Macrophages derived from bone marrow isolated from Ucp2 gene Knock-Out C57/BL6 mice (Ucp2(-/-)), produced significantly less ROS with CO exposure versus wild-type macrophages.	ros	125-128	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	85-89
22046279-12	2011	Collectively, these results indentify p38 activation, PPARgamma-SUMOylation and ROS formation via UCP2 as a cooperative system by which CO impacts the inflammatory response.	ros	80-83	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	98-102
21031461-6	2011	PARP1 activity in 30 mM-glucose-treated cells was more than that in 5.5 mM-glucose-treated cells, and the activity correlated with the increase in ROS generation and DNA damage.	ros	147-150	poly(ADP-ribose) polymerase 1	Homo sapiens	0-5
21998736-5	2011	Combined treatment of NQO1(+) cells induced ROS generation, triggered ER stress and stimulated activation of ERK and JNK.	ros	44-47	NAD(P)H quinone dehydrogenase 1	Homo sapiens	22-26
21998736-6	2011	Inhibition of ROS generation by NAC effectively attenuated the activation of ERK and JNK, induction of ER stress, and subsequent apoptosis.	ros	14-17	mitogen-activated protein kinase 1	Homo sapiens	77-80
21998736-6	2011	Inhibition of ROS generation by NAC effectively attenuated the activation of ERK and JNK, induction of ER stress, and subsequent apoptosis.	ros	14-17	mitogen-activated protein kinase 8	Homo sapiens	85-88
21998736-7	2011	Importantly, inhibition of ERK abolished ROS generation and ER stress, whereas inhibition of JNK did not, indicating that positive feedback regulation between ERK activation and ROS generation triggers ER stress in response to combined treatment.	ros	41-44	mitogen-activated protein kinase 1	Homo sapiens	27-30
21998736-7	2011	Importantly, inhibition of ERK abolished ROS generation and ER stress, whereas inhibition of JNK did not, indicating that positive feedback regulation between ERK activation and ROS generation triggers ER stress in response to combined treatment.	ros	41-44	mitogen-activated protein kinase 1	Homo sapiens	159-162
21998736-7	2011	Importantly, inhibition of ERK abolished ROS generation and ER stress, whereas inhibition of JNK did not, indicating that positive feedback regulation between ERK activation and ROS generation triggers ER stress in response to combined treatment.	ros	178-181	mitogen-activated protein kinase 1	Homo sapiens	27-30
21998736-12	2011	When NQO1(+) cells are treated with combination of IR and beta-lap, positive feedback regulation between ERK and ROS leads to ER stress causing JNK activation and mitochondrial translocation of cleaved Bax.	ros	113-116	NAD(P)H quinone dehydrogenase 1	Homo sapiens	5-9
21998736-12	2011	When NQO1(+) cells are treated with combination of IR and beta-lap, positive feedback regulation between ERK and ROS leads to ER stress causing JNK activation and mitochondrial translocation of cleaved Bax.	ros	113-116	mitogen-activated protein kinase 8	Homo sapiens	144-147
21998736-12	2011	When NQO1(+) cells are treated with combination of IR and beta-lap, positive feedback regulation between ERK and ROS leads to ER stress causing JNK activation and mitochondrial translocation of cleaved Bax.	ros	113-116	BCL2 associated X, apoptosis regulator	Homo sapiens	202-205
21779360-9	2011	Taken together, the findings of the present study have demonstrated for the first time that H(2)S protects HaCaT cells against CoCl(2)-induced injuries and inflammatory responses through inhibition of ROS-activated NF-kappaB/COX-2 pathway.	ros	201-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	225-230
21647434-3	2011	The generation of ROS was inhibited by catalase and EUK-134.	ros	18-21	catalase	Homo sapiens	39-47
20861020-1	2010	Uncoupling of NO production from NADPH oxidation by endothelial nitric-oxide synthase (eNOS) is enhanced in hyperglycemic endothelium, potentially due to dissociation of heat shock proteins 90 (Hsp90), and cellular glucose homeostasis is enhanced by a ROS-induced positive feed back mechanism.	ros	252-255	nitric oxide synthase 3	Bos taurus	52-85
21647434-12	2011	Over-expression of catalase by transient transfection protected the cells from capsaicin-mediated ROS generation and apoptosis.	ros	98-101	catalase	Homo sapiens	19-27
20802255-11	2010	CONCLUSIONS: Adiponectin prevents EPC senescence by inhibiting the ROS/p38 MAPK/p16(INK4A) signaling cascade.	ros	67-70	cyclin dependent kinase inhibitor 2A	Mus musculus	80-83
21042727-6	2010	In the presence of p53, increased ROS from OXPHOS increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR).	ros	34-37	tumor protein p53	Homo sapiens	19-22
21042727-6	2010	In the presence of p53, increased ROS from OXPHOS increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR).	ros	34-37	tumor protein p53	Homo sapiens	78-81
20846705-8	2010	These results suggest that the translocation of PKC-delta was mediated by ROS-dependent caspase-3 activity.	ros	74-77	caspase 3	Homo sapiens	88-97
20846705-10	2010	Taken together, this study suggests that ROS generation is an upstream event for TCDD-induced chondrocyte apoptosis and PKC-delta mediates the apoptotic processes through ROS-dependent caspase-3 activation.	ros	171-174	caspase 3	Homo sapiens	185-194
20568122-5	2010	NADPH oxidase-dependent ROS generation played a key role in CSE-induced HO-1 expression.	ros	24-27	heme oxygenase 1	Mus musculus	72-76
21099361-7	2010	In addition, p53-induced increases in intracellular levels of ROS were also inhibited in cells overexpressing Nek6.	ros	62-65	tumor protein p53	Homo sapiens	13-16
21109187-2	2010	In this issue of Cell Metabolism (Lee et al., 2010), older mice overexpressing mitochondrial targeted catalase had reduced muscle mitochondrial oxidative damage, lower intramuscular lipid, and improved insulin sensitivity, suggesting that enhanced ROS scavenging prevents age-associated mitochondrial impairments and insulin resistance.	ros	248-251	catalase	Mus musculus	102-110
21042774-8	2010	Our results showing S100b/RAGE expression on islets of diabetic rat model and RAGE ligands-induced islet cell apoptosis via NADPH oxidase-mediated ROS generation suggest that RAGE ligands-RAGE interaction may contribute not only to the development of diabetic complications but also to the progressive beta-cell loss in type 2 diabetes by inducing oxidative stress.	ros	147-150	advanced glycosylation end product-specific receptor	Rattus norvegicus	78-82
21042774-8	2010	Our results showing S100b/RAGE expression on islets of diabetic rat model and RAGE ligands-induced islet cell apoptosis via NADPH oxidase-mediated ROS generation suggest that RAGE ligands-RAGE interaction may contribute not only to the development of diabetic complications but also to the progressive beta-cell loss in type 2 diabetes by inducing oxidative stress.	ros	147-150	advanced glycosylation end product-specific receptor	Rattus norvegicus	78-82
21042774-8	2010	Our results showing S100b/RAGE expression on islets of diabetic rat model and RAGE ligands-induced islet cell apoptosis via NADPH oxidase-mediated ROS generation suggest that RAGE ligands-RAGE interaction may contribute not only to the development of diabetic complications but also to the progressive beta-cell loss in type 2 diabetes by inducing oxidative stress.	ros	147-150	advanced glycosylation end product-specific receptor	Rattus norvegicus	78-82
21234229-7	2010	These results suggest that Src tyrosine kinases may participate in the signaling event for ROS-dependent activation of MAPKs during neutrophil apoptosis induced by E. histolytica.	ros	91-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	27-30
21143681-9	2010	The results of this study support this hypothesis, as over-expression of GASA4 suppressed ROS accumulation and the transgenic seeds were partially resistant to the NO donor sodium nitroprusside (SNP).	ros	90-93	GAST1 protein homolog 4	Arabidopsis thaliana	73-78
20568122-8	2010	Taken together, these results suggested that, in bEnd.3 cells, CSE-induced HO-1 expression was mediated through PDGFR/JAK2/STAT3 cascade, which was regulated by c-Src or c-Src activated-NADPH oxidase/ROS.	ros	200-203	heme oxygenase 1	Mus musculus	75-79
20802255-11	2010	CONCLUSIONS: Adiponectin prevents EPC senescence by inhibiting the ROS/p38 MAPK/p16(INK4A) signaling cascade.	ros	67-70	cyclin dependent kinase inhibitor 2A	Mus musculus	84-89
20655384-7	2010	This suggests that MAO-B-mediated ROS contributes to neuropathology associated with this model and that antioxidant treatment can arrest further progression of dopaminergic cell death.	ros	34-37	monoamine oxidase B	Mus musculus	19-24
20638939-0	2010	Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.	ros	69-72	Ras-like without CAAX 2	Mus musculus	23-27
20066420-9	2010	Inhibition of HIF-1alpha appeared to be mediated through stabilization of PHD2, 3 and downregulation of ROS by MSC.	ros	104-107	hypoxia inducible factor 1 subunit alpha	Homo sapiens	14-24
20186475-4	2010	For instance, insulin inhibits NF-kappaB--dependent synthesis of pro-inflammatory factors and attenuates production of ROS.	ros	119-122	insulin	Homo sapiens	14-21
20717118-10	2010	Pre-treatment of stromal cells with TGF-beta1 enhanced this migratory stimulus by elevating NOX4 expression and intracellular ROS production.	ros	126-129	transforming growth factor beta 1	Homo sapiens	36-45
20717118-13	2010	The capacity of stromal cells to modify their intracellular ROS production, and accordingly, to increase epithelial motility, seems to depend on epithelial soluble factors among which TGF-beta1 have a decisive role.	ros	60-63	transforming growth factor beta 1	Homo sapiens	184-193
20581092-5	2010	Aortic ROS formation and ox-LDL uptake were increased in ApoE KO mice.	ros	7-10	apolipoprotein E	Mus musculus	57-61
20598695-11	2010	p21-overexpression significantly suppressed the DS-induced TXNIP expression, and inhibited the expression of vascular cell adhesion molecule 1 and chemokine (C-C motif) ligand 5 (CCL5/RANTES), which stimulates leukocyte recruitment and is downregulated by ROS scavenging.	ros	256-259	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
20435158-9	2010	The induction of IDO by IFN-gamma in HLE-B3 cells caused increases in intracellular ROS, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content.	ros	84-87	interferon gamma	Homo sapiens	24-33
20607689-12	2010	The mechanism of fibrosis may involve fructose inducing increased ROS associated with CD11b+F4/80+Gr1+ hepatic macrophage aggregation, resulting in transforming growth factor beta1-signaled collagen deposition and histologically visible hepatic fibrosis.	ros	66-69	integrin alpha M	Mus musculus	86-91
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	ros	116-119	mitogen-activated protein kinase 1	Homo sapiens	144-147
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	ros	116-119	mitogen-activated protein kinase 14	Homo sapiens	180-183
20432471-3	2010	Pretreatment with BAPTA-AM (Ca(2+) chelator) and N-acetylcysteine (ROS scavenger) abolished caffeine-induced ERK inactivation and p38 MPAK activation.	ros	67-70	mitogen-activated protein kinase 1	Homo sapiens	109-112
20432471-3	2010	Pretreatment with BAPTA-AM (Ca(2+) chelator) and N-acetylcysteine (ROS scavenger) abolished caffeine-induced ERK inactivation and p38 MPAK activation.	ros	67-70	mitogen-activated protein kinase 14	Homo sapiens	130-133
20451519-9	2010	We respond by presenting evidence of Abeta"s other activities, including protection against metal-induced reactive oxidizing species (ROS), modification of cholesterol transport, and potential activity as a transcription factor in its own right.	ros	134-137	amyloid beta precursor protein	Homo sapiens	37-42
20600834-9	2010	Human prostate and prostate cancer tissues showed an abundant presence of glut-p53 in luminal epithelium, a site well known to generate ROS.	ros	136-139	tumor protein p53	Homo sapiens	79-82
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	ros	120-123	mitogen-activated protein kinase 1	Homo sapiens	148-151
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	ros	120-123	mitogen-activated protein kinase 14	Homo sapiens	184-187
20716293-1	2010	The enzyme catalase converts solar radiation into reactive oxidant species (ROS).	ros	76-79	catalase	Homo sapiens	11-19
20434540-5	2010	Src kinase is also involved in the regulation of localized ROS production at invadopodia and podosomes, subcellular adhesion structures associated with extracellular matrix degradation, through spatially restricted activation of NADPH oxidase.	ros	59-62	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	0-3
20691059-7	2010	Further evidence is presented that synoviocyte responses to ROS and TRPV1 activation include increases in TNFalpha and COX-2, both measured as an indicator of the inflammation in vitro.	ros	60-63	tumor necrosis factor	Homo sapiens	106-114
20691059-7	2010	Further evidence is presented that synoviocyte responses to ROS and TRPV1 activation include increases in TNFalpha and COX-2, both measured as an indicator of the inflammation in vitro.	ros	60-63	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	119-124
20729567-3	2010	The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.	ros	15-18	tumor protein p53	Homo sapiens	37-40
20729567-3	2010	The control of ROS and senescence by p53 may help to explain how p53 can function to both restrain and promote aging.	ros	15-18	tumor protein p53	Homo sapiens	65-68
20716276-5	2010	We have recently reported that ROS and RNS can regulate Bcl-2 expression levels, thereby impacting its function.	ros	31-34	BCL2 apoptosis regulator	Homo sapiens	56-61
20716293-8	2010	Conformational changes following absorption of UVB light by catalase NADPH have the potential to facilitate ROS production by the enzyme.	ros	108-111	catalase	Homo sapiens	60-68
20512627-10	2010	The ROS scavenger NAC efficiently suppressed not only ROS generation, but also caspase-3-mediated PARP cleavage, apoptosis, and release of cytochrome c and AIF, indicating a role of ROS in combined Dox + DMPS treatment-induced apoptotic death signaling.	ros	4-7	caspase 3	Homo sapiens	79-88
20630072-4	2010	RESULTS: The profound control of AuNPs over the anti oxidant enzymes such as GSH, SOD, Catalase and GPx in diabetic mice to normal, by inhibition of lipid peroxidation and ROS generation during hyperglycemia evidence their anti-oxidant effect during hyperglycemia.	ros	172-175	catalase	Mus musculus	87-95
20512627-10	2010	The ROS scavenger NAC efficiently suppressed not only ROS generation, but also caspase-3-mediated PARP cleavage, apoptosis, and release of cytochrome c and AIF, indicating a role of ROS in combined Dox + DMPS treatment-induced apoptotic death signaling.	ros	4-7	cytochrome c, somatic	Homo sapiens	139-151
20399918-5	2010	We demonstrated that treatment of ROS 17/2.8 cells with AICAR and metformin stimulates Thr-172 phosphorylation of AMPK and dose-dependently increases its activity.	ros	34-37	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	114-118
20399918-6	2010	In contrast, treatment of ROS 17/2.8 cells with compound C inhibited AMPK phosphorylation.	ros	26-29	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	69-73
19937041-7	2010	Chlorogenic acid also suppressed the IL-1beta-induced production of ROS.	ros	68-71	interleukin 1 beta	Homo sapiens	37-45
21132068-4	2010	In contrast, the addition of HMG sensitizes LNCaP or PC3 prostate cancer cells harboring an active Akt to apoptosis, in which ROS is upregulated to induce the UPR and GADD153 expression.	ros	126-129	AKT serine/threonine kinase 1	Homo sapiens	99-102
21132068-4	2010	In contrast, the addition of HMG sensitizes LNCaP or PC3 prostate cancer cells harboring an active Akt to apoptosis, in which ROS is upregulated to induce the UPR and GADD153 expression.	ros	126-129	DNA damage inducible transcript 3	Homo sapiens	167-174
20430109-0	2010	Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells.	ros	67-70	mitogen-activated protein kinase 1	Homo sapiens	85-88
20430109-0	2010	Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells.	ros	67-70	mitogen-activated protein kinase 14	Homo sapiens	89-92
20430109-0	2010	Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells.	ros	67-70	mitogen-activated protein kinase 1	Homo sapiens	93-97
20599757-11	2010	It is suggested that Na(+) binding in renal ASCT2 may be regulated by ROS in SHR PTE cells.	ros	70-73	solute carrier family 1 member 5	Rattus norvegicus	44-49
20398749-6	2010	Moreover, pretreatment with the ROS scavenger N-acetylcysteine abolishes flavokawain B-induced ROS generation, GADD153 up-regulation, and apoptosis.	ros	32-35	DNA damage inducible transcript 3	Homo sapiens	111-118
20495454-6	2010	ROS are involved both in insulin signal transduction and in insulin resistance when produced in excess.	ros	0-3	insulin	Homo sapiens	25-32
20495454-6	2010	ROS are involved both in insulin signal transduction and in insulin resistance when produced in excess.	ros	0-3	insulin	Homo sapiens	60-67
20204677-5	2010	We found that TGF-beta1 activates NFkappaB, through Rac1-NOXs-ROS-dependent mechanism.	ros	62-65	transforming growth factor beta 1	Homo sapiens	14-23
20204677-5	2010	We found that TGF-beta1 activates NFkappaB, through Rac1-NOXs-ROS-dependent mechanism.	ros	62-65	nuclear factor kappa B subunit 1	Homo sapiens	34-42
20204677-0	2010	ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion.	ros	0-3	nuclear factor kappa B subunit 1	Homo sapiens	4-12
20204677-0	2010	ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion.	ros	0-3	transforming growth factor beta 1	Homo sapiens	22-31
20204677-6	2010	Our results shows that TGF-beta1 stimulation of uPA and MMP-9 expression involve NOXs-dependent ROS and NFkappaB, activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor.	ros	96-99	transforming growth factor beta 1	Homo sapiens	23-32
20204677-0	2010	ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion.	ros	0-3	plasminogen activator, urokinase	Homo sapiens	54-90
20204677-4	2010	In the present study, we analyzed the role of ROS-NFkappaB, signal as mediator in the cell malignity enhancement by TGF-beta1.	ros	46-49	nuclear factor kappa B subunit 1	Homo sapiens	50-58
20204677-4	2010	In the present study, we analyzed the role of ROS-NFkappaB, signal as mediator in the cell malignity enhancement by TGF-beta1.	ros	46-49	transforming growth factor beta 1	Homo sapiens	116-125
20204677-6	2010	Our results shows that TGF-beta1 stimulation of uPA and MMP-9 expression involve NOXs-dependent ROS and NFkappaB, activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor.	ros	96-99	plasminogen activator, urokinase	Homo sapiens	48-51
20204677-6	2010	Our results shows that TGF-beta1 stimulation of uPA and MMP-9 expression involve NOXs-dependent ROS and NFkappaB, activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor.	ros	169-172	transforming growth factor beta 1	Homo sapiens	23-32
20204677-6	2010	Our results shows that TGF-beta1 stimulation of uPA and MMP-9 expression involve NOXs-dependent ROS and NFkappaB, activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor.	ros	169-172	plasminogen activator, urokinase	Homo sapiens	48-51
20204677-7	2010	Furthermore, we found that the inhibition of ROS and NFkappaB, abrogates TGF-beta1 stimulation of EMT, cell motility and invasion.	ros	45-48	transforming growth factor beta 1	Homo sapiens	73-82
20204677-8	2010	Thus, ROS-NFkappaB acts as the crucial signal in TGF-beta1-induced uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1.	ros	6-9	nuclear factor kappa B subunit 1	Homo sapiens	10-18
20204677-8	2010	Thus, ROS-NFkappaB acts as the crucial signal in TGF-beta1-induced uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1.	ros	6-9	transforming growth factor beta 1	Homo sapiens	49-58
20204677-8	2010	Thus, ROS-NFkappaB acts as the crucial signal in TGF-beta1-induced uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1.	ros	6-9	plasminogen activator, urokinase	Homo sapiens	67-70
20204677-8	2010	Thus, ROS-NFkappaB acts as the crucial signal in TGF-beta1-induced uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1.	ros	6-9	transforming growth factor beta 1	Homo sapiens	151-160
19700217-5	2010	The release of calcium triggered the production of ROS, which further enhances calcium overloading and subsequently activates p38, JNK and ERK1/2.	ros	51-54	mitogen-activated protein kinase 1	Homo sapiens	126-129
21137371-13	2010	CONCLUSION: Above 15 micromol/L, 3"-meisoindigo can inhibit the proliferation and externalization function of thymocyte and splenocyte from different germ line mouse, meanwhile the mRNA and protein level of Bcl-2 and CDK2 decrease, the Bax protein expressed increased, the intracellular ROS level increase too.	ros	287-290	B cell leukemia/lymphoma 2	Mus musculus	207-212
20347035-6	2010	NOX1 was determined to be crucial for enhanced ROS production in intermittent hypoxia that in turn mediated induction of Nrf2 and Trx1.	ros	47-50	NFE2 like bZIP transcription factor 2	Homo sapiens	121-125
20145198-6	2010	Moreover, the addition of NAC, a scavenger of ROS, abrogated the rVpr-induced formation of OxPC, the phosphorylation of C/EBP-beta, a substrate of MAPK, and IL-6 production.	ros	46-49	interleukin 6	Homo sapiens	157-161
20510882-2	2010	In the present study, we found that protopanaxatriol ginsenoside Rh1 suppresses NO, ROS, and TNF-alpha production in IFN-gamma-stimulated BV2 microglial cells.	ros	84-87	interferon gamma	Mus musculus	117-126
20203069-9	2010	These data suggest that EGCG inhibits the oxLDL-induced LOX-1-mediated signaling pathway, at least in part, by inhibiting NADPH oxidase and consequent ROS-enhanced LOX-1 expression, which contributes to further ROS generation and the subsequent activation of NF-kappaB via the p38 MAPK pathway.	ros	151-154	nuclear factor kappa B subunit 1	Homo sapiens	259-268
20203069-9	2010	These data suggest that EGCG inhibits the oxLDL-induced LOX-1-mediated signaling pathway, at least in part, by inhibiting NADPH oxidase and consequent ROS-enhanced LOX-1 expression, which contributes to further ROS generation and the subsequent activation of NF-kappaB via the p38 MAPK pathway.	ros	151-154	mitogen-activated protein kinase 14	Homo sapiens	277-280
19700217-5	2010	The release of calcium triggered the production of ROS, which further enhances calcium overloading and subsequently activates p38, JNK and ERK1/2.	ros	51-54	mitogen-activated protein kinase 8	Homo sapiens	131-134
19700217-5	2010	The release of calcium triggered the production of ROS, which further enhances calcium overloading and subsequently activates p38, JNK and ERK1/2.	ros	51-54	mitogen-activated protein kinase 3	Homo sapiens	139-145
20230789-0	2010	Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation.	ros	90-93	mitogen-activated protein kinase 1	Mus musculus	61-64
20200474-1	2010	Anticancer effects of beta-lapachone (beta-lap) are due to generation of ROS and metabolic catastrophes as a result of NAD(P)H:quinone oxidoreductase (NQO1)-mediated futile cycling between the oxidized and reduced forms of beta-lap.	ros	73-76	NAD(P)H quinone dehydrogenase 1	Homo sapiens	151-155
20188821-8	2010	These results demonstrate that CSPE-induced ROS generation is mediated through a c-Src/NADPH oxidase/MAPK pathway and in turn initiates the activation of Nrf2 and ultimately induces HO-1 expression in HTSMCs.	ros	44-47	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	81-86
20188821-8	2010	These results demonstrate that CSPE-induced ROS generation is mediated through a c-Src/NADPH oxidase/MAPK pathway and in turn initiates the activation of Nrf2 and ultimately induces HO-1 expression in HTSMCs.	ros	44-47	NFE2 like bZIP transcription factor 2	Homo sapiens	154-158
20156602-6	2010	Furthermore, BAI potently inhibits the TNF-alpha-induced increase in ROS generation in A549 cells, suggesting that inhibition of ROS generation is maybe involved in the BAI-mediated inhibition of TNF-alpha-induced ICAM-1 down-regulation to A549 cells.	ros	69-72	tumor necrosis factor	Homo sapiens	39-48
20156602-6	2010	Furthermore, BAI potently inhibits the TNF-alpha-induced increase in ROS generation in A549 cells, suggesting that inhibition of ROS generation is maybe involved in the BAI-mediated inhibition of TNF-alpha-induced ICAM-1 down-regulation to A549 cells.	ros	69-72	tumor necrosis factor	Homo sapiens	196-205
20156602-6	2010	Furthermore, BAI potently inhibits the TNF-alpha-induced increase in ROS generation in A549 cells, suggesting that inhibition of ROS generation is maybe involved in the BAI-mediated inhibition of TNF-alpha-induced ICAM-1 down-regulation to A549 cells.	ros	129-132	tumor necrosis factor	Homo sapiens	39-48
20156602-6	2010	Furthermore, BAI potently inhibits the TNF-alpha-induced increase in ROS generation in A549 cells, suggesting that inhibition of ROS generation is maybe involved in the BAI-mediated inhibition of TNF-alpha-induced ICAM-1 down-regulation to A549 cells.	ros	129-132	tumor necrosis factor	Homo sapiens	196-205
20116857-6	2010	Significant production of ROS was observed only in the presence of Fc-OH-TAM in both ERalpha positive and negative breast cancer cell lines.	ros	26-29	estrogen receptor 1	Homo sapiens	85-92
20339118-11	2010	Nox5 activation by Ang II and ET-1 induces ROS generation and ERK1/2 phosphorylation.	ros	43-46	angiotensinogen	Homo sapiens	19-25
19912993-6	2010	The intracellular location of Nur77 was also associated with the differential capability of fenretinide-induced ROS generation in these two cell lines.	ros	112-115	nuclear receptor subfamily 4 group A member 1	Homo sapiens	30-35
20368800-0	2010	Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase.	ros	84-87	NLR family pyrin domain containing 3	Homo sapiens	37-42
20368800-6	2010	The ability of Aspergillus hyphae to activate the NLRP3 inflammasome in the monocytes requires K(+) efflux and ROS production.	ros	111-114	NLR family pyrin domain containing 3	Homo sapiens	50-55
20368806-0	2010	Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation.	ros	83-86	mitogen-activated protein kinase 1	Homo sapiens	97-100
20368806-0	2010	Simultaneous induction of non-canonical autophagy and apoptosis in cancer cells by ROS-dependent ERK and JNK activation.	ros	83-86	mitogen-activated protein kinase 8	Homo sapiens	105-108
20368806-11	2010	CONCLUSIONS/SIGNIFICANCE: Considering that loss of tumor suppressor beclin 1 is associated with neoplasia, the ability of this small molecule compound to engage both autophagic and apoptotic machineries via ROS production and subsequent activation of ERK and JNK could have potential translational implications.	ros	207-210	mitogen-activated protein kinase 1	Homo sapiens	251-254
20368806-11	2010	CONCLUSIONS/SIGNIFICANCE: Considering that loss of tumor suppressor beclin 1 is associated with neoplasia, the ability of this small molecule compound to engage both autophagic and apoptotic machineries via ROS production and subsequent activation of ERK and JNK could have potential translational implications.	ros	207-210	mitogen-activated protein kinase 8	Homo sapiens	259-262
20167927-10	2010	CONCLUSIONS: We conclude that AMPKalpha2 functions as a physiological suppressor of NAD(P)H oxidase and ROS production in endothelial cells.	ros	104-107	protein kinase, AMP-activated, alpha 2 catalytic subunit	Mus musculus	30-40
20015941-1	2010	Advanced glycation end products (AGEs) and the receptor for AGEs (RAGE) generate ROS, and therefore this study evaluated the effects of RAGE deletion, decreasing AGE accumulation, or lowering dietary AGE content on oxidative parameters in diabetic nephropathy (DN).	ros	81-84	advanced glycosylation end product-specific receptor	Mus musculus	66-70
20043934-6	2010	The MT-1a and 1b synthesized by zinc (also evidenced through RT-PCR experiments) is possibly able to scavenge ROS which is one of the early signaling molecules that lead to apoptosis.	ros	110-113	metallothionein 1A	Homo sapiens	4-16
20351780-3	2010	Selective loss or blockade of cytosolic Hsp60 by specific antisense oligonucleotide or neutralizing antibody diminished the IKK/NF-kappaB activation and the expression of NF-kappaB target genes, such as Bfl-1/A1 and MnSOD, which thus augmented intracellular ROS production and ASK1-dependent cell death, in response to TNF-alpha.	ros	258-261	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	171-180
20215861-3	2010	We also found that AnnAt1 is able to regulate accumulation of H(2)O(2) in vivo in Arabidopsis cells based on the observation that the level of ROS accumulation following induction by ABA correlates with the level of AnnAt1 protein in transgenic Arabidopsis plants.	ros	143-146	annexin 1	Arabidopsis thaliana	19-25
20201014-4	2010	Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.	ros	29-32	NLR family pyrin domain containing 3	Homo sapiens	49-54
20201014-4	2010	Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.	ros	29-32	NLR family pyrin domain containing 3	Homo sapiens	55-60
20201014-4	2010	Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.	ros	29-32	NLR family pyrin domain containing 3	Homo sapiens	121-126
20201014-4	2010	Recent findings suggest that ROS are produced by NLRP3/NALP3 activators and are essential secondary messengers signaling NLRP3/NALP3 inflammasome activation.	ros	29-32	NLR family pyrin domain containing 3	Homo sapiens	127-132
20034965-10	2010	Mutant analysis showed that, under prolonged darkness conditions, AtPIP1;2 can contribute to up to approximately 20% of K(ros) and to the osmotic water permeability of isolated mesophyll protoplasts.	ros	122-125	plasma membrane intrinsic protein 1B	Arabidopsis thaliana	66-74
20044444-13	2010	The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling.	ros	85-88	angiotensinogen	Rattus norvegicus	4-10
20044444-13	2010	The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling.	ros	85-88	potassium voltage-gated channel subfamily D member 3	Rattus norvegicus	33-38
20044444-13	2010	The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling.	ros	85-88	angiotensinogen	Rattus norvegicus	71-77
20005303-5	2010	In human PMNs, HMR concentration-dependently reduced ROS production induced by either N-formyl-Met-Leu-Phe, phorbol myristate acetate or angiotensin II, as well as interleukin-8 production induced by either N-formyl-Met-Leu-Phe or angiotensin II.	ros	53-56	angiotensinogen	Homo sapiens	137-151
20102164-5	2010	The title method was applied to the detection of endogenously produced ROS/RNS by single IFN-gamma/LPS/PMA stimulated RAW 264.7 macrophages.	ros	71-74	interferon gamma	Homo sapiens	89-98
19646807-0	2010	The pharmacological NFkappaB inhibitors BAY117082 and MG132 induce cell arrest and apoptosis in leukemia cells through ROS-mitochondria pathway activation.	ros	119-122	nuclear factor kappa B subunit 1	Homo sapiens	20-28
19815061-6	2010	With the generation of ROS, the increased activity of caspase-3 was shown, and was followed by chromatin condensation and breakage, which is an indication of the cellular apoptotic process.	ros	23-26	caspase 3	Homo sapiens	54-63
19815061-7	2010	ROS also triggered pro-inflammatory responses in cultured T98G cells, which were demonstrated by the increased gene expression and protein levels of IL-6 and IL-8.	ros	0-3	interleukin 6	Homo sapiens	149-153
19815061-7	2010	ROS also triggered pro-inflammatory responses in cultured T98G cells, which were demonstrated by the increased gene expression and protein levels of IL-6 and IL-8.	ros	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	158-162
19932078-2	2010	We demonstrate that reactive oxygen/nitrogen species (ROS/RNS) dose-dependently regulate iNOS function.	ros	54-57	nitric oxide synthase 2	Homo sapiens	89-93
19932078-3	2010	Tetrahydrobiopterin (BH4)-replete iNOS was exposed to increasing concentrations of ROS/RNS and activity was measured with and without subsequent BH4 addition.	ros	83-86	nitric oxide synthase 2	Homo sapiens	34-38
19932078-9	2010	In contrast to the inhibition of NO generation, ROS enhanced O2(.-) production from iNOS, while ONOO(-) had the opposite effect.	ros	48-51	nitric oxide synthase 2	Homo sapiens	84-88
19932078-10	2010	Thus, ROS promote reversible iNOS uncoupling, while ONOO(-) induces irreversible enzyme inactivation and decreases both NO and O2(.-) production.	ros	6-9	nitric oxide synthase 2	Homo sapiens	29-33
19905990-3	2010	Cytochrome P450 (Cyp) 4a14 has an important role in the metabolism of lipids and as a source of ROS in oxidative stress.	ros	96-99	cytochrome P450, family 4, subfamily a, polypeptide 14	Mus musculus	0-26
20498758-12	2010	Furthermore, early introduction of these two Runx2 and MEF factors significantly elevated the expression of the Opn mRNA levels in ROS cells.	ros	131-134	RUNX family transcription factor 2	Rattus norvegicus	45-50
20498758-12	2010	Furthermore, early introduction of these two Runx2 and MEF factors significantly elevated the expression of the Opn mRNA levels in ROS cells.	ros	131-134	enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase	Rattus norvegicus	55-58
20018174-4	2010	Intracellular ROS was measured in THBP transfected cells using DCF fluorescence.	ros	14-17	crystallin mu	Homo sapiens	34-38
20093775-9	2010	IL-10 from cDCs reduced production of TNF, IL-6, and ROS by inflammatory monocytes.	ros	53-56	interleukin 10	Mus musculus	0-5
20018174-8	2010	The expression of THBP as a fusion protein in transfected HMCs resulted in reduction of glucose-induced intracellular ROS.	ros	118-121	crystallin mu	Homo sapiens	18-22
20018174-9	2010	We have shown that THBP mRNA is increased in diabetic kidney and heart, is regulated by high glucose in renal cells, and appears to attenuate glucose-induced intracellular ROS.	ros	172-175	crystallin mu	Homo sapiens	19-23
19892012-11	2010	These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.	ros	43-46	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	100-105
20129243-4	2010	Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth.	ros	47-50	sirtuin 3	Homo sapiens	8-13
19892012-11	2010	These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.	ros	43-46	nuclear factor kappa B subunit 1	Homo sapiens	175-184
19892012-11	2010	These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.	ros	43-46	prostaglandin-endoperoxide synthase 2	Homo sapiens	209-214
19892012-11	2010	These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.	ros	43-46	interleukin 6	Homo sapiens	222-226
21060899-9	2010	Our results indicate that in Cu,Zn-SOD-deficient animals the level of oxidative DNA damage and NF-kappaB1 activity are elevated in certain organs only, which may provide some explanation for organ-specific ROS-induced carcinogenesis.	ros	206-209	superoxide dismutase 1, soluble	Mus musculus	29-38
21060899-9	2010	Our results indicate that in Cu,Zn-SOD-deficient animals the level of oxidative DNA damage and NF-kappaB1 activity are elevated in certain organs only, which may provide some explanation for organ-specific ROS-induced carcinogenesis.	ros	206-209	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-105
20503474-4	2010	Pretreatment with ABO also blocked TNF-alpha-induced ROS formation.	ros	53-56	tumor necrosis factor	Homo sapiens	35-44
19874289-3	2010	Since insulin-like growth factor-1 (IGF-1) interferes with a cell"s apoptotic machinery when subjected to several stressful conditions, it is demonstrated here for the first time that IGF-1 effectively protects lymphocytes against rotenone through PI-3K/Akt activation, down-regulation of p53 and maintenance of mitochondrial membrane potential independently of ROS generation.	ros	362-365	insulin like growth factor 1	Homo sapiens	6-34
19874289-3	2010	Since insulin-like growth factor-1 (IGF-1) interferes with a cell"s apoptotic machinery when subjected to several stressful conditions, it is demonstrated here for the first time that IGF-1 effectively protects lymphocytes against rotenone through PI-3K/Akt activation, down-regulation of p53 and maintenance of mitochondrial membrane potential independently of ROS generation.	ros	362-365	insulin like growth factor 1	Homo sapiens	36-41
19874289-3	2010	Since insulin-like growth factor-1 (IGF-1) interferes with a cell"s apoptotic machinery when subjected to several stressful conditions, it is demonstrated here for the first time that IGF-1 effectively protects lymphocytes against rotenone through PI-3K/Akt activation, down-regulation of p53 and maintenance of mitochondrial membrane potential independently of ROS generation.	ros	362-365	insulin like growth factor 1	Homo sapiens	184-189
19896462-5	2010	TNF-alpha-induced intracellular ROS was markedly decreased by pretreatment with BA.	ros	32-35	tumor necrosis factor	Homo sapiens	0-9
20460761-6	2010	Taken together, these results suggest that Sch B-induced glutathione antioxidant response and cardioprotection may be mediated by ROS arising from CYP-catalyzed reaction.	ros	130-133	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	147-150
20460761-1	2010	To investigate the involvement of reactive oxidant species (ROS), presumably arising from cytochrome P-450 (CYP)-catalyzed metabolism of schisandrin B (Sch B), in triggering glutathione antioxidant response, Sch B induced reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent and CYP-catalyzed reaction and associated ROS production were examined in rat heart microsomes.	ros	60-63	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	90-106
20460761-1	2010	To investigate the involvement of reactive oxidant species (ROS), presumably arising from cytochrome P-450 (CYP)-catalyzed metabolism of schisandrin B (Sch B), in triggering glutathione antioxidant response, Sch B induced reduced nicotinamide adenine dinucleotide phosphate (NADPH)-dependent and CYP-catalyzed reaction and associated ROS production were examined in rat heart microsomes.	ros	60-63	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	108-111
20360613-7	2010	Studies have shown that p38MAP kinase, nuclear factor kappaB (NF-kappaB), PKC/ERK and JNK/c-Jun all take part in the ROS-activated production of ET-1.	ros	117-120	mitogen-activated protein kinase 14	Homo sapiens	24-37
19956840-4	2010	We further found that inhibition of ERK1/2 by U0126 abolished the effects of hypoxia to switch the cell death mode and to suppress mitochondrial ROS production, indicating an important role(s) of the ERK pathway in cell death mode determination.	ros	145-148	mitogen-activated protein kinase 3	Homo sapiens	36-42
19956840-4	2010	We further found that inhibition of ERK1/2 by U0126 abolished the effects of hypoxia to switch the cell death mode and to suppress mitochondrial ROS production, indicating an important role(s) of the ERK pathway in cell death mode determination.	ros	145-148	mitogen-activated protein kinase 3	Homo sapiens	36-39
19780038-4	2010	Notexin-induced cell death, mitochondrial depolarization, and ROS generation were suppressed by SB202190 (p38 MAPK inhibitor) and SP600125 (JNK inhibitor).	ros	62-65	mitogen-activated protein kinase 14	Homo sapiens	106-109
19780038-4	2010	Notexin-induced cell death, mitochondrial depolarization, and ROS generation were suppressed by SB202190 (p38 MAPK inhibitor) and SP600125 (JNK inhibitor).	ros	62-65	mitogen-activated protein kinase 8	Homo sapiens	140-143
19955654-0	2010	Urea-induced ROS generation causes insulin resistance in mice with chronic renal failure.	ros	13-16	insulin	Homo sapiens	35-42
19955654-2	2010	We previously demonstrated that ROS increase intracellular protein modification by O-linked beta-N-acetylglucosamine (O-GlcNAc), and others showed that increased modification of insulin signaling molecules by O-GlcNAc reduces insulin signal transduction.	ros	32-35	insulin	Homo sapiens	178-185
19955654-2	2010	We previously demonstrated that ROS increase intracellular protein modification by O-linked beta-N-acetylglucosamine (O-GlcNAc), and others showed that increased modification of insulin signaling molecules by O-GlcNAc reduces insulin signal transduction.	ros	32-35	insulin	Homo sapiens	226-233
20816008-2	2010	The studies in our laboratory have clearly demonstrated that idarubicin can undergo reductive bioactivation by NADPH-cytochrome P450 reductase to free radicals with resulting formation of DNA strand breaks, which can potentially contribute to its genotoxic effects [Celik, H., Arinc, E., Bioreduction of idarubicin and formation of ROS responsible for DNA cleavage by NADPH-cytochrome P450 reductase and its potential role in the antitumor effect.	ros	332-335	cytochrome p450 oxidoreductase	Homo sapiens	111-142
20402656-10	2010	ERK activation was inhibited by PD98059, Wortmanin and the ROS scavenger NAC (N-acetyl cysteine).	ros	59-62	mitogen-activated protein kinase 1	Homo sapiens	0-3
19939451-4	2010	Especially, Rac-associated ROS-dependent MAP kinases, including ERK1/2 and p38, are involved in MHC class II-associated negative signal transduction in the phorbol 12, 13-dibutyrate (PDBU)-treated, but not LPS-treated, resting B cell line, 38B9.	ros	27-30	AKT serine/threonine kinase 1	Homo sapiens	12-15
19939451-4	2010	Especially, Rac-associated ROS-dependent MAP kinases, including ERK1/2 and p38, are involved in MHC class II-associated negative signal transduction in the phorbol 12, 13-dibutyrate (PDBU)-treated, but not LPS-treated, resting B cell line, 38B9.	ros	27-30	mitogen-activated protein kinase 3	Homo sapiens	64-70
19939451-4	2010	Especially, Rac-associated ROS-dependent MAP kinases, including ERK1/2 and p38, are involved in MHC class II-associated negative signal transduction in the phorbol 12, 13-dibutyrate (PDBU)-treated, but not LPS-treated, resting B cell line, 38B9.	ros	27-30	mitogen-activated protein kinase 1	Homo sapiens	75-78
19939451-7	2010	Collectively, Rac/ROS-related PKC and PI3K signaling are involved in a negative regulation cascade through the cross-linking of MHC class II molecules by anti-MHC class II antibodies in resting B cells.	ros	18-21	AKT serine/threonine kinase 1	Homo sapiens	14-17
19853624-5	2010	The presented evidence supports the conclusion that AMPK activated by AICAR is involved in regulation of ROS and cytokine production (IL-1 beta, TNF-alpha (6h), IL-10 and TGF-beta) as well as arginase I and PGC-1alpha expression.	ros	105-108	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	52-56
20360613-7	2010	Studies have shown that p38MAP kinase, nuclear factor kappaB (NF-kappaB), PKC/ERK and JNK/c-Jun all take part in the ROS-activated production of ET-1.	ros	117-120	mitogen-activated protein kinase 1	Homo sapiens	78-81
20360613-7	2010	Studies have shown that p38MAP kinase, nuclear factor kappaB (NF-kappaB), PKC/ERK and JNK/c-Jun all take part in the ROS-activated production of ET-1.	ros	117-120	mitogen-activated protein kinase 8	Homo sapiens	86-89
20360613-7	2010	Studies have shown that p38MAP kinase, nuclear factor kappaB (NF-kappaB), PKC/ERK and JNK/c-Jun all take part in the ROS-activated production of ET-1.	ros	117-120	endothelin 1	Homo sapiens	145-149
20596957-0	2010	Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK.	ros	96-99	NPHS2 stomatin family member, podocin	Rattus norvegicus	71-78
20193368-6	2009	RESULTS: TNF-alpha stimulation caused ROS output increased by 155% of control (228 +/- 51 vs 89 +/- 24, P &lt; 0.05); alpha-zearalanol was able to reduce the production of ROS in a dose-dependent manner.	ros	38-41	tumor necrosis factor	Homo sapiens	9-18
20052342-8	2010	Expression of eNOS RNA was unchanged, whereas NOx level and phosphorylated-eNOS at serine-1177 was increased accompanied with depressed level of caveolin-1 in ROS.	ros	159-162	caveolin 1	Rattus norvegicus	145-155
19720122-0	2009	Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway.	ros	89-92	mitogen-activated protein kinase 1	Homo sapiens	117-120
19720122-0	2009	Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway.	ros	89-92	mitogen-activated protein kinase 14	Homo sapiens	153-156
19720122-9	2009	Taken together, our data indicate that Fas/FasL upregulation in AA-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas-mediated apoptotoic mechanism is involved in AA-induced cell death.	ros	108-111	mitogen-activated protein kinase 1	Homo sapiens	136-139
19720122-9	2009	Taken together, our data indicate that Fas/FasL upregulation in AA-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas-mediated apoptotoic mechanism is involved in AA-induced cell death.	ros	108-111	mitogen-activated protein kinase 14	Homo sapiens	172-175
20193368-6	2009	RESULTS: TNF-alpha stimulation caused ROS output increased by 155% of control (228 +/- 51 vs 89 +/- 24, P &lt; 0.05); alpha-zearalanol was able to reduce the production of ROS in a dose-dependent manner.	ros	172-175	tumor necrosis factor	Homo sapiens	9-18
20193368-10	2009	CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase.	ros	12-15	tumor necrosis factor	Homo sapiens	61-70
20193368-10	2009	CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase.	ros	12-15	tumor necrosis factor	Homo sapiens	193-202
20193368-10	2009	CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase.	ros	254-257	tumor necrosis factor	Homo sapiens	61-70
20193368-10	2009	CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase.	ros	254-257	tumor necrosis factor	Homo sapiens	193-202
20032403-0	2009	Catalase protects tumor cells from apoptosis induction by intercellular ROS signaling.	ros	72-75	catalase	Homo sapiens	0-8
19904588-3	2009	The respiratory depression, which was due to loss of mitochondrial cytochrome c, was associated with decreased capacity of respiratory chain oxidative phosphorylation and enhanced cellular level of ROS.	ros	198-201	cytochrome c, somatic	Homo sapiens	67-79
19877015-8	2009	ROS-dependent regulation of BCR-induced proliferation may help modulate the size of the humoral response to T-cell-independent type 2 Ag immunization.	ros	0-3	BCR activator of RhoGEF and GTPase	Mus musculus	28-31
19837945-2	2009	PTH(1-34) increased total PLD activity by 3-fold in CHO-R3 cells and by 2-fold in ROS cells.	ros	82-85	parathyroid hormone	Homo sapiens	0-3
19837945-5	2009	However, only WT-PLD2 expression increased PTH-dependent PLD activity in ROS cells.	ros	73-76	parathyroid hormone	Homo sapiens	43-46
19837945-5	2009	However, only WT-PLD2 expression increased PTH-dependent PLD activity in ROS cells.	ros	73-76	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	17-20
20032403-5	2009	Resistance of tumor cells against intercellular ROS signaling depends on interference through catalase expression on the membrane.	ros	48-51	catalase	Homo sapiens	94-102
20032403-6	2009	Intercellular ROS signaling of tumor cells can be restored when i) exogenous HOCl is added; ii) exogenous hydrogen peroxide is supplied, or iii) catalase is inhibited.	ros	14-17	catalase	Homo sapiens	145-153
19585524-11	2009	Our results indicate a role for Ras and Rac in the induction of both intracellular ROS increased levels and apoptosis mediated by PFAs and disclose a new scenario of intervention in neurodegenerative diseases.	ros	83-86	thymoma viral proto-oncogene 1	Mus musculus	40-43
19577004-4	2009	Treatment of tissue cultures with ROS is known to induce MAPK activity.	ros	34-37	mitogen-activated protein kinase 3	Homo sapiens	57-61
19882753-4	2009	In wound-healing assays, decreased ROS in OLA1-knockdown cells were in situ associated with the cells" decreased motile morphology.	ros	35-38	Obg like ATPase 1	Homo sapiens	42-46
19882753-6	2009	These results suggest that knockdown of OLA1 inhibits breast cancer cell migration and invasion through a mechanism that involves the modulation of intracellular ROS levels.	ros	162-165	Obg like ATPase 1	Homo sapiens	40-44
19699263-4	2009	Abeta(25-35) significantly reduced cell viability, increased the number of apoptotic-like cells, and increased ROS production.	ros	111-114	amyloid beta precursor protein	Homo sapiens	0-5
19806015-0	2009	Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels.	ros	77-80	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
19561312-9	2009	Surprisingly, in in vitro experiments, treatment of PMNs with CORM-3 further augmented LPS/fMLP-induced ROS production and the release of elastase.	ros	104-107	formyl peptide receptor 1	Homo sapiens	91-95
19553562-3	2009	Overexpression of PGC-1alpha in cultured VSMCs led to a 74.5% reduction of migration activity and mitochondrial ROS generation by the increased expression of antioxidative proteins such as SOD-2 in the mitochondria.	ros	112-115	PPARG coactivator 1 alpha	Rattus norvegicus	18-28
19520779-8	2009	Preincubation with U18666A also decreased ACTH-induced seladin-1 and 11beta-hydroxylase protein expression as well as corticosterone production, increased ACTH-induced ROS production but decreased ACTH-induced expression of the detoxifying protein aldo-ketoreductase 1b7.	ros	168-171	proopiomelanocortin	Homo sapiens	42-46
19751401-7	2009	By using mice deficient in iNOS and phox47 and apocynin, we demonstrated that RNS and ROS are important to hemorrhage development after infection by DENV.	ros	86-89	nitric oxide synthase 2, inducible	Mus musculus	27-31
19501648-10	2009	Experiments are also presented showing that NA-Gly caused a respiration-dependent large ROS production, which seems in turn to be responsible for the inhibition of electron transport activity and cytochrome c release.	ros	88-91	cytochrome c, somatic	Homo sapiens	196-208
19520779-8	2009	Preincubation with U18666A also decreased ACTH-induced seladin-1 and 11beta-hydroxylase protein expression as well as corticosterone production, increased ACTH-induced ROS production but decreased ACTH-induced expression of the detoxifying protein aldo-ketoreductase 1b7.	ros	168-171	proopiomelanocortin	Homo sapiens	155-159
19520779-8	2009	Preincubation with U18666A also decreased ACTH-induced seladin-1 and 11beta-hydroxylase protein expression as well as corticosterone production, increased ACTH-induced ROS production but decreased ACTH-induced expression of the detoxifying protein aldo-ketoreductase 1b7.	ros	168-171	proopiomelanocortin	Homo sapiens	155-159
19482076-0	2009	ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.	ros	0-3	AKT serine/threonine kinase 1	Homo sapiens	11-14
19482076-5	2009	These observations implicate the direct interaction between Akt and ROS.	ros	68-71	AKT serine/threonine kinase 1	Homo sapiens	60-63
18544047-6	2009	Through suppressing the expression of another ERRalpha target gene pyruvate dehydrogenase kinase 2 (PDK2), we found that XCT-790 not only enhanced the conversion of pyruvate to acetyl-CoA and hyper-activated the tricarboxylic acid (TCA) cycle, but also led to higher levels of mitochondrial membrane potential and reactive oxidant species (ROS) production.	ros	340-343	estrogen related receptor alpha	Homo sapiens	46-54
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	ros	41-44	AKT serine/threonine kinase 1	Homo sapiens	51-54
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	ros	203-206	AKT serine/threonine kinase 1	Homo sapiens	51-54
19482076-8	2009	All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation.	ros	89-92	AKT serine/threonine kinase 1	Homo sapiens	127-130
19482076-8	2009	All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation.	ros	89-92	AKT serine/threonine kinase 1	Homo sapiens	197-200
19482076-8	2009	All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation.	ros	89-92	AKT serine/threonine kinase 1	Homo sapiens	197-200
19482076-8	2009	All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation.	ros	89-92	AKT serine/threonine kinase 1	Homo sapiens	197-200
19615399-3	2009	OBJECTIVE: We studied the role of protein kinase A (PKA), protein kinase B (Akt/PKB) and p38 mitogen-activated protein kinase (p38 MAPK) signaling pathways in ROS produced by neutrophils induced by pro-interferon-gamma (IFN-gamma) or anti-inflammatory interleukin 10 (IL-10) cytokines age-related.	ros	159-162	mitogen-activated protein kinase 14	Homo sapiens	89-125
19544385-6	2009	NVCMs infected with adenovirus expressing the L-arginine transporter, CAT1, and NVCMs supplemented with L-arginine both exhibited significant (all P &lt; 0.05) improvements in NO generation and mitochondrial membrane potentials, with a concomitant significant fall in ROS production and lactate dehydrogenase release during hypoxia-reoxygenation.	ros	268-271	transient receptor potential cation channel, subfamily V, member 6	Rattus norvegicus	70-74
19652361-6	2009	In primary cultures of cardiomyocytes, Sirt3 blocked cardiac hypertrophy by activating the forkhead box O3a-dependent (Foxo3a-dependent), antioxidant-encoding genes manganese superoxide dismutase (MnSOD) and catalase (Cat), thereby decreasing cellular levels of ROS.	ros	262-265	superoxide dismutase 2, mitochondrial	Mus musculus	197-202
19652361-7	2009	Reduced ROS levels suppressed Ras activation and downstream signaling through the MAPK/ERK and PI3K/Akt pathways.	ros	8-11	mitogen-activated protein kinase 1	Mus musculus	82-86
19652361-7	2009	Reduced ROS levels suppressed Ras activation and downstream signaling through the MAPK/ERK and PI3K/Akt pathways.	ros	8-11	mitogen-activated protein kinase 1	Mus musculus	87-90
19652361-7	2009	Reduced ROS levels suppressed Ras activation and downstream signaling through the MAPK/ERK and PI3K/Akt pathways.	ros	8-11	thymoma viral proto-oncogene 1	Mus musculus	100-103
19615399-3	2009	OBJECTIVE: We studied the role of protein kinase A (PKA), protein kinase B (Akt/PKB) and p38 mitogen-activated protein kinase (p38 MAPK) signaling pathways in ROS produced by neutrophils induced by pro-interferon-gamma (IFN-gamma) or anti-inflammatory interleukin 10 (IL-10) cytokines age-related.	ros	159-162	mitogen-activated protein kinase 14	Homo sapiens	127-135
19615399-6	2009	RESULTS: ROS production in human neutrophil was activated by IFN-gamma in all the groups studied.	ros	9-12	interferon gamma	Homo sapiens	61-70
19615399-12	2009	CONCLUSION: The results suggest that inhibitory effect of the ROS production mediated by IL-10 depends on PKA for the younger and the lack effect on the elderly is p38 MAPK dependent.	ros	62-65	mitogen-activated protein kinase 14	Homo sapiens	164-167
18767140-10	2009	Early-stage JNK activation is solely ROS-dependent, whereas late-stage activation is dependent on ROS-mediated caspase activity, and regulated by caspase-induced activation of PAK2.	ros	37-40	mitogen-activated protein kinase 8	Homo sapiens	12-15
18821261-1	2009	Catalase in albumin microspheres were formulated for intravenous administration to antagonize the effects of over-production of reactive oxygenated species (ROS) such as hydrogen peroxide (H(2)O(2)) in septic shock.	ros	157-160	catalase	Homo sapiens	0-8
19549533-8	2009	By contrast, treatment of CAECs with CR serum attenuated TNFalpha-induced ROS generation and prevented NF-kappaB activation and induction of inflammatory genes.	ros	74-77	tumor necrosis factor	Rattus norvegicus	57-65
19649246-2	2009	The proinflammatory cytokine TNFalpha primes ROS production through phosphorylation of the NADPH-oxidase subunit p47phox on Ser345.	ros	45-48	tumor necrosis factor	Rattus norvegicus	29-37
19649246-6	2009	METHODOLOGY AND PRINCIPAL FINDINGS: We analyzed the effect of punicic acid on TNFalpha-induced neutrophil upregulation of ROS production in vitro and on TNBS-induced rat colon inflammation.	ros	122-125	tumor necrosis factor	Rattus norvegicus	78-86
19649246-7	2009	Results show that punicic acid inhibited TNFalpha-induced priming of ROS production in vitro while preserving formyl-methionyl-leucyl-phenylalanine (fMLP)-induced response.	ros	69-72	tumor necrosis factor	Rattus norvegicus	41-49
19249354-3	2009	Microtubule disruption rapidly induced EGFR transactivation (at the src kinase-sensitive EGFR(Y845) site) in a ROS-dependent manner.	ros	111-114	epidermal growth factor receptor	Homo sapiens	39-43
19465002-0	2009	Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells.	ros	60-63	tumor necrosis factor	Homo sapiens	48-51
19465002-6	2009	Furthermore, TNF-induced ROS production in Gel(mut) cells was significantly decreased, demonstrating that gelsolin-mediated ROS generation plays a crucial role in TNF-induced apoptosis in MCF-7 cells.	ros	25-28	tumor necrosis factor	Homo sapiens	13-16
19465002-6	2009	Furthermore, TNF-induced ROS production in Gel(mut) cells was significantly decreased, demonstrating that gelsolin-mediated ROS generation plays a crucial role in TNF-induced apoptosis in MCF-7 cells.	ros	124-127	tumor necrosis factor	Homo sapiens	13-16
19465002-6	2009	Furthermore, TNF-induced ROS production in Gel(mut) cells was significantly decreased, demonstrating that gelsolin-mediated ROS generation plays a crucial role in TNF-induced apoptosis in MCF-7 cells.	ros	124-127	tumor necrosis factor	Homo sapiens	163-166
19465002-8	2009	Our study thus provides genetic evidence linking gelsolin-mediated ROS production to TNF-induced cell death.	ros	67-70	tumor necrosis factor	Homo sapiens	85-88
19364500-6	2009	Notably, levels of ROS were rapidly increased upon UV-irradiation and the ROS scavenger NAC inhibits UV-induced senescence of Akt1(-/-) MEFs, suggesting that UV light induces premature senescence in Akt1(-/-) MEFs by modulating intracellular levels of ROS.	ros	74-77	thymoma viral proto-oncogene 1	Mus musculus	126-130
19364500-6	2009	Notably, levels of ROS were rapidly increased upon UV-irradiation and the ROS scavenger NAC inhibits UV-induced senescence of Akt1(-/-) MEFs, suggesting that UV light induces premature senescence in Akt1(-/-) MEFs by modulating intracellular levels of ROS.	ros	74-77	thymoma viral proto-oncogene 1	Mus musculus	126-130
19460395-4	2009	Chlorpromazine, an inhibitor of melatonin-calmodulin interaction, inhibits both ROS and arachidonic acid production, thus possibly placing calmodulin at the origin of a melatonin-induced pro-radical pathway.	ros	80-83	calmodulin 1	Homo sapiens	42-52
19460395-4	2009	Chlorpromazine, an inhibitor of melatonin-calmodulin interaction, inhibits both ROS and arachidonic acid production, thus possibly placing calmodulin at the origin of a melatonin-induced pro-radical pathway.	ros	80-83	calmodulin 1	Homo sapiens	139-149
19558790-7	2009	The results indicated that the expressed non-glycosylated PrP in HeLa cells obviously induced apoptosis, inhibited the growth of cells and reduced the mitochondrial membrane potential, and more ROS generation and low levels of the apoptosis-related proteins Bcl-xL, the activated the cleaved Caspase-9 proteins were found.	ros	194-197	prion protein	Homo sapiens	58-61
19364500-0	2009	UV light induces premature senescence in Akt1-null mouse embryonic fibroblasts by increasing intracellular levels of ROS.	ros	117-120	thymoma viral proto-oncogene 1	Mus musculus	41-45
19364500-6	2009	Notably, levels of ROS were rapidly increased upon UV-irradiation and the ROS scavenger NAC inhibits UV-induced senescence of Akt1(-/-) MEFs, suggesting that UV light induces premature senescence in Akt1(-/-) MEFs by modulating intracellular levels of ROS.	ros	19-22	thymoma viral proto-oncogene 1	Mus musculus	199-203
19376252-6	2009	The results indicate that upstream ROS signals play a potential role in exogenous oxidative stress-induced cell death through mitochondrial dysfunction and cyt c release.	ros	35-38	cytochrome c, somatic	Homo sapiens	156-161
19249354-3	2009	Microtubule disruption rapidly induced EGFR transactivation (at the src kinase-sensitive EGFR(Y845) site) in a ROS-dependent manner.	ros	111-114	epidermal growth factor receptor	Homo sapiens	89-93
19249354-5	2009	MEK/ERK involvement downstream of ROS generation was critical for PAI-1, but not CTGF, expression following cytoskeletal perturbation suggesting bifurcation of signaling pathways downstream of EGFR activation.	ros	34-37	mitogen-activated protein kinase kinase 7	Homo sapiens	0-3
19249354-5	2009	MEK/ERK involvement downstream of ROS generation was critical for PAI-1, but not CTGF, expression following cytoskeletal perturbation suggesting bifurcation of signaling pathways downstream of EGFR activation.	ros	34-37	mitogen-activated protein kinase 1	Homo sapiens	4-7
19180563-0	2009	ROS-mediated p38alpha MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas-mediated cell death in Taiwan cobra phospholipase A(2)-treated U937 cells.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	13-21
19482643-5	2009	The ability of Bcl-2 to promote, modulate and optimize mitochondrial respiration under different redox states highlights the importance of mitochondrial bioenergetics, ROS and the roles they might play in the onset and/or maintenance of oncogenesis.	ros	168-171	BCL2 apoptosis regulator	Homo sapiens	15-20
19234337-12	2009	Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway.	ros	267-270	tumor necrosis factor	Homo sapiens	42-51
19180563-5	2009	Abolition of PLA(2)-induced ROS generation abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored ERK activation and viability of PLA(2)-treated cells.	ros	28-31	mitogen-activated protein kinase 14	Homo sapiens	53-56
19180563-11	2009	Taken together, our results indicate that Fas/FasL upregulation in PLA(2)-treated U937 cells is elicited by ROS-mediated p38alpha MAPK activation and ERK inactivation, and suggest that autocrine Fas/FasL apoptotic mechanism is involved in PLA(2)-induced cell death.	ros	108-111	mitogen-activated protein kinase 14	Homo sapiens	121-129
19366706-2	2009	Here we demonstrate that PLD-dependent generation of phosphatidic acid is critical for Rac1/IQGAP1 signal transduction, translocation of p47(phox) to cell periphery, and ROS production.	ros	170-173	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	25-28
19366706-6	2009	Conversely, overexpression of catalytically inactive mutants of PLD (hPLD1-K898R or mPLD2-K758R) or down-regulation of expression of PLD with PLD1 or PLD2 siRNA did not augment hyperoxia-induced [(32)P]phosphatidylbutanol accumulation and ROS generation.	ros	239-242	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	64-67
19366706-10	2009	These results demonstrate a role of PLD in hyperoxia-mediated IQGAP1 activation through Rac1 in tyrosine phosphorylation of Src and cortactin, as well as in p47(phox) translocation and ROS formation in human lung endothelial cells.	ros	185-188	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	36-39
19339551-7	2009	Additionally, a marked reduction in the level of channel alpha-subunit, guanylate cyclase I (GC1) and ATP-binding cassette transporter (ABCA4) was observed without affecting levels of other ROS proteins, consistent with a requirement for the beta-subunit in channel assembly or targeting of select proteins to ROS.	ros	310-313	olfactomedin 4	Homo sapiens	93-96
19337996-0	2009	IFN-gamma-STAT1 signal regulates the differentiation of inducible Treg: potential role for ROS-mediated apoptosis.	ros	91-94	interferon gamma	Mus musculus	0-9
19337996-7	2009	This inhibitory effect of IFN-gamma on iTreg generation was significantly abrogated after N-acetyl-L-cysteine treatment both in vitro and in vivo, indicating that IFN-gamma regulation of iTreg generation is dependent on ROS-mediated apoptosis.	ros	220-223	interferon gamma	Mus musculus	26-35
19337996-7	2009	This inhibitory effect of IFN-gamma on iTreg generation was significantly abrogated after N-acetyl-L-cysteine treatment both in vitro and in vivo, indicating that IFN-gamma regulation of iTreg generation is dependent on ROS-mediated apoptosis.	ros	220-223	interferon gamma	Mus musculus	163-172
19337996-8	2009	Therefore, our results suggest that autocrine IFN-gamma can negatively regulate the neo-generation of FOXP3(+) iTreg through ROS-mediated apoptosis in the periphery.	ros	125-128	interferon gamma	Mus musculus	46-55
19241442-5	2009	We also demonstrate that the amount of ROS is moderately increased in the cells ectopically expressing V12C40 and dramatically elevated by suppression of PKC, which leads to apoptosis through the activation of UPR.	ros	39-42	proline rich transmembrane protein 2	Homo sapiens	154-157
19427495-2	2009	There is evidence that hypertensive stimuli, such as high salt and angiotensin II, promote the production of ROS in the brain, the kidney, and the vasculature and that each of these sites contributes either to hypertension or to the untoward sequelae of this disease.	ros	109-112	angiotensinogen	Homo sapiens	67-81
19281832-5	2009	Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively.	ros	113-116	interleukin 1 beta	Homo sapiens	10-18
19281832-5	2009	Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively.	ros	113-116	nuclear factor kappa B subunit 1	Homo sapiens	30-39
19427492-3	2009	Insulin resistance is induced by activation of the RAAS and resulting increases in ROS.	ros	83-86	insulin	Homo sapiens	0-7
19427492-5	2009	Indeed, there is a mounting body of evidence that the resultant insulin resistance in cardiovascular tissue and kidneys contributes to the development of endothelial dysfunction, HTN, atherosclerosis, CKD, and CVD.77 RAAS-associated signaling by way of the AT1R and MR, triggers tissue activation of the NADPH oxidase enzymatic activation and increased production of ROS.	ros	367-370	insulin	Homo sapiens	64-71
19439215-6	2009	Importantly, we show that the two conserved cysteine residues of Bax seem to be critical for sensing the intracellular ROS to initiate Bax conformational changes and subsequent apoptosis.	ros	119-122	BCL2 associated X, apoptosis regulator	Homo sapiens	65-68
19439215-6	2009	Importantly, we show that the two conserved cysteine residues of Bax seem to be critical for sensing the intracellular ROS to initiate Bax conformational changes and subsequent apoptosis.	ros	119-122	BCL2 associated X, apoptosis regulator	Homo sapiens	135-138
19339551-7	2009	Additionally, a marked reduction in the level of channel alpha-subunit, guanylate cyclase I (GC1) and ATP-binding cassette transporter (ABCA4) was observed without affecting levels of other ROS proteins, consistent with a requirement for the beta-subunit in channel assembly or targeting of select proteins to ROS.	ros	310-313	ATP binding cassette subfamily A member 4	Homo sapiens	136-141
19245212-5	2009	These results indicate the advantages of combining an antioxidant nitroxide or nitroxide precursor with a PARP inhibitor molecule to decrease or eliminate the deleterious processes initiated by reactive oxygen and reactive nitrogen species (ROS and RNS).	ros	241-244	poly(ADP-ribose) polymerase 1	Homo sapiens	106-110
19407978-5	2009	These inhibitory actions of CLT were, at least in part, attributable to the inhibition of redox sensitive NF-kappaB activation, as CLT inhibited TNF-alpha-induced ROS generation as well as NF-kappaB nuclear translocation and activation in HT29 cells.	ros	163-166	tumor necrosis factor	Homo sapiens	145-154
19298665-0	2009	Ascorbic acid pre-treated quartz stimulates TNF-alpha release in RAW 264.7 murine macrophages through ROS production and membrane lipid peroxidation.	ros	102-105	tumor necrosis factor	Mus musculus	44-53
19298665-6	2009	RESULTS: Here we demonstrate that TNF-alpha mRNA synthesis and protein secretion are significantly increased in RAW 264.7 macrophages challenged with QA as compared to Q particles, and that the enhanced response is due to an increase of intracellular ROS.	ros	251-254	tumor necrosis factor	Mus musculus	34-43
18992805-6	2009	Interestingly, levels of UCP4 and UCP5--proteins related to a decrease in ROS production--were also higher in females.	ros	74-77	solute carrier family 25, member 27	Rattus norvegicus	25-29
19074984-6	2009	AngII increased mitochondrial ROS and decreased mitochondrial membrane potential, and these effects of AngII were significantly suppressed by blockade of either AT1R or AT2R.	ros	30-33	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-5
19074984-6	2009	AngII increased mitochondrial ROS and decreased mitochondrial membrane potential, and these effects of AngII were significantly suppressed by blockade of either AT1R or AT2R.	ros	30-33	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	103-108
19190950-3	2009	DHA (50 muM) produced a ROS induction in cells and aggravated the LysoPtdCho-induced oxidative stress.	ros	24-27	latexin	Homo sapiens	8-11
19267992-0	2009	VDUP1 potentiates Ras-mediated angiogenesis via ROS production in endothelial cells.	ros	48-51	thioredoxin interacting protein	Homo sapiens	0-5
19267992-5	2009	Enforced expression of VDUP1 increases ROS production and proliferation of Ras-overexpressing endothelial cells.	ros	39-42	thioredoxin interacting protein	Homo sapiens	23-28
19267992-7	2009	In addition, the removal of ROS by ROS scavenger attenuates the effect of VDUP1 on tube formation.	ros	28-31	thioredoxin interacting protein	Homo sapiens	74-79
19267992-7	2009	In addition, the removal of ROS by ROS scavenger attenuates the effect of VDUP1 on tube formation.	ros	35-38	thioredoxin interacting protein	Homo sapiens	74-79
19267992-8	2009	These results suggest that VDUP1 is involved in Ras-mediated angiogenesis via ROS generation in endothelial cells.	ros	78-81	thioredoxin interacting protein	Homo sapiens	27-32
18952326-7	2009	LCT/MCT increased ROS production to 146% of unstimulated cells.	ros	18-21	solute carrier family 16 member 1	Homo sapiens	4-7
19010591-0	2009	Polygonatum cyrtonema lectin induces apoptosis and autophagy in human melanoma A375 cells through a mitochondria-mediated ROS-p38-p53 pathway.	ros	122-125	mitogen-activated protein kinase 14	Homo sapiens	126-129
19010591-5	2009	Moreover, we confirmed that the ROS-p38-p53 pathway was involved in PCL-induced autophagy.	ros	32-35	mitogen-activated protein kinase 14	Homo sapiens	36-39
19010591-5	2009	Moreover, we confirmed that the ROS-p38-p53 pathway was involved in PCL-induced autophagy.	ros	32-35	tumor protein p53	Homo sapiens	40-43
19010591-6	2009	In conclusion, these results indicate that PCL induces apoptosis and autophagy via a mitochondrial-mediated ROS-p38-p53 pathway.	ros	108-111	mitogen-activated protein kinase 14	Homo sapiens	112-115
19071156-6	2009	IFN-gamma treatment increased ROS production, and an antioxidant, N-acetylcysteine, inhibited IFN-gamma-induced cellular senescence.	ros	30-33	interferon gamma	Homo sapiens	0-9
19161983-2	2009	Here, we report that Ang II-induced MC apoptosis in a time-dependent manner and up-regulated TLR4/MyD88 expression, and that the intracellular ROS was subsequently increased.	ros	143-146	angiotensinogen	Homo sapiens	21-27
19041937-8	2009	Total LV ROS production was significantly higher in TNF animals than in controls; APO or Temp treatment ameliorated TNF-induced LV ROS production.	ros	9-12	tumor necrosis factor	Rattus norvegicus	52-55
19041937-8	2009	Total LV ROS production was significantly higher in TNF animals than in controls; APO or Temp treatment ameliorated TNF-induced LV ROS production.	ros	131-134	tumor necrosis factor	Rattus norvegicus	116-119
19041937-9	2009	Total mitochondrial ROS production was significantly higher in the TNF and TNF+ APO groups than in the control and TNF+ Temp groups.	ros	20-23	tumor necrosis factor	Rattus norvegicus	67-70
19041937-9	2009	Total mitochondrial ROS production was significantly higher in the TNF and TNF+ APO groups than in the control and TNF+ Temp groups.	ros	20-23	tumor necrosis factor	Rattus norvegicus	75-78
19041937-9	2009	Total mitochondrial ROS production was significantly higher in the TNF and TNF+ APO groups than in the control and TNF+ Temp groups.	ros	20-23	tumor necrosis factor	Rattus norvegicus	75-78
19267281-3	2009	Paradoxically, during acute lung injury, overproduction of NO via inducible NO synthase (iNOS) and oxidative stress lead to reactive oxygen and nitrogen species (ROS and RNS) formation and vascular dysfunction.	ros	162-165	nitric oxide synthase 2	Homo sapiens	66-87
19267281-3	2009	Paradoxically, during acute lung injury, overproduction of NO via inducible NO synthase (iNOS) and oxidative stress lead to reactive oxygen and nitrogen species (ROS and RNS) formation and vascular dysfunction.	ros	162-165	nitric oxide synthase 2	Homo sapiens	89-93
19383369-5	2009	Treatment with Ebselen also down-regulated the enhanced ROS production of TNFalpha treated glioma cells.	ros	56-59	tumor necrosis factor	Homo sapiens	74-82
20157595-8	2009	Finally, we document that the Sch9p kinase is a key downstream effector of OXPHOS, ROS and CLS in the TOR-mitochondria pathway.	ros	83-86	serine/threonine protein kinase SCH9	Saccharomyces cerevisiae S288C	30-35
19113979-3	2009	ROS production induced by complex 1 treatment activated apoptosis through mitochondrial membrane depolarization in all prostate cancer cells, with up-regulation of Bax and down-regulation of Bcl-2 proteins.	ros	0-3	BCL2 associated X, apoptosis regulator	Homo sapiens	164-167
19113979-3	2009	ROS production induced by complex 1 treatment activated apoptosis through mitochondrial membrane depolarization in all prostate cancer cells, with up-regulation of Bax and down-regulation of Bcl-2 proteins.	ros	0-3	BCL2 apoptosis regulator	Homo sapiens	191-196
19137062-4	2009	Under these conditions, PS1/PS2 double-knockout MEFs showed aberrant accumulation of phospho-beta-catenin, higher ROS generation, and notable cell death.	ros	114-117	taste 2 receptor member 64 pseudogene	Homo sapiens	28-31
18495130-3	2009	Angiotensin II in addition to stimulating vasoconstriction also induces an increase in ROS and a proinflammatory phenotype via AT(1)R.	ros	87-90	angiotensinogen	Homo sapiens	0-14
20150959-4	2009	In the present study, the concentrations of IL-8 in culture supernatants of HeLa cells treated with ROS were determined by enzyme-linked immunosorbent assay.	ros	100-103	C-X-C motif chemokine ligand 8	Homo sapiens	44-48
20150959-7	2009	Enzyme-linked immunosorbent assays showed that IL-8 protein secretion was elevated in ROS-treated HeLa cells.	ros	86-89	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
20150959-9	2009	Collectively, these results indicate that Fe(2+)-mediated Erk pathway activation is an important signal transduction pathway in ROS-induced IL-8 secretion in epithelial cells.	ros	128-131	mitogen-activated protein kinase 1	Homo sapiens	58-61
20150959-9	2009	Collectively, these results indicate that Fe(2+)-mediated Erk pathway activation is an important signal transduction pathway in ROS-induced IL-8 secretion in epithelial cells.	ros	128-131	C-X-C motif chemokine ligand 8	Homo sapiens	140-144
19009558-0	2009	Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation.	ros	112-115	mitogen-activated protein kinase 14	Homo sapiens	135-138
19009558-0	2009	Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation.	ros	112-115	mitogen-activated protein kinase 1	Homo sapiens	139-143
19009558-4	2009	N-Acetylcysteine (ROS scavenger) and BAPTA-AM (Ca(2+) chelator) abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored phosphorylation of ERK.	ros	18-21	mitogen-activated protein kinase 14	Homo sapiens	74-77
19009558-4	2009	N-Acetylcysteine (ROS scavenger) and BAPTA-AM (Ca(2+) chelator) abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored phosphorylation of ERK.	ros	18-21	mitogen-activated protein kinase 1	Homo sapiens	78-82
19009558-8	2009	Taken together, our results indicate that PLA(2)-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca(2+)- and ROS-evoked p38 MAPK activation, and suggest that non-catalytic PLA(2) plays a role for the signaling pathway.	ros	157-160	mitogen-activated protein kinase 14	Homo sapiens	168-171
19009558-8	2009	Taken together, our results indicate that PLA(2)-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca(2+)- and ROS-evoked p38 MAPK activation, and suggest that non-catalytic PLA(2) plays a role for the signaling pathway.	ros	157-160	mitogen-activated protein kinase 1	Homo sapiens	172-176
18991268-5	2008	In contrast, most antioxidant enzymes were increased in SK-N-SH cells in response to capsaicin, where catalase might play a pivotal role in maintenance of low ROS levels in the course of apoptosis.	ros	159-162	catalase	Homo sapiens	102-110
19292057-7	2009	RESULTS: TGF-beta1 at 10 ng/mL significantly increased the intercellular ROS production and p47phox expression (P &lt; 0.05).	ros	73-76	transforming growth factor, beta 1	Rattus norvegicus	9-18
19292057-9	2009	Compared to TGF-beta1-induced group, G-Rb1 and DPI depressed TGF-beta1-induced ROS production and p47phox overexpression.	ros	79-82	transforming growth factor, beta 1	Rattus norvegicus	61-70
19292057-11	2009	CONCLUSION: G-Rb1 could inhibit TGF-beta1 induced ROS production and decrease the levels of Col-I and FN in a dose-dependent manner.	ros	50-53	transforming growth factor, beta 1	Rattus norvegicus	32-41
18802921-6	2008	Introduction of hrVEGF(165) initiated ROS-mediated intracellular signaling, resulting in kinase activation and phosphorylation of KDR and Erk1/2.	ros	38-41	mitogen-activated protein kinase 3	Homo sapiens	138-144
18818525-9	2008	DHC attenuated basal ROS levels through catalase induction; this effect was enhanced by antioxidants, which increased both LC3-II expression and caspase-3 activation.	ros	21-24	catalase	Homo sapiens	40-48
18771958-5	2008	Incubating IL-20 with mesangial cells upregulated the transcripts of CCL2 (MCP-1), CCL5 (RANTES), CXCL10 (IP-10), IL-6, iNOS, and ROS, all of which are involved in the pathogenesis of lupus nephritis.	ros	130-133	interleukin 20	Homo sapiens	11-16
18718526-2	2008	Despite extensive genomic identity with NOD (&gt;70%), ALR mice display strong resistance to autoimmune type 1 diabetes (T1D) due to both an unusual elevation in systemic antioxidant defenses and a reduction in cellular ROS production that extends to the beta cell level.	ros	220-223	growth factor, augmenter of liver regeneration	Mus musculus	55-58
18983820-2	2008	Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-Jun N-terminal Kinase1 (JNK1) is indispensable for TGF-beta1-induced apoptosis pathway, but the relationship between radical oxygen species (ROS) and the activation of JNKs is still unclear.	ros	217-220	mitogen-activated protein kinase 8	Homo sapiens	74-98
18983820-2	2008	Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-Jun N-terminal Kinase1 (JNK1) is indispensable for TGF-beta1-induced apoptosis pathway, but the relationship between radical oxygen species (ROS) and the activation of JNKs is still unclear.	ros	217-220	mitogen-activated protein kinase 8	Homo sapiens	100-104
18983820-2	2008	Reports have demonstrated that TGF-beta1 can induce oxidative stress, and c-Jun N-terminal Kinase1 (JNK1) is indispensable for TGF-beta1-induced apoptosis pathway, but the relationship between radical oxygen species (ROS) and the activation of JNKs is still unclear.	ros	217-220	transforming growth factor beta 1	Homo sapiens	127-136
18983820-3	2008	In the present study, we found that ROS can induce JNK activation in TGF-beta1 mediated apoptosis in hepatocytes.	ros	36-39	mitogen-activated protein kinase 8	Homo sapiens	51-54
18983820-3	2008	In the present study, we found that ROS can induce JNK activation in TGF-beta1 mediated apoptosis in hepatocytes.	ros	36-39	transforming growth factor beta 1	Homo sapiens	69-78
17560688-3	2008	Neuroglobin (Ngb), a newly discovered globin in vertebrates that exhibits neuroprotective functions, may have a potential role in scavenging ROS.	ros	141-144	neuroglobin	Rattus norvegicus	0-11
17560688-3	2008	Neuroglobin (Ngb), a newly discovered globin in vertebrates that exhibits neuroprotective functions, may have a potential role in scavenging ROS.	ros	141-144	neuroglobin	Rattus norvegicus	13-16
17560688-6	2008	Overexpression of Ngb but not Ngb mutant in the PC12 cells significantly attenuated Abeta-induced ROS production and lipids peroxidation.	ros	98-101	neuroglobin	Rattus norvegicus	18-21
17560688-8	2008	Therefore, Ngb may act as an intracellular ROS scavenger, and such antioxidant properties may play a protective role against Abeta-induced cell injury.	ros	43-46	neuroglobin	Rattus norvegicus	11-14
18771651-7	2008	Both BAX(oligo)- and alamethicin-induced cytochrome c releases were accompanied by inhibition of ROS generation, which was assessed by measuring mitochondrial H(2)O(2) release with an Amplex Red assay.	ros	97-100	BCL2 associated X, apoptosis regulator	Homo sapiens	5-8
18771651-8	2008	The mPT inhibitors antagonized suppression of ROS generation caused by BAX(oligo) but not by alamethicin.	ros	46-49	BCL2 associated X, apoptosis regulator	Homo sapiens	71-81
18775488-11	2008	Taken together, these results demonstrate that the gAd-induced apoptotic process in RAW264 cells involves ROS and RNS, which are generated by NADPH oxidases and iNOS, respectively.	ros	106-109	nitric oxide synthase 2, inducible	Mus musculus	161-165
18767115-9	2008	Further experiments suggested that XOR derived ROS mediated this effect and also modulated COX-2 and MMP levels and function.	ros	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	91-96
18830414-7	2008	Accordingly, both CK2 inhibitors and ROS scavengers restored PTEN activity and impaired PI3K/Akt signaling in T-ALL cells.	ros	37-40	AKT serine/threonine kinase 1	Homo sapiens	93-96
18991268-8	2008	It was concluded that the different relationship between endogenous ROS levels and apoptosis of two cancer cells presumably resulted from complicated expression patterns of many oxidative stress and antioxidant genes, rather than the individual role of some classical antioxidant enzymes such as SOD and catalase.	ros	68-71	catalase	Homo sapiens	304-312
18829485-8	2008	The induction of many of these genes with SOD2 knockdown, such as VEGFA and FKBP5, is reversible with the antioxidant N-acetylcysteine, suggesting that this mechanism is directly linked to ROS.	ros	189-192	vascular endothelial growth factor A	Homo sapiens	66-71
18757489-7	2008	Interestingly, in cells expressing heme-free sGC, H(2)O(2) inhibited instead of potentiated HMR-1766 responses, suggesting that the ROS-induced enhancement of cGMP formation was heme dependent.	ros	132-135	sarcoglycan beta	Homo sapiens	45-48
18829485-8	2008	The induction of many of these genes with SOD2 knockdown, such as VEGFA and FKBP5, is reversible with the antioxidant N-acetylcysteine, suggesting that this mechanism is directly linked to ROS.	ros	189-192	FKBP prolyl isomerase 5	Homo sapiens	76-81
18723357-5	2008	Furthermore, preliminary biochemical investigation revealed that CLT was a potent agent to suppress both LPS-induced intracellular ROS production and iNOS expression, and CLT also inhibited the phosphorylation of ERK which is an important protein kinase involved in the activation of TNF-alpha synthesis in LPS-activated macrophages.	ros	131-134	mitogen-activated protein kinase 1	Homo sapiens	213-216
18543263-6	2008	This condition has been shown to promote insulin resistance by interfering with phosphorylation of proteins of the insulin pathway including insulin receptor substrate-1/2 (IRS), phosphatidylinositol-3-kinase, (PI3-kinase) and protein kinase C. Although the molecular mechanism is not completely understood, elevated reactive oxygen (ROS) and nitrogen species (RNS) are involved in this process.	ros	334-337	insulin	Homo sapiens	41-48
18543263-6	2008	This condition has been shown to promote insulin resistance by interfering with phosphorylation of proteins of the insulin pathway including insulin receptor substrate-1/2 (IRS), phosphatidylinositol-3-kinase, (PI3-kinase) and protein kinase C. Although the molecular mechanism is not completely understood, elevated reactive oxygen (ROS) and nitrogen species (RNS) are involved in this process.	ros	334-337	insulin	Homo sapiens	115-122
18543263-6	2008	This condition has been shown to promote insulin resistance by interfering with phosphorylation of proteins of the insulin pathway including insulin receptor substrate-1/2 (IRS), phosphatidylinositol-3-kinase, (PI3-kinase) and protein kinase C. Although the molecular mechanism is not completely understood, elevated reactive oxygen (ROS) and nitrogen species (RNS) are involved in this process.	ros	334-337	insulin	Homo sapiens	115-122
18543263-7	2008	Elevated ROS/RNS activates nuclear factor-kappaB (NFkB), which promotes the transcription of proinflammatory tumoral necrosis factor alpha (TNFalpha), decreasing the insulin response.	ros	9-12	tumor necrosis factor	Homo sapiens	140-148
18543263-7	2008	Elevated ROS/RNS activates nuclear factor-kappaB (NFkB), which promotes the transcription of proinflammatory tumoral necrosis factor alpha (TNFalpha), decreasing the insulin response.	ros	9-12	insulin	Homo sapiens	166-173
18625331-1	2008	Hypoxia maintained biological characteristics of CD34(+) cells through keeping lower intracellular reactive oxygen specials (ROS) levels.	ros	125-128	CD34 molecule	Homo sapiens	49-53
18602074-4	2008	It showed significant suppressive effect on ROS generation in response to TNF-alpha stimulation and it blocked nuclear factor-kappa B (NF-kappaB) p65 translocation into the nucleus and phosphorylation of inhibitory factor kappaBalpha (IkappaBalpha).	ros	44-47	tumor necrosis factor	Homo sapiens	74-83
18634846-7	2008	Furthermore, EPO also attenuated the downstream cascade following ROS, including Bcl-2/Bax, and caspase-3 activation.	ros	66-69	BCL2, apoptosis regulator	Rattus norvegicus	81-86
18657320-3	2008	In HeLa cells, Hep3B cells, and A549 cells, DNA-binding activity of NF-kappaB was induced by NAC without any other stimulation but not by tetramethylthiourea (TMTU) or vitamin C, suggesting that ROS is not involved in the effect of NAC.	ros	195-198	nuclear factor kappa B subunit 1	Homo sapiens	68-77
18695917-9	2008	These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations.	ros	267-270	mitogen-activated protein kinase 14	Homo sapiens	42-45
18695917-9	2008	These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations.	ros	267-270	BCL2 associated X, apoptosis regulator	Homo sapiens	97-100
18695917-9	2008	These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations.	ros	267-270	mitogen-activated protein kinase 8	Homo sapiens	131-134
18695917-9	2008	These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations.	ros	267-270	mitogen-activated protein kinase 14	Homo sapiens	139-142
18695917-9	2008	These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations.	ros	267-270	BCL2 apoptosis regulator	Homo sapiens	183-188
18695917-9	2008	These results indicate that activation of p38 MAPK is specifically required for translocation of Bax to the mitochondria, and both JNK and p38 MAPK are involved in phosphorylation of Bcl-2 in response to combination treatment with gamma-radiation and As2O3, and that ROS is a critical regulator of p38 MAPK and JNK activations.	ros	267-270	mitogen-activated protein kinase 14	Homo sapiens	139-142
18385754-7	2008	We further showed that the ROS-induced degradation of BCR-ABL was mediated partially by caspase-3 and the proteasome pathway.	ros	27-30	caspase 3	Homo sapiens	88-97
18459142-9	2008	This lower HIF-1alpha stabilization is parallel to a decreased inducible NO synthase induction and NO production, a higher response of some antioxidant enzymes (particularly glutathione peroxidase and glutathione reductase) and a lower ROS level.	ros	236-239	hypoxia inducible factor 1 subunit alpha	Homo sapiens	11-21
18593583-5	2008	These results suggest that regulation of the anti-oxidant enzyme HO-1 via the PI3K and p38/Nrf2 signaling pathways controls the intracellular levels of ROS.	ros	152-155	mitogen-activated protein kinase 14	Homo sapiens	87-90
18593583-5	2008	These results suggest that regulation of the anti-oxidant enzyme HO-1 via the PI3K and p38/Nrf2 signaling pathways controls the intracellular levels of ROS.	ros	152-155	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
18467643-4	2008	Nox4 overexpression substantially increased basal ROS generation whereas ROS generation in response to angiotensin II and tumor necrosis factor (TNF)alpha was enhanced in Nox2-overexpressing cells.	ros	73-76	angiotensinogen	Homo sapiens	103-143
18467643-4	2008	Nox4 overexpression substantially increased basal ROS generation whereas ROS generation in response to angiotensin II and tumor necrosis factor (TNF)alpha was enhanced in Nox2-overexpressing cells.	ros	73-76	tumor necrosis factor	Homo sapiens	145-154
18433991-2	2008	We also described that the NFkappaB pathway exerts a downstream control on the expression of the ROS-dependent cellular migratory potential.	ros	97-100	nuclear factor kappa B subunit 1	Homo sapiens	27-35
18459142-4	2008	The activity of HIF-1 is determined by the accumulation of its alpha subunit which is regulated, in part, by oxidative stress (ROS) and nitric oxide (NO), both of them highly dependent on PARP-1.	ros	127-130	hypoxia inducible factor 1 subunit alpha	Homo sapiens	16-21
18459142-4	2008	The activity of HIF-1 is determined by the accumulation of its alpha subunit which is regulated, in part, by oxidative stress (ROS) and nitric oxide (NO), both of them highly dependent on PARP-1.	ros	127-130	poly(ADP-ribose) polymerase 1	Homo sapiens	188-194
18682040-4	2008	When ROS containing bleached rhodopsin (R(*)) were centrifuged in low ionic strength buffer, G(t-) remained associated with the membrane fraction, whereas G(t-)GDP remained in the soluble fraction.	ros	5-8	rhodopsin	Homo sapiens	29-38
18423410-6	2008	Excessive ROS caused oxidative damage to the mitochondrial membranes and impaired the membrane integrity, leading to cytochrome c release, caspase activation, and apoptosis.	ros	10-13	cytochrome c, somatic	Homo sapiens	117-129
18202321-5	2008	In addition, inhibiting ROS production stimulated by TS/IL-1beta decreased activation of Src, EGFR and p38MAPK, phosphorylation of PTEN, VE-cadherin and beta-catenin, and abrogated the effect of TS/IL-1beta to disorganize adherens junctions, resulting in reduced endothelial permeability and decreased nuclear beta-catenin accumulation.	ros	24-27	phosphatase and tensin homolog	Mus musculus	131-135
18563732-7	2008	We identified TNBS-induced ROS and myeloperoxidase (MPO) proteins and demonstrated that the increase in ROS resulted in IL-12 production.	ros	104-107	myeloperoxidase	Homo sapiens	52-55
18064629-10	2008	We conclude that atRA protects against UV-induced down-regulation AQP3 and decrease in water permeability, reduction in cell migration and delayed in vitro wound healing via trans-activation of EGFR and inhibition on ROS-mediated MEK/ERK pathway.	ros	217-220	mitogen-activated protein kinase kinase 7	Homo sapiens	230-233
18064629-10	2008	We conclude that atRA protects against UV-induced down-regulation AQP3 and decrease in water permeability, reduction in cell migration and delayed in vitro wound healing via trans-activation of EGFR and inhibition on ROS-mediated MEK/ERK pathway.	ros	217-220	mitogen-activated protein kinase 1	Homo sapiens	234-237
18239155-1	2008	OBJECTIVE: PARP-1, a DNA base repair enzyme, is activated by DNA breaks induced by oxidative (ROS) and nitrosative (RNS) stress.	ros	94-97	poly(ADP-ribose) polymerase 1	Homo sapiens	11-17
18239155-6	2008	Here we investigated the hypothesis that PARP-1 inhibition protects human umbilical vein endothelial cells (HUVECs) from ROS- and RNS-induced cell death by limiting NAD(+) depletion and by activating a prosurvival signaling pathway via VEGFR2 phosphorylation.	ros	121-124	poly(ADP-ribose) polymerase 1	Homo sapiens	41-47
18239155-13	2008	CONCLUSIONS: PARP-1 inhibition prevents ROS- and RNS-induced HUVEC death by maintaining cellular energy in the form of NAD(+) and ATP, and also by activating a survival pathway via VEGFR2, Akt, and BAD phosphorylation.	ros	40-43	poly(ADP-ribose) polymerase 1	Homo sapiens	13-19
18348865-7	2008	The expression of BID, a known transcriptional target protein of PLZF, was decreased, and the consequent apoptosis was induced by the ROS generated during serum starvation.	ros	134-137	BH3 interacting domain death agonist	Homo sapiens	18-21
18202147-8	2008	Based on these analyses, we propose that, in ROS cells, the presence of NHERF1 induces PTH-dependent calcium signaling by a cAMP-mediated mechanism that involves local protein kinase A-dependent activation of calcium channels.	ros	45-48	parathyroid hormone	Rattus norvegicus	87-90
18343732-7	2008	High expression of phosphorylated p16(INK4a), which is caused by oxidative stress and accumulative ROS, can prevent tumor cells from unlimited division and becoming malignant ones by accelerating premalignant cells premature senescence.	ros	99-102	cyclin dependent kinase inhibitor 2A	Homo sapiens	34-37
18343732-7	2008	High expression of phosphorylated p16(INK4a), which is caused by oxidative stress and accumulative ROS, can prevent tumor cells from unlimited division and becoming malignant ones by accelerating premalignant cells premature senescence.	ros	99-102	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-43
18343732-8	2008	It has been demonstrated that the expression of p16(INK4a) increases remarkably with age due to oxidative stress and accumulative ROS in some stem and progenitor cells, and regulates these cells age-dependent senescence.	ros	130-133	cyclin dependent kinase inhibitor 2A	Homo sapiens	48-51
18343732-8	2008	It has been demonstrated that the expression of p16(INK4a) increases remarkably with age due to oxidative stress and accumulative ROS in some stem and progenitor cells, and regulates these cells age-dependent senescence.	ros	130-133	cyclin dependent kinase inhibitor 2A	Homo sapiens	52-57
18239155-13	2008	CONCLUSIONS: PARP-1 inhibition prevents ROS- and RNS-induced HUVEC death by maintaining cellular energy in the form of NAD(+) and ATP, and also by activating a survival pathway via VEGFR2, Akt, and BAD phosphorylation.	ros	40-43	AKT serine/threonine kinase 1	Homo sapiens	189-192
18202321-5	2008	In addition, inhibiting ROS production stimulated by TS/IL-1beta decreased activation of Src, EGFR and p38MAPK, phosphorylation of PTEN, VE-cadherin and beta-catenin, and abrogated the effect of TS/IL-1beta to disorganize adherens junctions, resulting in reduced endothelial permeability and decreased nuclear beta-catenin accumulation.	ros	24-27	cadherin 5	Mus musculus	137-148
18202321-7	2008	CONCLUSIONS: TS interaction with IL-1beta modulates PTEN activity though the ROS/Src/EGFR-p38MAPK pathway.	ros	77-80	phosphatase and tensin homolog	Mus musculus	52-56
18243471-3	2008	The increased ROS by cerium oxide nanoparticles triggered the activation of cytosolic caspase-3 and chromatin condensation, which means that cerium oxide nanoparticles exert cytotoxicity by an apoptotic process.	ros	14-17	caspase 3	Homo sapiens	86-95
18219322-6	2008	TNF-induced SENP1 nuclear translocation is specifically blocked by antioxidants such as N-acetyl-cysteine, suggesting that TNF-induced translocation of SENP1 is ROS dependent.	ros	161-164	tumor necrosis factor	Mus musculus	0-3
18219322-6	2008	TNF-induced SENP1 nuclear translocation is specifically blocked by antioxidants such as N-acetyl-cysteine, suggesting that TNF-induced translocation of SENP1 is ROS dependent.	ros	161-164	tumor necrosis factor	Mus musculus	123-126
18262205-0	2008	YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1.	ros	113-116	angiotensinogen	Rattus norvegicus	87-101
18262205-4	2008	Treatment with YS 49 significantly and dose-dependently inhibited Ang II-induced VSMC proliferation, ROS production, and phosphorylation of JNK, but not P38 MAP kinase or ERK1/2.	ros	101-104	angiotensinogen	Rattus norvegicus	66-72
18249093-4	2008	While ET-1 may induce Sp1 expression via both PKC-and MAPK-dependent pathways, activation of NF-kappaB by ET-1 is mediated by a PKCepsilon/reactive oxygen species (ROS) cascade.	ros	164-167	endothelin 1	Homo sapiens	106-110
18249093-5	2008	Taken together, these results suggest that by activating NF-kappaB via PKCepsilon/ROS cascade and increasing Sp1 expression through both PKCepsilon- and MAPK-dependent pathways, ET-1 may activate Glut1 transcription by enhancing interaction between nuclear NF-kappaB and Sp1 as well as their binding to enhancer 2.	ros	82-85	endothelin 1	Homo sapiens	178-182
18211830-3	2008	Primary sources of ROS and RNS in smooth muscle are several isoforms of NADPH oxidase (Nox) and the cytokine-regulated inducible nitric oxide (NO) synthase (iNOS).	ros	19-22	nitric oxide synthase 2	Homo sapiens	157-161
18211830-5	2008	In this review, we discuss the literature that supports an alternate possibility: Nox-derived ROS modulate NO bioavailability by altering the expression of iNOS.	ros	94-97	nitric oxide synthase 2	Homo sapiens	156-160
18211830-8	2008	A central hypothesis discussed is that ROS-dependent regulation of the serine/threonine kinase protein kinase Cdelta is essential to understanding how Nox may regulate signaling pathways leading to iNOS expression.	ros	39-42	nitric oxide synthase 2	Homo sapiens	198-202
18234233-2	2008	Furthermore, we identified the contribution of ROS production system (e.g., oxidant enzymes, such as iNOS and Cox-2) to the apoptosis induction in the chorion cells, suggesting an important role of the two inducible enzymes in the induction process.	ros	47-50	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	110-115
18221936-3	2008	Cytotoxicity was preceded by ROS formation which was markedly increased by inactivating DT-diaphorase or catalase but were prevented by a subtoxic concentration of the mitochondrial respiratory inhibitor cyanide.	ros	29-32	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	88-101
18221936-3	2008	Cytotoxicity was preceded by ROS formation which was markedly increased by inactivating DT-diaphorase or catalase but were prevented by a subtoxic concentration of the mitochondrial respiratory inhibitor cyanide.	ros	29-32	catalase	Rattus norvegicus	105-113
18221936-4	2008	This suggests that ROS generation could be attributed to a futile two-electron redox cycle involving oxidation of phenylenediamine to the corresponding diimine by the mitochondrial electron transfer chain and re-reduction by the DT-diaphorase.	ros	19-22	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	229-242
19704716-0	2008	The ascorbate peroxidase regulated by H(2)O(2) and ethylene is involved in cotton fiber cell elongation by modulating ROS homeostasis.	ros	118-121	peroxidase 42-like	Gossypium hirsutum	14-24
18064039-4	2008	In addition, the data reveal that gzmB(+)CTL independently induce pro-apoptotic processes either via caspase-3/-7, leading to plasma membrane perturbance and ROS production or via Bid/Bak/Bax, resulting in cytochrome c release and that both pathways elicit loss of DeltaPsi(m).	ros	158-161	caspase 3	Homo sapiens	101-113
19704716-1	2008	Ascorbate peroxidase (APX) is a reactive oxygen species (ROSs) scavenging enzyme involved in regulation of intracellular ROS levels by reduction of H(2)O(2) to water using ascorbate as an electron donor.	ros	57-60	peroxidase 42-like	Gossypium hirsutum	10-20
18219386-2	2008	In this issue of the JCI, Harraz and colleagues demonstrate that SOD1 mutants expressed in human cell lines directly stimulate NADPH oxidase (Nox) by binding to Rac1, resulting in overproduction of damaging ROS (see the related article beginning on page 659).	ros	207-210	superoxide dismutase 1	Homo sapiens	65-69
18083891-0	2008	Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.	ros	70-73	hypoxia inducible factor 1 subunit alpha	Homo sapiens	74-84
18083891-0	2008	Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.	ros	70-73	potassium voltage-gated channel subfamily A member 5	Homo sapiens	85-90
18083891-7	2008	O(2) sensing is mediated by this mitochondria-ROS-HIF-1alpha-Kv1.5 pathway.	ros	46-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	50-60
18083891-7	2008	O(2) sensing is mediated by this mitochondria-ROS-HIF-1alpha-Kv1.5 pathway.	ros	46-49	potassium voltage-gated channel subfamily A member 5	Homo sapiens	61-66
18083891-11	2008	Mitochondrial abnormalities that disturb the ROS-HIF-1alpha-Kv1.5 O(2)-sensing pathway contribute to the pathogenesis of PAH and cancer and constitute promising therapeutic targets.	ros	45-48	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
18083891-11	2008	Mitochondrial abnormalities that disturb the ROS-HIF-1alpha-Kv1.5 O(2)-sensing pathway contribute to the pathogenesis of PAH and cancer and constitute promising therapeutic targets.	ros	45-48	potassium voltage-gated channel subfamily A member 5	Homo sapiens	60-65
17999630-4	2008	Extracellular SOD (EC-SOD) is found predominantly in the extracellular matrix of tissues and is ideally situated to prevent cell and tissue damage initiated by extracellularly produced ROS.	ros	185-188	superoxide dismutase 3	Homo sapiens	0-17
17999630-4	2008	Extracellular SOD (EC-SOD) is found predominantly in the extracellular matrix of tissues and is ideally situated to prevent cell and tissue damage initiated by extracellularly produced ROS.	ros	185-188	superoxide dismutase 3	Homo sapiens	19-25
18082636-3	2008	Using flow-cytometry, we showed that in vitro treatment of blood cells from beta-thalassemic patients with AD4 elevated the reduced glutathione (GSH) content of red blood cells (RBC), platelets and polymorphonuclear (PMN) leukocytes, and reduced their ROS.	ros	252-255	presenilin 2	Homo sapiens	107-110
18005671-7	2008	The SOPC chlorohydrin-induced adhesion and ROS generation could be abrogated by pretreatment of the ApoE(-/-) mice with pravastatin or a nitrated derivative, NCX 6550.	ros	43-46	apolipoprotein E	Mus musculus	100-104
18309287-0	2008	Interleukin-2 promotes angiogenesis by activation of Akt and increase of ROS.	ros	73-76	interleukin 2	Homo sapiens	0-13
18309287-3	2008	IL-2 increased the ROS level and phosphorylation of Akt in human umbilical vein endothelial cells (HUVECs).	ros	19-22	interleukin 2	Homo sapiens	0-4
18309287-5	2008	The effect of IL-2 on angiogenesis and tube formation was mediated by ROS and Akt.	ros	70-73	interleukin 2	Homo sapiens	14-18
17980396-9	2008	Pretreatment with cell-permeable catalase, N-acetyl-L-cysteine or GSH-monoethyl ester markedly reduced expression of NQO-1 and GCLC under HOCl challenge conditions, suggesting intracellular ROS-scavenging capacity affects HOCl-induced Nrf2 activation.	ros	190-193	NAD(P)H quinone dehydrogenase 1	Homo sapiens	117-122
17924117-2	2008	Thus, these results suggest that activation of p38-like MAP kinase modulates guard cell ROS signaling in response to stress.	ros	88-91	mitogen-activated protein kinase 14	Homo sapiens	47-50
18053648-4	2008	Moraleja, B. Chakravarthy, Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca(2+) channels in NMDA-induced DPYSL3 degradation, Brain Res.	ros	68-71	dihydropyrimidinase-like 3	Rattus norvegicus	148-154
17334903-5	2008	The results suggest that the E7 oncogene would induce higher resistance to ROS-induced cell injury in the E7-infected cells via the upregulation of catalase.	ros	75-78	catalase	Homo sapiens	148-156
18045550-2	2008	Because redox regulation by thioredoxin (Trx) plays a crucial role in signal transduction and cytoprotection against ROS, the effects of resveratrol on the changes in the amounts of thioredoxin were monitored in an attempt to determine the role of intracellular thioredoxin in resveratrol-mediated changes in intracellular redox environment and its role in resveratrol-mediated cardioprotection.	ros	117-120	thioredoxin 1	Rattus norvegicus	41-44
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	ros	185-188	tumor necrosis factor	Homo sapiens	60-69
19017476-7	2008	From in vitro experiments, the cultured ROS cells expressed significantly higher ALPase activity and calcium deposition after P15 immobilization.	ros	40-43	cyclin dependent kinase inhibitor 2B	Homo sapiens	126-129
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	ros	185-188	interleukin 6	Homo sapiens	87-91
19017476-8	2008	The results demonstrated that the ROS cells expressed osteoblastic phenotypes more significantly when cultured with the substrate modified with P15.	ros	34-37	cyclin dependent kinase inhibitor 2B	Homo sapiens	144-147
18289111-0	2008	Redox state of cytochrome c regulates cellular ROS and caspase cascade in permeablized cell model.	ros	47-50	cytochrome c, somatic	Homo sapiens	15-27
18670615-7	2008	Importantly, in several cancer cells, proline oxidase may be an important mediator of the PPARgamma-stimulated generation of ROS and induction of apoptosis.	ros	125-128	peroxisome proliferator activated receptor gamma	Homo sapiens	90-99
18535297-8	2008	ABA-responsive TFs were more induced in NOJ compared with SUL, including WRKY1, mediating a response in SA signalling that may give rise to increased ROS.	ros	150-153	probable WRKY transcription factor 75-like	Solanum tuberosum	73-78
18395354-3	2008	Many biological molecules, such as ROS, IRS-1, PI3K, have been identified involving in the causes of insulin resistance.	ros	35-38	insulin	Homo sapiens	101-108
18160848-4	2007	Treatment of astrocytes with cell-permeable SOD led to decrease in Tat-induced ROS generation as well as NF-kappaB activation.	ros	79-82	superoxide dismutase 1	Homo sapiens	44-47
18160848-8	2007	These data indicate that SOD has a regulatory function for HIV-1 Tat-induced NF-kappaB activation in astrocytes and suggest that cell-permeable SOD can be used as a feasible therapeutic agent for regulation of ROS-related neurological diseases.	ros	210-213	superoxide dismutase 1	Homo sapiens	25-28
18160848-8	2007	These data indicate that SOD has a regulatory function for HIV-1 Tat-induced NF-kappaB activation in astrocytes and suggest that cell-permeable SOD can be used as a feasible therapeutic agent for regulation of ROS-related neurological diseases.	ros	210-213	superoxide dismutase 1	Homo sapiens	144-147
18001034-6	2007	Berberine also inhibited the generation of ROS and the subsequent mitochondrial membrane potential collapse, chromosome condensation, cytochrome C release, and caspase-3 activation induced by oxLDL in HUVECs.	ros	43-46	cytochrome c, somatic	Homo sapiens	134-146
18001034-6	2007	Berberine also inhibited the generation of ROS and the subsequent mitochondrial membrane potential collapse, chromosome condensation, cytochrome C release, and caspase-3 activation induced by oxLDL in HUVECs.	ros	43-46	caspase 3	Homo sapiens	160-169
17913704-3	2007	In cardiac myocytes isolated from control rats, TNFalpha induced ROS production, exerted a dual positive and negative action on [Ca(2+)] transient and cell fractional shortening, and altered cell survival.	ros	65-68	tumor necrosis factor	Rattus norvegicus	48-56
18036344-6	2007	Furthermore, we demonstrate that Compound C functions as a repressor of HIF-1 by inhibiting respiration and suppressing mitochondrial generated ROS.	ros	144-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	72-77
17913704-4	2007	Neutralizing anti-TNFR2 antibodies exacerbated TNFalpha responses on ROS production and cell death, arguing for a major protective role of the TNFR2 pathway.	ros	69-72	tumor necrosis factor	Rattus norvegicus	47-55
17826739-5	2007	We investigated how AtNDPK2 overexpression influences the response of rice plants to marker genes related to chilling and ROS stress.	ros	122-125	nucleoside diphosphate kinase 2	Arabidopsis thaliana	20-27
17906102-1	2007	It is known that TNF-alpha increases the production of ROS and decreases antioxidant enzymes, resulting in an increase in oxidative stress.	ros	55-58	tumor necrosis factor	Rattus norvegicus	17-26
17906102-6	2007	Exposure to TNF-alpha significantly increased ROS production, caused cell injury, and increased the number of apoptotic cells and Bax-to-Bcl-xl ratio.	ros	46-49	tumor necrosis factor	Rattus norvegicus	12-21
17683071-3	2007	NF-kappaB and the MAPK pathway are activated by ROS, which results in the activation of stress-inducible genes, including ho-1.	ros	48-51	nuclear factor kappa B subunit 1	Homo sapiens	0-9
17960249-6	2007	TNF-alpha induced ROS-dependent genetic instability in Fancc-/- but not in WT cells.	ros	18-21	tumor necrosis factor	Mus musculus	0-9
17960249-6	2007	TNF-alpha induced ROS-dependent genetic instability in Fancc-/- but not in WT cells.	ros	18-21	Fanconi anemia, complementation group C	Mus musculus	55-60
18084847-2	2007	We have previously shown that nifedipine, one of the most popular DHPs, blocks tumour necrosis factor-alpha (TNF-alpha)-induced monocyte chemoattractant protein-1 as well as vascular cell adhesion molecule-1 (VCAM-1) expression in endothelial cells by suppressing reactive oxygen species generation (ROS).	ros	300-303	tumor necrosis factor	Homo sapiens	109-118
18084847-5	2007	In HUVECs, 10 ng/ml TNF-alpha for 4 h stimulated ROS generation and subsequently upregulated VCAM-1 mRNA levels, both of which were dose-dependently blocked by Bay w 9798.	ros	49-52	tumor necrosis factor	Homo sapiens	20-29
18084847-6	2007	The results demonstrated that Bay w 9798 inhibited VCAM-1 expression in TNF-alpha-exposed cells by suppressing ROS generation.	ros	111-114	vascular cell adhesion molecule 1	Homo sapiens	51-57
18084847-6	2007	The results demonstrated that Bay w 9798 inhibited VCAM-1 expression in TNF-alpha-exposed cells by suppressing ROS generation.	ros	111-114	tumor necrosis factor	Homo sapiens	72-81
17707342-1	2007	It has been reported that genipin, the aglycone of geniposide, induces apoptotic cell death in human hepatoma cells via a NADPH oxidase-reactive oxygen species (ROS)-c-Jun NH(2)-terminal kinase (JNK)-dependent activation of mitochondrial pathway.	ros	161-164	mitogen-activated protein kinase 8	Homo sapiens	195-198
18036328-14	2007	CONCLUSION: Aldosterone upregulates the production of PAI-1 by MCs and increases the expression of TGF-beta1 and cellular ROS in the MCs significantly, which is mediated through mineralocorticoid receptor.	ros	122-125	nuclear receptor subfamily 3, group C, member 2	Rattus norvegicus	178-204
17707342-8	2007	Taken together, our observations suggest genipin signaling to apoptosis of PC3 cells is mediated via activation of ROS-dependent MLK3, which leads to downstream activation of JNK.	ros	115-118	mitogen-activated protein kinase 8	Homo sapiens	175-178
17894456-3	2007	Results revealed that glyoxal (GO) and methylglyoxal (MGO) resulting from the glycative and autoxidative reactions of the high blood sugar glucose (G) evoked a huge production of ROS and NO, which in turn increased the production of peroxynitrite, combined with the activation of the nuclear factor kappaB (NFkappaB), leading to cell apoptosis.	ros	179-182	nuclear factor kappa B subunit 1	Homo sapiens	284-305
17894456-3	2007	Results revealed that glyoxal (GO) and methylglyoxal (MGO) resulting from the glycative and autoxidative reactions of the high blood sugar glucose (G) evoked a huge production of ROS and NO, which in turn increased the production of peroxynitrite, combined with the activation of the nuclear factor kappaB (NFkappaB), leading to cell apoptosis.	ros	179-182	nuclear factor kappa B subunit 1	Homo sapiens	307-315
17615382-10	2007	Inhibition of ROS by catalase (200 microg/mL) prevented ERK1/2 phosphorylation and CRP mRNA transcription.	ros	14-17	mitogen-activated protein kinase 3	Homo sapiens	56-62
17615382-10	2007	Inhibition of ROS by catalase (200 microg/mL) prevented ERK1/2 phosphorylation and CRP mRNA transcription.	ros	14-17	C-reactive protein	Homo sapiens	83-86
17615382-11	2007	CONCLUSION: Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2.	ros	101-104	C-reactive protein	Homo sapiens	27-30
17853336-14	2007	In conclusion, increased ROS levels in hypothyroidism may result in a pro-oxidation environment, which in turn could result in decreased antioxidant PON1 activity, increased MDA and NO levels.	ros	25-28	paraoxonase 1	Homo sapiens	149-153
17379464-4	2007	The apparent contradiction between increased ROS generation and long lifespan in daf-2(e1370) is reconciled by an enhanced stress defense, acknowledging oxidative damage as a probable cause of aging.	ros	45-48	Insulin-like receptor subunit beta;Protein kinase domain-containing protein;Receptor protein-tyrosine kinase	Caenorhabditis elegans	81-86
17458902-0	2007	IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells.	ros	54-57	insulin like growth factor 1	Homo sapiens	0-5
17458902-9	2007	These results indicate that IGF-I interacts with E2 to promote the proliferation of breast carcinoma cells via ROS-dependent MAPK activation and c-Jun protein expression.	ros	111-114	insulin like growth factor 1	Homo sapiens	28-33
17846503-6	2007	It also caused a loss of mitochondrial membrane potential that induced release of cytochrome c and apoptosis inducing factor (AIF) into the cytoplasm, enhancing ROS generation and subsequently resulting in apoptosis.	ros	161-164	cytochrome c, somatic	Homo sapiens	82-94
17914162-6	2007	IL-1beta-induced beta cell destruction may be mediated by the generation of NO and/or ROS, although the relative importance of NO and ROS in this process remains unclear.	ros	86-89	interleukin 1 beta	Rattus norvegicus	0-8
17914162-6	2007	IL-1beta-induced beta cell destruction may be mediated by the generation of NO and/or ROS, although the relative importance of NO and ROS in this process remains unclear.	ros	134-137	interleukin 1 beta	Rattus norvegicus	0-8
17705636-5	2007	Moreover, both gamma-H2AX focus formation and micronucleus formation in bystander cells were inhibited by the ROS scavengers SOD or catalase or the NO scavenger PTIO.	ros	110-113	catalase	Homo sapiens	132-140
17562703-7	2007	Furthermore, transfection of HPAECs with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated ROS production and the hyperoxia-induced translocation of p47(phox) to the cell periphery.	ros	150-153	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	100-103
17603020-6	2007	Indeed, overexpression of UCP2 in the GC-2 germ cell line protected the cells from radical oxygen species (ROS)-induced apoptosis.	ros	107-110	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	26-30
17603020-7	2007	Taken together, we propose that UCP2 may represent an effective weaponry used by germ cells to combat ROS-induced apoptosis.	ros	102-105	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	32-36
17573344-7	2007	The inhibition of PKC further augments Akt activity, which in turn induces ROS production and the accumulation of unfolded proteins in the endoplasmic reticulum, resulting in cell death.	ros	75-78	AKT serine/threonine kinase 1	Homo sapiens	39-42
17532579-12	2007	We conclude that neuroglobin or cytoglobin act as ROS scavengers under ischemic conditions.	ros	50-53	cytoglobin	Homo sapiens	32-42
17631927-6	2007	In addition, ROS scavenger pretreatment suppressed 15d-PGJ(2)-induced HO-1 expression while PPARgamma antagonist did not, suggesting nuclear translocation of Nrf-2 and subsequent HO-1 expression was ROS dependent rather than PPARgamma dependent.	ros	13-16	NFE2 like bZIP transcription factor 2	Rattus norvegicus	158-163
17631927-6	2007	In addition, ROS scavenger pretreatment suppressed 15d-PGJ(2)-induced HO-1 expression while PPARgamma antagonist did not, suggesting nuclear translocation of Nrf-2 and subsequent HO-1 expression was ROS dependent rather than PPARgamma dependent.	ros	199-202	NFE2 like bZIP transcription factor 2	Rattus norvegicus	158-163
17631927-9	2007	The present study reports for the first time that 15d-PGJ(2) induces HO-1 expression possibly using Nrf-2 pathway as a response to ROS in VSMCs.	ros	131-134	NFE2 like bZIP transcription factor 2	Rattus norvegicus	100-105
17392377-2	2007	In particular, individual ROS appear to have differing effects on NF-kappaB activation dependent on the cell population studied.	ros	26-29	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
17560946-4	2007	We found inducible nitric oxide synthase (iNOS) was involved in the generation of ROS induced by ER stress.	ros	82-85	nitric oxide synthase 2, inducible	Mus musculus	9-40
17560946-4	2007	We found inducible nitric oxide synthase (iNOS) was involved in the generation of ROS induced by ER stress.	ros	82-85	nitric oxide synthase 2, inducible	Mus musculus	42-46
17671650-4	2007	In view of this striking finding, we investigated the potential role of Foxo3 in the regulation of ROS in erythropoiesis.	ros	99-102	forkhead box O3	Homo sapiens	72-77
17671650-6	2007	Foxo3-deficient erythrocytes exhibited decreased expression of ROS scavenging enzymes and had a ROS-mediated shortened lifespan and evidence of oxidative damage.	ros	63-66	forkhead box O3	Homo sapiens	0-5
17671650-6	2007	Foxo3-deficient erythrocytes exhibited decreased expression of ROS scavenging enzymes and had a ROS-mediated shortened lifespan and evidence of oxidative damage.	ros	96-99	forkhead box O3	Homo sapiens	0-5
17671650-8	2007	We identified ROS-mediated upregulation of p21(CIP1/WAF1/Sdi1) (also known as Cdkn1a) as a major contributor to the interference with cell cycle progression in Foxo3-deficient erythroid precursor cells.	ros	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	43-46
17671650-8	2007	We identified ROS-mediated upregulation of p21(CIP1/WAF1/Sdi1) (also known as Cdkn1a) as a major contributor to the interference with cell cycle progression in Foxo3-deficient erythroid precursor cells.	ros	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-51
17671650-8	2007	We identified ROS-mediated upregulation of p21(CIP1/WAF1/Sdi1) (also known as Cdkn1a) as a major contributor to the interference with cell cycle progression in Foxo3-deficient erythroid precursor cells.	ros	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	52-56
17671650-8	2007	We identified ROS-mediated upregulation of p21(CIP1/WAF1/Sdi1) (also known as Cdkn1a) as a major contributor to the interference with cell cycle progression in Foxo3-deficient erythroid precursor cells.	ros	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	57-61
17671650-8	2007	We identified ROS-mediated upregulation of p21(CIP1/WAF1/Sdi1) (also known as Cdkn1a) as a major contributor to the interference with cell cycle progression in Foxo3-deficient erythroid precursor cells.	ros	14-17	cyclin dependent kinase inhibitor 1A	Homo sapiens	78-84
17671650-8	2007	We identified ROS-mediated upregulation of p21(CIP1/WAF1/Sdi1) (also known as Cdkn1a) as a major contributor to the interference with cell cycle progression in Foxo3-deficient erythroid precursor cells.	ros	14-17	forkhead box O3	Homo sapiens	160-165
17392377-1	2007	Although ROS can participate in modulating the activity of the transcriptional factor NF-kappaB and expression of NF-kappaB-dependent genes, the mechanisms involved and the roles of specific ROS have not been fully determined.	ros	9-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-95
17392377-1	2007	Although ROS can participate in modulating the activity of the transcriptional factor NF-kappaB and expression of NF-kappaB-dependent genes, the mechanisms involved and the roles of specific ROS have not been fully determined.	ros	9-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	114-123
17392377-1	2007	Although ROS can participate in modulating the activity of the transcriptional factor NF-kappaB and expression of NF-kappaB-dependent genes, the mechanisms involved and the roles of specific ROS have not been fully determined.	ros	191-194	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	86-95
17567683-6	2007	Under mild or severe H2O2-induced stress, p53-deficient SiHa cells exhibited much higher ROS levels than control SiHa cells.	ros	89-92	tumor protein p53	Homo sapiens	42-45
17532486-10	2007	The notion of induction of HO-1 gene expression through a ROS-dependent manner suppressing H(2)O(2)-induced cell death is identified in the present study.	ros	58-61	heme oxygenase 1	Mus musculus	27-31
17567683-4	2007	Downregulation of p53 resulted in the inhibition of p53-regulated antioxidant enzymes and elevated intracellular ROS in SiHa cells.	ros	113-116	tumor protein p53	Homo sapiens	18-21
17457038-8	2007	Thus, mtDNA deletions could induce ATG12 through a mechanism such as the following: deletions &gt; mitochondrial protein synthesis inhibition or ROS &gt; proteasome inhibition &gt; amino acid depletion &gt; ATG12.	ros	145-148	autophagy related 12	Homo sapiens	35-40
17532486-0	2007	Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression.	ros	64-67	heme oxygenase 1	Mus musculus	78-94
17243115-4	2007	The present study investigates the regulation of BSP transcription in a rat osteoblast-like cell line, ROS 17/2.8 cells, by quercetin and its conjugated metabolite quercetin 3-glucuronide.	ros	103-106	integrin-binding sialoprotein	Rattus norvegicus	49-52
17512464-3	2007	The generation of ROS by FMLP-activated neutrophils was monitored according to the magnitude of oxygen consumption and autoiodination, while spectrofluorimetric procedures were used to measure alterations in membrane potential and influx of Ca(2+).	ros	18-21	formyl peptide receptor 1	Homo sapiens	25-29
17258890-5	2007	Otherwise, TNFalpha and FasL stimulation led to radical oxygen species (ROS) generation and ASK1 (Apoptosis-signal-regulating-kinase-1) activation.	ros	72-75	tumor necrosis factor	Homo sapiens	11-19
17258890-7	2007	Altogether, our results suggest that TNFalpha- and FasL-stimulated AML cell lytic induction is regulated by a signalling pathway involving sequentially, ROS generation, Trx oxidation, ASK1 activation, p38MAPK stimulation and GrB induction at mRNA and protein levels.	ros	153-156	tumor necrosis factor	Homo sapiens	37-45
17462535-10	2007	This study establishes that AGE activate iNOS in VSMC through a ROS-sensitive, NF-kappaB-dependent mechanism involving ROS generation by a Nox1-based oxidase.	ros	64-67	nitric oxide synthase 2	Homo sapiens	41-45
17583356-7	2007	In addition, resistance PAs are unique in having mitochondria which dynamically alter production of reactive O(2) species (ROS) in proportion to PO(2), thereby regulating K(+) channel activity and controlling expression through transcription factors, such as HIF-1alpha.	ros	123-126	hypoxia inducible factor 1 subunit alpha	Homo sapiens	259-269
17879738-1	2007	OBJECTIVE: To investigate the effects of Rehmannia glutinosa oligosaccharides (ROS) on the proliferation of HepG2 and insulin resistance.	ros	79-82	insulin	Homo sapiens	118-125
17879738-4	2007	Insulin resistant HepG2 cells model was induced by high concentration of insulin, then the effects of ROS on glucose consumption in insulin resistant HepG2 cells were investigated.	ros	102-105	insulin	Homo sapiens	0-7
17879738-4	2007	Insulin resistant HepG2 cells model was induced by high concentration of insulin, then the effects of ROS on glucose consumption in insulin resistant HepG2 cells were investigated.	ros	102-105	insulin	Homo sapiens	132-139
17879738-7	2007	ROS promoted the glucose consumption in insulin resistance of HepG2 cells, improved the sensitivity of insulin resistance of HepG2 cells to insulin.	ros	0-3	insulin	Homo sapiens	40-47
17879738-7	2007	ROS promoted the glucose consumption in insulin resistance of HepG2 cells, improved the sensitivity of insulin resistance of HepG2 cells to insulin.	ros	0-3	insulin	Homo sapiens	103-110
17879738-7	2007	ROS promoted the glucose consumption in insulin resistance of HepG2 cells, improved the sensitivity of insulin resistance of HepG2 cells to insulin.	ros	0-3	insulin	Homo sapiens	103-110
17879738-9	2007	ROS can significantly improve insulin resistance of HepG2 cells induced by high insulin.	ros	0-3	insulin	Homo sapiens	30-37
17879738-9	2007	ROS can significantly improve insulin resistance of HepG2 cells induced by high insulin.	ros	0-3	insulin	Homo sapiens	80-87
17462535-10	2007	This study establishes that AGE activate iNOS in VSMC through a ROS-sensitive, NF-kappaB-dependent mechanism involving ROS generation by a Nox1-based oxidase.	ros	119-122	nitric oxide synthase 2	Homo sapiens	41-45
17611319-10	2007	CONCLUSION: ADMA can induce the HSC activation by increasing TGF-beta(1) expression through ROS-NF-kappaB-dependent pathway.	ros	92-95	transforming growth factor, beta 1	Rattus norvegicus	61-72
17352382-6	2007	Also hypoosmotic exposure of wilde type mouse cortical brain slices increased ROS generation, which was allocated in part to the astrocytes and which was absent in presence of apocynin and in cortical brain slices from p47(phox) knock-out mice.	ros	78-81	NSFL1 (p97) cofactor (p47)	Mus musculus	219-222
17352382-8	2007	The data suggest that astrocyte swelling triggers a p47(phox)-dependent NADPH oxidase-catalyzed ROS production.	ros	96-99	NSFL1 (p97) cofactor (p47)	Mus musculus	52-55
17352382-1	2007	The role of NADPH oxidase (NOX) and the regulatory subunit p47(phox) for hypoosmotic ROS generation was studied in cultured rat astrocytes and brain slices of wilde type and p47(phox) knock-out mice.	ros	85-88	NSFL1 cofactor	Rattus norvegicus	59-62
21179752-10	2007	CONCLUSION: EGb and Que could inhibit AngII-induced cardiomyocyte hypertrophy through a ROS-dependent pathway, the effect of Que might be related to the JNK and c-fos cascade.	ros	88-91	angiotensinogen	Rattus norvegicus	38-43
17352382-3	2007	Hypoosmotic (205 mosmol/L) swelling of cultured astrocytes induced a rapid generation of ROS that was accompanied by serine phosphorylation of p47(phox) and prevented by the NADPH oxidase inhibitor apocynin.	ros	89-92	NSFL1 (p97) cofactor (p47)	Mus musculus	143-146
17404266-7	2007	Furthermore, UA induced intracellular ROS generation for IL-1beta production, which was suppressed by an antioxidant.	ros	38-41	interleukin 1 beta	Mus musculus	57-65
17349976-0	2007	ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.	ros	0-3	CCAAT enhancer binding protein alpha	Homo sapiens	70-80
17349976-0	2007	ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.	ros	0-3	signal transducer and activator of transcription 3	Homo sapiens	85-91
17349976-8	2007	These results suggest that ROS repress the hepcidin gene by preventing C/EBPalpha and STAT-3 binding to hepcidin promoter during hypoxia.	ros	27-30	CCAAT enhancer binding protein alpha	Homo sapiens	71-81
17349976-8	2007	These results suggest that ROS repress the hepcidin gene by preventing C/EBPalpha and STAT-3 binding to hepcidin promoter during hypoxia.	ros	27-30	signal transducer and activator of transcription 3	Homo sapiens	86-92
17306223-7	2007	After CuOOH exposure MGST1 significantly lowered intracellular ROS as determined by FACS analysis.	ros	63-66	microsomal glutathione S-transferase 1	Homo sapiens	21-26
17030476-11	2007	This latter mechanism may be due to the preservation of endogenous GPx1 from ROS/RNS induced degradation and/or the stimulation of GPx1 expression or activity.	ros	77-80	glutathione peroxidase 1	Rattus norvegicus	67-71
17318262-8	2007	First, Akt may stabilize cells with extensive mitochondrial DNA mutation, which can generate ROS.	ros	93-96	AKT serine/threonine kinase 1	Homo sapiens	7-10
17341580-9	2007	Reformation of the mitochondrial tubules by expressing the dominant interfering DRP1 or by RNA silencing of endogenous DRP1 protein rescued both the morphological aberrations and the increased production of ROS induced by downregulation of SENP5.	ros	207-210	SUMO specific peptidase 5	Homo sapiens	240-245
17318262-9	2007	Second, Akt can induce expression of the ROS-generating enzyme NOX4.	ros	41-44	AKT serine/threonine kinase 1	Homo sapiens	8-11
17208437-6	2007	In addition, we found that elevation of cytoplasmic calcium concentration is involved in 1,25D anti-apoptotic effects via Akt activation in ROS 17/2.8 cells and non-osteoblastic CV-1 cells.	ros	140-143	AKT serine/threonine kinase 1	Rattus norvegicus	122-125
17046344-6	2007	The PTH-dependent activation of Akt was also detected in other osteoblastic cell lines, SaOS-2 and ROS 17/2.8.	ros	99-102	AKT serine/threonine kinase 1	Rattus norvegicus	32-35
17011624-0	2007	Cross-linking of MHC class II molecules interferes with phorbol 12,13-dibutyrate-induced differentiation of resting B cells by inhibiting Rac-associated ROS-dependent ERK/p38 MAP kinase pathways leading to NF-kappaB activation.	ros	153-156	mitogen-activated protein kinase 14	Homo sapiens	171-174
17011624-5	2007	We also found that this inhibition was mediated through down-regulation of the activated Rac/ROS-associated ERK/p38 MAPK signaling pathway in PDBU-treated 38B9 cells.	ros	93-96	mitogen-activated protein kinase 14	Homo sapiens	112-115
17005604-10	2007	p38 and JNK stimulation by CML-collagen was almost entirely blocked when formation of ROS was inhibited and was partially reduced by NO and ceramide inhibitors.	ros	86-89	mitogen-activated protein kinase 14	Homo sapiens	0-3
17005604-10	2007	p38 and JNK stimulation by CML-collagen was almost entirely blocked when formation of ROS was inhibited and was partially reduced by NO and ceramide inhibitors.	ros	86-89	mitogen-activated protein kinase 8	Homo sapiens	8-11
17276741-2	2007	A model of respiratory chain operating with two electron-leak pathways mediated by cytochrome c is suggested to illustrate the controlling mechanism of ROS level in mitochondria.	ros	152-155	cytochrome c, somatic	Homo sapiens	83-95
16762411-8	2006	These results suggest that in M07e cells calmodulin and CAMKII are involved in GLUT1 stimulation by cytokines and ROS.	ros	114-117	calmodulin 1	Homo sapiens	41-51
17543193-7	2006	The endothelial cell NADPH oxidase and endothelial cell MMP activities are required for VCAM-1-dependent lymphocyte migration as determined by scavenging of ROS, by pharmacologic or antisense inhibition of NADPH oxidase and by pharmacologic inhibition of endothelial cell MMPs.	ros	157-160	vascular cell adhesion molecule 1	Homo sapiens	88-94
17010408-3	2006	One of the candidates for an ARF4 effector is the ARF-GAP ASAP1, which may function as a subunit of, or form a novel protein coat involved in trafficking from the TGN and in cytoskeletal remodeling, whose assembly is regulated by the binding of ARF4 to rhodopsin, and whose function is essential for the polarized trafficking toward the ROS.	ros	337-340	ADP ribosylation factor 4	Homo sapiens	29-33
17010408-3	2006	One of the candidates for an ARF4 effector is the ARF-GAP ASAP1, which may function as a subunit of, or form a novel protein coat involved in trafficking from the TGN and in cytoskeletal remodeling, whose assembly is regulated by the binding of ARF4 to rhodopsin, and whose function is essential for the polarized trafficking toward the ROS.	ros	337-340	ADP ribosylation factor 4	Homo sapiens	245-249
17010408-3	2006	One of the candidates for an ARF4 effector is the ARF-GAP ASAP1, which may function as a subunit of, or form a novel protein coat involved in trafficking from the TGN and in cytoskeletal remodeling, whose assembly is regulated by the binding of ARF4 to rhodopsin, and whose function is essential for the polarized trafficking toward the ROS.	ros	337-340	rhodopsin	Homo sapiens	253-262
17184774-0	2007	Diphenyleneiodonium induces ROS-independent p53 expression and apoptosis in human RPE cells.	ros	28-31	tumor protein p53	Homo sapiens	44-47
17184774-5	2007	ROS have been implicated as a key factor in the activation of p53 by many chemotherapeutic drugs.	ros	0-3	tumor protein p53	Homo sapiens	62-65
17184774-10	2007	We conclude that DPI induces the expression of p53 by ROS-independent mechanism in ARPE-19 cells, and renders cells sensitive to drug-induced apoptosis by induction of p53 expression.	ros	54-57	tumor protein p53	Homo sapiens	47-50
17352223-0	2007	ROS mediates baicalin-induced apoptosis in human promyelocytic leukemia HL-60 cells through the expression of the Gadd153 and mitochondrial-dependent pathway.	ros	0-3	DNA damage inducible transcript 3	Homo sapiens	114-121
17097057-4	2006	In response to LPS stimuli, nrf2-deficient (nrf2 -/-) peritoneal neutrophils showed increased NADPH oxidase-dependent ROS generation, proinflammatory cytokines (Tnf-alpha and Il-6) and chemokines (Mip2 and Mcp-1) relative to wild-type (nrf2 +/+) cells.	ros	118-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
17097057-4	2006	In response to LPS stimuli, nrf2-deficient (nrf2 -/-) peritoneal neutrophils showed increased NADPH oxidase-dependent ROS generation, proinflammatory cytokines (Tnf-alpha and Il-6) and chemokines (Mip2 and Mcp-1) relative to wild-type (nrf2 +/+) cells.	ros	118-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48
17097057-4	2006	In response to LPS stimuli, nrf2-deficient (nrf2 -/-) peritoneal neutrophils showed increased NADPH oxidase-dependent ROS generation, proinflammatory cytokines (Tnf-alpha and Il-6) and chemokines (Mip2 and Mcp-1) relative to wild-type (nrf2 +/+) cells.	ros	118-121	nuclear factor, erythroid derived 2, like 2	Mus musculus	44-48
17097057-5	2006	Pretreatment of peritoneal neutrophils with CDDO-Im induced antioxidative genes (Ho-1, Gclc, Gclm, and Nqo1) and attenuated LPS induced ROS generation as well as expression of proinflammatory cytokines exclusively in nrf2 +/+ neutrophils but not in nrf2 -/- cells.	ros	136-139	toll-like receptor 4	Mus musculus	124-127
17215069-4	2006	This is because ROS and RNS can exert a vast variety of toxic actions, e.g., through lipid peroxidation, DNA strand breakage followed by PARP activation and subsequent cellular energy depletion, production of inflammatory cytokines, and activation of matrix metalloproteinases.	ros	16-19	poly(ADP-ribose) polymerase 1	Homo sapiens	137-141
17262974-0	2006	[Mechanisms of ROS induced by angiotensin II and its roles in vascular damage].	ros	15-18	angiotensinogen	Homo sapiens	30-44
16904205-2	2006	Growth inhibition of cancer cells is dependent on ROS and ERK1/2 induction as indicated by a significantly reduced PDTC-associated growth inhibition by the free radical scavenger N-acetyl-L-cysteine (NAC) or the MEK/ERK1/2 inhibitor (PD98059).	ros	50-53	mitogen-activated protein kinase kinase 7	Homo sapiens	212-215
16899228-6	2006	PMA-induced mitochondrial localization of PKCalpha was accompanied by increased mitochondrial PKC activity, altered cell morphology, disruption of mitochondrial membrane potential, decreased complex I and pyruvate dehydrogenase activities, and increased mitochondrial ROS production.	ros	268-271	protein kinase C, alpha	Mus musculus	42-50
16899228-6	2006	PMA-induced mitochondrial localization of PKCalpha was accompanied by increased mitochondrial PKC activity, altered cell morphology, disruption of mitochondrial membrane potential, decreased complex I and pyruvate dehydrogenase activities, and increased mitochondrial ROS production.	ros	268-271	protein kinase C, alpha	Mus musculus	42-45
16904205-2	2006	Growth inhibition of cancer cells is dependent on ROS and ERK1/2 induction as indicated by a significantly reduced PDTC-associated growth inhibition by the free radical scavenger N-acetyl-L-cysteine (NAC) or the MEK/ERK1/2 inhibitor (PD98059).	ros	50-53	mitogen-activated protein kinase 3	Homo sapiens	216-222
16904205-0	2006	Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate.	ros	59-62	cyclin dependent kinase inhibitor 1A	Homo sapiens	23-36
16904205-0	2006	Increased stability of P21(WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate.	ros	59-62	mitogen-activated protein kinase 1	Homo sapiens	63-66
16904205-3	2006	Moreover, ERK1/2 induction is dependent on ROS production as demonstrated by a complete removal of PDTC-mediated ERK1/2 phosphorylation by NAC.	ros	43-46	mitogen-activated protein kinase 3	Homo sapiens	10-16
16904205-3	2006	Moreover, ERK1/2 induction is dependent on ROS production as demonstrated by a complete removal of PDTC-mediated ERK1/2 phosphorylation by NAC.	ros	43-46	mitogen-activated protein kinase 3	Homo sapiens	113-119
16904205-4	2006	p21(WAF1/CIP1) activation has a central role in growth inhibition by PDTC, as revealed by P21(WAF1/CIP1) silencing experiments with antisense oligonucleotide, and occurs via increased mRNA stability largely mediated by ROS/ERK induction.	ros	219-222	cyclin dependent kinase inhibitor 1A	Homo sapiens	0-3
16904205-4	2006	p21(WAF1/CIP1) activation has a central role in growth inhibition by PDTC, as revealed by P21(WAF1/CIP1) silencing experiments with antisense oligonucleotide, and occurs via increased mRNA stability largely mediated by ROS/ERK induction.	ros	219-222	cyclin dependent kinase inhibitor 1A	Homo sapiens	4-8
16904205-4	2006	p21(WAF1/CIP1) activation has a central role in growth inhibition by PDTC, as revealed by P21(WAF1/CIP1) silencing experiments with antisense oligonucleotide, and occurs via increased mRNA stability largely mediated by ROS/ERK induction.	ros	219-222	cyclin dependent kinase inhibitor 1A	Homo sapiens	9-13
16955146-1	2006	ROS are a risk factor of several cardiovascular disorders and interfere with NO/soluble guanylyl cyclase/cyclic GMP (NO/sGC/cGMP) signaling through scavenging of NO and formation of the strong oxidant peroxynitrite.	ros	0-3	sarcoglycan beta	Homo sapiens	120-123
16885344-0	2006	ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.	ros	0-3	mechanistic target of rapamycin kinase	Homo sapiens	105-134
16772302-1	2006	Hyperosmotic exposure of rat hepatocytes induced a rapid oxidative-stress(ROS) response as an upstream signal for proapoptotic CD95 activation.	ros	74-77	Fas (TNF receptor superfamily member 6)	Mus musculus	127-131
16885344-5	2006	Here, we show that a glioblastoma-associated, ligand-independent rearrangement product of ROS (FIG-ROS) cooperates with loss of the tumor suppressor gene locus Ink4a;Arf to produce glioblastomas in the mouse.	ros	90-93	cyclin dependent kinase inhibitor 2A	Mus musculus	160-169
16885344-5	2006	Here, we show that a glioblastoma-associated, ligand-independent rearrangement product of ROS (FIG-ROS) cooperates with loss of the tumor suppressor gene locus Ink4a;Arf to produce glioblastomas in the mouse.	ros	99-102	cyclin dependent kinase inhibitor 2A	Mus musculus	160-169
16885344-6	2006	We show that this FIG-ROS-mediated tumor formation in vivo parallels the activation of the tyrosine phosphatase SH2 domain-containing phosphatase-2 (SHP-2) and a phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling axis in tumors and tumor-derived cell lines.	ros	22-25	AKT serine/threonine kinase 1	Homo sapiens	192-195
16885344-6	2006	We show that this FIG-ROS-mediated tumor formation in vivo parallels the activation of the tyrosine phosphatase SH2 domain-containing phosphatase-2 (SHP-2) and a phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling axis in tumors and tumor-derived cell lines.	ros	22-25	mechanistic target of rapamycin kinase	Homo sapiens	196-225
17119268-13	2006	A "dual PPARgamma-PPARalpha agonists" (e.g PIO, but ROS poorly activate PPARalpha) might lower glucose and modulate lipids.	ros	52-55	peroxisome proliferator activated receptor gamma	Homo sapiens	8-27
16889072-2	2006	Incubation of SGC-7901 cells with H. pylori simultaneously caused a significant increase of DNA damage (DNA strand breakage and DNA fragmentation) and ROS formation, as well as a significant decrease of intracellular GSH content in a H. pylori multiplicity of infection (MOI) dependent manner in gastric cells.	ros	151-154	sarcoglycan beta	Homo sapiens	14-17
16466682-3	2006	Treatment of ROS 17/2.8 cells with either 10 ng/ml FGF2 or 1 microM FSK for 6 h resulted in 5.4- and 8.2-fold increases, respectively, in the levels of BSP mRNA.	ros	13-16	integrin-binding sialoprotein	Rattus norvegicus	152-155
16819299-7	2006	Inhibition of ERK and p38 MAPK increased ROS levels in cells transfected with CAGE, suggesting that ROS reduce the motility of both cell lines.	ros	41-44	mitogen-activated protein kinase 14	Homo sapiens	22-25
16819299-7	2006	Inhibition of ERK and p38 MAPK increased ROS levels in cells transfected with CAGE, suggesting that ROS reduce the motility of both cell lines.	ros	100-103	mitogen-activated protein kinase 14	Homo sapiens	22-25
16815147-7	2006	RESULTS: In this study with an ovalbumin-induced murine model of allergic airway disease, the increased ROS generation and the increased expression of T(H)2 cell cytokines, adhesion molecules, chemokines, and vascular endothelial growth factor in lungs after ovalbumin inhalation were significantly reduced by the administration of PPARgamma agonists or AdPPARgamma.	ros	104-107	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	31-40
16778989-2	2006	Proinflammatory cytokines such as GM-CSF and TNF-alpha prime ROS production by neutrophils through unknown mechanisms.	ros	61-64	tumor necrosis factor	Homo sapiens	45-54
16778989-6	2006	Transfection of HL-60 cells with a mutated p47phox (S345A) inhibited GM-CSF- and TNF-alpha-induced priming of ROS production.	ros	110-113	tumor necrosis factor	Homo sapiens	81-90
16944596-9	2006	Another was that PNS caused an increase in the production of ROS in hippocampal CA3 region and ROS caused an increase in the phosphorylation of HVA Ca2+ channel of offspring hippocampal CA3 neurons.	ros	95-98	carbonic anhydrase 2	Rattus norvegicus	148-151
16527821-3	2006	Tumor necrosis factor (TNF) alpha challenge of wild type ECs caused p110gamma translocation to the plasma membrane and phosphatidylinositol 1,4,5-trisphosphate production coupled to ROS production; however, this response was blocked in p110gamma-/- ECs.	ros	182-185	tumor necrosis factor	Mus musculus	0-21
16527821-3	2006	Tumor necrosis factor (TNF) alpha challenge of wild type ECs caused p110gamma translocation to the plasma membrane and phosphatidylinositol 1,4,5-trisphosphate production coupled to ROS production; however, this response was blocked in p110gamma-/- ECs.	ros	182-185	tumor necrosis factor	Mus musculus	23-26
16527821-4	2006	ROS production was the result of TNFalpha activation of Ser phosphorylation of NADPH oxidase subunit p47(phox) and its translocation to EC membranes.	ros	0-3	tumor necrosis factor	Mus musculus	33-41
16428270-4	2006	The activities of RhoA, Rac1, and Cdc42 were correlated with changes in the endothelial cytoskeleton, adherens junctions, permeability, ROS production, VEGF levels, and activities of transcription factors hypoxia-inducible factor (HIF)-1alpha and NF-kappaB.	ros	136-139	ras homolog family member A	Homo sapiens	18-22
16632126-0	2006	Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway.	ros	100-103	tumor necrosis factor	Homo sapiens	28-37
16632126-0	2006	Notoginsenoside R1 inhibits TNF-alpha-induced fibronectin production in smooth muscle cells via the ROS/ERK pathway.	ros	100-103	fibronectin 1	Homo sapiens	46-57
16632126-8	2006	These results suggest that notoginsenoside R1 inhibits TNF-alpha-induced ERK activation and subsequent fibronectin overexpression and migration in HASMCs by suppressing NADPH oxidase-mediated ROS generation and directly scavenging ROS.	ros	192-195	tumor necrosis factor	Homo sapiens	55-64
16632126-5	2006	TNF-alpha significantly increased intracellular ROS generation and then ERK activation, which was blocked by notoginsenoside R1 or DPI and apocynin, inhibitors of NADPH oxidase, or the antioxidant NAC.	ros	48-51	tumor necrosis factor	Homo sapiens	0-9
16632126-8	2006	These results suggest that notoginsenoside R1 inhibits TNF-alpha-induced ERK activation and subsequent fibronectin overexpression and migration in HASMCs by suppressing NADPH oxidase-mediated ROS generation and directly scavenging ROS.	ros	231-234	tumor necrosis factor	Homo sapiens	55-64
16632126-6	2006	Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126.	ros	122-125	tumor necrosis factor	Homo sapiens	27-36
16632126-6	2006	Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126.	ros	122-125	fibronectin 1	Homo sapiens	61-72
16632126-6	2006	Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126.	ros	122-125	mitogen-activated protein kinase 1	Homo sapiens	126-129
16632126-6	2006	Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126.	ros	122-125	mitogen-activated protein kinase 1	Homo sapiens	212-216
16632126-6	2006	Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126.	ros	122-125	mitogen-activated protein kinase 1	Homo sapiens	217-220
16434028-7	2006	However, TNFalpha-stimulated intracellular ROS production was unaltered by kaempferol.	ros	43-46	tumor necrosis factor	Mus musculus	9-17
16331683-4	2006	Activation of a NADPH-oxidase-like system, which is responsible for the early ROS production by TGF-beta, is completely inhibited by EGF, through a PI 3-K-dependent mechanism.	ros	78-81	transforming growth factor, beta 1	Rattus norvegicus	96-104
16776966-8	2006	CONCLUSION: EGb and Que can inhibit AngII-induced cardiomyocyte hypertrophy through a ROS-dependent pathway.	ros	86-89	angiotensinogen	Rattus norvegicus	36-41
16497268-4	2006	E47 cells expressed high levels of CYP2E1 protein and catalytic activity which is associated with increased ROS generation, lipid peroxidation and the elevated presence of ubiquinated and aggregated proteins as compared to control HepG2 C34 cells which do not express CYP2E1.	ros	108-111	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	35-41
16537970-2	2006	TNF-alpha-induced liver injury: role of IKK, JNK, and ROS pathways.	ros	54-57	tumor necrosis factor	Homo sapiens	0-9
16537970-5	2006	This review summarizes recent advances in TNF-alpha signaling mechanisms that demonstrate how the IKK, ROS, and JNK pathways interact with each other to regulate hepatocyte apoptosis and proliferation.	ros	103-106	tumor necrosis factor	Homo sapiens	42-51
17089888-5	2006	Using murine embryonic cells lacking cytochrome c, we show that mitochondrial reactive O2 species (ROS) are essential for O2 sensing and subsequent HIF alpha stabilization at 1.5% O2.	ros	99-102	cytochrome c, somatic	Homo sapiens	37-49
16282349-3	2006	G-CSF stimulation showed a time- and dose-dependent increase in ROS production, correlating with activation of Lyn and Akt.	ros	64-67	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	111-114
16282349-3	2006	G-CSF stimulation showed a time- and dose-dependent increase in ROS production, correlating with activation of Lyn and Akt.	ros	64-67	AKT serine/threonine kinase 1	Homo sapiens	119-122
16282349-4	2006	Inhibition of Lyn, PI3-kinase, and Akt abrogated G-CSF-induced ROS production.	ros	63-66	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	14-17
16282349-4	2006	Inhibition of Lyn, PI3-kinase, and Akt abrogated G-CSF-induced ROS production.	ros	63-66	AKT serine/threonine kinase 1	Homo sapiens	35-38
16282349-12	2006	These data suggest that the G-CSF-induced Lyn-PI3K-Akt pathway drives ROS production.	ros	70-73	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	42-45
16282349-12	2006	These data suggest that the G-CSF-induced Lyn-PI3K-Akt pathway drives ROS production.	ros	70-73	AKT serine/threonine kinase 1	Homo sapiens	51-54
16282349-13	2006	One beneficial effect of therapeutic targeting of Lyn-PI3K-kinase-Akt cascade is abrogating ROS production.	ros	92-95	LYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
16282349-13	2006	One beneficial effect of therapeutic targeting of Lyn-PI3K-kinase-Akt cascade is abrogating ROS production.	ros	92-95	AKT serine/threonine kinase 1	Homo sapiens	66-69
16520238-4	2006	Increased catalase expression diminished constitutive ROS and enhanced viability after treatment with hydrogen peroxide.	ros	54-57	catalase	Mus musculus	10-18
16489404-3	2006	In present study, we discussed the effects of cell microfilament on the activity of collagen type I alpha 1 chain gene (COL1A1) promoter under microgravity simulated by clinostat and/or cytochalasin B as microfilament depolymerizer in the established EGFP-ROS cell line using the method of fluorescence semi-quantitative analysis and the fluorescent stain of microfilament.	ros	256-259	collagen type I alpha 1 chain	Rattus norvegicus	84-107
16489404-3	2006	In present study, we discussed the effects of cell microfilament on the activity of collagen type I alpha 1 chain gene (COL1A1) promoter under microgravity simulated by clinostat and/or cytochalasin B as microfilament depolymerizer in the established EGFP-ROS cell line using the method of fluorescence semi-quantitative analysis and the fluorescent stain of microfilament.	ros	256-259	collagen type I alpha 1 chain	Rattus norvegicus	120-126
16187297-4	2006	Treatment of osteoblast-like ROS 17/2.8 cells with LPS (1 microg/ml) for 12 h caused a marked reduction in BSP mRNA levels.	ros	29-32	integrin-binding sialoprotein	Rattus norvegicus	107-110
16582585-4	2006	To better understand the underlying mechanism, we introduced the PrP(C) and two pairs of RNAi into the poorly differentiated gastric cancer cell line AGS and found that PrP(C) suppressed ROS and slowed down apoptosis in transfected cells.	ros	187-190	prion protein	Homo sapiens	169-175
16146780-5	2006	In addition to direct effect of 17 beta-estradiol (E2) on mitochondria and redox cycling of catechol estrogens, E2-induced overexpression of IL-1 beta can produce an increase in the level of ROS.	ros	191-194	interleukin 1 beta	Homo sapiens	141-150
16298692-6	2005	We observed that the induction of TrxR2A resulted in increased apoptosis, due to the reduction of NADPH and alterations in cellular ROS levels.	ros	132-135	thioredoxin reductase 2	Homo sapiens	34-40
15908180-0	2005	Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway.	ros	122-125	mitogen-activated protein kinase 8	Homo sapiens	26-34
16195230-6	2005	In ROS 17/2.8 and MC3T3-E1 cells that contain endogenous Runx2, AML-1/ETO, which acts as a repressor of Runx2, significantly inhibited 1,25(OH)(2)D(3) induction of OPN transcription, OPN mRNA, and protein expression.	ros	3-6	RUNX1 translocation partner 1	Mus musculus	70-73
16327175-5	2005	The results indicated that during exposure of noisy environment ROS generation led to increase in corticosterone, LPO and SOD, but decrease in CAT, GPx, GSH, protein thiols, vitamins C and E levels.	ros	64-67	catalase	Rattus norvegicus	143-146
15908180-8	2005	Collectively, these data demonstrate that TNF-alpha/IFN-gamma synergistically activates JNK/SAPK, playing an important role in promoting apoptosis of pancreatic beta-cell via activation of p53 pathway together with ROS.	ros	215-218	interferon gamma	Homo sapiens	52-61
15908180-8	2005	Collectively, these data demonstrate that TNF-alpha/IFN-gamma synergistically activates JNK/SAPK, playing an important role in promoting apoptosis of pancreatic beta-cell via activation of p53 pathway together with ROS.	ros	215-218	mitogen-activated protein kinase 8	Homo sapiens	88-96
15908180-0	2005	Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway.	ros	122-125	tumor necrosis factor	Homo sapiens	46-55
15908180-0	2005	Synergistic activation of JNK/SAPK induced by TNF-alpha and IFN-gamma: apoptosis of pancreatic beta-cells via the p53 and ROS pathway.	ros	122-125	interferon gamma	Homo sapiens	60-69
15908180-2	2005	Using pancreatic beta-cell line MIN6N8 cells, co-treatment with TNF-alpha and IFN-gamma, but neither cytokine alone, synergistically induced apoptosis, correlated with the activation of the JNK/SAPK, which resulted in the production of reactive oxidative species (ROS) and loss of mitochondrial transmembrane potential (delta psi m).	ros	264-267	tumor necrosis factor	Mus musculus	64-73
15908180-2	2005	Using pancreatic beta-cell line MIN6N8 cells, co-treatment with TNF-alpha and IFN-gamma, but neither cytokine alone, synergistically induced apoptosis, correlated with the activation of the JNK/SAPK, which resulted in the production of reactive oxidative species (ROS) and loss of mitochondrial transmembrane potential (delta psi m).	ros	264-267	interferon gamma	Mus musculus	78-87
15908180-3	2005	Additionally, cells transfected with wild-type JNK1 became more susceptible to apoptosis induced by TNF-alpha/IFN-gamma through ROS production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative JNK1-transfected or JNK inhibitor SP600125-treated cells.	ros	128-131	mitogen-activated protein kinase 8	Homo sapiens	47-51
15908180-3	2005	Additionally, cells transfected with wild-type JNK1 became more susceptible to apoptosis induced by TNF-alpha/IFN-gamma through ROS production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative JNK1-transfected or JNK inhibitor SP600125-treated cells.	ros	128-131	tumor necrosis factor	Homo sapiens	100-109
15908180-3	2005	Additionally, cells transfected with wild-type JNK1 became more susceptible to apoptosis induced by TNF-alpha/IFN-gamma through ROS production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative JNK1-transfected or JNK inhibitor SP600125-treated cells.	ros	128-131	interferon gamma	Homo sapiens	110-119
15908180-3	2005	Additionally, cells transfected with wild-type JNK1 became more susceptible to apoptosis induced by TNF-alpha/IFN-gamma through ROS production and loss of delta psi m, while cascading apoptotic events were prevented in dominant-negative JNK1-transfected or JNK inhibitor SP600125-treated cells.	ros	128-131	mitogen-activated protein kinase 8	Homo sapiens	47-50
15908180-6	2005	Furthermore, the synergistic effect of TNF-alpha/IFN-gamma on apoptosis and ROS production was further potentiated by the overexpression of wild-type p53, but not with mutant p53.	ros	76-79	tumor necrosis factor	Homo sapiens	39-48
15908180-6	2005	Furthermore, the synergistic effect of TNF-alpha/IFN-gamma on apoptosis and ROS production was further potentiated by the overexpression of wild-type p53, but not with mutant p53.	ros	76-79	interferon gamma	Homo sapiens	49-58
15908180-6	2005	Furthermore, the synergistic effect of TNF-alpha/IFN-gamma on apoptosis and ROS production was further potentiated by the overexpression of wild-type p53, but not with mutant p53.	ros	76-79	tumor protein p53	Homo sapiens	150-153
15908180-7	2005	This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125.	ros	140-143	mitogen-activated protein kinase 8	Homo sapiens	31-34
15908180-7	2005	This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125.	ros	140-143	mitogen-activated protein kinase 9	Homo sapiens	35-39
15908180-7	2005	This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125.	ros	140-143	tumor necrosis factor	Homo sapiens	43-52
15908180-7	2005	This synergistic activation of JNK/SAPK by TNF-alpha/IFN-gamma was also induced in insulin-expressing pancreatic islet cells, and increased ROS production and p53 level, which was significantly inhibited by SP600125.	ros	140-143	interferon gamma	Homo sapiens	53-62
15908180-8	2005	Collectively, these data demonstrate that TNF-alpha/IFN-gamma synergistically activates JNK/SAPK, playing an important role in promoting apoptosis of pancreatic beta-cell via activation of p53 pathway together with ROS.	ros	215-218	tumor necrosis factor	Homo sapiens	42-51
16289095-8	2005	ROS formation by Cu(2+)/SO(3)(2-) was not inhibited by SOD but by catalase.	ros	0-3	catalase	Homo sapiens	66-74
16317705-4	2005	Bile acid-induced AKT activation was blunted by preventing ERBB1 activation and ROS generation.	ros	80-83	AKT serine/threonine kinase 1	Rattus norvegicus	18-21
16051297-0	2005	Rhodostomin inhibits thrombin-enhanced adhesion of ROS 17/2.8 cells through the blockade of alphavbeta3 integrin.	ros	51-54	coagulation factor II	Rattus norvegicus	21-29
16087680-2	2005	Previous studies have shown that v-src stimulates basal transcription of bsp in osteosarcoma (ROS 17/2.8) cells by targeting the inverted CCAAT element (ICE) in the proximal promoter.	ros	94-97	integrin-binding sialoprotein	Rattus norvegicus	73-76
16211252-0	2005	Induction of heat shock protein 72 in C6 glioma cells by methyl jasmonate through ROS-dependent heat shock factor 1 activation.	ros	82-85	heat shock protein family A (Hsp70) member 1A	Homo sapiens	13-34
16174294-4	2005	We have earlier reported that LPS/Abeta stimulation-induced ceramide and ROS generation leads to iNOS expression and nitric oxide production in glial cells.	ros	73-76	nitric oxide synthase 2	Rattus norvegicus	97-101
16210649-3	2005	In this paper we report on studies examining how the ROS hydrogen peroxide (H(2)O(2)) affects the production of MMP-1, COX-2, and PGE(2).	ros	53-56	prostaglandin-endoperoxide synthase 2	Homo sapiens	119-124
16051297-6	2005	Rhodostomin, an Arg-Gly-Asp (RGD)-containing snake venom peptide, and synthetic peptide RGDS also blocked the thrombin-enhanced ROS 17/2.8 cell adhesion.	ros	128-131	coagulation factor II	Rattus norvegicus	110-118
16082193-5	2005	Quercetin caused a downregulation of Cu-Zn Superoxide Dismutase which perhaps led to an increase of reactive oxidative stress (ROS).	ros	127-130	superoxide dismutase 1	Homo sapiens	37-63
16171436-13	2005	Gel mobility shift assays with radiolabeled FRE and transforming growth factor-beta1 (TGF-beta1) activation element (TAE) ds-oligonucleotides revealed increased binding of nuclear proteins from amelogenin-stimulated ROS 17/2.8 cells.	ros	216-219	transforming growth factor, beta 1	Rattus norvegicus	86-95
15880691-7	2005	Moreover, blockage of the MEK/ERK pathway caused a breakdown of the mitochondrial membrane potential accompanied by an elevation in the ROS production.	ros	136-139	mitogen-activated protein kinase kinase 7	Homo sapiens	26-29
15880691-7	2005	Moreover, blockage of the MEK/ERK pathway caused a breakdown of the mitochondrial membrane potential accompanied by an elevation in the ROS production.	ros	136-139	mitogen-activated protein kinase 1	Homo sapiens	30-33
15880691-8	2005	Disruption of p53 expression attenuated the depolarization of the mitochondrial membrane and ROS generation.	ros	93-96	tumor protein p53	Homo sapiens	14-17
16179514-8	2005	Together, these data indicate that LE and DTLE are neuroprotective at femtomolar concentrations through the inhibition of oxidative insult associated with microglial NADPH oxidase and the attenuation of the ROS-mediated amplification of TNFalpha gene expression in microglia.	ros	207-210	tumor necrosis factor	Homo sapiens	237-245
16184402-4	2005	We previously reported that ET-1 induces ROS generation via the ET(A) receptor and ROS modulates c-fos gene expression.	ros	41-44	endothelin 1	Rattus norvegicus	28-32
15911335-3	2005	ROS (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly(ADP-ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death.	ros	0-3	poly(ADP-ribose) polymerase 1	Homo sapiens	234-238
16142640-9	2005	Our results indicate that its ROS scavenger and IKK inhibitory activities also contribute to the suppression of ROS-mediated NF-kappaB activity.	ros	30-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
16142640-9	2005	Our results indicate that its ROS scavenger and IKK inhibitory activities also contribute to the suppression of ROS-mediated NF-kappaB activity.	ros	112-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
15917187-0	2005	ROS mediates 4HPR-induced posttranscriptional expression of the Gadd153 gene.	ros	0-3	DNA damage inducible transcript 3	Homo sapiens	64-71
15911335-3	2005	ROS (e.g., superoxide, peroxynitrite, hydroxyl radical and hydrogen peroxide) are all potential reactants capable of initiating DNA single strand breakage, with subsequent activation of the nuclear enzyme poly(ADP-ribose) synthetase (PARS), leading to eventual severe energy depletion of the cells, and necrotic-type cell death.	ros	0-3	poly(ADP-ribose) polymerase 1	Homo sapiens	205-232
15917187-3	2005	We have investigated the role of 4HPR-induced production of ROS in mediating the expression of the recently identified 4HPR-responsive gene Gadd153.	ros	60-63	DNA damage inducible transcript 3	Homo sapiens	140-147
15917187-9	2005	Our data provide the first evidence that the posttranscriptional expression of the Gadd153 gene can be regulated by ROS produced by 4HPR.	ros	116-119	DNA damage inducible transcript 3	Homo sapiens	83-90
16154954-3	2005	As CuZnSOD expression is regulated by stress steroids, the lack of SOD upregulation under chronic stress and its moderate upregulation in combined stress may lead to inefficient ROS defense and increased oxidative damage of brain tissues under the stress conditions.	ros	178-181	superoxide dismutase 1	Rattus norvegicus	3-10
16154954-3	2005	As CuZnSOD expression is regulated by stress steroids, the lack of SOD upregulation under chronic stress and its moderate upregulation in combined stress may lead to inefficient ROS defense and increased oxidative damage of brain tissues under the stress conditions.	ros	178-181	superoxide dismutase 1	Rattus norvegicus	7-10
15823556-7	2005	To understand the relationship between a decrease of SeW expression and intracellular GSH and ROS, we measured the concentration of intracellular GSH and ROS in cells treated to 1.4 microM MeHg using fluorescence based assays.	ros	94-97	selenoprotein W	Homo sapiens	53-56
15829437-1	2005	Cytochrome P4502E1 (CYP2E1) plays an important role in ROS production thus favouring accelerated membrane lipid peroxidation.	ros	55-58	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-18
15829437-1	2005	Cytochrome P4502E1 (CYP2E1) plays an important role in ROS production thus favouring accelerated membrane lipid peroxidation.	ros	55-58	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	20-26
15806174-2	2005	In the present study, radiation-induced cytochrome c release from mitochondria and activation of caspases accompanied by a decrease of mitochondrial membrane potential in Jurkat T cells were shown to be inhibited by mitochondrial complex I inhibitor rotenone, suggesting that mitochondrial ROS might be important in radiation-induced caspase-dependent apoptosis.	ros	290-293	cytochrome c, somatic	Homo sapiens	40-52
15806174-4	2005	Furthermore, activation of p38 MAP kinase by radiation was associated with radiation-induced cell death and ROS production and PKCdelta was an upstream molecule for p38 MAP kinase activation, ROS generation and subsequent caspase-dependent apoptotic events.	ros	108-111	mitogen-activated protein kinase 14	Homo sapiens	27-30
15806174-4	2005	Furthermore, activation of p38 MAP kinase by radiation was associated with radiation-induced cell death and ROS production and PKCdelta was an upstream molecule for p38 MAP kinase activation, ROS generation and subsequent caspase-dependent apoptotic events.	ros	192-195	mitogen-activated protein kinase 14	Homo sapiens	27-30
15823556-7	2005	To understand the relationship between a decrease of SeW expression and intracellular GSH and ROS, we measured the concentration of intracellular GSH and ROS in cells treated to 1.4 microM MeHg using fluorescence based assays.	ros	154-157	selenoprotein W	Homo sapiens	53-56
15855237-5	2005	In contrast to the ROS/ZO-1dn cells, ROS cells that over-expressed ZO-1 protein (ROS/ZO-1myc cells) exhibited increased gap junctional permeability and appositional membrane staining for Cx43.	ros	37-40	gap junction protein, alpha 1	Rattus norvegicus	187-191
15855237-5	2005	In contrast to the ROS/ZO-1dn cells, ROS cells that over-expressed ZO-1 protein (ROS/ZO-1myc cells) exhibited increased gap junctional permeability and appositional membrane staining for Cx43.	ros	37-40	gap junction protein, alpha 1	Rattus norvegicus	187-191
15855237-3	2005	Expression of this ZO-1(7-444) fusion protein in ROS cells disrupted the Cx43/ZO-1 interaction and decreased dye transfer by 85%, although Cx43 was retained on the plasma membrane as assessed by surface biotinylation.	ros	49-52	gap junction protein, alpha 1	Rattus norvegicus	73-77
15866424-7	2005	For instance, Ros, Cig, and PGJ2 were all potent agonist of PPARgamma transactivation in lung adenocarcinoma cell lines while these same ligands had no effect in squamous cell or large cell carcinomas of the lung.	ros	14-17	peroxisome proliferator activated receptor gamma	Homo sapiens	60-69
15866424-9	2005	The ratio of PPARgamma to RXRalpha was predictive of how cells responded to co-treatment of Ros and 9-cis-retinoic acid, an RXRalpha agonist, in two out of three cell lines tested.	ros	92-95	peroxisome proliferator activated receptor gamma	Homo sapiens	13-22
16036323-6	2005	The constriction during reperfusion after 45 min of ischemia is supposedly caused by the inhibition of Akt-mediated eNOS-Ser1177 phosphorylation, which was suppressed by a PKC inhibitor chelerythrine, or ROS scavengers N-2-mercaptopropionyl glycine (MPG) and 4,5-Dihydroxy-1, 3-benzenedisulfonic acid disodium salt (Tiron).	ros	204-207	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
16028366-6	2005	It is concluded that T3-induced oxidative stress triggers the redox upregulation of liver iNOS expression through a cascade initiated by TNF-a produced by Kupffer cells and involving Ikappa-alpha phosphorylation and NF-kappaB activation, a response that may represent a defense mechanism by protecting the liver from cytokine-mediated lethality and ROS toxicity.	ros	349-352	nitric oxide synthase 2	Rattus norvegicus	90-94
15591411-6	2005	Rac1 and RhoA rapidly respond to changes in oxygen tension, and their activity depends on NADPH oxidase- and PI3 kinase-dependent production of ROS.	ros	144-147	ras homolog family member A	Homo sapiens	9-13
15780757-9	2005	In conclusion, Nox 2 stimulates muscle differentiation downstream of the PI 3-kinase/p38 MAPK pathway by activating the NF-kappaB/iNOS pathway via ROS generation.	ros	147-150	nuclear factor kappa B subunit 1	Homo sapiens	120-129
15692809-11	2005	CONCLUSIONS/INTERPRETATION: The unusual resistance of ALR mice to both ROS-mediated and autoimmune type 1 diabete stresses reflects an interaction between the nuclear and mt genomes.	ros	71-74	growth factor, augmenter of liver regeneration	Mus musculus	54-57
15832818-0	2005	Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta.	ros	62-65	nitric oxide synthase 2	Rattus norvegicus	43-47
15832818-0	2005	Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta.	ros	62-65	tumor necrosis factor	Rattus norvegicus	94-103
15832818-0	2005	Agastache rugosa leaf extract inhibits the iNOS expression in ROS 17/2.8 cells activated with TNF-alpha and IL-1beta.	ros	62-65	interleukin 1 beta	Rattus norvegicus	108-116
15832818-5	2005	A preincubation with ELAR significantly and concentration-dependently reduced the expression of iNOS protein in ROS 17/2.8 cells activated with the cytokine mixture.	ros	112-115	nitric oxide synthase 2	Rattus norvegicus	96-100
15703842-6	2005	The data provide evidence that BCL-2 protein could protect HL-60 VCR from mitochondrial membrane depolarization and block ROS production in these cells.	ros	122-125	BCL2 apoptosis regulator	Homo sapiens	31-36
15592513-3	2005	Here, we demonstrate that hydrogen peroxide (H2O2) upregulates the expression of Bfl-1, an antiapoptotic member of the Bcl-2 family, and that this is responsible for the antiapoptotic activity of ROS.	ros	196-199	BCL2 related protein A1	Homo sapiens	81-86
15592513-3	2005	Here, we demonstrate that hydrogen peroxide (H2O2) upregulates the expression of Bfl-1, an antiapoptotic member of the Bcl-2 family, and that this is responsible for the antiapoptotic activity of ROS.	ros	196-199	BCL2 apoptosis regulator	Homo sapiens	119-124
15780950-6	2005	The transient exposure of ROS 17/2.8 cells to H2O2 (100 microM) was found to elevate FKBP12 mRNA after 10 min and protein expression after 24 h. Both PTH (10(-9) M) and 1,25 (OH)2D3 (Vitamin D3) (10(-7) M) suppressed FKBP12 protein expression.	ros	26-29	parathyroid hormone	Rattus norvegicus	150-153
15780950-0	2005	Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells.	ros	117-120	RUNX family transcription factor 2	Rattus norvegicus	96-101
15665518-0	2005	Atrial natriuretic peptide effects on intracellular pH changes and ROS production in HEPG2 cells: role of p38 MAPK and phospholipase D. AIMS: The present study was performed to evaluate Atrial Natriuretic Peptide (ANP) effects on intracellular pH, phospholipase D and ROS production and the possible relationship among them in HepG2 cells.	ros	67-70	natriuretic peptide A	Homo sapiens	0-26
15834660-3	2005	Caloric restriction during 6 weeks decreased ROS generation and oxidative DNA damage in heart mitochondria and this was reversed by insulin treatment.	ros	45-48	insulin	Homo sapiens	132-139
15834660-5	2005	In the liver, however, insulin and GH decreased mitochondrial ROS generation while they increased oxidative damage to mitochondrial DNA.	ros	62-65	insulin	Homo sapiens	23-30
15665518-6	2005	RESULTS: A significant pHi decrease was observed in ANP-treated HepG2 cells and this effect was paralleled by the enhancement of PLD activity and ROS production.	ros	146-149	natriuretic peptide A	Homo sapiens	52-55
15665518-8	2005	Moreover, the relationship between PLD and ROS production was demonstrated by calphostin-c, a potent inhibitor of PLD.	ros	43-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	35-38
15665518-8	2005	Moreover, the relationship between PLD and ROS production was demonstrated by calphostin-c, a potent inhibitor of PLD.	ros	43-46	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	114-117
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	124-127	natriuretic peptide A	Homo sapiens	38-41
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	124-127	mitogen-activated protein kinase 14	Homo sapiens	84-87
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	124-127	solute carrier family 9 member A1	Homo sapiens	94-99
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	124-127	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	124-127	natriuretic peptide A	Homo sapiens	171-174
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	197-200	natriuretic peptide A	Homo sapiens	38-41
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	197-200	mitogen-activated protein kinase 14	Homo sapiens	84-87
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	197-200	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	104-107
15665518-10	2005	CONCLUSION: Our results indicate that ANP recruits a signal pathway associated with p38 MAPK, NHE-1 and PLD responsible for ROS production, suggesting a possible role for ANP as novel modulator of ROS generation in HepG2 cells.	ros	197-200	natriuretic peptide A	Homo sapiens	171-174
15581626-3	2004	Inhibition of NF-kappaB activation resulted in an increase in TNFalpha-induced ROS production, lipid peroxidation and protein oxidation.	ros	79-82	nuclear factor kappa B subunit 1	Homo sapiens	14-23
15581626-4	2004	Those ROS and lipid peroxides were both involved in TNFalpha-induced apoptosis, whereas only ROS elevation triggered sustained JNK activation.	ros	6-9	tumor necrosis factor	Homo sapiens	52-60
15724436-6	2005	These findings suggested that GRP75 could inhibit the ROS accumulation, and it may be associated with the cytoprotective effect of GRP75 overexpression upon glucose deprivation.	ros	54-57	heat shock protein family A (Hsp70) member 9	Rattus norvegicus	30-35
15581626-4	2004	Those ROS and lipid peroxides were both involved in TNFalpha-induced apoptosis, whereas only ROS elevation triggered sustained JNK activation.	ros	93-96	mitogen-activated protein kinase 8	Homo sapiens	127-130
15581626-3	2004	Inhibition of NF-kappaB activation resulted in an increase in TNFalpha-induced ROS production, lipid peroxidation and protein oxidation.	ros	79-82	tumor necrosis factor	Homo sapiens	62-70
15364949-6	2004	ROS could indeed be detected in IL-8-stimulated beta-arrestin 1/2 knockout cells, and cytoplasmic Rac was translocated to the membrane fraction, which is a prerequisite for oxidant formation.	ros	0-3	C-X-C motif chemokine ligand 8	Homo sapiens	32-36
15364949-6	2004	ROS could indeed be detected in IL-8-stimulated beta-arrestin 1/2 knockout cells, and cytoplasmic Rac was translocated to the membrane fraction, which is a prerequisite for oxidant formation.	ros	0-3	arrestin beta 1	Homo sapiens	48-63
15804829-5	2004	Cygb is linked to collagen synthesis, may provide O2 for enzymatic reactions, and may be involved in a ROS(NO)-signaling pathway(s).	ros	103-106	cytoglobin	Homo sapiens	0-4
15226155-0	2004	EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death.	ros	97-100	epidermal growth factor receptor	Homo sapiens	0-4
15226155-0	2004	EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death.	ros	97-100	mitogen-activated protein kinase 1	Homo sapiens	31-34
15226155-0	2004	EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death.	ros	97-100	epidermal growth factor receptor	Homo sapiens	44-48
15226155-0	2004	EGFR-independent activation of p38 MAPK and EGFR-dependent activation of ERK1/2 are required for ROS-induced renal cell death.	ros	97-100	mitogen-activated protein kinase 3	Homo sapiens	73-79
15868480-13	2004	ROS also reduced viability, but this was observed only after both cytochrome P450 stimulation and catalase inhibition.	ros	0-3	catalase	Homo sapiens	66-106
15130759-12	2004	However, JNK activation by ROS is not involved in the tetrandrine-induced apoptosis.	ros	27-30	mitogen-activated protein kinase 8	Homo sapiens	9-12
15342787-8	2004	Transient transfection of constructs containing various sequences of the Cx43 promoter tagged to a LacZ reporter into ROS 17/2.8 cells confirmed that the promoter region between -838 to -1693 was deemed necessary for CNTF-CNTFRalpha to induce heightened expression.	ros	118-121	gap junction protein, alpha 1	Rattus norvegicus	73-77
15328028-7	2004	Our results suggest that (1) higher concentration of S100beta in the extracellular space due to S100beta leakage from damaged astrocytes leads to up-regulation of S100beta synthesis and induction of inducible nitric oxide synthase (iNOS) synthesis in astrocytes, contributing to infarct expansion that results in DNA damage or cell death via NO and ROS production, and (2) GFAP, but not S100beta, is a main contributor to glial scar formation.	ros	349-352	S100 calcium binding protein B	Homo sapiens	53-61
15328028-7	2004	Our results suggest that (1) higher concentration of S100beta in the extracellular space due to S100beta leakage from damaged astrocytes leads to up-regulation of S100beta synthesis and induction of inducible nitric oxide synthase (iNOS) synthesis in astrocytes, contributing to infarct expansion that results in DNA damage or cell death via NO and ROS production, and (2) GFAP, but not S100beta, is a main contributor to glial scar formation.	ros	349-352	S100 calcium binding protein B	Homo sapiens	96-104
15328028-7	2004	Our results suggest that (1) higher concentration of S100beta in the extracellular space due to S100beta leakage from damaged astrocytes leads to up-regulation of S100beta synthesis and induction of inducible nitric oxide synthase (iNOS) synthesis in astrocytes, contributing to infarct expansion that results in DNA damage or cell death via NO and ROS production, and (2) GFAP, but not S100beta, is a main contributor to glial scar formation.	ros	349-352	S100 calcium binding protein B	Homo sapiens	96-104
15328028-7	2004	Our results suggest that (1) higher concentration of S100beta in the extracellular space due to S100beta leakage from damaged astrocytes leads to up-regulation of S100beta synthesis and induction of inducible nitric oxide synthase (iNOS) synthesis in astrocytes, contributing to infarct expansion that results in DNA damage or cell death via NO and ROS production, and (2) GFAP, but not S100beta, is a main contributor to glial scar formation.	ros	349-352	S100 calcium binding protein B	Homo sapiens	96-104
15517871-4	2004	There was no significant difference in the potency of the mouse, chimera, or the humanized antibodies to suppress the PTHrP-induced increase in the intracellular cAMP in ROS cells.	ros	170-173	parathyroid hormone-like peptide	Mus musculus	118-123
15197348-5	2004	The reduction in cell growth and enhancement in cell killing by the combination of GST-MDA-7 and radiation were blocked by an ROS scavenger, N-acetyl cysteine (NAC), a JNK1/2/3 inhibitor SP600125, a pan-caspase inhibitor (zVAD) and by an inhibitor of caspase 9 (LEHD), but not by an inhibitor of caspase 8 (IETD).	ros	126-129	mitogen-activated protein kinase 8	Homo sapiens	168-176
15030176-6	2004	OxLDL modulated ROS production not only of resting PMN but also that of activated PMN, as indicated by a 14-fold increase in FMLP-stimulated CL response and a 50% decrease in zymosan-mediated CL answer.	ros	16-19	formyl peptide receptor 1	Homo sapiens	125-129
15209356-0	2004	N-acetyl cysteine regulates TNF-alpha-inhibited differentiation in ROS 17/2.8 osteoblasts.	ros	67-70	tumor necrosis factor	Rattus norvegicus	28-37
15209356-2	2004	The alkaline phosphatase (ALPase) activity was decreased in ROS 17/2.8 osteoblast treated with TNF-alpha (2, 5 or 10 ng/ml).	ros	60-63	tumor necrosis factor	Rattus norvegicus	95-104
15209356-3	2004	The treatment of TNF-alpha inhibited osteoblast differentiation such as ALPase activity in ROS 17/2.8 osteoblast.	ros	91-94	tumor necrosis factor	Rattus norvegicus	17-26
15280077-9	2004	ACTH-(1-24) plus dextrans 70/500 increased MAP immediately; it increased vasodilation and PCL, and attenuated significantly ROS production and leukocyte adhesion during resuscitation.	ros	124-127	proopiomelanocortin	Homo sapiens	0-4
15019093-6	2004	These results suggest that PM2.5 induces NFkappaB activity via the pathways involving ROS and/or RNS generation.	ros	86-89	nuclear factor kappa B subunit 1	Homo sapiens	41-49
14999093-5	2004	In rat ROS 17/2.8 cells, osteocalcin and Col1a1 gene expression was reduced up to 90% by the U1 anti-osteocalcin or U1 anti-Col1a1 construct, respectively.	ros	7-10	bone gamma-carboxyglutamate protein	Rattus norvegicus	25-36
14999093-5	2004	In rat ROS 17/2.8 cells, osteocalcin and Col1a1 gene expression was reduced up to 90% by the U1 anti-osteocalcin or U1 anti-Col1a1 construct, respectively.	ros	7-10	collagen type I alpha 1 chain	Rattus norvegicus	41-47
14999093-5	2004	In rat ROS 17/2.8 cells, osteocalcin and Col1a1 gene expression was reduced up to 90% by the U1 anti-osteocalcin or U1 anti-Col1a1 construct, respectively.	ros	7-10	bone gamma-carboxyglutamate protein	Rattus norvegicus	101-112
14999093-5	2004	In rat ROS 17/2.8 cells, osteocalcin and Col1a1 gene expression was reduced up to 90% by the U1 anti-osteocalcin or U1 anti-Col1a1 construct, respectively.	ros	7-10	collagen type I alpha 1 chain	Rattus norvegicus	124-130
14739767-8	2004	In addition, inflammatory cytokines and ROS lead to decreased TIMP levels and collagen synthesis.	ros	40-43	TIMP metallopeptidase inhibitor 1	Homo sapiens	62-66
14757701-10	2004	Cholinergic antagonist mecamylamine inhibited nicotine-induced protection against A beta-induced caspase-3 activation and ROS accumulation.	ros	122-125	amyloid beta precursor protein	Homo sapiens	82-88
15106733-7	2004	In addition, TNF-alpha/IFN-gamma stimulated ROS release in the osteoblasts.	ros	44-47	tumor necrosis factor	Homo sapiens	13-22
15106733-7	2004	In addition, TNF-alpha/IFN-gamma stimulated ROS release in the osteoblasts.	ros	44-47	interferon gamma	Homo sapiens	23-32
15068114-6	2004	RESULTS: Using the osteoblastic cell line ROS 17/2.8, we determined that BSP mRNA levels increased approximately 2.8-fold by EMD.	ros	42-45	integrin-binding sialoprotein	Rattus norvegicus	73-76
14660625-9	2004	rho(0) cells were resistant to p53, and intracellular ROS contents after p53 expression were lower compared with parental cells.	ros	54-57	tumor protein p53	Homo sapiens	73-76
14674678-4	2003	In outer segments, ROS-GCs sense fluctuations in Ca(2+) via two Ca(2+)-binding proteins, which have been termed GCAP1 and GCAP2.	ros	19-22	guanylate cyclase activator 1A	Homo sapiens	112-117
14597125-8	2003	When potentiation of DON-induced apoptosis by TNF-alpha was assessed using pharmacological inhibitors, generation of ROS, intracellular Ca2+, p38/SAPK, and caspase-3 activation were found to play roles.	ros	117-120	tumor necrosis factor	Mus musculus	46-55
14572603-9	2003	From the results based on an in vitro leukocyte differentiation model, we speculated that the antioxidant effect of the COX-2 inhibitors might be partly associated with both counteraction of proinflammatory cytokine-enhanced ROS generation and inhibition of CD11b, an important molecule for cell adhesion, expression.	ros	225-228	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
14617790-6	2003	Bcl-2, an inhibitor of apoptosis, is shown to regulate ROS generation.	ros	55-58	BCL2, apoptosis regulator	Rattus norvegicus	0-5
14617790-8	2003	Overexpression of Bcl-2 inhibited the production of ROS in phycocyanin-treated AK-5 cells.	ros	52-55	BCL2, apoptosis regulator	Rattus norvegicus	18-23
14711010-5	2003	This review will cover some aspects of the involvement of ROS- and RNS-mediated apoptotic processes occurring in cellular models of familial amyotrophic lateral sclerosis (FALS), in particular the cases associated with mutations in SOD1, the gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD).	ros	58-61	superoxide dismutase 1	Homo sapiens	232-236
14556853-6	2003	We propose that Yap1 has two distinct molecular redox centers, one triggered by ROS (hydroperoxides and the superoxide anion) and the other by chemicals with thiol reactivity (electrophiles and divalent heavy metals cations).	ros	80-83	DNA-binding transcription factor YAP1	Saccharomyces cerevisiae S288C	16-20
14556859-2	2003	Introduction of Bcl-2 gene in BC-8 cells inhibited hypothermia-induced apoptotic process, which is ascribed to reduced ROS generation and higher glutathione production.	ros	119-122	BCL2 apoptosis regulator	Homo sapiens	16-21
14703801-7	2003	Incubation of apoferritin with AA (2.5-50 mM, after 6 h) changes the apoprotein electrophoretic behavior, suggesting a structural modification of the apoprotein by AA-generated ROS.	ros	177-180	ferritin heavy chain	Equus caballus	14-25
14711010-5	2003	This review will cover some aspects of the involvement of ROS- and RNS-mediated apoptotic processes occurring in cellular models of familial amyotrophic lateral sclerosis (FALS), in particular the cases associated with mutations in SOD1, the gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD).	ros	58-61	superoxide dismutase 1	Homo sapiens	256-282
14711010-5	2003	This review will cover some aspects of the involvement of ROS- and RNS-mediated apoptotic processes occurring in cellular models of familial amyotrophic lateral sclerosis (FALS), in particular the cases associated with mutations in SOD1, the gene encoding Cu,Zn superoxide dismutase (Cu,Zn SOD).	ros	58-61	superoxide dismutase 1	Homo sapiens	284-293
12962720-1	2003	OBJECTIVE: Patients with myelodysplasia (MDS) show a disturbed production of ROS in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) in granulocyte-macrophage colony-stimulating factor (GM-CSF)-primed neutrophils.	ros	77-80	formyl peptide receptor 1	Homo sapiens	143-147
14614324-8	2003	Together, these findings support a model in which induction of apoptosis in Bcr/Abl+ cells by HDIs involves coordinate inactivation of the cytoprotective Raf/MEK/ERK pathway in conjunction with the ROS-dependent activation of JNK.	ros	198-201	mitogen-activated protein kinase 8	Homo sapiens	226-229
12962720-9	2003	CONCLUSION: Our results indicate both a lower basal protein level and a disturbed fMLP-induced increase in plasma membrane expression of flavocytochrome b558 in neutrophils from MDS patients, which together might play a role in decreased ROS production.	ros	238-241	formyl peptide receptor 1	Homo sapiens	82-86
12799643-6	2003	Cyclin E-overexpressing fibroblasts also displayed a reduction in ROS levels and a significantly lower increase following doxorubicin treatment compared with vector control cells.	ros	66-69	cyclin E1	Rattus norvegicus	0-8
12663441-5	2003	Furthermore, Ang II induced a robust phosphorylation of p38MAPK, ERK1/2, and JNK1/2 (particularly JNK2), which was hindered by inhibitors of NADPH oxidase, tyrosine kinases, and ROS scavengers.	ros	178-181	angiotensinogen	Homo sapiens	13-19
12663441-5	2003	Furthermore, Ang II induced a robust phosphorylation of p38MAPK, ERK1/2, and JNK1/2 (particularly JNK2), which was hindered by inhibitors of NADPH oxidase, tyrosine kinases, and ROS scavengers.	ros	178-181	mitogen-activated protein kinase 8	Homo sapiens	77-83
12663441-5	2003	Furthermore, Ang II induced a robust phosphorylation of p38MAPK, ERK1/2, and JNK1/2 (particularly JNK2), which was hindered by inhibitors of NADPH oxidase, tyrosine kinases, and ROS scavengers.	ros	178-181	mitogen-activated protein kinase 9	Homo sapiens	98-102
12663441-7	2003	Present data demonstrate for the first time a stimulatory role of Ang II in the activation of phagocytic cells, underscore the relevant role of ROS as mediators in this process, and uncover a variety of signaling pathways by which Ang II operates in human neutrophils.	ros	144-147	angiotensinogen	Homo sapiens	66-72
12663441-7	2003	Present data demonstrate for the first time a stimulatory role of Ang II in the activation of phagocytic cells, underscore the relevant role of ROS as mediators in this process, and uncover a variety of signaling pathways by which Ang II operates in human neutrophils.	ros	144-147	angiotensinogen	Homo sapiens	231-237
12895587-10	2003	ROS 17/2.8 rat osteosarcoma cells submitted to sequential deformations responded faster than other cell lines by increasing their ALP activity only after 1 day of stretching.	ros	0-3	alkaline phosphatase, placental	Homo sapiens	130-133
12880425-5	2003	Generation of ROS and hyperpolarization of mitochondrial transmembrane potential (DeltaPsim) were early events, followed by increased Fas expression and activation of caspase-8, and then activation of caspase-3 and -9.	ros	14-17	caspase 3	Homo sapiens	201-217
12753864-9	2003	PTHrP maximally induced ICER mRNA at 2-4 h, which then returned to baseline by 10 h. Finally, PTH, FSK, and PTHrP induced ICER in cultured mouse calvariae and osteoblastic ROS 17/2.8, UMR-106, and Pyla cells.	ros	172-175	parathyroid hormone-like peptide	Mus musculus	0-5
12765953-3	2003	Herein, we show that bcl-2-overexpressing cells are resistant to the cytotoxic effects of reactive oxygen and nitrogen species (ROS/RNS), but are only modestly protected against high concentrations of IL-1beta + INF-gamma, whereas the converse is true in cytokine selected cells.	ros	128-131	BCL2, apoptosis regulator	Rattus norvegicus	21-26
12753864-9	2003	PTHrP maximally induced ICER mRNA at 2-4 h, which then returned to baseline by 10 h. Finally, PTH, FSK, and PTHrP induced ICER in cultured mouse calvariae and osteoblastic ROS 17/2.8, UMR-106, and Pyla cells.	ros	172-175	parathyroid hormone-like peptide	Mus musculus	108-113
12678687-4	2003	Among recent advances are the discoveries that reactive nitrogen species (RNS), oxygen species (ROS), cytokines, and growth factors participate in stability regulation of HIF-1alpha and HIF-1 transactivation during normoxia.	ros	96-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-181
12733958-6	2003	RESULTS: The ROS 17/2.8 cells transfected with antisense Tbx2 showed a decrease in expression of Tbx2 protein and an increase in expression of endogenous Cx43.	ros	13-16	gap junction protein, alpha 1	Rattus norvegicus	154-158
12678687-4	2003	Among recent advances are the discoveries that reactive nitrogen species (RNS), oxygen species (ROS), cytokines, and growth factors participate in stability regulation of HIF-1alpha and HIF-1 transactivation during normoxia.	ros	96-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	171-176
12818404-2	2003	Myeloperoxidase (MPO) has been shown to contribute to several diseases and more particularly to atherosclerosis through excessive ROS production via the MPO/H(2)O(2)/Cl(-) oxidation system.	ros	130-133	myeloperoxidase	Homo sapiens	0-15
12697419-11	2003	Between 150 and 240 min of light adaptation the arrestin-GFP in the ROS gradually declined until the pattern of arrestin-GFP localization was indistinguishable from that of dark-adapted photoreceptors.	ros	68-71	S-antigen; retina and pineal gland (arrestin) L homeolog	Xenopus laevis	48-56
12914297-2	2003	At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis; 3) ROS mediated DNA damage and P53 activation; 4) ROS activated SAPK pathway to apoptosis.	ros	187-190	mitogen-activated protein kinase 9	Homo sapiens	248-252
12914297-2	2003	At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis; 3) ROS mediated DNA damage and P53 activation; 4) ROS activated SAPK pathway to apoptosis.	ros	187-190	mitogen-activated protein kinase 9	Homo sapiens	248-252
12818404-2	2003	Myeloperoxidase (MPO) has been shown to contribute to several diseases and more particularly to atherosclerosis through excessive ROS production via the MPO/H(2)O(2)/Cl(-) oxidation system.	ros	130-133	myeloperoxidase	Homo sapiens	17-20
12818404-2	2003	Myeloperoxidase (MPO) has been shown to contribute to several diseases and more particularly to atherosclerosis through excessive ROS production via the MPO/H(2)O(2)/Cl(-) oxidation system.	ros	130-133	myeloperoxidase	Homo sapiens	153-156
12599206-5	2003	In particular, ROS recruited p38MAPK and JNK pathways.	ros	15-18	mitogen-activated protein kinase 8	Homo sapiens	41-44
12554783-2	2003	Here, we investigate the chromatin-mediated mechanisms by which the bone-specific osteocalcin (OC) gene is transcriptionally activated during cessation of cell growth in ROS 17/2.8 osteosarcoma cells and during normal osteoblast differentiation.	ros	170-173	bone gamma-carboxyglutamate protein	Rattus norvegicus	82-93
12554783-2	2003	Here, we investigate the chromatin-mediated mechanisms by which the bone-specific osteocalcin (OC) gene is transcriptionally activated during cessation of cell growth in ROS 17/2.8 osteosarcoma cells and during normal osteoblast differentiation.	ros	170-173	bone gamma-carboxyglutamate protein	Rattus norvegicus	95-97
12554783-5	2003	Active expression of the OC gene in mature osteoblasts and confluent ROS 17/2.8 cells is functionally linked to preferential acetylation of histone H4 and, to a lesser extent, to acetylation of histone H3.	ros	69-72	bone gamma-carboxyglutamate protein	Rattus norvegicus	25-27
14681058-6	2003	To evaluate whether the proliferation (stretch) or survival (relaxed) status of ROS cells influences focal contact organization, we inhibited the ERK proliferative-dependent pathway.	ros	80-83	Eph receptor B1	Rattus norvegicus	146-149
12582204-4	2003	In contrast, by using methods that detect extracellular ROS, specificity can be corroborated by adding the appropriate competitor; for example, superoxide dismutase competes for superoxide, and catalase competes for H(2)O(2).	ros	56-59	catalase	Homo sapiens	194-202
12614848-5	2003	Reducing reagents/reactive oxygen species (ROS) scavengers reduced arsenite-induced Akt phosphorylation and beta cyclodextrin reduced arsenite-mediated ROS production, suggesting that arsenite-induced G-protein/Akt/GSK3beta pathway is membrane raft dependent and redox linked.	ros	43-46	AKT serine/threonine kinase 1	Homo sapiens	84-87
12603823-4	2003	H19-7 cells overexpressing bcl-2 were found to be resistant to ROS-induced apoptosis.	ros	63-66	BCL2, apoptosis regulator	Rattus norvegicus	27-32
12603823-6	2003	In the present study, we demonstrate that ROS decreases the activity of luciferase reporter gene driven by a cyclic AMP response element site containing bcl-2 promoter.	ros	42-45	BCL2, apoptosis regulator	Rattus norvegicus	153-158
12952182-4	2003	To determine the molecular mechanism of FGF2 regulation of osteogenesis, we have analyzed the effects of FGF2 on the expression of BSP in the rat osteosarcoma cell line ROS 17/2.8.	ros	169-172	integrin-binding sialoprotein	Rattus norvegicus	131-134
12581340-3	2003	Hydrogen peroxide, a by-product of ROS generation, is a chemical inducer of gene expression able to activate apoptosis and to promote the antioxidant response through the activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factor.	ros	35-38	nuclear factor kappa B subunit 1	Homo sapiens	185-207
12414803-4	2003	The inhibitory effects of PD169316 are mimicked by the antioxidant GSH, suggesting a role for reactive oxygenated species (ROS) generation in the increase of UCP-1 expression in response either to Rosi or 9-cis-retinoic acid.	ros	123-126	uncoupling protein 1	Rattus norvegicus	158-163
12392766-13	2002	Synaptosomes from APOE knock-out mice are more vulnerable to Abeta-induced oxidative stress (protein oxidation, lipid peroxidation, and ROS generation) than are those from wild-type mice.	ros	136-139	apolipoprotein E	Mus musculus	18-22
12493091-11	2002	In vivo inhibition of iNOS or ODC decreased ROS production induced by GLN and ARG.	ros	44-47	nitric oxide synthase 2	Rattus norvegicus	22-26
12372804-2	2002	We confirmed that these mRNAs are transiently stimulated by parathyroid hormone (PTH) in ROS 17/2.8 osteoblastic cells.	ros	89-92	parathyroid hormone	Rattus norvegicus	60-79
12372804-2	2002	We confirmed that these mRNAs are transiently stimulated by parathyroid hormone (PTH) in ROS 17/2.8 osteoblastic cells.	ros	89-92	parathyroid hormone	Rattus norvegicus	81-84
12470896-8	2002	Age-related increases in redox-sensitive NF-kappaB, AP-1, and HIF-1 binding activities are concluded to be associated with increased ROS and CR to modulate their activations by suppressing oxidative stress.	ros	133-136	nuclear factor kappa B subunit 1	Homo sapiens	41-50
12470896-8	2002	Age-related increases in redox-sensitive NF-kappaB, AP-1, and HIF-1 binding activities are concluded to be associated with increased ROS and CR to modulate their activations by suppressing oxidative stress.	ros	133-136	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	52-56
12470896-8	2002	Age-related increases in redox-sensitive NF-kappaB, AP-1, and HIF-1 binding activities are concluded to be associated with increased ROS and CR to modulate their activations by suppressing oxidative stress.	ros	133-136	hypoxia inducible factor 1 subunit alpha	Homo sapiens	62-67
12193549-9	2002	Overexpression of deltaEF1 in ROS 17/2.8 cells led to an 84% decrease in osteocalcin mRNA levels relative to cells transfected with empty vector, confirming that deltaEF1 suppresses expression of the endogenous osteocalcin gene.	ros	30-33	bone gamma-carboxyglutamate protein	Rattus norvegicus	73-84
12193549-9	2002	Overexpression of deltaEF1 in ROS 17/2.8 cells led to an 84% decrease in osteocalcin mRNA levels relative to cells transfected with empty vector, confirming that deltaEF1 suppresses expression of the endogenous osteocalcin gene.	ros	30-33	bone gamma-carboxyglutamate protein	Rattus norvegicus	211-222
12607822-13	2002	Synaptosomes from apoE knock-out mice are more vulnerable to Abeta-induced oxidative stress (protein oxidation, lipid peroxidation, and ROS generation) than are those from wild-type mice.	ros	136-139	apolipoprotein E	Mus musculus	18-22
12151057-10	2002	In contrast, pretreatment with millimolar dose of ASC or NAC maintained an elevated mitogenicity in response to insulin irrespective of the ROS/RNS donor type used.	ros	140-143	PYD and CARD domain containing	Homo sapiens	50-53
12151316-8	2002	Herein we present a novel action of proteasome inhibitors, possibly through ROS production, of targeting the upstream signaling molecules, ERK and JNK, which leads to AP-1 activation and IL-8 gene expression.	ros	76-79	mitogen-activated protein kinase 1	Homo sapiens	139-142
12151057-2	2002	ROS/RNS inhibited insulin-induced mitogenicity (DNA synthesis).	ros	0-3	insulin	Homo sapiens	18-25
12151057-6	2002	Taken together, these results have shown that ROS/RNS provide a good explanation for the developing resistance to the growth promoting activity of insulin in myoblasts under conditions of oxidative or nitrosative stress.	ros	46-49	insulin	Homo sapiens	147-154
12151316-8	2002	Herein we present a novel action of proteasome inhibitors, possibly through ROS production, of targeting the upstream signaling molecules, ERK and JNK, which leads to AP-1 activation and IL-8 gene expression.	ros	76-79	mitogen-activated protein kinase 8	Homo sapiens	147-150
12151316-8	2002	Herein we present a novel action of proteasome inhibitors, possibly through ROS production, of targeting the upstream signaling molecules, ERK and JNK, which leads to AP-1 activation and IL-8 gene expression.	ros	76-79	C-X-C motif chemokine ligand 8	Homo sapiens	187-191
12361722-7	2002	This data suggest that oxidative stress and the production of ROS/RNS function as physiological regulators of ERalpha and ERbeta expression.	ros	62-65	estrogen receptor 1	Homo sapiens	110-117
12099276-0	2002	TGF-beta1 secretion of ROS-17/2.8 cultures on NiTi implant material.	ros	23-26	transforming growth factor, beta 1	Rattus norvegicus	0-9
12099276-7	2002	In this study, we measured the levels of TGF-beta with enzyme-linked immunosorbent assay (ELISA) from a ROS-17/2.8 osteosarcoma cell line cultured on different metal alloy discs.	ros	104-107	transforming growth factor, beta 1	Rattus norvegicus	41-49
12099276-19	2002	We conclude that a rough NiTi surface promotes TGF-beta1 expression in ROS-17/2.8 cells.	ros	71-74	transforming growth factor, beta 1	Rattus norvegicus	47-56
12064806-2	2002	ROS may activate certain transcription factors such as nuclear factor kappa beta (NF-kappaB), which regulates cyclooxygenase-2 (COX-2).	ros	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	110-126
12064806-2	2002	ROS may activate certain transcription factors such as nuclear factor kappa beta (NF-kappaB), which regulates cyclooxygenase-2 (COX-2).	ros	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	128-133
15344324-7	2002	Thus the inhibition of tumor invasion by Asc2P6Plm was shown to be attributed to decreases in both the cell migratory ability and the F-actin localization near the cell membrane, which may result from an increase in RhoA in the cell nucleus and reduction of intracellular ROS that is achieved by enrichment of intracellular Asc derived from Asc2P6Plm.	ros	272-275	PYD and CARD domain containing	Homo sapiens	41-44
11815388-0	2002	Redox/ROS regulation of lipopolysaccharide-induced mitogen-activated protein kinase (MAPK) activation and MAPK-mediated TNF-alpha biosynthesis.	ros	6-9	tumor necrosis factor	Homo sapiens	120-129
11948463-4	2002	Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs.	ros	175-178	interferon gamma	Homo sapiens	14-23
11900492-3	2002	Our data showed that expression of Runx2 was downregulated by VD3 within 24 h in MC3T3 and ROS 17/2.8, but not in ROS 24.1 cells, which lack a functional vitamin D receptor (VDR).	ros	91-94	RUNX family transcription factor 2	Rattus norvegicus	35-40
11799110-0	2002	The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.	ros	76-79	signal transducer and activator of transcription 3	Mus musculus	67-72
15758457-13	2002	A relatively high density of nanomolar affinity 5-HTT binding sites is present in ROS 17/2.8 and UMR 106-H5 cells.	ros	82-85	solute carrier family 6 (neurotransmitter transporter, serotonin), member 4	Mus musculus	48-53
11814331-3	2002	Lead (5-20 microM) blocked the stimulating effects of vitamin D3 on osteocalcin production in cultured rat osteosarcoma cells (ROS 17/2.8).	ros	127-130	bone gamma-carboxyglutamate protein	Rattus norvegicus	68-79
11814331-5	2002	Treatment of ROS cells with Go6976, an inhibitor of PKC alpha and beta isozymes, produced similar effects as lead on vitamin D3-dependent osteocalcin production, while activation of PKC by phorbol-12-myristate-13-acetate (TPA) did not reverse or mimic this effect of lead.	ros	13-16	protein kinase C alpha	Homo sapiens	52-61
11814331-5	2002	Treatment of ROS cells with Go6976, an inhibitor of PKC alpha and beta isozymes, produced similar effects as lead on vitamin D3-dependent osteocalcin production, while activation of PKC by phorbol-12-myristate-13-acetate (TPA) did not reverse or mimic this effect of lead.	ros	13-16	bone gamma-carboxyglutamate protein	Homo sapiens	138-149
11814331-5	2002	Treatment of ROS cells with Go6976, an inhibitor of PKC alpha and beta isozymes, produced similar effects as lead on vitamin D3-dependent osteocalcin production, while activation of PKC by phorbol-12-myristate-13-acetate (TPA) did not reverse or mimic this effect of lead.	ros	13-16	proline rich transmembrane protein 2	Homo sapiens	52-55
11814331-5	2002	Treatment of ROS cells with Go6976, an inhibitor of PKC alpha and beta isozymes, produced similar effects as lead on vitamin D3-dependent osteocalcin production, while activation of PKC by phorbol-12-myristate-13-acetate (TPA) did not reverse or mimic this effect of lead.	ros	13-16	plasminogen activator, tissue type	Homo sapiens	222-225
11948463-4	2002	Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs.	ros	175-178	epithelial cell adhesion molecule	Homo sapiens	79-84
11948463-4	2002	Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs.	ros	175-178	epithelial cell adhesion molecule	Homo sapiens	118-123
11948463-4	2002	Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs.	ros	175-178	tumor necrosis factor	Homo sapiens	183-192
11799110-4	2002	Parallel and downstream components of PI3K signaling such as the Rho family GTPases (Rac, Rho, Cdc42) and the survival factor Akt were all shown to contribute to Ros-induced anchorage-independent growth, although Rac appeared to be less important for Ros-induced colony formation in NIH3T3 cells.	ros	162-165	thymoma viral proto-oncogene 1	Mus musculus	85-88
11799110-4	2002	Parallel and downstream components of PI3K signaling such as the Rho family GTPases (Rac, Rho, Cdc42) and the survival factor Akt were all shown to contribute to Ros-induced anchorage-independent growth, although Rac appeared to be less important for Ros-induced colony formation in NIH3T3 cells.	ros	162-165	thymoma viral proto-oncogene 1	Mus musculus	126-129
11799110-4	2002	Parallel and downstream components of PI3K signaling such as the Rho family GTPases (Rac, Rho, Cdc42) and the survival factor Akt were all shown to contribute to Ros-induced anchorage-independent growth, although Rac appeared to be less important for Ros-induced colony formation in NIH3T3 cells.	ros	162-165	thymoma viral proto-oncogene 1	Mus musculus	213-216
11799110-5	2002	Furthermore, the transformation-attenuated v-Ros mutants F419 and DI could be complemented by constitutively active mutants of PI3K and Akt.	ros	45-48	thymoma viral proto-oncogene 1	Mus musculus	136-139
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	131-134	signal transducer and activator of transcription 3	Mus musculus	72-77
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	131-134	signal transducer and activator of transcription 3	Mus musculus	79-85
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	131-134	signal transducer and activator of transcription 3	Mus musculus	79-84
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	274-277	signal transducer and activator of transcription 3	Mus musculus	72-77
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	274-277	signal transducer and activator of transcription 3	Mus musculus	79-85
11799110-6	2002	Finally, we found that overexpressing a constitutively active mutant of STAT3 (STAT3C) conferred a resistance to the inhibition of Ros-induced anchorage-independent growth by LY294002, suggesting a possible overlap of functions between PI3K and STAT3 signaling in mediating Ros-induced anchorage-independent growth.	ros	274-277	signal transducer and activator of transcription 3	Mus musculus	79-84
12015896-8	2002	This inverse regulation of Mc2 and osteocalcin mRNAs was also found in ROS 17/2.8 cells and in mouse bone marrow stromal cells.	ros	71-74	bone gamma-carboxyglutamate protein	Rattus norvegicus	35-46
12575827-4	2002	FGF2 affords neuroprotection by interfering with a number of signaling pathways, including expression and gating of NMDA receptors, maintenance of Ca2+ homeostasis and regulation of ROS detoxifying enzymes.	ros	182-185	fibroblast growth factor 2	Homo sapiens	0-4
11815388-1	2002	Redox and ROS regulation of MAPK-mediated TNF-alpha biosynthesis is not well characterized.	ros	10-13	tumor necrosis factor	Homo sapiens	42-51
11815388-9	2002	LPS up-regulated ROS, an effect abrogated by 4"-hydroxy-3"-methoxy-acetophenone and NAC, which reduced TNF-alpha secretion, induced the accumulation of GSH, reduced the concentration of GSSG, and blockaded the phosphorylation/activation of MAPK(p38) pathway.	ros	17-20	tumor necrosis factor	Homo sapiens	103-112
11815388-9	2002	LPS up-regulated ROS, an effect abrogated by 4"-hydroxy-3"-methoxy-acetophenone and NAC, which reduced TNF-alpha secretion, induced the accumulation of GSH, reduced the concentration of GSSG, and blockaded the phosphorylation/activation of MAPK(p38) pathway.	ros	17-20	mitogen-activated protein kinase 14	Homo sapiens	245-248
11815388-10	2002	ROS induced MAPK(p38) phosphorylation and selective antioxidants, including the permeant GSH precursor, gamma-GCE, reduced ROS-dependent MAPK(p38) phosphorylation.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	17-20
11815388-10	2002	ROS induced MAPK(p38) phosphorylation and selective antioxidants, including the permeant GSH precursor, gamma-GCE, reduced ROS-dependent MAPK(p38) phosphorylation.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	142-145
11815388-10	2002	ROS induced MAPK(p38) phosphorylation and selective antioxidants, including the permeant GSH precursor, gamma-GCE, reduced ROS-dependent MAPK(p38) phosphorylation.	ros	123-126	mitogen-activated protein kinase 14	Homo sapiens	17-20
11815388-10	2002	ROS induced MAPK(p38) phosphorylation and selective antioxidants, including the permeant GSH precursor, gamma-GCE, reduced ROS-dependent MAPK(p38) phosphorylation.	ros	123-126	mitogen-activated protein kinase 14	Homo sapiens	142-145
11815388-11	2002	These results indicate that the MAPK pathway and MAPK-mediated regulation of TNF-alpha production is redox-dependent, GSH-mediated and requires, at least in part, a NF-kappaB/ROS-sensitive mechanism.	ros	175-178	tumor necrosis factor	Homo sapiens	77-86
11891855-5	2002	In addition, we find that reduced CpG methylation of the OC gene accompanies active transcription in ROS 17/2.8 rat osteosarcoma cells.	ros	101-104	bone gamma-carboxyglutamate protein	Rattus norvegicus	57-59
11752025-12	2002	Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) but not activator protein-1 was involved in the upregulation of ROS-induced GM-CSF production.	ros	137-140	nuclear factor kappa B subunit 1	Homo sapiens	39-60
11752025-12	2002	Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) but not activator protein-1 was involved in the upregulation of ROS-induced GM-CSF production.	ros	137-140	nuclear factor kappa B subunit 1	Homo sapiens	62-71
11772934-2	2002	To examine the effect of this on cell proliferation and differentiation, we have developed transfectant variants of a rat osteosarcoma cell line that express cDNA for 11beta-HSD1 (ROS 17/2.8beta1) or 11beta-HSD2 (ROS 17/2.8beta2).	ros	180-183	hydroxysteroid 11-beta dehydrogenase 1	Rattus norvegicus	167-178
11519039-1	2001	Current evidence has suggested the possible involvement of ROS as signaling messengers in IL-1beta- or LPS-induced gene expression.	ros	59-62	interleukin 1 beta	Homo sapiens	90-98
12112014-0	2002	Activation of bone sialoprotein gene transcription by flavonoids is mediated through an inverted CCAAT box in ROS 17/2.8 cells.	ros	110-113	integrin-binding sialoprotein	Rattus norvegicus	14-31
12112014-3	2002	The present study investigates regulation of BSP transcription in rat osteosarcoma ROS 17/2.8 cells by flavonoids: genistein (an inhibitor of protein tyrosine kinases), daidzein (an inactive compound of genistein), flavone, and flavanone.	ros	83-86	integrin-binding sialoprotein	Rattus norvegicus	45-48
12112014-4	2002	Genistein, daidzein, and flavone (50 microM) increased steady state levels of BSP mRNA about 1.7-fold at 12 h. From transient transfection assays using various sized BSP promoter-luciferase constructs, genistein increased luciferase activities within 12 h. Constructs including the promoter sequence nucleotides (nts) -116 to -43 (pLUC3) were found to enhance transcriptional activity approximately 2.6-fold in ROS 17/2.8 cells treated with genistein (50 microM).	ros	411-414	integrin-binding sialoprotein	Rattus norvegicus	78-81
11684667-7	2001	When Erk activation is inhibited, ureteric bud tips show less cell proliferation than controls and they also produce fewer laminin-rich processes penetrating the mesenchyme and fail to show the strong concentration of apical actin filaments typical of controls; apoptosis and expression of Ret and Ros, are, however, normal.	ros	298-301	mitogen-activated protein kinase 1	Mus musculus	5-8
11641265-5	2001	Treatment of HCAEC with VEGF resulted in a transient increase in ROS production at 20 min, as measured by 2,7-dichlorodihydrofluorescein oxidation.	ros	65-68	vascular endothelial growth factor A	Homo sapiens	24-28
11517178-5	2001	Phex-expressing C5.18 chondrocytes displayed the highest activity of the transfected Phex promoter constructs compared with non-Phex-expressing COS-7 cells, whereas promoter activity was intermediate in ROS 17/2.8 osteoblasts and maturation stage-dependent in MC3T3-E1 osteoblasts.	ros	203-206	phosphate regulating endopeptidase homolog, X-linked	Mus musculus	0-4
11526541-3	2001	TGF-beta1 mediates radical oxygen species (ROS) production that precedes bcl-xL down-regulation, loss of mitochondrial transmembrane potential, release of cytochrome c, and activation of caspase-3 (Herrera et al., FASEB J 2001;15:741-751).	ros	43-46	transforming growth factor, beta 1	Rattus norvegicus	0-9
11519039-3	2001	Here, we provide evidence that ROS-generating anthracycline antibiotics, including doxorubicin and aclarubicin, upregulate uPA expression in 2 human malignant cell lines, RC-K8 and H69 small-cell lung-carcinoma cells.	ros	31-34	plasminogen activator, urokinase	Homo sapiens	123-126
11519039-10	2001	These findings suggest that the anthracycline induces uPA in human malignant cells by activating gene transcription in which ROS may be involved.	ros	125-128	plasminogen activator, urokinase	Homo sapiens	54-57
11313345-6	2001	Under the same conditions, Cx43 also was isolated with anti-Cx45 antiserum from Cx45-transfected ROS cells (ROS/Cx45 cells).	ros	97-100	gap junction protein gamma 1	Homo sapiens	80-84
11485310-4	2001	Using antisera generated against the two different amino terminal sequences of type-I and type-II RUNX2, we show the expression of both isoforms in cells with the mature osteoblast phenotype (fetal rat calvarial cells, and ROS 17/2.8, SaOS-2 and U2OS osteosarcoma cell lines), but only type-I in partially differentiated osteoblast-like cells (the UMR-106 osteosarcoma cell line).	ros	223-226	RUNX family transcription factor 2	Rattus norvegicus	98-103
11524248-1	2001	We investigated the mechanism of thyroid hormone regulation of osteocalcin (OC) gene expression in osteoblast-like cells (ROS 17/2.8).	ros	122-125	bone gamma-carboxyglutamate protein	Rattus norvegicus	63-74
11524248-1	2001	We investigated the mechanism of thyroid hormone regulation of osteocalcin (OC) gene expression in osteoblast-like cells (ROS 17/2.8).	ros	122-125	bone gamma-carboxyglutamate protein	Rattus norvegicus	76-78
11524248-11	2001	In conclusion, T3 up-regulates the OC mRNA expression in ROS 17/2.8 cells in a dose-, time- and cell confluence-dependent fashion, and does so by transcriptional and post-transcriptional mechanisms.	ros	57-60	bone gamma-carboxyglutamate protein	Rattus norvegicus	35-37
11524248-12	2001	The greater T3 induction of OC expression in ROS 17/2.8 cells at low cell density is consistent with findings of thyroid hormone action on bone development.	ros	45-48	bone gamma-carboxyglutamate protein	Rattus norvegicus	28-30
11313345-6	2001	Under the same conditions, Cx43 also was isolated with anti-Cx45 antiserum from Cx45-transfected ROS cells (ROS/Cx45 cells).	ros	97-100	gap junction protein gamma 1	Homo sapiens	80-84
11313345-6	2001	Under the same conditions, Cx43 also was isolated with anti-Cx45 antiserum from Cx45-transfected ROS cells (ROS/Cx45 cells).	ros	108-111	gap junction protein gamma 1	Homo sapiens	80-84
11313345-6	2001	Under the same conditions, Cx43 also was isolated with anti-Cx45 antiserum from Cx45-transfected ROS cells (ROS/Cx45 cells).	ros	108-111	gap junction protein gamma 1	Homo sapiens	80-84
11313345-7	2001	Cx43 antiserum could also coprecipitate ZO-1 in the transfected and untransfected ROS cells.	ros	82-85	tight junction protein 1	Homo sapiens	40-44
11313345-8	2001	Double label immunofluorescence studies showed that ZO-1, Cx43, and Cx45 colocalized at appositional membranes in ROS/Cx45 cells suggesting that all three proteins are normally associated in the cells.	ros	114-117	tight junction protein 1	Homo sapiens	52-56
11313345-8	2001	Double label immunofluorescence studies showed that ZO-1, Cx43, and Cx45 colocalized at appositional membranes in ROS/Cx45 cells suggesting that all three proteins are normally associated in the cells.	ros	114-117	gap junction protein gamma 1	Homo sapiens	68-72
11083876-8	2001	Given the importance of cytotoxicity and apoptosis to the pathology of the ischemic heart, an anti-apoptotic effect of TLR2 in cardiac myocytes exposed to elevated levels of ROS may limit further cardiac dysfunction.	ros	174-177	Tlr2	Cricetulus griseus	119-123
11250917-3	2001	We also looked at the capacity of these PTH preparations to react with the PTH/PTHrP receptor and with a receptor for the carboxyl (C)-terminal portion of PTH (C-PTH receptor) in rat osteosarcoma cells, ROS 17/2.8.	ros	203-206	parathyroid hormone	Rattus norvegicus	40-43
11283267-4	2001	Gel mobility shift analyses with nuclear extracts from ROS 17/2.8 osteoblastic cells revealed that multiple Cbfa consensus sequences are functional Cbfa DNA binding sites.	ros	55-58	Y-box binding protein 1	Homo sapiens	108-112
11277270-4	2001	Only ROS 17/2.8 cells expressed measurable PMCA1 protein by Western analysis.	ros	5-8	ATPase plasma membrane Ca2+ transporting 1	Rattus norvegicus	43-48
11277270-5	2001	Immunocytochemistry indicated that PMCA1 was expressed predominantly on the plasma membrane of ROS 17/2.8 cells.	ros	95-98	ATPase plasma membrane Ca2+ transporting 1	Rattus norvegicus	35-40
12064590-2	2001	Studies demonstrated that Cx45 transfected ROS (ROS/Cx45) cells, were less permeable to low molecular weight dyes than untransfected ROS cells, that have gap junctions made of Cx43.	ros	43-46	gap junction protein gamma 1	Homo sapiens	26-30
11264896-11	2001	On the other hand, ROS scavenging enzymes, superoxide dismutase and catalase, inhibited the leakage of LDH, whereas they had no effect on the increase in the nitrite level.	ros	19-22	catalase	Homo sapiens	68-76
11267705-8	2001	CYP2E1 is known to generate ROS in vivo, the modulation of this isoform in lymphocytes from IDDM subjects, could well add to the oxidative stress associated with IDDM and the development of associated complications.	ros	28-31	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	0-6
11360927-8	2001	Thus, overall, these results show that PDTC induces apoptosis and suggest that JNK/SAPK and subsequent AP-1 activation may be involved in the apoptotic pathway in ROS 17/2.8 osteoblasts.	ros	163-166	mitogen-activated protein kinase 8	Homo sapiens	79-87
12064590-2	2001	Studies demonstrated that Cx45 transfected ROS (ROS/Cx45) cells, were less permeable to low molecular weight dyes than untransfected ROS cells, that have gap junctions made of Cx43.	ros	43-46	gap junction protein gamma 1	Homo sapiens	52-56
15256925-5	2001	These results suggest that, in some selected cases, SOD and catalase supplementation can contribute greatly to the prevention of sperm membrane lipid peroxidation by ROS and thus allow good sperm parameter recovery after freezing-thawing procedures.	ros	166-169	superoxide dismutase 1	Homo sapiens	52-55
15256925-5	2001	These results suggest that, in some selected cases, SOD and catalase supplementation can contribute greatly to the prevention of sperm membrane lipid peroxidation by ROS and thus allow good sperm parameter recovery after freezing-thawing procedures.	ros	166-169	catalase	Homo sapiens	60-68
12064590-2	2001	Studies demonstrated that Cx45 transfected ROS (ROS/Cx45) cells, were less permeable to low molecular weight dyes than untransfected ROS cells, that have gap junctions made of Cx43.	ros	48-51	gap junction protein gamma 1	Homo sapiens	26-30
12064590-2	2001	Studies demonstrated that Cx45 transfected ROS (ROS/Cx45) cells, were less permeable to low molecular weight dyes than untransfected ROS cells, that have gap junctions made of Cx43.	ros	48-51	gap junction protein gamma 1	Homo sapiens	26-30
12064590-5	2001	In order to isolate connexin interacting proteins, we isolated Cx45 from Cx45 transfected ROS cells (ROS/Cx45 cells) under mild detergent conditions.	ros	90-93	gap junction protein gamma 1	Homo sapiens	63-67
12064590-5	2001	In order to isolate connexin interacting proteins, we isolated Cx45 from Cx45 transfected ROS cells (ROS/Cx45 cells) under mild detergent conditions.	ros	90-93	gap junction protein gamma 1	Homo sapiens	73-77
12064590-5	2001	In order to isolate connexin interacting proteins, we isolated Cx45 from Cx45 transfected ROS cells (ROS/Cx45 cells) under mild detergent conditions.	ros	90-93	gap junction protein gamma 1	Homo sapiens	73-77
12064590-5	2001	In order to isolate connexin interacting proteins, we isolated Cx45 from Cx45 transfected ROS cells (ROS/Cx45 cells) under mild detergent conditions.	ros	101-104	gap junction protein gamma 1	Homo sapiens	63-67
12064590-7	2001	Immunofluorescence studies of ROS/Cx45 cells simultaneously stained with polyclonal Cx45 antibody and a monoclonal ZO-1 antibody showed that Cx45 and ZO-1 colocalized in ROS/Cx45 cells.	ros	30-33	gap junction protein gamma 1	Homo sapiens	84-88
12064590-7	2001	Immunofluorescence studies of ROS/Cx45 cells simultaneously stained with polyclonal Cx45 antibody and a monoclonal ZO-1 antibody showed that Cx45 and ZO-1 colocalized in ROS/Cx45 cells.	ros	30-33	gap junction protein gamma 1	Homo sapiens	84-88
12064590-7	2001	Immunofluorescence studies of ROS/Cx45 cells simultaneously stained with polyclonal Cx45 antibody and a monoclonal ZO-1 antibody showed that Cx45 and ZO-1 colocalized in ROS/Cx45 cells.	ros	30-33	tight junction protein 1	Homo sapiens	150-154
12064590-7	2001	Immunofluorescence studies of ROS/Cx45 cells simultaneously stained with polyclonal Cx45 antibody and a monoclonal ZO-1 antibody showed that Cx45 and ZO-1 colocalized in ROS/Cx45 cells.	ros	30-33	gap junction protein gamma 1	Homo sapiens	84-88
12064590-9	2001	These data suggests that Cx45 and ZO-1 directly interact in ROS/Cx45 cells.	ros	60-63	gap junction protein gamma 1	Homo sapiens	25-29
12064590-9	2001	These data suggests that Cx45 and ZO-1 directly interact in ROS/Cx45 cells.	ros	60-63	tight junction protein 1	Homo sapiens	34-38
12064590-9	2001	These data suggests that Cx45 and ZO-1 directly interact in ROS/Cx45 cells.	ros	60-63	gap junction protein gamma 1	Homo sapiens	64-68
11145578-7	2001	Pretreatment with PTH (10(-)(10)-10(-)(6) M) or PTHrP (10(-)(9) M) for 3-4 days resulted in a dose-dependent up-regulation of TR in ROS 17/2.8 cells.	ros	132-135	parathyroid hormone	Rattus norvegicus	18-21
11127200-0	2000	Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor beta1 and bone morphogenetic protein 2 in ROS 17/2.8 osteoblast-like cells.	ros	162-165	transforming growth factor, beta 1	Rattus norvegicus	93-125
11149894-1	2001	A critical first-line antioxidant defense on the airway epithelial surface against reactive oxygen and nitrogen species (ROS and RNS) is extracellular glutathione peroxidase (eGPx).	ros	121-124	glutathione peroxidase 3	Homo sapiens	137-173
11149894-1	2001	A critical first-line antioxidant defense on the airway epithelial surface against reactive oxygen and nitrogen species (ROS and RNS) is extracellular glutathione peroxidase (eGPx).	ros	121-124	glutathione peroxidase 3	Homo sapiens	175-179
11149894-5	2001	The eGPx mRNA in bronchial epithelial cells in vitro increased eightfold after exposure to ROS and glutathione, an essential cofactor for eGPx activity.	ros	91-94	glutathione peroxidase 3	Homo sapiens	4-8
11149894-5	2001	The eGPx mRNA in bronchial epithelial cells in vitro increased eightfold after exposure to ROS and glutathione, an essential cofactor for eGPx activity.	ros	91-94	glutathione peroxidase 3	Homo sapiens	138-142
11149894-9	2001	Fusion genes of deletion fragments of the eGPx gene 5" flanking region driving a reporter gene conclusively identified the ROS-responsive region, which contained the consensus DNA binding site for the redox-regulated transcription factor, activator protein 1.	ros	123-126	glutathione peroxidase 3	Homo sapiens	42-46
11161470-6	2001	Following MPP+-treatment, myr-EGFP-Akt1-transfected cells exhibited an unaltered mitochondrial membrane potential and lower ROS levels than control cells.	ros	124-127	AKT serine/threonine kinase 1	Rattus norvegicus	35-39
11173974-2	2001	Although not yet well understood, ethanol may enhance ROS production in brain through a number of pathways including increased generation of hydroxyethyl radicals, induction of CYP2E1, alteration of the cytokine signaling pathways for induction of iNOS and sPLA(2), and production of prostanoids through the PLA(2)/COX pathways.	ros	54-57	phospholipase A2 group X	Homo sapiens	257-263
11173974-2	2001	Although not yet well understood, ethanol may enhance ROS production in brain through a number of pathways including increased generation of hydroxyethyl radicals, induction of CYP2E1, alteration of the cytokine signaling pathways for induction of iNOS and sPLA(2), and production of prostanoids through the PLA(2)/COX pathways.	ros	54-57	phospholipase A2 group IB	Homo sapiens	258-263
11255228-3	2001	Analysis of mRNA from ROS 25/1, UMR 106 and ROS 17/2.8 cells revealed transcripts for both 11 beta-HSD type 1 (11 beta-HSD1) and type 2 (11 beta-HSD2) in all three cell lines.	ros	22-25	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	94-123
11255228-3	2001	Analysis of mRNA from ROS 25/1, UMR 106 and ROS 17/2.8 cells revealed transcripts for both 11 beta-HSD type 1 (11 beta-HSD1) and type 2 (11 beta-HSD2) in all three cell lines.	ros	44-47	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 5	Rattus norvegicus	94-123
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	transforming growth factor, beta 1	Rattus norvegicus	145-154
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	transforming growth factor, beta 1	Rattus norvegicus	230-239
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	parathyroid hormone	Rattus norvegicus	268-287
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	parathyroid hormone	Rattus norvegicus	289-292
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	parathyroid hormone	Rattus norvegicus	294-297
11116210-2	2000	ROS 17/2.8 cells, a rat osteoblast-like osteosarcoma cell line, express the PTH/PTHrP receptor and provide a good model for examining the transcriptional regulation of its gene.	ros	0-3	parathyroid hormone	Rattus norvegicus	76-79
11108147-10	2000	NF-kappaB activation depends upon the activity of DAG-sensitive PKC isoforms and ROS signaling pathway.	ros	81-84	nuclear factor kappa B subunit 1	Homo sapiens	0-9
10997555-0	2000	Rhodostomin inhibits the transforming growth factor-beta1-enhanced adhesion activity of ROS 17/2.8 osteosarcoma cells.	ros	88-91	transforming growth factor, beta 1	Rattus norvegicus	25-57
10980416-2	2000	Parathyroid hormone (PTH), which regulates serum calcium through its actions on bone cells, increases the expression of BSP in the rat osteosarcoma cell line (ROS 17/2.8).	ros	159-162	parathyroid hormone	Rattus norvegicus	0-19
10980416-2	2000	Parathyroid hormone (PTH), which regulates serum calcium through its actions on bone cells, increases the expression of BSP in the rat osteosarcoma cell line (ROS 17/2.8).	ros	159-162	parathyroid hormone	Rattus norvegicus	21-24
10980416-2	2000	Parathyroid hormone (PTH), which regulates serum calcium through its actions on bone cells, increases the expression of BSP in the rat osteosarcoma cell line (ROS 17/2.8).	ros	159-162	integrin-binding sialoprotein	Rattus norvegicus	120-123
10920219-4	2000	On the other hand, ROS cells with high expression levels of osteoblast markers and no EGF-R, after being transfected with human EGF-R cDNA (EROS cells), expressed numerous EGF-binding sites as well as EGF-R mRNA and protein; in the process, they ceased to express osteoblast markers, indicating their dedifferentiation into osteoprogenitor cells.	ros	19-22	epidermal growth factor receptor	Homo sapiens	128-133
10893342-5	2000	Osteoblastic ROS 17/2.8 cells transfected with a dose of NF-kappaB comparable to that stimulated by TNF-alpha decreased 1,25(OH)(2)D(3)-stimulated transcription.	ros	13-16	tumor necrosis factor	Rattus norvegicus	100-109
10980416-8	2000	Binding of a nuclear protein, recognized by anti-Pit-1 antibodies, to a radiolabelled Pit-1-BSP probe was decreased in nuclear extracts prepared from PTH, forskolin and isoproterenol-stimulated ROS 17/2.8 cells.	ros	194-197	POU class 1 homeobox 1	Rattus norvegicus	49-54
10980416-8	2000	Binding of a nuclear protein, recognized by anti-Pit-1 antibodies, to a radiolabelled Pit-1-BSP probe was decreased in nuclear extracts prepared from PTH, forskolin and isoproterenol-stimulated ROS 17/2.8 cells.	ros	194-197	POU class 1 homeobox 1	Rattus norvegicus	86-91
10980416-8	2000	Binding of a nuclear protein, recognized by anti-Pit-1 antibodies, to a radiolabelled Pit-1-BSP probe was decreased in nuclear extracts prepared from PTH, forskolin and isoproterenol-stimulated ROS 17/2.8 cells.	ros	194-197	integrin-binding sialoprotein	Rattus norvegicus	92-95
10980416-8	2000	Binding of a nuclear protein, recognized by anti-Pit-1 antibodies, to a radiolabelled Pit-1-BSP probe was decreased in nuclear extracts prepared from PTH, forskolin and isoproterenol-stimulated ROS 17/2.8 cells.	ros	194-197	parathyroid hormone	Rattus norvegicus	150-153
10980416-9	2000	Moreover, co-transfection of ROS cells with a double-stranded Pit-1 oligonucleotide also increased luciferase activity.	ros	29-32	POU class 1 homeobox 1	Rattus norvegicus	62-67
10916099-9	2000	In osteoblast-like cells, ROS 17.2, 1-84 PTH (10-8 mol/L) increased cAMP from 18.1 +/- 1.25 to 738 +/- 4.13 mmol/well.	ros	26-29	parathyroid hormone	Homo sapiens	41-44
10997555-3	2000	The results showed that incubation with various concentration of TGF-beta1 (1-15 ng/ml) significantly increased the adhesion activity (1.4 to 2.5 folds) of ROS 17/2.8 to fibronectin and type I collagen (p&lt;0.01), whereas the adhesion activity to laminin and type IV collagen was slightly elevated (1.1 to 1.5 folds).	ros	156-159	transforming growth factor, beta 1	Rattus norvegicus	65-74
10997555-4	2000	The peak effect of TGF-beta1 on the cell adhesion occurred after pretreatment of ROS 17/2.8 with TGF-beta1 for 6 hours.	ros	81-84	transforming growth factor beta 1	Homo sapiens	19-28
10997555-4	2000	The peak effect of TGF-beta1 on the cell adhesion occurred after pretreatment of ROS 17/2.8 with TGF-beta1 for 6 hours.	ros	81-84	transforming growth factor beta 1	Homo sapiens	97-106
10997555-6	2000	This study demonstrated that the up-regulated cell adhesion activity of ROS 17/2.8 cells by the TGF-beta1 can be inhibited by the rhodostomin.	ros	72-75	transforming growth factor, beta 1	Rattus norvegicus	96-105
10855687-0	2000	Regulation of PTH/PTH-related protein receptor expression by endogenous PTH-related protein in the rat osteosarcoma cell line ROS 17/2.8.	ros	126-129	parathyroid hormone	Rattus norvegicus	14-17
10804028-1	2000	Human parathyroid hormone (1-28)NH2 [hPTH(1-28)NH2] is the smallest of the PTH fragments that can fully stimulate adenylyl cyclase in ROS 17/2 rat osteoblast-like osteosarcoma cells.	ros	134-137	parathyroid hormone	Rattus norvegicus	38-41
10855687-0	2000	Regulation of PTH/PTH-related protein receptor expression by endogenous PTH-related protein in the rat osteosarcoma cell line ROS 17/2.8.	ros	126-129	parathyroid hormone	Rattus norvegicus	18-21
10855687-0	2000	Regulation of PTH/PTH-related protein receptor expression by endogenous PTH-related protein in the rat osteosarcoma cell line ROS 17/2.8.	ros	126-129	parathyroid hormone	Rattus norvegicus	18-21
10855687-5	2000	Using antisense-transfected ROS cells, PTH/PTHrP receptor mRNA expression and 125I-[Tyr36] PTHrP (1-36) binding were downregulated by treatment for 24 h with exogenous PTHrP (1-36), forskolin, or dibutyryl cAMP.	ros	28-31	parathyroid hormone	Rattus norvegicus	39-42
10673374-2	2000	VIP(170) is expressed in osteoblast-like ROS 17/2.8 cells and, to a lesser extent, in COS-7 and HeLa cells.	ros	41-44	vasoactive intestinal peptide	Rattus norvegicus	0-3
10600523-5	1999	The signal transduction pathway of PTH-induced ECAR in ROS 17/2 cells was investigated to compare with previous results in SaOS-2 cells.	ros	55-58	parathyroid hormone	Homo sapiens	35-38
10571055-4	1999	Both regions are critical for the activation of ROS-GCI by GCAP-1.	ros	48-51	guanylate cyclase activator 1A	Homo sapiens	59-65
10593410-3	1999	We utilized ROS rendered communication deficient either by stable transfection with antisense cDNA to connexin 43 (Cx43), the predominant gap junction protein in bone (RCx16 cells), or by overexpression of Cx45, a gap junction protein not normally expressed in ROS (ROS/Cx45 cells).	ros	12-15	gap junction protein, alpha 1	Rattus norvegicus	102-113
10593410-4	1999	Both RCx16 and ROS/Cx45 cells displayed reduced dye coupling and Cx43 protein expression relative to ROS, control transfectants, and ROS/Cx45tr, ROS cells expressing carboxylterminal truncated Cx45.	ros	15-18	gap junction protein, alpha 1	Rattus norvegicus	65-69
10606245-6	1999	Overexpression of CDP/cut in ROS 17/2.8 osteosarcoma cells results in repression of OC promoter activity; this repression is abrogated by mutating OC box I. Gel shift immunoassays show that CDP/cut forms a proliferation-specific protein/DNA complex in conjunction with cyclin A and p107, a member of the retinoblastoma protein family of tumor suppressors.	ros	29-32	bone gamma-carboxyglutamate protein	Rattus norvegicus	84-86
10531389-5	1999	In conclusion, DNR-triggered apoptosis implicates a ceramide-mediated, ROS-dependent JNK and activated protein-1 activation.	ros	71-74	mitogen-activated protein kinase 8	Homo sapiens	85-88
10321921-5	1999	Further studies have shown that IL-6, c-fos, and Bcl-2 are all elevated in Paget"s disease--all of these factors can be activated by virally induced ROS.	ros	149-152	interleukin 6	Homo sapiens	32-36
10592533-5	1999	In addition, sWBC as well as basal and maximal fMLP-mediated WBC-ROS production were also carried out by conventional immunocytochemistry staining and chemiluminescence analysis respectively.	ros	65-68	formyl peptide receptor 1	Homo sapiens	47-51
10592533-10	1999	Moreover, treated patients of each group had amounts of generated basal and fMLP-stimulated ROS signals significantly reduced, with values ensued within a fertile control range at T2, in 80, 62.5 and 42.8% out of the P, PV and PVE groups respectively.	ros	92-95	formyl peptide receptor 1	Homo sapiens	76-80
10465284-5	1999	Transient gene expression assays of wild-type and mutant osteocalcin-CAT fusion genes into ROS 17/2.8 cells demonstrate that mutagenesis of either of these CCTCCT motifs in isolation results in a 1.6-fold increase in CAT activity relative to the parent fusion gene.	ros	91-94	bone gamma-carboxyglutamate protein	Rattus norvegicus	57-68
10424766-2	1999	Treatment of rat osteosarcoma (ROS)17/2.8, an osteoblast-like cell line, with 1alpha,25(OH)2D3 results in a ligand-dependent increase in transcription of the bone-specific osteocalcin gene.	ros	31-34	bone gamma-carboxyglutamate protein	Rattus norvegicus	172-183
10358067-10	1999	In addition, recombinant human CTGF-L inhibits osteocalcin production in rat osteoblast-like Ros 17/2.8 cells.	ros	93-96	bone gamma-carboxyglutamate protein	Homo sapiens	47-58
10329388-3	1999	This study has demonstrated specific PTH/PTHrP receptor expression from the U3 promoter in the osteoblastic osteosarcoma ROS 17/2.8 cell line, which expresses the endogenous PTH/PTHrP receptor, compared to rat 2 fibroblasts which do not express the endogenous PTH/PTHrP receptor gene.	ros	121-124	parathyroid hormone	Rattus norvegicus	37-40
10329388-3	1999	This study has demonstrated specific PTH/PTHrP receptor expression from the U3 promoter in the osteoblastic osteosarcoma ROS 17/2.8 cell line, which expresses the endogenous PTH/PTHrP receptor, compared to rat 2 fibroblasts which do not express the endogenous PTH/PTHrP receptor gene.	ros	121-124	parathyroid hormone	Rattus norvegicus	41-44
10329388-3	1999	This study has demonstrated specific PTH/PTHrP receptor expression from the U3 promoter in the osteoblastic osteosarcoma ROS 17/2.8 cell line, which expresses the endogenous PTH/PTHrP receptor, compared to rat 2 fibroblasts which do not express the endogenous PTH/PTHrP receptor gene.	ros	121-124	parathyroid hormone	Rattus norvegicus	41-44
10329388-6	1999	These data suggest that cell-specific expression in ROS 17/2.8 involves cell-specific elements within the PTH/PTHrP receptor promoter.	ros	52-55	parathyroid hormone	Rattus norvegicus	106-109
10614720-7	1999	RESULTS: During normal liver regeneration, TNF induces potentially dangerous responses, such as increased mitochondrial ROS production, but also promotes the activation of several factors, including NF kappa B, Jun N-terminal Kinase (JNK), and various mitochondrial membrane proteins, which are likely to permit hepatocytes to survive apoptotic and oxidant stress.	ros	120-123	tumor necrosis factor	Rattus norvegicus	43-46
10430646-8	1999	In vitro, ROS 17/2.8 cells expressed detectable levels of c-fos, c-jun, c-myc, OC, OP, ALP, COL1A1, and PTHR but not MMP-9.	ros	10-13	bone gamma-carboxyglutamate protein	Rattus norvegicus	79-81
10430646-8	1999	In vitro, ROS 17/2.8 cells expressed detectable levels of c-fos, c-jun, c-myc, OC, OP, ALP, COL1A1, and PTHR but not MMP-9.	ros	10-13	collagen type I alpha 1 chain	Rattus norvegicus	92-98
10430648-2	1999	This was based on the osteogenic action in ovariectomized (OVX) rats of hPTH-(1-31)NH(2), which can stimulate adenylyl cyclase but not PLC in ROS 17/2 rat osteosarcoma cells, and the osteogenic impotence of fragments such as 1-desamino-hPTH-(1-34) and hPTH-(8-84) which strongly stimulate PLC but not adenylyl cyclase.	ros	142-145	parathyroid hormone	Homo sapiens	72-76
10321921-5	1999	Further studies have shown that IL-6, c-fos, and Bcl-2 are all elevated in Paget"s disease--all of these factors can be activated by virally induced ROS.	ros	149-152	BCL2 apoptosis regulator	Homo sapiens	49-54
10352371-9	1999	The increase of ROS production following stimulation with FMLP, C5a or PMA was 60.4 +/- 21.6, 86.0 +/- 23.3, and 63.3 +/- 15.9% (SEM), respectively.	ros	16-19	formyl peptide receptor 1	Homo sapiens	58-62
10352371-9	1999	The increase of ROS production following stimulation with FMLP, C5a or PMA was 60.4 +/- 21.6, 86.0 +/- 23.3, and 63.3 +/- 15.9% (SEM), respectively.	ros	16-19	complement C5a receptor 1	Homo sapiens	64-67
10352371-4	1999	MATERIAL AND METHODS: We therefore investigated the production of reactive oxygen radical species (ROS) measured by lucigenin-dependent chemiluminescence after stimulation with N-formylpeptide (FMLP, 10(-6) and 10(-7) M), C5a complement (10(-7) and 10(-8) M) or phorbolester (PMA, 10(-7) and 10(-8) M) in isolated PMN of 8 volunteers undergoding a 60-min hyperthermia treatment with the WBIAI.	ros	99-102	formyl peptide receptor 1	Homo sapiens	194-198
9914323-4	1999	In marked contrast, incubation of intact ROS 17/2.8 cells with OST-766 for at least 48 hours resulted in an increase in basal ACA as well as in response to PTH, guanine nucleotides and forskolin.	ros	41-44	parathyroid hormone	Rattus norvegicus	156-159
10353689-1	1999	Human parathyroid hormone, hPTH-(1-34), stimulates adenylyl cyclase and phosphatidylinositol-bisphosphate-specific phospholipase-C (PIP2-PLC), as indicated by increased membrane-associated protein kinase C (PKC) activity in ROS 17/2 rat osteosarcoma cells.	ros	224-227	parathyroid hormone	Homo sapiens	27-31
10353689-3	1999	Even [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, a 6-fold stronger adenylyl cyclase stimulator than hPTH-(1-34), cannot stimulate PKC activity in ROS cells.	ros	145-148	parathyroid hormone	Homo sapiens	32-36
10076048-5	1999	Protective effects of cycloheximide, which enhances the expression of Bcl-2 protein, may further confirm our hypothesis that the megamitochondria formation is a cellular response to an increased ROS generation and raise a possibility that antiapoptotic action of the drug is exerted via the protection of the mitochondria functions.	ros	195-198	BCL2, apoptosis regulator	Rattus norvegicus	70-75
10609876-5	1999	From the cytotoxic properties and susceptibility to scavenging of TNF-induced ROS as compared to pro-oxidant-induced ROS we conclude that TNF-mediated ROS generation and their lethal action are confined to the inner mitochondrial membrane.	ros	78-81	tumor necrosis factor	Mus musculus	66-69
10609876-5	1999	From the cytotoxic properties and susceptibility to scavenging of TNF-induced ROS as compared to pro-oxidant-induced ROS we conclude that TNF-mediated ROS generation and their lethal action are confined to the inner mitochondrial membrane.	ros	78-81	tumor necrosis factor	Mus musculus	138-141
10609876-2	1999	We previously reported an increased generation of ROS in TNF-treated L929 fibrosarcoma cells prior to cell death.	ros	50-53	tumor necrosis factor	Mus musculus	57-60
10609876-5	1999	From the cytotoxic properties and susceptibility to scavenging of TNF-induced ROS as compared to pro-oxidant-induced ROS we conclude that TNF-mediated ROS generation and their lethal action are confined to the inner mitochondrial membrane.	ros	117-120	tumor necrosis factor	Mus musculus	138-141
10609876-5	1999	From the cytotoxic properties and susceptibility to scavenging of TNF-induced ROS as compared to pro-oxidant-induced ROS we conclude that TNF-mediated ROS generation and their lethal action are confined to the inner mitochondrial membrane.	ros	117-120	tumor necrosis factor	Mus musculus	138-141
10609876-6	1999	Oxidative substrates, electron-transport inhibitors, glutathione and thiol-reactive agents but also caspase inhibitors modulate TNF-induced ROS production and imply the existence of a negative regulator of ROS production.	ros	140-143	tumor necrosis factor	Mus musculus	128-131
10609876-6	1999	Oxidative substrates, electron-transport inhibitors, glutathione and thiol-reactive agents but also caspase inhibitors modulate TNF-induced ROS production and imply the existence of a negative regulator of ROS production.	ros	206-209	tumor necrosis factor	Mus musculus	128-131
10609876-7	1999	Inactivation of this regulator by a TNF-induced reduction of NAD(P)H levels and/or formation of intraprotein disulfides would be responsible for ROS generation.	ros	145-148	tumor necrosis factor	Mus musculus	36-39
9812998-8	1998	Furthermore, Smad2 overexpression also suppressed transcriptional activity of the 1-kilobase pair osteocalcin gene promoter, which was linked to chloramphenicol acetyltransferase reporter gene in both ROS and PRC cells.	ros	201-204	bone gamma-carboxyglutamate protein	Rattus norvegicus	98-109
10507060-3	1999	Especially important are markers for protein oxidation, lipid peroxidation, and ROS generation by A beta.	ros	80-83	amyloid beta precursor protein	Homo sapiens	98-104
9572838-1	1998	Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated after PTH treatment.	ros	30-33	parathyroid hormone	Rattus norvegicus	7-10
9797478-6	1998	As determined by immunoblotting, the level of connexin 43 protein was increased in both ROS/Cx45tr and ROS/Cx45 cell lines compared with ROS cells, while the level in RCx16 cells was reduced.	ros	88-91	gap junction protein, alpha 1	Rattus norvegicus	46-57
9797478-6	1998	As determined by immunoblotting, the level of connexin 43 protein was increased in both ROS/Cx45tr and ROS/Cx45 cell lines compared with ROS cells, while the level in RCx16 cells was reduced.	ros	103-106	gap junction protein, alpha 1	Rattus norvegicus	46-57
9788898-5	1998	ROS/RNS appear to play a variety of roles that lead to changes in expression of genes such as interleukin-6 and intercellular adhesion molecule 1.	ros	0-3	interleukin 6	Homo sapiens	94-107
9693379-5	1998	Transfection of Cx45 in cells that express primarily Cx43 (ROS 17/2.8 and MC3T3-E1) decreased both dye transfer and expression of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix formation and calcification.	ros	59-62	gap junction protein, alpha 1	Rattus norvegicus	53-57
9693379-5	1998	Transfection of Cx45 in cells that express primarily Cx43 (ROS 17/2.8 and MC3T3-E1) decreased both dye transfer and expression of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix formation and calcification.	ros	59-62	integrin-binding sialoprotein	Rattus norvegicus	170-173
9721333-3	1998	Reactive O2 species (ROS) can also regulate force generation by vascular smooth muscle through mechanisms including the stimulation of production of vasoactive prostaglandins, the stimulation of sGC by catalase-mediated metabolism of H2O2 and inhibition of sGC activation by superoxide, the activation of protein kinase C, and the modulation of mediator release from the endothelium.	ros	21-24	sarcoglycan beta	Homo sapiens	195-198
9721333-3	1998	Reactive O2 species (ROS) can also regulate force generation by vascular smooth muscle through mechanisms including the stimulation of production of vasoactive prostaglandins, the stimulation of sGC by catalase-mediated metabolism of H2O2 and inhibition of sGC activation by superoxide, the activation of protein kinase C, and the modulation of mediator release from the endothelium.	ros	21-24	sarcoglycan beta	Homo sapiens	257-260
9799828-2	1998	A lactam derivative of hPTH-(1-31)-NH2, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, is a much more effective stimulator of adenylyl cyclase in ROS 17/2 rat osteoblast-like cells and a significantly more effective stimulator of femoral trabecular growth in OVX rats than hPTH-(1-31)NH2.	ros	142-145	parathyroid hormone	Homo sapiens	23-27
9799828-2	1998	A lactam derivative of hPTH-(1-31)-NH2, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, is a much more effective stimulator of adenylyl cyclase in ROS 17/2 rat osteoblast-like cells and a significantly more effective stimulator of femoral trabecular growth in OVX rats than hPTH-(1-31)NH2.	ros	142-145	parathyroid hormone	Homo sapiens	67-71
9799828-2	1998	A lactam derivative of hPTH-(1-31)-NH2, [Leu27]-cyclo(Glu22-Lys26)-hPTH-(1-31)NH2, is a much more effective stimulator of adenylyl cyclase in ROS 17/2 rat osteoblast-like cells and a significantly more effective stimulator of femoral trabecular growth in OVX rats than hPTH-(1-31)NH2.	ros	142-145	parathyroid hormone	Homo sapiens	67-71
9754575-7	1998	The CD4-/- block in ROS and TNC formation was rescued by the introduction of a human CD4 transgene.	ros	20-23	CD4 molecule	Homo sapiens	4-7
9754575-7	1998	The CD4-/- block in ROS and TNC formation was rescued by the introduction of a human CD4 transgene.	ros	20-23	CD4 molecule	Homo sapiens	85-88
9626627-5	1998	Al also had strong inhibitory actions on PTH-dependent cAMP production by ROS cells over the concentration range tested (0.5-50 nM).	ros	74-77	parathyroid hormone	Rattus norvegicus	41-44
9572838-3	1998	The data show that the PTH/PTHrP receptor is rapidly phosphorylated in ROS 17/2.8 cells with a maximum occurring at 20 min.	ros	71-74	parathyroid hormone	Rattus norvegicus	23-26
9572838-4	1998	The phosphorylation was dose-dependent; it occurred with PTH concentrations that are known to downregulate the PTH/PTHrP receptor in ROS 17/2.8 cells.	ros	133-136	parathyroid hormone	Rattus norvegicus	57-60
9572838-4	1998	The phosphorylation was dose-dependent; it occurred with PTH concentrations that are known to downregulate the PTH/PTHrP receptor in ROS 17/2.8 cells.	ros	133-136	parathyroid hormone	Rattus norvegicus	111-114
9572838-6	1998	PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA).	ros	38-41	parathyroid hormone	Rattus norvegicus	0-3
9572838-1	1998	Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated after PTH treatment.	ros	30-33	parathyroid hormone	Rattus norvegicus	11-14
9571173-5	1998	Thus, GCAP1 and GCAP2 act through different ROS-GCs and through two different cyclase domains.	ros	44-47	guanylate cyclase activator 1A	Homo sapiens	6-11
9610750-5	1998	The nucleotide sequence of the PTH/PTHrP receptor PCR product of hemopoietic blast cells was found to be 95.4% identical to that of PTH/PTHrP receptor cDNA of rat osteoblastic ROS cells.	ros	176-179	parathyroid hormone-like peptide	Mus musculus	35-40
9610750-5	1998	The nucleotide sequence of the PTH/PTHrP receptor PCR product of hemopoietic blast cells was found to be 95.4% identical to that of PTH/PTHrP receptor cDNA of rat osteoblastic ROS cells.	ros	176-179	parathyroid hormone-like peptide	Mus musculus	136-141
9613602-5	1998	CD-GCAP is a Ca2+-binding protein and is a specific activator of one of the two members of the ROS-GC subfamily of membrane guanylate cyclases, ROS-GC1.	ros	95-98	guanylate cyclase activator 1A	Homo sapiens	3-7
9613602-8	1998	The findings demonstrate the existence of a novel signal transduction mechanism--the linkage of the alpha(2D/A)-AR signaling system with ROS-GC1 transduction system, occurring through intracellular Ca2+ via CD-GCAP.	ros	137-140	guanylate cyclase activator 1A	Homo sapiens	210-214
9550631-1	1998	Previous studies have shown that dexamethasone enhanced the expression of parathyroid-hormone/parathyroid-hormone-related peptide (PTH/ PTHrP) receptor mRNA in ROS 17/2.8 osteosarcoma cells.	ros	160-163	parathyroid hormone	Rattus norvegicus	131-134
9556130-0	1998	Parathyroid hormone regulates the expression of the nuclear mitotic apparatus protein in the osteoblast-like cells, ROS 17/2.8.	ros	116-119	parathyroid hormone	Rattus norvegicus	0-19
9546582-5	1998	Mainly ERK2 was rapidly activated (within 10 min) by bFGF, IGF-I and PDGF-BB in normal HOB, HBMS and human osteosarcoma cells, whereas both ERK1 and ERK2 were activated by growth factors in rat osteoblast-like cell lines, ROS 17/2.8 and UMR-106.	ros	222-225	mitogen-activated protein kinase 1	Homo sapiens	7-11
9546582-5	1998	Mainly ERK2 was rapidly activated (within 10 min) by bFGF, IGF-I and PDGF-BB in normal HOB, HBMS and human osteosarcoma cells, whereas both ERK1 and ERK2 were activated by growth factors in rat osteoblast-like cell lines, ROS 17/2.8 and UMR-106.	ros	222-225	mitogen-activated protein kinase 3	Homo sapiens	140-144
9546582-5	1998	Mainly ERK2 was rapidly activated (within 10 min) by bFGF, IGF-I and PDGF-BB in normal HOB, HBMS and human osteosarcoma cells, whereas both ERK1 and ERK2 were activated by growth factors in rat osteoblast-like cell lines, ROS 17/2.8 and UMR-106.	ros	222-225	mitogen-activated protein kinase 1	Homo sapiens	149-153
9495514-8	1998	However, phosphorylated forms of Cx43 protein were more abundant in stretched ROS 17/2.8 than in controls.	ros	78-81	gap junction protein, alpha 1	Rattus norvegicus	33-37
9546582-5	1998	Mainly ERK2 was rapidly activated (within 10 min) by bFGF, IGF-I and PDGF-BB in normal HOB, HBMS and human osteosarcoma cells, whereas both ERK1 and ERK2 were activated by growth factors in rat osteoblast-like cell lines, ROS 17/2.8 and UMR-106.	ros	222-225	fibroblast growth factor 2	Homo sapiens	53-57
9334351-6	1997	ROS 17/2.8 cells, which express the gap junction protein connexin43 (Cx43), are well dye coupled, and lack P2U receptors, transmitted slow gap junction-dependent calcium waves that did not require release of intracellular calcium stores.	ros	0-3	gap junction protein, alpha 1	Rattus norvegicus	57-67
9793175-2	1998	It has been recently shown that the osteocalcin gene promoter binds specifically two proteins, NMP-1 and NMP-2 (nuclear matrix proteins 1 and 2), from cell line ROS 17/2.8 (Bidwell et al., 1993).	ros	161-164	bone gamma-carboxyglutamate protein	Homo sapiens	36-47
9334351-6	1997	ROS 17/2.8 cells, which express the gap junction protein connexin43 (Cx43), are well dye coupled, and lack P2U receptors, transmitted slow gap junction-dependent calcium waves that did not require release of intracellular calcium stores.	ros	0-3	gap junction protein, alpha 1	Rattus norvegicus	69-73
9400742-7	1997	These macrophages also release large amounts of tumor necrosis factor alpha (TNF-alpha), a cytokine that can generate responses within the airway epithelium dependent upon intracellular generation of ROS/RNS.	ros	200-203	tumor necrosis factor	Homo sapiens	48-75
9299466-4	1997	The human ERK1 moved faster on SDS-polyacrylamide gel compared to rat and mouse, revealing differences in the apparent molecular weight of FRK1 in normal human osteoblastic and bone marrow osteoprogenitor cells, human (TE-85) and rat (ROS 17/2.8 and UMR-106) osteosarcoma, and mouse (MC3T3E1) osteoblastic cells.	ros	235-238	mitogen-activated protein kinase 3	Homo sapiens	10-14
9400742-7	1997	These macrophages also release large amounts of tumor necrosis factor alpha (TNF-alpha), a cytokine that can generate responses within the airway epithelium dependent upon intracellular generation of ROS/RNS.	ros	200-203	tumor necrosis factor	Homo sapiens	77-86
9178750-7	1997	This effect is cell-specific since ERR-1 activates transcription in the rat osteosarcoma cell line ROS 17.2/8 as well as in HeLa, NB-E, and FREJ4 cells but not in COS1 and HepG2 cells.	ros	99-102	estrogen related receptor alpha	Homo sapiens	35-40
9213216-6	1997	However, unlike the normal diploid cells, the diff.ECx-i activity of proliferating ROS 17/2.8 cells is recovered by cyclin E immunoprecipitation.	ros	83-86	cyclin E1	Rattus norvegicus	116-124
9178100-3	1997	To determine the molecular pathways of TGF-beta 1 regulation of bone proteins, we have analyzed the effects of the TGF-beta 1 on the expression of the BSP in the rat osteosarcoma cell line (ROS 17/2.8).	ros	190-193	integrin-binding sialoprotein	Rattus norvegicus	151-154
9306258-3	1997	Primary osteoblast and ROS 17/2.8 cells released NO upon stimulation of interleukin-1 beta, tumour necrosis factor-alpha, and interferon-gamma.	ros	23-26	interleukin 1 beta	Rattus norvegicus	72-120
9182255-6	1997	RESULTS: After therapy all patients showed a marked increase in ROS (378 +/- 35 U Carr) compared to values measured before therapy (269 +/- 62 U Carr, p &lt; 0.0001).	ros	64-67	arrestin 3	Homo sapiens	82-86
9100025-9	1997	These findings suggest that the N-terminal region is important in tethering of GCAP1 to the ROS membranes.	ros	92-95	guanylate cyclase activator 1A	Homo sapiens	79-84
8952696-8	1996	In RC cells and the rat osteosarcoma cell line ROS 17/2.8, galectin 3 mRNA expression increased with time in culture, in contrast to its behavior in fetal rat skin fibroblasts (RSF) in which its expression decreased with time in culture.	ros	47-50	galectin 3	Rattus norvegicus	59-69
8913889-3	1996	Chronic exposure to rat PTH (1-34) [10 nM] attenuated the expression of 200, 190, and 160 kD proteins in the nuclear matrix-intermediate filament subfraction of the rat osteosarcoma cells, ROS 17/2.8 [Bidwell et al.	ros	189-192	parathyroid hormone	Rattus norvegicus	24-27
8952696-12	1996	Immunolabeling with an antibody against rat galectin 3 to identify galectin 3 protein showed that cells labelled within both the ROS 17/2.8 and RC populations but with marked intercellular heterogeneity of intensity.	ros	129-132	galectin 3	Rattus norvegicus	67-77
9015759-8	1997	Expression of PROM-1 in the ROS 17/2.8 osteosarcoma cell line was several fold greater than in normal diploid cells and was not downregulated when ROS 17/2.8 cells reached confluency.	ros	28-31	prominin 1	Rattus norvegicus	14-20
9015759-8	1997	Expression of PROM-1 in the ROS 17/2.8 osteosarcoma cell line was several fold greater than in normal diploid cells and was not downregulated when ROS 17/2.8 cells reached confluency.	ros	147-150	prominin 1	Rattus norvegicus	14-20
8913881-7	1996	ROS 17/2.8 cells responded to 1,25-(OH)2-BE but not the natural ligand with a significant increase in osteocalcin secretion after 72, 96, 120, and 144 hr of treatment.	ros	0-3	bone gamma-carboxyglutamate protein	Rattus norvegicus	102-113
8952696-12	1996	Immunolabeling with an antibody against rat galectin 3 to identify galectin 3 protein showed that cells labelled within both the ROS 17/2.8 and RC populations but with marked intercellular heterogeneity of intensity.	ros	129-132	galectin 3	Rattus norvegicus	44-54
8806719-2	1996	Here we show that osteocalcin mRNA regulation by 1,25(OH)2D3 in clonal osteoblast cells (ROS 17/2.8), besides occurring at a transcriptional level, is also regulated by a posttranscriptional mechanism.	ros	89-92	bone gamma-carboxyglutamate protein	Rattus norvegicus	18-29
8718894-3	1996	We report the identification of a sequence in the first intron of the rat osteocalcin gene which suppresses the expression of osteocalcin-CAT fusion genes approximately 10-fold in ROS 17/2.8 and UMR 106 osteosarcoma cells.	ros	180-183	bone gamma-carboxyglutamate protein	Rattus norvegicus	74-85
8718894-3	1996	We report the identification of a sequence in the first intron of the rat osteocalcin gene which suppresses the expression of osteocalcin-CAT fusion genes approximately 10-fold in ROS 17/2.8 and UMR 106 osteosarcoma cells.	ros	180-183	bone gamma-carboxyglutamate protein	Rattus norvegicus	126-137
8761475-2	1996	Our studies, using the osteoblastic cell line ROS 17/2.8, have revealed that rat BSP gene expression is suppressed by 1,25-dihydroxyvitamin D3[1,25(OH)2D3], which is a powerful regulator of bone formation and resorption.	ros	46-49	integrin-binding sialoprotein	Rattus norvegicus	81-84
8781053-7	1996	Furthermore, the intact rat osteocalcin was stable over 8 hours at 25 degrees C. Intact rat osteocalcin levels extracellularly secreted from ROS 17/2.8 cells were measured by this method, showing time- and dose-dependent significant increases when administered 1,25(OH)2D3.	ros	141-144	bone gamma-carboxyglutamate protein	Rattus norvegicus	28-39
8781053-7	1996	Furthermore, the intact rat osteocalcin was stable over 8 hours at 25 degrees C. Intact rat osteocalcin levels extracellularly secreted from ROS 17/2.8 cells were measured by this method, showing time- and dose-dependent significant increases when administered 1,25(OH)2D3.	ros	141-144	bone gamma-carboxyglutamate protein	Rattus norvegicus	92-103
8980892-5	1996	Although cAMP production induced by exogenous PTH was suppressed in ROS/PLP/6, the stimulatory effects of forskolin and chorela toxin showed no significant difference between the original ROS 17/2.8 and transfected cells, but the in vivo osteogenic properties were histologically potentiated in transfectants with increased bone matrix and acceleration of mineralization within tumors.	ros	68-71	parathyroid hormone	Rattus norvegicus	46-49
8806719-4	1996	Actinomycin D (AD) was used as a transcriptional inhibitor to measure the osteocalcin message half-life in ROS 17/2.8 cells.	ros	107-110	bone gamma-carboxyglutamate protein	Rattus norvegicus	74-85
8806719-5	1996	A 24-h treatment of ROS 17/2.8 cells with 1,25(OH)2D3 resulted in prolongation of osteocalcin half-life from 7.0 +/- 1.0 h in untreated cells to 28.0 +/- 0.7 h in the treated cells.	ros	20-23	bone gamma-carboxyglutamate protein	Rattus norvegicus	82-93
8806719-6	1996	Inhibition of protein synthesis by cycloheximide resulted in moderate stabilization of osteocalcin mRNA (t1/2 = 7.7 h in the absence and 14.0 h in the presence of cycloheximide) in ROS 17/2.8 cells.	ros	181-184	bone gamma-carboxyglutamate protein	Rattus norvegicus	87-98
8663211-9	1996	In addition, cotransfection studies in ROS 17/2.8 osteosarcoma cells using an Msx2 expression vector showed that Msx2 inhibits a COL1A1 promoter-chloramphenicol acetyltransferase construct.	ros	39-42	collagen type I alpha 1 chain	Rattus norvegicus	129-135
8760037-6	1996	Upregulation of HSP70 transcription via endogenous PTH receptors also was observed in the osteoblastic cell lines SaOS-2 and ROS 17/2.8.	ros	125-128	parathyroid hormone	Homo sapiens	51-54
8679716-5	1996	In UMR 106 cells 1,25-(OH)2D3 and PTH caused a synergistic up-regulation of the vitamin D receptor (VDR) which was accompanied by a synergistic induction of VDR mRNA expression whereas in both ROS 17/2.8 and MG-63 cells no interaction was observed.	ros	193-196	parathyroid hormone	Rattus norvegicus	34-37
8684002-2	1996	We have studied three B-NHL cell lines (DoHH2, VAL and ROS 50) and show that concurrent activation of BCL2 and MYC may follow translocation of both oncogenes to the same IGH allele.	ros	55-58	BCL2 apoptosis regulator	Homo sapiens	102-106
8679716-12	1996	In ROS 17/2.8 cells PTH as well as stimulation of cAMP production by forskolin enhanced 1,25-(OH)2D3-induced osteocalcin production whereas, as we have shown previously, activation of protein kinase C does not change 1,25-(OH)2D3-stimulated osteocalcin production.	ros	3-6	parathyroid hormone	Rattus norvegicus	20-23
8741521-7	1996	ROS 17/2.8 and MG 63 cells were found to express T beta R-I, T beta R-II, and T beta R-III, and their cell growth was inhibited by TGF-beta, whereas alkaline phosphatase activity was stimulated.	ros	0-3	transforming growth factor beta 1	Homo sapiens	131-139
7649079-0	1995	Structure-function relationship of human parathyroid hormone in the regulation of vitamin D receptor expression in osteoblast-like cells (ROS 17/2.8).	ros	138-141	parathyroid hormone	Homo sapiens	41-60
8634257-4	1996	We have characterized the hydrodynamic properties of Triton X-100 solubilized peripherin/rds-rom-1 complexes from bovine ROS membranes by gel exclusion chromatography on Sepharose C1-6B and velocity sedimentation through H2O- and D2O-based sucrose gradients.	ros	121-124	peripherin	Bos taurus	78-88
8634257-8	1996	The abundance of this complex as measured by competitive ELISA and immunoaffinity purification is approximately 4% of total bovine ROS membrane protein and indicates that peripherin/rds-rom-1 tetramers are present at a relatively high average surface density (ca.	ros	131-134	peripherin	Bos taurus	171-181
8612540-3	1996	5" deletion analysis of rat OC promoter-chloramphenicol acetyltransferase constructs demonstrated that TGF-beta 1 treatment repressed chloramphenicol acetyltransferase activity by 2.4-fold in transient transfections of ROS 17/2.8 cells.	ros	219-222	transforming growth factor, beta 1	Rattus norvegicus	103-113
8612540-8	1996	Our results demonstrate that Fra-2 is hyperphosphorylated upon TGF-beta 1 treatment of ROS 17/2.8 cells.	ros	87-90	transforming growth factor, beta 1	Rattus norvegicus	63-73
8612540-10	1996	Together, these results demonstrate that TGF-beta 1 responsiveness of the rat osteocalcin gene in ROS 17/2.8 cells is mediated through an activator protein-1 like cis-acting element that interacts with Fra-2.	ros	98-101	transforming growth factor, beta 1	Rattus norvegicus	41-51
8612540-10	1996	Together, these results demonstrate that TGF-beta 1 responsiveness of the rat osteocalcin gene in ROS 17/2.8 cells is mediated through an activator protein-1 like cis-acting element that interacts with Fra-2.	ros	98-101	bone gamma-carboxyglutamate protein	Rattus norvegicus	78-89
8612541-7	1996	Gel mobility shift assays show that TGF beta significantly reduces induction of the heterodimers VDR/RXR complexes in 1,25-(OH)2D3-treated ROS 17/2.8 cells.	ros	139-142	transforming growth factor, beta 1	Rattus norvegicus	36-44
9132156-1	1996	The effect of calmodulin on the integral cGMP-activated conductance of ROS plasma membrane has been investigated by using the "patch-clamp" techniques (inside-out configuration).	ros	71-74	calmodulin 1	Homo sapiens	14-24
8603577-13	1996	Thus, important aspects of OC gene transcriptional regulation that cannot be investigated in transient transfection assays can be addressed using ROS 17/2.8 cells stably transfected with OC promoter-reporter constructs.	ros	146-149	bone gamma-carboxyglutamate protein	Rattus norvegicus	27-29
8603577-13	1996	Thus, important aspects of OC gene transcriptional regulation that cannot be investigated in transient transfection assays can be addressed using ROS 17/2.8 cells stably transfected with OC promoter-reporter constructs.	ros	146-149	bone gamma-carboxyglutamate protein	Rattus norvegicus	187-189
8845513-9	1996	Recently, however, one antibody was used to clone the cDNA for the beta-galactoside-binding lectin, galectin 3 or epsilon binding protein (epsilon BP; IgE-binding protein; Mac-2), from a lambda gt11 osteoblast expression library; another was used to clone from an ROS 17/2.8-COS cell expression library the cDNA for OTS-8, a putative target gene of early response genes stimulated in response to phorbol esters in MC3T3-E1 cells.	ros	264-267	lectin, galactose binding, soluble 3	Mus musculus	151-170
8845513-9	1996	Recently, however, one antibody was used to clone the cDNA for the beta-galactoside-binding lectin, galectin 3 or epsilon binding protein (epsilon BP; IgE-binding protein; Mac-2), from a lambda gt11 osteoblast expression library; another was used to clone from an ROS 17/2.8-COS cell expression library the cDNA for OTS-8, a putative target gene of early response genes stimulated in response to phorbol esters in MC3T3-E1 cells.	ros	264-267	lectin, galactose binding, soluble 3	Mus musculus	172-177
7588200-6	1995	C-PTH receptor number was increased up to 2-fold by pretreating ROS 17/2.8 cells with increasing doses of PTH-(1-34), PTH-(1-84), or 8-bromo-cAMP, whereas no change was observed in response to dexamethasone or PTH-(39-84).	ros	64-67	parathyroid hormone	Rattus norvegicus	0-5
7588200-6	1995	C-PTH receptor number was increased up to 2-fold by pretreating ROS 17/2.8 cells with increasing doses of PTH-(1-34), PTH-(1-84), or 8-bromo-cAMP, whereas no change was observed in response to dexamethasone or PTH-(39-84).	ros	64-67	parathyroid hormone	Rattus norvegicus	2-5
7588200-6	1995	C-PTH receptor number was increased up to 2-fold by pretreating ROS 17/2.8 cells with increasing doses of PTH-(1-34), PTH-(1-84), or 8-bromo-cAMP, whereas no change was observed in response to dexamethasone or PTH-(39-84).	ros	64-67	parathyroid hormone	Rattus norvegicus	118-127
7588200-6	1995	C-PTH receptor number was increased up to 2-fold by pretreating ROS 17/2.8 cells with increasing doses of PTH-(1-34), PTH-(1-84), or 8-bromo-cAMP, whereas no change was observed in response to dexamethasone or PTH-(39-84).	ros	64-67	parathyroid hormone	Rattus norvegicus	106-109
9173094-2	1996	Deletion analysis of osteocalcin promoter sequences by transient transfection of osseous (ROS 17/2.8) and nonosseous (R2 fibroblast) cells revealed that the most proximal 108 nucleotides are sufficient to confer tissue-specific expression.	ros	90-93	bone gamma-carboxyglutamate protein	Rattus norvegicus	21-32
9173094-7	1996	First, binding of OCBP correlates with osteocalcin promoter activity in ROS 17/2.8 cells.	ros	72-75	bone gamma-carboxyglutamate protein	Rattus norvegicus	39-50
8664302-2	1996	We have previously shown that in the ROS 17/2.8 rat osteosarcoma cell line, which continuously expresses the osteocalcin gene, key regulatory elements reside in two DNase I hypersensitive sites that are fucntionally correlated with transcriptional activity.	ros	37-40	bone gamma-carboxyglutamate protein	Rattus norvegicus	109-120
8664302-3	1996	We now report that a specific nucleosomal organization supports this constitutive expression in ROS 17/2.8 cells, and that chromatin remodeling directly correlates with the developmentally regulated transcriptional activation of the osteocalcin gene during differentiation of normal diploid rat osteoblasts.	ros	96-99	bone gamma-carboxyglutamate protein	Rattus norvegicus	233-244
8928773-0	1996	Downregulation of the PTH/PTHrP receptor by vitamin D3 in the osteoblast-like ROS 17/2.8 cells.	ros	78-81	parathyroid hormone	Rattus norvegicus	22-25
8928773-1	1996	Effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the expression of the parathyroid hormone (PTH)/PTH-related peptide (rP) receptor protein and mRNA in ROS 17/2.8 cells were studied.	ros	155-158	parathyroid hormone	Rattus norvegicus	75-94
8928773-1	1996	Effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the expression of the parathyroid hormone (PTH)/PTH-related peptide (rP) receptor protein and mRNA in ROS 17/2.8 cells were studied.	ros	155-158	parathyroid hormone	Rattus norvegicus	96-99
8928773-1	1996	Effects of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on the expression of the parathyroid hormone (PTH)/PTH-related peptide (rP) receptor protein and mRNA in ROS 17/2.8 cells were studied.	ros	155-158	parathyroid hormone	Rattus norvegicus	101-104
8928773-2	1996	Treatment of ROS 17/2.8 cells with 1,25(OH)2D3 caused time- and dose-dependent suppression of PTH/PTHrP receptor number and immunoreactivity.	ros	13-16	parathyroid hormone	Rattus norvegicus	94-97
8928773-6	1996	These data indicate that 1,25(OH)2D3 has a potent inhibitory effect on the expression of the PTH/PTHrP receptor protein and mRNA in ROS 17/2.8 cells.	ros	132-135	parathyroid hormone	Rattus norvegicus	93-96
7588294-2	1995	The present study was performed to investigate the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) on the expression of inducible NO-synthase (iNOS) and to measure high-output production of NO by primary rat osteoblasts and osteoblastic cell lines ROS 17/2.8, MC3T3-E1 and MG-63.	ros	317-320	nitric oxide synthase 2	Rattus norvegicus	189-210
7588294-5	1995	Reverse transcription polymerase chain reaction amplified an 807-base pair (bp) product from ROS 17/2.8 cells, which had a size and restriction enzyme-cut pattern identical to that predicted for authentic rat iNOS.	ros	93-96	nitric oxide synthase 2	Rattus norvegicus	209-213
7479833-8	1995	Our results confirm that NMP-1/YY1 is a ubiquitous protein that is present in both human cells and in rat osteosarcoma ROS 17/2.8 cells.	ros	119-122	YY1 transcription factor	Homo sapiens	31-34
7649079-9	1995	Quantitation of VDR messenger RNA by reverse transcription-polymerase chain reaction showed that PTH-(1-34) and -(1-31) at 10(-7) M, but not PTH-(3-34) and -(13-34), inhibited ROS 17/2.8 cell VDR gene expression in both the absence and presence of 1,25-(OH)2D3.	ros	176-179	parathyroid hormone	Homo sapiens	97-100
7628368-9	1995	Similar effects were seen on basic fibroblast growth factor-mediated MAP kinase activation in ROS 17/2.8 cells, indicating that this mechanism is a general feature of PTH in osteosarcoma cells.	ros	94-97	parathyroid hormone	Rattus norvegicus	167-170
8554925-6	1995	Addition of extracellular Fe59-transferrin to cultures of ROS 17/2.8 cells resulted in the sequestration of the iron in intracellular ferritin.	ros	58-61	transferrin	Rattus norvegicus	31-42
7612624-2	1995	Analogues of hPTH-(1-34)-NH2, containing the first 28-31 residues, had only a slightly diminished ability to stimulate AC in rat osteosarcoma (ROS) cells as compared to that of the parent analogue.	ros	143-146	parathyroid hormone	Homo sapiens	13-17
7870034-5	1995	Treatment of ROS osteoblasts with 10 nM 1,25-dihydroxy-vitamin D3 for 14 hr resulted in a significant (&gt; 50%) decrease in 125I-ET-1 and 125I-IRL-1620 binding.	ros	13-16	endothelin 1	Rattus norvegicus	130-134
7619087-1	1995	We have reported that mid-region fragments of human parathyroid hormone (hPTH), exemplified by hPTH-(28-48), stimulated [3H]thymidine incorporation into DNA and increased the specific activity of the brain-type isoenzyme of creatine kinase (CK) in both skeletal-derived cell cultures (ROS 17/2.8 cells) and immature rat epiphyseal cartilage and diaphyseal bone, without stimulating cyclic AMP synthesis which is a prerequisite for bone resorption.	ros	285-288	parathyroid hormone	Homo sapiens	52-71
7619087-1	1995	We have reported that mid-region fragments of human parathyroid hormone (hPTH), exemplified by hPTH-(28-48), stimulated [3H]thymidine incorporation into DNA and increased the specific activity of the brain-type isoenzyme of creatine kinase (CK) in both skeletal-derived cell cultures (ROS 17/2.8 cells) and immature rat epiphyseal cartilage and diaphyseal bone, without stimulating cyclic AMP synthesis which is a prerequisite for bone resorption.	ros	285-288	parathyroid hormone	Homo sapiens	73-77
7619087-1	1995	We have reported that mid-region fragments of human parathyroid hormone (hPTH), exemplified by hPTH-(28-48), stimulated [3H]thymidine incorporation into DNA and increased the specific activity of the brain-type isoenzyme of creatine kinase (CK) in both skeletal-derived cell cultures (ROS 17/2.8 cells) and immature rat epiphyseal cartilage and diaphyseal bone, without stimulating cyclic AMP synthesis which is a prerequisite for bone resorption.	ros	285-288	parathyroid hormone	Homo sapiens	95-99
8587386-1	1995	In this study we examined the participation of cAMP formation in endothelin-1 (ET-1)-induced downregulation of ETB receptor mRNA in ROS 17/2 rat osteosarcoma cells.	ros	132-135	endothelin 1	Rattus norvegicus	65-77
7554919-5	1995	Our studies, using the osteoblastic cell lines ROS 17/2.8 and UMR 106-06, have revealed that the glucocorticoid (10(-8) M dexamethasone; dex) effect on BSP mRNA involves both direct and indirect pathways.	ros	47-50	integrin binding sialoprotein	Homo sapiens	152-155
7721958-10	1995	Further, transfection of 3 kb upstream region of jun-B promoter linked to a CAT reporter gene into ROS 17/2.8 cells was sufficient to be regulated by TGF-beta 1.	ros	99-102	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
7721958-10	1995	Further, transfection of 3 kb upstream region of jun-B promoter linked to a CAT reporter gene into ROS 17/2.8 cells was sufficient to be regulated by TGF-beta 1.	ros	99-102	transforming growth factor, beta 1	Rattus norvegicus	150-160
8587386-1	1995	In this study we examined the participation of cAMP formation in endothelin-1 (ET-1)-induced downregulation of ETB receptor mRNA in ROS 17/2 rat osteosarcoma cells.	ros	132-135	endothelin 1	Rattus norvegicus	79-83
8587386-3	1995	ET-1 induced production of inositol phosphates and an increase of cAMP level in ROS 17/2 cells.	ros	80-83	endothelin 1	Rattus norvegicus	0-4
8587386-7	1995	These results suggest that the ET-1-induced downregulation of ETB receptor mRNA in ROS 17/2 cells may be partly mediated through the increase in cAMP level secondary to the activation of the phosphoinositide hydrolysis/Ca2+ transduction cascade.	ros	83-86	endothelin 1	Rattus norvegicus	31-35
8903933-4	1995	The recombinant mutants were tested for their ability to phosphorylate rhodopsin present in purified bovine ROS membranes which serves as a substrate for betaARK1.	ros	108-111	G protein-coupled receptor kinase 2	Bos taurus	154-162
7809144-2	1994	1,25-Dihydroxyvitamin D3 treatment of ROS 17/2.8 osteoblast-like cells results in a ligand-dependent increase in transcription of the bone-specific osteocalcin gene.	ros	38-41	bone gamma-carboxyglutamate protein	Rattus norvegicus	148-159
7877617-1	1994	We recently defined an element (ACTAATTGG) within the rat osteocalcin (OC) promoter at -84 to -92 which provides approximately 70% of basal promoter activity in osteoblastic cell lines and binds a specific nuclear factor found in OC-producing ROS 17/2.8 osteosarcoma cells.	ros	243-246	bone gamma-carboxyglutamate protein	Rattus norvegicus	58-69
8040186-8	1994	Osteocalcin mRNA levels and synthesis were decreased up to 50% in ROS 17/2.8 cells and in chronically treated (1 and 5 micrograms/ml sodium warfarin) rat osteoblast cultures after 22 days.	ros	66-69	bone gamma-carboxyglutamate protein	Rattus norvegicus	0-11
8194478-4	1994	Gel mobility shift studies of [32P]VDRE binding to ROS 17/2.8 cell nuclear extract revealed that TNF-alpha inhibits 1,25-(OH)2D3 stimulated formation of specific retinoid X receptor/vitamin D receptor (RXR/VDR)-DNA complexes in vitro.	ros	51-54	tumor necrosis factor	Rattus norvegicus	97-106
8079668-2	1994	We have now shown that PTH-(29-32) is the smallest PTH fragment that can stimulate significantly membrane-associated PKC activity in ROS 17/2 rat osteosarcoma cells.	ros	133-136	parathyroid hormone	Rattus norvegicus	23-26
8079668-2	1994	We have now shown that PTH-(29-32) is the smallest PTH fragment that can stimulate significantly membrane-associated PKC activity in ROS 17/2 rat osteosarcoma cells.	ros	133-136	parathyroid hormone	Rattus norvegicus	51-54
9397968-0	1994	Transforming growth factor-beta1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells.	ros	108-111	transforming growth factor, beta 1	Rattus norvegicus	0-32
9397968-4	1994	PTH-stimulated cAMP levels were significantly increased in ROS 17/2.8 cells treated with TGF-beta1 (0.5 ng/ml) for 48 h. These data indicate that TGF-beta1 upregulates steady-state mRNA, ligand binding and PTH/PTHrP receptor signaling in rat osteosarcoma cells.	ros	59-62	transforming growth factor, beta 1	Rattus norvegicus	89-98
9397968-4	1994	PTH-stimulated cAMP levels were significantly increased in ROS 17/2.8 cells treated with TGF-beta1 (0.5 ng/ml) for 48 h. These data indicate that TGF-beta1 upregulates steady-state mRNA, ligand binding and PTH/PTHrP receptor signaling in rat osteosarcoma cells.	ros	59-62	transforming growth factor, beta 1	Rattus norvegicus	146-155
7914821-9	1994	Helodermin and VIP stimulated cAMP accumulation in the cloned mouse calvarial osteoblastic cell line MC3T3-E1, in rat (UMR 106-01), and human (Saos-2) osteoblastic osteosarcoma cell lines, but not in the rat osteosarcoma cell line ROS 17/2.8.	ros	231-234	vasoactive intestinal polypeptide	Mus musculus	15-18
8137738-4	1994	Chronic treatment of ROS 17/2.8 rat osteosarcoma cells with PTH is accompanied by changes in gene expression that are at least in part transcriptionally controlled.	ros	21-24	parathyroid hormone	Rattus norvegicus	60-63
8275958-4	1994	Treatment of ROS 17/2.8 cells with [Nle8,Nle18,Tyr34]bovine PTH-(1-34) amide (NlePTH; 100 nM) alone or together with dexamethasone (1 microM), however, markedly decreased PTH binding and PTH-stimulated cAMP accumulation.	ros	13-16	parathyroid hormone	Rattus norvegicus	60-63
8119149-5	1994	Deletion analysis was performed to identify the sequences mediating the response to TNF alpha in osteoblastic ROS 17/2.8 cells by transient transfection with reporter constructs containing rat OC 5"-flanking DNA [chloramphenicol acetyltransferase (CAT)] that retained or deleted homologous NF kappa B sites or a previously defined 1,25-(OH)2D3 response element (VDRE).	ros	110-113	tumor necrosis factor	Rattus norvegicus	84-93
8125125-4	1994	In addition, the production of reactive oxygen radical species (ROS) of eosinophils after C3a and C5a stimulation was measured by lucigenin-dependent chemiluminescence and quantified by superoxide dismutase-inhibitable reduction of ferricytochrome C. Half maximal and maximal ROS production in response to C3a was observed at 50 ng/ml and 1000 ng/ml, respectively, whereas C3a-desArg was inactive.	ros	64-67	complement C5a receptor 1	Homo sapiens	98-101
8125125-7	1994	In addition, blockade of the C5a receptor by the monoclonal anti-C5a receptor antibody S5/1 totally inhibited the C5a-evoked ROS production, whereas the C3a response in the presence of S5/1 was unaffected.	ros	125-128	complement C5a receptor 1	Homo sapiens	29-41
8125125-7	1994	In addition, blockade of the C5a receptor by the monoclonal anti-C5a receptor antibody S5/1 totally inhibited the C5a-evoked ROS production, whereas the C3a response in the presence of S5/1 was unaffected.	ros	125-128	complement C5a receptor 1	Homo sapiens	29-32
8125125-7	1994	In addition, blockade of the C5a receptor by the monoclonal anti-C5a receptor antibody S5/1 totally inhibited the C5a-evoked ROS production, whereas the C3a response in the presence of S5/1 was unaffected.	ros	125-128	complement C5a receptor 1	Homo sapiens	65-68
8125125-10	1994	Furthermore, the C3a- and C5a-induced production of ROS of eosinophils was totally inhibited by pertussis toxin, indicating the involvement of guanine nucleotide-binding proteins (Gi-proteins).	ros	52-55	complement C5a receptor 1	Homo sapiens	26-29
7857077-3	1994	cDNA clones of PTH/PTHrP receptors from rat osteosarcoma (ROS 17/2.8) and opossum kidney (OK) cells are highly homologous and are members of a novel G protein-linked receptor family that includes calcitonin, glucagon, GLP-1, GHRH, VIP, and secretin receptors.	ros	58-61	parathyroid hormone	Rattus norvegicus	15-18
8112289-2	1994	The pattern of expression of gap junction proteins in these two cell lines was distinct: ROS cells expressed only connexin43 on their cell surface, while UMR expressed predominantly connexin45.	ros	89-92	gap junction protein, alpha 1	Rattus norvegicus	114-124
8112289-6	1994	These studies suggested that Cx43 in ROS cells mediated cell-cell coupling for both small ions and larger molecules, but Cx45 in UMR cells allowed passage only of small ions.	ros	37-40	gap junction protein, alpha 1	Rattus norvegicus	29-33
8275958-0	1994	Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells.	ros	126-129	parathyroid hormone	Rattus norvegicus	14-33
8275958-0	1994	Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells.	ros	126-129	parathyroid hormone	Rattus norvegicus	35-38
8275958-0	1994	Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells.	ros	126-129	parathyroid hormone	Rattus norvegicus	40-43
8275958-0	1994	Regulation of parathyroid hormone (PTH)/PTH-related peptide receptor messenger ribonucleic acid by glucocorticoids and PTH in ROS 17/2.8 and OK cells.	ros	126-129	parathyroid hormone	Rattus norvegicus	40-43
8275958-1	1994	To study mechanisms controlling the expression of PTH/PTH-related peptide (PTHrP) receptors in ROS 17/2.8 and OK cells, we investigated the regulation of PTH/PTHrP receptor availability and receptor mRNA levels by glucocorticoids and PTH.	ros	95-98	parathyroid hormone	Rattus norvegicus	50-53
8275958-2	1994	Treatment of ROS 17/2.8 cells with dexamethasone (1 microM) for 2, 4, and 6 days increased specific binding of PTH to 148 +/- 12%, 203 +/- 10%, and 344 +/- 9% (mean +/- SD), respectively, compared to that in untreated control cells.	ros	13-16	parathyroid hormone	Rattus norvegicus	111-114
8275958-6	1994	As previously reported, daily NlePTH treatment of ROS 17/2.8 cells reduced PTH/PTHrP receptor availability and PTH-stimulated cAMP accumulation markedly within 2 days, which remained at these low levels during continued PTH treatment.	ros	50-53	parathyroid hormone	Rattus norvegicus	33-36
8275958-6	1994	As previously reported, daily NlePTH treatment of ROS 17/2.8 cells reduced PTH/PTHrP receptor availability and PTH-stimulated cAMP accumulation markedly within 2 days, which remained at these low levels during continued PTH treatment.	ros	50-53	parathyroid hormone	Rattus norvegicus	75-78
8275958-6	1994	As previously reported, daily NlePTH treatment of ROS 17/2.8 cells reduced PTH/PTHrP receptor availability and PTH-stimulated cAMP accumulation markedly within 2 days, which remained at these low levels during continued PTH treatment.	ros	50-53	parathyroid hormone	Rattus norvegicus	75-78
8275958-7	1994	In contrast, the identical treatment reduced steady state levels of PTH/PTHrP receptor mRNA in ROS 17/2.8 transiently and to only a slight extent, which then returned to pretreatment levels.	ros	95-98	parathyroid hormone	Rattus norvegicus	68-71
8274878-1	1993	We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	ros	94-97	parathyroid hormone	Rattus norvegicus	59-62
8366144-4	1993	Osteocalcin (OC) mRNA levels were decreased by 61% in ROS 17/2.8 cells and by 97% in differentiated ROB cells.	ros	54-57	bone gamma-carboxyglutamate protein	Rattus norvegicus	0-11
7504868-2	1993	Synthetic oligonucleotide pairs were designed based upon unique regions of the cDNA encoding known PMCA isoforms (PMCA1-3) and used as primers in PCR-mediated amplification of cDNA synthesized from ROS 17/2.8 osteosarcoma cell RNA.	ros	198-201	ATPase plasma membrane Ca2+ transporting 1	Rattus norvegicus	114-121
7689154-4	1993	We report that v-ras and the transforming protein tyrosine kinases v-src, v-yes, and v-ros all increase cellular uPA mRNAs.	ros	52-55	plasminogen activator, urokinase	Gallus gallus	113-116
8352780-7	1993	Moreover, estrogen depletion resulted in marked decrease and increase, respectively, in steady state mRNA levels of TGF-beta 1 and osteocalcin in vitro in osteoblastic rat osteosarcoma cells, ROS 17/2.8.	ros	192-195	transforming growth factor, beta 1	Rattus norvegicus	116-126
8352780-7	1993	Moreover, estrogen depletion resulted in marked decrease and increase, respectively, in steady state mRNA levels of TGF-beta 1 and osteocalcin in vitro in osteoblastic rat osteosarcoma cells, ROS 17/2.8.	ros	192-195	bone gamma-carboxyglutamate protein	Rattus norvegicus	131-142
8274878-7	1993	Our results suggest that the effects of dexamethasone, 1,25(OH)2D3 and PKC on PTH-sensitive adenylate cyclase in ROS 17/2.8 cells are independent of each other.	ros	113-116	parathyroid hormone	Rattus norvegicus	78-81
8395017-7	1993	Increasing concentrations of 9-cis retinoic acid (1 nM to 1 microM) markedly reduced 1,25(OH)2D3-dependent accumulation of osteocalcin mRNA in osteoblast-like ROS 17/2.8 cells.	ros	159-162	bone gamma-carboxyglutamate protein	Rattus norvegicus	123-134
8213262-0	1993	Tumor necrosis factor alpha decreases 1,25-dihydroxyvitamin D3 receptors in osteoblastic ROS 17/2.8 cells.	ros	89-92	tumor necrosis factor	Rattus norvegicus	0-27
8457347-2	1993	As a model system, we looked at the induction of mRNA by parathyroid hormone (PTH) in ROS 17/2.8 rat osteosarcoma cells.	ros	86-89	parathyroid hormone	Rattus norvegicus	57-76
8485727-8	1993	In addition, during growth inhibition of ROS 17/2.8 cells we observe a complex series of modifications in protein/DNA interactions of the osteocalcin gene.	ros	41-44	bone gamma-carboxyglutamate protein	Rattus norvegicus	138-149
8460137-2	1993	In contrast, the OC gene is expressed constitutively in both proliferating and nonproliferating ROS 17/2.8 osteosarcoma cells.	ros	96-99	bone gamma-carboxyglutamate protein	Rattus norvegicus	17-19
8457347-2	1993	As a model system, we looked at the induction of mRNA by parathyroid hormone (PTH) in ROS 17/2.8 rat osteosarcoma cells.	ros	86-89	parathyroid hormone	Rattus norvegicus	78-81
8381250-6	1993	The effects of gallium nitrate on osteocalcin mRNA and protein synthesis mimic those seen when ROS 17/2.8 cells are exposed to transforming growth factor beta 1 (TGF beta 1); however, TGF-beta 1 was not detected in gallium nitrate-treated ROS 17/2.8 cell media.	ros	95-98	bone gamma-carboxyglutamate protein	Rattus norvegicus	34-45
8381250-2	1993	Here we report the effects of gallium nitrate on osteocalcin mRNA and protein levels on the rat osteoblast-like cell line ROS 17/2.8.	ros	122-125	bone gamma-carboxyglutamate protein	Rattus norvegicus	49-60
8381250-6	1993	The effects of gallium nitrate on osteocalcin mRNA and protein synthesis mimic those seen when ROS 17/2.8 cells are exposed to transforming growth factor beta 1 (TGF beta 1); however, TGF-beta 1 was not detected in gallium nitrate-treated ROS 17/2.8 cell media.	ros	95-98	transforming growth factor, beta 1	Rattus norvegicus	127-160
8381250-6	1993	The effects of gallium nitrate on osteocalcin mRNA and protein synthesis mimic those seen when ROS 17/2.8 cells are exposed to transforming growth factor beta 1 (TGF beta 1); however, TGF-beta 1 was not detected in gallium nitrate-treated ROS 17/2.8 cell media.	ros	95-98	transforming growth factor, beta 1	Rattus norvegicus	162-172
1476184-0	1992	Dose-dependent effects of aluminum on osteocalcin synthesis in osteoblast-like ROS 17/2 cells in culture.	ros	79-82	bone gamma-carboxyglutamate protein	Homo sapiens	38-49
1476184-2	1992	After stimulation with various doses of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3; 10(-11) to 10(-9) M], osteocalcin was consistently lower in the culture medium of ROS 17/2 osteoblastic cells conditioned with 5 microM Al(3+)-saturated transferrin (AlTR) than in apotransferrin (ApoTR)-treated controls.	ros	161-164	bone gamma-carboxyglutamate protein	Homo sapiens	101-112
1321277-0	1992	Transforming properties and substrate specificities of the protein tyrosine kinase oncogenes ros and src and their recombinants.	ros	69-72	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	101-104
1384276-10	1992	In the osteoblastic osteosarcoma cell line of rat, ROS 17/2.8, NE (0.1 microM) caused a significant stimulatory action on cyclic AMP formation that was synergistically potentiated by forskolin (3 microM), VIP, CGRP, and SP did not affect the cellular content of cyclic AMP in ROS 17/2.8.	ros	51-54	vasoactive intestinal peptide	Rattus norvegicus	205-208
1321277-4	1992	However, a transforming variant of ROS x SRC II appeared during passages of the transfected cells and was called ROS x SRC (R).	ros	35-38	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	119-122
1321277-4	1992	However, a transforming variant of ROS x SRC II appeared during passages of the transfected cells and was called ROS x SRC (R).	ros	113-116	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	119-122
1321277-5	1992	ROS x SRC (R) contains a 16-amino-acid deletion that includes the 3" half of the transmembrane domain of ros.	ros	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	6-9
1321277-5	1992	ROS x SRC (R) contains a 16-amino-acid deletion that includes the 3" half of the transmembrane domain of ros.	ros	105-108	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	6-9
1321277-10	1992	Data from ros and src recombinants indicate that sequences both inside and outside the catalytic domains of ros and src exert a significant effect on the substrate specificity of the two recombinant proteins.	ros	10-13	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	116-119
1321277-10	1992	Data from ros and src recombinants indicate that sequences both inside and outside the catalytic domains of ros and src exert a significant effect on the substrate specificity of the two recombinant proteins.	ros	108-111	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	18-21
1320001-6	1992	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) did not cause an increase in osteocalcin secretion, while only a small increase in cellular content of osteocalcin in ROS 17/2.8 cells was observed.	ros	179-182	bone gamma-carboxyglutamate protein	Rattus norvegicus	164-175
1644867-10	1992	In contrast, proliferating rat osteosarcoma cells (ROS 17/2.8) concomitantly express histone H4, along with osteopontin and osteocalcin.	ros	51-54	bone gamma-carboxyglutamate protein	Rattus norvegicus	124-135
1321435-2	1992	Protein-DNA interactions at the VDRE of the rat OC gene (nucleotides -466 to -437) are reflected by direct sequence-specific and antibody-sensitive binding of the endogenous vitamin D receptor present in ROS 17/2.8 osteosarcoma nuclear protein extracts.	ros	204-207	bone gamma-carboxyglutamate protein	Rattus norvegicus	48-50
1320001-2	1992	Incubation for 24 h with 1,25(OH)2D3 potently stimulated osteocalcin synthesis by ROS 17/2.8 cells.	ros	82-85	bone gamma-carboxyglutamate protein	Rattus norvegicus	57-68
1319667-4	1992	Incubation of ROS cells with 2 ng/ml of TGF-beta for the maximally effective time of 3 days increased the number of PTH binding sites (Bmax) by 47 +/- 13%, with no change in the KD (3 nM).	ros	14-17	transforming growth factor, beta 1	Rattus norvegicus	40-48
1596781-0	1992	Lead intoxication alters basal and parathyroid hormone-regulated cellular calcium homeostasis in rat osteosarcoma (ROS 17/2.8) cells.	ros	115-118	parathyroid hormone	Rattus norvegicus	35-54
1611299-5	1992	TGF beta also increased alkaline phosphatase activity in two of the cell lines, MG-63 and ROS 17/2.8 but to a greater degree than 1,25(OH)2D3.	ros	90-93	transforming growth factor beta 1	Homo sapiens	0-8
1572285-0	1992	Estrogens modulate the responsiveness of osteoblast-like cells (ROS 17/2.8) stably transfected with estrogen receptor.	ros	64-67	estrogen receptor 1	Homo sapiens	100-117
1319667-7	1992	Since TGF-beta induced comparable increases in both PTH binding and cAMP formation, the findings suggest that TGF-beta can increase the number of functional PTH receptors in cultured ROS 17/2.8 cells.	ros	183-186	transforming growth factor, beta 1	Rattus norvegicus	110-118
1665280-3	1991	Clonal rat osteosarcoma cells, ROS 17/2.8, respond to 1 alpha,25-(OH)2D3 with an increase in osteocalcin message but ROS 24/1 cells do not.	ros	31-34	bone gamma-carboxyglutamate protein	Rattus norvegicus	93-104
1313566-2	1992	Using expression cloning, we have isolated a cDNA clone encoding rat bone PTH/PTHrP receptor from rat osteosarcoma (ROS 17/2.8) cells.	ros	116-119	parathyroid hormone	Rattus norvegicus	74-77
1324516-1	1992	The present study was designed to further understand the role of PTH on the secretion of the neutral metalloproteinases, collagenase and gelatinase, from the rat osteosarcoma clonal cell line, ROS 17/2.8.	ros	193-196	parathyroid hormone	Rattus norvegicus	65-68
1324516-11	1992	This downregulation may represent a specific phenotypic response to PTH in ROS 17/2.8 cells.	ros	75-78	parathyroid hormone	Rattus norvegicus	68-71
1309841-5	1992	In the present studies, IL-1 beta and TNF-alpha both inhibited 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin protein and mRNA by ROS 17/2.8 osteosarcoma cells, whereas IL-6 had no effect on protein and only weakly inhibited mRNA.	ros	145-148	interleukin 1 beta	Rattus norvegicus	24-33
1309841-5	1992	In the present studies, IL-1 beta and TNF-alpha both inhibited 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin protein and mRNA by ROS 17/2.8 osteosarcoma cells, whereas IL-6 had no effect on protein and only weakly inhibited mRNA.	ros	145-148	tumor necrosis factor	Rattus norvegicus	38-47
1309841-5	1992	In the present studies, IL-1 beta and TNF-alpha both inhibited 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin protein and mRNA by ROS 17/2.8 osteosarcoma cells, whereas IL-6 had no effect on protein and only weakly inhibited mRNA.	ros	145-148	bone gamma-carboxyglutamate protein	Rattus norvegicus	113-124
1309841-5	1992	In the present studies, IL-1 beta and TNF-alpha both inhibited 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin protein and mRNA by ROS 17/2.8 osteosarcoma cells, whereas IL-6 had no effect on protein and only weakly inhibited mRNA.	ros	145-148	interleukin 6	Rattus norvegicus	184-188
1309841-9	1992	Despite their lack of promoter regulation, IL-1 alpha and IL-1 beta also stimulated PGE2 production by ROS 17/2.8, further confirming the ability of the host cell to respond to these mediators.	ros	103-106	interleukin 1 alpha	Rattus norvegicus	43-53
1309841-9	1992	Despite their lack of promoter regulation, IL-1 alpha and IL-1 beta also stimulated PGE2 production by ROS 17/2.8, further confirming the ability of the host cell to respond to these mediators.	ros	103-106	interleukin 1 beta	Rattus norvegicus	58-67
1954883-0	1991	Parathyroid hormone (PTH)-induced intracellular Ca2+ signalling in naive and PTH-desensitized osteoblast-like cells (ROS 17/2.8): pharmacological characterization and evidence for synchronous oscillation of intracellular Ca2+.	ros	117-120	parathyroid hormone	Rattus norvegicus	0-19
1954883-0	1991	Parathyroid hormone (PTH)-induced intracellular Ca2+ signalling in naive and PTH-desensitized osteoblast-like cells (ROS 17/2.8): pharmacological characterization and evidence for synchronous oscillation of intracellular Ca2+.	ros	117-120	parathyroid hormone	Rattus norvegicus	21-24
1309253-1	1992	The human insulinlike growth factor 1 (hIGF-1) receptor (hIGFR) is a transmembrane protein tyrosine kinase (PTK) molecule which shares high sequence homology in the PTK domain with the insulin receptor and, to a lesser degree, the ros transforming protein of avian sarcoma virus UR2.	ros	93-96	insulin like growth factor 1	Homo sapiens	10-37
1309253-1	1992	The human insulinlike growth factor 1 (hIGF-1) receptor (hIGFR) is a transmembrane protein tyrosine kinase (PTK) molecule which shares high sequence homology in the PTK domain with the insulin receptor and, to a lesser degree, the ros transforming protein of avian sarcoma virus UR2.	ros	93-96	insulin like growth factor 1	Homo sapiens	39-45
1954883-1	1991	We showed recently that the initial peak cytosolic ionized calcium ([Ca2+]i) response to PTH (2-min exposure) is preserved relative to the cAMP response in osteoblast-like rat osteosarcoma cells (ROS 17/2.8) desensitized by 72-h exposure to PTH.	ros	196-199	parathyroid hormone	Rattus norvegicus	89-92
1954883-3	1991	The [Ca2+]i response to a 20-min perifusion with rat PTH [rPTH-(1-34)] was monitored by aequorin luminescence in both naive and PTH-desensitized ROS 17/2.8 cells.	ros	145-148	parathyroid hormone	Rattus norvegicus	53-56
1954883-3	1991	The [Ca2+]i response to a 20-min perifusion with rat PTH [rPTH-(1-34)] was monitored by aequorin luminescence in both naive and PTH-desensitized ROS 17/2.8 cells.	ros	145-148	parathyroid hormone	Rattus norvegicus	59-62
1659898-11	1991	It appears likely that CaM antagonists prevent an inhibitory multimerization or aggregation of at least one form of ROS phospholipase C.	ros	116-119	calmodulin	Bos taurus	23-26
1863811-8	1991	In contrast, PTH was inhibitory in both RCA 11 and ROS 17/2.8 cells.	ros	51-54	parathyroid hormone	Homo sapiens	13-16
1764418-3	1991	The dephosphorylation of greater than 10(7) phosphorylated rhodopsin molecules/ROS following a bright flash can be blocked by prior dim continuous illumination (generating 10(3) Rho*/ROS/s) that cumulatively bleaches approximately 10(5) rhodopsin molecules/ROS.	ros	79-82	rhodopsin	Homo sapiens	59-68
1764418-3	1991	The dephosphorylation of greater than 10(7) phosphorylated rhodopsin molecules/ROS following a bright flash can be blocked by prior dim continuous illumination (generating 10(3) Rho*/ROS/s) that cumulatively bleaches approximately 10(5) rhodopsin molecules/ROS.	ros	79-82	rhodopsin	Homo sapiens	237-246
1764418-3	1991	The dephosphorylation of greater than 10(7) phosphorylated rhodopsin molecules/ROS following a bright flash can be blocked by prior dim continuous illumination (generating 10(3) Rho*/ROS/s) that cumulatively bleaches approximately 10(5) rhodopsin molecules/ROS.	ros	183-186	rhodopsin	Homo sapiens	59-68
1764418-3	1991	The dephosphorylation of greater than 10(7) phosphorylated rhodopsin molecules/ROS following a bright flash can be blocked by prior dim continuous illumination (generating 10(3) Rho*/ROS/s) that cumulatively bleaches approximately 10(5) rhodopsin molecules/ROS.	ros	183-186	rhodopsin	Homo sapiens	237-246
1764418-3	1991	The dephosphorylation of greater than 10(7) phosphorylated rhodopsin molecules/ROS following a bright flash can be blocked by prior dim continuous illumination (generating 10(3) Rho*/ROS/s) that cumulatively bleaches approximately 10(5) rhodopsin molecules/ROS.	ros	183-186	rhodopsin	Homo sapiens	59-68
1764418-3	1991	The dephosphorylation of greater than 10(7) phosphorylated rhodopsin molecules/ROS following a bright flash can be blocked by prior dim continuous illumination (generating 10(3) Rho*/ROS/s) that cumulatively bleaches approximately 10(5) rhodopsin molecules/ROS.	ros	183-186	rhodopsin	Homo sapiens	237-246
1757481-3	1991	However, dexamethasone significantly inhibits these parameters of the vitamin D-induced upregulation of osteocalcin gene expression in both proliferating and in confluent ROS 17/2.8 cells.	ros	171-174	bone gamma-carboxyglutamate protein	Rattus norvegicus	104-115
1757481-4	1991	In this study, we observed that the extent to which abrogation of the vitamin D response occurs is dependent on basal levels of osteocalcin gene expression as reflected by a complete inhibition of the vitamin D-induced upregulation in a ROS 17/2.8K subline with low basal expression and only a partial reduction of the vitamin D stimulation in a ROS 17/2.8C subline with eightfold higher levels of basal expression.	ros	237-240	bone gamma-carboxyglutamate protein	Rattus norvegicus	128-139
1757481-4	1991	In this study, we observed that the extent to which abrogation of the vitamin D response occurs is dependent on basal levels of osteocalcin gene expression as reflected by a complete inhibition of the vitamin D-induced upregulation in a ROS 17/2.8K subline with low basal expression and only a partial reduction of the vitamin D stimulation in a ROS 17/2.8C subline with eightfold higher levels of basal expression.	ros	346-349	bone gamma-carboxyglutamate protein	Rattus norvegicus	128-139
1714833-7	1991	In parallel studies, ROS 17/2.8 rat osteosarcoma cells released around 50 pg/ml of IL-6 under basal conditions which were increased to a maximum of 900 pg/ml by treatment with PTH (10(-9) M).	ros	21-24	interleukin 6	Rattus norvegicus	83-87
1714833-7	1991	In parallel studies, ROS 17/2.8 rat osteosarcoma cells released around 50 pg/ml of IL-6 under basal conditions which were increased to a maximum of 900 pg/ml by treatment with PTH (10(-9) M).	ros	21-24	parathyroid hormone	Rattus norvegicus	176-179
1913291-0	1991	Dexamethasone-treated ROS 17/2.8 rat osteosarcoma cells are responsive to human carboxylterminal parathyroid hormone peptide hPTH (53-84): stimulation of alkaline phosphatase.	ros	22-25	parathyroid hormone	Homo sapiens	97-116
1913291-0	1991	Dexamethasone-treated ROS 17/2.8 rat osteosarcoma cells are responsive to human carboxylterminal parathyroid hormone peptide hPTH (53-84): stimulation of alkaline phosphatase.	ros	22-25	parathyroid hormone	Homo sapiens	125-129
1913291-2	1991	In dexamethasone-treated ROS 17/2.8 cells there was a dose-related increase in ALP activity due to treatment with hPTH (53-84).	ros	25-28	parathyroid hormone	Homo sapiens	114-118
1708092-1	1991	In this study we demonstrate that retinoic acid (RA) increases the expression of transcription factor zif268 mRNA in primary cultures of fetal rat calvarial cells and in simian virus 40-immortalized clonal rat calvarial preosteoblastic cells (RCT-1), which differentiate in response to RA, but not in the more differentiated RCT-3 and ROS 17/2.8 cells.	ros	335-338	early growth response 1	Rattus norvegicus	102-108
1653893-2	1991	After transient transfection into the osteoblast-like rat osteosarcoma cell line ROS 17/2.8, the BGP promoter demonstrated a low level of basal activity that was increased approximately 10-fold by the addition of 10(-8) M 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].	ros	81-84	bone gamma-carboxyglutamate protein	Rattus norvegicus	97-100
1999144-5	1991	Human TGF-beta over the dose range of 2.5-80 pM significantly stimulated or inhibited soft-agar colony formation of either NRK 49F or A549 cells, respectively, and caused a severalfold increase in biosynthetically labeled [35S]fibronectin in NRK 49F and ROS 17/2.8 cells.	ros	254-257	transforming growth factor beta 1	Homo sapiens	6-14
1999144-7	1991	In addition, covalent cross-linking of intact NRK 49F and ROS 17/2.8 cells with either [125I]TGF-beta or 125I-[Tyr40] PTHrp-(1-40) revealed the presence of several distinct affinity-labeled receptor species for TGF-beta in both cell types and the 80K PTH/PTHrp receptors in ROS 17/2.8 cells.	ros	58-61	transforming growth factor, beta 1	Rattus norvegicus	93-101
1999144-7	1991	In addition, covalent cross-linking of intact NRK 49F and ROS 17/2.8 cells with either [125I]TGF-beta or 125I-[Tyr40] PTHrp-(1-40) revealed the presence of several distinct affinity-labeled receptor species for TGF-beta in both cell types and the 80K PTH/PTHrp receptors in ROS 17/2.8 cells.	ros	58-61	parathyroid hormone	Rattus norvegicus	118-121
2019266-0	1991	Tumor necrosis factor-alpha inhibits 1,25-dihydroxyvitamin D3-stimulated bone Gla protein synthesis in rat osteosarcoma cells (ROS 17/2.8) by a pretranslational mechanism.	ros	127-130	tumor necrosis factor	Rattus norvegicus	0-27
2019266-0	1991	Tumor necrosis factor-alpha inhibits 1,25-dihydroxyvitamin D3-stimulated bone Gla protein synthesis in rat osteosarcoma cells (ROS 17/2.8) by a pretranslational mechanism.	ros	127-130	bone gamma-carboxyglutamate protein	Rattus norvegicus	73-89
2019266-4	1991	To further test this hypothesis and to evaluate the mechanism of TNF alpha action, we studied the effect of TNF alpha on synthesis of the osteoblast-specific bone Gla protein (BGP) by ROS 17/2.8 cells, which have the osteoblast phenotype.	ros	184-187	tumor necrosis factor	Rattus norvegicus	108-117
2019266-4	1991	To further test this hypothesis and to evaluate the mechanism of TNF alpha action, we studied the effect of TNF alpha on synthesis of the osteoblast-specific bone Gla protein (BGP) by ROS 17/2.8 cells, which have the osteoblast phenotype.	ros	184-187	bone gamma-carboxyglutamate protein	Rattus norvegicus	158-174
2019266-4	1991	To further test this hypothesis and to evaluate the mechanism of TNF alpha action, we studied the effect of TNF alpha on synthesis of the osteoblast-specific bone Gla protein (BGP) by ROS 17/2.8 cells, which have the osteoblast phenotype.	ros	184-187	bone gamma-carboxyglutamate protein	Rattus norvegicus	176-179
2065504-2	1991	Tissue culture experiments have demonstrated that BGP is synthesized by two osteoblastic osteosarcoma cell lines (ROS 2/3 and 17/2) and by normal osteoblastic cells in primary culture.	ros	114-117	bone gamma-carboxyglutamate protein	Rattus norvegicus	50-53
1985893-3	1991	We measured K+ fluxes associated with the Ca-Ca self-exchange mode of the Na-Ca exchanger to corroborate our previous conclusion that the ROS Na-Ca exchanger differs from Na-Ca exchangers in other tissues by its ability to transport K+ (Schnetkamp, P. P. M., Basu, D. K. &amp; Szerencsei, R. T. (1989) Am.	ros	138-141	nascent polypeptide-associated complex subunit alpha	Bos taurus	74-79
1846574-10	1991	Thus, 1) the cAMP and [Ca2+]i responses of ROS 17/2.8 cells to rPTH-(1-34) are not obligatorily coupled; 2) the response of naive cells to PTH includes both the release of Ca2+ from intracellular stores and the entry of extracellular Ca2+; and 3) pretreatment of these cells with rPTH-(1-34) augments the dependence on Ca2+ entry during hormone rechallenge.	ros	43-46	parathyroid hormone	Rattus norvegicus	64-67
1985893-3	1991	We measured K+ fluxes associated with the Ca-Ca self-exchange mode of the Na-Ca exchanger to corroborate our previous conclusion that the ROS Na-Ca exchanger differs from Na-Ca exchangers in other tissues by its ability to transport K+ (Schnetkamp, P. P. M., Basu, D. K. &amp; Szerencsei, R. T. (1989) Am.	ros	138-141	nascent polypeptide-associated complex subunit alpha	Bos taurus	142-147
1985893-3	1991	We measured K+ fluxes associated with the Ca-Ca self-exchange mode of the Na-Ca exchanger to corroborate our previous conclusion that the ROS Na-Ca exchanger differs from Na-Ca exchangers in other tissues by its ability to transport K+ (Schnetkamp, P. P. M., Basu, D. K. &amp; Szerencsei, R. T. (1989) Am.	ros	138-141	nascent polypeptide-associated complex subunit alpha	Bos taurus	142-147
1702922-7	1990	AA and 1,25-(OH)2D3 had similar effects on ALP activity in ROS 17/2.8 rat osteosarcoma cells.	ros	59-62	alkaline phosphatase, placental	Homo sapiens	43-46
2176478-3	1990	In the present study of mammalian systems, we demonstrate differential effects of defined synthetic PTH fragments on CK activity and DNA synthesis, as compared with cyclic AMP production, in osteoblast-enriched embryonic rat calvaria cell cultures, in an osteoblast-like clone of rat osteosarcoma cells (ROS 17/2.8) and in chondroblasts from rat epiphysial cartilage cell cultures.	ros	304-307	parathyroid hormone	Homo sapiens	100-103
2176478-6	1990	The increase of CK activity in ROS 17/2.8 cells caused by bPTH-(1-84) or hPTH-(28-48) was completely inhibited by either cycloheximide or actinomycin D, as was shown previously for rat calvaria cell cultures.	ros	31-34	parathyroid hormone	Homo sapiens	73-77
1725676-8	1991	In an in vitro study of osteoblastic cells (UMR 106-01, ROS 17/2.8, Saos-2, MC3T3-E1) receptors to CGRP, VIP, noradrenaline (NA) and NPY were demonstrated as assessed by analysis of cyclic AMP formation.	ros	56-59	vasoactive intestinal peptide	Rattus norvegicus	105-108
2226314-5	1990	1,25(OH)2D3 also increased [Ca2+]i in ROS 24/1 cells, which are defective of receptors for the vitamin D metabolites.	ros	38-41	carbonic anhydrase 2	Rattus norvegicus	28-31
2226314-6	1990	At high doses (10(-8)-10(-7) M) of 1,25(OH)2D3 the [Ca2+]i rise in ROS 17/2.8 cells was due to both influx of extracellular Ca2+ and release of Ca2+ from intracellular stores, as the effect was only partially inhibited by Ca2(+)-channel blockade by nifedipine.	ros	67-70	carbonic anhydrase 2	Rattus norvegicus	52-55
2226314-6	1990	At high doses (10(-8)-10(-7) M) of 1,25(OH)2D3 the [Ca2+]i rise in ROS 17/2.8 cells was due to both influx of extracellular Ca2+ and release of Ca2+ from intracellular stores, as the effect was only partially inhibited by Ca2(+)-channel blockade by nifedipine.	ros	67-70	carbonic anhydrase 2	Rattus norvegicus	124-127
2226314-6	1990	At high doses (10(-8)-10(-7) M) of 1,25(OH)2D3 the [Ca2+]i rise in ROS 17/2.8 cells was due to both influx of extracellular Ca2+ and release of Ca2+ from intracellular stores, as the effect was only partially inhibited by Ca2(+)-channel blockade by nifedipine.	ros	67-70	carbonic anhydrase 2	Rattus norvegicus	124-127
2226314-6	1990	At high doses (10(-8)-10(-7) M) of 1,25(OH)2D3 the [Ca2+]i rise in ROS 17/2.8 cells was due to both influx of extracellular Ca2+ and release of Ca2+ from intracellular stores, as the effect was only partially inhibited by Ca2(+)-channel blockade by nifedipine.	ros	67-70	carbonic anhydrase 2	Rattus norvegicus	124-127
2246323-2	1990	TGF beta has been shown to stimulate alkaline phosphatase (ALPase) activity in the rat osteoblast-like osteosarcoma cell line ROS 17/2.8.	ros	126-129	transforming growth factor, beta 1	Rattus norvegicus	0-8
2164926-5	1990	Treatment of ROS cells with PTH (0-5 nM) resulted in a dose and time-dependent decline in VDR from 95 +/- 9 to 35 +/- 5 fmol/mg protein at 18 h of exposure.	ros	13-16	parathyroid hormone	Rattus norvegicus	28-31
2256116-0	1990	Lead impairs the production of osteocalcin by rat osteosarcoma (ROS 17/2.8) cells.	ros	64-67	bone gamma-carboxyglutamate protein	Rattus norvegicus	31-42
2256116-7	1990	These data indicate that lead attenuates basal and 1,25-dihydroxyvitamin D3-stimulated production of osteocalcin in ROS 17/2.8 cells.	ros	116-119	bone gamma-carboxyglutamate protein	Rattus norvegicus	101-112
2169314-0	1990	Effect of lead on parathyroid hormone-induced responses in rat osteoblastic osteosarcoma cells (ROS 17/2.8) using 19F-NMR.	ros	96-99	parathyroid hormone	Rattus norvegicus	18-37
2169314-6	1990	In this study, we have examined the effects of Pb2+ on the basal and parathyroid hormone (PTH)-stimulated levels of [Ca2+]i and cAMP in cultured ROS 17/2.8 cells.	ros	145-148	parathyroid hormone	Rattus norvegicus	69-88
2169314-6	1990	In this study, we have examined the effects of Pb2+ on the basal and parathyroid hormone (PTH)-stimulated levels of [Ca2+]i and cAMP in cultured ROS 17/2.8 cells.	ros	145-148	parathyroid hormone	Rattus norvegicus	90-93
2115429-3	1990	Since serum levels of bone gla protein (BGP) have been correlated with the bone formation rate, we studied the effect of IFN on production of this osteoblast-specific protein and steady state BGP messenger RNA (mRNA) levels in ROS 17/2.8 cells.	ros	227-230	bone gamma-carboxyglutamate protein	Rattus norvegicus	192-195
2160773-1	1990	Binding of 125I-labeled rat (r) PTH-(1-34) to ROS 17/2.8 osteoblastic bone cells and to membranes from these cells was examined.	ros	46-49	parathyroid hormone	Rattus norvegicus	32-35
2163326-0	1990	Treatment of bone-derived ROS 17/2.8 cells with dexamethasone and pertussis toxin enables detection of partial agonist activity for parathyroid hormone antagonists.	ros	26-29	parathyroid hormone	Rattus norvegicus	132-151
2252808-10	1990	These data indicate that PHT affects osteocalcin secretion from osteoblastic rat osteosarcoma (ROS 17/2.8) cells.	ros	95-98	bone gamma-carboxyglutamate protein	Rattus norvegicus	37-48
2308930-2	1990	Stimulation of osteocalcin gene expression by 1,25-dihydroxyvitamin D3, a physiologic mediator of this bone-specific gene in vitro and in vivo, is associated with modifications in the binding of ROS 17/2.8 cell nuclear factors to two promoter segments that up-regulate transcription.	ros	195-198	bone gamma-carboxyglutamate protein	Rattus norvegicus	15-26
2154457-0	1990	Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.	ros	124-127	insulin	Homo sapiens	13-20
2154457-0	1990	Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.	ros	124-127	insulin	Homo sapiens	105-112
33775773-2	2021	Massive ROS production can induce cell death or activate protective pathways such as Keap1/Nrf2 pathway, which regulates intracellular cysteine availability through upregulation of SLC7A11, a subunit of xCT transporter, and subsequently glutathione synthesis, thus improving antioxidative defense.	ros	8-11	kelch like ECH associated protein 1	Homo sapiens	85-90
33765242-8	2021	ROS level was decreased but ATP content increased in HEK-S cells.	ros	0-3	EPH receptor A3	Homo sapiens	53-58
33775773-2	2021	Massive ROS production can induce cell death or activate protective pathways such as Keap1/Nrf2 pathway, which regulates intracellular cysteine availability through upregulation of SLC7A11, a subunit of xCT transporter, and subsequently glutathione synthesis, thus improving antioxidative defense.	ros	8-11	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
33812688-0	2021	Corrigendum to "Aspirin eugenol ester ameliorates paraquat-induced oxidative damage through ROS/p38-MAPK-mediated mitochondrial apoptosis pathway" [Toxicology 453 (2021) 152721].	ros	92-95	mitogen-activated protein kinase 14	Homo sapiens	96-104
33773140-0	2021	Asenapine maleate inhibits angiotensin II-induced proliferation and activation of cardiac fibroblasts via the ROS/TGFbeta1/MAPK signaling pathway.	ros	110-113	angiotensinogen	Homo sapiens	27-41
33820818-5	2021	Investigation revealed that infection-induced transient ROS production dissociates NRF2 from its inhibitor KEAP1 and enabled phosphorylation-dependent nuclear translocation.	ros	56-59	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
33939975-0	2021	A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways.	ros	49-52	mitogen-activated protein kinase 8	Homo sapiens	95-98
33939975-0	2021	A new synthetic antitumor naphthoquinone induces ROS-mediated apoptosis with activation of the JNK and p38 signaling pathways.	ros	49-52	mitogen-activated protein kinase 1	Homo sapiens	103-106
33798806-11	2021	Moreover, FOXO4 reduced the serum endotoxin, biochemical parameters (ALT, AST, ALP and TG), antioxidant enzymes (ROS and MDA), inflammatory cytokines (IL-6, IL-1beta, and TNF-alpha), but restored the levels of GSH, SOD and IL-10.	ros	113-116	forkhead box O4	Mus musculus	10-15
33819194-8	2021	In addition, PRDX2 knockdown led to increased ROS production in CD133+CD44+ CCSCs, sensitizing CCSCs to oxidative stress and chemotherapy.	ros	46-49	peroxiredoxin 2	Homo sapiens	13-18
33767132-6	2021	We also showed that the increase in reactive oxidative species (ROS) in hypoxia-treated HK2 cells was attenuated by treatment with FXR agonist or by FXR overexpression, and that the level of ROS was elevated in FXR-deficient cells and mice.	ros	64-67	nuclear receptor subfamily 1, group H, member 4	Mus musculus	131-134
33767132-6	2021	We also showed that the increase in reactive oxidative species (ROS) in hypoxia-treated HK2 cells was attenuated by treatment with FXR agonist or by FXR overexpression, and that the level of ROS was elevated in FXR-deficient cells and mice.	ros	64-67	nuclear receptor subfamily 1, group H, member 4	Mus musculus	149-152
33767132-6	2021	We also showed that the increase in reactive oxidative species (ROS) in hypoxia-treated HK2 cells was attenuated by treatment with FXR agonist or by FXR overexpression, and that the level of ROS was elevated in FXR-deficient cells and mice.	ros	64-67	nuclear receptor subfamily 1, group H, member 4	Mus musculus	149-152
33767132-6	2021	We also showed that the increase in reactive oxidative species (ROS) in hypoxia-treated HK2 cells was attenuated by treatment with FXR agonist or by FXR overexpression, and that the level of ROS was elevated in FXR-deficient cells and mice.	ros	191-194	nuclear receptor subfamily 1, group H, member 4	Mus musculus	131-134
33767132-6	2021	We also showed that the increase in reactive oxidative species (ROS) in hypoxia-treated HK2 cells was attenuated by treatment with FXR agonist or by FXR overexpression, and that the level of ROS was elevated in FXR-deficient cells and mice.	ros	191-194	nuclear receptor subfamily 1, group H, member 4	Mus musculus	149-152
33767132-6	2021	We also showed that the increase in reactive oxidative species (ROS) in hypoxia-treated HK2 cells was attenuated by treatment with FXR agonist or by FXR overexpression, and that the level of ROS was elevated in FXR-deficient cells and mice.	ros	191-194	nuclear receptor subfamily 1, group H, member 4	Mus musculus	149-152
33791071-0	2021	Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells.	ros	79-82	AKT serine/threonine kinase 1	Homo sapiens	93-96
33815107-12	2021	Additionally, AE@NPs could also activate the ROS-p38 axis, which is not observed in the single drug treatments.	ros	45-48	mitogen-activated protein kinase 14	Homo sapiens	49-52
33815107-13	2021	Collectively, the AE@NPs prepared in this study possess great potential for pancreatic cancer treatment by dual suppressing of EGFR and STAT3 pathways and activating ROS-responsive p38 MAPK pathway.	ros	166-169	signal transducer and activator of transcription 3	Homo sapiens	136-141
33791071-0	2021	Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells.	ros	79-82	mechanistic target of rapamycin kinase	Homo sapiens	97-101
33791071-12	2021	Finally, BCT-100 was demonstrated to induce autophagy and apoptosis via the ROS-mediated AKT/mTOR signaling pathway in bladder cancer cells.	ros	76-79	AKT serine/threonine kinase 1	Homo sapiens	89-92
33791071-12	2021	Finally, BCT-100 was demonstrated to induce autophagy and apoptosis via the ROS-mediated AKT/mTOR signaling pathway in bladder cancer cells.	ros	76-79	mechanistic target of rapamycin kinase	Homo sapiens	93-97
8070362-1	1994	Previously, we reported that [Arg2]PTH-(1-34) bound to the rat osteosarcoma cell line, ROS 17/2.8, with 2-fold higher apparent affinity than it did to the opossum kidney cell line, OK, yet the analog was only a weak partial agonist for cAMP stimulation with ROS 17/2.8 cells, whereas it was a full cAMP agonist with OK cells.	ros	87-90	parathyroid hormone	Rattus norvegicus	35-38
33799790-0	2021	Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells.	ros	140-143	AKT serine/threonine kinase 1	Homo sapiens	112-115
33799790-0	2021	Tioconazole and Chloroquine Act Synergistically to Combat Doxorubicin-Induced Toxicity via Inactivation of PI3K/AKT/mTOR Signaling Mediated ROS-Dependent Apoptosis and Autophagic Flux Inhibition in MCF-7 Breast Cancer Cells.	ros	140-143	mechanistic target of rapamycin kinase	Homo sapiens	116-120
33799790-8	2021	Additionally, CQ and/or TIC combination therapy with DOX exerts its activity on the redox balance of cancer cells mediated ROS-dependent apoptosis induction achieved by GPX3 suppression.	ros	123-126	glutathione peroxidase 3	Homo sapiens	169-173
33785100-6	2021	The results proved the presence of ROS that triggered the intrinsic apoptotic pathway, which was confirmed through a decrease in (Bcl-2), the release of cytochrome c, activation of caspase-9, and caspase-3.	ros	35-38	BCL2 apoptosis regulator	Homo sapiens	130-135
33785100-6	2021	The results proved the presence of ROS that triggered the intrinsic apoptotic pathway, which was confirmed through a decrease in (Bcl-2), the release of cytochrome c, activation of caspase-9, and caspase-3.	ros	35-38	cytochrome c, somatic	Homo sapiens	153-165
33777322-9	2021	Rather, linalool decreased Abeta-induced ROS levels, oxidative stress, and inflammatory response in the brains of AD model flies.	ros	41-44	amyloid beta precursor protein	Homo sapiens	27-32
33785100-6	2021	The results proved the presence of ROS that triggered the intrinsic apoptotic pathway, which was confirmed through a decrease in (Bcl-2), the release of cytochrome c, activation of caspase-9, and caspase-3.	ros	35-38	caspase 3	Homo sapiens	196-205
33232882-7	2020	The treatment of RR cells with Nrf2 inhibitor resulted in decreased clonogenic survival indicating their addiction to Nrf2 for metabolic adaptations under high levels of cytosolic ROS.	ros	180-183	NFE2 like bZIP transcription factor 2	Homo sapiens	31-35
33232882-7	2020	The treatment of RR cells with Nrf2 inhibitor resulted in decreased clonogenic survival indicating their addiction to Nrf2 for metabolic adaptations under high levels of cytosolic ROS.	ros	180-183	NFE2 like bZIP transcription factor 2	Homo sapiens	118-122
8070362-1	1994	Previously, we reported that [Arg2]PTH-(1-34) bound to the rat osteosarcoma cell line, ROS 17/2.8, with 2-fold higher apparent affinity than it did to the opossum kidney cell line, OK, yet the analog was only a weak partial agonist for cAMP stimulation with ROS 17/2.8 cells, whereas it was a full cAMP agonist with OK cells.	ros	258-261	parathyroid hormone	Rattus norvegicus	35-38
8070362-3	1994	In this report we show that the cloned PTH receptors derived from ROS 17/2.8 and OK cells, expressed in COS-7 cells, also displayed altered responses to [Arg2]PTH-(1-34).	ros	66-69	parathyroid hormone	Rattus norvegicus	39-42
8070362-3	1994	In this report we show that the cloned PTH receptors derived from ROS 17/2.8 and OK cells, expressed in COS-7 cells, also displayed altered responses to [Arg2]PTH-(1-34).	ros	66-69	parathyroid hormone	Rattus norvegicus	159-162
34915285-6	2022	Further studies found thatYH-9could induce the release of cytochrome c and inhibit proliferation by promoting ROS expression in SK-BR-3 cells.	ros	110-113	cytochrome c, somatic	Homo sapiens	58-70
34844806-4	2022	Moreover, MP20 released more organic compounds (TOC 1.6 mg/g-MP20, versus 0.2 mg/g-MP0 in 4 h) -possibly depolymerization byproducts (verified by GC-MS), which induced intracellular ROS generation, increased cell permeability and upregulated HGT associated genes.	ros	182-185	lens intrinsic membrane protein 2	Homo sapiens	10-14
34952043-10	2022	Similarly, inhibition of EZH2 using 3-DZNeP or shRNA restored cell viability, suppressed LDH release and the production of intracellular ROS in vitro.	ros	137-140	enhancer of zeste 2 polycomb repressive complex 2 subunit	Rattus norvegicus	25-29
34593974-4	2022	Due to the critical role of ROS in neuroinflammation, we speculated that HACE1 might participate in neuroinflammation and related neurodegenerative diseases, such as PD.	ros	28-31	HECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1	Mus musculus	73-78
34890707-8	2022	ROS and ROS/MAPK (Erk1/2, p38) functioned as the upstream signaling molecules in the activation of NF-kappaB and AP-1, respectively.	ros	0-3	nuclear factor kappa B subunit 1	Homo sapiens	99-108
34785090-0	2022	Corrigendum to "TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARgamma-SIRT1 feedback loop in human bladder cancer cells" (Cancer Lett.	ros	59-62	transmembrane 4 superfamily member 1	Mus musculus	16-22
34890707-8	2022	ROS and ROS/MAPK (Erk1/2, p38) functioned as the upstream signaling molecules in the activation of NF-kappaB and AP-1, respectively.	ros	8-11	mitogen-activated protein kinase 3	Homo sapiens	18-24
34890707-8	2022	ROS and ROS/MAPK (Erk1/2, p38) functioned as the upstream signaling molecules in the activation of NF-kappaB and AP-1, respectively.	ros	8-11	mitogen-activated protein kinase 1	Homo sapiens	26-29
34890707-8	2022	ROS and ROS/MAPK (Erk1/2, p38) functioned as the upstream signaling molecules in the activation of NF-kappaB and AP-1, respectively.	ros	8-11	nuclear factor kappa B subunit 1	Homo sapiens	99-108
34883284-4	2022	Then, we find knockdown of BNIP3 with SiRNA obviously prevents silibinin-induced DNA DSBs and ROS accumulation.	ros	94-97	BCL2 interacting protein 3	Homo sapiens	27-32
34902437-13	2022	SIGNIFICANCE: To summarize, the protective effect of PSTi8 on FFA-induced insulin resistance is mediated via inhibition of JNK signaling, which leads to decreased ROS generation and enhanced insulin sensitivity.	ros	163-166	insulin	Homo sapiens	74-81
34883284-7	2022	Given that activated mTOR could promote xCT expression and inhibit autophagic degradation of catalase, our data suggest that BNIP3 contributes to silibinin-induced DNA DSBs via improving intracellular ROS by inhibition of mTOR.	ros	201-204	BCL2 interacting protein 3	Homo sapiens	125-130
34896468-0	2022	Curcin C inhibit osteosarcoma cell line U2OS proliferation by ROS induced apoptosis, autophagy and cell cycle arrest through activating JNK signal pathway.	ros	62-65	mitogen-activated protein kinase 8	Homo sapiens	136-139
34902437-12	2022	Furthermore, gene expression studies indicate that PSTi8 treatment reduces NADPH oxidase3 (NOX3) expression and inhibits JNK signaling, a predominant source of ROS-induced insulin resistance.	ros	160-163	mitogen-activated protein kinase 8	Homo sapiens	121-124
34902437-12	2022	Furthermore, gene expression studies indicate that PSTi8 treatment reduces NADPH oxidase3 (NOX3) expression and inhibits JNK signaling, a predominant source of ROS-induced insulin resistance.	ros	160-163	insulin	Homo sapiens	172-179
34902437-13	2022	SIGNIFICANCE: To summarize, the protective effect of PSTi8 on FFA-induced insulin resistance is mediated via inhibition of JNK signaling, which leads to decreased ROS generation and enhanced insulin sensitivity.	ros	163-166	mitogen-activated protein kinase 8	Homo sapiens	123-126
34822966-7	2022	The Cat/Re@PLGA@UCM NPs also exhibited outstanding ROS scavenging properties, downregulating ICAM-1, TNF-alpha and IL-1beta, while preventing angiogenesis to attenuate the progression of AS.	ros	51-54	catalase	Homo sapiens	4-7
34530165-0	2022	CLE14 functions as a "brake signal" suppressing age-dependent and stress-induced leaf senescence through promoting JUB1-mediated ROS scavenge in Arabidopsis.	ros	129-132	NAC domain containing protein 42	Arabidopsis thaliana	115-119
34530165-11	2022	Notably, the function of CLE14 peptides was JUB1-dependent in delaying leaf senescence, reducing H2O2 level, and activating ROS scavenging genes.	ros	124-127	NAC domain containing protein 42	Arabidopsis thaliana	44-48
34822966-7	2022	The Cat/Re@PLGA@UCM NPs also exhibited outstanding ROS scavenging properties, downregulating ICAM-1, TNF-alpha and IL-1beta, while preventing angiogenesis to attenuate the progression of AS.	ros	51-54	tumor necrosis factor	Homo sapiens	101-110
34530165-12	2022	We propose that small peptide CLE14 serves as a novel "brake signal" in regulating age-dependent and stress-induced leaf senescence through JUB1-mediated ROS scavenging.	ros	154-157	NAC domain containing protein 42	Arabidopsis thaliana	140-144
34963561-4	2022	In addition, DNR induced NOX4-dependent ROS production, leading to the activation of p38 MAPK and inactivation of Akt and ERK.	ros	40-43	AKT serine/threonine kinase 1	Homo sapiens	114-117
34963561-4	2022	In addition, DNR induced NOX4-dependent ROS production, leading to the activation of p38 MAPK and inactivation of Akt and ERK.	ros	40-43	mitogen-activated protein kinase 1	Homo sapiens	122-125
34634178-12	2022	Odoroside A and its derivative inhibited the growth of leukaemia by inducing apoptosis and autophagy through the activation of ROS-JNK pathway.	ros	127-130	mitogen-activated protein kinase 8	Homo sapiens	131-134
34823019-3	2022	Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a vital role in regulating metabolism, mitochondrial function, and the ROS-dependent adaptations of skeletal muscle, as the response to exercise.	ros	128-131	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-43
34863979-5	2022	NOX4-stimulated ROS generation led to JNK-mediated phosphorylation of cytosolic HuR at Ser221, thereby increasing TNF-alpha protein expression by stabilizing TNF-alpha mRNA.	ros	16-19	mitogen-activated protein kinase 8	Homo sapiens	38-41
34863979-5	2022	NOX4-stimulated ROS generation led to JNK-mediated phosphorylation of cytosolic HuR at Ser221, thereby increasing TNF-alpha protein expression by stabilizing TNF-alpha mRNA.	ros	16-19	tumor necrosis factor	Homo sapiens	114-123
34863979-5	2022	NOX4-stimulated ROS generation led to JNK-mediated phosphorylation of cytosolic HuR at Ser221, thereby increasing TNF-alpha protein expression by stabilizing TNF-alpha mRNA.	ros	16-19	tumor necrosis factor	Homo sapiens	158-167
34742454-2	2022	In this study, a carboxymethyl chitosan-based pH/hypoxia-responsive and gamma-Fe2O3/isosorbide dinitrate carrying micelle was designed, and it could catalyze endogenous H2O2 to generate oxygen and relieve hypoxia in TME, so as to relieve the overexpression of HIF-1alpha and PD-L1 in tumor; meanwhile, it could react with H2O2 to release ROS via Fenton reaction and induce cytotoxicity in tumor.	ros	338-341	hypoxia inducible factor 1 subunit alpha	Homo sapiens	260-270
34673249-5	2022	ROS accumulation in the bodies further caused the contents of MDA, protein carbonyl and lipofuscin to increase significantly, the mitochondrial membrane potential to be severely damaged, apoptosis to occur, and the apoptosis genes ced-3 and ced-4 to be significantly upregulated.	ros	0-3	Cell death protein 3 subunit p17	Caenorhabditis elegans	231-236
34784561-0	2022	MiR-1294 suppresses ROS-dependent inflammatory response in atopic dermatitis via restraining STAT3/NF-kappaB pathway.	ros	20-23	signal transducer and activator of transcription 3	Mus musculus	93-98
34784561-0	2022	MiR-1294 suppresses ROS-dependent inflammatory response in atopic dermatitis via restraining STAT3/NF-kappaB pathway.	ros	20-23	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
34450372-8	2022	However, the significantly decreased of ape-1 and sod-3 expression indicated the disruption of ROS defense mechanism.	ros	95-98	Apoptotic enhancer 1 protein	Caenorhabditis elegans	40-45
34823019-3	2022	Nuclear factor erythroid 2-related factor 2 (Nrf2) plays a vital role in regulating metabolism, mitochondrial function, and the ROS-dependent adaptations of skeletal muscle, as the response to exercise.	ros	128-131	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
34843737-8	2022	Pretreating cultured keratinocytes with antioxidant or AKT inhibitor significantly reduced the UVB-induced ROS, cell proliferation, and pAKT expression.	ros	107-110	AKT serine/threonine kinase 1	Homo sapiens	55-58
34854954-8	2022	Moreover, we found that ROS inhibition via NAC effectively blocks NLRP3 activation and pyroptosis.	ros	24-27	NLR family pyrin domain containing 3	Homo sapiens	66-71
34847624-0	2022	Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.	ros	62-65	AKT serine/threonine kinase 1	Homo sapiens	81-84
34674139-7	2022	The addition of exogenous drugs to manipulate the intracellular ROS and its effect on NRF2 pathway genes was also investigated.	ros	64-67	NFE2 like bZIP transcription factor 2	Homo sapiens	86-90
34808482-7	2022	We found that the production of inflammatory factors, PGE2, and COX-2 was significantly elevated in IL-17A-treated mast cells, accompanied by the activation of the iNOS/NO axis and the elevated secretion of ROS.	ros	207-210	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
34847624-0	2022	Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.	ros	62-65	mechanistic target of rapamycin kinase	Homo sapiens	85-89
34847624-9	2022	The study provides evidence that alnustone is effective against HCC via ROS-mediated PI3K/Akt/mTOR/p70S6K pathway and the compound has the potential to be developed as a novel anticancer agent for the treatment of HCC clinically.	ros	72-75	thymoma viral proto-oncogene 1	Mus musculus	90-93
34965422-4	2021	Meanwhile, ROS dramatically increases PD-L1 mRNA levels through accelerating expression of the transcription factor NRF2.	ros	11-14	NFE2 like bZIP transcription factor 2	Homo sapiens	116-120
34715543-6	2022	When Nrf2 was inhibited, more cell death occurred in TM4 cells post heat stress treatment, along with a greater decrease in cell viability and a significant increase in intracellular ROS levels.	ros	183-186	nuclear factor, erythroid derived 2, like 2	Mus musculus	5-9
34936717-7	2022	Further study showed that TRIM7 affected HIF-1alpha accumulation though targeting either the Src-triggered PI3K/AKT/mTOR signaling pathway or ROS production.	ros	142-145	tripartite motif containing 7	Homo sapiens	26-31
34992716-4	2021	A set of processes leading to this outcome starts with the generation of ROS, attributed to the interaction of Pt with complex I of the mitochondrial respiratory chain, and spreads to involve Ca2+ mobilization from the ER/mitochondria pool, activation of CREB and AMPK, and inhibition of mTORC1.	ros	73-76	cAMP responsive element binding protein 1	Mus musculus	255-259
34959258-0	2022	Correction: Enhanced phototoxicity of photodynamic treatment by Cx26-composed GJIC via ROS-, calcium- and lipid peroxide-mediated pathways.	ros	87-90	gap junction protein beta 2	Homo sapiens	64-68
34941874-12	2021	Additionally, PNU282987 suppressed NF-kappaB/NLRP3 inflammasome activation by inhibiting the ROS/TXNIP pathway and suppressed tumor necrosis factor-alpha and IL-1beta secretion in MIA/IL-1beta-treated chondrocytes.	ros	93-96	NLR family, pyrin domain containing 3	Rattus norvegicus	45-50
34951363-5	2021	Signaling pathways such as NF-kappaB, MAPKs, PI3K/Akt/ mTOR and Keap1-Nrf2-ARE modulates the detrimental effects of oxidative stress by increasing the expression of cellular antioxidant defenses, phase II detoxification enzymes and decreased production of ROS.	ros	256-259	nuclear factor kappa B subunit 1	Homo sapiens	27-36
34951363-5	2021	Signaling pathways such as NF-kappaB, MAPKs, PI3K/Akt/ mTOR and Keap1-Nrf2-ARE modulates the detrimental effects of oxidative stress by increasing the expression of cellular antioxidant defenses, phase II detoxification enzymes and decreased production of ROS.	ros	256-259	AKT serine/threonine kinase 1	Homo sapiens	50-53
34951363-5	2021	Signaling pathways such as NF-kappaB, MAPKs, PI3K/Akt/ mTOR and Keap1-Nrf2-ARE modulates the detrimental effects of oxidative stress by increasing the expression of cellular antioxidant defenses, phase II detoxification enzymes and decreased production of ROS.	ros	256-259	mechanistic target of rapamycin kinase	Homo sapiens	55-59
34951363-5	2021	Signaling pathways such as NF-kappaB, MAPKs, PI3K/Akt/ mTOR and Keap1-Nrf2-ARE modulates the detrimental effects of oxidative stress by increasing the expression of cellular antioxidant defenses, phase II detoxification enzymes and decreased production of ROS.	ros	256-259	kelch like ECH associated protein 1	Homo sapiens	64-69
34951363-5	2021	Signaling pathways such as NF-kappaB, MAPKs, PI3K/Akt/ mTOR and Keap1-Nrf2-ARE modulates the detrimental effects of oxidative stress by increasing the expression of cellular antioxidant defenses, phase II detoxification enzymes and decreased production of ROS.	ros	256-259	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
34964128-14	2021	Moreover, knockdown of Nrf2 reversed the inhibitory effect of C3G on ROS production.	ros	69-72	NFE2 like bZIP transcription factor 2	Homo sapiens	23-27
34964128-15	2021	Summarily, C3G exerted a protective effect on ROS-mediated cellular damage in HNPCs under HG condition, which was attributed to the induction of the Nrf2/HO-1 signaling pathway.	ros	46-49	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
34939274-8	2022	Lack of FDFT1 resulted in accumulating NAT8 and D-Pantethine to lower ROS level and inhibit colon cancer cell proliferation.	ros	70-73	N-acetyltransferase 8 (putative)	Homo sapiens	39-43
34936717-7	2022	Further study showed that TRIM7 affected HIF-1alpha accumulation though targeting either the Src-triggered PI3K/AKT/mTOR signaling pathway or ROS production.	ros	142-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	41-51
34530523-10	2021	This effect may be due to the inhibition of ROS production through MAPKs, Bax, and Bcl-2 activation, and the restoration of inflammation through NF-kappaB inhibition.	ros	44-47	BCL2, apoptosis regulator	Rattus norvegicus	83-88
34987391-8	2021	Furthermore, methyl gallate inhibited the assembly of NLRP3 inflammasomes by blocking the ROS over-generation and oligomerization of NLRP3.	ros	90-93	NLR family pyrin domain containing 3	Homo sapiens	54-59
34930286-8	2021	Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	ros	37-40	interleukin 6	Homo sapiens	151-155
34930286-8	2021	Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	ros	37-40	tumor necrosis factor	Homo sapiens	161-170
34955649-14	2021	Furthermore, the increased levels of LDHA phosphorylation and the downstream NF-kappaB activation induced by LPS in epithelial cells were effectively diminished by OLFM4 overexpression and recombinant OLFM4 treatment via a reduction in ROS production and HIF1alpha expression.	ros	236-239	lactate dehydrogenase A	Homo sapiens	37-41
34955649-14	2021	Furthermore, the increased levels of LDHA phosphorylation and the downstream NF-kappaB activation induced by LPS in epithelial cells were effectively diminished by OLFM4 overexpression and recombinant OLFM4 treatment via a reduction in ROS production and HIF1alpha expression.	ros	236-239	nuclear factor kappa B subunit 1	Homo sapiens	77-86
34736964-5	2021	In addition, we found that PCS-2A effectively alleviated H2O2-induced oxidative stress via activation of the NRF2 signaling pathway, evidenced by the downregulation of ROS content and upregulation of Nrf2 expression, as well as its corresponding antioxidant enzymes.	ros	168-171	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
34710368-0	2021	Tanshinone IIA derivatives induced S-phase arrest through stabilizing c-myc G-quadruplex DNA to regulate ROS-mediated PI3K/Akt/mTOR pathway.	ros	105-108	mechanistic target of rapamycin kinase	Danio rerio	127-131
34862929-7	2021	Confirmation of osteogenic differentiation by alizarin red and detection of ROS using a Muse  Oxidative Stress Kit based on dihydroetide (DHE).	ros	76-79	KIT proto-oncogene, receptor tyrosine kinase	Equus caballus	111-114
34943041-3	2021	In this paper, we show that F. hepatica-infected mice upregulate HO-1 on peritoneal antigen-presenting cells (APC), which produce decreased levels of both reactive oxygen and nitrogen species (ROS/RNS).	ros	193-196	heme oxygenase 1	Mus musculus	65-69
34943041-6	2021	Furthermore, IL-10R neutralization as well as pharmacological treatment with the HO-1 inhibitor SnPP protected mice from parasite infection and allowed peritoneal APC to produce significantly higher ROS/RNS levels than those detected in cells from infected control mice.	ros	199-202	heme oxygenase 1	Mus musculus	81-85
34943041-7	2021	Finally, parasite infection carried out in gp91phox knockout mice with inactive NADPH oxidase was associated with decreased levels of peritoneal HO-1+ cells and splenic Tregs, and partially protected mice from the hepatic damage induced by the parasite, revealing the complexity of the molecular mechanisms involving ROS production that participate in the complex pathology induced by this helminth.	ros	317-320	heme oxygenase 1	Mus musculus	145-149
34571081-6	2021	While high levels of ROS caused activation of caspase-3 and GSDME, and induced cell pyroptosis.	ros	21-24	caspase 3	Homo sapiens	46-55
34715304-2	2021	HSCs from aged ApoE-/- mice were associated with increased ROS levels, leading to loss quiescence, DNA damage, apoptosis and telomere shortening.	ros	59-62	apolipoprotein E	Mus musculus	15-19
34927394-8	2021	Incubation with IL-4 exacerbated salivary epithelial cell senescence by increasing the expression of p16INK4A through ROS-p38 mitogen-activated protein kinase (MAPK) pathway.	ros	118-121	interleukin 4	Homo sapiens	16-20
34927394-8	2021	Incubation with IL-4 exacerbated salivary epithelial cell senescence by increasing the expression of p16INK4A through ROS-p38 mitogen-activated protein kinase (MAPK) pathway.	ros	118-121	cyclin dependent kinase inhibitor 2A	Homo sapiens	101-109
34927394-8	2021	Incubation with IL-4 exacerbated salivary epithelial cell senescence by increasing the expression of p16INK4A through ROS-p38 mitogen-activated protein kinase (MAPK) pathway.	ros	118-121	mitogen-activated protein kinase 14	Homo sapiens	122-158
34419911-5	2021	The synergistic effect between ROS and RCS promoted by the enhanced oxygen vacancies and the efficient redox recycling of FeIII/FeII and CoIII/CoII.	ros	31-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	143-147
34846489-0	2021	ROS-mediated liposomal dexamethasone: a new FA-targeted nanoformulation to combat rheumatoid arthritis via inhibiting iRhom2/TNF-alpha/BAFF pathways.	ros	0-3	rhomboid 5 homolog 2	Mus musculus	118-124
34846489-0	2021	ROS-mediated liposomal dexamethasone: a new FA-targeted nanoformulation to combat rheumatoid arthritis via inhibiting iRhom2/TNF-alpha/BAFF pathways.	ros	0-3	tumor necrosis factor	Mus musculus	125-134
34846489-8	2021	The anti-inflammatory mechanism of Dex@FA-ROS-Lips was further studied and it was found that it is possibly associated with the down-regulation of iRhom2 and the activation of the TNF-alpha/BAFF signaling pathway.	ros	42-45	rhomboid 5 homolog 2	Mus musculus	147-153
34846489-8	2021	The anti-inflammatory mechanism of Dex@FA-ROS-Lips was further studied and it was found that it is possibly associated with the down-regulation of iRhom2 and the activation of the TNF-alpha/BAFF signaling pathway.	ros	42-45	tumor necrosis factor	Mus musculus	180-189
34846489-9	2021	Therefore, the integration of nanomedicines and the RA microenvironment using multifunctional Dex@FA-ROS-Lips shall be a novel RA treatment modality with full clinical potential, and based on the enhanced therapeutic effect, the signaling pathway of iRhom2/TNF-alpha/BAFF reasonably explained the mechanism of Dex@FA-ROS-Lips in anti-RA, which suggested a molecular target for RA therapy and other inflammatory diseases.	ros	101-104	rhomboid 5 homolog 2	Mus musculus	250-256
34846489-9	2021	Therefore, the integration of nanomedicines and the RA microenvironment using multifunctional Dex@FA-ROS-Lips shall be a novel RA treatment modality with full clinical potential, and based on the enhanced therapeutic effect, the signaling pathway of iRhom2/TNF-alpha/BAFF reasonably explained the mechanism of Dex@FA-ROS-Lips in anti-RA, which suggested a molecular target for RA therapy and other inflammatory diseases.	ros	101-104	tumor necrosis factor	Mus musculus	257-266
34846489-9	2021	Therefore, the integration of nanomedicines and the RA microenvironment using multifunctional Dex@FA-ROS-Lips shall be a novel RA treatment modality with full clinical potential, and based on the enhanced therapeutic effect, the signaling pathway of iRhom2/TNF-alpha/BAFF reasonably explained the mechanism of Dex@FA-ROS-Lips in anti-RA, which suggested a molecular target for RA therapy and other inflammatory diseases.	ros	317-320	rhomboid 5 homolog 2	Mus musculus	250-256
34846489-9	2021	Therefore, the integration of nanomedicines and the RA microenvironment using multifunctional Dex@FA-ROS-Lips shall be a novel RA treatment modality with full clinical potential, and based on the enhanced therapeutic effect, the signaling pathway of iRhom2/TNF-alpha/BAFF reasonably explained the mechanism of Dex@FA-ROS-Lips in anti-RA, which suggested a molecular target for RA therapy and other inflammatory diseases.	ros	317-320	tumor necrosis factor	Mus musculus	257-266
34878954-0	2021	Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.	ros	93-96	mucolipin TRP cation channel 1	Homo sapiens	33-39
34878954-0	2021	Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.	ros	93-96	mucolipin TRP cation channel 1	Homo sapiens	40-46
34878954-0	2021	Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.	ros	93-96	tumor protein p53	Homo sapiens	104-108
34878954-0	2021	Autophagy inhibition mediated by MCOLN1/TRPML1 suppresses cancer metastasis via regulating a ROS-driven TP53/p53 pathway.	ros	93-96	tumor protein p53	Homo sapiens	109-112
34878954-2	2021	This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway.	ros	119-122	mucolipin TRP cation channel 1	Homo sapiens	61-67
34878954-2	2021	This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway.	ros	119-122	mucolipin TRP cation channel 1	Homo sapiens	68-74
34878954-2	2021	This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway.	ros	119-122	tumor protein p53	Homo sapiens	132-136
34878954-2	2021	This study demonstrates that autophagy inhibition induced by MCOLN1/TRPML1 suppresses cancer metastasis by evoking the ROS-mediated TP53/p53 pathway.	ros	119-122	tumor protein p53	Homo sapiens	137-140
34878954-4	2021	Second, our study reveals that autophagy inhibition induced by MCOLN1 leads to damaged mitochondria accumulation followed by large quantities of ROS release.	ros	145-148	mucolipin TRP cation channel 1	Homo sapiens	63-69
34878954-5	2021	Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP53 activity, which in turn modulates expression of its downstream targets which are involved in a broad spectrum of the metastatic cascade to suppress metastasis including MMP members and TWIST.	ros	40-43	tumor protein p53	Homo sapiens	102-106
34878954-5	2021	Third, we demonstrate that the elevated ROS resulting from autophagy inhibition subsequently triggers TP53 activity, which in turn modulates expression of its downstream targets which are involved in a broad spectrum of the metastatic cascade to suppress metastasis including MMP members and TWIST.	ros	40-43	twist family bHLH transcription factor 1	Homo sapiens	292-297
34878954-6	2021	In summary, our findings have established a mechanism by which autophagy inhibition suppresses metastasis via the ROS-TP53 signaling pathway.	ros	114-117	tumor protein p53	Homo sapiens	118-122
34881424-11	2022	Most importantly, addition of the Nrf2 inhibitor ML385 reversed the inhibitory effects of PA on ROS generation, proliferation, and apoptosis tolerance in hypoxia-induced PASMCs.	ros	96-99	NFE2 like bZIP transcription factor 2	Rattus norvegicus	34-38
34864826-0	2021	Targeting ERK induced cell death and p53/ROS-dependent protective autophagy in colorectal cancer.	ros	41-44	mitogen-activated protein kinase 1	Mus musculus	10-13
34864826-6	2021	But after inhibiting ROS by two kinds of ROS inhibitors NAC and SFN, the autophagy induced by CC90003 decreased, while cell death strengthened.	ros	21-24	RNA exonuclease 2	Mus musculus	64-67
34864826-6	2021	But after inhibiting ROS by two kinds of ROS inhibitors NAC and SFN, the autophagy induced by CC90003 decreased, while cell death strengthened.	ros	41-44	RNA exonuclease 2	Mus musculus	64-67
34864826-11	2021	In a word, our results demonstrated that targeting ERK leads to cell death and p53/ROS-dependent protective autophagy simultaneously in colorectal cancer, which offers new potential targets for clinical therapy.	ros	83-86	mitogen-activated protein kinase 1	Mus musculus	51-54
34508835-12	2021	CCL also induced apoptosis after eliciting ROS production and altering the membrane integrity of Leishmania infantum promastigote.	ros	43-46	crystallin gamma E, pseudogene	Homo sapiens	0-3
34688609-9	2021	Mechanistically, CPT2 functioned via suppressing the activation of Wnt/beta-catenin pathway through repressing ROS production.	ros	111-114	carnitine palmitoyltransferase 2	Mus musculus	17-21
34688609-10	2021	In conclusion, our results demonstrated that CPT2 was decreased in CRC, and CPT2 downregulation could trigger stemness and oxaliplatin resistance in CRC via activating the ROS/Wnt/beta-catenin-induced glycolytic metabolism.	ros	172-175	carnitine palmitoyltransferase 2	Mus musculus	45-49
34688609-10	2021	In conclusion, our results demonstrated that CPT2 was decreased in CRC, and CPT2 downregulation could trigger stemness and oxaliplatin resistance in CRC via activating the ROS/Wnt/beta-catenin-induced glycolytic metabolism.	ros	172-175	carnitine palmitoyltransferase 2	Mus musculus	76-80
34836795-6	2021	Subsequent studies carried out with 1-39 and 1A-38 showed that both compounds could reduce the production of ROS in the cells, probably through down-regulating NOX2 and its downstream targets, including TXNIP (thioredoxin-interacting protein) and NLRP3 (NOD-like receptor protein 3).	ros	109-112	thioredoxin interacting protein	Mus musculus	203-208
34836795-6	2021	Subsequent studies carried out with 1-39 and 1A-38 showed that both compounds could reduce the production of ROS in the cells, probably through down-regulating NOX2 and its downstream targets, including TXNIP (thioredoxin-interacting protein) and NLRP3 (NOD-like receptor protein 3).	ros	109-112	thioredoxin interacting protein	Mus musculus	210-241
34786818-8	2021	NGR1 also reduced OS-induced mitochondrial ROS and restored mitochondrial membrane potential, adenosine triphosphate production and mitochondrial DNA copy number.	ros	43-46	reticulon 4 receptor	Mus musculus	0-4
34597609-12	2021	IFN significantly prevents the neuroinflammation by decreasing the generation of ROS that reduces the activation of NLRP3/ASC/IL-1 axis thereby exerting neuroprotection as evidenced in rat model of STZ induced neuroninflammation.	ros	81-84	NLR family, pyrin domain containing 3	Rattus norvegicus	116-121
34331972-10	2021	MS analysis also showed that I/R extensively enhanced the PrSO3H of the core 1 (uqcrc1) and core 2 (uqcrc2) subunits in the matrix compartment, thus supporting the conclusion that complex III releases ROS to both sides of the inner membrane during reperfusion.	ros	201-204	ubiquinol cytochrome c reductase core protein 2	Rattus norvegicus	100-106
34637797-1	2021	AIM: This study investigated the roles of bone morphogenetic protein-4 (BMP4) and ROS in diabetic endothelial dysfunction and explored whether Salvianolic acid B (Sal B) improved endothelial function by affecting BMP4-ROS in diabetic mice.	ros	218-221	bone morphogenetic protein 4	Mus musculus	213-217
34715512-16	2021	The phytochemical significantly altered IR with enhanced glucose uptake and inhibition of ROS through JNK-AKT/mTOR signaling which may pave the way for further research in T2DM therapeutics.	ros	90-93	mitogen-activated protein kinase 8	Homo sapiens	102-105
34529240-6	2021	Here, we demonstrated that AT2R activation by CGP abrogated Ang II-induced astrocytic activation, by mitigating the ROS production, mitochondrial dysfunction, IkappaB-alpha degradation, NFkappaB nuclear translocation, and release of TNF-alpha in astrocytes.	ros	116-119	angiotensinogen	Rattus norvegicus	60-66
34529240-8	2021	Mechanistically, AT2R via protein phosphatase-2A (PP2A) abrogated the Ang II-induced NFkappaB activation, ROS generation, and subsequent astrocytic activation.	ros	106-109	angiotensinogen	Rattus norvegicus	70-76
34763093-8	2021	Moreover, metformin suppressed LL37- and TNF-alpha-induced the ROS production and MAPK-NF-kappaB signal activation in keratinocytes cells.	ros	63-66	cathelicidin antimicrobial peptide	Homo sapiens	31-35
34763093-8	2021	Moreover, metformin suppressed LL37- and TNF-alpha-induced the ROS production and MAPK-NF-kappaB signal activation in keratinocytes cells.	ros	63-66	tumor necrosis factor	Homo sapiens	41-50
34808069-10	2021	Mechanistically, CDDP alleviated HH-reinforced ROS by improving SOD and GPX1 while inhibiting pro-inflammatory cytokines and NF-kappaB expression.	ros	47-50	glutathione peroxidase 1	Rattus norvegicus	72-76
34481915-7	2021	Intrauterine administration of PACAP during the gestational period restored the endogenous antioxidant system, prevented ROS overproduction and promoted the survival of dissociated cells from animals prenatally exposed to ethanol.	ros	121-124	adenylate cyclase activating polypeptide 1	Mus musculus	31-36
34715512-16	2021	The phytochemical significantly altered IR with enhanced glucose uptake and inhibition of ROS through JNK-AKT/mTOR signaling which may pave the way for further research in T2DM therapeutics.	ros	90-93	AKT serine/threonine kinase 1	Rattus norvegicus	106-109
34715512-16	2021	The phytochemical significantly altered IR with enhanced glucose uptake and inhibition of ROS through JNK-AKT/mTOR signaling which may pave the way for further research in T2DM therapeutics.	ros	90-93	mechanistic target of rapamycin kinase	Homo sapiens	110-114
34196914-2	2021	Phosphatidylinositol 4-kinase III (PI4KB), which is required by enteroviruses for RO formation, yields phosphatidylinositol-4-phosphate (PI4P) on ROs.	ros	146-149	phosphatidylinositol 4-kinase beta	Homo sapiens	35-40
34225572-5	2021	Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway.	ros	88-91	mechanistic target of rapamycin kinase	Homo sapiens	184-213
34225572-5	2021	Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway.	ros	88-91	mechanistic target of rapamycin kinase	Homo sapiens	215-219
34225572-5	2021	Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway.	ros	88-91	NFE2 like bZIP transcription factor 2	Homo sapiens	233-266
34844627-11	2021	In contrast, BKM120 prevented the elimination of ROS by inactivation of NRF2, leading to accumulation of DNA damage.	ros	49-52	nuclear factor, erythroid derived 2, like 2	Mus musculus	72-76
34845191-9	2021	Reconstitution of MICU3 enhanced antioxidants, prevented the accumulation of mitochondrial ROS, decreased apoptosis, and increased myogenesis.	ros	91-94	mitochondrial calcium uptake family, member 3	Mus musculus	18-23
34815381-8	2021	Finally, we demonstrated that HACE1 dramatically reduced cellular ROS levels by activating NRF2, thereby decreasing the response of glioma cells to radiation.	ros	66-69	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
34940569-5	2021	Mechanistically, l-THP promotes the autophagic response by activating the AMPK-mTOR-ULK1 and the ROS-JNK-ATG cascades and impairing the ERK/AKT signaling.	ros	97-100	mitogen-activated protein kinase 8	Homo sapiens	101-104
34873574-10	2021	APOE and CTSD genes were mainly enriched in the regulation of ROS and oxidative stress.	ros	62-65	apolipoprotein E	Homo sapiens	0-4
34843004-9	2021	In SH-SY5Y cells, FOXO3 overexpression increased, whereas FOXO3 knockdown reduced the cell apoptosis and ROS levels.	ros	105-108	forkhead box O3	Homo sapiens	58-63
34653407-6	2021	We found that AZD2461 reduced cell proliferation in wtp53 and p53-/- cancer cells by increasing ROS and DNA damage, while R273H mutant (mut) p53 counteracted these effects.	ros	96-99	tumor protein p53	Homo sapiens	62-65
34787893-7	2021	Knockdown of S100A10 effectively counteracted TNF-alpha-induced ROS level, apoptosis, and calcium level and associated with decreased inflammation-related metalloproteinase 1 (MMP1), MMP13, and nuclear necrosis factor-kappa B (NF-kappaB)-p65 and increased survivin and cytoplasmic NF-kappaB-p65.	ros	64-67	S100 calcium binding protein A10	Homo sapiens	13-20
34787893-7	2021	Knockdown of S100A10 effectively counteracted TNF-alpha-induced ROS level, apoptosis, and calcium level and associated with decreased inflammation-related metalloproteinase 1 (MMP1), MMP13, and nuclear necrosis factor-kappa B (NF-kappaB)-p65 and increased survivin and cytoplasmic NF-kappaB-p65.	ros	64-67	tumor necrosis factor	Homo sapiens	46-55
34829685-6	2021	In neurons NMDA induced overproduction of ROS, in astrocytes TNF-alpha initiated ROS generation, NADPH oxidase activation, and phosphorylation of ERK1/2.	ros	81-84	tumor necrosis factor	Rattus norvegicus	61-70
34814838-7	2021	The transcriptional levels of ABA-responsive genes and genes encoding ROS-quenching enzymes were lower in pdi-AtPDI1m1 and pdi-AtPDI1m2 than in pdi-AtPDI1.	ros	70-73	PDI-like 1-3	Arabidopsis thaliana	148-154
34834392-9	2021	Moreover, ZnONPs also enhanced ROS production which led to a significant loss of mitochondrial membrane potential and activated caspase-3 gene expression and caspase-3/7 activity in human hepatocellular carcinoma (HepG2) cells.	ros	31-34	caspase 3	Homo sapiens	128-137
34834392-9	2021	Moreover, ZnONPs also enhanced ROS production which led to a significant loss of mitochondrial membrane potential and activated caspase-3 gene expression and caspase-3/7 activity in human hepatocellular carcinoma (HepG2) cells.	ros	31-34	caspase 3	Homo sapiens	158-169
34789190-3	2021	beta-lap undergoes NQO1-dependent futile redox cycling, generating massive ROS and oxidative DNA lesions, leading to cell death.	ros	75-78	NAD(P)H quinone dehydrogenase 1	Homo sapiens	19-23
34363387-6	2021	In MA-10 cells in which Sirt1 or Nrf2 were suppressed by nicotinamide (NAM) or ML385, respectively, or in which siRNAs were used for knockdown of Sirt1 or Nrf2, increased ROS levels and decreased progesterone production occurred.	ros	171-174	nuclear factor, erythroid derived 2, like 2	Mus musculus	33-37
34363387-6	2021	In MA-10 cells in which Sirt1 or Nrf2 were suppressed by nicotinamide (NAM) or ML385, respectively, or in which siRNAs were used for knockdown of Sirt1 or Nrf2, increased ROS levels and decreased progesterone production occurred.	ros	171-174	nuclear factor, erythroid derived 2, like 2	Mus musculus	155-159
34407971-8	2021	NRF2-enriched HNSCC samples from the Cancer Genome Atlas with enrichment in OXPHOS, fatty acid metabolism, Myc, Mtor, ROS, and glycolytic signaling networks exhibited worse survival.	ros	118-121	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34407971-11	2021	Mechanistically, NRF2 drives ROS and mitochondrial respiration, and NRF2 is a critical regulator of redox homeostasis that can be crippled by disruption of OXPHOS.	ros	29-32	nuclear factor, erythroid derived 2, like 2	Mus musculus	17-21
34868022-5	2021	AhR regulation of Muc5ac expression, mitochondrial ROS (Mito-ROS) generation, and NLRP3 inflammasome was determined by AhR knockdown, the antagonist CH223191, and AhR-/- mice.	ros	61-64	aryl-hydrocarbon receptor	Mus musculus	0-3
34801863-0	2021	A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy.	ros	37-40	kelch like ECH associated protein 1	Homo sapiens	16-21
34868022-11	2021	Furthermore, AhR deletion in HBECs led to enhanced ROS generation, particularly Mito-ROS, and inhibition of ROS or Mito-ROS subsequently suppressed the inflammasome activation.	ros	51-54	aryl-hydrocarbon receptor	Mus musculus	13-16
34868022-11	2021	Furthermore, AhR deletion in HBECs led to enhanced ROS generation, particularly Mito-ROS, and inhibition of ROS or Mito-ROS subsequently suppressed the inflammasome activation.	ros	108-111	aryl-hydrocarbon receptor	Mus musculus	13-16
34787291-11	2021	Furthermore, the APS could activate the AMPK signaling pathway, enhance the autophagy and suppress the production of ROS.	ros	117-120	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	40-44
34867815-3	2021	Growing evidence suggest the up-regulated XO avtivity and increased production of free oxygen radical (ROS) correspondingly are the core pathogenesis of HF with hyperuricemia, which results in a whole cluster of pathophysiologic cardiovascular effects such as oxidative stress, endothelial dysfunction, vascular inflammation, left ventricular (LV) dysfunction as well as insulin resistance (IR).	ros	103-106	insulin	Homo sapiens	371-378
34868022-0	2021	Epithelial Aryl Hydrocarbon Receptor Protects From Mucus Production by Inhibiting ROS-Triggered NLRP3 Inflammasome in Asthma.	ros	82-85	aryl-hydrocarbon receptor	Mus musculus	11-36
34868022-5	2021	AhR regulation of Muc5ac expression, mitochondrial ROS (Mito-ROS) generation, and NLRP3 inflammasome was determined by AhR knockdown, the antagonist CH223191, and AhR-/- mice.	ros	51-54	aryl-hydrocarbon receptor	Mus musculus	0-3
34520770-0	2021	TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner.	ros	18-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	44-48
34520770-0	2021	TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner.	ros	18-21	cadherin 1	Homo sapiens	86-96
34520770-4	2021	Inhibition of HER2 or EphB4 is discovered to induce ROS-dependent apoptosis by decreasing E-cadherin expression in SKBR3 and MDA-MB-453 cells.	ros	52-55	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-18
34520770-4	2021	Inhibition of HER2 or EphB4 is discovered to induce ROS-dependent apoptosis by decreasing E-cadherin expression in SKBR3 and MDA-MB-453 cells.	ros	52-55	cadherin 1	Homo sapiens	90-100
34520770-6	2021	Mechanistic investigation revealed that TAD blockades both EphB4 positive signal transduction and activation of HER2 signal transduction, thereby suppressing E-cadherin/TGF-beta/p-Smad2/3 signaling axis to elicit ROS-dependent endogenous mitochondrial apoptosis.	ros	213-216	cadherin 1	Homo sapiens	158-168
34520770-7	2021	Together, these findings not only provide a new approach for HER2-BC therapy but also increase our understanding of the regulating effect of E-cadherin by HER2 and EphB4 in ROS-mediated apoptosis.	ros	173-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	61-65
34520770-7	2021	Together, these findings not only provide a new approach for HER2-BC therapy but also increase our understanding of the regulating effect of E-cadherin by HER2 and EphB4 in ROS-mediated apoptosis.	ros	173-176	cadherin 1	Homo sapiens	141-151
34520770-7	2021	Together, these findings not only provide a new approach for HER2-BC therapy but also increase our understanding of the regulating effect of E-cadherin by HER2 and EphB4 in ROS-mediated apoptosis.	ros	173-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	155-159
34801863-6	2021	We also demonstrate that inhibitors of the KEAP1-PGAM5 protein-protein interaction (including CPUY192018) mimic the effect of mitochondrial ROS and sensitize mitophagy machinery, suggesting that these inhibitors could be used as pharmacological regulators of mitophagy.	ros	140-143	kelch like ECH associated protein 1	Homo sapiens	43-48
34758851-7	2021	The increased activation of Nrf2 and its target antioxidant genes by curcumin could significantly decrease As3+-generated ROS.	ros	122-125	NFE2 like bZIP transcription factor 2	Homo sapiens	28-32
34509082-11	2021	Inflammatory response, cellular total and mitochondrial ROS production, and Drp1 expression levels in aorta tissues were also dramatically ameliorated in HFD-fed ApoE-/- mice, contributing to the inhibition of atherosclerosis in vivo.	ros	56-59	apolipoprotein E	Mus musculus	162-166
34758851-9	2021	Knockdown of Nrf2 abolished curcumin-induced autophagy and downregulated ROS.	ros	73-76	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
34758851-13	2021	Overexpression of Nrf2 in AsT demonstrated that curcumin increased ROS levels and induced cell apoptosis via the downregulation of Nrf2.	ros	67-70	solute carrier family 17 member 5	Homo sapiens	26-29
34763297-7	2021	Mechanistic investigations using bone marrow cells and RAW 264.7 cells revealed that deficiency of Nfe2l1 leads to accelerated and elevated OD, which is attributed, at least in part, to enhanced accumulation of ROS in the early stage of OD and expression of nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1alpha (Nfatc1/alpha).	ros	211-214	nuclear factor, erythroid derived 2,-like 1	Mus musculus	99-105
34739306-5	2022	Simultaneously, they can reset the levels of pro-apoptotic proteins that belong to the Bcl-2 and caspase family and decrease the intracellular levels of ROS and pro-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6.	ros	153-156	tumor necrosis factor	Homo sapiens	197-206
34819853-6	2021	Moreover, the LHD suppressed ROS fluorescence expression by inhibiting MDA expression and increasing SOD activity.	ros	29-32	superoxide dismutase 1	Homo sapiens	101-104
34339726-2	2021	The viability was assessed after treatment with palladium (II) complex (1.56-100 muM) and thalidomide (0.1-400 muM) alone by using ATP assay for 48 h. Palladium (II) complex was found to inhibit growth statistically significant in a dose-dependent manner in HUVECs and promoted PARP-1 cleavage through the production of ROS.	ros	320-323	poly(ADP-ribose) polymerase 1	Homo sapiens	278-284
34790121-6	2021	It is thought that HER2-targeting drugs inhibit HER2/NRG 1 dimer formation, causing an increase in ROS in the mitochondria of cardiomyocytes and inhibiting the PI3K/Akt and Ras/MAPK pathways, resulting in cell apoptosis.	ros	99-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	19-23
34790121-6	2021	It is thought that HER2-targeting drugs inhibit HER2/NRG 1 dimer formation, causing an increase in ROS in the mitochondria of cardiomyocytes and inhibiting the PI3K/Akt and Ras/MAPK pathways, resulting in cell apoptosis.	ros	99-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	48-52
34173812-8	2021	Fisetin could also ameliorate and reduce oxLDL-induced upregulation of SREBP-1 and thereby expression of its downstream liposynthesis genes HMGCR and FAS via inhibiting ROS-induced NLRP3 activation.	ros	169-172	NLR family pyrin domain containing 3	Homo sapiens	181-186
34478836-10	2021	We observed that Abeta monomers significantly improved the antioxidant capacity (the GSH level, SOD activity and total antioxidant capacity) and decreased the oxidative stress (the ROS and MDA levels) of LECs, while CDC25B knockdown decreased the antioxidant effects of Abeta, disrupting redox homeostasis.	ros	181-184	amyloid beta precursor protein	Homo sapiens	17-22
34446542-9	2021	Implications: This study reveals that blocking p27 tyrosine phosphorylation inhibits CDK4 and CDK2 activity and induces ROS-dependent necroptosis, suggesting a novel therapeutic option for endocrine and CDK4 inhibitor-resistant HR+ tumors.	ros	120-123	dynactin subunit 6	Homo sapiens	47-50
34238903-0	2021	FUNDC1 Regulates Autophagy by Inhibiting ROS-NLRP3 Signaling to Avoid Apoptosis in the Lung In A Lipopolysaccharide-Induced Mouse Model.	ros	41-44	FUN14 domain containing 1	Mus musculus	0-6
34482221-0	2021	Pristimerin induces apoptosis and tumor inhibition of oral squamous cell carcinoma through activating ROS-dependent ER stress/Noxa pathway.	ros	102-105	phorbol-12-myristate-13-acetate-induced protein 1	Homo sapiens	126-130
34238903-4	2021	This study explored whether FUNDC1 regulates autophagy by inhibiting ROS-NLRP3 signaling to avoid apoptosis in the lung in a lipopolysaccharide-induced mouse model.	ros	69-72	FUN14 domain containing 1	Mus musculus	28-34
34708887-8	2022	In summary, PM2.5 -induced NOX up-regulation is the source of ROS in EA.hy926, which activated AKT/eNOS/NO signal response leading to endothelial dysfunction and inflammatory damage in EA.hy926 cells.	ros	62-65	AKT serine/threonine kinase 1	Homo sapiens	95-98
34311033-7	2021	Furthermore, we confirmed the role of TRPC3 and the ROCE-AKT/GSK3beta-CNB2/NFATc2 signaling cascade in regulating cell cycle checkpoint, apoptosis cascade, and intracellular ROS production in GC.	ros	174-177	AKT serine/threonine kinase 1	Homo sapiens	57-60
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	ros	275-278	tumor protein p53	Homo sapiens	29-32
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	ros	275-278	tumor protein p53	Homo sapiens	49-52
34708887-8	2022	In summary, PM2.5 -induced NOX up-regulation is the source of ROS in EA.hy926, which activated AKT/eNOS/NO signal response leading to endothelial dysfunction and inflammatory damage in EA.hy926 cells.	ros	62-65	nitric oxide synthase 3	Homo sapiens	99-103
34549762-6	2021	Consequently, the activation of the lipopolysaccharide (LPS) translocation-mediated TLR4 pathway and the subsequent inflammatory response and ROS overproduction in the liver were suppressed.	ros	142-145	toll-like receptor 4	Mus musculus	84-88
34769076-9	2021	Angiogenic dysfunction in Sephs1-knockout cells is mediated by a reduction in nitric oxide and an increase in ROS.	ros	110-113	selenophosphate synthetase 1	Mus musculus	26-32
34832853-6	2021	Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA-AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFkappaB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells.	ros	60-63	mitogen-activated protein kinase 1	Homo sapiens	145-148
34832853-6	2021	Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA-AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFkappaB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells.	ros	60-63	nuclear factor kappa B subunit 1	Homo sapiens	222-230
34745132-9	2021	TLR4-lacking neutrophils showed a higher phagocytic activity in the basal state, they were preferentially engulfed by the microglia after stroke, and they produced less radical oxygen species (ROS) in the first stage of the inflammatory process.	ros	193-196	toll-like receptor 4	Mus musculus	0-4
34671066-5	2021	Overexpressing mitochondrial-targeted catalase (mCAT) using adeno-associated virus reduces mitochondrial ROS, oxidative damage, ameliorates the progression of PKD and partially restores expression of proteins involved in FAO and the TCA cycle.	ros	105-108	catalase	Mus musculus	48-52
34671066-6	2021	In human ADPKD cells, inducing mitochondrial ROS increased ERK1/2 phosphorylation and decreased AMPK phosphorylation, whereas the converse was observed with increased scavenging of ROS in the mitochondria.	ros	45-48	mitogen-activated protein kinase 3	Homo sapiens	59-65
34515716-7	2021	KRQKYD could inhibit the production of ROS by upregulating the expression of the NRF2/HO-1 antioxidant defense system and by reducing oxidative stress injury in liver cells.	ros	39-42	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
34515716-7	2021	KRQKYD could inhibit the production of ROS by upregulating the expression of the NRF2/HO-1 antioxidant defense system and by reducing oxidative stress injury in liver cells.	ros	39-42	heme oxygenase 1	Mus musculus	86-90
34687223-7	2022	Moreover, pretreatment of 5 mM ROS scavenger N-acetyl-L-cysteine (NAC) ameliorated PFOS-induced NLRP3 inflammasome activation and pyroptosis.	ros	31-34	NLR family, pyrin domain containing 3	Rattus norvegicus	96-101
34755672-9	2021	Chrysin treatment significantly reduced the generation of endogenous ROS, and treatment with N-Acetyl-L-cysteine to eliminate intracellular ROS obviously reduced the expressions of iNOS and COX-2 (P < 0.05) and blocked the AKT/mTOR pathway (P < 0.05).	ros	140-143	nitric oxide synthase 2, inducible	Mus musculus	181-185
34755672-9	2021	Chrysin treatment significantly reduced the generation of endogenous ROS, and treatment with N-Acetyl-L-cysteine to eliminate intracellular ROS obviously reduced the expressions of iNOS and COX-2 (P < 0.05) and blocked the AKT/mTOR pathway (P < 0.05).	ros	140-143	thymoma viral proto-oncogene 1	Mus musculus	223-226
34755672-10	2021	CONCLUSION: Chrysin can inhibit the synthesis of the upstream signaling molecule ROS to inhibit the activation of AKT/mTOR signaling pathway, regulate the translation process of ribosomes, down-regulate the synthesis and release of pro-inflammatory cytokines and inflammatory mediators, and thus produce anti-inflammatory effects.	ros	81-84	thymoma viral proto-oncogene 1	Mus musculus	114-117
34681952-11	2021	In the case of anti-cancerous activities, the lowest viability (23.45 +- 1.40%) with enhanced ROS/NOS production led to a significant disruption of mitochondrial membrane potential and greater caspase-3/7 gene expression and activity by UV-C mediated bimetallic Ag-ZnONPs (0.1/0.5).	ros	94-97	caspase 3	Homo sapiens	193-204
34652584-5	2022	Then the elevated level of ROS activated the inflammatory response mediated by NLRP3 inflammasome (NLRP3, ASC, caspase-1).	ros	27-30	NLR family, pyrin domain containing 3	Rattus norvegicus	79-84
34681895-5	2021	Meanwhile, the literature reviewed the alternative or method against OTA toxicity by reducing ROS production, oxidative stress, activating the Nrf2 pathway, through using nanoparticles, a natural flavonoid, and metal supplement.	ros	94-97	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
34652584-5	2022	Then the elevated level of ROS activated the inflammatory response mediated by NLRP3 inflammasome (NLRP3, ASC, caspase-1).	ros	27-30	NLR family, pyrin domain containing 3	Rattus norvegicus	99-104
34652584-10	2022	CONCLUSION: Astaxanthin can protect the kidney in CI-AKI by inhibiting the activation of NLRP3 inflammasome-IL-1beta/IL-18 through inhibition of the production of ROS.	ros	163-166	NLR family, pyrin domain containing 3	Rattus norvegicus	89-94
34652584-10	2022	CONCLUSION: Astaxanthin can protect the kidney in CI-AKI by inhibiting the activation of NLRP3 inflammasome-IL-1beta/IL-18 through inhibition of the production of ROS.	ros	163-166	interleukin 1 alpha	Rattus norvegicus	108-116
34681736-5	2021	ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria.	ros	0-3	DNA damage inducible transcript 3	Homo sapiens	77-81
34390950-7	2021	Moreover, artificially decreasing Arhgef3 expression remarkedly reduced ROS generation after LPS treatment.	ros	72-75	Rho guanine nucleotide exchange factor (GEF) 3	Mus musculus	34-41
34681736-5	2021	ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	115-136
34681736-5	2021	ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	138-141
34681736-5	2021	ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria.	ros	0-3	BCL2 apoptosis regulator	Homo sapiens	171-175
34681736-5	2021	ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria.	ros	0-3	cytochrome c, somatic	Homo sapiens	195-207
34680207-3	2021	By integrating metabolomics and transcriptomics in a triple-negative human breast cancer cell line, we show that genetic and pharmacological down-regulation of CtBP2 strongly reduces cell proliferation by modulating the redox balance, nucleotide synthesis, ROS generation, and scavenging.	ros	257-260	C-terminal binding protein 2	Homo sapiens	160-165
34650122-9	2021	In the knockdown BNIP3 group, p62 was overexpressed, ROS accumulated and the apoptotic process was elevated under oxidative stress condition.	ros	53-56	BCL2 interacting protein 3	Homo sapiens	17-22
34645930-4	2021	Also, the outcomes revealed an improvement in the CCl4-induced liver, lung, brain, and spleen toxicity by reducing the levels of ROS, lipid peroxidation, NO, and the gene expression of NF-kappaB and its relevant ROS-mediated inflammatory genes.	ros	129-132	C-C motif chemokine ligand 4	Rattus norvegicus	50-54
34645930-4	2021	Also, the outcomes revealed an improvement in the CCl4-induced liver, lung, brain, and spleen toxicity by reducing the levels of ROS, lipid peroxidation, NO, and the gene expression of NF-kappaB and its relevant ROS-mediated inflammatory genes.	ros	212-215	C-C motif chemokine ligand 4	Rattus norvegicus	50-54
34645930-7	2021	Therefore, ASE can ameliorate the systemic toxicity caused by CCl4 via regulation of the ROS/NF-kappaB signaling pathway in the rat organs, which is owed to its phytochemical composition.	ros	89-92	C-C motif chemokine ligand 4	Rattus norvegicus	62-66
34692691-0	2021	TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells.	ros	40-43	mechanistic target of rapamycin kinase	Homo sapiens	67-71
34384953-11	2021	CONCLUSIONS: AZD8055 ameliorated EAE through anti-inflammatory and anti-pyroptosis effects via the mammalian target of mTOR/ROS/NLRP3 pathway.	ros	124-127	mechanistic target of rapamycin kinase	Homo sapiens	119-123
34384953-11	2021	CONCLUSIONS: AZD8055 ameliorated EAE through anti-inflammatory and anti-pyroptosis effects via the mammalian target of mTOR/ROS/NLRP3 pathway.	ros	124-127	NLR family pyrin domain containing 3	Homo sapiens	128-133
34692691-8	2021	Notably, our further experiments showed that TEOA induced autophagic cell death in pancreatic ductal adenocarcinoma cells by inactivating the ROS-dependent mTOR/p70S6k signaling pathway.	ros	142-145	mechanistic target of rapamycin kinase	Homo sapiens	156-160
34692691-10	2021	Concomitantly, N-acetylcysteine, a ROS scavenger, abolished the inhibition of the mTOR signaling pathway, thus preventing autophagy and restoring cell viability.	ros	35-38	mechanistic target of rapamycin kinase	Homo sapiens	82-86
34626114-7	2022	Metformin also exhibited antioxidant effects, as it reduced ROS production which is associated with the upregulation of FoxO3a and PGC-1alpha in gut of 6-month-old fish with poly I:C-injection.	ros	60-63	forkhead box O3	Homo sapiens	120-126
34626114-7	2022	Metformin also exhibited antioxidant effects, as it reduced ROS production which is associated with the upregulation of FoxO3a and PGC-1alpha in gut of 6-month-old fish with poly I:C-injection.	ros	60-63	PPARG coactivator 1 alpha	Homo sapiens	131-141
34468815-8	2021	Nox4 was significantly upregulated only in CMD-exposed ABCs and NOX4 activation of PI3K/AKT can lead to increased ROS levels in human cancer cells.	ros	114-117	AKT serine/threonine kinase 1	Homo sapiens	88-91
34339807-8	2021	GENERAL SIGNIFICANCE: The experimental findings acquired in the current study could help to elucidate the consequences of oxidative stress in vivo on damage to the structure of fibrinogen/fibrin under the action of different ROS species.	ros	225-228	fibrinogen beta chain	Homo sapiens	177-187
34217821-0	2021	The protein-bound uremic toxin p-cresyl-sulfate promotes intracellular ROS production and lipid peroxidation in 3T3-L1 adipose cells.	ros	71-74	PCS	Homo sapiens	31-47
34217821-3	2021	This study was designed to decipher whether the protein bound uremic toxin p-cresyl-sulfate (p-CS) could contribute to ROS production in WAT and promote oxidative stress.	ros	119-122	PCS	Homo sapiens	75-91
34289205-5	2021	We also tested 16 other structural derivatives of ALT and found that natural ALT was the most efficient at increasing ROS-induced LATS kinase activities and thus YAP1/TAZ phosphorylation.	ros	118-121	tafazzin, phospholipid-lysophospholipid transacylase	Mus musculus	167-170
34426255-3	2021	The activity of ACE in rat aorta segments was determined by measuring the hydrolysis of hippuryl-L-histidyl-L-leucine, and the production of ROS was estimated from the oxidation of dichlorodihydrofluorescein.	ros	141-144	angiotensin I converting enzyme	Rattus norvegicus	16-19
34387860-4	2021	Upon NLRP3 activation, AKT activity is inhibited by second stimulus-induced ROS.	ros	76-79	NLR family pyrin domain containing 3	Homo sapiens	5-10
34175740-10	2021	Taken together, novel ultrasmall mesoporous Ce-BGn showed remarkable catalase-mimic activity via surface containing Ce3+/Ce4+ ions which can scavenge ROS (Ce3+  Ce4+) and decompose H2O2 molecules into H2O and O2.	ros	150-153	biglycan	Homo sapiens	47-50
34363947-4	2021	Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells.	ros	155-158	interleukin 1 alpha	Rattus norvegicus	23-31
34387860-4	2021	Upon NLRP3 activation, AKT activity is inhibited by second stimulus-induced ROS.	ros	76-79	AKT serine/threonine kinase 1	Homo sapiens	23-26
34363947-4	2021	Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells.	ros	155-158	tumor necrosis factor	Rattus norvegicus	33-42
34363947-4	2021	Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells.	ros	155-158	aquaporin 8	Rattus norvegicus	67-71
34658913-5	2021	Nrf2 has a crucial protective role against these ROS.	ros	49-52	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
34363947-4	2021	Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells.	ros	155-158	aquaporin 8	Rattus norvegicus	336-340
34478853-13	2021	The results indicated that prenatal toxic factor hypoxia resulted in abnormal ETBR activation, which enhanced ET-1-mediated vasoconstriction of pulmonary arteries and pulmonary artery smooth muscle cell proliferation through ETBR/Nox1/4-derived ROS pathway.	ros	245-248	endothelin 1	Rattus norvegicus	110-114
34479089-6	2021	Mechanistically, DOX stimulation led to excessive accumulation of ROS, which activated the NF-kappaB-Snail pathway and resulted in EndMT.	ros	66-69	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	91-100
34403740-11	2021	Moreover, insufficient expression of Bax/Bak counteracted hypoxia-mediated downregulation of mitochondrial function, thereby adding to DHA-induced ROS production and lipid peroxidation in hypoxia.	ros	147-150	BCL2 associated X, apoptosis regulator	Homo sapiens	37-40
34314760-0	2021	Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway.	ros	94-97	NFE2 like bZIP transcription factor 2	Rattus norvegicus	83-87
34314760-10	2021	In conclusion, ghrelin ameliorates post-MI and Ang II-induced cardiac fibrosis by activating Nrf2, which in turn inhibits the NADPH/ROS pathway.	ros	132-135	NFE2 like bZIP transcription factor 2	Rattus norvegicus	93-97
34580807-0	2021	Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation.	ros	71-74	mitogen-activated protein kinase 1	Homo sapiens	84-87
34638797-0	2021	Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-kappaB Signaling in MDA-MB-231 Cells.	ros	70-73	signal transducer and activator of transcription 3	Homo sapiens	97-102
34580807-7	2021	In the latter condition, serum and glucose deprivation triggered autophagy via a transient phosphorylation of ERK1/2, whereas Cd-modified autophagy via a ROS-dependent sustained activation of ERK1/2.	ros	154-157	mitogen-activated protein kinase 3	Homo sapiens	192-198
34638797-0	2021	Ginsenoside Rh1 Prevents Migration and Invasion through Mitochondrial ROS-Mediated Inhibition of STAT3/NF-kappaB Signaling in MDA-MB-231 Cells.	ros	70-73	nuclear factor kappa B subunit 1	Homo sapiens	103-112
34691420-4	2021	Transforming growth factor beta-1 (TGF-beta1) plays a role in increasing the production of ROS, thus, when the concentration is low, it would lead to an improvement in physical fitness.	ros	91-94	transforming growth factor beta 1	Homo sapiens	0-33
34559194-10	2021	Despite enhanced ROS levels within the local inflammatory milieu, JIA T cells are hyperproliferative and reveal an overexpression of miR-23a, which is an inhibitor of PPIF, the regulator of mitochondrial ROS escape.	ros	204-207	peptidylprolyl isomerase F	Homo sapiens	167-171
34583974-0	2021	SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells.	ros	30-33	CD4 molecule	Homo sapiens	71-74
34583974-6	2021	Ectopic TFAM expression increases mitochondrial mass and mitochondrial ROS production and rescues defects in the antigen-specific response in the SATB1-deficient T cells.	ros	71-74	transcription factor A, mitochondrial	Homo sapiens	8-12
34691420-4	2021	Transforming growth factor beta-1 (TGF-beta1) plays a role in increasing the production of ROS, thus, when the concentration is low, it would lead to an improvement in physical fitness.	ros	91-94	transforming growth factor beta 1	Homo sapiens	35-44
34489530-6	2021	Deletion of SDHD (Succinate dehydrogenase) gene from the complex II in the Substantia Nigra of Thy1-C/EBPbeta mice triggers ROS and PD pathologies, resulting in motor disorders.	ros	124-127	thymus cell antigen 1, theta	Mus musculus	95-99
34584694-0	2021	Supranutritional selenium suppresses ROS-induced generation of RANKL-expressing osteoclastogenic CD4+ T cells and ameliorates rheumatoid arthritis.	ros	37-40	CD4 molecule	Homo sapiens	97-100
34274415-6	2021	Our results demonstrated that cisplatin concurrently induced apoptosis and autophagy in OSCC cell lines partially through the ROS/JNK pathway.	ros	126-129	mitogen-activated protein kinase 8	Homo sapiens	130-133
34573083-1	2021	In the case of various pathologies, an imbalance between ROS generation and the endogenous AOS can be observed, which leads to excessive ROS accumulation, intensification of LPO processes, and oxidative stress.	ros	57-60	lactoperoxidase	Homo sapiens	174-177
34646383-10	2021	The deletion of PDK1 in Treg cells destroyed the iron ion balance through regulating MEK-ERK signaling and CD71 expression, resulting in excessive production of intracellular ROS, which did not depend on the down-regulation of mTORC1 signaling.	ros	175-178	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	16-20
34646383-11	2021	Inhibition of excessive ROS, activated MEK-Erk signaling or overload Fe2+ could partially rescue the survival of PDK1-deficient Treg cells.	ros	24-27	mitogen-activated protein kinase 1	Mus musculus	43-46
34646383-11	2021	Inhibition of excessive ROS, activated MEK-Erk signaling or overload Fe2+ could partially rescue the survival of PDK1-deficient Treg cells.	ros	24-27	pyruvate dehydrogenase kinase, isoenzyme 1	Mus musculus	113-117
34616396-4	2021	We observed an increase in apoptosis, ROS generation, MCP-1, and intracellular calcium expression in the THP-1 macrophages.	ros	38-41	GLI family zinc finger 2	Homo sapiens	105-110
34616396-11	2021	The S protein stimulation induced ROS generation and changed the mitogenic responses of the PBMCs through the upregulation of TNFalpha and interleukin (IL)-17 cytokine expression.	ros	34-37	tumor necrosis factor	Homo sapiens	126-134
34530866-0	2021	NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1alpha pathway.	ros	115-118	sirtuin 1	Rattus norvegicus	179-184
34530866-0	2021	NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1alpha pathway.	ros	115-118	PPARG coactivator 1 alpha	Rattus norvegicus	185-195
34530866-11	2021	In vitro study confirmed that NAD+ administration had protective effects on hypoxia-induced neuroinflammation and mitochondrial damage, as well as ROS production in BV2 microglia via Sirt1/PGC-1alpha pathway.	ros	147-150	sirtuin 1	Rattus norvegicus	183-188
34530866-11	2021	In vitro study confirmed that NAD+ administration had protective effects on hypoxia-induced neuroinflammation and mitochondrial damage, as well as ROS production in BV2 microglia via Sirt1/PGC-1alpha pathway.	ros	147-150	PPARG coactivator 1 alpha	Rattus norvegicus	189-199
34530866-13	2021	CONCLUSIONS: NAD+ ameliorated cognitive impairment and dampened neuroinflammation in CCH models in vivo and in vitro, and these beneficial effects were associated with mitochondrial protection and ROS inhibition via activating Sirt1/PGC-1alpha pathway.	ros	197-200	sirtuin 1	Rattus norvegicus	227-232
34510030-4	2021	These effects reflected caspase 3-mediated apoptosis and could be attenuated or abolished by inhibiting ROS production with N-acetyl-L-cysteine, inhibiting autophagy with chloroquine, or silencing ATG7 with targeted siRNA.	ros	104-107	caspase 3	Homo sapiens	24-33
34508588-3	2022	Here we show that constitutive plasma membrane translocation and activation of the GLUT4 glucose transporter, via ROS-dependent AMPKalpha and p38 hyperactivation, occurs in CS, resulting in accelerated glycolysis, and increased fatty acid synthesis and storage as lipid droplets in primary fibroblasts.	ros	114-117	mitogen-activated protein kinase 14	Homo sapiens	142-145
34225164-6	2021	Among these compounds, the optimally active compound sAc15 elicited a potent protective effect on cell growth of PC12 cells by effectively eliminating ROS generation in response to oxidative stress injury by activating the Nrf2/HO-1 antioxidant signaling pathway.	ros	151-154	NFE2 like bZIP transcription factor 2	Rattus norvegicus	223-227
34527170-8	2021	In vitro, OST could inhibit TGF-beta1-induced Smad3 phosphorylation, differentiation, proliferation, collagen synthesis, NOX4 expression, and ROS generation in human lung fibroblasts in a concentration-dependent manner.	ros	142-145	transforming growth factor beta 1	Homo sapiens	28-37
34926792-4	2021	In this study, targeted self-assembled peptide amphiphile (PA) nanofibers were developed that cleave in response to biochemical cues expressed in atherosclerotic lesions-reactive oxygen species (ROS) and intracellular glutathione-to deliver a liver X receptor agonist (LXR) to enhance macrophage cholesterol efflux.	ros	195-198	nuclear receptor subfamily 1, group H, member 3	Mus musculus	243-267
34926792-4	2021	In this study, targeted self-assembled peptide amphiphile (PA) nanofibers were developed that cleave in response to biochemical cues expressed in atherosclerotic lesions-reactive oxygen species (ROS) and intracellular glutathione-to deliver a liver X receptor agonist (LXR) to enhance macrophage cholesterol efflux.	ros	195-198	nuclear receptor subfamily 1, group H, member 3	Mus musculus	269-272
34926792-5	2021	The PAs released LXR in response to physiological levels of ROS and reducing agents and could be co-assembled with plaque-targeting PAs to form nanofibers.	ros	60-63	nuclear receptor subfamily 1, group H, member 3	Mus musculus	17-20
34130124-13	2021	It was further found that shRNA-mediated Prdx4 knockdown exacerbated PA-induced oxidative stress and cardiomyocyte apoptosis, whereas overexpressing Prdx4 in the H9c2 cells noteworthily limited PA-induced ROS generation and cardiomyocytes apoptosis.	ros	205-208	peroxiredoxin 4	Rattus norvegicus	149-154
34332981-0	2021	Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells.	ros	79-82	mitogen-activated protein kinase 8	Homo sapiens	83-86
34332981-9	2021	Furthermore, we found that the ROS-JNK pathway was obviously activated in the DCA combined sorafenib group.	ros	31-34	mitogen-activated protein kinase 8	Homo sapiens	35-38
34369076-0	2021	Caspase-3-mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway.	ros	79-82	caspase 3	Homo sapiens	0-9
34497345-4	2021	Under oxidative stress, TAZ protected stromal differentiation against oxidative damage by reducing intracellular ROS and enhancing cellular antioxidant capacity dependent on the Nrf2/ARE/Foxo1 pathway.	ros	113-116	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	24-27
34497345-6	2021	Additionally, silencing TAZ caused accumulation of intracellular ROS through heightening NOX activity whose blockade by APO reversed the disruption in stromal differentiation.	ros	65-68	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	24-27
34261981-7	2021	The pathogenic changes mentioned above were accompanied by an increase in intracellular ROS levels, LDH release, and endoplasmic reticulum stress-related signals in the LC-sera or TNFalpha-pretreated Caco-2 cells.	ros	88-91	tumor necrosis factor	Homo sapiens	180-188
34314818-4	2021	EAA pretreatment increased the HaCaT cell viability but suppressed ROS-mediated p53/POMC/alpha-MSH pathways in UVA-irradiated cells.	ros	67-70	tumor protein p53	Homo sapiens	80-83
34314818-4	2021	EAA pretreatment increased the HaCaT cell viability but suppressed ROS-mediated p53/POMC/alpha-MSH pathways in UVA-irradiated cells.	ros	67-70	proopiomelanocortin	Homo sapiens	84-88
34314818-4	2021	EAA pretreatment increased the HaCaT cell viability but suppressed ROS-mediated p53/POMC/alpha-MSH pathways in UVA-irradiated cells.	ros	67-70	STAM binding protein	Homo sapiens	89-98
34314818-7	2021	However, Nrf2 silencing reduced the EAA-mediated anti-melanogenic activity, evidenced by impaired antioxidant gene expression and uncontrolled ROS (H202) generation following UVA irradiation.	ros	143-146	NFE2 like bZIP transcription factor 2	Homo sapiens	9-13
34369076-7	2021	Furthermore, DOX treatments induced intracellular accumulation of ROS, stimulated the phosphorylation of JNK, and Caspase-3 activation, subsequently.	ros	66-69	caspase 3	Homo sapiens	114-123
34369076-8	2021	In conclusion, the study suggests that GSDME triggered DOX-induced pyroptosis in the caspase-3 dependent reactions through the ROS/JNK signalling pathway.	ros	127-130	caspase 3	Homo sapiens	85-94
34369076-8	2021	In conclusion, the study suggests that GSDME triggered DOX-induced pyroptosis in the caspase-3 dependent reactions through the ROS/JNK signalling pathway.	ros	127-130	mitogen-activated protein kinase 8	Homo sapiens	131-134
34252711-0	2021	Targeting IFN-gamma-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.	ros	112-115	IFI30 lysosomal thiol reductase	Homo sapiens	10-55
34331475-0	2021	Curcumin induced G2/M cycle arrest in SK-N-SH neuroblastoma cells through the ROS-mediated p53 signaling pathway.	ros	78-81	tumor protein p53	Homo sapiens	91-94
34331475-6	2021	Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways.	ros	67-70	tumor protein p53	Homo sapiens	107-110
34331475-6	2021	Furthermore, curcumin promoted the overproduction of intracellular ROS and apoptosis induced by activating p53 and Bcl-2 signal pathways.	ros	67-70	BCL2 apoptosis regulator	Homo sapiens	115-120
34252711-5	2021	Further mechanistic findings revealed that the ROS-mediated mitochondrial damage plays a pivotal role in inducing apoptosis of GILT-inhibited AML cells after Ara-C treatment.	ros	47-50	IFI30 lysosomal thiol reductase	Homo sapiens	127-131
34252711-8	2021	Taken together, our work demonstrated that the inhibition of GILT increases AML chemo-sensitivity through elevating ROS level and induce oxidative mitochondrial damage-mediated apoptosis, and inhibition of the PI3K/Akt/NRF2 pathway enhances the intracellular oxidative state by disrupting redox homeostasis, providing a potentially effective way to overcome chemoresistance of AML.	ros	116-119	IFI30 lysosomal thiol reductase	Homo sapiens	61-65
34439562-7	2021	Moreover, the curcumin-induced reduction in ROS generation decreased the nuclear translocation of Nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of phase-II detoxifying enzymes.	ros	44-47	NFE2 like bZIP transcription factor 2	Homo sapiens	98-141
34462562-5	2021	Furthermore, MCP treatment decreased ROS level in TAM through its reducibility and inhibiting galectin-3 expression, leading to inhibition of glucose transporter-1 expression and glucose uptake.	ros	37-40	lectin, galactose binding, soluble 3	Mus musculus	94-104
34217685-0	2021	Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation.	ros	61-64	GLI family zinc finger 2	Homo sapiens	18-23
34217685-0	2021	Luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation.	ros	61-64	NFE2 like bZIP transcription factor 2	Homo sapiens	80-84
34217685-4	2021	Moreover, luteolin was found to significantly reduce the expression of NLRP3, pro-CASP-1 and CASP-1, which are the key components of NLRP3 inflammasome, as well as the expression of N-GSDMD and IL-1beta, and we proved that the inhibition of luteolin on NLRP3 inflammasome activation is ROS-dependent.	ros	286-289	NLR family pyrin domain containing 3	Homo sapiens	253-258
34217685-5	2021	Furthermore, it was demonstrated that luteolin promoted Nrf2 nuclear translocation, thereby increasing the expression of HO-1 that reduces ROS production, while the anti-pyroptotic effect of luteolin was reversed by a specific Nrf2 inhibitor.	ros	139-142	NFE2 like bZIP transcription factor 2	Homo sapiens	56-60
34217685-7	2021	In summary, we conclude that luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation as well as NF-kappaB inactivation.	ros	90-93	GLI family zinc finger 2	Homo sapiens	47-52
34217685-7	2021	In summary, we conclude that luteolin prevents THP-1 macrophage pyroptosis by suppressing ROS production via Nrf2 activation as well as NF-kappaB inactivation.	ros	90-93	NFE2 like bZIP transcription factor 2	Homo sapiens	109-113
34144504-9	2021	miR-137 mimic increased ROS generation, as well as reduced GSH and SOD levels, whereas miR-137 inhibitor exerted opposing effect.	ros	24-27	microRNA 137	Homo sapiens	0-7
34578877-6	2021	The increased expression of NQO1 (~90%) was associated with increased ROS generation.	ros	70-73	NAD(P)H quinone dehydrogenase 1	Homo sapiens	28-32
34126197-9	2021	Green tea extract and EGCG could significantly decrease ROS levels, the phosphorylation of Smad2/3, the translocation, DNA binding, and activity of Smads in cervical cancer cell lines treated with TGF-beta1 (p<0.01).	ros	56-59	transforming growth factor beta 1	Homo sapiens	197-206
34439562-7	2021	Moreover, the curcumin-induced reduction in ROS generation decreased the nuclear translocation of Nuclear factor erythroid-2-related factor 2 (Nrf2) and the expression of phase-II detoxifying enzymes.	ros	44-47	NFE2 like bZIP transcription factor 2	Homo sapiens	143-147
34175438-0	2021	Transduced Tat-PRAS40 prevents dopaminergic neuronal cell death through ROS inhibition and interaction with 14-3-3sigma protein.	ros	72-75	AKT1 substrate 1	Homo sapiens	15-21
34245858-11	2021	The data suggest that Arf6 regulates energy metabolism, which may contribute to impaired phagocytosis, ROS production, and apoptosis in PMN-Arf6 cKO.	ros	103-106	ADP-ribosylation factor 6	Mus musculus	22-26
34214633-4	2021	The transcription factor, nuclear transcription factor erythroid 2p45 (NF-E2)-related factor 2 (NRF2) is a master switch in the cellular antioxidant signaling and plays a vital role in adaptive survival response to ROS-induced oxidative stress.	ros	215-218	NFE2 like bZIP transcription factor 2	Homo sapiens	96-100
34175438-4	2021	Our results showed that Tat-PRAS40 effectively transduced into SH-SY5Y cells and inhibited DNA damage, ROS generation, and apoptotic signaling in MPP+-induced SH-SY5Y cells.	ros	103-106	AKT1 substrate 1	Homo sapiens	28-34
34252538-4	2021	In addition, PGC-1alpha that accumulates in TNF null mice, a major participant of mitochondrial metabolism, downregulated ROS activity and the expressions of M1-specific mRNA.	ros	122-125	tumor necrosis factor	Mus musculus	44-47
34485154-8	2021	5-FU promoted the expression of Keap1 and increased the binding to NF-E2-related factor 2 (Nrf2) to reduce the nuclear translocation of Nrf2, thereby weakening the transcriptional activity of Nrf2 to inhibit the expression of HO-1; reducing the activity of GSH, SOD, and CAT to increase ROS content; and aggravating DNA damage (indicated by the increase in 8-OHdG).	ros	287-290	NFE2 like bZIP transcription factor 2	Homo sapiens	67-89
34901534-6	2022	When HL-60 cells were treated by Au@Ce NPs, the removal of endogenous ROS signal significantly arrested cell cycle at G1 phase and suppressed the cell proliferation by blocking the mitogen-activated protein kinases (MAPKs) signaling and the Akt/Cyclin D1 cell cycle signaling.	ros	70-73	AKT serine/threonine kinase 1	Homo sapiens	241-244
34485154-8	2021	5-FU promoted the expression of Keap1 and increased the binding to NF-E2-related factor 2 (Nrf2) to reduce the nuclear translocation of Nrf2, thereby weakening the transcriptional activity of Nrf2 to inhibit the expression of HO-1; reducing the activity of GSH, SOD, and CAT to increase ROS content; and aggravating DNA damage (indicated by the increase in 8-OHdG).	ros	287-290	NFE2 like bZIP transcription factor 2	Homo sapiens	91-95
34485154-8	2021	5-FU promoted the expression of Keap1 and increased the binding to NF-E2-related factor 2 (Nrf2) to reduce the nuclear translocation of Nrf2, thereby weakening the transcriptional activity of Nrf2 to inhibit the expression of HO-1; reducing the activity of GSH, SOD, and CAT to increase ROS content; and aggravating DNA damage (indicated by the increase in 8-OHdG).	ros	287-290	NFE2 like bZIP transcription factor 2	Homo sapiens	136-140
34421605-7	2021	In contrast, imipramine enhanced the release of ROS by neutrophils during adhesion to fibronectin and stimulated apoptosis.	ros	48-51	fibronectin 1	Homo sapiens	86-97
34400737-3	2021	Here, we found that the administration of VVPF to CCl4-intoxicated rats for ten days was obviously ameliorated the CCl4-induced systemic elevation in ROS, NO and TBARS levels, as well as MPO activity.	ros	150-153	C-C motif chemokine ligand 4	Rattus norvegicus	50-54
34400737-3	2021	Here, we found that the administration of VVPF to CCl4-intoxicated rats for ten days was obviously ameliorated the CCl4-induced systemic elevation in ROS, NO and TBARS levels, as well as MPO activity.	ros	150-153	C-C motif chemokine ligand 4	Rattus norvegicus	115-119
34400737-5	2021	Furthermore, the gene expression of the ROS-related necroinflammatory mediators (NF-kappaB, iNOS, COX-2, and TNF-alpha) in the kidney, brain, and spleen, as well as IL-1beta, and IL-8 in the lung were greatly restored.	ros	40-43	nitric oxide synthase 2	Rattus norvegicus	92-96
34400737-5	2021	Furthermore, the gene expression of the ROS-related necroinflammatory mediators (NF-kappaB, iNOS, COX-2, and TNF-alpha) in the kidney, brain, and spleen, as well as IL-1beta, and IL-8 in the lung were greatly restored.	ros	40-43	tumor necrosis factor	Rattus norvegicus	109-118
34400737-5	2021	Furthermore, the gene expression of the ROS-related necroinflammatory mediators (NF-kappaB, iNOS, COX-2, and TNF-alpha) in the kidney, brain, and spleen, as well as IL-1beta, and IL-8 in the lung were greatly restored.	ros	40-43	interleukin 1 alpha	Rattus norvegicus	165-173
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	ros	2-5	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	ros	231-234	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
34901531-6	2022	Benefiting from the inflammation-homing effect of the macrophage membrane, the nanosystem delivers payloads (diagnostic probe and therapeutic drugs) to inflammatory lesions more efficiently and releases a chromophore and two drugs upon being triggered by the overexpressed in-situ ROS, thus exhibiting better theranostic performance in the autoimmune hepatitis and hind paw edema mouse models, including more salient imaging signals and better therapeutic efficacy via inhibiting NF-kappaB pathway and suppressing NLRP3 inflammasome activation.	ros	281-284	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	480-489
34434890-5	2021	Our data demonstrated that the silencing of circFNDC3B by shRNA inhibited GPX4 and SLC7A11 expression and enhanced ROS, iron, and Fe2+ levels in OSCC cells.	ros	115-118	fibronectin type III domain containing 3B	Mus musculus	44-54
34458695-0	2021	Alzheimer"s Abeta assembly binds sodium pump and blocks endothelial NOS activity via ROS-PKC pathway in brain vascular endothelial cells.	ros	85-88	nitric oxide synthase 3	Homo sapiens	56-71
34353364-10	2021	RESULTS: The in vitro results showed that BK suppressed H2O2-induced hCPCs apoptosis and ROS production in a concentration-dependent manner by promoting pAkt and Bcl-2 expression and reducing cleaved caspase 3 and Bax expression.	ros	89-92	synaptotagmin 17	Rattus norvegicus	42-44
34458695-4	2021	ASPD-NAKalpha3 interaction elicits neurodegeneration through calcium overload in neurons, while the same interaction suppresses vasorelaxation by increasing the inactive form of endothelial nitric oxide synthase (eNOS) in endothelial cells via mitochondrial ROS and protein kinase C, independently of the physiological relaxation system.	ros	258-261	nitric oxide synthase 3	Homo sapiens	178-211
34458695-4	2021	ASPD-NAKalpha3 interaction elicits neurodegeneration through calcium overload in neurons, while the same interaction suppresses vasorelaxation by increasing the inactive form of endothelial nitric oxide synthase (eNOS) in endothelial cells via mitochondrial ROS and protein kinase C, independently of the physiological relaxation system.	ros	258-261	nitric oxide synthase 3	Homo sapiens	213-217
34130142-0	2021	Tumor progress intercept by intervening in Caveolin-1 related intercellular communication via ROS-sensitive c-Myc targeting therapy.	ros	94-97	caveolin 1	Homo sapiens	43-53
34118452-4	2021	Accumulation of damaged ROS-generating mitochondria, accompanied by the release of mitochondrial DAMPs, can activate PRRs such as the NLRP3 inflammasome, TLR9, cGAS/STING, and ZBP1.	ros	24-27	NLR family pyrin domain containing 3	Homo sapiens	134-139
34118452-4	2021	Accumulation of damaged ROS-generating mitochondria, accompanied by the release of mitochondrial DAMPs, can activate PRRs such as the NLRP3 inflammasome, TLR9, cGAS/STING, and ZBP1.	ros	24-27	Z-DNA binding protein 1	Homo sapiens	176-180
34342168-6	2021	Finally, we found that GLDC expression is linked to glutathione levels, with increased expression associated with elevated levels of glutathione and reduced expression associated with a suppression of glutathione and increased cellular ROS levels.	ros	236-239	glycine decarboxylase	Mus musculus	23-27
34229586-4	2021	Then, the PRP-derived exosomes (PRP-exo) were isolated and purified, and we noticed that both PRP-exo and ROS scavenger (NAC) reversed the detrimental effects of H2O2 treatment on the nucleus pulposus (NP) cells.	ros	106-109	proline rich protein HaeIII subfamily 1	Mus musculus	10-13
34351541-8	2021	CONCLUSION: Taken together, these data suggested that the simultaneous modification of homologous gene copies of WRKY are established using CRISPR/Cas9 system in A. thaliana and the loss of AtWRKY3 and AtWRKY4 has an effect on ROS scavenging pathways to reduce stress tolerance.	ros	227-230	WRKY DNA-binding protein 4	Arabidopsis thaliana	202-209
34267821-9	2021	The present study suggested that PEDF may exert antitumor effects in AGE-exposed breast cancer cells by suppressing NADPH oxidase-induced ROS generation and VEGF and MMP-9 expression via interaction with LR.	ros	138-141	renin binding protein	Homo sapiens	69-72
34330116-14	2021	The mechanism of FA-BSANPs/BA promoting apoptosis of breast cancer may be due to its action on the caspase-8/Bid/ROS pathway.	ros	113-116	BH3 interacting domain death agonist	Homo sapiens	109-112
34301789-7	2021	Our studies reveal an unexpected role for mitochondria downstream of NPM1c and implicate a mitochondrial/ROS/PML/TP53 senescence pathway as an effector of ActD-based therapies.	ros	105-108	tumor protein p53	Homo sapiens	113-117
34442404-17	2021	Indeed, low expression of WDR4 contributed to ROS-induced DNA fragmentation.	ros	46-49	WD repeat domain 4	Mus musculus	26-30
34395402-10	2021	Interfering with Rnase6 expression or overexpressing DNMT1 in OX-LDL stimulated MOVAS inhibited cell proliferation and migration, decreased ROS content and inflammatory factor secretion, and inhibited PI3K pathway protein expression.	ros	140-143	ribonuclease, RNase A family, 6	Mus musculus	17-23
34395402-10	2021	Interfering with Rnase6 expression or overexpressing DNMT1 in OX-LDL stimulated MOVAS inhibited cell proliferation and migration, decreased ROS content and inflammatory factor secretion, and inhibited PI3K pathway protein expression.	ros	140-143	DNA methyltransferase (cytosine-5) 1	Mus musculus	53-58
34395402-13	2021	Conclusion: Hypomethylation of the promoter of Rnase6 enhanced the proliferation and migration of OX-LDL treated MOVAS, upregulated ROS content and inflammatory factor secretion levels in the cells, and activated the PI3K/Akt signaling pathway.	ros	132-135	ribonuclease, RNase A family, 6	Mus musculus	47-53
34315493-10	2021	Furthermore, protopine also induced accumulation of intracellular ROS which further led to the inhibition of PI3K/Akt signalling pathway.	ros	66-69	thymoma viral proto-oncogene 1	Mus musculus	114-117
34256772-10	2021	Interestingly, IFN-alpha is capable of inducing ROS and ATP production in CD4+ T cells, while knockdown of tRF-3009 reversed this process.	ros	48-51	interferon alpha 1	Homo sapiens	15-24
34292112-3	2022	The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway.	ros	124-127	sirtuin 1	Rattus norvegicus	143-148
34292112-3	2022	The results showed that quercetin significantly reduced cerebral infarct volume, neurological deficit, BBB permeability and ROS generation via Sirt1/Nrf2/HO-1 signaling pathway.	ros	124-127	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
34256772-11	2021	Overexpression of tRF-3009 in CD4+ T cells alone was sufficient to upregulate OCR, ROS, and ATP production.	ros	83-86	CD4 molecule	Homo sapiens	30-33
34294686-5	2021	Moreover, ROS generation elicited by afatinib was responsible for the induction of the REDD1-TSC1-mTORC1 axis.	ros	10-13	TSC complex subunit 1	Homo sapiens	93-97
34294688-8	2021	In addition, expressing mitochondria-targeted ER-beta in breast cancer cells resulted in decreased mitochondrial respiration alongside increased total ROS and mitochondrial superoxide production.	ros	151-154	estrogen receptor 1	Homo sapiens	46-53
34256772-10	2021	Interestingly, IFN-alpha is capable of inducing ROS and ATP production in CD4+ T cells, while knockdown of tRF-3009 reversed this process.	ros	48-51	CD4 molecule	Homo sapiens	74-77
34305621-8	2021	The effects of CAV1 on fat accumulation, ROS, and the AMPK/Nrf2 anti-oxidative pathway were reduced after the application of CAV1-siRNA.	ros	41-44	caveolin 1	Homo sapiens	125-129
34238104-8	2021	Moreover, the results of IHC showed that the miR-494 antagomir downregulated p65 NF-kappaB in kidney tissues from the LPS-induced AKI mice, accompanied by decreased levels of TNF-alpha, IL-1beta, IL-6, MDA, NO, and ROS but increased levels of SOD and GSH.	ros	215-218	microRNA 494	Mus musculus	45-52
34256834-0	2021	Ferulic acid inhibits LPS-induced apoptosis in bovine mammary epithelial cells by regulating the NF-kappaB and Nrf2 signalling pathways to restore mitochondrial dynamics and ROS generation.	ros	174-177	NFE2 like bZIP transcription factor 2	Bos taurus	111-115
34356326-3	2021	Supplementation of MSC in KYAT1 overexpressed cells resulted in significantly increased cytotoxicity, due to ROS formation, as compared to MSC alone.	ros	109-112	kynurenine aminotransferase 1	Homo sapiens	26-31
34307357-8	2021	In addition, mitochondrial dysfunction may amplify the activation of NLRP3 through the production of mitochondrial ROS, which together aggravate accumulating mitochondrial damage.	ros	115-118	NLR family pyrin domain containing 3	Homo sapiens	69-74
34234193-5	2021	Transfection of si-FOXO3a in HDF increased ROS levels, while wt-FOXO3a-transfected AsPC-1 cells decreased ROS levels.	ros	43-46	forkhead box O3	Homo sapiens	19-25
34137412-9	2021	The synergistic effect jointly caused a burst generation of mitochondrial ROS, which significantly down-regulated Bcl-2 protein expression, accelerated cytochrome c release and triggered a cascade of apoptosis-related proteins of Caspase-3 and Caspase-9.	ros	74-77	BCL2 apoptosis regulator	Homo sapiens	114-119
34137412-9	2021	The synergistic effect jointly caused a burst generation of mitochondrial ROS, which significantly down-regulated Bcl-2 protein expression, accelerated cytochrome c release and triggered a cascade of apoptosis-related proteins of Caspase-3 and Caspase-9.	ros	74-77	cytochrome c, somatic	Homo sapiens	152-164
34137412-9	2021	The synergistic effect jointly caused a burst generation of mitochondrial ROS, which significantly down-regulated Bcl-2 protein expression, accelerated cytochrome c release and triggered a cascade of apoptosis-related proteins of Caspase-3 and Caspase-9.	ros	74-77	caspase 3	Homo sapiens	230-239
34234193-5	2021	Transfection of si-FOXO3a in HDF increased ROS levels, while wt-FOXO3a-transfected AsPC-1 cells decreased ROS levels.	ros	106-109	forkhead box O3	Homo sapiens	64-70
34234193-10	2021	Our results suggest that metformin in cancer cells differentially regulates cellular ROS levels via AMPK-FOXO3a-MnSOD pathway and combination of metformin/apigenin exerts anticancer activity through DNA damage-induced apoptosis, autophagy and necroptosis by cancer cell-specific ROS amplification.	ros	85-88	superoxide dismutase 2, mitochondrial	Mus musculus	112-117
34430599-8	2021	In contrast, TGR5 activation inhibited ROS production, secretion of pro-inflammatory cytokines, and M1-predominant polarization of Kupffer cells.	ros	39-42	G protein-coupled bile acid receptor 1	Homo sapiens	13-17
34295325-14	2021	Furthermore, glucagon impaired zymosan-A-induced ROS production by neutrophils in vitro.	ros	49-52	glucagon	Homo sapiens	13-21
34262322-12	2021	Silencing Nrf2 abrogated the inhibitory effects of fisetin on LPS-induced pro-inflammatory cytokines TNF-alpha, IL-1beta secretion, NADPH oxidase-4 (Nox4) and ROS production.	ros	159-162	NFE2 like bZIP transcription factor 2	Bos taurus	10-14
34430599-11	2021	Conclusions: TGR5 activation protected against BDL-induced CLD by both suppressing inflammation via inhibiting the NF-kappaB pathway and reducing ROS production via activation of Nrf2/HO-1 signaling.	ros	146-149	G protein-coupled bile acid receptor 1	Homo sapiens	13-17
34209765-9	2021	The relationship between derangement of SIRT3 signaling and the imbalance of ROS and antioxidant defenses in testes has also been demonstrated.	ros	77-80	sirtuin 3	Homo sapiens	40-45
34337709-0	2021	MiR-124 affects the apoptosis of brain vascular endothelial cells and ROS production through regulating PI3K/AKT signaling pathway.	ros	70-73	AKT serine/threonine kinase 1	Homo sapiens	109-112
34181104-9	2021	ROS level increased in cells transfected with Apaf-1 and induced mitochondrial permeability for cytochrome c release, which subsequently promoted apoptosome formation, intrinsic apoptosis and ATP depletion.	ros	0-3	apoptotic peptidase activating factor 1	Homo sapiens	46-52
34183754-10	2022	ADT enhanced mitochondrial ROS production thus inducing mitochondrial uncoupling and activating UCP2 in microglia.	ros	27-30	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	96-100
34176927-5	2021	In HeLa and 4T1 cells, LDHA or LDHB knockout or LDH inhibitor FX11 significantly decreased ROS induction by modulators of the mitochondrial electron transfer chain (antimycin, oligomycin, rotenone), hypoxia, and pharmacological ROS inducers piperlogumine (PL) and phenethyl isothiocyanate (PEITC).	ros	91-94	lactate dehydrogenase A	Homo sapiens	48-51
34181104-9	2021	ROS level increased in cells transfected with Apaf-1 and induced mitochondrial permeability for cytochrome c release, which subsequently promoted apoptosome formation, intrinsic apoptosis and ATP depletion.	ros	0-3	cytochrome c, somatic	Homo sapiens	96-108
34206503-5	2021	The transcription factor Nrf2 regulates expression of a bundle of ROS detoxifying genes.	ros	66-69	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
34222364-3	2021	Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) coactivator-1alpha (PGC-1alpha) is vital to the function of mitochondria, which contributes to the energy production and reactive oxidative species (ROS)-scavenging activity in the heart.	ros	211-214	peroxisome proliferator activated receptor gamma	Homo sapiens	0-48
34206708-9	2021	Importantly, while stimulating the production of ROS, Angiotensin-II at the same time decreases the generation of NO.	ros	49-52	angiotensinogen	Homo sapiens	54-68
34222364-3	2021	Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) coactivator-1alpha (PGC-1alpha) is vital to the function of mitochondria, which contributes to the energy production and reactive oxidative species (ROS)-scavenging activity in the heart.	ros	211-214	PPARG coactivator 1 alpha	Homo sapiens	50-80
34222364-3	2021	Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) coactivator-1alpha (PGC-1alpha) is vital to the function of mitochondria, which contributes to the energy production and reactive oxidative species (ROS)-scavenging activity in the heart.	ros	211-214	PPARG coactivator 1 alpha	Homo sapiens	82-92
34135327-5	2021	Pharmacological promotion of glycolysis induces ROS-dependent upregulation of the mitochondrial metabolic regulator, peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), thereby restoring epithelial barrier function, improving viral defense, and attenuating disease pathology.	ros	48-51	PPARG coactivator 1 alpha	Homo sapiens	117-184
34107901-13	2021	The knockout of adiponectin gene by siRNA increased ROS production, resulting in the activation of NLRP3 inflammasome and the phosphorylation of NF-kappaB in podocytes.	ros	52-55	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	145-154
34135327-5	2021	Pharmacological promotion of glycolysis induces ROS-dependent upregulation of the mitochondrial metabolic regulator, peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha), thereby restoring epithelial barrier function, improving viral defense, and attenuating disease pathology.	ros	48-51	PPARG coactivator 1 alpha	Homo sapiens	186-196
34203664-9	2021	Here, we show that Flt3-ITD+ cells are sensitive to an IB-induced dynamin 1-like (Drp1)-p38-ROS pathway.	ros	92-95	fms related receptor tyrosine kinase 3	Homo sapiens	19-23
34203664-9	2021	Here, we show that Flt3-ITD+ cells are sensitive to an IB-induced dynamin 1-like (Drp1)-p38-ROS pathway.	ros	92-95	mitogen-activated protein kinase 14	Homo sapiens	88-91
34234852-8	2021	Mechanistically, STAT3 upregulates V-ATPase expression while blockade of STAT3 activity repressed V-ATPase expression in these tumor cells as well as sensitized cells to anoikis, increased ROS production, and misfolded protein accumulation.	ros	189-192	signal transducer and activator of transcription 3	Homo sapiens	17-22
34234852-8	2021	Mechanistically, STAT3 upregulates V-ATPase expression while blockade of STAT3 activity repressed V-ATPase expression in these tumor cells as well as sensitized cells to anoikis, increased ROS production, and misfolded protein accumulation.	ros	189-192	signal transducer and activator of transcription 3	Homo sapiens	73-78
34107901-15	2021	CONCLUSIONS: Our study showed that adiponectin ameliorated PA-induced podocyte injury in vitro and HFD-induced injury in vivo via inhibiting the ROS/NF-kappaB/NLRP3 pathway.	ros	145-148	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
34072471-5	2021	The obtained results strongly support the carcinogenic potential of beta-HCH, which is achieved through both non-genotoxic (activation of oncogenic signaling pathways and proliferative activity) and indirect genotoxic (ROS production and DNA damage) mechanisms that significantly affect cellular macroscopic characteristics and functions such as cell morphology, cell cycle profile, and apoptosis.	ros	219-222	nuclear receptor subfamily 0 group B member 1	Homo sapiens	68-76
34141616-7	2021	Moreover, the ROS-dependent damaging effects of radiation therapy are hampered by the induction of antioxidant enzymes by NF-kappaB, NRF2, and HIF-1.	ros	14-17	nuclear factor kappa B subunit 1	Homo sapiens	122-131
34141616-7	2021	Moreover, the ROS-dependent damaging effects of radiation therapy are hampered by the induction of antioxidant enzymes by NF-kappaB, NRF2, and HIF-1.	ros	14-17	NFE2 like bZIP transcription factor 2	Homo sapiens	133-137
34141616-7	2021	Moreover, the ROS-dependent damaging effects of radiation therapy are hampered by the induction of antioxidant enzymes by NF-kappaB, NRF2, and HIF-1.	ros	14-17	hypoxia inducible factor 1 subunit alpha	Homo sapiens	143-148
34483444-5	2021	Objective: To find out ROS involvement in undescended testis and efficacy of EPO as an additional therapy for undescended testis.	ros	23-26	erythropoietin	Homo sapiens	77-80
34208283-11	2021	Tariquidar enhanced Dox cytotoxicity by increasing intracellular ROS production leading to caspase-3 mediated apoptosis.	ros	65-68	caspase 3	Homo sapiens	91-100
34060394-5	2022	Moreover, this agent induced ROS-mediated apoptosis by altering the expression of Bax, Bim, Caspase3, Bcl2, and XIAP.	ros	29-32	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
34060394-5	2022	Moreover, this agent induced ROS-mediated apoptosis by altering the expression of Bax, Bim, Caspase3, Bcl2, and XIAP.	ros	29-32	caspase 3	Homo sapiens	92-100
34060394-5	2022	Moreover, this agent induced ROS-mediated apoptosis by altering the expression of Bax, Bim, Caspase3, Bcl2, and XIAP.	ros	29-32	BCL2 apoptosis regulator	Homo sapiens	102-106
34067282-4	2021	AGE/RAGE signaling has been shown to alter protein expression and ROS production in cardiac fibroblasts, resulting in changes in cellular function, such as migration and contraction.	ros	66-69	advanced glycosylation end product-specific receptor	Mus musculus	4-8
34071270-2	2021	PGC1alpha has been implicated in the control of mitochondrial biogenesis, the regulation of the synthesis of ROS and inflammatory cytokines, as well as genes controlling metabolic processes.	ros	109-112	PPARG coactivator 1 alpha	Homo sapiens	0-9
34073310-6	2021	The upregulation of the P2X7 receptor (P2X7R) also seems to be involved, causing pro-inflammatory cytokines and ROS release by macrophages and microglia, contributing to neuroinflammatory and neurodegenerative progression in RP.	ros	112-115	purinergic receptor P2X 7	Homo sapiens	24-37
34073310-6	2021	The upregulation of the P2X7 receptor (P2X7R) also seems to be involved, causing pro-inflammatory cytokines and ROS release by macrophages and microglia, contributing to neuroinflammatory and neurodegenerative progression in RP.	ros	112-115	purinergic receptor P2X 7	Homo sapiens	39-44
34071911-9	2021	In HT22 cells, the CH2Cl2-soluble fraction inhibited cell damage and ROS production caused by glutamate via the regulation of HO-1.	ros	69-72	heme oxygenase 1	Mus musculus	126-130
34123848-6	2021	Mechanically, we observed that DPP-4i treatment induced aberrant oxidative stress by triggering ROS overproduction, as well as ROS-dependent NRF2 and HO-1 activations in BC cells, while specific inhibition of ROS, NRF2 or HO-1 activations abrogated DPP-4i-driven BC metastasis and metastasis-associated gene expression in vitro.	ros	127-130	nuclear factor, erythroid derived 2, like 2	Mus musculus	141-145
34123848-6	2021	Mechanically, we observed that DPP-4i treatment induced aberrant oxidative stress by triggering ROS overproduction, as well as ROS-dependent NRF2 and HO-1 activations in BC cells, while specific inhibition of ROS, NRF2 or HO-1 activations abrogated DPP-4i-driven BC metastasis and metastasis-associated gene expression in vitro.	ros	127-130	heme oxygenase 1	Mus musculus	150-154
34067282-10	2021	The results showed Rap1a overlaps the AGE/RAGE cascade to increase the myofibroblast population and generation of ROS production.	ros	114-117	advanced glycosylation end product-specific receptor	Mus musculus	42-46
34821332-5	2021	In a cell assay, this nanoplatform could function as an antagonist of GPX4 and agonist of SOD-1, resulting in intracellular ROS and H2O2 accumulation.	ros	124-127	superoxide dismutase 1	Homo sapiens	90-95
34084175-0	2021	Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways.	ros	219-222	caspase 14	Mus musculus	36-52
34065695-8	2021	AKT phosphorylation was regulated by AKR1C3 and might be responsible for eliminating over-produced ROS in EAC cells.	ros	99-102	thymoma viral proto-oncogene 1	Mus musculus	0-3
34065695-10	2021	Here, we reported for the first time that AKR1C3 renders chemotherapy resistance through controlling ROS levels via AKT signaling in EAC cells.	ros	101-104	thymoma viral proto-oncogene 1	Mus musculus	116-119
34485982-0	2021	Activation of P53 Via Nutlin-3a Reveals Role for P53 In ROS Signaling During Cardiac Differentiation of hiPSCs.	ros	56-59	tumor protein p53	Homo sapiens	49-52
34195594-2	2021	As such, the Nrf2 pathway is critical in guarding the cell from the harmful effects of excessive reactive oxygen species/reactive nitrogen species (ROS/RNS) and in maintaining cellular redox balance.	ros	148-151	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
35525345-0	2022	Arsenic exposure elevated ROS promotes energy metabolic reprogramming with enhanced AKT-dependent HK2 expression.	ros	26-29	AKT serine/threonine kinase 1	Homo sapiens	84-87
35525345-10	2022	Taken together, our results indicated that ROS induced by low-dose arsenic exposure determined energy metabolic reprogramming and acted a critical regulator for AKT-dependent HK2 expression and aerobic glycolysis.	ros	43-46	AKT serine/threonine kinase 1	Homo sapiens	161-164
34062539-10	2021	Ang II infusion promoted mitochondrial damage, as indicated by TEM, and induced mitochondrial dysfunction, as evidenced by downregulation of PGC-1alpha, TFAM, and increased mitochondrial ROS.	ros	187-190	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	0-6
35525345-8	2022	Further studies showed accumulated ROS determined the metabolic reprogramming via activating AKT and then increasing HK2 expression.	ros	35-38	AKT serine/threonine kinase 1	Homo sapiens	93-96
35490584-7	2022	Notably, compound 7w, which had the highest activity and low cytotoxicity, was demonstrated to remarkably reduce intracellular ROS accumulation by activating the mRNA expression of Nrf2 and its downstream antioxidant gene HO-1, indicating a novel promising antioxidant and Nrf2 activator.	ros	127-130	NFE2 like bZIP transcription factor 2	Rattus norvegicus	181-185
35460909-10	2022	Moreover, SIL/BSA nanoparticles exhibited antioxidant effects against intracellular oxidative stress via upregulating the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant responsive element (ARE) pathway, decreasing ROS and regulating antioxidant enzyme reactivity.	ros	230-233	nuclear factor, erythroid derived 2, like 2	Mus musculus	167-171
35348973-5	2022	Asiatic acid suppressed CYP2E1 activity and NADP+/NADPH ratio, resulting in low ROS production.	ros	80-83	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	24-30
35500642-12	2022	Thus, we conclude that astaxanthin protected the retinal cells from HG-induced inflammation by modulating the NF-kappaB through ROS-PI3K/Akt signaling cascade.	ros	128-131	nuclear factor kappa B subunit 1	Homo sapiens	110-119
35500642-12	2022	Thus, we conclude that astaxanthin protected the retinal cells from HG-induced inflammation by modulating the NF-kappaB through ROS-PI3K/Akt signaling cascade.	ros	128-131	AKT serine/threonine kinase 1	Homo sapiens	137-140
35490584-7	2022	Notably, compound 7w, which had the highest activity and low cytotoxicity, was demonstrated to remarkably reduce intracellular ROS accumulation by activating the mRNA expression of Nrf2 and its downstream antioxidant gene HO-1, indicating a novel promising antioxidant and Nrf2 activator.	ros	127-130	NFE2 like bZIP transcription factor 2	Rattus norvegicus	273-277
35346830-9	2022	This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers.	ros	62-65	NLR family pyrin domain containing 3	Homo sapiens	99-104
35585170-15	2022	In conclusion, in utero hypoxia reduced ACh-mediated vasodilatation in ovine MCA predominantly via decreased CHRM3 and p-NOS3, and the decreased NOS3 bioactivities might be attributed to ROS and ERK1/2.	ros	187-190	nitric oxide synthase, endothelial	Ovis aries	145-149
35617999-13	2022	These events were dependent on TLR2/MyD88/TRAF6- and PI3K/Akt/NADPH oxidase/ROS-regulated NF-kappaB activation.	ros	76-79	AKT serine/threonine kinase 1	Homo sapiens	58-61
35617999-13	2022	These events were dependent on TLR2/MyD88/TRAF6- and PI3K/Akt/NADPH oxidase/ROS-regulated NF-kappaB activation.	ros	76-79	nuclear factor kappa B subunit 1	Homo sapiens	90-99
35617999-15	2022	To conclude, CO released from CORM-2 can prevent the LTA-stimulated HGFs from increasing VCAM-1 and ICAM-1 expression and promoting monocyte adhesion by inhibiting TLR2/MyD88/TRAF6 association and PI3K/Akt/NADPH oxidase/ROS signaling, both converge on the canonical NF-kappaB activation.	ros	220-223	toll like receptor 2	Homo sapiens	164-168
35460707-2	2022	The Nrf2 should undergo nuclear translocation to exert its protective impacts and decrease ROS production.	ros	91-94	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
35583119-5	2022	CNPs significantly increased the level of ROS to regulate ERK/JNK signaling, which would further induce resistant cell apoptosis.	ros	42-45	mitogen-activated protein kinase 1	Homo sapiens	58-61
35460707-7	2022	The Nrf2 enhances activity of antioxidant enzymes to reduce ROS production and prevent oxidative stress-mediated cell death.	ros	60-63	NFE2 like bZIP transcription factor 2	Homo sapiens	4-8
35526324-0	2022	Bcl-xL is required for the protective effects of low-dose berberine against doxorubicin-induced cardiotoxicity through blocking apoptosis and activating mitophagy-mediated ROS elimination.	ros	172-175	BCL2 like 1	Homo sapiens	0-6
35533575-3	2022	We discovered that myoferlin targeting with WJ460 pharmacological compound triggered mitophagy and ROS accumulation culminating with lipid peroxidation and apoptosis-independent cell death.	ros	99-102	myoferlin	Homo sapiens	19-28
35533575-5	2022	Mitophagy inhibitor Mdivi1 and iron chelators inhibited the myoferlin-related ROS production and restored cell growth.	ros	78-81	myoferlin	Homo sapiens	60-69
35636017-5	2022	Further results demonstrated that CPX could induce cytoprotective autophagy by downregulating the expression of PARK7 to activate PRKAA1 or by PARK7-independent accumulation of ROS to inhibit mTOR signaling.	ros	177-180	mechanistic target of rapamycin kinase	Homo sapiens	192-196
35182635-1	2022	In this study, novel porous sodalite (SOD) was synthesized through Reactive Oxidation Species (ROS) route from industrial waste lithium silicon fume (LSF) to stabilize nZVI (SOD@nZVI), and used as an outstanding persulfate (PS) activator for efficient organic degradation.	ros	95-98	superoxide dismutase 1	Homo sapiens	38-41
35199915-7	2022	The nimbolide treatment-induced ROS production by suppressing the expression of antioxidant regulatory enzymes, namely superoxide dismutase and catalase.	ros	32-35	catalase	Mus musculus	144-152
35583119-5	2022	CNPs significantly increased the level of ROS to regulate ERK/JNK signaling, which would further induce resistant cell apoptosis.	ros	42-45	mitogen-activated protein kinase 8	Homo sapiens	62-65
35616702-0	2022	Correction to: Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway.	ros	136-139	cadherin 1	Homo sapiens	50-60
35367811-6	2022	XBP1 deficiency increased ROS production to promote hepatocellular pyroptosis by activating NLRP3/caspase-1/GSDMD signaling, which facilitated the extracellular release of mtDNA.	ros	26-29	X-box binding protein 1	Mus musculus	0-4
35616096-3	2022	Herein, a novel ROS-dependent TRAIL-sensitizing nanoplatform, CPT MV, with a Ce6-PLGA core and a TRAIL-modified cell membrane shell was explored to improve the in vivo circulation stability of TRAIL and to amplify TRAIL-induced apoptosis.	ros	16-19	TNF superfamily member 10	Homo sapiens	30-35
35616096-3	2022	Herein, a novel ROS-dependent TRAIL-sensitizing nanoplatform, CPT MV, with a Ce6-PLGA core and a TRAIL-modified cell membrane shell was explored to improve the in vivo circulation stability of TRAIL and to amplify TRAIL-induced apoptosis.	ros	16-19	TNF superfamily member 10	Homo sapiens	97-102
35616096-3	2022	Herein, a novel ROS-dependent TRAIL-sensitizing nanoplatform, CPT MV, with a Ce6-PLGA core and a TRAIL-modified cell membrane shell was explored to improve the in vivo circulation stability of TRAIL and to amplify TRAIL-induced apoptosis.	ros	16-19	TNF superfamily member 10	Homo sapiens	193-198
35616096-3	2022	Herein, a novel ROS-dependent TRAIL-sensitizing nanoplatform, CPT MV, with a Ce6-PLGA core and a TRAIL-modified cell membrane shell was explored to improve the in vivo circulation stability of TRAIL and to amplify TRAIL-induced apoptosis.	ros	16-19	TNF superfamily member 10	Homo sapiens	214-219
35413643-0	2022	Caveolin-1 controls mitochondrial damage and ROS production by regulating fission - fusion dynamics and mitophagy.	ros	45-48	caveolin 1	Homo sapiens	0-10
35633418-3	2022	We have reported earlier that expression of human tau-transgene in Drosophila induces the expression of glob1, and its restored level restricts tau etiology by regulating tau hyperphosphorylation and ROS generation via GSK-3beta/p-Akt and Nrf2-keap1-ARE pathways, respectively.	ros	200-203	globin 1	Drosophila melanogaster	104-109
35617030-11	2022	These were prevented in Nox4-/- and by pharmacological inhibition of Nox4 or Rock.Commonly used chemotherapeutic agents, and in particular, docetaxel, alter vascular function by promoting inhibitory phosphorylation of eNOS and enhancing ROS production by NADPH oxidases.	ros	237-240	nitric oxide synthase 3	Homo sapiens	218-222
35616702-0	2022	Correction to: Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway.	ros	136-139	mitogen-activated protein kinase 1	Homo sapiens	140-143
35616799-5	2022	Also, sirtuins are known to deacetylate Nrf2 and contribute to its action of reducing ROS by generation of anti-oxidant enzymes.	ros	86-89	NFE2 like bZIP transcription factor 2	Homo sapiens	40-44
35624898-5	2022	This review focuses on the mechanisms regulating the mitochondrial formation of ROS after exposure to low concentrations of a specific arsenic compound, NaAsO2, and their crosstalk with the nuclear factor (erythroid-2 related) factor 2 antioxidant signaling and the endoplasmic reticulum stress response.	ros	80-83	NFE2 like bZIP transcription factor 2	Homo sapiens	190-235
35629435-0	2022	Translational Medicine in Uremic Vascular Calcification: Scavenging ROS Attenuates p-Cresyl Sulfate-Activated Caspase-1, NLRP3 Inflammasome and Eicosanoid Inflammation in Human Arterial Smooth Muscle Cells.	ros	68-71	NLR family pyrin domain containing 3	Homo sapiens	121-126
35472411-3	2022	There is a significant body of research investigating the effects of oxidative stress/ROS on ASM behaviour, falling into the following categories; cigarette smoke and associated compounds, air pollutants, aero-allergens, asthma and COPD relevant mediators, and the anti-oxidant Nrf2/HO-1 signalling pathway.	ros	86-89	NFE2 like bZIP transcription factor 2	Homo sapiens	278-282
35599281-0	2022	Synergistic antitumor effect of Andrographolide and cisplatin through ROS-mediated ER stress and STAT3 inhibition in colon cancer.	ros	70-73	signal transducer and activator of transcription 3	Homo sapiens	97-102
35599281-7	2022	Further studies showed that AP potentiates cisplatin-induced endoplasmic reticulum stress and STAT3 inhibition through increasing intracellular ROS.	ros	144-147	signal transducer and activator of transcription 3	Homo sapiens	94-99
35629435-10	2022	From bedside to bench, ROS scavenger attenuates PCS-activated expressions of cPLA2/COX2, pro-caspase-1 and NLRP3 in the HASMC model.	ros	23-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-87
35629435-10	2022	From bedside to bench, ROS scavenger attenuates PCS-activated expressions of cPLA2/COX2, pro-caspase-1 and NLRP3 in the HASMC model.	ros	23-26	NLR family pyrin domain containing 3	Homo sapiens	107-112
35581617-11	2022	The mechanism of these effects may be partly mediated by AGEs-RAGE-ROS pathway via the interaction with GLP-1 receptor.	ros	67-70	advanced glycosylation end product-specific receptor	Rattus norvegicus	62-66
35628508-9	2022	RAPA eliminates excessive ROS, inhibits NF-kappaB nuclear translocation and down-regulates the TXNIP/NLRP3 axis, consequently suppressing ROS-mediated NLRP3 inflammasome activation, which may be the underlying mechanism of the protective effect of autophagy on realgar-induced liver injury.	ros	138-141	thioredoxin interacting protein	Mus musculus	95-100
35624865-7	2022	In stretched macrophages, H2S prevented MIP-2 release by limiting nicotinamide adenine dinucleotide phosphate oxidase-derived superoxide radicals (ROS).	ros	147-150	chemokine (C-X-C motif) ligand 2	Mus musculus	40-45
35624865-9	2022	In neutrophils (Hoxb8), H2S limited MIP-2-induced transmigration through endothelial monolayers, ROS formation and their chemotactic movement.	ros	97-100	chemokine (C-X-C motif) ligand 2	Mus musculus	36-41
35589816-6	2022	HL-003 reduced oxidative stress in the salivary gland by regulating the expression of ROS-related proteins NOX4, SOD2, and 8-OHdG.	ros	86-89	superoxide dismutase 2, mitochondrial	Mus musculus	113-117
35441652-7	2022	Moreover, the immunohistochemistry and immunofluorescence assay results revealed that the CA markedly reduced ROS production and apoptosis, and activated antioxidant transcription factor Nrf2 in the liver.	ros	110-113	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	90-92
35628356-8	2022	These results suggested that inhibiting a vicious cycle of the ROS/STAT3/IL-6 axis by ASC-J9 may represent a potential therapeutic approach to suppress cell proliferation and ECM production in KFs.	ros	63-66	signal transducer and activator of transcription 3	Homo sapiens	67-72
35628356-8	2022	These results suggested that inhibiting a vicious cycle of the ROS/STAT3/IL-6 axis by ASC-J9 may represent a potential therapeutic approach to suppress cell proliferation and ECM production in KFs.	ros	63-66	interleukin 6	Homo sapiens	73-77
35562675-8	2022	The PTGS2/NF-kb pathway, TGF-beta/Smad signaling pathway and AGE-RAGE signaling pathway in diabetic complications may be the major signaling pathways under conditions of ROS-induced damage in TM cells.	ros	170-173	prostaglandin-endoperoxide synthase 2	Homo sapiens	4-9
35562675-8	2022	The PTGS2/NF-kb pathway, TGF-beta/Smad signaling pathway and AGE-RAGE signaling pathway in diabetic complications may be the major signaling pathways under conditions of ROS-induced damage in TM cells.	ros	170-173	renin binding protein	Homo sapiens	61-64
35562675-8	2022	The PTGS2/NF-kb pathway, TGF-beta/Smad signaling pathway and AGE-RAGE signaling pathway in diabetic complications may be the major signaling pathways under conditions of ROS-induced damage in TM cells.	ros	170-173	MOK protein kinase	Homo sapiens	65-69
35556218-7	2022	In addition, ODN decreased ROS by generating less oxidants and more antioxidants, as reflected by a dramatic increase in total antioxidant capacity, glutathione reductase, and catalase and a marked decrease in H2O2 and total nitric oxide synthase.	ros	27-30	catalase	Rattus norvegicus	176-184
35594653-5	2022	ROS activates the c-Jun N-terminal kinase (JNK) pathway to induce mitochondrial-mediated apoptosis.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	18-41
35594653-5	2022	ROS activates the c-Jun N-terminal kinase (JNK) pathway to induce mitochondrial-mediated apoptosis.	ros	0-3	mitogen-activated protein kinase 8	Homo sapiens	43-46
35563670-5	2022	Treatment with TTD decreased proliferation and induced apoptosis in Panc-1 human pancreatic cancer cells in part through the reduced expression of the Sp1-dependent anti-apoptotic gene survivin and induction of ROS-mediated endoplasmic reticulum stress, which are the well-known NR4A1-dependent proapoptotic pathways.	ros	211-214	nuclear receptor subfamily 4 group A member 1	Homo sapiens	279-284
35592531-10	2022	In addition, IL-22 can also reduce the level of mitochondrial membrane depolarization, protect mitochondria, reduce ROS production, and play a role in protecting bile ducts.	ros	116-119	interleukin 22	Rattus norvegicus	13-18
35532294-8	2022	Overexpressing miR27a (mi-miR27a) markedly promoted cellular lipid accumulation, proliferation, and invasion, accompanied by aggravated mitochondrial dysfunction (increased fading and ROS products of mitochondria) in HepG2 cells.	ros	184-187	microRNA 27a	Homo sapiens	15-21
35592099-9	2022	In the oxidative stress environment, TGF-beta3/MnO2 was superior to TGF-beta3 and MnO2 NPs in the suppression of H2O2-induced matrix degradation, ROS, and apoptosis in NPCs.	ros	146-149	transforming growth factor, beta 3	Rattus norvegicus	37-46
35615146-6	2022	Further studies revealed that AD induced ROS production to down-regulate FOXM1-ER-alpha axis.	ros	41-44	estrogen receptor 1	Homo sapiens	79-87
35615146-7	2022	Conversely, inhibiting ROS production with N-acetylcysteine (NAC) elevated AD-decreased ER-alpha expression, which could be alleviated by FOXM1 knockdown.	ros	23-26	estrogen receptor 1	Homo sapiens	88-96
35521772-12	2022	Furthermore, oleic acid treatment induced ROS production and inflammasome activation, which is manifested by enhanced caspase-1 activity and mature IL-18 protein level.	ros	42-45	caspase 1	Homo sapiens	118-127
35513484-7	2022	Present data showed that co-activation of CB1 and CB2 exerted cytotoxic effects on MDA-MB-231 cells by increasing apoptotic cell death through suppression of the NF-kappaB signaling pathway in an ROS-independent mechanism.	ros	196-199	cannabinoid receptor 1	Homo sapiens	42-45
35513484-7	2022	Present data showed that co-activation of CB1 and CB2 exerted cytotoxic effects on MDA-MB-231 cells by increasing apoptotic cell death through suppression of the NF-kappaB signaling pathway in an ROS-independent mechanism.	ros	196-199	nuclear factor kappa B subunit 1	Homo sapiens	162-171
35087226-3	2022	Unlike apoptotic cell death, activation of p53 alone is not sufficient to induce ferroptosis directly; instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS.	ros	274-277	tumor protein p53	Homo sapiens	143-146
35191133-0	2022	Glucosamine suppresses oxidative stress and induces protective autophagy in osteoblasts by blocking the ROS/Akt/mTOR signaling pathway.	ros	104-107	AKT serine/threonine kinase 1	Homo sapiens	108-111
35191133-0	2022	Glucosamine suppresses oxidative stress and induces protective autophagy in osteoblasts by blocking the ROS/Akt/mTOR signaling pathway.	ros	104-107	mechanistic target of rapamycin kinase	Homo sapiens	112-116
35544792-9	2022	Inhibition of p38, ROS, and KNL caused nuclear accumulation of Nrf2.	ros	19-22	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
35247918-4	2022	Strikingly, combinatorial treatment of inv(16)/KITD816Y AML cells with the MTH1 inhibitor TH1579 and ROS- and DNA damage-inducing standard chemotherapy induced growth arrest and incorporated oxidized nucleotides into DNA leading to significantly increased DNA damage.	ros	101-104	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	47-50
35192689-8	2022	Thus, by managing ROS levels, Nrf2 regulates beta-cell mass and is an exciting therapeutic target for expanding and protecting beta-cell mass in diabetes.	ros	18-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	30-34
35278669-7	2022	ATRA also blocked autophagic flow by activating the AKT/mTOR pathway, leading to an excessive accumulation of ROS, which further activated the NLRP3 inflammasome.	ros	110-113	AKT serine/threonine kinase 1	Homo sapiens	52-55
35278669-7	2022	ATRA also blocked autophagic flow by activating the AKT/mTOR pathway, leading to an excessive accumulation of ROS, which further activated the NLRP3 inflammasome.	ros	110-113	mechanistic target of rapamycin kinase	Homo sapiens	56-60
35278669-7	2022	ATRA also blocked autophagic flow by activating the AKT/mTOR pathway, leading to an excessive accumulation of ROS, which further activated the NLRP3 inflammasome.	ros	110-113	NLR family pyrin domain containing 3	Homo sapiens	143-148
35276443-6	2022	once) showed no effect on control mice, but inhibited completely AngII infusion-induced excess ROS production in vital organs, hypertension, aortic walls inflammation and reduced incidences of aortic aneurysm.	ros	95-98	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	65-70
35138513-5	2022	Moreover, TGF-beta increased the expression of p-Smad2/3-NOX4 in LX-2 cells and consequently increased ROS content, which is a trigger for NLRP3 inflammasome activation.	ros	103-106	NLR family pyrin domain containing 3	Homo sapiens	139-144
35471587-9	2022	H2 O2 -induced ROS production and EGFR phosphorylation decreased in NHEKs with TXNIP knockdown.	ros	15-18	thioredoxin interacting protein	Homo sapiens	79-84
35417750-9	2022	In conclusion, P. bovis induced an inflammatory response via the NF-kappaB/NLRP3 inflammasome pathway; however, scavenging ROS or activating Nrf2 mitigated the inflammatory response in infected mMECs.	ros	123-126	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	65-74
35600776-13	2022	Furthermore, over-activation of STAT3 or removal of ROS diminished the anti-proliferative effects of Rg3-plus-ART, and removal of ROS diminished Rg3-plus-ART"s inhibitory effects on STAT3 activation in HepG2-SR cells.	ros	130-133	signal transducer and activator of transcription 3	Mus musculus	182-187
35600776-14	2022	Conclusions: Rg3-plus-ART overcomes sorafenib resistance in experimental models, and inhibition of Src/STAT3 signaling and modulation of ROS/STAT3 signaling contribute to the underlying mechanisms.	ros	137-140	signal transducer and activator of transcription 3	Mus musculus	141-146
35024788-5	2022	Our data first suggest that BER itself (25 nM) does not affect embryo quality or future developmental potency, moreover, it can effectively alleviate LPS-induced embryonic damage by mitigating apoptosis via ROS-/caspase-3-dependent pathways and by suppressing pro-inflammatory cytokines via inhibition of NF-kappaB signaling pathway during preimplantation embryo development.	ros	207-210	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	305-314
35139422-4	2022	TGF-beta1 treatment increased both intra- and extracellular ROS generation along with NOX4 expression and reduced GPX and catalase activities, extracellular H2O2 scavenging capacity, and reduced thiol content.	ros	60-63	transforming growth factor, beta 1	Rattus norvegicus	0-9
35624699-12	2022	The TNF-alpha-induced NF-kappaB activation via c-Src-driven ROS was independent from the EGFR signaling pathway.	ros	60-63	tumor necrosis factor	Rattus norvegicus	4-13
35498125-0	2022	Attenuation of ROS/Chloride Efflux-Mediated NLRP3 Inflammasome Activation Contributes to Alleviation of Diabetic Cardiomyopathy in Rats after Sleeve Gastrectomy.	ros	15-18	NLR family, pyrin domain containing 3	Rattus norvegicus	44-49
35498125-12	2022	Using a ROS scavenger or chloride channel blocker in vitro restored myocardial NLRP3-mediated pyroptosis.	ros	8-11	NLR family, pyrin domain containing 3	Rattus norvegicus	79-84
35471238-2	2022	Recent developments in the studies of drug resistance have identified compounds such as verapamil and tamoxifen that specifically target ABCB1-expressing multidrug resistant (MDR) cells, through an ATP-dependent ROS-generating mechanism.	ros	212-215	ATP binding cassette subfamily B member 1	Homo sapiens	137-142
35460571-6	2022	Cytokines, such as TNF-alpha, INF-gamma, IL-6, and IL-13, were upregulated in infected cells sparking mitochondrial ROS production and change in electron transport chain complexes.	ros	116-119	tumor necrosis factor	Homo sapiens	19-28
35460571-6	2022	Cytokines, such as TNF-alpha, INF-gamma, IL-6, and IL-13, were upregulated in infected cells sparking mitochondrial ROS production and change in electron transport chain complexes.	ros	116-119	interleukin 6	Homo sapiens	41-45
35460571-6	2022	Cytokines, such as TNF-alpha, INF-gamma, IL-6, and IL-13, were upregulated in infected cells sparking mitochondrial ROS production and change in electron transport chain complexes.	ros	116-119	interleukin 13	Homo sapiens	51-56
35530176-3	2022	Microglia plays a dual role in AD, a protective role by clearing the deposits of amyloid beta peptides increasing the phagocytic response (CD163, IGF-1 or BDNF) and a cytotoxic role, releasing free radicals (ROS or NO) and proinflammatory cytokines (TNF-alpha, IL-1beta) in response to reactive gliosis activated by the amyloid beta aggregates.	ros	208-211	amyloid beta precursor protein	Homo sapiens	81-93
35139422-7	2022	Our data suggest that higher levels of TGF-beta1 in females are potentially related to higher ROS availability which may be associated with the sex disparity in thyroid disorders.	ros	94-97	transforming growth factor, beta 1	Rattus norvegicus	39-48
35455979-5	2022	Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-kappaB; as well as oncogenes, namely RAS and MYC.	ros	78-81	tumor necrosis factor	Mus musculus	149-152
35114314-5	2022	The level of methionine (Met) was not significantly changed, but NaHSO3 promoted ROS-mediated NF-kappaB signaling pathway, and increased the expressions of proinflammatory cytokines by regulating the levels of Hcy and Cys in NCM460 cells.	ros	81-84	nuclear factor kappa B subunit 1	Homo sapiens	94-103
35455979-5	2022	Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-kappaB; as well as oncogenes, namely RAS and MYC.	ros	78-81	interleukin 6	Mus musculus	159-162
35450413-6	2022	In vitro studies further uncovered that chondrocytes cocultured with BMSCs in the direct contact coculture system upregulated Kindlin-2 expression and subsequently activated the PI3K/AKT signaling pathway, which not only increases Sox9 and Col2 expression but also restores mitochondrial membrane potential and reduces ROS levels and apoptosis under inflammatory conditions.	ros	319-322	FERM domain containing kindlin 2	Homo sapiens	126-135
35412176-0	2022	Duvira Antarctic polysaccharide inhibited H1N1 influenza virus-induced apoptosis through ROS mediated ERK and STAT-3 signaling pathway.	ros	89-92	mitogen-activated protein kinase 1	Homo sapiens	102-105
35412176-0	2022	Duvira Antarctic polysaccharide inhibited H1N1 influenza virus-induced apoptosis through ROS mediated ERK and STAT-3 signaling pathway.	ros	89-92	signal transducer and activator of transcription 3	Homo sapiens	110-116
35450413-6	2022	In vitro studies further uncovered that chondrocytes cocultured with BMSCs in the direct contact coculture system upregulated Kindlin-2 expression and subsequently activated the PI3K/AKT signaling pathway, which not only increases Sox9 and Col2 expression but also restores mitochondrial membrane potential and reduces ROS levels and apoptosis under inflammatory conditions.	ros	319-322	AKT serine/threonine kinase 1	Homo sapiens	183-186
35541901-11	2022	Diminishing MAM integrity by GRP75-deficiency reduced ER-to-mitochondria Ca2+ transfer, accelerated CP-induced mitochondrial dysfunction, provoked catastrophic ROS, and enhanced CP-triggered apoptotic cell death in OC cells.	ros	160-163	heat shock protein family A (Hsp70) member 9	Homo sapiens	29-34
35541901-13	2022	Conclusion: GRP75-overexpression confers CP-resistance by distinctively managing MAM-facilitated Ca2+ fluxes and the pro-survival ROS signal, whereas GRP75-deficiency induces cell death via bioenergetic crisis and apoptotic ROS accumulation in OC cells.	ros	224-227	heat shock protein family A (Hsp70) member 9	Homo sapiens	12-17
35541901-13	2022	Conclusion: GRP75-overexpression confers CP-resistance by distinctively managing MAM-facilitated Ca2+ fluxes and the pro-survival ROS signal, whereas GRP75-deficiency induces cell death via bioenergetic crisis and apoptotic ROS accumulation in OC cells.	ros	224-227	heat shock protein family A (Hsp70) member 9	Homo sapiens	150-155
35541901-13	2022	Conclusion: GRP75-overexpression confers CP-resistance by distinctively managing MAM-facilitated Ca2+ fluxes and the pro-survival ROS signal, whereas GRP75-deficiency induces cell death via bioenergetic crisis and apoptotic ROS accumulation in OC cells.	ros	130-133	heat shock protein family A (Hsp70) member 9	Homo sapiens	12-17
35474765-6	2022	Additionally, treatment with NCA resulted in an increased level of total ROS in both cell types (HCT116 and CHEK2-null HCT116 cells), which further confirms that inhibition of PRDX2 results in an increased ROS level, which are mainly responsible for DNA double-strand breaks (DSBs).	ros	73-76	peroxiredoxin 2	Homo sapiens	176-181
35397613-11	2022	Furthermore, we confirmed that CYGB plays a role in clearing excess ROS induced by bortezomib to inhibit HNSCC apoptosis.	ros	68-71	cytoglobin	Homo sapiens	31-35
35397526-5	2022	Proliferation, CXCR4/SDF-1alpha axis activity and intracellular ROS production of CD34+ HSPC were evaluated.	ros	64-67	CD34 molecule	Homo sapiens	82-86
35392889-14	2022	In addition, ET-1 stimulation led to significant increases in ROS production that were sensitive to S. jambos.	ros	62-65	endothelin 1	Homo sapiens	13-17
35464414-10	2022	To sum up, macrophage pyroptosis is an upstream event of silica-induced pulmonary inflammation promoted by ROS through the TLR4/NLRP3/NF-kappaB signaling axis.	ros	107-110	toll-like receptor 4	Mus musculus	123-127
35464414-10	2022	To sum up, macrophage pyroptosis is an upstream event of silica-induced pulmonary inflammation promoted by ROS through the TLR4/NLRP3/NF-kappaB signaling axis.	ros	107-110	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
35409364-8	2022	Furthermore, the suppression of hypoxia-induced IL-6 production by EGCG was mediated via the inhibition of HIF-1alpha expression and the suppression of ROS generation in BV2 cells.	ros	152-155	interleukin 6	Mus musculus	48-52
35474765-6	2022	Additionally, treatment with NCA resulted in an increased level of total ROS in both cell types (HCT116 and CHEK2-null HCT116 cells), which further confirms that inhibition of PRDX2 results in an increased ROS level, which are mainly responsible for DNA double-strand breaks (DSBs).	ros	206-209	peroxiredoxin 2	Homo sapiens	176-181
35289070-10	2022	Further, analysis of organelle structure and function in asrij KO mice revealed significant changes, namely damaged mitochondria, elevated ROS; impaired endosomal trafficking seen by increased cleaved Notch1, reduced Rab5; and reduced 26S proteasome activity.	ros	139-142	OCIA domain containing 1	Mus musculus	57-62
35156339-0	2022	Engineering ROS-Responsive Bioscaffolds for Disrupting Myeloid Cell-Driven Immunosuppressive Niche to Enhance PD-L1 Blockade-Based Postablative Immunotherapy.	ros	12-15	CD274 antigen	Mus musculus	110-115
35218740-10	2022	Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA.	ros	197-200	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
35218740-0	2022	Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells.	ros	165-168	angiotensinogen	Homo sapiens	48-62
35171697-5	2022	The NLRP3 inflammasome can be activated by multiple stimuli such as extracellular ATP, microbial toxins, ROS, mitochondria DNA or particulate matter.	ros	105-108	NLR family pyrin domain containing 3	Homo sapiens	4-9
35189109-0	2022	Crosstalk between ERO1alpha and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.	ros	87-90	ryanodine receptor 2	Homo sapiens	32-50
35218740-10	2022	Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA.	ros	197-200	interleukin 6	Homo sapiens	85-89
35218740-0	2022	Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells.	ros	165-168	interleukin 6	Homo sapiens	71-75
35218740-0	2022	Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells.	ros	165-168	signal transducer and activator of transcription 3	Homo sapiens	81-86
35218740-10	2022	Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA.	ros	197-200	signal transducer and activator of transcription 3	Homo sapiens	95-100
35218740-2	2022	Angiotensin II (Ang II) involves in AAA progression by promoting the proliferation and migration of vascular smooth muscle cells, the degradation of extracellular matrices, and the generation of ROS to lead to vascular inflammation.	ros	195-198	angiotensinogen	Homo sapiens	0-14
35218740-10	2022	Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA.	ros	197-200	angiotensinogen	Homo sapiens	136-142
35227643-0	2022	ROS-mediated activation of p38 protects hepatocellular carcinoma cells from caspase-independent death elicited by lysosomal damage.	ros	0-3	mitogen-activated protein kinase 14	Homo sapiens	27-30
35218740-2	2022	Angiotensin II (Ang II) involves in AAA progression by promoting the proliferation and migration of vascular smooth muscle cells, the degradation of extracellular matrices, and the generation of ROS to lead to vascular inflammation.	ros	195-198	angiotensinogen	Homo sapiens	16-22
35218740-6	2022	The results showed that Ang II induced inflammatory responses of HASMCs via NADPH oxidase- and mitochondria-derived ROS/NF-kappaB/IL-6/Jak2/Stat3 pathway which was attenuated by the pretreatment with CORM-2.	ros	116-119	angiotensinogen	Homo sapiens	24-30
35218740-6	2022	The results showed that Ang II induced inflammatory responses of HASMCs via NADPH oxidase- and mitochondria-derived ROS/NF-kappaB/IL-6/Jak2/Stat3 pathway which was attenuated by the pretreatment with CORM-2.	ros	116-119	nuclear factor kappa B subunit 1	Homo sapiens	120-129
35218740-6	2022	The results showed that Ang II induced inflammatory responses of HASMCs via NADPH oxidase- and mitochondria-derived ROS/NF-kappaB/IL-6/Jak2/Stat3 pathway which was attenuated by the pretreatment with CORM-2.	ros	116-119	interleukin 6	Homo sapiens	130-134
35218740-6	2022	The results showed that Ang II induced inflammatory responses of HASMCs via NADPH oxidase- and mitochondria-derived ROS/NF-kappaB/IL-6/Jak2/Stat3 pathway which was attenuated by the pretreatment with CORM-2.	ros	116-119	signal transducer and activator of transcription 3	Homo sapiens	140-145
35227643-7	2022	Indeed, a ROS-dependent activation of p38 occurs in response to lysosomal damage, promoting the recovery of lysosomal integrity.	ros	10-13	mitogen-activated protein kinase 14	Homo sapiens	38-41
35505966-0	2022	TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-kappaB pathway.	ros	74-77	NFE2 like bZIP transcription factor 2	Homo sapiens	69-73
35178859-0	2022	Radiation-induced C-reactive protein triggers apoptosis of vascular smooth muscle cells through ROS interfering with the STAT3/Ref-1 complex.	ros	96-99	C-reactive protein	Homo sapiens	18-36
35178859-0	2022	Radiation-induced C-reactive protein triggers apoptosis of vascular smooth muscle cells through ROS interfering with the STAT3/Ref-1 complex.	ros	96-99	signal transducer and activator of transcription 3	Homo sapiens	121-126
35065161-4	2022	KEY FINDINGS: IMPA-2, IMPA-5, IMPA-6, IMPA-8, and IMPA-12 markedly induced cytotoxicity by notably increased NADPH oxidase (NOX) activity, which results in the induction of ROS-mediated apoptosis in A549 lung cancer cells.	ros	173-176	inositol monophosphatase 2	Homo sapiens	14-20
35065161-6	2022	Increased ROS production by IMPAs also promotes p53 mediated cell cycle arrest through the inactivation of p38MAPK.	ros	10-13	tumor protein p53	Homo sapiens	48-51
35433874-11	2022	Inhibition of exosomes secretion with GW4869 effectively prevented excessive aortic ROS production, endothelial dysfunction, and atherosclerosis in mice with CagA+ H. pylori infection.	ros	84-87	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	158-162
34995734-14	2022	Besides, protein-protein interaction (PPI) analysis demonstrated that a network consisted of FOXM1, CCNA2, CCNB1, MYBL2, PLK1 and CDK1 might be response for DATS-induced G2/M cell cycle arrest and increased intracellular ROS.	ros	221-224	cyclin A2	Homo sapiens	100-105
35408632-6	2022	The results showed that ROS aided in preventing the occurrence of constipation by improving the gastro-intestinal transit rate and the defecation frequency in mice, and ROS significantly reduced the serum levels of vasoactive intestinal peptide (VIP).	ros	169-172	vasoactive intestinal polypeptide	Mus musculus	215-244
35408632-6	2022	The results showed that ROS aided in preventing the occurrence of constipation by improving the gastro-intestinal transit rate and the defecation frequency in mice, and ROS significantly reduced the serum levels of vasoactive intestinal peptide (VIP).	ros	169-172	vasoactive intestinal polypeptide	Mus musculus	246-249
35217429-6	2022	Sperm exposed to different concentrations of IFNgamma, IL-17A and IL-1beta, or a combination of them, for either 1 or 3 h showed significantly increased levels of mitochondrial ROS production and reduced motility and viability with respect to sperm incubated with vehicle.	ros	177-180	interferon gamma	Homo sapiens	45-53
35217429-9	2022	In conclusion, our results indicate that IFNgamma, IL-17A and IL-1beta per se impair sperm motility and decreases viability by triggering increased mitochondrial ROS production and inducing sperm apoptosis.	ros	162-165	interferon gamma	Homo sapiens	41-49
35122174-0	2022	A mutation in Arabidopsis SAL1 alters its in vitro activity against IP3 and delays developmental leaf senescence in association with lower ROS levels.	ros	139-142	SAL1 phosphatase-like protein	Arabidopsis thaliana	26-30
35122174-1	2022	KEY MESSAGE: Our manuscript is the first to find a link between activity of SAL1/OLD101 against IP3 and plant leaf senescence regulation and ROS levels assigning a potential biological role for IP3.	ros	141-144	SAL1 phosphatase-like protein	Arabidopsis thaliana	76-80
35063802-5	2022	Silencing SPCA2 expression or briefly removing extracellular Ca2+ increased mitochondrial ROS production, DNA damage and activation of the ATM/ATR-p53 axis leading to G0/G1 phase cell cycle arrest and apoptosis.	ros	90-93	ATPase secretory pathway Ca2+ transporting 2	Homo sapiens	10-15
35146899-8	2022	In addition, dissociated Zn2+ further breaks the redox balance of TME, and co-inhibits the expression of P-glycoprotein (P-gp) with generated ROS to overcome drug resistance.	ros	142-145	ATP binding cassette subfamily B member 1	Homo sapiens	105-119
35146899-8	2022	In addition, dissociated Zn2+ further breaks the redox balance of TME, and co-inhibits the expression of P-glycoprotein (P-gp) with generated ROS to overcome drug resistance.	ros	142-145	ATP binding cassette subfamily B member 1	Homo sapiens	121-125
35418871-4	2022	We have sought that MGO-induced bladder overactivity is due to activation of AGE-RAGE-reactive-oxygen species (ROS) signaling cascade, leading to Rho kinase activation.	ros	111-114	MOK protein kinase	Mus musculus	81-85
35418871-12	2022	Overall, our data indicate serum MGO accumulation elevates the AGEs levels and activates the RAGE-ROS signaling leading to Rho kinase-induced muscle sensitization, ultimately leading to detrusor overactivity.	ros	98-101	MOK protein kinase	Mus musculus	93-97
35346043-16	2022	In addition, RIP3 deficiency inhibits the secretion of inflammatory cytokines (IL-16, IL-17 and IFN-gamma) and ROS production induced by TNF-alpha.	ros	111-114	tumor necrosis factor	Homo sapiens	137-146
35346043-18	2022	In mechanism, RIP3 depression could upregulate the proportion of CD4+Foxp3+ immunosuppressive Treg cells in the spleen while suppressed TLR4/MyD88/NF-kappaB signaling pathway and ROS generation, and all these anti-inflammation factors together suppress the secretion of inflammatory cytokines and necroptosis of intestinal epithelial cells.	ros	179-182	CD4 molecule	Homo sapiens	65-68
35505966-0	2022	TAZ ameliorates the microglia-mediated inflammatory response via the Nrf2-ROS-NF-kappaB pathway.	ros	74-77	nuclear factor kappa B subunit 1	Homo sapiens	78-87
35505966-8	2022	Collectively, TAZ might ameliorate the microglia-mediated inflammatory response through the Nrf2-reactive oxygen species (ROS)-nuclear factor kappaB (NF-kappaB) pathway.	ros	122-125	NFE2 like bZIP transcription factor 2	Homo sapiens	92-96
35505966-8	2022	Collectively, TAZ might ameliorate the microglia-mediated inflammatory response through the Nrf2-reactive oxygen species (ROS)-nuclear factor kappaB (NF-kappaB) pathway.	ros	122-125	nuclear factor kappa B subunit 1	Homo sapiens	150-159
35538041-8	2022	Further experiments demonstrates that H19 regulates HEI-OC1 cell viability, ATP level, mitochondrial membrane potential, mitochondrial ROS generation, and cell apoptosis ratio via the miR-653-5p/SIRT1 axis.	ros	135-138	microRNA 653	Homo sapiens	184-191
35302183-2	2022	In this study, we aimed to identify the upstream pathway involved in ROS-mediated TNF-alpha expression.	ros	69-72	tumor necrosis factor	Homo sapiens	82-91
35331277-7	2022	L-VGCCs and RyR calcium channels were also involved in promoting the excess iron influx and triggering ER stress response, respectively, which both exert excessive ROS generation and result in the ferroptosis and inflammation in BV2 cells.	ros	164-167	ryanodine receptor 1, skeletal muscle	Mus musculus	12-15
35392289-6	2022	Oxidative stress markers (ROS, mitochondrial superoxide, and NADPH oxidase) and the activity of antioxidant enzymes (superoxide dismutase and catalase) were modulated through the activation of Nrf2 signaling.	ros	26-29	NFE2 like bZIP transcription factor 2	Homo sapiens	193-197
35300571-6	2022	Also, the study unravels the status of mitochondrial permeability transition pore (MPTP), mitochondrial mass, mitochondrial membrane potential (MMP) and mitochondrial ROS production in cells treated with individual and different combination of Pb and Abeta peptides.	ros	167-170	amyloid beta precursor protein	Homo sapiens	251-256
35302183-0	2022	Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-alpha expression in hydroquinone-treated leukemia cells.	ros	78-81	microRNA 25	Homo sapiens	24-30
35307768-11	2022	EGR1 was reported to be involved in oxidative stress and cardiac hypertrophy, and NR1D1 played an important regulatory role in regulating inflammatory responses and reducing ROS production.	ros	174-177	nuclear receptor subfamily 1, group D, member 1	Rattus norvegicus	82-87
35402865-2	2022	Here we show that intracellular Ca2+ ((Ca2+)i) and ROS signals generated by high glucose and cytokine-induced ER stress activate calcineurin (CN)/NFATc2 and PI3K/AKT to maintain beta-cell identity and function.	ros	51-54	AKT serine/threonine kinase 1	Homo sapiens	162-165
35302183-0	2022	Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-alpha expression in hydroquinone-treated leukemia cells.	ros	78-81	sirtuin 3	Homo sapiens	49-54
35302183-9	2022	Inhibition of NOX4 or SIRT3 overexpression abolished HQ-induced ROS production, thereby abolishing TNF-alpha upregulation.	ros	64-67	sirtuin 3	Homo sapiens	22-27
35302183-0	2022	Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-alpha expression in hydroquinone-treated leukemia cells.	ros	78-81	tumor necrosis factor	Homo sapiens	91-100
35302183-10	2022	Overall, these results indicate that SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-alpha upregulation in HQ-treated U937 cells.	ros	121-124	microRNA 25	Homo sapiens	57-63
35302183-10	2022	Overall, these results indicate that SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-alpha upregulation in HQ-treated U937 cells.	ros	121-124	sirtuin 3	Homo sapiens	82-87
35302183-10	2022	Overall, these results indicate that SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-alpha upregulation in HQ-treated U937 cells.	ros	121-124	tumor necrosis factor	Homo sapiens	134-143
35303882-10	2022	Functionally, re-expression of ERRalpha sustains cell proliferation by regulating ROS detoxification process.	ros	82-85	estrogen related receptor alpha	Homo sapiens	31-39
35370642-9	2022	Experimental results found that SSD suppressed IL-1beta-induced differentiated ATDC 5 chondrocytes apoptosis via the Nrf2/HO-1/ROS axis in vitro.	ros	127-130	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
35372370-0	2022	Tcap Deficiency in Zebrafish Leads to ROS Production and Mitophagy, and Idebenone Improves its Phenotypes.	ros	38-41	titin-cap (telethonin)	Danio rerio	0-4
35370642-9	2022	Experimental results found that SSD suppressed IL-1beta-induced differentiated ATDC 5 chondrocytes apoptosis via the Nrf2/HO-1/ROS axis in vitro.	ros	127-130	heme oxygenase 1	Mus musculus	122-126
35301296-3	2022	While the canonical function of STING is to detect cytosolic DNA and activate inflammatory responses, HRV infection triggers the release of STIM1-bound STING in the ER by lowering Ca2+, thereby allowing STING to interact with phosphatidylinositol 4-phosphate (PI4P) and traffic to ROs to facilitates viral replication and transmission via autophagy.	ros	281-284	stromal interaction molecule 1	Homo sapiens	140-145
35093305-9	2022	In addition, the in vitro and in vivo experiments showed that ZEB1/MCT4 in synergy promoted the growth of breast cancer through ROS generation and autophagy, which can be reversed by a MCT4 inhibitor, 7ACC1.	ros	128-131	zinc finger E-box binding homeobox 1	Mus musculus	62-66
35093305-10	2022	CONCLUSION: ZEB1 directly binds to E-box elements of MCT4 promoter and enhance MCT4 expression, inducing ROS accumulation, which cooperatively resulting in breast cancer growth and shorten survival.	ros	105-108	zinc finger E-box binding homeobox 1	Mus musculus	12-16
35074406-0	2022	HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis.	ros	81-84	tumor protein p53	Homo sapiens	96-99
35074406-8	2022	Overexpression of HIWI2 in HT1080 cells causes DNA damage by increasing intracellular ROS by inhibiting the expression of antioxidant genes (SOD1, SOD2, GPX1, GPX4, and CAT).	ros	86-89	superoxide dismutase 1	Homo sapiens	141-145
35074406-8	2022	Overexpression of HIWI2 in HT1080 cells causes DNA damage by increasing intracellular ROS by inhibiting the expression of antioxidant genes (SOD1, SOD2, GPX1, GPX4, and CAT).	ros	86-89	catalase	Homo sapiens	169-172
35074406-11	2022	SIGNIFICANCE: These results are the first to show that HIWI2 acts as a tumor suppressor in fibrosarcoma by modulating the ROS/DNA damage/p53 pathway.	ros	122-125	tumor protein p53	Homo sapiens	137-140
35288651-6	2022	PPARalpha is required and sufficient to induce the pro-inflammatory cytokines and cellular ROS, which are essential for bacterial clearance and immunity, whereas PPARgamma-agonism blunts these responses, delays microbial clearance; balanced dual agonism achieved controlled inflammation while protecting the gut barrier and "reversal" of the transcriptomic network.	ros	91-94	peroxisome proliferator activated receptor alpha	Mus musculus	0-9
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	105-108	NLR family pyrin domain containing 3	Homo sapiens	39-44
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	105-108	NFE2 like bZIP transcription factor 2	Homo sapiens	196-200
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	255-258	NFE2 like bZIP transcription factor 2	Homo sapiens	196-200
35399855-5	2022	The Ce6 loading rate in the anti-EpCAM-UCNPs-Ce6 nanoparticles was about 2.9%, thereby resulting in good ROS generation ability.	ros	105-108	epithelial cell adhesion molecule	Homo sapiens	33-38
35277473-8	2022	In vitro infection of T cells induced cell death that is likely in mitochondria ROS-HIF-1a-dependent pathways.	ros	80-83	hypoxia inducible factor 1 subunit alpha	Homo sapiens	84-90
35387175-7	2022	The CAT catalyzes the endogenous H2O2 into O2 to relieve the hypoxic microenvironment, and the released HA-HMME exhibits a higher ROS generation ability, greatly boosting SDT for the inhibition of tumor growth.	ros	130-133	catalase	Homo sapiens	4-7
35258392-6	2022	Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.Abbreviations: AMPK: AMP-activated protein kinase; AOX: alternative oxidase; Baf A: bafilomycin A1; CI, respiratory complexes I; DCF-DA: 2",7"-dichlordihydrofluorescein diacetate; DHE: dihydroethidium; DSS: dextran sodium sulfate; DeltaPsimi: mitochondrial inner membrane potential; EdU: 5-ethynyl-2"-deoxyuridine; ETC: electron transport chain; FA: formaldehyde; HUVEC; human umbilical cord endothelial cells; IBD: inflammatory bowel disease; LC3B: microtubule associated protein 1 light chain 3 beta; LPS: lipopolysaccharide; MEFs: mouse embryonic fibroblasts; MTORC1: mechanistic target of rapamycin kinase complex 1; mtDNA: mitochondrial DNA; NAC: N-acetyl cysteine; OXPHOS: oxidative phosphorylation; PCs: proliferating cells; PE: phosphatidylethanolamine; PEITC: phenethyl isothiocyanate; QCs: quiescent cells; ROS: reactive oxygen species; PLA2: phospholipase A2, WB: western blot.	ros	126-129	origin recognition complex, subunit 1	Mus musculus	806-812
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	16-19	autophagy related 7	Mus musculus	79-83
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	24-27	autophagy related 7	Mus musculus	79-83
35195326-7	2022	Either legumain downregulation or aging alone induces the activation of nuclear transcription factors EB (TFEB) while it fails to further upregulate in the elderly legumain-knockdown tubules, accompanied with impaired mitophagy and increased mitochondrial ROS (mtROS) accumulation.	ros	256-259	legumain	Mus musculus	164-172
35235096-5	2022	In a further study with a palmitic acid (PA)-induced lipotoxic cell model established in H9C2 cells, we revealed that the cytosolic mtDNA was the result of PA-induced overproduction of mitochondrial ROS, which also led to the activation of the cGAS/STING system and its downstream targets.	ros	199-202	cyclic GMP-AMP synthase	Mus musculus	244-248
35134528-4	2022	Overexpressing the mitogen-activated protein kinase Hog1 upregulated by flocculation led to reduced ROS accumulation and increased glutathione peroxidase activity, leading to improved ethanol production under stress.	ros	100-103	mitogen-activated protein kinase HOG1	Saccharomyces cerevisiae S288C	52-56
35045368-6	2022	Importantly, Nrf2 knockdown attenuated the inhibition effects of D-6 on oxLDL-induced apoptosis, ROS production and NF-kappaB nuclear translocation.	ros	97-100	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
35263214-10	2022	The expression level of IL-1beta and IL-18 was promoted as the aggravation of hypoxia, accompanied by the elevated production of LDH and ROS.	ros	137-140	interleukin 1 alpha	Rattus norvegicus	24-32
35074716-12	2022	The TNFalpha induced inflammation is dependent on downstream signaling modules like PI3K, JNK and ROS.	ros	98-101	tumor necrosis factor	Homo sapiens	4-12
35219847-0	2022	Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.	ros	67-70	NLR family pyrin domain containing 3	Homo sapiens	71-76
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	nuclear factor, erythroid derived 2, like 2	Mus musculus	215-219
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	220-229
35219847-0	2022	Silica nanoparticles induce pyroptosis and cardiac hypertrophy via ROS/NLRP3/Caspase-1 pathway.	ros	67-70	caspase 1	Homo sapiens	77-86
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	toll-like receptor 4	Mus musculus	234-238
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	TNF receptor-associated factor 6	Mus musculus	239-244
35227235-4	2022	The SAT1 activation is closely related to ferroptosis upon ROS induction due to the upregulation of arachidonate 15-lipoxygenase (ALOX15) expression.	ros	59-62	arachidonate 15-lipoxygenase	Homo sapiens	100-128
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	245-254
35023144-0	2022	ROS-NLRP3 signaling pathway induces sterile inflammation after thulium laser resection of the prostate.	ros	0-3	NLR family pyrin domain containing 3	Homo sapiens	4-9
35023144-2	2022	This study mainly focuses on the role of the reactive oxygen species-NLR family, pyrin domain-containing 3 (ROS-NLRP3) signaling pathway in SI after thulium laser resection of the prostate (TmLRP).	ros	108-111	NLR family pyrin domain containing 3	Homo sapiens	112-117
35023144-9	2022	After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC.	ros	141-144	NLR family pyrin domain containing 3	Homo sapiens	48-53
35023144-9	2022	After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC.	ros	141-144	caspase 1	Homo sapiens	55-64
35023144-12	2022	Activation of the ROS-NLRP3 signaling pathway induces SI in the wound after prostatectomy.	ros	18-21	NLR family pyrin domain containing 3	Homo sapiens	22-27
35227235-4	2022	The SAT1 activation is closely related to ferroptosis upon ROS induction due to the upregulation of arachidonate 15-lipoxygenase (ALOX15) expression.	ros	59-62	arachidonate 15-lipoxygenase	Homo sapiens	130-136
35210368-5	2022	In this study, using human bronchial/lung epithelial cells and keratinocytes, we demonstrate that PKC activity is increased by transient or chronic Cr(VI) exposure, which plays no role in the activation of Src/Ras signaling and ROS upregulation by this metal toxin.	ros	228-231	proline rich transmembrane protein 2	Homo sapiens	98-101
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	ros	130-133	interferon lambda 3	Mus musculus	52-58
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	ros	130-133	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	ros	116-119	interferon lambda 3	Mus musculus	68-74
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	ros	116-119	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	120-129
35196483-4	2022	The ROS-dependent TRAF6-mediated non-proteolytic, K48/63-linked ubiquitination of ATG9A enhances its association with Beclin 1 and the assembly of VPS34-UVRAG complex, thereby stimulating autophagy.	ros	4-7	UV radiation resistance associated	Homo sapiens	153-158
35201659-2	2022	Nuclear factor erythroid-2-related factor 2 (NRF2) is a transcription factor that has a major role in protection from ROS-induced apoptosis.	ros	118-121	NFE2 like bZIP transcription factor 2	Homo sapiens	0-43
35201659-2	2022	Nuclear factor erythroid-2-related factor 2 (NRF2) is a transcription factor that has a major role in protection from ROS-induced apoptosis.	ros	118-121	NFE2 like bZIP transcription factor 2	Homo sapiens	45-49
35269405-8	2022	Following alpha-PD-L1 treatment, NDN displayed increased ROS production and increased cytotoxicity toward tumor cells but decreased degranulation.	ros	57-60	CD274 antigen	Mus musculus	16-21
35326089-5	2022	Chemotherapeutics such as BRAF and MEK inhibitors promote oxidative stress, but high ROS/RNS amounts with a robust antioxidant system allow cells to be adaptive and cooperate to non-toxic levels.	ros	85-88	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	26-30
35237380-4	2022	Our data revealed that DpdtbA (2,2"-di-pyridineketone hydrazone dithiocarbamate butyric acid ester) resisted TGF-beta1-induced EMT in gastric cancer lines (SGC-7901 and MGC-823) through ferritinophagy-mediated ROS production.	ros	210-213	transforming growth factor beta 1	Homo sapiens	109-118
35326089-5	2022	Chemotherapeutics such as BRAF and MEK inhibitors promote oxidative stress, but high ROS/RNS amounts with a robust antioxidant system allow cells to be adaptive and cooperate to non-toxic levels.	ros	85-88	mitogen-activated protein kinase kinase 7	Homo sapiens	35-38
35273919-7	2022	The ROS generation and RhoA activation were substantially enhanced in cells overexpressing SNTA1 and p66Shc, promoting proliferation and migration in these cells.	ros	4-7	syntrophin alpha 1	Homo sapiens	91-96
35190902-12	2022	In addition, ROS generation and autophagic activity during VIC calcification were also regulated by miR-22/CAB39 pathway.	ros	13-16	microRNA 22	Homo sapiens	100-106
35185151-0	2022	Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma.	ros	27-30	mitogen-activated protein kinase 1	Homo sapiens	68-71
35185151-0	2022	Liposomal Honokiol induces ROS-mediated apoptosis via regulation of ERK/p38-MAPK signaling and autophagic inhibition in human medulloblastoma.	ros	27-30	mitogen-activated protein kinase 14	Homo sapiens	72-75
35205169-2	2022	Miconazole is an azole antifungal that stimulates the expression of antioxidant enzymes via Nrf2 activation, which consequently inhibits ROS formation and NF-kappaB activation.	ros	137-140	NFE2 like bZIP transcription factor 2	Rattus norvegicus	92-96
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	ros	4-7	tumor protein p53	Homo sapiens	192-195
35215995-9	2022	The ROS scavenger N-acetyl-l-cysteine (NAC) and the p53 specific inhibitor Pifithrin-alpha (PFT-alpha) suppressed PEDV-induced apoptosis and impeded viral replication, suggesting that ROS and p53 play an important role in PEDV-induced apoptosis and viral replication.	ros	184-187	tumor protein p53	Homo sapiens	52-55
35144642-8	2022	Activated ROS-metabolism was identified in METTL7B-overexpressed LUAD cells, accompanied with upregulated protein level of GPX4, HMOX1 and SOD1 and their enzymatic activities.	ros	10-13	superoxide dismutase 1	Homo sapiens	139-143
35186183-3	2022	Ca2+ channel activation correlated with increasing NF-kappaB levels induced by ROS.	ros	79-82	nuclear factor kappa B subunit 1	Homo sapiens	51-60
35115498-7	2022	Mechanistically, Bdh1-mediated betaOHB metabolism inhibits ROS overproduction by activation of Nrf2 through enhancement of metabolic flux composed of betaOHB-AcAc-succinate-fumarate.	ros	59-62	nuclear factor, erythroid derived 2, like 2	Mus musculus	95-99
35198445-6	2022	The phosphorylation of JNK induced by IHZ-1 was reversed by the decreased ROS level.	ros	74-77	mitogen-activated protein kinase 8	Homo sapiens	23-26
35198445-8	2022	Our findings suggest that the activation of JNK by IHZ-1 treatment is dependent on the generation of ROS that mediates apoptosis and autophagy in hepatocellular carcinoma.	ros	101-104	mitogen-activated protein kinase 8	Homo sapiens	44-47
35125087-24	2022	We also found that AC-4 exhibited significant intracellular ROS production in breast cancer cells which induces apoptosis and eventually cell death.	ros	60-63	adenylate cyclase 4	Homo sapiens	19-23
35125087-30	2022	The molecule AC-4 induces ROS mediated apoptosis in breast cancer cells.	ros	26-29	adenylate cyclase 4	Homo sapiens	13-17
35132157-5	2022	When investigating the effect of inflammasome-associated proteins on neutrophils, we found that conditioned medium from UPEC-infected caspase-4 knockdown cells significantly increased phagocytosis of CFT073 and significantly decreased ROS production from neutrophils.	ros	235-238	caspase 4	Homo sapiens	134-143
35132157-6	2022	In contrast, conditioned medium from UPEC-infected NLRP3 knockdown cells significantly decreased the phagocytosis of CFT073 and significantly increased the ROS production from neutrophils.	ros	156-159	NLR family pyrin domain containing 3	Homo sapiens	51-56
35380485-0	2022	HIF-1alpha protects osteoblasts from ROS-induced apoptosis.	ros	37-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
35186974-7	2021	Moreover, HIF-1alpha-Parkin/PINK1-mediated mitophagy prevented apoptosis and ROS production in HK-2 cells subjected to HG exposure.	ros	77-80	hypoxia inducible factor 1 subunit alpha	Homo sapiens	10-20
35184409-0	2022	Myocardin-related transcription factor A drives ROS-fueled expansion of hepatic stellate cells by regulating p38-MAPK signalling.	ros	48-51	mitogen-activated protein kinase 14	Homo sapiens	109-117
35069864-8	2022	Preliminary results indicated that PCA suppressed ROS-induced senescence in NP cells via both the p16 and p53 pathways.	ros	50-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	98-101
35069864-8	2022	Preliminary results indicated that PCA suppressed ROS-induced senescence in NP cells via both the p16 and p53 pathways.	ros	50-53	tumor protein p53	Homo sapiens	106-109
35380485-9	2022	HIF-1alpha reduces H2O2-induced apoptosis by upregulating Bcl-2 and Bcl-XL, downregulating Bax, Bak, and caspase-9, stabilizing intracellular ROS levels, and promoting the repair of H2O2-induced DNA damage to reduce apoptosis.	ros	142-145	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
35573641-0	2022	Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and beta-catenin signaling pathways.	ros	83-86	mitogen-activated protein kinase 3	Homo sapiens	113-119
35039634-0	2022	ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer.	ros	0-3	inositol-trisphosphate 3-kinase B	Homo sapiens	33-38
35042627-15	2022	CONCLUSION: H2O2 increases ROS levels, which activates the ERK1/2 and p38 MAPK pathways to induce the premature senescence of melanocytes through p21 via a p53-independent pathway and consequently disrupts melanosome transfer.	ros	27-30	mitogen-activated protein kinase 3	Homo sapiens	59-65
35042627-15	2022	CONCLUSION: H2O2 increases ROS levels, which activates the ERK1/2 and p38 MAPK pathways to induce the premature senescence of melanocytes through p21 via a p53-independent pathway and consequently disrupts melanosome transfer.	ros	27-30	tumor protein p53	Homo sapiens	156-159
35138974-5	2022	Cells respond to AgNP-induced ROS generation by increasing their antioxidant pool, via NRF2 pathway activation.	ros	30-33	nuclear factor, erythroid derived 2, like 2	Mus musculus	87-91
35573641-0	2022	Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and beta-catenin signaling pathways.	ros	83-86	AKT serine/threonine kinase 1	Homo sapiens	103-106
35573641-0	2022	Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and beta-catenin signaling pathways.	ros	83-86	mechanistic target of rapamycin kinase	Homo sapiens	107-111
35039634-5	2022	Mechanistically, CAMK2G directly senses ROS, both basal and cisplatin-induced, to control the phosphorylation of ITPKB at serine 174, which directly regulates ITPKB activity to modulate cisplatin-induced ROS stress.	ros	204-207	inositol-trisphosphate 3-kinase B	Homo sapiens	113-118
35039634-5	2022	Mechanistically, CAMK2G directly senses ROS, both basal and cisplatin-induced, to control the phosphorylation of ITPKB at serine 174, which directly regulates ITPKB activity to modulate cisplatin-induced ROS stress.	ros	204-207	inositol-trisphosphate 3-kinase B	Homo sapiens	159-164
35039634-8	2022	This study reveals a key kinase network consisting of CAMK2G and ITPKB for ROS sense and scavenging in ovarian cancer cells to maintain redox homeostasis, offering a potential strategy for cisplatin resistance treatment.	ros	75-78	inositol-trisphosphate 3-kinase B	Homo sapiens	65-70
35039634-5	2022	Mechanistically, CAMK2G directly senses ROS, both basal and cisplatin-induced, to control the phosphorylation of ITPKB at serine 174, which directly regulates ITPKB activity to modulate cisplatin-induced ROS stress.	ros	40-43	inositol-trisphosphate 3-kinase B	Homo sapiens	113-118
35039634-5	2022	Mechanistically, CAMK2G directly senses ROS, both basal and cisplatin-induced, to control the phosphorylation of ITPKB at serine 174, which directly regulates ITPKB activity to modulate cisplatin-induced ROS stress.	ros	40-43	inositol-trisphosphate 3-kinase B	Homo sapiens	159-164
35100653-6	2022	The binding resulted in the generation of ROS, which consequently activated the oxidative stress-related cell cycle arrest and apoptotic pathways, viz., JNK/p38, p21Cip1/Chk1, and p21Cip1/Rb/E2F, as shown by microarray profiling.	ros	42-45	mitogen-activated protein kinase 8	Homo sapiens	153-156
35100653-6	2022	The binding resulted in the generation of ROS, which consequently activated the oxidative stress-related cell cycle arrest and apoptotic pathways, viz., JNK/p38, p21Cip1/Chk1, and p21Cip1/Rb/E2F, as shown by microarray profiling.	ros	42-45	mitogen-activated protein kinase 14	Homo sapiens	157-160
35100653-6	2022	The binding resulted in the generation of ROS, which consequently activated the oxidative stress-related cell cycle arrest and apoptotic pathways, viz., JNK/p38, p21Cip1/Chk1, and p21Cip1/Rb/E2F, as shown by microarray profiling.	ros	42-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	162-169
35100653-6	2022	The binding resulted in the generation of ROS, which consequently activated the oxidative stress-related cell cycle arrest and apoptotic pathways, viz., JNK/p38, p21Cip1/Chk1, and p21Cip1/Rb/E2F, as shown by microarray profiling.	ros	42-45	checkpoint kinase 1	Homo sapiens	170-174
35100653-6	2022	The binding resulted in the generation of ROS, which consequently activated the oxidative stress-related cell cycle arrest and apoptotic pathways, viz., JNK/p38, p21Cip1/Chk1, and p21Cip1/Rb/E2F, as shown by microarray profiling.	ros	42-45	cyclin dependent kinase inhibitor 1A	Homo sapiens	180-187
35101076-3	2022	METHODS: The effects of TRPM7 silencing on transcriptome profile, glucose uptake, lactic acid production, extracellular acidification rate (ECAR), oxygen consumption rate (OCR), intracellular ROS and ATP levels, and NAD+/NADH ratios in ovarian cancer cells were examined.	ros	192-195	transient receptor potential cation channel, subfamily M, member 7	Mus musculus	24-29
35140793-6	2022	Keap1 siRNA increased Nrf2 nuclear translocation, NQO1 mRNA transcription, and protein expression and prevented ROS generation and formation of JC-1 monomers.	ros	112-115	kelch like ECH associated protein 1	Homo sapiens	0-5
35090371-0	2022	Negative feedback system to maintain cell ROS homeostasis KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy.	ros	42-45	kelch like ECH associated protein 1	Homo sapiens	58-63
35098371-6	2022	Moreover, ATP-induced cytosolic ROS production was lower in Parp-1-/- BMDM, resulting in the decreased inflammasome complex assembly.	ros	32-35	poly(ADP-ribose) polymerase 1	Homo sapiens	60-66
35098371-9	2022	Overall, PARP-1 positively regulates NLRP3 inflammasome activation via increasing ROS production and interaction with TXNIP and NLRP3, leading to PARylation of NLRP3.	ros	82-85	poly(ADP-ribose) polymerase 1	Homo sapiens	9-15
35098371-9	2022	Overall, PARP-1 positively regulates NLRP3 inflammasome activation via increasing ROS production and interaction with TXNIP and NLRP3, leading to PARylation of NLRP3.	ros	82-85	NLR family pyrin domain containing 3	Homo sapiens	37-42
35098371-9	2022	Overall, PARP-1 positively regulates NLRP3 inflammasome activation via increasing ROS production and interaction with TXNIP and NLRP3, leading to PARylation of NLRP3.	ros	82-85	NLR family pyrin domain containing 3	Homo sapiens	160-165
35094204-9	2022	CONCLUSION: Txnrd3 overexpression leads to intracellular calcium outflow and increased ROS, which eventually leads to necrosis and focal death of colon cancer cells, while causing Txnrd3-/- mice depth of the crypt deeper, weakened intestinal secretion and immune function and aggravate the occurrence of ulcerative colitis.	ros	87-90	thioredoxin reductase 3	Mus musculus	12-18
35127942-9	2022	Furthermore, FBLN1 inhibition facilitated EESC death by triggering ferroptosis, as evidenced by increased Fe2+, lipid ROS, and malondialdehyde (MDA) level and decreased glutathione peroxidase 4 (GPX4) expression and glutathione (GSH) level.	ros	118-121	fibulin 1	Homo sapiens	13-18
35154136-0	2022	Role of ROS-Induced NLRP3 Inflammasome Activation in the Formation of Calcium Oxalate Nephrolithiasis.	ros	8-11	NLR family pyrin domain containing 3	Homo sapiens	20-25
35090371-0	2022	Negative feedback system to maintain cell ROS homeostasis KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy.	ros	111-114	kelch like ECH associated protein 1	Homo sapiens	58-63
35204104-8	2022	UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK.	ros	12-15	AKT serine/threonine kinase 1	Homo sapiens	36-39
35204109-4	2022	Peroxiredoxin 6 (PRDX6) possesses peroxidase and Ca2+-independent-phospholipase-A2 (iPLA2) activities that scavenge ROS and repair oxidized sperm membranes, respectively.	ros	116-119	phospholipase A2, group VI	Mus musculus	49-82
35204109-4	2022	Peroxiredoxin 6 (PRDX6) possesses peroxidase and Ca2+-independent-phospholipase-A2 (iPLA2) activities that scavenge ROS and repair oxidized sperm membranes, respectively.	ros	116-119	phospholipase A2, group VI	Mus musculus	84-89
35204104-8	2022	UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK.	ros	12-15	mitogen-activated protein kinase 14	Homo sapiens	106-109
35204104-8	2022	UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK.	ros	12-15	mitogen-activated protein kinase 1	Homo sapiens	111-114
35204104-8	2022	UVB-induced ROS production mediated Akt and mitogen activated protein kinases (MAPKs) pathways, including p38, ERK, and JNK.	ros	12-15	mitogen-activated protein kinase 8	Homo sapiens	120-123
35065654-13	2022	Moreover, the testicular ZIP12 expression levels significantly decreased in obese mice, which was associated with reduced sperm zinc content, excessive sperm ROS generation, poor sperm quality and male subfertility.	ros	158-161	solute carrier family 39 (zinc transporter), member 12	Mus musculus	25-30
35204084-5	2022	Oxidative stress and inflammation were curtailed by affecting three main pathways: (1) inhibition of cyclooxygenase-2 enzyme and consequent decrease of signaling generating ROS; (2) increased synthesis of glutathione and therefore strengthening of the natural antioxidant defenses of the cells; (3) decreased infection-driven mitochondrial respiratory burst which generates oxidative stress.	ros	173-176	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-117
35058429-8	2022	Specifically, Pex3-/- mice produced elevated amounts of ROS, which damaged germ cell DNA and further activated the signaling pathway of the cell senescence regulatory protein P16-CDK6, resulting in cell cycle arrest and eventually contributing to spermatogenesis dysfunction.	ros	56-59	cyclin dependent kinase inhibitor 2A	Mus musculus	175-178
35159424-5	2022	Pretreatment with flavonoids-rich PCR-C samples (particularly PCR-C10) considerably reversed t-BHP-induced oxidative damage in HepG2 cells by improving cell viability, increasing SOD activity and GSH levels and reducing the overproduction of ROS and MDA.	ros	242-245	homeobox C10	Homo sapiens	66-69
35163154-9	2022	Increased expression of Nrf2 target genes led to reduced ROS production.	ros	57-60	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
35416273-12	2022	MiR-384-5p downregulation mitigated ketamine-induced neurotoxicity by restraining apoptosis and ROS activity in neurons.	ros	96-99	microRNA 384	Homo sapiens	0-7
35043976-5	2022	Such improved immunotherapy response by MCT4 targeting was due to combined consequences, characterized by the alleviated acidification of tumor microenvironment (TME) and elevated the CXCL9/CXCL10 secretion induced by ROS/NF-kappaB signaling pathway.	ros	218-221	C-X-C motif chemokine ligand 9	Homo sapiens	184-189
35039048-10	2022	Mechanistically, cancer cells with reduced NOP56 are subjected to higher levels of ROS and rely on mTOR signaling to balance oxidative stress and survive.	ros	83-86	NOP56 ribonucleoprotein	Homo sapiens	43-48
35039048-9	2022	RESULTS: We demonstrated that nucleolar protein 5A (NOP56), a core component of small nucleolar ribonucleoprotein complexes (snoRNPs) with an essential role in ribosome biogenesis, confers a metabolic dependency by regulating ROS homeostasis in KRAS-mutant lung cancer cells and that NOP56 depletion causes synthetic lethal susceptibility to inhibition of mTOR.	ros	226-229	NOP56 ribonucleoprotein	Homo sapiens	52-57
34985729-8	2022	Finally, intracellular ROS production was determined using fluorescent probes (DCFH-DA).High concentrations of UA either alone or combined with LPS increased the protein levels of GRP78 and CHOP.	ros	23-26	heat shock protein family A (Hsp70) member 5	Homo sapiens	180-185
35035661-10	2022	Nrf2 knockdown significantly decreased IL1beta expression in LPS/ATP-stimulated RAW264.7 macrophages suggesting that CoQ0 inhibited ROS-mediated NLRP3 inflammasome activation and IL1beta expression was suppressed due to the Nrf2 activation.	ros	132-135	nuclear factor, erythroid derived 2, like 2	Mus musculus	224-228
35055146-7	2022	In conclusion, we demonstrate that CypD is implicated in the pathogenesis of SAE, possibly related to the inhibition of MPTP induction and, as a consequence, the decreased production of ROS and other free radicals, thereby protecting mitochondrial and cellular function.	ros	186-189	peptidylprolyl isomerase F (cyclophilin F)	Mus musculus	35-39
35052632-7	2022	Our results showed that NAP treatment prevents ROS formation by reducing UV-B-irradiation-induced apoptotic cell death and JNK signalling pathway activation.	ros	47-50	mitogen-activated protein kinase 8	Homo sapiens	123-126
34985729-8	2022	Finally, intracellular ROS production was determined using fluorescent probes (DCFH-DA).High concentrations of UA either alone or combined with LPS increased the protein levels of GRP78 and CHOP.	ros	23-26	DNA damage inducible transcript 3	Homo sapiens	190-194
35035671-16	2022	Furthermore, the effects of FA on TGF-beta1-induced increased ROS levels and alpha-SMA and COLI expression were weaken by silencing NOX4.	ros	62-65	transforming growth factor beta 1	Homo sapiens	34-43
35047402-0	2021	Dihydroartemisinin-Transferrin Adducts Enhance TRAIL-Induced Apoptosis in Triple-Negative Breast Cancer in a P53-Independent and ROS-Dependent Manner.	ros	129-132	TNF superfamily member 10	Homo sapiens	47-52
35075949-0	2022	Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/Caspase-1 signaling.	ros	63-66	NLR family, pyrin domain containing 3	Rattus norvegicus	67-72
35075949-8	2022	Taken together, our results suggest that U-treatment can trigger NRK-52E cells pyroptosis which is involvement of ROS/NLRP3/Caspase-1 pathway.	ros	114-117	NLR family, pyrin domain containing 3	Rattus norvegicus	118-123
35075949-9	2022	Targeting ROS/NLRP3/Caspase-1-mediated pyroptosis may be a novel approach for attenuating U nephrotoxicity.	ros	10-13	NLR family, pyrin domain containing 3	Rattus norvegicus	14-19
35296207-7	2022	I/R-induced upregulation of STAT3 phosphorylation and ZIP2 expression was reversed by the ROS scavenger N-acetylcysteine (NAC) and the NOX inhibitor diphenyleneiodonium (DPI).	ros	90-93	signal transducer and activator of transcription 3	Mus musculus	28-33
35184677-9	2022	In CONV-R mice stress-induced increases in colonic Duox2 and Nos2 (ROS generating enzymes) strongly paralleled changes to microbiome composition and function, evidencing Str-mediated ROS production as a primary factor mediating gut-microbiota dysbiosis.	ros	67-70	nitric oxide synthase 2, inducible	Mus musculus	61-65
35093588-12	2022	Elevated ROS in Pxdn-/- livers was observed, which can result in activation of hypoxic signaling cascades and may affect signaling pathways involved in macrophage polarization such as TNF-alpha via NF-kappaB.	ros	9-12	peroxidasin	Mus musculus	16-20
35093588-12	2022	Elevated ROS in Pxdn-/- livers was observed, which can result in activation of hypoxic signaling cascades and may affect signaling pathways involved in macrophage polarization such as TNF-alpha via NF-kappaB.	ros	9-12	tumor necrosis factor	Mus musculus	184-193
35093588-12	2022	Elevated ROS in Pxdn-/- livers was observed, which can result in activation of hypoxic signaling cascades and may affect signaling pathways involved in macrophage polarization such as TNF-alpha via NF-kappaB.	ros	9-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	198-207
35184677-9	2022	In CONV-R mice stress-induced increases in colonic Duox2 and Nos2 (ROS generating enzymes) strongly paralleled changes to microbiome composition and function, evidencing Str-mediated ROS production as a primary factor mediating gut-microbiota dysbiosis.	ros	183-186	dual oxidase 2	Mus musculus	51-56
35184677-9	2022	In CONV-R mice stress-induced increases in colonic Duox2 and Nos2 (ROS generating enzymes) strongly paralleled changes to microbiome composition and function, evidencing Str-mediated ROS production as a primary factor mediating gut-microbiota dysbiosis.	ros	183-186	nitric oxide synthase 2, inducible	Mus musculus	61-65
2645866-6	1989	In conclusion, the substitution of the specificity of tyrosine kinase of the insulin receptor with that of the v-ros oncogene product results in defective internalization and degradation of insulin, and loss of ligand-induced receptor internalization.	ros	56-59	insulin receptor	Homo sapiens	77-93
35108494-6	2021	Pretreatment of the cells with ROS scavengers or inhibitors or depleting mitochondrial DNA significantly attenuated Nano-CuO-induced MAPKs activation and MMP-3 upregulation, and pretreatment of cells with MAPKs inhibitors abolished Nano-CuO-induced MMP-3 upregulation, suggesting Nano-CuO-induced MMP-3 upregulation is through Nano-CuO-induced ROS generation and MAPKs activation.	ros	31-34	matrix metallopeptidase 3	Homo sapiens	154-159
35108494-6	2021	Pretreatment of the cells with ROS scavengers or inhibitors or depleting mitochondrial DNA significantly attenuated Nano-CuO-induced MAPKs activation and MMP-3 upregulation, and pretreatment of cells with MAPKs inhibitors abolished Nano-CuO-induced MMP-3 upregulation, suggesting Nano-CuO-induced MMP-3 upregulation is through Nano-CuO-induced ROS generation and MAPKs activation.	ros	31-34	matrix metallopeptidase 3	Homo sapiens	249-254
35108494-6	2021	Pretreatment of the cells with ROS scavengers or inhibitors or depleting mitochondrial DNA significantly attenuated Nano-CuO-induced MAPKs activation and MMP-3 upregulation, and pretreatment of cells with MAPKs inhibitors abolished Nano-CuO-induced MMP-3 upregulation, suggesting Nano-CuO-induced MMP-3 upregulation is through Nano-CuO-induced ROS generation and MAPKs activation.	ros	31-34	matrix metallopeptidase 3	Homo sapiens	297-302
35108494-9	2021	Nano-CuO exposure also caused cells to undergo EMT, which was through Nano-CuO-induced dysregulation of ROS/MAPKs/MMP-3 pathway.	ros	104-107	matrix metallopeptidase 3	Homo sapiens	114-119
2547644-8	1989	This stimulation of phosphodiesterase activity is undoubtedly related to transphosphorylation by exogenous ATP of endogenous GMP and GDP involving catalytic actions of guanylate kinase and nucleoside diphosphate kinase in isolated ROS.	ros	231-234	guanylate kinase 1	Homo sapiens	168-184
35104825-7	2022	Moreover, it suppressed Mphi infiltration into kidneys and reduced TLR9 expression in Mphis (p < 0.01), thereby lowering TNF-alpha production in CD11b high Mphis (p < 0.05) and ROS production by CD11b low Mphis (p < 0.01).	ros	177-180	integrin alpha M	Mus musculus	195-200
35341501-9	2022	Nrf2 and Ass1 can play a certain role in eliminating ROS and ammonia detoxification by increasing their expression under the oxidative damage of rat liver cells caused by PFOA.	ros	53-56	NFE2 like bZIP transcription factor 2	Rattus norvegicus	0-4
2465299-4	1989	hPTH(1-34) significantly decreased the amount of OP in culture media of the rat osteoblastic osteosarcoma cell line, ROS 17/2.8, detected by Western immunoblot analysis.	ros	117-120	secreted phosphoprotein 1	Rattus norvegicus	49-51
2836739-6	1988	Using the insulin receptor-related avian sarcoma oncogene v-ros as a probe, we have isolated and characterized the complementary DNA of a novel gene, ltk (leukocyte tyrosine kinase).	ros	60-63	insulin receptor	Mus musculus	10-26
2479640-1	1989	In rat osteosarcoma (ROS 17/2.8) cells, which express osteoblastic features in culture, basic fibroblast growth factor (bFGF) reduces the level of alkaline phosphatase, type I collagen, and osteocalcin mRNA and increases osteopontin mRNA, independent of growth stimulation.	ros	21-24	fibroblast growth factor 2	Rattus norvegicus	88-118
2455233-6	1988	Guanylate cyclase from toad ROS is strongly stimulated when the calcium level is lowered from 10 microM to 10 nM, but only if they are excited by light.	ros	28-31	guanylate cyclase	Bos taurus	0-17
2479640-1	1989	In rat osteosarcoma (ROS 17/2.8) cells, which express osteoblastic features in culture, basic fibroblast growth factor (bFGF) reduces the level of alkaline phosphatase, type I collagen, and osteocalcin mRNA and increases osteopontin mRNA, independent of growth stimulation.	ros	21-24	fibroblast growth factor 2	Rattus norvegicus	120-124
3478171-1	1987	We investigated the effects of 1,25-dihydroxyvitamin D3 on the synthesis of osteopontin, a phosphorylated cell attachment glycoprotein, in ROS 17/2.8 cells, a clonal osteoblast-like rat osteosarcoma cell line.	ros	139-142	secreted phosphoprotein 1	Rattus norvegicus	76-87
2911561-8	1989	Comparison of the exon structure of the tyrosine kinase domain of the INSR with the corresponding regions of the human SRC, ROS, and ERBB2 (NGL) protooncogenes indicates that the exon-intron organization of this region has not been well conserved.	ros	124-127	insulin receptor	Homo sapiens	70-74
2848035-2	1988	Both hPTHrp-(1-34) and [Tyr40]hPTHrp-(1-40) showed full agonist activity in stimulating cyclic AMP accumulation in ROS cells; human PTHrp-(1-34) was approximately 2.5-fold as potent as hPTH-(1-34).	ros	115-118	parathyroid hormone like hormone	Homo sapiens	5-11
2848035-2	1988	Both hPTHrp-(1-34) and [Tyr40]hPTHrp-(1-40) showed full agonist activity in stimulating cyclic AMP accumulation in ROS cells; human PTHrp-(1-34) was approximately 2.5-fold as potent as hPTH-(1-34).	ros	115-118	parathyroid hormone like hormone	Homo sapiens	30-36
2848035-2	1988	Both hPTHrp-(1-34) and [Tyr40]hPTHrp-(1-40) showed full agonist activity in stimulating cyclic AMP accumulation in ROS cells; human PTHrp-(1-34) was approximately 2.5-fold as potent as hPTH-(1-34).	ros	115-118	parathyroid hormone like hormone	Homo sapiens	6-11
2848035-4	1988	Binding to intact ROS cells of a 125I-labeled [Tyr40]hPTHrp-(1-40) (125I-[Tyr40]hPTHrp-(1-40)) which retains full biological activity was time- and temperature-dependent and reversible.	ros	18-21	parathyroid hormone like hormone	Homo sapiens	53-59
2848035-4	1988	Binding to intact ROS cells of a 125I-labeled [Tyr40]hPTHrp-(1-40) (125I-[Tyr40]hPTHrp-(1-40)) which retains full biological activity was time- and temperature-dependent and reversible.	ros	18-21	parathyroid hormone like hormone	Homo sapiens	80-86
2848035-6	1988	The binding capacity and affinity of receptors in ROS cells were strikingly similar for hPTHrp and PTH.	ros	50-53	parathyroid hormone like hormone	Homo sapiens	88-94
2848035-8	1988	The data indicate that hPTHrp and PTH, their amino-terminal fragments at least, interact with the identical receptors with regard to affinity, capacity, specificity, and physicochemical characteristics in osteoblastic ROS 17/2.8 cells.	ros	218-221	parathyroid hormone like hormone	Homo sapiens	23-29
3166460-2	1988	Osteopontin (OP) is a recently discovered bone matrix protein which was shown to promote the attachment of osteoblastic rat osteosarcoma ROS 17/2.8 cells to their substrate.	ros	137-140	secreted phosphoprotein 1	Rattus norvegicus	0-11
3166460-2	1988	Osteopontin (OP) is a recently discovered bone matrix protein which was shown to promote the attachment of osteoblastic rat osteosarcoma ROS 17/2.8 cells to their substrate.	ros	137-140	secreted phosphoprotein 1	Rattus norvegicus	13-15
3036739-5	1987	The RCS-1 cell line was poorly tumorigenic in normal C57Bl/6 Ros mice.	ros	61-64	reticular cell sarcoma suppression 1	Mus musculus	4-9
33756232-4	2021	Here, we found that exogenous oxidative stress induced by injection of ROS -generating reagent alleviated IL-33 -triggered ILC2 response and inflammation both in the airway and in the liver.	ros	71-74	interleukin 33	Homo sapiens	106-111
33122470-0	2021	Inhibition of MUC1-C Increases ROS and Cell Death in Mouse Embryonic Stem Cells.	ros	31-34	mucin 1, transmembrane	Mus musculus	14-18
34022200-12	2021	ROS was elevated by SB for the increased ANT activity in proton leak in Neuro-2a.	ros	0-3	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5	Mus musculus	41-44
34022200-15	2021	ROS may be a factor in the ANT activation by SB.	ros	0-3	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 5	Mus musculus	27-30
34020031-0	2021	STING Attenuates ROS Induced intervertebral disc degeneration.	ros	17-20	stimulator of interferon response cGAMP interactor 1	Homo sapiens	0-5
33990669-12	2021	By gene silencing of HIF-1alpha and miR-210 the expression of PDHA1 was upregulated while that of MITF-M was downregulated, yielding acceleration of mitochondrial respiratory activity and thus elimination of ROS.	ros	208-211	microRNA 210	Homo sapiens	36-43
33990669-14	2021	Based on the results of measurements of mitochondrial resipiratory activity, ROS production, and changes in the metabolites obtained in cells under the observed conditions, we concluded that silencing of HIF-1alpha and miR-210 yields apoptosis and, ultimately, apoptotic cell death in A375 melanoma cells.	ros	77-80	microRNA 210	Homo sapiens	219-226
34004559-0	2021	Lipopolysaccharide induces vascular endothelial cell pyroptosis via the SP1/RCN2/ROS signaling pathway.	ros	81-84	reticulocalbin 2	Homo sapiens	76-80
34004559-5	2021	RCN2 knockdown resulted in a significant decrease in pyroptosis, reduced LDH and IL-1beta release and ROS production and inhibited the expression of pyroptosis-related proteins (NLRP3, cleaved caspase-1, and cleaved GSDMD) (all p < 0.05).	ros	102-105	reticulocalbin 2	Homo sapiens	0-4
34004559-10	2021	These findings suggested that the activation of the SP1/RCN2/ROS signaling pathway could promote LPS-induced endothelial cell pyroptosis.	ros	61-64	reticulocalbin 2	Homo sapiens	56-60
33436533-6	2021	Transduced Tat-Trx1 markedly inhibited intracellular ROS levels, DNA fragmentation, and cell death in H2O2-treatment HT-22 cells.	ros	53-56	tyrosine aminotransferase	Mus musculus	11-14
33555513-0	2021	Tropical lichen, Dirinaria consimilis, induces ROS-mediated activation of MAPKs and triggers caspase cascade mediated apoptosis in brain and cervical cancer cells.	ros	47-50	caspase 8	Homo sapiens	93-100
33555513-12	2021	Performed in-depth anticancer study revealed the ROS-mediated regulation of MAP kinases and activation of caspase cascade in U87 and HeLa cells upon DCME treatment.	ros	49-52	caspase 8	Homo sapiens	106-113
33760192-8	2021	Overall, the present results revealed a novel molecular mechanism whereby TPL induced lethal autophagy through the ROS-JAK2/STAT3 signaling cascade in SKOV3/DDP cells.	ros	115-118	Janus kinase 2	Homo sapiens	119-123
33601276-8	2021	In cultured colon epithelial cells, r-Alb prevented DSS- and H2O2-induced ROS elevation and barrier dysfunction, preceded by inhibition of sulfenic acid formation and P38 activation.	ros	74-77	albumin	Mus musculus	38-41
33933661-8	2021	Mitochondrial ROS generation may be responsible for the increased expression of NRF-1 induced by IH preconditioning.	ros	14-17	nuclear respiratory factor 1	Homo sapiens	80-85
33932464-0	2021	Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice.	ros	57-60	cytochrome b-245, beta polypeptide	Mus musculus	27-31
33967677-7	2021	Finally, our proteomic evaluation suggested an anti-inflammatory mechanism of Ang-(1-7) toward the ROS modulators Uchl1 and Prdx1.	ros	99-102	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	114-119
33917526-8	2021	Among all types of ROS/RNS-mediated treatments, plasma exposure exerted the most notable increase of activation markers at 24 h such as CD25, CD40, and CD83 known to be crucial for T cell costimulation.	ros	19-22	interleukin 2 receptor subunit alpha	Homo sapiens	136-140
33917526-8	2021	Among all types of ROS/RNS-mediated treatments, plasma exposure exerted the most notable increase of activation markers at 24 h such as CD25, CD40, and CD83 known to be crucial for T cell costimulation.	ros	19-22	CD40 molecule	Homo sapiens	142-146
32372191-9	2021	RESULTS: GPR120 agonist III significantly suppressed macrophage infiltration and ROS production and reversed hepatic inflammation, ER stress and apoptosis in dietary-induced steatohepatitis.	ros	81-84	free fatty acid receptor 4	Mus musculus	9-15
33868142-0	2021	Waterfall Forest Environment Regulates Chronic Stress via the NOX4/ROS/NF-kappaB Signaling Pathway.	ros	67-70	NADPH oxidase 4	Homo sapiens	62-66
33754072-0	2021	Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation.	ros	94-97	S100 calcium binding protein A9	Rattus norvegicus	30-36
33650104-4	2021	Compared with Ara h 3-raw (purified from raw peanut) group, more significant results such as the inhibited Caco-2 cell viability and proliferation, the increased secretion of ROS and the decreased transepithelial electrical resistance were obtained in Ara h 3-roasted (purified from roasted peanut) group.	ros	175-178	arachin Ahy-3-like	Arachis hypogaea	252-259
2443513-1	1987	We have reported previously that serum and alpha 2-macroglobulin (alpha 2M) induce Ca2+-activated hyperpolarizations in the membrane potential of a clonal rat osteosarcoma cell line (ROS 17/2) (Dixon and Aubin, J.	ros	183-186	alpha-2-macroglobulin	Rattus norvegicus	43-64
2443513-1	1987	We have reported previously that serum and alpha 2-macroglobulin (alpha 2M) induce Ca2+-activated hyperpolarizations in the membrane potential of a clonal rat osteosarcoma cell line (ROS 17/2) (Dixon and Aubin, J.	ros	183-186	alpha-2-macroglobulin	Rattus norvegicus	66-74
3039503-1	1987	A retrovirus containing part of the human insulin receptor (hIR) gene was constructed by replacing ros sequences in the avian sarcoma virus UR2 with hIR cDNA sequences coding for 46 amino acids of the extracellular domain and the entire transmembrane and cytoplasmic domains of the beta subunit of hIR.	ros	99-102	insulin receptor	Homo sapiens	42-58
3024151-7	1986	The ROS 17/2.8 cells attached and attained a spread morphology on surfaces coated with sialoprotein.	ros	4-7	cysteine-rich secretory protein 3	Rattus norvegicus	87-99
33785331-7	2021	In addition, our data reveal that the lack of Ucp1 results in reduced expressions of regulatory proteins involved in scavenging of ROS by enhancing an autophagic event to balance osteogenic differentiation.	ros	131-134	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	46-50
33872571-7	2021	The ox-LDL-induced mitochondrial damage indicated as the increased generation of mitochondrial ROS, decreased mitochondrial membrane potential and increased mitochondrial DNA release was abolished by RXRbeta overexpression but aggravated by RXRbeta knockdown.	ros	95-98	retinoid X receptor alpha	Mus musculus	200-207
34011928-0	2021	Alternative polyadenylation trans-factor FIP1 exacerbates UUO/IRI-induced kidney injury and contributes to AKI-CKD transition via ROS-NLRP3 axis.	ros	130-133	factor interacting with PAPOLA and CPSF1	Homo sapiens	41-45
34011928-9	2021	Finally, we proved that FIP1 silencing attenuated the inflammation activation, fibrogenesis, ROS production and apoptosis induced by UUO or IRI.	ros	93-96	factor interacting with PAPOLA and CPSF1	Homo sapiens	24-28
34019862-8	2021	Pharmacological inhibition indicated that BKA-triggered NET formation was associated with ROS-p38 and -ERK signaling pathways, but independent on NADPH oxidase.	ros	90-93	mitogen-activated protein kinase 14	Mus musculus	94-97
33992720-6	2021	Aspartame exposure to PANC-1 cells activated AKT and deactivated GSK3beta by increasing levels of ROS and cytoplasmic Ca+2, respectively, through T1R2/T1R3 stimulation.	ros	98-101	glycogen synthase kinase 3 alpha	Homo sapiens	65-73
34045966-2	2021	In this study, we mainly explore the molecular mechanism of ROS-induced CD13 expression using hepatocarcinoma cells as the research object.	ros	60-63	alanyl aminopeptidase, membrane	Homo sapiens	72-76
34045966-3	2021	We show that the drug of fluorouracil (5FU), epirubicin (EPI) and gemcitabine (GEM) can induce ROS generation, activate Ets2 and promote CD13 expression.	ros	95-98	alanyl aminopeptidase, membrane	Homo sapiens	137-141
34045966-4	2021	Meanwhile, CD13 can activate NRF1 and up-regulate ROS scavenging genes transcription, such as SOD1, GPX1, GPX2 and GPX3, leading to down-regulation of intracellular ROS level and reducing the sensitivity of cells to chemotherapy agent.	ros	50-53	alanyl aminopeptidase, membrane	Homo sapiens	11-15
34045966-4	2021	Meanwhile, CD13 can activate NRF1 and up-regulate ROS scavenging genes transcription, such as SOD1, GPX1, GPX2 and GPX3, leading to down-regulation of intracellular ROS level and reducing the sensitivity of cells to chemotherapy agent.	ros	165-168	alanyl aminopeptidase, membrane	Homo sapiens	11-15
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	NADPH oxidase 1	Homo sapiens	212-216
33898327-7	2021	Furthermore, CPT induced the generation of ROS to modulate the AMPK/mTOR/ULK1 axis to finally promote protective autophagy.	ros	43-46	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	63-67
33898327-7	2021	Furthermore, CPT induced the generation of ROS to modulate the AMPK/mTOR/ULK1 axis to finally promote protective autophagy.	ros	43-46	unc-51 like autophagy activating kinase 1	Homo sapiens	73-77
33513310-0	2021	NOX1 Promotes Mesothelial-Mesenchymal Transition Through Modulation of ROS-mediated Signaling.	ros	71-74	NADPH oxidase 1	Mus musculus	0-4
33828484-6	2021	IFN-lambda1 can increase intracellular ROS level, decrease STAT1 phosphorylation, and inhibit the colonization of S. aureus in human primary keratinocytes.	ros	39-42	interferon lambda 1	Homo sapiens	0-11
33681190-11	2021	The in vitro results showed that TGF-beta1 significantly inhibited mitochondrial ATP production rate and increased mitochondrial ROS (mtROS) production when compared to control, which was normalized by KCa3.1 gene silencing.	ros	129-132	transforming growth factor, beta 1	Mus musculus	33-42
33860081-0	2021	Impact of ETNK1 somatic mutations on phosphoethanolamine synthesis, ROS production and DNA damage.	ros	68-71	ethanolamine kinase 1	Homo sapiens	10-15
33754045-15	2021	The KEAP1-NRF2 and mTORC1-cMyc axis are independently activated upon ADSL overexpression and may favor the survival and proliferation of ROS-accumulating cells, favoring DNA damage and tumorigenesis.	ros	137-140	CREB regulated transcription coactivator 1	Mus musculus	19-25
33754045-15	2021	The KEAP1-NRF2 and mTORC1-cMyc axis are independently activated upon ADSL overexpression and may favor the survival and proliferation of ROS-accumulating cells, favoring DNA damage and tumorigenesis.	ros	137-140	adenylosuccinate lyase	Homo sapiens	69-73
33644049-1	2021	Aim: Previous research recognizes that NADPH can produce reduced glutathione (GSH) as a coenzyme and produce ROS as a substrate of NADPH oxidase (NOX).	ros	109-112	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	39-44
33644049-1	2021	Aim: Previous research recognizes that NADPH can produce reduced glutathione (GSH) as a coenzyme and produce ROS as a substrate of NADPH oxidase (NOX).	ros	109-112	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	131-136
33644049-22	2021	Conclusion: In summary, combined administration of NADPH and NOX inhibitors offers better neuroprotection by reducing NADPH as a NOX substrate to generate ROS.	ros	155-158	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	51-56
33644049-22	2021	Conclusion: In summary, combined administration of NADPH and NOX inhibitors offers better neuroprotection by reducing NADPH as a NOX substrate to generate ROS.	ros	155-158	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	118-123
33393230-6	2021	Mechanistically, OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transportation through deubiquitinating and stabilizing IREB2, leading to increased ROS generation and ferroptosis.	ros	168-171	OTU deubiquitinase 1	Homo sapiens	17-22
33393230-6	2021	Mechanistically, OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transportation through deubiquitinating and stabilizing IREB2, leading to increased ROS generation and ferroptosis.	ros	168-171	transferrin receptor	Homo sapiens	32-62
33393230-6	2021	Mechanistically, OTUD1 promotes transferrin receptor protein 1 (TFRC)-mediated iron transportation through deubiquitinating and stabilizing IREB2, leading to increased ROS generation and ferroptosis.	ros	168-171	transferrin receptor	Homo sapiens	64-68
33536069-7	2021	The obtained results demonstrated also an obvious reduction in intracellular accumulated ROS and NO, as well as mitigated ER stress through the downregulation of Chop, Perk, Atf6, Ire1, and Xbp1 transcripts upon PTP1B inhibition.	ros	89-92	LOW QUALITY PROTEIN: X-box-binding protein 1	Equus caballus	190-194
33045275-6	2021	Cellular study showed that both CsIL-10R1 and CsIL-10R2 were expressed on peripheral blood leukocytes (PBLs), and blockade of CsIL-10R1 or CsIL-10R2 by antibody could reduce inhibitory effect of CsIL-10 on ROS production of PBLs.	ros	206-209	interleukin-10	Cynoglossus semilaevis	32-39
33552977-13	2020	The increase of PCAT6 induced the accumulation of ROS, mitochondrial and metabolic dysfunction in macrophages and mimics of miR-326 exhibited an opposite process.	ros	50-53	prostate cancer associated transcript 6	Homo sapiens	16-21
33242463-5	2021	Mechanistically, tumor HIF1alpha signaling activated by chemo-induced ROS drives the transcription of HMGB1 to promote more macrophage infiltration into CRC tumor.	ros	70-73	high mobility group box 1	Homo sapiens	102-107
33099744-5	2021	The temporal and episodic increase in ROS levels (oxidative stress) heightened 8-hydroxyguanosine levels indicating oxidative damage after rMTBI that was concomitant with decline in SOD2 function.	ros	38-41	superoxide dismutase 2	Homo sapiens	182-186
2442177-1	1987	Using microelectrode techniques, we have observed that the application of serum or alpha 2-macroglobulin (alpha 2M) induces transient hyperpolarizations in the membrane potential of a rat osteosarcoma clone (ROS 17/2).	ros	208-211	alpha-2-macroglobulin	Rattus norvegicus	83-104
33440765-5	2021	This pathway is independent of CSA and likely plays a protective role against Ca2+ and ROS toxicity.	ros	87-90	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	31-34
32789757-7	2021	However, XDH is in principle also able to generate ROS.	ros	51-54	xanthine dehydrogenase	Homo sapiens	9-12
2442177-1	1987	Using microelectrode techniques, we have observed that the application of serum or alpha 2-macroglobulin (alpha 2M) induces transient hyperpolarizations in the membrane potential of a rat osteosarcoma clone (ROS 17/2).	ros	208-211	alpha-2-macroglobulin	Rattus norvegicus	106-114
3009144-6	1986	The ACSA in these three peaks of murine tumor extract elutes in the same region as human tumor ACSA on reverse phase HPLC, has a dose-response curve parallel to that of PTH, and is fully inhibited by the PTH-(3-34) antagonist in both the renal cortical and rat osteosarcoma (ROS) adenylate cyclase assays.	ros	275-278	parathyroid hormone	Mus musculus	204-207
32442646-14	2021	IL33 overexpression in vitro resulted in reduced viability and ROS-capturing of HBECs, without influencing epithelial cell count, metabolic activity or barrier function.	ros	63-66	interleukin 33	Homo sapiens	0-4
3009144-9	1986	In the PTH-sensitive intact cell ROS assay, peak II exhibits no ACSA.	ros	33-36	parathyroid hormone	Mus musculus	7-10
6325192-1	1984	125I-calmodulin gel overlay techniques have been used to identify calmodulin-binding proteins in teleost retina, in a rod fragment preparation which contains rod inner and outer segments (RIS-ROS), and in RIS-ROS cytoskeletons.	ros	209-212	calmodulin 1	Rattus norvegicus	66-76
33340241-11	2021	Up-regulated NDUFA4L2 plays a critical role in the development of HPH, which mediates ROS production and proliferation of PASMCs, suggesting NDUFA4L2 as a potential new therapeutic target for PAH.	ros	86-89	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	13-21
33157090-0	2021	Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells.	ros	62-65	Kruppel-like factor 5	Mus musculus	18-22
33157090-12	2021	More importantly, we proved that curcumol could suppress KLF5-mediated LSEC angiogenesis by inhibiting ROS/ERK signaling.	ros	103-106	Kruppel-like factor 5	Mus musculus	57-61
33157090-13	2021	SIGNIFICANCE: We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis, and pointed out that curcumol targeted ROS/ERK-mediated KLF5 expression could inhibit LSEC angiogenesis.	ros	183-186	Kruppel-like factor 5	Mus musculus	53-57
33157090-13	2021	SIGNIFICANCE: We suggested that transcription factor KLF5 could be considered as a new target molecule of curcumol in improving liver fibrosis, and pointed out that curcumol targeted ROS/ERK-mediated KLF5 expression could inhibit LSEC angiogenesis.	ros	183-186	Kruppel-like factor 5	Mus musculus	200-204
6325192-5	1984	RIS-ROS cytoskeletons have 3 prominent calmodulin-binding proteins migrating at 240 and 18/19 K. These proteins produce faint bands in gel overlays of intact RIS-ROS, but prominent bands in overlays of whole retina.	ros	4-7	calmodulin 1	Rattus norvegicus	39-49
6327341-4	1984	Cyclic GMP levels increase five-fold in Balb/c retinas as ROS develop whereas, in affected retinas, the levels remain constant and low (about 5 pmol mg-1).	ros	58-61	5'-nucleotidase, cytosolic II	Mus musculus	7-10
33172542-7	2020	The results demonstrate that the anti-inflammatory mechanisms of SOCS1 and SOCS3 in macrophages are mediated via NRF-2-mediated thioredoxin upregulation resulting in the downregulation of ROS signal.Thus, our study supports the anti-oxidant role of SOCS1 and SOCS3 in the exquisite regulation of macrophage activation under oxidative stress.	ros	188-191	suppressor of cytokine signaling 3	Homo sapiens	75-80
33652112-12	2021	In agreement with the effect of KA over pro-inflammatory cytokines it inhibited oxidative stress (total ROS, superoxide production and superoxide positive cells) and NF-kappaB activation during peritonitis.	ros	104-107	zinc finger protein of the cerebellum 3	Mus musculus	32-34
33271756-6	2020	Synergistic effects of DBF were observed in combination with PARP-inhibitor olaparib most likely due to the induction of ROS production by the marine alkaloid.	ros	121-124	collagen type XI alpha 2 chain	Homo sapiens	61-65
33900847-0	2021	High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling.	ros	50-53	FAT atypical cadherin 1	Homo sapiens	29-32
33125139-2	2020	In the current study the role of the PDIA1 family member in breast carcinogenesis was investigated by measuring ROS generation, mitochondrial membrane disruption, ATP production and HLA-G protein levels on the surface of the cellular membrane in the presence or absence of PDIA1.	ros	112-115	prolyl 4-hydroxylase subunit beta	Homo sapiens	37-42
33711553-0	2021	919 syrup inhibits ROS-mediated leptin-induced anorexia by activating PPARgamma and improves gut flora abnormalities.	ros	19-22	peroxisome proliferator activated receptor gamma	Mus musculus	70-79
32936726-0	2020	CRISPR/Cas9 edited HSFA6a and HSFA6b of Arabidopsis thaliana offers ABA and osmotic stress insensitivity by modulation of ROS homeostasis.	ros	122-125	heat shock transcription factor A6B	Arabidopsis thaliana	30-36
32936726-7	2020	In addition to the above, the simultaneous editing of HSFA6a and HSFA6b lead to a reduced ROS accumulation, accompanied by increased expression of much abiotic stress and ABA-responsive genes, including involved in regulation of ROS level.	ros	90-93	heat shock transcription factor A6B	Arabidopsis thaliana	65-71
33932472-4	2021	Using Caco-2 as a cell model of the intestinal epithelial barrier (the first line of defense against mycotoxins), we showed that a strong production of ROS-dependent CXCL17 was triggered by mycotoxins via p38 and JNK pathways.	ros	152-155	C-X-C motif chemokine ligand 17	Homo sapiens	166-172
32936726-7	2020	In addition to the above, the simultaneous editing of HSFA6a and HSFA6b lead to a reduced ROS accumulation, accompanied by increased expression of much abiotic stress and ABA-responsive genes, including involved in regulation of ROS level.	ros	229-232	heat shock transcription factor A6B	Arabidopsis thaliana	65-71
32936726-8	2020	In conclusion, these results suggest that HSFA6a and HSFA6b may offer abiotic stress tolerance by regulating the ROS homeostasis in plants.	ros	113-116	heat shock transcription factor A6B	Arabidopsis thaliana	53-59
33722737-9	2021	Moreover, under the influence of TCS, the expression of iNOS was increased and at the same time the expression of nNOS was decreased, which was probably caused by high levels of ROS.	ros	178-181	nitric oxide synthase 1, neuronal	Mus musculus	114-118
34050453-6	2021	ROS activity assay showed that inhibiting ID2-AS1 attenuated the oxidative stress induced by 1-methy1-4-phenylpyridinium (MPP+).	ros	0-3	prostaglandin D2 receptor	Homo sapiens	46-49
34017078-7	2021	The loss of mitochondrial ING2 does not impair mtDNA repair, replication or transcription but leads to a decrease in mitochondrial ROS production, suggesting a detrimental impact on OXPHOS activity.	ros	131-134	inhibitor of growth family member 2	Homo sapiens	26-30
33219891-8	2021	The correlation of thiobarbituric acid reactive substance with VEGF/NF-kappaB and negative association of GSH with Casp3 show that squalene employs reduction in ROS regulation.	ros	161-164	caspase 3	Rattus norvegicus	115-120
33200130-3	2021	Here, we report that antiviral neuraminidase inhibitors constrain host neuraminidase activity, surface sialic acid release, ROS production, and NETs released by microbial-activated human neutrophils.	ros	124-127	neuraminidase 1	Homo sapiens	31-44
34012073-9	2021	This study not only illustrates a pyroptotic pathway linked with metabolites but also identifies an unreported principal axis extending from ROS-initiated DR6 endocytosis to caspase-8-mediated cleavage of GSDMC for potential clinical application in tumor therapy.	ros	141-144	tumor necrosis factor receptor superfamily, member 21	Mus musculus	155-158
34055630-5	2021	We show that, while carnosol does not affect HDACs, it promotes a ROS-dependent proteasome degradation of p300 and PCAF histone acetyl transferases (HATs) without affecting other HATs such as GCN5 and hMOF.	ros	66-69	E1A binding protein p300	Homo sapiens	106-110
33485149-0	2021	Loss of function of the chloroplast membrane K+/H+ antiporters AtKEA1 and AtKEA2 alters the ROS and NO metabolism but promotes drought stress resilience.	ros	92-95	K+ efflux antiporter 2	Arabidopsis thaliana	74-80
33485149-5	2021	The loss of function of AtKEA1 and AtKEA2 did not cause oxidative stress but it provoked an alteration of the ROS homeostasis affecting some ROS-generating enzymes.	ros	110-113	K+ efflux antiporter 2	Arabidopsis thaliana	35-41
33485149-5	2021	The loss of function of AtKEA1 and AtKEA2 did not cause oxidative stress but it provoked an alteration of the ROS homeostasis affecting some ROS-generating enzymes.	ros	141-144	K+ efflux antiporter 2	Arabidopsis thaliana	35-41
34055630-5	2021	We show that, while carnosol does not affect HDACs, it promotes a ROS-dependent proteasome degradation of p300 and PCAF histone acetyl transferases (HATs) without affecting other HATs such as GCN5 and hMOF.	ros	66-69	lysine acetyltransferase 2B	Homo sapiens	115-119
33485149-10	2021	Data suggest that the chloroplast osmotic balance and integrity maintained by AtKEA1 and AtKEA2 are necessary to keep the balance of ROS/RNS metabolism.	ros	133-136	K+ efflux antiporter 2	Arabidopsis thaliana	89-95
33632938-12	2021	Additionally, because NCOA4-siRNA disrupted ferritinophagy, DEX"s inhibitory impact on MTX-induced iron and ROS overproduction in HT22 cells was also annihilated.	ros	108-111	nuclear receptor coactivator 4	Mus musculus	22-27
34055630-5	2021	We show that, while carnosol does not affect HDACs, it promotes a ROS-dependent proteasome degradation of p300 and PCAF histone acetyl transferases (HATs) without affecting other HATs such as GCN5 and hMOF.	ros	66-69	lysine acetyltransferase 8	Homo sapiens	201-205
33626368-6	2021	This was associated with increased contributions of non-classical providers of electrons to the electron transport system (ETS) such as the proline dehydrogenase (ProDH) and the mitochondrial glycerol-3-phosphate dehydrogenase (mtG3PDH) alleviating complex I dysfunctions, as well as with increased ROS production per molecule of oxygen consumed.	ros	299-302	Glycerophosphate oxidase 1	Drosophila melanogaster	228-235
33960631-4	2021	Here, we found that the blue LED irradiation significantly suppressed the proliferation, migration and invasion of human OS cells, while we observed blue LED irradiation increased ROS production through increased NADPH oxidase enzymes NOX2 and NOX4, as well as decreased Catalase (CAT) expression levels.	ros	180-183	NADPH oxidase 4	Homo sapiens	244-248
33628364-10	2021	Conclusion: Our results demonstrated that the inhibition of Dot1l alleviated corneal oxidative stress and inflammation by inhibiting ROS production through the p38 MAPK pathway in HSK.	ros	133-136	mitogen-activated protein kinase 14	Mus musculus	160-168
33962063-0	2021	Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation.	ros	75-78	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	57-62
33548240-2	2021	Meanwhile, AMPD promotes the formation of substrates of xanthine oxidoreductase (XOR), which produces ROS as a byproduct.	ros	102-105	xanthine dehydrogenase	Rattus norvegicus	56-79
33548240-2	2021	Meanwhile, AMPD promotes the formation of substrates of xanthine oxidoreductase (XOR), which produces ROS as a byproduct.	ros	102-105	xanthine dehydrogenase	Rattus norvegicus	81-84
33548240-10	2021	Inhibition of XOR suppressed the production of tissue ROS and mitochondrial dysfunction and improved ventricular function under the condition of pressure overload in OLETF.	ros	54-57	xanthine dehydrogenase	Rattus norvegicus	14-17
33548240-11	2021	CONCLUSIONS: The results suggest that increases in the activity of XOR and the formation of XOR substrates by upregulated AMPD contribute to ROS-mediated diastolic ventricular dysfunction at the time of increased cardiac workload in diabetic hearts.	ros	141-144	xanthine dehydrogenase	Rattus norvegicus	67-70
33548240-11	2021	CONCLUSIONS: The results suggest that increases in the activity of XOR and the formation of XOR substrates by upregulated AMPD contribute to ROS-mediated diastolic ventricular dysfunction at the time of increased cardiac workload in diabetic hearts.	ros	141-144	xanthine dehydrogenase	Rattus norvegicus	92-95
33975099-5	2021	In the antagonism, Zn2+ would increase cellular Zn amount through increasing the expression of ZIP8 and ZIP14 transporters to manage the ROS generation, but the zinc-based NPs would decrease expression of these transporters to decrease cellular Cd amount to help maintain the cell viability.	ros	137-140	solute carrier family 39 member 8	Homo sapiens	95-99
33975099-5	2021	In the antagonism, Zn2+ would increase cellular Zn amount through increasing the expression of ZIP8 and ZIP14 transporters to manage the ROS generation, but the zinc-based NPs would decrease expression of these transporters to decrease cellular Cd amount to help maintain the cell viability.	ros	137-140	solute carrier family 39 member 14	Homo sapiens	104-109
33929387-9	2021	Overexpression of PDSS2 suppressed the release of ROS, iron content and ferroptosis of HCAECs, and promoted the proliferation of HCAECs.	ros	50-53	decaprenyl diphosphate synthase subunit 2	Homo sapiens	18-23
33933780-7	2021	In addition, we observed that exogenous hsa-miR-760 effectively elevated HMOX1 expression, reduced the reactive oxygen agents (ROS) levels, and rescued the lung cells from PM2.5-induced apoptosis.	ros	127-130	microRNA 760	Homo sapiens	40-51
33977107-8	2021	However, ROS inhibition effectively attenuated WIN-induced DNA damage and dysfunction of VEGF-AKT/FAK signal axis and eventually improved U251 cell proliferation, migration, and invasion.	ros	9-12	protein tyrosine kinase 2	Homo sapiens	98-101
33900313-8	2021	Moreover, our data revealed that activation of the ROS-derived and AKT/FAK/PAK1 pathways is involved in the erinacine S-mediated transcriptional activation of Fas-L and TRAIL through H3K4 trimethylation on their promoters.	ros	51-54	Fas ligand (TNF superfamily, member 6)	Mus musculus	159-164
33936239-11	2021	In conclusion, SXSM reduced the AngII-induced accumulation of ROS in the SAN through the PKC/NOX2 signaling pathway, improving the functioning of the SAN and preventing the decrease of heart rate in SSS mice.	ros	62-65	cytochrome b-245, beta polypeptide	Mus musculus	93-97
33383217-5	2021	Given that Slc7a11 could control ROS level through glutathione import, we measured intracellular ROS, then RANKL-induced ROS production was inhibited by alphaKG.	ros	33-36	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	11-18
33383217-5	2021	Given that Slc7a11 could control ROS level through glutathione import, we measured intracellular ROS, then RANKL-induced ROS production was inhibited by alphaKG.	ros	97-100	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	11-18
33383217-5	2021	Given that Slc7a11 could control ROS level through glutathione import, we measured intracellular ROS, then RANKL-induced ROS production was inhibited by alphaKG.	ros	97-100	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	11-18
33577944-5	2021	Additionally, we found that ROS derived from DUOX1 and 2 of NADPH oxidase were mainly responsible for PTEN inactivation, and the excess of ROS also simultaneously led to Trx-1 inactivation by dimerization.	ros	28-31	dual oxidase 1	Homo sapiens	45-56
33577944-8	2021	From the present study, we concluded that CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2, and the increased ROS led to the inactivation of PTEN, Trx-1 and Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	87-90	dual oxidase 1	Homo sapiens	103-114
33577944-13	2021	Additionally, we found that ROS derived from DUOX1 and 2 of NADPH oxidases were mainly responsible for oxidative inactivation PTEN, also simultaneously led to Trx-1 inactivation by dimerization.	ros	28-31	dual oxidase 1	Homo sapiens	45-56
33577944-16	2021	In conclusion, CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2 to oxidize PTEN and Trx-1 resulting in Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	60-63	dual oxidase 1	Homo sapiens	76-87
33561013-6	2021	Administration of an IRE1alpha inhibitor to lupus-prone MRL/lpr mice over eight weeks reduced mitochondrial ROS levels in peripheral blood neutrophils, while also restraining plasma-cell expansion and autoantibody formation.	ros	108-111	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	21-30
33561013-7	2021	In summary, these data are the first to identify a role for IRE1alpha in the hyperactivity of lupus neutrophils, with this pathway apparently upstream of mitochondrial dysfunction, mitochondrial ROS formation, and NETosis.	ros	195-198	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	60-69
33251225-0	2020	Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFkappaB/ROS Signaling Pathways.	ros	112-115	mitogen-activated protein kinase 3	Mus musculus	96-102
33251225-15	2020	Furthermore, the results showed that the inhibitory effect of adiponectin on PA-mediated inflammasome activation was regulated by AMPK-JNK/ErK1/2-NFkappaB/ROS signaling pathway.	ros	155-158	mitogen-activated protein kinase 3	Mus musculus	139-145
33486313-0	2021	CPT2 down-regulation promotes tumor growth and metastasis through inducing ROS/NFkappaB pathway in ovarian cancer.	ros	75-78	carnitine palmitoyltransferase 2	Homo sapiens	0-4
33486313-8	2021	Mechanistically, suppression of ROS/NFkappaB signaling pathway by increasing fatty acid oxidation-derived NADPH production was involved in the anti-tumorigenic functions of CPT2 in OC cells.	ros	32-35	carnitine palmitoyltransferase 2	Homo sapiens	173-177
33741719-6	2021	RNA sequencing revealed that mGPDH regulated the RAGE signaling pathway, and inhibition of RAGE or its ligand, S100A10, protected against the impaired mitochondrial bioenergetics and increased ROS generation caused by mGPDH knockdown in cultured podocytes.	ros	193-196	S100 calcium binding protein A10 (calpactin)	Mus musculus	111-118
33723743-0	2022	Dimethyl sulfoxide stimulates the AhR-Jdp2 axis to control ROS accumulation in mouse embryonic fibroblasts.	ros	59-62	Jun dimerization protein 2	Mus musculus	38-42
33002460-9	2020	In the upstream, ROS upregulation triggered by ART initiated AMPK-mTOR-ULK1 axis.	ros	17-20	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	61-65
33002460-9	2020	In the upstream, ROS upregulation triggered by ART initiated AMPK-mTOR-ULK1 axis.	ros	17-20	unc-51 like autophagy activating kinase 1	Homo sapiens	71-75
33723743-6	2022	Our findings provide evidence for the functional role of Jdp2 in controlling the AhR gene via Nrf2 and provide insights into how Jdp2 contributes to the regulation of ROS production and the cell spreading and apoptosis produced by the ligand DMSO in MEFs.	ros	167-170	Jun dimerization protein 2	Mus musculus	129-133
33790902-7	2021	Suppressing the expression of Ak4 in M1 macrophages with shRNA or siRNA enhances ATP production and decreases ROS production, bactericidal ability and glycolysis in M1 cells.	ros	110-113	adenylate kinase 4	Homo sapiens	30-33
32766860-0	2020	Overexpression of HvAKT1 improves barley drought tolerance by regulating root ion homeostasis and ROS and NO signaling.	ros	98-101	HvAKT1	Hordeum vulgare	18-24
33689540-4	2021	In Control cells, NAC/DTT reduced RyR2/SERCA2a activity blunting SCaTs, CaS frequency and CaW propagation, suggesting that basal ROS optimised Ca2+ signalling by maintaining RyR2/SERCA2a function and that these proteins facilitate CaW propagation.	ros	129-132	ryanodine receptor 2	Rattus norvegicus	34-38
32991157-10	2020	Moreover, SIRT5-mediated peptide self-assembly was found to depolarize mitochondria membrane potential and promote ROS formation.	ros	115-118	sirtuin 5	Homo sapiens	10-15
32693110-10	2020	Neutrophil adherent to fibrinogen, but not to polylysine, were able to produce ROS upon lipopolysaccharide challenge and ROS production was completely suppressed upon inhibition of Pyk2.	ros	121-124	PTK2 protein tyrosine kinase 2 beta	Mus musculus	181-185
33543924-0	2021	Targeting ROS-Dependent AKT/GSK-3beta/NF-kappaB and DJ-1/Nrf2 Pathways by Dapagliflozin Attenuates Neuronal Injury and Motor Dysfunction in Rotenone-Induced Parkinson"s Disease Rat Model.	ros	10-13	glycogen synthase kinase 3 alpha	Rattus norvegicus	28-37
33530947-9	2021	The hypersensitive response and ROS production were decreased in the ERF2-silenced plants.	ros	32-35	ethylene response factor 2	Solanum lycopersicum	69-73
33359576-9	2021	In this study, the regulation mechanism of the ROS-hnRNP A2/B1-COX-2 pathway on DU-induced reproductive damage in male rats was hypothesized, providing a new target for the prevention and treatment of chronic poisoning of DU.	ros	47-50	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	63-68
33530947-15	2021	Interestingly, ERF2 played a key role in multiple SA, JA and ROS signaling pathways to confer resistance to invasion by S. lycopersici.	ros	61-64	ethylene response factor 2	Solanum lycopersicum	15-19
33359686-10	2021	We conclude that AntiOxBEN2 and AntiOxCIN4 increase ROS levels, which stimulates NRF2 expression and, as a consequence, SOD2 and GSH levels.	ros	52-55	superoxide dismutase 2	Homo sapiens	120-124
33474594-7	2021	TLR4 gene knockout mouse and cytoplasmic and mitochondrial ROS scavenger were used for the regulation of ICAM-1 expression.	ros	59-62	intercellular adhesion molecule 1	Mus musculus	105-111
32627147-0	2020	Particulate matter exposure promotes Pseudomonas aeruginosa invasion into airway epithelia by upregulating PAFR via the ROS-mediated PI3K pathway.	ros	120-123	platelet activating factor receptor	Homo sapiens	107-111
32627147-6	2020	PM exposure promoted P. aeruginosa invasion into BEAS-2B cells through ROS-mediated PI3K pathway which enhanced the expression of PAFR, which could be alleviated by treatment with NAC, LY294002, and BAY 11-7082.	ros	71-74	platelet activating factor receptor	Homo sapiens	130-134
32707370-14	2020	It is of advantage to prevent apoptosis through SIRT3-mediated SOD2 deacetylation that reduces ROS accumulation and restores mitochondrial function.	ros	95-98	superoxide dismutase 2	Homo sapiens	63-67
33474594-12	2021	Furthermore, we found that knocking out of TLR4 led to inhibited cytoplasmic and mitochondrial ROS production, which in turn, attenuated ICAM-1 expression at both the protein and cell surface levels.	ros	95-98	intercellular adhesion molecule 1	Mus musculus	137-143
33470533-7	2021	The RT-qPCR and Western blot analyses revealed that NRG-1 mitigated the IR-induced up-regulation of NOX4 and ROS production.	ros	109-112	neuregulin 1	Homo sapiens	52-57
33474594-13	2021	CONCLUSION: This study demonstrates that the mechanism of ICAM-1-mediated macrophage phagocytosis is depending on TLR4-mediated ROS production and provides significant light on macrophage ICAM-1 in endotoxemia.	ros	128-131	intercellular adhesion molecule 1	Mus musculus	58-64
33345387-12	2021	Finally, nude mice xenograft model experimental results demonstrate DIAPH3 knock down could decrease tumour growth and TrxR1 expression and ROS levels in vivo.	ros	140-143	diaphanous related formin 3	Mus musculus	68-74
33486268-13	2021	CONCLUSION: Our results suggest that Daph triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway.	ros	51-54	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	133-137
33008134-3	2020	Research has revealed that A1M can ameliorate heme and ROS-induced injuries in cell cultures, organs, explants and animal models.	ros	55-58	alpha-1-microglobulin/bikunin precursor	Homo sapiens	27-30
32911634-5	2020	However, XOR activity contributes to a regular level of ROS and RNS, which appears essential for the proper functioning of many physiological pathways.	ros	56-59	xanthine dehydrogenase	Homo sapiens	9-12
33004257-4	2021	In this review, we focus on the emerging role of GSNOR as a master regulator in oxidative stress through its regulation of the interaction of ROS, RNS, and Fe, and highlight recent discoveries in post-translational modifications of GSNOR and functional variations of natural GSNOR variants during oxidative stress.	ros	142-145	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	49-54
33470533-10	2021	In conclusion, NRG-1 can reduce ROS production by inhibiting NOX4 through ERK1/2 and inhibit the NLRP3/caspase-1 pathway to attenuate myocardial oxidative damage and inflammation in MIRI.	ros	32-35	neuregulin 1	Homo sapiens	15-20
33509753-11	2021	The total intracellular ROS and mitochondrial ROS levels in NDUFA13fl/- mice were also significantly increased.	ros	24-27	NADH:ubiquinone oxidoreductase subunit A13	Mus musculus	60-67
33509753-11	2021	The total intracellular ROS and mitochondrial ROS levels in NDUFA13fl/- mice were also significantly increased.	ros	46-49	NADH:ubiquinone oxidoreductase subunit A13	Mus musculus	60-67
33509753-13	2021	CONCLUSIONS: Hepatocytes-specific NDUFA13 ablation can trigger spontaneous hepatitis in mice possibly mediated by the activation of ROS/NF-kappaB/NLRP3 signaling.	ros	132-135	NADH:ubiquinone oxidoreductase subunit A13	Mus musculus	34-41
32964473-14	2021	Pretreatment of HIBEpiCs with ML221, DPI (Nox4 inhibitor), NAC (ROS inhibitor) or PD98059 (ERK inhibitor) reduced apelin-induced cholangiocyte proliferation.	ros	64-67	apelin	Mus musculus	114-120
33470533-10	2021	In conclusion, NRG-1 can reduce ROS production by inhibiting NOX4 through ERK1/2 and inhibit the NLRP3/caspase-1 pathway to attenuate myocardial oxidative damage and inflammation in MIRI.	ros	32-35	NADPH oxidase 4	Homo sapiens	61-65
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	ros	171-174	apelin receptor	Homo sapiens	24-27
33503428-6	2021	Knockout of PTPMT1 stops the maturation of CL and impairs the assembly of ETC complexes, leading to further electron leakage and ROS accumulation at ETC in hypoxia.	ros	129-132	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1	Felis catus	12-18
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	ros	171-174	glycogen synthase kinase 3 alpha	Homo sapiens	51-59
33310292-5	2021	Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-l-cysteine (NAC) clearing ROS delayed GSCs apoptosis.	ros	113-116	NADPH oxidase 1	Homo sapiens	94-98
32473481-5	2020	The resulted ROS could induce DNA damage of the tumor cells, thus enhancing the sensitivity to the inhibitor of NAMPT (FK866) to downregulate NAD/ERK/NF-kappaB signal pathways, and eventually simultaneously prevent cancer progression.	ros	13-16	nicotinamide phosphoribosyltransferase	Homo sapiens	112-117
33519423-0	2020	Atorvastatin Attenuates Isoflurane-Induced Activation of ROS-p38MAPK/ATF2 Pathway, Neuronal Degeneration, and Cognitive Impairment of the Aged Mice.	ros	57-60	mitogen-activated protein kinase 14	Mus musculus	61-68
32470336-1	2020	Uncoupling protein-2 (UCP2) is a mitochondrial inner membrane anion carrier and is emerging as a negative regulator of ROS production.	ros	119-122	uncoupling protein 2	Homo sapiens	0-20
33480316-9	2021	Harmine exhibited G2M arrest with ROS induced effective role in PARP mediated apoptosis as well as anti-inflammatory action on HeLa cells.	ros	34-37	collagen type XI alpha 2 chain	Homo sapiens	64-68
33519423-8	2020	Western blotting revealed a decrease in cleaved caspase-9 and caspase-3 expression in line with ROS levels.	ros	96-99	caspase 9	Mus musculus	48-57
32470336-1	2020	Uncoupling protein-2 (UCP2) is a mitochondrial inner membrane anion carrier and is emerging as a negative regulator of ROS production.	ros	119-122	uncoupling protein 2	Homo sapiens	22-26
33414469-7	2021	Mechanistically, the inhibition of MSH2 by Nrf2 was in a ROS-independent manner.	ros	57-60	mutS homolog 2	Homo sapiens	35-39
32645629-8	2020	We further demonstrated an antioxidant effect of DMF via reduced production of ROS, which was mediated through NOX4 inhibition.	ros	79-82	NADPH oxidase 4	Homo sapiens	111-115
33708107-7	2020	Furthermore, autophagy pathway p62/LC3B, ROS production and NF-kappaB were all activated by RANKL stimulation and blocked by DG pretreatment.	ros	41-44	TNF superfamily member 11	Rattus norvegicus	92-97
33397952-4	2021	Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS, activation of ERK, JNK and caspase-3, impaired mitochondrial function and reduced fatty acid oxidation.	ros	69-72	NADPH oxidase 4	Mus musculus	56-60
32512010-8	2020	Collectively, our results demonstrates that HG-induced over production of ROS, disrupts the antioxidant defence mechanism and mitochondrial dysfunction, leading to alterations of inflammatory mediators and neurodegenerative markers through the ERK1/2-Akt-tuberin-mTOR dependent signalling pathway in RGC-5 cells.	ros	74-77	mitogen-activated protein kinase 3	Mus musculus	244-250
32895999-6	2021	It is imperative to investigate whether: (1) LAL improves sperm function by reducing reactive oxidative species (ROS); (2) LAL has differential effects on sperm function between men with normal and elevated ROS.	ros	207-210	lipase A, lysosomal acid type	Homo sapiens	123-126
32554303-3	2020	Our data indicate that exposure of pulmonary arterial endothelial cells (PAEC) to TGF-beta1 disrupted mitochondrial function as determined by enhanced mitochondrial ROS generation, decreased mitochondrial membrane potential, and disrupted mitochondrial bioenergetics.	ros	165-168	transforming growth factor beta-1 proprotein	Ovis aries	82-91
33245190-2	2021	In this study, we provide evidence that GSNOR is induced at the translational level in response to hydrogen peroxide and mitochondrial ROS.	ros	135-138	alcohol dehydrogenase 5 (class III), chi polypeptide	Homo sapiens	40-45
33413468-10	2021	In addition, both PSEN1 and PSEN2-BMECs displayed reduced bioenergetics, lysosomal acidification, autophagy, while showing an increase in radical oxygen species (ROS) production.	ros	162-165	presenilin 1	Homo sapiens	18-23
32895999-11	2021	CONCLUSIONS: We report for the first time that LAL only improves sperm quality in infertile men who have baseline high-ROS levels prior to treatment.	ros	119-122	lipase A, lysosomal acid type	Homo sapiens	47-50
33985416-5	2021	B. dentium cell-free supernatant and gamma-glutamylcysteine were taken up by human colonic T84 cells, increased glutathione levels, and reduced ROS generated by the ER-stressors thapsigargin and tunicamycin.	ros	144-147	epiregulin	Homo sapiens	165-167
32860664-10	2021	Thus, we concluded that obstructive cholestasis decreases expression of PGC-1alpha, which may lead to decreased expression of mitochondrial antioxidant enzymes, thereby rendering mice with cholestatic livers vulnerable to ROS-induced cell death.	ros	222-225	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	72-82
32157557-8	2020	RPIA methylation supports ROS clearance by enhancing NADPH production and fuels nucleic acid synthesis by increasing ribose supply.	ros	26-29	ribose 5-phosphate isomerase A	Homo sapiens	0-4
32913508-0	2020	Ulinastatin attenuates monocyte-endothelial adhesion via inhibiting ROS transfer between the neighboring vascular endothelial cells mediated by Cx43.	ros	68-71	gap junction protein alpha 1	Homo sapiens	144-148
32913508-6	2020	The results showed that ulinastatin could attenuate ROS transmission between the neighboring HUVECs via inhibiting Cx43 function.	ros	52-55	gap junction protein alpha 1	Homo sapiens	115-119
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	ros	47-50	superoxide dismutase 2	Homo sapiens	70-100
32913508-7	2020	With the decrease of ROS, JAK2/STAT3 signaling pathway and its downstream MMP2 and MMP9 expression were downregulated.	ros	21-24	Janus kinase 2	Homo sapiens	26-30
32913508-7	2020	With the decrease of ROS, JAK2/STAT3 signaling pathway and its downstream MMP2 and MMP9 expression were downregulated.	ros	21-24	matrix metallopeptidase 2	Homo sapiens	74-78
32913508-9	2020	Thus, we can conclude that ulinastatin attenuates adhesion molecules expression and monocyte-endothelial adhesion, mechanism of which is related that ulinastatin inhibits ROS transfer between the neighboring vascular endothelial cells mediated by Cx43, resulting in the inactivation of JAK2/STAT3 signaling pathway, and its downstream MMP2 and MMP9 expression decrease.	ros	171-174	gap junction protein alpha 1	Homo sapiens	247-251
32913508-9	2020	Thus, we can conclude that ulinastatin attenuates adhesion molecules expression and monocyte-endothelial adhesion, mechanism of which is related that ulinastatin inhibits ROS transfer between the neighboring vascular endothelial cells mediated by Cx43, resulting in the inactivation of JAK2/STAT3 signaling pathway, and its downstream MMP2 and MMP9 expression decrease.	ros	171-174	Janus kinase 2	Homo sapiens	286-290
33597103-0	2021	Corrigendum to "Proopiomelanocortin gene delivery induces apoptosis in melanoma through NADPH oxidase 4-mediated ROS generation" [Free Radic.	ros	113-116	NADPH oxidase 4	Homo sapiens	88-103
33394232-13	2021	Acacetin and apigenin-induced ROS is responsible for the induction of cell cycle arrest and activation of caspase-cascade pathways in U87 cells.	ros	30-33	caspase 8	Homo sapiens	106-113
33009206-2	2021	Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water.	ros	47-50	superoxide dismutase 2	Homo sapiens	102-106
33693448-14	2021	ROS scavengers GPx-3 and GPx-7 were ~50% lower in LLC hearts.	ros	0-3	glutathione peroxidase 7	Homo sapiens	25-30
33197464-8	2020	Our data proved that: (i) the rise of mitochondrial ROS determines a very rapid translocation of APE1 from the intermembrane space (IMS) into the matrix; and (ii) TIM23/PAM machinery complex is responsible for the matrix translocation of APE1.	ros	52-55	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	97-101
33488293-7	2020	Altogether, these findings suggest that MCPIP-1 plays a negative role in regulating neutrophil activities through suppressing the production of ROS, MPO, and proinflammatory cytokines and inhibiting the migration.	ros	144-147	zinc finger CCCH type containing 12A	Mus musculus	40-47
33319071-4	2020	Depletion of TMEM65 led to a mild increase in ROS generation and upregulation of the mRNA levels of oxidative stress suppressors, such as NFE2L2 and SESN3, indicating that TMEM65 knockdown induced an oxidative stress response.	ros	46-49	transmembrane protein 65	Homo sapiens	13-19
32913508-9	2020	Thus, we can conclude that ulinastatin attenuates adhesion molecules expression and monocyte-endothelial adhesion, mechanism of which is related that ulinastatin inhibits ROS transfer between the neighboring vascular endothelial cells mediated by Cx43, resulting in the inactivation of JAK2/STAT3 signaling pathway, and its downstream MMP2 and MMP9 expression decrease.	ros	171-174	matrix metallopeptidase 2	Homo sapiens	335-339
33197464-8	2020	Our data proved that: (i) the rise of mitochondrial ROS determines a very rapid translocation of APE1 from the intermembrane space (IMS) into the matrix; and (ii) TIM23/PAM machinery complex is responsible for the matrix translocation of APE1.	ros	52-55	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	238-242
32979364-0	2020	Indoxyl sulfate promotes osteogenic differentiation of vascular smooth muscle cells by miR-155-5p-dependent downregulation of matrix Gla protein via ROS/NF-kappaB signaling.	ros	149-152	matrix Gla protein	Homo sapiens	126-144
29796942-5	2020	At the molecular levels, Yap overexpression sustained mitochondrial potential, normalized the mitochondrial respiratory function, reduced ROS overproduction, limited HtrA2/Omi release from mitochondria into the nucleus, and suppressed pro-apoptotic proteins activation.	ros	138-141	yes-associated protein 1	Mus musculus	25-28
33618464-4	2020	We reported that not only PM2.5-0.3, but also, to a lesser extent, its inorganic chemical fraction, NEM2.5-0.3, and organic chemical fraction, OEM2.5-0.3, were able to significantly induce ROS overproduction and oxidative damage notwithstanding the early activation of NRF2 signaling pathway.	ros	189-192	nebulin	Homo sapiens	100-104
32985256-9	2020	In terms of mechanism, the renoprotective effect of the GLP-1 would be exerted via the GLP1R-AMPK-mTOR-autophagy-ROS signaling axis.	ros	113-116	glucagon like peptide 1 receptor	Homo sapiens	56-61
32270590-2	2020	In this study, we found that IGF-1 activated NF-kappaB and NLRP3 inflammatory signaling via IRS-1/mPGES-1/NOX2-regulated ROS.	ros	121-124	insulin-like growth factor 1	Mus musculus	29-34
32892025-11	2020	Collectively, DEHP activates the NOX-ROS-PP2B pathway, which in turns inhibits TRPV1/Ca2+-dependent signaling and abrogates the statin-conferred pleiotropic protection in ECs.	ros	37-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	79-84
32270590-2	2020	In this study, we found that IGF-1 activated NF-kappaB and NLRP3 inflammatory signaling via IRS-1/mPGES-1/NOX2-regulated ROS.	ros	121-124	cytochrome b-245, beta polypeptide	Mus musculus	106-110
33230096-2	2020	Here, we demonstrate in primary leukemic cells and in cell lines that mutated ETNK1 causes a significant increase in mitochondrial activity, ROS production, and Histone H2AX phosphorylation, ultimately driving the increased accumulation of new mutations.	ros	141-144	ethanolamine kinase 1	Homo sapiens	78-83
32114856-5	2020	Consistent with this finding, knocking down the alpha1 or beta1 subunit of Na+/K+-ATPase promotes the generation of intracellular ROS by cisplatin and potentiates cisplatin-induced apoptosis and autophagy in A549 cells.	ros	130-133	ATPase Na+/K+ transporting subunit beta 1	Homo sapiens	48-88
33144519-5	2020	We also observed that p101VVKR777AAAA neutrophils showed enhanced p84-dependent ROS responses to fMLP and C5a, suggesting that competition may exist between p101/p110gamma and p84/p110gamma for Gbetagamma subunits downstream of GPCR activation.	ros	80-83	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	162-171
33330441-0	2020	NDUFA4L2 Regulated by HIF-1alpha Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.	ros	132-135	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	0-8
33330441-10	2020	During experiments, we incidentally discovered that autophagy and the ROS inhibitor could be used to facilitate the rescuing of tumor cells whose NDUFA4L2 was knocked down.	ros	70-73	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	146-154
33211772-8	2020	Consequently, fragmented mitochondria lost their membrane integrity and ROS was accumulated to trigger caspase 9-dependent apoptosis before autophagic rescue.	ros	72-75	caspase 9	Mus musculus	103-112
32960947-10	2020	Remarkably, treatment with BPA in an antioxidant-rich media, neurobasal A (NBA), or with ROS scavenger tauroursodeoxycholic acid (TUDCA) mitigated the BPA-induced increase and decrease in Npy.	ros	89-92	neuropeptide Y	Mus musculus	188-191
32835867-3	2020	Curcumin treatment enhances CTSC level in CRCs; however, CTSC silencing with subsequent curcumin treatment (sequential treatment) induces ER stress and autophagic dysregulation accompanied by lysosomal permeabilization and ROS generation.	ros	223-226	cathepsin C	Mus musculus	57-61
33177495-8	2020	Further, this study demonstrates that quercetin reduces ROS via SIRT3-mediated acetylation of SOD2"s K68 residue.	ros	56-59	superoxide dismutase 2	Homo sapiens	94-98
33159039-0	2020	Parp3 promotes astrocytic differentiation through a tight regulation of Nox4-induced ROS and mTorc2 activation.	ros	85-88	NADPH oxidase 4	Mus musculus	72-76
33159039-5	2020	The accumulation of ROS contributes to the decreased activity of mTorc2 as a result of an oxidation-induced and Fbxw7-mediated ubiquitination and degradation of Rictor.	ros	20-23	CREB regulated transcription coactivator 2	Mus musculus	65-71
33019842-5	2021	We found that nuclear-aggregated PRCC-TFE3 fusions constitutively activated expression of the target gene E3 ubiquitin ligase PRKN, leading to rapid PINK1-PRKN-dependent mitophagy that promoted cell survival under mitochondrial oxidative damage as well as cell proliferation through decreasing mitochondrial ROS formation.	ros	308-311	transcription factor binding to IGHM enhancer 3	Homo sapiens	38-42
33159039-5	2020	The accumulation of ROS contributes to the decreased activity of mTorc2 as a result of an oxidation-induced and Fbxw7-mediated ubiquitination and degradation of Rictor.	ros	20-23	RPTOR independent companion of MTOR, complex 2	Mus musculus	161-167
33144519-5	2020	We also observed that p101VVKR777AAAA neutrophils showed enhanced p84-dependent ROS responses to fMLP and C5a, suggesting that competition may exist between p101/p110gamma and p84/p110gamma for Gbetagamma subunits downstream of GPCR activation.	ros	80-83	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	180-189
33035385-4	2020	RNase A bioreversibly modified with phenylboronic acid groups via a ROS-cleavable carbamate linker is incorporated into the triblock copolymer nanoparticles with high efficiency through a pH-reversible phenylboronic acid-catechol linkage.	ros	68-71	ribonuclease A family member 1, pancreatic	Homo sapiens	0-7
33046439-13	2021	Additionally, an increase in the ROS level was prohibited in HG-treated podocytes with the knockdown of Nox4, Smad3, or ezrin.	ros	33-36	NADPH oxidase 4	Homo sapiens	104-108
33046439-13	2021	Additionally, an increase in the ROS level was prohibited in HG-treated podocytes with the knockdown of Nox4, Smad3, or ezrin.	ros	33-36	SMAD family member 3	Homo sapiens	110-115
33046439-14	2021	Taken together, our findings provided evidence that Smad3-mediated ezrin activation upregulates Nox4 expression and ROS production, by suppressing PKA activity, which may at least in part contribute to HG-induced podocyte apoptosis.	ros	116-119	SMAD family member 3	Homo sapiens	52-57
33035385-6	2020	Upon cellular internalization, the cooperative release of DOX and RNase A from the triblock copolymer nanoparticles is triggered at multiple stages by endosomal acidic environment and subsequent DOX-enhanced intracellular ROS environment.	ros	222-225	ribonuclease A family member 1, pancreatic	Homo sapiens	66-73
32929153-0	2020	Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.	ros	63-66	tripartite motif containing 2	Homo sapiens	22-27
33231124-0	2020	SENP3 regulates high glucose-induced endothelial dysfunction via ROS dependent signaling.	ros	65-68	SUMO/sentrin specific peptidase 3	Mus musculus	0-5
32929153-0	2020	Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.	ros	63-66	protein tyrosine kinase 2	Homo sapiens	86-89
32929153-6	2020	Regarding the mechanism involved, TRIM2 activated ROS-related E2-related factor 2 (NRF2)/antioxidant response element (ARE) signaling and the integrin/focal adhesion kinase (FAK) pathway.	ros	50-53	tripartite motif containing 2	Homo sapiens	34-39
32929153-11	2020	TRIM2 accelerates pancreatic cancer progression via the ROS-related NRF2/ITGB7/FAK axis.	ros	56-59	tripartite motif containing 2	Homo sapiens	0-5
32929153-11	2020	TRIM2 accelerates pancreatic cancer progression via the ROS-related NRF2/ITGB7/FAK axis.	ros	56-59	protein tyrosine kinase 2	Homo sapiens	79-82
33231124-5	2020	In addition, the effects of SENP3 on ROS-related signaling pathways were investigated in high-glucose cultured HAECs.	ros	37-40	SUMO/sentrin specific peptidase 3	Mus musculus	28-33
33003464-8	2020	rho- petites expressing alpha-synuclein from fully-induced MET25/GAL1 promoters exhibit increased ROS levels, loss of mitochondrial membrane potential, and nuclear DNA fragmentation, with increasing copies of alpha-synuclein.	ros	98-101	galactokinase	Saccharomyces cerevisiae S288C	65-69
32947170-0	2020	Prolactin peptide (pPRL) induces anti-prolactin antibodies, ROS and cortisol but suppresses specific immune responses in rainbow trout.	ros	60-63	prolactin	Oncorhynchus mykiss	0-9
33042402-0	2020	Exosomes released by human umbilical cord mesenchymal stem cells protect against renal interstitial fibrosis through ROS-mediated P38MAPK/ERK signaling pathway.	ros	117-120	mitogen activated protein kinase 14	Rattus norvegicus	130-137
33042402-15	2020	In conclusion, the results showed that hucMSC-Ex had positive effects towards UUO-induced renal fibrosis and apoptosis of renal tubular epithelial cells, and its mechanism of action was associated with inhibition of ROS-mediated p38MAPK/ERK signaling pathway.	ros	216-219	mitogen activated protein kinase 14	Rattus norvegicus	229-236
32522548-8	2020	Furthermore, unlike heme, the addition of FeTPPS completely reversed the cytotoxicity and ROS level induced by hIAPP, which was consistent with its strong inhibitory activity.	ros	90-93	islet amyloid polypeptide	Homo sapiens	111-116
32873786-4	2020	However, antioxidant therapy induced elevated ROS levels to activate the Unc-51-like kinase 1 (ULK1) pathway to promote protective autophagy and ULK1-dependent mitophagy.	ros	46-49	unc-51 like autophagy activating kinase 1	Homo sapiens	73-93
32873786-4	2020	However, antioxidant therapy induced elevated ROS levels to activate the Unc-51-like kinase 1 (ULK1) pathway to promote protective autophagy and ULK1-dependent mitophagy.	ros	46-49	unc-51 like autophagy activating kinase 1	Homo sapiens	95-99
32873786-4	2020	However, antioxidant therapy induced elevated ROS levels to activate the Unc-51-like kinase 1 (ULK1) pathway to promote protective autophagy and ULK1-dependent mitophagy.	ros	46-49	unc-51 like autophagy activating kinase 1	Homo sapiens	145-149
32592929-7	2020	The above mentioned results indicate that Lm-PHB2 could assist OPA1 and HAX1 to maintain mitochondrial morphology and decrease ROS levels by the translocation from the nucleus to mitochondria under oxidative stress.	ros	127-130	HCLS1 associated protein X-1	Homo sapiens	72-76
32882215-8	2020	Current results revealed ROS-mediated activation of MAPKs, namely, p-p38, p-ERK1/2 in the heart tissue of ISO administered group.	ros	25-28	mitogen activated protein kinase 14	Rattus norvegicus	69-72
33042327-0	2020	The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis.	ros	106-109	sepiapterin reductase	Homo sapiens	21-42
32882215-8	2020	Current results revealed ROS-mediated activation of MAPKs, namely, p-p38, p-ERK1/2 in the heart tissue of ISO administered group.	ros	25-28	mitogen activated protein kinase 3	Rattus norvegicus	76-82
32938726-6	2020	Interestingly, ROS-dependent Ca release was much more prevalent in the pathogenetically pivotal CD28null subset compared with the CD28+ T cells, whereas the established mediators of the classical pathways for beta2 integrin activation (PKC, PI3K, and PLC) were similarly activated in both T cell subsets.	ros	15-18	CD28 molecule	Homo sapiens	96-100
32683294-10	2020	These results indicate that As2O3 inhibits occludin expression in vivo and in vitro at least partially via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	ros	111-114	occludin	Homo sapiens	43-51
32683294-10	2020	These results indicate that As2O3 inhibits occludin expression in vivo and in vitro at least partially via the ROS/ERK/ELK1/MLCK and ROS/p38 MAPK signaling pathways.	ros	133-136	occludin	Homo sapiens	43-51
32800851-9	2020	After enhancing miR-23a-5p expression or silencing PPARalpha gene, H/R-caused cell damage was further aggravated compared with NC group, and ROS level was increased associated with the decreased levels of FOXO3alpha, PGC-1alpha, Nrf2, CAT, NQO1, HO-1 and SOD2.	ros	141-144	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	217-227
33004801-5	2020	Mechanistically, BAFF activated NLRP3 inflammasomes by promoting the association of cIAP-TRAF2 with components of NLRP3 inflammasomes, and by inducing Src activity-dependent ROS production and potassium ion efflux.	ros	174-177	TNF superfamily member 13b	Homo sapiens	17-21
32800233-2	2020	In the present study, we assessed F induced oxidative stress through monitoring biochemical parameters and looked into the effect of chronic F exposure on two crucial DNA repair genes Ogg1 and Rad51 having important role against ROS induced DNA damages.	ros	229-232	RAD51 recombinase	Mus musculus	193-198
32470468-10	2020	Strikingly, chloroquine (CQ), 3-methyladenine (3-MA) and knockdown of autophagy-related gene (Atg5) abrogated the inhibitory effects of Met on H9c2-H2O2-CM and mtDNA-ATP-induced NLRP3 expression, release of IL-1beta and IL-18 as well as ROS production in RAW264.7 macrophages.	ros	237-240	autophagy related 5	Mus musculus	94-98
33001475-3	2020	Here, we show that stress-induced upregulation of the ROS-generating protein Nox4 at the ER-mitochondria contact sites (MAMs) is a pro-survival mechanism that inhibits calcium transfer through InsP3 receptors (InsP3 R).	ros	54-57	NADPH oxidase 4	Homo sapiens	77-81
32155298-6	2020	AMP significantly suppressed the intracellular ROS production and expression levels of ROS producing enzymes NADPH oxidase 2 (NOX2) and NOX4.	ros	87-90	NADPH oxidase 4	Homo sapiens	136-140
33001475-6	2020	These results uncover a hitherto unrecognized stress pathway, whereby a ROS-generating protein mediates pro-survival effects through spatially confined signaling at the MAM to regulate ER to mitochondria calcium flux and triggering of the mPT.	ros	72-75	sarcoglycan gamma	Homo sapiens	169-172
32679366-16	2020	Mechanistically, xCT promotes cellular homeostasis by regulating intracellular ROS and GSH levels, which are critical to photoreceptor survival after retinal detachment.	ros	79-82	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	17-20
32723812-2	2020	Here, we showed that the mitochondrial FUN14 domain-containing protein-1 (FUNDC1), an effector of Parkin-independent mitophagy, also participates in cellular plasticity by sustaining oxidative bioenergetics, buffering ROS production, and supporting cell proliferation.	ros	218-221	FUN14 domain containing 1	Homo sapiens	39-72
32723812-2	2020	Here, we showed that the mitochondrial FUN14 domain-containing protein-1 (FUNDC1), an effector of Parkin-independent mitophagy, also participates in cellular plasticity by sustaining oxidative bioenergetics, buffering ROS production, and supporting cell proliferation.	ros	218-221	FUN14 domain containing 1	Homo sapiens	74-80
32723812-5	2020	Independently of its previously identified role in mitophagy, FUNDC1 enabled LonP1 proteostasis, which in turn preserved complex V function and decreased ROS generation.	ros	154-157	FUN14 domain containing 1	Homo sapiens	62-68
32567066-8	2020	Caspase 8 was activated in cells treated by CPF but accompaniment of PILO with CPF led to activation of caspase 9, 8 and 3 and ROS overproduction.	ros	127-130	caspase 8	Homo sapiens	0-9
32803108-10	2020	These data suggest that Nox4-mediated ROS in bone osteoblastic cells may be dispensable for sex steroid deficiency-induced bone loss and senescence.	ros	38-41	NADPH oxidase 4	Mus musculus	24-28
32451640-4	2020	Furthermore, PBM could activate mitochondrial ROS, which could elevate the phosphorylation levels of JNK and IKB in HGMSCs, and further activate NF-kappaB as the nuclear translocation of p65 is elevated.	ros	46-49	RELA proto-oncogene, NF-kB subunit	Homo sapiens	187-190
32650805-14	2020	CONCLUSIONS: miR-708 plays a protective role in H2O2-induced MC3T3-E1 osteoblasts apoptosis and its protective effect is proceeded by regulating ROS level and PTEN expression level.	ros	145-148	microRNA 708	Mus musculus	13-20
32994511-9	2020	Our study mechanistically demonstrates that ADMA is involved in the progression of kidney cell injury under high glucose condition by targeting coordinated complex mechanisms involving the NOX4- ROS-ERK pathway.	ros	195-198	NADPH oxidase 4	Homo sapiens	189-193
32442565-6	2020	Treatment of fine dust from Beijing, China (CFD) increased intracellular ROS levels in HaCaT cells triggering DNA damage and apoptosis.	ros	73-76	complement factor D	Homo sapiens	44-47
32442565-7	2020	Treatment of SNF7 dose-dependently attenuated CFD-induced surge of intracellular ROS levels in keratinocytes by increasing antioxidant defense enzymes.	ros	81-84	complement factor D	Homo sapiens	46-49
32240120-6	2020	Mechanistically, exophilin-5 regulates extracellular superoxide release, intracellular ROS production, and phosphoinositide 3-kinase activity by controlling intracellular trafficking of Nox2-containing vesicles, which seems to prevent the overactivation of pathogenic Th2 cells mediated by IL-33.	ros	87-90	exophilin 5	Mus musculus	17-28
32927859-7	2020	The hyperproliferative BM-MSC phenotype was lost in aged (1.5 yr) mice, and Tsc1 inactivation was also accompanied by elevated ROS and increased senescence.	ros	127-130	TSC complex subunit 1	Mus musculus	76-80
32606805-0	2020	AMPK alpha1 Downregulates ROS Levels Through Regulating Trx Leading to Dysfunction of Apoptosis in Non-Small Cell Lung Cancer.	ros	26-29	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-11
32606805-12	2020	In A549 cells, overexpression of AMPK alpha1 promoted proliferation, suppressed ROS levels and inhibited apoptosis.	ros	80-83	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	33-44
32903215-7	2020	Overexpression of PARK2, but not mutant PARK2 lacking enzyme activity, in H4 cells decreased ROS and Tomm20 accumulation and reversed mitophagy dysfunction after sevoflurane treatment.	ros	93-96	parkin RBR E3 ubiquitin protein ligase	Rattus norvegicus	18-23
33042327-9	2020	ROS scavenger NAC was used to inhibit increased ROS caused by the SPR knockdown.	ros	0-3	sepiapterin reductase	Homo sapiens	66-69
33042327-9	2020	ROS scavenger NAC was used to inhibit increased ROS caused by the SPR knockdown.	ros	48-51	sepiapterin reductase	Homo sapiens	66-69
32687433-8	2020	Moreover, inhibition of survivin induced oxidative stress and DNA damage, showing with the increase of ROS level, the positive gammaH2A signal, and the increase of Rad51 level.	ros	103-106	baculoviral IAP repeat-containing 5	Mus musculus	24-32
33042327-11	2020	The knockdown of SPR causes decreased intracellular BH4 and increased intracellular ROS and inhibits the proliferation of MDA-MB-231 and MDA-MB-468 cells.	ros	84-87	sepiapterin reductase	Homo sapiens	17-20
33042327-15	2020	The knockdown of SPR suppresses the proliferation of breast cancer cells by inducing ROS-mediated apoptosis.	ros	85-88	sepiapterin reductase	Homo sapiens	17-20
32853879-5	2020	Notably, ME1 interference ultimately resulted in adaptive upregulation of mitochondrial IDH2 dependent of AMPK-FoxO1 activation to replenish the NADPH pool and mitigate cytosolic ROS.	ros	179-182	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	106-110
32816608-7	2020	Also, MACC1-AS1 overexpression obviously increased the levels of GLUT1, HK2, G6PD, MCT1, ATP, lactate and NAPDH as well as promoted the activities of HK2 and LDHA, while reduced ROS level and the ratio of NADP+/NAPDH.	ros	178-181	prostaglandin D2 receptor	Homo sapiens	12-15
32997407-12	2020	Sirt5-/- ADMSCs exhibited a higher proliferation rate, delayed senescence, and reduced ROS accumulation.	ros	87-90	sirtuin 5	Mus musculus	0-5
32736673-9	2020	Both in vivo and in vitro studies showed that inhibiting TREM-1 attenuated ROS accumulation, lipid per-oxidation (LPO) contents such as malondialdehyde (MDA) and enhanced the superoxide dismutase (SOD) activity after ischemia.	ros	75-78	triggering receptor expressed on myeloid cells 1	Rattus norvegicus	57-63
33061796-6	2020	The detrimental effects of UCP deletion were associated with increased ROS production, elevated mitochondrial fission markers Drp1 and Fis1 and suppressed fusion markers Opa1 and Mfn2 in UCP2-/- mice.	ros	71-74	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	27-30
32445748-7	2020	Possibly, FGF21 improves mitochondrial function, inhibits mitochondrial division, and reduces ROS production by maintaining mitochondrial dynamics and function to reduce NLRP3 related pyroptosis and inhibits VECs endoplasmic reticulum stress, thereby exerting an anti-atherosclerotic effect.	ros	94-97	fibroblast growth factor 21	Mus musculus	10-15
32417395-0	2020	IMPAD1 functions as mitochondrial electron transport inhibitor that prevents ROS production and promotes lung cancer metastasis through the AMPK-Notch1-HEY1 pathway.	ros	77-80	3'(2'), 5'-bisphosphate nucleotidase 2	Homo sapiens	0-6
32417395-8	2020	IMPAD1 caused mitochondria dysfunction by inhibiting mitochondrial Complex I activity, which reduced mitochondrial ROS levels and activated the AMPK-HEY1 pathway.	ros	115-118	3'(2'), 5'-bisphosphate nucleotidase 2	Homo sapiens	0-6
32729895-8	2020	Accordingly, CD133+CD44+ cells contained lower ROS levels than CD133-CD44- cells, and the low ROS levels in CD133+CD44+ cells were related to the enhancement of antioxidant defense systems.	ros	47-50	prominin 1	Homo sapiens	13-18
32417395-9	2020	Collectively this study supports the multipotent role of IMPAD1 in promotion of lung cancer metastasis by simultaneously increasing AMP levels, inhibition of Complex I activity to decrease ROS levels, thereby activating AMPK-Notch1-HEY1 signaling, and providing an alternative metabolic pathway in energy stress conditions.	ros	189-192	3'(2'), 5'-bisphosphate nucleotidase 2	Homo sapiens	57-63
32470830-9	2020	In addition, our data exhibit that both isobutyrylshikonin and shikonin induce caspase-dependent apoptosis via the mitochondrial pathway through accumulation of ROS in oral squamous carcinoma cells.	ros	161-164	caspase 8	Homo sapiens	79-86
32908936-6	2020	In addition, PRDX6 protected rat insulinoma RIN-m5F beta cells, cultured with TNF-alpha and IL-1beta, against the cytokine-induced cytotoxicity and reduced the apoptotic cell death and production of ROS.	ros	199-202	peroxiredoxin 6	Rattus norvegicus	13-18
32904047-0	2020	TiO2 Nanoparticles Caused DNA Damage in Lung and Extra-Pulmonary Organs Through ROS-Activated FOXO3a Signaling Pathway After Intratracheal Administration in Rats.	ros	80-83	forkhead box O3	Rattus norvegicus	94-100
31960283-10	2020	CONCLUSION: Cur, by quenching intra and extra mitochondrial ROS generation, rebalancing aconitase/fumarase and MDA/GSH ratios, and recoupling mitochondria, may support mithormesis priming and remitting in IBD.	ros	60-63	fumarate hydratase 1	Mus musculus	98-106
32824279-6	2020	Furthermore, an increase in ROS production was observed after the treatment with HO-AAVPA, which also could contribute to HMGB1 translocation.	ros	28-31	high mobility group box 1	Homo sapiens	122-127
32848720-8	2020	Moreover, our results demonstrated that 1alpha,25(OH)2D3 promoted the ROS level via activating NADPH oxidase complexes, NOX4, p22phox, and p47phox.	ros	70-73	NADPH oxidase 4	Mus musculus	120-124
32531281-6	2020	We show that MSL10 is required for several previously demonstrated responses to hypo-osmotic shock, including a cytoplasmic calcium transient within the first few seconds, accumulation of ROS within the first 30 min, and increased transcript levels of mechano-inducible genes within 60 min.	ros	188-191	mechanosensitive channel of small conductance-like 10	Arabidopsis thaliana	13-18
32598945-6	2020	Our findings in study I indicated that at post-thaw, an optimum 0.4 mg/mL k-CRG supplementation in the extender improved semen quality parameters, endogenous enzymes, MDA and ROS in comparison to the control group.	ros	175-178	chromodomain helicase DNA binding protein 7	Homo sapiens	76-79
32627814-0	2020	Expression of Concern: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS.	ros	112-115	NADPH oxidase 4	Homo sapiens	97-101
32575551-7	2020	The results indicated that CAT silencing promoted ROS production and apoptosis by up-regulating the Bcl-2-associated X protein (BAX) and Caspase-3 genes both at the transcriptional and translational levels.	ros	50-53	catalase	Bos taurus	27-30
32575551-7	2020	The results indicated that CAT silencing promoted ROS production and apoptosis by up-regulating the Bcl-2-associated X protein (BAX) and Caspase-3 genes both at the transcriptional and translational levels.	ros	50-53	caspase 3	Bos taurus	137-146
32416091-12	2020	Inhibition of ACE and AP-N resulted in suppressed cell proliferation; repressed IARP, AT1R, and MAS1 expression; elevated ROS production; and increased IL-1beta, TNF-alpha, and IL-6 levels in HK2 cells.	ros	122-125	alanyl aminopeptidase, membrane	Homo sapiens	22-26
32416091-14	2020	CONCLUSION: Suppression of ACE and AP-N expression mediates congenital UPJO pathogenesis by repressing renal tubular epithelial proliferation, promoting ROS production, and enhancing inflammatory factor expression.	ros	153-156	alanyl aminopeptidase, membrane	Homo sapiens	35-39
32554707-5	2020	Uremia inhibits Glut1-mediated uptake of glucose in neutrophils by causing aberrant activation of GSK3beta, resulting in reduced ROS generation and hence impaired killing of C. albicans in mice.	ros	129-132	glycogen synthase kinase 3 alpha	Homo sapiens	98-106
32669704-0	2020	Early modulation of macrophage ROS-PPARgamma-NF-kappaB signalling by sonodynamic therapy attenuates neointimal hyperplasia in rabbits.	ros	31-34	peroxisome proliferator-activated receptor gamma	Oryctolagus cuniculus	35-44
32821147-2	2020	P47phox is the most important subunit of an ROS-producing enzyme (NADPH oxidase) which is reportedly upregulated in MS plaques due to the intense activity of infiltrated immune cells and resident microglia.	ros	44-47	neutrophil cytosolic factor 1	Rattus norvegicus	0-7
32874469-12	2020	The exposure to hyperbaric oxygen at the pressure of 2.4 ATAand 98% oxygen wasable to produce ROS and RNS molecules, which play a role in cellular adaptive responses through increasing the expression of nfkb, p21 and mRNA of interferon alpha2 plays a role in inhibition mechanism of HIV-1 replication in cells.	ros	94-97	interferon alpha 2	Homo sapiens	225-242
32554707-6	2020	Consequently, pharmacological inhibition of GSK3beta restored glucose uptake and rescued ROS production and candidacidal function of neutrophils in uremic mice.	ros	89-92	glycogen synthase kinase 3 alpha	Mus musculus	44-52
32303578-8	2020	Ultrastructural analyses illustrated a significant increase of dysfunctional mitochondria in Angpt2-silenced tumor cells, thereby resulting in enhanced ROS production and downstream MAPK stress signaling.	ros	152-155	angiopoietin 2	Homo sapiens	93-99
32303578-9	2020	Functionally, enhanced ROS in Angpt2-silenced tumor cells reduced colonization potential in vitro and in vivo.	ros	23-26	angiopoietin 2	Homo sapiens	30-36
32468088-11	2020	The data indicated that PDCD4 played a regulatory role in ROS generation, which is reportedly involved in apoptosis.	ros	58-61	programmed cell death 4	Homo sapiens	24-29
32736659-10	2020	In addition, hBMSCs treated with 100 ng/ml HGF and 10 ng/ml SCF had reduced ROS levels and preserved mitochondrial membrane potential compared with P8 hBMSCs during long-term expansion.	ros	76-79	hepatocyte growth factor	Homo sapiens	43-46
32610494-7	2020	Our findings proved that genistein induced ROS production through upregulation of miR-34a, leading to apoptosis in HNC-TICs.	ros	43-46	microRNA 34a	Homo sapiens	82-89
32727098-7	2020	In addition, increased expression of miR-4516 by melatonin treatment reduced ROS formation and restored mitochondrial function.	ros	77-80	microRNA 4516	Homo sapiens	37-45
32610494-11	2020	These results suggested that genistein-induced miR-34a contributed to the ROS-associated apoptosis and diminished stemness properties via repression of RTCB in HNC-TICs.	ros	74-77	microRNA 34a	Homo sapiens	47-54
32383848-4	2020	By the enzymatic reactions of SOD and CAT, the interior of silica nanoreactors becomes a "ROS safe zone" to protect the glucose-dependent NADH production of co-encapsulated GDH.	ros	90-93	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	173-176
32513988-7	2020	ANRIL could act as a molecular scaffold to promote the binding of WDR5 and HDAC3 to form WDR5 and HDAC3 complexes, they regulated target genes such as NOX1 expression by histone modification, upregulated ROS level and promote HASMC phenotype transition.	ros	204-207	histone deacetylase 3	Homo sapiens	75-80
32513988-7	2020	ANRIL could act as a molecular scaffold to promote the binding of WDR5 and HDAC3 to form WDR5 and HDAC3 complexes, they regulated target genes such as NOX1 expression by histone modification, upregulated ROS level and promote HASMC phenotype transition.	ros	204-207	histone deacetylase 3	Homo sapiens	98-103
32317079-7	2020	Consistently, GPx7 overexpression in LX-2 cells led to the suppression of ROS production and reduced the expression of pro-fibrotic and pro-inflammatory genes.	ros	74-77	glutathione peroxidase 7	Homo sapiens	14-18
32774667-7	2020	Then, we detected whether dexmedetomidine could downregulate Cx43 expression and its downstream PKC-alpha/NOX2/ROS signaling pathway activation and ultimately result in the decrease of U937-HUVEC adhesion.	ros	111-114	gap junction protein alpha 1	Homo sapiens	61-65
32289481-0	2020	Oroxylin a promotes PGC-1alpha/Mfn2 signaling to attenuate hepatocyte pyroptosis via blocking mitochondrial ROS in alcoholic liver disease.	ros	108-111	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	20-30
32289481-8	2020	Furthermore, oroxylin A upregulated mitofusin 2 (Mfn2) to resist lipid deposition and mitochondria-derived ROS overproduction.	ros	107-110	mitofusin 2	Mus musculus	36-47
32171159-9	2020	While the ROS scavenger NAC had effectively attenuated the ROS level and suppressed the TGF-beta1/Smad3 signaling pathway.	ros	10-13	transforming growth factor, beta 1	Mus musculus	88-97
32774667-10	2020	With the downregulation of Cx43 expression, the activity of PKC-alpha and its related NOX2/ROS signaling pathway were reduced.	ros	91-94	gap junction protein alpha 1	Homo sapiens	27-31
32171159-9	2020	While the ROS scavenger NAC had effectively attenuated the ROS level and suppressed the TGF-beta1/Smad3 signaling pathway.	ros	10-13	SMAD family member 3	Mus musculus	98-103
32289481-8	2020	Furthermore, oroxylin A upregulated mitofusin 2 (Mfn2) to resist lipid deposition and mitochondria-derived ROS overproduction.	ros	107-110	mitofusin 2	Mus musculus	49-53
32576206-0	2020	Mitochondrial ROS accumulation inhibiting JAK2/STAT3 pathway is a critical modulator of CYT997-induced autophagy and apoptosis in gastric cancer.	ros	14-17	Janus kinase 2	Homo sapiens	42-46
32171159-10	2020	Taken together, our results demonstrated combined exposure to PM2.5 and HFD could aggravate cardiac fibrosis via activating the ROS/TGF-beta1/Smad3 signaling pathway.	ros	128-131	transforming growth factor, beta 1	Mus musculus	132-141
32171159-10	2020	Taken together, our results demonstrated combined exposure to PM2.5 and HFD could aggravate cardiac fibrosis via activating the ROS/TGF-beta1/Smad3 signaling pathway.	ros	128-131	SMAD family member 3	Mus musculus	142-147
32576206-13	2020	CONCLUSIONS: CYT997 induces autophagy and apoptosis in gastric cancer by triggering mitochondrial ROS accumulation to silence JAK2/STAT3 pathway.	ros	98-101	Janus kinase 2	Homo sapiens	126-130
32587469-10	2020	PFD reduced hypoxia-induced phosphorylation of p38 through the NOX4/reactive oxygen species (ROS) signaling pathway.	ros	93-96	NADPH oxidase 4	Homo sapiens	63-67
32222636-8	2020	Meanwhile, I/R- and H/R-elevated inflammation, apoptosis and ROS were also alleviated by SH2B1 up-regulation.	ros	61-64	SH2B adaptor protein 1	Homo sapiens	89-94
32496208-0	2020	Ursolic acid reverses liver fibrosis by inhibiting interactive NOX4/ROS and RhoA/ROCK1 signalling pathways.	ros	68-71	NADPH oxidase 4	Mus musculus	63-67
32516132-9	2020	CLU-silenced OA chondrocytes showed higher MMP13 and COL10A1 as well as greater TNF-alpha, Nox4 and ROS levels.	ros	100-103	clusterin	Homo sapiens	0-3
32496208-12	2020	UA can reverse liver fibrosis by inhibiting the NOX4/ROS and RhoA/ROCK1 signalling pathways, which may interact with each other.	ros	53-56	NADPH oxidase 4	Mus musculus	48-52
32387808-5	2020	Complement and coagulation cascade, nitrogen metabolism, negative regulation of peptidase activity, and response to ROS were among the biological processes and pathways perturbed by the ETX exposure.	ros	116-119	pCP8533etx_p28	Clostridium perfringens	186-189
32222636-11	2020	CONCLUSION: Therefore, SH2B1 prevents cardiomyocytes from inflammation, apoptosis and ROS in MIRI partially through the PI3K/AKT-dependent avenues.	ros	86-89	SH2B adaptor protein 1	Homo sapiens	23-28
32483169-5	2020	Using different NADPH oxidase-deficient mice, we show that TSPO is a key regulator of NOX1-dependent neurotoxic ROS production in the retina.	ros	112-115	NADPH oxidase 1	Mus musculus	86-90
32547023-9	2020	AgNP treatment also increased the Bax, Bik, and Bim protein levels as well as NOX4-dependent ROS generation.	ros	93-96	NADPH oxidase 4	Homo sapiens	78-82
32179110-5	2020	After that, QDs-induced excessive ROS generation triggered the NLRP3 inflammasome activation and resulted in active caspase-1 to process pro-IL-1ss into mature IL-1ss release and inflammatory cell death, i.e. pyroptosis.	ros	34-37	caspase 1	Mus musculus	116-125
32547023-10	2020	However, T. gondii-infected ARPE-19 cells inhibited AgNP-induced apoptosis, JNK phosphorylation, sub-G1 phase cell accumulation, autophagy, NOX4-mediated ROS production, and mitochondrial apoptosis.	ros	154-157	NADPH oxidase 4	Homo sapiens	140-144
32547023-11	2020	Furthermore, mitochondrial apoptosis was found in AgNP-treated HFF cells and BMDMs, and AgNP-induced mitochondrial apoptosis inhibition via NOX4-dependent ROS suppression in T. gondii pre-infected HFF cells and BMDMs was also confirmed.	ros	155-158	NADPH oxidase 4	Homo sapiens	140-144
32547023-12	2020	Conclusion: AgNPs induced mitochondrial apoptosis in human RPE cells combined with cell cycle dysregulation and autophagy; however, these effects were significantly inhibited by T. gondii pre-infection by suppression of NOX4-mediated ROS production, suggesting that T. gondii is a strong inhibitory modulator of nanotoxicity in in vitro models.	ros	234-237	NADPH oxidase 4	Homo sapiens	220-224
32145302-9	2020	Our search for an inhibitor of NEIL2 revealed that vitamin B6, i.e., pyridoxine (PN), hinders NEIL2-mediated transcription-coupled repair process by not only decreasing NEIL2 expression but also inhibiting its association with RNA Pol II, thus stimulating DNA damage and triggering ROS.	ros	282-285	nei like DNA glycosylase 2	Homo sapiens	31-36
32145302-9	2020	Our search for an inhibitor of NEIL2 revealed that vitamin B6, i.e., pyridoxine (PN), hinders NEIL2-mediated transcription-coupled repair process by not only decreasing NEIL2 expression but also inhibiting its association with RNA Pol II, thus stimulating DNA damage and triggering ROS.	ros	282-285	nei like DNA glycosylase 2	Homo sapiens	94-99
32373191-8	2020	Additionally, melatonin-induced upregulation of Sestrin2 blocked apoptosis by preventing excessive ROS generation.	ros	99-102	sestrin 2	Rattus norvegicus	48-56
32373191-9	2020	The results demonstrated that melatonin controlled VSMC proliferation and apoptosis via Sestrin2-mediated inhibition of mTORC1 and ROS scavenging.	ros	131-134	sestrin 2	Rattus norvegicus	88-96
32378287-8	2020	In addition, the inhibition of ROS by NAC partially reversed the damage of TAK1 in vitro.	ros	31-34	mitogen-activated protein kinase kinase kinase 7	Mus musculus	75-79
32378287-9	2020	Our study presents the first direct evidence that inhibition of TAK1 mitigated MI/R injury, and TAK1 mediated ROS/ER stress/apoptosis signal pathway is important for the pathogenesis of MI/R injury.	ros	110-113	mitogen-activated protein kinase kinase kinase 7	Mus musculus	96-100
32547417-10	2020	Because higher oxidative phosphorylation can lead to higher ROS production, we tested if ROS affected the expression of AmelX and Enam genes that are essential for enamel formation.	ros	89-92	amelogenin, X-linked	Rattus norvegicus	120-125
32232334-1	2020	Previously, we have shown that human sperm Prohibitin (PHB) expression is significantly negatively correlated with mitochondrial ROS levels but positively correlated with mitochondrial membrane potential and motility.	ros	129-132	prohibitin 1	Homo sapiens	43-53
32547417-11	2020	The ameloblast cell line LS8 treated with H2O2 to promote ROS elicited significant expression changes in AmelX and Enam.	ros	58-61	amelogenin, X-linked	Rattus norvegicus	105-110
32547023-0	2020	Silver Nanoparticle-Induced Apoptosis in ARPE-19 Cells Is Inhibited by Toxoplasma gondii Pre-Infection Through Suppression of NOX4-Dependent ROS Generation.	ros	141-144	NADPH oxidase 4	Homo sapiens	126-130
32444628-7	2020	In addition, p38 activation along with an increase in basal ROS levels were found in Spry1KO clones compared to parental CM cell lines, suggesting that BRAFV600-mutant CM may restrain the activity of Spry1 to avoid oncogenic stress and to enable tumor growth.	ros	60-63	sprouty RTK signaling antagonist 1	Homo sapiens	85-90
32145302-9	2020	Our search for an inhibitor of NEIL2 revealed that vitamin B6, i.e., pyridoxine (PN), hinders NEIL2-mediated transcription-coupled repair process by not only decreasing NEIL2 expression but also inhibiting its association with RNA Pol II, thus stimulating DNA damage and triggering ROS.	ros	282-285	nei like DNA glycosylase 2	Homo sapiens	94-99
32509171-10	2020	In addition, it was demonstrated that Cav-1 promoted ROS generation via the activation of Rac1-dependent NADPH oxidase (NOX).	ros	53-56	Rac family small GTPase 1	Rattus norvegicus	90-94
32232334-1	2020	Previously, we have shown that human sperm Prohibitin (PHB) expression is significantly negatively correlated with mitochondrial ROS levels but positively correlated with mitochondrial membrane potential and motility.	ros	129-132	prohibitin 1	Homo sapiens	55-58
32670550-0	2020	beta-Escin alleviates cobalt chloride-induced hypoxia-mediated apoptotic resistance and invasion via ROS-dependent HIF-1alpha/TGF-beta/MMPs in A549 cells.	ros	101-104	transforming growth factor alpha	Homo sapiens	126-134
32444628-7	2020	In addition, p38 activation along with an increase in basal ROS levels were found in Spry1KO clones compared to parental CM cell lines, suggesting that BRAFV600-mutant CM may restrain the activity of Spry1 to avoid oncogenic stress and to enable tumor growth.	ros	60-63	sprouty RTK signaling antagonist 1	Homo sapiens	200-205
32268176-2	2020	Metallo-proteinases (MMPs) regulate numerous protein activities both in physiological and pathological conditions but their interplay with NOX2 and ROS formation is still unclear.	ros	148-151	matrix metallopeptidase 2	Homo sapiens	21-25
32508629-10	2020	Taken together, the results reveal that TLB effectively protects against Abeta25-35-induced neuronal cell death via activating ROS/p38/caspase 3-dependent pathway.	ros	127-130	mitogen-activated protein kinase 14	Mus musculus	131-134
32268176-10	2020	The study provides the first evidence that MMP2 has a key role in blunting platelet NOX2 activity and eventually ROS formation.	ros	113-116	matrix metallopeptidase 2	Homo sapiens	43-47
32397116-0	2020	Role of Endoplasmic Reticulum Stress Sensor IRE1alpha in Cellular Physiology, Calcium, ROS Signaling, and Metaflammation.	ros	87-90	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	44-53
32382077-0	2020	CRIF1 overexpression facilitates tumor growth and metastasis through inducing ROS/NFkappaB pathway in hepatocellular carcinoma.	ros	78-81	GADD45G interacting protein 1	Homo sapiens	0-5
32382077-6	2020	Mechanistically, increased mitochondrial ROS production and consequently activation of the NFkappaB signaling pathway was found to be involved in the promotion of growth and metastasis by CRIF1 in HCC cells.	ros	41-44	GADD45G interacting protein 1	Homo sapiens	188-193
32382077-7	2020	In summary, CRIF1 plays an oncogenic role in HCC progression through activating ROS/NFKB pathway, implying CRIF1 as a potential prognostic factor and therapeutic target in HCC.	ros	80-83	GADD45G interacting protein 1	Homo sapiens	12-17
32382077-7	2020	In summary, CRIF1 plays an oncogenic role in HCC progression through activating ROS/NFKB pathway, implying CRIF1 as a potential prognostic factor and therapeutic target in HCC.	ros	80-83	GADD45G interacting protein 1	Homo sapiens	107-112
32386538-2	2020	(2020) report in this issue of Molecular Cell that a paternal low-protein diet elevates ROS in the testicular germ cells, altering ATF7 activity and H3K9me2 abundance on target genes, including tRNA loci.	ros	88-91	activating transcription factor 7	Homo sapiens	131-135
32162090-7	2020	The increased gsh2 expression contributes to enhanced cellular glutathione content, and consequently alleviates ROS accumulation, lipid peroxidation, and cell membrane damage caused by 2-PE toxicity.	ros	112-115	glutathione synthase	Saccharomyces cerevisiae S288C	14-18
32143149-0	2020	Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production.	ros	105-108	SMAD family member 3	Mus musculus	0-5
32143149-0	2020	Smad3 promotes AKI sensitivity in diabetic mice via interaction with p53 and induction of NOX4-dependent ROS production.	ros	105-108	NADPH oxidase 4	Mus musculus	90-94
32143149-9	2020	Additionally, ChIP assay showed that Smad3 bound with the promoter region of NOX4 and induced ROS production and inflammation.	ros	94-97	SMAD family member 3	Mus musculus	37-42
32143149-9	2020	Additionally, ChIP assay showed that Smad3 bound with the promoter region of NOX4 and induced ROS production and inflammation.	ros	94-97	NADPH oxidase 4	Mus musculus	77-81
32062081-11	2020	Furthermore, intracellular ROS levels and p38 MAPK signalling activation were significantly increased in HRGECs and reducing ROS generation significantly abolished M1 macrophage-mediated endothelial senescence and p38 MAPK activation, suggesting that M1 macrophage-mediated endothelial senescence is largely dependent on ROS.	ros	125-128	mitogen-activated protein kinase 14	Mus musculus	214-222
32062081-11	2020	Furthermore, intracellular ROS levels and p38 MAPK signalling activation were significantly increased in HRGECs and reducing ROS generation significantly abolished M1 macrophage-mediated endothelial senescence and p38 MAPK activation, suggesting that M1 macrophage-mediated endothelial senescence is largely dependent on ROS.	ros	125-128	mitogen-activated protein kinase 14	Mus musculus	214-222
32577056-3	2020	S-protein of the virus was binding to ACE2 receptors caused downregulation of endogenous anti-viral mediators, upregulation of NF-kappaB pathway, ROS and pro-apoptotic protein.	ros	146-149	angiotensin converting enzyme 2	Homo sapiens	38-42
32355778-13	2020	Results: After the STC2 knockdown, MSCs increased ROS generation and cell apoptosis after PX12 pretreatment.	ros	50-53	stanniocalcin 2	Mus musculus	19-23
32454932-8	2020	Furthermore, we found that CpG ODN enhanced phosphorylation of ERK1/2 and Akt to inhibit ROS production.	ros	89-92	mitogen-activated protein kinase 3	Mus musculus	63-69
32122909-5	2020	We then examined the potential for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in many human cancers, and compared this with TGFbeta1 inhibition, a key regulator of the CAF phenotype.	ros	66-69	NADPH oxidase 4	Homo sapiens	87-91
32122909-5	2020	We then examined the potential for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in many human cancers, and compared this with TGFbeta1 inhibition, a key regulator of the CAF phenotype.	ros	66-69	lysine acetyltransferase 2B	Homo sapiens	117-120
32122909-5	2020	We then examined the potential for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in many human cancers, and compared this with TGFbeta1 inhibition, a key regulator of the CAF phenotype.	ros	66-69	lysine acetyltransferase 2B	Homo sapiens	117-120
32169612-3	2020	Results indicate the ROS accumulation in OSCC patients is accompanied by several changes including increase in mitochondrial mass, expression of mitochondrial fission protein (Drp1) and alteration in apoptotic signaling.	ros	21-24	collapsin response mediator protein 1	Homo sapiens	176-180
32368147-11	2020	Moreover, DLX6-AS1 knockdown suppressed TRPC3-mediated mitochondrial calcium uptake and ROS production.	ros	88-91	prostaglandin D2 receptor	Homo sapiens	15-18
32368147-11	2020	Moreover, DLX6-AS1 knockdown suppressed TRPC3-mediated mitochondrial calcium uptake and ROS production.	ros	88-91	transient receptor potential cation channel subfamily C member 3	Homo sapiens	40-45
32182906-7	2020	The second user case briefly describes a software architecture integrating state-of-art sensory devices, deep learning perceptual modules, and a ROS -based humanoid robot to enable IoT-aided HRI in a public space.	ros	145-148	eukaryotic translation initiation factor 2 alpha kinase 1	Homo sapiens	191-194
32072445-3	2020	GSK2795039 was reported to target NOX2 to inhibit [Formula: see text] and ROS production.	ros	74-77	cytochrome b-245, beta polypeptide	Mus musculus	34-38
31476315-0	2020	Metastatic melanoma cells rely on Sestrin2 to acquire anoikis resistance via detoxifying intracellular ROS.	ros	103-106	sestrin 2	Homo sapiens	34-42
32092796-0	2020	Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer"s Disease.	ros	82-85	microRNA 34c	Mus musculus	10-17
32100973-4	2020	We previously found that in Saccharomyces cerevisiae, two mutations in ATP synthase subunit a (atp6-P163S and atp6-K90E, equivalent to those detected in prostate and thyroid cancer samples, respectively) in the OM45-GFP background affected ROS and calcium homeostasis and delayed yeast PTP (yPTP) induction upon calcium treatment by modulating the dynamics of ATP synthase dimer/oligomer formation.	ros	240-243	F1F0 ATP synthase subunit a	Saccharomyces cerevisiae S288C	95-99
32092796-12	2020	These results indicated that increased miR-34c mediated synaptic and memory deficits by targeting SYT1 through ROS-JNK-p53 pathway and the miR-34c/SYT1 pathway could be considered as a promising novel therapeutic target for patients with AD.	ros	111-114	synaptotagmin 1	Homo sapiens	98-102
31838230-7	2020	The production of ROS induced the activation of the PI3K/Akt signaling pathway, as the expression levels of PI3K, Akt and PDK1 were significantly elevated.	ros	18-21	pyruvate dehydrogenase kinase 1	Gallus gallus	122-126
31887381-9	2020	In vivo, Rap-1 decreased the ROS and O2- levels and recovered the heart in zebrafish (Danio rerio) larvae induced by LPS, These results together suggested that Rap-1 could be a potential functional resource to protect against inflammatory and oxidative damage.	ros	29-32	RAS-related protein 1a	Mus musculus	9-14
31887381-9	2020	In vivo, Rap-1 decreased the ROS and O2- levels and recovered the heart in zebrafish (Danio rerio) larvae induced by LPS, These results together suggested that Rap-1 could be a potential functional resource to protect against inflammatory and oxidative damage.	ros	29-32	RAS-related protein 1a	Mus musculus	160-165
32114413-7	2020	In addition, the generation of ROS and the expression of NADHP oxidase 4 (NOX4) in the renal cortex were significantly reduced by Rg1 treatment.	ros	31-34	protein phosphatase 1, regulatory subunit 3A	Mus musculus	130-133
32033504-9	2020	ROS and p38 MAPK signaling pathways were involved in CB1-mediated neutrophil function, and ROS was upstream of p38 MAPK.	ros	91-94	mitogen-activated protein kinase 14	Mus musculus	111-119
31647138-4	2020	We established that CBD inhibited a mechanism involving, sequentially, NADPH oxidase-mediated ROS production and NF-kappaB-dependent signaling events.	ros	94-97	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	71-76
31647138-9	2020	Interestingly, CBD and 2-DG, as well as apocynin and TPCA-1 caused a reduction in glucose-derived NADPH, a cofactor required for NADPH oxidase activation and ROS generation.	ros	158-161	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	98-103
32114413-9	2020	These results suggested that Rg1 could delay kidney aging and inhibit aging-related glomerular fibrosis by reducing NOX4-derived ROS generation and downregulating NLRP3 inflammasome expression.	ros	129-132	protein phosphatase 1, regulatory subunit 3A	Mus musculus	29-32
32033504-9	2020	ROS and p38 MAPK signaling pathways were involved in CB1-mediated neutrophil function, and ROS was upstream of p38 MAPK.	ros	0-3	cannabinoid receptor 1 (brain)	Mus musculus	53-56
32033504-11	2020	Taken together, CB1 mediates neutrophil chemotaxis and NETosis via Galphai/o/ROS/p38 MAPK signaling pathway in liver inflammation, which represents an effective therapeutic strategy for liver diseases.	ros	77-80	cannabinoid receptor 1 (brain)	Mus musculus	16-19
32114413-9	2020	These results suggested that Rg1 could delay kidney aging and inhibit aging-related glomerular fibrosis by reducing NOX4-derived ROS generation and downregulating NLRP3 inflammasome expression.	ros	129-132	NADPH oxidase 4	Mus musculus	116-120
31672550-6	2020	When human umbilical vein endothelial cells (HUVECs) were exposed to oxidative stress, the level of TIPE1 was significantly up-regulated, and the ROS generation markedly increased in TIPE1 over-expressing HUVECs.	ros	146-149	TNF alpha induced protein 8 like 1	Homo sapiens	183-188
31919413-0	2020	GSK3beta is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ.	ros	35-38	glycogen synthase kinase 3 alpha	Homo sapiens	0-8
31919413-6	2020	Using the quinone DMNQ, a ROS generator, we demonstrate that GSK3beta is involved in the regulation of ROS-dependent necrosis.	ros	26-29	glycogen synthase kinase 3 alpha	Homo sapiens	61-69
31919413-6	2020	Using the quinone DMNQ, a ROS generator, we demonstrate that GSK3beta is involved in the regulation of ROS-dependent necrosis.	ros	103-106	glycogen synthase kinase 3 alpha	Homo sapiens	61-69
31919413-13	2020	In summary, GSK3beta by blunting the anti-oxidant response and particularly NQO1 and NQO2 expression, favors the appearance of necrosis in response to ROS, as generated by the quinone DMNQ.	ros	151-154	glycogen synthase kinase 3 alpha	Homo sapiens	12-20
31811866-0	2020	UCP2 promotes proliferation and chemoresistance through regulating the NF-kappaB/beta-catenin axis and mitochondrial ROS in gallbladder cancer.	ros	117-120	uncoupling protein 2	Homo sapiens	0-4
31811866-8	2020	UCP2 knockdown suppressed the activation of the NF-kappaB/beta-catenin axis and promoted the increases in mitochondrial ROS in gallbladder cancer cells exposed to gemcitabine treatments.	ros	120-123	uncoupling protein 2	Homo sapiens	0-4
31928662-6	2020	AOX1a overexpression resulted in the highest induction of AOX1A synthesis and MnSOD activity, and the lowest ROS level without pronounced changes in the phenotype relative to other genotypes.	ros	109-112	alternative oxidase 1A	Arabidopsis thaliana	0-5
31146669-2	2020	In hypertension, is well known the increase in ROS production, mainly by NADPH oxidases and xanthine oxidoreductase, among others, activated by a myriad of mechanisms.	ros	47-50	xanthine dehydrogenase	Homo sapiens	92-115
32329644-11	2020	It has also been elucidated that pre-treatment with NAC inhibited mitochondria-LC3B colocalization, where ROS acted as upstream of ERK1/2-p38 MAPKs activation.	ros	106-109	microtubule associated protein 1 light chain 3 beta	Homo sapiens	79-83
31816492-16	2020	CONCLUSION: This study demonstrates that ESAT6 bound with TLR2 can activate iNOS/NO and ROS signalings to reduce the trimethylation of H3K27 resulting in the increment of EMMMs expression that is beneficial to the transition of macrophages into epithelioid macrophages.	ros	88-91	toll-like receptor 2	Mus musculus	58-62
33132325-1	2020	Xanthine and hypoxanthine are intermediate metabolites of uric acid and a source of reactive oxidative species (ROS) by xanthine oxidoreductase (XOR), suggesting that facilitating their elimination is beneficial.	ros	112-115	xanthine dehydrogenase	Rattus norvegicus	145-148
33132325-10	2020	Accordingly, it is expected that treatment with XOR and URAT1 inhibitors will effectively decrease purine pools in the body and prevent cell injury due to ROS generated during XOR-mediated reactions.	ros	155-158	xanthine dehydrogenase	Rattus norvegicus	48-51
33132325-10	2020	Accordingly, it is expected that treatment with XOR and URAT1 inhibitors will effectively decrease purine pools in the body and prevent cell injury due to ROS generated during XOR-mediated reactions.	ros	155-158	xanthine dehydrogenase	Rattus norvegicus	176-179
31836542-7	2020	In vitro studies revealed that vitamin E TPGS/Apelin reduces hypoxia-induced mitochondrial ROS production in cultured cardiomyocytes and H9C2 cardiomyoblasts.	ros	91-94	apelin	Mus musculus	46-52
31722779-4	2019	Transduced Tat-CIAPIN1 significantly reduced ROS production and DNA fragmentation in LPS-exposed Raw 264.7 cells.	ros	45-48	tyrosine aminotransferase	Mus musculus	11-14
31336238-6	2019	The results showed that PM2.5 can induce cell death, ROS production and inflammatory cytokines release (IL-1beta, IL-18, TNF-alpha and COX-2) by activating TLR4/MyD88 pathway and NLRP3 inflammasome.	ros	53-56	toll like receptor 4	Sus scrofa	156-160
31336238-6	2019	The results showed that PM2.5 can induce cell death, ROS production and inflammatory cytokines release (IL-1beta, IL-18, TNF-alpha and COX-2) by activating TLR4/MyD88 pathway and NLRP3 inflammasome.	ros	53-56	MYD88 innate immune signal transduction adaptor	Sus scrofa	161-166
31841440-0	2019	Targeting CARD6 attenuates spinal cord injury (SCI) in mice through inhibiting apoptosis, inflammation and oxidative stress associated ROS production.	ros	135-138	caspase recruitment domain family, member 6	Mus musculus	10-15
31558022-2	2019	Here we demonstrate for the first time that carboxyl-modified polystyrene nanoparticles (CPS) could effectively inhibit ferroptosis as a result of reduced cellular ROS which was triggered by transcription factor EB (TFEB) nucleus translocation.	ros	164-167	transcription factor EB	Homo sapiens	216-220
31558022-6	2019	Then, TFEB-dependent enhanced expression of lysosomal proteins and superoxide dismutase (SOD) which ultimately led to ROS reduction and inhibition of ferroptosis.	ros	118-121	transcription factor EB	Homo sapiens	6-10
31558022-7	2019	Knockout of TFEB-enhanced ferroptosis was triggered by Erastin and abolished the effect of CPS on ROS and ferroptosis.	ros	98-101	transcription factor EB	Homo sapiens	12-16
31560934-5	2019	Mechanistically, activated MLKL targets mitochondria and triggers excessive generation of mitochondrial superoxide, which promotes AIF translocation into nucleus via causing mitochondrial depolarization and aggravates gamma-H2AX formation via improving intracellular accumulation of ROS.	ros	283-286	mixed lineage kinase domain like pseudokinase	Homo sapiens	27-31
31704983-9	2019	The ICH-induced increase in intracellular ROS, superoxide anion, and mROS generation and the decrease in adenosine triphosphate production were exacerbated in RNF34 transgenic mice, but NADPH oxidase activity was unaffected.	ros	42-45	ring finger protein 34	Mus musculus	159-164
31511637-0	2019	Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	ros	72-75	interleukin 1 receptor associated kinase 1	Homo sapiens	19-23
31301273-8	2019	The obtained data exhibited that inhibition of miR-137 or up-regulation of OXR1 ameliorated PD-induced oxidative stress injury, reduced pole-climbing time, but increased score for traction test as well as promoted viability and decreased apoptosis of neurons in PD model, accompanied with decreased MDA content and ROS levels, and increased SOD levels.	ros	315-318	microRNA 137	Mus musculus	47-54
31723205-2	2019	We recently reported that ras guanyl nucleotide releasing protein 2 (RasGRP2), which is a guanine nucleotide exchange factor, was expressed in the human umbilical vein endothelial cells (HUVECs) and that Rap1 activation by its overexpression inhibited apoptosis by suppressing tumor necrosis factor-alpha induced-reactive oxygen species (ROS) production.	ros	338-341	RAS guanyl releasing protein 2	Homo sapiens	26-67
31723205-2	2019	We recently reported that ras guanyl nucleotide releasing protein 2 (RasGRP2), which is a guanine nucleotide exchange factor, was expressed in the human umbilical vein endothelial cells (HUVECs) and that Rap1 activation by its overexpression inhibited apoptosis by suppressing tumor necrosis factor-alpha induced-reactive oxygen species (ROS) production.	ros	338-341	RAS guanyl releasing protein 2	Homo sapiens	69-76
31229705-10	2019	In addition, inhibiting JNK and ATM/ATR signaling pathways partially rescued the decrease in cell viability, indicating that abamectin-induced ROS overproduction and DNA damage might finally lead to cytotoxicity through JNK and ATM/ATR signaling pathways.	ros	143-146	ataxia telangiectasia mutated	Mus musculus	228-231
31511637-0	2019	Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	ros	72-75	neutrophil cytosolic factor 2	Homo sapiens	28-35
31703090-3	2019	We demonstrate that within this network, EPCR serves as a critical protective component as its deletion hypersensitizes primitive hematopoietic cells to pro-inflammatory signals and ROS accumulation resulting in compromised stem cell function.	ros	182-185	protein C receptor	Homo sapiens	41-45
31339188-4	2019	Palbociclib enhanced antioxidative enzyme generation and diminished ROS generation in hGL cells.	ros	68-71	LLGL scribble cell polarity complex component 2	Homo sapiens	86-89
31417181-9	2019	We demonstrated that the concomitant knockdown of four of these genes products, GPX2, GLRX, ALDH3A1, and PDK4, significantly increased ROS-dependent caspase activation, thus partially mimicking the consequences of NLUCAT1 inactivation in LUAD cells.	ros	135-138	glutaredoxin	Homo sapiens	86-90
31417181-9	2019	We demonstrated that the concomitant knockdown of four of these genes products, GPX2, GLRX, ALDH3A1, and PDK4, significantly increased ROS-dependent caspase activation, thus partially mimicking the consequences of NLUCAT1 inactivation in LUAD cells.	ros	135-138	aldehyde dehydrogenase 3 family member A1	Homo sapiens	92-99
31529536-6	2019	Further, lutein and oxidised lutein augmented the AMPK phosphorylation and activation of mitochondrion signalling molecule TFAM (protein expression) and mRNA expression of PGC-1alpha, TFAM, and NRF1 (responsible for mitochondria biogenesis) along with lowered ROS in HG compared to control and metformin groups.	ros	260-263	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	50-54
31396684-1	2019	KEY MESSAGE: Co-expression of Na+/H+ antiporter NHX1 and DEAD-box RNA helicase eIF4A1 from Arabidopsis positively regulates drought stress tolerance by improving ROS scavenging capacity and maintaining membrane integrity in sweetpotato.	ros	162-165	eukaryotic translation initiation factor 4A1	Arabidopsis thaliana	79-85
31368495-4	2019	Knockout of PUB4 resulted in the alteration of chitin-induced defense responses, indicating that PUB4 positively regulates ROS generation and callose deposition but negatively regulates MAPK activation and defense gene expression.	ros	123-126	RING/U-box superfamily protein with ARM repeat domain-containing protein	Arabidopsis thaliana	12-16
31368495-4	2019	Knockout of PUB4 resulted in the alteration of chitin-induced defense responses, indicating that PUB4 positively regulates ROS generation and callose deposition but negatively regulates MAPK activation and defense gene expression.	ros	123-126	RING/U-box superfamily protein with ARM repeat domain-containing protein	Arabidopsis thaliana	97-101
31295380-6	2019	Accordingly, in vitro studies revealed that Dpp3 KO osteoclasts had an inherent increased resorptive activity and ROS production, which on the other hand made them prone to apoptosis.	ros	114-117	dipeptidyl peptidase 3	Homo sapiens	44-48
31251109-7	2019	Zebrafish lacking Nipsnap1 show decreased mitophagy in the brain coupled with increased ROS production, loss of dopaminergic neurons and strongly reduced locomotion.	ros	88-91	nipsnap homolog 1 (C. elegans)	Danio rerio	18-26
31445075-9	2019	Co-exposure with mito-TEMPO (mitochondrial-specific ROS scavenger) for 24 h prevented ATP and GSH depletion, as well as the increases in H2O2 and caspase 3/7 activity observed with sunitinib.	ros	52-55	caspase 3	Rattus norvegicus	146-155
30982974-11	2019	Furthermore, ROS inhibitor N-acetyl-L-cysteine (NAC) also suppressed BaP co-exposure-induced expression of epithelial TSLP, IL-33, and IL-25.	ros	13-16	thymic stromal lymphopoietin	Mus musculus	118-122
31781342-9	2019	Silencing of AW112010 decreased the ATP level, mitochondrial membrane potential, and cell viability and increased mitochondrial ROS generation under oxidative stress in HEI-OC1 cells.	ros	128-131	expressed sequence AW112010	Mus musculus	13-21
31421823-6	2019	After UVB irradiation, treatments with NSC-CM and its secreted factors TIMP-1 and TIMP-2, markedly ameliorated the photodamage triggered by the increase in MMP expression and activity through ROS production, and the subsequent activation of the NF-kappaB pathway in UVB-irradiated fibroblasts and the treatment mouse group.	ros	192-195	tissue inhibitor of metalloproteinase 2	Mus musculus	82-88
30982974-11	2019	Furthermore, ROS inhibitor N-acetyl-L-cysteine (NAC) also suppressed BaP co-exposure-induced expression of epithelial TSLP, IL-33, and IL-25.	ros	13-16	interleukin 25	Mus musculus	135-140
31216372-4	2019	Here, we assess the ability of NLC derived from ER-HoxB8 progenitors to produce ROS and to perform chemotaxis and phagocytosis.	ros	80-83	homeobox B8	Mus musculus	51-56
31426130-12	2019	Our study revealed that the ROS derived from GEM promoted HK2 dimerization combining with voltage-dependent anion channel, which resulted in the resistance to GEM.	ros	28-31	hexokinase 2	Homo sapiens	58-61
31220321-3	2019	Here, we investigated OXTR methylation and its association with clinical and brain network connectivity phenotypes of negative symptoms, particularly anhedonia-asociality, in individuals with recent-onset schizophrenia (ROS) and at ultrahigh risk (UHR) for psychosis.	ros	220-223	oxytocin receptor	Homo sapiens	22-26
31326389-3	2019	In HUVECs (human umbilical vein endothelial cells), overexpression of NEDD4 reduced Ang II-induced ROS level and cell apoptosis.	ros	99-102	angiogenin	Homo sapiens	84-87
31332466-8	2019	Inhibition of OGA by bisphenol analogues further induced intracellular calcium, ROS, inflammation, repressed proliferation, interfered with cell cycle, induced apoptosis.	ros	80-83	O-GlcNAcase	Rattus norvegicus	14-17
31220321-7	2019	Both men and women with ROS and UHR showed significantly decreased OXTR methylation compared to HCs.	ros	24-27	oxytocin receptor	Homo sapiens	67-71
31305205-9	2019	Furthermore, exosomes from ox-LDL-treated MALAT1-overexpressing-HUVECs (ox-LDL-HUVECs-ExosLv-MALAT1) released elevated expression of MALAT1 to iDCs, which interacted with NRF2 and activated NRF2 signaling, and thereby inhibited ROS accumulation and DCs maturation.	ros	228-231	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	42-48
31305205-9	2019	Furthermore, exosomes from ox-LDL-treated MALAT1-overexpressing-HUVECs (ox-LDL-HUVECs-ExosLv-MALAT1) released elevated expression of MALAT1 to iDCs, which interacted with NRF2 and activated NRF2 signaling, and thereby inhibited ROS accumulation and DCs maturation.	ros	228-231	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	93-99
31220321-8	2019	In women with ROS and UHR, decreased OXTR methylation showed a significant correlation with increased anhedonia-asociality.	ros	14-17	oxytocin receptor	Homo sapiens	37-41
31305205-9	2019	Furthermore, exosomes from ox-LDL-treated MALAT1-overexpressing-HUVECs (ox-LDL-HUVECs-ExosLv-MALAT1) released elevated expression of MALAT1 to iDCs, which interacted with NRF2 and activated NRF2 signaling, and thereby inhibited ROS accumulation and DCs maturation.	ros	228-231	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	93-99
31254567-0	2019	ATPR-induced differentiation and G0/G1 phase arrest in acute promyelocytic leukemia by repressing EBP50/NCF1 complex to promote the production of ROS.	ros	146-149	SLC9A3 regulator 1	Homo sapiens	98-103
31254567-9	2019	Interestingly, the reduction of EBP50 contributed to ROS release by modulating the subcellular localization of NCF1.	ros	53-56	SLC9A3 regulator 1	Homo sapiens	32-37
31390228-0	2019	Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through AT1R/ROS/p38MAPK/ADAM17 pathway.	ros	122-125	angiotensin II receptor type 1	Homo sapiens	117-121
31390228-6	2019	Selective angiotensin II type 1 receptor (AT1R) blocker losartan suppressed ROS production and ROS scavenger N-Acetyl-L-cysteine (NAC) prevented p38 MAPK phosphorylation.	ros	76-79	angiotensin II receptor type 1	Homo sapiens	10-40
31487955-2	2019	Peroxisomal catalase gene expression decreases after pepper fruit ripening, while the enzyme is also susceptible to undergo post-translational modifications (nitration, S-nitrosation, and oxidation) promoted by reactive oxygen and nitrogen species (ROS/RNS).	ros	249-252	catalase	Bos taurus	12-20
31364822-9	2019	These results indicate that the p38 MAPK pathway might be involved downstream of ROS signaling as part of the mechanism of siphonodictyal B-induced apoptosis.	ros	81-84	mitogen-activated protein kinase 14	Mus musculus	32-35
31390228-6	2019	Selective angiotensin II type 1 receptor (AT1R) blocker losartan suppressed ROS production and ROS scavenger N-Acetyl-L-cysteine (NAC) prevented p38 MAPK phosphorylation.	ros	76-79	angiotensin II receptor type 1	Homo sapiens	42-46
31390228-6	2019	Selective angiotensin II type 1 receptor (AT1R) blocker losartan suppressed ROS production and ROS scavenger N-Acetyl-L-cysteine (NAC) prevented p38 MAPK phosphorylation.	ros	95-98	angiotensin II receptor type 1	Homo sapiens	10-40
31390228-6	2019	Selective angiotensin II type 1 receptor (AT1R) blocker losartan suppressed ROS production and ROS scavenger N-Acetyl-L-cysteine (NAC) prevented p38 MAPK phosphorylation.	ros	95-98	angiotensin II receptor type 1	Homo sapiens	42-46
31401084-8	2019	Interestingly, the basal level of ROS rises in DFF40 KO Jurkat cells, but ROS production levels after TBT exposure remains at the same basal level.	ros	34-37	DNA fragmentation factor subunit beta	Homo sapiens	47-52
31128248-7	2019	Mechanistically, SPHK2 suppressed LPS-triggered NF-kappaB activation independent of its catalytic activity and prevented increased mitochondrial ROS formation downstream of LPS.	ros	145-148	sphingosine kinase 2	Homo sapiens	17-22
31369811-8	2019	Moreover, its effects on NF-kappaB activation is dependent on the AMPK-PGC-1alpha-ROS axis, suggesting its potential use in osteolysis and other inflammation disorders.	ros	82-85	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	71-81
31351069-4	2019	While under normal conditions, a balance exists between oxidants and antioxidants, exposure to high glucose significantly increases the production of ROS, which is enhanced by NOX4 expression.	ros	150-153	NADPH oxidase 4	Homo sapiens	176-180
31473487-6	2019	The expression and activation of PGC-1alpha via the p38 MAPK was regulated by MCU-mediated mitochondrial calcium uptake, which is linked to increased mitochondrial ROS (mtROS) production.	ros	164-167	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	33-43
31473487-6	2019	The expression and activation of PGC-1alpha via the p38 MAPK was regulated by MCU-mediated mitochondrial calcium uptake, which is linked to increased mitochondrial ROS (mtROS) production.	ros	164-167	mitogen-activated protein kinase 14	Mus musculus	52-60
31473487-6	2019	The expression and activation of PGC-1alpha via the p38 MAPK was regulated by MCU-mediated mitochondrial calcium uptake, which is linked to increased mitochondrial ROS (mtROS) production.	ros	164-167	mitochondrial calcium uniporter	Mus musculus	78-81
31425146-3	2019	The correlation between decreased expression of Cav1.3 and age-related hearing losses was studied in vitro, after Cav1.3 was knocked out, the rate of apoptosis of hair cells increased after being subjected to ROS stresses, accompanied with enhanced senescence.	ros	209-212	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	48-54
31247190-8	2019	Moreover, SIRT5 decreases mitochondrial membrane potential (DeltaPsim), ATP products and increases the ROS levels and NADP/NADPH ratio in GC cells through the inhibition of OGDH complex activity.	ros	103-106	sirtuin 5	Homo sapiens	10-15
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	119-122	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	89-95
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	119-122	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31434799-6	2019	Mechanistically, NOX4 further augmented mitochondrial ROS production and induced mitochondrial biogenesis.	ros	54-57	NADPH oxidase 4	Mus musculus	17-21
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	119-122	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31132531-4	2019	Further mechanism study demonstrated EGPI-1 played an antitumor role in multiple modes of action including regulating the activity of eIF4E by inhibiting the phosphorylation of eIF4E and 4EBP1, disrupting mitochondrial function through the mTOR/4EBP1 signaling pathway, and inducing autophagy, apoptosis and ROS generation.	ros	308-311	eukaryotic translation initiation factor 4E	Homo sapiens	134-139
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	119-122	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	89-95
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	89-95
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31103463-5	2019	However, XDH/XO inhibition by specific small chemical inhibitors or gene silencing reduced total ROS levels and protected cells from apoptosis induced by Alternol.	ros	97-100	xanthine dehydrogenase	Homo sapiens	9-12
31103463-9	2019	Taken together, our data demonstrate that Alternol treatment enhances XDH oxidative activity, leading to ROS-dependent apoptotic cell death.	ros	105-108	xanthine dehydrogenase	Homo sapiens	70-73
31368573-8	2019	The findings of this study show that HFD-CO, and through the increasing generation of ROS and IL-6 levels and shedding, could activate LV JAK1/2-STAT1/3  and  renin-angiotensin system (RAS) signaling pathways, thus creating a positive feedback between the two which ultimately leads to activation of TGF-1beta/Smad3 fibrotic pathway.	ros	86-89	Janus kinase 1	Rattus norvegicus	138-144
31368573-8	2019	The findings of this study show that HFD-CO, and through the increasing generation of ROS and IL-6 levels and shedding, could activate LV JAK1/2-STAT1/3  and  renin-angiotensin system (RAS) signaling pathways, thus creating a positive feedback between the two which ultimately leads to activation of TGF-1beta/Smad3 fibrotic pathway.	ros	86-89	signal transducer and activator of transcription 1	Rattus norvegicus	145-152
31069623-12	2019	Graphical Abstract FTY720 may reduce ROS production by inhibiting the PI3K/AKT/GSK-3beta signaling pathway, while at the same time reducing p65 phosphorylation, thus decreasing NLRP3 inflammasome activation through these two pathways, ultimately reducing microglia activation-induced neuronal damage.	ros	37-40	glycogen synthase kinase 3 alpha	Mus musculus	79-88
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
31507536-8	2019	We conclude that during conditions of elevated Ang II, GPER via the cAMP pathway suppresses Nox4 transcription to limit ROS production and prevent arterial stiffening.	ros	120-123	NADPH oxidase 4	Mus musculus	92-96
31425146-6	2019	The effect was further confirmed in 3D organ culture, increased loss of hair cells after Cav1.3 was knocked down under ROS stresses.Mechanistically, Cav1.3 knock out resulted in decreased intracellular calcium which subsequently reduced the inactivation of ROS from complex I, and finally resulted in increased intracellular ROS and enhanced senescence.Collectively, these findings confirmed that Cav1.3 could protect cells in auditory pathway from oxidative stresses, and decreased expression of Cav1.3 in auditory pathway could contribute to hearing losses by enhancement of calcium-mediated oxidative stress.	ros	257-260	calcium channel, voltage-dependent, L type, alpha 1D subunit	Mus musculus	149-155
30608002-6	2019	Meanwhile, Rg1 reduced the excessive ROS and the occurrence of cell apoptosis, which were related to Nrf2/ARE pathway.	ros	37-40	protein phosphatase 1, regulatory subunit 3A	Mus musculus	11-14
31187398-7	2019	Mechanistically, melatonin significantly prevented CHP-induced activation of ERK1/2, JNK, and P38 MAPK at least by inhibiting ROS generation and enhancing the total antioxidant potential.	ros	126-129	mitogen activated protein kinase 3	Rattus norvegicus	77-83
31078114-7	2019	In addition, the suppression of NLRP3 inflammasome activation by UFL1 was partly mediated through the regulation of NF-kappaB signaling and ROS production.	ros	140-143	NLR family pyrin domain containing 3	Bos taurus	32-37
30930231-8	2019	The level of pro-inflammatory cytokine, as well as ROS and NO generation, were also increased when TGF-beta treated macrophages were subjected to C75 treatment.	ros	51-54	transforming growth factor, beta 1	Mus musculus	99-107
30963238-1	2019	KEY MESSAGE: The TPS5 negatively regulates ABA signaling by mediating ROS level and NR activity during seed germination and stomatal closure in Arabidopsis thaliana.	ros	70-73	trehalose phosphatase/synthase 5	Arabidopsis thaliana	17-21
31064654-9	2019	Furthermore, the over-expression of IDH2 in hepatocytes led to the suppression of ROS production and DRP1 expression, but the alleviation of dyslipidemia.	ros	82-85	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	36-40
31413213-13	2019	In the miR-30a high expression group treated by chemotherapeutics, the level of autophagy and the cell survival rate were lower than those in group with low expression of miR-30a, while the levels of ROS, the mitochondrial oxidative damage and the apoptosis were higher than those in group with low expression of miR-30a (all P&lt;0.05).	ros	200-203	microRNA 30a	Homo sapiens	7-14
31396093-7	2019	The lower NADPH oxidase activity in the kidney of RAP-treated mice compared to NaCl-treated mice suggests limited ROS production.	ros	114-117	low density lipoprotein receptor-related protein associated protein 1	Mus musculus	50-53
31367263-10	2019	This differential response might be due to IR induced MMP-2 distinctive ROS generation in HDFs and MCF-7 cells.	ros	72-75	matrix metallopeptidase 2	Homo sapiens	54-59
31320987-7	2019	The upregulation of LC3-II and NCOA4 from immunofluorescence and Western blotting analysis revealed that the occurrence of ferritinophagy contributed to ROS production.	ros	153-156	nuclear receptor coactivator 4	Mus musculus	31-36
31332209-2	2019	We found that as ROS and inflammation levels increased during aging, steroidogenic enzymes (StAR and P450scc) reduced and led to the decline of testosterone production eventually.	ros	17-20	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	101-108
31318905-6	2019	Silencing of Nox4 using Nox4 siRNA and pharmacologic inhibition with GKT137831 (a specific Nox1/4 inhibitor) reduced the production of ROS and attenuated the apoptotic pathway.	ros	135-138	NADPH oxidase 4	Homo sapiens	13-17
31216990-12	2019	CONCLUSION: SAA1-mediated NOX4/ROS pathway could activate p38MAPK/NF-kappaB pathway, thereby contributing to the release of inflammatory factors in LPS-induced VSMCs.	ros	31-34	NADPH oxidase 4	Homo sapiens	26-30
31318905-6	2019	Silencing of Nox4 using Nox4 siRNA and pharmacologic inhibition with GKT137831 (a specific Nox1/4 inhibitor) reduced the production of ROS and attenuated the apoptotic pathway.	ros	135-138	NADPH oxidase 1	Homo sapiens	91-97
31318905-8	2019	This study demonstrates that hypoxia induces HK-2 cell apoptosis through a signaling pathway involving TGF-beta1 via Smad pathway induction of Nox4-dependent ROS generation.	ros	158-161	hexokinase 2	Homo sapiens	45-49
31318905-8	2019	This study demonstrates that hypoxia induces HK-2 cell apoptosis through a signaling pathway involving TGF-beta1 via Smad pathway induction of Nox4-dependent ROS generation.	ros	158-161	NADPH oxidase 4	Homo sapiens	143-147
31160554-1	2019	Peroxiredoxin II (Prx II), an antioxidant enzyme in the Prx family, reduces oxidative stress by decreasing the intracellular ROS levels.	ros	125-128	peroxiredoxin 2	Mus musculus	0-16
31310624-4	2019	The results indicated that RSV-induced Rad9 expression, mediated by DNA damage and ROS, can significantly suppress proliferation by activating cellular senescence, and diminishing the expression of EMT markers with concomitant downregulation of Slug in breast and lung cancer cell lines.	ros	83-86	RAD9 checkpoint clamp component A	Homo sapiens	39-43
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	ros	4-7	cyclin dependent kinase 2	Homo sapiens	166-170
30954547-0	2019	The apoptosis and GLP-1 hyposecretion induced by LPS via RIP/ROS/mTOR pathway in GLUTag cells.	ros	61-64	glucagon	Mus musculus	18-23
31160554-1	2019	Peroxiredoxin II (Prx II), an antioxidant enzyme in the Prx family, reduces oxidative stress by decreasing the intracellular ROS levels.	ros	125-128	peroxiredoxin 2	Mus musculus	18-24
30658013-9	2019	Importantly, these effects of PGG were associated with improved vascular function and decreased ROS production in the aortas of Ang II-infused animals independently of the BP increase.	ros	96-99	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	128-131
30904435-11	2019	PSMB9 knockdown aggravated accumulation of alpha-syn, degradation of TH, release of ROS, increased level of MDA, decreased level of GSH and eventually promoted apoptosis in SH-SY5Y cells after rotenone treatment, while over-expression of PSMB9 could attenuate these toxic effects of rotenone.	ros	84-87	proteasome 20S subunit beta 9	Homo sapiens	0-5
30944975-5	2019	Additionally, different inhibitors of signaling pathways and ROS were used to evaluate their importance for MIF expression.	ros	61-64	macrophage migration inhibitory factor	Homo sapiens	108-111
32666016-4	2020	The NADPH oxidase Nox4 is a major source of ROS in bone.	ros	44-47	NADPH oxidase 4	Mus musculus	18-22
32666016-15	2020	Taken together, our findings suggest a novel link between CSF-1, Nox4-derived ROS, and osteocyte survival/function that is crucial for osteocyte-mediated bone remodeling.	ros	78-81	NADPH oxidase 4	Mus musculus	65-69
30944975-7	2019	RESULTS: We showed that RSV induces MIF expression dependently of ROS, 5-LOX, COX and PI3K activation.	ros	66-69	macrophage migration inhibitory factor	Homo sapiens	36-39
30952098-8	2019	In vitro, UCP2 overexpression protected HK-2 cells from LPS-induced injury by suppression of apoptosis, inflammation, oxidative stress, MMP loss and ROS production, increase of ATP production and mtDNA content, and amelioration of damage to the mitochondrial ultrastructure.	ros	149-152	uncoupling protein 2	Homo sapiens	10-14
31005256-4	2019	In vitro, knockdown of TRPV4 in macrophages reduces the levels of pro-inflammatory cytokines, ROS production, Ca2+ concentration in cytoplasma and the activation of calcineurin/NFATc3 signaling.	ros	94-97	transient receptor potential cation channel subfamily V member 4	Homo sapiens	23-28
30511378-5	2019	ROS 17/2.8 osteoblastic cells were stimulated with BMP2, together with GFCM.	ros	0-3	bone morphogenetic protein 2	Rattus norvegicus	51-55
30825547-5	2019	In line with the alleviated ROS levels, tambulin treatment led to upregulated mRNA expression of ROS scavenging genes viz., sod-1, sod-3, and ctl-2.	ros	97-100	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	131-136
30370641-7	2019	In vitro, Nrf2 activation attenuated TGF-beta1-induced EMT and ROS production accompanied by the downregulation of HMGB1.	ros	63-66	transforming growth factor, beta 1	Mus musculus	37-46
31118506-10	2019	These results suggest that Ang II-mediated MYH9 depletion in diabetic nephropathy may increase filtration barrier permeability by inducing structural and functional podocyte injury through TRPC6-mediated Ca2+ influx by NOX4-mediated ROS generation.	ros	233-236	NADPH oxidase 4	Homo sapiens	219-223
30415472-8	2019	Mechanistically, the survival advantage conferred by mtSSB was primarily caused by increased mitochondrial biogenesis and subsequent ROS production, which induced telomerase reverse transcriptase (TERT) expression and telomere elongation via Akt/mTOR pathway in CRC cells.	ros	133-136	single stranded DNA binding protein 1	Homo sapiens	53-58
31178965-0	2019	ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells.	ros	0-3	steroidogenic acute regulatory protein	Homo sapiens	52-56
31178965-8	2019	Elimination of LPS-stimulated ROS by melatonin or vitamin C could restore the expressions of GATA4, GATA6, and StAR.	ros	30-33	steroidogenic acute regulatory protein	Homo sapiens	111-115
31179339-9	2019	In conclusion, BSF can decrease proteinuria and protect podocytes from injury in DN, in part through inhibiting the NOX-4/ROS/p38 pathway.	ros	122-125	NADPH oxidase 4	Homo sapiens	116-121
31105999-5	2019	Erastin enhanced ROS levels, thereby promoting cytosolic translocation of HMGB1 and enhancing cell death.	ros	17-20	high mobility group box 1	Homo sapiens	74-79
31105999-6	2019	Knockdown of HMGB1 decreased erastin-induced ROS generation and cell death in an iron-mediated lysosomal pathway in HL-60/NRASQ61L cells.	ros	45-48	high mobility group box 1	Homo sapiens	13-18
30414389-5	2019	ABZ-induced SIRT3 degradation elicited ROS-mediated p38 MAPK activation, leading to pyruvate kinase M2-mediated tristetraprolin (TTP) degradation.	ros	39-42	ZFP36 ring finger protein	Homo sapiens	112-127
30414389-5	2019	ABZ-induced SIRT3 degradation elicited ROS-mediated p38 MAPK activation, leading to pyruvate kinase M2-mediated tristetraprolin (TTP) degradation.	ros	39-42	ZFP36 ring finger protein	Homo sapiens	129-132
30703374-0	2019	Irisin attenuates angiotensin II-induced cardiac fibrosis via Nrf2 mediated inhibition of ROS/ TGFbeta1/Smad2/3 signaling axis.	ros	90-93	transforming growth factor, beta 1	Mus musculus	95-103
30508540-8	2019	IFN-lambda1 stimulation increased intracellular killing of S aureus in THP1-derived macrophages and substantially increased lysosomal-associated membrane protein 1, IL-28R, ROS, and STAT signaling in macrophages incubated with S aureus.	ros	173-176	interferon lambda 1	Homo sapiens	0-11
30914692-9	2019	The production of intracellular ROS was significantly reduced in the presence of angiotensin II type1-receptor (AT1R) antagonist, whereas it was augmented in the presence of angiotensin II type2-receptor antagonist.	ros	32-35	angiotensin II receptor type 1	Homo sapiens	81-110
30948926-5	2019	Secondly, the influence of ROS content on the activity of the JNK1/Sirt1/FoxO3a signaling pathway was explored through the application of NAC, sp600125 (a JNK1 inhibitor), and nicotinamide (a Sirt1 inhibitor).	ros	27-30	forkhead box O3	Rattus norvegicus	73-79
30948926-9	2019	The changes of Cx43 channel function regulated ROS transfer between the neighboring cells, which mediated the activation of the JNK1/Sirt1/FoxO3a signaling pathway.	ros	47-50	forkhead box O3	Rattus norvegicus	139-145
30503790-6	2019	Furthermore, Salvianic acid A and Danshen granule significantly ameliorates Tat-induced intracellular ROS and MDA production, attenuates cell apoptosis.	ros	102-105	tyrosine aminotransferase	Homo sapiens	76-79
30264889-12	2019	Taken together, our current data suggest that LPS exposure during gestation could restrict the chondrocytes conversion from proliferating to hypertrophic in the growth plate, in which LPS-induced Sox9 plays a crucial role to trigger the cascade of downstream genes by excessive ROS production and Nrf2 elevation.	ros	278-281	SRY (sex determining region Y)-box 9	Mus musculus	196-200
30597356-7	2019	ERK1/2 inhibitor U0126 reduced ROS formation, the activation of NFkappaB and Egr1, and the elevated TNFalpha expression in D-glucose-stimulated BV2 cells.	ros	31-34	mitogen-activated protein kinase 3	Mus musculus	0-6
30710830-4	2019	Cyclooxygenase-2 (COX-2), as an inflammatory mediator is associated with ROS production with a NF-kappaB gene up regulation dependent manner in normal tissues.	ros	73-76	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
30710830-4	2019	Cyclooxygenase-2 (COX-2), as an inflammatory mediator is associated with ROS production with a NF-kappaB gene up regulation dependent manner in normal tissues.	ros	73-76	prostaglandin-endoperoxide synthase 2	Mus musculus	18-23
30814492-0	2019	Author Correction: Hypericin-mediated sonodynamic therapy induces autophagy and decreases lipids in THP-1 macrophage by promoting ROS-dependent nuclear translocation of TFEB.	ros	130-133	transcription factor EB	Homo sapiens	169-173
30837997-1	2019	Beta2-integrins are complex leukocyte-specific adhesion molecules that are essential for leukocyte (e.g., neutrophil, lymphocyte) trafficking, as well as for other immunological processes such as neutrophil phagocytosis and ROS production, and T cell activation.	ros	224-227	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	0-5
30744691-8	2019	DOC treatment significantly increased HMGB1 release in an ROS-dependent manner.	ros	58-61	high mobility group box 1	Homo sapiens	38-43
30709494-8	2019	In addition, less ROS accumulated in 35S:CsWRKY50 transgenic plants infected by the pathogen due to the higher expression levels of antioxidant enzymes.	ros	18-21	probable WRKY transcription factor 46-like	Cucumis sativus	41-49
30584981-0	2019	Particulate matter induces inflammatory cytokine production via activation of NFkappaB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin.	ros	100-103	NADPH oxidase 4	Homo sapiens	95-99
30584981-5	2019	Furthermore, PM2.5 induced a direct interaction between TLR5 and NOX4, and in turn induced the production of ROS and activated NFkappaB-IL-6 downstream, which was prevented by siRNA-mediated knockdown of NOX4 or antioxidant treatment.	ros	109-112	NADPH oxidase 4	Mus musculus	65-69
30584981-5	2019	Furthermore, PM2.5 induced a direct interaction between TLR5 and NOX4, and in turn induced the production of ROS and activated NFkappaB-IL-6 downstream, which was prevented by siRNA-mediated knockdown of NOX4 or antioxidant treatment.	ros	109-112	NADPH oxidase 4	Mus musculus	204-208
30593977-6	2019	However, the concomitant deletion of the SOD1 gene encoding the superoxide dismutase 1 resulted in a distinct phenotype: double deletion strains lacking SCO1 or SCO2 and SOD1 are highly sensitive to oxidative stress and show dramatically increased ROS levels.	ros	248-251	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	41-45
30989894-11	2019	After using AMPK siRNA that effects of catalpol on ROS overproduction and NOX4 protein expression inhibition were attenuated.	ros	51-54	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	12-16
31329158-8	2019	The clinical significance of Nox2-derived ROS in aging-related loss of cerebral capillaries and neurons was investigated using postmortem midbrain tissues of young (25-38 years) and elderly (61-85 years) adults.	ros	42-45	cytochrome b-245, beta polypeptide	Mus musculus	29-33
31337986-0	2019	YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway.	ros	118-121	Yes1 associated transcriptional regulator	Homo sapiens	0-3
31337986-9	2019	Mechanistically, YAP silencing significantly enhanced autophagic flux by increasing RAC1-driven ROS, which contributed to the inactivation of mTOR in HCC cells.	ros	96-99	Yes1 associated transcriptional regulator	Homo sapiens	17-20
31337986-11	2019	Conclusion: Our findings suggested that YAP upregulation endowed HCC cells with multi-drug resistance via the RAC1-ROS-mTOR pathway, resulting in the repression of autophagy-related cell death.	ros	115-118	Yes1 associated transcriptional regulator	Homo sapiens	40-43
31298304-11	2019	RESULTS: In the presence of high glucose, hRECs cells proliferation was significantly reduced, Caspase-3 activity was enhanced, LDH and ROS levels were increased, SOD activity was declined with increased expression of HMGB-1, NF-kappaB, VEGF, as well as secretion of TNF-alpha and IL-1beta compared with control group (p &lt; 0.05).	ros	136-139	high mobility group box 1	Homo sapiens	218-224
31281314-6	2019	Flow cytometry analysis showed equal phosphorylation of STAT3 but reduced ROS production that was associated with reduced nuclear translocation of the NF-kB p50 subunit in Sparc-/- than WT MDSC.	ros	74-77	secreted acidic cysteine rich glycoprotein	Mus musculus	172-177
30811525-3	2019	AREAS OF AGREEMENT: Five mechanisms were identified: arrest of proliferation through a decreased activity of cyclin B, CDK-1, CHK-1, and increased PK-1; decrease tenocytes migration through decreased phosphorylation of FAK; decrease type I collagen metabolism through increased MMP-2; chelate effect on ions that influence epigenetics and several enzymes; fluoroquinolones-induced ROS (radical oxygen species) production in mitochondria.	ros	381-384	protein tyrosine kinase 2	Homo sapiens	219-222
31099374-6	2019	In addition, PaH-PDT markedly increased the generation of intracellular ROS, which can be suppressed using the ROS scavenger N-acetylcysteine (NAC).	ros	72-75	phenylalanine hydroxylase	Homo sapiens	13-20
31099374-6	2019	In addition, PaH-PDT markedly increased the generation of intracellular ROS, which can be suppressed using the ROS scavenger N-acetylcysteine (NAC).	ros	111-114	phenylalanine hydroxylase	Homo sapiens	13-20
30953403-8	2019	At molecular level, both isoforms activate the autophagy/lysosome system, normally altered during aging, and increase PGC1-alpha expression, modulating mitochondrial function, ROS detoxification, and the basal inflammatory state occurring at old age.	ros	176-179	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	118-128
31060923-8	2019	There were large amounts of pro-apoptotic cytochrome c (Cytc) and cleaved caspase-9/3 proteins detected using western blot analysis after 30 days of spermatozoa storage at 4  C. These findings indicate ROS generation induces mitochondria damage after 20 days of storage at 4  C, which can induce spermatozoa apoptotic-like changes during storage of soft-shelled turtle spermatozoa.	ros	202-205	cytochrome c	Pelodiscus sinensis	42-54
31060923-8	2019	There were large amounts of pro-apoptotic cytochrome c (Cytc) and cleaved caspase-9/3 proteins detected using western blot analysis after 30 days of spermatozoa storage at 4  C. These findings indicate ROS generation induces mitochondria damage after 20 days of storage at 4  C, which can induce spermatozoa apoptotic-like changes during storage of soft-shelled turtle spermatozoa.	ros	202-205	cytochrome c	Pelodiscus sinensis	56-60
31017709-7	2019	Ghrelin induced ROS release and dose dependently reduced podocyte survival.	ros	16-19	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
31054074-4	2019	DJ-1 increases the expression of two mitochondrial uncoupling proteins (UCP 4 and UCP5), that decrease mitochondrial membrane potential and leads to the suppression of ROS production, optimizes of a number of mitochondrial functions, and is regarded as protection for the neuronal cell survival.	ros	168-171	solute carrier family 25 member 27	Homo sapiens	72-77
30370641-8	2019	In contrast, silencing Nrf2 enhanced TGF-beta1-induced EMT and ROS production along with increased the protein expression and the release of HMGB1.	ros	63-66	transforming growth factor, beta 1	Mus musculus	37-46
31191310-0	2019	Total Extracts of Abelmoschus manihot L. Attenuates Adriamycin-Induced Renal Tubule Injury via Suppression of ROS-ERK1/2-Mediated NLRP3 Inflammasome Activation.	ros	110-113	mitogen activated protein kinase 3	Rattus norvegicus	114-120
31191310-9	2019	Collectively, TEA protects renal tubular cells against Adriamycin-induced tubule injury via inhibition of ROS-ERK1/2-NLRP3 inflammasomes.	ros	106-109	mitogen activated protein kinase 3	Rattus norvegicus	110-116
31038133-8	2019	Collectively, our findings reveal that brosimone I induces cell cycle G1 phase arrest and apoptosis via the induction of ROS-mediated increased cytosolic Ca2+, ER stress, and the activation of the CaMKKbeta-AMPK signaling pathway.	ros	121-124	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	207-211
31118036-2	2019	The fusion gene SLC34A2-ROS1 (solute carrier family 34 member 2 and ROS proto-oncogene 1) plays an important role in non-small cell lung cancer (NSCLC) progression.	ros	24-27	solute carrier family 34 member 2	Homo sapiens	16-23
31118036-2	2019	The fusion gene SLC34A2-ROS1 (solute carrier family 34 member 2 and ROS proto-oncogene 1) plays an important role in non-small cell lung cancer (NSCLC) progression.	ros	24-27	solute carrier family 34 member 2	Homo sapiens	30-63
30952428-6	2019	Intriguingly, GRK2 knockdown reduced ROS generation.	ros	37-40	G protein-coupled receptor kinase 2	Rattus norvegicus	14-18
31249639-10	2019	In such a process, apolipoprotein E regulates NET formation via the ROS-MAPK-MSK1 pathway.	ros	68-71	ribosomal protein S6 kinase, polypeptide 5	Mus musculus	77-81
29426376-4	2019	Knockdown of NOX4 expression by siRNA inhibited glycolysis induced by hypoxia through decreasing the expression of glycolysis-related proteins (HIF-1alpha, LDHA, and PDK1), decreasing glucose uptake, lactate production, and ROS production, while increasing mitochondria membrane potential.	ros	224-227	NADPH oxidase 4	Homo sapiens	13-17
30870695-6	2019	Increases in intracellular ROS were observed along with higher levels of mRNA anti-oxidation markers SOD1, SOD2, and CAT.	ros	27-30	superoxide dismutase [Cu-Zn]	Bos taurus	101-105
30870695-6	2019	Increases in intracellular ROS were observed along with higher levels of mRNA anti-oxidation markers SOD1, SOD2, and CAT.	ros	27-30	superoxide dismutase 2, mitochondrial	Bos taurus	107-111
30870695-6	2019	Increases in intracellular ROS were observed along with higher levels of mRNA anti-oxidation markers SOD1, SOD2, and CAT.	ros	27-30	catalase	Bos taurus	117-120
30959745-8	2019	BNP in macrophages can stimulate ROS production, up-regulates IL-10, and inhibits IL-12 and TNF-alpha release by dendritic cells, suggesting an anti-inflammatory cytokines profile induction.	ros	33-36	natriuretic peptide B	Homo sapiens	0-3
30905847-6	2019	FINDINGS: We identified ROS-dependent inactivation of the tyrosine phosphatase SHP-2 to be decisive for endothelial activation in sepsis.	ros	24-27	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	79-84
30905847-8	2019	The impaired SHP-2 activity was restored by ROS inhibitors and an IL-1 receptor antagonist.	ros	44-47	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	13-18
30905847-12	2019	INTERPRETATION: Our data show that SHP-2 inactivation by ROS in sepsis releases a protective break, resulting in endothelial activation.	ros	57-60	protein tyrosine phosphatase, non-receptor type 11	Mus musculus	35-40
30643688-10	2019	Quantitative real-time PCR analysis showed that biofertilizer + SAP significantly down-regulated the expression levels of genes involved in ROS scavenging (TaCAT, CsCAT, TaAPX, and CsAPX2), ethylene biosynthesis (TaACO2, CsACO1, and CsACS1), stress response (TaDHN3, TaLEA, and CsLEA11), salicylic acid (TaPR1-1a and CsPR1-1a), and transcription activation (TaNAC2D and CsNAC35) in plants under drought stress.	ros	140-143	1-aminocyclopropane-1-carboxylate oxidase 4	Cucumis sativus	221-227
30643688-10	2019	Quantitative real-time PCR analysis showed that biofertilizer + SAP significantly down-regulated the expression levels of genes involved in ROS scavenging (TaCAT, CsCAT, TaAPX, and CsAPX2), ethylene biosynthesis (TaACO2, CsACO1, and CsACS1), stress response (TaDHN3, TaLEA, and CsLEA11), salicylic acid (TaPR1-1a and CsPR1-1a), and transcription activation (TaNAC2D and CsNAC35) in plants under drought stress.	ros	140-143	1-aminocyclopropane-1-carboxylate synthase CMA101	Cucumis sativus	233-239
30353496-4	2019	Mitochondrial transcription factor A (TFAM) creates a mitochondrial nucleoid structure around mtDNA, protecting it from mutation, inhibiting NFAT (ROS activator/hypertrophic stimulator), and transcriptionally activates Serca2a to decrease calcium mishandling.	ros	147-150	transcription factor A, mitochondrial	Mus musculus	38-42
30051353-9	2019	Mechanistic studies revealed that increase in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (NOX2)-dependent superoxide/reactive oxygen species (ROS) production plays a key role in both LPS- and DSP-4-elicited neurotoxicity.	ros	161-164	cytochrome b-245, beta polypeptide	Mus musculus	46-107
30051353-9	2019	Mechanistic studies revealed that increase in nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-2 (NOX2)-dependent superoxide/reactive oxygen species (ROS) production plays a key role in both LPS- and DSP-4-elicited neurotoxicity.	ros	161-164	cytochrome b-245, beta polypeptide	Mus musculus	109-113
30511378-9	2019	10 ng/ml BMP2 increased alkaline phosphatase expression in ROS cells by 41%.	ros	59-62	bone morphogenetic protein 2	Rattus norvegicus	9-13
31083670-5	2019	RESULTS: Knockdown of PTOV1 and PIN1 inhibited the cell proliferation, colony formation, migration, cell cycle, and induced nuclear condensation as well as ROS production.	ros	156-159	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	22-27
30926903-5	2019	FX11 treatment and LDHA knockdown suppressed migration and invasion through ROS generation, but this was partially reversed by the antioxidant N-acetylcysteine (NAC).	ros	76-79	lactate dehydrogenase A	Mus musculus	19-23
30816299-8	2019	In summary, we conclude that cold-priming of chloroplast-to-nucleus ROS signalling by transient post-stress induction of tAPX transcription is a strategy to modify cell signalling for some time without affecting the alertness for activation of cold acclimation responses.	ros	68-71	thylakoidal ascorbate peroxidase	Arabidopsis thaliana	121-125
30311029-9	2019	CONCLUSION: COX6B1 protected cardiomyocytes from hypoxia/reoxygenation injury by reducing ROS production and cell apoptosis, during which reduction of the release of cytochrome C from mitochondria to cytosol was involved.	ros	90-93	cytochrome c oxidase subunit VIb polypeptide 1, pseudogene 1	Rattus norvegicus	12-18
30849338-7	2019	The reverse effect of NAC on LC3beta expression revealed the ROS-responsibility in autophagy regulation of CKD myopathy.	ros	61-64	microtubule-associated protein 1 light chain 3 beta	Mus musculus	29-36
30920152-9	2019	In summary, our study demonstrates that PD synergised with 2-DG to enhance its anti-cancer efficacy by inhibiting the ROS/PI3K/AKT/HIF-1alpha/HK2 signalling axis, providing a potential anti-cancer strategy.	ros	118-121	hexokinase 2	Homo sapiens	142-145
30804330-2	2019	We previously reported that GLDC downregulation enhances hepatocellular carcinoma (HCC) progression and intrahepatic metastasis through decreasing ROS-mediated ubiquitination of cofilin.	ros	147-150	glycine decarboxylase	Homo sapiens	28-32
30804330-2	2019	We previously reported that GLDC downregulation enhances hepatocellular carcinoma (HCC) progression and intrahepatic metastasis through decreasing ROS-mediated ubiquitination of cofilin.	ros	147-150	cofilin 1	Homo sapiens	178-185
30359759-6	2019	Results show that hyperglycemia altered the expression of genes encoding the ROS-producing enzyme Nox4, antioxidant enzymes Cu/ZnSOD, catalase and HO-1 as well as Cu/ZnSOD, MnSOD and catalase enzymatic activities, leading to a time-dependent modulation of ROS levels.	ros	77-80	NADPH oxidase 4	Mus musculus	98-102
31133134-8	2019	CONCLUSION: Increasing ALDH2 expression in alveolar epithelial A549 cells may attenuate high glucose-induced cellular inflammatory reaction, possibly through reducing cellular ROS level and reducing inflammasome expression.	ros	176-179	aldehyde dehydrogenase 2 family member	Homo sapiens	23-28
30359759-6	2019	Results show that hyperglycemia altered the expression of genes encoding the ROS-producing enzyme Nox4, antioxidant enzymes Cu/ZnSOD, catalase and HO-1 as well as Cu/ZnSOD, MnSOD and catalase enzymatic activities, leading to a time-dependent modulation of ROS levels.	ros	256-259	NADPH oxidase 4	Mus musculus	98-102
30391825-4	2019	Mitochondrial efficiency was significantly reduced by Bhlhe40 knockdown, resulting in the burst of ROS.	ros	99-102	basic helix-loop-helix family member e40	Homo sapiens	54-61
30391825-5	2019	Over-expression of a constitutively active PGC-1alpha-interactive domain (named as VBH135) of Bhlhe40 mimicked the effects of its knockdown on peroxisomes but simultaneously reduced ROS level.	ros	182-185	basic helix-loop-helix family member e40	Homo sapiens	94-101
30933478-0	2019	ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer.	ros	0-3	microRNA 34a	Homo sapiens	88-95
30689938-9	2019	AMOT1/EIN3 positively regulates shoot ROS accumulation, leading to oxidative stress under NH4+ stress, a trait that may be related to increased expression of peroxidase-encoding genes.	ros	38-41	Ethylene insensitive 3 family protein	Arabidopsis thaliana	6-10
30736789-14	2019	CONCLUSIONS: These results indicate that STL or STB may induce GSK3beta-dependent cyclin D1 degradation, and increase HO-1 expression through activating Nrf2 via ROS-dependent p38 activation, which resulted in the decrease of the viability in SW480 cells.	ros	162-165	RNF217 antisense RNA 1 (head to head)	Homo sapiens	41-44
30538212-7	2018	Finally, we showed that silencing of NDUFA4L2 affects cell viability, increases mitochondrial mass, and induces ROS generation in hypoxia.	ros	112-115	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	37-45
31178965-10	2019	Based on these data, we conclude that LPS impairs StAR expression via the ROS-induced downregulation of GATA4 and GATA6.	ros	74-77	steroidogenic acute regulatory protein	Homo sapiens	50-54
30538220-5	2018	Glucose starvation induced progressive autophagy activation in PDA cells via the activation of ROS/AMPK signaling.	ros	95-98	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	99-103
30472366-8	2019	In a mechanistic study, addition of MT1 or RORalpha antagonist increased ROS and MDA concentrations, but decreased T-AOC, GPx, CAT and T-SOD concentrations (P &lt; 0.05), whereas there were no significant difference between the melatonin and MT2 antagonist treatment groups for T-AOC, GPx, CAT and T-SOD concentrations.	ros	73-76	nuclear receptor ROR-alpha	Ovis aries	43-51
30324853-7	2019	ROS decrease correlated also with the reduction of mitochondria, the main source of intracellular ROS, achieved by the downregulation of NRF1 and TFAM, mitochondrial biogenesis transcription factors.	ros	0-3	nuclear respiratory factor 1	Homo sapiens	137-141
30557609-5	2019	Mechanistically, DHA induced autophagy by regulating the activity of AMPK/mTOR/p70S6k signaling pathway, which accelerated the degradation of ferritin, increased the labile iron pool, promoted the accumulation of cellular ROS and eventually led to ferroptotic cell death.	ros	222-225	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	69-73
30324853-7	2019	ROS decrease correlated also with the reduction of mitochondria, the main source of intracellular ROS, achieved by the downregulation of NRF1 and TFAM, mitochondrial biogenesis transcription factors.	ros	98-101	nuclear respiratory factor 1	Homo sapiens	137-141
30480549-5	2019	Vasoconstriction blockade with the endothelin-1 inhibitor BQ-123, or ROS scavenging after SDRT using peroxiredoxin-6 overexpression or the SOD mimetic tempol, prevented chromatin SUMO3 depletion, HDR loss of function, and SDRT tumor ablation.	ros	69-72	peroxiredoxin 6	Homo sapiens	101-116
30707921-1	2019	BACKGROUND: The NADPH oxidase (NOX) 4 is an important source of ROS in signal transduction that acts as a liver tumor suppressor.	ros	64-67	NADPH oxidase 4	Homo sapiens	16-37
30554313-6	2019	Thus, it is possible to suggest that C-PC modulates the expression of COX2 and ABCB1 for the K562-Lucena in a ROS-dependent manner and the expression of ALOX5 for the FEPS in a ROS-independent manner; however, more studies are needed to elucidate these mechanisms.	ros	177-180	transient receptor potential cation channel subfamily A member 1	Homo sapiens	167-171
30700698-6	2019	Moreover, ROS scavengers demonstrated that the observed effect of cyclinB1 silencing on AMPK phosphorylation was ROS dependent.	ros	10-13	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	88-92
30700698-6	2019	Moreover, ROS scavengers demonstrated that the observed effect of cyclinB1 silencing on AMPK phosphorylation was ROS dependent.	ros	113-116	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	88-92
30696468-10	2019	Overexpression of AK4 exaggerates HIF-1alpha protein expression by increasing intracellular ROS levels and subsequently induces EMT under hypoxia.	ros	92-95	adenylate kinase 4	Homo sapiens	18-21
30513370-0	2019	Oleate increase neutral lipid accumulation, cellular respiration and rescues palmitate-exposed GLP-1 secreting cells by reducing ceramide-induced ROS.	ros	146-149	glucagon like peptide 1 receptor	Homo sapiens	95-100
30696468-11	2019	Attenuation of ROS production with N-acetylcysteine abolishes AK4-induced invasion potential under hypoxia.	ros	15-18	adenylate kinase 4	Homo sapiens	62-65
30805082-1	2019	Our preliminary data showed that VEGFR2 upregulation promoted renal ROS overproduction in high-fat diet- (HFD-) treated mice.	ros	68-71	kinase insert domain protein receptor	Mus musculus	33-39
30805082-2	2019	Given that ROS-induced NLRP3 activation plays a central role in the pathogenesis of type 2 diabetic kidney injury, we evaluate whether VEGFR2 upregulation induces type 2 diabetic kidney injury via ROS-mediated NLRP3 activation and further explore the underlying mechanism.	ros	197-200	kinase insert domain protein receptor	Mus musculus	135-141
30513370-8	2019	RESULTS: Generation of intracellular ceramide mediate a detrimental increased in ROS production following long term exposure to SFAs in GLP-1-secreting cells.	ros	81-84	glucagon like peptide 1 receptor	Homo sapiens	136-141
30805082-3	2019	Our results showed that VEGFR2 knockdown decreased ROS overproduction, blocked NLRP3-dependent inflammation, and alleviated kidney damage in HFD-treated mice.	ros	51-54	kinase insert domain protein receptor	Mus musculus	24-30
30805082-5	2019	Collectively, the VEGFR2/ROS/NLRP3 signal is a critical therapeutic strategy for the kidney injury of HFD-treated mice.	ros	25-28	kinase insert domain protein receptor	Mus musculus	18-24
30703374-4	2019	Mechanistically, angiotensin II induced robust ROS generation, which in turn triggered activation of pro-fibrotic TGFbeta1-Smad2/3 signaling and subsequent collagen synthesis and fibroblast-myofibroblast transformation in cardiac fibroblasts.	ros	47-50	transforming growth factor, beta 1	Mus musculus	114-122
30703377-2	2019	We have previously detected that TGHQ induces ROS-dependent necrotic or apoptotic cell death in renal epithelial HK-2 and human leukemic HL-60 cells respectively.	ros	46-49	hexokinase 2	Homo sapiens	113-117
30800207-9	2019	Increased ROS production occurred due to NOX4 upregulation by GI-761.	ros	10-13	NADPH oxidase 4	Homo sapiens	41-45
30703377-3	2019	Herein, we sought to determine the nature of the Nrf2 regulation in HK-2 and HL-60 cells undergoing TGHQ-mediated ROS-dependent cell death, due to the key role of Nrf2 in oxidative stress.	ros	114-117	hexokinase 2	Homo sapiens	68-72
30734183-5	2019	Our further results showed that high-dose PQ"s effects on cell proliferation, apoptosis, ROS levels and autophagy are reversed by p65 overexpression.	ros	89-92	RELA proto-oncogene, NF-kB subunit	Homo sapiens	130-133
30719278-7	2019	Moreover, knockdown of dUCH led to elevated level of ROS.	ros	53-56	Ubiquitin carboxy-terminal hydrolase	Drosophila melanogaster	23-27
31776986-4	2019	This section will focus on ROS-mediated regulation of autophagy through PI3K/Akt, AMPK, JNK, ERK, ATG4, and other pathways.	ros	27-30	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	82-86
30834779-9	2019	Inhibition of p38 activation and ROS elimination attenuated HO-1 expression by ST-L and ST-B, and ROS elimination inhibited p38 activation induced by ST-L and ST-B.	ros	98-101	mitogen-activated protein kinase 14	Mus musculus	124-127
30914692-9	2019	The production of intracellular ROS was significantly reduced in the presence of angiotensin II type1-receptor (AT1R) antagonist, whereas it was augmented in the presence of angiotensin II type2-receptor antagonist.	ros	32-35	angiotensin II receptor type 1	Homo sapiens	112-116
30914692-9	2019	The production of intracellular ROS was significantly reduced in the presence of angiotensin II type1-receptor (AT1R) antagonist, whereas it was augmented in the presence of angiotensin II type2-receptor antagonist.	ros	32-35	angiotensin II receptor type 2	Homo sapiens	174-203
30914692-10	2019	In conclusion, Ang II-induced oxidative stress was augmented by high glucose levels and ROS levels were further alleviated in the presence of AT1R antagonists.	ros	88-91	angiotensin II receptor type 1	Homo sapiens	142-146
30625496-4	2019	In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mphi function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to Pseudomonas aeruginosa (PA) infection and/or lipopolysaccharide (LPS) treatment.	ros	186-189	microRNA 183	Mus musculus	55-62
30949411-9	2019	Moreover, chidamide decreased the production of reaction oxygen species (ROS) via SDHA.	ros	73-76	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	82-86
30625496-4	2019	In this report, we provide evidence that the conserved miR-183/96/182 cluster (miR-183/96/182) modulates Mphi function in their production of reactive nitrogen (RNS) and oxygen species (ROS) and their inflammatory response to Pseudomonas aeruginosa (PA) infection and/or lipopolysaccharide (LPS) treatment.	ros	186-189	microRNA 183	Mus musculus	79-86
30625496-7	2019	In addition, overexpression of miR-183/96/182 results in decreased production of nitrite and ROS in Raw264.7 cells.	ros	93-96	microRNA 183	Mus musculus	31-38
30589411-3	2018	We identify the ROS-generating NADPH oxidase-4 (Nox4) as an essential regulator of exercise performance in mice.	ros	16-19	NADPH oxidase 4	Mus musculus	31-46
30579160-8	2019	In response to ROS generated by tobacco smoke increase the activity of antioxidant enzymes (SOD, GST, GPx and CAT), p &lt; 0.05.	ros	15-18	glutathione S-transferase	Nicotiana tabacum	97-100
30589411-3	2018	We identify the ROS-generating NADPH oxidase-4 (Nox4) as an essential regulator of exercise performance in mice.	ros	16-19	NADPH oxidase 4	Mus musculus	48-52
30586869-0	2018	Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1.	ros	96-99	heat shock transcription factor 1	Homo sapiens	123-127
30665058-11	2019	Our investigation indicated that the TaZFP1-mediated salt tolerance is ascribed to the regulation of gene functions related to photosynthesis, osmolytes metabolism and ROS homeostasis mediated by ABA signaling.	ros	168-171	E3 ubiquitin-protein ligase BRE1A	Triticum aestivum	37-43
30662585-12	2018	VEGFR2 oxidation occurred in response to PTH, suggesting that even the impairment of angiogenesis was due to the ROS surge.	ros	113-116	kinase insert domain receptor	Bos taurus	0-6
30531981-9	2018	Downregulation of NDUFA11 or SDHC reduced ATP production and increased mitochondrial ROS production.	ros	85-88	NADH:ubiquinone oxidoreductase subunit A11	Homo sapiens	18-25
30176346-9	2018	Axin-2 shRNA treatment reduced apoptotic signaling, autophagy and ROS generation and improved mitochondrial membrane potential which promotes mitochondrial biogenesis in SNpc in parkinsonian rats.	ros	66-69	axin 2	Rattus norvegicus	0-6
30136446-3	2018	Moreover, Ginkgolide B suppressed the enhanced NOX4 expression, which was associated with attenuation of ROS generation in ox-LDL-stimulated HUVECs and RAW264.7 cells.	ros	105-108	NADPH oxidase 4	Mus musculus	47-51
30482886-7	2018	Mechanistically, we demonstrated that TGF-beta could induce mitochondrial ROS (mtROS) production and mtROS scavenger could rescue CE cell senescence upon TGF-beta treatment.	ros	74-77	transforming growth factor alpha	Homo sapiens	38-46
30343565-0	2018	Glutamine Deficiency Promotes PCV2 Infection through Induction of Autophagy via Activation of ROS-Mediated JAK2/STAT3 Signaling Pathway.	ros	94-97	Janus kinase 2	Homo sapiens	107-111
30343565-7	2018	Inhibition of ROS generation alleviated the Gln deficiency-activated JAK2/STAT3 signaling pathway, thereby inhibiting autophagy induction.	ros	14-17	Janus kinase 2	Homo sapiens	69-73
30122554-5	2018	Decreased ROS production in KO-AOX versus KO mice led to impaired AMPK/PGC-1alpha signaling and PAX7/MYOD-dependent muscle regeneration, blunting compensatory responses.	ros	10-13	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	71-81
30397232-8	2018	We conclude that aberrant DNA methylation of Tgfb1 due to ROS overproduction play a key to mesangial fibrosis during DN progression.	ros	58-61	transforming growth factor, beta 1	Mus musculus	45-50
29800228-12	2018	Other studies revealed activation of ROS-ATM-LKB1-AMPK axis as a possible mechanism of PCSK-induced autophagy.	ros	37-40	ataxia telangiectasia mutated	Mus musculus	41-44
30213730-5	2018	In addition, ATO-treated U937 cells showed ROS-mediated inhibition of TET2 transcription, leading to downregulation of FOXP3 expression and in turn, suppression of FOXP3-mediated activation of Lyn and Akt.	ros	43-46	tet methylcytosine dioxygenase 2	Homo sapiens	70-74
30213730-5	2018	In addition, ATO-treated U937 cells showed ROS-mediated inhibition of TET2 transcription, leading to downregulation of FOXP3 expression and in turn, suppression of FOXP3-mediated activation of Lyn and Akt.	ros	43-46	forkhead box P3	Homo sapiens	119-124
30250025-5	2018	At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway.	ros	81-84	sirtuin 6	Homo sapiens	24-29
30250025-5	2018	At the molecular level, SIRT6-mediated autophagy was triggered by an increase of ROS levels, which, in turn, resulted in the activation of the AMPK-ULK1-mTOR signaling pathway.	ros	81-84	unc-51 like autophagy activating kinase 1	Homo sapiens	148-152
30181240-2	2018	We demonstrated that the necroptotic cell death effector mixed lineage kinase domain-like (MLKL) translocated from the cytoplasm to the plasma membrane and stimulated downstream NADPH oxidase-independent ROS production, loss of cytoplasmic granules, breakdown of the nuclear membrane, chromatin decondensation, histone hypercitrullination, and extrusion of bacteriostatic NETs.	ros	204-207	mixed lineage kinase domain like pseudokinase	Homo sapiens	57-89
30181240-2	2018	We demonstrated that the necroptotic cell death effector mixed lineage kinase domain-like (MLKL) translocated from the cytoplasm to the plasma membrane and stimulated downstream NADPH oxidase-independent ROS production, loss of cytoplasmic granules, breakdown of the nuclear membrane, chromatin decondensation, histone hypercitrullination, and extrusion of bacteriostatic NETs.	ros	204-207	mixed lineage kinase domain like pseudokinase	Homo sapiens	91-95
29935035-4	2018	Our results showed that Gm5091 negatively regulated cell migration, ROS content, IL-1beta secretion, and expression of Collagen I and markers of HSC activation including alpha-SMA and Desmin.	ros	68-71	predicted gene 5091	Mus musculus	24-30
29879311-6	2018	Additionally, in vitro incubation of neutrophils with ACPAhigh SF resulted in an increased ROS production and extracellular DNA release compared to neutrophils incubated with ACPA-negative SF.	ros	91-94	proteinase 3	Homo sapiens	54-58
30154812-6	2018	Under these conditions, RSL2 expression (but not RSL4) is activated linked to ROS production and root hair growth.	ros	78-81	ROOT HAIR DEFECTIVE 6-LIKE 2	Arabidopsis thaliana	24-28
30154812-8	2018	This study identifies a new layer of complexity between auxin, Pi nutrient availability and RSL2/RSL4 transcription factors all acting on ROS homeostasis and growth at the root hair level.	ros	138-141	ROOT HAIR DEFECTIVE 6-LIKE 2	Arabidopsis thaliana	92-96
29772252-6	2018	Meanwhile, overexpressing SRXN1 decreased the ROS generation and mitochondrial membrane potential, concomitant with the up-regulated primary antioxidant systems, such as PRDX1, PRDX3, TXNRD1, Catalase and SOD2.	ros	46-49	sulfiredoxin 1	Homo sapiens	26-31
30123351-5	2018	Moreover, phosphor mutants of CAP1 at the S307/S309 regulatory site had compromised rescue effects for both the invasiveness and the proliferation in CAP1-knockdown cells and GSK3beta kinase inhibitor LiCl inhibited cell phosphorylation site S307/S309 by up-regulating the expression of p53, BAK, BAD and cleaved PARP induced ROS production, decreased lung cancer cell viability, adhesion, proliferation, migration and invasion, and induction of apoptosis.	ros	326-329	cyclase associated actin cytoskeleton regulatory protein 1	Homo sapiens	30-34
30573951-16	2018	Furthermore, either higher dose of PION@E6 or higher power intensity of ultrasound initiated significantly better SDT effect and correspondingly higher level of intracellular ROS generation compared with lower dose of PION@E6 or ultrasound, respectively.	ros	175-178	gamma-secretase activating protein	Mus musculus	35-42
30573951-16	2018	Furthermore, either higher dose of PION@E6 or higher power intensity of ultrasound initiated significantly better SDT effect and correspondingly higher level of intracellular ROS generation compared with lower dose of PION@E6 or ultrasound, respectively.	ros	175-178	gamma-secretase activating protein	Mus musculus	218-225
30376625-12	2018	Correspondingly, inhibition of UGT1A9 and transporters led to increased kaempferol and, consequently, a significantly enhanced ROS scavenging efficiency and nuclear translocation of Nrf2.	ros	127-130	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	31-37
30244523-3	2018	Here, we demonstrate that TGF-beta1, a component of the SASP, causes telomere dysfunction in normal somatic human fibroblasts in a Smad3/NOX4/ROS-dependent manner.	ros	142-145	SMAD family member 3	Homo sapiens	131-136
30881027-10	2019	Mitochondrial uncoupling protein 2 (UCP2) protects against mitochondrial ROS while allowing energy metabolism to switch to glycolysis.	ros	73-76	uncoupling protein 2	Homo sapiens	0-34
30881027-10	2019	Mitochondrial uncoupling protein 2 (UCP2) protects against mitochondrial ROS while allowing energy metabolism to switch to glycolysis.	ros	73-76	uncoupling protein 2	Homo sapiens	36-40
30736789-13	2019	HO-1 expression by STL or STB resulted from Nrf2 activation through ROS-dependent p38 activation.	ros	68-71	RNF217 antisense RNA 1 (head to head)	Homo sapiens	19-22
30728013-12	2019	Anti-HMGB1 treatment reduced ODE-induced NF-kappaB p65 expression, IL-6, ROS and RNS but augmented TGF-beta1 and IL-10 levels.	ros	73-76	high mobility group box 1	Homo sapiens	5-10
30533174-2	2018	Nox2 is one of the predominant Nox enzymes expressed in the bone marrow microenvironment and is a major source of ROS generation during inflammatory processes.	ros	114-117	cytochrome b-245, beta polypeptide	Mus musculus	0-4
30237309-5	2018	TSC1 knockdown results in elevated mTORC1-dependent mitochondrial respiration enhanced ROS production and apoptosis.	ros	87-90	CREB regulated transcription coactivator 1	Mus musculus	35-41
30417303-0	2018	Combined Effect of TLR2 Ligands on ROS Production by Mouse Peritoneal Macrophages.	ros	35-38	toll-like receptor 2	Mus musculus	19-23
30417303-1	2018	TLR2-mediated ROS production by mouse peritoneal macrophages was studied by luminoldependent chemiluminescence under conditions of cell stimulation with zymosan (TLR2/6 ligand) and peptidoglycan (TLR2/1 ligand).	ros	14-17	toll-like receptor 2	Mus musculus	0-4
30417303-1	2018	TLR2-mediated ROS production by mouse peritoneal macrophages was studied by luminoldependent chemiluminescence under conditions of cell stimulation with zymosan (TLR2/6 ligand) and peptidoglycan (TLR2/1 ligand).	ros	14-17	toll-like receptor 2	Mus musculus	162-166
30417303-1	2018	TLR2-mediated ROS production by mouse peritoneal macrophages was studied by luminoldependent chemiluminescence under conditions of cell stimulation with zymosan (TLR2/6 ligand) and peptidoglycan (TLR2/1 ligand).	ros	14-17	toll-like receptor 2	Mus musculus	196-202
30145470-0	2018	4-Methylcatechol prevents streptozotocin-induced acute kidney injury through modulating NGF/TrkA and ROS-related Akt/GSK3beta/beta-catenin pathways.	ros	101-104	glycogen synthase kinase 3 beta	Homo sapiens	117-125
30096402-4	2018	It was shown that the lactoferrin nanoparticle repolarized the tumor-associated macrophages from the M2 phenotype to M1 via regulating the STAT6 pathway, as well as induced the ROS-mediated mitochondrial apoptosis by inhibiting the Ras/Raf/p-Erk pathway in the glioma cells.	ros	177-180	zinc fingers and homeoboxes 2	Homo sapiens	236-239
29559224-5	2018	Nox4, an ER resident capable of producing ROS, acts as a proximal signaling intermediate to transduce ER stress-related conditions to the unfolded protein response, a homeostatic corrective mechanism.	ros	42-45	NADPH oxidase 4	Homo sapiens	0-4
30342666-5	2018	Treatment of ROS with gonadotropin-releasing hormone analogs or high dose progestogens may be helpful.	ros	13-16	gonadotropin releasing hormone 1	Homo sapiens	22-52
30180843-9	2018	Remarkably, delivery of miR-21 efficiently protected against the early impairment in cardiac diastolic dysfunction, represented by decreased ROS production, increased bioavailable NO and relieved diabetes-induced cardiomyocyte hypertrophy in db/db mice.	ros	141-144	microRNA 21a	Mus musculus	24-30
30214444-0	2018	ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1beta Activation During Streptococcus pneumoniae Infection.	ros	56-59	activating transcription factor 3	Mus musculus	0-4
30214444-7	2018	Moreover, mitochondrial IL-1beta production by bone marrow-derived macrophages was significantly reduced in ATF3 KO mice as a result of the disruption of cellular ROS and Ca2+ homeostasis.	ros	163-166	activating transcription factor 3	Mus musculus	108-112
30135653-8	2018	Rapamycin also induced ROS generation and latent TGF-beta activation which contributed to TGF-beta-Smad signaling.	ros	23-26	SMAD family member 4	Homo sapiens	99-103
30044838-10	2018	The results show that the activation of mGluR2 and mGluR3 a short time after H-I triggers neuroprotective mechanisms that act through the inhibition of oxidative stress and ROS production.	ros	173-176	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	40-46
29565730-0	2018	Acetyl-macrocalin B, an ent-kaurane diterpenoid, initiates apoptosis through the ROS-p38-caspase 9-dependent pathway and induces G2/M phase arrest via the Chk1/2-Cdc25C-Cdc2/cyclin B axis in non-small cell lung cancer.	ros	81-84	mitogen-activated protein kinase 14	Mus musculus	85-88
29565730-10	2018	Both the ROS scavenger NAC and the specific p38 inhibitor SB203580 inactivated the function of p38 induced by A-macB, thus preventing cells from apoptosis.	ros	9-12	mitogen-activated protein kinase 14	Mus musculus	95-98
29663491-8	2018	Meanwhile, ROS levels, and malondialdehyde (MDA) were also restrained by miR-370 mimics in vitro.	ros	11-14	microRNA 370	Homo sapiens	73-80
29663491-12	2018	In conclusion, our present study revealed that miR-370 can reduce inflammatory reaction and inhibit the ROS production by targeting TLR4 in THP-1 cells.	ros	104-107	microRNA 370	Homo sapiens	47-54
29858119-8	2018	In addition, the ROS production and the activation of P13K/AKT/mTOR signaling induced by PDGF-BB were also suppressed by miR-27b overexpression or Nox2 silencing.	ros	17-20	microRNA 27b	Homo sapiens	121-128
29930336-8	2018	Furthermore, naringin counteracted fructose-induced cardiomyocyte apoptosis, and this function of naringin was linked to its ability to inhibit ROS-dependent ATM-mediated p53 signaling.	ros	144-147	ataxia telangiectasia mutated	Mus musculus	158-161
29983855-8	2018	In summary, our data suggest that PA endothelial dysfunction, induced by gp91phox-derived ROS, is an early event upon repetitive PE.	ros	90-93	cytochrome b-245, beta polypeptide	Mus musculus	73-81
29786653-9	2018	In parallel, knock down of CSE in differentiated rat cortical neuroblasts exaggerated the E-induced ROS, GSH loss with a pronounced caspase-3 activation and cell death.	ros	100-103	cystathionine gamma-lyase	Rattus norvegicus	27-30
29753331-1	2018	TIGAR is a p53 target gene that is known to protect cells from ROS-induced apoptosis by promoting the pentose phosphate pathway.	ros	63-66	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	0-5
29604305-8	2018	The current results suggest that the increase of ROS production by PVP-AgNPs stimulated SOD and CAT activity, as well as IRS-1, AKT, mTOR, p53, p21 and caspase 3 as protective mechanisms of cell survival and preserve DNA fidelity.	ros	49-52	caspase 3	Rattus norvegicus	152-161
29849862-3	2018	Recent studies have revealed that the renin-angiotensin system might play a role in kidney crystallization and ROS production.	ros	111-114	renin	Rattus norvegicus	38-43
29849862-9	2018	CaOx-induced ROS and stone-related protein upregulation were mediated by the Ang II/AT1R signaling pathway.	ros	13-16	angiotensin II receptor, type 1a	Rattus norvegicus	84-88
29666283-11	2018	We show that PI4P, a critical lipid for cardiovirus and enterovirus replication, is not strictly required for the formation of cardiovirus ROs, as functional ROs with typical morphologies are formed under phosphatidylinositol 4-kinase type III alpha (PI4KA) inhibition in cells infected with an escape mutant.	ros	158-161	phosphatidylinositol 4-kinase alpha	Homo sapiens	205-249
29849916-12	2018	The present study suggested that gefitinib could alleviate lung fibrosis through the HMGB1/NOXs-ROS/EGFR-MAPKs-AP-1/NF-kappaB signal in bleomycin-induced pulmonary fibrosis.	ros	96-99	high mobility group box 1	Mus musculus	85-90
29417167-6	2018	The cardiac-specific transcription factor Csx/Nkx2.5 played an important role in the induction of cardiac hypertrophy and cardiomyocyte injury, and the action was associated with ROS-HIF-1alpha transcriptional regulation and DNA hypomethylation modification.	ros	179-182	NK2 homeobox 5	Mus musculus	42-45
29417167-6	2018	The cardiac-specific transcription factor Csx/Nkx2.5 played an important role in the induction of cardiac hypertrophy and cardiomyocyte injury, and the action was associated with ROS-HIF-1alpha transcriptional regulation and DNA hypomethylation modification.	ros	179-182	NK2 homeobox 5	Mus musculus	46-52
29477034-0	2018	Alpinumisoflavone rescues glucocorticoid-induced apoptosis of osteocytes via suppressing Nox2-dependent ROS generation.	ros	104-107	cytochrome b-245, beta polypeptide	Mus musculus	89-93
29477034-10	2018	Furthermore, our data indicated that the expression of NAD(P)H oxidase 2 (Nox2) was suppressed by AIF, which in turn mediated the attenuating effect on Dex-induced ROS generation and apoptosis in MLO-Y4 cells.	ros	164-167	cytochrome b-245, beta polypeptide	Mus musculus	55-72
29477034-10	2018	Furthermore, our data indicated that the expression of NAD(P)H oxidase 2 (Nox2) was suppressed by AIF, which in turn mediated the attenuating effect on Dex-induced ROS generation and apoptosis in MLO-Y4 cells.	ros	164-167	cytochrome b-245, beta polypeptide	Mus musculus	74-78
29477034-12	2018	CONCLUSION: AIF activated AMPK-dependent Nox2 signaling pathway to suppress Dex-induced ROS production in cultured osteocytes, which might explain its anti-apoptotic effect.	ros	88-91	cytochrome b-245, beta polypeptide	Mus musculus	41-45
28942194-6	2018	OGC but not DIC downregulation by siRNA depleted mGSH levels and sensitized HCC cells to hypoxia-induced ROS generation and cell death as well as impaired cell growth in three-dimensional multicellular HCC spheroids, effects that were reversible upon mGSH replenishment by GSH ethyl ester, a membrane permeable GSH precursor.	ros	105-108	solute carrier family 25 member 11	Homo sapiens	0-3
29367253-6	2018	We also found various previously unknown interactions among the AiV proteins (2B, 2BC, 2C, 3A, and 3AB), ACBD3, OSBP, VAP-A/B, and SAC1, and the interactions were suggested to be involved in recruiting the component proteins to AiV ROs.	ros	232-235	SAC1 like phosphatidylinositide phosphatase	Homo sapiens	131-135
29765497-6	2018	Yet the excess generation of ROS induced by DpdtbA led to cathepsin D translocation and increase of autophagic vacuoles and LC3-II, demonstrating that autophagy was also a contributor to growth inhibition.	ros	29-32	cathepsin D	Homo sapiens	58-69
29165856-6	2018	We found that the sod1  mutant was hypersensitive to honokiol and produced more ROS compared with wild-type and sod2  cells.	ros	80-83	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	18-22
29362078-6	2018	Arabidopsis pete1 and pete2 mutants showed ROS-sensitive phenotypes that could be restored by expression of SsPETE2 or AtPETEs.	ros	43-46	Cupredoxin superfamily protein	Arabidopsis thaliana	22-27
29229420-0	2018	ROS-mediated oligomerization of VDAC2 is associated with quinocetone-induced apoptotic cell death.	ros	0-3	voltage dependent anion channel 2	Homo sapiens	32-37
29229420-7	2018	In addition, caspase inhibitor Z-VAD-FMK and reactive oxidative species (ROS) scavenger N-acetyl-l-cysteine (NAC) apparently blocked QCT-induced cell death and VDAC2 oligomerization.	ros	73-76	voltage dependent anion channel 2	Homo sapiens	160-165
29229420-9	2018	Taken together, our results reveal that ROS-mediated VDAC2 oligomerization is associated with QCT-induced apoptotic cell death.	ros	40-43	voltage dependent anion channel 2	Homo sapiens	53-58
30022064-5	2018	Tbkbp1 deficiency attenuates IL-15-stimulated NKT cell autophagy, and is associated with mitochondrial dysfunction, aberrant ROS production, defective Bcl2 expression and reduced NKT cell survival.	ros	125-128	TBK1 binding protein 1	Mus musculus	0-6
29753724-6	2018	Knockdown of ID2 promoted cell apoptosis and increased ROS level in RPE cells that were subjected to oxidative damage.	ros	55-58	inhibitor of DNA binding 2	Mus musculus	13-16
30022966-11	2018	Based on a linear regression analysis, GSTM2 and UGT2A1 were found to be the most influential genes in ROS detoxification.	ros	103-106	glutathione S-transferase, mu 2	Mus musculus	39-44
29804242-8	2018	The Cdc42 inhibitor CASIN increased adipogenic and osteogenic differentiation potential in ADMSCs from 24-month old rats, and decreased the levels of radical oxygen species (ROS), p16INK4a levels, F-actin, and the activity of the ERK1/2 and JNK signaling pathways that were all elevated in these cells.	ros	174-177	cell division cycle 42	Rattus norvegicus	4-9
29864924-9	2018	We also found that p38 and ERK inhibitors significantly antagonized the increase in cell viability and cellular ROS scavenging activity induced by NNLE.	ros	112-115	mitogen-activated protein kinase 14	Mus musculus	19-22
29857913-10	2018	AMPK, an evolutionarily conserved kinase activated by increases in intracellular Ca2+, ROS, and/or AMP/ATP ratio increases improves lifespan and healthspan in several model organisms and is essential for T cell activation.	ros	87-90	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-4
29857913-14	2018	Because both T cell activation and LTP are dependent on intracellular Ca2+ increases and because inhibition of ROS significantly inhibits hippocampal CA1 LTP and T cell activation, it is our hypothesis that AMPK links latent HIV-1 reactivation with hippocampal LTP, learning, and memory.	ros	111-114	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	207-211
29733381-7	2018	Our functional studies highlighted the importance of the HSF1-FOXO3-SOD2/CAT/GADD45A cascade in cellular stress response and survival by promoting ROS detoxification, redox balance and DNA repair.	ros	147-150	heat shock transcription factor 1	Homo sapiens	57-61
29733381-7	2018	Our functional studies highlighted the importance of the HSF1-FOXO3-SOD2/CAT/GADD45A cascade in cellular stress response and survival by promoting ROS detoxification, redox balance and DNA repair.	ros	147-150	superoxide dismutase 2	Homo sapiens	68-72
29733381-7	2018	Our functional studies highlighted the importance of the HSF1-FOXO3-SOD2/CAT/GADD45A cascade in cellular stress response and survival by promoting ROS detoxification, redox balance and DNA repair.	ros	147-150	growth arrest and DNA damage inducible alpha	Homo sapiens	77-84
29967662-5	2018	We found that NIX-mediated mitophagy was impaired in bone marrow nucleated red blood cells (NRBC) of MDS patients, associated with an increased amount of damaged mitochondria and increased ROS level which might lead to apoptosis and ineffective erythropoiesis.	ros	189-192	BCL2 interacting protein 3 like	Homo sapiens	14-17
29637793-4	2018	SIRT5 regulates protein substrates involved in glycolysis, the TCA cycle, fatty acid oxidation, electron transport chain, ketone body formation, nitrogenous waste management, and ROS detoxification, among other processes.	ros	179-182	sirtuin 5	Homo sapiens	0-5
29410271-8	2018	In addition, a ROS scavenger N-acetyl-l-cysteine (NAC) down-regulated the protein level of p-p38, p-JNK and Prdx1, and H9c2 cell apoptosis.	ros	15-18	mitogen activated protein kinase 14	Rattus norvegicus	93-96
29137940-1	2018	Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase.	ros	136-139	NADPH oxidase 1	Homo sapiens	20-35
29137940-1	2018	Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase.	ros	136-139	NADPH oxidase 1	Homo sapiens	37-41
29137940-1	2018	Tumor cells express NADPH oxidase-1 (NOX1) in their membrane and control NOX1-based intercellular reactive oxygen and nitrogen species (ROS/RNS)-dependent apoptosis-inducing signaling through membrane-associated catalase and superoxide dismutase.	ros	136-139	NADPH oxidase 1	Homo sapiens	73-77
29428221-5	2018	The inflammatory response in the stroma induces TNF-alpha signaling in tumor cells, and the NOX1/ROS signaling pathway is activated downstream.	ros	97-100	NADPH oxidase 1	Mus musculus	92-96
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	oxidized low density lipoprotein receptor 1	Homo sapiens	71-76
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	oxidized low density lipoprotein receptor 1	Homo sapiens	71-76
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	oxidized low density lipoprotein receptor 1	Homo sapiens	71-76
29211299-11	2018	Above all, LOX-1+  CD15+ PMN-MDSC were elevated in HCC patients and suppressed T cell proliferation through ROS/Arg I pathway induced by ER stress.	ros	108-111	oxidized low density lipoprotein receptor 1	Homo sapiens	11-16
29568385-3	2018	There is a growing body of evidence suggesting that a pro-inflammatory microenvironment (e.g. ROS and cytokines) promotes CAF formation during tumorigenesis, although the exact mechanisms involved remain unclear.	ros	94-97	lysine acetyltransferase 2B	Homo sapiens	122-125
29330265-1	2018	PIN4 is a FGFR3-TACC3 substrate required for ROS-mediated induction of PGCIalpha and tumor growth.	ros	45-48	peptidylprolyl cis/trans isomerase, NIMA-interacting 4	Homo sapiens	0-4
29129468-4	2018	Furthermore, the levels of p-PI3K, p-Akt and p-mTOR increased, while 8-OHdG, ROS production and Bcl-2/Rac1 complex formation in mitochondria reduced in both Rac1-shRNA- and NSC23766-treated rats.	ros	77-80	Rac family small GTPase 1	Rattus norvegicus	157-161
29552311-7	2018	Overexpression of miR-29b in oxaliplatin-treated OR-SW480 decreased the expression of SIRT1 to enhance the ROS production and JNK phosphorylation, and thus promoting apoptosis via activation of caspase 9, 7 and 3.	ros	107-110	microRNA 29b-1	Homo sapiens	18-25
29307831-9	2018	Taken together, these data demonstrate that ATO induces osteosarcoma cell death via inducing excessive autophagy, which is mediated through the ROS-TFEB pathway.	ros	144-147	transcription factor EB	Homo sapiens	148-152
28918503-0	2018	CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice.	ros	62-65	protein tyrosine phosphatase receptor type U	Homo sapiens	27-30
28918503-0	2018	CoQ0-induced mitochondrial PTP opening triggers apoptosis via ROS-mediated VDAC1 upregulation in HL-60 leukemia cells and suppresses tumor growth in athymic nude mice/xenografted nude mice.	ros	62-65	voltage dependent anion channel 1	Homo sapiens	75-80
28918503-11	2018	Intriguingly, VDAC1 silencing did not prevent ROS production induced by CoQ0, which in turn indicates that CoQ0 induced ROS-mediated VDAC1 and then mitochondrial apoptosis in HL-60 cells.	ros	120-123	voltage dependent anion channel 1	Homo sapiens	133-138
28986220-0	2018	Two mutations in mitochondrial ATP6 gene of ATP synthase, related to human cancer, affect ROS, calcium homeostasis and mitochondrial permeability transition in yeast.	ros	90-93	mitochondrially encoded ATP synthase 6	Homo sapiens	31-35
30257244-9	2018	Effective knockdown of FAK in HU-ESTs elevated cell viability and NO levels while suppressing ROS levels.	ros	94-97	protein tyrosine kinase 2	Homo sapiens	23-26
29462796-6	2018	Triclosan stimulated ROS production and oxidative stress occurrence, thereby activating the p38 pathway in vivo and in vitro.	ros	21-24	mitogen activated protein kinase 14	Rattus norvegicus	92-95
29768267-0	2018	Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3sigma.	ros	63-66	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	91-112
29768267-12	2018	Results from further analyses showed that AKT-ROS-dependent upregulations of expression, binding and centrosome translocation of ROCK1 and 14-3-3sigma was the molecular pathway underlying the centrosome amplification in vitro triggered by high glucose, insulin and palmitic acid.	ros	46-49	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	129-150
29768267-14	2018	CONCLUSION: Our results show that type 2 diabetes promotes cell centrosome amplification, and suggest that the diabetic pathophysiological factors-activated AKT-ROS-dependent signalling of ROCK1 and 14-3-3sigma is the underlying molecular mechanism.	ros	161-164	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	189-210
30393577-14	2018	Conclusion: Our findings provide evidence that decreased mitochondrial protein expression of COXIV-1 and ATPase6 correlates with increased ROS production during colorectal adenomatous polyps" progression, suggesting the pivotal role of COXIV-1 in energy metabolism of colorectal cells as they progress from polyps to carcinoma.	ros	139-142	cytochrome c oxidase subunit 4I1	Homo sapiens	93-100
30393577-14	2018	Conclusion: Our findings provide evidence that decreased mitochondrial protein expression of COXIV-1 and ATPase6 correlates with increased ROS production during colorectal adenomatous polyps" progression, suggesting the pivotal role of COXIV-1 in energy metabolism of colorectal cells as they progress from polyps to carcinoma.	ros	139-142	mitochondrially encoded ATP synthase 6	Homo sapiens	105-112
30393577-14	2018	Conclusion: Our findings provide evidence that decreased mitochondrial protein expression of COXIV-1 and ATPase6 correlates with increased ROS production during colorectal adenomatous polyps" progression, suggesting the pivotal role of COXIV-1 in energy metabolism of colorectal cells as they progress from polyps to carcinoma.	ros	139-142	cytochrome c oxidase subunit 4I1	Homo sapiens	236-243
30504713-8	2018	RESULTS: Compared with the controls, MIOX expression was significantly increased in the renal tissues of T2DN patients, and was positively correlated with tubulointerstitial lesions and renal ROS production but inversely correlated with Sirt1 expression.	ros	192-195	myo-inositol oxygenase	Homo sapiens	37-41
28943238-0	2017	Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal beta-arrestin phosphosensor in Raw 264.7 macrophages.	ros	44-47	free fatty acid receptor 4	Homo sapiens	0-26
28943238-0	2017	Free-fatty acid receptor-4 (FFA4) modulates ROS generation and COX-2 expression via the C-terminal beta-arrestin phosphosensor in Raw 264.7 macrophages.	ros	44-47	free fatty acid receptor 4	Homo sapiens	28-32
28943238-5	2017	Our data reveal for the first time that both FFA4 isoforms modulate PMA-induced ROS generation, and that abolishment of the FFA4-S, but not FFA4-L C-terminal phosphosensor, is detrimental to this effect.	ros	80-83	free fatty acid receptor 4	Homo sapiens	45-49
28943238-9	2017	Taken together, our data reveal important structure-function and signaling differences between the two FFA4 isoforms, and for the first time link FFA4 to modulation of ROS in macrophages.	ros	168-171	free fatty acid receptor 4	Homo sapiens	146-150
28430389-8	2017	The ROS generated by the combination of carmustine and selenite exhibited a strong inhibition on EGF stimulated EGFR and its downstream signaling molecules such as Akt, NF-kB, ERK1/2, and Cyclin D1.	ros	4-7	cyclin D1	Homo sapiens	188-197
29074644-9	2017	These findings reveal renal ERK1/2 as an important initial regulator of KIM-1 expression in IR and septic AKI and at a physiologic level.Visual Abstract.Proposed mechanism of IR, LPS, and ROS-induced renal damage that initiates ERK1/2 and STAT3 phosphorylation.	ros	188-191	mitogen-activated protein kinase 3	Mus musculus	28-34
29074644-9	2017	These findings reveal renal ERK1/2 as an important initial regulator of KIM-1 expression in IR and septic AKI and at a physiologic level.Visual Abstract.Proposed mechanism of IR, LPS, and ROS-induced renal damage that initiates ERK1/2 and STAT3 phosphorylation.	ros	188-191	mitogen-activated protein kinase 3	Mus musculus	228-234
29312589-6	2017	G6PD up-regulated ROS generation by facilitating NADPH-dependent NOX4 activation, which led to increased expression of p-STAT3 and CyclinD1.	ros	18-21	NADPH oxidase 4	Homo sapiens	65-69
28774732-0	2017	Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells.	ros	108-111	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	18-23
28880721-10	2017	On the contrary, an enhanced ROS generation in mouse brain after irradiation was markedly attenuated in the presence of NOX inhibitors or NOX-2 neutralizing antibody.	ros	29-32	cytochrome b-245, beta polypeptide	Mus musculus	138-143
28444875-5	2017	In addition, pre-treatment with the ROS scavenger NAC prevented the MGO-induced down-regulation of p65 and c-FLIPL , and the forced expression of c-FLIPL attenuated MGO-mediated apoptosis.	ros	36-39	RELA proto-oncogene, NF-kB subunit	Homo sapiens	99-102
28867437-5	2017	Quinacrine-treated U937 cells showed ROS-mediated p38 MAPK activation and ERK inactivation, which in turn upregulated FOXP3 transcription.	ros	37-40	forkhead box P3	Homo sapiens	118-123
28812425-0	2017	Nasunin inhibits the lipopolysaccharide-induced pro-inflammatory mediator production in RAW264 mouse macrophages by suppressing ROS-mediated activation of PI3 K/Akt/NF-kappaB and p38 signaling pathways.	ros	128-131	mitogen-activated protein kinase 14	Mus musculus	179-182
28812425-6	2017	Moreover, nasunin inhibited the intracellular accumulation of ROS, leading to the suppression of NF-kappaB activation, Akt and p38 phosphorylation, and subsequent pro-inflammatory mediator production.	ros	62-65	mitogen-activated protein kinase 14	Mus musculus	127-130
28945799-11	2017	Moreover, the absence of A/N-InvH prevented ROS formation, not only in invh roots of salt- and ABA-treated seedlings but also in invh control roots.	ros	44-47	invertase H	Arabidopsis thaliana	29-33
28945799-11	2017	Moreover, the absence of A/N-InvH prevented ROS formation, not only in invh roots of salt- and ABA-treated seedlings but also in invh control roots.	ros	44-47	invertase H	Arabidopsis thaliana	71-75
28945799-11	2017	Moreover, the absence of A/N-InvH prevented ROS formation, not only in invh roots of salt- and ABA-treated seedlings but also in invh control roots.	ros	44-47	invertase H	Arabidopsis thaliana	129-133
28736227-8	2017	Thus, PTP-dependent swelling of mitochondria solely depends on Ca2+ but not ROS.	ros	76-79	protein tyrosine phosphatase, non-receptor type 13	Rattus norvegicus	6-9
28644965-0	2017	3, 4-dihydroxybenzalacetone attenuates lipopolysaccharide-induced inflammation in acute lung injury via down-regulation of MMP-2 and MMP-9 activities through suppressing ROS-mediated MAPK and PI3K/AKT signaling pathways.	ros	170-173	matrix metallopeptidase 9	Mus musculus	133-138
28713956-5	2017	Pretreatment with MDG-1 markedly reduced H2O2-induced cell death, ROS generation and inflammatory factor secretion.	ros	66-69	DnaJ heat shock protein family (Hsp40) member B9	Homo sapiens	18-23
28855729-2	2017	Now, a study highlights the importance of ZSCAN10-dependent recovery of glutathione-ROS homeostasis in counteracting the genomic defects in A-iPSCs.	ros	84-87	zinc finger and SCAN domain containing 10	Homo sapiens	42-49
28596380-10	2017	We propose that during inflammation, apo-hemopexin is nitrated and oxidated in niches of the body containing activated RNS- and ROS-generating immune and endothelial cells, potentially impairing hemopexin"s protective extracellular antioxidant function.	ros	128-131	hemopexin	Homo sapiens	41-50
29348836-7	2017	Consequently, HSF-1 hyperphosphorylation mediated by JNK operation causes transcriptional inactivation of HSF-1, and supported ROS-mediated autophagy induction.	ros	127-130	heat shock transcription factor 1	Homo sapiens	14-19
28641152-5	2017	Urea-induced ROS reduced the number of endothelial cell colony forming units, uptake and binding of Dil-Ac-LDL and lectin-1, and the ability to differentiate into CD31- and vascular endothelial growth factor receptor 2-positive cells.	ros	13-16	platelet and endothelial cell adhesion molecule 1	Homo sapiens	163-167
28437565-3	2017	METHODS: A ROS version of PAPA with HOTV penalty (ROS-HOTV-PAPA) for PET image reconstruction was developed and implemented.	ros	11-14	pappalysin 1	Homo sapiens	26-30
28437565-3	2017	METHODS: A ROS version of PAPA with HOTV penalty (ROS-HOTV-PAPA) for PET image reconstruction was developed and implemented.	ros	11-14	pappalysin 1	Homo sapiens	59-63
28437565-11	2017	RESULTS: ROS-HOTV-PAPA converged rapidly, in comparison to non-ROS-HOTV-PAPA, with no evidence of limit cycle behavior.	ros	9-12	pappalysin 1	Homo sapiens	18-22
28437565-14	2017	Images of the measured phantom reconstructed using ROS-HOTV-PAPA showed reductions in RMSE of 5%-44% as compared with optimized OSEM.	ros	51-54	pappalysin 1	Homo sapiens	60-64
28437565-16	2017	Further, ROS-HOTV-PAPA reconstructions produced images with RMSE similar to images reconstructed using optimally post-filtered OSEM but at one-quarter the NEC.	ros	9-12	pappalysin 1	Homo sapiens	18-22
28437565-17	2017	CONCLUSION: Acceleration of HOTV-PAPA was achieved using ROS.	ros	57-60	pappalysin 1	Homo sapiens	28-37
28781602-9	2017	CONCLUSION: Our findings suggest that eIF2alpha phosphorylation maintains NADPH and GSH levels and controls the expression of ROS-defense genes, thereby protecting hepatocytes from oxidative stresses induced by fructose metabolism.	ros	126-129	eukaryotic translation initiation factor 2A	Mus musculus	38-47
28292711-4	2017	Ang II significantly up-regulated MMP-9 expression and cell migration of HASMCs, which was inhibited by transfection with siRNA of p47phox, Nox2, Nox4, p65, angiotensin II type 1 receptor (AT1R) and pretreatment with the inhibitors of NADPH oxidase, ROS, and NF-kappaB.	ros	250-253	angiogenin	Homo sapiens	0-3
28292711-5	2017	In addition, Ang II also induced NADPH oxidase/ROS generation and p47phox translocation from the cytosol to the membrane.	ros	47-50	angiogenin	Homo sapiens	13-16
28702557-5	2017	1-Ga can induce A549 cell apoptosis via ROS-mediated mitochondrial pathways, in which p38 and sirt-1 proteins play a key role.	ros	40-43	mitogen-activated protein kinase 14	Mus musculus	86-89
28740091-4	2017	Importantly, we demonstrated that the expression of TRMU, GTPBP3 and MTO1 is regulated by different miRNAs, which are induced by retrograde signals like ROS and Ca2+ via different pathways.	ros	153-156	GTP binding protein 3, mitochondrial	Homo sapiens	58-64
28740091-4	2017	Importantly, we demonstrated that the expression of TRMU, GTPBP3 and MTO1 is regulated by different miRNAs, which are induced by retrograde signals like ROS and Ca2+ via different pathways.	ros	153-156	mitochondrial tRNA translation optimization 1	Homo sapiens	69-73
28495310-8	2017	Finally, we demonstrated that PM enhanced NF-kappaB p65 phosphorylation and the NF-kappaB promoter activity, which were reduced by pretreatment with a ROS inhibitor or resveratrol.	ros	151-154	RELA proto-oncogene, NF-kB subunit	Homo sapiens	52-55
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	43-46	regulator of G protein signaling 12	Homo sapiens	209-215
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 12	Homo sapiens	209-215
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 12	Homo sapiens	209-215
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 12	Homo sapiens	209-215
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	regulator of G protein signaling 12	Homo sapiens	209-215
28249219-8	2017	Kidney dysfunction was paralleled by upregulation of ROS generating enzymes such as NOX2, NOX4 and iNOS with concomitant oxidative stress.	ros	53-56	cytochrome b-245, beta polypeptide	Mus musculus	84-88
28249219-8	2017	Kidney dysfunction was paralleled by upregulation of ROS generating enzymes such as NOX2, NOX4 and iNOS with concomitant oxidative stress.	ros	53-56	NADPH oxidase 4	Mus musculus	90-94
28216620-12	2017	Our results suggest that an autophagy- and p38/ROS-dependent pathway mediates the anti-cardiac fibrosis effect of ASA in CFs.	ros	47-50	mitogen-activated protein kinase 14	Mus musculus	43-46
27912197-9	2017	The inhibition of Rac1 by NSC23766 inhibited NADPH oxidase activity and ROS generation induced by high glucose concentrations in INS-1 &amp; human 1.1b4 beta cells.	ros	72-75	Rac family small GTPase 1	Rattus norvegicus	18-22
28435452-3	2017	Mechanistically, increased KRAS expression induced ROS production, which elevated HIF-1alpha and YAP1 expression.	ros	51-54	Yes1 associated transcriptional regulator	Homo sapiens	97-101
28435452-4	2017	Increased HIF-1alpha persistently promoted DDX3 expression via a KRAS/ROS/HIF-1alpha feedback loop.	ros	70-73	DEAD-box helicase 3 X-linked	Homo sapiens	43-47
28176763-2	2017	Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-beta-p38MAPK balances HSPC self-renewal and differentiation.	ros	57-60	contactin associated protein 1	Homo sapiens	43-47
28011270-7	2017	Sodium hydrosulfide (an exogenous H2S donor) and Nox4 siRNA inhibited Ang II-induced ROS production and Ang II-induced expression of Kv1.5, P-Smad2/3, P-ERK 1/2.	ros	85-88	NADPH oxidase 4	Homo sapiens	49-53
28567457-13	2017	In summary, the data demonstrated that linalool exhibited inhibitory effect on glioma cells through regulation of SIRT3-SOD2-ROS signaling.	ros	125-128	superoxide dismutase 2	Homo sapiens	120-124
29238726-6	2017	Mechanistically, AGEs increased PFN-1 expression through elevating ROS production and RhoA and ROCK2 expression.	ros	67-70	profilin 1	Rattus norvegicus	32-37
28142150-6	2017	Upregulated ATF-3 expression was followed by a marked elevation in ROS levels.	ros	67-70	activating transcription factor 3	Mus musculus	12-17
29035891-0	2017	Inhibiting ROS-TFEB-Dependent Autophagy Enhances Salidroside-Induced Apoptosis in Human Chondrosarcoma Cells.	ros	11-14	transcription factor EB	Homo sapiens	15-19
29035891-9	2017	Furthermore, NAC, a ROS scavenger, abrogated the effects of salidroside on TFEB-dependent autophagy.	ros	20-23	transcription factor EB	Homo sapiens	75-79
29035891-10	2017	CONCLUSIONS: These data demonstrate that salidroside increased TFEB-dependent autophagy by activating ROS signaling pathways in human chondrosarcoma cells.	ros	102-105	transcription factor EB	Homo sapiens	63-67
29035891-11	2017	These data also suggest that blocking ROS-TFEB-dependent autophagy to enhance the activity of salidroside warrants further attention in treatment of human chondrosarcoma cells.	ros	38-41	transcription factor EB	Homo sapiens	42-46
28630659-6	2017	The inhibition of NOX4 decreased the production of ROS and alleviated the Hcy-induced HUVEC apoptosis and ER stress.	ros	51-54	NADPH oxidase 4	Homo sapiens	18-22
27463837-8	2017	Sesn2 ablation increased UVA-induced Nrf2 induction and inhibits UVA-induced ROS production, indicating that Sesn2 acts as an upstream regulator of Nrf2.	ros	77-80	sestrin 2	Homo sapiens	0-5
27993686-7	2017	Overexpression of miR-126 could decrease the expression of downstream components of HMGB1 including TNF-alpha, ROS, and NADPH oxidase activity in HUVECs under hyperglycemic condition.	ros	111-114	high mobility group box 1	Mus musculus	84-89
27993686-12	2017	In summary, our findings suggest that miR-126 may suppress inflammation and ROS production in endothelial cells treated by high glucose through modulating the expression of HMGB1.	ros	76-79	high mobility group box 1	Mus musculus	173-178
26961672-5	2016	ROS production has been shown to activate the inflammasome complex in MO leading to increased production of the pro-inflammatory cytokine Interleukin-1beta (IL-1beta).	ros	0-3	interleukin 1 beta	Bos taurus	138-155
26961672-5	2016	ROS production has been shown to activate the inflammasome complex in MO leading to increased production of the pro-inflammatory cytokine Interleukin-1beta (IL-1beta).	ros	0-3	interleukin 1 beta	Bos taurus	157-165
30726742-7	2019	beta2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1beta production, which promotes ILC3-derived IL-22.	ros	75-78	Rac family small GTPase 1	Mus musculus	70-74
27867356-6	2016	In addition, 1,3-DCP (2 mmol/L) exposure significantly increased the ROS level and mitochondrial membrane potential damage ratio, leading to a decrease in progesterone production, while C3G intervention reduced the ROS level, and increased the progesterone production after 24 h treatment.	ros	215-218	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	186-189
30543783-12	2019	In conclusion, our results demonstrate that MFA attenuated liver fibrosis and hepatic stellate cell activation by inhibiting the TGF-beta1/Smad and NOX4/ROS signalling pathways.	ros	153-156	NADPH oxidase 4	Homo sapiens	148-152
27276511-4	2016	RESULTS: Metformin and resveratrol inhibited ROS-associated mitochondrial fission by upregulating Drp1 phosphorylation (Ser 637) in an AMPK-dependent manner, and then suppressed ER stress indicated by dephosphorylation of IRE1alpha and eIF2alpha in the adipose tissue.	ros	45-48	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	222-231
27276511-4	2016	RESULTS: Metformin and resveratrol inhibited ROS-associated mitochondrial fission by upregulating Drp1 phosphorylation (Ser 637) in an AMPK-dependent manner, and then suppressed ER stress indicated by dephosphorylation of IRE1alpha and eIF2alpha in the adipose tissue.	ros	45-48	eukaryotic translation initiation factor 2A	Mus musculus	236-245
29512760-0	2018	Artesunate suppresses oxidative and inflammatory processes by activating Nrf2 and ROS-dependent p38 MAPK and protects against cerebral ischemia-reperfusion injury.	ros	82-85	mitogen-activated protein kinase 14	Mus musculus	96-104
29512760-9	2018	In conclusion, the present findings suggested that artesunate may exert protective effects against CIRI through the suppression of oxidative and inflammatory processes, via activating Nrf2 and downregulating ROS-dependent p38 MAPK in mice.	ros	208-211	mitogen-activated protein kinase 14	Mus musculus	222-225
30700698-5	2019	Here we pioneeringly elaborated that specific knockdown of cyclinB1 triggered autophagy via AMPK-ULK1-dependent signal pathway through the elevation of ROS, rather than ATP in the cell lines of CNE-1 and CNE-2.	ros	152-155	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	92-96
27586257-5	2016	HSF4 and alpha B-crystallin can selectively protect lens epithelial cells from cisplatin and H2O2 induced apoptosis by stabilizing mitochondrial membrane potential (DeltaYm) and reducing ROS production.	ros	187-190	crystallin, alpha B	Mus musculus	9-27
30700698-5	2019	Here we pioneeringly elaborated that specific knockdown of cyclinB1 triggered autophagy via AMPK-ULK1-dependent signal pathway through the elevation of ROS, rather than ATP in the cell lines of CNE-1 and CNE-2.	ros	152-155	unc-51 like autophagy activating kinase 1	Homo sapiens	97-101
30580996-0	2019	Transmembrane protein 126B protects against high fat diet (HFD)-induced renal injury by suppressing dyslipidemia via inhibition of ROS.	ros	131-134	transmembrane protein 126B	Mus musculus	0-26
27647162-6	2016	Activation of A2AR suppressed LPS-induced autophagy by inhibiting the ROS-JNK pathway as well as promoting GPCR betaUpsilon subunit-AKT signaling.	ros	70-73	adenosine A2a receptor	Mus musculus	14-18
27540389-8	2016	Virus-induced gene silencing-mediated silencing of SlTPS3, SlTPS4, or SlTPS7 led to deregulation of ROS accumulation and attenuated the expression of defense-related genes upon pathogen infection and thus deteriorated the resistance against B. cinerea or Pst DC3000.	ros	100-103	(E)-beta-ocimene synthase	Solanum lycopersicum	70-76
29849922-6	2018	AGE-induced Synd4 shedding was partly reversed by NAC or resveratrol, along with normalized ROS production.	ros	92-95	syndecan 4	Homo sapiens	12-17
30580996-11	2019	Importantly, inhibiting Nrf-2 expression abolished Tmem126b knockdown-alleviated lipid deposition, apoptosis, inflammation, ROS generation and mitochondrial dysfunction.	ros	124-127	transmembrane protein 126B	Mus musculus	51-59
30740361-3	2019	We found that, the anti-Lewis B mAb light-chain CDR1 synthetic peptide Rb44, interacted with microtubules and induced depolymerization, with subsequent degradation of actin filaments, leading to depolarization of mitochondrial membrane-potential, increase of ROS, cell cycle arrest at G2/M, cleavage of caspase-9, caspase-3 and PARP, upregulation of Bax and downregulation of Bcl-2, altogether resulting in intrinsic apoptosis of melanoma cells.	ros	259-262	cerebellar degeneration related antigen 1	Mus musculus	48-52
29475156-4	2018	6p also significantly induces both EC9706 and EC109 cell cycle arrest at G0/G1 phase and cell apoptosis, as well as intracellular ROS accumulation, which could be markedly reversed caspase or ROS inhibitor: NAC.	ros	130-133	caspase 8	Homo sapiens	181-188
27151304-0	2016	MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappaB and ROS formation upon ligand binding.	ros	130-133	S100 calcium binding protein A8	Homo sapiens	30-39
27151304-9	2016	In this study, we demonstrated that ALCAM and MCAM also function as S100A8/A9 receptors as does RAGE and induce malignant melanoma progression by NF-kappaB activation and ROS formation.	ros	171-174	activated leukocyte cell adhesion molecule	Homo sapiens	36-41
29769743-1	2019	Our previous study showed that TP53-induced glycolysis and apoptosis regulator (TIGAR) regulated ROS, autophagy, and apoptosis in response to hypoxia and chemotherapeutic drugs.	ros	97-100	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	31-78
27278553-7	2016	On the contrary, ROS damage decreased by increasing SOD2 gene and protein expression and hydrogen peroxide production with parallel NF-kappaB protein expression decrease in MDA-MB-231, a tumorigenic triple-negative breast cancer cell line.	ros	17-20	superoxide dismutase 2	Homo sapiens	52-56
29564224-5	2018	Furthermore, the IF1-mediated inhibition of the H+-ATP synthase promotes the production of mitochondrial ROS (mtROS).	ros	105-108	ATP synthase inhibitory factor subunit 1	Homo sapiens	17-20
29363860-0	2018	ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway.	ros	102-105	angiotensin converting enzyme 2	Homo sapiens	0-4
29769743-1	2019	Our previous study showed that TP53-induced glycolysis and apoptosis regulator (TIGAR) regulated ROS, autophagy, and apoptosis in response to hypoxia and chemotherapeutic drugs.	ros	97-100	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	80-85
26947057-1	2016	Cu/Zn Superoxide Dismutase (SOD1), the most important antioxidant defense against ROS in eukaryotic cells, localizes in cytosol and intermembrane space of mitochondria (IMS).	ros	82-85	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	28-32
29769743-4	2019	Whether there is a crosstalk between TIGAR and aescin in regulating ROS, autophagy, and apoptosis is unknown.	ros	68-71	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	37-42
26935109-10	2016	POMC-Ptp1b deletion decreased ROS-scavenging enzymes [superoxide dismutases (SODs)] whereas it increased ROS-generating enzymes [NADPH oxidases (NOXs)] and cyclooxygenase-2 (COX-1) expression, in aorta.	ros	30-33	pro-opiomelanocortin-alpha	Mus musculus	0-4
29248592-3	2018	The roles of ROS, intracellular calcium, endoplasmic reticulum (ER), and ERK1/2 were looked at with ROS scavenger N-acetyl-cysteine (NAC), intracellular calcium chelator BAPTA-AM, ER calcium depleting agent thapsigargin (TG), and ERK1/2 inhibitor U0126, respectively.	ros	100-103	mitogen activated protein kinase 3	Rattus norvegicus	73-79
26935109-10	2016	POMC-Ptp1b deletion decreased ROS-scavenging enzymes [superoxide dismutases (SODs)] whereas it increased ROS-generating enzymes [NADPH oxidases (NOXs)] and cyclooxygenase-2 (COX-1) expression, in aorta.	ros	105-108	pro-opiomelanocortin-alpha	Mus musculus	0-4
29415883-4	2018	Notably, DNA-PK activity is suppressed after irradiation when ROS induce the dissociation of DNA-PKcs with Ku70/80, resulting in delayed DNA repair and radiosensitivity; subsequently, after ROS clearance, the accumulated DNA damage and robust activation of DNA-PK induce genomic instability, facilitated by Rad50-mediated cell-cycle arrest, leading to enhanced malignancy, CSC overgrowth, and radioresistance.	ros	62-65	RAD50 double strand break repair protein	Homo sapiens	307-312
29769743-8	2019	Furthermore, aescin-induced ROS elevation and autophagy activation were further strengthened by TIGAR knockdown in HCT-116 cells.	ros	28-31	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	96-101
29366441-7	2018	Furthermore, hypoxia-induced inflammation by HMGB1 translocation into the cytoplasm results in the release of IL-8 through a ROS-dependent mechanism in upper airway epithelium.	ros	125-128	high mobility group box 1	Homo sapiens	45-50
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	Janus kinase 2	Homo sapiens	104-108
26152521-9	2016	Pretreatment of cells with ROS scavenger N-acetyl cysteine abrogated the inhibitory effect of CA on the JAK2-STAT3/Src-STAT3 signaling and rescued cells from CA-induced apoptosis by blocking the induction of p53 and the cleavage of caspase-3 and PARP in HCT116 cells.	ros	27-30	collagen type XI alpha 2 chain	Homo sapiens	246-250
27144436-7	2016	Both NR4A1 knockdown and treatment with DIM-C-pPhOH and DIM-C-pPhCO2Me also induced ROS which activated stress genes and induced sestrin 2 which activated AMPK and inhibited mTOR in the mutant p53 RMS cells.	ros	84-87	sestrin 2	Homo sapiens	129-138
30571927-9	2019	One was from ROS-dependent activation of ATM via AMPK-ULK1-ATG13-Beclin1/ATG5.	ros	13-16	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	49-53
30571927-9	2019	One was from ROS-dependent activation of ATM via AMPK-ULK1-ATG13-Beclin1/ATG5.	ros	13-16	unc-51 like autophagy activating kinase 1	Homo sapiens	54-58
30458278-3	2019	In our previous study, we found that ROS-dependent Atg4B upregulation mediated Cd-induced autophagy and autophagy played an important role in Cd-induced proliferation and invasion in A549 cells.	ros	37-40	autophagy related 4B cysteine peptidase	Homo sapiens	51-56
27171435-5	2016	On the other hand, over-expression of VDAC-1 augmented erastin-induced ROS production, mPTP opening, and colorectal cancer cell apoptosis.	ros	71-74	voltage dependent anion channel 1	Homo sapiens	38-44
27151080-6	2016	Conversely, an increased oxygen consumption and mitochondria hyperpolarization were observed in C9ORF72 fibroblasts in association to increased ROS and ATP content.	ros	144-147	C9orf72-SMCR8 complex subunit	Homo sapiens	96-103
30745846-8	2019	The improved PDT efficacy by Cx43-composed GJIC was correlated with stress signaling pathways mediated by ROS, calcium and lipid peroxide.	ros	106-109	gap junction protein alpha 1	Homo sapiens	29-33
26986073-0	2016	MiR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4.	ros	18-21	NADPH oxidase 4	Homo sapiens	96-100
26986073-8	2016	By targeting NOX4-mediated ROS production, miR-99a regulated the invasion and migration of lung adenocarcinoma cells.	ros	27-30	NADPH oxidase 4	Homo sapiens	13-17
26794444-0	2016	HBV-induced ROS accumulation promotes hepatocarcinogenesis through Snail-mediated epigenetic silencing of SOCS3.	ros	12-15	suppressor of cytokine signaling 3	Homo sapiens	106-111
26794444-4	2016	Here, we showed that the repression of SOCS3 and sustained activation of IL-6/STAT3 pathway in HBV-producing HCC cells were caused by HBV-induced mitochondrial ROS accumulation.	ros	160-163	suppressor of cytokine signaling 3	Homo sapiens	39-44
26794444-5	2016	Mechanistic studies revealed that ROS-mediated DNA methylation resulted in the silencing of SOCS3.	ros	34-37	suppressor of cytokine signaling 3	Homo sapiens	92-97
26794444-7	2016	Further studies revealed that HBV-induced ROS accumulation upregulated the expression of the transcription factor, Snail, which bound to the E-boxes of SOCS3 promoter and mediated the epigenetic silencing of SOCS3 in association with DNMT1 and HDAC1.	ros	42-45	suppressor of cytokine signaling 3	Homo sapiens	152-157
26794444-7	2016	Further studies revealed that HBV-induced ROS accumulation upregulated the expression of the transcription factor, Snail, which bound to the E-boxes of SOCS3 promoter and mediated the epigenetic silencing of SOCS3 in association with DNMT1 and HDAC1.	ros	42-45	suppressor of cytokine signaling 3	Homo sapiens	208-213
26794444-9	2016	Taken together, our data show that HBV-induced mitochondrial ROS production represses SOCS3 expression through Snail-mediated epigenetic silencing, leading to the sustained activation of IL-6/STAT3 pathway and ultimately contributing to hepatocarcinogenesis.	ros	61-64	suppressor of cytokine signaling 3	Homo sapiens	86-91
26860957-5	2016	The increase in levels of inflammatory cytokines/chemokines corresponds to increased levels of ROS/RNS, which is accompanied by increased activities of Akt, ERK1/2, tuberin, down regulation of 8-oxoG-DNA glycosylase (OGG1), and increase in 8-hydroxydeoxyguanosine (8-OHdG) accumulation in DNA.	ros	95-98	mitogen-activated protein kinase 3	Mus musculus	157-163
27011313-7	2016	Enforced BAG3 expression presented similar effects as puerarin pre-treatment in attenuating A/RI in terms of CPK, LDH, MDA, SOD, GSH-Px, ROS generation, and cell viability.	ros	137-140	BAG cochaperone 3	Rattus norvegicus	9-13
26631573-7	2016	Adenoviral-mediated overexpression of GRK2 led to similar increases in ROS production and apoptosis as seen with Iso stimulation.	ros	71-74	G protein-coupled receptor kinase 2	Rattus norvegicus	38-42
26631573-9	2016	Adenoviral-mediated expression of a GRK2 inhibitor prevented ROS production and apoptosis in response to Iso stimulation.	ros	61-64	G protein-coupled receptor kinase 2	Rattus norvegicus	36-40
26775629-8	2016	In BCC/KMC1 cells, the induction of p53 by IMQ was achieved through increased ROS production to stimulate the ATM/ATR-Chk1/Chk2 axis but was not mediated by inducing DNA damage.	ros	78-81	checkpoint kinase 2	Homo sapiens	123-127
26637556-8	2016	The microglial inhibitor minocycline attenuated ANG II-mediated ROS production, yet ANG II effects persisted in PVN single-minded 1-AT1a knockout mice, supporting the contribution of a non-neuronal source (likely microglia) to ANG II-driven ROS production in the PVN.	ros	64-67	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	48-51
26798129-1	2016	GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.	ros	43-46	glucagon like peptide 1 receptor	Homo sapiens	0-5
26798129-1	2016	GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.	ros	105-108	glucagon like peptide 1 receptor	Homo sapiens	0-5
26798130-1	2016	GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.	ros	43-46	glucagon like peptide 1 receptor	Homo sapiens	0-5
26798130-1	2016	GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.	ros	105-108	glucagon like peptide 1 receptor	Homo sapiens	0-5
26707081-4	2016	By inhibiting mTOR and mitochondrial manganese superoxide dismutase (MnSOD), we confirmed that rapamycin functioned through the mTOR/MnSOD/reactive oxygen species (ROS) signaling pathway, and the existence of Akt governed the rapamycin-induced asymmetric division (AD) of stem cells in cases of radiation-treated breast cancer.	ros	164-167	superoxide dismutase 2	Homo sapiens	69-74
26454089-0	2016	Mitochondrial-generated ROS down regulates insulin signaling via activation of the p38MAPK stress response pathway.	ros	24-27	mitogen-activated protein kinase 14	Mus musculus	83-90
26454089-1	2016	Impairment of insulin signaling and hepatic insulin resistance has been attributed to ROS-mediated activation of p38MAPK stress response signaling.	ros	86-89	mitogen-activated protein kinase 14	Mus musculus	113-120
26454089-2	2016	Our research focused on whether (a) ROS generated by mitochondrial electron transport chain complex I (ETC-CI) dysfunction, via the use of Rotenone, inactivates insulin signaling; and (b) the p38MAPK pathway is involved in the ROS-induced impairment of insulin signaling.	ros	227-230	mitogen-activated protein kinase 14	Mus musculus	192-199
26454089-5	2016	Our study suggests that ROS generated by inhibition of ETC CI, promotes hepatic insulin resistance partly via activation of the p38MAPK stress-response pathway.	ros	24-27	mitogen-activated protein kinase 14	Mus musculus	128-135
26884717-12	2016	Taken together, these suggested that CsA could suppress ROS-mediated p53 mitochondrial distribution and cell apoptosis depended on its inhibition effect to mitochondrial permeability transition.	ros	56-59	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	37-40
26788244-8	2016	CONCLUSION: These findings reveal that O-Tyr may induce oxidative damage and hepatic fibrosis via MAPK/TGF-beta1 signaling pathway, in which ROS together with malondialdehyde (MDA) and OPPs act as the pivotal mediators.	ros	141-144	mitogen activated protein kinase 1	Rattus norvegicus	98-102
26506233-6	2015	Mechanistic studies reveal that COX5B silence induces an increase in production of ROS, depolarization of MMP and a decrease in ATP.	ros	83-86	cytochrome c oxidase subunit 5B	Homo sapiens	32-37
26520405-11	2015	BBP significantly increased ROS production (p&lt;0.05) and ROS may be chiefly regulated by NRF-1 and NRF-2 in HepG2 cells under Sirt1 and Sirt3 silenced condition.	ros	59-62	nuclear respiratory factor 1	Homo sapiens	91-96
26609358-10	2015	RESULTS: The results of our studies show that G-CSF administration mitigated TBI-induced decreases in WBC and the suppression of HPC function (CFU-GM) (p &lt; 0.05), whereas G-CSF exacerbated the suppression of long-term HSC engraftment after transplantation one month after TBI (p &lt; 0.05); The increase in HSC damage was associated with increased ROS production, activation of p38 mitogen-activated protein kinase (p38), induction of senescence in HSCs.	ros	351-354	colony stimulating factor 3 (granulocyte)	Mus musculus	46-51
26609358-11	2015	CONCLUSION: Our findings suggest that although G-CSF administration can reduce ARS, it can also exacerbate TBI-induced LT-BM injury in part by promoting HSC senescence via the ROS-p38-p16 pathway.	ros	176-179	colony stimulating factor 3 (granulocyte)	Mus musculus	47-52
26609358-11	2015	CONCLUSION: Our findings suggest that although G-CSF administration can reduce ARS, it can also exacerbate TBI-induced LT-BM injury in part by promoting HSC senescence via the ROS-p38-p16 pathway.	ros	176-179	mitogen-activated protein kinase 14	Mus musculus	180-183
26310940-8	2015	Inhibition of CD40L binding reduced placental ET-1 to 2.3-fold above NP rats and normalized placental ROS from 318.6 +- 89 in NP+RUPP CD4(+) T cells (P &lt; 0.05) to 118.7 +- 24 in NP+RUPP CD4(+) T+anti-CD40L (P &lt; 0.05).	ros	102-105	CD40 ligand	Rattus norvegicus	14-19
25199686-8	2015	Endosulfan-induced Akt/MAPK pathways and COX-2 expression were attenuated by DPI, a specific NOX inhibitor, and the ROS scavenger N-acetylcysteine.	ros	116-119	cytochrome c oxidase II, mitochondrial	Mus musculus	41-46
25199686-9	2015	These results demonstrate that endosulfan induces COX-2 expression via NADPH oxidase, ROS, and Akt/MAPK pathways.	ros	86-89	cytochrome c oxidase II, mitochondrial	Mus musculus	50-55
26212201-0	2015	Resveratrol inhibits TIGAR to promote ROS induced apoptosis and autophagy.	ros	38-41	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	21-26
26212201-2	2015	Here, TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator) was identified as an important target of resveratrol for exhibiting ROS-dependent-consequences on apoptosis and autophagy.	ros	130-133	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	6-11
26212201-2	2015	Here, TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator) was identified as an important target of resveratrol for exhibiting ROS-dependent-consequences on apoptosis and autophagy.	ros	130-133	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	13-60
26367307-4	2015	We used LPS-EK as a specific agonist for TLR4, and PPC and SIN-1 as in situ sources for ROS.	ros	88-91	mitogen-activated protein kinase associated protein 1	Mus musculus	59-64
26539112-7	2015	The levels of tissue ROS and serum inflammatory cytokines were significantly higher in SOD1(G93A) mice compared to control mice, and knocking down peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1alpha) drastically increased cytokine levels in both control and SOD1(G93A) mice.	ros	21-24	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	147-215
26437801-7	2015	Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFalpha in an ATP7A-independent manner.	ros	121-124	intercellular adhesion molecule 1	Mus musculus	141-147
26224570-4	2015	Using primary human macrophages and a murine macrophage cell line, we demonstrate that TWEAK promotes ROS production and enhances NADPH oxidase activity.	ros	102-105	tumor necrosis factor (ligand) superfamily, member 12	Mus musculus	87-92
26224570-5	2015	Hence, we show a direct involvement of the TWEAK-Fn14 axis in oxidative stress, as genetic silencing of Fn14 or Nox2 abrogates the TWEAK-induced ROS production.	ros	145-148	TNF receptor superfamily member 12A	Homo sapiens	49-53
26224570-5	2015	Hence, we show a direct involvement of the TWEAK-Fn14 axis in oxidative stress, as genetic silencing of Fn14 or Nox2 abrogates the TWEAK-induced ROS production.	ros	145-148	TNF receptor superfamily member 12A	Homo sapiens	104-108
26387735-3	2015	We identified a necessary and conserved role for spastic paraplegia 7 (SPG7) in Ca(2+)- and ROS-induced PTP opening using RNAi-based screening.	ros	92-95	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	49-69
26387735-3	2015	We identified a necessary and conserved role for spastic paraplegia 7 (SPG7) in Ca(2+)- and ROS-induced PTP opening using RNAi-based screening.	ros	92-95	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	71-75
26387735-6	2015	Silencing or disruption of SPG7-CypD binding prevented Ca(2+)- and ROS-induced DeltaPsim depolarization and cell death.	ros	67-70	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	27-31
26198315-10	2015	The levels of reactive oxygen and nitrogen species (ROS/RNS) between MDR and non-MDR cells significantly differed upon exposure to 6, accompanied by changes in the glutathione (GSH) levels and in the expression of manganese superoxide dismutase (MnSOD), glutathione-S-transferase pi (GST pi) and hypoxia-inducible factor-1alpha (HIF-1alpha).	ros	52-55	superoxide dismutase 2	Homo sapiens	214-244
25956196-0	2015	Cloning and characterization of two lipopolysaccharide-binding protein/bactericidal permeability-increasing protein (LBP/BPI) genes from the sea cucumber Apostichopus japonicus with diversified function in modulating ROS production.	ros	217-220	lipopolysaccharide-binding protein	Cucumis sativus	117-120
25960046-2	2015	Uncoupling protein 2 (UCP2) may play a dual role in cancer, acting as a protective mechanism in normal cells, while its overexpression in cancer cells could confer resistance to chemotherapy and a higher survival through downregulation of ROS production.	ros	239-242	uncoupling protein 2	Homo sapiens	0-20
25960046-2	2015	Uncoupling protein 2 (UCP2) may play a dual role in cancer, acting as a protective mechanism in normal cells, while its overexpression in cancer cells could confer resistance to chemotherapy and a higher survival through downregulation of ROS production.	ros	239-242	uncoupling protein 2	Homo sapiens	22-26
25960046-6	2015	UCP2 inhibition and cytotoxic treatments produced a decrease in cell viability and clonogenicity, in addition to an increase in DeltaPsim, ROS production, apoptosis, and autophagy.	ros	139-142	uncoupling protein 2	Homo sapiens	0-4
26248074-3	2015	UCP2, a mitochondrial membrane protein, which influences cardiac ROS formation was reported to interact with the MCU.	ros	65-68	mitochondrial calcium uniporter	Mus musculus	113-116
26314448-7	2015	CONCLUSION: PDI participates in the induced GPIbalpha ectodomein shedding, and the effect of PDI in this process maybe depend on the change of ROS level inside platelets.	ros	143-146	prolyl 4-hydroxylase subunit beta	Homo sapiens	12-15
26314448-7	2015	CONCLUSION: PDI participates in the induced GPIbalpha ectodomein shedding, and the effect of PDI in this process maybe depend on the change of ROS level inside platelets.	ros	143-146	prolyl 4-hydroxylase subunit beta	Homo sapiens	93-96
26156213-0	2015	Galangin attenuates airway remodelling by inhibiting TGF-beta1-mediated ROS generation and MAPK/Akt phosphorylation in asthma.	ros	72-75	transforming growth factor, beta 1	Mus musculus	53-62
26156213-9	2015	Consistently, the TGF-beta1-induced proliferation of airway smooth muscle cells was reduced by galangin in vitro, which might be due to the alleviation of ROS levels and inhibition of MAPK pathway.	ros	155-158	transforming growth factor, beta 1	Mus musculus	18-27
26156213-10	2015	Taken together, the present findings highlight a novel role for galangin as a promising anti-remodelling agent in asthma, which likely involves the TGF-beta1-ROS-MAPK pathway.	ros	158-161	transforming growth factor, beta 1	Mus musculus	148-157
26047104-9	2015	Calpain-1 suppression also decreased the activity, mRNA and protein expression of ALP and reduced the mitochondrial ROS (Mito-ROS) production in RVSMCs.	ros	116-119	calpain 1	Rattus norvegicus	0-9
25896763-7	2015	Furthermore, inhibition of ROS activity by N-acetyl-l-cysteine (NAC) eliminated the OGD-induced increase in TRPC6 expression and Ca(2+) influx.	ros	27-30	transient receptor potential cation channel subfamily C member 6	Homo sapiens	108-113
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	NADPH oxidase 4	Homo sapiens	86-101
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	NADPH oxidase 4	Homo sapiens	103-107
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	64-67	NADPH oxidase 4	Homo sapiens	86-101
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	64-67	NADPH oxidase 4	Homo sapiens	103-107
25704631-10	2015	The expression of mitochondrium-specific antioxidant enzyme, SOD2, is reduced which may limit the ROS scavenging ability and cause imbalance of the mitochondrial ROS homeostasis.	ros	98-101	superoxide dismutase 2	Homo sapiens	61-65
25704631-10	2015	The expression of mitochondrium-specific antioxidant enzyme, SOD2, is reduced which may limit the ROS scavenging ability and cause imbalance of the mitochondrial ROS homeostasis.	ros	162-165	superoxide dismutase 2	Homo sapiens	61-65
29277696-10	2018	Cytochalasin B (Cyt B) inhibited the ZA-induced ROS/RNS production, but could not change the ROS/RNS level stimulated by LPS.	ros	48-51	CYTB	Macrobrachium rosenbergii	16-21
29395065-8	2018	This study demonstrates a novel regulatory function of Nur77 with linkage of the FAO-NADPH-ROS pathway during metabolic stress, suggesting Nur77 as a potential therapeutic target in melanoma.	ros	91-94	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	55-60
29395065-8	2018	This study demonstrates a novel regulatory function of Nur77 with linkage of the FAO-NADPH-ROS pathway during metabolic stress, suggesting Nur77 as a potential therapeutic target in melanoma.	ros	91-94	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	139-144
29552311-9	2018	We therefore demonstrated that miR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1/ROS/JNK pathway.	ros	111-114	microRNA 29b-1	Homo sapiens	31-38
30178377-9	2018	Cytokine stimulation was found to differentially affect gene expression of major ROS synthesizing enzymes: eNOS was decreased whereas COX-2 and NOX-4 were increased.	ros	81-84	NADPH oxidase 4	Homo sapiens	144-149
30062975-6	2018	RESULTS: Gedunin and the AR inhibitor epalrestat inhibited AR expression and ROS generation.	ros	77-80	aldo-keto reductase family 1 member B1	Rattus norvegicus	25-27
30062975-11	2018	CONCLUSION: Inhibition of AR-mediated ROS signalling may be a key mechanism by which gedunin and epalrestat exert their anticancer effects.	ros	38-41	aldo-keto reductase family 1 member B1	Rattus norvegicus	26-28
29165041-6	2018	The Ser34 phosphorylation of ATG4B also contributed to the impairment of mitochondrial activity including the inhibition of F1Fo-ATP synthase activity and the elevation of mitochondrial ROS in HCC cells.	ros	186-189	autophagy related 4B cysteine peptidase	Homo sapiens	29-34
29224514-7	2018	Our results suggested that the combination of the SRO1 and GPX3 may be contributed to plant response to mercury stress by regulating ROS intracellular oxidative homeostasis.	ros	133-136	glutathione peroxidase 3	Arabidopsis thaliana	59-63
28549109-6	2018	Further investigation revealed that the rapid inflammasome-dependent activation of IL-18, but not IL-1beta, was the critical up-stream regulator for elevated chemokine expression in the myocardium upon ISO induced beta1-AR-ROS signalling.	ros	223-226	adrenoceptor beta 1	Homo sapiens	214-222
28295305-5	2018	We found that MAPK signaling pathways, especially ERK1/2, participated in modulating AT1 R gene expression through DOX-induced mitochondrial ROS release.	ros	141-144	angiotensin II receptor type 1	Homo sapiens	85-90
30380548-2	2018	AT1-AA has been shown to enhance the effect of AngII in pre-eclampsia, such as production of endothelin-1, activation of ROS, and vasoconstriction, which are considered to be associated with hypertension; however, whether or not AT1-AA participates in podocyte damage leading to the generation of proteinuria has not been reported.	ros	121-124	angiotensin II receptor type 1	Homo sapiens	0-3
29176870-11	2017	The analysis of Ecmdar overexpressing Arabidopsis transgenic lines suggests that monodehydroascorbate reductase acts as a key stress regulator by modulating the activity of antioxidant enzymes to strengthen the ROS scavenging ability and maintains ROS homeostasis.	ros	211-214	monodehydroascorbate reductase	Arabidopsis thaliana	81-111
29176870-11	2017	The analysis of Ecmdar overexpressing Arabidopsis transgenic lines suggests that monodehydroascorbate reductase acts as a key stress regulator by modulating the activity of antioxidant enzymes to strengthen the ROS scavenging ability and maintains ROS homeostasis.	ros	248-251	monodehydroascorbate reductase	Arabidopsis thaliana	81-111
29169374-11	2017	Silencing ID1 expression blocked the activation of G6PD, decreased the production of PPP NADPH, and augmented reactive oxygen and species (ROS), thus inducing cell apoptosis.	ros	139-142	inhibitor of DNA binding 1, HLH protein	Homo sapiens	10-13
29312589-6	2017	G6PD up-regulated ROS generation by facilitating NADPH-dependent NOX4 activation, which led to increased expression of p-STAT3 and CyclinD1.	ros	18-21	cyclin D1	Homo sapiens	131-139
29312589-7	2017	Enhanced ROS generation rescued the p-STAT3 and CyclinD1 expression reduction in G6PD-knockdown cells, while ROS scavengers reversed the up-regulated p-STAT3 and CyclinD1 expression in G6PD-overexpressing cells.	ros	9-12	cyclin D1	Homo sapiens	48-56
28935467-6	2017	While inhibition of HK2 either by Lonidamine or siRNA further elevated PMA induced Chibby, mitochondrial ROS, TIGAR and LC3II levels; siRNA mediated knock-down of SIRT6 exhibited contradictory effects as compared to HK2.	ros	105-108	hexokinase 2	Homo sapiens	20-23
28774732-12	2017	Taken together, these results indicate that downregulation of TIGAR increased PB-induced apoptosis and autophagosomes associated cell death through promoting ROS generation in MDA-MB-231 and MCF-7 cells.	ros	158-161	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	62-67
28946937-6	2017	The ROS scavenger N-acetylcysteine inhibited CLB2.0-induced IL-6 secretion, thereby decreasing the CLB2.0-induced MUC5AC expression, whereas CLB2.0-induced MUC1 expression increased.	ros	4-7	mucin 1, cell surface associated	Homo sapiens	156-160
28806702-9	2017	In conclusion, as sepsis worsens, ROS generation and HMGB1 oxidation increases in kidney cells, which enhances HMGB1"s pro-inflammatory signaling.	ros	34-37	high mobility group box 1	Mus musculus	111-116
28806703-0	2017	NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.	ros	14-17	NADPH oxidase 4	Homo sapiens	0-4
28806703-10	2017	Therefore, we demonstrated that thioridazine plus curcumin induces proteasome activity by up-regulating PSMA5 expression via NOX4-mediated ROS production and that down-regulation of c-FLIP and Mcl-1 expression post-translationally is involved in apoptosis.	ros	139-142	NADPH oxidase 4	Homo sapiens	125-129
28906491-0	2017	Cystatin SN inhibits auranofin-induced cell death by autophagic induction and ROS regulation via glutathione reductase activity in colorectal cancer.	ros	78-81	cystatin SN	Homo sapiens	0-11
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	33-36	high mobility group box 1	Homo sapiens	77-82
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	33-36	high mobility group box 1	Homo sapiens	108-113
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	91-94	high mobility group box 1	Homo sapiens	77-82
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	91-94	high mobility group box 1	Homo sapiens	108-113
28852176-0	2017	A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells.	ros	58-61	sperm associated antigen 5	Mus musculus	28-31
28852176-0	2017	A novel chalcone derivative S17 induces apoptosis through ROS dependent DR5 up-regulation in gastric cancer cells.	ros	58-61	tumor necrosis factor receptor superfamily, member 10b	Mus musculus	72-75
28852176-6	2017	S17 robustly induced generation of ROS with Keap/Nrf2 pathway activated and the application of ROS scavenger N-acetyl cysteine (NAC) completely blocked these effects by S17 in MGC803 cells.	ros	35-38	sperm associated antigen 5	Mus musculus	0-3
28852176-6	2017	S17 robustly induced generation of ROS with Keap/Nrf2 pathway activated and the application of ROS scavenger N-acetyl cysteine (NAC) completely blocked these effects by S17 in MGC803 cells.	ros	95-98	sperm associated antigen 5	Mus musculus	169-172
28768915-4	2017	Doxorubicin increased production of ROS in rodent cardiomyocytes through hypoxic stress-mediated upregulation of NADPH oxidase 2 (Nox2), which formed a stable complex with TRPC3.	ros	36-39	cytochrome b-245, beta polypeptide	Mus musculus	113-128
28768915-4	2017	Doxorubicin increased production of ROS in rodent cardiomyocytes through hypoxic stress-mediated upregulation of NADPH oxidase 2 (Nox2), which formed a stable complex with TRPC3.	ros	36-39	cytochrome b-245, beta polypeptide	Mus musculus	130-134
28366813-8	2017	The expression of MITA decreased mitochondrial number and enhances mitochondrial ROS by increasing complex-I activity.	ros	81-84	stimulator of interferon response cGAMP interactor 1	Homo sapiens	18-22
28323129-0	2017	Peroxiredoxin 2 regulates PGF2alpha-induced corpus luteum regression in mice by inhibiting ROS-dependent JNK activation.	ros	91-94	peroxiredoxin 2	Mus musculus	0-15
28323129-7	2017	We found that PGF2alpha-induced ROS generation was significantly higher in Prx2-/- MEF cells compared with that in wild-type (WT) cells, which induced apoptosis by activating JNK-mediated apoptotic signaling pathway.	ros	32-35	peroxiredoxin 2	Mus musculus	75-79
28323129-11	2017	This is the first study to demonstrate that Prx2 deficiency ultimately accelerated the PGF2alpha-induced luteal regression through activation of the ROS-dependent JNK pathway.	ros	149-152	peroxiredoxin 2	Mus musculus	44-48
28323129-12	2017	These findings suggest that Prx2 plays a crucial role in preventing accelerated luteal regression via inhibition of the ROS/JNK pathway.	ros	120-123	peroxiredoxin 2	Mus musculus	28-32
28661486-2	2017	ROS production from mitochondria activates MAP3 kinases, such as MLK3 and ASK1, which continue to activate a pathway to sustain JNK activation, and amplifies the toxic effect of acetaminophen (APAP) and TNF/galactosamine (TNF/GalN).	ros	0-3	mitogen-activated protein kinase kinase kinase 11	Mus musculus	65-69
28528741-0	2017	In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages: A role for the ROS-relative TLR4/MyD88 signaling pathway.	ros	89-92	MYD88 innate immune signal transduction adaptor	Homo sapiens	107-112
28528741-9	2017	These data indicate that OTA induced immune toxicity via ROS-relative TLR4/MyD88 signaling pathway in PAMs.	ros	57-60	MYD88 innate immune signal transduction adaptor	Homo sapiens	75-80
28595650-13	2017	qPCR and IHC analysis revealed that expression of microglial NOX2, a ROS-producing enzyme, was significantly increased correlating with AIS disruption.	ros	69-72	cytochrome b-245, beta polypeptide	Mus musculus	61-65
28595650-14	2017	Furthermore, ablation of NOX2 prevented inflammation-induced AIS plasticity, suggesting that ROS drive AIS structural plasticity.	ros	93-96	cytochrome b-245, beta polypeptide	Mus musculus	25-29
28537474-6	2017	ERF71 and ERF73 may have a role in supervising plant intracellular ROS homeostasis, whereas ERF72 may only act as an activator of ERF74 and ERF75 in the stress response.	ros	67-70	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	0-5
28216619-10	2017	Furthermore, 15d-PGJ2 pretreatment activated Nrf2 and inhibited a ROS/HIF1alpha/BNIP3 pathway in the livers.	ros	66-69	BCL2/adenovirus E1B interacting protein 3	Mus musculus	80-85
28346230-6	2017	GLS1 inhibitor-induced nucleoside depletion and ROS enhancement led to DNA replication stress and activation of an intra-S phase checkpoint, and suppressed the growth of VHL-/- RCC cells.	ros	48-51	von Hippel-Lindau tumor suppressor	Homo sapiens	170-173
27021021-17	2017	SCOP can result in augmented ROS release in hippocampal neurons, leading to Ca2+ uptake through TRPM2 and TRPV1 channels.	ros	29-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	106-111
27805282-2	2017	We have shown here that TLR3 activation can induce metabolic reprogramming in a pharyngeal cancer cell line, leading to increased aerobic glycolysis, cell migration, elevated levels of reactive oxidative species (ROS), and decreased anti-oxidative response.	ros	213-216	toll like receptor 3	Homo sapiens	24-28
28301876-7	2017	The mechanism may be related to the inhibition of QBC939 cells with higher activity of the PPP, the key enzyme G6PDH, which reduces the antioxidant capacity of cells and increases intracellular ROS, especially mitochondrial ROS.	ros	194-197	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	111-116
28301876-7	2017	The mechanism may be related to the inhibition of QBC939 cells with higher activity of the PPP, the key enzyme G6PDH, which reduces the antioxidant capacity of cells and increases intracellular ROS, especially mitochondrial ROS.	ros	224-227	hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase	Homo sapiens	111-116
28190775-6	2017	In Drp1fl/fl-POMC-cre:ERT2 mice, POMC neurons showed increased mitochondrial size, ROS production, and neuronal activation with increased expression of Kcnj11 mRNA regulated by peroxisome proliferator-activated receptor (PPAR).	ros	83-86	pro-opiomelanocortin-alpha	Mus musculus	13-17
28190775-6	2017	In Drp1fl/fl-POMC-cre:ERT2 mice, POMC neurons showed increased mitochondrial size, ROS production, and neuronal activation with increased expression of Kcnj11 mRNA regulated by peroxisome proliferator-activated receptor (PPAR).	ros	83-86	mitogen-activated protein kinase 3	Mus musculus	22-26
28190775-6	2017	In Drp1fl/fl-POMC-cre:ERT2 mice, POMC neurons showed increased mitochondrial size, ROS production, and neuronal activation with increased expression of Kcnj11 mRNA regulated by peroxisome proliferator-activated receptor (PPAR).	ros	83-86	pro-opiomelanocortin-alpha	Mus musculus	33-37
28120377-0	2017	A Boronic Acid Conjugate of Angiogenin that Shows ROS-Responsive Neuroprotective Activity.	ros	50-53	angiogenin	Homo sapiens	28-38
28088327-8	2017	ROS levels were partially reduced by incubation with PP2 (c-Src inhibitor) or IL1RN, and further reduced by using the NOX1/4 inhibitor GKT137831.	ros	0-3	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	53-56
28088327-8	2017	ROS levels were partially reduced by incubation with PP2 (c-Src inhibitor) or IL1RN, and further reduced by using the NOX1/4 inhibitor GKT137831.	ros	0-3	NADPH oxidase 1	Homo sapiens	118-122
27253713-7	2017	Nox2-deficient T cells also showed hyperactivation, reduced AICD, and diminished Treg-cell differentiation through increased AKT phosphorylation (T308/S473) and enhanced mitochondrial ROS production.	ros	184-187	cytochrome b-245, beta polypeptide	Mus musculus	0-4
28075404-17	2017	Both ROS production and RAW264.7 differentiation into DC-like cells induced by HSA-AOPP were reduced by NAC.	ros	5-8	peroxiredoxin 5	Mus musculus	83-87
28067240-5	2017	Co-culture with CD8+ T cells upregulates NCC in mouse DCT cells via ROS-induced activation of Src kinase, up-regulation of the K+ channel Kir4.1, and stimulation of the Cl- channel ClC-K.	ros	68-71	potassium inwardly-rectifying channel, subfamily J, member 10	Mus musculus	138-144
28069043-8	2017	RESULTS: We showed that FGF19, when overexpressed, inhibited the effect of sorafenib on ROS generation and apoptosis in HCC.	ros	88-91	fibroblast growth factor 19	Homo sapiens	24-29
28069043-9	2017	In contrast, loss of FGF19 or its receptor FGFR4 led to a remarkable increase in sorafenib-induced ROS generation and apoptosis.	ros	99-102	fibroblast growth factor receptor 4	Homo sapiens	43-48
28069043-11	2017	Importantly, targeting FGF19/FGFR4 axis by ponatinib, a third-generation inhibitor of chronic myeloid leukemia, overcomes HCC resistance of sorafenib by enhancing ROS-associated apoptosis in sorafenib-treated HCC.	ros	163-166	fibroblast growth factor 19	Homo sapiens	23-28
28069043-11	2017	Importantly, targeting FGF19/FGFR4 axis by ponatinib, a third-generation inhibitor of chronic myeloid leukemia, overcomes HCC resistance of sorafenib by enhancing ROS-associated apoptosis in sorafenib-treated HCC.	ros	163-166	fibroblast growth factor receptor 4	Homo sapiens	29-34
28567457-0	2017	SIRT3-SOD2-ROS pathway is involved in linalool-induced glioma cell apoptotic death.	ros	11-14	superoxide dismutase 2	Homo sapiens	6-10
29237157-12	2017	To determine a major route of ROS production, we tested whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is involved in hypoxia-induced ROS production.	ros	30-33	NADPH oxidase 4	Homo sapiens	127-131
29237157-12	2017	To determine a major route of ROS production, we tested whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is involved in hypoxia-induced ROS production.	ros	164-167	NADPH oxidase 4	Homo sapiens	64-125
29237157-12	2017	To determine a major route of ROS production, we tested whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) is involved in hypoxia-induced ROS production.	ros	164-167	NADPH oxidase 4	Homo sapiens	127-131
29237157-14	2017	Furthermore, siRNA-mediated knockdown of NOX4 expression abolished hypoxia induced ROS generation and GLI1-dependent activation and invasion of HCC cells.	ros	83-86	NADPH oxidase 4	Homo sapiens	41-45
29237157-15	2017	CONCLUSION: Our findings indicate that hypoxia triggers ROS-mediated GLI1-dependent EMT progress and invasion of HCC cells through induction of NOX4 expression.	ros	56-59	NADPH oxidase 4	Homo sapiens	144-148
28751937-10	2017	Myricitrin attenuated the generation of intracellular ROS by inhibiting the assembly of components of the gp91phox and p47phox.	ros	54-57	cytochrome b-245, beta polypeptide	Mus musculus	106-114
28751937-11	2017	Suppression of ROS generation using NAC or apocynin or by silencing gp91phox and p47phox all demonstrated that decreasing the level of ROS inhibited the LPS-induced inflammatory response.	ros	135-138	cytochrome b-245, beta polypeptide	Mus musculus	68-76
28751937-12	2017	Collectively, these results confirmed that myricitrin exhibited anti-inflammatory activity by blocking the activation of JAKs and the downstream transcription factor STAT1, which may result from the downregulation of NOX2-dependent ROS production mediated by myricitrin.	ros	232-235	cytochrome b-245, beta polypeptide	Mus musculus	217-221
29129986-2	2017	Ghrelin administration is expected to reduce ROS, preventing the onset of different diseases.	ros	45-48	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
29129986-5	2017	The results showed that pretreatment with ghrelin reduced H2O2-induced cellular apoptosis and ROS accumulation, increased the expression levels of SOD and CAT, and decreased the expression level of MDA.	ros	94-97	ghrelin and obestatin prepropeptide	Rattus norvegicus	42-49
27989748-6	2016	Furthermore, we demonstrated that NOX4-induced glycolysis probably via ROS/PI3K/Akt signaling-dependent c-Myc upregulation.	ros	71-74	NADPH oxidase 4	Homo sapiens	34-38
27601624-11	2016	Finally, we confirmed that IRF4 expression in MDSCs can modulate their activity to inhibit T cell proliferation through IL-10 production and ROS generation, and myeloid-specific deletion of IRF4 leads to the increase of MDSC differentiation.	ros	141-144	interferon regulatory factor 4	Homo sapiens	27-31
27631550-5	2016	In addition, PC12 cells were treated with miR-22 mimics or inhibitor following 6-OHDA administration, which medicated ROS production and upregulation or downregulation of caspase-3 activity, respectively.	ros	118-121	microRNA 22	Rattus norvegicus	42-48
27907115-6	2016	B. melitensis 16M activated the NLRP3/AIM2 inflammatory complex, and induced RAW264.7 cells to secrete IL-1beta and IL-18 through the ROS pathway.	ros	134-137	interleukin 18	Mus musculus	116-121
27876813-0	2016	Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism.	ros	94-97	programmed cell death 4	Homo sapiens	135-140
27620662-18	2016	CONCLUSIONS: Nrf2, an EC protective system, suppresses monocyte adhesion events via the inhibition of the ROS - TNF-alpha - p38 - VCAM-1 pathway following treatment with PNS, with Rb1 specifically playing an important role among PNS active components.	ros	106-109	RB transcriptional corepressor 1	Homo sapiens	180-183
27638049-4	2016	Following ATO treatment, ATF4 activates NADPH oxidase by promoting assembly of the enzyme components Rac-1/P47phox/P67phox, which generates ROS/superoxides.	ros	140-143	neutrophil cytosolic factor 2	Homo sapiens	115-122
27599716-7	2016	Recruitment of Drp1 to mitochondria led to ROS generation and mitochondrial fission, accompanied by dysfunction of mitochondria such as loss of membrane potential and ATP production.	ros	43-46	collapsin response mediator protein 1	Homo sapiens	15-19
27599716-8	2016	ROS generation and mitochondrial dysfunction by Abeta were attenuated when treated with Mdivi-1, a selective Drp1 inhibitor.	ros	0-3	collapsin response mediator protein 1	Homo sapiens	109-113
27596816-11	2016	Ectopic expression of miR-15a, miR-16, increased mitochondrial ROS resulting in impaired mitochondrial membrane potential, followed by cytochrome-C release into the cytosol that activated Caspase-3 and Caspase-6/9 leading to intrinsic apoptosis.	ros	63-66	microRNA 15a	Homo sapiens	22-29
25843721-4	2015	Acute inactivation of E4F1 in these cells results in CHK1-dependent checkpoint deficiency and multiple mitochondrial dysfunctions that lead to increased ROS production, energy stress, and inhibition of de novo pyrimidine synthesis.	ros	153-156	E4F transcription factor 1	Homo sapiens	22-26
25835394-5	2015	CE induced the expression of HO-1 as well as C-reactive protein (CRP) and NADPH oxidase 4 (NOX4), which are associated with ROS production.	ros	124-127	NADPH oxidase 4	Homo sapiens	74-89
25835394-5	2015	CE induced the expression of HO-1 as well as C-reactive protein (CRP) and NADPH oxidase 4 (NOX4), which are associated with ROS production.	ros	124-127	NADPH oxidase 4	Homo sapiens	91-95
25835394-11	2015	These observations suggest that CE activates CRP and NOX4-mediated ROS production, alters permeability by inhibition of junctional proteins, and leads to caspase-3 dependent apoptosis of epithelial cells, while HO-1 and its reaction products protect against oxidative stress and apoptosis.	ros	67-70	NADPH oxidase 4	Homo sapiens	53-57
25484314-8	2015	Analysis of the mRNA expression levels of the two NOX isoforms implicated in brain pathology showed, that NOX2 is dramatically upregulated under conditions of Nrf2 deficiency, whereas NOX4 is upregulated when Nrf2 is constitutively activated (Keap1-KD) to a degree which paralleled the increases in ROS production.	ros	299-302	NADPH oxidase 4	Homo sapiens	184-188
25312864-11	2015	Additionally, we demonstrated that MRP8/14 promoted autophagy in a ROS-dependent manner.	ros	67-70	ATP binding cassette subfamily C member 8	Homo sapiens	35-39
25312864-12	2015	CONCLUSIONS: The present study revealed a novel role of MRP8/14 in the autophagy-mediated elimination of intracellular BCG by promoting ROS generation, which may provide a promising therapeutic target for tuberculosis and other intracellular bacterial infectious diseases.	ros	136-139	ATP binding cassette subfamily C member 8	Homo sapiens	56-60
25785991-8	2015	In lung epithelial cells, TGF-beta1 induced mitochondrial depolarization, mitochondrial ROS, and PINK1 expression; all were abrogated by mitochondrial ROS scavenging.	ros	88-91	transforming growth factor, beta 1	Mus musculus	26-35
25785991-8	2015	In lung epithelial cells, TGF-beta1 induced mitochondrial depolarization, mitochondrial ROS, and PINK1 expression; all were abrogated by mitochondrial ROS scavenging.	ros	151-154	transforming growth factor, beta 1	Mus musculus	26-35
25785991-10	2015	CONCLUSION: TGF-beta1 induces lung epithelial cell mitochondrial ROS and depolarization and stabilizes the key mitophagy initiating protein, PINK1.	ros	65-68	transforming growth factor, beta 1	Mus musculus	12-21
25849639-6	2015	max2 mutant phenotype was associated with constitutively increased stomatal conductance and decreased tolerance to apoplastic ROS but also with alterations in hormonal balance.	ros	126-129	RNI-like superfamily protein	Arabidopsis thaliana	0-4
25849639-9	2015	Additional factors contributing to pathogen susceptibility in max2 plants include decreased tolerance to pathogen-triggered apoplastic ROS and alterations in hormonal signaling.	ros	135-138	RNI-like superfamily protein	Arabidopsis thaliana	62-66
25434519-5	2015	Mdivi-1 and silencing Drp1 also efficiently prevented cisplatin-induced MMP decrease, ROS production and apoptosis in MDA-MB-231 cells.	ros	86-89	collapsin response mediator protein 1	Homo sapiens	22-26
25434832-5	2015	HMGB1-triggered cell death is associated with intracellular ROS release, and overexpression of Bcl-2 blocks both the increase of ROS as well as HMGB1-dependent cell death.	ros	60-63	high mobility group box 1	Homo sapiens	0-5
25434832-5	2015	HMGB1-triggered cell death is associated with intracellular ROS release, and overexpression of Bcl-2 blocks both the increase of ROS as well as HMGB1-dependent cell death.	ros	129-132	high mobility group box 1	Homo sapiens	0-5
25600142-7	2015	Mechanistically, absence of PECAM-1 resulted in elevated NO/ROS signaling and NRG-1 release from ECs, which resulted in augmented phosphorylation of its receptor ErbB2.	ros	60-63	platelet/endothelial cell adhesion molecule 1	Mus musculus	28-35
26356408-1	2015	UCP2 plays a physiological role by regulating mitochondrial biogenesis, maintaining energy balance, ROS elimination, and regulating cellular autophagy in numerous tissues.	ros	100-103	uncoupling protein 2	Homo sapiens	0-4
26356408-5	2015	The levels of ROS and Mn-SOD were markedly elevated after UCP2 inhibited Genipin.	ros	14-17	uncoupling protein 2	Homo sapiens	58-62
26356408-10	2015	This study indicated that UCP2 is expressed in human cumulus cells and plays important roles on mediate ROS production, apoptotic process, and steroidogenesis, suggesting UCP2 may be involved in regulation of follicle development and oocyte maturation and quality.	ros	104-107	uncoupling protein 2	Homo sapiens	26-30
26313705-8	2015	We found that Sestrin2 silencing strongly inhibits cytokine-induced cell death through a mechanism independent of ROS and mTORC1 regulation.	ros	114-117	sestrin 2	Homo sapiens	14-22
26391545-0	2015	UPP mediated Diabetic Retinopathy via ROS/PARP and NF-kappaB inflammatory factor pathways.	ros	38-41	uridine phosphorylase 1	Homo sapiens	0-3
26391545-3	2015	To investigate whether UPP activated ROS/PARP and NF-kappaB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (DeltaPsim) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.	ros	37-40	uridine phosphorylase 1	Homo sapiens	23-26
26391545-5	2015	The UPP inhibitor and UbshRNA could attenuate these effects through inhibiting the pathway of ROS/PARP and the expression of NF-kappaB inflammatory factors, and the increased UPP was a result of high glucose-induced increase of ROS generation and NF-kappaBp65 expression, accompanied with the decrease of DeltaPsim.	ros	94-97	uridine phosphorylase 1	Homo sapiens	4-7
26391545-5	2015	The UPP inhibitor and UbshRNA could attenuate these effects through inhibiting the pathway of ROS/PARP and the expression of NF-kappaB inflammatory factors, and the increased UPP was a result of high glucose-induced increase of ROS generation and NF-kappaBp65 expression, accompanied with the decrease of DeltaPsim.	ros	228-231	uridine phosphorylase 1	Homo sapiens	4-7
26391545-5	2015	The UPP inhibitor and UbshRNA could attenuate these effects through inhibiting the pathway of ROS/PARP and the expression of NF-kappaB inflammatory factors, and the increased UPP was a result of high glucose-induced increase of ROS generation and NF-kappaBp65 expression, accompanied with the decrease of DeltaPsim.	ros	228-231	uridine phosphorylase 1	Homo sapiens	175-178
26391545-7	2015	It has been indicated that the pathogenic effect of UPP on DR was involved in the increase of ROS generation and NF-kappaB expression, which associated with the ROS/PARP and NF-kappaB inflammatory factor pathways.	ros	94-97	uridine phosphorylase 1	Homo sapiens	52-55
26391545-7	2015	It has been indicated that the pathogenic effect of UPP on DR was involved in the increase of ROS generation and NF-kappaB expression, which associated with the ROS/PARP and NF-kappaB inflammatory factor pathways.	ros	161-164	uridine phosphorylase 1	Homo sapiens	52-55
25453580-8	2015	Moreover, CR3 signalling through focal adhesion kinase (FAK) was indispensable for beta-glucan-mediated ROS production and cytokine production in neutrophils and macrophages, while the Syk-dependent pathway was only partly involved in these responses.	ros	104-107	protein tyrosine kinase 2	Homo sapiens	33-54
25453580-8	2015	Moreover, CR3 signalling through focal adhesion kinase (FAK) was indispensable for beta-glucan-mediated ROS production and cytokine production in neutrophils and macrophages, while the Syk-dependent pathway was only partly involved in these responses.	ros	104-107	protein tyrosine kinase 2	Homo sapiens	56-59
26495010-12	2015	Its mechanism is mediated by the regulation of MAPK signaling pathway and the production of ROS.	ros	92-95	mitogen activated protein kinase 3	Rattus norvegicus	47-51
25201588-7	2014	NNMT may play a vital role in energy balance and ROS induction.	ros	49-52	nicotinamide N-methyltransferase	Homo sapiens	0-4
24769119-0	2014	ROS production in brown adipose tissue mitochondria: the question of UCP1-dependence.	ros	0-3	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	69-73
24769119-1	2014	Whether active UCP1 can reduce ROS production in brown-fat mitochondria is presently not settled.	ros	31-34	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	15-19
24769119-3	2014	We therefore undertook a comprehensive investigation of the significance of UCP1 for ROS production, by comparing the ROS production in brown-fat mitochondria isolated from wildtype mice (that display membrane depolarization) or from UCP1(-/-) mice (with a high membrane potential).	ros	85-88	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	76-80
24769119-4	2014	We tested the significance of UCP1 for glycerol-3-phosphate-supported ROS production by three methods (fluorescent dihydroethidium and the ESR probe PHH for superoxide, and fluorescent Amplex Red for hydrogen peroxide), and followed ROS production also with succinate, acyl-CoA or pyruvate as substrate.	ros	70-73	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	30-34
24769119-8	2014	We conclude that only ROS production supported by exogenously added succinate was affected by the presence of active UCP1; ROS production supported by any other tested substrate (including endogenously generated succinate) was unaffected.	ros	22-25	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	117-121
25091502-10	2014	CONCLUSIONS AND IMPLICATIONS: ET-1 stimulates ETA -mediated NADPH oxidase-dependent ROS generation, which inhibits endothelial NO bioavailability and contributes to ET-1-induced contraction in healthy penile arteries.	ros	84-87	endothelin receptor type A	Rattus norvegicus	46-49
25026091-3	2014	MLP treatments ameliorate Hi-Glc-induced negative effects by a 40% reduction in ROS production, 34-44% reduction in MDA production, over 35% inhibition of NF-kappaB activation, as well as exert protective effect on HepG2 cells from change in DeltaPsim.	ros	80-83	cysteine and glycine rich protein 3	Homo sapiens	0-3
25193743-0	2014	alpha-Lipoic acid protected cardiomyoblasts from the injury induced by sodium nitroprusside through ROS-mediated Akt/Gsk-3beta activation.	ros	100-103	glycogen synthase kinase 3 beta	Rattus norvegicus	117-126
25193743-9	2014	Interestingly, inhibition of ROS with N-acetylcysteine abrogated Akt/Gsk-3beta activation and the LA-induced cytoprotection following SNP stimulation.	ros	29-32	glycogen synthase kinase 3 beta	Rattus norvegicus	69-78
25193743-10	2014	Taken together, the results indicate that LA protected the SNP-induced injury in cardiac H9c2 cells through, at least in part, the activation of Akt/Gsk-3beta signaling in a ROS-dependent mechanism.	ros	174-177	glycogen synthase kinase 3 beta	Rattus norvegicus	149-158
25520856-5	2014	The accumulated ROS induced DNA damage response (DDR), that mediated Chk1/Chk2 upregulation and activation which were essential factors for the G0/G1 arrest.	ros	16-19	checkpoint kinase 2	Mus musculus	74-78
25140997-13	2014	An Epac-1 agonist increased Epac-1 expression (P&lt;0.05) and the P-Akt (Ser473)/Akt ratio (P&lt;0.05) in a dose-dependent manner, and subsequently decreased apoptosis and intracellular ROS.	ros	186-189	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	3-9
25140997-14	2014	Conversely, Epac-1shRNA knocked-down Epac-1 expression (P&lt;0.01) and decreased the P-Akt (Ser473)/Akt ratio (P&lt;0.05), but had no effect on apoptosis and intracellular ROS levels.	ros	172-175	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	12-18
24929004-9	2014	The CD14(low) PMN-MDSC variant was demonstrated to suppress T cell proliferation in vitro via a ROS-dependent mechanism, to display an increased IL-10:TNF-alpha ratio, and to present with signs of immaturity: blast morphology and low cytokine levels.	ros	96-99	CD14 molecule	Homo sapiens	4-8
24933647-10	2014	P-p38 up-regulation induced by UA17/cisplatin combination through generation of ROS and Bcl-2 down-regulation induced by UA17/cisplatin combination increased cell death.	ros	80-83	mitogen-activated protein kinase 14	Mus musculus	2-5
26461418-3	2014	Selenoprotein methionine-R-sulfoxide reductase B1 (MsrB1) is a repair enzyme that reduces ROS-oxidized methionine residues in proteins.	ros	90-93	methionine sulfoxide reductase B1	Homo sapiens	51-56
24930757-10	2014	These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug.	ros	132-135	TNF receptor superfamily member 10a	Homo sapiens	180-183
25101674-0	2014	A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF).	ros	43-46	macrophage migration inhibitory factor	Homo sapiens	167-170
24754877-2	2014	Glabridin (GLA), which acts through the FAK/ROS signaling pathway, has been used as an antioxidant and anti-metastatic agent.	ros	44-47	protein tyrosine kinase 2	Homo sapiens	40-43
24906005-2	2014	CRIF1 is a protein present in the mitochondria associated with large mitoribosomal subunits, and CRIF1 knockdown induces mitochondrial dysfunction and promotes ROS production.	ros	160-163	GADD45G interacting protein 1	Homo sapiens	0-5
24906005-2	2014	CRIF1 is a protein present in the mitochondria associated with large mitoribosomal subunits, and CRIF1 knockdown induces mitochondrial dysfunction and promotes ROS production.	ros	160-163	GADD45G interacting protein 1	Homo sapiens	97-102
24906005-5	2014	Knockdown of CRIF1 decreased the expression of mitochondrial oxidative phosphorylation (OXPHOS) complexes I, III and IV, leading to increased mitochondrial ROS (mtROS) and hyperpolarization of the mitochondrial membrane potential.	ros	156-159	GADD45G interacting protein 1	Homo sapiens	13-18
24906005-6	2014	Knockdown of CRIF1 also stimulated phosphorylation of p66shc and increased cytosolic ROS in endothelial cells.	ros	85-88	GADD45G interacting protein 1	Homo sapiens	13-18
24906005-8	2014	However, p66shc knockdown blunted the alteration in mitochondrial dynamics and ROS production in CRIF1 knockdown endothelial cells.	ros	79-82	GADD45G interacting protein 1	Homo sapiens	97-102
24906005-10	2014	Taken together, these results suggest that CRIF1 knockdown partially induces endothelial activation via increased ROS production and phosphorylation of p66shc.	ros	114-117	GADD45G interacting protein 1	Homo sapiens	43-48
24727493-10	2014	In conclusion, ROS production and ET-1 are involved in ANG II-induced COX-2 expression in SHRs, explaining the greater COX-2 expression observed in this strain.	ros	15-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	70-75
24727493-10	2014	In conclusion, ROS production and ET-1 are involved in ANG II-induced COX-2 expression in SHRs, explaining the greater COX-2 expression observed in this strain.	ros	15-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	119-124
24727493-11	2014	Furthermore, pioglitazone inhibits ANG II-induced COX-2 expression likely by interfering with NF-kappaB and activator protein-1 proinflammatory pathways and downregulating ROS production and ET-1 transcription, thus contributing to the anti-inflammatory properties of glitazones.	ros	172-175	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	50-55
24872551-9	2014	OGD/reoxygenation-induced elevation of ROS, reduction of GSH, dysfunction of mitochondria, and activation of caspase-3 were rescued by overexpression of TIGAR or supplementation of NADPH, while knockdown of TIGAR aggravated these changes.	ros	39-42	2,4-dienoyl CoA reductase 1, mitochondrial	Mus musculus	181-186
24865768-10	2014	Moreover, ROS formation, the ratio of NADP+/NADPH and NADPH oxidase subunits expression of gp91phox and p47phox, lipid peroxidation level was significantly increased, while antioxidant enzyme SOD and GSH-Px activity were reduced in the myocardial tissue of diabetic mice.	ros	10-13	cytochrome b-245, beta polypeptide	Mus musculus	91-99
24885580-12	2014	CONCLUSIONS: These results suggest that visfatin induces MUC8 and MUC5B expression through p38 MAPK/ROS/NF-kappaB signaling pathway in human airway epithelial cells.	ros	100-103	nicotinamide phosphoribosyltransferase	Homo sapiens	40-48
24698731-7	2014	Additionally, the transmembrane receptor-like PTPs, RPTPmicro and RPTPalpha, as well as the cytoplasmic PTP1B, are highly expressed in ROS 17/2.8 cells.	ros	135-138	protein tyrosine phosphatase, receptor type, A	Rattus norvegicus	66-75
24810048-0	2014	Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.	ros	18-21	ataxia telangiectasia mutated	Mus musculus	50-53
24810048-0	2014	Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.	ros	18-21	yes-associated protein 1	Mus musculus	54-58
24810048-5	2014	Increased intracellular ROS induced (i) Yes-associated protein 1 (YAP1) expression independent of the canonical Hippo pathway as well as (ii) ATM and JNK activation.	ros	24-27	yes-associated protein 1	Mus musculus	40-64
24810048-5	2014	Increased intracellular ROS induced (i) Yes-associated protein 1 (YAP1) expression independent of the canonical Hippo pathway as well as (ii) ATM and JNK activation.	ros	24-27	yes-associated protein 1	Mus musculus	66-70
24810048-5	2014	Increased intracellular ROS induced (i) Yes-associated protein 1 (YAP1) expression independent of the canonical Hippo pathway as well as (ii) ATM and JNK activation.	ros	24-27	ataxia telangiectasia mutated	Mus musculus	142-145
24810048-11	2014	Our study highlights the coordinated control of glioma cell proliferation and metabolism by ROS through (i) ATM-YAP1-driven apoptotic pathway and (ii) JNK-regulated metabolic adaptation.	ros	92-95	ataxia telangiectasia mutated	Mus musculus	108-111
24810048-11	2014	Our study highlights the coordinated control of glioma cell proliferation and metabolism by ROS through (i) ATM-YAP1-driven apoptotic pathway and (ii) JNK-regulated metabolic adaptation.	ros	92-95	yes-associated protein 1	Mus musculus	112-116
24797518-2	2014	Numerous roles for Poldip2 have been proposed, including mitochondrial elongation, DNA replication/repair and ROS production via Nox4.	ros	110-113	polymerase (DNA-directed), delta interacting protein 2	Mus musculus	19-26
24797518-2	2014	Numerous roles for Poldip2 have been proposed, including mitochondrial elongation, DNA replication/repair and ROS production via Nox4.	ros	110-113	NADPH oxidase 4	Mus musculus	129-133
24486139-4	2014	The expression of SOD-2, but not of SOD-1, markedly increased after PA exposure, which also elevated the number of cells generating ROS.	ros	132-135	superoxide dismutase 2	Homo sapiens	18-23
24569874-0	2014	Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation.	ros	18-21	solute carrier family 2 member 4	Homo sapiens	89-94
24518283-7	2014	The OPG and RANKL mRNA from ROS 17/2.8 was detected by RT-PCR.	ros	28-31	TNF receptor superfamily member 11b	Homo sapiens	4-7
24357053-7	2014	Accordingly, in vitro studies showed that PI3Kgamma was required for EP-induced monocyte migration and ROS production and that this effect was dependent upon neuraminidase activity.	ros	103-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	42-51
24681637-11	2014	Conversely, downregulation of Keap1 decreased autophagy levels, increased Nrf2 activation, upregulated cytoprotective antioxidant gene expression, and caused accumulation of p62, suggesting a feedback loop between ROS-regulated Keap1-Nrf2 and Atg7-regulated autophagy.	ros	214-217	autophagy related 7	Homo sapiens	243-247
25053988-0	2014	Hexokinase II inhibitor, 3-BrPA induced autophagy by stimulating ROS formation in human breast cancer cells.	ros	65-68	hexokinase 2	Homo sapiens	0-13
24291162-3	2014	Exposure of SK-RC-45 cells with different concentrations of CdCl2 (e.g. 0, 10 and 20muM) in serum free medium for 24h generate considerable amount of ROS, accompanied with decreased cell viability and alternations in the cellular and nuclear morphologies, heat shock responses and GCLC mediated protective responses.	ros	150-153	glutamate-cysteine ligase catalytic subunit	Homo sapiens	281-285
24600403-2	2014	Recently, we discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (Nox2) dependent ROS generation (X-ROS).	ros	105-108	cytochrome b-245, beta polypeptide	Mus musculus	72-87
24600403-2	2014	Recently, we discovered a pathway by which mechanical stretch activates NADPH Oxidase 2 (Nox2) dependent ROS generation (X-ROS).	ros	105-108	cytochrome b-245, beta polypeptide	Mus musculus	89-93
24550737-7	2014	Here we report that the ros mutant mice harboring a recessive mutation in the Slc35d3 gene show obesity and MetS and reduced membrane dopamine receptor D1 (D1R) with impaired dopamine signaling in striatal neurons.	ros	24-27	solute carrier family 35, member D3	Mus musculus	78-85
24550737-7	2014	Here we report that the ros mutant mice harboring a recessive mutation in the Slc35d3 gene show obesity and MetS and reduced membrane dopamine receptor D1 (D1R) with impaired dopamine signaling in striatal neurons.	ros	24-27	dopamine receptor D1	Mus musculus	134-154
24550737-7	2014	Here we report that the ros mutant mice harboring a recessive mutation in the Slc35d3 gene show obesity and MetS and reduced membrane dopamine receptor D1 (D1R) with impaired dopamine signaling in striatal neurons.	ros	24-27	leiomodin 1	Homo sapiens	156-159
24096089-6	2014	The Park2-depleted beta-cells also exhibited increased mitochondrial fragmentation and ROS production and decreased mitochondrial membrane potential.	ros	87-90	parkin RBR E3 ubiquitin protein ligase	Rattus norvegicus	4-9
24211111-8	2014	In PMVECs, IL-1beta-mediated production of ROS and activation of redox-sensitive NF-kappaB were PKCdelta dependent, suggesting an upstream signaling role.	ros	43-46	protein kinase C delta	Homo sapiens	96-104
24259511-4	2014	Exogenous TGF-beta1-induced podocyte apoptosis through caspase-3 activation, which was related to elevated ROS levels generated by selective upregulation of NADPH oxidase 4 (Nox4).	ros	107-110	transforming growth factor, beta 1	Mus musculus	10-19
24259511-4	2014	Exogenous TGF-beta1-induced podocyte apoptosis through caspase-3 activation, which was related to elevated ROS levels generated by selective upregulation of NADPH oxidase 4 (Nox4).	ros	107-110	NADPH oxidase 4	Mus musculus	157-172
24259511-4	2014	Exogenous TGF-beta1-induced podocyte apoptosis through caspase-3 activation, which was related to elevated ROS levels generated by selective upregulation of NADPH oxidase 4 (Nox4).	ros	107-110	NADPH oxidase 4	Mus musculus	174-178
24259511-6	2014	TGF-beta1-induced ROS production and caspase activation were mitigated by an antioxidant, the Nox inhibitor diphenyleneiodonium, or small interfering RNA for Nox4.	ros	18-21	transforming growth factor, beta 1	Mus musculus	0-9
24259511-6	2014	TGF-beta1-induced ROS production and caspase activation were mitigated by an antioxidant, the Nox inhibitor diphenyleneiodonium, or small interfering RNA for Nox4.	ros	18-21	NADPH oxidase 4	Mus musculus	158-162
30368039-7	2019	SOD2 as a key enzyme can decrease mitochondrial ROS (mROS) level, Deacetylation of SOD2 by SIRT3 regulates SOD2 enzymatic activity has been identified.	ros	48-51	superoxide dismutase 2	Homo sapiens	0-4
24259511-8	2014	Knockdown of either Smad2 or Smad3 prevented the increase of Nox4 expression, ROS generation, loss of mitochondrial membrane potential, and caspase-3 activation by TGF-beta1.	ros	78-81	SMAD family member 3	Mus musculus	29-34
24259511-9	2014	These results suggest that TGF-beta1-induced mitochondrial Nox4 upregulation via the TGF-beta receptor-Smad2/3 pathway is responsible for ROS production, mitochondrial dysfunction, and apoptosis, which may at least in part contribute to the development and progression of proteinuric glomerular diseases such as diabetic nephropathy.	ros	138-141	transforming growth factor, beta 1	Mus musculus	27-36
24259511-9	2014	These results suggest that TGF-beta1-induced mitochondrial Nox4 upregulation via the TGF-beta receptor-Smad2/3 pathway is responsible for ROS production, mitochondrial dysfunction, and apoptosis, which may at least in part contribute to the development and progression of proteinuric glomerular diseases such as diabetic nephropathy.	ros	138-141	NADPH oxidase 4	Mus musculus	59-63
30368039-7	2019	SOD2 as a key enzyme can decrease mitochondrial ROS (mROS) level, Deacetylation of SOD2 by SIRT3 regulates SOD2 enzymatic activity has been identified.	ros	48-51	superoxide dismutase 2	Homo sapiens	83-87
25093162-10	2014	Taken together, these data not only provide the first in vivo evidence for a role of RIP3 in TNF-alpha-induced toxicity of hippocampal neurons, but also demonstrate that TNF-alpha promotes CYLD-RIP1-RIP3-MLKL-mediated necroptosis of hippocampal neurons largely bypassing ROS accumulation and calcium influx.	ros	271-274	CYLD lysine 63 deubiquitinase	Mus musculus	189-193
30368039-7	2019	SOD2 as a key enzyme can decrease mitochondrial ROS (mROS) level, Deacetylation of SOD2 by SIRT3 regulates SOD2 enzymatic activity has been identified.	ros	48-51	superoxide dismutase 2	Homo sapiens	83-87
30586869-7	2018	Interestingly, such combination treatments further increased intracellular ROS and cytotoxicity induced by the single TB or bortezomib treatment, suggesting that NRF2, HSF1 and p62/SQSTM1 keep the ROS level under control, allowing primary effusion lymphoma (PEL) cells to continue to survive and KSHV to replicate.	ros	197-200	heat shock transcription factor 1	Homo sapiens	168-172
30545412-0	2018	1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis.	ros	147-150	nuclear receptor subfamily 0 group B member 2	Homo sapiens	114-118
30372866-6	2018	The results showed that CAPE-pNO2 can alleviate CK, LDH, TC and TG levels, as well as depress the activity of ROS by down-regulating the expression of NOX4 and improving SOD activity in the serum of STZ-induced DCM mice.	ros	110-113	structural maintenance of chromosomes 2	Mus musculus	24-28
24189590-1	2014	Under condition of ROS formation in lipid membranes, free radical reactions can proceed in both hydrophobic (peroxidation of lipids, POL) and polar (free radical fragmentation) parts of the bilayer.	ros	19-22	endogenous retrovirus group W member 4	Homo sapiens	133-136
24384279-0	2014	Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo.	ros	88-91	caspase 3	Rattus norvegicus	101-110
27784668-8	2016	The conditioned media of the ROS 17/2.8 contained bone morphogenetic protein-2 (BMP-2 8.4 ng/mg, standard deviation (sd) 0.8) and BMP-7 (50.6 ng/mg, sd 2.2).	ros	29-32	bone morphogenetic protein 2	Rattus norvegicus	50-78
30372866-6	2018	The results showed that CAPE-pNO2 can alleviate CK, LDH, TC and TG levels, as well as depress the activity of ROS by down-regulating the expression of NOX4 and improving SOD activity in the serum of STZ-induced DCM mice.	ros	110-113	NADPH oxidase 4	Mus musculus	151-155
30596104-8	2018	More importantly, we for the first time found that PT was more effective than Pan in inducing ROS accumulation by suppression of the Nrf2-Keap1 antioxidant pathway, and then induced apoptosis in KYSE-450 esophageal cancer cells, which may partly explain the more sensitive response of KYSE-450 to PT treatment.	ros	94-97	adenosine deaminase 2	Homo sapiens	78-81
30343565-9	2018	These results indicate that Gln deficiency activates autophagy by upregulating ROS-medicated JAK2/STAT3 signaling and thereby promoting PCV2 infection.	ros	79-82	Janus kinase 2	Homo sapiens	93-97
25371776-4	2014	In this study, an increased PKCdelta and p66Shc activation and ROS production in renal tissues of patients with diabetic nephropathy were seen and further analysis revealed a positive correlation between the tubulointerstitial damage and p-PKCdelta, p-p66Shc, and ROS production.	ros	264-267	protein kinase C delta	Homo sapiens	28-36
25371776-7	2014	Moreover, PKCdelta siRNA partially blocked HG-induced p66Shc phosphorylation, translocation, and ROS production in HK-2 cells.	ros	97-100	protein kinase C delta	Homo sapiens	10-18
27679973-5	2016	Nur77 activation further decreased cell viability, aggravated intracellular LDH release, intracellular Ca2+, ROS levels, apoptosis, ER tress and, mitochondrial transmembrane potential (DeltaPsim) decline.	ros	109-112	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	0-5
27669008-9	2016	However ROS levels varied between AMLs; Flt3ITD+/NPM1wild-type CD34+SPC had higher ROS than NPM1mutated CD34+ or CD34- SPC.	ros	8-11	nucleophosmin 1	Homo sapiens	49-53
30267671-7	2018	Moreover, we determined that the physiological role of PPTC7 takes place in the adaptation to starvation and pro-oxidant conditions, facilitating the induction of mitochondrial metabolism while preventing the accumulation of ROS.	ros	225-228	protein phosphatase targeting COQ7	Homo sapiens	55-60
27669008-9	2016	However ROS levels varied between AMLs; Flt3ITD+/NPM1wild-type CD34+SPC had higher ROS than NPM1mutated CD34+ or CD34- SPC.	ros	83-86	nucleophosmin 1	Homo sapiens	49-53
24494188-4	2014	By overexpression and knockdown experiments, we showed that Nox1 on a post-translational level regulated the stability of CK18 in an ROS-, phosphorylation- and PKCepilon-dependent manner.	ros	133-136	NADPH oxidase 1	Homo sapiens	60-64
24367694-5	2013	None of the tested PLMs stimulate ROS production, indicating that caspase-1 activation may occur through a ROS-independent pathway.	ros	107-110	caspase 1	Mus musculus	66-75
30230261-9	2018	Phospho-ULK1 (p-ULK1) at these sites are all essential for PEDF-induced mitophagy and reduce the release of mitochondrial ROS and DNA.	ros	122-125	unc-51 like autophagy activating kinase 1	Homo sapiens	8-12
24268699-6	2013	Moreover, we found that ROS-induced autophagy acts as a negative feedback regulator of JNK activity by dissociating Atg9/mAtg9 from dTRAF2/TRAF6 in Drosophila and mammalian cells, respectively.	ros	24-27	TNF-receptor-associated factor 6	Drosophila melanogaster	132-138
24268699-6	2013	Moreover, we found that ROS-induced autophagy acts as a negative feedback regulator of JNK activity by dissociating Atg9/mAtg9 from dTRAF2/TRAF6 in Drosophila and mammalian cells, respectively.	ros	24-27	TNF-receptor-associated factor 6	Drosophila melanogaster	139-144
27899819-6	2016	Further investigation showed that 4-cholesten-3-one promoted ROS generation, which transiently activated AMPKalpha1, increased HIF1alpha expression, reduced Bcl-2 expression and caused autophagy.	ros	61-64	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	105-115
30230261-9	2018	Phospho-ULK1 (p-ULK1) at these sites are all essential for PEDF-induced mitophagy and reduce the release of mitochondrial ROS and DNA.	ros	122-125	unc-51 like autophagy activating kinase 1	Homo sapiens	16-20
27489105-4	2016	We found that deletion of both NOX1 and NOX2 led to a dramatic decrease in ROS production in macrophages and resulted in impaired efficiency in monocyte-to-macrophage differentiation and M2-type macrophage polarization.	ros	75-78	NADPH oxidase 1	Mus musculus	31-35
23770845-6	2013	We show that the mechanism by which GW9662 treatment causes a reduction in ALDH-positive population cells is partially due to ROS, as it can be rescued by treatment with N-acetyl-cysteine.	ros	126-129	aldehyde dehydrogenase family 3, subfamily A1	Mus musculus	75-79
30230261-9	2018	Phospho-ULK1 (p-ULK1) at these sites are all essential for PEDF-induced mitophagy and reduce the release of mitochondrial ROS and DNA.	ros	122-125	serpin family F member 1	Homo sapiens	59-63
27489105-4	2016	We found that deletion of both NOX1 and NOX2 led to a dramatic decrease in ROS production in macrophages and resulted in impaired efficiency in monocyte-to-macrophage differentiation and M2-type macrophage polarization.	ros	75-78	cytochrome b-245, beta polypeptide	Mus musculus	40-44
30190170-11	2018	A hypo-methylation of H3K4 at SOD2 promoter by LSD-1 increased ROS causing diabetic retinopathy.	ros	63-66	superoxide dismutase 2	Homo sapiens	30-34
27250720-6	2016	Furthermore, ERbeta inhibition prevented the effect of tibolone on nuclear fragmentation, ROS and mitochondrial membrane potential in GD cells.	ros	90-93	estrogen receptor 2	Homo sapiens	13-19
24121479-0	2013	A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signaling.	ros	93-96	ras homolog family member B	Homo sapiens	73-77
24121479-7	2013	Moreover, the p300 binding site and two CCAAT boxes in the RhoB promoter appear to be involved in ROS-mediated RhoB expression in the presence of KR28.	ros	98-101	ras homolog family member B	Homo sapiens	59-63
24121479-7	2013	Moreover, the p300 binding site and two CCAAT boxes in the RhoB promoter appear to be involved in ROS-mediated RhoB expression in the presence of KR28.	ros	98-101	ras homolog family member B	Homo sapiens	111-115
24121479-8	2013	CONCLUSION: The antitumor agent KR28 induces apoptosis of PC-3 cells by ROS-mediated RhoB expression via c-Abl upregulation and activation of p38 MAPK/ATF-2.	ros	72-75	ras homolog family member B	Homo sapiens	85-89
27618431-9	2016	We demonstrated that miR-223 overexpression promoted TRAIL-induced apoptosis through the mitochondria/ROS pathway.	ros	102-105	microRNA 223	Homo sapiens	21-28
29978911-7	2018	Protopheophorbide A inhibited HGF-induced downstream c-Met-dependent cell proliferation, survival, adhesion and migration through RAF/MEK/ERK and PI3K/PTEN/AKT signaling pathways modulation, ROS generation and activation of JNK and p38 pathways.	ros	191-194	hepatocyte growth factor	Homo sapiens	30-33
27416292-8	2016	Specially, lapatinib activated both the c-Myc/pro-Nrf2 pathway and GSK-3beta signaling to stabilize Nrf2 and maintain a low level of ROS in resistant cells.	ros	133-136	glycogen synthase kinase 3 beta	Homo sapiens	67-76
30352992-9	2018	Drugs blocking ROS production prevent GSDMD cleavage supporting a role of oxidative stress in GSDMD-mediated secretion.	ros	15-18	gasdermin D	Homo sapiens	38-43
23978445-0	2013	Ethanol increases matrix metalloproteinase-12 expression via NADPH oxidase-dependent ROS production in macrophages.	ros	85-88	matrix metallopeptidase 12	Mus musculus	18-45
27276443-6	2016	FGF21 also suppressed profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level, and restored the activities of antioxidant enzymes SOD and GSH-Px in LPS-stimulated RAW 264.7 macrophages.	ros	44-47	fibroblast growth factor 21	Mus musculus	0-5
30352992-9	2018	Drugs blocking ROS production prevent GSDMD cleavage supporting a role of oxidative stress in GSDMD-mediated secretion.	ros	15-18	gasdermin D	Homo sapiens	94-99
23978445-7	2013	Furthermore, knockdown of Nox2 by small interfering RNA (siRNA) prevented ethanol-induced ROS production and MMP-12 expression in RAW 264.7 macrophages, indicating a critical role for Nox2 in ethanol-induced intracellular ROS production and MMP-12 expression in macrophages.	ros	90-93	cytochrome b-245, beta polypeptide	Mus musculus	26-30
30425495-10	2018	The overexpression of miR-451 increased cell viability and SOD activity, but decreased apoptosis rate, levels of LDH, MDA, ROS and cleaved caspase-3 expression.	ros	123-126	microRNA 451a	Homo sapiens	22-29
23978445-7	2013	Furthermore, knockdown of Nox2 by small interfering RNA (siRNA) prevented ethanol-induced ROS production and MMP-12 expression in RAW 264.7 macrophages, indicating a critical role for Nox2 in ethanol-induced intracellular ROS production and MMP-12 expression in macrophages.	ros	222-225	cytochrome b-245, beta polypeptide	Mus musculus	26-30
23978445-7	2013	Furthermore, knockdown of Nox2 by small interfering RNA (siRNA) prevented ethanol-induced ROS production and MMP-12 expression in RAW 264.7 macrophages, indicating a critical role for Nox2 in ethanol-induced intracellular ROS production and MMP-12 expression in macrophages.	ros	222-225	matrix metallopeptidase 12	Mus musculus	109-115
23978445-7	2013	Furthermore, knockdown of Nox2 by small interfering RNA (siRNA) prevented ethanol-induced ROS production and MMP-12 expression in RAW 264.7 macrophages, indicating a critical role for Nox2 in ethanol-induced intracellular ROS production and MMP-12 expression in macrophages.	ros	222-225	cytochrome b-245, beta polypeptide	Mus musculus	184-188
23978445-7	2013	Furthermore, knockdown of Nox2 by small interfering RNA (siRNA) prevented ethanol-induced ROS production and MMP-12 expression in RAW 264.7 macrophages, indicating a critical role for Nox2 in ethanol-induced intracellular ROS production and MMP-12 expression in macrophages.	ros	222-225	matrix metallopeptidase 12	Mus musculus	241-247
23978445-10	2013	Taken together, these results demonstrate that ethanol treatment elicited increase in MMP-12 expression via increase in ROS production derived from Nox2 in macrophages.	ros	120-123	matrix metallopeptidase 12	Mus musculus	86-92
27151770-9	2016	Further, shRNA-mediated knockdown and genetic ablation of PKCdelta in primary microglia blunted the microglial proinflammatory response elicited by the inflammogens, including ROS generation, nitric oxide production, and proinflammatory cytokine and chemokine release.	ros	176-179	protein kinase C delta	Homo sapiens	58-66
23978445-10	2013	Taken together, these results demonstrate that ethanol treatment elicited increase in MMP-12 expression via increase in ROS production derived from Nox2 in macrophages.	ros	120-123	cytochrome b-245, beta polypeptide	Mus musculus	148-152
29935235-7	2018	Furthermore, PACAP induced ROS through H2O2 production whereas pretreatment with NAC inhibitor decreased AKT and ERK phosphorylation, but not p38.	ros	27-30	adenylate cyclase activating polypeptide 1	Homo sapiens	13-18
27378626-7	2016	Biochemical evidence of apoptosis came from elevating the intracellular ROS level that was accompanied by mitochondrial membrane potential loss, decreasing the expression profile of anti-apoptotic protein Bcl-2, whereas it augments cleavage of caspase-3 and PARP-1, activates caspase-8 and 9 with concomitant increase in expression of proapoptotic protein Bax in a dose dependent manner.	ros	72-75	caspase 8	Homo sapiens	276-285
24244496-5	2013	Overexpression experiments show that gain of Mpc2 function leads to a severe respiration defect and ROS accumulation, while Mpc3 stimulates respiration and enhances tolerance to oxidative stress.	ros	100-103	mitochondrial pyruvate carrier	Saccharomyces cerevisiae S288C	45-49
29935235-11	2018	In conclusion, we demonstrated that PACAP signaling in MCF-7 cells follows the Src/Raf/ERK and PI3K/AKT pathways and is VPAC1 dependent in a ROS dependent manner, whereas it follows PLC and PKA/cAMP pathways and is VPAC2 dependent through p38 MAP kinase activation involving calcium.	ros	141-144	adenylate cyclase activating polypeptide 1	Homo sapiens	36-41
30554581-7	2018	Conclusion silencing SOX9 gene expression enhances apoptosis of laryngeal squamous cell carcinoma cells induced by As2O3, which is related to increasing the intacellular ROS content and down-regulating the PI3K/AKT signaling pathway.	ros	170-173	SRY-box transcription factor 9	Homo sapiens	21-25
23891589-4	2013	The above results suggested that UVB induced PDCD4 inhibition, which may be mediated through ROS, especially endogenous H2O2 and p38 and ERKs phosphorylation.	ros	93-96	programmed cell death 4	Homo sapiens	45-50
30208515-4	2018	IGF-1 improved activation of Nrf2, and inhibited ROS generation and endoplasmic reticulum dilation in HaCaT.	ros	49-52	insulin-like growth factor 1	Mus musculus	0-5
24216508-2	2013	NADPH oxidase 4 (NOX4), a constitutively active enzymatic source of ROS, may contribute to the development of such disorders.	ros	68-71	NADPH oxidase 4	Homo sapiens	0-15
24216508-2	2013	NADPH oxidase 4 (NOX4), a constitutively active enzymatic source of ROS, may contribute to the development of such disorders.	ros	68-71	NADPH oxidase 4	Homo sapiens	17-21
30125721-6	2018	The mechanism studies indicated the mitochondrial localization of BODIPY3-PEG3 was able to generate ROS in mitochondria, which further result in mitochondrial dysfunction and photoinduced apoptosis via caspase-8 and caspase-3 pathway.	ros	100-103	caspase 8	Homo sapiens	202-211
23982491-8	2013	STC1 overexpression in vitro recapitulates the pathophysiology of AL-LC mediated cardiotoxicity, with increased ROS production, contractile dysfunction and cell death.	ros	112-115	stanniocalcin 1	Homo sapiens	0-4
29574012-5	2018	Besides, AA (1.925 mM) and GA (0.872 mM) exposure increased ROS level and decreased mitochondrial membrane potential, which led to a decrease in progesterone production, while C3G ranging from 10 to 50 muM reduced ROS immediately, and increased progesterone production after 24 h treatment.	ros	214-217	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	176-179
23757405-6	2013	Muscle UCP1 activity had divergent effects on mitochondrial ROS emission and glutathione levels compared with BAT.	ros	60-63	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	7-11
23757405-8	2013	Intriguingly, unlike in BAT mitochondria, leak through UCP1 in muscle controlled mitochondrial ROS emission.	ros	95-98	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	55-59
23757405-9	2013	Inhibition of UCP1 with GDP in muscle mitochondria increased ROS emission ~2.8-fold relative to WT muscle mitochondria.	ros	61-64	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	14-18
23757405-12	2013	Moreover, ectopic UCP1 expression in skeletal muscle can control mitochondrial ROS emission, while it apparently plays no such role in its endogenous tissue, brown fat.	ros	79-82	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	18-22
29574012-8	2018	It was concluded that C3G is effective in reducing AA- and GA-induced reproductive toxicity via inhibition of ROS generation, mitochondrial membrane depolarization and apoptosis, as well as activating steroidogenic enzymes.	ros	110-113	Rap guanine nucleotide exchange factor 1	Rattus norvegicus	22-25
29487387-5	2018	NRF1 and NRF2 decrease upon MALAT1 targeting was due to transcriptional activation of their negative regulator KEAP1, and resulted in reduced expression of anti-oxidant genes and increased ROS levels.	ros	189-192	nuclear respiratory factor 1	Homo sapiens	0-4
30102256-6	2018	Mechanistically, ROS produced in diabetes induced c-Src-dependent but VEGF-C-independent VEGFR3 phosphorylation, and upregulated epsins through the activation of transcription factor AP-1.	ros	17-20	jun proto-oncogene	Mus musculus	183-187
24900591-3	2013	It also prevented ROS-induced damage of cellular lipid membranes and maintained the mitochondrial membrane potential of FRDA lymphocytes.	ros	18-21	frataxin	Homo sapiens	120-124
30138353-5	2018	Curcumin treatment significantly induced spermine oxidase (SMOX) mRNA and activity, which results in the generation of hydrogen peroxide, a source of ROS.	ros	150-153	spermine oxidase	Homo sapiens	41-57
23647015-9	2013	KEY RESULTS: Quercetin and allopurinol significantly inhibited the TXNIP overexpression, activation of NLRP3 inflammasome, down-regulation of PPARalpha and up-regulation of sterol regulatory element binding protein-1c (SREBP-1c), SREBP-2, fatty acid synthase and liver X receptor alpha, as well as elevation of ROS and IL-1beta in diabetic rat liver.	ros	311-314	sterol regulatory element binding transcription factor 1	Rattus norvegicus	173-217
23333744-7	2013	The second phase operated under a prolonged HGF exposure, caused a suppression of the NADPH oxidase components, including NOX2, NOX4, p22 and p67, and was able to abrogate the TGFbeta-induced ROS production and improve cell viability.	ros	192-195	transforming growth factor, beta 1	Mus musculus	176-183
30138353-5	2018	Curcumin treatment significantly induced spermine oxidase (SMOX) mRNA and activity, which results in the generation of hydrogen peroxide, a source of ROS.	ros	150-153	spermine oxidase	Homo sapiens	59-63
30140002-7	2018	Inhibition of the Trx and Grx systems leads to insufficient reducing power to deoxyribonucleotide production for DNA replication and repair and peroxiredoxin for removal of ROS.	ros	173-176	glutaredoxin	Homo sapiens	26-29
23454196-9	2013	The pink1 morphants were found to have heart dysfunction, increased erythropoiesis, increased expression of vascular endothelial growth factors, and increased ROS.	ros	159-162	PTEN induced kinase 1	Danio rerio	4-9
23570668-5	2013	High glucose levels also increased the generation of ROS; inhibition of ROS activity by N-acetyl-l-cysteine attenuated the high glucose-induced increase in TRPC6 expression and Ca(2+) influx.	ros	53-56	transient receptor potential cation channel subfamily C member 6	Homo sapiens	156-161
23570668-5	2013	High glucose levels also increased the generation of ROS; inhibition of ROS activity by N-acetyl-l-cysteine attenuated the high glucose-induced increase in TRPC6 expression and Ca(2+) influx.	ros	72-75	transient receptor potential cation channel subfamily C member 6	Homo sapiens	156-161
29623489-12	2018	Subsequently, less Nox2 was associated with ROS downregulation, inhibiting Drp1 phosphorylated activation.	ros	44-47	cytochrome b-245, beta polypeptide	Mus musculus	19-23
23570668-7	2013	Taken together, these data suggest that high glucose levels induce ROS, thereby mediating TRPC6 expression and Ca(2+) influx.	ros	67-70	transient receptor potential cation channel subfamily C member 6	Homo sapiens	90-95
23640457-11	2013	Transfection with TIGAR mutant (i) decreased apoptosis and gammaH2AX foci formation (ii) decreased p53 (iii) elevated ROS and (iv) increased Akt/Erk activation in cells cotreated with NCS and TNFalpha.	ros	118-121	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	18-23
23431043-10	2013	These findings suggest the involvement of ROS, MAPKs, and RARbeta activation in lutein-driven MMP-9 expression and release.	ros	42-45	matrix metallopeptidase 9	Mus musculus	94-99
23478801-13	2013	Therefore, we propose that Ngb controls HCC development by linking oxygen/ROS signals to oncogenic Raf/mitogen-activated protein kinase (MAPK)/Erk signaling.	ros	74-77	zinc fingers and homeoboxes 2	Homo sapiens	99-102
23535216-6	2013	In addition, we detected the mRNA expression of ucp-2 and bcl-2, which are located at the mitochondrial inner membrane and related to reactive oxidative species (ROS) production.	ros	162-165	BCL2 apoptosis regulator a	Danio rerio	58-63
23499005-4	2013	Moreover, B55alpha is specifically induced upon glutamine deprivation in a ROS-dependent manner to activate p53 and promote cell survival.	ros	75-78	protein phosphatase 2 regulatory subunit Balpha	Homo sapiens	10-18
23376140-6	2013	Also, ROS from NADPH oxidase favors ERK1/2 activation that phosphorylates Stat3 in serine, resulting in a compensatory or adaptive survival response such as production of metallothionein-II in short Cd exposure times.	ros	6-9	mitogen-activated protein kinase 3	Mus musculus	36-42
23519121-0	2013	Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells.	ros	15-18	NADPH oxidase 4	Homo sapiens	0-4
23271700-1	2013	A point mutation in the mouse Ncf1(m1J) gene decreases production of ROS by the phagocytic NOX2 complex.	ros	69-72	cytochrome b-245, beta polypeptide	Mus musculus	91-95
22903504-8	2013	Notably, LPS-induced ROS generation can partly facilitate p38 MAPK/JNK/AKT activation to regulate GSK-3beta-mediated Mcl-1 stability, apoptosis, and neutrophilia.	ros	21-24	mitogen-activated protein kinase 14	Mus musculus	58-61
22903504-8	2013	Notably, LPS-induced ROS generation can partly facilitate p38 MAPK/JNK/AKT activation to regulate GSK-3beta-mediated Mcl-1 stability, apoptosis, and neutrophilia.	ros	21-24	myeloid cell leukemia sequence 1	Mus musculus	117-122
23509821-4	2013	The inhibitory effect on the proliferation of A549 cells of Ad5/F35-APE1 siRNA is more significant after combining with PDT, as indicated by a significant elevation of the intracellular ROS level and the expression of inflammatory factors (P &lt; 0.05).	ros	186-189	Alzheimer disease, familial, type 5	Homo sapiens	60-63
23509821-4	2013	The inhibitory effect on the proliferation of A549 cells of Ad5/F35-APE1 siRNA is more significant after combining with PDT, as indicated by a significant elevation of the intracellular ROS level and the expression of inflammatory factors (P &lt; 0.05).	ros	186-189	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	68-72
23085260-4	2013	In EC, HG induced CIKS mRNA and protein expression via DPI-inhibitable Nox4-dependent ROS generation.	ros	86-89	NADPH oxidase 4	Mus musculus	71-75
23577160-2	2013	Evidence indicates that the Nox2-containing NADPH oxidase enzyme promotes influenza A virus-induced lung oxidative stress, inflammation and dysfunction via ROS generation.	ros	156-159	cytochrome b-245, beta polypeptide	Mus musculus	28-32
23577160-6	2013	HkX-31 virus infection of Nox1(-/y) mice resulted in significantly greater: loss of bodyweight (Day 3); BALF neutrophilia, peri-bronchial, peri-vascular and alveolar inflammation; Nox2-dependent inflammatory cell ROS production and peri-bronchial, epithelial and endothelial oxidative stress.	ros	213-216	NADPH oxidase 1	Mus musculus	26-30
23516464-8	2013	We showed that PRR-mediated angiotensin II-independent ROS formation is associated with activation of the MAPK/ERK1/2 and PI3/Akt signaling pathways and up-regulation of mRNA level of NOX 2 and NOX4 isoforms in neuronal cells.	ros	55-58	NADPH oxidase 4	Homo sapiens	194-198
23457492-5	2013	Moreover, VCP knockdown decreased intracellular ROS levels in normal and H2O2-treated cells, and an oxidation-resistant VCP impaired the ROS-induced cytoplasmic redistribution of catalase.	ros	48-51	valosin containing protein	Homo sapiens	10-13
23457492-5	2013	Moreover, VCP knockdown decreased intracellular ROS levels in normal and H2O2-treated cells, and an oxidation-resistant VCP impaired the ROS-induced cytoplasmic redistribution of catalase.	ros	137-140	valosin containing protein	Homo sapiens	120-123
23383302-3	2013	However the redox modulation of the migratory process in macrophages and in particular that from the NADPH oxidase-2 (Nox2) dependent ROS has not been established.	ros	134-137	cytochrome b-245, beta polypeptide	Mus musculus	101-116
23383302-3	2013	However the redox modulation of the migratory process in macrophages and in particular that from the NADPH oxidase-2 (Nox2) dependent ROS has not been established.	ros	134-137	cytochrome b-245, beta polypeptide	Mus musculus	118-122
22910858-10	2012	Ru360, an MCU blocker, provides protective effects by preventing ROS production and mitochondrial depolarization as well as attenuating mitochondrial swelling caused by Fe(2+) overload.	ros	65-68	mitochondrial calcium uniporter	Mus musculus	10-13
23000094-2	2012	We used CoCl(2) to mimic hypoxic conditions in cardiac H9c2 cells in order to study the mechanism by which ghrelin protects cardiac myocytes against hypoxic injury by regulating the content of intracellular ROS and autophagy levels.	ros	207-210	ghrelin and obestatin prepropeptide	Rattus norvegicus	107-114
23000094-8	2012	Ghrelin treatment significantly attenuated CoCl(2)-induced hypoxic injury by decreasing cell apoptosis, LDH activity, ROS content, and Nox1 expression and increasing cell viability, autophagy levels, catalase, and Mn-SOD mRNA levels and activities.	ros	118-121	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
23520763-0	2012	[NADPH oxidation-reduction reaction platform and its regulatory role in Ang II-mediated ROS signaling pathway].	ros	88-91	angiogenin	Homo sapiens	72-75
22951908-3	2012	The most important reactive oxygen/nitrogen species (ROS/RNS) detoxification mechanisms include superoxide dismutase (SOD), catalase, and glutathione peroxidase (GPx).	ros	53-56	superoxide dismutase 2	Homo sapiens	118-121
23111743-11	2012	CONCLUSIONS: The presented results suggest that antiapoptotic activity of cC results from its inhibitory effect on ROS production.	ros	115-118	cystatin C	Homo sapiens	74-76
22995623-6	2012	Further, the efficiency of one of the active molecules, ABN 10, was demonstrated by its intracellular ROS inhibition activity on RAW 264.7 macrophage cells by FACS analysis in dose-dependent manner.	ros	102-105	acyl-CoA synthetase long-chain family member 1	Mus musculus	159-163
22822009-1	2012	Flavocytochrome b(558), the catalytic core of the phagocyte NADPH oxidase (NOX2), mediates electron transfer from NADPH to molecular oxygen to generate superoxide, the precursor of highly ROS for host defense.	ros	188-191	cytochrome b-245, beta polypeptide	Mus musculus	75-79
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	ros	4-7	E1A binding protein p300	Homo sapiens	134-138
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	ros	4-7	E1A binding protein p300	Homo sapiens	173-177
22684029-10	2012	CONCLUSION: The shift of HIF-1 transactivation by ROS is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.	ros	50-53	E1A binding protein p300	Homo sapiens	163-167
22684029-10	2012	CONCLUSION: The shift of HIF-1 transactivation by ROS is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.	ros	50-53	E1A binding protein p300	Homo sapiens	218-222
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	0-3	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	112-118
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	0-3	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	112-118
22739161-8	2012	It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway.	ros	102-105	caspase 8	Homo sapiens	71-79
22508836-5	2012	These cellular responses delay apoptotic cell death by inducing the IRE1alpha-XBP-1 pathway in conjunction with ROS-mediated mTOR inhibition.	ros	112-115	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	68-77
22095288-0	2012	PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk.	ros	39-42	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	19-24
22288910-5	2012	This 2-ABP-induced COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI.	ros	54-57	amine oxidase copper containing 1	Homo sapiens	7-10
22288910-12	2012	Taken together, these results demonstrate that 2-ABP induces the carcinogenic factor COX-2 and that this induction is mediated through NADPH oxidase-derived ROS-dependent JNK/ERK-AP-1 pathways.	ros	157-160	amine oxidase copper containing 1	Homo sapiens	49-52
22273977-4	2012	We found that overexpression of AhR in the CL1-5 cell line reduced CSSP-induced ROS production and oxidative DNA damage, whereas knockdown of AhR expression increased ROS level in CSSP-exposed H1355 cells.	ros	80-83	aryl hydrocarbon receptor	Homo sapiens	32-35
22273977-4	2012	We found that overexpression of AhR in the CL1-5 cell line reduced CSSP-induced ROS production and oxidative DNA damage, whereas knockdown of AhR expression increased ROS level in CSSP-exposed H1355 cells.	ros	167-170	aryl hydrocarbon receptor	Homo sapiens	142-145
22120492-10	2012	These data suggest that C3G exerts its antiproliferative effect on TNF-alpha-induced VSMCs proliferation through inhibiting STAT3 activation by attenuating NoxA1-derived ROS over production.	ros	170-173	NADPH oxidase activator 1	Mus musculus	156-161
22140047-0	2012	Activation of endothelial TRPV4 channels mediates flow-induced dilation in human coronary arterioles: role of Ca2+ entry and mitochondrial ROS signaling.	ros	139-142	transient receptor potential cation channel subfamily V member 4	Homo sapiens	26-31
22140047-3	2012	Here, we examined the role of the transient receptor potential vanilloid type 4 (TRPV4) channel, a mechanosensitive Ca(2+)-permeable cation channel, in mediating ROS formation and flow-induced dilation in HCAs.	ros	162-165	transient receptor potential cation channel subfamily V member 4	Homo sapiens	34-79
22140047-3	2012	Here, we examined the role of the transient receptor potential vanilloid type 4 (TRPV4) channel, a mechanosensitive Ca(2+)-permeable cation channel, in mediating ROS formation and flow-induced dilation in HCAs.	ros	162-165	transient receptor potential cation channel subfamily V member 4	Homo sapiens	81-86
27538372-5	2016	Among the differentially expressed genes, Pdp1 expression was significantly decreased (27-fold) on D8 compared to D0, which was accompanied by suppressed mitochondrial indices, including ATP levels, membrane potential, ROS and mitochondrial Ca(2+).	ros	219-222	pyruvate dehydrogenase phosphatase catalytic subunit 1	Mus musculus	42-46
27529477-10	2016	We conclude that 1) normal cardiac performance requires basal NOS-1 activity and S-nitrosylation of the calcium-cycling machinery; 2) beta-adrenergic stimulation induces rapid and reversible NOS-1 dependent, PKA and ROS-dependent, S-nitrosylation of RyR2 and other proteins, accounting for about one third of its inotropic effect.	ros	216-219	ryanodine receptor 2	Rattus norvegicus	250-254
27334614-7	2016	Interestingly, aging-induced Mfn2 deficiency triggers a ROS-dependent adaptive signaling pathway through induction of HIF1alpha transcription factor and BNIP3.	ros	56-59	BCL2/adenovirus E1B interacting protein 3	Mus musculus	153-158
27166596-0	2016	Corrigendum to "Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1-AMPK-mTOR pathway" [Atherosclerosis 243 (1) (2015) 223-235].	ros	68-71	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	94-98
27109893-8	2016	The PGT combination induced apoptosis in HeLa cells by generation of ROS, decrease in ATP production even with around 1.89-fold increase in glucose consumption, cell cycle arrest at S-phase and substantial increase in sub-diploid (Sub-D) population.	ros	69-72	solute carrier organic anion transporter family member 2A1	Homo sapiens	4-7
27402482-4	2016	Inhibition of Nox4 activity by plumbagin blocks F-828-dependent ROS elevation.	ros	64-67	NADPH oxidase 4	Homo sapiens	14-18
27177084-5	2016	Knockdown of Bmi1 enhanced ROS production and promoted the cytotoxic effect of gemcitabine.	ros	27-30	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	13-17
26912410-8	2016	PAK2-inhibition protected acini from CCK-induced ROS-generation; caspase/trypsin-activation, important in early pancreatitis; as well as from cell-necrosis.	ros	49-52	p21 (RAC1) activated kinase 2	Rattus norvegicus	0-4
26952810-3	2016	Further investigation evidenced that MIF induced ROS generation.	ros	49-52	macrophage migration inhibitory factor	Homo sapiens	37-40
26952810-4	2016	MIF-induced ROS led to ERK phosphorylation, which facilitated HMGB1 release from the nucleus to the cytoplasm.	ros	12-15	macrophage migration inhibitory factor	Homo sapiens	0-3
26952810-4	2016	MIF-induced ROS led to ERK phosphorylation, which facilitated HMGB1 release from the nucleus to the cytoplasm.	ros	12-15	high mobility group box 1	Homo sapiens	62-67
27303747-9	2016	In the presence of PI4KA inhibitors, the mutants no longer induced PI4P, OSBP, or cholesterol accumulation at ROs, which aggregated into large cytoplasmic clusters.	ros	110-113	phosphatidylinositol 4-kinase alpha	Homo sapiens	19-24
26445208-11	2016	These results indicate that Ang-II induces CF proliferation and migration in part via Nox4/ROS-dependent IL-18 induction and MMP9 activation, and may involve AT1/Nox4 physical association.	ros	91-94	NADPH oxidase 4	Mus musculus	86-90
26445208-11	2016	These results indicate that Ang-II induces CF proliferation and migration in part via Nox4/ROS-dependent IL-18 induction and MMP9 activation, and may involve AT1/Nox4 physical association.	ros	91-94	interleukin 18	Mus musculus	105-110
26949104-8	2016	The effects of 1,25(OH)2D3 on GSH, ROS, and monocyte-endothelial adhesion were prevented in GCLC knockdown HUVEC.	ros	35-38	glutamate-cysteine ligase catalytic subunit	Homo sapiens	92-96
26874430-11	2016	Inhibition of ceramide synthesis with FB1 and ROS production with n-MPG scavenging rescued MMP activity and IL-1beta production in palmitate treated heterophils, but exacerbated monocyte suppression.	ros	46-49	matrix metallopeptidase 2	Gallus gallus	91-94
26905073-2	2016	ROS can activate matrix metalloproteinases (MMP), damage DNA and RNA.	ros	0-3	matrix metallopeptidase 2	Homo sapiens	44-47
27065868-12	2016	In the S1P-treated mice, we found that the levels of ICAM-1 protein and mRNA in the lung fractions, the pulmonary hematoma and leukocyte count in bronchoalveolar lavage fluid were enhanced through a PKCdelta/PYK2/NADPH oxidase/ROS/NF-kappaB signaling pathway.	ros	227-230	intercellular adhesion molecule 1	Mus musculus	53-59
26919094-5	2016	In this study, we demonstrate that B19 directly inhibits TrxR1 enzyme activity to elevate oxidative stress and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis in human gastric cancer cells.	ros	123-126	eva-1 homolog C	Homo sapiens	35-38
26919094-7	2016	Blockage of ROS production totally reversed B19-induced anti-cancer actions.	ros	12-15	eva-1 homolog C	Homo sapiens	44-47
26869514-4	2016	Here we report that TfR1 supports mitochondrial respiration and ROS production in human pancreatic ductal adenocarcinoma (PDAC) cells, which is required for their tumorigenic growth.	ros	64-67	transferrin receptor	Homo sapiens	20-24
26869514-5	2016	Elevated TfR1 expression in PDAC cells contributes to oxidative phosphorylation, which allows for the generation of ROS.	ros	116-119	transferrin receptor	Homo sapiens	9-13
26869514-9	2016	Together, our findings reveal that TfR1 can contribute to the mitochondrial respiration and ROS production, which have essential roles in growth and survival of pancreatic cancer.	ros	92-95	transferrin receptor	Homo sapiens	35-39
22140047-11	2012	TRPV4-mediated Ca(2+) entry may be an important signaling event leading to the flow-induced release of mitochondrial ROS in HCAs.	ros	117-120	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
22140047-12	2012	Elucidation of this novel TRPV4-ROS pathway may improve our understanding of the pathogenesis of coronary artery disease and/or other cardiovascular disorders.	ros	32-35	transient receptor potential cation channel subfamily V member 4	Homo sapiens	26-31
22095949-4	2012	Persistent activation of the Ang II receptor stimulated ROS-dependent phosphorylation of Src, leading to sustained EGFR-dependent signaling for TGFbeta expression.	ros	56-59	transforming growth factor, beta 1	Mus musculus	144-151
22239975-9	2012	Together, these data indicate there is a mechanism in human PBMCs where TLR4 activation by LPS leads to ROS generation through NOX4 and activation of the PI3K pathway.	ros	104-107	NADPH oxidase 4	Homo sapiens	127-131
30078736-7	2018	The effect of inhibition of ULK1 was measured by detecting the apoptotic rate, autophagy, and the ratio of ROS and NADPH.	ros	107-110	unc-51 like autophagy activating kinase 1	Homo sapiens	28-32
22613992-10	2012	Inhibition of PAR-2 activation reduced tryptase-induced TNF-alpha, IL-6 and ROS production, and mitochondrial membrane potential loss in microglia.	ros	76-79	F2R like trypsin receptor 1	Homo sapiens	14-19
26454147-6	2016	Mitochondrial ETC complex inhibitor MPP, TTFA, and myxothiazol significantly reduced [Ca(2+) ]i [ROS]i and PA tension (P &lt; 0.01), whereas antimycin A and NaN(3) did not effectively reduce them.	ros	97-100	M-phase phosphoprotein 6	Homo sapiens	36-39
29703842-10	2018	At the molecular level, we find that inhibition of USP14 rapidly triggers accumulation of poly-ubiquitinated proteins and chaperones, mitochondrial dysfunction, ER stress, and a ROS production leading to a caspase-independent cell death.	ros	178-181	ubiquitin specific peptidase 14	Homo sapiens	51-56
26810982-10	2016	Exogenous applied salicylic acid (SA) or hydrogen peroxide (H2O2) induced the expression of both genes, and H2O2 had a higher accumulation at the Bgt penetration sites in RLK over-expression transgenic plants, suggesting a possible involvement of SA and altered ROS homeostasis in the defense response to Bgt infection.	ros	262-265	F-box protein At5g07610	Triticum aestivum	171-174
27753033-6	2016	Signal transduction through these receptors activates NOX4 as the main source of ROS production in HUVECs.	ros	81-84	NADPH oxidase 4	Homo sapiens	54-58
22032839-7	2012	Moreover, CsA stimulated the extracellular secretion of CypB and induced ROS generation, leading to expressions of ER stress markers.	ros	73-76	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	10-13
21984036-10	2012	Our results show that PMA can induce MUC5AC expression by activation of the Duox1-ROS-TACE-TGF-alpha-EGFR signaling pathway.	ros	82-85	dual oxidase 1	Homo sapiens	76-81
21984036-10	2012	Our results show that PMA can induce MUC5AC expression by activation of the Duox1-ROS-TACE-TGF-alpha-EGFR signaling pathway.	ros	82-85	transforming growth factor alpha	Homo sapiens	91-100
29230937-5	2018	Additionally, the transgenic plants reduced H2 O2 and O2 - accumulation under salinity, which could be due to up-regulation of ROS scavenger activities such as SOD, APX and CAT as well as CmHSP70, CmHSP90.	ros	127-130	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	165-168
23029600-5	2012	The mitochondrial uncoupling protein UCP2, even though its uncoupling properties are debated, has been associated with protective functions against ROS toxicity.	ros	148-151	uncoupling protein 2	Homo sapiens	37-41
22693564-7	2012	Furthermore, baseline superoxide generation is higher in freshly-isolated adult UCP3(-/-) mouse cardiomyocytes compared to WT, suggesting an important role for UCP3 in regulating cardiomyocyte ROS under physiologic conditions.	ros	193-196	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	160-164
22693564-9	2012	CONCLUSION: STC1 activates a novel anti-oxidant pathway in cardiac myocytes through induction of UCP3, and may play an important role in suppressing ROS in the heart under normal physiologic conditions and ameliorate the deleterious effects of Ang II-mediated cardiac injury.	ros	149-152	stanniocalcin 1	Homo sapiens	12-16
26759708-11	2016	Moreover, TCS at this concentration augmented the ROS generation in treated NSC and depleted the glutathione activity.	ros	50-53	treacle ribosome biogenesis factor 1	Homo sapiens	10-13
22276192-9	2012	Expression of mutant huntingtin in primary neurons induced superoxide/ROS, an effect that was significantly reduced by constitutively active PPARgamma.	ros	70-73	huntingtin	Homo sapiens	21-31
30046372-0	2018	Activating the PGC-1alpha/TERT Pathway by Catalpol Ameliorates Atherosclerosis via Modulating ROS Production, DNA Damage, and Telomere Function: Implications on Mitochondria and Telomere Link.	ros	94-97	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	15-25
22115550-1	2011	Uncoupling protein 3 (UCP3) may reduce mitochondrial ROS production, and thereby protect against mitochondrial dysfunction in skeletal muscle.	ros	53-56	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	0-20
26759708-12	2016	Taken together, these results suggest that TCS can induce neurodegenerative effects in developing rat brains through mechanisms involving ROS activation and apoptosis initiation.	ros	138-141	treacle ribosome biogenesis factor 1	Homo sapiens	43-46
29861135-8	2018	The prf3 Arabidopsis plants show higher sensitivity to the bacterial flagellum peptide in both the plant growth and ROS responses.	ros	116-119	profilin	Arabidopsis thaliana	4-8
26963898-11	2016	These results indicated NOX2 may be involved in RyR2-induced ROS generation which mediated contusion-induced spinal cord injury.	ros	61-64	ryanodine receptor 2	Rattus norvegicus	48-52
22115550-1	2011	Uncoupling protein 3 (UCP3) may reduce mitochondrial ROS production, and thereby protect against mitochondrial dysfunction in skeletal muscle.	ros	53-56	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	22-26
22115550-3	2011	Here we show that UCP3 knockout mice indeed have elevated mitochondrial ROS production after short-term (8 weeks) high-fat feeding.	ros	72-75	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	18-22
22099309-7	2011	Starvation of mice where PGC-1alpha expression is abrogated results in loss of p53-mediated ROS clearance, enhanced p53-dependent apoptosis, and consequent severe liver atrophy.	ros	92-95	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	25-35
29669207-0	2018	ROS-Inducing Micelles Sensitize Tumor-Associated Macrophages to TLR3 Stimulation for Potent Immunotherapy.	ros	0-3	toll like receptor 3	Homo sapiens	64-68
27336467-0	2016	Inhibition of CPU0213, a Dual Endothelin Receptor Antagonist, on Apoptosis via Nox4-Dependent ROS in HK-2 Cells.	ros	94-97	NADPH oxidase 4	Homo sapiens	79-83
29669207-4	2018	Poly I:C (PIC, a TLR3 agonist)-loaded ZnPP PM (ZnPP PM/PIC) efficiently repolarized TAMs to M1 macrophages, which were reliant on ROS generation.	ros	130-133	toll like receptor 3	Homo sapiens	17-21
29626473-4	2018	High glucose decreased the protein expression of SOD2 and catalase, while the level of intracellular ROS and the apoptosis - related protein increased in TM3 cells.	ros	101-104	tropomyosin 1, alpha	Mus musculus	154-157
26350264-8	2016	Further analysis revealed novel mechanisms of ROS-induced CXCR4/SDF-1 signaling that stimulate autophagy formation in MCL cells for their survival.	ros	46-49	C-X-C motif chemokine ligand 12	Homo sapiens	64-69
21696891-7	2011	Although burn decreased the number of CD68(+) Kupffer cells with phagocytic activity, IL-18 treatment partially restored their proportion, and augmented phagocytosis-induced ROS production in CD68(+) Kupffer cells after the injection of heat-killed Escherichia coli.	ros	174-177	interleukin 18	Mus musculus	86-91
21696891-7	2011	Although burn decreased the number of CD68(+) Kupffer cells with phagocytic activity, IL-18 treatment partially restored their proportion, and augmented phagocytosis-induced ROS production in CD68(+) Kupffer cells after the injection of heat-killed Escherichia coli.	ros	174-177	CD68 antigen	Mus musculus	192-196
26850078-8	2016	CONCLUSION: MPT induced by MF exposure was mediated through the ROS/GSK-3beta signaling pathway.	ros	64-67	glycogen synthase kinase 3 beta	Homo sapiens	68-77
29626473-6	2018	In conclusion, our data suggest that GAPDS overexpression antagonize high glucose-induced apoptosis by controlling ROS accumulation in TM3 cells.	ros	115-118	tropomyosin 1, alpha	Mus musculus	135-138
21946064-4	2011	aterf71/hre2 loss-of-function mutants displayed higher sensitivity to osmotic stress such as high salt and mannitol, accumulating higher levels of ROS under high salt treatment.	ros	147-150	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	8-12
21946064-5	2011	In contrast, AtERF71/HRE2-overexpressing transgenic plants showed tolerance to salt and mannitol as well as flooding and MV stresses, exhibiting lower levels of ROS under high salt treatment.	ros	161-164	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	13-20
27746591-6	2016	Monocytes obtained from TSC1 KO mice produced more ROS, IL-6, IL-10, and TGF-beta and less IL-1, IFN-gamma, and TNF-alpha.	ros	51-54	TSC complex subunit 1	Mus musculus	24-28
29542272-3	2018	METHODS: ROS formation by Calu-3 human airway cells was studied by measuring dihydrorhodamine 123 oxidation after activation by polyinosinic:polycytidylic acid (to activate TLR3), CL097 (to activate TLR7), a natural mixture of HDM allergens, or BzATP.	ros	9-12	toll like receptor 3	Homo sapiens	173-177
27547294-9	2016	In addition, we demonstrated that the increase of FOXO1 nuclear translocation was associated with the increased expressions of antioxidant catalase and SOD2 and the attenuated expression of the ROS generation enzyme NOX4.	ros	194-197	forkhead box O1	Rattus norvegicus	50-55
21946064-5	2011	In contrast, AtERF71/HRE2-overexpressing transgenic plants showed tolerance to salt and mannitol as well as flooding and MV stresses, exhibiting lower levels of ROS under high salt treatment.	ros	161-164	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	21-25
29614432-9	2018	Treatment of HAVICs with Lp(a) significantly increased ROS formation (p&lt;0.05).	ros	55-58	lipoprotein(a)	Homo sapiens	25-30
21856739-1	2011	Oxidation of the catalytic cysteine of protein-tyrosine phosphatases (PTP), which leads to their reversible inactivation, has emerged as an important regulatory mechanism linking cellular tyrosine phosphorylation and signalling by reactive-oxygen or -nitrogen species (ROS, RNS).	ros	269-272	protein tyrosine phosphatase receptor type U	Homo sapiens	39-68
21856739-1	2011	Oxidation of the catalytic cysteine of protein-tyrosine phosphatases (PTP), which leads to their reversible inactivation, has emerged as an important regulatory mechanism linking cellular tyrosine phosphorylation and signalling by reactive-oxygen or -nitrogen species (ROS, RNS).	ros	269-272	protein tyrosine phosphatase receptor type U	Homo sapiens	70-73
27594970-8	2016	Through our research efforts, we discovered that two genes encoding mitochondrial proteins, one (Ndufc2) involved in OXPHOS complex I assembly and activity and the second one (UCP2) involved in clearance of mitochondrial ROS, are responsible, when dysregulated, for vascular damage in SHRSP.	ros	221-224	uncoupling protein 2	Homo sapiens	176-180
28042384-8	2016	Our results suggest that APN peptide increased cell viability, SOD, and GSH-Px levels and decreased LDH release, ROS and MDA levels, and cell apoptosis.	ros	113-116	alanyl aminopeptidase, membrane	Homo sapiens	25-28
29275510-7	2018	Our data suggest that 100 muM BPA increased CYP1B1 and HSD17B14 gene and protein expression and release of endogenous estradiol, which was associated with increased ROS production and DNA double-strand breaks, upregulation of genes and/or proteins in steroid synthesis and metabolism, and activation of Nrf2-regulated stress response pathways.	ros	165-168	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	44-50
22057485-5	2011	The levels of ROS/NO in B78-H1 melanoma cells treated with pheophorbide a (Pba) and light (Pba/PDT) were measured by FACS, while expression of NF-kappaB, Snail and RKIP were determined by Western blots.	ros	14-17	acyl-CoA synthetase long-chain family member 1	Mus musculus	117-121
29435014-0	2018	Mitochondrial ROS contribute to oridonin-induced HepG2 apoptosis through PARP activation.	ros	14-17	collagen type XI alpha 2 chain	Homo sapiens	73-77
21494253-6	2011	Additionally, ROS inhibition reduced AMD3100-induced SDF-1 release, activation of circulating uPA and mobilization of progenitor cells.	ros	14-17	chemokine (C-X-C motif) ligand 12	Mus musculus	53-58
29448104-12	2018	The expression of AIM2 can be inhibited when the ROS inhibitor was used.	ros	49-52	absent in melanoma 2	Mus musculus	18-22
21486680-0	2011	The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis.	ros	80-83	mitogen activated protein kinase 14	Rattus norvegicus	98-101
26388407-0	2015	Esculetin induces apoptosis in human gastric cancer cells through a cyclophilin D-mediated mitochondrial permeability transition pore associated with ROS.	ros	150-153	peptidylprolyl isomerase D	Homo sapiens	68-81
26359457-10	2015	Second, Sod2 alters the steady-state ROS balance to drive H2O2-mediated migration.	ros	37-40	superoxide dismutase 2	Homo sapiens	8-12
29404777-0	2018	Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway.	ros	74-77	mitogen-activated protein kinase 14	Mus musculus	78-86
26563741-5	2015	BRAP exerted potent antioxidant and anti-inflammatory activity in lipopolysaccharide (LPS)- and H2O2-stimulated cells by suppressing the generation of ROS and pro-inflammatory cytokines.	ros	151-154	BRCA1 associated protein	Mus musculus	0-4
21411092-7	2011	CONCLUSIONS: Nox1-derived ROS modify lesion composition and contribute to lesion size in a murine model of atherosclerosis.	ros	26-29	NADPH oxidase 1	Mus musculus	13-17
29024600-0	2018	Liver X receptor alpha is targeted by microRNA-1 to inhibit cardiomyocyte apoptosis through a ROS-mediated mitochondrial pathway.	ros	94-97	microRNA 1	Rattus norvegicus	38-48
26085341-5	2015	In order to solve the problems during transplantation therapy, such as the need for an enormous amount of PSCs and good cell survival in overactive autoimmunity induced by reactive oxygen cpecies (ROS) in D1M patients, we utilized Wnt3a overexpression to activate the canonical Wnt signaling pathway in PSCs.	ros	197-200	Wnt family member 3A	Homo sapiens	231-236
29024245-5	2018	Importantly, this phenotype appears to be directly related to Nox enzyme-dependent ROS production, as both genetic inhibition by nox1 and nox2 morpholinos or pharmacologic rescue using ROS scavenging agents restores normal cardiac structure.	ros	83-86	cytochrome b-245, beta polypeptide (chronic granulomatous disease)	Danio rerio	138-142
26085341-5	2015	In order to solve the problems during transplantation therapy, such as the need for an enormous amount of PSCs and good cell survival in overactive autoimmunity induced by reactive oxygen cpecies (ROS) in D1M patients, we utilized Wnt3a overexpression to activate the canonical Wnt signaling pathway in PSCs.	ros	197-200	Wnt family member 3A	Homo sapiens	231-234
26085341-7	2015	We also showed that activation of the Wnt pathway made cells more readily tolerate ROS-caused mitochondria injury and cell apoptosis, thus making cells survive in autoimmune patients.	ros	83-86	Wnt family member 3A	Homo sapiens	38-41
21399877-7	2011	In addition, each caspase inhibitor and siRNA differently affects ROS levels including O2 - regardless of cell growth inhibition and cell death levels.	ros	66-69	caspase 8	Homo sapiens	18-25
29143862-10	2018	A20 ameliorates HFD-induced lipid accumulation, ROS, inflammation, apoptosis, hypertrophy, fibrosis, and cardiac dysfunction.	ros	48-51	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
21539811-7	2011	In addition, an increase in the intracellular levels of ROS in response to DOX was also inhibited in cells overexpressing Nek6.	ros	56-59	NIMA related kinase 6	Homo sapiens	122-126
21276840-4	2011	IL-11 (20 ng/ml) increased BSP mRNA and protein levels at 12h in osteoblast-like ROS 17/2.8 cells.	ros	81-84	interleukin 11	Rattus norvegicus	0-5
21276840-5	2011	In a transient transfection assay, IL-11 (20 ng/ml) increased luciferase activity of the construct (-116 to +60) in ROS 17/2.8 cells and rat bone marrow stromal cells.	ros	116-119	interleukin 11	Rattus norvegicus	35-40
26410814-6	2015	The fluorescence intensity of ROS and the activities of Caspase-3, Caspase-8, and Caspase-9 were increased.	ros	30-33	caspase 8	Homo sapiens	67-76
21479273-12	2011	The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.	ros	19-22	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	34-40
29381135-2	2018	While microtubule de-tyrosination has been suggested to increase stiffness and Nox2 ROS production in isolated single myofibers, its role in altering tissue stiffness and muscle function has not been established.	ros	84-87	cytochrome b-245, beta polypeptide	Mus musculus	79-83
20717837-4	2011	Furthermore, we find that in mice fed with a restricted diet, a regimen known to increase the intracellular level of ROS, PrP(-/-) thymocytes are more sensitive to oxidative stress.	ros	117-120	prion protein	Mus musculus	122-125
26265052-7	2015	We proposed a redox regulator role for Prdx6 in regulating and maintaining cellular homeostasis via its ability to control ROS levels that could otherwise accelerate the emergence of prion-related neuropathology.	ros	123-126	peroxiredoxin 6	Mus musculus	39-44
26531283-0	2015	Atorvastatin improves cardiac function of rats with chronic cardiac failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release.	ros	121-124	Rac family small GTPase 1	Rattus norvegicus	91-95
29381135-4	2018	Eliminating Nox2 ROS prevents microtubule disorganization and reduces fibrosis and muscle stiffness in mdx diaphragm.	ros	17-20	cytochrome b-245, beta polypeptide	Mus musculus	12-16
26531283-0	2015	Atorvastatin improves cardiac function of rats with chronic cardiac failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release.	ros	121-124	neutrophil cytosolic factor 1	Rattus norvegicus	96-103
26531283-9	2015	CONCLUSIONS: Atorvastatin may improve cardiac function of rats with heart failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release.	ros	127-130	Rac family small GTPase 1	Rattus norvegicus	97-101
29381135-6	2018	Ultimately, inhibiting Nox2 ROS production increased force and respiratory function in dystrophic diaphragm, establishing Nox2 as a potential therapeutic target in Duchenne muscular dystrophy.	ros	28-31	cytochrome b-245, beta polypeptide	Mus musculus	23-27
26531283-9	2015	CONCLUSIONS: Atorvastatin may improve cardiac function of rats with heart failure via inhibiting Rac1/P47phox/P67phox-mediated ROS release.	ros	127-130	neutrophil cytosolic factor 1	Rattus norvegicus	102-109
21619840-10	2011	CONCLUSION: High expression of SOD2 below 3.71 times can reduce intracellular ROS level in HEI-OC1 cells, while SOD2 C47T mutation had no effect on them.	ros	78-81	superoxide dismutase 2	Homo sapiens	31-35
29381135-6	2018	Ultimately, inhibiting Nox2 ROS production increased force and respiratory function in dystrophic diaphragm, establishing Nox2 as a potential therapeutic target in Duchenne muscular dystrophy.	ros	28-31	cytochrome b-245, beta polypeptide	Mus musculus	122-126
29307831-0	2018	Arsenic trioxide induces autophagic cell death in osteosarcoma cells via the ROS-TFEB signaling pathway.	ros	77-80	transcription factor EB	Homo sapiens	81-85
20980255-7	2011	Furthermore, mTORC2 down-regulation decreased PGE(2)-induced production of the chemokine monocyte chemoattractant protein-1 (CCL2), which was linked to a significant reduction in ROS production.	ros	179-182	CREB regulated transcription coactivator 2	Mus musculus	13-19
29307831-8	2018	Furthermore, NAC, an ROS scavenger, abrogated the effects of ATO on TFEB-dependent autophagic cell death.	ros	21-24	transcription factor EB	Homo sapiens	68-72
21123941-7	2011	Accumulation of unrepaired DNA following XPC silencing increased DNA-dependent protein kinase activity, which subsequently activated AKT1 and NADPH oxidase-1 (NOX1), resulting in ROS production and accumulation of specific deletions in mitochondrial DNA (mtDNA) over time.	ros	179-182	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	41-44
26117316-5	2015	We determined that enhanced Ce(3+)/Ce(4+) ratios improved intracellular dispersion and that the ameliorated intracellular distribution of CNPs-AL-PEG contributes to the elevated expression of SOD2, which leads to increased protection of normal cells against ROS and reduces the oxidatively generated DNA damage.	ros	258-261	superoxide dismutase 2	Homo sapiens	192-196
29375538-6	2017	Moreover, ROS was involved in CSFV-induced IL-8 production.	ros	10-13	C-X-C motif chemokine ligand 8	Sus scrofa	43-47
26143630-7	2015	Cardiac NLRP3 inflammasome was activated with elevated myocardial IL-1beta and IL-18 concentrations mediated by ROS over-production and TXNIP over-expression in MI dogs.	ros	112-115	interleukin 18	Canis lupus familiaris	79-84
21123941-7	2011	Accumulation of unrepaired DNA following XPC silencing increased DNA-dependent protein kinase activity, which subsequently activated AKT1 and NADPH oxidase-1 (NOX1), resulting in ROS production and accumulation of specific deletions in mitochondrial DNA (mtDNA) over time.	ros	179-182	NADPH oxidase 1	Homo sapiens	142-157
21123941-7	2011	Accumulation of unrepaired DNA following XPC silencing increased DNA-dependent protein kinase activity, which subsequently activated AKT1 and NADPH oxidase-1 (NOX1), resulting in ROS production and accumulation of specific deletions in mitochondrial DNA (mtDNA) over time.	ros	179-182	NADPH oxidase 1	Homo sapiens	159-163
21123941-10	2011	Our results demonstrate that genomic instability resulting from XPC silencing results in activation of AKT1 and subsequently NOX1 to induce ROS generation, mtDNA deletions, and neoplastic transformation in human keratinocytes.	ros	140-143	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	64-67
21123941-10	2011	Our results demonstrate that genomic instability resulting from XPC silencing results in activation of AKT1 and subsequently NOX1 to induce ROS generation, mtDNA deletions, and neoplastic transformation in human keratinocytes.	ros	140-143	NADPH oxidase 1	Homo sapiens	125-129
29375538-7	2017	Subsequent studies demonstrated that ROS was involved in MAVS-induced IL-8 production and CSFV induced ROS production through MAVS pathway.	ros	37-40	mitochondrial antiviral signaling protein	Sus scrofa	57-61
21266258-1	2011	Oxidative and nitrosative stress result in the accumulation of reactive oxygen and nitrogen species (ROS/RNS) which trigger redox-mediated signaling cascades through posttranslational modifications on cysteine residues, including S-nitrosylation (P-SNO) and S-glutathionylation (P-SSG).	ros	101-104	strawberry notch homolog 1	Homo sapiens	249-252
26406250-6	2015	Here we show that cardioviruses manipulate another PI4K, namely the ER-localized phosphatidylinositol 4-kinase III alpha (PI4KA), to generate PI4P-enriched ROs.	ros	156-159	phosphatidylinositol 4-kinase alpha	Homo sapiens	122-127
26406250-8	2015	We reveal that the EMCV nonstructural protein 3A interacts with and is responsible for PI4KA recruitment to viral ROs.	ros	114-117	phosphatidylinositol 4-kinase alpha	Homo sapiens	87-92
29375538-7	2017	Subsequent studies demonstrated that ROS was involved in MAVS-induced IL-8 production and CSFV induced ROS production through MAVS pathway.	ros	37-40	C-X-C motif chemokine ligand 8	Sus scrofa	70-74
22046279-4	2011	We demonstrate that CO enhances SUMOylation of PPARgamma which we find was attributed to mitochondrial ROS generation.	ros	103-106	peroxisome proliferator activated receptor gamma	Mus musculus	47-56
29375538-7	2017	Subsequent studies demonstrated that ROS was involved in MAVS-induced IL-8 production and CSFV induced ROS production through MAVS pathway.	ros	103-106	mitochondrial antiviral signaling protein	Sus scrofa	126-130
29375538-8	2017	These results indicate that CSFV induces IL-8 production through MAVS pathway and production of ROS.	ros	96-99	C-X-C motif chemokine ligand 8	Sus scrofa	41-45
29872720-6	2018	Mechanistically, VC uptake via SVCT-2 increased intracellular ROS, and subsequently caused DNA damage and ATP depletion, leading to cell cycle arrest and apoptosis.	ros	62-65	solute carrier family 23 member 2	Homo sapiens	31-37
26239661-6	2015	Moreover, treatment with baicalin significantly reduced cell oxidative damage induced by Ang II through MDA/ROS decrease and NO/T-AOC increase.	ros	108-111	angiogenin	Homo sapiens	89-92
25736529-5	2015	In primary striatal neurons, we observed that treatment with the mGluR5 agonist CHPG increased the phosphorylation level of extracellular signal-regulated kinase (ERK), which was dependent on the mGluR5-inositol-1,4,5-trisphosphate-reactive oxygen species (ROS) pathway.	ros	257-260	glutamate receptor, ionotropic, kainate 1	Mus musculus	65-71
25736529-5	2015	In primary striatal neurons, we observed that treatment with the mGluR5 agonist CHPG increased the phosphorylation level of extracellular signal-regulated kinase (ERK), which was dependent on the mGluR5-inositol-1,4,5-trisphosphate-reactive oxygen species (ROS) pathway.	ros	257-260	glutamate receptor, ionotropic, kainate 1	Mus musculus	196-202
25736529-9	2015	Thus, results of the present study suggest that mGluR5 in the NAc shell, but not in the core, is essential for the retrieval of morphine contextual memory, which is mediated at least in part, through the ROS/ERK signaling pathway.	ros	204-207	glutamate receptor, ionotropic, kainate 1	Mus musculus	48-54
26001727-0	2015	c-Jun N-terminal kinase attenuates TNFalpha signaling by reducing Nox1-dependent endosomal ROS production in vascular smooth muscle cells.	ros	91-94	NADPH oxidase 1	Homo sapiens	66-70
29128359-7	2018	This study also showed that UCH-L1 promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS by deubiquitination of NOX4, suggesting that UCH-L1 plays a key role in angiogenesis of HUVECS by regulating ROS levels by deubiquitination of NOX4.	ros	122-125	NADPH oxidase 4	Homo sapiens	149-153
26001727-11	2015	These data suggest that JNK suppresses the inflammatory response to TNFalpha by reducing Nox1-dependent endosomal ROS production.	ros	114-117	NADPH oxidase 1	Homo sapiens	89-93
28295305-10	2018	Taken together, we found that DOX induced mitochondrial ROS release to activate ERK-mediated HSF2 nuclear translocation and AT1 R upregulation causing DOX-damaged heart failure in vitro and in vivo.	ros	56-59	angiotensin II receptor type 1	Homo sapiens	124-129
29080797-8	2017	Adding DNMT1 inhibitor (5-Aza-2dc) or HDAC1 inhibitor (LBH589) depressed the up-regulation of DNMT1 or HDAC1 expression, the decreases of GSH levels and increases of ROS production induced by OTA, respectively.	ros	166-169	histone deacetylase 1	Sus scrofa	38-43
26232188-2	2015	The estrogen receptors (ERs) ratio is important in the maintenance of mitochondrial redox status, and higher levels of ERbeta increases mitochondrial functionality, decreasing ROS production.	ros	176-179	estrogen receptor 2	Homo sapiens	119-125
26232188-9	2015	In CDDP-treated cells, the overexpression of ERbeta in MCF-7 caused a reduction in apoptosis, autophagy and ROS production, leading to higher cell survival; and the silencing of ERbeta in T47D cells promoted the opposite effects.	ros	108-111	estrogen receptor 2	Homo sapiens	45-51
29435131-5	2018	The expression of HIF-1alpha and YAP1 was concomitantly decreased by PD-L1 silencing or by ROS scavenger treatment (N-acetylcysteine, NAC); however, a ROS inducer treatment (pyocyanin) completely reversed the decreased expression of both genes in EGFR-mutated and -wild-type (WT) NSCLC cells.	ros	91-94	Yes1 associated transcriptional regulator	Homo sapiens	33-37
29435131-5	2018	The expression of HIF-1alpha and YAP1 was concomitantly decreased by PD-L1 silencing or by ROS scavenger treatment (N-acetylcysteine, NAC); however, a ROS inducer treatment (pyocyanin) completely reversed the decreased expression of both genes in EGFR-mutated and -wild-type (WT) NSCLC cells.	ros	151-154	Yes1 associated transcriptional regulator	Homo sapiens	33-37
29435131-7	2018	Mechanistic studies indicated that upregulation of YAP1 by PD-L1 might be responsible for EGFR mutation-independent TKI resistance via the ROS/HIF-1alpha axis.	ros	139-142	Yes1 associated transcriptional regulator	Homo sapiens	51-55
28916476-8	2017	These data indicate that in cells with an intact PARP-associated DNA repair system, ascorbate-induced cell death is caused by NAD+ and ATP depletion, while in the absence of PARP activation ascorbate-induced cell death still occurs but is a consequence of ROS-induced DNA damage.	ros	256-259	collagen type XI alpha 2 chain	Homo sapiens	49-53
25917637-5	2015	The inhibitor of NF-kappaB and ROS scavenger were exploited to analyze the mechanism of NOD2 up-regulation in chondrocytes treated with T-2 toxin.	ros	31-34	nucleotide binding oligomerization domain containing 2	Homo sapiens	88-92
25917637-9	2015	Furthermore, up-regulation of NOD2 expression induced by T-2 toxin could be abrogated by pretreating the cells with inhibitors of NF-kappaB and scavenger of ROS.	ros	157-160	nucleotide binding oligomerization domain containing 2	Homo sapiens	30-34
25917637-10	2015	CONCLUSION: T-2 toxin could up-regulate NOD2 expression via ROS/NF-kappaB pathway and activate NOD2 signaling pathway.	ros	60-63	nucleotide binding oligomerization domain containing 2	Homo sapiens	40-44
29204124-10	2017	The full length NOX4 is significantly upregulated in ischemic cardiomyopathy suggesting a role for NOX4 in ROS production during heart failure.	ros	107-110	NADPH oxidase 4	Homo sapiens	16-20
26210298-4	2015	To date, however, the exact role of vitamin C and its transporter (SVCT2) in ROS regulated autophagy and apoptosis in BMSCs is poorly understood.	ros	77-80	solute carrier family 23 member 2	Homo sapiens	67-72
26349987-3	2015	Our results provide novel insight that UCP2 may protect hippocampal neurons exposed to amyloid beta protein through decreasing ROS production.	ros	127-130	uncoupling protein 2	Homo sapiens	39-43
26314448-6	2015	The washed platelets were incubated with PDI inhibitor before stimulation with different stimulin, PMA, dibucaine or collagen, and then GPIbalpha was cleaved and ROS levels were elevated more than that in the controls.	ros	162-165	prolyl 4-hydroxylase subunit beta	Homo sapiens	41-44
29204124-10	2017	The full length NOX4 is significantly upregulated in ischemic cardiomyopathy suggesting a role for NOX4 in ROS production during heart failure.	ros	107-110	NADPH oxidase 4	Homo sapiens	99-103
26002466-5	2015	In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1alpha-induced expression of C/EBPbeta and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2).	ros	203-206	mitogen activated protein kinase 14	Rattus norvegicus	44-80
28942285-11	2017	Furthermore, our results showed that AF repressed the expression of Skp2 through ROS/AMPK/mTOR signaling.	ros	81-84	S-phase kinase associated protein 2	Homo sapiens	68-72
26002466-5	2015	In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1alpha-induced expression of C/EBPbeta and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2).	ros	203-206	C-X-C motif chemokine ligand 12	Rattus norvegicus	175-180
26017975-9	2015	TNF effects on TRPC6 trafficking required ROS.	ros	42-45	transient receptor potential cation channel subfamily C member 6	Homo sapiens	15-20
29141388-16	2017	Conclusion: SMP-30 overexpression plays a protective role in UVB-induced apoptosis via regulating the expression of apoptosis-related proteins and inhibiting the production of ROS in HLE-B3 cells.	ros	176-179	regucalcin	Homo sapiens	12-18
25910810-6	2015	More pronounced control of the respiratory rate, membrane potential, and ROS by UCP2 was observed in these mitochondria.	ros	73-76	uncoupling protein 2	Homo sapiens	80-84
25910810-7	2015	A greater UCP2-mediated decrease in ROS generation indicates an improved antioxidative role for UCP2 under high glucose conditions.	ros	36-39	uncoupling protein 2	Homo sapiens	10-14
25910810-7	2015	A greater UCP2-mediated decrease in ROS generation indicates an improved antioxidative role for UCP2 under high glucose conditions.	ros	36-39	uncoupling protein 2	Homo sapiens	96-100
29296173-8	2017	In addition, we demonstrated that RMF-HGF showed an up-regulation of an ROS-generating enzyme, NADPH oxidase 4 (Nox4).	ros	72-75	hepatocyte growth factor	Homo sapiens	34-41
25910810-9	2015	UCP2 gene silencing led to elevated mitochondrial ROS formation and ICAM1 expression, especially in high glucose-cultured cells.	ros	50-53	uncoupling protein 2	Homo sapiens	0-4
25910810-13	2015	Our results indicate that endothelial UCP2 may function as a sensor and negative regulator of mitochondrial ROS production in response to hyperglycemia.	ros	108-111	uncoupling protein 2	Homo sapiens	38-42
29296173-8	2017	In addition, we demonstrated that RMF-HGF showed an up-regulation of an ROS-generating enzyme, NADPH oxidase 4 (Nox4).	ros	72-75	NADPH oxidase 4	Homo sapiens	95-110
29296173-8	2017	In addition, we demonstrated that RMF-HGF showed an up-regulation of an ROS-generating enzyme, NADPH oxidase 4 (Nox4).	ros	72-75	NADPH oxidase 4	Homo sapiens	112-116
29296173-10	2017	We have further shown that scavenging ROS with EcSOD significantly inhibited RMF-HGF-stimulated orthotopic tumor growth of MDA-MB231.	ros	38-41	hepatocyte growth factor	Homo sapiens	77-84
28444875-8	2017	Collectively, this study showed that MGO-induced apoptosis is dependent on c-FLIPL down-regulation via ROS-mediated down-regulation of p65 expression in endothelial cells.	ros	103-106	RELA proto-oncogene, NF-kB subunit	Homo sapiens	135-138
25934926-10	2015	Finally, we observed that antibody-mediated cross-linking of hCD13, expressed in the murine macrophage-like J774 cell line, induces production of ROS.	ros	146-149	alanyl aminopeptidase, membrane	Homo sapiens	61-66
25963661-3	2015	Here we found that PGC-1alpha directly interacted with Bhlhe40, a basic helix-loop-helix (bHLH) transcriptional repressor induced by hypoxia, and protects SKM from ROS damage, and they cooccupied PGC-1alpha-targeted gene promoters/enhancers, which in turn repressed PGC-1alpha transactivational activity.	ros	164-167	basic helix-loop-helix family member e40	Homo sapiens	55-62
25963661-5	2015	Knockdown of Bhlhe40 mRNA increased levels of ROS, fatty acid oxidation, mitochondrial DNA, and expression of PGC-1alpha target genes.	ros	46-49	basic helix-loop-helix family member e40	Homo sapiens	13-20
28780280-3	2017	Further, there were significant downregulations of GDNF/ERK1/2/ROS and PI3K/AKT/NOX signaling pathways in the hippocampus and prefrontal cortex in depressed mice.	ros	63-66	glial cell line derived neurotrophic factor	Mus musculus	51-55
28780280-3	2017	Further, there were significant downregulations of GDNF/ERK1/2/ROS and PI3K/AKT/NOX signaling pathways in the hippocampus and prefrontal cortex in depressed mice.	ros	63-66	mitogen-activated protein kinase 3	Mus musculus	56-62
28780280-5	2017	These results suggest that Schisandrin produces an antidepressant-like effect in CUMS-induced mice, which possibly mediated, at least in part, by rectifying the signaling pathways of GDNF/ERK1/2/ROS and PI3K/AKT/NOX.	ros	195-198	glial cell line derived neurotrophic factor	Mus musculus	183-187
25915537-1	2015	This study explored the role of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in the production of ROS and tumor invasion.	ros	96-99	ubiquitin carboxy-terminal hydrolase L1	Mus musculus	32-65
29068360-3	2017	Moreover, activated platelets release soluble CD40 ligand (sCD40L), which in turn contributes to oxidative imbalance, triggering the release of reactive oxidative species (ROS) on various cellular types.	ros	172-175	CD40 molecule	Homo sapiens	46-50
25915537-1	2015	This study explored the role of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in the production of ROS and tumor invasion.	ros	96-99	ubiquitin carboxy-terminal hydrolase L1	Mus musculus	67-73
25915537-2	2015	UCH-L1 was found to increase cellular ROS levels and promote cell invasion.	ros	38-41	ubiquitin carboxy-terminal hydrolase L1	Mus musculus	0-6
28830815-7	2017	Furthermore, CsA increased mitochondrial membrane potential and intracellular ROS production in insulin-resistant C2C12 cells, and inhibition of ROS production with SS-31 suppressed CsA-induced O-GlcNAcylation.	ros	78-81	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	13-16
25448035-6	2015	Studies in different model systems demonstrated a role for NAF-1 and mNT in the regulation of cellular iron, calcium and ROS homeostasis, and uncovered a key role for NEET proteins in critical processes, such as cancer cell proliferation and tumor growth, lipid and glucose homeostasis in obesity and diabetes, control of autophagy, longevity in mice, and senescence in plants.	ros	121-124	nuclear assembly factor 1 ribonucleoprotein	Mus musculus	59-64
25871519-6	2015	Our results showed that administration of FGF21 significantly improved behavioral performance of d-gal-treated mice in water maze task and step-down test, reduced brain cell damage in the hippocampus, and attenuated the d-gal-induced production of MDA, ROS and advanced glycation end products (AGEs).	ros	253-256	fibroblast growth factor 21	Mus musculus	42-47
21904662-6	2011	Measurement of oxidized lipids in whole lung from transgenic mice expressing a mutation in the BMPR2 cytoplasmic tail showed a 50% increase in isoprostanes and a twofold increase in isofurans, suggesting increased ROS of mitochondrial origin.	ros	214-217	bone morphogenetic protein receptor, type II (serine/threonine kinase)	Mus musculus	95-100
21099361-7	2010	In addition, p53-induced increases in intracellular levels of ROS were also inhibited in cells overexpressing Nek6.	ros	62-65	NIMA related kinase 6	Homo sapiens	110-114
28830815-7	2017	Furthermore, CsA increased mitochondrial membrane potential and intracellular ROS production in insulin-resistant C2C12 cells, and inhibition of ROS production with SS-31 suppressed CsA-induced O-GlcNAcylation.	ros	145-148	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	182-185
28830815-8	2017	In summary, our results suggest that CsA treatment induced apoptosis in insulin-resistant C2C12 cells, partly via CsA-induced ROS production and resultant O-GlcNAcylation, indicating that O-GlcNAcylation serves as a potent therapeutical target for organ transplantation.	ros	126-129	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	37-40
28830815-8	2017	In summary, our results suggest that CsA treatment induced apoptosis in insulin-resistant C2C12 cells, partly via CsA-induced ROS production and resultant O-GlcNAcylation, indicating that O-GlcNAcylation serves as a potent therapeutical target for organ transplantation.	ros	126-129	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	114-117
28946937-10	2017	Our data also suggest that secreted IL-6 regulates CLB2.0-induced MUC5AC and MUC1 expression via ROS-mediated downregulation of claudin-1 expression to maintain mucus homeostasis in the airway.	ros	97-100	mucin 1, cell surface associated	Homo sapiens	77-81
20571037-8	2010	Zymosan-stimulated production of ROS was increased dramatically in a M-CSF-dependent manner in Lnk KO macrophages.	ros	33-36	SH2B adaptor protein 3	Mus musculus	95-98
28655711-2	2017	Our studies identified a highly up-regulated mammalian lncRNA, FOXD3-AS1, known as linc1623 in mice, in the setting of hyperoxia/reactive oxygen species (ROS)-induced lung injury.	ros	154-157	FOXD3 antisense RNA 1	Homo sapiens	63-72
28653157-12	2017	CONCLUSION: SH-GQDs have target specificity to macrophage scavenger receptor (MSR) and efficiently recovered the ROS levels and TEER.	ros	113-116	macrophage scavenger receptor 1	Mus musculus	78-81
28979688-8	2017	In vitro, flow cytometry showed that human recombinant IL-25 (rIL-25) led to increased cell apoptosis and ROS in the human epithelial cell line 16HBE in a dose and time-dependent fashion.	ros	106-109	interleukin 25	Rattus norvegicus	62-68
28596380-3	2017	However, apo-hemopexin is vulnerable to inactivation by reactive nitrogen (RNS) and oxygen species (ROS) that covalently modify amino acids.	ros	100-103	hemopexin	Homo sapiens	13-22
28824425-7	2017	Furthermore, Rb1 pretreatment could inhibit TNF-alpha-induced ROS and MDA production; increase the activities of SOD, CAT, and GSH-Px; and decrease the levels of IL-1beta, IL-6, VCAM-1, ICAM-1, VEGF, MMP-2 and MMP-9.	ros	62-65	RB transcriptional corepressor 1	Homo sapiens	13-16
28106298-8	2017	Inhibiting as well as silencing of IP3 R receptor also resulted in increase in ROS production which was abolished after pretreatment with N-acetyl cysteine.	ros	79-82	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	35-40
28389561-6	2017	The present study assessed the mechanism of how TGF-beta-1-induced CD44V6 regulates the NOX4/reactive oxygen species (ROS) signaling that mediates the myofibroblast differentiation.	ros	118-121	transforming growth factor, beta 1	Mus musculus	48-58
28389561-6	2017	The present study assessed the mechanism of how TGF-beta-1-induced CD44V6 regulates the NOX4/reactive oxygen species (ROS) signaling that mediates the myofibroblast differentiation.	ros	118-121	NADPH oxidase 4	Mus musculus	88-92
28389561-7	2017	Specifically, we found that NOX4/ROS regulates hyaluronan synthesis and the transcription of CD44V6 via an effect upon AP-1 activity.	ros	33-36	NADPH oxidase 4	Mus musculus	28-32
28389561-8	2017	Further, CD44V6 is part of a positive-feedback loop with TGFbeta1/TGFbetaRI signaling that acts to increase NOX4/ROS production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility.	ros	113-116	transforming growth factor, beta 1	Mus musculus	57-65
28389561-8	2017	Further, CD44V6 is part of a positive-feedback loop with TGFbeta1/TGFbetaRI signaling that acts to increase NOX4/ROS production, which is required for myofibroblast differentiation, myofibroblast differentiation, myofibroblast extracellular matrix production, myofibroblast invasion, and myofibroblast contractility.	ros	113-116	NADPH oxidase 4	Mus musculus	108-112
28614802-7	2017	Elevated ROS was associated with downregulated mitochondrial SOD2.	ros	9-12	superoxide dismutase 2	Homo sapiens	61-65
28593945-3	2017	Upon NOD2 stimulation of human macrophages, LACC1 associates with the NOD2-signalling complex, and is critical for optimal NOD2-induced signalling, mitochondrial ROS (mtROS) production, cytokine secretion and bacterial clearance.	ros	162-165	nucleotide binding oligomerization domain containing 2	Homo sapiens	5-9
28593945-3	2017	Upon NOD2 stimulation of human macrophages, LACC1 associates with the NOD2-signalling complex, and is critical for optimal NOD2-induced signalling, mitochondrial ROS (mtROS) production, cytokine secretion and bacterial clearance.	ros	162-165	nucleotide binding oligomerization domain containing 2	Homo sapiens	70-74
28593945-3	2017	Upon NOD2 stimulation of human macrophages, LACC1 associates with the NOD2-signalling complex, and is critical for optimal NOD2-induced signalling, mitochondrial ROS (mtROS) production, cytokine secretion and bacterial clearance.	ros	162-165	nucleotide binding oligomerization domain containing 2	Homo sapiens	70-74
28403150-11	2017	Conditioned media from macrophages exposed to PEDF induced tumor cells apoptosis in contrast to control conditioned media suggesting that ROS may be involved in tumor cells apoptosis.	ros	138-141	serpin family F member 1	Homo sapiens	46-50
27748761-0	2017	Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury.	ros	118-121	cofilin 1	Homo sapiens	19-28
27748761-8	2017	We observed that HDACi induced ROS accumulation in cells and apoptosis via promotion of the CFL-1 interaction with Bax and CFL-1 translocation to the mitochondria, resulting in cytochrome C release.	ros	31-34	cofilin 1	Homo sapiens	92-97
27748761-8	2017	We observed that HDACi induced ROS accumulation in cells and apoptosis via promotion of the CFL-1 interaction with Bax and CFL-1 translocation to the mitochondria, resulting in cytochrome C release.	ros	31-34	cofilin 1	Homo sapiens	123-128
27131982-5	2017	This was accompanied by an early induction of P38 MAP kinase, which is influenced by ROS and plays an important signaling role for induction of iNOS.	ros	85-88	mitogen activated protein kinase 14	Rattus norvegicus	46-60
28165467-13	2017	We also found that TGF-beta stimulated ROS generation in primary mouse mesangial cells (pMMCs) from wild-type, Nox1 KO, and Duox1 KO mice, but did not induce Nox activity in pMMCs from Nox2 knockout (KO), Nox4 KO, or Duox2 KO mice.	ros	39-42	transforming growth factor, beta 1	Mus musculus	19-27
28165467-13	2017	We also found that TGF-beta stimulated ROS generation in primary mouse mesangial cells (pMMCs) from wild-type, Nox1 KO, and Duox1 KO mice, but did not induce Nox activity in pMMCs from Nox2 knockout (KO), Nox4 KO, or Duox2 KO mice.	ros	39-42	NADPH oxidase 1	Mus musculus	111-115
28165467-14	2017	These results indicate that activating Nox2, Nox4, or Duox2 in pMMCs is essential for TGF-beta-mediated ROS generation.	ros	104-107	cytochrome b-245, beta polypeptide	Mus musculus	39-43
28165467-14	2017	These results indicate that activating Nox2, Nox4, or Duox2 in pMMCs is essential for TGF-beta-mediated ROS generation.	ros	104-107	NADPH oxidase 4	Mus musculus	45-49
28165467-14	2017	These results indicate that activating Nox2, Nox4, or Duox2 in pMMCs is essential for TGF-beta-mediated ROS generation.	ros	104-107	transforming growth factor, beta 1	Mus musculus	86-94
28302174-13	2017	CONCLUSION: Our data demonstrate induction of a ROS/p38 MAPK -mediated feedback inhibitory pathway by oxy-cholesterol and steroid intermediates and products attenuates steroidogenesis via inhibition of CREB transcriptional activity.	ros	48-51	mitogen-activated protein kinase 14	Mus musculus	52-60
26029922-0	2015	Autophagy-Regulated ROS from Xanthine Oxidase Acts as an Early Effector for Triggering Late Mitochondria-Dependent Apoptosis in Cathepsin S-Targeted Tumor Cells.	ros	20-23	cathepsin S	Homo sapiens	128-139
26029922-3	2015	In our previous studies, we have observed that CTSS inhibition induces autophagy, which is responsible for up-regulating xanthine oxidase for early ROS generation and consequent cell death.	ros	148-151	cathepsin S	Homo sapiens	47-51
28255277-14	2017	Overexpression of PGC-1alpha blocked SIRT3 knockdown-induced decrease of SOD2 expression, increase of ROS level, and decrease of mitochondrial function and biogenesis, leading to improvement of osteogenesis.	ros	102-105	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	18-28
26078795-10	2015	Collectively, inhibition of KCa3.1 channel suppressed the growth and migration, and promoted the apoptosis of human hepatocellular carcinoma cells by regulating intracellular ROS level and promoting p53 activation.	ros	175-178	potassium calcium-activated channel subfamily N member 4	Homo sapiens	28-34
25804308-0	2015	ROS and endothelial nitric oxide synthase (eNOS)-dependent trafficking of angiotensin II type 2 receptor begets neuronal NOS in cardiac myocytes.	ros	0-3	angiotensin II receptor type 2	Homo sapiens	74-104
26856715-11	2017	Functional inhibition of the AhR and AhR-/ARNT-defective cell lines demonstrate that the AhR/ARNT pathway is mandatory for the observed ROS defence caused by ICZ, supporting the hypothesis that AhR-mediated regulation of defence genes is involved.	ros	136-139	aryl hydrocarbon receptor	Homo sapiens	29-32
25804308-5	2015	Inhibition of AT1R or ROS scavengers prevented Ang II-induced translocation of AT2R to plasma membrane, suggesting an alignment of AT1R-ROS-AT2R.	ros	22-25	angiotensin II receptor type 1	Homo sapiens	131-135
25804308-11	2015	Taken together, we demonstrate, for the first time, that Ang II upregulates nNOS protein expression and activity via AT1R/ROS/eNOS-dependent S-nitrosation and membrane translocation of AT2R.	ros	122-125	nitric oxide synthase 1	Homo sapiens	76-80
25770995-6	2015	Upon radiation, SeC@MSNs-Tf/TAT promoted intracellular ROS overproduction, which induced apoptotic cell death by affecting p53, AKT and MAPKs pathways.	ros	55-58	eukaryotic elongation factor, selenocysteine-tRNA-specific	Mus musculus	16-19
20363070-5	2010	Accumulation of ROS was observed only in malignant cell lines, which displayed a compromised redox status evident from enhanced NADP(+)/NADPH and GSSG/GSH ratios and a concomitant decrease in glutathione reductase level and activity at 24h following treatment.	ros	16-19	glutathione-disulfide reductase	Homo sapiens	192-213
20890104-3	2010	Our research into mechanisms of TSC2 regulation helped uncover a pathway upstream of TSC2 that is regulated by cytoplasmic ATM in response to ROS initiated by ATM activation of LKB1 and AMPK.	ros	142-145	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	186-190
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	ros	120-123	matrix metallopeptidase 2	Homo sapiens	39-44
25652229-3	2015	We investigated the role of cellular iron status in determining the expression and dynamics of IRP-1 in two renal cell types, with the aim of identifying a role of the protein in cellular ROS levels, citrate metabolism and glutamate production.	ros	188-191	aconitase 1	Rattus norvegicus	95-100
26856715-11	2017	Functional inhibition of the AhR and AhR-/ARNT-defective cell lines demonstrate that the AhR/ARNT pathway is mandatory for the observed ROS defence caused by ICZ, supporting the hypothesis that AhR-mediated regulation of defence genes is involved.	ros	136-139	aryl hydrocarbon receptor	Homo sapiens	37-40
20512627-10	2010	The ROS scavenger NAC efficiently suppressed not only ROS generation, but also caspase-3-mediated PARP cleavage, apoptosis, and release of cytochrome c and AIF, indicating a role of ROS in combined Dox + DMPS treatment-induced apoptotic death signaling.	ros	4-7	collagen type XI alpha 2 chain	Homo sapiens	98-102
26856715-11	2017	Functional inhibition of the AhR and AhR-/ARNT-defective cell lines demonstrate that the AhR/ARNT pathway is mandatory for the observed ROS defence caused by ICZ, supporting the hypothesis that AhR-mediated regulation of defence genes is involved.	ros	136-139	aryl hydrocarbon receptor	Homo sapiens	37-40
26856715-11	2017	Functional inhibition of the AhR and AhR-/ARNT-defective cell lines demonstrate that the AhR/ARNT pathway is mandatory for the observed ROS defence caused by ICZ, supporting the hypothesis that AhR-mediated regulation of defence genes is involved.	ros	136-139	aryl hydrocarbon receptor	Homo sapiens	37-40
28142292-6	2017	The radioprotective properties of Prx6 are based, on the one hand, on the capability for ROS neutralization, and on the other hand - on the potentiality for activation of reparation processes of the cell under oxidative stress conditions.	ros	89-92	peroxiredoxin 6	Homo sapiens	34-38
20681789-6	2010	Treatment with the ROS scavenger DMSO dramatically reduced the effects of localized root irradiation on the induction of HR and expression of the AtRAD54 gene in bystander tissues, suggesting that ROS play a critical role in mediating the bystander mutagenic effects in plants.	ros	19-22	DNA repair/recombination protein	Arabidopsis thaliana	146-153
20681789-6	2010	Treatment with the ROS scavenger DMSO dramatically reduced the effects of localized root irradiation on the induction of HR and expression of the AtRAD54 gene in bystander tissues, suggesting that ROS play a critical role in mediating the bystander mutagenic effects in plants.	ros	197-200	DNA repair/recombination protein	Arabidopsis thaliana	146-153
25928429-5	2015	Knockdown of TIGAR exacerbated DNA damage and the effects were partly reversed by the supplementation of PPP products NADPH, ribose, or the ROS scavenger NAC.	ros	140-143	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	13-18
27718123-12	2017	PPARgamma also enhanced the anti-oxidants molecules like Cu/Zn-SOD, Mn-SOD, and hemeoxygenase-1 by reducing the generation of ROS, even in the presence of H2O2.	ros	126-129	peroxisome proliferator activated receptor gamma	Mus musculus	0-9
28009871-8	2017	Cell proliferation was suppressed in HT-29 cells at 10.0 and 20.0 mug ml-1 GAE and this was accompanied by increased intracellular ROS production as well as decreased TNF-alpha, IL-1beta, IL-6, and NF-kappaB1 expressions at 20.0 mug ml-1 GAE.	ros	131-134	interleukin 17F	Homo sapiens	70-74
20152832-6	2010	Apelin-13 reduced serum deprivation (SD)-induced ROS generation, mitochondria depolarization, cytochrome c release and activation of caspase-3.	ros	49-52	apelin	Mus musculus	0-6
29250536-2	2017	ROS is a common activator of NLR/caspase-1.	ros	0-3	caspase 1	Mus musculus	33-42
20347035-6	2010	NOX1 was determined to be crucial for enhanced ROS production in intermittent hypoxia that in turn mediated induction of Nrf2 and Trx1.	ros	47-50	NADPH oxidase 1	Homo sapiens	0-4
20145198-6	2010	Moreover, the addition of NAC, a scavenger of ROS, abrogated the rVpr-induced formation of OxPC, the phosphorylation of C/EBP-beta, a substrate of MAPK, and IL-6 production.	ros	46-49	CCAAT enhancer binding protein beta	Homo sapiens	120-130
25659487-8	2015	We also demonstrated that Pyk2 plays a crucial role in ROS generation during hypoxic stress and that this Pyk2-dependent generation of ROS is necessary for the activation of hypoxia-inducible factor-1alpha, a key molecule in the pathogenesis of hypoxia-induced PH.	ros	55-58	PTK2 protein tyrosine kinase 2 beta	Mus musculus	26-30
25659487-8	2015	We also demonstrated that Pyk2 plays a crucial role in ROS generation during hypoxic stress and that this Pyk2-dependent generation of ROS is necessary for the activation of hypoxia-inducible factor-1alpha, a key molecule in the pathogenesis of hypoxia-induced PH.	ros	55-58	PTK2 protein tyrosine kinase 2 beta	Mus musculus	106-110
25659487-8	2015	We also demonstrated that Pyk2 plays a crucial role in ROS generation during hypoxic stress and that this Pyk2-dependent generation of ROS is necessary for the activation of hypoxia-inducible factor-1alpha, a key molecule in the pathogenesis of hypoxia-induced PH.	ros	135-138	PTK2 protein tyrosine kinase 2 beta	Mus musculus	26-30
25659487-8	2015	We also demonstrated that Pyk2 plays a crucial role in ROS generation during hypoxic stress and that this Pyk2-dependent generation of ROS is necessary for the activation of hypoxia-inducible factor-1alpha, a key molecule in the pathogenesis of hypoxia-induced PH.	ros	135-138	PTK2 protein tyrosine kinase 2 beta	Mus musculus	106-110
20044444-13	2010	The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling.	ros	85-88	angiotensin II receptor, type 1a	Rattus norvegicus	78-84
25649767-8	2015	CYP3A5-induced ROS accumulation was found to be a critical upstream regulator of mTORC2 activity, consistent with evidence of reduced GSH redox activity in most clinical HCC specimens with reduced metastatic capacity.	ros	15-18	CREB regulated transcription coactivator 2	Mus musculus	81-87
29250536-10	2017	Conclusion: Deletion of TRPM2 can enhance the activation of caspase-1 and pyroptosis, which may be via modulating ROS production, suggesting that TRPM2 plays a critical role in immune adjustment.	ros	114-117	caspase 1	Mus musculus	60-69
20044444-13	2010	The ANG II-induced inhibition of Kv4.3 mRNA expression was mediated by ANG II-AT(1)R-ROS-p38 MAPK signaling.	ros	85-88	mitogen activated protein kinase 14	Rattus norvegicus	89-92
27924932-12	2016	Overexpression of a constitutively active form of NRF2 (caNRF2) in NOX4 depleted cells rescued most of this phenotype in cultured cells, implying that NRF2 regulation by ROS issued from NOX4 may play an important role in its anti-apoptotic property.	ros	170-173	NADPH oxidase 4	Mus musculus	67-71
19815060-7	2010	Significative correlations were found between the transcriptional activity of caspase-3 and the activity of some other genes related to apoptosis, cell-cycle and ROS detoxification.	ros	162-165	caspase 3	Rattus norvegicus	78-87
27924932-12	2016	Overexpression of a constitutively active form of NRF2 (caNRF2) in NOX4 depleted cells rescued most of this phenotype in cultured cells, implying that NRF2 regulation by ROS issued from NOX4 may play an important role in its anti-apoptotic property.	ros	170-173	NADPH oxidase 4	Mus musculus	186-190
20036412-5	2010	Moreover, the transcriptional expression of mitochondrial inner membrane genes related to ROS production, such as Ucp-2 and Bcl-2, were altered significantly in high ATZ treatment groups.	ros	90-93	BCL2 apoptosis regulator a	Danio rerio	124-129
25949873-2	2015	Here, we present evidence that SF reduced ROS production by downregulating gp91phox expression and activity in TC1 cell tumor associated macrophages (TAMs), while genetic ablation of phagocytic Nox2 activity increased tumor cell proliferation, motility, invasion, and extravasation in vitro.	ros	42-45	cytochrome b-245, beta polypeptide	Mus musculus	75-83
27909964-1	2016	Chronic nickel intoxication caused by parenteral nickel chloride administration (0.5 mg/kg of body weight) to Wistar rats led to ROS generation inducing LPO in erythrocyte membranes and homogenates of renal, liver, and myocardial tissue.	ros	129-132	lactoperoxidase	Rattus norvegicus	153-156
27840125-7	2016	We found that the pre-incubation with N-Acetyl-l-Cysteine (a quinone reductase inducer) or Deferoxamine (an iron chelator) prevents the generation of ROS, restores the autophagy degradation of mHtt and preserves the cell viability in SH-SY5Y cells expressing the polyQ Htt and exposed to DA.	ros	150-153	huntingtin	Homo sapiens	194-197
25295420-0	2015	Mutation in insulin receptor attenuates oxidative stress and apoptosis in pancreatic beta-cells induced by nutrition excess: reduced insulin signaling and ROS.	ros	155-158	insulin receptor	Mus musculus	12-28
19820034-8	2009	Interestingly, ROS generation was higher in adult than newborn mice and so were the levels of NADPH oxidase 4 and SOD 1, 2, 3 isoforms.	ros	15-18	NADPH oxidase 4	Mus musculus	94-125
21136960-8	2009	We further proved that the ROS production was through NADPH oxidase or the mitochondrial electron transport chain and this ROS accumulation resulted in activation of extracellular signal-regulated kinase 1/2 leading to AR-mediated cardiac hypertrophy.	ros	27-30	mitogen activated protein kinase 3	Rattus norvegicus	166-207
27748905-9	2016	Taken together, our data indicated that 8-ADEQ-stimulated apoptosis in HL-60 leukemia cells is due to a Fas-mediated caspase-8-dependent pathway via ROS generation, but also, to a lesser extent cytochrome c release and caspase-9 activation.	ros	149-152	caspase 8	Homo sapiens	117-126
21136960-8	2009	We further proved that the ROS production was through NADPH oxidase or the mitochondrial electron transport chain and this ROS accumulation resulted in activation of extracellular signal-regulated kinase 1/2 leading to AR-mediated cardiac hypertrophy.	ros	123-126	mitogen activated protein kinase 3	Rattus norvegicus	166-207
24964914-5	2015	Photoageing was induced by UVB irradiation through ROS-mediated inflammation, which was related to the depletion of endogenous antioxidants, activation of MMPs and keratinocyte apoptosis.	ros	51-54	matrix metallopeptidase 13	Mus musculus	155-159
26279425-1	2015	BACKGROUND: Angiotensin II/Angiotensin II type 1 receptor (AT1R) effects are dependent on ROS production stimulated by NADPH oxidase activation.	ros	90-93	angiotensin II receptor type 1	Homo sapiens	27-57
26279425-1	2015	BACKGROUND: Angiotensin II/Angiotensin II type 1 receptor (AT1R) effects are dependent on ROS production stimulated by NADPH oxidase activation.	ros	90-93	angiotensin II receptor type 1	Homo sapiens	59-63
27881869-4	2016	Ntn-1 induced the recruitment of NADPH oxidases and Rac1 into membrane lipid rafts to facilitate ROS production.	ros	97-100	netrin 1	Mus musculus	0-5
26510432-1	2015	Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions, such as migration and adhesion.	ros	14-17	NADPH oxidase 1	Homo sapiens	51-55
19787204-1	2009	The present study is the first to evaluate the expression and activity of MnSOD, Cu/ZnSOD and catalase in human gastric samples, since ROS play a significant role in the pathogenesis of different forms of malignancy inducing mutations and various diseases such as gastric cancer.	ros	135-138	superoxide dismutase 2	Homo sapiens	74-79
19482076-0	2009	ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells.	ros	0-3	haptoglobin-related protein	Homo sapiens	61-64
27881869-4	2016	Ntn-1 induced the recruitment of NADPH oxidases and Rac1 into membrane lipid rafts to facilitate ROS production.	ros	97-100	Rac family small GTPase 1	Mus musculus	52-56
19482076-2	2009	Extensive studies have indicated that ROS are involved in 4-HPR-mediated apoptosis.	ros	38-41	haptoglobin-related protein	Homo sapiens	60-63
26510432-1	2015	Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions, such as migration and adhesion.	ros	14-17	NADPH oxidase 4	Homo sapiens	66-70
26583060-7	2015	RESULTS: Hypoxia induces ROS production via hCLOCK.	ros	25-28	clock circadian regulator	Homo sapiens	44-50
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	ros	41-44	haptoglobin-related protein	Homo sapiens	28-31
27881869-5	2016	The Inalpha6beta4 signaling of Ntn-1 through ROS production is uniquely mediated by the activation of SP1 for cell cycle progression and the transcriptional occupancy of SP1 on the VEGF promoter.	ros	45-48	netrin 1	Mus musculus	31-36
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	ros	41-44	haptoglobin-related protein	Homo sapiens	223-226
26583060-11	2015	Overall findings show that hypoxia increases the expression of hCLOCK, which leads to ROS production, which then activates the RhoA and NF-kappaB pathways.	ros	86-89	clock circadian regulator	Homo sapiens	63-69
26583060-12	2015	CONCLUSION: Our findings suggest that hypoxic states induce vascular oxidative damage and inflammation via hCLOCK-mediated production of ROS, with subsequent activation of the RhoA and NF-kappaB pathways.	ros	137-140	clock circadian regulator	Homo sapiens	107-113
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	ros	203-206	haptoglobin-related protein	Homo sapiens	28-31
27816051-0	2016	Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage.	ros	99-102	solute carrier family 9 member C1	Homo sapiens	45-48
19482076-6	2009	Our data also reveal that 4-HPR-mediated ROS evoke Akt conformational change by forming an intramolecular disulfide bond; N-acetylcysteine and glutathione, as thiol antioxidants, significantly abate the ROS generation in 4-HPR-exposed cells.	ros	203-206	haptoglobin-related protein	Homo sapiens	223-226
19482076-8	2009	All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation.	ros	89-92	haptoglobin-related protein	Homo sapiens	46-49
25372487-8	2014	[Pt(acac)2(DMS)] administered to SH-SY5Y cells provokes the increment of ROS, generated by NADPH oxidase, responsible for the PKC-epsilon and PKC-delta activation.	ros	73-76	protein kinase C delta	Homo sapiens	142-151
19457704-8	2009	These results indicated that arecoline-induced CTGF synthesis was mediated by ROS, NF-kappaB, JNK, P38 MAPK pathways and curcumin could be a useful agent in controlling OSF.	ros	78-81	cellular communication network factor 2	Homo sapiens	47-51
26585565-9	2016	In a similar manner, ROS production induced by high glucose was reduced by GLP-1 in the presence of PKCbeta inhibitor.	ros	21-24	protein kinase C beta	Homo sapiens	100-107
27798190-3	2016	Ca2+ release from the endoplasmic reticulum, mediated by both the IP3R1 and ryanodine receptor (RyR) channels, requires physiological ROS levels that are mainly sustained by the NADPH oxidase (NOX) complex.	ros	134-137	ryanodine receptor 2	Rattus norvegicus	76-94
19415690-10	2009	Further assays showed that higher degrees of ROS generation and Akt signaling pathway activation in LNCaP-uMtCK than in LNCaP-neo cells.	ros	45-48	creatine kinase, mitochondrial 1B	Homo sapiens	106-111
19415690-12	2009	Exogenous uMtCK in LNCaP cells surprisingly contributed to overproduction of ROS, activation of Akt signaling pathway and more aggressive phenotypes including androgen independence development.	ros	77-80	creatine kinase, mitochondrial 1B	Homo sapiens	10-15
27798190-3	2016	Ca2+ release from the endoplasmic reticulum, mediated by both the IP3R1 and ryanodine receptor (RyR) channels, requires physiological ROS levels that are mainly sustained by the NADPH oxidase (NOX) complex.	ros	134-137	ryanodine receptor 2	Rattus norvegicus	96-99
25220386-5	2014	Using the MnSOD as an oxidative stress marker, we showed here that ALA treatment of cultured cells induced ROS production, increasing with ALA concentration.	ros	107-110	superoxide dismutase 2	Homo sapiens	10-15
19451660-3	2009	Manganese superoxide dismutase (MnSOD) is one important repair enzyme for reactive oxidative stress (ROS)-induced damage.	ros	101-104	superoxide dismutase 2	Homo sapiens	0-30
27798190-10	2016	Our work suggests that NOX-derived ROS promote axonal growth by regulating Rac1 activity, a molecular determinant of axonal growth, through a ryanodine receptor (RyR)-mediated Ca2+ release mechanism.	ros	35-38	Rac family small GTPase 1	Rattus norvegicus	75-79
19451660-3	2009	Manganese superoxide dismutase (MnSOD) is one important repair enzyme for reactive oxidative stress (ROS)-induced damage.	ros	101-104	superoxide dismutase 2	Homo sapiens	32-37
27798190-10	2016	Our work suggests that NOX-derived ROS promote axonal growth by regulating Rac1 activity, a molecular determinant of axonal growth, through a ryanodine receptor (RyR)-mediated Ca2+ release mechanism.	ros	35-38	ryanodine receptor 2	Rattus norvegicus	142-160
27798190-10	2016	Our work suggests that NOX-derived ROS promote axonal growth by regulating Rac1 activity, a molecular determinant of axonal growth, through a ryanodine receptor (RyR)-mediated Ca2+ release mechanism.	ros	35-38	ryanodine receptor 2	Rattus norvegicus	162-165
25152235-1	2014	15(S)-Hydroxyeicosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1/2 (15-LO1/2) metabolite of arachidonic acid (AA), induces CD36 expression through xanthine oxidase and NADPH oxidase-dependent ROS production and Syk and Pyk2-dependent STAT1 activation.	ros	204-207	PTK2 protein tyrosine kinase 2 beta	Mus musculus	231-235
27655718-10	2016	Our results showed that lowering the level of ROS-producing enzyme - NOX4 oxidase below physiological level leads to cellular senescence of VSMCs which is correlated with secretion of pro-inflammatory cytokines.	ros	46-49	NADPH oxidase 4	Homo sapiens	69-73
25034964-6	2014	Meantime, generation of ROS produced during the fibrillation process was inhibited, which was proposed to be the main factor for the hIAPP-cytotoxicity in beta cells.	ros	24-27	islet amyloid polypeptide	Homo sapiens	133-138
19328187-5	2009	We also found that administration of recombinant Vpr (rVpr) to human neurons resulted in a slow but sustained elevation of intracellular calcium [Ca(2+)]i. Interestingly, our data also show that [Ca(2+)]i elevation by Vpr leads to ROS production and impairs glutamate signaling in neuronal cells.	ros	231-234	Vpr	Human immunodeficiency virus 1	49-52
19328187-5	2009	We also found that administration of recombinant Vpr (rVpr) to human neurons resulted in a slow but sustained elevation of intracellular calcium [Ca(2+)]i. Interestingly, our data also show that [Ca(2+)]i elevation by Vpr leads to ROS production and impairs glutamate signaling in neuronal cells.	ros	231-234	Vpr	Human immunodeficiency virus 1	55-58
27585948-6	2016	In this study, we demonstrated that Ca2+/calcineurin-dependent de-phosphorylation of Drp1 induces mitochondrial fission and regulates mitochondrial ROS production, which influences the expression of pro-inflammatory mediators in LPS-induced microglia cells.	ros	148-151	collapsin response mediator protein 1	Homo sapiens	85-89
19333000-3	2009	In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3beta leading to autophagic cell death.	ros	7-10	glycogen synthase kinase 3 beta	Homo sapiens	11-20
19333000-3	2009	In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3beta leading to autophagic cell death.	ros	7-10	glycogen synthase kinase 3 beta	Homo sapiens	129-138
25128810-8	2014	Furthermore, inhibiting the Akt/GSK-3beta and ERK1/2 pathway by these inhibitors significantly reversed the hispidin-induced Bax and Bcl-2 expression, apoptosis induction, and ROS production.	ros	176-179	glycogen synthase kinase 3 beta	Rattus norvegicus	32-41
25128810-8	2014	Furthermore, inhibiting the Akt/GSK-3beta and ERK1/2 pathway by these inhibitors significantly reversed the hispidin-induced Bax and Bcl-2 expression, apoptosis induction, and ROS production.	ros	176-179	mitogen activated protein kinase 3	Rattus norvegicus	46-52
19333000-3	2009	In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3beta leading to autophagic cell death.	ros	56-59	glycogen synthase kinase 3 beta	Homo sapiens	11-20
27554094-3	2016	Insulinotropic glucagon-like peptide-1 (GLP-1) mimetics have potent neuroprotective effects in animal models of neuropathology associated with ROS/RNS dysfunction.	ros	143-146	glucagon	Mus musculus	15-38
19333000-3	2009	In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3beta leading to autophagic cell death.	ros	56-59	glycogen synthase kinase 3 beta	Homo sapiens	129-138
19333000-3	2009	In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3beta leading to autophagic cell death.	ros	56-59	glycogen synthase kinase 3 beta	Homo sapiens	11-20
25522535-6	2014	Treatment of HepG2 cells with flavone for 24 h reduced the accumulation of intracellular ROS, which correlated with upregulation of Gred, CuZnSOD and MnSOD mRNA levels.	ros	89-92	superoxide dismutase 2	Homo sapiens	150-155
19333000-3	2009	In the ROS-GSK-3beta autophagy pathway, cadmium induces ROS most likely from the mitochondria, and the ROS consequently activate GSK-3beta leading to autophagic cell death.	ros	56-59	glycogen synthase kinase 3 beta	Homo sapiens	129-138
27554094-3	2016	Insulinotropic glucagon-like peptide-1 (GLP-1) mimetics have potent neuroprotective effects in animal models of neuropathology associated with ROS/RNS dysfunction.	ros	143-146	glucagon	Mus musculus	40-45
19241441-7	2009	These findings indicate that the inhibitory effects of evodiamine and rutaecarpine on LIGHT-induced migration and the activation of CCR1, CCR2, ICAM-1, ERK, and p38 MAPK occurs via decreased ROS production and NADPH oxidase activation.	ros	191-194	C-C motif chemokine receptor 1	Homo sapiens	132-136
27268964-8	2016	In addition, an increment in the levels of ROS, caspase-8, -9 and -3 was observed.	ros	43-46	caspase 8	Homo sapiens	48-68
18952046-5	2009	mGPDH-dependent ROS production was localized to the dehydrogenase+CoQ and complex III, the latter being the highest in all mitochondria but BAT.	ros	16-19	bile acid-CoA:amino acid N-acyltransferase	Homo sapiens	140-143
18767115-9	2008	Further experiments suggested that XOR derived ROS mediated this effect and also modulated COX-2 and MMP levels and function.	ros	47-50	xanthine dehydrogenase	Homo sapiens	35-38
27539741-5	2016	Further in vivo studies confirmed that AtBAG5 localizes to mitochondria and that its overexpression leads to leaf senescence symptoms including decreased chlorophyll retention and massive ROS production in dark-induced plants.	ros	188-191	BCL-2-associated athanogene 5	Arabidopsis thaliana	39-45
25111187-4	2014	P25 decreased the expression of calnexin protein, an endoplasmic reticulum (ER) membrane marker, and increased the number of cells generating ROS in a dose dependent manner.	ros	142-145	lipocalin 2	Mus musculus	0-3
27554787-8	2016	After 120min, hCG further increased androgenesis in Leydig cells that was sensitive to inhibition of the cAMP/PKA, ERK1/2 and ROS signaling pathways.	ros	126-129	hypertrichosis 2 (generalised, congenital)	Homo sapiens	14-17
25253202-10	2014	Treatment with MC3 resulted in a substantial alteration of the cellular redox homeostasis leading to increased ROS levels and a decrease in the mitochondrial membrane potential.	ros	111-114	melanocortin 3 receptor	Homo sapiens	15-18
18829332-1	2008	we found that 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives 8d, 8e and 8f could effectively induce apoptosis in A549 lung cancer cells and elevate the levels of integrin beta4 and ROS.	ros	211-214	integrin subunit beta 4	Homo sapiens	192-206
27323401-0	2016	Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.	ros	98-101	programmed cell death 4	Homo sapiens	133-138
18593227-0	2008	NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts.	ros	15-18	NADPH oxidase 4	Homo sapiens	0-4
18593227-7	2008	Silencing of NOX4 by siRNA caused reduction of ROS levels under both normoxic and hypoxic (24 h) conditions and suppressed the significant hypoxic-induced ROS increase.	ros	47-50	NADPH oxidase 4	Homo sapiens	13-17
18593227-7	2008	Silencing of NOX4 by siRNA caused reduction of ROS levels under both normoxic and hypoxic (24 h) conditions and suppressed the significant hypoxic-induced ROS increase.	ros	155-158	NADPH oxidase 4	Homo sapiens	13-17
18593227-11	2008	In conclusion, NOX4 maintains ROS levels under normoxic and hypoxic conditions and enhances proliferation and inhibits apoptosis of PAFB.	ros	30-33	NADPH oxidase 4	Homo sapiens	15-19
18467643-4	2008	Nox4 overexpression substantially increased basal ROS generation whereas ROS generation in response to angiotensin II and tumor necrosis factor (TNF)alpha was enhanced in Nox2-overexpressing cells.	ros	50-53	NADPH oxidase 4	Homo sapiens	0-4
24955726-7	2014	In addition, autophagy induced by silencing of EEF2K is attributed to induction of protein synthesis and activation of the AMPK-ULK1 pathway, independent of the suppression of MTOR activity and ROS generation.	ros	194-197	eukaryotic elongation factor 2 kinase	Homo sapiens	47-52
25016361-13	2014	CONCLUSION: The present study demonstrates that Hcy is able to initiate an inflammatory response in VSMCs by stimulating CRP production, which is mediated through NMDAr-ROS-ERK1/2/p38-NF-kappaB signal pathway.	ros	169-172	mitogen activated protein kinase 3	Rattus norvegicus	173-179
26947058-6	2016	Recent works have shown that, at variance from VDAC1, VDAC2 and VDAC3 exhibit cysteines predicted to protrude towards the intermembrane space, making them a preferred target for oxidation by ROS.	ros	191-194	voltage dependent anion channel 2	Homo sapiens	54-59
24945955-8	2014	In contrast, Cyb5R3 inhibitors (6-propyl-2-thiouracil, p-chloromercuriobenzoate, quercetin, mersalyl, and ebselen) showed similar patterns of inhibition of ROS generation and cytochrome c reduction.	ros	156-159	cytochrome b5 reductase 3	Homo sapiens	13-19
18410972-5	2008	Our results demonstrate that BNP regulates the production of major inflammatory molecules, such as reactive oxygen- and nitrogen species (ROS and RNS), leukotriene B(4) (LTB(4)), prostaglandin E(2) (PGE(2)); modulates the cytokines (TNF-alpha, IL-12 and IL-10) profile, and affects cell motility.	ros	138-141	natriuretic peptide B	Homo sapiens	29-32
18348865-5	2008	Thus, the choice between modification of PLZF by SUMO or ubiquitin was determined by the intracellular level of ROS, which was generated by serum deprivation that inactivated the SUMO-conjugating enzymes Uba2 and Ubc9, and resulted in decrease of sumoylation.	ros	112-115	ubiquitin conjugating enzyme E2 I	Homo sapiens	213-217
27079970-8	2016	Activation of TRPA1 participates in protective neuroimmune interactions at multiple levels, sensing ROS and bacterial products and triggering the release of neuropeptides.	ros	100-103	transient receptor potential cation channel subfamily A member 1	Homo sapiens	14-19
18241674-0	2008	Visfatin enhances ICAM-1 and VCAM-1 expression through ROS-dependent NF-kappaB activation in endothelial cells.	ros	55-58	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
18241674-7	2008	Furthermore, visfatin increased ROS generation, and visfatin-induced CAMs expression and NF-kappaB activation were abrogated in the presence of the direct scavenger of ROS.	ros	32-35	nicotinamide phosphoribosyltransferase	Homo sapiens	13-21
18241674-7	2008	Furthermore, visfatin increased ROS generation, and visfatin-induced CAMs expression and NF-kappaB activation were abrogated in the presence of the direct scavenger of ROS.	ros	168-171	nicotinamide phosphoribosyltransferase	Homo sapiens	13-21
18241674-7	2008	Furthermore, visfatin increased ROS generation, and visfatin-induced CAMs expression and NF-kappaB activation were abrogated in the presence of the direct scavenger of ROS.	ros	168-171	nicotinamide phosphoribosyltransferase	Homo sapiens	52-60
25352950-2	2014	In poor microenvironmental conditions Mirk mediates cell survival by maintaining cancer cells in a largely quiescent, noncycling state and by decreasing toxic ROS levels through maintaining expression of a series of antioxidant genes.	ros	159-162	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	Mus musculus	38-42
25031298-10	2014	ACE2 was negatively correlated with ACE1, angiotensin I, angiotensin II, TGF-beta1, Col-IV, FN, ROS, and MDA, and positively correlated with SOD and GSH (each p &lt; 0.05).	ros	96-99	angiotensin converting enzyme 2	Homo sapiens	0-4
27171858-3	2016	Loss of SLC35D3 in ros (roswell mutant) mice showed a reduction of 11.9% DA neurons in the SNc and 15.5% DA neuron loss in the VTA with impaired autophagy.	ros	19-22	solute carrier family 35, member D3	Mus musculus	8-15
25000557-5	2014	UV-stimulated defence against ROS was strongest in chloroplasts, since activities of plastid enzymes FeSOD and APX had larger relative increases than other, non-plastid specific SODs or peroxidases.	ros	30-33	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	111-114
18241674-8	2008	Taken together, our results demonstrate that visfatin is a vascular inflammatory molecule that increases expression of the inflammatory CAMs, ICAM-1 and VCAM-1, through ROS-dependent NF-kappaB activation in endothelial cells.	ros	169-172	nicotinamide phosphoribosyltransferase	Homo sapiens	45-53
18234561-4	2008	HGF reduced H(2)O(2)-induced loss of viability, diminished H(2)O(2)-mediated ROS generation and abrogated H(2)O(2)-triggered changes in GSH/GSSG ratio.	ros	77-80	hepatocyte growth factor	Homo sapiens	0-3
26819450-12	2016	Inactivation of HIF1/NDUFA4L2 increased mitochondrial activity and oxygen consumption, resulting in ROS accumulation and apoptosis.	ros	100-103	NDUFA4 mitochondrial complex associated like 2	Homo sapiens	21-29
27203679-7	2016	Moreover, we observed that after a complete recovery of BPPV, the ROS concentrations, pro-inflammatory cytokine concentrations and p53 expression levels were attenuated.	ros	66-69	benign paroxysmal positional vertigo	Homo sapiens	56-60
17971295-11	2007	Moreover, we observed that ROS is an important upstream signal for AMPK activation during ginsenoside Rh2 treatment.	ros	27-30	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	67-71
25349781-0	2014	ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma.	ros	0-3	pro-apoptotic WT1 regulator	Homo sapiens	14-43
25349781-0	2014	ROS-dependent prostate apoptosis response-4 (Par-4) up-regulation and ceramide generation are the prime signaling events associated with curcumin-induced autophagic cell death in human malignant glioma.	ros	0-3	pro-apoptotic WT1 regulator	Homo sapiens	45-50
17492052-5	2007	Neutrophils from CalDAG-GEFI(-/-) mice exhibited strong defects in Rap1 and beta(1) and beta(2) integrin activation while maintaining normal calcium flux, degranulation, and ROS generation.	ros	174-177	RAS, guanyl releasing protein 2	Mus musculus	17-28
27005319-11	2016	FoxO1 silencing by siRNA abolished the protective effects of apelin-13 against hypoxia-induced apoptosis and mitochondrial ROS generation.	ros	123-126	apelin	Mus musculus	61-67
17341580-9	2007	Reformation of the mitochondrial tubules by expressing the dominant interfering DRP1 or by RNA silencing of endogenous DRP1 protein rescued both the morphological aberrations and the increased production of ROS induced by downregulation of SENP5.	ros	207-210	collapsin response mediator protein 1	Homo sapiens	80-84
17341580-9	2007	Reformation of the mitochondrial tubules by expressing the dominant interfering DRP1 or by RNA silencing of endogenous DRP1 protein rescued both the morphological aberrations and the increased production of ROS induced by downregulation of SENP5.	ros	207-210	collapsin response mediator protein 1	Homo sapiens	119-123
25349781-5	2014	Curcumin suppresses the growth of human malignant glioma cells via ROS-dependent prostate apoptosis response-4 (Par-4) induction and ceramide generation.	ros	67-70	pro-apoptotic WT1 regulator	Homo sapiens	81-110
25349781-5	2014	Curcumin suppresses the growth of human malignant glioma cells via ROS-dependent prostate apoptosis response-4 (Par-4) induction and ceramide generation.	ros	67-70	pro-apoptotic WT1 regulator	Homo sapiens	112-117
25349781-8	2014	Overall, this study describes a novel signaling pathway by which curcumin induces ROS-dependent Par-4 activation and ceramide generation, leading to autophagic cell death in human malignant glioma cells.	ros	82-85	pro-apoptotic WT1 regulator	Homo sapiens	96-101
26935109-13	2016	POMC-Ptp1b deletion increases plasma TNF-alpha levels, which contribute to body weight regulation via increased energy expenditure and impair endothelial function via COX-2 and ROS-dependent mechanisms.	ros	177-180	pro-opiomelanocortin-alpha	Mus musculus	0-4
27129162-2	2016	System xc-, a cystine-glutamate transporter, which consists of xCT and CD98, influences many ROS-dependent pathways by regulating the production of the antioxidant glutathione.	ros	93-96	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	63-66
25122164-10	2014	The improvement of QSYQ was accompanied with a restoration of angiotensin II-NADPHoxidase-ROS-MMPs pathways.	ros	90-93	matrix metallopeptidase 2	Rattus norvegicus	94-98
17240372-3	2007	Heat production by UCP1 in brown adipocytes is generally a long and adaptive phenomenon, whereas control of mitochondrial ROS by UCP2 needs more subtle regulation.	ros	122-125	uncoupling protein 2	Homo sapiens	129-133
27222705-0	2016	Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway.	ros	101-104	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	105-109
27222705-16	2016	CONCLUSION: Exogenous H2S might protect arterial endothelial cells by suppressing excessive autophagy induced by oxidative stress through the Nrf2-ROS-AMPK signaling pathway.	ros	147-150	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	151-155
27106929-9	2016	In conclusion and as predicted from its proposed role in iron sulfur cluster (ISC) biosynthesis, disruption of frataxin primarily causes impaired function of ISC-containing enzymes, whereas other consequences, including elevated ROS production and iron accumulation, appear secondary.	ros	229-232	frataxin	Homo sapiens	111-119
17376698-4	2006	IFN-alpha2b mediated radical oxygen species (ROS) production that preceded the loss of mitochondrial transmembrane potential (DeltaPsi), release of cytochrome c, and activation of caspase-3.	ros	45-48	caspase 3	Rattus norvegicus	180-189
16814099-10	2006	This plasmid attenuated the ROS formation in mouse VSMC as detected using L012 chemiluminescence and prevented the agonist-induced ROS production in response to basic fibroblast growth factor and epidermal growth factor.	ros	28-31	fibroblast growth factor 2	Mus musculus	161-191
16814099-10	2006	This plasmid attenuated the ROS formation in mouse VSMC as detected using L012 chemiluminescence and prevented the agonist-induced ROS production in response to basic fibroblast growth factor and epidermal growth factor.	ros	131-134	fibroblast growth factor 2	Mus musculus	161-191
16815147-4	2006	However, the effects of PPARgamma on ROS generation in conditions associated with airway inflammation have not been clarified.	ros	37-40	peroxisome proliferator activated receptor gamma	Mus musculus	24-33
24530899-4	2014	Additionally, oxidative activation of CaMKII is suggested in subcellular domains where calcium and ROS signaling intersect, such as mitochondria.	ros	99-102	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	38-44
25084093-5	2014	Our data demonstrate that ginsenoside Rb3 suppresses OGD-Rep-induced cell apoptosis by the suppression of ROS generation.	ros	106-109	stathmin-like 4	Mus musculus	38-41
27173006-9	2016	The results revealed that SARS-CoV PLpro significantly triggered Egr-1 dependent activation of TGF-beta1 promoter via ROS/p38 MAPK/STAT3 pathway, correlating with up-regulation of pro-fibrotic responses in vitro and in vivo.	ros	118-121	transforming growth factor, beta 1	Mus musculus	95-104
16815147-5	2006	OBJECTIVE: This study aimed to investigate the effects of the PPARgamma on ROS generation in allergic airway disease of mice.	ros	75-78	peroxisome proliferator activated receptor gamma	Mus musculus	62-71
16815147-9	2006	CONCLUSION: These results indicate that the effects of PPARgamma are mediated by the modulation of ROS generation and activation of redox-sensitive transcription factor nuclear factor-kappaB and HIF-1alpha in allergic airway disease of mice.	ros	99-102	peroxisome proliferator activated receptor gamma	Mus musculus	55-64
27041464-8	2016	Furthermore, ROS production and the expression of p47 (a key subunit of NADPH oxidase complexes) were increased in a time-dependent manner; the expression of fibronectin, alpha-SMA and TGF-beta were upregulated.	ros	13-16	transforming growth factor, beta 1	Mus musculus	185-193
26966066-4	2016	Here we found that PEDF and 44mer decreased the content of ROS.	ros	59-62	serpin family F member 1	Rattus norvegicus	19-23
16713977-3	2006	Exposure of macrophages to CO alone in vitro produced a brief burst of mitochondrial-derived ROS, which led to expression of PPARgamma.	ros	93-96	peroxisome proliferator activated receptor gamma	Mus musculus	125-134
16713977-5	2006	Blocking the CO-mediated increase in ROS generation prevented PPARgamma induction, and blocking PPARgamma prevented CO"s anti-inflammatory effects.	ros	37-40	peroxisome proliferator activated receptor gamma	Mus musculus	62-71
26835555-9	2016	Moreover, JWH-015 induced the expression of p-PKB and p-FoxO1 protein and decreased the expression of cav-1, which were greatly reversed by ROS inhibitor or PI3K inhibitor.	ros	140-143	forkhead box O1	Rattus norvegicus	56-61
16087477-8	2005	The PAH exposure at workplaces was mainly composed of volatile compounds, particularly naphthalene, suggesting low exposure through the respiratory tract and a low effect of PAH in ROS induction.	ros	181-184	phenylalanine hydroxylase	Homo sapiens	4-7
26967755-5	2016	When activated by peroxisomal ROS, ATM signals to TSC to repress mTORC1 signaling and increase autophagic flux in cells, and also phosphorylates the peroxisomal protein PEX 5 to target peroxisomes for selective autophagy (pexophagy), providing a mechanism for regulation of peroxisomal homeostasis using ROS as a rheostat.	ros	30-33	CREB regulated transcription coactivator 1	Mus musculus	65-71
16087477-8	2005	The PAH exposure at workplaces was mainly composed of volatile compounds, particularly naphthalene, suggesting low exposure through the respiratory tract and a low effect of PAH in ROS induction.	ros	181-184	phenylalanine hydroxylase	Homo sapiens	174-177
15806174-4	2005	Furthermore, activation of p38 MAP kinase by radiation was associated with radiation-induced cell death and ROS production and PKCdelta was an upstream molecule for p38 MAP kinase activation, ROS generation and subsequent caspase-dependent apoptotic events.	ros	192-195	protein kinase C delta	Homo sapiens	127-135
15806174-7	2005	Based on the above data, we suggest that HSP25 downregulates PKCdelta, which is a key molecule for radiation-induced ROS generation and mitochondrial-mediated caspase-dependent apoptotic events.	ros	117-120	protein kinase C delta	Homo sapiens	61-69
26860957-7	2016	Pretreatment of antioxidants caused decrease in the levels of ROS/RNS leads to an increase in the levels of antioxidants, decrease in biomolecules damage, alterations in Akt, ERK1/2, tuberin, upregulation of OGG1, and decrease in 8-OHdG accumulations in DNA.	ros	62-65	mitogen-activated protein kinase 3	Mus musculus	175-181
15591411-2	2005	We therefore measured the activities of the Rho GTPases Rac1, RhoA, and Cdc42 during hypoxia/reoxygenation and correlated them with changes in endothelial permeability, remodeling of the actin cytoskeleton and adherens junctions, and production of ROS.	ros	248-251	cell division cycle 42	Homo sapiens	72-77
26975474-7	2016	We conclude that the mitochondrial thioredoxin system controls the redox state of cyclophilin D which, in turn, may act as a regulator of several processes including ROS production and pro-apoptotic factors release.	ros	166-169	peptidylprolyl isomerase F	Rattus norvegicus	82-95
14660625-11	2004	Heme oxygenase-1 expression was increased in rho(0) cells, and a heme oxygenase-1 inhibitor decreased the induction of MnSOD in rho(0) cells and their resistance against ROS donors.	ros	170-173	superoxide dismutase 2	Homo sapiens	119-124
26895301-1	2016	Previously, we reported that HIV-Tat elicits spermine oxidase (SMO) activity upregulation through NMDA receptor (NMDAR) stimulation in human SH-SY5Y neuroblastoma cells, thus increasing ROS generation, which in turn leads to GSH depletion, oxidative stress, and reduced cell viability.	ros	186-189	tyrosine aminotransferase	Homo sapiens	33-36
26895301-1	2016	Previously, we reported that HIV-Tat elicits spermine oxidase (SMO) activity upregulation through NMDA receptor (NMDAR) stimulation in human SH-SY5Y neuroblastoma cells, thus increasing ROS generation, which in turn leads to GSH depletion, oxidative stress, and reduced cell viability.	ros	186-189	spermine oxidase	Homo sapiens	45-61
26895301-1	2016	Previously, we reported that HIV-Tat elicits spermine oxidase (SMO) activity upregulation through NMDA receptor (NMDAR) stimulation in human SH-SY5Y neuroblastoma cells, thus increasing ROS generation, which in turn leads to GSH depletion, oxidative stress, and reduced cell viability.	ros	186-189	spermine oxidase	Homo sapiens	63-66
12898525-0	2003	Effect of overexpressing fibroblast growth factor 2 protein isoforms in osteoblastic ROS 17/2.8 cells.	ros	85-88	fibroblast growth factor 2	Rattus norvegicus	25-51
27072166-3	2016	Indeed, ROS, generated during physical activity, are likely main mediators of antioxidant molecules upregulation, as reflected by increased glutathione reductase levels after exercise training.	ros	8-11	glutathione-disulfide reductase	Homo sapiens	140-161
12782417-0	2003	Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid.	ros	91-94	mitogen-activated protein kinase 14	Mus musculus	39-47
27563337-3	2016	IRE1-JNK and eIF2alpha-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors.	ros	118-121	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	0-4
26850078-0	2016	Exposure to a 50-Hz magnetic field induced mitochondrial permeability transition through the ROS/GSK-3beta signaling pathway.	ros	93-96	glycogen synthase kinase 3 beta	Homo sapiens	97-106
26111538-9	2016	These results suggest that upregulation of SOD-2 in Met-5A cells exposed to MWCNTs is mediated by ROS formation and ERK1/2 activation.	ros	98-101	superoxide dismutase 2	Homo sapiens	43-48
27525052-6	2016	In addition, we observed that MeHg induced ROS production in a dose-dependent manner in hNPCs cells, which was associated with significantly increased expressions of ND1, Cytb, and ATP6.	ros	43-46	mitochondrially encoded ATP synthase 6	Homo sapiens	181-185
12643543-10	2003	Study of the binding of wild-type recoverin to ROS membranes showed a zinc-dependent increase of its affinity for the membranes, without regard to calcium content, suggesting further solvation of a protein myristoyl group upon Zn2+ binding.	ros	47-50	recoverin	Homo sapiens	34-43
26683708-8	2015	Furthermore, ROS was generated by pneumococcal infection and inhibited caspase-1 activation within 4 h of infection.	ros	13-16	caspase 1	Mus musculus	71-80
11799110-4	2002	Parallel and downstream components of PI3K signaling such as the Rho family GTPases (Rac, Rho, Cdc42) and the survival factor Akt were all shown to contribute to Ros-induced anchorage-independent growth, although Rac appeared to be less important for Ros-induced colony formation in NIH3T3 cells.	ros	162-165	cell division cycle 42	Mus musculus	95-100
11526541-3	2001	TGF-beta1 mediates radical oxygen species (ROS) production that precedes bcl-xL down-regulation, loss of mitochondrial transmembrane potential, release of cytochrome c, and activation of caspase-3 (Herrera et al., FASEB J 2001;15:741-751).	ros	43-46	Bcl2-like 1	Rattus norvegicus	73-79
11526541-3	2001	TGF-beta1 mediates radical oxygen species (ROS) production that precedes bcl-xL down-regulation, loss of mitochondrial transmembrane potential, release of cytochrome c, and activation of caspase-3 (Herrera et al., FASEB J 2001;15:741-751).	ros	43-46	caspase 3	Rattus norvegicus	187-196
26683708-9	2015	However, in the late phase of infection, IL-1beta secretion and caspase-1-dependent cell death were induced by ROS.	ros	111-114	caspase 1	Mus musculus	64-73
26885153-0	2015	Astragalus polysaccharide improves cardiac function in doxorubicin-induced cardiomyopathy through ROS-p38 signaling.	ros	98-101	mitogen activated protein kinase 14	Rattus norvegicus	102-105
11197067-6	2000	Incubation of [1 beta-3H]-F6-1,23,25(OH)3D3 for 5 days with pSVL-CYP24(+)- transfected ROS 17/2.8 cells generated a metabolite that co-migrated with authentic F6-23-oxo-1,25(OH)2D3.	ros	87-90	cytochrome P450, family 24, subfamily a, polypeptide 1	Rattus norvegicus	65-70
25199686-0	2015	Endosulfan induces COX-2 expression via NADPH oxidase and the ROS, MAPK, and Akt pathways.	ros	62-65	cytochrome c oxidase II, mitochondrial	Mus musculus	19-24
10884379-16	2000	Together, our results strongly suggest that after activation of PDE by light/GTP, Pgamma is phosphorylated by Cdk5 and the phosphorylated Pgamma inhibits GTP/Talpha-activated PDE, even in the presence of GTP/Talpha in ROS.	ros	218-221	mitochondrial ribosome associated GTPase 1	Homo sapiens	154-164
25199686-7	2015	Moreover, endosulfan increased production of the ROS and the ROS-producing NAPDH-oxidase (NOX) family oxidases, NOX2, and NOX3.	ros	61-64	cytochrome b-245, beta polypeptide	Mus musculus	112-116
26212201-4	2015	Down-regulated TIGAR protein triggered a drop in reduced-glutathione levels which resulted in sustained ROS, responsible for apoptosis and autophagy.	ros	104-107	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	15-20
10593410-3	1999	We utilized ROS rendered communication deficient either by stable transfection with antisense cDNA to connexin 43 (Cx43), the predominant gap junction protein in bone (RCx16 cells), or by overexpression of Cx45, a gap junction protein not normally expressed in ROS (ROS/Cx45 cells).	ros	12-15	gap junction protein, gamma 1	Rattus norvegicus	270-274
10593410-4	1999	Both RCx16 and ROS/Cx45 cells displayed reduced dye coupling and Cx43 protein expression relative to ROS, control transfectants, and ROS/Cx45tr, ROS cells expressing carboxylterminal truncated Cx45.	ros	15-18	gap junction protein, gamma 1	Rattus norvegicus	137-141
26212201-5	2015	Over-expression and silencing experiments demonstrated the importance of TIGAR in affecting the ROS-dependent anti-cancer effects of resveratrol.	ros	96-99	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	73-78
10606245-6	1999	Overexpression of CDP/cut in ROS 17/2.8 osteosarcoma cells results in repression of OC promoter activity; this repression is abrogated by mutating OC box I. Gel shift immunoassays show that CDP/cut forms a proliferation-specific protein/DNA complex in conjunction with cyclin A and p107, a member of the retinoblastoma protein family of tumor suppressors.	ros	29-32	cut-like homeobox 1	Rattus norvegicus	18-25
26212201-7	2015	Collectively, results unravel the effects of resveratrol on TIGAR in mediating its ROS dependent influence and suggest a better combination therapy of resveratrol and chloroquine for probable cancer treatment.	ros	83-86	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	60-65
10606245-6	1999	Overexpression of CDP/cut in ROS 17/2.8 osteosarcoma cells results in repression of OC promoter activity; this repression is abrogated by mutating OC box I. Gel shift immunoassays show that CDP/cut forms a proliferation-specific protein/DNA complex in conjunction with cyclin A and p107, a member of the retinoblastoma protein family of tumor suppressors.	ros	29-32	cut-like homeobox 1	Rattus norvegicus	18-21
25998538-10	2015	Furthermore, application of alphaB-crystallin/HSPB5 to isolated rat brain mitochondria inhibits ROS generation induced by complex III inhibition with Antimycin A.	ros	96-99	crystallin, alpha B	Rattus norvegicus	28-45
25541281-4	2015	Using a genetically encoded indicator of intracellular redox potential (Grx1-roGFP2) we found that, compared to the soma, dendritic regions exhibited more dramatic fluctuations in redox potential in response to sub-lethal ROS exposure, and existed in a basally more oxidised state.	ros	222-225	glutaredoxin	Homo sapiens	72-76
10491222-2	1999	Similarity of strain-related responses between ROS cells and osteoblasts was established by demonstrating that ROS cells respond to a short single period of strain in their substrate (1000-3500 microepsilon, 600 cycles, 1 Hz) by a similar strain magnitude-related increase in glucose 6-phosphate dehydrogenase activity as rat osteoblasts and osteocytes in explants in situ.	ros	111-114	glucose-6-phosphate dehydrogenase	Rattus norvegicus	276-309
10358067-10	1999	In addition, recombinant human CTGF-L inhibits osteocalcin production in rat osteoblast-like Ros 17/2.8 cells.	ros	93-96	cellular communication network factor 5	Homo sapiens	31-37
9754575-3	1998	We show that RAG-1-/-, TCRbeta-/- , and p56lck-/- mice lack thymocyte ROS formation with epithelial cells, macrophages, or dendritic cells.	ros	70-73	lymphocyte protein tyrosine kinase	Mus musculus	40-46
24265116-1	2014	The pathogenesis of cardiac fibrosis and adverse remodeling is thought to involve the ROS-dependent induction of inflammatory cytokines and matrix metalloproteinases (MMPs), and the activation and migration of cardiac fibroblasts (CF).	ros	86-89	matrix metallopeptidase 9	Mus musculus	167-171
26294429-0	2015	GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.	ros	43-46	glucagon like peptide 1 receptor	Homo sapiens	0-5
24962785-13	2014	Moreover, MRBE-induced cyclin D1 down-regulation was mediated from cyclin D1 proteasomal degradation, which was dependent on ROS.	ros	125-128	cyclin D1	Homo sapiens	23-32
24962785-13	2014	Moreover, MRBE-induced cyclin D1 down-regulation was mediated from cyclin D1 proteasomal degradation, which was dependent on ROS.	ros	125-128	cyclin D1	Homo sapiens	67-76
24792722-8	2014	These results suggest that betaPix phosphorylation at Ser-340 upregulates Nox1 through Rac activation, confirming Rac as a trigger for acute Nox1-dependent ROS production.	ros	156-159	NADPH oxidase 1	Homo sapiens	141-145
8641188-4	1996	Conditioned medium produced a dose-dependent severalfold increase in ROS cell cAMP that could be blocked by the PTHrP receptor antagonist [Asn10,Leu11,DTrp12]PTHrP-(7-34).	ros	69-72	parathyroid hormone like hormone	Homo sapiens	112-117
8641188-4	1996	Conditioned medium produced a dose-dependent severalfold increase in ROS cell cAMP that could be blocked by the PTHrP receptor antagonist [Asn10,Leu11,DTrp12]PTHrP-(7-34).	ros	69-72	parathyroid hormone like hormone	Homo sapiens	158-163
8641188-6	1996	Furthermore, these antisera were found to inhibit the ability of PTHrP-(1-34) to stimulate ROS cell cAMP production.	ros	91-94	parathyroid hormone like hormone	Homo sapiens	65-70
26294429-0	2015	GLP-1 Cleavage Product Reverses Persistent ROS Generation After Transient Hyperglycemia by Disrupting an ROS-Generating Feedback Loop.	ros	105-108	glucagon like peptide 1 receptor	Homo sapiens	0-5
24885580-0	2014	Visfatin induces MUC8 and MUC5B expression via p38 MAPK/ROS/NF-kappaB in human airway epithelial cells.	ros	56-59	nicotinamide phosphoribosyltransferase	Homo sapiens	0-8
26294429-4	2015	Feedback loop disruption by the GLP-1 cleavage product GLP-1(9-36)(amide) reverses the persistent left shift, thereby normalizing persistent overproduction of ROS and its pathophysiologic consequences.	ros	159-162	glucagon like peptide 1 receptor	Homo sapiens	32-37
24885580-6	2014	Treatment with SB203580 (p38 MAPK inhibitor) and knockdown of p38 MAPK by siRNA significantly blocked visfatin-induced MUC8 and MUC5B expression.Visfatin significantly increased ROS formation.	ros	178-181	nicotinamide phosphoribosyltransferase	Homo sapiens	102-110
24885580-6	2014	Treatment with SB203580 (p38 MAPK inhibitor) and knockdown of p38 MAPK by siRNA significantly blocked visfatin-induced MUC8 and MUC5B expression.Visfatin significantly increased ROS formation.	ros	178-181	nicotinamide phosphoribosyltransferase	Homo sapiens	145-153
24885580-7	2014	Treatment with SB203580 significantly attenuated visfatin-induced ROS formation.	ros	66-69	nicotinamide phosphoribosyltransferase	Homo sapiens	49-57
24885580-8	2014	Treatment with NAC (ROS scavenger) and DPI (NADPH oxidase inhibitor) significantly attenuated visfatin-induced MUC8 and MUC5B expression.	ros	20-23	nicotinamide phosphoribosyltransferase	Homo sapiens	94-102
8673866-2	1995	The metabolically 32P-labelings of both serines and threonines in vitro in osteopontin immunoprecipitated from rat osteoblast-like ROS 17/2.8 cells may suggest that casein kinase II catalyzes this modification.	ros	131-134	secreted phosphoprotein 1	Rattus norvegicus	75-86
26294429-4	2015	Feedback loop disruption by the GLP-1 cleavage product GLP-1(9-36)(amide) reverses the persistent left shift, thereby normalizing persistent overproduction of ROS and its pathophysiologic consequences.	ros	159-162	glucagon like peptide 1 receptor	Homo sapiens	55-60
26232188-10	2015	In TAM-treated cells, ERbeta-overexpression led to less cell viability by an increment in autophagy; and the partial knockdown of ERbeta in T47D triggered an increase in ROS production and apoptosis, leading to cell death.	ros	170-173	estrogen receptor 2	Homo sapiens	130-136
7667104-9	1995	We further showed that overexpression of calreticulin in the rat osteoblast-like cell line (ROS 17/2.8) inhibited the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] responsive transcriptional activation of a vitamin D-sensitive reporter gene, whereas the response to forskolin stimulation of a control promoter-reporter construct containing a cAMP response element (CRE), but no vitamin D response element (VDRE), was not affected by overexpression of calreticulin.	ros	92-95	calreticulin	Rattus norvegicus	41-53
7667104-9	1995	We further showed that overexpression of calreticulin in the rat osteoblast-like cell line (ROS 17/2.8) inhibited the 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] responsive transcriptional activation of a vitamin D-sensitive reporter gene, whereas the response to forskolin stimulation of a control promoter-reporter construct containing a cAMP response element (CRE), but no vitamin D response element (VDRE), was not affected by overexpression of calreticulin.	ros	92-95	calreticulin	Rattus norvegicus	444-456
26314500-2	2015	Here we report that Arabidopsis plants overexpressing YUC6 display enhanced IAA-related phenotypes and exhibit improved drought stress tolerance, low rate of water loss and controlled ROS accumulation under drought and oxidative stresses.	ros	184-187	Flavin-binding monooxygenase family protein	Arabidopsis thaliana	54-58
24885580-8	2014	Treatment with NAC (ROS scavenger) and DPI (NADPH oxidase inhibitor) significantly attenuated visfatin-induced MUC8 and MUC5B expression.	ros	20-23	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	120-125
25944722-12	2015	The ROS formation was inhibited by nitric oxide synthase (NOS) inhibitor L-NAME in both types of neurons, however the mitochondrial complex-I inhibitor rotenone suppressed the ROS formation only in motor neurons.	ros	4-7	nitric oxide synthase 1	Homo sapiens	35-56
24813612-1	2014	The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6 is mediated by mitochondrial ROS (mtROS) signaling.	ros	120-123	Cytochrome b-c1 complex subunit Rieske, mitochondrial	Caenorhabditis elegans	75-80
24681637-9	2014	Furthermore, we observed higher levels of ROS in Atg7-deficient cells, as measured by hydroethidine oxidation.	ros	42-45	autophagy related 7	Homo sapiens	49-53
21153232-4	1995	The levels of PTN mRNA in these cells was significantly reduced by treatment with 10(-8) M: 1alpha,25-dihydroxyvitamin D(3) (1,25(OH)(2)D(3)) for 24 h. However, PTN mRNA levels were increased when the non-osteoblastic cell line, ROS 25/1, was treated with 1,25(OH)(2)D(3).	ros	229-232	pleiotrophin	Rattus norvegicus	14-17
25944722-13	2015	It appears that activation of cytoplasmic nNOS leads to ROS formation in both types of spinal neurons but mitochondria is the major source of ROS in motor neurons.	ros	56-59	nitric oxide synthase 1	Homo sapiens	42-46
7963580-5	1994	Expression of this Ag, designated as Kat1 Ag, was markedly stimulated by a factor secreted by the osteoblastic cell line ROS 17/2.8.	ros	121-124	kynurenine aminotransferase 1	Rattus norvegicus	37-41
25944722-13	2015	It appears that activation of cytoplasmic nNOS leads to ROS formation in both types of spinal neurons but mitochondria is the major source of ROS in motor neurons.	ros	142-145	nitric oxide synthase 1	Homo sapiens	42-46
26166436-11	2015	C/EBPbeta knockdown and beta-catenin activation could significantly promote the invasion of HTR8/SVneo cells, enhance the outgrowth and migration in villous explants and inhibit the excessive generation of intracellular ROS.	ros	220-223	CCAAT enhancer binding protein beta	Homo sapiens	0-9
7970722-7	1994	In NIH3T3 cells, this trk/c-ros hybrid induces growth, a fusiform cell shape, and loss of contact inhibition of growth.	ros	28-31	neurotrophic tyrosine kinase, receptor, type 3	Mus musculus	22-27
26073944-5	2015	We linked ROS production and induction of the mitochondrial permeability transition pore (MPTP) via cyclophilin D and p53 as mechanisms of EPHOSS.	ros	10-13	peptidylprolyl isomerase D	Homo sapiens	100-113
25112514-10	2015	Additionally, hIAPP-induced accumulation of ROS and superoxide was suppressed by co-treatment with Se-SE.	ros	44-47	islet amyloid polypeptide	Homo sapiens	14-19
8456584-5	1993	Maximal ROS 17/2.8 attachment to OP was &gt; or = Col I but required approximately 2.5 times more substrate.	ros	8-11	secreted phosphoprotein 1	Rattus norvegicus	33-35
1617498-2	1992	We have partially isolated them from supernatants of PTH-stimulated ROS 17.2 cells using affinity chromatography.	ros	68-71	parathyroid hormone	Mus musculus	53-56
1617498-10	1992	Similarly, using sucrose density gradient analysis, it is necessary to use three antibodies to bind all the 35S-labeled protein from supernatants of PTH-stimulated ROS cultures (equivalent to the fraction used as immunogen in the mice).	ros	164-167	parathyroid hormone	Mus musculus	149-152
1660566-3	1991	These two operons are regulated positively by the product of virG and negatively by the product of the chromosomal gene ros, which encodes a 15.5 kDa repressor.	ros	120-123	two-component response regulator VirG	Agrobacterium tumefaciens	61-65
24625085-15	2014	CONCLUSIONS: The gold (I) N-heterocyclic carbene complex (C22H26N6AuO2PF6) designated as complex 3 induced ROS and p53 dependent apoptosis in B16F10 cells involving the mitochondrial death pathway along with suppression of melanoma tumor growth by regulating the levels of pro and anti apoptotic factors (p53, p21, NF-kappaB, VEGF and MMP-9).	ros	107-110	matrix metallopeptidase 9	Mus musculus	335-340
24084378-7	2014	CSF1 down-regulated cell surface expression of the CSF1R detected with ROS-AV170, but the antibody did not block CSF1 signalling.	ros	71-74	colony stimulating factor 1	Gallus gallus	0-4
26106522-6	2015	These results show that HA might contribute to ROS reduction through Nrf2 regulation by activating Akt.	ros	47-50	AKT serine/threonine kinase 1	Bos taurus	99-102
24084378-7	2014	CSF1 down-regulated cell surface expression of the CSF1R detected with ROS-AV170, but the antibody did not block CSF1 signalling.	ros	71-74	colony stimulating factor 1	Gallus gallus	51-55
24084378-7	2014	CSF1 down-regulated cell surface expression of the CSF1R detected with ROS-AV170, but the antibody did not block CSF1 signalling.	ros	71-74	colony stimulating factor 1	Gallus gallus	51-55
25862497-7	2015	Results indicate that both AtVDAC3 and AtTrx m2 are involved in ROS signaling and play opposite roles in NaCl stress response.	ros	64-67	voltage dependent anion channel 3	Arabidopsis thaliana	27-34
25891083-7	2015	Mitochondrial membrane potential (DeltaPsim) was detected with JC-1 staining under a fluorescence microscope and quantified by fluorescence ratio detection.Overexpression of appoptosin in SH-SY5Y cells markedly increased cell apoptosis accompanied by reduced HO-1 expression, increased intracellular heme level, ROS overproduction and DeltaPsim impairment.	ros	312-315	solute carrier family 25 member 38	Homo sapiens	174-184
24382354-5	2014	Overexpression of ABCB8, a mitochondrial protein that facilitates iron export, in vitro and in the hearts of transgenic mice decreased mitochondrial iron and cellular ROS and protected against doxorubicin-induced cardiomyopathy.	ros	167-170	ATP-binding cassette, sub-family B (MDR/TAP), member 8	Mus musculus	18-23
25891083-10	2015	RESULTS: Overexpression of appoptosin in SH-SY5Y cells markedly increased cell apoptosis accompanied by reduced HO-1 expression, increased intracellular heme level, ROS overproduction and DeltaPsim impairment.	ros	165-168	solute carrier family 25 member 38	Homo sapiens	27-37
24419424-10	2014	Moreover, LKB1 genetic alterations are concurrent with EGFR, KRAS, HER2, and CD74-ROS fusions.	ros	82-85	CD74 molecule	Homo sapiens	77-81
1786699-5	1991	TGF alpha potentiated the effects of either bPTH-(1-34) or hPTHrP-(1-34) on the stimulation of adenylate cyclase in osteoblast-like ROS 17/2.8 cells.	ros	132-135	parathyroid hormone like hormone	Homo sapiens	59-65
25891083-13	2015	CONCLUSION: Curcumin inhibits appoptosin-induced apoptosis in SH-SY5Y cells by upregulating the expression of HO-1, reducing the production of intracellular heme and ROS, and preventing the DeltaPsim loss.	ros	166-169	solute carrier family 25 member 38	Homo sapiens	30-40
24898407-6	2015	The antioxidant ability in plasma and heart tissues which was detected by the ferric reducing/antioxidant power assay was also decreased with the increased ROS production under humid heat stress, as was the expression of antioxidant genes (SOD2, HO-1, GPx).	ros	156-159	peroxiredoxin 6 pseudogene 2	Mus musculus	252-255
26191173-6	2015	The mechanism might rely on TIGAR over-expression induced ROS scavenging and NADPH increasing.	ros	58-61	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	28-33
1840380-6	1991	M-ROS were enriched in CD4-CD8- thymocytes and had a reduced content of thymocytes expressing high TcR-CD3 levels; they nevertheless contained some mature thymocytes, but only of the CD4+CD8-CD3++ category.	ros	2-5	CD3 antigen, epsilon polypeptide	Mus musculus	103-106
1840380-6	1991	M-ROS were enriched in CD4-CD8- thymocytes and had a reduced content of thymocytes expressing high TcR-CD3 levels; they nevertheless contained some mature thymocytes, but only of the CD4+CD8-CD3++ category.	ros	2-5	CD3 antigen, epsilon polypeptide	Mus musculus	191-194
1840380-9	1991	The CD4+CD8+CD3++ subpopulation, believed to be a developmental intermediate between cortical thymocytes and mature T cells, was present in both ROS populations.	ros	145-148	CD3 antigen, epsilon polypeptide	Mus musculus	12-15
24226522-0	2014	ROS dependence of cyclooxygenase-2 induction in rats subjected to unilateral ureteral obstruction.	ros	0-3	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	18-34
24226522-3	2014	We investigated, both in vivo and in vitro, the role of ROS in the induction of COX-2 in rats subjected to UUO and in RMICs exposed to oxidative and mechanical stress.	ros	56-59	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	80-85
25652229-15	2015	IRP-1 protein levels are not regulated by ROS, but IRP-1-dependent ferritin expression may decrease ROS and increase total glutathione levels, suggesting that ferritin levels are more important than citrate metabolism in protecting renal cells against iron.	ros	100-103	aconitase 1	Rattus norvegicus	51-56
23986550-11	2014	PGN, but not LPS, increased ROS production.	ros	28-31	SPG7 matrix AAA peptidase subunit, paraplegin	Homo sapiens	0-3
25701356-6	2015	FGF21 treatment also suppressed D-gal-induced profound elevation of ROS production and oxidative stress, as evidenced by an increase of the MDA level and depletion of the intracellular GSH level in the liver, and restored the activities of antioxidant enzymes SOD, CAT, GSH-Px, and T-AOC.	ros	68-71	fibroblast growth factor 21	Mus musculus	0-5
25298619-5	2014	Increased Nox4 mRNA expression was associated with increased Nox4 protein expression and ROS production.	ros	89-92	NADPH oxidase 4	Homo sapiens	10-14
2188977-0	1990	Replacement of the human insulin receptor transmembrane and cytoplasmic domains by corresponding domains of the oncogene product v-ros leads to accelerated internalization, degradation, and down-regulation.	ros	131-134	insulin receptor	Homo sapiens	25-41
2188977-2	1990	At 37 degrees C, degradation of insulin receptors photoaffinity labeled on the cell surface (440 kDa) was most rapid for the hybrid hIR.ros (t1/2 1.0 +/- 0.1 h), intermediate for the wild-type hIR (t1/2 2.7 +/- 0.5 h), and slowest for the endogenous CHO insulin receptors (t1/2 3.7 +/- 0.7 h).	ros	136-139	interleukin 1 receptor like 1	Homo sapiens	141-149
2188977-2	1990	At 37 degrees C, degradation of insulin receptors photoaffinity labeled on the cell surface (440 kDa) was most rapid for the hybrid hIR.ros (t1/2 1.0 +/- 0.1 h), intermediate for the wild-type hIR (t1/2 2.7 +/- 0.5 h), and slowest for the endogenous CHO insulin receptors (t1/2 3.7 +/- 0.7 h).	ros	136-139	interleukin 1 receptor like 1	Homo sapiens	198-206
2188977-2	1990	At 37 degrees C, degradation of insulin receptors photoaffinity labeled on the cell surface (440 kDa) was most rapid for the hybrid hIR.ros (t1/2 1.0 +/- 0.1 h), intermediate for the wild-type hIR (t1/2 2.7 +/- 0.5 h), and slowest for the endogenous CHO insulin receptors (t1/2 3.7 +/- 0.7 h).	ros	136-139	interleukin 1 receptor like 1	Homo sapiens	273-281
24129846-7	2014	The concomitant increase in superoxide dismutase (EC 1.15.1.1) and ascorbate peroxidase (EC 1.11.1.7) may have alleviated the photoinhibition caused by the increased level of ROS in sense plants.	ros	175-178	peroxidase	Solanum lycopersicum	77-87
25634538-8	2015	DTX treatment also increased PKCbeta phosphorylation levels and NADPH oxidase activity, which resulted in ROS formation.	ros	106-109	protein kinase C beta	Homo sapiens	29-36
25462070-4	2014	The E2/ER-mediated SOD2 up-regulation results in minimized ROS generation, which highly favors healthy cardiovascular function.	ros	59-62	superoxide dismutase 2	Homo sapiens	19-23
23948453-9	2013	Taking into account these new findings it seems reasonable to assume that the inhibitory/carrier FXIII-B subunits can serve as scavengers of ROS.	ros	141-144	coagulation factor XIII B chain	Homo sapiens	97-104
2108798-5	1990	The present study is the first to report that the rate of BGP secretion at times beyond 48 hours declines to that of control cultures despite the continued administration of 1,25(OH)2D3, and that MGP synthesis is induced in ROS 17/2 cells by 48 hours of 1,25(OH)2D3 treatment.	ros	224-227	matrix Gla protein	Homo sapiens	196-199
2108798-8	1990	The MGP synthesized by the 1,25(OH)2D3-treated ROS 17/2 cells was identical to that found in bone by northern blot analysis of message and by western blot analysis of the media antigen.	ros	47-50	matrix Gla protein	Homo sapiens	4-7
27509686-5	2015	This leads to an increase of ROS production which in turn could regulate signaling pathways sensitive to oxidative stress such as gene-encoding matrix metalloproteases MMP1, MMP13 and Adamalysin ADAMTS4.	ros	29-32	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	195-202
33811561-9	2021	Interestingly, by using both IP3R and VDAC inhibitors, a close cause-effect relationship between mitochondrial Ca2+ overload and ROS generation was evidenced.	ros	129-132	inositol 1,4,5-trisphosphate receptor type 3	Homo sapiens	29-33
23991909-8	2013	We conclude that 1) the Ala allele is more frequent in athletes than in controls; and 2) the higher frequency of the Ala allele was noted in both endurance and power athletes compared with that in controls, suggesting that the positive association between the Ala allele and athletic performance may be related to ROS-related angiogenesis, mitochondrial biosynthesis, and muscle hypertrophy, and not to MnSOD aerobic properties.	ros	314-317	superoxide dismutase 2	Homo sapiens	403-408
25815500-0	2015	[Roles of PKCbeta/P66Shc oxidative stress signal pathway in mediating hyperoxia-induced ROS production in alveolar epithelial cells].	ros	88-91	protein kinase C beta	Homo sapiens	10-17
23964117-6	2013	The induction of IP-10 required ERK, JNK, p38 MAPK, PKC, PTK, PI3K, and ROS.	ros	72-75	chemokine (C-X-C motif) ligand 10	Mus musculus	17-22
33816292-0	2021	Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K-AKT Pathway and Activating the AMPK-ROS Pathway.	ros	150-153	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	145-149
33816292-18	2021	Conclusions: Knockdown of ACLY attenuated cisplatin resistance by inhibiting the PI3K-AKT pathway and activating the AMPK-ROS pathway.	ros	122-125	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	117-121
25815500-1	2015	OBJECTIVE: To explore the roles of PKCbeta/P66Shc oxidative stress signal pathway in mediating hyperoxia-induced reactive oxgen species (ROS) production in alveolar epithelial cells (A549) and the protective effects of PKCbeta inhibitor on hyperoxia-induced injuries of alveolar epithelial cells.	ros	137-140	protein kinase C beta	Homo sapiens	35-42
25485904-10	2015	These results suggest that myocyte steatosis amplifies the fibrotic effects of ANG II through mechanisms that involve activation of TGF-beta signaling and increased production of ROS.	ros	179-182	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	79-82
34923383-8	2022	Exposure to BDE47 and BDE209 can lead to the accumulation of ROS in tobacco leaves, but correspondingly, the activities of antioxidant enzymes SOD, POD, CAT, APX and GPX and the up-regulated expression of their coding genes play an important role in preventing excessive oxidative damage.	ros	61-64	L-ascorbate peroxidase 2, cytosolic	Nicotiana tabacum	158-161
24183307-3	2013	In the present study, we used a streptozotocin-induced rat model of diabetic cardiomyopathy and tested a hypothesis that diabetes-related alteration in RyR2 function is related with ROS-induced posttranslational modifications.	ros	182-185	ryanodine receptor 2	Rattus norvegicus	152-156
24140062-0	2013	SIRT5 desuccinylates and activates SOD1 to eliminate ROS.	ros	53-56	sirtuin 5	Homo sapiens	0-5
23836369-9	2015	N-acetylcysteine, an ROS scavenger, inhibited 2-ABP-induced activation of ERK and JNK, the cell death and caspase-3 activity, which suggested that oxidative stress plays a crucial role in apoptosis through activation of caspase-3 in a ROS/JNK-dependent signaling cascade.	ros	21-24	amine oxidase copper containing 1	Homo sapiens	48-51
24140062-5	2013	SOD1-mediated ROS reduction is increased when SIRT5 is co-expressed.	ros	14-17	sirtuin 5	Homo sapiens	46-51
24222129-7	2013	We also found that knockdown of hBVR reverses multidrug resistance in resistant leukemic HL60 cells by a ROS-dependent mechanism.	ros	105-108	biliverdin reductase A	Homo sapiens	32-36
34894372-8	2022	We found that Gal-3 upregulated TLR-4 and MyD88 expression and NADPH oxidase, thereby increasing intracellular ROS in the chondrocytes.	ros	111-114	galectin 3	Homo sapiens	14-19
34923300-7	2022	PRDX6 silencing increased ROS production in senescent cells, decreased their resistance to oxidative stress-induced cell death, and impaired their viability.	ros	26-29	peroxiredoxin 6	Homo sapiens	0-5
34785090-0	2022	Corrigendum to "TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARgamma-SIRT1 feedback loop in human bladder cancer cells" (Cancer Lett.	ros	59-62	peroxisome proliferator activated receptor gamma	Mus musculus	82-91
34963561-4	2022	In addition, DNR induced NOX4-dependent ROS production, leading to the activation of p38 MAPK and inactivation of Akt and ERK.	ros	40-43	NADPH oxidase 4	Homo sapiens	25-29
23891589-0	2013	Induction of miR-21-PDCD4 signaling by UVB in JB6 cells involves ROS-mediated MAPK pathways.	ros	65-68	programmed cell death 4	Homo sapiens	20-25
23836369-9	2015	N-acetylcysteine, an ROS scavenger, inhibited 2-ABP-induced activation of ERK and JNK, the cell death and caspase-3 activity, which suggested that oxidative stress plays a crucial role in apoptosis through activation of caspase-3 in a ROS/JNK-dependent signaling cascade.	ros	235-238	amine oxidase copper containing 1	Homo sapiens	48-51
34863979-5	2022	NOX4-stimulated ROS generation led to JNK-mediated phosphorylation of cytosolic HuR at Ser221, thereby increasing TNF-alpha protein expression by stabilizing TNF-alpha mRNA.	ros	16-19	NADPH oxidase 4	Homo sapiens	0-4
25562318-7	2015	Within the liver, hepatic stromal cells expressed functional VAP-1, and evaluation of cultured cells revealed that sVAP-1 promotes leukocyte migration through catalytic generation of ROS, which depended on VAP-1 enzyme activity.	ros	183-186	synaptosome associated protein 47	Homo sapiens	115-121
34673249-5	2022	ROS accumulation in the bodies further caused the contents of MDA, protein carbonyl and lipofuscin to increase significantly, the mitochondrial membrane potential to be severely damaged, apoptosis to occur, and the apoptosis genes ced-3 and ced-4 to be significantly upregulated.	ros	0-3	Cell death protein 4	Caenorhabditis elegans	241-246
34854954-7	2022	RESULTS: We found that Hp/CagA+ strain infection and pcDNA3.1/CagA vector transfection result in NLRP3 inflammasome activation, generation of intracellular ROS, and increased invasion and migration of gastric cancer cells.	ros	156-159	S100 calcium binding protein A8	Homo sapiens	26-30
34854954-7	2022	RESULTS: We found that Hp/CagA+ strain infection and pcDNA3.1/CagA vector transfection result in NLRP3 inflammasome activation, generation of intracellular ROS, and increased invasion and migration of gastric cancer cells.	ros	156-159	S100 calcium binding protein A8	Homo sapiens	62-66
34670007-8	2022	Transgenic plants overexpressing ALDH3I1 had higher chlorophyll content, photosynthesis rate and proline, and less accumulation of ROS and malondialdehyde compared to the WT, which contributed to stress tolerance in transgenic plants.	ros	131-134	aldehyde dehydrogenase 3I1	Arabidopsis thaliana	33-40
34969963-6	2021	Triacontanol performs as a good scavenger of ROS by accelerating the activity of antioxidant enzymes (SOD, POD, CAT) and compatible solutes (proline, glycinebetaine, phenolic contents), which lead to improved gas exchange attributes and water relations and in that way enhance the calcium and potassium contents or decline the sodium and chloride contents in cucumber leaves.	ros	45-48	superoxide dismutase [Cu-Zn]-like	Cucumis sativus	102-105
34968686-6	2022	We show that activated GPR84 induces Galpha15-dependent ERK activation, increases intracellular Ca2+ and IP3 levels as well as ROS production.	ros	127-130	G protein subunit alpha 15	Homo sapiens	37-45
34939274-8	2022	Lack of FDFT1 resulted in accumulating NAT8 and D-Pantethine to lower ROS level and inhibit colon cancer cell proliferation.	ros	70-73	farnesyl-diphosphate farnesyltransferase 1	Homo sapiens	8-13
34938381-5	2021	However, phosphorylated H2A.X occurs during apoptosis, which is associated with exposure to cold plasma and ROS.	ros	108-111	H2A.X variant histone	Homo sapiens	24-29
34943041-7	2021	Finally, parasite infection carried out in gp91phox knockout mice with inactive NADPH oxidase was associated with decreased levels of peritoneal HO-1+ cells and splenic Tregs, and partially protected mice from the hepatic damage induced by the parasite, revealing the complexity of the molecular mechanisms involving ROS production that participate in the complex pathology induced by this helminth.	ros	317-320	cytochrome b-245, beta polypeptide	Mus musculus	43-51
34861664-4	2022	LOX-1 is one of the main scavenging receptors for ox-LDL and contributes to atherogenesis by inducing overproduction of ROS, increased expression of proinflammatory cytokines, and secretion of cellular adhesion molecules.	ros	120-123	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
34529240-0	2021	The Protective Effects of AT2R Agonist, CGP42112A, Against Angiotensin II-Induced Oxidative Stress and Inflammatory Response in Astrocytes: Role of AT2R/PP2A/NFkappaB/ROS Signaling.	ros	167-170	angiotensin II receptor, type 2	Rattus norvegicus	26-30
34529240-6	2021	Here, we demonstrated that AT2R activation by CGP abrogated Ang II-induced astrocytic activation, by mitigating the ROS production, mitochondrial dysfunction, IkappaB-alpha degradation, NFkappaB nuclear translocation, and release of TNF-alpha in astrocytes.	ros	116-119	angiotensin II receptor, type 2	Rattus norvegicus	27-31
34529240-8	2021	Mechanistically, AT2R via protein phosphatase-2A (PP2A) abrogated the Ang II-induced NFkappaB activation, ROS generation, and subsequent astrocytic activation.	ros	106-109	angiotensin II receptor, type 2	Rattus norvegicus	17-21
34225572-5	2021	Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway.	ros	88-91	sestrin 2	Homo sapiens	25-33
34225572-5	2021	Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway.	ros	88-91	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	126-174
34225572-5	2021	Under hypoxic condition, Sestrin2 plays a protective role by reducing the generation of ROS through various pathways, such as adenosine monophosphatea-ctivated protein kinase (AMPK) / mammalian target of rapamycin (mTOR) pathway and nuclear factor-E2-related factor2 (Nrf2) pathway.	ros	88-91	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	176-180
34843004-5	2021	miR-223 overexpression promoted cell viability, inhibited cell apoptosis, reduced ROS levels, enhanced Superoxide Dismutase (SOD) activity, and decreased malondialdehyde (MDA) content.	ros	82-85	microRNA 223	Homo sapiens	0-7
24205091-9	2013	Production of intracellular ROS, a key regulator of NF-kappaB-induced MMP-9 activity, was almost completely blocked by pretreatment with AE-BCT.	ros	28-31	matrix metallopeptidase 9	Mus musculus	70-75
24136222-0	2013	Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.	ros	50-53	hexokinase 2	Homo sapiens	89-102
23851195-4	2013	Consequently, 2,2",5"-trihydroxychalcone was selected for further study in vitro towards ROS scavenging in L-6 myoblasts and THP-1 human monocytes, where it shows an excellent antioxidant activity in a concentration range lower than that reported by most studies of related molecules.	ros	89-92	transmembrane 4 L six family member 1	Homo sapiens	107-110
23827392-6	2013	We observed that inhibition or knockdown of PKCdelta significantly reduced PQ induced Nox1 transcript and protein levels, ROS generation and subsequent dopaminergic cell death.	ros	122-125	protein kinase C, delta	Rattus norvegicus	44-52
23757405-0	2013	Mitochondrial uncoupling in skeletal muscle by UCP1 augments energy expenditure and glutathione content while mitigating ROS production.	ros	121-124	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	47-51
23720343-6	2013	In contrast, a high concentration of CsA induced apoptosis, which was also attenuated by lovastatin, elevated intracellular ROS via activation of NADPH oxidase, and increased the expression of p47phox.	ros	124-127	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	37-40
23720343-8	2013	These results indicate that both CsA and lovastatin are harmful to principal cells of the distal tubule, but via ROS-dependent and ROS-independent apoptotic pathways, respectively, and that they counteract probably via mobilization of cellular cholesterol levels.	ros	113-116	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	33-36
23720343-8	2013	These results indicate that both CsA and lovastatin are harmful to principal cells of the distal tubule, but via ROS-dependent and ROS-independent apoptotic pathways, respectively, and that they counteract probably via mobilization of cellular cholesterol levels.	ros	131-134	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	33-36
23708739-5	2013	TOP mRNA and protein were also consistently up-regulated by shear, events which could be completely prevented by pre-treatment of cells with either N-acetylcysteine, superoxide dismutase, or catalase, confirming ROS involvement.	ros	212-215	thimet oligopeptidase 1	Homo sapiens	0-3
23597505-12	2013	In conclusion, we have identified a novel regulatory process induced by an oxidative insult whereby the expression of the mitochondrial protein UCP3 is driven by the Nrf2 transcription factor, which decreases ROS production and prevents cell death.	ros	209-212	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	144-148
23733062-6	2013	Significantly, BSK1 physically associates with the PAMP receptor FLS2 (flagellin sensing 2) and is required by FLS2-mediated ROS burst.	ros	125-128	BR-signaling kinase 1	Arabidopsis thaliana	15-19
23733062-6	2013	Significantly, BSK1 physically associates with the PAMP receptor FLS2 (flagellin sensing 2) and is required by FLS2-mediated ROS burst.	ros	125-128	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	65-69
23733062-6	2013	Significantly, BSK1 physically associates with the PAMP receptor FLS2 (flagellin sensing 2) and is required by FLS2-mediated ROS burst.	ros	125-128	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	71-90
23733062-6	2013	Significantly, BSK1 physically associates with the PAMP receptor FLS2 (flagellin sensing 2) and is required by FLS2-mediated ROS burst.	ros	125-128	Leucine-rich receptor-like protein kinase family protein	Arabidopsis thaliana	111-115
23578765-3	2013	Furthermore, we show that inhibiting Hv1 with Zn(2+) results in an increased production of intracellular ROS.	ros	105-108	hydrogen voltage gated channel 1	Homo sapiens	37-40
23747723-8	2013	We conclude that BMP4 contributes to the downregulation of Kv4.3 K(+) channels in pathological cardiac hypertrophy and the underlying mechanism might be through increasing ROS production.	ros	172-175	bone morphogenetic protein 4	Homo sapiens	17-21
23764845-3	2013	Panc1 cells treated with cannabinoids show elevated AMPK activation induced by a ROS-dependent increase of AMP/ATP ratio.	ros	81-84	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	52-56
23764845-4	2013	ROS promote nuclear translocation of GAPDH, which is further amplified by AMPK, thereby attenuating glycolysis.	ros	0-3	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	74-78
23541442-4	2013	IL-18 induced Nox1-dependent ROS generation, TRAF3IP2 expression, and IKK/NF-kappaB and JNK/AP-1 activation.	ros	29-32	NADPH oxidase 1	Homo sapiens	14-18
23431043-0	2013	The carotenoid lutein enhances matrix metalloproteinase-9 production and phagocytosis through intracellular ROS generation and ERK1/2, p38 MAPK, and RARbeta activation in murine macrophages.	ros	108-111	matrix metallopeptidase 9	Mus musculus	31-57
23567907-3	2013	Here we show that Ku80 deletion also decreased resistance to ROS and alkylating agents that typically cause base lesions and single-strand breaks (SSBs).	ros	61-64	X-ray repair cross complementing 5	Homo sapiens	18-22
23688756-13	2013	CONCLUSION: Mechanisms underlying bone marrow damage by iron overload might be through the follows: (1)The increased ROS induced by excessive iron deposition affected the expressions of Caspase-3 and Bcl-2, which caused more BMMNC apoptosis; (2)The abnormal number and ratio of T lymphocytes caused by iron overload aggravated the abnormality of immunity of IRP; (3)Iron overload may increase the damage to erythrocytes and stem cells coated with auto-antibodies.	ros	117-120	Wnt family member 2	Homo sapiens	358-361
23593194-7	2013	In vitro study using purified CD14++ monocytes revealed that elevation in extracellular [Na(+)] could lead to CD14++CD16+ expansion via a ROS dependent manner.	ros	138-141	CD14 molecule	Homo sapiens	30-34
23593194-7	2013	In vitro study using purified CD14++ monocytes revealed that elevation in extracellular [Na(+)] could lead to CD14++CD16+ expansion via a ROS dependent manner.	ros	138-141	CD14 molecule	Homo sapiens	110-114
23131121-9	2013	These findings correlate with transcriptional up-regulation of the ROS detoxifying mechanisms Sirt1 and Pparg, thus linking triheptanoin with improved mitochondrial status.	ros	67-70	peroxisome proliferator activated receptor gamma	Mus musculus	104-109
23054367-7	2013	Conversely, ethanol-induced ROS generation was inhibited if VDR was activated or Ang II was blocked by an angiotensin II type 1 (AT1) receptor blocker (Losartan).	ros	28-31	angiotensin II receptor type 1	Homo sapiens	106-142
22705098-5	2013	The cytoplasmic expression of LMP2 was similar among the renal lesions, being present in 44 of 56 (79%) ROs, 27 of 38 (71%) CHRCCs, and 7 of 7 (100%) CHRCC-EO cases.	ros	104-107	proteasome 20S subunit beta 9	Homo sapiens	30-34
23267072-10	2013	Inhibition of p66(Shc) expression and mitochondrial translocation by aPC normalized mitochondrial ROS production and the mitochondrial membrane potential in glucose-treated podocytes.	ros	98-101	APC regulator of WNT signaling pathway	Homo sapiens	69-72
22903547-1	2013	In a recent study, we showed that eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), two common omega-3 fatty acids, can cause ROS accumulation and subsequently induce caspase-8-dependent apoptosis in human breast cancer cells (Kang et al.	ros	136-139	caspase 8	Homo sapiens	177-186
23241962-3	2013	We describe a novel intestinal epithelial FPR signaling pathway that is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1.	ros	192-195	NADPH oxidase 1	Homo sapiens	228-232
23516464-5	2013	Moreover, the increase in NOX 2 and NOX 4 mRNA levels, NADPH oxidase activity, and ROS levels induced by PRR over-expression was prevented by mitogen activated protein kinase/extracellular signal-regulated kinase 1 and 2 (MAPK/ERK1/2) inhibition, and phosphoinositide 3 kinase/Akt (IP3/Akt) inhibition, indicating that PRR regulates NOX activity and ROS formation in neuro-2A cells through Ang II-independent ERK1/2 and IP3/Akt activation.	ros	350-353	cytochrome b-245, beta polypeptide	Mus musculus	26-31
23516464-8	2013	We showed that PRR-mediated angiotensin II-independent ROS formation is associated with activation of the MAPK/ERK1/2 and PI3/Akt signaling pathways and up-regulation of mRNA level of NOX 2 and NOX4 isoforms in neuronal cells.	ros	55-58	peptidase inhibitor 3	Homo sapiens	122-125
23359639-7	2013	DPP4-deficient cardiomyocytes were found to be resistant to H(2)O(2)-induced cell death via activating AKT signaling, enhancing glucose uptake, preserving catalase activity, diminishing ROS level and proapoptotic signaling.	ros	186-189	dipeptidylpeptidase 4	Rattus norvegicus	0-4
23359639-13	2013	Long term loss of DPP4 activity increased the capability against ROS stress, which was more than GLP-1 dependent pathway.	ros	65-68	dipeptidylpeptidase 4	Rattus norvegicus	18-22
23187810-6	2012	NCF2 knockdown by siRNA results in a significant reduction of ROS production and stimulates cell death, suggesting a protective function of Nox2-generated ROS in cells against apoptosis.	ros	62-65	neutrophil cytosolic factor 2	Homo sapiens	0-4
23187810-6	2012	NCF2 knockdown by siRNA results in a significant reduction of ROS production and stimulates cell death, suggesting a protective function of Nox2-generated ROS in cells against apoptosis.	ros	155-158	neutrophil cytosolic factor 2	Homo sapiens	0-4
23143230-3	2012	AKR1a4 is involved in ascorbate biosynthesis in mice, but has also recently been found to interact with SMAR1, providing a novel mechanism of ROS regulation by ATM.	ros	142-145	aldo-keto reductase family 1, member A1 (aldehyde reductase)	Mus musculus	0-6
34807516-8	2022	Downregulation of TFAM promotes fibroblast activation with upregulation of fibrosis-relevant GO-terms in RNASeq, partially in a ROS-dependent manner.	ros	128-131	transcription factor A, mitochondrial	Mus musculus	18-22
34313010-8	2021	In CT26 cells, IMB-P1 carried similar antitumor activity with increasing ROS level to intact PRDX5.	ros	73-76	peroxiredoxin 5	Mus musculus	93-98
34789285-5	2021	Then, TPP-MLT was encapsulated in dual targeted micelles mediated by TGN peptide (TGNYKALHPHNG) with high affinity for BBB and SHp peptide (CLEVSRKNG) for the glutamate receptor of oxidative stress-damaged neural cells.TGN/SHp/TPP-MLT micelles could effectively scavenge the overproduced ROS to protect neuronal cells from oxidative stress injury during CIS occurrence, as reflected by the improved infarct volume and neurological deficit in CIS model animals.	ros	288-291	nuclear receptor subfamily 0 group B member 2	Homo sapiens	223-226
22659450-0	2012	The oncogenic lung cancer fusion kinase CD74-ROS activates a novel invasiveness pathway through E-Syt1 phosphorylation.	ros	45-48	CD74 molecule	Homo sapiens	40-44
25562318-7	2015	Within the liver, hepatic stromal cells expressed functional VAP-1, and evaluation of cultured cells revealed that sVAP-1 promotes leukocyte migration through catalytic generation of ROS, which depended on VAP-1 enzyme activity.	ros	183-186	amine oxidase copper containing 3	Homo sapiens	116-121
22659450-3	2012	Here, we report that the NSCLC-derived fusion CD74-ROS, which accounts for 30% of all ROS fusion kinases in NSCLC, is an active and oncogenic tyrosine kinase.	ros	51-54	CD74 molecule	Homo sapiens	46-50
22659450-4	2012	We found that CD74-ROS-expressing cells were highly invasive in vitro and metastatic in vivo.	ros	19-22	CD74 molecule	Homo sapiens	14-18
34827149-6	2021	Silencing of SAMMSON expression by siRNA in MCF-7dox cells resulted in a metabolic rewiring with improvement of oxidative metabolism, decreased mitochondrial ROS production, increased mitochondrial replication, transcription and translation and an attenuation of chemoresistance.	ros	158-161	survival associated mitochondrial melanoma specific oncogenic non-coding RNA	Homo sapiens	13-20
22659450-7	2012	Expression of CD74-ROS resulted in the phosphorylation of the extended synaptotagmin-like protein E-Syt1.	ros	19-22	CD74 molecule	Homo sapiens	14-18
22659450-9	2012	Furthermore, expression of CD74-ROS in noninvasive NSCLC cell lines readily conferred invasive properties that paralleled the acquisition of E-Syt1 phosphorylation.	ros	32-35	CD74 molecule	Homo sapiens	27-31
25901929-7	2015	RESULTS: High glucose increased the production of ROS, the activity of NADPH, the apoptosis rate and the expression level of Rho/ROCK in CMECs, while GLP-1 decreased high glucose-induced ROS production, the NADPH activity and the apoptosis rate and the expression level of Rho/ROCK in CMECs, the difference were statistically significant (P&lt;0.05).	ros	187-190	glucagon like peptide 1 receptor	Homo sapiens	150-155
34743684-6	2021	ELOVL6 and ELOVL7 are sensitive to ROS induced depletion of cellular NADPH and insufficient regeneration via the pentose phosphate pathway and mitochondrial fatty acid oxidation.	ros	35-38	ELOVL fatty acid elongase 6	Homo sapiens	0-6
34388483-0	2021	Targeting ROS-AMPK pathway by multiaction Platinum(IV) prodrugs containing hypolipidemic drug bezafibrate.	ros	10-13	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
25591777-6	2015	Using an antisense approach, we show that ketone induced increases in ROS, ICAM-1 expression, and monocyte adhesion in endothelial cells were prevented in NOX4 knockdown cells.	ros	70-73	NADPH oxidase 4	Homo sapiens	155-159
25263579-8	2015	The attenuation of rotenone-induced apoptosis by Alda-1 resulted from decreasing ROS accumulation, reversal of mitochondrial membrane potential depolarization, and inhibition of activation of proteins related to mitochondrial apoptotic pathway.	ros	81-84	aldolase, fructose-bisphosphate A	Homo sapiens	49-53
34805129-4	2021	In particular, strategies that are tumor/bacteria targeted or activatable by the tumor/bacteria microenvironment such as enzyme/pH/reactive oxygen species (ROS) are summarized.	ros	156-159	phenylalanine hydroxylase	Homo sapiens	128-130
22658259-2	2012	Because Nox2-containing NADPH oxidase is a major source of ROS in the vasculature, we investigated its potential role for the modulation of ischemia-induced neovascularization in the context of aging.	ros	59-62	cytochrome b-245, beta polypeptide	Mus musculus	8-12
22248368-4	2012	Neutralization of IL-13 and IL-4 protected hippocampal neurons in vivo against neurotoxicity by inhibiting activation of microglial NADPH oxidase and iNOS, resulting in attenuation of ROS generation and oxidative damage of protein, lipid and DNA.	ros	184-187	interleukin 4	Rattus norvegicus	28-32
22739161-8	2012	It is concluded that GA induced apoptosis of Jurkat cells by activated caspases through activating of ROS-CaMKII-MAPKK-JNK/P38 pathway.	ros	102-105	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	106-112
25415439-1	2015	MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling.	ros	210-213	microRNA 21a	Mus musculus	0-11
22406624-12	2012	The ROS production and alteration of intracellular Ca2+ level induced by down-regulation of TRPV6 might involve the toxic effects, and cell apoptosis induced by Aroclor 1254 exposure is associated with the pro-apoptotic Apaf-1 pathway as well as alteration of Bcl-2/Bax ratio.	ros	4-7	transient receptor potential cation channel, subfamily V, member 6	Mus musculus	92-97
34777698-7	2021	Functionally, we revealed that miR-4454 inhibitor and miR-4454 inhibitor-mediated exosomes could markedly suppress proliferation, migration, invasion, and vascularization and accelerate cycle arrest, apoptosis, and ROS of HepG2 cells.	ros	215-218	microRNA 4454	Homo sapiens	31-39
34777698-7	2021	Functionally, we revealed that miR-4454 inhibitor and miR-4454 inhibitor-mediated exosomes could markedly suppress proliferation, migration, invasion, and vascularization and accelerate cycle arrest, apoptosis, and ROS of HepG2 cells.	ros	215-218	microRNA 4454	Homo sapiens	54-62
25415439-1	2015	MicroRNA-21 (miR-21) contributes to the pathogenesis of fibrogenic diseases in multiple organs, including the kidneys, potentially by silencing metabolic pathways that are critical for cellular ATP generation, ROS production, and inflammatory signaling.	ros	210-213	microRNA 21a	Mus musculus	13-19
34580954-6	2021	Moreover, ELANE cells exhibited impaired proliferation, colony forming, migration, attachment and spreading; and significantly increased ROS formation and apoptosis, corresponding with increased Cyclin D1 and MMP2 levels.	ros	137-140	elastase, neutrophil expressed	Homo sapiens	10-15
22387164-12	2012	In conclusion, our data showed that on the contrary to what was observed in liver mitochondria, CoQ(2) favors mPTP opening and ROS production in heart mitochondria through an opposite effect on respiratory complex I activity.	ros	127-130	coenzyme Q2, polyprenyltransferase	Rattus norvegicus	96-102
25415439-6	2015	Moreover, miR-21 silencing enhanced mitochondrial function, which reduced mitochondrial ROS production and thus preserved tubular functions.	ros	88-91	microRNA 21a	Mus musculus	10-16
25514797-9	2014	Western blot analysis and ROS production assay revealed that LOX- KO mice show significant decrease in Nox2 expression, ROS production and HIF-1alpha expression, the phosphorylation of p38 MAPK and NF-kappaB p65 subunit as well as expression of redox-sensitive vascular cell adhesion molecule-1 (VCAM-1) and LOX-1 itself in ischemic muscles, which is supposed to be required for macrophage infiltration expressing angiogenic factor VEGF.	ros	26-29	lysyl oxidase	Mus musculus	61-64
22366396-0	2012	alpha-Lipoic acid increases tolerance of cardiomyoblasts to glucose/glucose oxidase-induced injury via ROS-dependent ERK1/2 activation.	ros	103-106	mitogen activated protein kinase 3	Rattus norvegicus	117-123
22366396-10	2012	Inhibition of ROS by N-acetylcysteine abrogated LA-induced ERK1/2 activation and cytoprotection.	ros	14-17	mitogen activated protein kinase 3	Rattus norvegicus	59-65
22366396-12	2012	Our results suggest that pretreatment with LA moderately increased ROS production to induce a preconditioning-like effect by ERK1/2 activation thereby increased tolerance of H9c2 cells to DG/GO challenge.	ros	67-70	mitogen activated protein kinase 3	Rattus norvegicus	125-131
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	60-63	jun proto-oncogene	Mus musculus	248-252
22230328-3	2012	However, using whole cell binding assays with [(3)H]-alendronate, herein we demonstrated the presence of saturable, specific and high affinity binding sites in the Cx43-expressing ROS 17/2.8 osteoblastic cells, authentic osteoblasts and MLO-Y4 cells expressing Cx43 or not, as well as in HeLa cells lacking Cx43 expression and ROS 17/2.8 cells pretreated with agents that disassemble Cx channels.	ros	180-183	gap junction protein, alpha 3	Mus musculus	261-265
34609072-7	2021	Flow cytometry was used to verify the effect of SLC7A11 on ROS production.	ros	59-62	solute carrier family 7 (cationic amino acid transporter, y+ system), member 11	Mus musculus	48-55
34620426-6	2021	Overexpression of CIPK14 suppressed Pst DC3000, Pst DC3000 hrcC and flg22 induced generation of ROS and callose deposition.	ros	96-99	serine/threonine protein kinase 1	Arabidopsis thaliana	18-24
34628272-9	2021	Additionally, CTSC-LIN showed significantly reduced ROS generation and increase antioxidant markers.	ros	52-55	cathepsin C	Homo sapiens	14-22
22230328-3	2012	However, using whole cell binding assays with [(3)H]-alendronate, herein we demonstrated the presence of saturable, specific and high affinity binding sites in the Cx43-expressing ROS 17/2.8 osteoblastic cells, authentic osteoblasts and MLO-Y4 cells expressing Cx43 or not, as well as in HeLa cells lacking Cx43 expression and ROS 17/2.8 cells pretreated with agents that disassemble Cx channels.	ros	180-183	gap junction protein alpha 1	Homo sapiens	261-265
25514797-9	2014	Western blot analysis and ROS production assay revealed that LOX- KO mice show significant decrease in Nox2 expression, ROS production and HIF-1alpha expression, the phosphorylation of p38 MAPK and NF-kappaB p65 subunit as well as expression of redox-sensitive vascular cell adhesion molecule-1 (VCAM-1) and LOX-1 itself in ischemic muscles, which is supposed to be required for macrophage infiltration expressing angiogenic factor VEGF.	ros	120-123	lysyl oxidase	Mus musculus	61-64
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	ros	275-278	hexokinase 2	Homo sapiens	223-226
25419901-4	2014	Cellular monitoring of the oxidative stress in the AKR1C3-elevated cells indicated that IR-induced ROS accumulation and the concomitant DNA damage was significantly alleviated, and such protective consequence disappeared upon AKR1C3 knockdown.	ros	99-102	aldo-keto reductase family 1 member C3	Homo sapiens	51-57
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	ros	275-278	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	231-236
34671066-6	2021	In human ADPKD cells, inducing mitochondrial ROS increased ERK1/2 phosphorylation and decreased AMPK phosphorylation, whereas the converse was observed with increased scavenging of ROS in the mitochondria.	ros	45-48	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	96-100
22249831-12	2012	Furthermore, the level of ROS was dramatically decreased in Lyrm1 knockdown adipocytes.	ros	26-29	LYR motif containing 1	Mus musculus	60-65
22249831-13	2012	Knockdown of the Lyrm1 gene in adipocytes resulted in dramatically increased cellular ATP production, mitochondrial membrane potentials and levels Ucp2 mRNA, while ROS levels were significantly decreased.	ros	164-167	LYR motif containing 1	Mus musculus	17-22
22283774-4	2012	Activation of the classic RAS, ACE/Ang II/AT1R, has been strictly related to down regulation of pro-survival genes (Nampt and Sirt3), increase in ROS production and pro-inflammatory cytokines and chemokines release, leading to cell senescence, inflammation and development of autoimmune dysfunctions.	ros	146-149	angiogenin	Homo sapiens	35-38
25419901-4	2014	Cellular monitoring of the oxidative stress in the AKR1C3-elevated cells indicated that IR-induced ROS accumulation and the concomitant DNA damage was significantly alleviated, and such protective consequence disappeared upon AKR1C3 knockdown.	ros	99-102	aldo-keto reductase family 1 member C3	Homo sapiens	226-232
22283774-4	2012	Activation of the classic RAS, ACE/Ang II/AT1R, has been strictly related to down regulation of pro-survival genes (Nampt and Sirt3), increase in ROS production and pro-inflammatory cytokines and chemokines release, leading to cell senescence, inflammation and development of autoimmune dysfunctions.	ros	146-149	angiotensin II receptor type 1	Homo sapiens	42-46
34560818-8	2021	Changes in miR-24 and Prdx6 levels were associated with altered mitochondrial ROS generation, increase in the DNA damage marker: phosphorylated-H2Ax and changes in viability, senescence, and myogenic potential of myogenic progenitors from mice and humans.	ros	78-81	peroxiredoxin 6	Mus musculus	22-27
34560818-10	2021	We propose that downregulation of miR-24 and subsequent upregulation of Prdx6 in muscle of old mice following injury are an adaptive response to aging, to maintain satellite cell viability and myogenic potential through regulation of mitochondrial ROS and DNA damage pathways.	ros	248-251	peroxiredoxin 6	Mus musculus	72-77
21753779-7	2012	Knockdown of either AhR or Nrf2 abolished the inhibitory capacity of KCZ on ROS and IL-8 production.	ros	76-79	aryl hydrocarbon receptor	Homo sapiens	20-23
25419901-5	2014	These findings uncover the potential involvement of AKR1C3 in removal of cellular ROS and explain, at least partially, the acquired radioresistance by AKR1C3 overexpression.	ros	82-85	aldo-keto reductase family 1 member C3	Homo sapiens	52-58
25152235-0	2014	ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.	ros	0-3	PTK2 protein tyrosine kinase 2 beta	Mus musculus	22-26
24863881-6	2014	Rheb has also been suggested to play roles in other cellular pathways including mitophagy and peroxisomal ROS response.	ros	106-109	Ras homolog, mTORC1 binding	Homo sapiens	0-4
22044588-8	2012	Furthermore, the activation of Bnip3 and mitophagy due to p53/TIGAR inhibition were reversed with antioxidant N-acetyl-cysteine, indicating that this adaptive response requires ROS signal.	ros	177-180	BCL2/adenovirus E1B interacting protein 3	Mus musculus	31-36
22141276-3	2011	The concentration of PMNE in semen is correlated significantly not only with semen white blood cell count and seminal plasma ROS level, but also with the levels of other inflammation related cytokines, such as IL-6, IL-8, and TNF-alpha.	ros	125-128	elastase, neutrophil expressed	Homo sapiens	21-25
34599000-0	2021	Correction: YAP Suppresses Lung Squamous Cell Carcinoma Progression via Deregulation of the DNp63-GPX2 Axis and ROS Accumulation.	ros	112-115	Yes1 associated transcriptional regulator	Homo sapiens	12-15
34599149-9	2021	Forced expression of TFAM is able to rescue morphological and functional mitochondrial alterations, ROS production, and cell death induced by ZZW-115 or genetic inhibition of NUPR1.	ros	100-103	transcription factor A, mitochondrial	Mus musculus	21-25
34293554-5	2021	In cells cultured in the absence of glucose, knockout of IDH1 and ME1 decreases NADPH/NADP+ and GSH/GSSG, increases ROS level and facilitates cell necrosis.	ros	116-119	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	66-69
21946064-4	2011	aterf71/hre2 loss-of-function mutants displayed higher sensitivity to osmotic stress such as high salt and mannitol, accumulating higher levels of ROS under high salt treatment.	ros	147-150	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	0-7
25061875-6	2014	Moreover, hFcgammaRIIA ITAMi-signaling reduced ROS and inflammatory cytokine production through inhibition of guanine nucleotide exchange factor VAV-1 and IL-1 receptor-associated kinase 1 (IRAK-1), respectively.	ros	47-50	Fc gamma receptor IIa	Homo sapiens	10-22
21856739-3	2011	Both the general cellular redox state and extracellular ligand-stimulated ROS production can cause PTP oxidation.	ros	74-77	protein tyrosine phosphatase receptor type U	Homo sapiens	99-102
34399087-7	2021	DEX blocked glucose uptake by downregulating GRalpha expression, which reduced GLUT1 and GLUT3 mRNA and protein expression, which, in turn, may have inhibited the PI3K/AKT/mTOR pathway and activated the ROS/AMPK pathway.	ros	203-206	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	207-211
34478853-13	2021	The results indicated that prenatal toxic factor hypoxia resulted in abnormal ETBR activation, which enhanced ET-1-mediated vasoconstriction of pulmonary arteries and pulmonary artery smooth muscle cell proliferation through ETBR/Nox1/4-derived ROS pathway.	ros	245-248	endothelin receptor type B	Rattus norvegicus	78-82
34478853-13	2021	The results indicated that prenatal toxic factor hypoxia resulted in abnormal ETBR activation, which enhanced ET-1-mediated vasoconstriction of pulmonary arteries and pulmonary artery smooth muscle cell proliferation through ETBR/Nox1/4-derived ROS pathway.	ros	245-248	endothelin receptor type B	Rattus norvegicus	225-229
25061875-6	2014	Moreover, hFcgammaRIIA ITAMi-signaling reduced ROS and inflammatory cytokine production through inhibition of guanine nucleotide exchange factor VAV-1 and IL-1 receptor-associated kinase 1 (IRAK-1), respectively.	ros	47-50	vav guanine nucleotide exchange factor 1	Homo sapiens	145-150
34363824-2	2021	In vitro experiments showed that AL1-1 up-regulated immunostimulatory activities in RAW264.7 cells and that it could successfully promote ROS production and phagocytic activity, increase secretion levels of iNOS, and induce the production of considerable amounts of cytokines (TNF-alpha, IL-6, IL-1beta and IL-12).	ros	138-141	ephrin A5	Mus musculus	33-38
25061875-6	2014	Moreover, hFcgammaRIIA ITAMi-signaling reduced ROS and inflammatory cytokine production through inhibition of guanine nucleotide exchange factor VAV-1 and IL-1 receptor-associated kinase 1 (IRAK-1), respectively.	ros	47-50	interleukin 1 receptor associated kinase 1	Homo sapiens	155-188
25061875-6	2014	Moreover, hFcgammaRIIA ITAMi-signaling reduced ROS and inflammatory cytokine production through inhibition of guanine nucleotide exchange factor VAV-1 and IL-1 receptor-associated kinase 1 (IRAK-1), respectively.	ros	47-50	interleukin 1 receptor associated kinase 1	Homo sapiens	190-196
21776018-5	2011	In this study, we show that ROS trigger the inflammatory process in the cochlea by activating signal transducer and activator of transcription-1 (STAT1).	ros	28-31	signal transducer and activator of transcription 1	Rattus norvegicus	94-144
25044461-5	2014	Myocardial intracellular ROS were significantly higher in UT-B null mice than in wild-type mice (p &lt; 0.01), constituting an important cause of oxidative stress injury in the myocardia of UT-B null mice.	ros	25-28	solute carrier family 14 (urea transporter), member 1	Mus musculus	58-62
21776018-5	2011	In this study, we show that ROS trigger the inflammatory process in the cochlea by activating signal transducer and activator of transcription-1 (STAT1).	ros	28-31	signal transducer and activator of transcription 1	Rattus norvegicus	146-151
21776018-6	2011	Activation of STAT1 activation was dependent on ROS generation through NOX3 NADPH oxidase, knockdown of which by siRNA reduced STAT1 activation.	ros	48-51	signal transducer and activator of transcription 1	Rattus norvegicus	14-19
21776018-6	2011	Activation of STAT1 activation was dependent on ROS generation through NOX3 NADPH oxidase, knockdown of which by siRNA reduced STAT1 activation.	ros	48-51	NADPH oxidase 3	Rattus norvegicus	71-75
21776018-6	2011	Activation of STAT1 activation was dependent on ROS generation through NOX3 NADPH oxidase, knockdown of which by siRNA reduced STAT1 activation.	ros	48-51	signal transducer and activator of transcription 1	Rattus norvegicus	127-132
34584017-10	2021	On the other hand, the down-regulation of GPR43 promoted inflammatory reactions in vitro model through the acceleration of ROS-dependently mitochondrial damage by PPARgamma/ Nox1/EBP50/ p47phox/ NLRP3 signal channel.	ros	123-126	NADPH oxidase 1	Mus musculus	174-178
34375309-1	2021	Nox2 is a ROS-generating enzyme, deficiency of which increases suppression by Tregs in vitro and in an in vivo model of cardiac remodelling.	ros	10-13	cytochrome b-245, beta polypeptide	Mus musculus	0-4
25044461-5	2014	Myocardial intracellular ROS were significantly higher in UT-B null mice than in wild-type mice (p &lt; 0.01), constituting an important cause of oxidative stress injury in the myocardia of UT-B null mice.	ros	25-28	solute carrier family 14 (urea transporter), member 1	Mus musculus	190-194
25175743-0	2014	c-Jun N terminal kinase modulates NOX-4 derived ROS production and myofibroblasts differentiation in human breast stromal cells.	ros	48-51	NADPH oxidase 4	Homo sapiens	34-39
21605627-5	2011	Jatrorrhizine also attenuated caspase-3 activation of the downstream cascade following ROS.	ros	87-90	caspase 3	Rattus norvegicus	30-39
25005497-7	2014	AKAP150 inhibition also abrogated high-glucose-induced cardiomyocyte apoptosis (TUNEL staining and annexin V/propidium iodide flow cytometry) and oxidative stress (ROS production, NADPH oxidase activity, and lipid peroxidation).	ros	164-167	A-kinase anchoring protein 5	Rattus norvegicus	0-7
34409981-3	2021	Incidentally, both have Grb2 as a common downstream adapter and NOX4 as a common ROS producing factor.	ros	81-84	NADPH oxidase 4	Homo sapiens	64-68
25005497-10	2014	These results suggest that cardiac AKAP150 positively responds to hyperglycemia and enhances the efficiency of glucotoxicity signaling through a cPKC/p47(phox)/ROS pathway that induces myocardial dysfunction, cardiomyocyte apoptosis, and oxidative stress.	ros	160-163	A-kinase anchoring protein 5	Rattus norvegicus	35-42
20734249-4	2011	After treatment with cyanide and cobalt, female cortical and mesencephalic astrocytes, respectively, revealed an up-regulation of COX IV-2 which was accompanied by increased ROS production and necrotic cell death.	ros	174-177	cytochrome c oxidase subunit 4I2	Homo sapiens	130-138
24709060-5	2014	This conclusion is validated by the increase in SOD and catalase activities as well as by the GSSG/GSH ratio value decrease, in conjunction with the drop of ROS level and the prevention of the ADP protective effect by pyridoxalphosphate-6-azophenyl-2",4"-disulfonic acid (PPADS), a novel functionally selective antagonist of purine receptor; ii) safeguard of the functionality of the mitochondrial adenine nucleotide-1 translocator (ANT-1), which is early impaired during apoptosis.	ros	157-160	solute carrier family 25 member 4	Rattus norvegicus	398-431
20734249-5	2011	In male astrocytes, the ratio of COX IV-1/COX IV-2 was lowest after treatment with cobalt and paralleled by highest levels of ROS production and necrosis.	ros	126-129	cytochrome c oxidase subunit 4I1	Homo sapiens	33-41
20734249-5	2011	In male astrocytes, the ratio of COX IV-1/COX IV-2 was lowest after treatment with cobalt and paralleled by highest levels of ROS production and necrosis.	ros	126-129	cytochrome c oxidase subunit 4I2	Homo sapiens	42-50
34517917-11	2021	Moreover, nesfatin-1 treatment attenuated CoCl2-induced increase in ROS production and mitochondrial dysfunction, decreased mitochondrial membrane potential, Bax/Bcl-2 imbalance, as well as c-caspase-9 and c-caspase-3 levels.	ros	68-71	nucleobindin 2	Rattus norvegicus	10-20
34508588-3	2022	Here we show that constitutive plasma membrane translocation and activation of the GLUT4 glucose transporter, via ROS-dependent AMPKalpha and p38 hyperactivation, occurs in CS, resulting in accelerated glycolysis, and increased fatty acid synthesis and storage as lipid droplets in primary fibroblasts.	ros	114-117	solute carrier family 2 member 4	Homo sapiens	83-88
21640705-5	2011	Furthermore, overexpression of p53R2 reduces intracellular ROS and protects the mitochondrial membrane potential against oxidative stress.	ros	59-62	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	31-36
24709060-5	2014	This conclusion is validated by the increase in SOD and catalase activities as well as by the GSSG/GSH ratio value decrease, in conjunction with the drop of ROS level and the prevention of the ADP protective effect by pyridoxalphosphate-6-azophenyl-2",4"-disulfonic acid (PPADS), a novel functionally selective antagonist of purine receptor; ii) safeguard of the functionality of the mitochondrial adenine nucleotide-1 translocator (ANT-1), which is early impaired during apoptosis.	ros	157-160	solute carrier family 25 member 4	Rattus norvegicus	433-438
21624350-6	2011	Moreover, when the free radical (ROS) generating capacity of the compounds was studied by 2",7"-dichlorofluorescein-diacetate assay using flow cytometry, we found that a known antioxidant N-acetyl-cysteine almost completely abrogated the H2AX((S139)) phosphorylations and the caspase 3 cleavage and activation.	ros	33-36	H2A.X variant histone	Homo sapiens	238-242
34494551-7	2021	In vitro, human liver S9-derived XOR promoted proliferation of SMCs with phenotypic modulation and induced ROS production by catabolizing hypoxanthine released from human endothelial cells.	ros	107-110	xanthine dehydrogenase	Homo sapiens	33-36
24944625-10	2014	The observations indicated that atorvastatin upregulated LPS induced expression of TIPE2 and consequently inhibited MIF, NF-kappaB, NOS and COX-2 expression and the production of NO, PGE2, TNF-alpha and IL-6, increased HO-1 expression, and inhibited ROS activity in cultured RAW264.7 cells.	ros	250-253	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	83-88
34557417-0	2021	Corrigendum: Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K-AKT Pathway and Activating the AMPK-ROS Pathway.	ros	163-166	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	158-162
24762438-7	2014	We revealed that loss of FLCN constitutively activates AMPK, resulting in PGC-1alpha-mediated mitochondrial biogenesis and increased ROS production.	ros	133-136	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	55-59
34157442-11	2021	Inhibition of mTORC1 led to the downregulation of GPX4 which promoted Lap induced ferroptosis as evidenced by increase of ROS, MDA, Fe 2+ and decrease of GSH.	ros	122-125	CREB regulated transcription coactivator 1	Mus musculus	14-20
21367916-3	2011	In this study, we examined the hypothesis that ANG-(1-7) attenuates ANG II-induced reactive oxygen species stress (ROS)-mediated injury in type 2 diabetic nephropathy of KK-A(y)/Ta mice.	ros	115-118	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	47-55
21367916-7	2011	ANG-(1-7) attenuated ANG II-mediated NAD(P)H oxidase activation and ROS production in diabetic glomeruli and mesangial cells.	ros	68-71	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	0-8
21367916-7	2011	ANG-(1-7) attenuated ANG II-mediated NAD(P)H oxidase activation and ROS production in diabetic glomeruli and mesangial cells.	ros	68-71	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	0-3
21367916-9	2011	These findings were related to improved mesangial expansion and to fibronectin and transforming growth factor-beta1 production in response to ANG II and suggest that ANG-(1-7) may attenuate ANG II-stimulated ROS-mediated injury in type 2 diabetic nephropathy.	ros	208-211	angiogenin, ribonuclease A family, member 5	Mus musculus	166-174
21367916-9	2011	These findings were related to improved mesangial expansion and to fibronectin and transforming growth factor-beta1 production in response to ANG II and suggest that ANG-(1-7) may attenuate ANG II-stimulated ROS-mediated injury in type 2 diabetic nephropathy.	ros	208-211	angiogenin, ribonuclease, RNase A family, 5	Mus musculus	142-145
24762438-8	2014	ROS induced HIF transcriptional activity and drove Warburg metabolic reprogramming, coupling AMPK-dependent mitochondrial biogenesis to HIF-dependent metabolic changes.	ros	0-3	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	93-97
34424529-9	2022	Mechanistically, increased levels of ROS and expression of oxidative stress- and inflammation-related proteins were found in PRDX6 siRNA-treated ROEC cells as compared to control cells, implicating that ablation of PRDX6 in the oviduct creates a stress-induced micro-environment detrimental to early embryonic development in oviduct.	ros	37-40	peroxiredoxin 6	Homo sapiens	125-130
24662377-8	2014	The ROS, MDA and GSH accumulation was significantly affected in the mutant gsh1, gr1 and gpx2 after treatment with OTA, which indicated that glutathione metabolism is directly involved in the oxidative stress response of Arabidopsis thaliana subjected to OTA.	ros	4-7	glutathione-disulfide reductase	Arabidopsis thaliana	81-84
34424529-9	2022	Mechanistically, increased levels of ROS and expression of oxidative stress- and inflammation-related proteins were found in PRDX6 siRNA-treated ROEC cells as compared to control cells, implicating that ablation of PRDX6 in the oviduct creates a stress-induced micro-environment detrimental to early embryonic development in oviduct.	ros	37-40	peroxiredoxin 6	Homo sapiens	215-220
21372632-5	2011	Overexpression of ODC in HL-60 parental cells could reduce HDB-induced apoptosis, which leads to loss of mitochondrial membrane potential (Deltapsi(m)), through lessening intracellular ROS.	ros	185-188	ornithine decarboxylase 1	Homo sapiens	18-21
24286320-6	2014	We found that overexpression of TRAP1 leads to a series of mitochondrial aberrations, including increase in basal ROS levels, and decrease in mitochondrial biogenesis, together with a decrease in peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) mRNA levels.	ros	114-117	TNF receptor-associated protein 1	Mus musculus	32-37
20831446-2	2011	In the present study to examine intracellular MIF redox function, exposure of MIF-deficient cardiac fibroblasts to oxidizing conditions resulted in a 2.3-fold increase (p &lt; 0.001) in intracellular ROS that could be significantly reduced by adenoviral-mediated reexpression of recombinant MIF.	ros	200-203	macrophage migration inhibitory factor	Homo sapiens	78-81
24743151-7	2014	Consequently, fatty acid metabolism and ROS production were enhanced, leading to increased AMPK phosphorylation and Ppara and Pgc1a expression.	ros	40-43	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	126-131
21345685-6	2011	N-acetylcysteine (NAC) treatment abolished p38 phosphorylation as well as HO-1 induction caused by SC-1, indicating that ROS are upstream signals of p38 in Nrf2/ARE activation by SC-1.	ros	121-124	mitogen activated protein kinase 14	Rattus norvegicus	149-152
24415791-9	2014	Finally, V-ATPase accumulation on phagosomes was inversely correlated to intraphagosomal ROS production in neutrophils.	ros	89-92	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	9-17
22140445-0	2011	Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.	ros	25-28	early growth response 1	Bos taurus	40-45
24560910-7	2014	Besides, Rg1 (2, 5mg/kg) was able to decrease ROS generation and attenuate the neuronal oxidative damage in the frontal cortex and hippocampus CA1 in mice.	ros	46-49	protein phosphatase 1, regulatory subunit 3A	Mus musculus	9-12
22140445-0	2011	Xanthine oxidase-derived ROS upregulate Egr-1 via ERK1/2 in PA smooth muscle cells; model to test impact of extracellular ROS in chronic hypoxia.	ros	25-28	mitogen-activated protein kinase 3	Bos taurus	50-56
24521670-2	2014	The expression of the ATPase inhibitory factor 1 (IF1) is a strategy used by cancer cells to inhibit the activity of the H(+)-ATP synthase to generate a ROS signal that switches on cellular programs of survival.	ros	153-156	ATP synthase inhibitory factor subunit 1	Homo sapiens	22-48
21175348-9	2011	SOD2 played an important role in the adaptive/delayed radioprotective response by inhibiting the initiation of a superoxide anion-induced ROS cascade leading to enhanced mitochondrial and nuclear damages.	ros	138-141	superoxide dismutase 2	Homo sapiens	0-4
21043471-6	2010	Antibodies to the mitochondrial alternative oxidase (AOX), previously linked to reduced ROS formation from the electron transport chain and salt tolerance in Arabidopsis, also showed a commensurate higher abundance in v. Wyakatchem in both control and salt-treated conditions.	ros	88-91	alternative oxidase 2	Arabidopsis thaliana	32-51
21043471-6	2010	Antibodies to the mitochondrial alternative oxidase (AOX), previously linked to reduced ROS formation from the electron transport chain and salt tolerance in Arabidopsis, also showed a commensurate higher abundance in v. Wyakatchem in both control and salt-treated conditions.	ros	88-91	alternative oxidase 2	Arabidopsis thaliana	53-56
24521670-2	2014	The expression of the ATPase inhibitory factor 1 (IF1) is a strategy used by cancer cells to inhibit the activity of the H(+)-ATP synthase to generate a ROS signal that switches on cellular programs of survival.	ros	153-156	ATP synthase inhibitory factor subunit 1	Homo sapiens	50-53
24550737-10	2014	The MetS phenotype is reversible by the administration of D1R agonist to the ros mutant.	ros	77-80	leiomodin 1	Homo sapiens	58-61
24505352-8	2014	The Ity3.1 sublocus controls NADPH oxidase activity and is characterized by decreased ROS production, reduced inflammatory cytokine response and increased bacterial burden, thereby supporting a role for Ncf2 (neutrophil cytosolic factor 2 a subunit of NADPH oxidase) as the gene underlying this sublocus.	ros	86-89	immunity to S. typhimurium 3	Mus musculus	4-8
24296130-6	2014	Moreover, genipin increased production of the ROS and the ROS-producing NAPDH-oxidase (NOX) family oxidases, NOX2 and NOX3.	ros	58-61	cytochrome b-245, beta polypeptide	Mus musculus	109-113
20927647-3	2010	Over-expression of PAR-4 gene was accompanied by aberrant Abeta production followed by ROS generation and subsequent death of neuroblastoma cells used in the present study as a cellular model for neurons.	ros	87-90	Prader Willi/Angelman region RNA 4	Homo sapiens	19-24
24296130-8	2014	These results suggest that the molecular mechanism mediating ROS-dependent COX-2 up-regulation and PGE2 production by genipin involves activation of Akt, MAPKs and AP-1/NF-kappaB.	ros	61-64	prostaglandin-endoperoxide synthase 2	Mus musculus	75-80
24125707-11	2014	These results indicate that ROS is one of downstream targets of ERK1/2, not vice versa.	ros	28-31	mitogen activated protein kinase 3	Rattus norvegicus	64-70
20875851-7	2010	Moreover, the increase in ROS, active caspase-3, and apoptosis caused by rot/oligo was also prevented by PST/PNU.	ros	26-29	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4	Homo sapiens	105-108
21042727-6	2010	In the presence of p53, increased ROS from OXPHOS increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR).	ros	34-37	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	182-229
21042727-6	2010	In the presence of p53, increased ROS from OXPHOS increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR).	ros	34-37	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	231-236
24043260-0	2014	Activation of Rap1 inhibits NADPH oxidase-dependent ROS generation in retinal pigment epithelium and reduces choroidal neovascularization.	ros	52-55	RAS-related protein 1a	Mus musculus	14-18
24043260-3	2014	We hypothesize that Rap1 inhibits NADPH oxidase-generated ROS and thereby reduces CNV formation.	ros	58-61	RAS-related protein 1a	Mus musculus	20-24
24043260-4	2014	Using a murine model of laser-induced CNV, we determined that reduced Rap1 activity in RPE/choroid occurred with CNV formation and that activation of Rap1 by 2"-O-Me-cAMP (8CPT)-reduced laser-induced CNV via inhibiting NADPH oxidase-generated ROS.	ros	243-246	RAS-related protein 1a	Mus musculus	70-74
24043260-4	2014	Using a murine model of laser-induced CNV, we determined that reduced Rap1 activity in RPE/choroid occurred with CNV formation and that activation of Rap1 by 2"-O-Me-cAMP (8CPT)-reduced laser-induced CNV via inhibiting NADPH oxidase-generated ROS.	ros	243-246	RAS-related protein 1a	Mus musculus	150-154
24043260-5	2014	In RPE, inhibition of Rap1 by Rap1 GTPase-activating protein (Rap1GAP) increased ROS generation, whereas activation of Rap1 by 8CPT reduced ROS by interfering with the assembly of NADPH oxidase membrane subunit p22phox with NOX4 or cytoplasmic subunit p47phox.	ros	81-84	RAS-related protein 1a	Mus musculus	22-26
21118526-2	2010	Mitochondrial ROS has been established as a mediator of MMP activity.	ros	14-17	matrix metallopeptidase 2	Homo sapiens	56-59
24043260-5	2014	In RPE, inhibition of Rap1 by Rap1 GTPase-activating protein (Rap1GAP) increased ROS generation, whereas activation of Rap1 by 8CPT reduced ROS by interfering with the assembly of NADPH oxidase membrane subunit p22phox with NOX4 or cytoplasmic subunit p47phox.	ros	81-84	Rap1 GTPase-activating protein	Mus musculus	30-60
20846705-0	2010	PKC-delta mediates TCDD-induced apoptosis of chondrocyte in ROS-dependent manner.	ros	60-63	protein kinase C delta	Homo sapiens	0-9
24043260-5	2014	In RPE, inhibition of Rap1 by Rap1 GTPase-activating protein (Rap1GAP) increased ROS generation, whereas activation of Rap1 by 8CPT reduced ROS by interfering with the assembly of NADPH oxidase membrane subunit p22phox with NOX4 or cytoplasmic subunit p47phox.	ros	81-84	Rap1 GTPase-activating protein	Mus musculus	62-69
20846705-8	2010	These results suggest that the translocation of PKC-delta was mediated by ROS-dependent caspase-3 activity.	ros	74-77	protein kinase C delta	Homo sapiens	48-57
20846705-10	2010	Taken together, this study suggests that ROS generation is an upstream event for TCDD-induced chondrocyte apoptosis and PKC-delta mediates the apoptotic processes through ROS-dependent caspase-3 activation.	ros	171-174	protein kinase C delta	Homo sapiens	120-129
24043260-5	2014	In RPE, inhibition of Rap1 by Rap1 GTPase-activating protein (Rap1GAP) increased ROS generation, whereas activation of Rap1 by 8CPT reduced ROS by interfering with the assembly of NADPH oxidase membrane subunit p22phox with NOX4 or cytoplasmic subunit p47phox.	ros	81-84	RAS-related protein 1a	Mus musculus	30-34
24043260-7	2014	Rap1GAP-induced ROS generation was inhibited by active Rap1a, but not Rap1b, and activation of Rap1a by 8CPT in Rap1b(-/-) mice reduced laser-induced CNV, in correlation with decreased ROS generation in RPE/choroid.	ros	16-19	Rap1 GTPase-activating protein	Mus musculus	0-7
20717118-0	2010	NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration.	ros	15-18	NADPH oxidase 4	Homo sapiens	0-4
24043260-7	2014	Rap1GAP-induced ROS generation was inhibited by active Rap1a, but not Rap1b, and activation of Rap1a by 8CPT in Rap1b(-/-) mice reduced laser-induced CNV, in correlation with decreased ROS generation in RPE/choroid.	ros	16-19	RAS-related protein 1a	Mus musculus	55-60
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	ros	116-119	matrix metallopeptidase 2	Homo sapiens	17-43
24043260-7	2014	Rap1GAP-induced ROS generation was inhibited by active Rap1a, but not Rap1b, and activation of Rap1a by 8CPT in Rap1b(-/-) mice reduced laser-induced CNV, in correlation with decreased ROS generation in RPE/choroid.	ros	185-188	Rap1 GTPase-activating protein	Mus musculus	0-7
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	ros	116-119	matrix metallopeptidase 2	Homo sapiens	45-50
20432471-2	2010	Down-regulation of MMP-2 and MMP-9 in U937 cells was abrogated by abolishment of caffeine-elicited increase in intracellular Ca(2+) concentration and ROS generation.	ros	150-153	matrix metallopeptidase 2	Homo sapiens	19-24
24043260-7	2014	Rap1GAP-induced ROS generation was inhibited by active Rap1a, but not Rap1b, and activation of Rap1a by 8CPT in Rap1b(-/-) mice reduced laser-induced CNV, in correlation with decreased ROS generation in RPE/choroid.	ros	185-188	RAS-related protein 1a	Mus musculus	95-100
25400332-13	2014	Increased MnSOD activity indicates the mitochondrial source of ROS in patients with advanced heart failure.	ros	63-66	superoxide dismutase 2	Homo sapiens	10-15
20697159-7	2010	Mechanistically, CD13 reduced ROS-induced DNA damage after genotoxic chemo/radiation stress and protected cells from apoptosis.	ros	30-33	alanyl aminopeptidase, membrane	Homo sapiens	17-21
24391542-8	2013	In addition, our data and that from other groups suggest that signaling through the NMDA receptor/PKC/NOX2 cascade generates ROS that activate the PI3/mTOR pathway and finally leads to the generation of new oligodendrocytes.	ros	125-128	peptidase inhibitor 3	Homo sapiens	147-150
23886864-0	2013	Vitamin C prevents stress-induced damage on the heart caused by the death of cardiomyocytes, through down-regulation of the excessive production of catecholamine, TNF-alpha, and ROS production in Gulo(-/-)Vit C-Insufficient mice.	ros	178-181	gulonolactone (L-) oxidase	Mus musculus	196-200
20213854-3	2010	K(+) is a key nutrient protecting the cells and this effect depends on the Trk1 uptake system and is associated with reduced ROS production.	ros	125-128	Trk1p	Saccharomyces cerevisiae S288C	75-79
34097996-8	2021	Tumor tissues in PFBL-treated mice showed upregulation of similar mechanism of cell death as observed in isolated PC3 cells i.e., elevation of MAO-A catalytic activity, ROS production accompanied by activation of beta-TrCP-GSK-3beta axis of NRF2 degradation.	ros	169-172	chromobox 8	Mus musculus	114-117
34126197-0	2021	Suppressing effects of Green tea extract and Epigallocatechin-3-gallate (EGCG) on TGF-beta- induced Epithelial-to-mesenchymal transition via ROS/Smad signaling in human cervical cancer cells.	ros	141-144	transforming growth factor alpha	Homo sapiens	82-90
20691059-6	2010	Increases in TRPV1 and ROS, generated by synoviocytes in vitro, were reciprocally blocked by TRPV1 antagonists and the ROS scavenger.	ros	23-26	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-98
34126197-8	2021	The molecular mechanism of green tea extract and EGCG for TGF-beta-induced EMT inhibition interfered with ROS generation and Smad signaling.	ros	106-109	transforming growth factor alpha	Homo sapiens	58-66
24025674-4	2013	In contrast, transient ROS generation was not observed with the parental roGFP2 probe without Grx1, which exhibits slower thiol-disulfide exchange.	ros	23-26	glutaredoxin	Homo sapiens	94-98
34126197-10	2021	CONCLUSION: EGCG and green tea extract suppressed TGF-beta-induced EMT in Hela and SiHa cells, and the underlying molecular mechanism may be related to the ROS generation and Smad signaling pathway.	ros	156-159	transforming growth factor alpha	Homo sapiens	50-58
34175438-4	2021	Our results showed that Tat-PRAS40 effectively transduced into SH-SY5Y cells and inhibited DNA damage, ROS generation, and apoptotic signaling in MPP+-induced SH-SY5Y cells.	ros	103-106	tyrosine aminotransferase	Homo sapiens	24-27
34252538-4	2021	In addition, PGC-1alpha that accumulates in TNF null mice, a major participant of mitochondrial metabolism, downregulated ROS activity and the expressions of M1-specific mRNA.	ros	122-125	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	13-23
20691059-6	2010	Increases in TRPV1 and ROS, generated by synoviocytes in vitro, were reciprocally blocked by TRPV1 antagonists and the ROS scavenger.	ros	119-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
20203069-5	2010	Furthermore, oxLDL rapidly activated the membrane translocation of Rac-1 and p47phox and the subsequent induction of ROS generation, which was suppressed markedly by pretreatment with EGCG or anti-LOX-1 monoclonal antibody.	ros	117-120	oxidized low density lipoprotein receptor 1	Homo sapiens	197-202
20203069-9	2010	These data suggest that EGCG inhibits the oxLDL-induced LOX-1-mediated signaling pathway, at least in part, by inhibiting NADPH oxidase and consequent ROS-enhanced LOX-1 expression, which contributes to further ROS generation and the subsequent activation of NF-kappaB via the p38 MAPK pathway.	ros	151-154	oxidized low density lipoprotein receptor 1	Homo sapiens	56-61
20203069-9	2010	These data suggest that EGCG inhibits the oxLDL-induced LOX-1-mediated signaling pathway, at least in part, by inhibiting NADPH oxidase and consequent ROS-enhanced LOX-1 expression, which contributes to further ROS generation and the subsequent activation of NF-kappaB via the p38 MAPK pathway.	ros	151-154	oxidized low density lipoprotein receptor 1	Homo sapiens	164-169
20203069-9	2010	These data suggest that EGCG inhibits the oxLDL-induced LOX-1-mediated signaling pathway, at least in part, by inhibiting NADPH oxidase and consequent ROS-enhanced LOX-1 expression, which contributes to further ROS generation and the subsequent activation of NF-kappaB via the p38 MAPK pathway.	ros	211-214	oxidized low density lipoprotein receptor 1	Homo sapiens	56-61
20203069-9	2010	These data suggest that EGCG inhibits the oxLDL-induced LOX-1-mediated signaling pathway, at least in part, by inhibiting NADPH oxidase and consequent ROS-enhanced LOX-1 expression, which contributes to further ROS generation and the subsequent activation of NF-kappaB via the p38 MAPK pathway.	ros	211-214	oxidized low density lipoprotein receptor 1	Homo sapiens	164-169
24025674-5	2013	These data demonstrate that the enhanced sensitivity of the Grx1-roGFP2 fusion protein enables the detection of short-lived ROS in living cells.	ros	124-127	glutaredoxin	Homo sapiens	60-64
34445509-7	2021	Prx-6 inhibits ROS production in mitochondria by increasing the antioxidant capacity of cells and altering the expression of genes encoding redox status proteins.	ros	15-18	peroxiredoxin 6	Homo sapiens	0-5
24098377-8	2013	Moreover, TQ-induced ROS production regulated p38 phosphorylation but not vice versa.	ros	21-24	mitogen-activated protein kinase 14	Mus musculus	46-49
34445509-8	2021	Due to the close bond between (Ca2+)i and intracellular ROS, this effect of Prx-6 is one of its protective mechanisms.	ros	56-59	peroxiredoxin 6	Homo sapiens	76-81
34400737-5	2021	Furthermore, the gene expression of the ROS-related necroinflammatory mediators (NF-kappaB, iNOS, COX-2, and TNF-alpha) in the kidney, brain, and spleen, as well as IL-1beta, and IL-8 in the lung were greatly restored.	ros	40-43	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	98-103
34118452-4	2021	Accumulation of damaged ROS-generating mitochondria, accompanied by the release of mitochondrial DAMPs, can activate PRRs such as the NLRP3 inflammasome, TLR9, cGAS/STING, and ZBP1.	ros	24-27	toll like receptor 9	Homo sapiens	154-158
20171273-3	2010	Here, to further investigate the role of HIPK2 in p53 activation, we started with the finding that HIPK2 inhibition upregulated Nox1, a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase, involved in tumor progression and ROS production.	ros	247-250	NADPH oxidase 1	Homo sapiens	128-132
20114059-6	2010	Suppression of antioxidant system coupled with increased generation of ROS eventually led to activation of caspase 3 during arsenic exposure.	ros	71-74	caspase 3	Rattus norvegicus	107-116
24086569-10	2013	Inhibition of ROS-induced Smad3 activation by carvedilol resulted in downregulation of Col1a1, Col3a1, and alpha-SMA and upregulation of miR-29b derived from the miR-29b-2 precursor.	ros	14-17	microRNA 29b-2	Rattus norvegicus	162-171
23982491-11	2013	The cardiotoxic effects of STC1 appears to be mediated via mitochondrial dysfunction as indicated by loss of mitochondrial membrane potential, ROS production and increased mitochondrial calcium levels.	ros	143-146	stanniocalcin 1	Homo sapiens	27-31
34299056-5	2021	In addition, suppression of TIGAR expression by siRNA decreased the levels of the proliferative marker PCNA and increased cellular ROS levels.	ros	131-134	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	28-33
23849170-11	2013	ULK1 knockdown decreased autophagy activation, increased mitochondrial mass and ROS exposure and sensitized cells to acute and chronic hypoxia.	ros	80-83	unc-51 like autophagy activating kinase 1	Homo sapiens	0-4
34140535-5	2021	In in vivo and in vitro tests of LSKs, Rg1 was found to increase mitochondrial number and the ratio of Bcl-2/Bax and to decrease damage to the mitochondrial inner and outer membranes, the mitochondrial Bax level and the protein levels of mitochondrial apoptosis-related proteins AIF and Cyt-C by decreasing the ROS level.	ros	311-314	protein phosphatase 1, regulatory subunit 3A	Mus musculus	39-42
34208208-5	2021	Moreover, we detected an ROS-mediated toxicity of the acute treatment with TGFbeta, whereas a chronic exposure to low doses had a protumorigenic effect.	ros	25-28	transforming growth factor alpha	Homo sapiens	75-82
20440404-6	2010	Although the list of mitochondrial proteins identified in this study is incomplete, we identified the downregulation of NDUFS3 from complex I of the respiratory chain and upregulation of COX5A, COX5B, and ATP5H from complex IV and V in ROs.	ros	236-239	cytochrome c oxidase subunit 5A	Homo sapiens	187-192
23976956-1	2013	We have recently shown that p38MAP kinase (p38MAPK) stimulates ROS generation via the activation of NADPH oxidase during neonatal hypoxia-ischemia (HI) brain injury.	ros	63-66	mitogen activated protein kinase 14	Rattus norvegicus	28-41
20440404-6	2010	Although the list of mitochondrial proteins identified in this study is incomplete, we identified the downregulation of NDUFS3 from complex I of the respiratory chain and upregulation of COX5A, COX5B, and ATP5H from complex IV and V in ROs.	ros	236-239	cytochrome c oxidase subunit 5B	Homo sapiens	194-199
34093596-6	2021	Park7 knockdown exacerbated TGFB1-induced fibrotic changes, cell apoptosis and ROS production, whereas Park7 overexpression or treatment with ND-13 (a PARK7-derived peptide) attenuated these TGFB1-induced changes.	ros	79-82	transforming growth factor, beta 1	Mus musculus	28-33
23976956-1	2013	We have recently shown that p38MAP kinase (p38MAPK) stimulates ROS generation via the activation of NADPH oxidase during neonatal hypoxia-ischemia (HI) brain injury.	ros	63-66	mitogen activated protein kinase 14	Rattus norvegicus	43-50
34065695-6	2021	Furthermore, we found AKR1C3 was inversely correlated with ROS production.	ros	59-62	aldo-keto reductase family 1 member C3	Homo sapiens	22-28
20136621-5	2010	The 80% ethanol extract of APL showed a significant activity to inhibit NO release and ROS production.	ros	87-90	neuraminidase 1	Mus musculus	27-30
23721786-3	2013	We hypothesized that inhibition of ROS production would prevent PD symptoms in the LRRK2(R1441G) transgenic (tg) mouse model of PD.	ros	35-38	leucine-rich repeat kinase 2	Mus musculus	83-88
19956840-2	2010	We have previously shown that metabolic stress due to glucose depletion (GD) induces necrosis and HMGB1 release through mitochondrial ROS production in A549 lung adenocarcinoma cells.	ros	134-137	high mobility group box 1	Homo sapiens	98-103
34065695-8	2021	AKT phosphorylation was regulated by AKR1C3 and might be responsible for eliminating over-produced ROS in EAC cells.	ros	99-102	aldo-keto reductase family 1 member C3	Homo sapiens	37-43
34065695-10	2021	Here, we reported for the first time that AKR1C3 renders chemotherapy resistance through controlling ROS levels via AKT signaling in EAC cells.	ros	101-104	aldo-keto reductase family 1 member C3	Homo sapiens	42-48
23597505-8	2013	Importantly, H2O2 increased the UCP3-mediated proton leak, suggesting a role for this protein in attenuating ROS-induced damage.	ros	109-112	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	32-36
34254926-4	2021	Oxidative stress-driven by ROS production also affects the Hippo pathway with transcriptional changes through MST/YAP/FoxO pathway and leads to the activation of pro-apoptotic genes and eventually cell death.	ros	27-30	Yes1 associated transcriptional regulator	Homo sapiens	114-117
19574557-1	2009	OBJECTIVE: Because Nox2-containing NADPH oxidase is a major source of ROS in the vasculature, we investigated its potential role for the modulation of ischemia-induced neovascularization in conditions of increased oxidative stress.	ros	70-73	cytochrome b-245, beta polypeptide	Mus musculus	19-23
23597505-9	2013	Nrf2 nuclear accumulation and increased UCP3 protein were also detected in intact mouse heart subjected to a condition known to increase ROS generation.	ros	137-140	uncoupling protein 3 (mitochondrial, proton carrier)	Mus musculus	40-44
35525345-10	2022	Taken together, our results indicated that ROS induced by low-dose arsenic exposure determined energy metabolic reprogramming and acted a critical regulator for AKT-dependent HK2 expression and aerobic glycolysis.	ros	43-46	hexokinase 2	Homo sapiens	175-178
23800068-9	2013	Azelaic acid may decrease mTORC1 by inhibiting mitochondrial respiration, increasing cellular ROS and nuclear FoxO levels.	ros	94-97	CREB regulated transcription coactivator 1	Mus musculus	26-32
35526619-10	2022	Mechanistic analyses revealed SiNPs induced myocardial apoptosis via ROS/Ca2+/CaMKII signaling, which may contribute to the abnormalities in cardiac structure and function in vivo.	ros	69-72	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	78-84
35526619-11	2022	In summary, our research revealed SiNPs caused myocardial impairments, dysfunction and even structural remodeling via ROS/Ca2+/CaMKII signaling.	ros	118-121	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	127-133
19572226-2	2009	Using primary human trabecular meshwork (TM) cells from normal and glaucomatous subjects, this study demonstrated that peroxiredoxin (PRDX) 6, an antioxidant, offsets the deleterious effects of oxidative stress on TM cells by optimizing ROS and TGFbeta levels.	ros	237-240	peroxiredoxin 6	Homo sapiens	134-141
19428456-8	2009	Regardless of dietary UQ, clk-1 animals have increased lifespan, decreased mitochondrial respiration, and decreased ROS damage to mitochondrial protein than N2.	ros	116-119	5-demethoxyubiquinone hydroxylase, mitochondrial	Caenorhabditis elegans	26-31
23746969-3	2013	(2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.	ros	110-113	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	60-64
19281832-5	2009	Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively.	ros	113-116	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	44-50
19281832-5	2009	Moreover, IL-1beta stimulated NF-kappaB and CaMKII phosphorylation through MyD88-dependent PI-PLC/PKCalpha/c-Src/ROS and PI-PLC/Ca2+/CaM pathways, respectively.	ros	113-116	MYD88 innate immune signal transduction adaptor	Homo sapiens	75-80
35576681-7	2022	TBN also significantly reduced ROS levels and superoxide accumulation in C. elegans.	ros	31-34	TATA-box binding protein associated factor 8	Homo sapiens	0-3
35064565-12	2022	SMC Rac1 deletion also limited hypoxia-induced PA remodeling and ROS production in PASMCs.	ros	65-68	Rac family small GTPase 1	Mus musculus	4-8
35064565-14	2022	Rac1 activity in PASMCs plays a causal role in PH by favoring ROS-dependent PA remodeling and endothelial dysfunction induced by chronic hypoxia.	ros	62-65	Rac family small GTPase 1	Mus musculus	0-4
23092805-12	2013	One may speculate that the Ang-II-mediated loss of muscle force is due to an activation of NAD(P)H oxidase expression and a subsequent ROS-induced down regulation of IGF-1, PGC-1alpha and Sirt1.	ros	135-138	insulin-like growth factor 1	Mus musculus	166-171
23092805-12	2013	One may speculate that the Ang-II-mediated loss of muscle force is due to an activation of NAD(P)H oxidase expression and a subsequent ROS-induced down regulation of IGF-1, PGC-1alpha and Sirt1.	ros	135-138	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	173-183
23688756-6	2013	RESULTS: ROS and apoptosis of BMMNC, myelocytes, erythrocytes and stem cells of iron overloading IRP patients were significantly higher than that of non-iron overloading IRP ones and normal controls (P &lt; 0.05).	ros	9-12	Wnt family member 2	Homo sapiens	97-100
35245516-12	2022	CONCLUSIONS: Endothelial Ccni acts as a critical negative regulator of eNos uncoupling-mediated ROS generation and thereby reduces vulnerability to hypertension-induced vascular remodeling and AAA development in mice.	ros	96-99	cyclin I	Mus musculus	25-29
19413946-0	2009	UCP2, not a physiologically relevant uncoupler but a glucose sparing switch impacting ROS production and glucose sensing.	ros	86-89	uncoupling protein 2	Homo sapiens	0-4
23343509-11	2013	Our results support the notion that GLP1 receptor agonists restore eNOS-induced ROS production due to lipotoxicity and that such agonists protect against lipoapoptosis through PKA-PI3K/Akt-eNOS-p38 MAPK-JNK-dependent pathways via a GLP1 receptor-dependent mechanism.	ros	80-83	glucagon like peptide 1 receptor	Homo sapiens	36-40
19413946-2	2009	Accordingly, it was proposed that UCP2 and UCP3 are also uncoupling proteins i.e. protonophores with impact on mitochondrial ROS production and glucose signaling.	ros	125-128	uncoupling protein 2	Homo sapiens	34-38
23343509-11	2013	Our results support the notion that GLP1 receptor agonists restore eNOS-induced ROS production due to lipotoxicity and that such agonists protect against lipoapoptosis through PKA-PI3K/Akt-eNOS-p38 MAPK-JNK-dependent pathways via a GLP1 receptor-dependent mechanism.	ros	80-83	glucagon like peptide 1 receptor	Homo sapiens	36-49
35504726-15	2022	Mechanistically, USP2 mitigates the accumulation of ROS in the VMH, resulting in attenuation of the phosphorylation of AMP-activated protein kinase (AMPK).	ros	52-55	ubiquitin specific peptidase 2	Mus musculus	17-21
35504726-15	2022	Mechanistically, USP2 mitigates the accumulation of ROS in the VMH, resulting in attenuation of the phosphorylation of AMP-activated protein kinase (AMPK).	ros	52-55	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	119-147
19427492-5	2009	Indeed, there is a mounting body of evidence that the resultant insulin resistance in cardiovascular tissue and kidneys contributes to the development of endothelial dysfunction, HTN, atherosclerosis, CKD, and CVD.77 RAAS-associated signaling by way of the AT1R and MR, triggers tissue activation of the NADPH oxidase enzymatic activation and increased production of ROS.	ros	367-370	angiotensin II receptor type 1	Homo sapiens	257-261
23220213-0	2013	Cyclophilin 40 alters UVA-induced apoptosis and mitochondrial ROS generation in keratinocytes.	ros	62-65	peptidylprolyl isomerase D	Homo sapiens	0-14
35504726-15	2022	Mechanistically, USP2 mitigates the accumulation of ROS in the VMH, resulting in attenuation of the phosphorylation of AMP-activated protein kinase (AMPK).	ros	52-55	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	149-153
35367811-6	2022	XBP1 deficiency increased ROS production to promote hepatocellular pyroptosis by activating NLRP3/caspase-1/GSDMD signaling, which facilitated the extracellular release of mtDNA.	ros	26-29	caspase 1	Mus musculus	98-107
35597868-7	2022	RESULTS: Bioinformatic analysis, in vitro, and in vivo experiments revealed that ALDH1L2 is a radiation-related gene, and a decrease in its expression induces radioresistance in CRC cells by inhibiting ROS-mediated apoptosis.	ros	202-205	aldehyde dehydrogenase 1 family member L2	Homo sapiens	81-88
23271700-7	2013	Residues Tyr231 and Val232 also seemed to be important for p47phox function, as p47phox_Y231G and p47phox_V232G resulted in a &gt;50% decrease in ROS production by the NOX2 complex.	ros	146-149	cytochrome b-245, beta polypeptide	Mus musculus	168-172
19402212-3	2009	VSMC transfected with wild-type PDI (wt-PDI) or PDI mutated in all four redox cysteines (mut-PDI) enhanced (2.5-fold) basal cellular ROS production and membrane NADPH oxidase activity, with 3-fold increase in Nox1, but not Nox4 mRNA.	ros	133-136	prolyl 4-hydroxylase subunit beta	Homo sapiens	32-35
19402212-3	2009	VSMC transfected with wild-type PDI (wt-PDI) or PDI mutated in all four redox cysteines (mut-PDI) enhanced (2.5-fold) basal cellular ROS production and membrane NADPH oxidase activity, with 3-fold increase in Nox1, but not Nox4 mRNA.	ros	133-136	prolyl 4-hydroxylase subunit beta	Homo sapiens	40-43
19402212-3	2009	VSMC transfected with wild-type PDI (wt-PDI) or PDI mutated in all four redox cysteines (mut-PDI) enhanced (2.5-fold) basal cellular ROS production and membrane NADPH oxidase activity, with 3-fold increase in Nox1, but not Nox4 mRNA.	ros	133-136	prolyl 4-hydroxylase subunit beta	Homo sapiens	40-43
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	ros	171-174	fibroblast growth factor receptor 4	Homo sapiens	24-29
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	ros	171-174	transcription factor 4	Homo sapiens	124-128
19402212-3	2009	VSMC transfected with wild-type PDI (wt-PDI) or PDI mutated in all four redox cysteines (mut-PDI) enhanced (2.5-fold) basal cellular ROS production and membrane NADPH oxidase activity, with 3-fold increase in Nox1, but not Nox4 mRNA.	ros	133-136	prolyl 4-hydroxylase subunit beta	Homo sapiens	40-43
23271700-9	2013	In conclusion, the p47phox protein variant expressed in Ncf1(m1J) mice is completely defective in activating the NOX2 complex to produce ROS, and the effect is dependent on SH3 region amino acids at positions 231-233, which are vital for the proper assembly of the NOX2 complex.	ros	137-140	cytochrome b-245, beta polypeptide	Mus musculus	113-117
35594653-4	2022	Mechanistic investigations showed that compound a21-2 induces ROS production, which subsequently causes DNA damage and activation of ATM/Chk2, leading to G2/M phase arrest.	ros	62-65	checkpoint kinase 2	Homo sapiens	137-141
23861715-7	2013	Administration of QSYQ could attenuate LAD-induced HF, and AngII-NOX2-ROS-MMPs pathway seemed to be the critical potential targets for QSYQ to reduce the remodeling.	ros	70-73	matrix metallopeptidase 2	Rattus norvegicus	74-78
35507395-9	2022	At therapeutically achievable concentrations metformin acted as a senostatic neither via inhibition of mitochondrial complex I, nor via improvement of mitophagy or mitochondrial function, but by reducing non-mitochondrial ROS production via NOX4 inhibition in senescent cells.	ros	222-225	NADPH oxidase 4	Mus musculus	241-245
18952046-0	2009	High efficiency of ROS production by glycerophosphate dehydrogenase in mammalian mitochondria.	ros	19-22	glycerol-3-phosphate dehydrogenase 1	Homo sapiens	37-67
23758151-0	2013	Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS-mediated MAPK pathways.	ros	99-102	programmed cell death 4	Homo sapiens	20-25
24080574-12	2013	CONCLUSION: ROS induction by palmitate leads to ERK1/2 phosphorylation and subsequently induces the osteogenic differentiation of VSMC.	ros	12-15	mitogen activated protein kinase 3	Rattus norvegicus	48-54
35501301-0	2022	A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis.	ros	117-120	24-dehydrocholesterol reductase	Homo sapiens	110-116
35501301-7	2022	The novel SRSF3 inhibitor SFI003 exhibits potent antitumor efficacy in vitro and in vivo, which drives apoptosis of CRC cells via the SRSF3/DHCR24/reactive oxygen species (ROS) axis.	ros	172-175	24-dehydrocholesterol reductase	Homo sapiens	140-146
35115667-7	2022	Inhibiting neuronal Hv1 genetically or by a newly discovered selective inhibitor YHV98-4 reduced intracellular alkalization and ROS production in inflammatory pain, mitigated the imbalance in downstream SHP-1-pAKT signaling, and also diminished pro-inflammatory chemokine release to alleviate nociception and morphine-induced hyperalgesia and tolerance.	ros	128-131	hydrogen voltage gated channel 1	Homo sapiens	20-23
35138513-5	2022	Moreover, TGF-beta increased the expression of p-Smad2/3-NOX4 in LX-2 cells and consequently increased ROS content, which is a trigger for NLRP3 inflammasome activation.	ros	103-106	transforming growth factor alpha	Homo sapiens	10-18
20003713-1	2009	Peroxiredoxins are thiol-specific antioxidants that catalyze the reduction of cellular peroxides and protect cells from ROS-mediated damage and death.	ros	120-123	peroxiredoxin 6	Mus musculus	0-14
23108227-9	2013	The present results demonstrated for the first time that PEDF could block the AGE-induced apoptotic cell death of podocytes by suppressing RAGE expression and subsequent ROS generation partly via PPARgamma activation.	ros	170-173	serpin family F member 1	Homo sapiens	57-61
19018768-0	2008	Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT.	ros	100-103	aryl hydrocarbon receptor	Homo sapiens	126-129
35138513-5	2022	Moreover, TGF-beta increased the expression of p-Smad2/3-NOX4 in LX-2 cells and consequently increased ROS content, which is a trigger for NLRP3 inflammasome activation.	ros	103-106	SMAD family member 2	Homo sapiens	49-56
35138513-5	2022	Moreover, TGF-beta increased the expression of p-Smad2/3-NOX4 in LX-2 cells and consequently increased ROS content, which is a trigger for NLRP3 inflammasome activation.	ros	103-106	NADPH oxidase 4	Homo sapiens	57-61
22773120-5	2012	Importantly, miR-338 modulation of local COXIV and ATP5G1 expression has a marked effect on axonal ROS levels, as well as axonal growth.	ros	99-102	cytochrome c oxidase subunit 4I1	Homo sapiens	41-46
35514986-5	2022	We found that miR-582 overexpression disturbed the mitochondrial metabolism of BCP-ALL cells, leading to less ATP but more ROS production.	ros	123-126	microRNA 582	Homo sapiens	14-21
35404404-6	2022	ABA-activated BAK1 phosphorylated AHA2 at Ser-944 in its C terminus and activated AHA2, leading to rapid H+ efflux, cytoplasmic alkalinization, and ROS accumulation, to initiate ABA signal transduction and stomatal closure.	ros	148-151	BRI1-associated receptor kinase	Arabidopsis thaliana	14-18
18622616-8	2008	Furthermore, we speculate that Tar1p is down-regulated when respiration is defective to prevent deleterious ROS-dependent consequences of mitochondrial dysfunction.	ros	108-111	Tar1p	Saccharomyces cerevisiae S288C	31-36
18219322-6	2008	TNF-induced SENP1 nuclear translocation is specifically blocked by antioxidants such as N-acetyl-cysteine, suggesting that TNF-induced translocation of SENP1 is ROS dependent.	ros	161-164	SUMO1/sentrin specific peptidase 1	Mus musculus	12-17
18219322-6	2008	TNF-induced SENP1 nuclear translocation is specifically blocked by antioxidants such as N-acetyl-cysteine, suggesting that TNF-induced translocation of SENP1 is ROS dependent.	ros	161-164	SUMO1/sentrin specific peptidase 1	Mus musculus	152-157
35218740-0	2022	Carbon monoxide releasing molecule-2 attenuates angiotensin II-induced IL-6/Jak2/Stat3-associated inflammation by inhibiting NADPH oxidase- and mitochondria-derived ROS in human aortic smooth muscle cells.	ros	165-168	Janus kinase 2	Homo sapiens	76-80
22773120-5	2012	Importantly, miR-338 modulation of local COXIV and ATP5G1 expression has a marked effect on axonal ROS levels, as well as axonal growth.	ros	99-102	ATP synthase membrane subunit c locus 1	Homo sapiens	51-57
35218740-6	2022	The results showed that Ang II induced inflammatory responses of HASMCs via NADPH oxidase- and mitochondria-derived ROS/NF-kappaB/IL-6/Jak2/Stat3 pathway which was attenuated by the pretreatment with CORM-2.	ros	116-119	Janus kinase 2	Homo sapiens	135-139
22847064-5	2012	In this study, we observed that LOX-1 expression is induced upon toxic microglial activation, and discovered that LOX-1 is necessary in microglia for sensing soluble neuronal injury signal(s) in the conditioned medium to induce generation of pro-inflammatory mediators (IL-1beta, TNF-alpha, NO and ROS) that promote neurotoxicity.	ros	298-301	oxidized low density lipoprotein receptor 1	Homo sapiens	114-119
18201545-1	2008	Reactive nitrogen species (RNS) and oxygen species (ROS) have been reported to modulate the function of nitric oxide synthase (NOS); however, the precise dose-dependent effects of specific RNS and ROS on NOS function are unknown.	ros	52-55	nitric oxide synthase 1	Homo sapiens	104-125
22847064-6	2012	Employing a unique eukaryotic HSP60-overexpression method, we further demonstrated that extracellular HSP60 acts on microglial LOX-1 to boost the production of pro-inflammatory factors (IL-1beta, NO and ROS) in microglia and to propagate neuronal damage.	ros	203-206	oxidized low density lipoprotein receptor 1	Homo sapiens	127-132
18201545-1	2008	Reactive nitrogen species (RNS) and oxygen species (ROS) have been reported to modulate the function of nitric oxide synthase (NOS); however, the precise dose-dependent effects of specific RNS and ROS on NOS function are unknown.	ros	197-200	nitric oxide synthase 1	Homo sapiens	104-125
35475417-5	2022	Functional assays demonstrated that ACE2 addition promoted cell viability, suppressed apoptosis, oxidative stress, ROS generation, and inflammation in HG-stimulated HMEC-1 cells.	ros	115-118	angiotensin converting enzyme 2	Homo sapiens	36-40
35178859-0	2022	Radiation-induced C-reactive protein triggers apoptosis of vascular smooth muscle cells through ROS interfering with the STAT3/Ref-1 complex.	ros	96-99	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	127-132
23308066-0	2012	COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production.	ros	95-98	cytochrome c oxidase subunit 5B	Homo sapiens	0-5
35065161-6	2022	Increased ROS production by IMPAs also promotes p53 mediated cell cycle arrest through the inactivation of p38MAPK.	ros	10-13	histocompatibility minor 13	Homo sapiens	28-33
35433874-0	2022	CagA+ Helicobacter pylori, Not CagA- Helicobacter pylori, Infection Impairs Endothelial Function Through Exosomes-Mediated ROS Formation.	ros	123-126	S100 calcium binding protein A8	Homo sapiens	0-4
35433874-3	2022	The present study aimed to test the hypothesis that CagA+ H. pylori effectively colonizes gastric mucosa, and CagA+ H. pylori, but not CagA- H. pylori, infection impairs endothelial function through exosomes-mediated ROS formation.	ros	217-220	S100 calcium binding protein A8	Homo sapiens	110-114
35433874-9	2022	CagA+ H. pylori, not CagA- H. pylori, infection significantly increased aortic ROS production, decreased ACh-induced aortic relaxation, and enhanced early atherosclerosis formation, which were prevented with N-acetylcysteine treatment.	ros	79-82	S100 calcium binding protein A8	Homo sapiens	0-4
35433874-10	2022	Treatment with CagA-containing exosomes significantly increased intracellular ROS production in endothelial cells and impaired their function.	ros	78-81	S100 calcium binding protein A8	Homo sapiens	15-19
35433874-12	2022	Conclusion: These data suggest that CagA+ H. pylori effectively colonizes gastric mucosa, impairs endothelial function, and enhances atherosclerosis via exosomes-mediated ROS formation in mice.	ros	171-174	S100 calcium binding protein A8	Homo sapiens	36-40
17855623-1	2008	Uncoupling protein-2 (UCP2) belongs to the mitochondrial carrier family and has been thought to be involved in suppressing mitochondrial ROS production through uncoupling mitochondrial respiration from ATP synthesis.	ros	137-140	uncoupling protein 2	Homo sapiens	0-20
17855623-1	2008	Uncoupling protein-2 (UCP2) belongs to the mitochondrial carrier family and has been thought to be involved in suppressing mitochondrial ROS production through uncoupling mitochondrial respiration from ATP synthesis.	ros	137-140	uncoupling protein 2	Homo sapiens	22-26
18395354-6	2008	Presently, accumulative research data showed that BVR was a strong antioxidant enzyme, which could scavenge the excess ROS, and the characteristics of kinase activity and binding with p85 could modulate the biological function of IRS-1 and PI3K.	ros	119-122	biliverdin reductase A	Homo sapiens	50-53
35302183-0	2022	Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-alpha expression in hydroquinone-treated leukemia cells.	ros	78-81	NADPH oxidase 4	Homo sapiens	31-35
23308066-6	2012	Mechanistically, we find that while activation of MAVS leads to increased ROS production and COX5B expression, COX5B down-regulated MAVS signaling by repressing ROS production.	ros	161-164	cytochrome c oxidase subunit 5B	Homo sapiens	111-116
35093305-9	2022	In addition, the in vitro and in vivo experiments showed that ZEB1/MCT4 in synergy promoted the growth of breast cancer through ROS generation and autophagy, which can be reversed by a MCT4 inhibitor, 7ACC1.	ros	128-131	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	67-71
22982676-13	2012	CONCLUSION: This study demonstrates that palmitate induces ROS production and that the palmitate induced lipotoxicity is the result of increased ROS production, where the ROS sensitive MKK3/6-p38 pathway mediates lipoapoptosis of GLP-1-secreting cells.	ros	59-62	mitogen-activated protein kinase 14	Mus musculus	192-195
35093305-9	2022	In addition, the in vitro and in vivo experiments showed that ZEB1/MCT4 in synergy promoted the growth of breast cancer through ROS generation and autophagy, which can be reversed by a MCT4 inhibitor, 7ACC1.	ros	128-131	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	185-189
35093305-10	2022	CONCLUSION: ZEB1 directly binds to E-box elements of MCT4 promoter and enhance MCT4 expression, inducing ROS accumulation, which cooperatively resulting in breast cancer growth and shorten survival.	ros	105-108	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	53-57
22982676-13	2012	CONCLUSION: This study demonstrates that palmitate induces ROS production and that the palmitate induced lipotoxicity is the result of increased ROS production, where the ROS sensitive MKK3/6-p38 pathway mediates lipoapoptosis of GLP-1-secreting cells.	ros	145-148	mitogen-activated protein kinase 14	Mus musculus	192-195
35093305-10	2022	CONCLUSION: ZEB1 directly binds to E-box elements of MCT4 promoter and enhance MCT4 expression, inducing ROS accumulation, which cooperatively resulting in breast cancer growth and shorten survival.	ros	105-108	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	79-83
18075836-9	2007	Our findings suggested that retinol-induced MMP-2 activity, but not retinoic acid-induced MMP-2 activity, was related to ERK1/2 phosphorylation and ROS production.	ros	148-151	matrix metallopeptidase 2	Homo sapiens	44-49
22982676-13	2012	CONCLUSION: This study demonstrates that palmitate induces ROS production and that the palmitate induced lipotoxicity is the result of increased ROS production, where the ROS sensitive MKK3/6-p38 pathway mediates lipoapoptosis of GLP-1-secreting cells.	ros	145-148	mitogen-activated protein kinase 14	Mus musculus	192-195
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	105-108	aryl hydrocarbon receptor	Homo sapiens	164-189
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	105-108	aryl hydrocarbon receptor	Homo sapiens	191-194
22709585-4	2012	Striatal cells expressing mutant huntingtin show higher basal levels of mitochondrial-generated ROS and mtDNA lesions and a lower spare respiratory capacity.	ros	96-99	huntingtin	Homo sapiens	33-43
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	255-258	aryl hydrocarbon receptor	Homo sapiens	191-194
35246121-4	2022	Here we evaluated, in a longitudinal cohort of dysglycemic population the relation between the circulating miR-21/ROS/HNE levels and the habit-intervention (HI) after 1 year of follow-up.	ros	114-117	elastase, neutrophil expressed	Homo sapiens	118-121
35246121-9	2022	The associations between glycemic parameters and miR-21/ROS/HNE were implemented by linear regression and logistic regression models.	ros	56-59	elastase, neutrophil expressed	Homo sapiens	60-63
17596519-6	2007	Cells with reduced PNC1 expression have reduced mitochondrial UTP levels, but while mitochondrial membrane potential and cellular ATP are not altered, cellular ROS levels are increased.	ros	160-163	nicotinamidase	Saccharomyces cerevisiae S288C	19-23
17462535-10	2007	This study establishes that AGE activate iNOS in VSMC through a ROS-sensitive, NF-kappaB-dependent mechanism involving ROS generation by a Nox1-based oxidase.	ros	64-67	NADPH oxidase 1	Homo sapiens	139-143
17462535-10	2007	This study establishes that AGE activate iNOS in VSMC through a ROS-sensitive, NF-kappaB-dependent mechanism involving ROS generation by a Nox1-based oxidase.	ros	119-122	NADPH oxidase 1	Homo sapiens	139-143
35246513-10	2022	The ability of DNMT1 to repress SIRT6 promoter partly was dependent on ROS-sensitive serine 154 phosphorylation.	ros	71-74	sirtuin 6	Homo sapiens	32-37
23047940-14	2012	NF-kappaB pathway is not incorporated in ETA-R and ETB-R influence on ROS production.	ros	70-73	endothelin receptor type B	Rattus norvegicus	51-56
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	cytochrome b-245, beta polypeptide	Mus musculus	182-186
22561604-7	2012	In vitro and in vivo studies have demonstrated the ability of plasmin to stimulate the production of cytokines, ROS, and other mediators, thereby contributing to inflammation.	ros	112-115	plasminogen	Homo sapiens	62-69
35193583-6	2022	Results of RNA-sequencing and in vitro experiments showed that ACaT promoted tumor cell apoptosis and inhibited tumor cell migration by arresting the cell cycle, increasing ROS and affecting calcium homeostasis.	ros	173-176	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	63-67
35183200-0	2022	Cucurbitacin B inhibits TGF-beta1-induced epithelial-mesenchymal transition (EMT) in NSCLC through regulating ROS and PI3K/Akt/mTOR pathways.	ros	110-113	transforming growth factor, beta 1	Mus musculus	24-33
35183200-17	2022	CONCLUSION: CuB inhibits EMT in TGF-beta1-induced A549 cells and Gefitinib resistant A549 cells through decreasing ROS production and PI3K/Akt/mTOR signaling pathway.	ros	115-118	transforming growth factor, beta 1	Mus musculus	32-41
17429808-5	2007	The culture of rat osteosarcoma 17/2.8 (ROS), osteoblastic-like cells, demonstrates that the grafting of RGDS can enhance the attachment and osteogenesis of ROS cells on PLLA.	ros	40-43	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	105-109
17429808-5	2007	The culture of rat osteosarcoma 17/2.8 (ROS), osteoblastic-like cells, demonstrates that the grafting of RGDS can enhance the attachment and osteogenesis of ROS cells on PLLA.	ros	157-160	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	105-109
17939209-10	2007	LOX-1 expression increased also through oxygen species (ROS), endothelin-1 (ET-1), tumor necrosis factor-alpha (TNF-alpha), shear stress, activation of protein kinase-C (PKC), angiotensin-II (ANG-II), and through inflammatory pathways.	ros	56-59	oxidized low density lipoprotein receptor 1	Homo sapiens	0-5
22634137-7	2012	Estrogen replacement (OVX/E2) rescued vascular PPARgamma-expression, reduced ROS generation, monocyte recruitment, atherosclerotic lesion formation and improved endothelial function.	ros	77-80	ATPase, H+ transporting, lysosomal V1 subunit E1	Mus musculus	22-28
22552773-0	2012	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	ros	44-47	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	21-27
35133388-5	2022	SPEPS@Au mitigated amyloidogenesis of IAPP at low sub-stoichiometric concentrations, even after IAPP started aggregating, and dramatically reduced the amyloidogenesis-induced toxicity and ROS production both in vitro and in vivo.	ros	188-191	islet amyloid polypeptide	Homo sapiens	38-42
16883569-8	2006	Finally, we found that direct induction of mitochondrial elongation by blocking mitochondrial fission process with Fis1-DeltaTM or Drp1-K38A was sufficient to develop senescent phenotypes with increased ROS production.	ros	203-206	collapsin response mediator protein 1	Homo sapiens	131-135
35215995-10	2022	Collectively, EP can prevent PEDV internalization, replication and release, possesses the ability to directly inactivate PEDV, and can inhibit PEDV-induced apoptosis by interfering with PEDV-induced ROS production and p53 activation.	ros	199-202	epiregulin	Homo sapiens	14-16
22626465-0	2012	Astaxanthin attenuates the UVB-induced secretion of prostaglandin E2 and interleukin-8 in human keratinocytes by interrupting MSK1 phosphorylation in a ROS depletion-independent manner.	ros	152-155	ribosomal protein S6 kinase A5	Homo sapiens	126-130
35144642-8	2022	Activated ROS-metabolism was identified in METTL7B-overexpressed LUAD cells, accompanied with upregulated protein level of GPX4, HMOX1 and SOD1 and their enzymatic activities.	ros	10-13	methyltransferase like 7B	Mus musculus	43-50
16772302-2	2006	This study shows that hyperosmotic ROS formation involves a rapid ceramide- and protein kinase Czeta (PKCzeta)-dependent serine phosphorylation of p47phox and subsequent activation of NADPH oxidase isoforms.	ros	35-38	neutrophil cytosolic factor 1	Rattus norvegicus	147-154
16466682-3	2006	Treatment of ROS 17/2.8 cells with either 10 ng/ml FGF2 or 1 microM FSK for 6 h resulted in 5.4- and 8.2-fold increases, respectively, in the levels of BSP mRNA.	ros	13-16	fibroblast growth factor 2	Rattus norvegicus	51-55
16428270-4	2006	The activities of RhoA, Rac1, and Cdc42 were correlated with changes in the endothelial cytoskeleton, adherens junctions, permeability, ROS production, VEGF levels, and activities of transcription factors hypoxia-inducible factor (HIF)-1alpha and NF-kappaB.	ros	136-139	cell division cycle 42	Homo sapiens	34-39
22652796-0	2012	BMP2 induces PANC-1 cell invasion by MMP-2 overexpression through ROS and ERK.	ros	66-69	bone morphogenetic protein 2	Homo sapiens	0-4
16331683-4	2006	Activation of a NADPH-oxidase-like system, which is responsible for the early ROS production by TGF-beta, is completely inhibited by EGF, through a PI 3-K-dependent mechanism.	ros	78-81	epidermal growth factor like 1	Rattus norvegicus	133-136
35225488-13	2022	In addition, ECS and EFS reduced ROS expression in Vero cells caused by doxorubicin.	ros	33-36	epistatic circling SWR/J	Mus musculus	13-16
35225488-15	2022	ECS and EFS also exhibit ROS suppressing effect on Vero cells that may be beneficent to reduce nephrotoxicity of chemotherapeutic treatment.	ros	25-28	epistatic circling SWR/J	Mus musculus	0-3
22652796-0	2012	BMP2 induces PANC-1 cell invasion by MMP-2 overexpression through ROS and ERK.	ros	66-69	matrix metallopeptidase 2	Homo sapiens	37-42
16298758-7	2006	The ability of the N-LT marker to characterize oxidative stress in macrophage cell lines was first studied using different types of ROS/RNS.	ros	132-135	solute carrier family 22 (organic anion transporter), member 7	Mus musculus	19-23
22652796-2	2012	We hypothesized that BMP2 promotes cancer metastasis by modulating MMP-2 secretion and activity through intracellular ROS regulation and ERK activation in human pancreatic cancer.	ros	118-121	bone morphogenetic protein 2	Homo sapiens	21-25
22652796-2	2012	We hypothesized that BMP2 promotes cancer metastasis by modulating MMP-2 secretion and activity through intracellular ROS regulation and ERK activation in human pancreatic cancer.	ros	118-121	matrix metallopeptidase 2	Homo sapiens	67-72
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	12-15	matrix metallopeptidase 2	Homo sapiens	110-115
35051590-7	2022	Furthermore, we showed that NOX4, the main source of ROS in renal tubular, was down-regulated by Cx32.	ros	53-56	NADPH oxidase 4	Mus musculus	28-32
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	12-15	matrix metallopeptidase 2	Homo sapiens	178-183
35051590-7	2022	Furthermore, we showed that NOX4, the main source of ROS in renal tubular, was down-regulated by Cx32.	ros	53-56	gap junction protein, beta 1	Rattus norvegicus	97-101
35204109-4	2022	Peroxiredoxin 6 (PRDX6) possesses peroxidase and Ca2+-independent-phospholipase-A2 (iPLA2) activities that scavenge ROS and repair oxidized sperm membranes, respectively.	ros	116-119	peroxiredoxin 6	Mus musculus	0-15
35204109-4	2022	Peroxiredoxin 6 (PRDX6) possesses peroxidase and Ca2+-independent-phospholipase-A2 (iPLA2) activities that scavenge ROS and repair oxidized sperm membranes, respectively.	ros	116-119	peroxiredoxin 6	Mus musculus	17-22
15983010-2	2005	Through transgenic manipulation it has previously been shown that overexpression of SIPK leads to enhanced ozone-induced lesion formation with concomitant accumulation of ROS.	ros	171-174	mitogen-activated protein kinase homolog NTF4-like	Nicotiana tabacum	84-88
35058429-8	2022	Specifically, Pex3-/- mice produced elevated amounts of ROS, which damaged germ cell DNA and further activated the signaling pathway of the cell senescence regulatory protein P16-CDK6, resulting in cell cycle arrest and eventually contributing to spermatogenesis dysfunction.	ros	56-59	cyclin-dependent kinase 6	Mus musculus	179-183
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	12-15	bone morphogenetic protein 2	Homo sapiens	198-202
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	matrix metallopeptidase 2	Homo sapiens	110-115
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	matrix metallopeptidase 2	Homo sapiens	178-183
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	bone morphogenetic protein 2	Homo sapiens	198-202
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	matrix metallopeptidase 2	Homo sapiens	110-115
35111186-1	2021	Alternative oxidase (AOX) is an important component of the plant respiratory pathway, enabling a route for electrons that bypasses the energy-conserving, ROS-producing complexes of the mitochondrial electron transport chain.	ros	154-157	ubiquinol oxidase 1, mitochondrial	Glycine max	0-19
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	matrix metallopeptidase 2	Homo sapiens	178-183
35111186-1	2021	Alternative oxidase (AOX) is an important component of the plant respiratory pathway, enabling a route for electrons that bypasses the energy-conserving, ROS-producing complexes of the mitochondrial electron transport chain.	ros	154-157	ubiquinol oxidase 1, mitochondrial	Glycine max	21-24
15603814-3	2005	Results of experiments of cell culture with rat osteosarcoma (ROS) cells demonstrated that RGDS immobilization could enhance the attachment of ROS cells onto the chitosan, resulting in higher cell density attached to the RGDS-modified scaffold than to the unmodified scaffold.	ros	62-65	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	91-95
15603814-3	2005	Results of experiments of cell culture with rat osteosarcoma (ROS) cells demonstrated that RGDS immobilization could enhance the attachment of ROS cells onto the chitosan, resulting in higher cell density attached to the RGDS-modified scaffold than to the unmodified scaffold.	ros	62-65	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	221-225
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	bone morphogenetic protein 2	Homo sapiens	198-202
15603814-3	2005	Results of experiments of cell culture with rat osteosarcoma (ROS) cells demonstrated that RGDS immobilization could enhance the attachment of ROS cells onto the chitosan, resulting in higher cell density attached to the RGDS-modified scaffold than to the unmodified scaffold.	ros	143-146	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	91-95
15603814-3	2005	Results of experiments of cell culture with rat osteosarcoma (ROS) cells demonstrated that RGDS immobilization could enhance the attachment of ROS cells onto the chitosan, resulting in higher cell density attached to the RGDS-modified scaffold than to the unmodified scaffold.	ros	143-146	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	221-225
35052670-7	2022	Moreover, the behavior of organic nitrates with antioxidant properties supports the hypothesis of the involvement of ROS in inactivating ALDH-2.	ros	117-120	aldehyde dehydrogenase 2 family member	Homo sapiens	137-143
22652796-6	2012	Taken together, these results suggest that BMP2 induces the cell invasion of PANC-1 cells by enhancing MMP-2 secretion and acting through ROS accumulation and ERK activation.	ros	138-141	bone morphogenetic protein 2	Homo sapiens	43-47
22516817-9	2012	We conclude that the NFXL2-78 protein is part of a regulatory network that integrates the biosynthesis and action of ABA, ROS, and cuticle components.	ros	122-125	NF-X1-type zinc finger protein NFXL2	Arabidopsis thaliana	21-26
35052481-3	2022	In both female (cumulus-oocyte-complexes-COCs) and male (spermatozoa), oxidative stress was measured by CM-H2DCFDA assay and key ROS scavengers (SOD1, SOD2, GPX1, GPX4, CAT) were quantified at the mRNA and protein levels using qPCR and Western blot (COCs)/immunofluorescence (sperm).	ros	129-132	superoxide dismutase [Cu-Zn]	Bos taurus	145-149
15965085-8	2005	Our results suggest that suppression of ROS-mediated COX-2 expression by isovitexin is beneficial in reducing inflammation and carcinogenesis.	ros	40-43	prostaglandin-endoperoxide synthase 2	Mus musculus	53-58
35069734-10	2022	In addition, we found that, in PANC-1 cells under an acidic environment, miR-451a overexpression enhanced oxygen consumption, mitochondrial membrane potential (MMP) loss, and ROS generation and inhibited proliferation, migration, invasion, and stemness via sponging MEF2D.	ros	175-178	microRNA 451a	Homo sapiens	73-81
22386991-1	2012	We previously reported that C-terminal fragment of ADAMTS-18 induces platelet fragmentation through ROS release.	ros	100-103	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 18	Mus musculus	51-60
22001850-6	2012	By treatment of the cells with glycolysis inhibitors, an AMPK inhibitor or genetic knockdown of AMPK, respectively, the H(2)O(2)-induced increase of NADPH was abrogated leading to the overproduction of intracellular ROS and cell death.	ros	216-219	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	96-100
35069199-6	2021	We found that DUB blockade results in the accumulation of polyubiquitinated proteins and ROS production, associated with cofilin oxidation and dephosphorylation on serine 3, which provokes uncontrolled actin polymerization impairing cell migration.	ros	89-92	cofilin 1	Homo sapiens	121-128
35069199-7	2021	Together, our study highlights DUBs as novel regulators of actin dynamics through ROS-dependent cofilin modulation, and shows that DUBi represent attractive novel tools to impede leukemic cell migration.	ros	82-85	cofilin 1	Homo sapiens	96-103
35035671-0	2022	Forsythiaside A Regulates Activation of Hepatic Stellate Cells by Inhibiting NOX4-Dependent ROS.	ros	92-95	NADPH oxidase 4	Homo sapiens	77-81
35600154-0	2022	Scopoletin protects retinal ganglion cells 5 from high glucose-induced injury in a cellular model of diabetic retinopathy via ROS-dependent p38 and JNK signaling cascade.	ros	126-129	mitogen-activated protein kinase 14	Mus musculus	140-143
15545650-6	2005	The oxa1(ts) mutant exhibits severe defects in the respiratory complexes I and IV, which are correlated with an increased life span, a strong induction of the alternative oxidase, and a reduction in ROS production.	ros	199-202	OXA1L mitochondrial inner membrane protein	Homo sapiens	4-8
15765147-7	2005	We show that reduced levels of LANA lead to p53 reactivation, an increase in ROS, and mitochondrial dysfunction, which result in G1 cell cycle arrest, DNA fragmentation, and oxidative stress-mediated apoptosis.	ros	77-80	LANA	Human gammaherpesvirus 8	31-35
22251375-0	2012	Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes.	ros	80-83	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	121-125
15761253-6	2005	Increase of the ROS formation was also observed in the cells treated with TCDD in a dose-dependent and an AhR-dependent manner.	ros	16-19	aryl hydrocarbon receptor	Homo sapiens	106-109
35600154-9	2022	Overall, SPT exhibited a protective effect in RGC-5 cells exposed to a high-glucose environment via its antioxidant efficacy, inhibition of apoptosis and modulation of the ROS-dependent p38/JNK signaling cascade.	ros	172-175	mitogen-activated protein kinase 14	Mus musculus	186-189
35296207-2	2022	The purpose of this study was to investigate the role of NADPH oxidase (NOX) isoform NOX2-derived ROS in the regulation of ZIP2 expression, focusing on the role of the NOX2 cytosolic factor p67phox.	ros	98-101	cytochrome b-245, beta polypeptide	Mus musculus	85-89
21902595-5	2012	Moreover, regulation of Oct4 by Ago2 directly controls the stem cell plasticity-determining signal mediators JAK2/STAT3 and Wnt5A/beta-catenin and positively regulates cell proliferation and differentiation via blockage of ROS generation and P38/JNK inactivation.	ros	223-226	Janus kinase 2	Homo sapiens	109-113
21902595-8	2012	INNOVATION AND CONCLUSION: This study reveals that nuclear Ago2 globally controls stem cell self-renewal and differentiation through direct regulation of stemness genes and important signal mediator activation following inactivation of ROS/P38/JNK and activation of the JAK/STAT3 and Wnt/ beta-catenin signal pathways.	ros	236-239	Janus kinase 2	Homo sapiens	270-273
35129048-12	2022	In addition, siRNA-mediated UCP2 knockdown further aggravated mitochondrial fragmentation and DeltaPsim depolarization and increased mitochondrial ROS production and cell apoptosis in HS-induced HUVECs, which were abolished by Drp1 inhibition.	ros	147-150	uncoupling protein 2	Homo sapiens	28-32
22109951-2	2012	The concept of healthcare-associated pneumonia (HCAP) exists to help identify patients infected with ROs but may be overly broad.	ros	101-104	structural maintenance of chromosomes 3	Homo sapiens	15-46
15361071-7	2005	Importantly, addition of recombinant hnRNP K to ROS 17/2.8 nuclear extract disrupts formation of a DNA-protein complex on ds CT element oligonucleotides.	ros	48-51	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	37-44
15556616-0	2004	S100B-modulated Ca2+-dependent ROS-GC1 transduction machinery in the gustatory epithelium: a new mechanism in gustatory transduction.	ros	31-34	solute carrier family 25 member 22	Bos taurus	35-38
15556616-4	2004	The machinery is a two-component system: the Ca2+-sensor protein, S100B; and the transducer, ROS-GC1.	ros	93-96	solute carrier family 25 member 22	Bos taurus	97-100
22109951-2	2012	The concept of healthcare-associated pneumonia (HCAP) exists to help identify patients infected with ROs but may be overly broad.	ros	101-104	structural maintenance of chromosomes 3	Homo sapiens	48-52
22301971-5	2012	We suggest that TaCHP serve as both a transcription factor and a putative DAG binding protein to confer salt tolerance in part through improving ROS scavenging capacity; which is a component of the cross-talk machinery in the phospholipids-ROS-salt responsive signaling pathways.	ros	145-148	CHP	Triticum aestivum	16-21
15507765-1	2004	The NOX family of ROS-generating NADPH oxidases consists of 7 members: NOX1 to NOX5, DUOX1 and 2.	ros	18-21	NADPH oxidase 1	Homo sapiens	71-75
15507765-1	2004	The NOX family of ROS-generating NADPH oxidases consists of 7 members: NOX1 to NOX5, DUOX1 and 2.	ros	18-21	dual oxidase 1	Homo sapiens	85-96
15197348-5	2004	The reduction in cell growth and enhancement in cell killing by the combination of GST-MDA-7 and radiation were blocked by an ROS scavenger, N-acetyl cysteine (NAC), a JNK1/2/3 inhibitor SP600125, a pan-caspase inhibitor (zVAD) and by an inhibitor of caspase 9 (LEHD), but not by an inhibitor of caspase 8 (IETD).	ros	126-129	caspase 8	Homo sapiens	296-305
22301971-5	2012	We suggest that TaCHP serve as both a transcription factor and a putative DAG binding protein to confer salt tolerance in part through improving ROS scavenging capacity; which is a component of the cross-talk machinery in the phospholipids-ROS-salt responsive signaling pathways.	ros	240-243	CHP	Triticum aestivum	16-21
22829775-3	2012	Using a panel of GFP-fused stress response genes, we identified the suites of cytoprotective pathways upregulated by 160 gene inactivations known to increase Caenorhabditis elegans longevity, including the mitochondrial UPR (hsp-6, hsp-60), the ER UPR (hsp-4), ROS response (sod-3, gst-4), and xenobiotic detoxification (gst-4).	ros	261-264	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	275-280
22860102-4	2012	Combination treatment resulted in a significant enhancement of ROS production resulting in immense DNA damage, induction of autophagy analyzed by transmission electron microscope and increase in expression of autophagy marker LC3B, and culminated in cell death analyzed by cleaved caspase 3.	ros	63-66	microtubule associated protein 1 light chain 3 beta	Homo sapiens	226-230
22039262-7	2011	Treatment with the cytokine G-CSF improved HSPC survival after exposure to oxidative stress and rescued the transplantation defect in Nrf2(-/-) cells despite increases in ROS induced by cytokine signaling.	ros	171-174	colony stimulating factor 3 (granulocyte)	Mus musculus	28-33
21861192-7	2011	ROS inhibition prevented p73 and Noxa expression but not p53 and p21 expression, suggesting a role for Noxa in p53-independent apoptosis in melanoma cells.	ros	0-3	tumor protein p73	Homo sapiens	25-28
22041887-8	2011	In coculture, tamoxifen induces the upregulation of TIGAR (TP53-induced glycolysis and apoptosis regulator), a p53 regulated gene that simultaneously inhibits glycolysis, autophagy and apoptosis and reduces ROS generation, thereby promoting oxidative mitochondrial metabolism.	ros	207-210	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	52-57
22041887-8	2011	In coculture, tamoxifen induces the upregulation of TIGAR (TP53-induced glycolysis and apoptosis regulator), a p53 regulated gene that simultaneously inhibits glycolysis, autophagy and apoptosis and reduces ROS generation, thereby promoting oxidative mitochondrial metabolism.	ros	207-210	TP53 induced glycolysis regulatory phosphatase	Homo sapiens	59-106
21815883-3	2011	We have generated a stable cell line F-HABP07, by constitutively overexpressing human Hyaluronan Binding Protein1 (HABP1) in murine fibroblasts which accumulates in the mitochondria leading to excess ROS generation without any external stimuli.	ros	200-203	complement C1q binding protein	Homo sapiens	86-113
21815883-3	2011	We have generated a stable cell line F-HABP07, by constitutively overexpressing human Hyaluronan Binding Protein1 (HABP1) in murine fibroblasts which accumulates in the mitochondria leading to excess ROS generation without any external stimuli.	ros	200-203	complement C1q binding protein	Homo sapiens	115-120
21815883-4	2011	In the present study, we demonstrated the nuclear translocation of p65 subunit of NF-kappaB in F-HABP07 cells, an important signature of ROS induced signalling cascade providing us an opportunity to use it as a screening system for ROS scavengers.	ros	137-140	RELA proto-oncogene, NF-kB subunit	Homo sapiens	67-91
21815883-4	2011	In the present study, we demonstrated the nuclear translocation of p65 subunit of NF-kappaB in F-HABP07 cells, an important signature of ROS induced signalling cascade providing us an opportunity to use it as a screening system for ROS scavengers.	ros	232-235	RELA proto-oncogene, NF-kB subunit	Homo sapiens	67-91
21499310-4	2011	The effects of LXA(4), ANXA1, SAA and LL-37 were dependent on the activation of their mutual cell-surface receptor formyl peptide receptor-2 (FPR2) and subsequent ROS-MAPK-NF-kB signalings.	ros	163-166	annexin A1	Mus musculus	23-28
21683690-0	2011	SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.	ros	32-35	small ubiquitin like modifier 1	Homo sapiens	0-5
21683690-4	2011	Intriguingly, SUMO1 conjugation resulted in decrease of intracellular ROS generation and protection cells from death under heat-shock stress.	ros	70-73	small ubiquitin like modifier 1	Homo sapiens	14-19
21683690-7	2011	These results suggested that SUMO1 plays an important role in modulation of NOX activity required for ROS generation.	ros	102-105	small ubiquitin like modifier 1	Homo sapiens	29-34
21549813-10	2011	Taken together, these results suggest that the signals of ROS-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic pathways that are involved in MeHg-induced neurotoxicity.	ros	58-61	mitogen-activated protein kinase 3	Mus musculus	71-77
21549813-10	2011	Taken together, these results suggest that the signals of ROS-mediated ERK1/2 and p38 activation regulated mitochondria-dependent apoptotic pathways that are involved in MeHg-induced neurotoxicity.	ros	58-61	mitogen-activated protein kinase 14	Mus musculus	82-85
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	p21 (RAC1) activated kinase 1	Homo sapiens	211-214
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	p21 (RAC1) activated kinase 1	Homo sapiens	211-214
21291390-9	2011	However sub-lethal increases in ROS can activate hypertrophic signaling kinases and transcription factors including NFAT, CaMK and serine-threonine and tyrosine kinases.	ros	32-35	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	122-126
21480341-7	2011	Mechanistically, CD13 reduced ROS-induced DNA damage after genotoxic chemo/radiation stress and protected cells from apoptosis.	ros	30-33	alanyl aminopeptidase, membrane	Homo sapiens	17-21
21445297-4	2011	By exacerbating ROS production in response to cisplatin, Bmi-1 silencing activates the DNA damage response pathway, caspases and cleaves PARP resulting in the induction apoptosis in ovarian cancer cells.	ros	16-19	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	57-62
20574010-17	2010	CONCLUSIONS: These results indicate that the generation of intralysosomal ROS induces lysosomal membrane permeabilization and the release of cathepsin D into the cytosol, leading to TM cell death.	ros	74-77	cathepsin D	Homo sapiens	141-152
20802255-11	2010	CONCLUSIONS: Adiponectin prevents EPC senescence by inhibiting the ROS/p38 MAPK/p16(INK4A) signaling cascade.	ros	67-70	mitogen-activated protein kinase 14	Mus musculus	71-79
20978343-7	2010	The importance of this pathway was evidenced by increased ROS generation in prdx2-/- mice and decreased thrombosis times in both prdx2-/- and nrf2-/- mice after vascular injury.	ros	58-61	peroxiredoxin 2	Mus musculus	76-81
20705126-6	2010	In mouse cardiac fibroblasts, bread crust extract induced a moderate elevation of ROS production causing an activation of p42/p44(MAPK), p38(MAPK) and NF-kappaB, followed by increased expression of antioxidative enzymes.	ros	82-85	cyclin-dependent kinase 20	Mus musculus	122-125
20705126-6	2010	In mouse cardiac fibroblasts, bread crust extract induced a moderate elevation of ROS production causing an activation of p42/p44(MAPK), p38(MAPK) and NF-kappaB, followed by increased expression of antioxidative enzymes.	ros	82-85	mitogen-activated protein kinase 14	Mus musculus	137-140
15075348-0	2004	Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions.	ros	84-87	S100 calcium binding protein A8	Homo sapiens	34-40
20638939-0	2010	Disruption of Sag/Rbx2/Roc2 induces radiosensitization by increasing ROS levels and blocking NF-kappaB activation in mouse embryonic stem cells.	ros	69-72	ring finger protein 7	Mus musculus	18-22
20595066-7	2010	Additionally, inhibition of uncoupling protein-2 (UCP2) caused cytotoxicity in colon cancer cells via ROS of mitochondrial origin.	ros	102-105	uncoupling protein 2	Homo sapiens	28-48
12938168-0	2003	TRPC3-like protein is involved in the capacitative cation entry induced by 1alpha,25-dihydroxy-vitamin D3 in ROS 17/2.8 osteoblastic cells.	ros	109-112	transient receptor potential cation channel, subfamily C, member 3	Rattus norvegicus	0-5
12938168-5	2003	In ROS 17/2.8 cells intranuclearly microinjected with anti-TRPC3 antisense oligodeoxynucleotides (ODN), both the initial rate and magnitude of CCE activated by either 1alpha,25(OH)(2)D3 or Tpg were markedly reduced, whereas no changes were detected in control-injected cells.	ros	3-6	transient receptor potential cation channel, subfamily C, member 3	Rattus norvegicus	59-64
20595066-7	2010	Additionally, inhibition of uncoupling protein-2 (UCP2) caused cytotoxicity in colon cancer cells via ROS of mitochondrial origin.	ros	102-105	uncoupling protein 2	Homo sapiens	50-54
12880425-5	2003	Generation of ROS and hyperpolarization of mitochondrial transmembrane potential (DeltaPsim) were early events, followed by increased Fas expression and activation of caspase-8, and then activation of caspase-3 and -9.	ros	14-17	caspase 8	Homo sapiens	167-176
20462348-5	2010	Ligand-receptor interaction triggers a signalling cascade leading to ROS production, which in turn enhances expression and activity of Ecto-NOX1.	ros	69-72	tripartite motif containing 33	Homo sapiens	135-139
12733958-6	2003	RESULTS: The ROS 17/2.8 cells transfected with antisense Tbx2 showed a decrease in expression of Tbx2 protein and an increase in expression of endogenous Cx43.	ros	13-16	T-box transcription factor 2	Rattus norvegicus	57-61
12733958-6	2003	RESULTS: The ROS 17/2.8 cells transfected with antisense Tbx2 showed a decrease in expression of Tbx2 protein and an increase in expression of endogenous Cx43.	ros	13-16	T-box transcription factor 2	Rattus norvegicus	97-101
14695935-2	2003	CoQ1 was shown to prevent ROS formation and cell death in complex 1 inhibited cells.	ros	26-29	decaprenyl diphosphate synthase subunit 1	Homo sapiens	0-4
14695935-3	2003	Low concentrations of capsaicin like CoQ1 inhibited ROS formation but CoQ1 was more effective at restoring the mitochondrial membrane potential collapse caused by complex 1 inhibitors such as rotenone.	ros	52-55	decaprenyl diphosphate synthase subunit 1	Homo sapiens	37-41
20462348-5	2010	Ligand-receptor interaction triggers a signalling cascade leading to ROS production, which in turn enhances expression and activity of Ecto-NOX1.	ros	69-72	NADPH oxidase 1	Homo sapiens	140-144
20630072-4	2010	RESULTS: The profound control of AuNPs over the anti oxidant enzymes such as GSH, SOD, Catalase and GPx in diabetic mice to normal, by inhibition of lipid peroxidation and ROS generation during hyperglycemia evidence their anti-oxidant effect during hyperglycemia.	ros	172-175	peroxiredoxin 6 pseudogene 2	Mus musculus	100-103
20138821-5	2010	VDAC1 and 2 are able to complement the lack of porin in mitochondrial respiration and modulation of ROS.	ros	100-103	voltage dependent anion channel 1	Homo sapiens	0-11
12110433-2	2002	We have shown previously that ROS 17/2.8 cells show increased activation of ERK-1 or -2, which is sustained for 24 h, when the strips onto which they are seeded are subjected to a 10 min period of cyclic four point bending that produces physiological levels of mechanical strain along with associated fluid movement of the medium.	ros	30-33	mitogen activated protein kinase 3	Rattus norvegicus	76-87
20230789-0	2010	Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation.	ros	90-93	NADPH oxidase activator 1	Mus musculus	32-57
12110433-5	2002	Our present study investigates the role of components of signaling pathways in the activation of ERK-1/2 in ROS 17/2.8 cells in response to these stimuli.	ros	108-111	mitogen activated protein kinase 3	Rattus norvegicus	97-104
20498758-12	2010	Furthermore, early introduction of these two Runx2 and MEF factors significantly elevated the expression of the Opn mRNA levels in ROS cells.	ros	131-134	secreted phosphoprotein 1	Rattus norvegicus	112-115
19744503-7	2010	Up-regulation of DMT1-IRE by MPP+ treatment was associated with ROS production and translocation of nuclear factor-kappaB (NF-kappaB) to nuclei, both of which were significantly inhibited by Rg1 pretreatment.	ros	64-67	protein phosphatase 1, regulatory subunit 3A	Mus musculus	191-194
11996904-5	2002	We found that 10 nmol/L PTH maximally induced RGS-2 mRNA in murine MC3T3-E1 cells, rat Py1a and ROS-17/2.8 cells, primary mouse osteoblasts (MOB cells), and mouse calvariae organ culture at 1-2 h posttreatment.	ros	96-99	parathyroid hormone	Mus musculus	24-27
11423121-3	2001	Activation of p38MAPK occurs late, coincident with the maximal production of ROS, it is inhibited by radical scavengers and it is accentuated by the presence of glutathione synthesis inhibitors.	ros	77-80	mitogen activated protein kinase 14	Rattus norvegicus	14-21
19744503-10	2010	These results indicate that Rg1 protected the MPP+-treated MES23.5 cells via attenuating DMT1-IRE up-regulation likely through inhibition of ROS-NF-kappaB pathway; Attenuation of DMT1-IRE expression decreased the iron influx and iron-induced oxidative stress.	ros	141-144	protein phosphatase 1, regulatory subunit 3A	Mus musculus	28-31
19892012-11	2010	These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.	ros	43-46	MYD88 innate immune signal transduction adaptor	Homo sapiens	88-93
19850939-6	2009	This was associated with an increased ability of Ang II to stimulate NADPH oxidase-reactive oxygen species (ROS)-mediated signaling involving phosphorylation of the p47phox subunit of the NADPH oxidase and was dependent on the activation of PI3K in the SHR.	ros	108-111	neutrophil cytosolic factor 1	Rattus norvegicus	165-172
11268282-6	2001	Furthermore, it was shown by direct comparison that ILP with IG.Ad.CMV.rIL-3 beta in the ROS-1 osteosarcoma model is at least as efficient as the established therapy with the combination of TNF-alpha and melphalan.	ros	89-92	interleukin 3	Rattus norvegicus	71-76
11266449-4	2001	Ros and SHP-1 are coexpressed in epididymal epithelium, and elevated phosphorylation of Ros in the epididymis of me(v) mice suggests that Ros signaling is under control of SHP-1 in vivo.	ros	88-91	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	172-177
11266449-4	2001	Ros and SHP-1 are coexpressed in epididymal epithelium, and elevated phosphorylation of Ros in the epididymis of me(v) mice suggests that Ros signaling is under control of SHP-1 in vivo.	ros	88-91	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	172-177
11266449-5	2001	Phosphorylated Ros strongly and directly associates with SHP-1 in yeast two-hybrid, glutathione S-transferase pull-down, and coimmunoprecipitation experiments.	ros	15-18	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	57-62
19715769-7	2009	Citrate synthase activity was assayed and found enriched in disks with respect to ROS.	ros	82-85	citrate synthase	Homo sapiens	0-16
11266449-6	2001	Strong binding of SHP-1 to Ros is selective compared to six other receptor tyrosine kinases.	ros	27-30	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	18-23
11266449-8	2001	Overexpression of SHP-1 results in Ros dephosphorylation and effectively downregulates Ros-dependent proliferation and transformation.	ros	35-38	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	18-23
11266449-8	2001	Overexpression of SHP-1 results in Ros dephosphorylation and effectively downregulates Ros-dependent proliferation and transformation.	ros	87-90	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	18-23
11266449-9	2001	We propose that SHP-1 is an important downstream regulator of Ros signaling.	ros	62-65	protein tyrosine phosphatase, non-receptor type 6	Mus musculus	16-21
10430646-8	1999	In vitro, ROS 17/2.8 cells expressed detectable levels of c-fos, c-jun, c-myc, OC, OP, ALP, COL1A1, and PTHR but not MMP-9.	ros	10-13	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	72-77
19920349-7	2009	Adoptive transfer of Ccr2+/+ monocytes into Ccr2-/- mice resulted in selective monocyte uptake into the ascending and suprarenal aorta in regions of enhanced ROS stress, with restoration of IL-6 secretion and increased incidence of dissection.	ros	158-161	chemokine (C-C motif) receptor 2	Mus musculus	21-25
10430646-8	1999	In vitro, ROS 17/2.8 cells expressed detectable levels of c-fos, c-jun, c-myc, OC, OP, ALP, COL1A1, and PTHR but not MMP-9.	ros	10-13	secreted phosphoprotein 1	Rattus norvegicus	83-85
19712206-7	2009	Further, MEN inhibition of Siah2 was not attenuated by free radical scavenger, suggesting it is ROS-independent.	ros	96-99	siah E3 ubiquitin protein ligase 2	Homo sapiens	27-32
10052930-6	1999	However, when stripped ROS membranes were reconstituted with both GCAP1 and either transducin (T alpha beta gamma) or the T beta gamma-subunits, the inhibition of ROS-GC by light was restored.	ros	23-26	guanylate cyclase 2D, retinal	Bos taurus	163-169
18544047-6	2009	Through suppressing the expression of another ERRalpha target gene pyruvate dehydrogenase kinase 2 (PDK2), we found that XCT-790 not only enhanced the conversion of pyruvate to acetyl-CoA and hyper-activated the tricarboxylic acid (TCA) cycle, but also led to higher levels of mitochondrial membrane potential and reactive oxidant species (ROS) production.	ros	340-343	pyruvate dehydrogenase kinase 2	Homo sapiens	100-104
9878167-5	1998	Tat induced a progressive elevation of cytoplasmic-free calcium levels, which was followed by mitochondrial calcium uptake and generation of mitochondrial-reactive oxygen species (ROS).	ros	180-183	tyrosine aminotransferase	Homo sapiens	0-3
9878167-7	1998	zVAD-fmk suppressed Tat-induced increases of cytoplasmic calcium levels and mitochondrial ROS accumulation, indicating roles for caspases in the perturbed calcium homeostasis and oxidative stress induced by Tat.	ros	90-93	tyrosine aminotransferase	Homo sapiens	20-23
9878167-10	1998	Collectively, our data demonstrate that Tat can induce neuronal apoptosis by a mechanism involving disruption of calcium homeostasis, caspase activation, and mitochondrial calcium uptake and ROS accumulation.	ros	191-194	tyrosine aminotransferase	Homo sapiens	40-43
19847116-5	2009	Genetic, molecular and biochemical analyses suggest that dry2/sqe1-5 defective phenotypes cannot be simply explained by a depletion of bulk sterols but rather by altered ROS.	ros	170-173	FAD/NAD(P)-binding oxidoreductase family protein	Arabidopsis thaliana	62-68
19061439-9	2009	The potential signal peptide of Nox1 failed to translocate Nox4 to the plasma membrane but switched the extracellularly detectable ROS from H(2)O(2) to O(2)(-).	ros	131-134	NADPH oxidase 1	Homo sapiens	32-36
9693379-5	1998	Transfection of Cx45 in cells that express primarily Cx43 (ROS 17/2.8 and MC3T3-E1) decreased both dye transfer and expression of osteocalcin (OC) and bone sialoprotein (BSP), genes pivotal to bone matrix formation and calcification.	ros	59-62	gap junction protein, gamma 1	Rattus norvegicus	16-20
19428456-10	2009	The simplest explanation of our results is that clk-1 mitochondria scavenge ROS more effectively than wildtype due to the presence of DMQ(9).	ros	76-79	5-demethoxyubiquinone hydroxylase, mitochondrial	Caenorhabditis elegans	48-53
19323941-11	2009	CONCLUSION: CyPA may act as an ROS scavenger, and prevent Abeta(25-35)-induced neurotoxicity through attenuating oxidative stress induced by Abeta(25-35).	ros	31-34	peptidylprolyl isomerase A	Rattus norvegicus	12-16
9558335-4	1998	Untransfected rat osteosarcoma cells (ROS 17/2.8) treated with 1,25(OH)2D3 showed a 2-fold increase in NGF expression compared to control cells.	ros	38-41	nerve growth factor	Rattus norvegicus	103-106
19191108-0	2009	Serotonin binds to purified neuronal nitric oxide synthase: a possible explanation for ROS production induced by 5HT in the presence of nNOS.	ros	87-90	nitric oxide synthase 1	Homo sapiens	28-58
9628323-10	1998	Two phases of intracellular ROS generation in TGF-beta1-treated cultures were observed: the first (rapid, 60 min after TGF-beta1 administration), and the second (slow, occurring between 24 and 48h of experiment, respectively).	ros	28-31	transforming growth factor, beta 1	Mus musculus	46-55
9628323-10	1998	Two phases of intracellular ROS generation in TGF-beta1-treated cultures were observed: the first (rapid, 60 min after TGF-beta1 administration), and the second (slow, occurring between 24 and 48h of experiment, respectively).	ros	28-31	transforming growth factor, beta 1	Mus musculus	119-128
9546582-6	1998	The ERK1 activation was greater than the ERK2 in ROS 17/2.8 cells.	ros	49-52	mitogen activated protein kinase 3	Rattus norvegicus	4-8
9546582-6	1998	The ERK1 activation was greater than the ERK2 in ROS 17/2.8 cells.	ros	49-52	mitogen activated protein kinase 1	Rattus norvegicus	41-45
19191108-0	2009	Serotonin binds to purified neuronal nitric oxide synthase: a possible explanation for ROS production induced by 5HT in the presence of nNOS.	ros	87-90	nitric oxide synthase 1	Homo sapiens	136-140
19191108-1	2009	Serotonin (5HT) was shown to induce in vitro the production of ROS in the presence of neuronal nitric oxide synthase (nNOS) in addition to the basal NO(+) formation.	ros	63-66	nitric oxide synthase 1	Homo sapiens	86-116
19191108-1	2009	Serotonin (5HT) was shown to induce in vitro the production of ROS in the presence of neuronal nitric oxide synthase (nNOS) in addition to the basal NO(+) formation.	ros	63-66	nitric oxide synthase 1	Homo sapiens	118-122
19191108-5	2009	The formation of 5HT-nNOS complex was shown to be very well correlated with the production of ROS by 5HT in the presence of nNOS.	ros	94-97	nitric oxide synthase 1	Homo sapiens	21-25
19191108-5	2009	The formation of 5HT-nNOS complex was shown to be very well correlated with the production of ROS by 5HT in the presence of nNOS.	ros	94-97	nitric oxide synthase 1	Homo sapiens	124-128
8725179-6	1996	Nucleotide sequence of PCR fragments from ROS 17/2.8 cells revealed 100% identity with rat brain beta ARK1 and beta-arrestin 1 sequences.	ros	42-45	G protein-coupled receptor kinase 2	Rattus norvegicus	97-106
19191108-6	2009	A mechanism involving nNOS only in its initial step is proposed to explain both the formation of 5HT-nNOS complex and the production of ROS observed in the presence of nNOS and 5HT.	ros	136-139	nitric oxide synthase 1	Homo sapiens	22-26
8634257-4	1996	We have characterized the hydrodynamic properties of Triton X-100 solubilized peripherin/rds-rom-1 complexes from bovine ROS membranes by gel exclusion chromatography on Sepharose C1-6B and velocity sedimentation through H2O- and D2O-based sucrose gradients.	ros	121-124	peripherin 2	Bos taurus	89-92
19191108-6	2009	A mechanism involving nNOS only in its initial step is proposed to explain both the formation of 5HT-nNOS complex and the production of ROS observed in the presence of nNOS and 5HT.	ros	136-139	nitric oxide synthase 1	Homo sapiens	101-105
8634257-8	1996	The abundance of this complex as measured by competitive ELISA and immunoaffinity purification is approximately 4% of total bovine ROS membrane protein and indicates that peripherin/rds-rom-1 tetramers are present at a relatively high average surface density (ca.	ros	131-134	peripherin 2	Bos taurus	182-185
19191108-6	2009	A mechanism involving nNOS only in its initial step is proposed to explain both the formation of 5HT-nNOS complex and the production of ROS observed in the presence of nNOS and 5HT.	ros	136-139	nitric oxide synthase 1	Homo sapiens	101-105
8612540-8	1996	Our results demonstrate that Fra-2 is hyperphosphorylated upon TGF-beta 1 treatment of ROS 17/2.8 cells.	ros	87-90	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	29-34
19137062-4	2009	Under these conditions, PS1/PS2 double-knockout MEFs showed aberrant accumulation of phospho-beta-catenin, higher ROS generation, and notable cell death.	ros	114-117	presenilin 1	Homo sapiens	24-27
8612540-10	1996	Together, these results demonstrate that TGF-beta 1 responsiveness of the rat osteocalcin gene in ROS 17/2.8 cells is mediated through an activator protein-1 like cis-acting element that interacts with Fra-2.	ros	98-101	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	138-157
8612540-10	1996	Together, these results demonstrate that TGF-beta 1 responsiveness of the rat osteocalcin gene in ROS 17/2.8 cells is mediated through an activator protein-1 like cis-acting element that interacts with Fra-2.	ros	98-101	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	202-207
19007111-3	2008	The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21.	ros	112-115	H2A.X variant histone	Homo sapiens	185-189
8615881-2	1996	In addition, KCA-098 increased the synthesis of collagenese-digestible protein (CDP) of ROS 17/2.8 cells.	ros	88-91	cut-like homeobox 1	Rattus norvegicus	48-78
8615881-2	1996	In addition, KCA-098 increased the synthesis of collagenese-digestible protein (CDP) of ROS 17/2.8 cells.	ros	88-91	cut-like homeobox 1	Rattus norvegicus	80-83
18829485-4	2008	Expression of manganese superoxide dismutase (SOD2), which regulates cellular ROS, is markedly down-regulated in CRPC when compared with hormone-responsive tumors.	ros	78-81	superoxide dismutase 2	Homo sapiens	46-50
18829485-6	2008	RESULTS: SOD2 knockdown results in an increase in ROS.	ros	50-53	superoxide dismutase 2	Homo sapiens	9-13
18829485-8	2008	The induction of many of these genes with SOD2 knockdown, such as VEGFA and FKBP5, is reversible with the antioxidant N-acetylcysteine, suggesting that this mechanism is directly linked to ROS.	ros	189-192	superoxide dismutase 2	Homo sapiens	42-46
18829485-11	2008	CONCLUSIONS: These findings show that down-regulation of SOD2 induces AR activity in a ROS-dependent manner, and suggest that there may be a role for antioxidant therapy in CRPC.	ros	87-90	superoxide dismutase 2	Homo sapiens	57-61
18579341-10	2008	Similar inhibitions of ROS formation were also observed in PC12 cells pretreated with the classical dopamine transporter inhibitor of GBR-12909 and the MAO inhibitor L-deprenyl.	ros	23-26	solute carrier family 6 member 3	Rattus norvegicus	100-120
7641846-8	1995	The level of PE N-Mtase activity in the purified ROS preparation obtained from crude ROS fractions by discontinuous sucrose gradient centrifugation, was as high as 65% of the level found in the microsomal fraction obtained from the remainder of the retinas.	ros	49-52	phosphatidylethanolamine N-methyltransferase	Bos taurus	13-23
7641846-8	1995	The level of PE N-Mtase activity in the purified ROS preparation obtained from crude ROS fractions by discontinuous sucrose gradient centrifugation, was as high as 65% of the level found in the microsomal fraction obtained from the remainder of the retinas.	ros	85-88	phosphatidylethanolamine N-methyltransferase	Bos taurus	13-23
7641846-16	1995	When ROS membranes were selectively depleted of soluble or peripheral and soluble proteins, the PE N-MTase activity remained mainly associated to the membrane, suggesting that this enzyme (s) is an intrinsic membrane protein.	ros	5-8	phosphatidylethanolamine N-methyltransferase	Bos taurus	96-106
18579341-10	2008	Similar inhibitions of ROS formation were also observed in PC12 cells pretreated with the classical dopamine transporter inhibitor of GBR-12909 and the MAO inhibitor L-deprenyl.	ros	23-26	monoamine oxidase A	Rattus norvegicus	152-155
18617267-6	2008	Together, these findings suggest that APE/Ref-1 could act as a negative regulator in an adaptive response to elevated ROS levels following CD40 cross-linking.	ros	118-121	apurinic/apyrimidinic endonuclease 1	Mus musculus	38-41
7760823-5	1995	In contrast, BMP-2 rapidly reduces TGF-beta binding to betaglycan and type II receptors in osteoblast-enriched primary cell cultures and increases its relative binding to type I receptors in these cells and in ROS 17/2.8 cultures.	ros	210-213	bone morphogenetic protein 2	Rattus norvegicus	13-18
18617267-6	2008	Together, these findings suggest that APE/Ref-1 could act as a negative regulator in an adaptive response to elevated ROS levels following CD40 cross-linking.	ros	118-121	apurinic/apyrimidinic endonuclease 1	Mus musculus	42-47
8501053-6	1993	A mutation in ros causes the constitutive expression of virC and virD in the complete absence of the VirG protein.	ros	14-17	two-component response regulator VirG	Agrobacterium tumefaciens	101-105
18617267-6	2008	Together, these findings suggest that APE/Ref-1 could act as a negative regulator in an adaptive response to elevated ROS levels following CD40 cross-linking.	ros	118-121	CD40 antigen	Mus musculus	139-143
8501053-10	1993	DNase I footprint analysis showed that the Ros box overlaps the binding site of VirG (Vir box).	ros	43-46	two-component response regulator VirG	Agrobacterium tumefaciens	80-84
18617267-7	2008	Considering the important role of ROS and APE/Ref-1 in CD40-mediated B cell proliferation, our data will contribute to understand the mechanisms of tumor escape and suggest APE/Ref-1 as a novel target for tumor therapeutic approaches.	ros	34-37	CD40 antigen	Mus musculus	55-59
18289679-7	2008	Rac1 was responsible for increased ROS, and NADPH oxidase was the main source for ROS.	ros	35-38	Rac family small GTPase 1	Rattus norvegicus	0-4
1384276-10	1992	In the osteoblastic osteosarcoma cell line of rat, ROS 17/2.8, NE (0.1 microM) caused a significant stimulatory action on cyclic AMP formation that was synergistically potentiated by forskolin (3 microM), VIP, CGRP, and SP did not affect the cellular content of cyclic AMP in ROS 17/2.8.	ros	51-54	calcitonin-related polypeptide alpha	Rattus norvegicus	210-214
1644867-10	1992	In contrast, proliferating rat osteosarcoma cells (ROS 17/2.8) concomitantly express histone H4, along with osteopontin and osteocalcin.	ros	51-54	secreted phosphoprotein 1	Rattus norvegicus	108-119
18289679-7	2008	Rac1 was responsible for increased ROS, and NADPH oxidase was the main source for ROS.	ros	82-85	Rac family small GTPase 1	Rattus norvegicus	0-4
18289679-9	2008	ERK, p38 MAPK, and ROS, were responsible for secretion of beta-hexosaminidase, histamine release, and induction of chemokines.	ros	19-22	O-GlcNAcase	Rattus norvegicus	58-77
18202716-6	2008	While not correcting the gene defect, indirect gene therapy using antioxidant enzymes may be of help in limiting photosensitivity in XPC and probably in other monogenic/polygenic photosensitive disorders characterized by ROS accumulation.	ros	221-224	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	133-136
1585373-0	1992	Lead perturbs epidermal growth factor (EGF) modulation of intracellular calcium metabolism and collagen synthesis in clonal rat osteoblastic (ROS 17/2.8) cells.	ros	142-145	epidermal growth factor like 1	Rattus norvegicus	14-37
1585373-0	1992	Lead perturbs epidermal growth factor (EGF) modulation of intracellular calcium metabolism and collagen synthesis in clonal rat osteoblastic (ROS 17/2.8) cells.	ros	142-145	epidermal growth factor like 1	Rattus norvegicus	39-42
1585373-3	1992	Lead is known to interact with and perturb normal calcium signaling pathways; therefore, the purpose of this work was to determine if lead perturbs EGF modulation of calcium metabolism in ROS 17/2.8 cells and if lead impairs collagen synthesis, which is controlled by EGF.	ros	188-191	epidermal growth factor like 1	Rattus norvegicus	148-151
1309253-1	1992	The human insulinlike growth factor 1 (hIGF-1) receptor (hIGFR) is a transmembrane protein tyrosine kinase (PTK) molecule which shares high sequence homology in the PTK domain with the insulin receptor and, to a lesser degree, the ros transforming protein of avian sarcoma virus UR2.	ros	93-96	insulin receptor	Homo sapiens	185-201
17980396-9	2008	Pretreatment with cell-permeable catalase, N-acetyl-L-cysteine or GSH-monoethyl ester markedly reduced expression of NQO-1 and GCLC under HOCl challenge conditions, suggesting intracellular ROS-scavenging capacity affects HOCl-induced Nrf2 activation.	ros	190-193	glutamate-cysteine ligase catalytic subunit	Homo sapiens	127-131
1863811-3	1991	In contrast, a 44 kDa form was the major [32PO4]-labelled SPP-1 synthesized by a rat osteocarcoma cell line (ROS 17/2.8 cells) with lesser amounts of the 55 kDa SPP-1.	ros	109-112	secreted phosphoprotein 1	Rattus norvegicus	58-63
17913704-4	2007	Neutralizing anti-TNFR2 antibodies exacerbated TNFalpha responses on ROS production and cell death, arguing for a major protective role of the TNFR2 pathway.	ros	69-72	TNF receptor superfamily member 1B	Rattus norvegicus	18-23
1725676-8	1991	In an in vitro study of osteoblastic cells (UMR 106-01, ROS 17/2.8, Saos-2, MC3T3-E1) receptors to CGRP, VIP, noradrenaline (NA) and NPY were demonstrated as assessed by analysis of cyclic AMP formation.	ros	56-59	calcitonin-related polypeptide alpha	Rattus norvegicus	99-103
17616020-13	2007	A time-dependent variation has been observed in the levels of surfactant proteins A and D following paraquat injury, and it has been suggested that these proteins play a role in the protection of lung tissue against ROS-induced injuries.	ros	216-219	cysteine-rich secretory protein 3	Rattus norvegicus	73-89
17318262-9	2007	Second, Akt can induce expression of the ROS-generating enzyme NOX4.	ros	41-44	NADPH oxidase 4	Homo sapiens	63-67
2133741-12	1990	These results suggested that ICF stimulated the synthesis of TGF-beta and osteopontin in ROS 17/2.8 cells and that the osteopontin synthesis could be regulated by TGF-beta.	ros	89-92	secreted phosphoprotein 1	Rattus norvegicus	74-85
16762411-8	2006	These results suggest that in M07e cells calmodulin and CAMKII are involved in GLUT1 stimulation by cytokines and ROS.	ros	114-117	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	56-62
33820875-10	2021	These data showed that hepcidin protected osteoporosis by reducing iron levels in bone tissue, and in conjunction with PGC-1beta, reduced ROS production and the number of mitochondria, thus inhibiting osteoclast differentiation and bone absorption.	ros	138-141	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	119-128
16581217-0	2006	Two components in pathogenic mechanism of mitochondrial ATPase deficiency: energy deprivation and ROS production.	ros	98-101	ATP synthase F1 subunit epsilon	Homo sapiens	42-62
33588234-9	2021	Mechanistic study found that CNTF overexpression upregulated NFE2-related factor 2 (Nrf2) antioxidant pathway, coupled with decreased ROS level in the cardiac tissues.	ros	134-137	ciliary neurotrophic factor	Mus musculus	29-33
16581217-3	2006	With the aim to elucidate how the low ATPase content affects mitochondrial energy provision and ROS production, we have investigated fibroblasts from patients with ATPase decrease to 10-30%.	ros	96-99	dynein axonemal heavy chain 8	Homo sapiens	38-44
33816313-0	2021	Cyclovirobuxine D Induces Apoptosis and Mitochondrial Damage in Glioblastoma Cells Through ROS-Mediated Mitochondrial Translocation of Cofilin.	ros	91-94	cofilin 1	Homo sapiens	135-142
16581217-8	2006	Our studies clearly demonstrate that low ATPase content and decreased mitochondrial ATP production lead to high values of DeltaPsim and are associated with activation of ROS generation by the mitochondrial respiratory chain.	ros	170-173	dynein axonemal heavy chain 8	Homo sapiens	41-47
16374775-3	2006	Results from the culture of rat osteosarcoma (ROS), osteoblastic-like cells, demonstrate that the immobilization of RGDS could effectively enhance the attachment of ROS cells on PLLA and increase the cell density in PLLA scaffolds.	ros	46-49	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	116-120
34843865-3	2022	Topoisomerase IIalpha inhibition was associated with ROS-mediated activation of ATM-Chk2 kinase axis in HCT116 p53WT cells, but not in HCT116 p53-/- cells displaying early Chk1 activation.	ros	53-56	checkpoint kinase 2	Homo sapiens	84-88
34808100-17	2022	Pharmacological and genetic inhibition of TRPV1 could significantly attenuate Ca2+ influx, ROS generation and apoptotic cell death induced by EVO exposure, while exogenous TRPV1 overexpression could augment the EVO-induced cytotoxicity.	ros	91-94	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
16374775-3	2006	Results from the culture of rat osteosarcoma (ROS), osteoblastic-like cells, demonstrate that the immobilization of RGDS could effectively enhance the attachment of ROS cells on PLLA and increase the cell density in PLLA scaffolds.	ros	165-168	ral guanine nucleotide dissociation stimulator	Rattus norvegicus	116-120
15792539-2	2005	Recent studies in vitro have demonstrated that TEGDMA induced GSH depletion and production of radical oxygen species (ROS) in human gingival fibroblasts (HGF) but the exact mechanism of these events remains unclear.	ros	118-121	hepatocyte growth factor	Homo sapiens	154-157
34740282-7	2022	CYP2C8 variants leading to decreased enzyme activity in substrate oxidation may enhance ROS production by reaction uncoupling, and thus, contribute to difficulties in orthodontic treatment and the risk of side effects of antiresorptive drugs.	ros	88-91	cytochrome P450 family 2 subfamily C member 8	Homo sapiens	0-6
34622942-0	2022	Cyclic helix B peptide promotes random-pattern skin flap survival via TFE3-mediated enhancement of autophagy and reduction of ROS levels.	ros	126-129	transcription factor binding to IGHM enhancer 3	Homo sapiens	70-74
15800925-8	2005	Our data with 8-isoprostane also indicates that COX-2 plays a major role in ROS production in LPS-activated microglia.	ros	76-79	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	48-53
34622942-11	2022	A decrease in the levels of TFE3 caused a reduction in autophagy flux and accumulation of ROS and eliminated the protective effect of CHBP.	ros	90-93	transcription factor binding to IGHM enhancer 3	Homo sapiens	28-32
34450372-8	2022	However, the significantly decreased of ape-1 and sod-3 expression indicated the disruption of ROS defense mechanism.	ros	95-98	Superoxide dismutase [Mn] 2, mitochondrial	Caenorhabditis elegans	50-55
15744494-5	2005	These results are in accordance with the ones recently obtained with transgenic plants overexpressing tAPX; altogether, they suggest that tAPX, besides the known ROS scavenging role, is also involved in the fine changes of H2O2 concentration during signaling events.	ros	162-165	thylakoidal ascorbate peroxidase	Arabidopsis thaliana	102-106
34871568-1	2022	Slc4a11 KO mice show significant corneal edema, altered endothelial morphology, and mitochondrial ROS at an early age without a decrease in endothelial cell density.	ros	98-101	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	0-7
34992716-4	2021	A set of processes leading to this outcome starts with the generation of ROS, attributed to the interaction of Pt with complex I of the mitochondrial respiratory chain, and spreads to involve Ca2+ mobilization from the ER/mitochondria pool, activation of CREB and AMPK, and inhibition of mTORC1.	ros	73-76	CREB regulated transcription coactivator 1	Mus musculus	288-294
34927394-11	2021	CONCLUSION: The cellular senescence induced by IL-4 through the ROS-p38 MAPK-p16INK4A pathway promoted fibrogenesis during IgG4-RS.	ros	64-67	interleukin 4	Rattus norvegicus	47-51
15744494-5	2005	These results are in accordance with the ones recently obtained with transgenic plants overexpressing tAPX; altogether, they suggest that tAPX, besides the known ROS scavenging role, is also involved in the fine changes of H2O2 concentration during signaling events.	ros	162-165	thylakoidal ascorbate peroxidase	Arabidopsis thaliana	138-142
15806174-0	2005	HSP25 inhibits radiation-induced apoptosis through reduction of PKCdelta-mediated ROS production.	ros	82-85	protein kinase C delta	Homo sapiens	64-72
15145956-8	2004	AP-1 is activated by cellular oxidative stress, and we have reported significant production of ROS by high glucose-cultured cells.	ros	95-98	jun proto-oncogene	Mus musculus	0-4
34949550-0	2022	NOX4 promotes mucosal barrier injury in inflammatory bowel disease by mediating macrophages M1 polarization through ROS.	ros	116-119	NADPH oxidase 4	Mus musculus	0-4
34949550-1	2022	NADPH oxidase 4 (NOX4) plays an important role in transporting electrons in the mitochondrial respiratory chain, which is also one major source of ROS.	ros	147-150	NADPH oxidase 4	Mus musculus	0-15
34949550-1	2022	NADPH oxidase 4 (NOX4) plays an important role in transporting electrons in the mitochondrial respiratory chain, which is also one major source of ROS.	ros	147-150	NADPH oxidase 4	Mus musculus	17-21
34949550-2	2022	This study investigates the mechanism by which NOX4 promotes the M1 polarization of intestinal macrophages in inflammatory bowel disease (IBD) through ROS.	ros	151-154	NADPH oxidase 4	Mus musculus	47-51
34949550-17	2022	NOX4 is capable of promoting M1 polarization of intestinal macrophages through ROS, thereby further aggravating the intestinal inflammation and mucosal barrier injury in IBD.	ros	79-82	NADPH oxidase 4	Homo sapiens	0-4
34941746-0	2021	Indoxyl Sulfate Contributes to mTORC1-Induced Renal Fibrosis via The OAT/NADPH Oxidase/ROS Pathway.	ros	87-90	CREB regulated transcription coactivator 1	Mus musculus	31-37
15158334-0	2004	Primary cirrhotic hepatocytes resist TGFbeta-induced apoptosis through a ROS-dependent mechanism.	ros	73-76	transforming growth factor, beta 1	Mus musculus	37-44
15158334-5	2004	In normal hepatocytes, TGFbeta-induced apoptosis occurred through a ROS-, MPT-, and caspase-dependent pathway.	ros	68-71	transforming growth factor, beta 1	Mus musculus	23-30
15158334-7	2004	After treatment with trolox, an antioxidant that reduced basal ROS activity, cirrhotic hepatocytes underwent apoptosis in response to TGFbeta treatment.	ros	63-66	transforming growth factor, beta 1	Mus musculus	134-141
34846489-0	2021	ROS-mediated liposomal dexamethasone: a new FA-targeted nanoformulation to combat rheumatoid arthritis via inhibiting iRhom2/TNF-alpha/BAFF pathways.	ros	0-3	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	135-139
34846489-8	2021	The anti-inflammatory mechanism of Dex@FA-ROS-Lips was further studied and it was found that it is possibly associated with the down-regulation of iRhom2 and the activation of the TNF-alpha/BAFF signaling pathway.	ros	42-45	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	190-194
15158334-9	2004	Cirrhotic hepatocyte resistance to TGFbeta-induced apoptosis is ROS-dependent and is a mechanism of dysregulated growth in the chronically inflamed liver.	ros	64-67	transforming growth factor, beta 1	Mus musculus	35-42
34846489-9	2021	Therefore, the integration of nanomedicines and the RA microenvironment using multifunctional Dex@FA-ROS-Lips shall be a novel RA treatment modality with full clinical potential, and based on the enhanced therapeutic effect, the signaling pathway of iRhom2/TNF-alpha/BAFF reasonably explained the mechanism of Dex@FA-ROS-Lips in anti-RA, which suggested a molecular target for RA therapy and other inflammatory diseases.	ros	101-104	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	267-271
12361722-7	2002	This data suggest that oxidative stress and the production of ROS/RNS function as physiological regulators of ERalpha and ERbeta expression.	ros	62-65	estrogen receptor 2	Homo sapiens	122-128
34846489-9	2021	Therefore, the integration of nanomedicines and the RA microenvironment using multifunctional Dex@FA-ROS-Lips shall be a novel RA treatment modality with full clinical potential, and based on the enhanced therapeutic effect, the signaling pathway of iRhom2/TNF-alpha/BAFF reasonably explained the mechanism of Dex@FA-ROS-Lips in anti-RA, which suggested a molecular target for RA therapy and other inflammatory diseases.	ros	317-320	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	267-271
11950237-14	2002	The plasma membrane enriched fractions (isolated at densities of 1.08 and 1.125 g ml(-1)) containing tagged peripherin/rds and the Delta10 mutant promoted membrane fusion with ROS plasma membrane vesicles.	ros	176-179	peripherin	Canis lupus familiaris	108-118
34506261-9	2021	Our results suggest that argon preconditioning inhibited the PDCD4/PTEN pathway via miR-21, thereby inhibiting ROS oxidative stress and preventing MI/R injury.	ros	111-114	programmed cell death 4	Homo sapiens	61-66
34478982-4	2021	Among these 7 Galpha genes, only neuronal RNAi knockdown of gsa-1, gpa-10, and goa-1 affected toxicity of PS-NPs in inducing ROS production and in decreasing locomotion behavior.	ros	125-128	Guanine nucleotide-binding protein G(o) subunit alpha	Caenorhabditis elegans	79-84
11739633-9	2001	In contrast, ROS osteoblastic cells, which differentially sort Cx43 and Cx46, did not form Cx43/Cx46 heteromers.	ros	13-16	gap junction protein alpha 1	Homo sapiens	63-67
34492628-9	2021	In BV2 cells, NOX2 expression was upregulated, corresponding to the production of ROS.	ros	82-85	cytochrome b-245, beta polypeptide	Mus musculus	14-18
34492628-11	2021	Treatment of apocynin, a NOX2 inhibitor, reduced ROS generation and reversed Tau phosphorylation and inflammation caused by CoNPs.	ros	49-52	cytochrome b-245, beta polypeptide	Mus musculus	25-29
34492628-12	2021	Thus, CoNPs induced ROS production, Tau phosphorylation and inflammation specially via NOX2 activation.	ros	20-23	cytochrome b-245, beta polypeptide	Mus musculus	87-91
34688609-0	2021	CPT2 downregulation triggers stemness and oxaliplatin resistance in colorectal cancer via activating the ROS/Wnt/beta-catenin-induced glycolytic metabolism.	ros	105-108	carnitine palmitoyltransferase 2	Homo sapiens	0-4
11313345-6	2001	Under the same conditions, Cx43 also was isolated with anti-Cx45 antiserum from Cx45-transfected ROS cells (ROS/Cx45 cells).	ros	97-100	gap junction protein alpha 1	Homo sapiens	27-31
34836795-6	2021	Subsequent studies carried out with 1-39 and 1A-38 showed that both compounds could reduce the production of ROS in the cells, probably through down-regulating NOX2 and its downstream targets, including TXNIP (thioredoxin-interacting protein) and NLRP3 (NOD-like receptor protein 3).	ros	109-112	cytochrome b-245, beta polypeptide	Mus musculus	160-164
11313345-6	2001	Under the same conditions, Cx43 also was isolated with anti-Cx45 antiserum from Cx45-transfected ROS cells (ROS/Cx45 cells).	ros	108-111	gap junction protein alpha 1	Homo sapiens	27-31
11313345-7	2001	Cx43 antiserum could also coprecipitate ZO-1 in the transfected and untransfected ROS cells.	ros	82-85	gap junction protein alpha 1	Homo sapiens	0-4
34481870-11	2021	MPP+ treatment inhibited cell viability, increased LDH release, apoptosis, and ROS generation, and reduced superoxide dismutase (SOD) activity in SH-SY5Y cells, which were abolished by genkwanin treatment.	ros	79-82	M-phase phosphoprotein 6	Homo sapiens	0-3
11313345-8	2001	Double label immunofluorescence studies showed that ZO-1, Cx43, and Cx45 colocalized at appositional membranes in ROS/Cx45 cells suggesting that all three proteins are normally associated in the cells.	ros	114-117	gap junction protein alpha 1	Homo sapiens	58-62
11312605-6	2001	These data suggest that apoptosis along with increased ROS production, revealed by anti-oxidant enzymes overexpression, may play an important role in the pathophysiology of mitochondrial diseases associated with COX deficiency.	ros	55-58	cytochrome c oxidase subunit 8A	Homo sapiens	212-215
34666128-6	2021	Treatment with baicalein could reversed the increased MDA and ROS levels, and the decreased GSH levels in MPP+-treated SH-SY5Y cells.	ros	62-65	M-phase phosphoprotein 6	Homo sapiens	106-109
11565190-4	2001	Also, NO synthase (NOS) inhibitor, NG-monomethyl-L-arginine is reported to induce a dose-dependent inhibitory effect on the proliferation of osteoblast-like cell lines MG63 and ROS 17/2.8, which indicate that NO may stimulate cell proliferation.	ros	177-180	nitric oxide synthase 1, neuronal	Mus musculus	6-17
34773804-0	2021	Two interaction proteins between AtPHB6 and AtSOT12 regulate plant salt resistance through ROS signaling.	ros	91-94	prohibitin 6	Arabidopsis thaliana	33-39
34873574-10	2021	APOE and CTSD genes were mainly enriched in the regulation of ROS and oxidative stress.	ros	62-65	cathepsin D	Homo sapiens	9-13
34830465-7	2021	Mechanistically, leptin-induced inflammasome activation is mediated via the axis of ROS production, ER stress, and autophagy.	ros	84-87	leptin	Rattus norvegicus	17-23
34797521-10	2022	CO-induced Ngb upregulation was independent on ROS signalling, but partially dependent on the transcriptional factor SP1.	ros	47-50	neuroglobin	Mus musculus	11-14
34730139-6	2021	These events decreased TGF-beta1-induced production of ROS.	ros	55-58	transforming growth factor, beta 1	Mus musculus	23-32
34520770-0	2021	TAD1822-7 induces ROS-mediated apoptosis of HER2 positive breast cancer by decreasing E-cadherin in an EphB4 dependent manner.	ros	18-21	EPH receptor B4	Homo sapiens	103-108
34520770-4	2021	Inhibition of HER2 or EphB4 is discovered to induce ROS-dependent apoptosis by decreasing E-cadherin expression in SKBR3 and MDA-MB-453 cells.	ros	52-55	EPH receptor B4	Homo sapiens	22-27
34520770-6	2021	Mechanistic investigation revealed that TAD blockades both EphB4 positive signal transduction and activation of HER2 signal transduction, thereby suppressing E-cadherin/TGF-beta/p-Smad2/3 signaling axis to elicit ROS-dependent endogenous mitochondrial apoptosis.	ros	213-216	transforming growth factor alpha	Homo sapiens	169-177
34520770-6	2021	Mechanistic investigation revealed that TAD blockades both EphB4 positive signal transduction and activation of HER2 signal transduction, thereby suppressing E-cadherin/TGF-beta/p-Smad2/3 signaling axis to elicit ROS-dependent endogenous mitochondrial apoptosis.	ros	213-216	SMAD family member 2	Homo sapiens	180-187
34520770-7	2021	Together, these findings not only provide a new approach for HER2-BC therapy but also increase our understanding of the regulating effect of E-cadherin by HER2 and EphB4 in ROS-mediated apoptosis.	ros	173-176	EPH receptor B4	Homo sapiens	164-169
34790121-6	2021	It is thought that HER2-targeting drugs inhibit HER2/NRG 1 dimer formation, causing an increase in ROS in the mitochondria of cardiomyocytes and inhibiting the PI3K/Akt and Ras/MAPK pathways, resulting in cell apoptosis.	ros	99-102	neuregulin 1	Homo sapiens	53-58
34311033-7	2021	Furthermore, we confirmed the role of TRPC3 and the ROCE-AKT/GSK3beta-CNB2/NFATc2 signaling cascade in regulating cell cycle checkpoint, apoptosis cascade, and intracellular ROS production in GC.	ros	174-177	transient receptor potential cation channel subfamily C member 3	Homo sapiens	38-43
34311033-7	2021	Furthermore, we confirmed the role of TRPC3 and the ROCE-AKT/GSK3beta-CNB2/NFATc2 signaling cascade in regulating cell cycle checkpoint, apoptosis cascade, and intracellular ROS production in GC.	ros	174-177	glycogen synthase kinase 3 alpha	Homo sapiens	61-69
34831092-3	2021	Based upon data demonstrating reduced CTTN mRNA levels in the lungs of smokers compared to non-smokers, we hypothesized a functional role for CTTN in CS-induced mitochondrial ROS generation and apoptosis in lung EC.	ros	175-178	citrate synthase	Homo sapiens	150-152
34831092-5	2021	Exposure to CS significantly increased EC mitochondrial ROS generation and EC apoptosis.	ros	56-59	citrate synthase	Homo sapiens	12-14
34755672-9	2021	Chrysin treatment significantly reduced the generation of endogenous ROS, and treatment with N-Acetyl-L-cysteine to eliminate intracellular ROS obviously reduced the expressions of iNOS and COX-2 (P < 0.05) and blocked the AKT/mTOR pathway (P < 0.05).	ros	140-143	cytochrome c oxidase II, mitochondrial	Mus musculus	190-195
34720999-6	2021	G2385R-LRRK2 increased mitochondrial ROS, activates caspase-3/7, and increased PARP cleavage, resulting in neurotoxicity.	ros	37-40	leucine-rich repeat kinase 2	Mus musculus	7-12
34720999-7	2021	Treatment with curcumin (an antioxidant) significantly protected against G2385R-LRRK2-induced neurodegeneration by reducing mitochondrial ROS, caspase-3/7 activation, and PARP cleavage.	ros	138-141	leucine-rich repeat kinase 2	Mus musculus	80-85
34720999-8	2021	We also found that the cellular environmental stressor, H2O2 significantly promotes both WT-LRRK2- and G2385R-LRRK2-induced neurotoxicity by increasing mitochondrial ROS, caspase-3/7 activation, and PARP cleavage, while curcumin attenuated this combined neurotoxicity.	ros	166-169	leucine-rich repeat kinase 2	Mus musculus	92-97
34720999-8	2021	We also found that the cellular environmental stressor, H2O2 significantly promotes both WT-LRRK2- and G2385R-LRRK2-induced neurotoxicity by increasing mitochondrial ROS, caspase-3/7 activation, and PARP cleavage, while curcumin attenuated this combined neurotoxicity.	ros	166-169	leucine-rich repeat kinase 2	Mus musculus	110-115
34703267-3	2021	APE1/Ref-1 suppresses atherosclerosis via multiple mechanisms, including reducing the IL-6-, TNF-alpha-, and IL-1beta-mediated proinflammatory responses, suppressing ROS-mediated oxidant activity and Bax/Bcl-2-mediated vascular calcification and apoptosis, and reducing LOX-1-mediated cholesterol uptake.	ros	166-169	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	0-4
34703267-3	2021	APE1/Ref-1 suppresses atherosclerosis via multiple mechanisms, including reducing the IL-6-, TNF-alpha-, and IL-1beta-mediated proinflammatory responses, suppressing ROS-mediated oxidant activity and Bax/Bcl-2-mediated vascular calcification and apoptosis, and reducing LOX-1-mediated cholesterol uptake.	ros	166-169	apurinic/apyrimidinic endodeoxyribonuclease 1	Homo sapiens	5-10
34217821-3	2021	This study was designed to decipher whether the protein bound uremic toxin p-cresyl-sulfate (p-CS) could contribute to ROS production in WAT and promote oxidative stress.	ros	119-122	citrate synthase	Homo sapiens	95-97
34217821-8	2021	Pre-treatment of cells with probenecid, apocynin or antioxidants prevented the p-CS induced ROS production and oxidative insults.	ros	92-95	citrate synthase	Homo sapiens	81-83
34246945-0	2021	H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway.	ros	62-65	forkhead box O1	Gallus gallus	85-90
34246945-6	2021	Proteomics analysis was used to reveal the toxicology of thymus injury in broilers, the FOXO signaling pathway was determined to be significantly enriched, ROS bursts and JNK/MST1/FOXO1 pathway activation induced by H2S exposure were detected, and ROS played an important switch role in the JNK/MST1/FOXO1 pathway.	ros	248-251	forkhead box O1	Gallus gallus	300-305
34314760-0	2021	Ghrelin ameliorates cardiac fibrosis after myocardial infarction by regulating the Nrf2/NADPH/ROS pathway.	ros	94-97	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
34314760-1	2021	To evaluate the role of ghrelin in cardiac fibrosis after myocardial infarction (MI) and to investigate the underlying mechanisms of ghrelin-regulated Nrf2/NADPH/ROS pathway-mediated cardioprotection, the profile of Nrf2, fibrosis markers, and oxidative stress markers were characterized in a rat model of MI and Angiotensin II (Ang II)-stimulated cardiac fibroblasts (CFs).	ros	162-165	ghrelin and obestatin prepropeptide	Rattus norvegicus	133-140
34314760-10	2021	In conclusion, ghrelin ameliorates post-MI and Ang II-induced cardiac fibrosis by activating Nrf2, which in turn inhibits the NADPH/ROS pathway.	ros	132-135	ghrelin and obestatin prepropeptide	Rattus norvegicus	15-22
34534913-6	2021	RGS6 is both induced by ROS and increases ROS generation acting as a key amplification node to exacerbate oxidative stress.	ros	24-27	regulator of G-protein signaling 6	Mus musculus	0-4
34534913-6	2021	RGS6 is both induced by ROS and increases ROS generation acting as a key amplification node to exacerbate oxidative stress.	ros	42-45	regulator of G-protein signaling 6	Mus musculus	0-4
34584017-9	2021	On the one hand, the up-regulation of GPR43 gene reduced ROS mitochondrial damage to inhibit inflammatory reactions via the inactivation of NLRP3 Inflammasome by PPARgamma/ Nox1/EBP50/ p47phox signal channel.	ros	57-60	peroxisome proliferator activated receptor gamma	Mus musculus	162-171
34584017-9	2021	On the one hand, the up-regulation of GPR43 gene reduced ROS mitochondrial damage to inhibit inflammatory reactions via the inactivation of NLRP3 Inflammasome by PPARgamma/ Nox1/EBP50/ p47phox signal channel.	ros	57-60	NADPH oxidase 1	Mus musculus	173-177
34584017-10	2021	On the other hand, the down-regulation of GPR43 promoted inflammatory reactions in vitro model through the acceleration of ROS-dependently mitochondrial damage by PPARgamma/ Nox1/EBP50/ p47phox/ NLRP3 signal channel.	ros	123-126	peroxisome proliferator activated receptor gamma	Mus musculus	163-172
34581906-14	2021	Furthermore, ZIP7 cKO reduced mitochondrial ROS generation and myocardial infarction via a PINK1-dependet manner, whereas overexpression of ZIP7 exacerbated myocardial infarction.	ros	44-47	solute carrier family 39 member 7	Homo sapiens	13-17
34646383-10	2021	The deletion of PDK1 in Treg cells destroyed the iron ion balance through regulating MEK-ERK signaling and CD71 expression, resulting in excessive production of intracellular ROS, which did not depend on the down-regulation of mTORC1 signaling.	ros	175-178	midkine	Mus musculus	85-88
34342641-4	2021	Glutathionylation of ASC inhibits ASC oligomerization and thus represses activation of NLRP3 inflammasome in macrophages, unless GSTO1 binds ASC and deglutathionylates ASC at ER, under control of mitochondrial ROS and triacylglyceride synthesis.	ros	210-213	glutathione S-transferase omega 1	Mus musculus	129-134
34342641-5	2021	In macrophages expressing ASCC171A, a mutant ASC without glutathionylation site, activation of NLRP3 inflammasome is GSTO1 independent, ROS independent, and signal 2 less dependent.	ros	136-139	steroid sulfatase	Mus musculus	45-48
34153664-7	2021	Inhibition of HMGB1 decreased Nrf2 expression and ROS release, improved MMP level and reduced NLRP3 inflammasome activation.	ros	50-53	high mobility group box 1	Homo sapiens	14-19
34513812-15	2021	Overexpression of NOX4 abolished the effects in which HucMSC-EVs inhibited DOX-induced ROS, oxidative stress, and apoptosis increases.	ros	87-90	NADPH oxidase 4	Homo sapiens	18-22
34175438-0	2021	Transduced Tat-PRAS40 prevents dopaminergic neuronal cell death through ROS inhibition and interaction with 14-3-3sigma protein.	ros	72-75	tyrosine aminotransferase	Homo sapiens	11-14
34901534-6	2022	When HL-60 cells were treated by Au@Ce NPs, the removal of endogenous ROS signal significantly arrested cell cycle at G1 phase and suppressed the cell proliferation by blocking the mitogen-activated protein kinases (MAPKs) signaling and the Akt/Cyclin D1 cell cycle signaling.	ros	70-73	cyclin D1	Homo sapiens	245-254
34382418-10	2021	CONCLUSION: Our results indicate that NDP52 promotes autophagic flux and clears damaged mitochondria to diminish ROS and cell death in a TBK1/RAB7-dependent manner and thus limits MI induced injury.	ros	113-116	calcium binding and coiled-coil domain 2	Homo sapiens	38-43
34422676-8	2021	T. cruzi cells overexpressing pol beta are more resistant to ROS and are also more efficient to repair 8oxoG compared to control cells.	ros	61-64	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	30-38
34422676-10	2021	ROS treatment of cells induces the overexpression of pol beta, indicating that plays a role in kDNA repair.	ros	0-3	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	53-61
34394825-5	2021	Furthermore, we confirmed that FAM134B-mediated ER-phagy was activated under AGEs stimulation via ROS pathway.	ros	98-101	reticulophagy regulator 1	Homo sapiens	31-38
34394825-6	2021	Importantly, it was also found that FAM134B overexpression could efficiently relieve intracellular ROS accumulation, apoptosis, and senescence upon AGEs treatment; conversely, FAM134B knockdown markedly resulted in opposite effects.	ros	99-102	reticulophagy regulator 1	Homo sapiens	36-43
34394825-7	2021	In conclusion, our data demonstrate that FAM134B-mediated ER-phagy plays a vital role in AGEs-induced apoptosis and senescence through modulating cellular ROS accumulation, and targeting FAM134B-mediated ER-phagy could be a promising therapeutic strategy for IDD treatment.	ros	155-158	reticulophagy regulator 1	Homo sapiens	41-48
34267821-9	2021	The present study suggested that PEDF may exert antitumor effects in AGE-exposed breast cancer cells by suppressing NADPH oxidase-induced ROS generation and VEGF and MMP-9 expression via interaction with LR.	ros	138-141	serpin family F member 1	Homo sapiens	33-37
34359683-6	2021	We found that bexarotene (Bex) treatment resulted in a dramatic decline in oxidative stress and Tert-butylhydroquinone (tBHQ)-induced levels of BRF2 and consequently led to a decrease in the cellular proliferation of cancer cells which may in part be due to the drug pretreatment-induced reduction of ROS generated by the oxidizing agent.	ros	301-304	BRF2 RNA polymerase III transcription initiation factor subunit	Homo sapiens	144-148
34294686-5	2021	Moreover, ROS generation elicited by afatinib was responsible for the induction of the REDD1-TSC1-mTORC1 axis.	ros	10-13	CREB regulated transcription coactivator 1	Mus musculus	98-104
34238980-1	2021	Cytosolic ROS, generated by NADPH oxidase 2 (Nox2) in diabetes, damage retinal mitochondria, which leads to the development of retinopathy.	ros	10-13	cytochrome b-245, beta polypeptide	Mus musculus	28-43
34238980-1	2021	Cytosolic ROS, generated by NADPH oxidase 2 (Nox2) in diabetes, damage retinal mitochondria, which leads to the development of retinopathy.	ros	10-13	cytochrome b-245, beta polypeptide	Mus musculus	45-49
34233649-14	2021	The mechanism governing Cox7a2-mediated apoptosis of HIV-infected macrophages revealed that targeting respiratory chain complex II and IV genes also selectively induced apoptosis of HIV-infected macrophages possibly through enhanced ROS production.	ros	233-236	cytochrome c oxidase subunit 7A2	Homo sapiens	24-30
34128315-0	2021	C/EBP homologous protein deficiency enhances hematopoietic stem cell function via reducing ATF3/ROS-induced cell apoptosis.	ros	96-99	activating transcription factor 3	Mus musculus	91-95
34128315-8	2021	Mechanistically, CHOP deletion causes reduced ATF3 expression and further leads to decreased protein aggregation and ROS.	ros	117-120	activating transcription factor 3	Mus musculus	46-50
34120142-1	2021	SOS1 ablation causes specific defective phenotypes in MEFs including increased levels of intracellular ROS.	ros	103-106	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	0-4
34120142-2	2021	We showed that the mitochondria-targeted antioxidant MitoTEMPO restores normal endogenous ROS levels, suggesting predominant involvement of mitochondria in generation of this defective SOS1-dependent phenotype.	ros	90-93	SOS Ras/Rac guanine nucleotide exchange factor 1	Homo sapiens	185-189
34163028-7	2021	Our results further demonstrate that MUC1-C integrates activation of PBRM1 with the regulation of antioxidant genes, ROS levels, pluripotency factor expression and the cancer stem cell (CSC) state.	ros	117-120	mucin 1, cell surface associated	Homo sapiens	37-41
34187574-3	2021	Here, we aim that Jdp2 plays a critical role of cerebellar development which is affected by the ROS regulation and redox control.	ros	96-99	Jun dimerization protein 2	Mus musculus	18-22
34176927-5	2021	In HeLa and 4T1 cells, LDHA or LDHB knockout or LDH inhibitor FX11 significantly decreased ROS induction by modulators of the mitochondrial electron transfer chain (antimycin, oligomycin, rotenone), hypoxia, and pharmacological ROS inducers piperlogumine (PL) and phenethyl isothiocyanate (PEITC).	ros	91-94	lactate dehydrogenase A	Mus musculus	23-27
34148367-3	2022	Excess ROS, a signature of primed neutrophils, can intracellularly induce neutrophils to undergo NETosis, flooding surrounding tissues with ROS and damage-associated molecular patterns (DAMPs) such as S100 calcium binding proteins (S100A8/A9).	ros	7-10	S100 calcium binding protein A8	Homo sapiens	232-241
34166222-12	2021	In conclusion: Nesfatin-1 alleviated the impairment of male reproductive functions induced by NT via enhancement of autophagy pathways, suppression of pyroptosis, apoptosis, mitochondrial dysfunction and ROS production.	ros	204-207	nucleobindin 2	Rattus norvegicus	15-25
34234852-6	2021	In this study, V-ATPase inhibition sensitized human cervical cancer, breast cancer, and murine melanoma cells to anoikis via increased ROS production, accumulation of misfolded protein, and impaired pulmonary metastasis in vivo.	ros	135-138	ATPase, H+ transporting, lysosomal V0 subunit D2	Mus musculus	15-23
34177609-12	2021	Taken together, our study demonstrated that nicotine treatment may lead to an increase in Drp1-mediated mitochondrial fission by blocking mitophagic flux by weakening the enzyme activity of CTSL and activating the ROS/p38/JNK signaling pathway.	ros	214-217	mitogen activated protein kinase 14	Rattus norvegicus	218-221
34350235-12	2021	Administration of ghrelin attenuated the mitochondria damage via reducing ROS generation, decreasing the concentration of calcium ion and ceremide, and promoting ATP production.	ros	74-77	ghrelin and obestatin prepropeptide	Rattus norvegicus	18-25
34079902-6	2021	Downregulation of hTRPV2 reduces sensitivity to PL and decreases ROS production.	ros	65-68	transient receptor potential cation channel subfamily V member 2	Homo sapiens	18-24
34067282-10	2021	The results showed Rap1a overlaps the AGE/RAGE cascade to increase the myofibroblast population and generation of ROS production.	ros	114-117	RAS-related protein 1a	Mus musculus	19-24
2491807-0	1989	Inhibitory effects of tumor necrosis factor-alpha and interferon-gamma on deoxyribonucleic acid and collagen synthesis by rat osteosarcoma cells (ROS 17/2.8).	ros	146-149	interferon gamma	Rattus norvegicus	54-70
2821688-3	1987	Production of the transforming proteins p 150 gag-fps and p68 gag-ros of UR1 and UR2, respectively, was similar to that of transformed chick embryo fibroblasts, as judged from in vitro kinase activity assays.	ros	66-69	annexin A6	Gallus gallus	58-61
32838607-5	2021	Knockdown of miR-1225-5p elevates ROS level via regulating Keap1/Nrf2 pathway.	ros	34-37	microRNA 1225	Homo sapiens	13-21
33990669-12	2021	By gene silencing of HIF-1alpha and miR-210 the expression of PDHA1 was upregulated while that of MITF-M was downregulated, yielding acceleration of mitochondrial respiratory activity and thus elimination of ROS.	ros	208-211	pyruvate dehydrogenase E1 subunit alpha 1	Homo sapiens	62-67
33980809-8	2021	It was found that beta-catenin regulated apatinib-induced production of ROS.	ros	72-75	catenin beta 1	Homo sapiens	18-30
33980809-9	2021	Inhibition or promotion of ROS production with N-acetyl-L-cysteine or H2O2 not only upregulated or downregulated beta-catenin expression, but also prevented or promoted DNA damage, rescued or impeded sphere formation, respectively.	ros	27-30	catenin beta 1	Homo sapiens	113-125
33942214-6	2021	TP53 (also known as p53) was verified as a target of miR-122-5p by using dual luciferase reporter assay, and restoration of TP53 attenuated the effects of miR-122-5p on ferroptotic marker proteins expression, iron ion concentration and lipid ROS levels, as well as solute carrier family seven member 11 (SLC7A11) mRNA expression.	ros	242-245	transformation related protein 53	Mus musculus	0-4
33942214-6	2021	TP53 (also known as p53) was verified as a target of miR-122-5p by using dual luciferase reporter assay, and restoration of TP53 attenuated the effects of miR-122-5p on ferroptotic marker proteins expression, iron ion concentration and lipid ROS levels, as well as solute carrier family seven member 11 (SLC7A11) mRNA expression.	ros	242-245	transformation related protein 53	Mus musculus	20-23
33942214-6	2021	TP53 (also known as p53) was verified as a target of miR-122-5p by using dual luciferase reporter assay, and restoration of TP53 attenuated the effects of miR-122-5p on ferroptotic marker proteins expression, iron ion concentration and lipid ROS levels, as well as solute carrier family seven member 11 (SLC7A11) mRNA expression.	ros	242-245	transformation related protein 53	Mus musculus	124-128
33824482-0	2021	Correction: IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.	ros	85-88	IQ motif containing GTPase activating protein 1	Homo sapiens	12-18
33616799-6	2021	Here we focus on the potential of NAC genes in the regulation of abiotic stress tolerance, secondary cell wall synthesis, lateral root development, yield potential, seed size and biomass, ROS signaling, leaf senescence, and programmed cell death.	ros	188-191	synuclein alpha	Homo sapiens	34-37
33914705-9	2021	Secondly, via an iron dependent, lipid peroxidation-independent pathway, HIF-2alpha activation potentiated ROS, via irreversible cysteine oxidation and enhanced cell death.	ros	107-110	endothelial PAS domain protein 1	Mus musculus	73-83
33914705-10	2021	Inhibition or knockdown of HIF-2alpha decreased ROS and resistance to oxidative cell death in vitro and in vivo.	ros	48-51	endothelial PAS domain protein 1	Mus musculus	27-37
33932464-0	2021	Blocking endothelial TRPV4-Nox2 interaction helps reduce ROS production and inflammation, and improves vascular function in obese mice.	ros	57-60	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	21-26
33904141-10	2021	Anti-IL-23 reduced ROS molecules of STAT downstream in the serum and brain.	ros	19-22	interleukin 23 subunit alpha	Homo sapiens	5-10
33967677-7	2021	Finally, our proteomic evaluation suggested an anti-inflammatory mechanism of Ang-(1-7) toward the ROS modulators Uchl1 and Prdx1.	ros	99-102	peroxiredoxin 1	Rattus norvegicus	124-129
33967776-0	2021	Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos.	ros	119-122	nfe2 like bZIP transcription factor 2a	Danio rerio	15-19
33967776-0	2021	Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos.	ros	119-122	mitogen-activated protein kinase 8b	Danio rerio	25-28
33967776-12	2021	Taken together, all these parameters collectively provide the first evidence of AC-induced developmental toxicity in zebrafish embryo/larvae through ROS-medicated mitochondrial apoptosis involving Nrf2/HO-1 and JNK/Erk pathways.	ros	149-152	nfe2 like bZIP transcription factor 2a	Danio rerio	197-201
33967776-12	2021	Taken together, all these parameters collectively provide the first evidence of AC-induced developmental toxicity in zebrafish embryo/larvae through ROS-medicated mitochondrial apoptosis involving Nrf2/HO-1 and JNK/Erk pathways.	ros	149-152	mitogen-activated protein kinase 8b	Danio rerio	211-214
34170261-10	2021	Simultaneous or separate administration of artemisinin and TSP-1-hEDSCs ameliorated this influence by considerably reducing Abeta plaque formation in the hippocampus, reducing glucose, MDA, ROS, and TNF-alpha levels, and increasing TAC levels.	ros	190-193	thrombospondin 1	Rattus norvegicus	59-64
11483159-12	2001	On the other hand, Sod1p could be involved in the control of ROS production; these reactive molecules could signal the induction of genes implicated within cell tolerance to heat and ethanol.	ros	61-64	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	19-24
34269120-3	2021	Here, we showed that knockdown of LEF1 could apparently impair the proliferation, induce apoptosis and promote the ROS production in MM cell lines, suggesting that LEF1 might be involved in maintaining MM cell growth and survival.	ros	115-118	lymphoid enhancer binding factor 1	Homo sapiens	34-38
34269120-3	2021	Here, we showed that knockdown of LEF1 could apparently impair the proliferation, induce apoptosis and promote the ROS production in MM cell lines, suggesting that LEF1 might be involved in maintaining MM cell growth and survival.	ros	115-118	lymphoid enhancer binding factor 1	Homo sapiens	164-168
35617999-15	2022	To conclude, CO released from CORM-2 can prevent the LTA-stimulated HGFs from increasing VCAM-1 and ICAM-1 expression and promoting monocyte adhesion by inhibiting TLR2/MyD88/TRAF6 association and PI3K/Akt/NADPH oxidase/ROS signaling, both converge on the canonical NF-kappaB activation.	ros	220-223	MYD88 innate immune signal transduction adaptor	Homo sapiens	169-174
33919418-0	2021	Arabidopsis CCoAOMT1 Plays a Role in Drought Stress Response via ROS- and ABA-Dependent Manners.	ros	65-68	S-adenosyl-L-methionine-dependent methyltransferases superfamily protein	Arabidopsis thaliana	12-20
33887441-5	2021	In vitro studies indicated that K8 and K24 are nontoxic to nervous tissue cells and they have considerable effects against ROS formation and potential neuroprotective activity.	ros	123-126	keratin 24	Homo sapiens	39-42
11162900-8	2000	hPTHrP (1-139) stimulated cAMP accumulation in ROS 17/2.8 osteoblastic bone cells, whereas hPTHrP (27-139) failed to elicit a response.	ros	47-50	parathyroid hormone like hormone	Homo sapiens	0-6
33863916-3	2021	We show that pharmacological or genetic manipulations that increase mtH2O2 levels lead to increased FLP-1 secretion that is dependent upon ROS dismutation, mitochondrial calcium influx, and cysteine sulfenylation of the calcium-independent PKC family member PKC-1.	ros	139-142	SQPNFLRF-amide	Caenorhabditis elegans	100-105
33863916-4	2021	mtH2O2-induced FLP-1 secretion activates the oxidative stress response transcription factor SKN-1/Nrf2 in distal tissues and protects animals from ROS-mediated toxicity.	ros	147-150	SQPNFLRF-amide	Caenorhabditis elegans	15-20
33863916-4	2021	mtH2O2-induced FLP-1 secretion activates the oxidative stress response transcription factor SKN-1/Nrf2 in distal tissues and protects animals from ROS-mediated toxicity.	ros	147-150	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	92-97
11127200-0	2000	Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor beta1 and bone morphogenetic protein 2 in ROS 17/2.8 osteoblast-like cells.	ros	162-165	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	8-27
33524379-5	2021	Overexpression of RIPK1 facilitated cell apoptosis, necrosis, inflammation response, ROS production and mitochondrial dysfunction in MPP+- treated SH-SY5Y cells, while the RIPK1 inhibitor Nec-1s has an opposite effect.	ros	85-88	receptor interacting serine/threonine kinase 1	Homo sapiens	18-23
33917526-8	2021	Among all types of ROS/RNS-mediated treatments, plasma exposure exerted the most notable increase of activation markers at 24 h such as CD25, CD40, and CD83 known to be crucial for T cell costimulation.	ros	19-22	CD83 molecule	Homo sapiens	152-156
34654876-8	2022	Furthermore, we showed that interrupting TRPV4-Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.	ros	218-221	cytochrome b-245, beta polypeptide	Mus musculus	47-51
34654876-8	2022	Furthermore, we showed that interrupting TRPV4-Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.	ros	218-221	cytochrome b-245, beta polypeptide	Mus musculus	112-116
11127200-0	2000	Role of activator protein 1 transcriptional activity in the regulation of gene expression by transforming growth factor beta1 and bone morphogenetic protein 2 in ROS 17/2.8 osteoblast-like cells.	ros	162-165	bone morphogenetic protein 2	Rattus norvegicus	130-158
34654876-8	2022	Furthermore, we showed that interrupting TRPV4-Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.	ros	218-221	cytochrome b-245, beta polypeptide	Mus musculus	127-131
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-42
33918312-11	2021	These effects were all suppressed by pretreatment with the ROS scavenger NAC.	ros	59-62	synuclein alpha	Homo sapiens	73-76
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	109-113
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	bone morphogenetic protein 2	Rattus norvegicus	160-165
10962570-5	2000	Although the caspase 8 specific inhibitor z-IETD.fmk did not affect translocation of BAX to the mitochondrial membrane and cytochrome C release it almost completely blocked cleavage of the prototype caspase substrate PARP and DNA fragmentation while enforcing mitochondrial depolarization and production of reactive oxygene species (ROS).	ros	333-336	collagen type XI alpha 2 chain	Homo sapiens	217-221
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	212-215	serine/threonine kinase 11	Homo sapiens	309-313
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	302-305	serine/threonine kinase 11	Homo sapiens	309-313
33789208-5	2021	Low mitochondrial Sirt3 (mtSirt3) in males versus females is associated with development of kidney tubular epithelium vacuoles, increased mitochondrial ROS and susceptibility to IRI.	ros	152-155	sirtuin 3	Mus musculus	18-23
33756120-6	2021	The resulting ROS signals simultaneously convey HAK5 K+ uptake-transporter induction and accelerated Casparian strip maturation.	ros	14-17	high affinity K+ transporter 5	Arabidopsis thaliana	48-52
35447293-0	2022	DEHP induces ferroptosis in testes via p38alpha-lipid ROS circulation and destroys the BTB integrity.	ros	54-57	mitogen-activated protein kinase 14	Mus musculus	39-47
35617030-11	2022	These were prevented in Nox4-/- and by pharmacological inhibition of Nox4 or Rock.Commonly used chemotherapeutic agents, and in particular, docetaxel, alter vascular function by promoting inhibitory phosphorylation of eNOS and enhancing ROS production by NADPH oxidases.	ros	237-240	NADPH oxidase 4	Mus musculus	69-73
35625931-5	2022	Compared to WT PMNs, Pkm2-deficient (Pkm2-/-) PMNs displayed significantly less capacity for fMLP- or PMA-induced degranulation of secondary and tertiary granules, ROS production, and transfilter migration.	ros	164-167	pyruvate kinase, muscle	Mus musculus	21-25
35625931-5	2022	Compared to WT PMNs, Pkm2-deficient (Pkm2-/-) PMNs displayed significantly less capacity for fMLP- or PMA-induced degranulation of secondary and tertiary granules, ROS production, and transfilter migration.	ros	164-167	pyruvate kinase, muscle	Mus musculus	37-41
35609655-6	2022	Oxidative stress assay showed that ROS and apoptosis were highest in the fish exposed to beta-2 and delta-2 isomers of HCH in comparison to the untreated one.	ros	35-38	zgc:103599	Danio rerio	89-95
35589816-6	2022	HL-003 reduced oxidative stress in the salivary gland by regulating the expression of ROS-related proteins NOX4, SOD2, and 8-OHdG.	ros	86-89	NADPH oxidase 4	Mus musculus	107-111
35585372-2	2022	PKCdelta is involved in the intracellular production of reactive oxidative species (ROS).	ros	84-87	protein kinase C delta	Homo sapiens	0-8
35570330-2	2022	In this study, we show that the secretion of ORF8 is dependent on its N-terminal signal peptide sequence and can be inhibited by ROS scavenger and ER-Golgi transportation inhibitor in cultured cells.	ros	129-132	ORF8 protein	Severe acute respiratory syndrome coronavirus 2	45-49
35562675-8	2022	The PTGS2/NF-kb pathway, TGF-beta/Smad signaling pathway and AGE-RAGE signaling pathway in diabetic complications may be the major signaling pathways under conditions of ROS-induced damage in TM cells.	ros	170-173	transforming growth factor alpha	Homo sapiens	25-33
35521658-5	2022	Removal of domains is necessary for ATF3/Tip60 binding compromises RGS7-dependent ROS generation and cell death.	ros	82-85	regulator of G protein signaling 7	Homo sapiens	67-71
35571237-0	2022	ROS-Responsive miR-150-5p Downregulation Contributes to Cigarette Smoke-Induced COPD via Targeting IRE1alpha.	ros	0-3	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	99-108
35247821-8	2022	Furthermore, blocking ASIC1a led to a robust mitochondrial ROS production induced by L-lactate.	ros	59-62	acid-sensing (proton-gated) ion channel 1	Mus musculus	22-28
35510037-2	2022	Regulator of G protein signaling 6 (RGS6) is involved in controlling ROS generation and inflammatory response under different contexts.	ros	69-72	regulator of G-protein signaling 6	Mus musculus	0-34
35510037-2	2022	Regulator of G protein signaling 6 (RGS6) is involved in controlling ROS generation and inflammatory response under different contexts.	ros	69-72	regulator of G-protein signaling 6	Mus musculus	36-40
35541901-13	2022	Conclusion: GRP75-overexpression confers CP-resistance by distinctively managing MAM-facilitated Ca2+ fluxes and the pro-survival ROS signal, whereas GRP75-deficiency induces cell death via bioenergetic crisis and apoptotic ROS accumulation in OC cells.	ros	224-227	sarcoglycan gamma	Homo sapiens	81-84
35396551-8	2022	Finally, GLX351322, an inhibitor targeting NOX4, was used to inhibit NOX4-derived ROS in vitro and detect its effect on drug resistance of tumor cells in vivo.	ros	82-85	NADPH oxidase 4	Homo sapiens	43-47
35396551-8	2022	Finally, GLX351322, an inhibitor targeting NOX4, was used to inhibit NOX4-derived ROS in vitro and detect its effect on drug resistance of tumor cells in vivo.	ros	82-85	NADPH oxidase 4	Homo sapiens	69-73
35396551-11	2022	When the starved cells or LRBCs are treated with chemotherapeutic drugs or Lenvatinib, NOX4 knockdown inhibits cell viability and aggravates cell apoptosis depending on NOX4-derived ROS production.	ros	182-185	NADPH oxidase 4	Homo sapiens	87-91
35396551-11	2022	When the starved cells or LRBCs are treated with chemotherapeutic drugs or Lenvatinib, NOX4 knockdown inhibits cell viability and aggravates cell apoptosis depending on NOX4-derived ROS production.	ros	182-185	NADPH oxidase 4	Homo sapiens	169-173
35396551-14	2022	GLX351322, a NOX4-derived ROS inhibitor, has an inhibitory effect on cell growth in vitro and the growth of BCPAP-derived even LRBCs-derived xenografts in vivo.	ros	26-29	NADPH oxidase 4	Homo sapiens	13-17
35396551-15	2022	These findings highlight NOX4 and NOX4-derived ROS as a potential therapeutic target in resistance to PTC.	ros	47-50	NADPH oxidase 4	Homo sapiens	34-38
35081328-7	2022	By interfering with DUOX2/NADPH oxidase-dependent ROS production, Roscovitine reduces the number of neutrophils at infection sites, and consequently compromises granuloma formation and maintenance, favouring extracellular multiplication of M. abscessus and more severe infection.	ros	50-53	dual oxidase 2	Danio rerio	20-25
35351997-7	2022	AG1 increased tumor cell ROS production and the resultant extrinsic and intrinsic death pathways, mitochondrial processes, and unfolded protein response in tumor cells.	ros	25-28	dentin matrix protein 1	Mus musculus	0-3
35254586-4	2022	We found that PRRSV infection caused significant AMPK activation in a time-dependent manner via the ROS-calcium/calmodulin-dependent protein kinase-2 pathway.	ros	100-103	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	49-53
35338333-6	2022	MIOX increased ROS production and decreased the intracellular levels of NADPH and GSH, resulting in enhanced erastin- and RSL3-induced ferroptosis.	ros	15-18	myo-inositol oxygenase	Homo sapiens	0-4
35258392-6	2022	Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.Abbreviations: AMPK: AMP-activated protein kinase; AOX: alternative oxidase; Baf A: bafilomycin A1; CI, respiratory complexes I; DCF-DA: 2",7"-dichlordihydrofluorescein diacetate; DHE: dihydroethidium; DSS: dextran sodium sulfate; DeltaPsimi: mitochondrial inner membrane potential; EdU: 5-ethynyl-2"-deoxyuridine; ETC: electron transport chain; FA: formaldehyde; HUVEC; human umbilical cord endothelial cells; IBD: inflammatory bowel disease; LC3B: microtubule associated protein 1 light chain 3 beta; LPS: lipopolysaccharide; MEFs: mouse embryonic fibroblasts; MTORC1: mechanistic target of rapamycin kinase complex 1; mtDNA: mitochondrial DNA; NAC: N-acetyl cysteine; OXPHOS: oxidative phosphorylation; PCs: proliferating cells; PE: phosphatidylethanolamine; PEITC: phenethyl isothiocyanate; QCs: quiescent cells; ROS: reactive oxygen species; PLA2: phospholipase A2, WB: western blot.	ros	126-129	microtubule associated protein 1 light chain 3 beta	Homo sapiens	687-691
35258392-6	2022	Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.Abbreviations: AMPK: AMP-activated protein kinase; AOX: alternative oxidase; Baf A: bafilomycin A1; CI, respiratory complexes I; DCF-DA: 2",7"-dichlordihydrofluorescein diacetate; DHE: dihydroethidium; DSS: dextran sodium sulfate; DeltaPsimi: mitochondrial inner membrane potential; EdU: 5-ethynyl-2"-deoxyuridine; ETC: electron transport chain; FA: formaldehyde; HUVEC; human umbilical cord endothelial cells; IBD: inflammatory bowel disease; LC3B: microtubule associated protein 1 light chain 3 beta; LPS: lipopolysaccharide; MEFs: mouse embryonic fibroblasts; MTORC1: mechanistic target of rapamycin kinase complex 1; mtDNA: mitochondrial DNA; NAC: N-acetyl cysteine; OXPHOS: oxidative phosphorylation; PCs: proliferating cells; PE: phosphatidylethanolamine; PEITC: phenethyl isothiocyanate; QCs: quiescent cells; ROS: reactive oxygen species; PLA2: phospholipase A2, WB: western blot.	ros	126-129	microtubule associated protein 1 light chain 3 beta	Homo sapiens	693-744
35326115-9	2022	Expression levels of ROS generators (NOX-1 and NOX-2) and antioxidant proteins (GR, HO-1, NQO-1) were upregulated in brain tissue with loss of neuronal Pnn, echoing an increase in oxidized proteins in cortical and hippocampal neurons.	ros	21-24	NADPH oxidase 1	Mus musculus	37-42
35326115-9	2022	Expression levels of ROS generators (NOX-1 and NOX-2) and antioxidant proteins (GR, HO-1, NQO-1) were upregulated in brain tissue with loss of neuronal Pnn, echoing an increase in oxidized proteins in cortical and hippocampal neurons.	ros	21-24	cytochrome b-245, beta polypeptide	Mus musculus	47-52
35326115-9	2022	Expression levels of ROS generators (NOX-1 and NOX-2) and antioxidant proteins (GR, HO-1, NQO-1) were upregulated in brain tissue with loss of neuronal Pnn, echoing an increase in oxidized proteins in cortical and hippocampal neurons.	ros	21-24	pinin	Mus musculus	152-155
35196257-7	2022	The decrease in this antioxidant enzyme correlated with increased production of mitochondrial ROS in MDPL cells, compared to WT.	ros	94-97	DNA polymerase delta 1, catalytic subunit	Homo sapiens	101-105
35150326-0	2022	Blue light induces ROS mediated apoptosis and degradation of AML1-ETO oncoprotein in Kasumi-1 cells.	ros	19-22	RUNX1 partner transcriptional co-repressor 1	Homo sapiens	66-69
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	ros	318-321	glutathione-disulfide reductase	Homo sapiens	150-171
35198762-10	2022	After stimulation with resiquimod, GW7647-an agonist for PPARalpha (an inducer of NADHP oxidase)-and siRNA for UCP2 (a negative regulator of mitochondrial ROS generation) enhanced TNFAIP3 and reduced IL-23.	ros	155-158	TNF alpha induced protein 3	Homo sapiens	180-187
35198762-14	2022	TNFAIP3 and Sp1 levels are reciprocally regulated through ROS generation.	ros	58-61	TNF alpha induced protein 3	Homo sapiens	0-7
35185572-6	2022	The ROS content in the cells of co-treated with isoorientin and oleic acid was significantly reduced compared to the oleic acid group, and the expression of gammaH2AX, HO-1, PPARgamma, SREBP-1c, FAS, and the nuclear translocation of NF-kappaB p65 were also significantly inhibited.	ros	4-7	sterol regulatory element binding transcription factor 1	Rattus norvegicus	185-193
35154560-6	2022	Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is most closely related to the formation of ROS during ischemic stroke.	ros	105-108	NADPH oxidase 4	Homo sapiens	0-53
35154560-6	2022	Nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) is most closely related to the formation of ROS during ischemic stroke.	ros	105-108	NADPH oxidase 4	Homo sapiens	55-59
35184409-0	2022	Myocardin-related transcription factor A drives ROS-fueled expansion of hepatic stellate cells by regulating p38-MAPK signalling.	ros	48-51	myocardin related transcription factor A	Homo sapiens	0-40
35039634-5	2022	Mechanistically, CAMK2G directly senses ROS, both basal and cisplatin-induced, to control the phosphorylation of ITPKB at serine 174, which directly regulates ITPKB activity to modulate cisplatin-induced ROS stress.	ros	204-207	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	17-23
35039634-8	2022	This study reveals a key kinase network consisting of CAMK2G and ITPKB for ROS sense and scavenging in ovarian cancer cells to maintain redox homeostasis, offering a potential strategy for cisplatin resistance treatment.	ros	75-78	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	54-60
35035671-12	2022	NOX4 siRNA was used to futher verify the effect of FA on NOX4/ROS pathway.	ros	62-65	NADPH oxidase 4	Homo sapiens	0-4
35035671-12	2022	NOX4 siRNA was used to futher verify the effect of FA on NOX4/ROS pathway.	ros	62-65	NADPH oxidase 4	Homo sapiens	57-61
35035671-14	2022	Mechanically, FA down-regulated NOX4/ROS signaling pathway to improve oxidation imbalances, and subsequently inhibited PI3K/Akt pathway to suppress proliferation.	ros	37-40	NADPH oxidase 4	Homo sapiens	32-36
35035671-16	2022	Furthermore, the effects of FA on TGF-beta1-induced increased ROS levels and alpha-SMA and COLI expression were weaken by silencing NOX4.	ros	62-65	NADPH oxidase 4	Homo sapiens	132-136
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	ros	154-157	interleukin 1 alpha	Homo sapiens	35-43
33729569-10	2021	RESULTS: High glucose could induce IL-1beta-driven inflammatory responses in HGFs via the activation of NLRP3 inflammasome regulated by TLR2/TLR4 coupled ROS in NF-kappaB-dependent manner.	ros	154-157	toll like receptor 4	Homo sapiens	141-145
33246325-7	2021	Finally, EZH2 silencing exacerbated oxidative stress by increasing ROS levels and disrupting the distribution of active mitochondria in porcine oocytes.	ros	67-70	enhancer of zeste 2 polycomb repressive complex 2 subunit	Sus scrofa	9-13
33690671-13	2021	Furthermore, young L-Lep demonstrated greater ability to neutralize ROS compared to elderly L-Lep patients, who presented lower gene expression of antioxidant enzymes, mainly glutathione peroxidase.	ros	68-71	leptin	Homo sapiens	21-24
33676948-7	2021	In human keratinocytes, MTH1 inhibition prevented the upregulation of IL-17 downstream genes, which was independent of ROS-induced apoptosis.	ros	119-122	nudix hydrolase 1	Homo sapiens	24-28
33707964-10	2021	Furthermore, N-acetylcysteine (NAC), an ROS scavenger, inhibited the LPS/ATP-stimulated activation of NLRP3 inflammasome mediated inflammation and pyroptosis.	ros	40-43	NLR family, pyrin domain containing 3	Mus musculus	102-107
33658472-10	2021	In addition, miR-145-5p overexpression increased SOD activity and reduced ROS and MDA content under OGD/R stress.	ros	74-77	microRNA 145	Rattus norvegicus	13-20
33676890-0	2021	Citrus-derived DHCP inhibits mitochondrial complex II to enhance TRAIL sensitivity via ROS-induced DR5 upregulation.	ros	87-90	TNF receptor superfamily member 10b	Homo sapiens	99-102
33676890-7	2021	ROS significantly increase the expression of TRAIL death receptor 5 (DR5) via the p53 and C/EBP homologous protein pathways.	ros	0-3	TNF receptor superfamily member 10b	Homo sapiens	69-72
33754072-0	2021	Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation.	ros	94-97	vanin 1	Rattus norvegicus	80-84
33754072-6	2021	Results: We found that the upregulation of S100A9 induces cell injury and inflammatory response via NLRP3 activation by targeting VNN1-mediated ROS release; and loss of S100A9 decreases AP injury in vitro and in vivo.	ros	144-147	vanin 1	Rattus norvegicus	130-134
33421718-13	2021	In addition, BaP increased mitochondrial ROS production, and Mito-TEMP, a mitochondrial ROS inhibitor, inhibited BaP-induced MUC5AC expression and ERK activation.	ros	88-91	bap	None	113-116
33421718-18	2021	Furthermore, resveratrol treatment inhibited the BaP-induced MUC5AC overexpression, AhR translocation, mitochondrial ROS production and ERK pathway activation.	ros	117-120	bap	None	49-52
33421718-19	2021	CONCLUSION: Here, we highlighted the crucial role of AhR/mitochondrial ROS/ERK pathway activation in BaP-induced MUC5AC overexpression and identified resveratrol as a promising drug to reduce BaP-induced MUC5AC overexpression.	ros	71-74	bap	None	101-104
33460768-7	2021	NPGPx is activated by ROS generated from TCR stimulation, and modulates ZAP70 activity through redox switching to reduce ZAP70 recruitment to TCR/CD3 complex in membrane lipid raft, therefore subduing TCR responses.	ros	22-25	T cell receptor alpha variable 6-3	Mus musculus	41-44
33412215-6	2021	KEY FINDINGS: Metformin reduced HG-induced endothelial ROS by upregulating OGG1.	ros	55-58	8-oxoguanine DNA glycosylase	Homo sapiens	75-79
33485149-0	2021	Loss of function of the chloroplast membrane K+/H+ antiporters AtKEA1 and AtKEA2 alters the ROS and NO metabolism but promotes drought stress resilience.	ros	92-95	K+ efflux antiporter 1	Arabidopsis thaliana	63-69
33485149-5	2021	The loss of function of AtKEA1 and AtKEA2 did not cause oxidative stress but it provoked an alteration of the ROS homeostasis affecting some ROS-generating enzymes.	ros	110-113	K+ efflux antiporter 1	Arabidopsis thaliana	24-30
33485149-5	2021	The loss of function of AtKEA1 and AtKEA2 did not cause oxidative stress but it provoked an alteration of the ROS homeostasis affecting some ROS-generating enzymes.	ros	141-144	K+ efflux antiporter 1	Arabidopsis thaliana	24-30
33485149-10	2021	Data suggest that the chloroplast osmotic balance and integrity maintained by AtKEA1 and AtKEA2 are necessary to keep the balance of ROS/RNS metabolism.	ros	133-136	K+ efflux antiporter 1	Arabidopsis thaliana	78-84
33640883-6	2021	Consistently, Maf1 knockdown activates ATF5-transcription of mtHSP70 and HSP60, enhances mitochondrial membrane potential, reduces intracellular ROS levels and dampens rapamycin"s effect on increasing IR-mediated cytotoxicity.	ros	145-148	MAF1 homolog, negative regulator of RNA polymerase III	Homo sapiens	14-18
33540838-0	2021	Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction.	ros	108-111	ATM serine/threonine kinase	Homo sapiens	32-35
33540838-6	2021	Importantly, we found that HIF-2alpha acts as a key mediator that potentiates the response to combined CK2/ATM inhibition by triggering ROS-dependent apoptosis.	ros	136-139	endothelial PAS domain protein 1	Homo sapiens	27-37
33540838-6	2021	Importantly, we found that HIF-2alpha acts as a key mediator that potentiates the response to combined CK2/ATM inhibition by triggering ROS-dependent apoptosis.	ros	136-139	ATM serine/threonine kinase	Homo sapiens	107-110
33359261-7	2021	These cells showed increased proton leak and uncoupling protein 3 (UCP3) expression that correlated with mitochondrial ROS (mROS) accumulation, mitochondrial membrane potential (MMP) depolarization and expression of PD1.	ros	119-122	uncoupling protein 3	Sus scrofa	67-71
33345387-11	2021	In addition, we verified that DIAPH3 could down-regulate cellular ROS level via up-regulating TrxR1 expression.	ros	66-69	diaphanous related formin 3	Homo sapiens	30-36
33355373-8	2021	Furthermore, miR-126 mimics decreased ROS generation and malondialdehyde content, and increased superoxide dismutase and glutathione peroxidase activity in HUVECs exposed to OGD/R, and these effects of miR-126 mimics were also blocked by SIRT1-siRNA.	ros	38-41	microRNA 126	Homo sapiens	13-20
33395583-6	2021	ZmEREB20 overexpression lines also showed higher survival rates with elevated ROS scavenging toward high salinity.	ros	78-81	uncharacterized LOC100193098	Zea mays	0-8
33395583-9	2021	ZmEREB20 positively regulated salt tolerance through the molecular mechanism associated with hormone signaling, ROS scavenging and root hair plasticity, proving the potential target for crop breeding to improve salt resistance.	ros	112-115	uncharacterized LOC100193098	Zea mays	0-8
32974855-10	2021	Additionally, the levels of ROS, MDA, and SOD were elevated upon Nesfatin-1 knockdown.	ros	28-31	nucleobindin 2	Homo sapiens	65-75
33509753-13	2021	CONCLUSIONS: Hepatocytes-specific NDUFA13 ablation can trigger spontaneous hepatitis in mice possibly mediated by the activation of ROS/NF-kappaB/NLRP3 signaling.	ros	132-135	NLR family, pyrin domain containing 3	Mus musculus	146-151
33501731-0	2021	Photobiomodulation Therapy for Thrombocytopenia by Upregulating Thrombopoietin Expression via the ROS-dependent Src/ERK/STAT3 Signaling Pathway.	ros	98-101	Rous sarcoma oncogene	Mus musculus	112-115
33708107-8	2020	Moreover, autophagy inhibitors, ROS scavenger, Ca2+ chelator and NF-kappaB inhibitor remarkably suppressed c-Fos and NFATc1 expressions.	ros	32-35	nuclear factor of activated T-cells 1	Rattus norvegicus	117-123
32660255-5	2021	The inhibition of Cdk5 also ameliorated mitochondrial dysfunction by decreasing ROS levels and cytochrome c release, while increasing ATP production.	ros	80-83	cyclin dependent kinase 5	Homo sapiens	18-22
33314701-6	2021	OMA1-OPA1 axis is activated by hypoxia, increasing mitochondrial ROS to stabilize HIF-1alpha, thereby promoting glycolysis in colorectal cancer cells.	ros	65-68	OMA1 zinc metallopeptidase	Mus musculus	0-4
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	ros	52-55	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	92-96
32478624-2	2021	Parthanatos is a cell death form involving ROS and AIF, which is induced by poly (ADP-ribose) polymerase-1 (PARP-1).	ros	43-46	poly (ADP-ribose) polymerase 1	Rattus norvegicus	76-106
32478624-2	2021	Parthanatos is a cell death form involving ROS and AIF, which is induced by poly (ADP-ribose) polymerase-1 (PARP-1).	ros	43-46	poly (ADP-ribose) polymerase 1	Rattus norvegicus	108-114
32368968-6	2021	The adaptive induction of white adipose tissues (WAT) to beige adipose tissues (beAT) showed the beneficial effects on glucose oxidation, ROS protection, and mitochondrial function preservation through the uncoupling protein 1 (UCP1)-independent thermogenesis of beAT.	ros	138-141	uncoupling protein 1	Homo sapiens	228-232
33254415-10	2021	B(a)P or BPDE-treated alone impaired antioxidant capacity of ovarian granulosa cells, caused an increasing of ROS and cell apoptosis, and disrupted the PI3K/AKT/GSK3beta signaling pathway in vivo and in vitro.	ros	110-113	prohibitin 2	Mus musculus	0-5
33091478-5	2021	Potent ROS/photothermal combinational therapeutic effects were exhibited by the bioinspired FU-Ppy NP through a selective P-selectin cancer/tumor targeting aptitude for the lung cancer cells/tumor compared with other nano-formulations.	ros	7-10	selectin P	Homo sapiens	122-132
32996079-0	2021	Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies.	ros	28-31	ATM serine/threonine kinase	Homo sapiens	14-17
32996079-7	2021	We used A-T cells overexpressed with WT or S1981A (auto-phosphorylation dead) ATM plasmids and show that ATM is activated by ROS-induced oxidative stress emanating from ionophore-induced mitochondrial damage and mitophagy.	ros	125-128	ATM serine/threonine kinase	Homo sapiens	78-81
32996079-7	2021	We used A-T cells overexpressed with WT or S1981A (auto-phosphorylation dead) ATM plasmids and show that ATM is activated by ROS-induced oxidative stress emanating from ionophore-induced mitochondrial damage and mitophagy.	ros	125-128	ATM serine/threonine kinase	Homo sapiens	105-108
32996079-9	2021	Our data suggest that while ATM kinase does not participate in mitophagy, it is activated via elevated ROS.	ros	103-106	ATM serine/threonine kinase	Homo sapiens	28-31
33171331-0	2021	Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling.	ros	63-66	CD274 molecule	Homo sapiens	14-19
33171331-5	2021	We further showed that exogenous ROS such as hydrogen peroxide alone was sufficient to activate FGFR1 and induce PD-L1, while antioxidants could largely abrogate PD-L1 expression in K-ras mutant cells, indicating a critical role of redox regulation.	ros	33-36	CD274 molecule	Homo sapiens	113-118
33171331-7	2021	Our study has identified a novel mechanism by which K-ras promotes PD-L1 expression, and suggests that modulation of ROS or inhibition of the FGFR1 pathway could be a novel strategy to abrogate PD-L1-mediated immunosuppression and thus potentially improve the efficacy of immunotherapy in K-ras-driven cancers.	ros	117-120	CD274 molecule	Homo sapiens	194-199
33488293-5	2020	Importantly, MCPIP-1 markedly downregulated the production of ROS, MPO, and proinflammatory cytokines (e.g., interleukin-1beta, interleukin-6, tumor necrosis factor-alpha, interleukin-8, and interferon-gamma) and suppressed the migration of IBD neutrophils.	ros	62-65	zinc finger CCCH-type containing 12A	Homo sapiens	13-20
33206581-12	2021	Taken together, these results indicated that autophagy activation and modulation of ROS production mediated via the HIF1A-HMOX1 axis play pivotal roles in enhancing the viability of MSC3D.	ros	84-87	hypoxia inducible factor 1, alpha subunit	Mus musculus	116-121
33172542-0	2020	Anti-inflammatory mechanisms of suppressors of cytokine signaling target ROS via NRF-2/thioredoxin induction and inflammasome activation in macrophages.	ros	73-76	thioredoxin	Homo sapiens	87-98
33172542-2	2020	Since ROS acts as a critical mediator of inflammation, we have investigated the anti-inflammatory mechanisms of SOCS via ROS regulation in monocytic/macrophagic cells.	ros	121-124	cytokine inducible SH2 containing protein	Homo sapiens	112-116
33225802-8	2020	Blocking the DDR using DNA-PK or AKT inhibitors enhanced cellular sensitivity to radiation and facilitated myofibroblast induction, whereas an ATM inhibitor also enhanced radiation sensitivity but abrogated ROS accumulation and myofibroblast induction.	ros	207-210	ATM serine/threonine kinase	Homo sapiens	143-146
33275652-6	2020	Subsequently, the role and molecular mechanism of NKA/Src in ROS stress signaling were evaluated biochemically in the retinas of mice exposed to the well-established protocol of oxygen-induced retinopathy (OIR).	ros	61-64	Rous sarcoma oncogene	Mus musculus	54-57
33045248-4	2020	We showed that deletion of MED2 leads to sensitivity to the ER stress inducer tunicamycin (TM) as well as a shortened replicative lifespan (RLS), accompanied by increased intracellular ROS levels and hyperpolarization of mitochondria.	ros	185-188	Med2p	Saccharomyces cerevisiae S288C	27-31
32947010-8	2020	Notably, overexpression of PINK1 in vivo attenuated hepatic I/R injury, ROS production, NLRP3 activation and hepatic inflammation.	ros	72-75	PTEN induced putative kinase 1	Mus musculus	27-32
32629061-6	2020	alpha-Synuclein fibrils formed in the presence of copper/iron ions were more cytotoxic, causing increased ROS production, cell apoptosis, and shortened the lifespan of a C. elegans PD model overexpressing human alpha-synuclein.	ros	106-109	synuclein alpha	Homo sapiens	0-15
33146789-10	2021	In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy.	ros	23-26	C-C motif chemokine ligand 2	Homo sapiens	183-188
32975326-5	2020	RESULTS: Our study first verified that conditional knockout of HIF-1alpha worsened tubular injury in DN; additionally, aggravated kidney dysfunction, renal histopathological alterations, mitochondrial fragmentation, ROS accumulation and apoptosis were observed in diabetic PT-HIF-1alpha-/- mice.	ros	216-219	hypoxia inducible factor 1, alpha subunit	Mus musculus	63-73
32920196-10	2020	In addition, FABP4 knockdown promoted fatty acid oxidation and ROS production, which result in the activation of ER stress.	ros	63-66	fatty acid binding protein 4, adipocyte	Mus musculus	13-18
33010604-12	2020	CONCLUSION: In summary, miR-124-3p is upregulated in PE, and in vitro functional analysis revealed that this mRNA inhibits trophoblast invasion and migration but promotes cell pyroptosis partly via the PLGF-ROS pathway.	ros	207-210	microRNA 124-3	Homo sapiens	24-34
33019842-5	2021	We found that nuclear-aggregated PRCC-TFE3 fusions constitutively activated expression of the target gene E3 ubiquitin ligase PRKN, leading to rapid PINK1-PRKN-dependent mitophagy that promoted cell survival under mitochondrial oxidative damage as well as cell proliferation through decreasing mitochondrial ROS formation.	ros	308-311	proline rich mitotic checkpoint control factor	Homo sapiens	33-37
33019842-5	2021	We found that nuclear-aggregated PRCC-TFE3 fusions constitutively activated expression of the target gene E3 ubiquitin ligase PRKN, leading to rapid PINK1-PRKN-dependent mitophagy that promoted cell survival under mitochondrial oxidative damage as well as cell proliferation through decreasing mitochondrial ROS formation.	ros	308-311	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	126-130
33019842-5	2021	We found that nuclear-aggregated PRCC-TFE3 fusions constitutively activated expression of the target gene E3 ubiquitin ligase PRKN, leading to rapid PINK1-PRKN-dependent mitophagy that promoted cell survival under mitochondrial oxidative damage as well as cell proliferation through decreasing mitochondrial ROS formation.	ros	308-311	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	155-159
33046439-13	2021	Additionally, an increase in the ROS level was prohibited in HG-treated podocytes with the knockdown of Nox4, Smad3, or ezrin.	ros	33-36	ezrin	Homo sapiens	120-125
33046439-14	2021	Taken together, our findings provided evidence that Smad3-mediated ezrin activation upregulates Nox4 expression and ROS production, by suppressing PKA activity, which may at least in part contribute to HG-induced podocyte apoptosis.	ros	116-119	ezrin	Homo sapiens	67-72
32840960-6	2020	POLG-driven mitochondrial dysfunction led to neuronal ROS overproduction and increased cellular senescence.	ros	54-57	DNA polymerase gamma, catalytic subunit	Homo sapiens	0-4
32897801-11	2020	Moreover, circMAT2B knockdown could effectively decrease OGD-induced the increasing of apoptosis, ROS generation and the expression of IL-1beta, IL-6 and TNF-alpha.	ros	98-101	methionine adenosyltransferase 2B	Rattus norvegicus	10-19
32470744-8	2020	Moreover, DAF-16 acted upstream of LGG-1, an ortholog of Atg8/LC3, to regulate the toxicity of nanopolystyrene toxicity in inducing ROS production and in decreasing locomotion behavior at adult day-9.	ros	132-135	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	10-16
32607763-8	2020	And ROS stimulation activated the NLRP3 inflammasome which was inhibited by thioredoxin-1.	ros	4-7	NLR family, pyrin domain containing 3	Mus musculus	34-39
32683165-7	2020	To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC.	ros	19-22	synuclein alpha	Homo sapiens	99-102
32683165-7	2020	To our surprising, ROS level was increased by compound 4o and elevation of ROS could be rescued by NAC.	ros	75-78	synuclein alpha	Homo sapiens	99-102
32712192-2	2020	Soluble alpha-synuclein-Cu(II) complexes possess dopamine oxidase activity and catalyze ROS production in the presence of biological reducing agents via Cu(II)/Cu(I) redox cycling.	ros	88-91	synuclein alpha	Homo sapiens	8-23
10656529-8	1999	The COX activity shown by NF-kappaB activation and the ROS generation by COX-mediated process were all modulated by DR. Our results suggest that the upregulation of COX-2 during aging may play an important role in many age-related diseases associated with aging process.	ros	55-58	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	165-170
32808659-8	2020	Moreover, LPS treatment induced ROS production and apoptosis in kidney HK-2 cells as well as in the mouse kidney, which were mitigated by ELA or Fc-ELA treatment.	ros	32-35	apelin receptor early endogenous ligand	Mus musculus	138-141
33003464-8	2020	rho- petites expressing alpha-synuclein from fully-induced MET25/GAL1 promoters exhibit increased ROS levels, loss of mitochondrial membrane potential, and nuclear DNA fragmentation, with increasing copies of alpha-synuclein.	ros	98-101	synuclein alpha	Homo sapiens	24-39
9792712-2	1998	In osteoblastic ROS 17/2.8 cells, 1,25-(OH)2-vitamin D3 stimulates transcription of the extracellular matrix phosphoprotein osteopontin (OPN).	ros	16-19	secreted phosphoprotein 1	Rattus norvegicus	124-135
32973326-0	2021	Sodium propionate exerts anticancer effect in mice bearing breast cancer cell xenograft by regulating JAK2/STAT3/ROS/p38 MAPK signaling.	ros	113-116	Janus kinase 2	Mus musculus	102-106
9792712-2	1998	In osteoblastic ROS 17/2.8 cells, 1,25-(OH)2-vitamin D3 stimulates transcription of the extracellular matrix phosphoprotein osteopontin (OPN).	ros	16-19	secreted phosphoprotein 1	Rattus norvegicus	137-140
9792712-5	1998	Loading equal amounts of OPN recovered from ROS 17/2.8 cells exposed to 1,25-(OH)2D3 or carrier for 3 h reveals that the pI shift represents reduced phosphorylation.	ros	44-47	secreted phosphoprotein 1	Rattus norvegicus	25-28
9774423-0	1998	Stat3 plays an important role in oncogenic Ros- and insulin-like growth factor I receptor-induced anchorage-independent growth.	ros	43-46	signal transducer and activator of transcription 3	Bos taurus	0-5
32887693-15	2020	Our findings strongly suggest that the regulation of SUMO conjugation to alpha-synuclein can be a novel therapeutic target to prevent the formation of Lewy bodies and ROS generation.	ros	167-170	synuclein, alpha	Mus musculus	73-88
33106217-0	2020	Anti-cancer Effect of 20(S)-Ginsenoside-Rh2 on Oral Squamous Cell Carcinoma Cells via the Decrease in ROS and Downregulation of MMP-2 and VEGF.	ros	102-105	Rh associated glycoprotein	Homo sapiens	40-43
9774423-6	1998	We conclude that activated function of Stat3 is required for the establishment and maintenance of Ros and insulin-like growth factor I receptor PTK-induced cell transformation.	ros	98-101	signal transducer and activator of transcription 3	Bos taurus	39-44
9312203-3	1997	Like hPTH-(1-31)NH2, hPTHrP-(1-31)NH2 stimulated adenyly cyclase in ROS 17/2 osteosarcoma cells as strongly as the standard hPTH-(1-34) and like hPTH-(1-31)NH2, triggered a large drop in mean blood pressure when injected intravenously.	ros	68-71	parathyroid hormone like hormone	Homo sapiens	21-27
32802722-0	2020	MAPK Enzymes: a ROS Activated Signaling Sensors Involved in Modulating Heat Stress Response, Tolerance and Grain Stability of Wheat under Heat Stress.	ros	16-19	probable serine/threonine-protein kinase WNK4	Nicotiana tabacum	0-4
32242118-5	2020	We found that RIP1 KO suppressed cisplatin-induced ROS accumulation in both SKOV3 and A2780 cells.	ros	51-54	receptor interacting serine/threonine kinase 1	Homo sapiens	14-18
32592929-2	2020	We used flow cytometry analysis to identify a Lampetra morii homologue of PHB2 (Lm-PHB2) that could significantly decrease the levels of ROS generation in HEK293T cells.	ros	137-140	prohibitin 2	Homo sapiens	74-78
32592929-2	2020	We used flow cytometry analysis to identify a Lampetra morii homologue of PHB2 (Lm-PHB2) that could significantly decrease the levels of ROS generation in HEK293T cells.	ros	137-140	prohibitin 2	Homo sapiens	80-87
32592929-7	2020	The above mentioned results indicate that Lm-PHB2 could assist OPA1 and HAX1 to maintain mitochondrial morphology and decrease ROS levels by the translocation from the nucleus to mitochondria under oxidative stress.	ros	127-130	prohibitin 2	Homo sapiens	42-49
33042327-9	2020	ROS scavenger NAC was used to inhibit increased ROS caused by the SPR knockdown.	ros	0-3	synuclein alpha	Homo sapiens	14-17
33042327-9	2020	ROS scavenger NAC was used to inhibit increased ROS caused by the SPR knockdown.	ros	48-51	synuclein alpha	Homo sapiens	14-17
32738790-4	2020	Here we establish an experimental system in mammalian cells that allows us to probe the influence of heme availability on ROS production by NOX5.	ros	122-125	NADPH oxidase 5	Homo sapiens	140-144
32946102-10	2020	CONCLUSION: To our knowledge, this is the first study to investigate the AOPP levels in the CLP sepsis model, ROS produced by the reaction of MPO derived from neutrophils may form oxidative damage to the proteins, compared to the lipids, and ss-glucan may be used as an alternative agent for sepsis treatment.	ros	110-113	myeloperoxidase	Rattus norvegicus	142-145
32407842-12	2020	In addition, knockdown of APPL1 in HTR-8/SVneo cells resulted in increased ROS and apoptosis, which could be rescued by pretreatment with antioxidants.	ros	75-78	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	26-31
32848827-9	2020	Thereby, our model indicates that TP53 activity is balanced depending on external stimulations, engaging a regulatory mechanism involving ROS regulators and RAS activated transcription factors.	ros	138-141	transformation related protein 53	Mus musculus	34-38
9283616-6	1997	With regard to ROS, all subsets expressed CD44, and macrophage and dendritic cell ROS were also ICAM-1-positive and LFA-1-positive.	ros	82-85	intercellular adhesion molecule 1	Mus musculus	96-102
9182583-9	1997	TIMP-4 and TIMP-2 but not TIMP-1 bound specifically to purified TIMP-2-free human recombinant full-length progelatinase A and to full-length rat proenzyme from the conditioned culture medium of ROS 17/2.8 cells.	ros	194-197	TIMP metallopeptidase inhibitor 4	Homo sapiens	0-6
8858096-1	1996	The effects of a 15-mer antisense c-myc phosphorothioate modified oligodeoxynucleotide (OdN) upon the volume-sensitive Cl- current in ROS 17/2.8 cells were investigated using the whole-cell configuration of the patch clamp technique.	ros	134-137	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	34-39
8799135-1	1996	A constitutively active form of fibroblast growth factor 2 (FGFR2) was identified in rat osteosarcoma (ROS) cells by an expression cloning strategy.	ros	103-106	fibroblast growth factor 2	Rattus norvegicus	32-58
8799135-1	1996	A constitutively active form of fibroblast growth factor 2 (FGFR2) was identified in rat osteosarcoma (ROS) cells by an expression cloning strategy.	ros	103-106	fibroblast growth factor 2	Rattus norvegicus	60-65
8799135-4	1996	FGFR2-ROS is expressed as a unusually large protein and is highly phosphorylated in NIH 3T3 transfectants.	ros	6-9	fibroblast growth factor 2	Rattus norvegicus	0-5
8799135-7	1996	The highly activated state of FGFR2-ROS appears to be attributed to constitutive dimer formation and higher phosphorylation level as well as possibly altered subcellular localization.	ros	36-39	fibroblast growth factor 2	Rattus norvegicus	30-35
8647314-2	1996	In view of the critical role of 1,25(OH)2D3 on bone metabolism, it has been investigated if ROS 17/2.8 osteoblastic cells were able to express the nerve growth factor (NGF) gene and if this process was responsive to 1,25(OH)2D3.	ros	92-95	nerve growth factor	Rattus norvegicus	147-166
32709884-11	2021	EGR1 was down-regulated by miR-124-3p, and siEGR1 was able to inhibit apoptosis and ROS production of cell model.	ros	84-87	early growth response 1	Homo sapiens	0-4
32709884-12	2021	In the final rescue experiments, miR-124-3p partially reversed the effect of Ang-II on the viability, migration, invasion and apoptosis and ROS production in HUVECs by down-regulating EGR1.	ros	140-143	microRNA 124-3	Homo sapiens	33-43
32709884-12	2021	In the final rescue experiments, miR-124-3p partially reversed the effect of Ang-II on the viability, migration, invasion and apoptosis and ROS production in HUVECs by down-regulating EGR1.	ros	140-143	early growth response 1	Homo sapiens	184-188
32709884-13	2021	MiR-124-3p inhibits Ang II-induced apoptosis and ROS production in HUVECs by down-regulating EGR1.	ros	49-52	microRNA 124-3	Homo sapiens	0-10
32658903-8	2020	In addition, PKClambda knockdown led to increases in cellular ROS levels in ALDH1high cells.	ros	62-65	aldehyde dehydrogenase 1 family member A1	Homo sapiens	76-81
8647314-2	1996	In view of the critical role of 1,25(OH)2D3 on bone metabolism, it has been investigated if ROS 17/2.8 osteoblastic cells were able to express the nerve growth factor (NGF) gene and if this process was responsive to 1,25(OH)2D3.	ros	92-95	nerve growth factor	Rattus norvegicus	168-171
8647314-4	1996	However, the phorbol ester PMA, previously reported to augment the synthesis of NGF via the recruitment of AP-1 complexes, depressed the expression of the NGF gene in ROS cells.	ros	167-170	nerve growth factor	Rattus norvegicus	80-83
32733468-10	2020	This effect was reversed by NOX5 inhibition, but not NOX2, resulting in suppression of NOX5-dependent ROS production.	ros	102-105	NADPH oxidase 5	Homo sapiens	28-32
8647314-4	1996	However, the phorbol ester PMA, previously reported to augment the synthesis of NGF via the recruitment of AP-1 complexes, depressed the expression of the NGF gene in ROS cells.	ros	167-170	nerve growth factor	Rattus norvegicus	155-158
32874469-12	2020	The exposure to hyperbaric oxygen at the pressure of 2.4 ATAand 98% oxygen wasable to produce ROS and RNS molecules, which play a role in cellular adaptive responses through increasing the expression of nfkb, p21 and mRNA of interferon alpha2 plays a role in inhibition mechanism of HIV-1 replication in cells.	ros	94-97	H3 histone pseudogene 16	Homo sapiens	209-212
8647314-6	1996	Binding of 125I-NGF to ROS cells displayed the properties of a low affinity NGF receptor (dissociation constant Kd approximately 10(-9) M).	ros	23-26	nerve growth factor	Rattus norvegicus	16-19
8647314-6	1996	Binding of 125I-NGF to ROS cells displayed the properties of a low affinity NGF receptor (dissociation constant Kd approximately 10(-9) M).	ros	23-26	nerve growth factor receptor	Rattus norvegicus	63-88
8647314-7	1996	In agreement with this result, the mRNA encoding the low affinity NGF receptor (LNGFR) was detected in ROS 17/2.8 cells, unlike trkA transcripts which encode the high affinity receptor.	ros	103-106	nerve growth factor receptor	Rattus norvegicus	66-78
8647314-7	1996	In agreement with this result, the mRNA encoding the low affinity NGF receptor (LNGFR) was detected in ROS 17/2.8 cells, unlike trkA transcripts which encode the high affinity receptor.	ros	103-106	nerve growth factor receptor	Rattus norvegicus	80-85
7622587-2	1995	Reactive O2 species (ROS) have been implicated in the pathogenesis of hypoxic and reoxygenation lung injury, and xanthine dehydrogenase/oxidase (XDH/XO) is a major generator of the ROS.	ros	21-24	xanthine dehydrogenase	Homo sapiens	145-148
32490497-8	2020	Pterostilbene inhibited phosphorylated-IkappaBalpha expression, thus promoting IkappaBalpha expression and inhibiting ROS overexpression.	ros	118-121	NFKB inhibitor alpha	Rattus norvegicus	39-51
32577129-6	2020	These changes, attributed to either direct UV-C-, ROS- or redox unbalances-associated damage, trigger a response process involving novel signaling intermediaries and effectors such as the translation modulator FAP204, a PP2A-like protein and a novel DYRK kinase.	ros	50-53	uncharacterized protein	Chlamydomonas reinhardtii	210-216
7622587-2	1995	Reactive O2 species (ROS) have been implicated in the pathogenesis of hypoxic and reoxygenation lung injury, and xanthine dehydrogenase/oxidase (XDH/XO) is a major generator of the ROS.	ros	181-184	xanthine dehydrogenase	Homo sapiens	113-143
32143837-7	2020	SIGNIFICANCE: hPMSCs downregulated ROS generation by increasing GSH and GST levels and further reduced the expression of PD-1 on T cells, thereby alleviating inflammation in GVHD mice.	ros	35-38	hematopoietic prostaglandin D synthase	Mus musculus	72-75
7622587-2	1995	Reactive O2 species (ROS) have been implicated in the pathogenesis of hypoxic and reoxygenation lung injury, and xanthine dehydrogenase/oxidase (XDH/XO) is a major generator of the ROS.	ros	181-184	xanthine dehydrogenase	Homo sapiens	145-148
7622587-9	1995	The absence of XDH/XO may prevent porcine PAEC from developing injury and increased ROS production during reoxygenation.	ros	84-87	xanthine dehydrogenase	Homo sapiens	15-18
7642714-11	1995	Transfection of Cx45tr and Cx45 had different effects in ROS cells, consistent with a role of the carboxyl-terminal domain of Cx45 in determining gap junction permeability or interactions between connexins.	ros	57-60	gap junction protein, gamma 1	Rattus norvegicus	16-20
32203884-8	2020	ROS metabolism contributed 13% (glutathione S-transferase, ascorbate peroxidase, and thioredoxin), and 9% for signal transduction (actin-101, and 14-3-3-like protein B).	ros	0-3	L-ascorbate peroxidase, cytosolic	Cicer arietinum	32-79
32229256-6	2020	Out of many antioxidant candidates, N-acetyl-L-cysteine (a prodrug of L-cysteine) (NAC) is a potent antioxidant as the bioavailability of the parent drug, L-cysteine, determines the production of glutathione; the universal antioxidant that regulates ROS.	ros	250-253	synuclein alpha	Homo sapiens	83-86
7642714-11	1995	Transfection of Cx45tr and Cx45 had different effects in ROS cells, consistent with a role of the carboxyl-terminal domain of Cx45 in determining gap junction permeability or interactions between connexins.	ros	57-60	gap junction protein, gamma 1	Rattus norvegicus	27-31
7642714-11	1995	Transfection of Cx45tr and Cx45 had different effects in ROS cells, consistent with a role of the carboxyl-terminal domain of Cx45 in determining gap junction permeability or interactions between connexins.	ros	57-60	gap junction protein, gamma 1	Rattus norvegicus	27-31
32509142-6	2020	Cardiomyocytes exposed to high glucose/high palmitic acid exhibited increases in intracellular ROS, apoptosis, and autophagosomes, and these increases were robustly prevented by PK2.	ros	95-98	prokineticin 2	Rattus norvegicus	178-181
7572312-9	1995	Indirect immunofluorescence with antibodies to Cx43 revealed that ROS 17/2.8, ROB, and to a lesser extent MC3T3-E1 and UMR-106, expressed Cx43 immunoreactivity.	ros	66-69	gap junction protein alpha 1	Homo sapiens	47-51
32396064-4	2020	Upon M1 stimulation, myeloid-specific Bmal1 knockout (M-BKO) renders macrophages unable to sustain mitochondrial function, enhancing succinate dehydrogenase (SDH)-mediated mitochondrial ROS production and Hif-1a-dependent metabolic reprogramming and inflammatory damage.	ros	186-189	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	38-43
32396064-4	2020	Upon M1 stimulation, myeloid-specific Bmal1 knockout (M-BKO) renders macrophages unable to sustain mitochondrial function, enhancing succinate dehydrogenase (SDH)-mediated mitochondrial ROS production and Hif-1a-dependent metabolic reprogramming and inflammatory damage.	ros	186-189	aminoadipate-semialdehyde synthase	Mus musculus	133-156
32396064-4	2020	Upon M1 stimulation, myeloid-specific Bmal1 knockout (M-BKO) renders macrophages unable to sustain mitochondrial function, enhancing succinate dehydrogenase (SDH)-mediated mitochondrial ROS production and Hif-1a-dependent metabolic reprogramming and inflammatory damage.	ros	186-189	aminoadipate-semialdehyde synthase	Mus musculus	158-161
32143825-8	2020	The ANT activation was observed with a rise in ROS production, inhibition of the mitochondrial respiration, decrease in the complex III protein and rise in mitophagy activity.	ros	47-50	solute carrier family 25 member 6	Homo sapiens	4-7
7572312-9	1995	Indirect immunofluorescence with antibodies to Cx43 revealed that ROS 17/2.8, ROB, and to a lesser extent MC3T3-E1 and UMR-106, expressed Cx43 immunoreactivity.	ros	66-69	gap junction protein alpha 1	Homo sapiens	138-142
32440120-5	2020	When investigating the mechanisms of cadmium-containing QDs causing IL-1ss-mediated inflammation, the findings suggested that cadmium-containing QDs activated the NLRP3 inflammasome by causing excessive ROS generation, and resulted in IL-1ss release.	ros	203-206	NLR family, pyrin domain containing 3	Mus musculus	163-168
7870034-8	1995	These data indicate that ROS osteoblasts display both ETA and ETB receptors that are functional.	ros	25-28	endothelin receptor type A	Rattus norvegicus	54-57
7870034-8	1995	These data indicate that ROS osteoblasts display both ETA and ETB receptors that are functional.	ros	25-28	endothelin receptor type B	Rattus norvegicus	62-65
32375631-13	2020	MiR-215 mimics also caused inhibition of oxidative stress as evidenced by suppression of ROS, MDA and LDH levels as well as increase of SOD level.	ros	89-92	microRNA 215	Rattus norvegicus	0-7
7565445-4	1995	The functional significance of the cAMP effect is unknown, but preliminary findings indicated that PTHrP(107-139) also inhibited osteopontin mRNA levels in ROS 17/2.8 cells treated with peptide for 48 h. The results suggest that the carboxy-terminal region of PTHrP may play a role in bone metabolism by influencing osteoblast activity.	ros	156-159	secreted phosphoprotein 1	Rattus norvegicus	129-140
32184231-5	2020	By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced ROS production and F-actin defects at the wound edge, culminating in wound healing impairment.	ros	217-220	dynamin 1 like	Homo sapiens	85-110
32184231-5	2020	By live-imaging, we found that loss of function of the mitochondrial fission protein Dynamin-related protein 1 (Drp1) compromises the increase of cytosolic and mitochondrial calcium upon wounding and leads to reduced ROS production and F-actin defects at the wound edge, culminating in wound healing impairment.	ros	217-220	dynamin 1 like	Homo sapiens	112-116
7930994-6	1994	Bioactive PTHrP(1-34) was detected in placenta, chorion and amnion using the ROS cell bioassay.	ros	77-80	parathyroid hormone like hormone	Homo sapiens	10-15
32292063-8	2020	Together, these results suggest that ss-cells utilize cytoplasmic Prdx1 as a primary defense mechanism against both ROS and RNS.	ros	116-119	peroxiredoxin 1	Rattus norvegicus	66-71
8300629-8	1994	Gel retardation assays with ROS 17/2.8 nuclear extracts suggest that the VDR binds to the mouse osteopontin VDRE predominantly as a heterodimer with retinoid X receptor(s) (RXR(s)).	ros	28-31	secreted phosphoprotein 1	Mus musculus	96-107
32398966-10	2020	By using ROS scavenger N-acetyl-cysteine (NAC) could reverse the effects of nicotine by down-regulation the phosphorylation of p38MAPK and JNK pathways, and pretreatment of specific inhibitors of p38MAPK and JNK could restore the autophagy impairment and cardiomyocytes hypertrophy induced by nicotine.	ros	9-12	mitogen-activated protein kinase 8	Rattus norvegicus	139-142
32398966-10	2020	By using ROS scavenger N-acetyl-cysteine (NAC) could reverse the effects of nicotine by down-regulation the phosphorylation of p38MAPK and JNK pathways, and pretreatment of specific inhibitors of p38MAPK and JNK could restore the autophagy impairment and cardiomyocytes hypertrophy induced by nicotine.	ros	9-12	mitogen-activated protein kinase 8	Rattus norvegicus	208-211
32398966-12	2020	Cilostazol also inhibited the ROS accumulation and the activation of p38MAPK and JNK, which providing novel connection between lysosome CTSB and ROS/p38MAPK/JNK related oxidative stress pathway.	ros	145-148	mitogen-activated protein kinase 8	Rattus norvegicus	81-84
32191437-5	2020	In our research, we found that laquinimod could ameliorate IL-1beta-induced generation of ROS and improve mitochondrial function by increasing mitochondrial membrane potential (DeltaPsim).	ros	90-93	interleukin 1 alpha	Homo sapiens	59-67
32377291-8	2020	Moreover, Cav-1-deficient PSCs accumulated ROS to enhance the shh pathway and angiogenesis in pancreatic cancer cells.	ros	43-46	sonic hedgehog signaling molecule	Homo sapiens	62-65
32195489-0	2020	Activation of AMPK/Sirt3 pathway by phloretin reduces mitochondrial ROS in vascular endothelium by increasing the activity of MnSOD via deacetylation.	ros	68-71	sirtuin 3	Mus musculus	19-24
31830513-11	2020	Collectively, these findings indicated that autophagy/mitophagy elevation caused by SIRT1/PGC-1alpha pathway activation might be a protective mechanism to increase tight junction integrity against oxidative stress-mediated ROS production in IPEC-1 cells.	ros	223-226	PPARG coactivator 1 alpha	Sus scrofa	90-100
32121588-1	2020	Mevastatin (MVS) has been previously shown to induce heme oxygenase (HO)-1 expression through Nox/ROS-dependent PDGFRalpha/PI3K/Akt/Nrf2/ARE axis in human pulmonary alveolar epithelial cells (HPAEpiCs).	ros	98-101	heme oxygenase 1	Homo sapiens	53-74
32015486-7	2020	Consistent with this result, ALDH1/3 disruption synergized with ROS-inducing agents or glutathione synthesis inhibitors to trigger cell death.	ros	64-67	aldehyde dehydrogenase 1 family member A1	Homo sapiens	29-36
32104690-6	2020	Additionally, we noted that the ROS level was significantly enhanced in PCK1-deficient strain and decreased in PCK1 OE strain.	ros	32-35	phosphoenolpyruvate carboxykinase PCK1	Saccharomyces cerevisiae S288C	72-76
33132325-10	2020	Accordingly, it is expected that treatment with XOR and URAT1 inhibitors will effectively decrease purine pools in the body and prevent cell injury due to ROS generated during XOR-mediated reactions.	ros	155-158	solute carrier family 22 member 12	Canis lupus familiaris	56-61
32954380-15	2020	The expression of antioxidant enzymes, SOD1, was reduced in HHT1 MNCs, which was accompanied with an increase of ROS in HHT MNCs and nitric oxide in HHT1 plasma.	ros	113-116	endoglin	Homo sapiens	60-64
31751569-13	2020	Mitochondrial ROS were increased by Trx2 deletion and importantly, mitochondria-specific ROS scavenger MitoTEMPO suppressed HDAC4 elevation, HCN4 reduction, and sinus bradycardia in Trx2ccsKO mice.	ros	14-17	thioredoxin 2	Mus musculus	36-40
31751569-13	2020	Mitochondrial ROS were increased by Trx2 deletion and importantly, mitochondria-specific ROS scavenger MitoTEMPO suppressed HDAC4 elevation, HCN4 reduction, and sinus bradycardia in Trx2ccsKO mice.	ros	14-17	thioredoxin 2	Mus musculus	182-186
31751569-13	2020	Mitochondrial ROS were increased by Trx2 deletion and importantly, mitochondria-specific ROS scavenger MitoTEMPO suppressed HDAC4 elevation, HCN4 reduction, and sinus bradycardia in Trx2ccsKO mice.	ros	89-92	thioredoxin 2	Mus musculus	182-186
31751569-15	2020	Loss of Trx2 reduces HCN4 expression via a mitochondrial ROS-HDAC4-MEF2C pathway and subsequently induces sick sinus syndrome in mice.	ros	57-60	thioredoxin 2	Mus musculus	8-12
31918235-12	2020	Addition of NAC prevents ROS in the cultured SH-SY5Y cells and prevents the cells from the apoptosis.	ros	25-28	synuclein alpha	Homo sapiens	12-15
31714069-3	2019	It was discovered that HTF-1 dose dependently induced overproduction of ROS in HeLa cells, and the cell viability can be rescued when adding ROS scavenger N-acetyl-l-cysteine (NAC).	ros	72-75	zinc finger protein 85	Homo sapiens	23-28
31714069-3	2019	It was discovered that HTF-1 dose dependently induced overproduction of ROS in HeLa cells, and the cell viability can be rescued when adding ROS scavenger N-acetyl-l-cysteine (NAC).	ros	141-144	zinc finger protein 85	Homo sapiens	23-28
31714069-4	2019	More, we found that HTF-1 induced ROS-independent autophagy in concentration- and time-dependent manners in HeLa cells.	ros	34-37	zinc finger protein 85	Homo sapiens	20-25
30963789-5	2019	Importantly, our results indicate that blockage of RIP1 using its specific antagonist necrostatin-1 (Nec-1) ameliorated HBx-induced oxidative stress by mitigating the production of ROS and Nox-4 expression.	ros	181-184	receptor interacting serine/threonine kinase 1	Homo sapiens	51-55
31300985-12	2019	In diabetes, Rac1 prenylation and its interactions with Vav2 contribute to Nox2-ROS-mitochondrial damage, and the pharmacological inhibitors to attenuate Rac1 interactions with its regulators could have the potential to halt/inhibit the development of diabetic retinopathy.	ros	80-83	vav guanine nucleotide exchange factor 2	Homo sapiens	56-60
31417181-9	2019	We demonstrated that the concomitant knockdown of four of these genes products, GPX2, GLRX, ALDH3A1, and PDK4, significantly increased ROS-dependent caspase activation, thus partially mimicking the consequences of NLUCAT1 inactivation in LUAD cells.	ros	135-138	glutathione peroxidase 2	Homo sapiens	80-84
31396684-1	2019	KEY MESSAGE: Co-expression of Na+/H+ antiporter NHX1 and DEAD-box RNA helicase eIF4A1 from Arabidopsis positively regulates drought stress tolerance by improving ROS scavenging capacity and maintaining membrane integrity in sweetpotato.	ros	162-165	Na+/H+ exchanger 1	Arabidopsis thaliana	48-52
31659154-6	2019	Furthermore, knockdown of miR-421 expression with an antisense morpholino oligonucleotide (AMO) increased ROS levels and treatment sensitivity to paclitaxel in vitro and in vivo, indicating that high miR-421 expression may at least partly account for paclitaxel tolerance in lung cancer patients.	ros	106-109	microRNA 421	Homo sapiens	26-33
31326389-3	2019	In HUVECs (human umbilical vein endothelial cells), overexpression of NEDD4 reduced Ang II-induced ROS level and cell apoptosis.	ros	99-102	NEDD4 E3 ubiquitin protein ligase	Homo sapiens	70-75
31163256-11	2019	Inhibition of CDK5 with myricetin or roscovitine, a CDK5 inhibitor attenuates thapsigargin induced p66Shc serine 36 phosphorylation and also reduced mitochondrial dysfunction by decreasing mitochondrial ROS and caspase-3 activation.	ros	203-206	cyclin dependent kinase 5	Homo sapiens	14-18
8238533-1	1993	We postulated that tumor necrosis factor-alpha (TNF) "primes" the lung for the development of pulmonary vasoconstriction and edema by inducing the release of polymorphonuclear leukocyte (PMN)-derived reactive oxidant species (ROS).	ros	226-229	tumor necrosis factor	Cavia porcellus	19-46
31253394-9	2019	In addition, depletion of HuR suppressed the generation of mitochondrial ROS and cytotoxicity in MPP+ treated cells.	ros	73-76	ELAV like RNA binding protein 1	Homo sapiens	26-29
31534504-8	2019	The loss of DJ-1 resulted in mitochondrial dysfunction and ROS accumulation, thus leading to CRC growth inhibition.	ros	59-62	Parkinsonism associated deglycase	Homo sapiens	12-16
8238533-1	1993	We postulated that tumor necrosis factor-alpha (TNF) "primes" the lung for the development of pulmonary vasoconstriction and edema by inducing the release of polymorphonuclear leukocyte (PMN)-derived reactive oxidant species (ROS).	ros	226-229	tumor necrosis factor	Cavia porcellus	48-51
31534504-10	2019	Conclusion: Our study demonstrates that DJ-1 loss-induced ROS accumulation plays a pivotal role in CPX-mediated CRC inhibition, providing a further understanding for CRC treatment via modulating compensatory protective autophagy.	ros	58-61	Parkinsonism associated deglycase	Homo sapiens	40-44
8238533-7	1993	The data suggest that ROS generated from PMN mediate the decrease in nitric oxide and altered pulmonary vasoreactivity induced by TNF.	ros	22-25	tumor necrosis factor	Cavia porcellus	130-133
31277230-5	2019	The CE-induced ROS increase together with AF-medicated inhibition of thioredoxin reductase cause a shift of Trx2 to an oxidized state, leading to degradation of MTCO2 and dysfunction of the electron transport chain.	ros	15-18	thioredoxin 2	Homo sapiens	108-112
31026688-10	2019	Furthermore, mitochondrial ROS levels in both RAW 264.7 cells and PMs were elevated by exposure to beta-CYP, and molecular docking showed that beta-CYP docked with mouse respiratory chain complex I by binding to the ND2, ND4, and ND5 subunits of the protein complex.	ros	27-30	NADH dehydrogenase 2, mitochondrial	Mus musculus	216-219
30821169-9	2019	Taken together, these results indicated that PCB126, PCB118, or PCB153 exposure promotes cervical cancer HeLa cell survival by PKM2-dependent upregulation of glycolysis, which is mediated by NADPH oxidase-induced ROS production.	ros	213-216	pyruvate kinase M1/2	Homo sapiens	127-131
2241957-3	1990	Other non-stromal osteoblastic cell lines, MC-3T3-E1, ROS 17/2.8 cells derived from mouse long bone explants, were also rich in NEP.	ros	54-57	membrane metallo endopeptidase	Mus musculus	128-131
31084929-7	2019	Furthermore, we found that superoxide anion levels were significantly increased in AngII-treated endothelial cells compared with controls and that the ROS scavenger N-acetyl-l-cysteine (NAC) significantly abolished CSE ubiquitination.	ros	151-154	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	215-218
31084929-8	2019	Taken together, our data suggested that AngII inhibited endogenous H2S generation through ubiquitination-mediated CSE degradation via the ROS pathway in vascular endothelial cells.	ros	138-141	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	114-117
33811613-10	2021	CMCS treatment considerably enhanced the expression of THOR and IGF2BP1 protein and cell viability but reduced ROS level and cell apoptosis.	ros	111-114	cerebral malaria susceptibility in CBA/N	Mus musculus	0-4
31194700-4	2019	Targeted alpha-synuclein overexpression within these neurons triggered an oxidative stress that became significantly more pronounced after exposure to the ROS-generating agent paraquat.	ros	155-158	synuclein alpha	Homo sapiens	9-24
31285773-9	2019	Mechanistically, vitamin C eradicated BRAF wild-type thyroid cancer cells through ROS-mediated decrease in the activity of EGF/EGFR-MAPK/ERK signaling and an increase in AKT ubiquitination and degradation.	ros	82-85	Braf transforming gene	Mus musculus	38-42
31285773-9	2019	Mechanistically, vitamin C eradicated BRAF wild-type thyroid cancer cells through ROS-mediated decrease in the activity of EGF/EGFR-MAPK/ERK signaling and an increase in AKT ubiquitination and degradation.	ros	82-85	epidermal growth factor	Mus musculus	123-126
31285773-9	2019	Mechanistically, vitamin C eradicated BRAF wild-type thyroid cancer cells through ROS-mediated decrease in the activity of EGF/EGFR-MAPK/ERK signaling and an increase in AKT ubiquitination and degradation.	ros	82-85	epidermal growth factor receptor	Mus musculus	127-131
33811613-13	2021	CONCLUSION: CMCS enhanced the cell viability and reduced the cell apoptosis and ROS level and protected RGCs from oxidative stress via lncRNATHOR/IGF2BP1 pathway, potentially suggesting a new therapeutic strategy for the treatment of glaucoma.	ros	80-83	cerebral malaria susceptibility in CBA/N	Mus musculus	12-16
31285773-10	2019	On the other hand, vitamin C exerted its antitumor activity in BRAF mutant thyroid cancer cells by inhibiting the activity of ATP-dependent MAPK/ERK signaling and inducing proteasome degradation of AKT via the ROS-dependent pathway.	ros	210-213	Braf transforming gene	Mus musculus	63-67
31060923-8	2019	There were large amounts of pro-apoptotic cytochrome c (Cytc) and cleaved caspase-9/3 proteins detected using western blot analysis after 30 days of spermatozoa storage at 4  C. These findings indicate ROS generation induces mitochondria damage after 20 days of storage at 4  C, which can induce spermatozoa apoptotic-like changes during storage of soft-shelled turtle spermatozoa.	ros	202-205	caspase-9	Pelodiscus sinensis	74-83
33819194-8	2021	In addition, PRDX2 knockdown led to increased ROS production in CD133+CD44+ CCSCs, sensitizing CCSCs to oxidative stress and chemotherapy.	ros	46-49	prominin 1	Homo sapiens	64-69
33791071-0	2021	Pegylated Recombinant Human Arginase 1 Induces Autophagy and Apoptosis via the ROS-Activated AKT/mTOR Pathway in Bladder Cancer Cells.	ros	79-82	arginase 1	Homo sapiens	28-38
34474361-3	2022	Results show that repeated 4-ABP exposure promoted cellular proliferation and migration via the involvement of ROS in Ras/MEK/ERK pathway in vitro.	ros	111-114	amine oxidase copper containing 1	Homo sapiens	29-32
30923989-0	2019	Correction to: Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of beta-catenin pathway.	ros	172-175	catenin beta 1	Homo sapiens	199-211
34896222-0	2022	AMPK/PPAR-gamma/NF-kappaB axis participates in ROS-mediated apoptosis and autophagy caused by cadmium in pig liver.	ros	47-50	protein kinase AMP-activated catalytic subunit alpha 1	Sus scrofa	0-4
31012036-8	2019	RESULTS: We showed that PC2 knockdown promoted cell proliferation, ROS productions and ERK phosphorylation, compared with negative control.	ros	67-70	polycystin 2, transient receptor potential cation channel	Mus musculus	24-27
31012036-10	2019	Inhibition of ROCE and SOCE by specific inhibitors partially reversed the enhanced cell proliferation, ROS productions and ERK phosphorylation induced by PC2 knockdown.	ros	103-106	polycystin 2, transient receptor potential cation channel	Mus musculus	154-157
31012036-12	2019	Furthermore, we showed that mitochondrial located TRPC3 was upregulated and modulating mitochondrial calcium uptake, thus promoting the ROS productions in the presence of PC2 knockdown.	ros	136-139	polycystin 2, transient receptor potential cation channel	Mus musculus	171-174
31054074-4	2019	DJ-1 increases the expression of two mitochondrial uncoupling proteins (UCP 4 and UCP5), that decrease mitochondrial membrane potential and leads to the suppression of ROS production, optimizes of a number of mitochondrial functions, and is regarded as protection for the neuronal cell survival.	ros	168-171	Parkinsonism associated deglycase	Homo sapiens	0-4
34890707-8	2022	ROS and ROS/MAPK (Erk1/2, p38) functioned as the upstream signaling molecules in the activation of NF-kappaB and AP-1, respectively.	ros	0-3	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-117
2975508-5	1988	The addition of 9,13-dicis-retinal to the ROS suspension containing opsin produced 9-cis-rhodopsin in 97% yield.	ros	42-45	rhodopsin	Bos taurus	89-98
34890707-8	2022	ROS and ROS/MAPK (Erk1/2, p38) functioned as the upstream signaling molecules in the activation of NF-kappaB and AP-1, respectively.	ros	8-11	JunD proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	113-117
34808100-20	2022	Our results support the concept that EVO induces ROS-dependent cytotoxicity via TRPV1/Ca2+ Pathway.	ros	49-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	80-85
31121492-9	2019	Additionally, LPS stimulation also promoted the production of intracellular reactive oxygen (ROS), which further induced the NLRP3 translocation to the cytoplasm from the nucleus.	ros	93-96	NLR family, pyrin domain containing 3	Mus musculus	125-130
34965422-3	2021	USP19 antagonizes RNF1-mediated ME1 degradation by deubiquitination, which in turn promotes lipid metabolism and NADPH production and suppresses ROS.	ros	145-148	ring finger protein 1	Homo sapiens	18-22
34908105-0	2021	Correction: Alamandine attenuates hepatic fibrosis by regulating autophagy induced by NOX4-dependent ROS.	ros	101-104	NADPH oxidase 4	Homo sapiens	86-90
31138329-9	2019	CONCLUSIONS: Our study highlights the critical role of ROS-mediating CaMKII/Drp1 signaling in the regulation of mitochondrial fission and apoptosis induced by combination of CQ/IH.	ros	55-58	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	69-75
31038133-7	2019	In addition, brosimone I was found to increase ROS generation and the inhibition of ROS formation by NAC, a ROS inhibitor, attenuated brosimone I-induced cell death, cytosolic Ca2+ increase, and ER stress markers.	ros	84-87	synuclein alpha	Homo sapiens	101-104
34884534-2	2021	Clinical studies and research in rodent models demonstrated that failure of repair mechanisms to cope with increased ROS and inflammation in the lung leads to COPD.	ros	117-120	COPD	Homo sapiens	159-163
31038133-7	2019	In addition, brosimone I was found to increase ROS generation and the inhibition of ROS formation by NAC, a ROS inhibitor, attenuated brosimone I-induced cell death, cytosolic Ca2+ increase, and ER stress markers.	ros	84-87	synuclein alpha	Homo sapiens	101-104
34599937-11	2021	H/R-induced production of mitochondrial ROS in HK-2 cells was due to MAO-A-catalyzed 5-HT degradation, and 5-HT2AR was involved by mediating the expression of 5-HT synthases and MAO-A.	ros	40-43	monoamine oxidase A	Rattus norvegicus	69-74
30857947-0	2019	Blockage of ROS and MAPKs-mediated inflammation via restoring SIRT1 by a new compound LF10 prevents type 1 diabetic cardiomyopathy.	ros	12-15	sirtuin 1	Mus musculus	62-67
34599937-11	2021	H/R-induced production of mitochondrial ROS in HK-2 cells was due to MAO-A-catalyzed 5-HT degradation, and 5-HT2AR was involved by mediating the expression of 5-HT synthases and MAO-A.	ros	40-43	monoamine oxidase A	Rattus norvegicus	178-183
30995715-2	2019	LKB1 has an essential role in the control of cellular redox homeostasis by regulating ROS production and detoxification.	ros	86-89	serine/threonine kinase 11	Homo sapiens	0-4
34509754-8	2021	The productions of ROS, NO, and GBP2 were significantly reduced in TLR2-/- and TLR3-/- mouse macrophages.	ros	19-22	toll-like receptor 2	Mus musculus	67-71
30673591-4	2019	Further mechanism of action studies indicate that Ir2-initiated apoptosis occurs through ROS-mediated cross-talk between mitochondria and lysosomes.	ros	89-92	immune response 2	Mus musculus	50-53
34468815-8	2021	Nox4 was significantly upregulated only in CMD-exposed ABCs and NOX4 activation of PI3K/AKT can lead to increased ROS levels in human cancer cells.	ros	114-117	NADPH oxidase 4	Homo sapiens	0-4
30965686-10	2019	By inhibiting ALDH1A1, CM37 augmented intracellular ROS accumulation, which in turn led to increased DNA damage and reduced OC cell viability.	ros	52-55	aldehyde dehydrogenase 1 family member A1	Homo sapiens	14-21
34468815-8	2021	Nox4 was significantly upregulated only in CMD-exposed ABCs and NOX4 activation of PI3K/AKT can lead to increased ROS levels in human cancer cells.	ros	114-117	NADPH oxidase 4	Homo sapiens	64-68
30826469-4	2019	Moreover, Nrf2 translocation appeared both in GD 12.5 d and GD 18.5 d. In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage.	ros	98-101	heme oxygenase 1	Homo sapiens	206-210
34289205-0	2021	Alantolactone is a natural product that potently inhibits YAP1/TAZ via promotion of ROS accumulation.	ros	84-87	Yes1 associated transcriptional regulator	Homo sapiens	58-62
30597234-9	2019	MiR-126 also attenuates the ROS elevation and mitochondrial membrane potential through JC-1 detection.	ros	28-31	microRNA 126b	Rattus norvegicus	0-7
34289205-5	2021	We also tested 16 other structural derivatives of ALT and found that natural ALT was the most efficient at increasing ROS-induced LATS kinase activities and thus YAP1/TAZ phosphorylation.	ros	118-121	yes-associated protein 1	Mus musculus	162-166
34289205-7	2021	Our data show for the first time that ALT can be used to target the ROS-YAP pathway driving tumor cell growth and so may be a potent anti-cancer drug.	ros	68-71	Yes1 associated transcriptional regulator	Homo sapiens	72-75
34416243-9	2021	Furthermore, overexpression of A20 enhanced cell viability, reduced apoptosis, and inhibited ROS generation and inflammatory factor secretion.	ros	93-96	tumor necrosis factor, alpha-induced protein 3	Mus musculus	31-34
31001372-5	2019	LPS induced significant elevation of TNF-alpha, IL-6, MDA, and ROS and reduction of GSH and SOD in the mouse brains and primary microglia, which were reversed by MFG-E8 pretreatment.	ros	63-66	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	162-168
30475154-5	2019	Following LPS-induced autophagy, GFP-LC3 puncta were increased, and this was suppressed by inhibiting mitochondrial fission and mitochondrial ROS.	ros	142-145	interferon regulatory factor 6	Homo sapiens	10-13
30475154-7	2019	Taken together, these results indicate that ROS induction due to increased LPS-stimulated mitochondrial fission triggers p62 mediated autophagy in microglial cells.	ros	44-47	interferon regulatory factor 6	Homo sapiens	75-78
34218417-5	2021	We further show that OGD/R-induced downregulation of SETD3 leads to the decrease of cellular ATP level, the reduction of mitochondrial electric potential and the increase of ROS production, thereby promoting mitochondrial dysfunction.	ros	174-177	SET domain containing 3, actin histidine methyltransferase	Rattus norvegicus	53-58
30736789-14	2019	CONCLUSIONS: These results indicate that STL or STB may induce GSK3beta-dependent cyclin D1 degradation, and increase HO-1 expression through activating Nrf2 via ROS-dependent p38 activation, which resulted in the decrease of the viability in SW480 cells.	ros	162-165	heme oxygenase 1	Homo sapiens	118-122
30472366-8	2019	In a mechanistic study, addition of MT1 or RORalpha antagonist increased ROS and MDA concentrations, but decreased T-AOC, GPx, CAT and T-SOD concentrations (P &lt; 0.05), whereas there were no significant difference between the melatonin and MT2 antagonist treatment groups for T-AOC, GPx, CAT and T-SOD concentrations.	ros	73-76	MT-1	Ovis aries	36-39
30557609-5	2019	Mechanistically, DHA induced autophagy by regulating the activity of AMPK/mTOR/p70S6k signaling pathway, which accelerated the degradation of ferritin, increased the labile iron pool, promoted the accumulation of cellular ROS and eventually led to ferroptotic cell death.	ros	222-225	ribosomal protein S6 kinase B1	Homo sapiens	79-85
34343908-7	2021	Further, enhanced cell retention of IR-780 is shown to promote severe inhibition of SDHA in myofibroblasts, which may contribute to excessive ROS generation and selectively induces myofibroblasts to apoptosis, and then therapeutically improves established lung fibrosis in vivo.	ros	142-145	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	84-88
30766473-5	2019	Due to their high capacity to diffuse across membranes, ROS/RNS can reach neurons and modify their activity.	ros	56-59	FAM20C golgi associated secretory pathway kinase	Homo sapiens	60-63
30700698-6	2019	Moreover, ROS scavengers demonstrated that the observed effect of cyclinB1 silencing on AMPK phosphorylation was ROS dependent.	ros	113-116	cyclin B1	Homo sapiens	66-74
30805082-2	2019	Given that ROS-induced NLRP3 activation plays a central role in the pathogenesis of type 2 diabetic kidney injury, we evaluate whether VEGFR2 upregulation induces type 2 diabetic kidney injury via ROS-mediated NLRP3 activation and further explore the underlying mechanism.	ros	11-14	NLR family, pyrin domain containing 3	Mus musculus	23-28
34310992-5	2021	The upregulation of NOX4 expression promoted ROS-mediated p38 MAPK phosphorylation, leading to protein phosphatase 2A (PP2A)-regulated tristetraprolin (TTP) degradation.	ros	45-48	NADPH oxidase 4	Homo sapiens	20-24
30805082-2	2019	Given that ROS-induced NLRP3 activation plays a central role in the pathogenesis of type 2 diabetic kidney injury, we evaluate whether VEGFR2 upregulation induces type 2 diabetic kidney injury via ROS-mediated NLRP3 activation and further explore the underlying mechanism.	ros	197-200	NLR family, pyrin domain containing 3	Mus musculus	210-215
30805082-5	2019	Collectively, the VEGFR2/ROS/NLRP3 signal is a critical therapeutic strategy for the kidney injury of HFD-treated mice.	ros	25-28	NLR family, pyrin domain containing 3	Mus musculus	29-34
30834779-9	2019	Inhibition of p38 activation and ROS elimination attenuated HO-1 expression by ST-L and ST-B, and ROS elimination inhibited p38 activation induced by ST-L and ST-B.	ros	33-36	stubby	Mus musculus	88-92
30834779-9	2019	Inhibition of p38 activation and ROS elimination attenuated HO-1 expression by ST-L and ST-B, and ROS elimination inhibited p38 activation induced by ST-L and ST-B.	ros	98-101	stubby	Mus musculus	159-163
30834779-10	2019	ST-L and ST-B dramatically induced nuclear accumulation of Nrf2, but this was significantly reversed by the inhibition of p38 activation and ROS elimination.	ros	141-144	stubby	Mus musculus	9-13
30834779-11	2019	Collectively, our results suggest that ST-L and ST-B exerts potential anti-inflammatory activity by suppressing NF- kappa B and MAPK signaling activation, and activating HO-1 expression through the nuclear accumulation of Nrf2 via ROS-dependent p38 activation.	ros	231-234	stubby	Mus musculus	48-52
30599913-14	2019	The induction of apoptosis in OSCC cells by LCH was evident in the increased production of ROS, loss of mitochondrial membrane potential, release of cyto c, variation of apoptotic proteins and activation of caspase cascade.	ros	91-94	LCH	Homo sapiens	44-47
30384260-4	2019	At the molecular level, Mst1 upregulation exacerbated mitochondrial damage, as evidenced by reduced mitochondrial potential, increased ROS generation, more cyt-c liberation from mitochondria into the cytoplasm, and an activated mitochondrial apoptotic pathway.	ros	135-138	macrophage stimulating 1	Homo sapiens	24-28
30359575-13	2018	In-vitro experiments demonstrated that inhibition of PARP-1 in cardiomyocytes exposed to high levels of glucose and AT led to a significant reduction in ROS (P &lt; 0.01), which was abolished in the presence of the SIRT1 inhibitor together with increased protein expression of SIRT1 and PGC-1alpha.	ros	153-156	sirtuin 1	Mus musculus	215-220
30029111-10	2018	Simultaneously, ROS induced persistent DNA-damage (Comet-assay) that stimulated G2/M arrest for p53-mediated damage-repair, aided by checkpoint-promoter (Chk1) activation and mitotic-inducers (i.e. Cdc-25, Cdk1, cyclinB1) inhibition.	ros	16-19	cell division cycle 25C	Homo sapiens	198-204
30029111-10	2018	Simultaneously, ROS induced persistent DNA-damage (Comet-assay) that stimulated G2/M arrest for p53-mediated damage-repair, aided by checkpoint-promoter (Chk1) activation and mitotic-inducers (i.e. Cdc-25, Cdk1, cyclinB1) inhibition.	ros	16-19	cyclin dependent kinase 1	Homo sapiens	206-210
30029111-10	2018	Simultaneously, ROS induced persistent DNA-damage (Comet-assay) that stimulated G2/M arrest for p53-mediated damage-repair, aided by checkpoint-promoter (Chk1) activation and mitotic-inducers (i.e. Cdc-25, Cdk1, cyclinB1) inhibition.	ros	16-19	cyclin B1	Homo sapiens	212-220
30268520-7	2018	Moreover, Bay 60-7550 decreased corticosterone-induced gp91phox expression, which is the source of ROS.	ros	99-102	paired Ig-like receptor B	Mus musculus	55-59
30557449-7	2018	Whereas, in myotubes in the presence of palmitate, a ~50% knockdown of Seps1 was associated with a trend toward a marginal (3-5%) decrease in viability (P = 0.05), decreased cellular ROS levels, and a reduced mRNA transcript abundance of the cellular stress marker thioredoxin inhibitory binding protein (Txnip).	ros	183-186	selenoprotein S	Homo sapiens	71-76
30459314-10	2018	Our findings indicate that expression and activation of p66Shc renders CNS cells more sensitive to Abeta toxicity by promoting mitochondrial OXPHOS and ROS production while repressing aerobic glycolysis.	ros	152-155	amyloid beta (A4) precursor protein	Mus musculus	99-104
30092543-5	2018	PM2.5 could be internalized into cells through multiple endocytosis processes, such as phagocytosis and pinocytosis (macropinocytosis, clathrin- and caveolin-mediated endocytosis), and activate NLRP3 inflammasome through cathepsin B release, ROS production, and potassium efflux.	ros	242-245	NLR family, pyrin domain containing 3	Mus musculus	194-199
30122554-5	2018	Decreased ROS production in KO-AOX versus KO mice led to impaired AMPK/PGC-1alpha signaling and PAX7/MYOD-dependent muscle regeneration, blunting compensatory responses.	ros	10-13	myogenic differentiation 1	Mus musculus	101-105
30345755-6	2018	CAM can disaggregate the beta-sheet-rich fibrils and metal-induced or self-aggregated Abeta aggregates, and it further inhibits the production of ROS; as a result, it can protect the neurons from synaptic toxicity induced by Zn2+- or Cu2+-Abeta aggregates or Abeta self-aggregation.	ros	146-149	amyloid beta (A4) precursor protein	Mus musculus	239-244
30345755-6	2018	CAM can disaggregate the beta-sheet-rich fibrils and metal-induced or self-aggregated Abeta aggregates, and it further inhibits the production of ROS; as a result, it can protect the neurons from synaptic toxicity induced by Zn2+- or Cu2+-Abeta aggregates or Abeta self-aggregation.	ros	146-149	amyloid beta (A4) precursor protein	Mus musculus	239-244
30255178-4	2018	Herein, we report the design and synthesis of a ROS-triggered prodrug nanoplatform fabricated with oxidation-responsive cabazitaxel (CTX) prodrugs for synergistic chemo-photodynamic therapy, thioether-/selenoether-linked conjugates of CTX and oleic acid (OA).	ros	48-51	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	133-136
30255178-4	2018	Herein, we report the design and synthesis of a ROS-triggered prodrug nanoplatform fabricated with oxidation-responsive cabazitaxel (CTX) prodrugs for synergistic chemo-photodynamic therapy, thioether-/selenoether-linked conjugates of CTX and oleic acid (OA).	ros	48-51	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	235-238
30255178-6	2018	The dual-source ROS-responsive prodrug nanosystems selectively and rapidly release CTX not only in response to endogenous ROS overproduced in tumor cells, but also to exogenous PPa-generated ROS under laser irradiation.	ros	16-19	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	83-86
30255178-6	2018	The dual-source ROS-responsive prodrug nanosystems selectively and rapidly release CTX not only in response to endogenous ROS overproduced in tumor cells, but also to exogenous PPa-generated ROS under laser irradiation.	ros	122-125	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	83-86
30255178-6	2018	The dual-source ROS-responsive prodrug nanosystems selectively and rapidly release CTX not only in response to endogenous ROS overproduced in tumor cells, but also to exogenous PPa-generated ROS under laser irradiation.	ros	122-125	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	83-86
30242250-0	2018	Respiratory Syncytial Virus induces the classical ROS-dependent NETosis through PAD-4 and necroptosis pathways activation.	ros	50-53	peptidyl arginine deiminase 4	Homo sapiens	80-85
30009776-10	2018	Moreover, Bax antagonist Bax inhibitor peptide (BIP) V5 ameliorated TP-induced apoptosis through suppressing membrane depolarization and ROS accumulation.	ros	137-140	BCL2 associated X, apoptosis regulator	Rattus norvegicus	10-13
30009776-10	2018	Moreover, Bax antagonist Bax inhibitor peptide (BIP) V5 ameliorated TP-induced apoptosis through suppressing membrane depolarization and ROS accumulation.	ros	137-140	BCL2 associated X, apoptosis regulator	Rattus norvegicus	25-28
29929000-0	2018	Telmisartan generates ROS-dependent upregulation of death receptor 5 to sensitize TRAIL in lung cancer via inhibition of autophagy flux.	ros	22-25	TNF receptor superfamily member 10b	Homo sapiens	52-68
29929000-6	2018	The molecular mechanism includes the blocking of AMPK phosphorylation causes inhibition of autophagy flux by telmisartan resulting in ROS generation leading to death receptor (DR5) upregulation and subsequent activation of the caspase cascade by TRAIL treatment.	ros	134-137	TNF receptor superfamily member 10b	Homo sapiens	176-179
29929000-7	2018	Furthermore, using chloroquine and siATG5 significantly enhances ROS production and application of the ROS scavenger N-acetyl-cysteine (NAC) rescues the cells undergoing apoptosis by abrogating the expression of DR5 and finally the caspase cascade.	ros	103-106	TNF receptor superfamily member 10b	Homo sapiens	212-215
30210350-5	2018	LPS-stimulated RAW 264.7 cells were used to verify the regulating effects of T11 on oxidative stress (ROS and Nrf2 signaling pathway) and inflammatory cytokines production (TNF-alpha, IL-6 and IL-1beta).	ros	102-105	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	77-80
30210350-8	2018	Firstly, the results showed that T11 can not only effectively decrease the productions of inflammatory cytokines (TNF-alpha, IL-6 and IL-1beta), ROS and NO in LPS-stimulated RAW 264.7 cells, but also further significantly increase the activity of Nrf2 in HEK-293T cells.	ros	145-148	histocompatibility 2, T region locus 11, pseudogene	Mus musculus	33-36
30154812-8	2018	This study identifies a new layer of complexity between auxin, Pi nutrient availability and RSL2/RSL4 transcription factors all acting on ROS homeostasis and growth at the root hair level.	ros	138-141	root hair defective 6-like 4	Arabidopsis thaliana	97-101
6305022-2	1982	Intact bovine ROS showed a total nucleotide concentration of 1.0 mM, ATP and GTP being the major components (0.1-0.2 mol per mol of rhodopsin).	ros	14-17	rhodopsin	Bos taurus	132-141
25681-3	1978	After illumination of ROS and digitonin, triton X-100 and CTAB-solubilized rhodopsin, and increase was observed in the number of modified SH-groups.	ros	22-25	rhodopsin	Bos taurus	75-84
33848529-6	2021	Both rAP2M1A and AP2M1A354-382 were shown to execute antibacterial activity by a combined action of destabilization/destruction of bacterial cell wall through interaction with LPS and LTA, disturbance of the usually polarized membrane through depolarization, and apoptosis/necrosis through intracellular ROS production.	ros	304-307	transcription factor AP-2 alpha	Danio rerio	6-9
33930848-0	2021	An upward 9.4 T static magnetic field inhibits DNA synthesis and increases ROS-P53 to suppress lung cancer growth.	ros	75-78	transformation related protein 53, pseudogene	Mus musculus	79-82
34056995-7	2021	Therefore, this work demonstrates for the first time that L-carnosine may be used as adjuvant therapy for the preservation of visual integrity in patients with DED.HighlightsIL-1alpha induced dry eye disease through its oxidative stress, proinflammatory, apoptotic and profibrotic effects on the lacrimal glands of rabbit.L-carnosine has antioxidant, anti-inflammatory, antiapoptotic and antifibrotic effects.L-carnosine mitigated IL-1alpha induced dry eye disease via elevating the levels of FasL, IFN-gamma, TNF-alpha, TGFbeta1 and MDA as well as reducing the levels of antioxidants (GPx, SOD, and catalase) and ROS in the lacrimal glands of rabbit.L-carnosine could be used as a novel adjuvant therapy for the treatment of dry eye disease.	ros	614-617	interleukin 1 alpha	Homo sapiens	174-183
34051372-2	2021	This happens, at least in part, because TLR4 modulates the enzyme NADPH oxidase, a primary source of ROS in vascular structures.	ros	101-104	toll like receptor 4	Homo sapiens	40-44
34051372-5	2021	Given the importance of the interaction between TLR4 and NADPH oxidase to the disrupted diabetic vascular system, we put forward the hypothesis that TLR4-mediated NADPH oxidase-derived ROS might be a critical mechanism to help explain why this disparity appears in diabetic patients, but unfortunately, conclusive experimental evidence still lacks in the literature.	ros	185-188	toll like receptor 4	Homo sapiens	48-52
34051372-5	2021	Given the importance of the interaction between TLR4 and NADPH oxidase to the disrupted diabetic vascular system, we put forward the hypothesis that TLR4-mediated NADPH oxidase-derived ROS might be a critical mechanism to help explain why this disparity appears in diabetic patients, but unfortunately, conclusive experimental evidence still lacks in the literature.	ros	185-188	toll like receptor 4	Homo sapiens	149-153
34021870-0	2021	Correction to: Activation of ATM kinase by ROS generated during ionophore-induced mitophagy in human T and B cell malignancies.	ros	43-46	ATM serine/threonine kinase	Homo sapiens	29-32
34001853-0	2021	SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis.	ros	67-70	AXL receptor tyrosine kinase	Homo sapiens	108-111
34001853-7	2021	Functionally, ROS accumulation in CLL cells activated the AXL survival axis while upregulated SIRT3, suggesting that CLL cells rapidly remove highly reactive O2- to avoid its cytotoxic effect but maintain increased H2O2-level to promote cell survival.	ros	14-17	AXL receptor tyrosine kinase	Homo sapiens	58-61
34004336-0	2021	Tumorigenic Effect Mediated by ROS/Eicosanoids and their regulation on TP53 expression in a Murine Mammary Gland Adenocarcinoma.	ros	31-34	transformation related protein 53	Mus musculus	71-75
34045966-4	2021	Meanwhile, CD13 can activate NRF1 and up-regulate ROS scavenging genes transcription, such as SOD1, GPX1, GPX2 and GPX3, leading to down-regulation of intracellular ROS level and reducing the sensitivity of cells to chemotherapy agent.	ros	50-53	glutathione peroxidase 2	Homo sapiens	106-110
33791850-0	2021	Correction to: Dexmedetomidine suppresses bupivacaine-induced parthanatos in human SH-SY5Y cells via the miR-7-5p/PARP1 axis-mediated ROS.	ros	134-137	microRNA 7-1	Homo sapiens	105-113
33901009-5	2021	Although histone deacetylase inhibitor could not enhance cell death in HDACi-R but upregulation of miR-107 decreased cell viability both in parental cells and resistance cells, decreased the expression of cofilin-1, enhanced ROS-induced cell apoptosis, and dose-dependently sensitized HDACi-R to HDACi.	ros	225-228	microRNA 107	Mus musculus	99-106
33901009-7	2021	Our findings demonstrated that miR-107 downregulation leads to hepatocellular carcinoma cell resistance in HDACi via a cofilin-1-dependent molecular mechanism and ROS accumulation.	ros	163-166	microRNA 107	Mus musculus	31-38
33981237-17	2021	In the in vitro hepatocyte injury model, the SIRT1 inhibitor significantly increased intracellular ROS levels and reversed the effect of DEX on autophagy flux.	ros	99-102	sirtuin 1	Mus musculus	45-50
33937399-0	2021	Knockdown of Gastrin Promotes Apoptosis of Gastric Cancer Cells by Decreasing ROS Generation.	ros	78-81	gastrin	Homo sapiens	13-20
33937399-13	2021	The apoptosis rate of the gastrin knockdown cancer cell was significantly increased; meanwhile, gastrin knockdown leads to increase of membrane potential and decrease of intracellular ROS production.	ros	184-187	gastrin	Homo sapiens	26-33
33937399-13	2021	The apoptosis rate of the gastrin knockdown cancer cell was significantly increased; meanwhile, gastrin knockdown leads to increase of membrane potential and decrease of intracellular ROS production.	ros	184-187	gastrin	Homo sapiens	96-103
33937399-16	2021	Gastrin promotes the production of ROS from mitochondria, activates NF-kappaB, and inhibits apoptosis via modulating the expression level of Bcl-2 and Bax.	ros	35-38	gastrin	Homo sapiens	0-7
30025345-4	2018	These results preliminarily show that the important role of ROS mediated activation of ASK1/MAPK signaling pathways by this title compound.	ros	60-63	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	87-91
29157919-0	2018	PML nuclear bodies, membrane-less domains acting as ROS sensors?	ros	52-55	PML nuclear body scaffold	Homo sapiens	0-3
29157919-3	2018	Here we summarize recent in vitro and in vivo findings on the link between PML NBs and ROS, in particular PML contributions to oxidative stress response.	ros	87-90	PML nuclear body scaffold	Homo sapiens	75-78
29157919-3	2018	Here we summarize recent in vitro and in vivo findings on the link between PML NBs and ROS, in particular PML contributions to oxidative stress response.	ros	87-90	PML nuclear body scaffold	Homo sapiens	106-109
34310992-5	2021	The upregulation of NOX4 expression promoted ROS-mediated p38 MAPK phosphorylation, leading to protein phosphatase 2A (PP2A)-regulated tristetraprolin (TTP) degradation.	ros	45-48	ZFP36 ring finger protein	Homo sapiens	135-150
33837631-5	2021	All these events are neutralized by NAC, an anti-ROS, suggesting that CCCP-induced mitochondrial dysfunction promotes oxidative stress.	ros	49-52	synuclein alpha	Homo sapiens	36-39
34681066-0	2021	Hydroxychloroquine Attenuates Acute Inflammation (LPS)-Induced Apoptosis via Inhibiting TRPV1 Channel/ROS Signaling Pathways in Human Monocytes.	ros	102-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
33837217-3	2021	MOCCI, a paralog of the NDUFA4 subunit of cytochrome C oxidase (Complex IV), replaces NDUFA4 in Complex IV during inflammation to lower mitochondrial membrane potential and reduce ROS production, leading to cyto-protection and dampened immune response.	ros	180-183	NDUFA4 mitochondrial complex associated	Homo sapiens	24-30
29999509-5	2018	Our first "Pinkment" was shown to detect biologically relevant concentrations of ONOO- and have an excellent selectivity against other ROS/RNS.	ros	135-138	FAM20C golgi associated secretory pathway kinase	Homo sapiens	139-142
29999509-6	2018	Pinkment-OH was developed to provide a core unit which could be easily functionalised to produce a range of "AND" based fluorescence probes for the detection of ROS/RNS and a second analyte.	ros	161-164	FAM20C golgi associated secretory pathway kinase	Homo sapiens	165-168
34572022-7	2021	MR-39 was the only FPR2 ligand that attenuated LPS-evoked changes in the mitochondrial membrane potential and diminished the ROS and NO release.	ros	125-128	formyl peptide receptor 2	Rattus norvegicus	19-23
30036983-7	2018	DAF-16 is essential for the reduction of thermally induced ROS accumulation, while the resistance against paraquat-induced oxidative stress is dependent on SIR-2.1.	ros	59-62	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	0-6
29653364-8	2018	Overexpressed miR-20a reduced ROS generation under Ox-LDL treatment, and this effect was restored by forced expression of TLR4.	ros	30-33	toll like receptor 4	Homo sapiens	122-126
33898397-8	2021	The mechanism experiments showed that the antitumor activity of ORI-NPs against breast cancer might be through ROS related Nrf2/HO-1 signaling pathway.	ros	111-114	heme oxygenase 1	Homo sapiens	128-132
33824458-0	2022	C0818, a novel curcumin derivative, induces ROS-dependent cytotoxicity in human hepatocellular carcinoma cells in vitro via disruption of Hsp90 function.	ros	44-47	heat shock protein 90 alpha family class A member 1	Homo sapiens	138-143
34287039-7	2021	These findings indicate that PCV2-induced activation of the PERK-ERO1alpha axis would lead to enhanced generation of ROS sufficient to decrease HMGB1 retention in the nuclei, thus derepressing viral DNA from HMGB1 sequestration.	ros	117-120	high mobility group box 1	Homo sapiens	144-149
29545399-4	2018	The mechanisms of drug-induced downregulation of Sp TFs and pro-oncogenic Sp-regulated genes are complex and include ROS-dependent epigenetic pathways that initially decrease expression of the oncogene cMyc.	ros	117-120	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	202-206
34287039-7	2021	These findings indicate that PCV2-induced activation of the PERK-ERO1alpha axis would lead to enhanced generation of ROS sufficient to decrease HMGB1 retention in the nuclei, thus derepressing viral DNA from HMGB1 sequestration.	ros	117-120	high mobility group box 1	Homo sapiens	208-213
34287039-11	2021	Collectively, this study offers novel insight into the mechanism of enhanced viral replication in which PCV2 manipulates ER to perturb its redox homeostasis via the PERK-ERO1alpha axis and the ER-sourced ROS from oxidative folding is sufficient to reduce HMGB1 retention in the nuclei, hence the release of HMGB1-bound viral DNA for replication.	ros	204-207	high mobility group box 1	Homo sapiens	255-260
33523262-6	2021	For the majority of experiments, a concentration of 2.5 microM GP was used resulting in a ROS-independent but caspase-dependent cell death of A375 melanoma cells.	ros	90-93	ring finger protein 130	Homo sapiens	63-65
33523262-10	2021	Taken together, GP induced a ROS-independent intrinsic apoptosis leading to the conclusion that within a specific concentration range, GP may work as effective anticancer drug without harmful side effects.	ros	29-32	ring finger protein 130	Homo sapiens	16-18
34287039-11	2021	Collectively, this study offers novel insight into the mechanism of enhanced viral replication in which PCV2 manipulates ER to perturb its redox homeostasis via the PERK-ERO1alpha axis and the ER-sourced ROS from oxidative folding is sufficient to reduce HMGB1 retention in the nuclei, hence the release of HMGB1-bound viral DNA for replication.	ros	204-207	high mobility group box 1	Homo sapiens	307-312
33523262-10	2021	Taken together, GP induced a ROS-independent intrinsic apoptosis leading to the conclusion that within a specific concentration range, GP may work as effective anticancer drug without harmful side effects.	ros	29-32	ring finger protein 130	Homo sapiens	135-137
34287039-12	2021	IMPORTANCE Considering the fact that clinical PCVAD mostly results from activation of latent PCV2 infection by confounding factors such as co-infection or environmental stresses, we propose that such confounding factors might impose oxidative stress to the animals where PCV2 in infected cells might utilize the elevated ROS to promote HMGB1 migration out of nuclei in favor of its replication.	ros	321-324	high mobility group box 1	Homo sapiens	336-341
34102574-9	2021	Inhibition of DIC and OGC aggravated ferroptosis and increased mitochondrial ROS, membrane depolarization, and GSH depletion.	ros	77-80	solute carrier family 25 member 11	Homo sapiens	22-25
33651205-1	2022	KEY MESSAGE: StCDPK2 is an early player in the salt stress response in potato plants; its overexpression promoted ROS scavenging, chlorophyll stability, and the induction of stress-responsive genes conferring tolerance to salinity.	ros	114-117	calcium-dependent protein kinase 2	Solanum tuberosum	13-20
33421718-13	2021	In addition, BaP increased mitochondrial ROS production, and Mito-TEMP, a mitochondrial ROS inhibitor, inhibited BaP-induced MUC5AC expression and ERK activation.	ros	41-44	bap	None	13-16
34461809-5	2021	Overexpression of MALAT1 reduced the levels of TNF-alpha, IL-6, IL-1beta, ROS and MDA and increased the activities of SOD and CAT in OGD/R-injured PC12 cells.	ros	74-77	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	18-24
33394221-6	2021	PLD also mitigated the oxidative stress in Abeta-induced BV-2 cells, as evidenced by deceased production of ROS and MDA, and increased SOD activity.	ros	108-111	amyloid beta (A4) precursor protein	Mus musculus	43-48
34439368-4	2021	OLR1 is a metabolic gene that encodes for the Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), implicated in inflammation, atherosclerosis, ROS, and metabolic disorder-associated carcinogenesis.	ros	156-159	oxidized low density lipoprotein receptor 1	Homo sapiens	0-4
33515706-5	2021	Moreover, DPDS suppressed NLRP3 inflammasome activation by decreasing protein nitration via reduction in NO and ROS levels, whose low levels are related to NF-kappaB inhibition responsible for iNOS and NOX2 down-regulations, respectively.	ros	112-115	NLR family, pyrin domain containing 3	Mus musculus	26-31
33620584-6	2021	Meanwhile, a high level of intracellular ROS and MDA, accompanied with decreasing GSH and GPX4, displayed a newly developed nano-drug system displayed markedly enhanced ferroptosis.	ros	41-44	glutathione peroxidase 4	Homo sapiens	90-94
34439368-4	2021	OLR1 is a metabolic gene that encodes for the Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), implicated in inflammation, atherosclerosis, ROS, and metabolic disorder-associated carcinogenesis.	ros	156-159	oxidized low density lipoprotein receptor 1	Homo sapiens	103-108
34440751-7	2021	The current literature suggests that ROS/RNS nitrate proNGF and reduce the expression of the proNGF receptor tropomyosin-related kinase A (TrkA), disrupting its downstream survival signalling.	ros	37-40	neurotrophic receptor tyrosine kinase 1	Homo sapiens	139-143
33085980-0	2021	Novel Phenylmethylenecyclohexenone Derivatives as Potent TrxR Inhibitors Display High Antiproliferative Activity and Induce ROS, Apoptosis, and DNA Damage.	ros	124-127	peroxiredoxin 5	Homo sapiens	57-61
34440751-8	2021	ROS/RNS-induced reductions in TrkA expression reduce cell viability, as proNGF loses its neurotrophic function in the absence of TrkA and instead generates apoptotic signalling via the pan-neurotrophin receptor p75NTR.	ros	0-3	neurotrophic receptor tyrosine kinase 1	Homo sapiens	30-34
33754045-15	2021	The KEAP1-NRF2 and mTORC1-cMyc axis are independently activated upon ADSL overexpression and may favor the survival and proliferation of ROS-accumulating cells, favoring DNA damage and tumorigenesis.	ros	137-140	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	26-30
34440751-10	2021	ROS/RNS-induced deficits in microtubule motor function and TrkA expression and signalling may contribute to the vulnerability of the basal forebrain in AD.	ros	0-3	neurotrophic receptor tyrosine kinase 1	Homo sapiens	59-63
34114917-8	2021	After transfection of miR-210 mimics, the attenuation of pyroptosis induced by paeoniflorin was suppressed, which was accompanied by an increase of ROS levels, as well as LDH release, indicating a critical role of miR-210 in pyroptosis in astrocytes.Conclusions: Our findings demonstrated that paeoniflorin improved hypoxia-induced pyroptosis in astrocytes via depressing hif1a/miR-210/caspase1/GSDMD signaling, providing robust evidence for the treatment of hypoxic injury and OSAHS.HighlightsHypoxia induces severe injury and inflammatory response in the rat brain;Hypoxia enhanced pyroptotic level and led to an activation of astrocytes.	ros	148-151	microRNA 210	Rattus norvegicus	22-29
33342222-6	2021	Upon TTX exposure, mitochondria near NaV1.5 channels accumulated more Ca2+ and showed increased ROS production when compared to interfibrillar mitochondria.	ros	96-99	sodium voltage-gated channel alpha subunit 5	Homo sapiens	37-43
33536069-7	2021	The obtained results demonstrated also an obvious reduction in intracellular accumulated ROS and NO, as well as mitigated ER stress through the downregulation of Chop, Perk, Atf6, Ire1, and Xbp1 transcripts upon PTP1B inhibition.	ros	89-92	ATF6	Equus caballus	174-178
33359261-7	2021	These cells showed increased proton leak and uncoupling protein 3 (UCP3) expression that correlated with mitochondrial ROS (mROS) accumulation, mitochondrial membrane potential (MMP) depolarization and expression of PD1.	ros	119-122	uncoupling protein 3	Sus scrofa	45-65
34330116-14	2021	The mechanism of FA-BSANPs/BA promoting apoptosis of breast cancer may be due to its action on the caspase-8/Bid/ROS pathway.	ros	113-116	caspase 8	Homo sapiens	99-108
34234193-10	2021	Our results suggest that metformin in cancer cells differentially regulates cellular ROS levels via AMPK-FOXO3a-MnSOD pathway and combination of metformin/apigenin exerts anticancer activity through DNA damage-induced apoptosis, autophagy and necroptosis by cancer cell-specific ROS amplification.	ros	85-88	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	100-104
34306311-6	2021	Based on the theory, mitochondrial targeting vector sterile alpha- and HEAT/armadillo motif-containing protein 1- (Sarm1-) mtKR has been successfully constructed, and we found that ROS levels have significantly increased after light exposure.	ros	181-184	sterile alpha and TIR motif containing 1	Homo sapiens	115-120
33468664-5	2021	Using multiple mouse models of ROS-induced cancer, we show that Mdm2 phosphorylation by Akt reduces senescence to promote KrasG12D-driven lung cancers and carcinogen-induced papilloma and hepatocellular carcinomas.	ros	31-34	transformed mouse 3T3 cell double minute 2	Mus musculus	64-68
34121036-9	2021	In addition, LPS-induced ROS production was eliminated in apocynin-treated cells, indicating that ROS production was dependent on Nox2.	ros	98-101	cytochrome b-245, beta polypeptide	Mus musculus	130-134
33439743-0	2021	Metformin ameliorates ROS-p53-collagen axis of fibrosis and dyslipidemia in type 2 diabetes mellitus-induced left ventricular injury.	ros	22-25	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	26-29
34604422-1	2021	Background: Epithelial malignancy in lung cancer, which is initiated with myofibroblast differentiation and remodeling, promotes hypoxia and intracellular ROS generation most affected by the prototypical enzyme, NADPH oxidase 4 (NOX4).	ros	155-158	NADPH oxidase 4	Homo sapiens	212-227
33439743-6	2021	In addition, a significant correlation between ROS-p53-collagen axis and glycaemia and hyperlipidaemia was observed.	ros	47-50	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	51-54
33569429-11	2021	Furthermore, the expression levels of RANKL and RANK were increased, while OPG expression was reduced after treatment with VIP in the co-culture of ROS 17/2.8 and rat BMMs.	ros	148-151	TNF receptor superfamily member 11B	Rattus norvegicus	75-78
34604422-1	2021	Background: Epithelial malignancy in lung cancer, which is initiated with myofibroblast differentiation and remodeling, promotes hypoxia and intracellular ROS generation most affected by the prototypical enzyme, NADPH oxidase 4 (NOX4).	ros	155-158	NADPH oxidase 4	Homo sapiens	229-233
34120140-0	2021	G-protein-coupled receptor GPR17 inhibits glioma development by increasing polycomb repressive complex 1-mediated ROS production.	ros	114-117	G protein-coupled receptor 17	Homo sapiens	27-32
33260093-5	2021	As a nanoscale prodrug, SW@DSeSeD protects its payloads from decomposition in bloodstream upon administration, accumulates in liver of ALF mice, then responds to the overexpressed ROS and thereby releases SW033291 as well as a stable dopamine precursor that can transform into dopamine in hepatic cells, thus achieving significant therapeutic efficacy against ALF through inhibiting NLRP3 inflammasome activation and enhancing hepatic regeneration.	ros	180-183	NLR family, pyrin domain containing 3	Mus musculus	383-388
34120140-5	2021	Overexpressing GPR17 inhibits glioma cell proliferation and induces apoptosis by raising ROS levels.	ros	89-92	G protein-coupled receptor 17	Homo sapiens	15-20
33246293-6	2021	DJ-1 deficient mice exhibited greater susceptibility to LPS-induced acute lung injury as demonstrated by increased cellular infiltration, augmented levels of pulmonary cytokines, enhanced ROS levels and oxidized by-products, increased pulmonary edema and cell death.	ros	188-191	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	0-4
34205973-0	2021	The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis.	ros	54-57	Auxin efflux carrier family protein	Arabidopsis thaliana	83-87
33246293-8	2021	Collectively, these results identify DJ-1 as a negative regulator of ROS and inflammation, and suggest its expression protects from sterile lung injury driven by high oxidative stress.	ros	69-72	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	37-41
29895712-5	2018	Thus, we reveal a critical role of USP30 in the clearance of the two major sources of ROS in mammalian cells and in the regulation of both a PINK1-dependent and a PINK1-independent selective autophagy pathway.	ros	86-89	ubiquitin specific peptidase 30	Homo sapiens	35-40
29663491-12	2018	In conclusion, our present study revealed that miR-370 can reduce inflammatory reaction and inhibit the ROS production by targeting TLR4 in THP-1 cells.	ros	104-107	toll like receptor 4	Homo sapiens	132-136
34205973-10	2021	The potential involvement of AtCRK5 protein kinase in the control of auxin-ROS-NO-PIN2-auxin regulatory loop is discussed.	ros	75-78	Auxin efflux carrier family protein	Arabidopsis thaliana	82-86
30046376-9	2018	Furthermore, OMA1/YME1L abnormal degradation was involved in the OPA1 dysfunction, and intervening OMA1/YME1L in H9C2 significantly alleviated mitochondrial fission, ultrastructure damage, and cell apoptosis induced by TNF-alpha and ROS.	ros	233-236	OMA1 zinc metallopeptidase	Mus musculus	13-17
30046376-9	2018	Furthermore, OMA1/YME1L abnormal degradation was involved in the OPA1 dysfunction, and intervening OMA1/YME1L in H9C2 significantly alleviated mitochondrial fission, ultrastructure damage, and cell apoptosis induced by TNF-alpha and ROS.	ros	233-236	OMA1 zinc metallopeptidase	Mus musculus	99-103
33379346-0	2020	Inhibitory Effect of (2R)-4-(4-hydroxyphenyl)-2-butanol 2-O-beta-d-apiofuranosyl-(1 6)-beta-d-glucopyranoside on RANKL-Induced Osteoclast Differentiation and ROS Generation in Macrophages.	ros	158-161	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	113-118
33379346-6	2020	In addition, the protein and gene levels were suppressed of integrin beta3 and CCL4, which play an important role in the osteoclast-induced bone resorption and migration of osteoclasts, and inhibited the production of ROS and restored the expression of antioxidant enzymes such as SOD and CAT lost by RANKL.	ros	218-221	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	301-306
35525345-0	2022	Arsenic exposure elevated ROS promotes energy metabolic reprogramming with enhanced AKT-dependent HK2 expression.	ros	26-29	hexokinase 2	Homo sapiens	98-101
33189721-10	2020	Pretreatment with exogenous leptin largely reduced the mRNA levels of TNFalpha and IL-1beta after hypoxia, while enhancing expression of all other genes and reducing ROS levels.	ros	166-169	leptin	Mus musculus	28-34
29930336-8	2018	Furthermore, naringin counteracted fructose-induced cardiomyocyte apoptosis, and this function of naringin was linked to its ability to inhibit ROS-dependent ATM-mediated p53 signaling.	ros	144-147	transformation related protein 53, pseudogene	Mus musculus	171-174
29653689-11	2018	In conclusion, this study shows that intracellular ROS, not extracellular ROS such as H2O2, plays a crucial role in facilitating platelet aggregation via LPS/TLR4 pathway, and this process was involved in AKT, PKC and p38 phosphorylation but not cGMP/cAMP pathway.	ros	51-54	toll like receptor 4	Homo sapiens	158-162
35525345-8	2022	Further studies showed accumulated ROS determined the metabolic reprogramming via activating AKT and then increasing HK2 expression.	ros	35-38	hexokinase 2	Homo sapiens	117-120
29477336-13	2018	These results suggest that some impairment in the regulation mechanism of FoxO-1a phosphorylation is responsible for abnormal catalase expression and that a significant decrease in the level of catalase with aging decisively affects the metabolic balance of ROS; thus, ROS that cannot be metabolized contributes to the accelerated aging of SAMP10 mice.	ros	258-261	forkhead box O1	Mus musculus	74-81
29477336-13	2018	These results suggest that some impairment in the regulation mechanism of FoxO-1a phosphorylation is responsible for abnormal catalase expression and that a significant decrease in the level of catalase with aging decisively affects the metabolic balance of ROS; thus, ROS that cannot be metabolized contributes to the accelerated aging of SAMP10 mice.	ros	269-272	forkhead box O1	Mus musculus	74-81
35318880-0	2022	TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination.	ros	15-18	unc-51 like autophagy activating kinase 1	Homo sapiens	101-105
29348462-8	2018	Administration of PL and APR-246 significantly suppresses GSTP1 activity, resulting in the accumulation of ROS, depletion of GSH, elevation of GSSG, and DNA damage.	ros	107-110	glutathione S-transferase pi 1	Homo sapiens	58-63
29348462-9	2018	Ectopic expression of GSTP1 or pre-treatment with antioxidant N-acetyl-L-cysteine (NAC) abrogates the ROS elevation and decreases DNA damage, apoptosis, and autophagic cell death prompted by PL/APR-246.	ros	102-105	glutathione S-transferase pi 1	Homo sapiens	22-27
33206581-10	2021	Moreover, inhibition of HIF1A (hypoxia inducible factor 1 subunit alpha) caused suppression of HMOX1 expression in MSC3D, indicating that the HIF1A-HMOX1 axis plays a crucial role in the modulation of ROS production and autophagy induction in MSC3D.	ros	201-204	hypoxia inducible factor 1, alpha subunit	Mus musculus	24-29
33206581-10	2021	Moreover, inhibition of HIF1A (hypoxia inducible factor 1 subunit alpha) caused suppression of HMOX1 expression in MSC3D, indicating that the HIF1A-HMOX1 axis plays a crucial role in the modulation of ROS production and autophagy induction in MSC3D.	ros	201-204	hypoxia inducible factor 1, alpha subunit	Mus musculus	142-147
35318880-12	2022	CONCLUSIONS: This study identified that TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination, which could potentially give rise to a new strategy for the treatment of cardiac infarction.	ros	55-58	unc-51 like autophagy activating kinase 1	Homo sapiens	141-145
33172542-4	2020	SOCS1 up-regulated an ROS-scavenging protein, thioredoxin, via enhanced expression and binding of NRF-2 to the thioredoxin promoter.	ros	22-25	suppressor of cytokine signaling 1	Homo sapiens	0-5
33172542-4	2020	SOCS1 up-regulated an ROS-scavenging protein, thioredoxin, via enhanced expression and binding of NRF-2 to the thioredoxin promoter.	ros	22-25	thioredoxin	Homo sapiens	46-57
29751604-7	2018	We found that Graminex pollen was able to reduce radical oxygen species (ROS) production by PC3 cells and MDA, NFkappaB mRNA, and PGE2 levels, in rat prostate specimens.	ros	73-76	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	92-95
33172542-4	2020	SOCS1 up-regulated an ROS-scavenging protein, thioredoxin, via enhanced expression and binding of NRF-2 to the thioredoxin promoter.	ros	22-25	thioredoxin	Homo sapiens	111-122
35358404-9	2022	TBK1 null neutrophils have no defect in recruitment to the infected lung but show impaired activation of p65/NF-kappaB and STAT1 and lower expression of ROS, IFNgamma, and IL12p40.	ros	153-156	TANK-binding kinase 1	Mus musculus	0-4
33172542-6	2020	Notably thioredoxin ablation promoted NLRP3 inflammasome activation and restored the SOCS1-mediated inhibition of ROS and cytokine synthesis induced by LPS.	ros	114-117	thioredoxin	Homo sapiens	8-19
33172542-6	2020	Notably thioredoxin ablation promoted NLRP3 inflammasome activation and restored the SOCS1-mediated inhibition of ROS and cytokine synthesis induced by LPS.	ros	114-117	suppressor of cytokine signaling 1	Homo sapiens	85-90
33172542-7	2020	The results demonstrate that the anti-inflammatory mechanisms of SOCS1 and SOCS3 in macrophages are mediated via NRF-2-mediated thioredoxin upregulation resulting in the downregulation of ROS signal.Thus, our study supports the anti-oxidant role of SOCS1 and SOCS3 in the exquisite regulation of macrophage activation under oxidative stress.	ros	188-191	suppressor of cytokine signaling 1	Homo sapiens	65-70
33172542-7	2020	The results demonstrate that the anti-inflammatory mechanisms of SOCS1 and SOCS3 in macrophages are mediated via NRF-2-mediated thioredoxin upregulation resulting in the downregulation of ROS signal.Thus, our study supports the anti-oxidant role of SOCS1 and SOCS3 in the exquisite regulation of macrophage activation under oxidative stress.	ros	188-191	thioredoxin	Homo sapiens	128-139
29735887-0	2018	Ursolic Acid Attenuates Atherosclerosis in ApoE-/- Mice: Role of LOX-1 Mediated by ROS/NF-kappaB Pathway.	ros	83-86	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	65-70
29735887-12	2018	Taken together, these results suggested that UA, with anti-atherosclerotic activity through inhibition of LOX-1 mediated by ROS/NF-kappaB signaling pathways, may become a valuable vascular protective candidate for the treatment of atherosclerosis.	ros	124-127	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	106-111
29720213-11	2018	ROS was required for PM2.5-induced IL-1beta production and NLRP3 inflammasome activation in oAbeta-stimulated microglia.	ros	0-3	interleukin 1 alpha	Homo sapiens	35-43
35306710-10	2022	Furthermore, iron limitation and inhibition of lipid-ROS accumulation suppressed the ER-phagy.	ros	53-56	epiregulin	Homo sapiens	85-87
29417167-0	2018	Maternal NO2 exposure induces cardiac hypertrophy in male offspring via ROS-HIF-1alpha transcriptional regulation and aberrant DNA methylation modification of Csx/Nkx2.5.	ros	72-75	hypoxia inducible factor 1, alpha subunit	Mus musculus	76-86
29417167-6	2018	The cardiac-specific transcription factor Csx/Nkx2.5 played an important role in the induction of cardiac hypertrophy and cardiomyocyte injury, and the action was associated with ROS-HIF-1alpha transcriptional regulation and DNA hypomethylation modification.	ros	179-182	hypoxia inducible factor 1, alpha subunit	Mus musculus	183-193
29452246-6	2018	In this study we have identified Prdx1, a known scavenger of ROS, to be expressed in pre-hypertrophic chondrocytes in a BMP signaling-dependent manner.	ros	61-64	peroxiredoxin 1	Homo sapiens	33-38
29636860-6	2018	Moreover, YM155 increased the intracellular ROS levels, and pretreatment with either NAC or GSH partially reversed the YM155-induced ROS accumulation and apoptosis only in the parental A2780 cells, but not in the resistant A2780/Taxol cells.	ros	133-136	synuclein alpha	Homo sapiens	85-88
29531225-4	2018	PON2 deficiency aggravates mitochondrial ROS formation, systemic inflammation, and atherosclerosis.	ros	41-44	paraoxonase 2	Mus musculus	0-4
29523849-6	2018	Furthermore, the antioxidant compound Sulforaphane downregulates p63-iRHOM2 expression, leading to reduced proliferation, inflammation, survival and ROS production.	ros	149-152	tumor protein p63	Homo sapiens	65-68
29309588-10	2018	Excessive post-translational oxidation of protein disulfide isomerase (PDI), altered folding capacitance and ROS accumulation, and ER stress were also decreased in the presence of Tmbim6.	ros	109-112	transmembrane BAX inhibitor motif containing 6	Mus musculus	180-186
28386847-8	2018	Pharmacological suppression of sAC during reperfusion reduced cellular cAMP and ameliorated reperfusion-induced mitochondrial apoptosis and ROS formation.	ros	140-143	adenylate cyclase 10	Rattus norvegicus	31-34
28386847-10	2018	Further analysis revealed a role of protein kinase A (PKA), a major downstream target of sAC, in reperfusion-induced neuronal apoptosis and ROS formation.	ros	140-143	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	36-52
28386847-10	2018	Further analysis revealed a role of protein kinase A (PKA), a major downstream target of sAC, in reperfusion-induced neuronal apoptosis and ROS formation.	ros	140-143	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	54-57
28386847-10	2018	Further analysis revealed a role of protein kinase A (PKA), a major downstream target of sAC, in reperfusion-induced neuronal apoptosis and ROS formation.	ros	140-143	adenylate cyclase 10	Rattus norvegicus	89-92
29348461-8	2018	Apoptosis is completely prevented by mPTP inhibition, almost fully inhibited by blocking ROS and unaffected by inhibition of mitochondrial fission, suggesting that apoptosis in breast cancer cells due to Cdk5 loss occurs via a novel mPTP-dependent mechanism that acts primarily through ROS increase.	ros	89-92	cyclin dependent kinase 5	Homo sapiens	204-208
29348461-8	2018	Apoptosis is completely prevented by mPTP inhibition, almost fully inhibited by blocking ROS and unaffected by inhibition of mitochondrial fission, suggesting that apoptosis in breast cancer cells due to Cdk5 loss occurs via a novel mPTP-dependent mechanism that acts primarily through ROS increase.	ros	286-289	cyclin dependent kinase 5	Homo sapiens	204-208
29362078-6	2018	Arabidopsis pete1 and pete2 mutants showed ROS-sensitive phenotypes that could be restored by expression of SsPETE2 or AtPETEs.	ros	43-46	plastocyanin 1	Arabidopsis thaliana	12-17
29452639-3	2018	Mitochondrial MDM2 represses the transcription of NADH-dehydrogenase 6 (MT-ND6) in vitro and in vivo, impinging on respiratory complex I activity and enhancing mitochondrial ROS production.	ros	174-177	transformed mouse 3T3 cell double minute 2	Mus musculus	14-18
29098483-0	2018	Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling.	ros	114-117	fibronectin type III domain containing 5	Homo sapiens	0-6
29098483-9	2018	Taken together, our results reveal that irisin alleviates AGEs-induced inflammation and endothelial dysfunction via inhibiting ROS-NLRP3 inflammasome signaling, suggest a likely mechanism for irisin-induced therapeutic effect in vascular complications of diabetes.	ros	127-130	fibronectin type III domain containing 5	Homo sapiens	40-46
29098483-9	2018	Taken together, our results reveal that irisin alleviates AGEs-induced inflammation and endothelial dysfunction via inhibiting ROS-NLRP3 inflammasome signaling, suggest a likely mechanism for irisin-induced therapeutic effect in vascular complications of diabetes.	ros	127-130	fibronectin type III domain containing 5	Homo sapiens	192-198
32898504-7	2020	We found that HL-1 cardiomyocytes moderately expressed the GLP-1 receptor, and co-treatment with Liraglutide ameliorated IL-1beta-induced cellular ROS production and NADPH oxidase (NOX)-4 expression.	ros	147-150	interleukin 1 alpha	Homo sapiens	121-129
32803561-7	2020	Moreover, the exogenous antioxidant application of the LA from the LCNs can prevent ROS damage, which was demonstrated by this study with the less myeloperoxidase (MPO) activity and decrease in cytokine levels (TNF-alpha and IL-1beta) generated by the oxidative stress modulation.	ros	84-87	interleukin 1 alpha	Homo sapiens	225-233
32750407-4	2020	Pharmacologicalinhibition of TGF-betaRI signaling markedly improved heart and liver function and increased overall survival of animals exposed to multiple NSAIDs, effects likely mediated by reductions in NOX-dependent ROS generation.	ros	218-221	transforming growth factor beta receptor 1	Homo sapiens	29-39
33274006-6	2020	Knockdown of MALAT1 could significantly reduce ROS, prevent EMT, arrest S phase cell cycle, and suppress the expression of total NRF2 and its nucleus translocation in LECs.	ros	47-50	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	13-19
33251225-0	2020	Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFkappaB/ROS Signaling Pathways.	ros	112-115	adiponectin, C1Q and collagen domain containing	Mus musculus	0-11
33251225-0	2020	Adiponectin Inhibits NLRP3 Inflammasome Activation in Nonalcoholic Steatohepatitis via AMPK-JNK/ErK1/2-NFkappaB/ROS Signaling Pathways.	ros	112-115	NLR family, pyrin domain containing 3	Mus musculus	21-26
33251225-11	2020	Moreover, the expression levels of NLRP3 inflammasome pathway molecules (NFkappaB and ROS) were upregulated, while the phosphorylation levels of AMPK, JNK, and Erk1/2 were downregulated in adiponectin-KO mice compared with wild-type mice.	ros	86-89	NLR family, pyrin domain containing 3	Mus musculus	35-40
33251225-14	2020	Adiponectin could abolish PA-mediated inflammasome activation and decrease ROS production, which was reversed by AMPK inhibitor (compound C).	ros	75-78	adiponectin, C1Q and collagen domain containing	Mus musculus	0-11
33251225-15	2020	Furthermore, the results showed that the inhibitory effect of adiponectin on PA-mediated inflammasome activation was regulated by AMPK-JNK/ErK1/2-NFkappaB/ROS signaling pathway.	ros	155-158	adiponectin, C1Q and collagen domain containing	Mus musculus	62-73
33046554-5	2020	This pathway activation reduces ROS generated by QR2 enzymatic activity, a process that alters the intrinsic properties of CA1 interneurons 3 h following learning, in a form of oxidative eustress.	ros	32-35	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	49-52
32934346-7	2020	Treatment with Quer (1, 2, 5 muM) dose-dependently inhibited RANKL-induced osteoclastogenesis through promoting the expression of antioxidant hormone stanniocalcin 1 (STC1) and decreasing ROS generation; knockdown of STC1 blocked the inhibitory effect of Quer on ROS generation.	ros	188-191	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	61-66
32934346-7	2020	Treatment with Quer (1, 2, 5 muM) dose-dependently inhibited RANKL-induced osteoclastogenesis through promoting the expression of antioxidant hormone stanniocalcin 1 (STC1) and decreasing ROS generation; knockdown of STC1 blocked the inhibitory effect of Quer on ROS generation.	ros	263-266	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	61-66
32902155-0	2020	Antrodia camphorata polysaccharide resists 6-OHDA-induced dopaminergic neuronal damage by inhibiting ROS-NLRP3 activation.	ros	101-104	NLR family, pyrin domain containing 3	Mus musculus	105-110
32902155-5	2020	Therefore, in this study, we focused on ROS-NLRP3 signal to investigate the mechanism of 6-OHDA-induced apoptosis of dopaminergic neurons MES23.5 and the protective effects of ACP on dopaminergic neurons.	ros	40-43	NLR family, pyrin domain containing 3	Mus musculus	44-49
32902155-6	2020	RESULT: 6-OHDA could further activate the expression of inflammasome NLRP3 by inducing ROS, thereby resulting in apoptosis of MES23.5 cells.	ros	87-90	NLR family, pyrin domain containing 3	Mus musculus	69-74
32902155-8	2020	Animal experiments also confirmed that ACP intervention could reduce the activation level of ROS-NLRP3 in the substantia nigra-striatum and improve the exercise capacity of PD mice.	ros	93-96	NLR family, pyrin domain containing 3	Mus musculus	97-102
32902155-9	2020	CONCLUSION: Our study validated that 6-OHDA could induce apoptosis of dopaminergic neurons via ROS-NLRP3 activation.	ros	95-98	NLR family, pyrin domain containing 3	Mus musculus	99-104
32882342-0	2020	Decreased UCP-1 expression in beige adipocytes from adipose-derived stem cells of type 2 diabetes patients associates with mitochondrial ROS accumulation during obesity.	ros	137-140	uncoupling protein 1	Homo sapiens	10-15
32882342-11	2020	CONCLUSIONS: In summary, compromised UCP1 expression in beige adipocytes of T2DM patients may cause increase of mitochondrial ROS.	ros	126-129	uncoupling protein 1	Homo sapiens	37-41
32805340-5	2020	When HepG2 cells were pretreated with ROS (NAC) and ERS (4-PBA) inhibitors separately, the activation of NLRP3 inflammasome was inhibited.	ros	38-41	synuclein alpha	Homo sapiens	43-46
33059972-9	2020	Overexpression of IFI6 promoted cell proliferation and reduced cell apoptosis as well as ROS production following radiation, and conversely, increased the radiosensitivity of HaCaT and human skin fibroblast (WS1).	ros	89-92	interferon alpha inducible protein 6	Homo sapiens	18-22
33116413-8	2020	Results: Compared with the control group, IL-1beta treatment (20nM) for 24 h significantly decreased cell viability and insulin secretion, damaged mitochondrial function and increased ROS activity.	ros	184-187	interleukin 1 alpha	Mus musculus	42-50
33132912-0	2020	alpha-Cyperone Confers Antidepressant-Like Effects in Mice via Neuroplasticity Enhancement by SIRT3/ROS Mediated NLRP3 Inflammasome Deactivation.	ros	100-103	NLR family, pyrin domain containing 3	Mus musculus	113-118
32925168-6	2020	Tumor-infiltrating Trx1+ NK cells were present in patients with NSCLC with elevated ROS levels in the tumor.	ros	84-87	thioredoxin	Homo sapiens	19-23
32696439-4	2020	Dynamin-related protein 1 (Drp1)-mediated mitochondrial fragmentation leads to excess ROS generation, which is implicated in the pathogenesis of neuropathic pain.	ros	86-89	dynamin 1 like	Homo sapiens	0-25
32696439-4	2020	Dynamin-related protein 1 (Drp1)-mediated mitochondrial fragmentation leads to excess ROS generation, which is implicated in the pathogenesis of neuropathic pain.	ros	86-89	dynamin 1 like	Homo sapiens	27-31
32696439-8	2020	We summarized a Drp1-mitochondrial fission-ROS cycle that potentially functions in neuropathic pain and is regulated by posttranslational modifications and Ca2+.	ros	43-46	dynamin 1 like	Homo sapiens	16-20
35395625-6	2022	Elevated NOX4 expression in Piezo1-deficient MuSCs increases ROS levels and DNA damage, causing P53-dependent cellular senescence and cell death.	ros	61-64	NADPH oxidase 4	Mus musculus	9-13
32648010-0	2020	Characterization on TaMPK14, an MAPK family gene of wheat, in modulating N-starvation response through regulating N uptake and ROS homeostasis.	ros	127-130	mitogen-activated protein kinase 7-like	Nicotiana tabacum	32-36
35306208-7	2022	Apelin-13-induced MCU-dependent mitochondrial calcium uptake further increased mitochondrial ROS (mtROS) concentrations and promoted mitophagy, which can be evidenced through the upregulation of the Dynamin-related protein 1(Drp1), PTEN-induced kinase 1 (PINK1), and Parkin.	ros	93-96	apelin	Mus musculus	0-6
35306208-7	2022	Apelin-13-induced MCU-dependent mitochondrial calcium uptake further increased mitochondrial ROS (mtROS) concentrations and promoted mitophagy, which can be evidenced through the upregulation of the Dynamin-related protein 1(Drp1), PTEN-induced kinase 1 (PINK1), and Parkin.	ros	93-96	mitochondrial calcium uniporter	Mus musculus	18-21
32966780-4	2020	In MM cells, FAM46C expression raises secretory capacity beyond sustainability, inducing ROS accumulation, ATP shortage, and cell death.	ros	89-92	terminal nucleotidyltransferase 5C	Homo sapiens	13-19
35620579-11	2022	Additionally, DDAH1 deficiency also increased ROS generation, MDA, and IRE-1alpha expression.	ros	46-49	dimethylarginine dimethylaminohydrolase 1	Mus musculus	14-19
32450005-0	2020	Loss of glutathione peroxidase 3 induces ROS and contributes to prostatic hyperplasia in Nkx3.1 knockout mice.	ros	41-44	glutathione peroxidase 3	Mus musculus	8-32
32450005-10	2020	Increased ROS and decreased SOD activity were observed in Nkx3.1-/-; Gpx3-/- mice at 12 months of age.	ros	10-13	NK3 homeobox 1	Mus musculus	58-64
35615575-5	2022	FFA triggers a large amount of ROS (generated from NOX4 and damaged mitochondria), promoting the ZNF24 expression and suppressing ZN24 sumoylation, both of which enhance the PD-L1 transcription and expression.	ros	31-34	NADPH oxidase 4	Homo sapiens	51-55
32450005-10	2020	Increased ROS and decreased SOD activity were observed in Nkx3.1-/-; Gpx3-/- mice at 12 months of age.	ros	10-13	glutathione peroxidase 3	Mus musculus	69-73
32404277-4	2020	Genetic or pharmacological inhibition of ATGL in MEFs causes impaired FA oxidation, decreased ROS production, and a substrate switch from FA to glucose leading to decreased AMPK-mTOR signaling and higher cell proliferation rates.	ros	94-97	patatin-like phospholipase domain containing 2	Mus musculus	41-45
32632148-0	2020	IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.	ros	73-76	IQ motif containing GTPase activating protein 1	Homo sapiens	0-6
32632148-12	2020	CONCLUSIONS: Our study indicated an important mechanism by which upregulated IQGAP1 by HBV promoted anoikis resistance, migration and invasion of HCC cells through Rac1-dependent ROS accumulation and activation of Src/FAK signalling, suggesting IQGAP1 as a prognostic indicator and a novel therapeutic target in HCC patients with HBV infection.	ros	179-182	IQ motif containing GTPase activating protein 1	Homo sapiens	77-83
32687844-11	2020	Furthermore, autophagy inhibitors or NAC could counteract the action of DpdtC, indicating that ferrtinophagy-mediated ROS played an important role in the cellular events.	ros	118-121	synuclein alpha	Homo sapiens	37-40
32512010-8	2020	Collectively, our results demonstrates that HG-induced over production of ROS, disrupts the antioxidant defence mechanism and mitochondrial dysfunction, leading to alterations of inflammatory mediators and neurodegenerative markers through the ERK1/2-Akt-tuberin-mTOR dependent signalling pathway in RGC-5 cells.	ros	74-77	TSC complex subunit 2	Mus musculus	255-262
32512010-8	2020	Collectively, our results demonstrates that HG-induced over production of ROS, disrupts the antioxidant defence mechanism and mitochondrial dysfunction, leading to alterations of inflammatory mediators and neurodegenerative markers through the ERK1/2-Akt-tuberin-mTOR dependent signalling pathway in RGC-5 cells.	ros	74-77	mechanistic target of rapamycin kinase	Mus musculus	263-267
32824997-9	2020	Furthermore, piceatannol visibly suppressed ROS formation, as triggered by VEGF.	ros	44-47	vascular endothelial growth factor Aa	Danio rerio	75-79
32454055-6	2020	Our study showed that EP targets PC3 cells via inducing ROS and apoptosis activation.	ros	56-59	proprotein convertase subtilisin/kexin type 1	Homo sapiens	33-36
32103437-6	2020	Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1beta secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger).	ros	123-126	synuclein alpha	Homo sapiens	223-226
32103437-6	2020	Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1beta secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger).	ros	228-231	interleukin 1 alpha	Homo sapiens	155-163
32103437-6	2020	Moreover, measurement by confocal microscopy and flow cytometry assay indicates that Ti ions can promote the production of ROS, while NLRP3 expression and IL-1beta secretion are reduced after treatment of Jurkat cells with NAC (ROS scavenger).	ros	228-231	synuclein alpha	Homo sapiens	223-226
32792865-4	2020	Additionally, MAOA knockout inhibited HPV-16 E7-induced migration, invasion, and EMT, and significantly reduced HPV-16 E7-induced ROS generation and HIF-1alpha protein accumulation via promoting its degradation.	ros	130-133	monoamine oxidase A	Homo sapiens	14-18
32470468-9	2020	Additionally, both conditioned medium from H9c2 cardiomyocytes exposed to hydrogen peroxide (H9c2-H2O2-CM) and combination of mtDNA and ATP (mtDNA-ATP) increased the expression of NLRP3 and cleaved caspase-1 (p10) as well as intracellular ROS production in RAW264.7 macrophages, which were abrogated by Met treatment.	ros	239-242	NLR family, pyrin domain containing 3	Mus musculus	180-185
32470468-11	2020	Collectively, these findings suggest that Met protects against ischaemic myocardial injury through alleviating autophagy-ROS-NLRP3 axis-mediated inflammatory response in macrophages.	ros	121-124	NLR family, pyrin domain containing 3	Mus musculus	125-130
32723812-5	2020	Independently of its previously identified role in mitophagy, FUNDC1 enabled LonP1 proteostasis, which in turn preserved complex V function and decreased ROS generation.	ros	154-157	lon peptidase 1, mitochondrial	Homo sapiens	77-82
32708927-0	2020	NME3 Regulates Mitochondria to Reduce ROS-Mediated Genome Instability.	ros	38-41	NME/NM23 nucleoside diphosphate kinase 3	Homo sapiens	0-4
32585463-8	2020	The ox-LDL-induced mitochondrial damage, indicated as increase in mitochondrial ROS production, decrease in mitochondrial membrane potential and elevation of mitochondrial DNA release, was significantly reversed by MDM2 downregulation and worsened by MDM2 overexpression.	ros	80-83	transformed mouse 3T3 cell double minute 2	Mus musculus	215-219
32388247-6	2020	Significant reduction in ROS and inflammatory cytokine production (i.e., IL-6, IL-1beta) was observed, including a reduction in ERK1/2 phosphorylation in neutrophils stimulated with LPS and fMLP in the presence of Fbln7-C compared to untreated controls.	ros	25-28	fibulin 7	Homo sapiens	214-219
32388247-8	2020	Additionally, neutrophils infiltrating into the inflamed peritoneum of Fbln7-C administered animals expressed lower levels CD11b marker, IL-6, and produced lower levels of ROS upon stimulation with PMA compared to untreated controls.	ros	172-175	fibulin 7	Homo sapiens	71-76
32706035-0	2020	MiR-122 regulates cell apoptosis and ROS by targeting DJ-1 in renal ischemic reperfusion injury rat models.	ros	37-40	microRNA 122	Rattus norvegicus	0-7
32427405-0	2020	Kaempferol blocks neutrophil extracellular traps formation and reduces tumour metastasis by inhibiting ROS-PAD4 pathway.	ros	103-106	MMTV LTR integration site 4	Mus musculus	107-111
32438202-6	2020	RESULTS: We found ROS-NLRP3 singaling was activated in BV2 cells at OGD/R 24 h. Importantly, microglial NLRP3 activation was essential for NLRP3 activation in PC12 cells under microglial-neuronal co-culture circumstance, which has been confirmed to induced neuronal apoptosis.	ros	18-21	NLR family, pyrin domain containing 3	Mus musculus	22-27
32606806-11	2020	Additionally, we found that SSPH I could mediate the activation of MAPK/ERK1/2 signaling pathway, and the use of NAC (ROS inhibitor) and U0126 (MEK1/2 inhibitor) converted the effect of SSPH I on apoptosis and autophagy in HepG2 cells.	ros	118-121	synuclein alpha	Homo sapiens	113-116
32572011-7	2020	The use of antioxidants and several antagonists revealed that ET-1 effect on senescence and fibrosis depended on ROS production and activation of PI3K-AKT-GSK pathway.	ros	113-116	endothelin 1	Mus musculus	62-66
32575551-7	2020	The results indicated that CAT silencing promoted ROS production and apoptosis by up-regulating the Bcl-2-associated X protein (BAX) and Caspase-3 genes both at the transcriptional and translational levels.	ros	50-53	BCL2 associated X, apoptosis regulator	Bos taurus	100-126
32575551-7	2020	The results indicated that CAT silencing promoted ROS production and apoptosis by up-regulating the Bcl-2-associated X protein (BAX) and Caspase-3 genes both at the transcriptional and translational levels.	ros	50-53	BCL2 associated X, apoptosis regulator	Bos taurus	128-131
32528039-0	2020	Author Correction: Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation.	ros	94-97	Jun dimerization protein 2	Homo sapiens	19-23
32528039-0	2020	Author Correction: Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation.	ros	94-97	solute carrier family 7 member 11	Homo sapiens	125-128
32528039-0	2020	Author Correction: Jdp2-deficient granule cell progenitors in the cerebellum are resistant to ROS-mediated apoptosis through xCT/Slc7a11 activation.	ros	94-97	solute carrier family 7 member 11	Homo sapiens	129-136
29208272-11	2018	Due to the ROS, iNOS, COX-2, and nuclear factor-kappa light chain, the triggered B cells (NF-kB) transcriptional action was decreased.	ros	11-14	nuclear factor kappa B subunit 1	Rattus norvegicus	90-95
29417757-0	2018	Natriuretic peptide receptor-C-mediated attenuation of vascular smooth muscle cell hypertrophy involves Gqalpha/PLCbeta1 proteins and ROS-associated signaling.	ros	134-137	natriuretic peptide receptor 3	Rattus norvegicus	0-30
29417757-3	2018	The aim of this study was to investigate whether C-ANP4-23 , a natriuretic peptide receptor-C (NPR-C) ligand that was shown to inhibit vasoactive peptide-induced enhanced protein synthesis in A10 VSMC could also attenuate hypertrophy of VSMC isolated from rat model of cardiac hypertrophy and to further explore the possible involvement of Gqalpha/PLCbeta1 proteins and ROS-mediated signaling in this effect.	ros	370-373	natriuretic peptide receptor 3	Rattus norvegicus	63-93
29417757-3	2018	The aim of this study was to investigate whether C-ANP4-23 , a natriuretic peptide receptor-C (NPR-C) ligand that was shown to inhibit vasoactive peptide-induced enhanced protein synthesis in A10 VSMC could also attenuate hypertrophy of VSMC isolated from rat model of cardiac hypertrophy and to further explore the possible involvement of Gqalpha/PLCbeta1 proteins and ROS-mediated signaling in this effect.	ros	370-373	natriuretic peptide receptor 3	Rattus norvegicus	95-100
29348517-7	2018	NOX5 was highly expressed in U937-NDRG2 cells and contributed to ROS production after cisplatin treatment.	ros	65-68	NADPH oxidase 5	Homo sapiens	0-4
29348517-7	2018	NOX5 was highly expressed in U937-NDRG2 cells and contributed to ROS production after cisplatin treatment.	ros	65-68	NDRG family member 2	Homo sapiens	34-39
29348517-8	2018	ROS scavenging or NOX5-knockdown successfully inhibited the sensitivity of U937-NDRG2 cells to cisplatin.	ros	0-3	NDRG family member 2	Homo sapiens	80-85
28918503-7	2018	Furthermore, the blockade of CoQ0-induced ROS production by antioxidant NAC pretreatment substantially attenuated CoQ0-induced apoptosis.	ros	42-45	synuclein alpha	Homo sapiens	72-75
28982613-0	2018	Klotho protects the heart from hyperglycemia-induced injury by inactivating ROS and NF-kappaB-mediated inflammation both in vitro and in vivo.	ros	76-79	Klotho	Rattus norvegicus	0-6
28982613-5	2018	Klotho pretreatment effectively inhibited high glucose-induced inflammation, ROS generation, apoptosis, mitochondrial dysfunction, fibrosis and hypertrophy in both H9c2 cells and neonatal cardiomyocytes.	ros	77-80	Klotho	Rattus norvegicus	0-6
30537740-8	2018	In vitro, Mst1 upregulation induced mitochondrial damage including mitochondrial potential reduction, ROS overloading, cyt-c liberation and caspase-9 apoptotic pathway activation.	ros	102-105	macrophage stimulating 1	Homo sapiens	10-14
29071589-6	2018	Furthermore, concomitant treatments with melatonin and CIS significantly enhanced the mitochondrial structure and function damage, substantially augmented the caspase-9-dependent mitochondrial apoptosis with evidenced by lower mitochondria membrane potential, higher mitochondria ROS, and more pro-apoptotic proteins compared to the treatment with CIS alone.	ros	280-283	caspase 9	Homo sapiens	159-168
35571237-9	2022	In conclusion, our findings illustrated that ROS-mediated downregulation of miR-150-5p led to CS-induced COPD by inhibiting IRE1alpha expression, suggesting to serve as a useful biomarker for diagnosing and treating COPD.	ros	45-48	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	124-133
35405526-8	2022	Ni-induced ROS prevented AMPK activation.	ros	11-14	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	25-29
32087304-8	2020	The drugs synergized to elevate ROS production; activation of ATM was ROS-dependent.	ros	32-35	ATM serine/threonine kinase	Homo sapiens	62-65
32087304-8	2020	The drugs synergized to elevate ROS production; activation of ATM was ROS-dependent.	ros	70-73	ATM serine/threonine kinase	Homo sapiens	62-65
35557943-0	2022	Mitochondrial ROS in Slc4a11 KO Corneal Endothelial Cells Lead to ER Stress.	ros	14-17	solute carrier family 4, sodium bicarbonate transporter-like, member 11	Mus musculus	21-28
32087304-12	2020	Collectively, our data demonstrate that lenvatinib and entinostat interact to kill liver cancer cells via ROS-dependent activation of ATM and inactivation of eIF2alpha, resulting in greater levels of toxic autophagosome formation and reduced expression of protective mitochondrial proteins.	ros	106-109	ATM serine/threonine kinase	Homo sapiens	134-137
32289481-7	2020	Results illuminated that oroxylin A inhibited NLRP3 inflammasome activation by reducing ROS accumulation.	ros	88-91	NLR family, pyrin domain containing 3	Mus musculus	46-51
35624697-7	2022	Further pharmacological research showed that 12b bound to Transferrin receptor 1 (TfR1) directly caused iron deprivation and ROS imbalance along with the degradations of several oncoproteins, especially FGFR1, through the proteasome pathway; thus, inducing cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells.	ros	125-128	transferrin receptor	Homo sapiens	58-80
32509141-5	2020	Mechanistically, we showed that apatinib suppressed glutathione to generate ROS via the downregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and maintained an antitumor effect at a low level of VEGFR2 in ovarian cancer, suggesting that combination of apatinib with Nrf2 inhibitor may be a promising therapy strategy for patients with ovarian cancer.	ros	76-79	heme oxygenase 1	Homo sapiens	161-177
32509141-5	2020	Mechanistically, we showed that apatinib suppressed glutathione to generate ROS via the downregulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway and maintained an antitumor effect at a low level of VEGFR2 in ovarian cancer, suggesting that combination of apatinib with Nrf2 inhibitor may be a promising therapy strategy for patients with ovarian cancer.	ros	76-79	heme oxygenase 1	Homo sapiens	179-183
35624697-7	2022	Further pharmacological research showed that 12b bound to Transferrin receptor 1 (TfR1) directly caused iron deprivation and ROS imbalance along with the degradations of several oncoproteins, especially FGFR1, through the proteasome pathway; thus, inducing cell cycle arrest and apoptosis in MDA-MB-231 breast cancer cells.	ros	125-128	transferrin receptor	Homo sapiens	82-86
35468924-7	2022	Furthermore, TLR4 and SARM1 modulated ROS production, which was induced by cell death in response to cisplatin.	ros	38-41	sterile alpha and TIR motif containing 1	Homo sapiens	22-27
32385404-0	2020	Expansin-like Exl1 from Pectobacterium is a virulence factor required for host infection, and induces a defence plant response involving ROS, and jasmonate, ethylene and salicylic acid signalling pathways in Arabidopsis thaliana.	ros	137-140	Phosphate-responsive 1 family protein	Arabidopsis thaliana	14-18
32385404-8	2020	We found that Exl1 acts on the plant tissue, probably by remodelling of a cell wall component or altering the barrier properties of the cell wall inducing a plant defence response, which results in the production of ROS and the induction of marker genes of the JA, ET and SA signalling pathways in Arabidopsis thaliana.	ros	216-219	Phosphate-responsive 1 family protein	Arabidopsis thaliana	14-18
35440572-7	2022	In elucidating the cellular mechanisms, we found that stroke triggered activation of NADPH oxidase (NOX)-NF-kappaB signaling and ROS-mediated LCN2 expression.	ros	129-132	lipocalin 2	Mus musculus	142-146
32119963-13	2020	SIGNIFICANCE: APG can ameliorate CCl4-induced liver fibrosis via VEGF-mediated FAK phosphorylation through the MAPKs, PI3K/Akt, HIF-1, ROS, and eNOS pathways, which may hopefully become the anti-liver fibrosis activity of natural product.	ros	135-138	vascular endothelial growth factor A	Rattus norvegicus	65-69
29851009-4	2018	It was demonstrated that in isolated brown adipose tissue mitochondria (1) mGPDH enzyme activity is maximal at free calcium ion concentrations in the 350 nM-1 muM range, (2) that ROS production also peaks in the 10-100 nM range in the presence of a UCP1 inhibitory ligand (GDP) but wanes with further increasing calcium concentration, and (3) that oxygen consumption rates peak in the 10-100 nM range with rates being maintained at higher calcium concentrations.	ros	179-182	uncoupling protein 1	Homo sapiens	249-253
29344296-12	2018	Importantly, we demonstrated that CDK16 promotes radioresistance by suppressing apoptosis and ROS production as well as inhibiting DNA damage response in lung cancer cells in a p53-dependent manner.	ros	94-97	cyclin dependent kinase 16	Homo sapiens	34-39
35421237-9	2022	Concomitantly, ME1 absence drives the accumulation of ROS and labile iron.	ros	54-57	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	15-18
29256392-7	2017	Thus, by inhibiting ATGL, HIG2 acts downstream of HIF-1 to sequester FAs in LDs away from the mitochondrial pathways for oxidation and ROS generation, thereby sustaining cancer cell survival in hypoxia.	ros	135-138	patatin like phospholipase domain containing 2	Homo sapiens	20-24
35421237-10	2022	ROS and iron accumulation enhances the susceptibility of ME1 null cells to ferroptosis induction with inhibitors of xCT (erastin and ACXT-3102).	ros	0-3	malic enzyme 1, NADP(+)-dependent, cytosolic	Mus musculus	57-60
28901537-9	2017	Molecularly, we demonstrated that this effect is mediated by activation of Notch1 and Akt and subsequent accumulation of ROS.	ros	121-124	notch 1	Mus musculus	75-81
35455979-5	2022	Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-kappaB; as well as oncogenes, namely RAS and MYC.	ros	78-81	interleukin 1 complex	Mus musculus	154-157
35455979-5	2022	Our results are supported by literature data, particularly the DMBA generated ROS-induced inflammatory and proliferative signal transducers, such as TNF, IL1, IL6, and NF-kappaB; as well as oncogenes, namely RAS and MYC.	ros	78-81	myelocytomatosis oncogene	Mus musculus	216-219
28508718-6	2017	Remarkably, FrA induced caspases- and p53-independent apoptosis, which was characterized by decreased expression of antiapoptotic survivin and Bcl-2, mitochondria targeting (release of cytochrome C, HtrA2/Omi and the apoptosis-inducing factor (AIF), and altered production of ROS) and translocation of AIF to the nuclei.	ros	276-279	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	12-15
35474765-6	2022	Additionally, treatment with NCA resulted in an increased level of total ROS in both cell types (HCT116 and CHEK2-null HCT116 cells), which further confirms that inhibition of PRDX2 results in an increased ROS level, which are mainly responsible for DNA double-strand breaks (DSBs).	ros	73-76	checkpoint kinase 2	Homo sapiens	108-113
35474765-6	2022	Additionally, treatment with NCA resulted in an increased level of total ROS in both cell types (HCT116 and CHEK2-null HCT116 cells), which further confirms that inhibition of PRDX2 results in an increased ROS level, which are mainly responsible for DNA double-strand breaks (DSBs).	ros	206-209	checkpoint kinase 2	Homo sapiens	108-113
35474765-7	2022	ROS-induced DNA DSBs get repaired in HCT116 cells, in which CHEK2 is in the normal functional state, but these DNA DSBs persist in CHEK2-null HCT116 cells as confirmed by the immunofluorescence analysis of 53BP1 and gamma-H2AX.	ros	0-3	checkpoint kinase 2	Homo sapiens	60-65
29186692-6	2017	Upon IR injury, Wnt signaling is specifically activated in Tert+ cells via the ROS-HIFs-transactivated Wnt2b signaling axis.	ros	79-82	telomerase reverse transcriptase	Mus musculus	59-63
35474765-7	2022	ROS-induced DNA DSBs get repaired in HCT116 cells, in which CHEK2 is in the normal functional state, but these DNA DSBs persist in CHEK2-null HCT116 cells as confirmed by the immunofluorescence analysis of 53BP1 and gamma-H2AX.	ros	0-3	checkpoint kinase 2	Homo sapiens	131-136
29186692-6	2017	Upon IR injury, Wnt signaling is specifically activated in Tert+ cells via the ROS-HIFs-transactivated Wnt2b signaling axis.	ros	79-82	wingless-type MMTV integration site family, member 2B	Mus musculus	103-108
35218740-10	2022	Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA.	ros	197-200	Janus kinase 2	Homo sapiens	90-94
34997458-0	2022	Rosuvastatin Alleviates Coronary Microembolization-Induced Cardiac Injury by Suppressing Nox2-Induced ROS Overproduction and Myocardial Apoptosis.	ros	102-105	cytochrome b-245, beta polypeptide	Mus musculus	89-93
28928081-8	2017	In vitro study, Enforced expression of miR-140-5p in HK2 cells significantly attenuated oxidative stress by decreasing ROS level and increasing the expression of manganese superoxide dismutase (MnSOD).	ros	119-122	microRNA 140	Mus musculus	39-46
29209146-9	2017	Restoring ADRM1 protein levels was able to reduce HAP40-induced ROS levels and mitochondrial fragmentation and improved mitochondrial functions and cell viability.	ros	64-67	adhesion regulating molecule 1	Mus musculus	10-15
34997458-10	2022	Rosuvastatin reduced the production of ROS by inhibiting the expression of Nox2.	ros	39-42	cytochrome b-245, beta polypeptide	Mus musculus	75-79
28444875-5	2017	In addition, pre-treatment with the ROS scavenger NAC prevented the MGO-induced down-regulation of p65 and c-FLIPL , and the forced expression of c-FLIPL attenuated MGO-mediated apoptosis.	ros	36-39	synuclein alpha	Homo sapiens	50-53
34997458-12	2022	Rosuvastatin mitigates CME-induced cardiac injury by inhibiting Nox2-induced ROS overproduction and alleviating p53/Bax/Bcl-2-dependent cardiomyocyte apoptosis.	ros	77-80	cytochrome b-245, beta polypeptide	Mus musculus	64-68
35048235-11	2022	For HEI-OC-1 cells, overexpression of full-length p62 decreased ROS levels induced by H2O2.	ros	64-67	sequestosome 1	Mus musculus	50-53
28920425-2	2017	This probe, which is cell permeable and shows high sensitivity and selectivity in fluorometric detection of peroxynitrite over other ROS/RNS, was successfully utilized to detect exogenous and endogenous peroxynitrite in HeLa and RAW 264.7 cells, respectively.	ros	133-136	FAM20C golgi associated secretory pathway kinase	Homo sapiens	137-140
28861175-10	2017	NAC treatment partially reversed the ROS generation and cytotoxic effects induced by pimozide.	ros	37-40	synuclein alpha	Homo sapiens	0-3
35538041-5	2022	Overexpression of H19 could increase cell viability, ATP level and mitochondrial membrane potential, but reduce mitochondrial ROS generation and cell apoptosis ratio in HO-stimulated HEI-OC1 cells.	ros	126-129	H19, imprinted maternally expressed transcript	Mus musculus	18-21
35538041-8	2022	Further experiments demonstrates that H19 regulates HEI-OC1 cell viability, ATP level, mitochondrial membrane potential, mitochondrial ROS generation, and cell apoptosis ratio via the miR-653-5p/SIRT1 axis.	ros	135-138	H19, imprinted maternally expressed transcript	Mus musculus	38-41
35302183-7	2022	NOX4 induces mitochondrial ROS production and HuR downregulation.	ros	27-30	NADPH oxidase 4	Homo sapiens	0-4
35302183-9	2022	Inhibition of NOX4 or SIRT3 overexpression abolished HQ-induced ROS production, thereby abolishing TNF-alpha upregulation.	ros	64-67	NADPH oxidase 4	Homo sapiens	14-18
35302183-10	2022	Overall, these results indicate that SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-alpha upregulation in HQ-treated U937 cells.	ros	121-124	NADPH oxidase 4	Homo sapiens	64-68
29198560-3	2017	And Nf1 deficiency had been reported to lead to ROS overproduction and epithelial-mesenchymal transition (EMT) phenotype.	ros	48-51	neurofibromin 1	Mus musculus	4-7
29198560-4	2017	This study was designed to investigate whether excessive ROS conferred to Nf1 deficiency-induced EMT in Schwann cells.	ros	57-60	neurofibromin 1	Mus musculus	74-77
35341010-7	2022	However, the treatment of LDP impeded the generation of ROS and attenuated renal fibrosis-related proteins in damaged kidneys through interference in the TGF-beta/Smad3 pathway.	ros	56-59	transforming growth factor alpha	Homo sapiens	154-162
28765527-8	2017	These findings suggest that insulin secretion in pancreatic cells is regulated by Ca2+ and ROS signaling through Ca2+-induced structural changes promoting dimerization of hSCGN.	ros	91-94	secretagogin, EF-hand calcium binding protein	Homo sapiens	171-176
28765537-9	2017	The overexpression of PRDX2 inhibits ROS level and myocardial injury after AMI but promotes inflammatory responses in vivo.	ros	37-40	peroxiredoxin 2	Rattus norvegicus	22-27
35341010-7	2022	However, the treatment of LDP impeded the generation of ROS and attenuated renal fibrosis-related proteins in damaged kidneys through interference in the TGF-beta/Smad3 pathway.	ros	56-59	SMAD family member 3	Homo sapiens	163-168
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	16-19	fibroblast growth factor 21	Mus musculus	93-98
28701716-5	2017	Furthermore, we showed that loss of dGLYAT inhibits JNK-mediated ROS production, suggesting dGLYAT regulates multiple functions of JNK signaling in vivo.	ros	65-68	basket	Drosophila melanogaster	52-55
28701716-5	2017	Furthermore, we showed that loss of dGLYAT inhibits JNK-mediated ROS production, suggesting dGLYAT regulates multiple functions of JNK signaling in vivo.	ros	65-68	basket	Drosophila melanogaster	131-134
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	16-19	fibroblast growth factor 21	Mus musculus	152-157
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	24-27	fibroblast growth factor 21	Mus musculus	93-98
28700690-5	2017	Particularly, ROS-related chemicals concomitantly induced intermolecular disulfide crosslinking of human DGAT2.	ros	14-17	diacylglycerol O-acyltransferase 2	Homo sapiens	105-110
35321438-9	2022	Accumulation of ROS and ROS-mediated DNA damage were increased in the liver of Atg7 DeltaHep Fgf21 +/+ mice, which was further aggravated by additional Fgf21 KO probably due to the absence of positive effect of FGF21 on mitochondrial function, explaining the increased number of hepatoma in Atg7 DeltaHep Fgf21 -/- mice compared to Atg7 DeltaHep Fgf21 +/+ mice.	ros	24-27	fibroblast growth factor 21	Mus musculus	152-157
28700690-7	2017	These results clearly demonstrated the significant role of ROS-induced intermolecular crosslinking in the inactivation of human DGAT2 and also suggested DGAT2 as a redox-sensitive regulator in TG biosynthesis.	ros	59-62	diacylglycerol O-acyltransferase 2	Homo sapiens	128-133
28700690-7	2017	These results clearly demonstrated the significant role of ROS-induced intermolecular crosslinking in the inactivation of human DGAT2 and also suggested DGAT2 as a redox-sensitive regulator in TG biosynthesis.	ros	59-62	diacylglycerol O-acyltransferase 2	Homo sapiens	153-158
35414789-0	2022	Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.	ros	62-65	Yes1 associated transcriptional regulator	Homo sapiens	0-3
28342843-0	2017	The stress-response molecule NR4A1 resists ROS-induced pancreatic beta-cells apoptosis via WT1.	ros	43-46	nuclear receptor subfamily 4, group A, member 1	Mus musculus	29-34
28342843-0	2017	The stress-response molecule NR4A1 resists ROS-induced pancreatic beta-cells apoptosis via WT1.	ros	43-46	WT1 transcription factor	Mus musculus	91-94
32203922-11	2020	Together, these findings demonstrate that HLH-2 regulates energy metabolism via arginine kinases and thereby affects the aging phenotype dependent on ROS-signaling and established canonical effectors.	ros	150-153	Helix-loop-helix protein hlh-2	Caenorhabditis elegans	42-47
28342843-3	2017	However, It remains unknown whether NR4A1 is able to protect pancreatic beta-cells against ROS-associated oxidative stress.	ros	91-94	nuclear receptor subfamily 4, group A, member 1	Mus musculus	36-41
35414789-0	2022	Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.	ros	62-65	bone morphogenetic protein 2	Homo sapiens	89-93
32398966-12	2020	Cilostazol also inhibited the ROS accumulation and the activation of p38MAPK and JNK, which providing novel connection between lysosome CTSB and ROS/p38MAPK/JNK related oxidative stress pathway.	ros	145-148	cathepsin B	Rattus norvegicus	136-140
32398966-12	2020	Cilostazol also inhibited the ROS accumulation and the activation of p38MAPK and JNK, which providing novel connection between lysosome CTSB and ROS/p38MAPK/JNK related oxidative stress pathway.	ros	145-148	mitogen-activated protein kinase 8	Rattus norvegicus	157-160
35414789-6	2022	Furthermore, inactivation of Yap resulted in an obvious accumulation of intracellular ROS followed by the abnormal GR activity and GSH content dependent on Rrm2.	ros	86-89	Yes1 associated transcriptional regulator	Homo sapiens	29-32
35414789-7	2022	Replenishment of GSH counteracted the regulation of Yap inactivation on stromal differentiation and DNA damage with distinct reduction for intracellular ROS.	ros	153-156	Yes1 associated transcriptional regulator	Homo sapiens	52-55
35414789-10	2022	Collectively, Yap was essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.	ros	77-80	Yes1 associated transcriptional regulator	Homo sapiens	14-17
32368147-11	2020	Moreover, DLX6-AS1 knockdown suppressed TRPC3-mediated mitochondrial calcium uptake and ROS production.	ros	88-91	distal-less homeobox 6	Homo sapiens	10-14
28384544-2	2017	Systematic structure-activity relationship study revealed that hydroxyl group in C-5, C-6, or C-7 position of indanone moiety, and ortho-, meta-, or para-fluorine, trifluoromethyl, trifluoromethoxy, and bromine functionalities in phenyl ring are important for inhibition of ROS production in LPS-stimulated RAW 264.7 macrophages.	ros	274-277	complement C5	Homo sapiens	81-84
35414789-10	2022	Collectively, Yap was essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.	ros	77-80	bone morphogenetic protein 2	Homo sapiens	104-108
35051861-16	2022	Activating PPARgamma plays a protective role in AGEs-induced impairment of coronary artery vasodilation by inhibiting p38 phosphorylation to attenuate NOX2 and p22phox expression and further decrease oxidative stress induced by ROS overproduction.	ros	228-231	mitogen activated protein kinase 14	Rattus norvegicus	118-121
28642708-7	2017	Further mechanistic investigation revealed that 17-AAG, a pharmacologic inhibitor of Hsp90, significantly blocked the myricitrin-induced cardioprotective effect demonstrated by increased apoptosis and ROS generation.	ros	201-204	heat shock protein 90 alpha family class A member 1	Homo sapiens	85-90
35123993-9	2022	Conclusively, our results indicated that HQ toxicity is mediated by AhR which is in turn regulated by ROS generated by HQ.	ros	102-105	aryl hydrocarbon receptor	Homo sapiens	68-71
28423723-7	2017	HKL-mediated activation of SIRT3 prevented Doxorubicin induced ROS production, mitochondrial damage and cell death in rat neonatal cardiomyocytes.	ros	63-66	sirtuin 3	Rattus norvegicus	27-32
28545052-0	2017	BRL3 and AtRGS1 cooperate to fine tune growth inhibition and ROS activation.	ros	61-64	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	9-15
35123993-10	2022	The interaction between AhR and ROS drive and amplify the hematopoietic toxicity of HQ.	ros	32-35	aryl hydrocarbon receptor	Homo sapiens	24-27
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	43-46	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	9-15
35149217-6	2022	Further investigation verified that NADPH oxidase 2 (NOX2) and mitochondria are two prominent sources of PM2.5-induced ROS production in vascular macrophages.	ros	119-122	cytochrome b-245, beta polypeptide	Mus musculus	36-51
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	9-15
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	9-15
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	9-15
28545052-7	2017	BRL3 and AtRGS1 modulate the flg22-induced ROS burst and block one or more components positively regulating ROS production because the brl3/rgs1 double mutant has ~60% more ROS production than wild type while rgs1-2 has a partial ROS burst impairment and brl3 has slightly more ROS production.	ros	108-111	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	9-15
35149217-6	2022	Further investigation verified that NADPH oxidase 2 (NOX2) and mitochondria are two prominent sources of PM2.5-induced ROS production in vascular macrophages.	ros	119-122	cytochrome b-245, beta polypeptide	Mus musculus	53-57
28881661-8	2017	Through inducing ROS-mediated degradation of Mcl-1 ubiquitination, the triple combination of 5-FU, DTN and DHA resulted in the elevated apoptosis in CRC cells, thus to reduce the tumor size and weight.	ros	17-20	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	45-50
35227235-4	2022	The SAT1 activation is closely related to ferroptosis upon ROS induction due to the upregulation of arachidonate 15-lipoxygenase (ALOX15) expression.	ros	59-62	spermidine/spermine N1-acetyltransferase 1	Homo sapiens	4-8
35196483-4	2022	The ROS-dependent TRAF6-mediated non-proteolytic, K48/63-linked ubiquitination of ATG9A enhances its association with Beclin 1 and the assembly of VPS34-UVRAG complex, thereby stimulating autophagy.	ros	4-7	autophagy related 9A	Homo sapiens	82-87
35196483-4	2022	The ROS-dependent TRAF6-mediated non-proteolytic, K48/63-linked ubiquitination of ATG9A enhances its association with Beclin 1 and the assembly of VPS34-UVRAG complex, thereby stimulating autophagy.	ros	4-7	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	147-152
28366735-8	2017	By this way, rgs-1 mutant worms exhibited lower ROS damage and longer survival time than wild type worms when both exposed to paraquat.	ros	48-51	RGS domain-containing protein;Regulator of G-protein signaling rgs-1	Caenorhabditis elegans	13-18
35196483-5	2022	Notably, expression of the ATG9A ubiquitination mutants impairs ROS-induced VPS34 activation and autophagy.	ros	64-67	autophagy related 9A	Homo sapiens	27-32
35196483-5	2022	Notably, expression of the ATG9A ubiquitination mutants impairs ROS-induced VPS34 activation and autophagy.	ros	64-67	phosphatidylinositol 3-kinase catalytic subunit type 3	Homo sapiens	76-81
35196483-6	2022	We further find that lipopolysaccharide (LPS)-induced ROS production also stimulates TRAF6-mediated ATG9A ubiquitination.	ros	54-57	autophagy related 9A	Homo sapiens	100-105
35136019-5	2022	MHY1485-induced hyperactivation of mTORC1 during this period resulted in a significant increase in the overall size of ROs compared to the untreated controls and rapamycin-treated Ros; there was also a marked increase in proliferative activity within the inner and outer layers of ROs.	ros	119-122	CREB regulated transcription coactivator 1	Mus musculus	35-41
28211011-7	2017	Additionally, an antioxidant NAC attenuated the TEOA-induced mitophagy, indicating that TEOA triggers mitophagy via a ROS-dependent pathway.	ros	118-121	synuclein alpha	Homo sapiens	29-32
35136019-5	2022	MHY1485-induced hyperactivation of mTORC1 during this period resulted in a significant increase in the overall size of ROs compared to the untreated controls and rapamycin-treated Ros; there was also a marked increase in proliferative activity within the inner and outer layers of ROs.	ros	180-183	CREB regulated transcription coactivator 1	Mus musculus	35-41
35136019-5	2022	MHY1485-induced hyperactivation of mTORC1 during this period resulted in a significant increase in the overall size of ROs compared to the untreated controls and rapamycin-treated Ros; there was also a marked increase in proliferative activity within the inner and outer layers of ROs.	ros	281-284	CREB regulated transcription coactivator 1	Mus musculus	35-41
34847081-7	2022	ISG15-/- fibroblasts exhibited elevated ROS levels and reduced ROS scavenger expression.	ros	40-43	ISG15 ubiquitin like modifier	Homo sapiens	0-5
34847081-7	2022	ISG15-/- fibroblasts exhibited elevated ROS levels and reduced ROS scavenger expression.	ros	63-66	ISG15 ubiquitin like modifier	Homo sapiens	0-5
35039634-0	2022	ROS-regulated phosphorylation of ITPKB by CAMK2G drives cisplatin resistance in ovarian cancer.	ros	0-3	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	42-48
35039634-5	2022	Mechanistically, CAMK2G directly senses ROS, both basal and cisplatin-induced, to control the phosphorylation of ITPKB at serine 174, which directly regulates ITPKB activity to modulate cisplatin-induced ROS stress.	ros	40-43	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	17-23
35043976-5	2022	Such improved immunotherapy response by MCT4 targeting was due to combined consequences, characterized by the alleviated acidification of tumor microenvironment (TME) and elevated the CXCL9/CXCL10 secretion induced by ROS/NF-kappaB signaling pathway.	ros	218-221	solute carrier family 16 (monocarboxylic acid transporters), member 3	Mus musculus	40-44
3136032-4	1988	In this paper, using a convenient, non-invasive light scattering assay, we demonstrate that in an intact stack of disks, where active transducin stays membrane associated and is rapidly deactivated, the activity of rhodopsin can also be quenched in the time range of seconds when soluble ROS proteins are supplemented.	ros	288-291	rhodopsin	Bos taurus	215-224
28282037-5	2017	High-resolution respirometry revealed a reduction in mitochondrial respiration and complex I activity upon pharmacological activation and overexpression of mitochondrial SK2 channels resulting in reduced mitochondrial ROS formation.	ros	218-221	potassium calcium-activated channel subfamily N member 2	Homo sapiens	170-173
27928873-8	2017	CONCLUSION: Lycopene inhibits RCAN1-mediated apoptosis by reducing ROS levels and by inhibiting NF-kappaB activation, Nucling induction, and the increase in apoptotic indices in neuronal cells.	ros	67-70	regulator of calcineurin 1	Homo sapiens	30-35
28235484-7	2017	BCAT1 can promote mitochondrial biogenesis, ATP production and repress mitochondrial ROS in breast cancer cells by regulating the expression of related genes.	ros	85-88	branched chain amino acid transaminase 1	Homo sapiens	0-5
28431562-13	2017	Aldh2 -/- tracheal and lung cells showed higher ROS levels and fewer functional mitochondria than those from WT mice.	ros	48-51	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	0-5
28881620-5	2017	Importantly, the relative mechanisms were associated with reduced GRP78-Src interaction and ROS production, and subsequently reduced RhoA/ROCK activation, and eventually decreased VE-cadherin and myosin light chain (MLC) phosphorylation.	ros	92-95	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	196-214
28417940-6	2017	The extract increased ROS production in HepG2 cells, which resulted in decreased GSH level, leading to apoptosis of these cells through activation of caspase-3 and caspase-7.	ros	22-25	caspase 7	Homo sapiens	164-173
27912197-9	2017	The inhibition of Rac1 by NSC23766 inhibited NADPH oxidase activity and ROS generation induced by high glucose concentrations in INS-1 &amp; human 1.1b4 beta cells.	ros	72-75	insulin 1	Rattus norvegicus	129-134
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	ros	49-52	protein tyrosine kinase 2 beta	Homo sapiens	212-216
28245869-10	2017	Mechanistically, glutamine deprivation increases intracellular ROS levels, leading to down-regulation of the beta-catenin pathway.	ros	63-66	catenin beta 1	Homo sapiens	109-121
27890624-3	2017	In the present work we report a network among OPA1, Sirt3 and cAMP in ROS-dependent apoptosis.	ros	70-73	sirtuin 3	Rattus norvegicus	52-57
27890624-8	2017	Using H89, inhibitor of the protein kinase A (PKA), and protease inhibitors, evidences have been obtained that ROS-dependent apoptosis is associated with an alteration of mitochondrial cAMP/PKA signal that causes degradation/proteolysis of Sirt3 that, in turn, promotes acetylation and proteolytic processing of OPA1.	ros	111-114	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	28-44
27654302-7	2017	Meanwhile, fucoidan treatment increased the generation of intracellular ROS, whereas the over-elimination of ROS by N-acetylcysteine, an anti-oxidant, attenuated fucoidan-induced apoptosis, inhibition of hTERT, c-myc, and Sp1 expression, and reversed fucoidan-induced inactivation of the PI3K/Akt signaling pathway.	ros	109-112	telomerase reverse transcriptase	Homo sapiens	204-209
27654302-7	2017	Meanwhile, fucoidan treatment increased the generation of intracellular ROS, whereas the over-elimination of ROS by N-acetylcysteine, an anti-oxidant, attenuated fucoidan-induced apoptosis, inhibition of hTERT, c-myc, and Sp1 expression, and reversed fucoidan-induced inactivation of the PI3K/Akt signaling pathway.	ros	109-112	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	211-216
28139737-6	2017	These results establish a novel mechanism by which NF-kappaB and Akt contribute to chemoresistance involving a signaling pathway consisting of histone H4, DNA-PK, RIP1 and IAPs that attenuates ROS-mediated apoptosis, and targeting this pathway may improve the anticancer efficacy of platinum-based chemotherapy.	ros	193-196	receptor interacting serine/threonine kinase 1	Homo sapiens	163-167
28102348-0	2017	HO-1 inhibits preadipocyte proliferation and differentiation at the onset of obesity via ROS dependent activation of Akt2.	ros	89-92	thymoma viral proto-oncogene 2	Mus musculus	117-121
28102348-6	2017	Mechanistically, HO-1 reduces HFD-induced AKT2 phosphorylation via ROS thresholding in mitochondria to reduce visceral adipose precursor proliferation.	ros	67-70	thymoma viral proto-oncogene 2	Mus musculus	42-46
28102348-9	2017	This collectively renders HO-1 as an essential factor linking extrinsic factors (HFD) with inhibition of specific downstream molecular mediators (ROS &amp;AKT2), resulting in diminished adipogenesis that may contribute to hyperplastic adipose tissue expansion.	ros	146-149	thymoma viral proto-oncogene 2	Mus musculus	155-159
29035891-9	2017	Furthermore, NAC, a ROS scavenger, abrogated the effects of salidroside on TFEB-dependent autophagy.	ros	20-23	synuclein alpha	Homo sapiens	13-16
27878299-5	2017	CSE increased the ability of myocardial tissue to scavenge free radicals, inhibited lipid peroxidation, increased recovery activity of antioxidant enzymes, adjusted the energy metabolism of myocardial tissue, inhibited the generation of a large number of ROS in the cells, raised the level of Deltapsim, and improved the metabolism of free radicals.	ros	255-258	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	0-3
28694915-6	2017	Overall, our study is the first to demonstrate that the cytoprotective actions of halophenols involve their antiapoptotic, antioxidant, and anti-inflammatory abilities, which are mediated by the upregulation of Nrf2-dependent HO-1 expression and reductions in ROS and TNF-alpha generation via the activation of Erk1/2 and PI3K/Akt in EA.hy926 cells.	ros	260-263	heme oxygenase 1	Homo sapiens	226-230
29147462-5	2017	Consequently, ROS induced by 20% O2 caused DNA damage and then activated p53-p21-Rb and p16-Rb pathways via ERK signaling to induce NP cell senescence.	ros	14-17	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	73-76
27863045-3	2016	The fluorescence of the probe was quenched by 2-chloro and 6-phenyl selenium groups; the probe shows high selectivity with NaOCl among other ROS/RNS, and gives a turn-on response.	ros	141-144	FAM20C golgi associated secretory pathway kinase	Homo sapiens	145-148
27863045-4	2016	The maximum fluorescence intensity is attained within  1-2 min with a low detection limit (19.6 nm), and shows a  110-fold fluorescence enhancement compared to signals generated for other ROS/RNS.	ros	188-191	FAM20C golgi associated secretory pathway kinase	Homo sapiens	192-195
27974211-4	2016	Ablating both Shp2 and Pten in hepatocytes induced early-onset non-alcoholic steatohepatitis (NASH) and promoted genesis of liver tumor-initiating cells likely due to augmented cJun expression/activation and elevated ROS and inflammation in the hepatic microenvironment.	ros	217-220	phosphatase and tensin homolog	Homo sapiens	23-27
27793052-5	2016	Finally, we confirmed that ROS scavenging was responsible for Andrographolide"s inactivation of NF-kappaB and NLRP3 inflammasome signaling.	ros	27-30	NLR family, pyrin domain containing 3	Mus musculus	110-115
27705915-2	2016	Previous studies showed that LKB1 participates in IR- and ROS-induced DNA damage response (DDR).	ros	58-61	serine/threonine kinase 11	Homo sapiens	29-33
27565029-11	2016	Moreover, AngII and miR-106a treatment cultured cardiomyocytes mitochondria presented cristae defects, considerable depolarization of mitochondrial membrane and increased ROS production.	ros	171-174	microRNA 106a	Homo sapiens	20-28
27484784-0	2016	Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.	ros	201-204	DNA-damage inducible transcript 3	Rattus norvegicus	72-76
27620507-3	2016	CLP induced alterations in kidney function and morphology were associated with SIRT3 downregulation, and SIRT3 deletion exacerbated CLP-induced kidney dysfunction, renal tubular cell injury and apoptosis, mitochondrial alterations, and ROS production in a knockout mouse model.	ros	236-239	sirtuin 3	Mus musculus	105-110
27620507-5	2016	Our results suggest that SIRT3 plays a protective role against mitochondrial damage in the kidney by attenuating ROS production, inhibiting the NRLP3 inflammasome, attenuating oxidative stress, and downregulating IL-1beta and IL-18.	ros	113-116	sirtuin 3	Mus musculus	25-30
27497919-3	2016	And the increase of reactive oxidative species (ROS) production, the upregulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) and vascular endothelial growth factor (VEGF) protein induced by high glucose were antagonized by Sal B.	ros	48-51	vascular endothelial growth factor A	Rattus norvegicus	135-169
27582555-10	2016	In addition, ROS scavengers suppressed other oxidative enzymes such as catalase (CAT), glutathione S-transferase (GST), and NADH quinone oxidoreductase (NQO-1) in IK-treated RAW264.7 cells.	ros	13-16	hematopoietic prostaglandin D synthase	Mus musculus	87-112
27582555-10	2016	In addition, ROS scavengers suppressed other oxidative enzymes such as catalase (CAT), glutathione S-transferase (GST), and NADH quinone oxidoreductase (NQO-1) in IK-treated RAW264.7 cells.	ros	13-16	hematopoietic prostaglandin D synthase	Mus musculus	114-117
27582555-10	2016	In addition, ROS scavengers suppressed other oxidative enzymes such as catalase (CAT), glutathione S-transferase (GST), and NADH quinone oxidoreductase (NQO-1) in IK-treated RAW264.7 cells.	ros	13-16	crystallin, zeta	Mus musculus	129-151
27414741-6	2016	Interestingly, NAC, a ROS inhibitor, inhibited p53 expression, and decreased the apoptosis of HAPI microglia.	ros	22-25	synuclein alpha	Homo sapiens	15-18
27431331-8	2016	Furthermore, the abrogation of cellular MyD88 expression by ST2825 eliminated the inhibitory effect of dioscin on the levels of nuclear NF-kappaB, cleaved caspase-3, SOD2 and ROS.	ros	175-178	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	40-45
27281219-0	2016	Corrigendum: Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1.	ros	27-30	uncoupling protein 1	Homo sapiens	92-96
27642560-6	2016	These results show that H2O2 is capable of activating ROS-CyPA-p38 MAPK interactions to enhance HCMV replication.	ros	54-57	peptidylprolyl isomerase A	Homo sapiens	58-62
27513743-0	2016	Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity.	ros	111-114	signal transducer and activator of transcription 5A	Homo sapiens	28-33
27540389-8	2016	Virus-induced gene silencing-mediated silencing of SlTPS3, SlTPS4, or SlTPS7 led to deregulation of ROS accumulation and attenuated the expression of defense-related genes upon pathogen infection and thus deteriorated the resistance against B. cinerea or Pst DC3000.	ros	100-103	beta-phellandrene/beta-myrcene/sabinene synthase	Solanum lycopersicum	59-65
27393003-2	2016	Peroxiredoxin-3 (Prx-3), a mitochondrial antioxidant, scavenges H2O2 and offers protection against ROS related pathologies.	ros	99-102	peroxiredoxin 3	Rattus norvegicus	0-15
27393003-2	2016	Peroxiredoxin-3 (Prx-3), a mitochondrial antioxidant, scavenges H2O2 and offers protection against ROS related pathologies.	ros	99-102	peroxiredoxin 3	Rattus norvegicus	17-22
26773873-10	2016	RTA 408 pretreatment significantly protected cells from oxidative stress-induced GSH loss, GSSG formation and decreased ROS production.	ros	120-123	MAS related GPR family member F	Homo sapiens	0-3
26795735-8	2016	TrxR was shown to regulate HO-1 via the Nrf2 signaling pathway in a ROS-dependent manner.	ros	68-71	peroxiredoxin 5	Homo sapiens	0-4
26795735-8	2016	TrxR was shown to regulate HO-1 via the Nrf2 signaling pathway in a ROS-dependent manner.	ros	68-71	heme oxygenase 1	Homo sapiens	27-31
27251440-0	2016	Quinones Derived from Polychlorinated Biphenyls Induce ROS-Dependent Autophagy by Evoking an Autophagic Flux and Inhibition of mTOR/p70S6k.	ros	55-58	ribosomal protein S6 kinase B1	Homo sapiens	132-138
27286259-8	2016	Further, TLR4 activation in primary human lung cancer cells increased their ROS levels.	ros	76-79	toll like receptor 4	Homo sapiens	9-13
27286259-9	2016	Scavenge of ROS abrogated the up-regulation of miR-21 in primary human lung cancer cells and attenuated LPS-induced outgrowth.	ros	12-15	microRNA 21	Homo sapiens	47-53
27286259-10	2016	For in vivo relevance, expression of TLR4 was correlated with miR-21 expression and ROS production in freshly isolated, untreated primary human lung cancer cells.	ros	84-87	toll like receptor 4	Homo sapiens	37-41
27286259-11	2016	These findings demonstrate an essential role of TLR4/ROS/miR-21 pathway in LPS-induced outgrowth of primary human lung cancer.	ros	53-56	microRNA 21	Homo sapiens	57-63
29468124-5	2016	We demonstrate how Hap1p can activate a set of oxidative stress response genes and meanwhile contribute to increase the metabolic rate of the yeast strains, therefore mitigating the negative effect of the ROS accumulation associated to protein folding and hence increasing the production capacity during batch fermentations.	ros	205-208	Hap1p	Saccharomyces cerevisiae S288C	19-24
27250627-12	2016	Anti-dsDNA Abs bound to TLR4 on macrophages and induced the production of ROS.	ros	74-77	toll like receptor 4	Homo sapiens	24-28
26946493-0	2016	Loss of IkappaB kinase beta promotes myofibroblast transformation and senescence through activation of the ROS-TGFbeta autocrine loop.	ros	107-110	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	8-27
26946493-2	2016	We show that in vitro ablation of Ikkbeta in fibroblasts led to progressive ROS accumulation and TGFbeta activation, and ultimately accelerated cell migration, fibroblast-myofibroblast transformation and senescence.	ros	76-79	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	34-41
26946493-4	2016	Lacking this activity, IKKbeta-null cells showed ROS accumulation and activation of stress-sensitive transcription factor AP-1/c-Jun.	ros	49-52	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	23-30
26946493-6	2016	These data suggest that by blocking the autocrine amplification of a ROS-TGFbeta loop IKKbeta plays a crucial role in the prevention of fibroblast-myofibroblast transformation and senescence.	ros	69-72	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	86-93
26801320-2	2016	In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation.	ros	157-160	heme oxygenase 1	Homo sapiens	68-84
26801320-2	2016	In this research we proved that cisplatin induced cell injuries and heme oxygenase-1 (HO-1) expression in laryngeal squamous cell cancer Hep-2 cells through ROS generation.	ros	157-160	heme oxygenase 1	Homo sapiens	86-90
26801320-3	2016	The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin.	ros	90-93	heme oxygenase 1	Homo sapiens	17-21
26801320-3	2016	The induction of HO-1 clearly protected Hep-2 cells from cisplatin-induced cell death and ROS reaction, and the inhibitor of HO-1 enhanced the cell death and ROS generation induced by cisplatin.	ros	158-161	heme oxygenase 1	Homo sapiens	125-129
26850986-8	2016	Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels, and NAC could attenuate necroptotic cell death, indicating that the periplogenin-induced necroptotic cell death was mediated by oxidative stress.	ros	17-20	proprotein convertase subtilisin/kexin type 1	Homo sapiens	102-107
26850986-8	2016	Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels, and NAC could attenuate necroptotic cell death, indicating that the periplogenin-induced necroptotic cell death was mediated by oxidative stress.	ros	126-129	proprotein convertase subtilisin/kexin type 1	Homo sapiens	102-107
26921636-7	2016	Importantly, cholesterol was found to inhibit the activity of AMPKalpha in macrophages, leading to a significant production of mitochondrial ROS, which in turn activated the NLRP3 inflammasome.	ros	141-144	NLR family, pyrin domain containing 3	Mus musculus	174-179
26860957-5	2016	The increase in levels of inflammatory cytokines/chemokines corresponds to increased levels of ROS/RNS, which is accompanied by increased activities of Akt, ERK1/2, tuberin, down regulation of 8-oxoG-DNA glycosylase (OGG1), and increase in 8-hydroxydeoxyguanosine (8-OHdG) accumulation in DNA.	ros	95-98	TSC complex subunit 2	Mus musculus	165-172
26906415-5	2016	In cells where RECQL4 does not localize to mitochondria, the membrane potential was decreased, whereas ROS levels increased due to the presence of high levels of catalytically inactive SOD2.	ros	103-106	RecQ like helicase 4	Homo sapiens	15-21
27000859-7	2016	G2/M arrest was attenuated by the addition of ROS scavenger NAC.	ros	46-49	synuclein alpha	Homo sapiens	60-63
26775629-8	2016	In BCC/KMC1 cells, the induction of p53 by IMQ was achieved through increased ROS production to stimulate the ATM/ATR-Chk1/Chk2 axis but was not mediated by inducing DNA damage.	ros	78-81	ATM serine/threonine kinase	Homo sapiens	110-113
26796279-14	2016	Inhibition of NFkappaB activity as well as suppression of ROS generation with NAC resulted in the partial relief of cells from G2/M checkpoint after curcumin treatment in wt MCF-7 cells.	ros	58-61	synuclein alpha	Homo sapiens	78-81
26566260-13	2016	Cytokine secretion was also regulated by ROS, which were attenuated by TMZ via activation of Sirt1, AMPK and PPARalpha.	ros	41-44	sirtuin 1	Mus musculus	93-98
26621818-4	2016	Using an in vitro model of GAS-infected keratinocytes, we show that the major ROS produced is the superoxide anion ([Formula: see text]), and that its production is time- and dose-dependent.	ros	78-81	gastrin	Homo sapiens	27-30
26621818-7	2016	In conclusion, GAS-stimulated keratinocytes are able to develop an innate immune response based on the production of ROS.	ros	117-120	gastrin	Homo sapiens	15-18
26721440-5	2016	Further analysis with iTraq identified CYP1B1, a component of the cytochrome p450 system, as a potential molecule mediating ROS generation in pNO40 deficient MSCs.	ros	124-127	zinc finger, CCHC domain containing 17	Mus musculus	142-147
26902406-15	2016	In this study apoptosis induction by Lanatoside C was characterized through ROS altered ERK and Akt pathways in both PTEN adequate epithelial and deficient mesenchymal liver cancer cells.	ros	76-79	phosphatase and tensin homolog	Homo sapiens	117-121
26672619-6	2016	In addition, the accumulation of ROS was detected in Rh2-O-treated HepG2 cells, which participated in the apoptosis of HepG2 cells.	ros	33-36	Rh associated glycoprotein	Homo sapiens	53-58
28959532-7	2016	We hypothesize that Mel may be scavenging reactive species of oxygen (ROS) that could be damaging lipids, PEPCK, G6Pase and ferrochelatase (FQ).	ros	70-73	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	113-119
26276860-6	2016	Trx1 overexpression and small interfering RNA knockdown in cells revealed that reduced Trx1 after exposure to lower doses of MMS attenuated DNA damage, assessed by comet assay, and level of the DNA-damage marker histone gamma-H2AX, possibly through scavenging intracellular ROS and an increase in p21 protein level via enhancing its stability.	ros	274-277	thioredoxin	Homo sapiens	87-91
27433030-6	2016	These findings suggest that XO may be a potential target of HSYA via direct binding inhibition and the combination of HSYA-XO suppresses LPS-induced ROS generation, contributing to the depression of NLRP3 inflammasome and inhibition of IL-1beta secretion in macrophages.	ros	149-152	NLR family, pyrin domain containing 3	Mus musculus	199-204
26770648-11	2016	Knocking-down UCP3 by siRNA prevented WY-14643 from attenuating the production of ROS.	ros	82-85	uncoupling protein 3	Rattus norvegicus	14-18
27891207-8	2016	These results reveal that GAS has the cytoprotection in HepG2 cells during ROS exposure by inhibiting the caspase activity in the mitochondria and influencing apoptogenic factors of the expression of Bax and Bcl-2.	ros	75-78	gastrin	Homo sapiens	26-29
26335193-12	2015	Collectively, our findings provide the first evidence that cotreatment with free or liposomal chrysophsin-1 and epirubicin leads to cell death in human cervical cancer cells through the ROS-mediated inhibition of P-gp and MRPs and concerted activation of mitochondrial apoptosis pathway.	ros	186-189	phosphoglycolate phosphatase	Homo sapiens	213-217
26549478-6	2015	ROS scavenger (N-acetyl cysteine, NAC) could attenuate both the resveratrol induced caspase-3 activity and the formation of acidic vacuoles, but failed to attenuate resveratrol induced PEL cell death.	ros	0-3	synuclein alpha	Homo sapiens	34-37
26456051-0	2015	SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells.	ros	185-188	inositol polyphosphate phosphatase like 1	Homo sapiens	46-51
26456051-5	2015	Overexpression of the SHIP2-DN decreased high glucose-induced apoB containing lipoproteins secretion via reduction in ROS generation, JNK phosphorylation and Akt activation.	ros	118-121	inositol polyphosphate phosphatase like 1	Homo sapiens	22-30
26453893-8	2015	Furthermore, NAC reduced DNA migration, ROS formation, GSH depletion and the expression of the p53 protein and gene.	ros	40-43	synuclein alpha	Homo sapiens	13-16
26823733-10	2015	Our data suggested the decrease of HOTAIR expression led to ROS related defects in sperm function.	ros	60-63	HOX transcript antisense RNA	Homo sapiens	35-41
26437801-7	2015	Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFalpha in an ATP7A-independent manner.	ros	121-124	neutrophil cytosolic factor 1	Mus musculus	93-100
26437801-7	2015	Moreover, Atox1 functions as a Cu-dependent transcription factor for NADPH oxidase organizer p47phox, thereby increasing ROS-NFkappaB-VCAM-1/ICAM-1 expression and monocyte adhesion in ECs inflamed with TNFalpha in an ATP7A-independent manner.	ros	121-124	vascular cell adhesion molecule 1	Mus musculus	134-140
26165189-6	2015	A ROS inducer, antimycin A, caused an increase in both the number and size of the mitochondrial M-LPH foci, and these foci were co-localized with two enzymes, DNA polymerase gamma (POLG) and DNA ligase III (LIG3), both involved in mtDNA repair.	ros	2-5	DNA polymerase gamma, catalytic subunit	Homo sapiens	181-185
26165189-6	2015	A ROS inducer, antimycin A, caused an increase in both the number and size of the mitochondrial M-LPH foci, and these foci were co-localized with two enzymes, DNA polymerase gamma (POLG) and DNA ligase III (LIG3), both involved in mtDNA repair.	ros	2-5	DNA ligase 3	Homo sapiens	191-205
26165189-6	2015	A ROS inducer, antimycin A, caused an increase in both the number and size of the mitochondrial M-LPH foci, and these foci were co-localized with two enzymes, DNA polymerase gamma (POLG) and DNA ligase III (LIG3), both involved in mtDNA repair.	ros	2-5	DNA ligase 3	Homo sapiens	207-211
26070526-8	2015	Our data indicated that propofol down-regulated PP2A expression, leading to reduced dephosphorylation of p66(Shc)-Ser(36) and eNOS-Ser(1177), which is associated with ROS accumulation and NO reduction, resulting in inhibition of endothelial adhesion molecule expression and mononuclear-endothelial interaction.	ros	167-170	protein phosphatase 2 phosphatase activator	Homo sapiens	48-52
26070526-8	2015	Our data indicated that propofol down-regulated PP2A expression, leading to reduced dephosphorylation of p66(Shc)-Ser(36) and eNOS-Ser(1177), which is associated with ROS accumulation and NO reduction, resulting in inhibition of endothelial adhesion molecule expression and mononuclear-endothelial interaction.	ros	167-170	DNA polymerase delta 3, accessory subunit	Homo sapiens	105-108
26253469-4	2015	Our data indicated that different magnitudes and chronicities of ROS levels in cardiomyocytes resulted in differential expression of miR-1, subsequently altering the expression of myocardin.	ros	65-68	fibronectin type III and SPRY domain containing 1	Homo sapiens	133-138
26197244-8	2015	Severe apoptosis of cells in the head, heart and tail region with inhibition of catalase confirms ROS induced acute toxicity with increasing concentration.	ros	98-101	catalase	Danio rerio	80-88
26117230-5	2015	Moreover, we identified the functions of transduced PEP-1-PON1 proteins which include, mitigating mitochondrial damage, decreasing reactive oxidative species (ROS) production, matrix metalloproteinase-9 (MMP-9) expression and protecting against 1-methyl-4-phenylpyridinium (MPP(+))-induced neurotoxicity in SH-SY5Y cells.	ros	159-162	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	52-57
26062875-7	2015	We conclude that the p67(phox) subunit of NADPH oxidase 2 plays an important role in the excess production of ROS from mitochondria in the renal medulla of the SS rat.	ros	110-113	methionyl aminopeptidase 2	Rattus norvegicus	21-24
26117405-7	2015	The overexpression of miR-19b-3p, miR-221-3p and miR-222-3p in HAECs caused intracellular ROS accumulation, which led to cellular apoptosis.	ros	90-93	microRNA 19b-1	Homo sapiens	22-29
25204891-11	2015	Silencing of ASK1 resulted in significant attenuation of JNK activation as well as reversed the hesperetin-mediated apoptosis suggesting that hesperetin-mediated apoptosis of MCF-7 cells involves accumulation of ROS and activation of ASK1/JNK pathway.	ros	212-215	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	13-17
26226833-0	2015	FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus.	ros	4-7	transformation related protein 53, pseudogene	Mus musculus	8-11
25764979-10	2015	Overexpression of MIC26 induced fragmentation of mitochondria, promoted ROS formation and resulted in impaired mitochondrial respiration.	ros	72-75	apolipoprotein O	Homo sapiens	18-23
25712449-9	2015	PDGF-D is endogenous, generates ROS via the mitochondrial electron transport system, and regulates the autocrine loop of ASCs in vivo.	ros	32-35	platelet derived growth factor D	Homo sapiens	0-6
25796140-5	2015	HIF1alpha and HIF2alpha contribute to important adaptive mechanisms that occur when oxygen and ROS homeostasis become unbalanced.	ros	95-98	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-9
25796140-5	2015	HIF1alpha and HIF2alpha contribute to important adaptive mechanisms that occur when oxygen and ROS homeostasis become unbalanced.	ros	95-98	endothelial PAS domain protein 1	Mus musculus	14-23
25868872-5	2015	However, our simulation results predict that, when cytochrome c oxidase is inhibited during oxidation of succinate, ROS production at this site is eliminated and almost all superoxide in Complex I is generated by reduced FMN, even when the redox pressure for reverse electron transfer from succinate is strong.	ros	116-119	formin 1	Homo sapiens	221-224
26078725-10	2015	ROS scavenger N-acetyl-L-cysteine (NAC) blocked the autophagy process induced by 5cGy alpha particle, the upregulation of Nrf2 and HO-1, as well as the induced radio-resistance.	ros	0-3	heme oxygenase 1	Homo sapiens	131-135
26078725-11	2015	In conclusion, ROS elevation caused by LDIR promoted Autophagy/Nrf2-HO-1 and conferred radio-resistance in A549.	ros	15-18	heme oxygenase 1	Homo sapiens	68-72
33194315-4	2020	In cell experiments, slow-releasing poly(EDP-NAC) rescued H9C2 cardiomyocytes more effectively than EDP-NAC when cells were treated with 5-fluorouricil (5-FU), which induces sustained production of ROS.	ros	198-201	synuclein alpha	Homo sapiens	45-48
32312970-6	2020	Furthermore, Drp1 mediated metabolic disorders and inhibited the levels of mitochondrial glutathione to impair free radical scavenging, leading to further increases in ROS and the exacerbation of mitochondrial dysfunction after ischemic injury.	ros	168-171	dynamin 1 like	Homo sapiens	13-17
32377164-5	2020	The results showed that 2 mM NaB had a significant improvement effect on Abeta-induced N2a cell injury, by increasing cell viability and reducing ROS to reduce injury.	ros	146-149	amyloid beta (A4) precursor protein	Mus musculus	73-78
32129945-0	2020	Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.	ros	68-71	ubiquitin specific peptidase 10	Homo sapiens	7-12
32210950-5	2020	Further reduced iCa2+ flux induced ROS which lead to IFN-gamma reduction and increased IL-10 producing T suppressors through the STAT3-STAT5 axis.	ros	35-38	signal transducer and activator of transcription 5A	Homo sapiens	135-140
32190169-0	2020	The Reduced Oligomerization of MAVS Mediated by ROS Enhances the Cellular Radioresistance.	ros	48-51	mitochondrial antiviral signaling protein	Homo sapiens	31-35
32190169-3	2020	Our current study demonstrated that knockdown of MAVS alleviated the radiation-induced mitochondrial dysfunction (mitochondrial membrane potential disruption and ATP production), downregulated the expressions of proapoptotic proteins, and reduced the generation of ROS in cells after irradiation.	ros	265-268	mitochondrial antiviral signaling protein	Homo sapiens	49-53
32190169-4	2020	Furthermore, inhibition of mitochondrial ROS by the mitochondria-targeted antioxidant MitoQ reduced amounts of oligomerized MAVS after irradiation compared with the control group and also prevented the incidence of MN and increased the survival fraction of normal A549 cells after irradiation.	ros	41-44	mitochondrial antiviral signaling protein	Homo sapiens	124-128
32190169-5	2020	To our knowledge, it is the first report to indicate that MAVS, an innate immune signaling molecule, is involved in radiation response via its oligomerization mediated by radiation-induced ROS, which may be a potential target for the precise radiotherapy or radioprotection.	ros	189-192	mitochondrial antiviral signaling protein	Homo sapiens	58-62
31629709-7	2020	The JNK inhibitor and ROS scavenger NAC rescued the cell apoptosis and cycle inhibition elicited by schisantherin A.	ros	22-25	synuclein alpha	Homo sapiens	36-39
31884344-4	2020	Additionally, HBx induces oxidative stress by upregulating the production of ROS.	ros	77-80	X protein	Hepatitis B virus	14-17
31465746-6	2020	Moreover, SOD3 suppressed LL-37-induced expression of inflammatory mediators, ROS production and p38/ERK activation in mast cells.	ros	78-81	superoxide dismutase 3, extracellular	Mus musculus	10-14
31444399-10	2020	The endotoxin was shown to upregulate the expression of TRPM7 via the TLR4/NOX-2/ROS/NF-kappaB pathway and induce a TRPM7-dependent EC Ca2+ overload.	ros	81-84	toll like receptor 4	Homo sapiens	70-74
31770088-5	2020	Analyzing these data, we find that soon after injury the immediate early transcription factor MYC induces a battery of genes that respond to the MTZ-induced ROS by activating oxido-reductase pathways and apoptosis machinery.	ros	157-160	MYC proto-oncogene, bHLH transcription factor a	Danio rerio	94-97
31919413-13	2020	In summary, GSK3beta by blunting the anti-oxidant response and particularly NQO1 and NQO2 expression, favors the appearance of necrosis in response to ROS, as generated by the quinone DMNQ.	ros	151-154	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	85-89
32718291-7	2020	In addition, the transfected p-SIRT1 significantly suppressed the release of LDH and SOD compared with cells co-transfected with SIRT1 and FOXO3a group and cells induced by I/R and transfected with p-SNHG12group and overexpression of cells co-transfected with SIRT1 and FOXO3 further decreased the I/R-induced release of ROS and MDA.	ros	321-324	sirtuin 1	Mus musculus	31-36
31738662-5	2020	In this study, we address whether the new PrC-210 ROS-scavenger is effective in protecting p53-deficient (p53-/-) mice against X-ray-induced accelerated tumor mortality; this is the most sensitive radiation tumorigenesis model currently known.	ros	50-53	transformation related protein 53, pseudogene	Mus musculus	91-94
31738662-5	2020	In this study, we address whether the new PrC-210 ROS-scavenger is effective in protecting p53-deficient (p53-/-) mice against X-ray-induced accelerated tumor mortality; this is the most sensitive radiation tumorigenesis model currently known.	ros	50-53	transformation related protein 53, pseudogene	Mus musculus	106-109
31738662-10	2020	Essentially, the moles of PrC-210 thiol within a single 0.5 MTD PrC-210 dose suppressed the moles of ROS generated by 40% of the 4 Gy X-ray dose administered to p53-/- pups, and in doing so, eliminated the lifetime leukemia/lymphoma risk normally residing "downstream" of that 40% of the 4 Gy dose.	ros	101-104	transformation related protein 53, pseudogene	Mus musculus	161-164
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	ros	34-37	synuclein alpha	Homo sapiens	49-52
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	ros	34-37	interleukin 1 alpha	Homo sapiens	119-127
31553646-0	2019	Force generated by myosin cross-bridges is reduced in myofibrils exposed to ROS/RNS.	ros	76-79	myosin heavy chain 14	Homo sapiens	19-25
31553646-2	2019	There is indirect evidence that reactive oxygen/nitrogen species (ROS/RNS) affect skeletal muscle myofibrillar function, although the details of the acute effects of ROS/RNS on myosin-actin interactions are not known.	ros	166-169	myosin heavy chain 14	Homo sapiens	177-183
31325826-9	2019	On the other hand, the dose of 50 mgF/L, when administered for 20 days, reduced the enzymes involved in all energetic pathways, indicating a lower rate of energy production, with less generation of ROS and consequent reduction of antioxidant enzymes.	ros	198-201	KIT ligand	Rattus norvegicus	34-37
31440985-6	2019	PSGM-HCNPs re-polarized IL-4 polarized RAW 264.7 cells via a phenotypic switch from M2- to M1-like by elevating ROS level, decreasing CD206 and arginase-1 expressions and increasing pro-inflammatory cytokines" secretion.	ros	112-115	interleukin 4	Mus musculus	24-28
31514018-1	2019	(NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism.	ros	152-155	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	0-30
31514018-1	2019	(NRH):quinone oxidoreductase 2 (NQO2) is associated with various processes involved in cancer initiation and progression probably via the production of ROS during quinone metabolism.	ros	152-155	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	32-36
31723205-2	2019	We recently reported that ras guanyl nucleotide releasing protein 2 (RasGRP2), which is a guanine nucleotide exchange factor, was expressed in the human umbilical vein endothelial cells (HUVECs) and that Rap1 activation by its overexpression inhibited apoptosis by suppressing tumor necrosis factor-alpha induced-reactive oxygen species (ROS) production.	ros	338-341	RAP1A, member of RAS oncogene family	Homo sapiens	204-208
31377650-9	2019	These findings were likely due to inhibition of COL1A1 resulting in high levels of ROS in the cells, a decrease in mitochondrial membrane potential, an increase in intracellular autophagy, activation of the apoptotic pathway, and a decrease in lactic acid conversion ability.	ros	83-86	collagen type I alpha 1 chain	Bos taurus	48-54
31390228-12	2019	In conclusion, Ang II promotes MerTK shedding via AT1R/ROS/p38MAPK/ADAM17 pathway in macrophages, which led to defective efferocytosis and atherosclerosis progression.	ros	55-58	MER proto-oncogene, tyrosine kinase	Homo sapiens	31-36
31374478-7	2019	Furthermore, the increased expression level of these ligands highly relied on ROS overproduction-triggered DNA damage and the downstream ATM and ATR pathways.	ros	78-81	ATM serine/threonine kinase	Homo sapiens	137-140
30670828-3	2019	ATM-deficient cells show increased ROS accumulation, activation of p38 protein kinase, and increased levels of DNA damage.	ros	35-38	ATM serine/threonine kinase	Homo sapiens	0-3
31173878-0	2019	Effects of PP2A/Nrf2 on experimental diabetes mellitus-related cardiomyopathy by regulation of autophagy and apoptosis through ROS dependent pathway.	ros	127-130	protein phosphatase 2 phosphatase activator	Homo sapiens	11-15
31590928-7	2019	We then demonstrated that knockdown of GPX4, CAT, or GSR induced chemoresistance through elevation of ROS level and activation of Nrf2-ABCG2 pathway in BTC cell lines.	ros	102-105	glutathione peroxidase 4	Homo sapiens	39-43
31829064-4	2019	Molecular investigations showed that LATS2 overexpression was associated with mitochondrial injury, as evidenced by increased mitochondrial ROS production, reduced antioxidant factor levels, increased cyt-c liberation into the nucleus and activated mitochondrial caspase-9-dependent apoptotic pathway activity.	ros	140-143	large tumor suppressor kinase 2	Rattus norvegicus	37-42
30686777-6	2019	Finally, we dwell upon one of the key regulators of PP2A in cancer cells-cellular redox status-its multifarious nature, and its integration into the reactome of PP2A, highlighting some of the significant impacts that ROS can inflict on the structural modifications and functional aspect of PP2A.	ros	217-220	protein phosphatase 2 phosphatase activator	Homo sapiens	52-56
30686777-6	2019	Finally, we dwell upon one of the key regulators of PP2A in cancer cells-cellular redox status-its multifarious nature, and its integration into the reactome of PP2A, highlighting some of the significant impacts that ROS can inflict on the structural modifications and functional aspect of PP2A.	ros	217-220	protein phosphatase 2 phosphatase activator	Homo sapiens	161-165
30686777-6	2019	Finally, we dwell upon one of the key regulators of PP2A in cancer cells-cellular redox status-its multifarious nature, and its integration into the reactome of PP2A, highlighting some of the significant impacts that ROS can inflict on the structural modifications and functional aspect of PP2A.	ros	217-220	protein phosphatase 2 phosphatase activator	Homo sapiens	161-165
31364822-8	2019	NAC, an ROS scavenger, almost completely reversed both the cytotoxic and p38 MAPK pathway-activating effects of siphonodictyal B.	ros	8-11	synuclein alpha	Homo sapiens	0-3
31202710-5	2019	In parallel, the production of ROS and increased inflammation-associated genes in response to GP were also reduced upon MKP-5 overexpression.	ros	31-34	dual specificity phosphatase 10	Mus musculus	120-125
30719617-4	2019	Several newly identified mitochondrial proteins in mitochondrial outer membrane such as mitochondrial antiviral signaling protein (MAVS) and with mitochondrial DNA acting as danger-associated molecular pattern (DAMP) and mitochondrial ROS generated from mitochondrial sources have potentially established mitochondria as key signaling platforms in antiviral immunity in vertebrates and thereby orchestrating adaptive immune cell activations respectively.	ros	235-238	mitochondrial antiviral signaling protein	Homo sapiens	88-129
30719617-4	2019	Several newly identified mitochondrial proteins in mitochondrial outer membrane such as mitochondrial antiviral signaling protein (MAVS) and with mitochondrial DNA acting as danger-associated molecular pattern (DAMP) and mitochondrial ROS generated from mitochondrial sources have potentially established mitochondria as key signaling platforms in antiviral immunity in vertebrates and thereby orchestrating adaptive immune cell activations respectively.	ros	235-238	mitochondrial antiviral signaling protein	Homo sapiens	131-135
30343367-8	2019	Co-treatment of astrocytes with low concentrations of ODN dose-dependently blocked 6-OHDA-evoked production of ROS and inhibition of antioxidant enzyme activities.	ros	111-114	diazepam binding inhibitor	Rattus norvegicus	54-57
31134485-10	2019	In the in vitro studies, TBN inhibited H2O2-induced bEnd.3 cell apoptosis and reduced ROS generation.	ros	86-89	TATA-box binding protein associated factor 8	Mus musculus	25-28
28698136-7	2019	We also found that GPA1 constitutively interacts with the NADPH oxidase RbohD to potentiate flg22-induced ROS burst independently of the central cytoplasmic kinase BIK1.	ros	106-109	G protein alpha subunit 1	Arabidopsis thaliana	19-23
31130519-4	2019	We determined that PAA covalently binds to the conserved cysteine site of peroxiredoxins I/II (Prxs-I/II) and inhibits their catalytic activity, subsequently activating the ROS/ERK axis and the immunogenicity of HCC toward NK cells.	ros	173-176	peroxiredoxin 1	Homo sapiens	95-104
31194992-14	2019	Furthermore, ASP treatment inhibited H2O2-induced ROS generation and apoptosis via the activated ERK1/2-SOD2 pathway.	ros	50-53	fibrillin 1	Homo sapiens	13-16
31412804-0	2019	Uric acid regulates NLRP3/IL-1beta signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux.	ros	128-131	interleukin 1 alpha	Homo sapiens	26-34
31412804-13	2019	CONCLUSIONS: UA could regulate NLRP3/IL-1beta signaling pathway through ROS activation and K+ efflux and further induce vascular endothelial cells injury in early stages of CKD.	ros	72-75	interleukin 1 alpha	Homo sapiens	37-45
31391058-10	2019	Moreover, Jinfukang induces apoptosis in CTC-TJH-01 cells through the ROS-mediated ATM/ATR-p53 pathway and DNA damage.	ros	70-73	ATM serine/threonine kinase	Homo sapiens	83-86
32110512-8	2020	Moreover, Hic-5 plays a central role in a positive feedback Hic-5-NADPH oxidase-ROS-JNK signal cascade.	ros	80-83	transforming growth factor beta 1 induced transcript 1	Homo sapiens	10-15
32110512-8	2020	Moreover, Hic-5 plays a central role in a positive feedback Hic-5-NADPH oxidase-ROS-JNK signal cascade.	ros	80-83	transforming growth factor beta 1 induced transcript 1	Homo sapiens	60-65
31153046-0	2019	Carbon monoxide releasing molecule-2 protects against particulate matter-induced lung inflammation by inhibiting TLR2 and 4/ROS/NLRP3 inflammasome activation.	ros	124-127	NLR family, pyrin domain containing 3	Mus musculus	128-133
31534504-0	2019	CPX Targeting DJ-1 Triggers ROS-induced Cell Death and Protective Autophagy in Colorectal Cancer.	ros	28-31	Parkinsonism associated deglycase	Homo sapiens	14-18
31332209-2	2019	We found that as ROS and inflammation levels increased during aging, steroidogenic enzymes (StAR and P450scc) reduced and led to the decline of testosterone production eventually.	ros	17-20	steroidogenic acute regulatory protein	Mus musculus	92-96
31379894-8	2019	Through chemical and genetic approaches, we find that PTI-related transcriptional responses induced by Put are hydrogen peroxide and NADPH oxidase (RBOHD and RBOHF) dependent, thus suggesting that apoplastic ROS mediates Put signaling.	ros	208-211	respiratory burst oxidase protein F	Arabidopsis thaliana	158-163
31300673-7	2019	A single nucleotide polymorphism in the ROS-generating NOX3 gene is associated with beneficial DMF treatment-response.	ros	40-43	NADPH oxidase 3	Homo sapiens	55-59
31384532-7	2019	We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway.	ros	173-176	NLR family, pyrin domain containing 3	Mus musculus	36-41
31384532-7	2019	We found that aspirin could inhibit NLRP3 inflammasome formation and activation in vitro in dose-dependent manner and has correlation between the NLRP3 inflammasome and the ROS/TXNIP pathway.	ros	173-176	NLR family, pyrin domain containing 3	Mus musculus	146-151
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	glutathione S-transferase pi 1	Homo sapiens	244-271
26023743-5	2015	To its underlying mechanistic on ROS system, 4-HNE elevated the ROS generation enzyme NADPH oxidase 4 (NOX4) and induced the activation of NF-E2-related factor-2 (NRF2) and its downstream effectors: NAD(P)H dehydrogenase (quinone 1) (NQO1) and glutathione S-transferase P (GSTP).	ros	33-36	glutathione S-transferase pi 1	Homo sapiens	273-277
25961287-10	2015	Finally, pretreatment with ROS inhibitors, prevented gAcrp-induced SIRT1 expression and further generated inhibitory effects on gAcrp-induced autophagy, indicating a role of ROS production in gAcrp-induced SIRT1 expression and subsequent autophagy induction.	ros	27-30	sirtuin 1	Mus musculus	67-72
25961287-10	2015	Finally, pretreatment with ROS inhibitors, prevented gAcrp-induced SIRT1 expression and further generated inhibitory effects on gAcrp-induced autophagy, indicating a role of ROS production in gAcrp-induced SIRT1 expression and subsequent autophagy induction.	ros	27-30	sirtuin 1	Mus musculus	206-211
25961287-10	2015	Finally, pretreatment with ROS inhibitors, prevented gAcrp-induced SIRT1 expression and further generated inhibitory effects on gAcrp-induced autophagy, indicating a role of ROS production in gAcrp-induced SIRT1 expression and subsequent autophagy induction.	ros	174-177	sirtuin 1	Mus musculus	206-211
25795137-7	2015	Excess intracellular ROS induced by Dex significantly suppressed the expression levels of Nrf2 and the downstream effectors, HO1 and NQO1, but these changes could be reversed by I3C.	ros	21-24	heme oxygenase 1	Homo sapiens	125-128
28706677-3	2015	In particular, the ARS-NBA system with a high binding affinity can preferably react with peroxynitrite over hydrogen peroxide and other ROS/RNS due to the protection of the boron via the solvent-insertion B-N interaction.	ros	136-139	secreted LY6/PLAUR domain containing 1	Homo sapiens	19-22
25767116-4	2015	Recombinant ROS-GCs synthesized cGMP from GTP at faster rates in the presence of bicarbonate with an ED50 of 27 mM for ROS-GC1 and 39 mM for ROS-GC2.	ros	12-15	guanylate cyclase 2D, retinal	Homo sapiens	119-126
30954547-0	2019	The apoptosis and GLP-1 hyposecretion induced by LPS via RIP/ROS/mTOR pathway in GLUTag cells.	ros	61-64	regulation of phenobarbitol-inducible P450	Mus musculus	57-60
30954547-7	2019	Further studies showed that ROS inhibited the mTOR signaling pathway.	ros	28-31	mechanistic target of rapamycin kinase	Mus musculus	46-50
30954547-10	2019	Taken together, our result revealed that LPS induced the apoptosis of GLUTag cells and GLP-1 hyposecretion through the RIP/ROS/mTOR pathway.	ros	123-126	regulation of phenobarbitol-inducible P450	Mus musculus	119-122
25909160-5	2015	Also, IL-32alpha increased ROS production to induce prolonged JNK activation.	ros	27-30	interleukin 32	Homo sapiens	6-16
2471503-0	1988	A study of ROS induced denaturation of IgG3 using monoclonal antibodies; implications for inflammatory joint disease.	ros	11-14	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	39-43
25835394-5	2015	CE induced the expression of HO-1 as well as C-reactive protein (CRP) and NADPH oxidase 4 (NOX4), which are associated with ROS production.	ros	124-127	heme oxygenase 1	Homo sapiens	29-33
25835394-9	2015	Treatment with carbon monoxide releasing molecule-2 (CORM-2) significantly inhibited CE-induced ROS production, while the addition of HO-1 inhibitor, significantly increased CE-induced ROS production and apoptosis, suggesting a protective role of HO-1 or its reaction product, CO, in CE-induced apoptosis.	ros	185-188	heme oxygenase 1	Homo sapiens	134-138
25774506-8	2015	Moreover, BMP activation increased intracellular ROS levels, initiating an NRF2-mediated oxidative response during basal progenitor cell differentiation.	ros	49-52	bone morphogenetic protein 1	Homo sapiens	10-13
25798621-2	2015	Here, we demonstrate that the NOTCH1 pathway dictates activation of M1 phenotypes in isolated mouse hepatic macrophages (HMacs) and in a murine macrophage cell line by coupling transcriptional upregulation of M1 genes with metabolic upregulation of mitochondrial oxidative phosphorylation and ROS (mtROS) to augment induction of M1 genes.	ros	293-296	notch 1	Mus musculus	30-36
31026729-13	2019	Taken together, we showed that HSA attenuates GCI/R-induced brain damage and may be neuroprotective via regulation of the Wnt/beta-catenin/ROS signaling pathway.	ros	139-142	catenin beta 1	Rattus norvegicus	126-138
2835728-4	1987	Furthermore, protease digestion of intact UR2-transformed cells removed the putative extracellular domain (the p19 portion in P68gag-ros), leaving peptide fragments (p48/p46) which conformed to the size of the ros-encoded sequence in P68.	ros	133-136	interleukin 23 subunit alpha	Homo sapiens	111-114
25785991-8	2015	In lung epithelial cells, TGF-beta1 induced mitochondrial depolarization, mitochondrial ROS, and PINK1 expression; all were abrogated by mitochondrial ROS scavenging.	ros	151-154	PTEN induced putative kinase 1	Mus musculus	97-102
25519845-2	2015	Modulations in ROS/RNS levels in the mitochondria are often reflected through oxidation/nitrosation of highly redox-sensitive cysteine residues within this organelle.	ros	15-18	FAM20C golgi associated secretory pathway kinase	Homo sapiens	19-22
2835728-4	1987	Furthermore, protease digestion of intact UR2-transformed cells removed the putative extracellular domain (the p19 portion in P68gag-ros), leaving peptide fragments (p48/p46) which conformed to the size of the ros-encoded sequence in P68.	ros	210-213	interleukin 23 subunit alpha	Homo sapiens	111-114
3529088-3	1986	Thus, the c-ros gene joins the c-myb oncogene, which is distal to the c-ros gene on the long arm of human chromosome 6, as a candidate for involvement in chromosome 6q deletions and rearrangements seen in various malignancies.	ros	12-15	MYB proto-oncogene, transcription factor	Homo sapiens	31-36
25451639-7	2015	Incubation of Gch1(fl/fl)Tie2cre macrophages with dihydroethidium revealed significantly increased production of superoxide in the presence of iNOS expression, and an iNOS-independent, BH4-dependent increase in other ROS species.	ros	217-220	GTP cyclohydrolase 1	Mus musculus	14-18
2983097-2	1985	The UR2-specific transforming sequence, ros, with a length of 1,273 nucleotides, is inserted between the truncated gag gene coding for p19 and the env gene coding for gp37 of the UR2AV helper virus.	ros	40-43	interleukin 23 subunit alpha	Homo sapiens	135-138
25375771-0	2015	Synthesis of a novel cyclic prodrug of S-allyl-glutathione able to attenuate LPS-induced ROS production through the inhibition of MAPK pathways in U937 cells.	ros	89-92	interferon regulatory factor 6	Homo sapiens	77-80
25375771-6	2015	Biological studies revealed that CP11 is able to modulate inflammation mediated by LPS in U937 cells preventing the increase of ROS intracellular levels through interaction with the MAPK pathway.	ros	128-131	interferon regulatory factor 6	Homo sapiens	83-86
719068-1	1978	The rate of rhodopsin regeneration in decolorized rod outer segments ROS of pollock and ruff in the presence of exogenous 11Z-retinal is found to depend slightly on the temperature.	ros	69-72	rhodopsin	Bos taurus	12-21
25824798-6	2015	The RIPK1 kinase inhibitor necrostatin-1 and the ROS scavenger NAC each could prevent necrosis in HT-29 cells and the efficiency was enhanced by combined treatment.	ros	49-52	synuclein alpha	Homo sapiens	63-66
25451482-7	2015	We further demonstrated that STAT6 silencing elicited ER stress-mediated apoptosis in NCI-H460 cells through C/EBP homologous protein (CHOP) induction, alteration of BH3 only proteins expression and ROS production.	ros	199-202	signal transducer and activator of transcription 6	Homo sapiens	29-34
25451482-8	2015	The apoptosis induced by STAT6 downregulation was partially reversed by NAC, the ROS scavenger.	ros	81-84	signal transducer and activator of transcription 6	Homo sapiens	25-30
25451482-8	2015	The apoptosis induced by STAT6 downregulation was partially reversed by NAC, the ROS scavenger.	ros	81-84	synuclein alpha	Homo sapiens	72-75
25591955-5	2015	Moreover, treatment of macrophages with 15d-PGJ2, a natural PPAR-gamma ligand, significantly reduced Ang II-induced expression of Egr-1 and its inflammatory gene targets (IL-1beta, TNF-alpha, TGF-beta, MCP-1 and ICAM-1) through PPAR-gamma activation and ROS formation.	ros	254-257	early growth response 1	Homo sapiens	130-135
719068-7	1978	Trimethylcyclohexene derivatives with a side chain of about 7 carbon atoms and 13Z-retinal competitively inhibited the rhodopsin regeneration in pollock and bovine ROS, while 13E-11, 12-dehydroretinal and all-E-retinal did not effect this process.	ros	164-167	rhodopsin	Bos taurus	119-128
25681-9	1978	After proteolysis of ROS with papain, a fragment with molecular weight 24500 +/- 1000 was detected, which contained the same number of SH-groups and cysteine residues as in the case of intact rhodopsin.	ros	21-24	rhodopsin	Bos taurus	192-201
25834699-4	2015	Moreover, TNFR1 can directly induce oxidative stress by the activation of ROS and RNS producing enzymes.	ros	74-77	TNF receptor superfamily member 1A	Homo sapiens	10-15
33711553-0	2021	919 syrup inhibits ROS-mediated leptin-induced anorexia by activating PPARgamma and improves gut flora abnormalities.	ros	19-22	leptin	Mus musculus	32-38
33836263-6	2021	MiR-145-5p mimic in cells deteriorated ROS levels and decreased Sirt5 expression to accentuate oxidative stress by regulating the expression levels of SOD1, Nrf2, Keap1, which were all reversed by dioscin.	ros	39-42	microRNA 145	Rattus norvegicus	0-7
25361011-2	2014	We previously showed that ROS increased HBx levels and here, we investigated the role of antioxidants in the regulation of HBx expression and their clinical relevance.	ros	26-29	X protein	Hepatitis B virus	40-43
25361011-2	2014	We previously showed that ROS increased HBx levels and here, we investigated the role of antioxidants in the regulation of HBx expression and their clinical relevance.	ros	26-29	X protein	Hepatitis B virus	123-126
25361011-6	2014	The Cys at position 69 of HBx was crucial to maintain its protein stability and transactivation function in response to ROS.	ros	120-123	X protein	Hepatitis B virus	26-29
25520741-14	2014	CONCLUSIONS: Collectively, our results demonstrated that Bach1 plays an important role in Hcy-triggered ROS generations through inhibiting HO-1 expression, likely, resulting from the disturbed interplay between Bach1 and Nrf2.	ros	104-107	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	57-62
25520741-14	2014	CONCLUSIONS: Collectively, our results demonstrated that Bach1 plays an important role in Hcy-triggered ROS generations through inhibiting HO-1 expression, likely, resulting from the disturbed interplay between Bach1 and Nrf2.	ros	104-107	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	211-216
34055976-0	2021	PCB118 Induces Inflammation of Islet Beta Cells via Activating ROS-NLRP3 Inflammasome Signaling.	ros	63-66	NLR family, pyrin domain containing 3	Mus musculus	67-72
34055976-4	2021	In this study, we explored whether ROS-induced NLRP3 inflammasome priming and activation were related to PCB118 exposure in mouse islet beta-TC-6 cells and the mechanisms of diabetes.	ros	35-38	NLR family, pyrin domain containing 3	Mus musculus	47-52
34015313-9	2021	In cardiomyocytes, pretreatment with exogenous leptin prior to LPS reduced the expression of both pro-inflammatory genes, enhanced the expression of the antioxidant genes HO-1, SOD2 and HIF-1alpha, and lowered ROS staining.	ros	210-213	leptin	Mus musculus	47-53
34015313-11	2021	Together, these findings have indicated that under LPS, leptin concomitantly downregulated pro-inflammatory genes, upregulated antioxidant genes, and lowered ROS levels.	ros	158-161	leptin	Mus musculus	56-62
33288900-6	2021	This regulation is mechanistically attributed to DNA hydroxymethylation fostered WDR76 interaction with LSH and increased ratio of DCAF8 to WDR76 for antagonistic LSH association accompanying decreased DNA oxidation along with ROS overproduction.	ros	227-230	WD repeat domain 76	Homo sapiens	140-145
33548240-9	2021	Overexpression of AMPD3 in H9c2 cells elevated levels of hypoxanthine and ROS and reduced the level of ATP.	ros	74-77	adenosine monophosphate deaminase 3	Rattus norvegicus	18-23
33030694-6	2021	In comparison, Cys-SLN (5 muM) is more effective than Cys-CS-NC (10 muM) groups to improve the expression of antioxidant genes (SOD, CAT, GPx) or anti-apoptotic (BCL-2) gene and decreased apoptosis (BAX and caspase-3) or intra-/extracellular ROS levels.	ros	242-245	sarcolipin	Mus musculus	19-22
31004593-6	2019	Furthermore, knockdown of lnc-p21 mitigated MPP+-induced oxidative stress and neuroinflammation, as evidenced by the decrease in ROS generation, increase in SOD activity and decline in TNF-alpha, IL-1beta and IL-6 levels.	ros	129-132	H3 histone pseudogene 16	Homo sapiens	30-33
33837217-3	2021	MOCCI, a paralog of the NDUFA4 subunit of cytochrome C oxidase (Complex IV), replaces NDUFA4 in Complex IV during inflammation to lower mitochondrial membrane potential and reduce ROS production, leading to cyto-protection and dampened immune response.	ros	180-183	NDUFA4 mitochondrial complex associated	Homo sapiens	86-92
31130450-7	2019	Current patients were more likely to receive second-line anti-PD-L1 therapy if they had poorer Eastern Cooperative Oncology Group (ECOG) performance status (&gt;=2), had squamous histology, or had no epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), or ROS proto-oncogene 1 mutations.	ros	278-281	CD274 molecule	Homo sapiens	62-67
33576705-7	2021	Consistent with this, we found that Put signaling is mainly ROS dependent and partly compromised by ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), SALICYLIC ACID INDUCTION DEFICIENT 2 (SID2) and NONEXPRESSOR of PR GENES1 (NPR1) loss-of-function mutations.	ros	60-63	ADC synthase superfamily protein	Arabidopsis thaliana	179-183
31170524-6	2019	Knockout of PYROXD2 decreased MMP, intracellular ROS, complex IV activity, cell proliferation, ATP content and mtDNA copy number, but increased mtROS levels and the number of immature mitochondria.	ros	49-52	pyridine nucleotide-disulphide oxidoreductase domain 2	Homo sapiens	12-19
33383217-5	2021	Given that Slc7a11 could control ROS level through glutathione import, we measured intracellular ROS, then RANKL-induced ROS production was inhibited by alphaKG.	ros	33-36	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	107-112
31316342-8	2019	Interestingly, treatment of PARK20 cells with GSK2606414 (GSK), a specific inhibitor of PERK activity, restores the level of ROS, signaling a direct correlation between ER stress and the induction of oxidative stress in the PARK20 cells.	ros	125-128	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	88-92
33577944-0	2021	Cigarette smoke extract amplifies NADPH oxidase-dependent ROS production to inactivate PTEN by oxidation in BEAS-2B cells.	ros	58-61	phosphatase and tensin homolog	Homo sapiens	87-91
33577944-5	2021	Additionally, we found that ROS derived from DUOX1 and 2 of NADPH oxidase were mainly responsible for PTEN inactivation, and the excess of ROS also simultaneously led to Trx-1 inactivation by dimerization.	ros	28-31	phosphatase and tensin homolog	Homo sapiens	102-106
33577944-5	2021	Additionally, we found that ROS derived from DUOX1 and 2 of NADPH oxidase were mainly responsible for PTEN inactivation, and the excess of ROS also simultaneously led to Trx-1 inactivation by dimerization.	ros	28-31	thioredoxin	Homo sapiens	170-175
31235686-4	2019	Knockdown of endogenous miR-762 significantly attenuated the decrease in intracellular ATP levels, the increase in ROS levels, the decrease in mitochondrial complex I enzyme activity and the increase in apoptotic cell death in cardiomyocytes, which was induced by A/R treatment.	ros	115-118	microRNA 762	Mus musculus	24-31
33577944-5	2021	Additionally, we found that ROS derived from DUOX1 and 2 of NADPH oxidase were mainly responsible for PTEN inactivation, and the excess of ROS also simultaneously led to Trx-1 inactivation by dimerization.	ros	139-142	thioredoxin	Homo sapiens	170-175
31235686-8	2019	In addition, knockdown of endogenous ND2 significantly decreased intracellular ATP levels, increased ROS levels, reduced mitochondrial complex I enzyme activity and increased apoptotic cell death in cardiomyocytes, which was induced by A/R treatment.	ros	101-104	NADH dehydrogenase 2, mitochondrial	Mus musculus	37-40
33577944-8	2021	From the present study, we concluded that CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2, and the increased ROS led to the inactivation of PTEN, Trx-1 and Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	134-137	phosphatase and tensin homolog	Homo sapiens	165-169
33577944-8	2021	From the present study, we concluded that CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2, and the increased ROS led to the inactivation of PTEN, Trx-1 and Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	134-137	thioredoxin	Homo sapiens	171-176
33577944-8	2021	From the present study, we concluded that CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2, and the increased ROS led to the inactivation of PTEN, Trx-1 and Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	134-137	phosphatase and tensin homolog	Homo sapiens	254-258
33577944-13	2021	Additionally, we found that ROS derived from DUOX1 and 2 of NADPH oxidases were mainly responsible for oxidative inactivation PTEN, also simultaneously led to Trx-1 inactivation by dimerization.	ros	28-31	phosphatase and tensin homolog	Homo sapiens	126-130
33577944-13	2021	Additionally, we found that ROS derived from DUOX1 and 2 of NADPH oxidases were mainly responsible for oxidative inactivation PTEN, also simultaneously led to Trx-1 inactivation by dimerization.	ros	28-31	thioredoxin	Homo sapiens	159-164
33577944-16	2021	In conclusion, CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2 to oxidize PTEN and Trx-1 resulting in Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	60-63	phosphatase and tensin homolog	Homo sapiens	99-103
31209224-7	2019	Significantly increased cleavage of caspase-8 and subsequent high levels of apoptosis were found in livers of GsdmD-/- mice after HS/R, a relatively mild ROS-induced liver injury.	ros	154-157	caspase 8	Mus musculus	36-45
31209224-8	2019	However, during more severe APAP-mediated ROS-induced liver injury, caspase-8 cleavage in GsdmD-/- liver was inhibited compared with WT, resulting in accumulation of pro-caspase-8 and increased levels of necroptosis.	ros	42-45	caspase 8	Mus musculus	68-77
33577944-16	2021	In conclusion, CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2 to oxidize PTEN and Trx-1 resulting in Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	60-63	thioredoxin	Homo sapiens	108-113
33577944-16	2021	In conclusion, CSE exposure could elevate the intracellular ROS mainly from DUOX1 and 2 to oxidize PTEN and Trx-1 resulting in Akt activation, eventually cause the occurrence of COPD, suggesting that PTEN is a potential target for new therapies in COPD.	ros	60-63	phosphatase and tensin homolog	Homo sapiens	200-204
33040425-6	2021	Modulation of MMP-1 expression induced by UV radiation in human skin cells could be associated, at least in part, with the ROS scavenging capacity of "jarilla" extracts.	ros	123-126	matrix metallopeptidase 1	Homo sapiens	14-19
33758177-0	2021	Loss of QKI in macrophage aggravates inflammatory bowel disease through amplified ROS signaling and microbiota disproportion.	ros	82-85	quaking, KH domain containing RNA binding	Mus musculus	8-11
33421759-6	2021	Furthermore, combining with mitochondrial H2O2 probe-MitoPY1, the nanoprobe was also used to confirm the synergistic effect of Lon and ROS on hypoxia-induced apoptosis of cardiomyocytes and evaluate the function of ROS scavenger on attenuating such apoptosis.	ros	215-218	lon peptidase 1, mitochondrial	Homo sapiens	127-130
24532146-2	2014	The DJ-1 protein functions as a sensor of oxidative stress, acting both as a reactive oxygen species scavenger (ROS) and an antioxidative response regulator.	ros	112-115	Parkinsonism associated deglycase	Homo sapiens	4-8
33850858-7	2021	Intracellular ROS production was determined by measuring uptake of dichlorodihydrofluorescein diacetate (DCFH-DA; PCR was used to assay the mRNA expression of STAT3 gene bearing predicted targeting positions for miR-495, while qRT-PCR was used to measure miR-495 mRNA.	ros	14-17	signal transducer and activator of transcription 3	Rattus norvegicus	159-164
25320841-7	2014	Furthermore, DR5 expression induced by 1 was mediated via a ROS-independent pathway that required CHOP and p53.	ros	60-63	TNF receptor superfamily member 10b	Homo sapiens	13-16
25320841-8	2014	Overall, these findings provide evidence that 1 potentiates TRAIL-mediated apoptosis through up-regulation of DR5 via a ROS-independent pathway.	ros	120-123	TNF receptor superfamily member 10b	Homo sapiens	110-113
25341038-11	2014	The observed effect was ablated by the ROS scavenger--NAC.	ros	39-42	synuclein alpha	Homo sapiens	54-57
33264635-7	2021	POLG driven mitochondrial dysfunction also led to neuronal ROS overproduction and increased cellular senescence.	ros	59-62	DNA polymerase gamma, catalytic subunit	Homo sapiens	0-4
25290245-9	2014	More intriguing, SelP-H significantly attenuated Cu(2+)/Cu(+)-tau-R2-induced intracellular ROS production and the impairments of synapse and mitochondrial movement in neurons.	ros	91-94	selectin P	Homo sapiens	17-21
33502586-9	2021	CONCLUSION: VIP/FPRL1/VPAC/GTP-RhoA-GTPase signaling modulated macrophages phenotype through activation of multiple signaling pathways including ERK1/2, AKT, P38, ROS, cAMP and calcium.	ros	163-166	formyl peptide receptor 2	Homo sapiens	16-21
25321472-9	2014	In conclusion, our results suggest that Med sensitizes myeloid leukemia cells to TRAIL-induced apoptosis through the upregulation of DR5 through activation of the ROS-JNK-CHOP pathway.	ros	163-166	TNF receptor superfamily member 10b	Homo sapiens	133-136
24933647-5	2014	GADD153, in turn, down-regulated Bcl-2 protein to cause mitochondrial membrane potential loss and apoptosis through intracellular ROS generation.	ros	130-133	DNA-damage inducible transcript 3	Mus musculus	0-7
33527955-0	2021	The main anthocyanin monomer of Lycium ruthenicum Murray induces apoptosis through the ROS/PTEN/PI3K/Akt/caspase 3 signaling pathway in prostate cancer DU-145 cells.	ros	87-90	phosphatase and tensin homolog	Homo sapiens	91-95
25305377-7	2014	ROS further led to symptoms of early apoptosis by deregulating Akt (Protein Kinase B) and activating c-Jun N-terminal Kinase (JNK), p38 Mitogen Activated Protein Kinase (MAPK), p53, and autophagy starting from ~8h of incubation.	ros	0-3	protein tyrosine kinase 2 beta	Homo sapiens	68-84
33527955-10	2021	In addition, our results also suggested that Pt3G activated the PTEN gene to induce the apoptosis of DU-145 cells by stimulating the overproduction of ROS.	ros	151-154	phosphatase and tensin homolog	Homo sapiens	64-68
33596919-8	2021	Furthermore, the increase of mitochondrial ROS (mtROS) and CSC-marker expression induced by CIH exposure was abolished in Bach1 shRNA-treated lung cancer cells.	ros	43-46	BTB and CNC homology 1, basic leucine zipper transcription factor 1	Mus musculus	122-127
25038569-6	2014	ROS production subsequently activated p53 phosphorylation at Ser-15.	ros	0-3	transformation related protein 53, pseudogene	Mus musculus	38-41
24930757-9	2014	Finally, the generation of ROS was required for CHOP and DR5 up-regulation by ilimaquinone.	ros	27-30	TNF receptor superfamily member 10b	Homo sapiens	57-60
33546740-7	2021	Moreover, THP could protect RAW264.7 cells against H2O2-induced cytotoxicity by decreasing intracellular ROS levels, reducing catalase (CAT) and superoxide dismutase (SOD) activities, increasing lactate dehydrogenase (LDH) activity and increment in malondialdehyde (MDA) level.	ros	105-108	uromodulin	Mus musculus	10-13
24930757-10	2014	These results demonstrate that ilimaquinone enhanced the sensitivity of human colon cancer cells to TRAIL-induced apoptosis through ROS-ERK/p38 MAPK-CHOP-mediated up-regulation of DR4 and DR5 expression, suggesting that ilimaquinone could be developed into an adjuvant chemotherapeutic drug.	ros	132-135	TNF receptor superfamily member 10b	Homo sapiens	188-191
33541408-7	2021	Mechanically, KAT6A was found to regulate Nrf2/ARE signaling pathway and inhibit ROS accumulation in OBMSCs, thus promoting proliferation, colony formation, and osteogenic differentiation of OBMSCs.	ros	81-84	lysine acetyltransferase 6A	Homo sapiens	14-19
24802810-11	2014	Additionally, NAC attenuated the UA-induced elevation in cytosolic calcium, ER stress markers and autophagy-related proteins, indicating that UA triggered ER stress and autophagy via a ROS-dependent pathway.	ros	185-188	synuclein alpha	Homo sapiens	14-17
33541408-10	2021	KAT6A was downregulated in aging bone marrow-derived mesenchymal stem cells (BMSCs), and downregulation of KAT6A resulted in Nrf2/ARE signaling pathway inhibition and ROS accumulation, thus leading to decreased stemness of aging BMSCs.	ros	167-170	lysine acetyltransferase 6A	Homo sapiens	107-112
25047818-9	2014	CONCLUSIONS: These results indicate that the metabolic response to HTG in human apolipoprotein C-III overexpressing mice may support a high TG production rate and that the cytosol of hepatocytes is subjected to an important oxidative stress, probably as a result of FFA over-accumulation, iron overload and enhanced activity of some ROS-producing catabolic enzymes.	ros	333-336	apolipoprotein C3	Homo sapiens	80-100
32979141-5	2021	Quantitative real-time PCR and western blot analysis demonstrated that drug combination-induced mitochondrial apoptosis was activated through the ROS-mediated PERK/eIF2alpha/ATF4/CHOP pathway.	ros	146-149	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	159-163
24881581-1	2014	By incorporation of a specific NO-binding group, 2-amino-3"-dimethylaminobiphenyl, into a Bodipy dye, fluorescent probe was constructed, which exhibited high selectivity for NO over other ROS/RNS as well as DHA, AA and MGO.	ros	188-191	FAM20C golgi associated secretory pathway kinase	Homo sapiens	192-195
32156249-7	2021	Interestingly, treatment with each of the Abeta peptides resulted in a significant increase of intracellular ROS activity, as compared to untreated neurons.	ros	109-112	amyloid beta (A4) precursor protein	Mus musculus	42-47
24704296-4	2014	Cytotoxicity, CD30 down-modulation and CD30 shedding by DHMEQ were prevented by ROS scavenger NAC.	ros	80-83	synuclein alpha	Homo sapiens	94-97
33189448-7	2021	After blocking the corresponding pathway, it was found that ROS mediates ASK1 and JNK activation.	ros	60-63	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	73-77
33326693-7	2021	Combined treatment of IL-1beta+U73122-treated chondrocytes with inhibitors of apoptosis (Z-VAD, 10 muM) and necroptosis (Nec-1, 30 muM) enhanced the increases in levels and expression of Collagen2 and Aggrecan, and prevented the increases in cell death and ROS levels.	ros	257-260	proprotein convertase subtilisin/kexin type 1	Rattus norvegicus	121-126
33352154-6	2021	We also realized that SiO2 NPs increase the cytotoxicity of alpha-syn amyloid fibrils through a significant decrease in cell viability, increase in membrane leakage, activation of caspase-9 and -3, elevation of ROS, and increase in the ratio of Bax/Bcl2 mRNA.	ros	211-214	synuclein alpha	Homo sapiens	60-69
24602596-5	2014	The cAMP protein kinase Tpk3p is the catalytic subunit specifically involved in the regulation of mitochondrial biogenesis through regulation of the mitochondrial ROS production.	ros	163-166	cAMP-dependent protein kinase catalytic subunit TPK3	Saccharomyces cerevisiae S288C	24-29
30515791-6	2019	Our results reveal that Gpx3 suppression can significant increases in ROS (p &lt; 0.05) levels, which further induced apoptosis through upregulated the expression of Caspase-3 in cardiomyocytes.	ros	70-73	glutathione peroxidase 3	Gallus gallus	24-28
33250268-7	2021	The results showed that si-LincRNA-Cox2 was capable of increased the expression of apoptosis-associated proteins and accumulation of ROS in BCG-infected RAW264.7 cells.	ros	133-136	prostaglandin-endoperoxide synthase 2, opposite strand 2	Mus musculus	27-39
30573782-0	2019	B7-H3 promotes multiple myeloma cell survival and proliferation by ROS-dependent activation of Src/STAT3 and c-Cbl-mediated degradation of SOCS3.	ros	67-70	Rous sarcoma oncogene	Mus musculus	95-98
30573782-10	2019	These data indicate B7-H3"s important role in the activation of ROS/Src/c-Cbl pathway in multiple myeloma which integrates redox regulation and sustained STAT3 activation at the level of degradation of STAT3 suppressor.	ros	64-67	Rous sarcoma oncogene	Mus musculus	68-71
30573782-10	2019	These data indicate B7-H3"s important role in the activation of ROS/Src/c-Cbl pathway in multiple myeloma which integrates redox regulation and sustained STAT3 activation at the level of degradation of STAT3 suppressor.	ros	64-67	Casitas B-lineage lymphoma	Mus musculus	72-77
24792388-7	2014	To identify the physiological role of NTRA influencing ROS homeostasis by stress, NTRA overexpression (NTRAOX) and knock-out mutants (ntra-ko) were generated.	ros	55-58	NADPH-dependent thioredoxin reductase A	Arabidopsis thaliana	38-42
24792388-9	2014	ROS range was increased by MV in wild-type and ntra-ko plants, but not in NTRAOX.	ros	0-3	NADPH-dependent thioredoxin reductase A	Arabidopsis thaliana	47-51
24792388-12	2014	The results suggest that NTRA overexpression confers oxidative and drought tolerance by regulation of ROS amounts.	ros	102-105	NADPH-dependent thioredoxin reductase A	Arabidopsis thaliana	25-29
31004990-7	2019	Consistently, FoxO4-mediated ROS generation was attenuated upon inhibition of Brd4 with JQ1 or siRNA against Brd4.	ros	29-32	bromodomain containing 4	Mus musculus	78-82
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	ros	171-174	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	40-45
31004990-7	2019	Consistently, FoxO4-mediated ROS generation was attenuated upon inhibition of Brd4 with JQ1 or siRNA against Brd4.	ros	29-32	bromodomain containing 4	Mus musculus	109-113
31004990-9	2019	In conclusion, our results proved that Brd4 inhibition blocked renal apoptotic and ERS protein expression by preventing FoxO4-dependent ROS generation through the PI3K/AKT pathway, indicating that Brd4 could be a potential therapeutic target for renal I/R injury.	ros	136-139	bromodomain containing 4	Mus musculus	39-43
33499185-0	2021	5-O-Demethylnobiletin Alleviates CCl4-Induced Acute Liver Injury by Equilibrating ROS-Mediated Apoptosis and Autophagy Induction.	ros	82-85	C-C motif chemokine ligand 4	Homo sapiens	33-37
31004990-9	2019	In conclusion, our results proved that Brd4 inhibition blocked renal apoptotic and ERS protein expression by preventing FoxO4-dependent ROS generation through the PI3K/AKT pathway, indicating that Brd4 could be a potential therapeutic target for renal I/R injury.	ros	136-139	bromodomain containing 4	Mus musculus	197-201
31138329-0	2019	ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.	ros	0-3	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	59-65
31118506-7	2019	The Ang II receptor blocker losartan and the ROS scavenger NAC restored MYH9 expression in Ang II-treated podocytes, attenuated disrupted actin cytoskeleton and decreased albumin permeability.	ros	45-48	synuclein alpha	Homo sapiens	59-62
25272502-9	2014	CONCLUSION: CEE inhibited the H2O2-injured HepG2 cells by reducing the ROS level.	ros	71-74	guided entry of tail-anchored proteins factor 4	Homo sapiens	12-15
33207265-5	2021	At molecular level, PD-L1 up-regulation correlated with the activation of a positive regulatory circuit between the increase of intracellular ROS and the activation of STAT1 and STAT3 induced by HHV-6B, accompanied by a high release of pro-inflammatory/immune suppressive cytokines.	ros	142-145	CD274 molecule	Homo sapiens	20-25
24723500-5	2014	In silico analysis showed that hMSC stimulated antiapoptotic activity, normal ROS handling, energy production, cytoskeleton organization, protein synthesis, and cell proliferation.	ros	78-81	musculin	Homo sapiens	31-35
24723500-8	2014	Western blotting of proteins associated with ROS and energy metabolism confirmed their higher abundance in HK-2 cells exposed to hMSC.	ros	45-48	musculin	Homo sapiens	129-133
30415472-8	2019	Mechanistically, the survival advantage conferred by mtSSB was primarily caused by increased mitochondrial biogenesis and subsequent ROS production, which induced telomerase reverse transcriptase (TERT) expression and telomere elongation via Akt/mTOR pathway in CRC cells.	ros	133-136	telomerase reverse transcriptase	Homo sapiens	163-195
33446631-4	2021	The depletion of ARNT dramatically repressed PDK1 and NQO1 expression, which resulted in an increase of ROS levels.	ros	104-107	aryl hydrocarbon receptor nuclear translocator	Mus musculus	17-21
31123703-4	2019	Trim32 inhibition results in a defective autophagy response to muscle atrophy, associated with increased ROS and MuRF1 levels.	ros	105-108	tripartite motif-containing 32	Mus musculus	0-6
24590062-6	2014	In addition the ability of AKR7A5 to enable the cells to cope with ROS accumulation and glutathione depletion was assessed.	ros	67-70	aldo-keto reductase family 7, member A5 (aflatoxin aldehyde reductase)	Mus musculus	27-33
33220258-7	2021	Furthermore, mitochondrial stress-induced ROS production, as a feedback signal from mitochondria to the cell nucleus, increased PGC1alpha expression in SKOV3/DDP cells, which was involved in mitochondrial oxidative phosphorylation regulation.	ros	42-45	PPARG coactivator 1 alpha	Sus scrofa	128-137
24768635-8	2014	Moreover, when ATF3 knockdown cells were exposed to CsA, a prompt induction of CHOP was observed, which stimulated ROS production and induced cell death-related genes as compared to wild type.	ros	115-118	activating transcription factor 3	Homo sapiens	15-19
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	11-14	NLR family, pyrin domain containing 3	Mus musculus	44-49
24768635-9	2014	Taken together, our data demonstrate that ATF3 plays a pivotal role in the attenuation of CsA-induced nephrotoxicity by downregulating CHOP and ROS production mediated by ER stress.	ros	144-147	activating transcription factor 3	Homo sapiens	42-46
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	11-14	NLR family, pyrin domain containing 3	Mus musculus	128-133
24865768-10	2014	Moreover, ROS formation, the ratio of NADP+/NADPH and NADPH oxidase subunits expression of gp91phox and p47phox, lipid peroxidation level was significantly increased, while antioxidant enzyme SOD and GSH-Px activity were reduced in the myocardial tissue of diabetic mice.	ros	10-13	neutrophil cytosolic factor 1	Mus musculus	104-111
30716619-8	2019	Moreover, ROS detection using DCFDA, JC-1, and annexin V-FITC assays demonstrated the significant apoptosis induction by 10e.	ros	10-13	annexin A5	Homo sapiens	47-56
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	175-178	NLR family, pyrin domain containing 3	Mus musculus	44-49
33074353-16	2021	Scavenging ROS also significantly inhibited NLRP3 inflammasome activation without change of TSPO, indicating that TSPO-mediated NLRP3 inflammasome activation was dependent on ROS.	ros	175-178	NLR family, pyrin domain containing 3	Mus musculus	128-133
32557145-10	2021	Moreover, the depletion of NFKB1 enhanced the influences of naringin on cell proliferation and apoptosis as well as the expression of apoptosis-related proteins and ROS level.	ros	165-168	nuclear factor kappa B subunit 1	Rattus norvegicus	27-32
30615886-7	2019	TBI induced NLRP3 inflammasome activation and mitochondrial dysfunction, including increased caspase-1 p20 expression, exacerbated the secretion of LDH, IL-1beta and IL-18, and disorder of ATP, MMP, ROS and mitophagy (Pink1 and LC3 expression in mitochondria).	ros	199-202	NLR family, pyrin domain containing 3	Mus musculus	12-17
30738928-10	2019	Under pretreatment with NADPH oxidase inhibitors, intracellular ROS generation was confirmed to participate in oxLDL/beta2GPI/anti-beta2GPI complex-induced proliferation and apoptosis, as well as the phosphorylation of NF-kappaB and MAPKs.	ros	64-67	apolipoprotein H	Homo sapiens	117-125
30738928-10	2019	Under pretreatment with NADPH oxidase inhibitors, intracellular ROS generation was confirmed to participate in oxLDL/beta2GPI/anti-beta2GPI complex-induced proliferation and apoptosis, as well as the phosphorylation of NF-kappaB and MAPKs.	ros	64-67	apolipoprotein H	Homo sapiens	131-139
30738928-11	2019	Taken together, our data clearly revealed that the oxLDL/beta2GPI/anti-beta2GPI complex had biphasic effects on VSMC survival, partly mediated by ROS-induced NF-kappaB and MAPKs activation.	ros	146-149	apolipoprotein H	Homo sapiens	57-65
24810714-6	2014	Mitochondrial SB3 inhibits ROS generation and the ensuing PTP induction and cell death through an inhibitory interaction with respiratory Complex I.	ros	27-30	serpin family B member 3	Homo sapiens	14-17
24677687-2	2014	Reviewed are also specific interactions between mTOR/S6K1 and ROS-DNA damage signaling pathways.	ros	62-65	ribosomal protein S6 kinase B1	Homo sapiens	53-57
24677687-8	2014	While the primary target of each of these agents may be different the data obtained on several human cancer cell lines, WI-38 fibroblasts and normal lymphocytes suggest common downstream mechanism in which the decline in mTOR/S6K1 signaling and translation rate is coupled with a reduction of oxidative phosphorylation and ROS that leads to decreased oxidative DNA damage.	ros	323-326	ribosomal protein S6 kinase B1	Homo sapiens	226-230
26432589-9	2014	The mitochondrial inhibitors of rotenone and oligomycin eliminated heavy ion induced ROS generation in TK6 and HMy2.CIR cells and hence diminished the bystander effect on HL-7702 cells.	ros	85-88	corepressor interacting with RBPJ, CIR1	Homo sapiens	116-119
30738928-11	2019	Taken together, our data clearly revealed that the oxLDL/beta2GPI/anti-beta2GPI complex had biphasic effects on VSMC survival, partly mediated by ROS-induced NF-kappaB and MAPKs activation.	ros	146-149	apolipoprotein H	Homo sapiens	71-79
32902019-0	2021	Nodakenin alleviates renal ischemia-reperfusion injury via inhibiting ROS induced NLRP3 inflammasome activation.	ros	70-73	NLR family, pyrin domain containing 3	Mus musculus	82-87
30794944-5	2019	Intriguingly, PDH, KGDH, and SDH comprised up to ~95% of the ROS generating capacity of permeabilized 6N liver mitochondria, with PRODH, G3PDH, and BCKDH making minor contributions.	ros	61-64	aminoadipate-semialdehyde synthase	Mus musculus	29-32
30794944-8	2019	PRODH was also an important ROS source in 6J mitochondria, accounting for ~43% of the total H2O2 formed.	ros	28-31	proline dehydrogenase	Mus musculus	0-5
33130473-14	2021	Also, Hyp pretreatment reduced IL-1beta-induced overproduction of ROS and apoptosis of chondrocytes.	ros	66-69	interleukin 1 alpha	Mus musculus	31-39
24760518-8	2014	These findings suggest that an AT1R-dependent mechanism contributes to increased ROS observed in the ACE2KO.	ros	81-84	angiotensin II, type I receptor-associated protein	Mus musculus	31-35
33126053-3	2021	In vivo treatment with anti-TGFbeta completely attenuated NOX4 expression, restored DHFR protein abundance, reduced ROS production, recoupled eNOS and attenuated aneurysm formation.	ros	116-119	transforming growth factor alpha	Mus musculus	28-35
24350834-6	2014	The protective effect of melatonin and the reduction in OGD-induced ROS were prevented by luzindole (melatonin antagonist) and alpha-bungarotoxin (alpha-Bgt, a selective alpha7 nAChR antagonist).	ros	68-71	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	170-182
30647455-4	2019	MG132-mediated repression of AGR2 transcription was independent of ROS generation and ER stress induction, but partially resulted from the downregulated E2F1.	ros	67-70	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	29-33
31178965-0	2019	ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells.	ros	0-3	GATA binding protein 6	Homo sapiens	22-27
31178965-0	2019	ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells.	ros	0-3	interferon regulatory factor 6	Homo sapiens	71-74
31178965-6	2019	Furthermore, the levels of ROS were significantly increased in an LPS dose-dependent manner.	ros	27-30	interferon regulatory factor 6	Homo sapiens	66-69
31178965-8	2019	Elimination of LPS-stimulated ROS by melatonin or vitamin C could restore the expressions of GATA4, GATA6, and StAR.	ros	30-33	interferon regulatory factor 6	Homo sapiens	15-18
31178965-8	2019	Elimination of LPS-stimulated ROS by melatonin or vitamin C could restore the expressions of GATA4, GATA6, and StAR.	ros	30-33	GATA binding protein 6	Homo sapiens	100-105
24586453-4	2014	The sid2 mutant, impaired in SA biosynthesis, had less basal FLS2 mRNA accumulation than the wild type, which correlated with suppression of early flg22 responses such as ROS production and induction of marker genes, WRKY29 and FRK1.	ros	171-174	ADC synthase superfamily protein	Arabidopsis thaliana	4-8
33242555-13	2021	These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release.	ros	156-159	NLR family, pyrin domain containing 3	Mus musculus	169-174
33242555-13	2021	These results suggest that the working mechanisms by which AND down-regulates MSU-induced joint inflammation might be via HO-1 induction and attenuation of ROS-mediated NLRP3 inflammasome assembly and subsequent IL-1beta release.	ros	156-159	interleukin 1 alpha	Mus musculus	212-220
24252613-11	2014	A NOS inhibitor, L-NAME, and a ROS scavenger blocked the CM-mediated Hsp27 downregulation.	ros	31-34	heat shock protein family B (small) member 1	Homo sapiens	69-74
33364504-6	2020	ROS triggered JNK and ERK phosphorylation, and cyt c release outside mitochondria, not accompanied by caspases-9 and -3 activation, probably due to 3BP-dependent alkylation of cysteine residues at caspase-9 catalytic site.	ros	0-3	caspase 9	Homo sapiens	197-206
32598967-9	2020	In the presence of unchanged TNF induced signaling, ROS-mediated calcium release from the ER caused mitochondrial permeability transition and apoptosis, which identified a link between extrinsic death receptor signaling and cell-intrinsic mitochondrial-mediated caspase activation.	ros	52-55	caspase 8	Mus musculus	262-269
24161787-0	2014	Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy.	ros	99-102	heat shock protein 90 alpha family class A member 1	Homo sapiens	77-82
31192222-10	2019	In postmortem brains from the ROS/MAP dataset of normal and pathological aging, decreased NHE6 expression was correlated with greater tau deposition.	ros	30-33	solute carrier family 9 member A6	Homo sapiens	90-94
30826469-4	2019	Moreover, Nrf2 translocation appeared both in GD 12.5 d and GD 18.5 d. In conclusion, DON-induced ROS accumulation may cause maternal liver damage in the initial stages, but the related stimulation of Nrf2/HO-1 pathway improves the removal of ROS and decreases the level of oxidative stress thereby protecting the liver damage.	ros	243-246	heme oxygenase 1	Homo sapiens	206-210
24161787-7	2014	Moreover, the andrographolide-induced Hsp90 cleavage, Src degradation, inhibition of transformation, and induction of apoptosis were abolished by a ROS inhibitor, N-acetyl-cysteine.	ros	148-151	heat shock protein 90 alpha family class A member 1	Homo sapiens	38-43
32488847-3	2020	Here, we first demonstrated that the JNK/p66Shc signal pathway promoted ROS generation and inhibited the anti-oxidation effect of FoxO3a to induce oxidative stress damage after SCI and the mechanism of electro-acupuncture in anti-oxidative stress.	ros	72-75	mitogen-activated protein kinase 8	Rattus norvegicus	37-40
32488847-5	2020	Furthermore, p38MAPK-mediated microglia activation and inflammatory reaction and JNK/p66Shc-mediated ROS generation and oxidative stress damage were both attenuated by electro-acupuncture.	ros	101-104	mitogen-activated protein kinase 8	Rattus norvegicus	81-84
32488847-7	2020	Therefore, the activation of JNK/p66Shc promoted the ROS-induced oxidative stress damage after SCI, and inhibiting the phosphorylation of p66Shc-mediated oxidative stress was the key target of electro-acupuncture to facilitate functional recovery SCI, but not p38MAPK.	ros	53-56	mitogen-activated protein kinase 8	Rattus norvegicus	29-32
30862884-4	2019	We discovered that the pharmacological inhibition of 5HT1A led to the reduced proliferation of B cell-derived lymphoma cell lines together with DNA damage, ROS-independent caspase activation and apoptosis in a large fraction of cells.	ros	156-159	5-hydroxytryptamine receptor 1A	Homo sapiens	53-58
33007364-7	2020	Importantly, VPA-induced ROS accumulation and hepatic steatosis were attenuated when CYP2E1 was inhibited using CYP2E1 inhibitor, diallyl sulfide (DAS, 100 mg/kg in mice, 1 mM in LO2 cells) or in CYP2E1-knockdown cell line, suggesting that CYP2E1 plays a potential role in ROS production following hepatic steatosis.	ros	25-28	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	85-91
24096872-4	2014	In particular, nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL.	ros	152-155	proline dehydrogenase	Mus musculus	114-119
24096872-4	2014	In particular, nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL.	ros	152-155	patatin-like phospholipase domain containing 2	Mus musculus	179-183
30858416-0	2019	Physical plasma-triggered ROS induces tumor cell death upon cleavage of HSP90 chaperone.	ros	26-29	heat shock protein 90 alpha family class A member 1	Homo sapiens	72-77
24762600-7	2014	RESULTS: Over expression of SIRT3 increased glucose uptake and decreased ROS production in L6-IR cells as well as in L6 cells.	ros	73-76	sirtuin 3	Rattus norvegicus	28-33
33007364-7	2020	Importantly, VPA-induced ROS accumulation and hepatic steatosis were attenuated when CYP2E1 was inhibited using CYP2E1 inhibitor, diallyl sulfide (DAS, 100 mg/kg in mice, 1 mM in LO2 cells) or in CYP2E1-knockdown cell line, suggesting that CYP2E1 plays a potential role in ROS production following hepatic steatosis.	ros	273-276	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	85-91
24762600-8	2014	Knock-down of SIRT3 induced increased production of ROS while decreased glucose uptake in both L6 and L6-IR cells, and these effects were reversed by N-acetyl-L-cysteine (NAC).	ros	52-55	sirtuin 3	Rattus norvegicus	14-19
30858416-3	2019	Here we report that treatment of cancer cells with cold physical plasma, an emerging and less aggressive tumor therapy, resulted in ROS generation which subsequently triggered the cleavage of HSP90.	ros	132-135	heat shock protein 90 alpha family class A member 1	Homo sapiens	192-197
32270590-2	2020	In this study, we found that IGF-1 activated NF-kappaB and NLRP3 inflammatory signaling via IRS-1/mPGES-1/NOX2-regulated ROS.	ros	121-124	NLR family, pyrin domain containing 3	Mus musculus	59-64
30584985-7	2019	The parasite elimination was associated with generation of ROS and NO that are interrelated with up-regulation of disease-suppressing Th1 cytokines and down-regulation of disease-promoting Th2 cytokines at both protein and mRNA level.	ros	59-62	heart and neural crest derivatives expressed 2	Mus musculus	189-192
32270590-2	2020	In this study, we found that IGF-1 activated NF-kappaB and NLRP3 inflammatory signaling via IRS-1/mPGES-1/NOX2-regulated ROS.	ros	121-124	insulin receptor substrate 1	Mus musculus	92-97
24512708-6	2014	ROS appears as a common signal triggering cell death through MAPK and/or JNK pathway activation.	ros	0-3	mitogen-activated protein kinase 8b	Danio rerio	73-76
32270590-2	2020	In this study, we found that IGF-1 activated NF-kappaB and NLRP3 inflammatory signaling via IRS-1/mPGES-1/NOX2-regulated ROS.	ros	121-124	prostaglandin E synthase	Mus musculus	98-105
33239070-7	2020	The ROS-induced metabolic dysregulation and phosphorylation of necrosome complex by YARS were assessed using oxygen consumption rate analysis, flow cytometry analysis, and 3D cell viability assay.	ros	4-7	tyrosyl-tRNA synthetase 1	Homo sapiens	84-88
24955209-5	2014	Defects in the insulin/insulin-like growth factor-1 signaling pathway or increased ROS levels induce the conserved phase II detoxification response via the SKN-1 pathway to fight against oxidative stress.	ros	83-86	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	156-161
24494188-4	2014	By overexpression and knockdown experiments, we showed that Nox1 on a post-translational level regulated the stability of CK18 in an ROS-, phosphorylation- and PKCepilon-dependent manner.	ros	133-136	keratin 18	Homo sapiens	122-126
30664710-0	2019	OxHDL controls LOX-1 expression and plasma membrane localization through a mechanism dependent on NOX/ROS/NF-kappaB pathway on endothelial cells.	ros	102-105	oxidized low density lipoprotein receptor 1	Rattus norvegicus	15-20
33239070-12	2020	YARS-induced necroptosis sequentially mediated mitochondrial dysfunction through the overproduction of ROS in breast cancer cell lines.	ros	103-106	tyrosyl-tRNA synthetase 1	Homo sapiens	0-4
24268699-6	2013	Moreover, we found that ROS-induced autophagy acts as a negative feedback regulator of JNK activity by dissociating Atg9/mAtg9 from dTRAF2/TRAF6 in Drosophila and mammalian cells, respectively.	ros	24-27	basket	Drosophila melanogaster	87-90
33224159-5	2020	In addition, the transgenic plants also show enhanced ROS scavenging activity, reduced ion leakage under salt stress, smaller stomatal opening, and more proline and soluble sugar accumulation, which demonstrate that UGT76C2 acts as an important player in abiotic stress response in rice.	ros	54-57	UDP-glucosyl transferase 76C2	Arabidopsis thaliana	216-223
30918581-2	2019	The activation of NLRP3 inflammasome had been reported to be involved in neurodegenerative diseases, including postoperative cognitive change, and is closely related to mitochondrial ROS and mitophagy.	ros	183-186	NLR family, pyrin domain containing 3	Mus musculus	18-23
24292328-3	2013	In this study, BI-1-/- mice showed increased vulnerability to chronic mild stress accompanied by alterations in the size and morphology of the hippocampi, enhanced ROS accumulation and an ER stress response compared with BI-1+/+ mice.	ros	164-167	transmembrane BAX inhibitor motif containing 6	Mus musculus	15-19
33154451-6	2020	Mechanistically, riboflavin prevented mitochondrial perturbations, such as mitochondrial ROS production and mitochondrial DNA release, which trigger the NLRP3 inflammasome assembly.	ros	89-92	NLR family, pyrin domain containing 3	Mus musculus	153-158
23271616-5	2013	L-NAME treatment increases the contribution of 5-lipoxygenase and NADPH oxidase to ROS/RNS production in the aorta, while taxifolin (100 mug/kg/day) decreases the contribution of these enzymes to the normal level.	ros	83-86	arachidonate 5-lipoxygenase	Rattus norvegicus	47-61
30716067-8	2019	We further found that PPARalpha improved mitochondrial efficiency in DR, and decreased ROS production and cell death in cultured retinal neurons.	ros	87-90	peroxisome proliferator activated receptor alpha	Rattus norvegicus	22-31
30584981-0	2019	Particulate matter induces inflammatory cytokine production via activation of NFkappaB by TLR5-NOX4-ROS signaling in human skin keratinocyte and mouse skin.	ros	100-103	toll like receptor 5	Homo sapiens	90-94
30584981-5	2019	Furthermore, PM2.5 induced a direct interaction between TLR5 and NOX4, and in turn induced the production of ROS and activated NFkappaB-IL-6 downstream, which was prevented by siRNA-mediated knockdown of NOX4 or antioxidant treatment.	ros	109-112	toll-like receptor 5	Mus musculus	56-60
33049446-5	2020	Under salt stress, the SlSOS1/2 and SlNHX1 genes were highly expressed, and the accumulation of Na+ was lower in the transgenic seedlings than in WT, however, ROS accumulated to a greater degree in the former, and the ROS-scavenging-related enzyme activities and AsA content were lower in the transgenic seedlings than WT.	ros	159-162	plasmalemma Na+/H+ antiporter	Solanum lycopersicum	23-31
30626741-3	2019	In this report, we demonstrate a critical role for the mitochondrial NAD+-dependent deacetylase, sirtuin-3 (SIRT3), in regulating macrophage mitochondrial bioenergetics, ROS formation, and proinflammatory responses.	ros	170-173	sirtuin 3	Mus musculus	97-106
30626741-3	2019	In this report, we demonstrate a critical role for the mitochondrial NAD+-dependent deacetylase, sirtuin-3 (SIRT3), in regulating macrophage mitochondrial bioenergetics, ROS formation, and proinflammatory responses.	ros	170-173	sirtuin 3	Mus musculus	108-113
23911537-7	2013	Therefore, we concluded that when mitochondrial DNA damages accumulate due to increased levels of ROS, rpS3 accumulates in the mitochondria to repair damaged DNA due to the decreased interaction between rpS3 and HSP90 in the cytosol.	ros	98-101	heat shock protein 90 alpha family class A member 1	Homo sapiens	212-217
33049446-5	2020	Under salt stress, the SlSOS1/2 and SlNHX1 genes were highly expressed, and the accumulation of Na+ was lower in the transgenic seedlings than in WT, however, ROS accumulated to a greater degree in the former, and the ROS-scavenging-related enzyme activities and AsA content were lower in the transgenic seedlings than WT.	ros	218-221	plasmalemma Na+/H+ antiporter	Solanum lycopersicum	23-31
33194004-12	2020	In cultured human renal tubular epithelial cell line (HK-2 cells), DEX inhibited LPS-induced apoptosis and generation of ROS, but this was reversed by overexpression of p75NTR.	ros	121-124	nerve growth factor receptor	Homo sapiens	169-175
24060899-2	2013	Chronic interleukin-17 (IL-17) increases blood pressure, autoantibodies (angiotensin II type I receptor [AT1-AA]), and ROS during pregnancy.	ros	119-122	interleukin 17A	Rattus norvegicus	8-22
24060899-2	2013	Chronic interleukin-17 (IL-17) increases blood pressure, autoantibodies (angiotensin II type I receptor [AT1-AA]), and ROS during pregnancy.	ros	119-122	interleukin 17A	Rattus norvegicus	24-29
30355620-7	2019	Silencing of PIN1 damaged basal mitochondrial function by significantly increasing intracellular ROS.	ros	97-100	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	13-17
33026807-0	2020	Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.	ros	72-75	peroxiredoxin 5	Homo sapiens	43-47
30552096-0	2019	APOPT1/COA8 assists COX assembly and is oppositely regulated by UPS and ROS.	ros	72-75	cytochrome c oxidase assembly factor 8	Homo sapiens	0-6
30400006-7	2019	We demonstrated that ATM deficiency shunted the glucose flux to aerobic glycolysis by upregulating LDHA expression, which generated more lactate and produced less mitochondrial ROS to promote CRPC cell growth.	ros	177-180	ATM serine/threonine kinase	Homo sapiens	21-24
30400006-8	2019	Inhibition of LDHA by siRNA or inhibitor FX11 generated less lactate and accumulated more ROS in ATM-deficient CRPC cells and therefore potentiated the cell death of ATM-deficient CRPC cells.	ros	90-93	ATM serine/threonine kinase	Homo sapiens	97-100
30439413-7	2019	On the other hand, cyclo(His-Pro)-mediated ROS attenuation, not linked to Nrf2 activation in this cellular model, is ascribed to increased soluble SOD1 activity due to the up-regulation of Hsp70 and Hsp27 expression.	ros	43-46	heat shock protein family B (small) member 1	Homo sapiens	199-204
24002177-5	2013	Knockdown of 14-3-3epsilon expression in turn further aggravated PC12 cell damage, such as an enhancement of ROS formation, and a reduction of cell viability and ATP production.	ros	109-112	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	Rattus norvegicus	13-26
23852084-8	2013	The expression levels of pro-inflammatory cytokines (MCP-1, TNF-alpha and IL-6) and ROS-related genes (NADPH p47 subunit and transcriptional factor PU.1) in adipose tissues and livers were analyzed using real-time RT-PCR.	ros	84-87	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	109-112
32788068-9	2020	Additionally, overproduction of reactive oxidative stress (ROS) and subsequent activation of ROS/p38MAPK under CKD milieus contribute to these series of outcomes, as scavenging ROS with N-acety-l-cysteine (NAC) or inhibiting p38MAPK signal pathway with SB203580 could inhibit CKD-induced activation of ROS/p38MAPK, increased expression of lamin B1, abnormality of nuclear membrane structure and VSMCs senescence.	ros	59-62	lamin B1	Homo sapiens	339-347
23921556-9	2013	Unexpectedly, PERK silencing in these cells reduced ROS production, normalized mitochondrial calcium, and improved mitochondrial morphology.	ros	52-55	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	14-18
30394045-7	2018	In addition, inhibitors of the ROS scavenging enzyme induced expression of the ATG1 and ATG8 genes by increasing the levels of H2O2 and O2 -.	ros	31-34	serine/threonine protein kinase ATG1	Saccharomyces cerevisiae S288C	79-83
32788068-9	2020	Additionally, overproduction of reactive oxidative stress (ROS) and subsequent activation of ROS/p38MAPK under CKD milieus contribute to these series of outcomes, as scavenging ROS with N-acety-l-cysteine (NAC) or inhibiting p38MAPK signal pathway with SB203580 could inhibit CKD-induced activation of ROS/p38MAPK, increased expression of lamin B1, abnormality of nuclear membrane structure and VSMCs senescence.	ros	93-96	lamin B1	Homo sapiens	339-347
32788068-9	2020	Additionally, overproduction of reactive oxidative stress (ROS) and subsequent activation of ROS/p38MAPK under CKD milieus contribute to these series of outcomes, as scavenging ROS with N-acety-l-cysteine (NAC) or inhibiting p38MAPK signal pathway with SB203580 could inhibit CKD-induced activation of ROS/p38MAPK, increased expression of lamin B1, abnormality of nuclear membrane structure and VSMCs senescence.	ros	93-96	lamin B1	Homo sapiens	339-347
33051434-7	2020	Interestingly, we found that the beta2-AR blockade affects Nrf2-Keap1 stability and its nuclear translocation leading to a drastic ROS increase and oxidative stress.	ros	131-134	adenosine A2a receptor	Homo sapiens	33-41
32599142-11	2020	In conclusion, we approved that oxidative stress induced ROS production promote the process of NP degeneration by enhancing KMT2D mediated transcriptional regulation of matrix degeneration related genes during NP degeneration.	ros	57-60	lysine methyltransferase 2D	Homo sapiens	124-129
30636894-10	2019	Mechanistic investigations revealed that the oncogenic effect of MARCH5 was mainly mediated by increased mitochondrial fission and subsequent ROS production in BC cells.	ros	142-145	membrane associated ring-CH-type finger 5	Homo sapiens	65-71
23619996-5	2013	Upon exposure to MSU or other ROS-mobilizing stimuli (rotenone and gamma-radiation), DNA fragmentation was markedly ameliorated in Nlrp3(-/-) and casp-1(-/-) DCs compared with WT DCs.	ros	30-33	NLR family, pyrin domain containing 3	Mus musculus	131-136
23619996-6	2013	Moreover, Nlrp3(-/-) DCs experienced significantly less oxidative DNA damage mediated by ROS.	ros	89-92	NLR family, pyrin domain containing 3	Mus musculus	10-15
23602911-8	2013	These results strongly suggest that cellular generation of ROS/RNS plays an important role in arsenite inhibition of PARP-1 activity, leading to the loss of PARP-1 DNA-binding ability and enzymatic activity.	ros	59-62	FAM20C golgi associated secretory pathway kinase	Homo sapiens	63-66
30261287-11	2018	Silencing TXNIP or ROS scavenger restored the high glucose induced reduction of Wnt/beta-catenin activity in HUVECs.	ros	19-22	wingless-type MMTV integration site family, member 3A	Mus musculus	80-83
32931733-4	2020	By constructing mitochondria-targeting nanoparticles, we observe that Steatohepatitis-associated circRNA ATP5B Regulator (SCAR), which is located in mitochondria, inhibits mitochondrial ROS (mROS) output and fibroblast activation.	ros	186-189	ribosomal protein S4 X-linked	Homo sapiens	70-120
32931733-4	2020	By constructing mitochondria-targeting nanoparticles, we observe that Steatohepatitis-associated circRNA ATP5B Regulator (SCAR), which is located in mitochondria, inhibits mitochondrial ROS (mROS) output and fibroblast activation.	ros	186-189	ribosomal protein S4 X-linked	Homo sapiens	122-126
30268890-10	2018	The transcription factor, NFkappaB, known to be activated by ROS, was shown to be involved in the increase in iNOS expression.	ros	61-64	inositol-3-phosphate synthase 1	Homo sapiens	110-114
24187829-11	2013	Moreover, PAG and CSE siRNA induced increased ROS generation and depletion of the critical antioxidant GSH and recombinant plasmid pcDNA 3.1/myc-His(-)-CSE rescued the level of ROS and GSH.	ros	46-49	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	18-21
32925168-4	2020	High surface thiol density and elevated expression of the ROS scavenger thioredoxin (Trx1) protected NK cells from ROS.	ros	58-61	thioredoxin	Homo sapiens	72-83
24187829-11	2013	Moreover, PAG and CSE siRNA induced increased ROS generation and depletion of the critical antioxidant GSH and recombinant plasmid pcDNA 3.1/myc-His(-)-CSE rescued the level of ROS and GSH.	ros	177-180	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	18-21
24187829-11	2013	Moreover, PAG and CSE siRNA induced increased ROS generation and depletion of the critical antioxidant GSH and recombinant plasmid pcDNA 3.1/myc-His(-)-CSE rescued the level of ROS and GSH.	ros	177-180	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	152-155
32925168-4	2020	High surface thiol density and elevated expression of the ROS scavenger thioredoxin (Trx1) protected NK cells from ROS.	ros	58-61	thioredoxin	Homo sapiens	85-89
32925168-4	2020	High surface thiol density and elevated expression of the ROS scavenger thioredoxin (Trx1) protected NK cells from ROS.	ros	115-118	thioredoxin	Homo sapiens	72-83
32925168-4	2020	High surface thiol density and elevated expression of the ROS scavenger thioredoxin (Trx1) protected NK cells from ROS.	ros	115-118	thioredoxin	Homo sapiens	85-89
32445781-6	2020	DJ-1 overexpression by pcDNA.3.1-DJ-1 transfection elevated cell viability while it inhibited LDH leakage, cell apoptosis, caspase-3 activity, ROS level, and MDA contents, while knockdown of DJ-1 has the opposite results.	ros	143-146	Parkinsonism associated deglycase	Homo sapiens	0-4
23686713-2	2013	Lectin-like oxidized low-density lipoprotein receptor (LOX)-1 is known to be an endothelial receptor of oxidized low-density lipoprotein, which is assumed to play a role in the initiation of ROS generation.	ros	191-194	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	0-61
23834359-4	2013	Specific inhibition of caspase-9 allows for efficient release of cytochrome c, but blocks changes in mitochondrial morphology and ROS production.	ros	130-133	caspase 9	Homo sapiens	23-32
23834359-5	2013	We show that caspase-9 can cleave Bid into tBid at amino acid 59 and that this cleavage of Bid is required for ROS production following serum withdrawal.	ros	111-114	caspase 9	Homo sapiens	13-22
23834359-8	2013	CONCLUSIONS: Taken together, these data suggest that caspase-9 is required for mitochondrial morphological changes and ROS production by cleaving and activating Bid into tBid.	ros	119-122	caspase 9	Homo sapiens	53-62
23834359-9	2013	After activation by caspase-9, caspase-3 inhibits ROS production and is required for efficient execution of apoptosis, while effector caspase-7 is required for apoptotic cell detachment.	ros	50-53	caspase 9	Homo sapiens	20-29
23837608-8	2013	Interestingly, insulin-induced ROS was found responsible for PKM2 activity reduction.	ros	31-34	pyruvate kinase M1/2	Homo sapiens	61-65
32650027-6	2020	Western blotting analysis, light-scattering study, DCF-DA assay and paralysis experiment indicated that SD-1 suppressed the formation of Cu2+-Abeta species, alleviated the Cu2+-Abeta species induced neurotoxicity and inhibited the production of ROS catalyzed by Cu2+-Abeta species in SH-SY5Y cells over-expressing the Swedish mutant form of human APP (APPsw SH-SY5Y) and Abeta42 transgenic C elegans (CL2020).	ros	245-248	CUP2Q35	Homo sapiens	104-108
32338108-5	2020	UDPGT).The intestinal microbiome plays a significant role in the ethanol biotransformation and in the initiation and progression of liver diseases stimulated by ethanol and its metabolite - acetaldehyde, or by lipopolysaccharide and ROS.	ros	233-236	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	0-5
23583906-1	2013	To find out whether and how the adenine nucleotide translocator-1 (ANT-1) inhibition due to NH2htau and Abeta1-42 is due to an interplay between these two Alzheimer"s peptides, ROS and ANT-1 thiols, use was made of mersalyl, a reversible alkylating agent of thiol groups that are oriented toward the external hydrophilic phase, to selectively block and protect, in a reversible manner, the -SH groups of ANT-1.	ros	177-180	solute carrier family 25 member 4	Homo sapiens	32-65
23583906-1	2013	To find out whether and how the adenine nucleotide translocator-1 (ANT-1) inhibition due to NH2htau and Abeta1-42 is due to an interplay between these two Alzheimer"s peptides, ROS and ANT-1 thiols, use was made of mersalyl, a reversible alkylating agent of thiol groups that are oriented toward the external hydrophilic phase, to selectively block and protect, in a reversible manner, the -SH groups of ANT-1.	ros	177-180	solute carrier family 25 member 4	Homo sapiens	67-72
32816608-7	2020	Also, MACC1-AS1 overexpression obviously increased the levels of GLUT1, HK2, G6PD, MCT1, ATP, lactate and NAPDH as well as promoted the activities of HK2 and LDHA, while reduced ROS level and the ratio of NADP+/NAPDH.	ros	178-181	MET transcriptional regulator MACC1	Homo sapiens	6-11
23727581-6	2013	We found that a selective inhibitor for RIPK1, necrostatin-1 (Nec-1) significantly blocked TNFalpha-induced cell death and ROS accumulation in NF-kappaB activation-deficient cells.	ros	123-126	receptor interacting serine/threonine kinase 1	Homo sapiens	40-45
23727581-9	2013	However, Nec-1, but not BHA, inhibited TNFalpha-induced phosphorylation of RIPK1 in these cells, suggesting that ROS play a crucial role in execution of necroptosis downstream of RIPK1 activation.	ros	113-116	receptor interacting serine/threonine kinase 1	Homo sapiens	75-80
32615411-8	2020	Transfection with PKCalpha siRNA and preincubation with the ROS scavenger (N-acetyl-cysteine, NAC), an inhibitor of NADPH oxidase (diphenyleneiodonium, DPI), or the mitochondria-specific superoxide scavenger (MitoTEMPO) inhibited PM-mediated inflammatory responses.	ros	60-63	synuclein alpha	Homo sapiens	94-97
23535216-6	2013	In addition, we detected the mRNA expression of ucp-2 and bcl-2, which are located at the mitochondrial inner membrane and related to reactive oxidative species (ROS) production.	ros	162-165	uncoupling protein 2	Danio rerio	48-53
32898015-0	2020	SIRT3 Ablation Deteriorates Obesity-Related Cardiac Remodeling by Modulating ROS-NF-kappaB-MCP-1 Signaling Pathway.	ros	77-80	sirtuin 3	Mus musculus	0-5
23862384-2	2013	This analysis of literature source allowed to authors affirms that signaling system of postconditioning can involve kinases: PKC, PI3K, Akt, MEKl/2, ERK1/2, MTOR, p70s6K, GSK3b, PKG and also eNOS, NO, GC, motoKATP channel, ROS, MPT pore.	ros	223-226	protein kinase cGMP-dependent 1	Homo sapiens	178-181
32898015-8	2020	Furthermore, significantly high levels of cardiac MCP-1 expression and macrophage infiltration, and ROS generation and activated NF-kappaB were observed in HFD-fed SIRT3-KO mice.	ros	100-103	sirtuin 3	Mus musculus	164-169
32898015-9	2020	We presumed that SIRT3 ablation-mediated MCP-1 upregulation is attributed to ROS-NF-kappaB activation.	ros	77-80	sirtuin 3	Mus musculus	17-22
23376140-5	2013	ROS produced by this oxidase activates Src, enable that in turn, transactivates EGFR that activates Stat3 in tyrosine, allowing its dimerization.	ros	0-3	Rous sarcoma oncogene	Mus musculus	39-42
23376140-5	2013	ROS produced by this oxidase activates Src, enable that in turn, transactivates EGFR that activates Stat3 in tyrosine, allowing its dimerization.	ros	0-3	epidermal growth factor receptor	Mus musculus	80-84
32898015-10	2020	Thus, we concluded that SIRT3 prevents obesity-related cardiac remodeling by attenuating cardiac inflammation and fibrosis, through modulation of ROS-NF-kappaB-MCP-1 pathway.	ros	146-149	sirtuin 3	Mus musculus	24-29
23271700-1	2013	A point mutation in the mouse Ncf1(m1J) gene decreases production of ROS by the phagocytic NOX2 complex.	ros	69-72	neutrophil cytosolic factor 1	Mus musculus	30-38
32943819-7	2020	As a result, SOS5 gene in synergy with ABA, scavenge the ROS by stimulating antioxidant system, leads to an increase in stress related gene expressions and thus contributes to salinity tolerance.	ros	57-60	Fasciclin-like arabinogalactan family protein	Arabidopsis thaliana	13-17
23271700-3	2013	Our aim was to investigate whether the mutant p47phox, lacking 8 aa, is active, but as a result of its low expression, ROS production is decreased in Ncf1(m1J) mice, or whether the mutant p47phox completely lacks the capability to activate the NOX2 complex.	ros	119-122	neutrophil cytosolic factor 1	Mus musculus	46-53
23271700-3	2013	Our aim was to investigate whether the mutant p47phox, lacking 8 aa, is active, but as a result of its low expression, ROS production is decreased in Ncf1(m1J) mice, or whether the mutant p47phox completely lacks the capability to activate the NOX2 complex.	ros	119-122	neutrophil cytosolic factor 1	Mus musculus	150-158
32771153-5	2020	Overexpression of TaEXPA2 enhanced the antioxidant capacity in wheat plants, via elevation of antioxidant enzyme activity and the increase of the transcripts of some ROS scavenging enzyme-related genes.	ros	166-169	expA2	Triticum aestivum	18-25
23247009-4	2013	In addition, BGG-mediated inhibition of AR prevented LPS-induced activation of JNK and p38 and lowered ROS levels, which could inhibit LPS-induced apoptosis.	ros	103-106	aldo-keto reductase family 1, member B3 (aldose reductase)	Mus musculus	40-42
32808001-6	2020	Further investigations reveal that FNs could effectively inhibit the activation of NLRP3 (NACHT, LRR and PYD domains-containing protein 3) inflammasome, and thus prevent the secretion of mature IL-1beta and neutrophil influx, deriving from the superior ROS scavenging capability.	ros	253-256	NLR family, pyrin domain containing 3	Mus musculus	83-88
23290263-5	2013	We found that lercanidipine and labedipinedilol-A attenuated production of NO, ROS and TNF-alpha from LPS/IFN-gamma-stimulated VSMCs.	ros	79-82	interferon gamma	Rattus norvegicus	106-115
32848720-8	2020	Moreover, our results demonstrated that 1alpha,25(OH)2D3 promoted the ROS level via activating NADPH oxidase complexes, NOX4, p22phox, and p47phox.	ros	70-73	neutrophil cytosolic factor 1	Mus musculus	139-146
22903504-8	2013	Notably, LPS-induced ROS generation can partly facilitate p38 MAPK/JNK/AKT activation to regulate GSK-3beta-mediated Mcl-1 stability, apoptosis, and neutrophilia.	ros	21-24	glycogen synthase kinase 3 beta	Mus musculus	98-107
23063593-6	2013	Furthermore, the addition of a ROS inhibitor (N-Acetyl-l-cysteine, NAC) significantly attenuated the apoptosis induced by HER and also blocked the expression of PGC-1alpha protein.	ros	31-34	synuclein alpha	Homo sapiens	67-70
32416091-14	2020	CONCLUSION: Suppression of ACE and AP-N expression mediates congenital UPJO pathogenesis by repressing renal tubular epithelial proliferation, promoting ROS production, and enhancing inflammatory factor expression.	ros	153-156	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	27-30
32470468-0	2020	Metformin protects against ischaemic myocardial injury by alleviating autophagy-ROS-NLRP3-mediated inflammatory response in macrophages.	ros	80-83	NLR family, pyrin domain containing 3	Mus musculus	84-89
32774667-6	2020	Go6976, GSK2795039, and NAC were used to inhibit PKC-alpha, NOX2, and ROS, respectively.	ros	70-73	synuclein alpha	Homo sapiens	24-27
23819014-6	2013	Although signaling via PI3K, Sirt1, AMPK, ROS, and Nrf2 appeared to play a significant role in the modulation of PAI-1 gene expression under noninflammatory conditions, those signaling components were not involved in mediating the resveratrol effects on PAI-1 production under inflammatory conditions.	ros	42-45	serpin family E member 1	Homo sapiens	113-118
32376267-0	2020	Heme oxygenase-1 alleviated non-alcoholic fatty liver disease via suppressing ROS-dependent endoplasmic reticulum stress.	ros	78-81	heme oxygenase 1	Homo sapiens	0-16
32733468-10	2020	This effect was reversed by NOX5 inhibition, but not NOX2, resulting in suppression of NOX5-dependent ROS production.	ros	102-105	NADPH oxidase 5	Homo sapiens	87-91
24089630-6	2013	Indeed, deletion of HXK2 causes an increase of apoptotic cells with several morphological and biochemical changes that are typical of apoptosis, including DNA fragmentation, externalization of phosphatidylserine, and ROS production.	ros	217-220	hexokinase 2	Saccharomyces cerevisiae S288C	20-24
30320378-7	2018	At the molecular level, the reintroduction of Mst1 in A549 cells led to activation of mitochondrial apoptosis, as evidenced by a reduction in mitochondrial potential, overproduction of ROS, cytochrome c release from the mitochondria into the nucleus, and upregulation of pro-apoptotic protein expression.	ros	185-188	macrophage stimulating 1	Homo sapiens	46-50
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	31-34	glutathione S-transferase pi 1	Homo sapiens	108-113
23219970-3	2013	In this study we observed that the CB1 and CB2 receptor non-selective or selective agonists dramatically attenuate iNOS induction and ROS generation in LPS-activated microglia.	ros	134-137	cannabinoid receptor 2	Homo sapiens	43-46
32526700-3	2020	Here we show that C/EBPbeta, a ROS responsive transcription factor, regulates the transcription of NQO1 and GSTP1, two antioxidative reductases, which neutralize ROS in the GBM and mediates their proliferation.	ros	162-165	glutathione S-transferase pi 1	Homo sapiens	108-113
30357139-6	2018	The complete eradication of preformed biofilm was achieved when treated with 10 mug mL-1 of GAPP for 5 h. The GAPP exerted bactericidal and biofilm inhibition activity through a "contact-kill-release" mode of action, wherein the electrostatic interaction of GAPP with the bacterial cells induced physical disruption accompanied by ROS-mediated biochemical changes.	ros	331-334	L1 cell adhesion molecule	Mus musculus	84-102
32605179-4	2020	Consistently, seedlings mutating two major ROS-generating enzyme genes, respiratory burst oxidase homologs D and F (RBOHD and RBOHF), abolished the root ROS accumulation and impaired the growth inhibition of the roots induced by Pep1.	ros	43-46	respiratory burst oxidase protein F	Arabidopsis thaliana	126-131
23326634-2	2013	LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 and ROS-dependent phenomena.	ros	22-25	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	150-155
32605179-4	2020	Consistently, seedlings mutating two major ROS-generating enzyme genes, respiratory burst oxidase homologs D and F (RBOHD and RBOHF), abolished the root ROS accumulation and impaired the growth inhibition of the roots induced by Pep1.	ros	153-156	respiratory burst oxidase protein F	Arabidopsis thaliana	126-131
23326634-2	2013	LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 and ROS-dependent phenomena.	ros	160-163	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	0-5
32432601-0	2020	Pelargonidin ameliorates CCl4-induced liver fibrosis by suppressing the ROS-NLRP3-IL-1beta axis via activating the Nrf2 pathway.	ros	72-75	C-C motif chemokine ligand 4	Homo sapiens	25-29
29746885-6	2018	In mouse primary HSCs, curcumin prevented succinate- and CoCl2-induced hypoxia-inducible transcription factor-1alpha (HIF-1alpha) induction via suppression of ROS production and effectively reduced gene expressions of Col1alpha, Col3alpha, fibronectin and TGF-beta1 with inflammation inhibition.	ros	159-162	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-128
30145470-0	2018	4-Methylcatechol prevents streptozotocin-induced acute kidney injury through modulating NGF/TrkA and ROS-related Akt/GSK3beta/beta-catenin pathways.	ros	101-104	catenin beta 1	Homo sapiens	126-138
32432601-0	2020	Pelargonidin ameliorates CCl4-induced liver fibrosis by suppressing the ROS-NLRP3-IL-1beta axis via activating the Nrf2 pathway.	ros	72-75	interleukin 1 alpha	Homo sapiens	82-90
22378505-2	2012	ART treatment induced ROS-mediated apoptosis in a concentration- and time-dependent fashion accompanying the loss of mitochondrial potential and subsequent release of Smac and AIF indicative of intrinsic apoptosis pathway.	ros	22-25	diablo IAP-binding mitochondrial protein	Homo sapiens	167-171
32449069-5	2020	Our present review demonstrates that ROS dependent regulation of Nrf-2 is one of the most important determinants of E2 regulation by altering SULT1E1 expression.	ros	37-40	sulfotransferase family 1E member 1	Homo sapiens	142-149
22886911-5	2012	In earlier studies, we found that PRODH/POX functions as a tumor suppressor to initiate apoptosis, inhibit tumor growth, and block the cell cycle, all by ROS signaling.	ros	154-157	proline dehydrogenase 1	Homo sapiens	34-39
30259128-9	2018	The oncogenic mechanism involves a ROS-activated AKT/FOXO1/TWIST1 signaling pathway.	ros	35-38	forkhead box O1	Mus musculus	53-58
29427171-6	2018	CORD6 is caused firstly by lowered basal and GCAP1-dependent ROS-GC1 activity and secondly, by a shift in Ca2+ sensitivity of the ROS-GC1/GCAP1 complex that remains active in darkness.	ros	61-64	guanylate cyclase 2D, retinal	Homo sapiens	0-5
32179110-5	2020	After that, QDs-induced excessive ROS generation triggered the NLRP3 inflammasome activation and resulted in active caspase-1 to process pro-IL-1ss into mature IL-1ss release and inflammatory cell death, i.e. pyroptosis.	ros	34-37	NLR family, pyrin domain containing 3	Mus musculus	63-68
30382081-5	2018	Mechanistically, Cbl decreases the level of phosphorylated Pyk2 (p-Pyk2) through ubiquitination-mediated proteasomal degradation and reduces mitochondrial ROS (mtROS) production by contributing to the maintenance of mitochondrial size.	ros	155-158	Casitas B-lineage lymphoma	Mus musculus	17-20
22886911-5	2012	In earlier studies, we found that PRODH/POX functions as a tumor suppressor to initiate apoptosis, inhibit tumor growth, and block the cell cycle, all by ROS signaling.	ros	154-157	proline dehydrogenase 1	Homo sapiens	40-43
22886911-9	2012	Under metabolic stress such as oxygen and glucose deprivation, PRODH/POX can be induced to serve as a tumor survival factor through ATP production or ROS-induced autophagy.	ros	150-153	proline dehydrogenase 1	Homo sapiens	63-68
22886911-9	2012	Under metabolic stress such as oxygen and glucose deprivation, PRODH/POX can be induced to serve as a tumor survival factor through ATP production or ROS-induced autophagy.	ros	150-153	proline dehydrogenase 1	Homo sapiens	69-72
22822009-6	2012	We found that enhanced capacity for ROS production is, in part, a result of increased protein expression of gp91(phox) and p22(phox) but also demonstrate that IFN-gamma induced a shift in the predominant localization of gp91(phox) and p22(phox) from intracellular membrane compartments to the PM.	ros	36-39	paired Ig-like receptor B	Mus musculus	108-112
22822009-6	2012	We found that enhanced capacity for ROS production is, in part, a result of increased protein expression of gp91(phox) and p22(phox) but also demonstrate that IFN-gamma induced a shift in the predominant localization of gp91(phox) and p22(phox) from intracellular membrane compartments to the PM.	ros	36-39	paired Ig-like receptor B	Mus musculus	220-224
32486485-7	2020	Exogenous alpha-Syn treatment led to P2X7R-dependent decrease in mitochondrial membrane potential as well as elevation of mitochondrial ROS production resulting in breakdown of cellular energy production.	ros	136-139	synuclein alpha	Homo sapiens	10-19
22843056-7	2012	Silencing of SlVRSLip in R plants led to the collapse of resistance upon TYLCV inoculation and to a necrotic response along the stem and petioles accompanied by ROS production.	ros	161-164	virus resistant/susceptible lipocalin	Solanum lycopersicum	13-21
22753949-0	2012	Transient receptor potential vanilloid 1 activation induces autophagy in thymocytes through ROS-regulated AMPK and Atg4C pathways.	ros	92-95	autophagy related 4C, cysteine peptidase	Mus musculus	115-120
22753949-4	2012	CPS specifically increased Atg4C mRNA expression and induced oxidation of Atg4C protein by ROS generation.	ros	91-94	autophagy related 4C, cysteine peptidase	Mus musculus	74-79
29953890-7	2018	MP1 could also effectively protect RAW264.7 cells from H2O2-induced injury by maintaining stable cell viability, decreasing ROS, MDA and LDH level and enhancing SOD, GSH-Px and CAT activity.	ros	124-127	pitrilysin metallepetidase 1	Mus musculus	0-3
32550919-0	2020	Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.	ros	94-97	NLR family, pyrin domain containing 3	Mus musculus	108-113
30217448-8	2018	In palmitate (PA)-treated primary cardiomyocytes, Tmbim1 ablation markedly enhanced cell inflammation and oxidative stress, which were abolished by the suppression of ROS generation and NF-kappaB activation.	ros	167-170	transmembrane BAX inhibitor motif containing 1	Mus musculus	50-56
22787054-7	2012	Moreover, stressed brains markedly upregulated the expression of p47phox to weak restress evoked in the poststress period, and this molecular response was reminiscent of amplified ROS surge to restress.	ros	180-183	neutrophil cytosolic factor 1	Mus musculus	65-72
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	0-3	caspase 9	Homo sapiens	91-100
29527928-4	2018	Subsequently, the mitochondria-mediated apoptosis of keloid fibroblasts was restrained by miR-21 over-expression, as evidenced by enhanced mitochondrial membrane potential and decreased production of mitochondrial ROS.	ros	214-217	microRNA 21	Homo sapiens	90-96
32454932-0	2020	CpG-Oligodeoxynucleotides Alleviate Tert-Butyl Hydroperoxide-Induced Macrophage Apoptosis by Regulating Mitochondrial Function and Suppressing ROS Production.	ros	143-146	telomerase reverse transcriptase	Mus musculus	36-40
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	107-110	caspase 9	Homo sapiens	91-100
22739161-7	2012	ROS, CaMKII, MAPKK, JNK1/2 and P38 inhibitors decreased the levels of activated caspase 3, caspase 9 by GA.ROS, CaMKII, MAPKK, JNK1/2 inhibitors decreased the levels of p-JNK by GA. ROS, CaMKII, MAPKK, P38 inhibitors decreased the levels of P38 by GA.	ros	107-110	caspase 9	Homo sapiens	91-100
30319655-5	2018	Knockdown of ceruloplasmin would elicit more severe ROS damage, leading to cell death in the presence of H2O2, which induced Nrf2 cascade and the recovery of ceruloplasmin to mediate spontaneous tolerance.	ros	52-55	ceruloplasmin	Homo sapiens	13-26
32454932-4	2020	We used the imaging flow cytometry to demonstrate that tert-butyl hydroperoxide (t-BHP) induces mitochondrial-mediated apoptosis and ROS production in RAW264.7 cells.	ros	133-136	telomerase reverse transcriptase	Mus musculus	55-59
22508836-5	2012	These cellular responses delay apoptotic cell death by inducing the IRE1alpha-XBP-1 pathway in conjunction with ROS-mediated mTOR inhibition.	ros	112-115	X-box binding protein 1	Homo sapiens	78-83
32124251-6	2020	Pathway analysis demonstrated that the ROS/Nrf2/HO-1-SOD2-NQO-1-GCLC signaling axis is a key axis through which curcumin activates the Nrf2/ARE pathway in TMJ inflammatory chondrocytes.	ros	39-42	heme oxygenase 1	Homo sapiens	48-57
30099254-10	2018	By various biochemical assays, this complex was found to effectively inhibit the thioredoxin reductase (TrxR) and its cytotoxicity towards prostate PC-3, bladder T24 and liver HepG2 cells was found to be ROS-dependent.	ros	204-207	peroxiredoxin 5	Homo sapiens	81-102
32352125-5	2020	Elevated lipid peroxide and decreased SOD activity by TBBQ exposure suggest the overproduction of ROS, which may account for the increase in the genotoxic stress protein p53.	ros	98-101	transformation related protein 53, pseudogene	Mus musculus	170-173
30099254-10	2018	By various biochemical assays, this complex was found to effectively inhibit the thioredoxin reductase (TrxR) and its cytotoxicity towards prostate PC-3, bladder T24 and liver HepG2 cells was found to be ROS-dependent.	ros	204-207	peroxiredoxin 5	Homo sapiens	104-108
22415872-7	2012	This ROS/Src/Erk pathway mechanism appeared to be the same route by which DM induced LPA resistance of retinal neovessels.	ros	5-8	Rous sarcoma oncogene	Mus musculus	9-12
22351695-9	2012	Gene expression profiling revealed two main mechanisms of action: PI3K/AKT inhibition and induction of ROS that resulted in an oxidative stress response through activating protein 1 (AP-1), c-jun-NH(2)-terminal kinase, and ATF3 culminating in the upregulation of NOXA.	ros	103-106	activating transcription factor 3	Homo sapiens	223-227
32027621-3	2020	In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow-derived macrophage cultures.	ros	87-90	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	26-29
22230367-1	2012	In this study, we explored the role of Bax inhibitor-1 (BI-1) on the expression of P450 2E1 and related ROS production.	ros	104-107	transmembrane BAX inhibitor motif containing 6	Mus musculus	39-54
22230367-1	2012	In this study, we explored the role of Bax inhibitor-1 (BI-1) on the expression of P450 2E1 and related ROS production.	ros	104-107	transmembrane BAX inhibitor motif containing 6	Mus musculus	56-60
22230367-11	2012	Our results suggest that the BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation.	ros	121-124	transmembrane BAX inhibitor motif containing 6	Mus musculus	29-33
22129765-2	2012	The apoferritin coating not only improves the biocompatibility and changes the cellular uptake route of nanoceria, but also manipulates the electron localization at the surface of the nanoparticle thereby ameliorating the ROS-scavenging activity.	ros	222-225	ferritin heavy chain 1	Homo sapiens	4-15
32027621-5	2020	Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function.	ros	191-194	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	154-157
32127259-5	2020	Subsequent flow cytometry based annexin-V and DCFHDA studies suggested that 8 could induce apoptosis through intracellular ROS-dependent pathway.	ros	123-126	annexin A5	Homo sapiens	32-41
22395403-9	2012	Our findings revealed that the possible mechanism of action of PAM protected against brain ischemia injury involves regulation of GLT-1, EAAC1 and ROS generation.	ros	147-150	peptidylglycine alpha-amidating monooxygenase	Rattus norvegicus	63-66
32328177-6	2020	Supplementation of cells with NAC (ROS Scavenger) effectively protected the cells from BLN-A-induced apoptosis.	ros	35-38	synuclein alpha	Homo sapiens	30-33
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	10-13	caspase 2	Homo sapiens	169-185
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	10-13	caspase 2	Homo sapiens	169-178
32256964-9	2020	In addition, autophagy inhibitors or NAC could counteract the effect of DpdtC and restore the level of p53 to the control group, indicating that the upregulation of p53 was caused by ferritinophagy-mediated ROS production.	ros	207-210	synuclein alpha	Homo sapiens	37-40
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	99-102	caspase 2	Homo sapiens	169-185
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	99-102	caspase 2	Homo sapiens	169-178
32174999-8	2020	Finally, Toll signaling activates JNK-mediated cell death through promoting ROS production.	ros	76-79	basket	Drosophila melanogaster	34-37
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	99-102	caspase 2	Homo sapiens	169-185
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	99-102	caspase 2	Homo sapiens	169-178
22002103-9	2012	Our results also suggest that ROS are critical regulators of the sequential activation of caspase-2 and -3 in nucleoside derivative-treated cancer cells.	ros	30-33	caspase 2	Homo sapiens	90-106
22095949-4	2012	Persistent activation of the Ang II receptor stimulated ROS-dependent phosphorylation of Src, leading to sustained EGFR-dependent signaling for TGFbeta expression.	ros	56-59	Rous sarcoma oncogene	Mus musculus	89-92
22095949-4	2012	Persistent activation of the Ang II receptor stimulated ROS-dependent phosphorylation of Src, leading to sustained EGFR-dependent signaling for TGFbeta expression.	ros	56-59	epidermal growth factor receptor	Mus musculus	115-119
32138149-6	2020	Two TrxR inhibitors, auranofin and [Au(d2pype)2]Cl, increased intracellular ROS levels and elicited apoptosis in both sensitive and imatinib resistant CML cells.	ros	76-79	peroxiredoxin 5	Homo sapiens	4-8
22239975-9	2012	Together, these data indicate there is a mechanism in human PBMCs where TLR4 activation by LPS leads to ROS generation through NOX4 and activation of the PI3K pathway.	ros	104-107	toll like receptor 4	Homo sapiens	72-76
31862471-5	2020	Differentially expressed proteins were studied and detailed biochemical analysis for selected proteins was performed.The effect of mitochondrial HXK-2 over-expression induced by p53 in sucrose grown cells on cell survival was evaluated using gene deletion/tagging, co-localisation and mitochondrial ROS detection.	ros	299-302	hexokinase 2	Saccharomyces cerevisiae S288C	145-150
22415079-2	2012	The HO-2 isozyme is essential for regulating physiological levels of ROS.	ros	69-72	heme oxygenase 2	Mus musculus	4-8
31862471-8	2020	CONCLUSIONS: Enhanced association of HXK2 with the mitochondria with the concomitant accumulation of G6PDG and 6PGDH results in increased NADPH that scavenges ROS and provides resistance to apoptosis.	ros	159-162	hexokinase 2	Saccharomyces cerevisiae S288C	37-41
21984036-10	2012	Our results show that PMA can induce MUC5AC expression by activation of the Duox1-ROS-TACE-TGF-alpha-EGFR signaling pathway.	ros	82-85	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	37-43
32106859-9	2020	Importantly, cisplatin and paclitaxel promote miR-522 secretion from CAFs by activating USP7/hnRNPA1 axis, leading to ALOX15 suppression and decreased lipid-ROS accumulation in cancer cells, and ultimately result in decreased chemo-sensitivity.	ros	157-160	microRNA 522	Homo sapiens	46-53
21833623-7	2011	Our results indicated that HO-1 counteracts oxidative imbalance reducing ROS levels.	ros	73-76	heme oxygenase 1	Homo sapiens	27-31
21859819-8	2011	In contrast, NO production was reduced, while endothelial NO synthase (eNOS)-dependent ROS production was increased in adult Alk1(+/-) mice.	ros	87-90	nitric oxide synthase 3, endothelial cell	Mus musculus	71-75
32106859-10	2020	CONCLUSIONS: The present study demonstrates that CAFs secrete exosomal miR-522 to inhibit ferroptosis in cancer cells by targeting ALOX15 and blocking lipid-ROS accumulation.	ros	157-160	microRNA 522	Homo sapiens	71-78
21859819-10	2011	CONCLUSION: The increased pulmonary vascular remodelling in Alk1(+/-) mice leads to signs of PH and is associated with eNOS-dependent ROS production, which is preventable by anti-oxidant treatment.	ros	134-137	nitric oxide synthase 3, endothelial cell	Mus musculus	119-123
32096759-5	2020	Moreover, independent of this activity, Trx1 is critical for NLRP3 inflammasome activation and IL-1b production in macrophages by detoxifying excessive ROS levels.	ros	152-155	NLR family, pyrin domain containing 3	Mus musculus	61-66
22099309-1	2011	Metabolic stress results in p53 activation, which can trigger cell-cycle arrest, ROS clearance, or apoptosis.	ros	81-84	transformation related protein 53, pseudogene	Mus musculus	28-31
22099309-7	2011	Starvation of mice where PGC-1alpha expression is abrogated results in loss of p53-mediated ROS clearance, enhanced p53-dependent apoptosis, and consequent severe liver atrophy.	ros	92-95	transformation related protein 53, pseudogene	Mus musculus	79-82
22055193-7	2011	Lpin1 expression in response to nutritional stress is controlled through the ROS-ATM-p53 pathway and is conserved in human cells.	ros	77-80	lipin 1	Homo sapiens	0-5
22055193-7	2011	Lpin1 expression in response to nutritional stress is controlled through the ROS-ATM-p53 pathway and is conserved in human cells.	ros	77-80	ATM serine/threonine kinase	Homo sapiens	81-84
32096765-5	2020	Besides, we provided evidence that C3k, an inhibitor of PKM2, caused increase in mitochondrial membrane potential and maintained low levels of ROS, and promoted mitochondrial fusion.	ros	143-146	pyruvate kinase M1/2	Homo sapiens	56-60
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	ros	81-84	TNF receptor superfamily member 10b	Homo sapiens	111-127
32214279-10	2020	Two apoptotic waves were observed at 12-24 h and at 72 h. The increase of ROS production, at 24 h until the end of the culture period, was accompanied by the induction, at 48 h, of redox-related Cat, Sod1, Sod2, Gpx1 and Gpx4 genes.	ros	74-77	glutathione peroxidase 1	Mus musculus	212-216
21854768-0	2011	Acrolein sensitizes human renal cancer Caki cells to TRAIL-induced apoptosis via ROS-mediated up-regulation of death receptor-5 (DR5) and down-regulation of Bcl-2.	ros	81-84	TNF receptor superfamily member 10b	Homo sapiens	129-132
32214279-10	2020	Two apoptotic waves were observed at 12-24 h and at 72 h. The increase of ROS production, at 24 h until the end of the culture period, was accompanied by the induction, at 48 h, of redox-related Cat, Sod1, Sod2, Gpx1 and Gpx4 genes.	ros	74-77	glutathione peroxidase 4	Mus musculus	221-225
32054977-6	2020	Integrative proteomic and functional analyses revealed nitroxoline-induced downregulation of Na/K-ATPase pump and beta-catenin, which associated with drastic impairment in cell growth, migration, invasion, increased ROS production and induction of DNA damage response.	ros	216-219	catenin beta 1	Homo sapiens	114-126
21669192-7	2011	Here, we demonstrated that IR-induced ROS activated cyclooxygenases-2 (COX-2) and 5-lipoxygenase (5-LOX) pathway in HFL-1 and MRC-5 cells.	ros	38-41	complement factor H related 1	Homo sapiens	116-121
30041041-10	2018	Notably, activation of HO-1 gene expression further increased the levels of EETs, suggesting that the antioxidant HO-1 system protects EETs from degradation by ROS.	ros	160-163	heme oxygenase 1	Homo sapiens	23-27
31672550-10	2020	These findings indicated that excessive ROS induced by the overexpression of TIPE1 in endothelial cells accelerated the process of atherogenesis.	ros	40-43	tumor necrosis factor, alpha-induced protein 8-like 1	Mus musculus	77-82
30041041-10	2018	Notably, activation of HO-1 gene expression further increased the levels of EETs, suggesting that the antioxidant HO-1 system protects EETs from degradation by ROS.	ros	160-163	heme oxygenase 1	Homo sapiens	114-118
31882909-11	2019	Nifedipine does not completely reduce VGVAPG peptide-activated ROS production, whereas MK-801, verapamil, and Src inhibitor reduce VGVAPG peptide-activated Ca2+ influx and ROS production.	ros	172-175	Rous sarcoma oncogene	Mus musculus	110-113
30157922-11	2018	Furthermore, the chemotherapy-induced niche perturbed the hematopoietic reconstitution of HSCs in our N-MYC-driven B-ALL mouse model by promoting HSCs to enter cell cycle and increasing intracellular ROS levels and mitochondrial membrane potential of HSCs, which lead to the cell apoptosis of HSCs.	ros	200-203	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	Mus musculus	102-107
21327864-2	2011	In this study we showed that ATO induced cell damage and heme oxygenase-1 (HO-1) expression in glioma cells via ROS generation.	ros	112-115	heme oxygenase 1	Homo sapiens	75-79
21327864-3	2011	HO-1 inducer clearly protected from ATO-induced cell death and ROS generation, and HO-1 inhibitor led to a significant increase in cell death and ROS generation induced by ATO.	ros	63-66	heme oxygenase 1	Homo sapiens	0-4
21327864-3	2011	HO-1 inducer clearly protected from ATO-induced cell death and ROS generation, and HO-1 inhibitor led to a significant increase in cell death and ROS generation induced by ATO.	ros	146-149	heme oxygenase 1	Homo sapiens	83-87
22108328-0	2011	Troglitazone induced apoptosis via PPARgamma activated POX-induced ROS formation in HT29 cells.	ros	67-70	proline dehydrogenase 1	Homo sapiens	55-58
22108328-1	2011	OBJECTIVE: In order to investigate the potential mechanisms in troglitazone-induced apoptosis in HT29 cells, the effects of PPARgamma and POX-induced ROS were explored.	ros	150-153	proline dehydrogenase 1	Homo sapiens	138-141
31885807-3	2019	Under oxidative stress, stromal cell differentiation was impaired, but this impairment was abrogated by rHB-EGF accompanied with the reduced levels of ROS and MDA which were regarded as the biomarkers for oxidative stress, indicating an antioxidant role of HB-EGF.	ros	151-154	heparin binding EGF like growth factor	Homo sapiens	105-111
21494253-6	2011	Additionally, ROS inhibition reduced AMD3100-induced SDF-1 release, activation of circulating uPA and mobilization of progenitor cells.	ros	14-17	proline-rich acidic protein 1	Mus musculus	94-97
21486680-0	2011	The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis.	ros	80-83	mitogen-activated protein kinase 8	Rattus norvegicus	94-97
30224925-0	2018	SYKT Alleviates Doxorubicin-Induced Cardiotoxicity via Modulating ROS-Mediated p53 and MAPK Signal Pathways.	ros	66-69	transformation related protein 53, pseudogene	Mus musculus	79-82
30224925-2	2018	Doxorubicin (DOX) is an effective therapeutic drug for malignant tumors; however, its clinical applications were limited by its side effects, especially the cardiotoxicity caused by ROS-mediated p53 and MAPK signal pathways" activation-induced cell apoptosis.	ros	182-185	transformation related protein 53, pseudogene	Mus musculus	195-198
30224925-5	2018	This study aimed at investigating whether SYKT alleviated DOX-induced cardiotoxicity by inhibiting ROS-mediated apoptosis and elucidating the role of ROS-mediated p53 and MAPK signal pathways" activation in this process.	ros	150-153	transformation related protein 53, pseudogene	Mus musculus	163-166
21640074-4	2011	Additionally, there is a close relationship between induction of APP and Abeta and intracellular accumulation of ROS along with loss of mitochondrial membrane potential followed by the death of RGC-5 cells in culture under hypoxia.	ros	113-116	amyloid beta (A4) precursor protein	Mus musculus	73-78
31511637-0	2019	Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	ros	72-75	toll like receptor 4	Homo sapiens	56-60
30224945-4	2018	H9C2 cells were treated with LPS to induce sepsis, and miR-146a overexpression significantly increased the cell viability, reduced the apoptosis and ROS level, and attenuated the release of proinflammatory cytokines including TNF-alpha and IL-1beta.	ros	149-152	microRNA 146a	Rattus norvegicus	55-63
21464611-11	2011	As with other agents that induce activation of the NLRP3 inflammasome, the ability of doxorubicin to provide proinflammatory danger signals was inhibited by co-treatment of cells with ROS inhibitors or by incubating cells in high extracellular potassium.	ros	184-187	NLR family, pyrin domain containing 3	Mus musculus	51-56
31392537-5	2019	The results showed that 6-OHDA significantly decreased cell viability, glutathione and pro-caspase-3 levels, and increased ROS, the amount of bax in PC12 cells, while the pretreatment with 5 muM vitamin K2 significantly decreased the cell death induced by 6-OHDA.	ros	123-126	BCL2 associated X, apoptosis regulator	Rattus norvegicus	142-145
21421046-0	2011	PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.	ros	97-100	PTEN induced putative kinase 1	Mus musculus	6-11
30898057-1	2019	OBJECTIVES: Protein phosphatase 2A (PP2A), a major serine/threonine phosphatase, is also known to be a target of ROS.	ros	113-116	protein phosphatase 2 phosphatase activator	Homo sapiens	36-41
21421046-8	2011	Overexpression of wild-type PINK1 restored hyperpolarized DeltaPsi(m) and thread-like mitochondrial morphology and inhibited ROS formation in PINK1-null dopaminergic cells.	ros	125-128	PTEN induced putative kinase 1	Mus musculus	28-33
21421046-11	2011	These results indicate that PINK1 is required for maintaining normal DeltaPsi(m) and mitochondrial morphology of cultured SN dopaminergic neurons and exerts its neuroprotective effect by inhibiting ROS formation.	ros	198-201	PTEN induced putative kinase 1	Mus musculus	28-33
21421046-12	2011	Our study also provides the evidence that PARK6 mutant (G309D), (E417G) or (CDelta145) PINK1 is defective in regulating mitochondrial functions and attenuating ROS production of SN dopaminergic cells.	ros	160-163	PTEN induced putative kinase 1	Mus musculus	87-92
30127666-16	2018	The augmented mitochondrial fission stimulated ROS overproduction, mediated redox imbalance, interrupted mitochondrial energy generation, reduced mitochondrial membrane potential, promoted leakage of the pro-apoptotic molecule cyt-c into the nucleus, and initiated caspase-9-related mitochondrial death.	ros	47-50	caspase 9	Homo sapiens	265-274
29922854-0	2018	fMLP-dependent activation of Akt and ERK1/2 through ROS/Rho A pathways is mediated through restricted activation of the FPRL1 (FPR2) receptor.	ros	52-55	formyl peptide receptor 2	Homo sapiens	120-125
29922854-0	2018	fMLP-dependent activation of Akt and ERK1/2 through ROS/Rho A pathways is mediated through restricted activation of the FPRL1 (FPR2) receptor.	ros	52-55	formyl peptide receptor 2	Homo sapiens	127-131
29922854-10	2018	CONCLUSION: Collectively, these data suggested that fMLP-activated ERK1/2 and Akt pathways through specific activation of the FPRL1/ROS/RoA-GTPase pathway.	ros	132-135	formyl peptide receptor 2	Homo sapiens	126-131
31100998-3	2019	RESULTS: VD3 prevented the increase in AChE in groups of VD42 microg/kg and VD125 microg/kg; in AChE of synaptossomes and TBARS levels prevented the increase in group VD125 microg/kg; in ROS levels there was not a significant difference; for the Carbonyl Content all doses prevented the increase.	ros	187-190	acetylcholinesterase	Rattus norvegicus	96-100
30187880-0	2018	[Quercetin attenuates Ox-LDL-induced calcification in vascular smooth muscle cells by regulating ROS-TLR4 signaling pathway].	ros	97-100	toll like receptor 4	Homo sapiens	101-105
30187880-10	2018	CONCLUSIONS: Quercetin inhibits Ox-LDL-induced VSMC calcification in VSMCs possibly by targeting the ROS/TLR4 signaling pathway.	ros	101-104	toll like receptor 4	Homo sapiens	105-109
31494106-7	2019	FOXP1 exhibited anti-oxidative activity in HG-induced MCs, as proved by the decreased production of ROS and expressions of ROS producing enzymes, NADPH oxidase (NOX) 2 and NOX4.	ros	100-103	forkhead box P1	Homo sapiens	0-5
31494106-7	2019	FOXP1 exhibited anti-oxidative activity in HG-induced MCs, as proved by the decreased production of ROS and expressions of ROS producing enzymes, NADPH oxidase (NOX) 2 and NOX4.	ros	123-126	forkhead box P1	Homo sapiens	0-5
31494106-9	2019	Furthermore, FOXP1 overexpression significantly prevented HG-induced activation of Akt/mTOR signaling in MCs, and Akt activator blocked FOXP1-mediated cell proliferation, ROS production and ECM accumulation in MCs.	ros	171-174	forkhead box P1	Homo sapiens	136-141
31507096-9	2019	Moreover, p120 prevented the activation of NLRP3 and regulated NLRP3 by inhibiting the TLR4 pathway and ROS production.	ros	104-107	catenin (cadherin associated protein), delta 1	Mus musculus	10-14
29601906-5	2018	Mechanistically, activated Syk repressed the expression and activity of mitochondrial complex I (COX-1), unfortunately evoking mitochondrial and/or cellular ROS overproduction.	ros	157-160	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	97-102
31507096-9	2019	Moreover, p120 prevented the activation of NLRP3 and regulated NLRP3 by inhibiting the TLR4 pathway and ROS production.	ros	104-107	NLR family, pyrin domain containing 3	Mus musculus	43-48
31507096-9	2019	Moreover, p120 prevented the activation of NLRP3 and regulated NLRP3 by inhibiting the TLR4 pathway and ROS production.	ros	104-107	NLR family, pyrin domain containing 3	Mus musculus	63-68
29721585-3	2018	Furthermore, the up-regulated LONP increased mitochondrial ROS generation to promote cell survival, cell proliferation, epithelial-mesenchymal transition, and cell migration, which was attributed to the up-regulation of NADH:ubiquinone oxidoreductase core subunit S8 via interaction with chaperone Lon under hypoxic or oxidative stress in tumorigenesis.	ros	59-62	lon peptidase 1, mitochondrial	Homo sapiens	30-34
31481238-6	2019	Activation of the HIF-1 pathway induced by NH4Cl was inhibited by addition of the antioxidant NAC or the NADPH oxidase (NOX) inhibitor apocynin, indicating the involvement of the NOX-induced ROS generation.	ros	191-194	synuclein alpha	Homo sapiens	94-97
29653689-0	2018	LPS enhances platelets aggregation via TLR4, which is related to mitochondria damage caused by intracellular ROS, but not extracellular ROS.	ros	109-112	toll like receptor 4	Homo sapiens	39-43
29410271-0	2018	Prdx1 alleviates cardiomyocyte apoptosis through ROS-activated MAPK pathway during myocardial ischemia/reperfusion injury.	ros	49-52	peroxiredoxin 1	Rattus norvegicus	0-5
29410271-8	2018	In addition, a ROS scavenger N-acetyl-l-cysteine (NAC) down-regulated the protein level of p-p38, p-JNK and Prdx1, and H9c2 cell apoptosis.	ros	15-18	mitogen-activated protein kinase 8	Rattus norvegicus	100-103
31351395-5	2019	Finally, taking into account that hypoxia-induced ROS accumulation also increases expression and activity of 5-lipoxygenase (5-LOX) with production of leukotrienes, we have disclosed structural key factors crucial for 5-LOX activity.	ros	50-53	arachidonate 5-lipoxygenase	Rattus norvegicus	109-123
29410271-8	2018	In addition, a ROS scavenger N-acetyl-l-cysteine (NAC) down-regulated the protein level of p-p38, p-JNK and Prdx1, and H9c2 cell apoptosis.	ros	15-18	peroxiredoxin 1	Rattus norvegicus	108-113
28714320-6	2018	We also provide evidence that excessive ROS triggered by polyphyllin Iota could induce G2/M phase arrest via regulating cycle proteins expression of cell cycle regulators, such as p21 and cyclinB1.	ros	40-43	H3 histone pseudogene 16	Homo sapiens	180-183
28714320-6	2018	We also provide evidence that excessive ROS triggered by polyphyllin Iota could induce G2/M phase arrest via regulating cycle proteins expression of cell cycle regulators, such as p21 and cyclinB1.	ros	40-43	cyclin B1	Homo sapiens	188-196
31351395-5	2019	Finally, taking into account that hypoxia-induced ROS accumulation also increases expression and activity of 5-lipoxygenase (5-LOX) with production of leukotrienes, we have disclosed structural key factors crucial for 5-LOX activity.	ros	50-53	arachidonate 5-lipoxygenase	Rattus norvegicus	125-130
31065944-3	2019	We discuss the agonistic effect on the Sirtuin1-PGC-1alpha-PPAR pathway as well as Sirtuin 3, which converge in improving mitochondrial function, decreasing ROS production and ameliorating bioenergetics deficits.	ros	157-160	peroxisome proliferator activated receptor alpha	Homo sapiens	59-63
31096129-5	2019	Furthermore, ZnO particles exposure resulted in a significant decrease in UCH-L1 expression in SH-SY5Y; whereas UCH-L1 overexpression led to a significant increase in cell viability and a sharp decrease in ROS level.	ros	206-209	ubiquitin C-terminal hydrolase L1	Homo sapiens	112-118
29799157-10	2018	These findings indicate that ALDH2 deficiency aggravated CCl4 -induced hepatic fibrosis through ROS overproduction, increased apoptosis and mitochondrial damage, whereas ALDH2 activation through Alda-1 administration alleviated hepatic fibrosis partly through activation of the Nrf2/HO-1 antioxidant pathway and Parkin-related mitophagy, which indicate ALDH2 as a promising anti-fibrotic target and Alda-1 as a potential therapeutic agent in treating CCl4 -induced liver fibrosis.	ros	96-99	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	29-34
31599445-5	2019	Cardiolipin is reported to be effective to trigger the activation of NLRP3 inflammasome through a ROS-independent signaling pathway.	ros	98-101	NLR family, pyrin domain containing 3	Mus musculus	69-74
29795387-7	2018	Results showed that OGG1-BER further increases the levels of ROS-induced DNA damage by generating repair intermediates, leading to PARP1 overactivation and cell death.	ros	61-64	8-oxoguanine DNA glycosylase	Homo sapiens	20-24
29795387-8	2018	Cells lacking or expressing repair-deficient OGG1 showed lower levels of DNA strand lesions, PARP1 activation, and nuclear translocation of apoptosis-inducing factor, resulting in the increased resistance to ROS-induced parthanatos.	ros	208-211	8-oxoguanine DNA glycosylase	Homo sapiens	45-49
31271840-4	2019	Moreover, significantly higher intracellular ROS levels were detected in mIgM+ B lymphocytes following rIL-10 stimulation.	ros	45-48	interleukin 10	Rattus norvegicus	103-109
29725369-9	2018	EP upregulated CYP2E1, downregulated PPAR-alpha, nuclear factor 2 (Nrf2) and very-low density lipoprotein receptor (VLDLR), positively regulated the CYP2E1-PPAR-alpha-ROS signaling pathway and negatively regulated the ROS-Nrf2-VLDLR signaling pathway.	ros	167-170	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	149-155
29725369-9	2018	EP upregulated CYP2E1, downregulated PPAR-alpha, nuclear factor 2 (Nrf2) and very-low density lipoprotein receptor (VLDLR), positively regulated the CYP2E1-PPAR-alpha-ROS signaling pathway and negatively regulated the ROS-Nrf2-VLDLR signaling pathway.	ros	218-221	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	149-155
31271840-6	2019	In addition, we also found that the enhancing effect of IL-10 on phagocytosis and intracellular ROS levels of mIgM+ B lymphocytes were suppressed by the administration of niclosamide.	ros	96-99	interleukin 10	Rattus norvegicus	56-61
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	X-box binding protein 1	Homo sapiens	291-315
31158443-5	2019	We also found that active cysteine residues provide a structural and functional link between these two distinct functions of Prx1 (i.e., ROS scavenging and RNA-binding activities).	ros	137-140	peroxiredoxin 1	Homo sapiens	125-129
31310795-9	2019	It elucidated the underlying epigenetic regulatory mechanism, whereby cyclophosphamide-dependent microRNA-15b inhibited Kl expression, leading to the reduced ability of mOGCs to induce autophagy and ROS scavenging, ultimately causing POF.	ros	199-202	microRNA 15b	Mus musculus	97-109
29605530-0	2018	Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser727.	ros	76-79	signal transducer and activator of transcription 3	Rattus norvegicus	125-130
29605530-12	2018	The preservation of ND6 mtDNA and the inhibition of SDH activity may account for the role of STAT3 in the beneficial action of zinc on the mitochondrial oxidative phosphorylation and ROS generation at reperfusion.	ros	183-186	signal transducer and activator of transcription 3	Rattus norvegicus	93-98
29565448-3	2018	Our previous study revealed that kaempferol triggered apoptosis in human umbilical vein endothelial cells (HUVECs) by ROS-mediated p53/ATM/death receptor signaling.	ros	118-121	ATM serine/threonine kinase	Homo sapiens	135-138
31069623-10	2019	In conclusion, FTY720 may reduce PD progression by inhibiting NLRP3 inflammasome activation via its effects on ROS generation and p65 activation in microglia.	ros	111-114	NLR family, pyrin domain containing 3	Mus musculus	62-67
29565452-8	2018	Furthermore, pretreatment of Caki cells with ROS scavengers (N-acetylcysteine and glutathione) prevented the downregulation of cFLIP(L), the upregulation of cFLIP(S) and apoptosis induced by FasL.	ros	45-48	Fas ligand	Homo sapiens	191-195
29565452-9	2018	Collectively, these data indicated that a novel pathway of cFLIP(L)/(S) differential expression pattern was associated with FasL-induced apoptosis and modulated by ROS generation.	ros	164-167	Fas ligand	Homo sapiens	124-128
21169401-10	2011	Therefore, cyclic uniaxial stretch activates Notch3 signaling through a ROS-mediated mechanism, and the presence of Notch3 is necessary for proper stretch-induced cell alignment in VSMCs.	ros	72-75	notch receptor 3	Homo sapiens	45-51
30710171-7	2019	The results of western blotting (WB) assay shown in 1"s phototoxicity could induce cell apoptosis via ROS-mediated mitochondrial caspase apoptosis pathway, in which SIRT1 protein degradation played a key role.	ros	102-105	sirtuin 1	Mus musculus	165-170
21335461-3	2011	We hypothesized that overexpression of an antioxidant network (AON) composed of SOD1, SOD3, and glutathione peroxidase (GSHPx)-1 would reduce myocardial ischemia-reperfusion injury by limiting ROS-mediated lipid peroxidation and oxidative posttranslational modification (OPTM) of proteins.	ros	193-196	glutathione peroxidase 1	Mus musculus	120-128
21335461-6	2011	These data demonstrate that concomitant SOD1, SOD3, and GSHPX-1 expression confers marked protection against myocardial ischemia-reperfusion injury, reducing ROS, ROS-mediated lipid peroxidation, and OPTM of critical cardiac proteins, including cardiac fatty acid-binding protein and SERCA2a.	ros	158-161	superoxide dismutase 3, extracellular	Mus musculus	46-50
21335461-6	2011	These data demonstrate that concomitant SOD1, SOD3, and GSHPX-1 expression confers marked protection against myocardial ischemia-reperfusion injury, reducing ROS, ROS-mediated lipid peroxidation, and OPTM of critical cardiac proteins, including cardiac fatty acid-binding protein and SERCA2a.	ros	158-161	glutathione peroxidase 1	Mus musculus	56-63
21335461-6	2011	These data demonstrate that concomitant SOD1, SOD3, and GSHPX-1 expression confers marked protection against myocardial ischemia-reperfusion injury, reducing ROS, ROS-mediated lipid peroxidation, and OPTM of critical cardiac proteins, including cardiac fatty acid-binding protein and SERCA2a.	ros	163-166	superoxide dismutase 3, extracellular	Mus musculus	46-50
21335461-6	2011	These data demonstrate that concomitant SOD1, SOD3, and GSHPX-1 expression confers marked protection against myocardial ischemia-reperfusion injury, reducing ROS, ROS-mediated lipid peroxidation, and OPTM of critical cardiac proteins, including cardiac fatty acid-binding protein and SERCA2a.	ros	163-166	glutathione peroxidase 1	Mus musculus	56-63
21479273-7	2011	Moreover, PKG stimulation of Kir6.2/SUR2A channels in intact cells was abrogated by ROS/H(2)O(2) scavenging, antagonism of calmodulin, and blockade of calcium/calmodulin-dependent protein kinase II (CaMKII), respectively.	ros	84-87	protein kinase cGMP-dependent 1	Homo sapiens	10-13
21479273-9	2011	PKG stimulation of K(ATP) channels was confirmed in intact ventricular cardiomyocytes, which was ROS- and CaMKII-dependent.	ros	97-100	protein kinase cGMP-dependent 1	Homo sapiens	0-3
29669933-8	2018	ROS activated Etv2 expression in ECs, and ROS blockade inhibited Etv2 expression in TAECs in vivo.	ros	0-3	ets variant 2	Mus musculus	14-18
29669933-8	2018	ROS activated Etv2 expression in ECs, and ROS blockade inhibited Etv2 expression in TAECs in vivo.	ros	42-45	ets variant 2	Mus musculus	65-69
29669943-7	2018	Finally, we demonstrated that the loss of DHTKD1 expression increased ROS production and induced the expression of viperin, a gene previously shown to be involved in production of Th2 cytokines in T cells.	ros	70-73	dehydrogenase E1 and transketolase domain containing 1	Homo sapiens	42-48
21479273-11	2011	CONCLUSION: The present study provides novel evidence that PKG exerts dual regulation of cardiac K(ATP) channels, including marked stimulation resulting from intracellular signaling mediated by ROS (H(2)O(2) in particular), calmodulin and CaMKII, alongside of moderate channel suppression likely mediated by direct PKG phosphorylation of the channel or some closely associated proteins.	ros	194-197	protein kinase cGMP-dependent 1	Homo sapiens	59-62
31455158-2	2019	When deregulated, MYC drives genomic instability via several mechanisms including aberrant proliferation, replication stress and ROS production.	ros	129-132	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-21
21479273-12	2011	The novel cGMP/PKG/ROS/calmodulin/CaMKII signaling pathway may regulate cardiomyocyte excitability by opening K(ATP) channels and contribute to cardiac protection against ischemia-reperfusion injury.	ros	19-22	protein kinase cGMP-dependent 1	Homo sapiens	15-18
20980255-7	2011	Furthermore, mTORC2 down-regulation decreased PGE(2)-induced production of the chemokine monocyte chemoattractant protein-1 (CCL2), which was linked to a significant reduction in ROS production.	ros	179-182	C-C motif chemokine ligand 2	Homo sapiens	125-129
31427566-0	2019	Regulating autophagy facilitated therapeutic efficacy of the sonic Hedgehog pathway inhibition on lung adenocarcinoma through GLI2 suppression and ROS production.	ros	147-150	sonic hedgehog signaling molecule	Homo sapiens	61-75
21253614-13	2011	CONCLUSIONS/SIGNIFICANCE: We present evidence that NADPH oxidase derived ROS plays a role in the direct Treg mediated suppression of CD4+ effector T cells in a process that is blocked by thiol-containing antioxidants, NADPH oxidase inhibitors or a lack of Ncf1 expression in Tregs and Teffs.	ros	73-76	neutrophil cytosolic factor 1	Mus musculus	256-260
31266772-6	2019	Reduced expression of HIF2alpha inhibited the self-renewal of Sca-1+ cells; this effect was blocked through suppression of ROS by N-acetyl cysteine or the knockdown of p53, Nanog, or Sox2.	ros	123-126	endothelial PAS domain protein 1	Homo sapiens	22-31
21123948-5	2011	Knockdown of TXNL2 in human breast cancer cell lines increased ROS levels and reduced NF-kappaB activity, resulting in inhibition of in vitro proliferation, survival, and invasion.	ros	63-66	glutaredoxin 3	Homo sapiens	13-18
22046279-9	2011	In primary macrophages isolated form C57/BL6 male mice, we identify mitochondrial ROS formation by CO as the upstream trigger for the observed effects on Egr-1 in part through uncoupling protein 2 (UCP2).	ros	82-85	early growth response 1	Mus musculus	154-159
21904662-9	2011	Measurement of oxidized lipids in urine from humans with BMPR2 mutations demonstrated increased ROS, regardless of disease status.	ros	96-99	bone morphogenetic protein receptor type 2	Homo sapiens	57-62
31380641-4	2019	The expression levels of SODs, PODs, P5CSs, and AtMYB61 were inhibited by ZmNAC071, which results in reduced ROS scavenging and proline content, increased ROS level, and water loss.	ros	109-112	myb domain protein 61	Arabidopsis thaliana	48-55
21106063-9	2010	A likely consequence of loss of GPX3 protein function would be a higher amount of ROS in the cancer cell environment.	ros	82-85	glutathione peroxidase 3	Rattus norvegicus	32-36
31074003-0	2019	Early toll-like receptor 4 blockade reduces ROS and inflammation triggered by microglial pro-inflammatory phenotype in rodent and human brain ischaemia models.	ros	44-47	toll like receptor 4	Homo sapiens	6-26
20332002-5	2010	In mitochondria, p13 produces an inward K+current that results in an increased production of ROS by mitochondria.	ros	93-96	H3 histone pseudogene 6	Homo sapiens	17-20
31093964-2	2019	Histidine-rich glycoprotein (HRG) is a 75-kDa plasma protein that was demonstrated to improve the survival of septic mice through regulation of cell shape, spontaneous ROS production in neutrophils, and adhesion of neutrophils to vascular endothelial cells.	ros	168-171	histidine-rich glycoprotein	Mus musculus	0-27
20890104-3	2010	Our research into mechanisms of TSC2 regulation helped uncover a pathway upstream of TSC2 that is regulated by cytoplasmic ATM in response to ROS initiated by ATM activation of LKB1 and AMPK.	ros	142-145	ATM serine/threonine kinase	Homo sapiens	123-126
20890104-3	2010	Our research into mechanisms of TSC2 regulation helped uncover a pathway upstream of TSC2 that is regulated by cytoplasmic ATM in response to ROS initiated by ATM activation of LKB1 and AMPK.	ros	142-145	ATM serine/threonine kinase	Homo sapiens	159-162
20890104-3	2010	Our research into mechanisms of TSC2 regulation helped uncover a pathway upstream of TSC2 that is regulated by cytoplasmic ATM in response to ROS initiated by ATM activation of LKB1 and AMPK.	ros	142-145	serine/threonine kinase 11	Homo sapiens	177-181
31093964-2	2019	Histidine-rich glycoprotein (HRG) is a 75-kDa plasma protein that was demonstrated to improve the survival of septic mice through regulation of cell shape, spontaneous ROS production in neutrophils, and adhesion of neutrophils to vascular endothelial cells.	ros	168-171	histidine-rich glycoprotein	Mus musculus	29-32
31085189-6	2019	Further studies illustrated that GRSF1 regulated myogenic differentiation through direct targeting of mitochondrial GPX4, a key regulator of the cellular redox status, leading to the modulation of ROS levels, which is important for myogenesis.	ros	197-200	glutathione peroxidase 4	Mus musculus	116-120
20830294-9	2010	Pre-exposure of hepatocytes to a JNK inhibitor SP600125 prevented As-induced caspase-3 activation, ROS production and loss in cell viability.	ros	99-102	mitogen-activated protein kinase 8	Rattus norvegicus	33-36
21132068-4	2010	In contrast, the addition of HMG sensitizes LNCaP or PC3 prostate cancer cells harboring an active Akt to apoptosis, in which ROS is upregulated to induce the UPR and GADD153 expression.	ros	126-129	chromobox 8	Homo sapiens	53-56
31153046-11	2019	The results of this study suggested a protective role of CORM-2 in PM-induced lung inflammation by inhibiting the TLR2 and TLR4/ROS-NLRP3 inflammasome-CRP axial.	ros	128-131	NLR family, pyrin domain containing 3	Mus musculus	132-137
31085231-6	2019	Bleomycin treatment resulted in decreases in protein expressions of Sirtuin 3 (SIRT3) in the lung, which were restored by ROS scavenger NAC and probucol treatment, suggesting that probucol might restore SIRT3 expression by suppressing bleomycin-induced oxidative stress.	ros	122-125	sirtuin 3	Mus musculus	68-77
20644252-10	2010	Sirt3 inactivation increased mitochondrial ROS production, leading to p53 upregulation and changes in downstream gene expression.	ros	43-46	sirtuin 3	Mus musculus	0-5
20644252-10	2010	Sirt3 inactivation increased mitochondrial ROS production, leading to p53 upregulation and changes in downstream gene expression.	ros	43-46	transformation related protein 53, pseudogene	Mus musculus	70-73
20644252-11	2010	The inactivation of p53 improved the developmental outcome of Sirt3-knockdown embryos, indicating that the ROS-p53 pathway was responsible for the developmental defects.	ros	107-110	transformation related protein 53, pseudogene	Mus musculus	20-23
20644252-11	2010	The inactivation of p53 improved the developmental outcome of Sirt3-knockdown embryos, indicating that the ROS-p53 pathway was responsible for the developmental defects.	ros	107-110	sirtuin 3	Mus musculus	62-67
31085231-6	2019	Bleomycin treatment resulted in decreases in protein expressions of Sirtuin 3 (SIRT3) in the lung, which were restored by ROS scavenger NAC and probucol treatment, suggesting that probucol might restore SIRT3 expression by suppressing bleomycin-induced oxidative stress.	ros	122-125	sirtuin 3	Mus musculus	79-84
20644252-11	2010	The inactivation of p53 improved the developmental outcome of Sirt3-knockdown embryos, indicating that the ROS-p53 pathway was responsible for the developmental defects.	ros	107-110	transformation related protein 53, pseudogene	Mus musculus	111-114
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	ros	64-67	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	9-12
20430109-0	2010	Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells.	ros	67-70	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	80-84
31171361-1	2019	The transformation of hepatic stellate cells (HSCs) to activated myofibroblasts plays a critical role in the progression of hepatic fibrosis, while iron-catalyzed production of free radical, including reaction and active oxygen (ROS), and activation and transformation of HSC into a myofibroblasts has been regarded as a major mechanism.	ros	229-232	fucosyltransferase 1 (H blood group)	Homo sapiens	46-49
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	276-279	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-25
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	276-279	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-107
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	364-367	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-25
20649551-3	2010	We demonstrated that excess ROS produced by defective mitochondria could increase the acetylation of microtubule proteins through the suppression of Sirt2, which results in perinuclear distribution of mitochondria in skin fibroblasts of patients with CPEO syndrome.	ros	28-31	sirtuin 2	Homo sapiens	149-154
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	364-367	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-107
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	ros	116-119	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	60-63
31413744-4	2019	Moreover, we have found that ALDH1A3 protein is a key inactivator of ROS-generated aldehydes, which is a perspective target for the development of new chemotherapeutic drugs.	ros	69-72	aldehyde dehydrogenase 1 family member A3	Homo sapiens	29-36
20165904-4	2010	In addition, NYGGF4 overexpression also led to an imbalance of the mitochondrial dynamics and excess intracellular ROS production.	ros	115-118	phosphotyrosine interaction domain containing 1	Homo sapiens	13-19
20347035-6	2010	NOX1 was determined to be crucial for enhanced ROS production in intermittent hypoxia that in turn mediated induction of Nrf2 and Trx1.	ros	47-50	thioredoxin	Homo sapiens	130-134
31222103-7	2019	We show that activation of the oncogene ErbB2 is associated with increased ROS and that high ROS sub-population of ErbB2 cancer cells show elevated SOD1.	ros	75-78	erb-b2 receptor tyrosine kinase 2	Mus musculus	40-45
20145198-6	2010	Moreover, the addition of NAC, a scavenger of ROS, abrogated the rVpr-induced formation of OxPC, the phosphorylation of C/EBP-beta, a substrate of MAPK, and IL-6 production.	ros	46-49	synuclein alpha	Homo sapiens	26-29
31222103-7	2019	We show that activation of the oncogene ErbB2 is associated with increased ROS and that high ROS sub-population of ErbB2 cancer cells show elevated SOD1.	ros	93-96	erb-b2 receptor tyrosine kinase 2	Mus musculus	40-45
31222103-7	2019	We show that activation of the oncogene ErbB2 is associated with increased ROS and that high ROS sub-population of ErbB2 cancer cells show elevated SOD1.	ros	93-96	erb-b2 receptor tyrosine kinase 2	Mus musculus	115-120
31209224-11	2019	These data suggest modulation of GsdmD/caspase-8 may be a novel therapeutic option in ROS-mediated liver injury.	ros	86-89	caspase 8	Mus musculus	39-48
20032314-8	2010	Inhibition of G6PD with siRNA led to increased ROS and apoptosis, decreased proliferation, and impaired insulin secretion.	ros	47-50	glucose-6-phosphate dehydrogenase 2	Mus musculus	14-18
31160554-1	2019	Peroxiredoxin II (Prx II), an antioxidant enzyme in the Prx family, reduces oxidative stress by decreasing the intracellular ROS levels.	ros	125-128	periaxin	Mus musculus	18-21
31360100-7	2019	Moreover, silencing of the caffeine-antagonized adenosine A2a receptor (A2aR) significantly decreased cleaved caspase 1 expression in THP-1 macrophages by reducing ROS production.	ros	164-167	adenosine A2a receptor	Homo sapiens	48-70
20339118-11	2010	Nox5 activation by Ang II and ET-1 induces ROS generation and ERK1/2 phosphorylation.	ros	43-46	NADPH oxidase 5	Homo sapiens	0-4
29692895-11	2018	Overexpression of mutant IDH1 in a wildtype line did not reproduce the range of metabolic differences observed in lines expressing endogenous mutations, but resulted in depletion of glutamine and TCA cycle intermediates, an increase in DNA damage following radiation, and a rise in intracellular ROS.	ros	296-299	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	25-29
31360100-7	2019	Moreover, silencing of the caffeine-antagonized adenosine A2a receptor (A2aR) significantly decreased cleaved caspase 1 expression in THP-1 macrophages by reducing ROS production.	ros	164-167	adenosine A2a receptor	Homo sapiens	72-76
31360100-8	2019	Given these findings, we conclude that caffeine inhibits NLRP3 inflammasome activation by suppressing MAPK/NF-kappaB signaling and A2aR-associated ROS production in LPS-induced THP-1 macrophages.	ros	147-150	adenosine A2a receptor	Homo sapiens	131-135
20392947-11	2010	This is the first work to demonstrate the essential role of p66(shc) in mediating requisite mitochondrial and energetic compensation after preconditioning and suggests a mechanism by which protein and organelle damage mediated by ROS can increase HSP70.	ros	230-233	DNA polymerase delta 3, accessory subunit	Homo sapiens	60-63
30767087-0	2019	Autophagy inhibition with chloroquine reverts paclitaxel resistance and attenuates metastatic potential in human nonsmall lung adenocarcinoma A549 cells via ROS mediated modulation of beta-catenin pathway.	ros	157-160	catenin beta 1	Homo sapiens	184-196
30981108-3	2019	Our data demonstrated that IL-24 application promoted cancer death by inducing mitochondrial stress, as manifested by mitochondrial ROS overproduction, mitochondrial potential dissipation, cellular ATP deprivation and mitochondrial death activation.	ros	132-135	interleukin 24	Homo sapiens	27-32
19754673-2	2010	These radicals are important part of groups of molecules called reactive oxygen/nitrogen species (ROS/RNS), which are produced during cellular metabolism and functional activities and have important roles in cell signalling, apoptosis, gene expression and ion transportation.	ros	98-101	FAM20C golgi associated secretory pathway kinase	Homo sapiens	102-105
29849892-8	2018	Notably, 15 min ST significantly increased sirtuin (SIRT) 3 level (2.7-fold) in vivo while the inhibition of SIRT3 exacerbated senescent H9c2 cellular LDH release and ROS production under hypoxia.	ros	167-170	sirtuin 3	Mus musculus	109-114
31042074-0	2019	Hydrogen-rich saline ameliorated LPS-induced acute lung injury via autophagy inhibition through the ROS/AMPK/mTOR pathway in mice.	ros	100-103	mechanistic target of rapamycin kinase	Mus musculus	109-113
29360568-11	2018	Pharmacological or genetic inhibition of DRP1 enhanced palmitate-induced mitochondrial ROS production, c-Jun phosphorylation, and inflammatory cytokine expression.	ros	87-90	dynamin 1 like	Homo sapiens	41-45
28480509-7	2018	KEY RESULTS: Ox-LDL, but not LDL, significantly increased ENaC activity in the endothelial cells attached to split-open thoracic aortas, and the increase was inhibited by a lectin-like ox-LDL receptor-1 (LOX-1) antagonist (kappa-carrageenan), an NADPH oxidase inhibitor (apocynin), and a scavenger of ROS (TEMPOL).	ros	301-304	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	173-202
28480509-10	2018	CONCLUSION AND IMPLICATIONS: Ox-LDL stimulates ENaC in endothelial cells through LOX-1 receptor-mediated activation of NADPH oxidase and accumulation of intracellular ROS.	ros	167-170	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	81-86
29421327-7	2018	Intracellular ROS accumulation arouses ER stress, initiating PERK dependent UPR and inducing the downstream signal Nrf2 and ATF4 auto-phosphorylation.	ros	14-17	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	61-65
29397791-4	2018	Glutaredoxin 3 (GLRX3), also known as TXNL2, Grx3 and PICOT, maintains a low level of ROS, thus contributing to the survival and metastasis of several types of cancer.	ros	86-89	glutaredoxin 3	Homo sapiens	0-14
29397791-4	2018	Glutaredoxin 3 (GLRX3), also known as TXNL2, Grx3 and PICOT, maintains a low level of ROS, thus contributing to the survival and metastasis of several types of cancer.	ros	86-89	glutaredoxin 3	Homo sapiens	16-21
29397791-4	2018	Glutaredoxin 3 (GLRX3), also known as TXNL2, Grx3 and PICOT, maintains a low level of ROS, thus contributing to the survival and metastasis of several types of cancer.	ros	86-89	glutaredoxin 3	Homo sapiens	38-43
29397791-4	2018	Glutaredoxin 3 (GLRX3), also known as TXNL2, Grx3 and PICOT, maintains a low level of ROS, thus contributing to the survival and metastasis of several types of cancer.	ros	86-89	glutaredoxin 3	Homo sapiens	45-49
29397791-4	2018	Glutaredoxin 3 (GLRX3), also known as TXNL2, Grx3 and PICOT, maintains a low level of ROS, thus contributing to the survival and metastasis of several types of cancer.	ros	86-89	glutaredoxin 3	Homo sapiens	54-59
29397791-8	2018	Importantly, knockdown of GLRX3 triggered the generation of ROS.	ros	60-63	glutaredoxin 3	Homo sapiens	26-31
29397791-9	2018	Furthermore, N-acetyl cysteine (NAC), an ROS scavenger, enhanced the effects of GLRX3 knockdown on Notch-dependent EMT.	ros	41-44	glutaredoxin 3	Homo sapiens	80-85
29397791-10	2018	Collectively, these findings suggested the vital roles of GLRX3 in OSCC progression through its relationship with EMT progression, and these data also suggest that a strategy of blocking ROS to enhance the activity of GLRX3 knockdown warrants further attention in the treatment of OSCC.	ros	187-190	glutaredoxin 3	Homo sapiens	218-223
29414102-6	2018	We demonstrated that overexpression of wild type alpha-synuclein causes moderated toxicity, ROS generation and mitochondrial dysfunction.	ros	92-95	synuclein alpha	Homo sapiens	49-64
29356020-7	2018	RESULTS: Matrine promoted the expression of GADD45B, a tumor suppressive gene that is involved in the regulation of cell cycle, DNA damage repair, cell survival, aging, apoptosis and other cellular processes through p38/JNK, ROS-GADD45B-p38, or other signal pathways.	ros	225-228	growth arrest and DNA damage inducible beta	Homo sapiens	44-51
29655679-10	2018	In parallel, the formation of ROS induced by VEGF in cultured endothelial cells was markedly reduced in the present of PCRR extract.	ros	30-33	vascular endothelial growth factor Aa	Danio rerio	45-49
29511199-0	2018	Author Correction: PLK2 Plays an Essential Role in High D-Glucose-Induced Apoptosis, ROS Generation and Inflammation in Podocytes.	ros	85-88	polo like kinase 2	Homo sapiens	19-23
29264745-4	2018	We report that TLR4 activation by lipopolysaccharide repressed white adipocyte browning in response to beta3-adrenergic receptor activation and caused ROS production and mitochondrial dysfunction, while genetic deletion of TLR4 protected mitochondrial function and thermogenesis.	ros	151-154	toll like receptor 4	Homo sapiens	15-19
29363860-0	2018	ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway.	ros	102-105	microRNA 18a	Homo sapiens	89-96
20351780-3	2010	Selective loss or blockade of cytosolic Hsp60 by specific antisense oligonucleotide or neutralizing antibody diminished the IKK/NF-kappaB activation and the expression of NF-kappaB target genes, such as Bfl-1/A1 and MnSOD, which thus augmented intracellular ROS production and ASK1-dependent cell death, in response to TNF-alpha.	ros	258-261	heat shock protein 1 (chaperonin)	Mus musculus	40-45
19698762-6	2010	Bad and Bim are pro-apoptotic proteins that cause mitochondrial dysfunction characterized by excessive ROS formation, mitochnondrial DNA (mtDNA) damage, and release of mitochondrial apoptotic proteins including cytochrome c, apoptosis inducing factor (AIF), endonuclease G and Smac.	ros	103-106	BCL2 like 11	Homo sapiens	8-11
19944085-6	2010	4-HEB caused significant intracellular GSH depletion, ROS formation, and showed significantly less toxicity to tyrosinase specific shRNA transfected SK-MEL-28 cells.	ros	54-57	transcription factor 12	Homo sapiens	2-5
20036412-5	2010	Moreover, the transcriptional expression of mitochondrial inner membrane genes related to ROS production, such as Ucp-2 and Bcl-2, were altered significantly in high ATZ treatment groups.	ros	90-93	uncoupling protein 2	Danio rerio	114-119
19820034-7	2009	eNOS uncoupling was observed in lung tissues of adult, but not newborn, heterozygous mice and was associated with increased production of reactive O(2) species (ROS) in adult Eng(+/-) vs. control lungs.	ros	161-164	endoglin	Mus musculus	175-178
19687137-5	2009	Here we show that the three adPEO-associated mutations equivalent to A114P, L98P, and V289M introduced into the Podospora anserina ANT1 ortholog dominantly cause severe growth defects, decreased reactive oxygen species production (ROS), decreased mitochondrial inner membrane potential (Deltapsi), and accumulation of large-scale mtDNA deletions leading to premature death.	ros	231-234	solute carrier family 25 member 4	Homo sapiens	131-135
19482076-8	2009	All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation.	ros	89-92	heat shock protein 90 alpha family class A member 1	Homo sapiens	220-225
19482076-8	2009	All these results collectively suggest that 4-HPR-induced apoptosis is associated with a ROS-mediated conformational change in Akt, and this change, as a consequence, mediates dephosphorylation of Akt via regulating Akt-Hsp90 or Akt-PP2A complex formation.	ros	89-92	protein phosphatase 2 phosphatase activator	Homo sapiens	233-237
19118560-5	2009	MitoK(ATP) opening causes an increase in ROS production, which activates mitochondrial protein kinase C epsilon (PKCvarepsilon), which inhibits the mitochondrial permeability transition (MPT), thus decreasing cell death.	ros	41-44	protein kinase C epsilon	Homo sapiens	87-111
19366706-7	2009	Hyperoxia caused rapid activation and redistribution of Rac1, and IQGAP1 to cell periphery, and down-regulation of Rac1, and IQGAP1 attenuated hyperoxia-induced tyrosine phosphorylation of Src and cortactin and ROS generation.	ros	211-214	IQ motif containing GTPase activating protein 1	Homo sapiens	125-131
19366706-10	2009	These results demonstrate a role of PLD in hyperoxia-mediated IQGAP1 activation through Rac1 in tyrosine phosphorylation of Src and cortactin, as well as in p47(phox) translocation and ROS formation in human lung endothelial cells.	ros	185-188	IQ motif containing GTPase activating protein 1	Homo sapiens	62-68
19337996-8	2009	Therefore, our results suggest that autocrine IFN-gamma can negatively regulate the neo-generation of FOXP3(+) iTreg through ROS-mediated apoptosis in the periphery.	ros	125-128	forkhead box P3	Mus musculus	102-107
19150880-16	2009	CONCLUSIONS: These in vivo and in vitro data support that Trx2 maintains EC function by two parallel pathways-scavenging ROS to increase NO bioavailability and inhibiting ASK1 activity to enhance EC survival, facilitating ischemia-mediated arteriogenesis and angiogenesis.	ros	121-124	thioredoxin 2	Mus musculus	58-62
18775488-2	2008	Here, we report evidence that treatment with globular adiponectin (gAd) induces apoptosis in murine macrophage-like RAW264 cells through the generation of reactive oxygen and/or nitrogen species (ROS/RNS).	ros	196-199	adiponectin, C1Q and collagen domain containing	Mus musculus	54-65
18775488-6	2008	In addition, transfection with p47(phox)- or gp91(phox)-specific small interfering RNA (siRNA) partially reduced ROS and apoptosis in response to gAd treatment.	ros	113-116	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	31-34
18775488-6	2008	In addition, transfection with p47(phox)- or gp91(phox)-specific small interfering RNA (siRNA) partially reduced ROS and apoptosis in response to gAd treatment.	ros	113-116	paired Ig-like receptor B	Mus musculus	45-49
18830414-6	2008	In addition, T-ALL cells had constitutively high levels of ROS, which can also downmodulate PTEN activity.	ros	59-62	phosphatase and tensin homolog	Homo sapiens	92-96
18830414-7	2008	Accordingly, both CK2 inhibitors and ROS scavengers restored PTEN activity and impaired PI3K/Akt signaling in T-ALL cells.	ros	37-40	phosphatase and tensin homolog	Homo sapiens	61-65
18487368-6	2008	The effect of p53 deficiency on basal reactive oxygen species levels (ROS) within the RGC and on susceptibility to oxidative-signaling-induced apoptosis was measured by flow cytometry.	ros	70-73	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	14-17
18487368-10	2008	p53 knockdown resulted in a corresponding increase in basal cellular ROS levels and increased susceptibility to oxidative-signaling-induced cell death.	ros	69-72	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	0-3
18634846-6	2008	Pretreatment with EPO prior to Abeta(25-35) exposure significantly elevated cell viability, reduced Abeta(25-35)-induced apoptosis, decreased ROS production, and stabilized mitochondrial membrane potential.	ros	142-145	erythropoietin	Rattus norvegicus	18-21
18634846-7	2008	Furthermore, EPO also attenuated the downstream cascade following ROS, including Bcl-2/Bax, and caspase-3 activation.	ros	66-69	erythropoietin	Rattus norvegicus	13-16
19086304-6	2008	RESULTS: The depletion of Prx III resulted in increased intracellular ROS levels accompanied by enhanced apoptosis by ototoxic drugs.	ros	70-73	peroxiredoxin 3	Mus musculus	26-33
18593583-5	2008	These results suggest that regulation of the anti-oxidant enzyme HO-1 via the PI3K and p38/Nrf2 signaling pathways controls the intracellular levels of ROS.	ros	152-155	heme oxygenase 1	Homo sapiens	65-69
18549279-7	2008	The expression level of TrxR was negatively correlated with ROS accumulation, DNA damage and apoptosis, implicating TrxR in FK228-induced apoptosis and HDACi sensitivity in cancer cells.	ros	60-63	peroxiredoxin 5	Homo sapiens	24-28
31083670-5	2019	RESULTS: Knockdown of PTOV1 and PIN1 inhibited the cell proliferation, colony formation, migration, cell cycle, and induced nuclear condensation as well as ROS production.	ros	156-159	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	32-36
30735837-0	2019	Sirt3 mediates the protective effect of hydrogen in inhibiting ROS-induced retinal senescence.	ros	63-66	sirtuin 3	Mus musculus	0-5
20731933-4	2008	METHODS: We confirmed that MSA and selenite have the anticancer effect in the human high-metastatic large cell lung cancer cell line L9981 by growth inhibition detection, we detect the ROS induced by MSA and selenite in L9981 by fluorescence microscopy, and use flow cytometry to quantitate the ROS induced by NAC together with selenium compounds.	ros	185-188	synuclein alpha	Homo sapiens	310-313
18348865-5	2008	Thus, the choice between modification of PLZF by SUMO or ubiquitin was determined by the intracellular level of ROS, which was generated by serum deprivation that inactivated the SUMO-conjugating enzymes Uba2 and Ubc9, and resulted in decrease of sumoylation.	ros	112-115	ubiquitin like modifier activating enzyme 2	Homo sapiens	204-208
30901738-9	2019	By employing SRT1720 and sirtinol, the activator and inhibitor of sirtuin 1 (SIRT1), we found that SRT1720 partially eliminated the increase in ROS,and sirtinol further promoted the increase in ROS caused by NMDA.	ros	144-147	sirtuin 1	Mus musculus	66-75
18234413-12	2008	Our study reveals that important differences exist between flavonoids with different structural features in their capacity to abrogate the generation of different ROS/RNS, and suggests that the modulation of antioxidant enzymes by flavonoids may be also important in their antioxidant effects in liver cells.	ros	163-166	FAM20C golgi associated secretory pathway kinase	Homo sapiens	167-170
18202147-0	2008	Regulation of parathyroid hormone type 1 receptor dynamics, traffic, and signaling by the Na+/H+ exchanger regulatory factor-1 in rat osteosarcoma ROS 17/2.8 cells.	ros	147-150	SLC9A3 regulator 1	Rattus norvegicus	90-126
30901738-9	2019	By employing SRT1720 and sirtinol, the activator and inhibitor of sirtuin 1 (SIRT1), we found that SRT1720 partially eliminated the increase in ROS,and sirtinol further promoted the increase in ROS caused by NMDA.	ros	144-147	sirtuin 1	Mus musculus	77-82
18202147-1	2008	The effects of the expression of the Na+/H+ exchanger regulatory factor-1 (NHERF1) on the distribution, dynamics, and signaling properties of the PTH type 1 receptor (PTH1R) were studied in rat osteosarcoma cells ROS 17/2.8.	ros	213-216	SLC9A3 regulator 1	Rattus norvegicus	75-81
18202147-8	2008	Based on these analyses, we propose that, in ROS cells, the presence of NHERF1 induces PTH-dependent calcium signaling by a cAMP-mediated mechanism that involves local protein kinase A-dependent activation of calcium channels.	ros	45-48	SLC9A3 regulator 1	Rattus norvegicus	72-78
30901738-9	2019	By employing SRT1720 and sirtinol, the activator and inhibitor of sirtuin 1 (SIRT1), we found that SRT1720 partially eliminated the increase in ROS,and sirtinol further promoted the increase in ROS caused by NMDA.	ros	194-197	sirtuin 1	Mus musculus	66-75
30901738-9	2019	By employing SRT1720 and sirtinol, the activator and inhibitor of sirtuin 1 (SIRT1), we found that SRT1720 partially eliminated the increase in ROS,and sirtinol further promoted the increase in ROS caused by NMDA.	ros	194-197	sirtuin 1	Mus musculus	77-82
17979497-6	2008	Reactive oxygen and nitrogen species (ROS/RNS) have been shown to mediate the induction of PAI-1 by many of these stimuli.	ros	38-41	serpin family E member 1	Homo sapiens	91-96
30909091-5	2019	We demonstrated that knockdown of LMP1 and 2A blocks the translocation of Nrf2 to the nucleus and reduces ROS production in EBV-transformed B cells.	ros	106-109	LMP1	Human gammaherpesvirus 4	34-45
17979497-7	2008	This review summarizes some recent findings that help us to understand the role of PAI-1 in the development of lung fibrosis and ROS/RNS in the regulation of PAI-1 expression during fibrogenesis.	ros	129-132	serpin family E member 1	Homo sapiens	158-163
31078159-8	2019	Pretreatment with 1microg/ml LPS prevented oxidative stress-induced EPCs apoptosis and ROS generation, which effects were abolished by TAK-242, a specific TLR4 antagonist.	ros	87-90	toll like receptor 4	Homo sapiens	155-159
18212534-8	2008	Addition of ROS-scavengers completely abrogated the synergistic induction of HIF-1 transcriptional activity by LPS and hypoxia, but neither inhibited HIF-1 transcriptional activity induced by hypoxia alone nor affected HIF-1alpha protein levels or HIF-1 DNA binding induced by hypoxia alone or hypoxia plus LPS.	ros	12-15	hypoxia inducible factor 1, alpha subunit	Mus musculus	219-229
31178664-7	2019	Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation.	ros	16-19	interleukin 1 alpha	Homo sapiens	96-104
17965319-0	2008	PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation.	ros	114-117	phosphodiesterase 5A, cGMP-specific	Mus musculus	0-5
17981627-4	2008	Inflammatory response after stroke suggests that cytokines (TNF-alpha, IL-1alpha/beta, IL-6), affect the phospholipid metabolism and subsequent production of eicosanoids, ceramide, and ROS that may potentiate brain injury.	ros	185-188	interleukin 1 alpha	Homo sapiens	71-80
17971295-11	2007	Moreover, we observed that ROS is an important upstream signal for AMPK activation during ginsenoside Rh2 treatment.	ros	27-30	Rh associated glycoprotein	Homo sapiens	102-105
18062818-3	2007	Here we investigated on the effect of N-acetylcysteine (NAC), on gp120-induced damage in human cultured astroglial cells and the possible contribution of gp120-related reacting oxygen species (ROS) in the imbalanced activity of glutamine synthase (GS), the enzyme that metabolizes glutamate into glutamine within astroglial cells playing a neuroprotective role in brain disorders.	ros	193-196	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	154-159
17639599-12	2007	In conclusion, high glucose induces GRO secretion and mRNA expression in activated rat microglia, which is mediated by the ROS, PKC, and NF-kappaB pathways.	ros	123-126	C-X-C motif chemokine ligand 1	Rattus norvegicus	36-39
17823777-8	2007	Transcript analysis of other ROS responsive genes in vtc2 and the triple mutant showed up to 20-fold induction after transition to HL, generally irrespective of genotype.	ros	29-32	GDP-L-galactose phosphorylase 1	Arabidopsis thaliana	53-57
17574212-7	2007	The intracellular ROS level of Prdx III O/E cell line was lower than D/N stable cell lines.	ros	18-21	peroxiredoxin 3	Mus musculus	31-39
17264981-8	2007	These results suggest that IGF-1 protects cardiomyocytes from HR injury via stabilizing mitochondria and reducing reactive oxidative species (ROS) damage.	ros	142-145	insulin-like growth factor 1	Rattus norvegicus	27-32
18183781-4	2007	The discovery of mitochondrial uncoupling proteins (UCPs) opened a new field of investigation, emphasizing the role of UCP1 or thermogenin, which generates an energy dissipation as heat and diminishing the amount of formed ATP and ROS and forcing the cell that expresses the UCP1 to oxidize more nutrients to obtain energy.	ros	231-234	uncoupling protein 1	Homo sapiens	119-123
18183781-4	2007	The discovery of mitochondrial uncoupling proteins (UCPs) opened a new field of investigation, emphasizing the role of UCP1 or thermogenin, which generates an energy dissipation as heat and diminishing the amount of formed ATP and ROS and forcing the cell that expresses the UCP1 to oxidize more nutrients to obtain energy.	ros	231-234	uncoupling protein 1	Homo sapiens	127-138
17694680-1	2007	The p47phox- and Rac 1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs.	ros	59-62	toll like receptor 4	Homo sapiens	145-149
17694680-1	2007	The p47phox- and Rac 1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs.	ros	59-62	toll like receptor 4	Homo sapiens	165-169
17258890-5	2007	Otherwise, TNFalpha and FasL stimulation led to radical oxygen species (ROS) generation and ASK1 (Apoptosis-signal-regulating-kinase-1) activation.	ros	72-75	Fas ligand	Homo sapiens	24-28
17258890-7	2007	Altogether, our results suggest that TNFalpha- and FasL-stimulated AML cell lytic induction is regulated by a signalling pathway involving sequentially, ROS generation, Trx oxidation, ASK1 activation, p38MAPK stimulation and GrB induction at mRNA and protein levels.	ros	153-156	Fas ligand	Homo sapiens	51-55
17403109-10	2007	In addition, the ROS production mediated by indoxyl sulfate was inhibited by the antioxidants vitamin C, vitamin E, and NAC.	ros	17-20	synuclein alpha	Homo sapiens	120-123
17349976-0	2007	ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3.	ros	0-3	hepcidin antimicrobial peptide	Homo sapiens	42-50
17349976-3	2007	Here, we tested the possibility that HIF-1 and ROS are involved in hepcidin regulation.	ros	47-50	hepcidin antimicrobial peptide	Homo sapiens	67-75
17349976-5	2007	On the other hand, ROS levels were significantly elevated in hypoxic HepG2 cells, and anti-oxidants prevented the hypoxic down-regulation of hepcidin.	ros	19-22	hepcidin antimicrobial peptide	Homo sapiens	141-149
17349976-8	2007	These results suggest that ROS repress the hepcidin gene by preventing C/EBPalpha and STAT-3 binding to hepcidin promoter during hypoxia.	ros	27-30	hepcidin antimicrobial peptide	Homo sapiens	43-51
17349976-8	2007	These results suggest that ROS repress the hepcidin gene by preventing C/EBPalpha and STAT-3 binding to hepcidin promoter during hypoxia.	ros	27-30	hepcidin antimicrobial peptide	Homo sapiens	104-112
17164239-5	2007	Exposure of cells expressing Nox5 to phorbol 12-myristate 13-acetate (PMA) resulted in a slow and sustained increase in ROS, which was markedly different from the rapid response to ionomycin.	ros	120-123	NADPH oxidase 5	Homo sapiens	29-33
16458553-3	2007	NAC is a thiol compound which by providing sulfhydryl groups, can act both as a precursor of reduced glutathione and as a direct ROS scavenger, hence regulating the redox status in the cells.	ros	129-132	synuclein alpha	Homo sapiens	0-3
29636842-7	2018	Thus, BMSCs exert beneficial effects on inhibiting NLRP3 inflammasome activation in macrophages primarily via both enhancing mitophagy and decreasing mitochondrial ROS.	ros	164-167	NLR family, pyrin domain containing 3	Mus musculus	51-56
29195919-11	2018	Thus, we demonstrate that p47phox S-glutathionylation plays an essential key role in the sustained ROS generation by human neutrophils.	ros	99-102	pleckstrin	Homo sapiens	26-29
29191461-9	2018	The protective HSP27-PI3K-AKT signaling pathway was activated only in PRA-treated cells and its inhibition increased ROS production and aggravated caspase-3 activity.	ros	117-120	heat shock protein family B (small) member 1	Homo sapiens	15-20
31178965-10	2019	Based on these data, we conclude that LPS impairs StAR expression via the ROS-induced downregulation of GATA4 and GATA6.	ros	74-77	interferon regulatory factor 6	Homo sapiens	38-41
16870178-5	2006	A missense genetic defect in the NDUFS4 subunit, putative substrate of PKA, suppressed, on the other hand, the activity of the complex and prevented ROS production.	ros	149-152	NADH:ubiquinone oxidoreductase subunit S4	Homo sapiens	33-39
31178965-10	2019	Based on these data, we conclude that LPS impairs StAR expression via the ROS-induced downregulation of GATA4 and GATA6.	ros	74-77	GATA binding protein 6	Homo sapiens	114-119
30324853-3	2019	Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs.	ros	23-26	colony stimulating factor 2	Homo sapiens	109-113
30324853-3	2019	Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs.	ros	23-26	colony stimulating factor 2	Homo sapiens	114-120
30324853-3	2019	Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs.	ros	23-26	colony stimulating factor 2	Homo sapiens	122-149
16716256-6	2006	Activation of caspase-9 and -3 during reoxygenation is believed to be triggered by the ROS formation at the time of reoxygenation.	ros	87-90	caspase 9	Homo sapiens	14-30
29391428-0	2018	beta-Sitosterol targets Trx/Trx1 reductase to induce apoptosis in A549 cells via ROS mediated mitochondrial dysregulation and p53 activation.	ros	81-84	thioredoxin	Homo sapiens	24-27
30324853-3	2019	Of note, autophagy and ROS, although strongly interconnected, have been separately reported to be induced by CSF2/GM-CSF (colony stimulating factor 2) and required for CSF2-IL4-driven monocyte in vitro differentiation into DCs.	ros	23-26	colony stimulating factor 2	Homo sapiens	168-172
29391428-4	2018	Moreover, generation of ROS species and subsequent DNA stand break were found upon BS treatment which was reversed by addition of ROS scavenger (NAC).	ros	24-27	synuclein alpha	Homo sapiens	145-148
16778989-2	2006	Proinflammatory cytokines such as GM-CSF and TNF-alpha prime ROS production by neutrophils through unknown mechanisms.	ros	61-64	colony stimulating factor 2	Homo sapiens	34-40
30579160-8	2019	In response to ROS generated by tobacco smoke increase the activity of antioxidant enzymes (SOD, GST, GPx and CAT), p &lt; 0.05.	ros	15-18	catalase isozyme 1	Nicotiana tabacum	110-113
16282349-3	2006	G-CSF stimulation showed a time- and dose-dependent increase in ROS production, correlating with activation of Lyn and Akt.	ros	64-67	colony stimulating factor 3	Homo sapiens	0-5
16282349-4	2006	Inhibition of Lyn, PI3-kinase, and Akt abrogated G-CSF-induced ROS production.	ros	63-66	colony stimulating factor 3	Homo sapiens	49-54
29391428-4	2018	Moreover, generation of ROS species and subsequent DNA stand break were found upon BS treatment which was reversed by addition of ROS scavenger (NAC).	ros	130-133	synuclein alpha	Homo sapiens	145-148
29391428-7	2018	Down-regulation of Trx/Trx1 reductase contributed to the BS induced ROS accumulation and mitochondrial mediated apoptotic cell death in A549 and NCI-H460 cells.	ros	68-71	thioredoxin	Homo sapiens	19-22
16282349-10	2006	G-CSF-induced ROS production was enhanced in bone marrow-derived neutrophils expressing G-CSFRdelta715, a truncated receptor.	ros	14-17	colony stimulating factor 3	Homo sapiens	0-5
30648791-5	2019	The Von Hippel-Lindau-deficient cells expressing FTO restores mitochondrial activity, induces oxidative stress and ROS production and shows impaired tumour growth, through increasing expression of PGC-1alpha by reducing m6A levels in its mRNA transcripts.	ros	115-118	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	49-52
16273420-7	2006	The radiosensitizing effect of dihydroartemisinin was blocked significantly by the free radical scavengers, NAC and TIRON, indicating association with dihydroartemisinin-induced ROS generation.	ros	178-181	synuclein alpha	Homo sapiens	108-111
29374159-10	2018	We further revealed that the repressed PKM2 induced autophagy, high NADPH/NADP ratio, and biomacromolecule production, but reduced ROS accumulation.	ros	131-134	pyruvate kinase M1/2	Homo sapiens	39-43
30887719-7	2019	Afterward, rotenone and LPS, which are activors of ROS and NF-kappaB, respectively, were used to stimulate HBx-overexpressing cells.	ros	51-54	X protein	Hepatitis B virus	107-110
29158087-0	2018	FABP4 induces asthmatic airway epithelial barrier dysfunction via ROS-activated FoxM1.	ros	66-69	fatty acid binding protein 4, adipocyte	Mus musculus	0-5
29158087-13	2018	Upregulated ROS induced by FABP4 was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.	ros	12-15	fatty acid binding protein 4, adipocyte	Mus musculus	27-32
16273420-9	2006	The radiosensitizing effect of dihydroartemisinin was also markedly enhanced by the addition of holotransferrin CONCLUSION: Taken together, our results strongly suggest that dihydroartemisinin triggers production of ROS and inhibits GST activity, leading to effective and therapeutically relevant radiosensitization of human glioma cells.	ros	216-219	glutathione S-transferase kappa 1	Homo sapiens	233-236
16195230-6	2005	In ROS 17/2.8 and MC3T3-E1 cells that contain endogenous Runx2, AML-1/ETO, which acts as a repressor of Runx2, significantly inhibited 1,25(OH)(2)D(3) induction of OPN transcription, OPN mRNA, and protein expression.	ros	3-6	runt related transcription factor 2	Mus musculus	57-62
30887719-9	2019	HBx inhibited the activity of NF-kappaB, inhibited the expression of HMGB1 and inhibited the production of ROS.	ros	107-110	X protein	Hepatitis B virus	0-3
30887719-11	2019	HBx inhibits the expression of HMGB1 and the generation of ROS via the NF-kappaB signaling pathway.	ros	59-62	X protein	Hepatitis B virus	0-3
30873019-13	2019	NBP pretreatment not only reduced pro-inflammatory molecules, but also suppressed NO release and ROS generation in BV-2 cells.	ros	97-100	NUBP iron-sulfur cluster assembly factor 1, cytosolic	Homo sapiens	0-3
16263910-9	2005	Thus, low intrinsic ascorbate and an impaired ascorbate-glutathione cycle in the vtc-1 mutant under salt stress probably induced a dramatic decrease in the reduced form of ascorbate, which resulted in both enhanced ROS contents and decreased NPQ in the vtc-1 mutant.	ros	215-218	Glucose-1-phosphate adenylyltransferase family protein	Arabidopsis thaliana	81-86
15806174-7	2005	Based on the above data, we suggest that HSP25 downregulates PKCdelta, which is a key molecule for radiation-induced ROS generation and mitochondrial-mediated caspase-dependent apoptotic events.	ros	117-120	heat shock protein family B (small) member 1	Homo sapiens	41-46
15780757-9	2005	In conclusion, Nox 2 stimulates muscle differentiation downstream of the PI 3-kinase/p38 MAPK pathway by activating the NF-kappaB/iNOS pathway via ROS generation.	ros	147-150	inositol-3-phosphate synthase 1	Homo sapiens	130-134
29316553-8	2018	Interestingly, excessive mitochondrial activation in Gas6-depleted MII oocytes caused ROS generation and glutathione (GSH) degradation via mitochondrial activation, such as elevated DeltaPsim and ATP production.	ros	86-89	growth arrest specific 6	Mus musculus	53-57
30813500-8	2019	Further study showed that pretreating infected cells with NAC (a ROS scavenger) decreased the intracellular ROS levels, increased the MMP, inhibited apoptosis, and promoted viral replication.	ros	65-68	synuclein alpha	Homo sapiens	58-61
29614490-11	2018	The impaired renal D1R function and increased GRK4 expression could be caused by increased reactive oxidative stress (ROS) induced by PM2.5 exposure.	ros	118-121	G protein-coupled receptor kinase 4	Rattus norvegicus	46-50
15773552-3	2005	In this study we have examined, whether the scavenging of reactive oxygen and reactive nitrogen species (ROS and RNS) is the major cause for thiol-mediated suppression of the HOX-1 induction by NO.	ros	105-108	heme oxygenase 1	Homo sapiens	175-180
30813500-8	2019	Further study showed that pretreating infected cells with NAC (a ROS scavenger) decreased the intracellular ROS levels, increased the MMP, inhibited apoptosis, and promoted viral replication.	ros	108-111	synuclein alpha	Homo sapiens	58-61
29637855-5	2018	Cytochrome P450 2E1 (CYP2E1) in MEOS is one of the major ROS generators in liver and is considered to be contributive to ALD.	ros	57-60	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	0-19
30736789-13	2019	HO-1 expression by STL or STB resulted from Nrf2 activation through ROS-dependent p38 activation.	ros	68-71	heme oxygenase 1	Homo sapiens	0-4
29637855-5	2018	Cytochrome P450 2E1 (CYP2E1) in MEOS is one of the major ROS generators in liver and is considered to be contributive to ALD.	ros	57-60	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	21-27
30726742-7	2019	beta2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1beta production, which promotes ILC3-derived IL-22.	ros	75-78	NLR family, pyrin domain containing 3	Mus musculus	114-119
15459075-5	2004	In the present study, we tested the hypothesis that central Ang II activates sympathetic outflow by stimulation of NAD(P)H oxidase and ROS in the CHF state.	ros	135-138	angiogenin	Oryctolagus cuniculus	60-63
28708282-9	2018	Functional studies demonstrated that MEG3 showed positive regulation on TUNEL-positive cells and ROS level.	ros	97-100	maternally expressed 3	Mus musculus	37-41
30726742-7	2019	beta2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1beta production, which promotes ILC3-derived IL-22.	ros	75-78	interleukin 22	Mus musculus	279-284
30711933-2	2019	Nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) and Park7 (DJ-1) are the main regulators of antioxidant enzymes eliminating reactive oxidative species (ROS).	ros	198-201	Parkinsonism associated deglycase	Homo sapiens	98-103
30711933-2	2019	Nuclear factor erythroid 2-related factor (Nrf2), Kelch-like ECH-associated protein 1 (Keap1) and Park7 (DJ-1) are the main regulators of antioxidant enzymes eliminating reactive oxidative species (ROS).	ros	198-201	Parkinsonism associated deglycase	Homo sapiens	105-109
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	ros	33-36	endothelial PAS domain protein 1	Mus musculus	62-72
15142843-11	2004	cTnI breakdown during ischemia is further increased in the presence of antioxidants, suggesting ROS generated during ischemia may play a cTnI protective role.	ros	96-99	troponin I3, cardiac type	Rattus norvegicus	0-4
30367545-4	2019	The present study first showed that OPN is highly expressed and secreted in activated PSCs driven by hypoxia, and this process is in a ROS-dependent manner; in addition, OPN was shown to be involved in the PSC-induced epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-like properties of pancreatic cancer cells (PCCs).	ros	135-138	secreted phosphoprotein 1	Homo sapiens	36-39
15142843-11	2004	cTnI breakdown during ischemia is further increased in the presence of antioxidants, suggesting ROS generated during ischemia may play a cTnI protective role.	ros	96-99	troponin I3, cardiac type	Rattus norvegicus	137-141
29383185-7	2017	Here we found that the increased Egr-1 expression was a consequence of G-1-mediated ROS-dependent ERK activation that were promptly reversed by the presence of the antioxidant n-acetyl-cysteine.	ros	84-87	early growth response 1	Homo sapiens	33-38
29383185-9	2017	The identified ROS/MAPK/Egr-1/BAX pathway as a potential off-target effect of the G-1 could be useful in implementing the pharmacological approach for ACC therapy.	ros	15-18	early growth response 1	Homo sapiens	24-29
30367545-4	2019	The present study first showed that OPN is highly expressed and secreted in activated PSCs driven by hypoxia, and this process is in a ROS-dependent manner; in addition, OPN was shown to be involved in the PSC-induced epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-like properties of pancreatic cancer cells (PCCs).	ros	135-138	secreted phosphoprotein 1	Homo sapiens	170-173
15064683-14	2004	CONCLUSIONS: Feeding n-3 fatty acids to rats with mutant rhodopsin transgenes significantly increased the levels of 22:6n-3 in ROS membranes, but had no effect on the rate of retinal degeneration.	ros	127-130	rhodopsin	Rattus norvegicus	57-66
30700698-5	2019	Here we pioneeringly elaborated that specific knockdown of cyclinB1 triggered autophagy via AMPK-ULK1-dependent signal pathway through the elevation of ROS, rather than ATP in the cell lines of CNE-1 and CNE-2.	ros	152-155	cyclin B1	Homo sapiens	59-67
14660625-11	2004	Heme oxygenase-1 expression was increased in rho(0) cells, and a heme oxygenase-1 inhibitor decreased the induction of MnSOD in rho(0) cells and their resistance against ROS donors.	ros	170-173	heme oxygenase 1	Homo sapiens	0-16
14660625-11	2004	Heme oxygenase-1 expression was increased in rho(0) cells, and a heme oxygenase-1 inhibitor decreased the induction of MnSOD in rho(0) cells and their resistance against ROS donors.	ros	170-173	heme oxygenase 1	Homo sapiens	65-81
29196684-0	2017	Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers.	ros	117-120	squalene epoxidase	Sus scrofa	0-18
29196684-7	2017	Moreover, mRNA expression levels of ROS scavengers, which affect meat quality by altering protein oxidation processes, were significantly downregulated by Sqle knockdown.	ros	36-39	squalene epoxidase	Sus scrofa	155-159
30700698-6	2019	Moreover, ROS scavengers demonstrated that the observed effect of cyclinB1 silencing on AMPK phosphorylation was ROS dependent.	ros	10-13	cyclin B1	Homo sapiens	66-74
30225556-4	2019	ROS and cell death in primary neuronal cultures were significantly reduced by TLR4 antagonists revealing that an indirect inflammatory mechanism involving cytokines produced by glial cells makes a major contribution to neuronal death.	ros	0-3	toll like receptor 4	Homo sapiens	78-82
15053182-3	2004	Increased stress in normally perfused border zone myocardium results in the production of cytokines and ROS, which in turn stimulate myocyte apoptosis, disruption of the ECM, and fibrosis.	ros	104-107	multimerin 1	Homo sapiens	170-173
12493091-11	2002	In vivo inhibition of iNOS or ODC decreased ROS production induced by GLN and ARG.	ros	44-47	ornithine decarboxylase 1	Rattus norvegicus	30-33
30889411-5	2019	Elevation in extracellular ROS and altered expression of SGK-1 indicates the role of DAF-16 during UV-A exposure.	ros	27-30	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	85-91
18494887-7	2002	ROS was evaluated on the blood serum and on IL-3 stimulated human leukocytes by ROS Meter System at 505 nm.	ros	0-3	interleukin 3	Homo sapiens	44-48
28947420-1	2017	MTH1 helps prevent misincorporation of ROS-damaged dNTPs into genomic DNA; however, there is little understanding of how MTH1 itself is regulated.	ros	39-42	nudix hydrolase 1	Homo sapiens	0-4
30571927-9	2019	One was from ROS-dependent activation of ATM via AMPK-ULK1-ATG13-Beclin1/ATG5.	ros	13-16	ATM serine/threonine kinase	Homo sapiens	41-44
28823591-7	2017	Overexpression of G6PD increased levels of NADPH and reduced form of glutathione (rGSH), and ameliorated ROS-induced macromolecular damage.	ros	105-108	glucose-6-phosphate dehydrogenase 2	Mus musculus	18-22
18494887-7	2002	ROS was evaluated on the blood serum and on IL-3 stimulated human leukocytes by ROS Meter System at 505 nm.	ros	80-83	interleukin 3	Homo sapiens	44-48
30878663-11	2019	Overexpression of CLPP inhibited senescence in vitro, by reducing mitochondrial ROS and altering oxygen consumption.	ros	80-83	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Sus scrofa	18-22
12175780-8	2002	However, the activity of 1alpha,25(OH)2-3-epi-D3 when compared to 1alpha,25(OH)2D3 in generating VDR-mediated transcriptional activity in ROS 17/2.8 cells transfected with human osteocalcin VDRE/growth hormone gene construct, was significantly reduced.	ros	138-141	vitamin D receptor	Rattus norvegicus	97-100
29163585-4	2017	CRK36OE plants exhibited increased hypersensitive cell death and ROS burst in response to avirulent pathogens.	ros	65-68	cysteine-rich RLK (RECEPTOR-like protein kinase) 36	Arabidopsis thaliana	0-5
29163585-10	2017	We propose that CRK36, together with BIK1 and NADPH oxidases, may form a positive activation loop that enhances ROS burst and leads to the promotion of stomatal immunity.	ros	112-115	cysteine-rich RLK (RECEPTOR-like protein kinase) 36	Arabidopsis thaliana	16-21
28946937-6	2017	The ROS scavenger N-acetylcysteine inhibited CLB2.0-induced IL-6 secretion, thereby decreasing the CLB2.0-induced MUC5AC expression, whereas CLB2.0-induced MUC1 expression increased.	ros	4-7	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	114-120
11948463-4	2002	Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs.	ros	175-178	selectin E	Homo sapiens	205-215
28444510-7	2017	We provide new evidence that Yak1, Rim15 and Mck1 kinases cooperate to activate H2O2-scanvenging activities, thus limiting the levels of ROS in cells entering quiescence.	ros	137-140	serine/threonine protein kinase YAK1	Saccharomyces cerevisiae S288C	29-33
29961191-7	2019	At the molecular level, upregulation of Mst1 promoted ROS production, reduced mitochondrial membrane potential, facilitated the leakage of mitochondrial pro-apoptotic factors into the nucleus, and activated the caspase-9-related apoptotic pathway in reperfused cardiomyocytes.	ros	54-57	macrophage stimulating 1	Homo sapiens	40-44
28806703-0	2017	NOX4-mediated ROS production induces apoptotic cell death via down-regulation of c-FLIP and Mcl-1 expression in combined treatment with thioridazine and curcumin.	ros	14-17	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	92-97
28959260-5	2017	Nrf2- or PKR/Akt-deficient macrophages exhibited increased levels of ROS/RNS and reduced expression of Sod1 Nrf2-dependent gene and reduced parasite load.	ros	69-72	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	9-12
11799110-3	2002	In contrast, inhibiting the phosphatidylinositol 3-kinase (PI3K) pathway with the drug LY294002, a dominant negative mutant of PI3K, Deltap85, or the phosphatidylinositol phosphatase PTEN (phosphatase and tensin homologue deleted in chromosome ten) resulted in a dramatic reduction of v-Ros- and epidermal growth factor receptor-Ros-promoted anchorage-independent growth of chicken embryo fibroblasts and NIH3T3 cells, respectively.	ros	287-290	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	28-57
11752025-6	2002	Exogenous ROS caused a concentration-dependent, &gt;10-fold induction of GM-CSF mRNA after 4 h. A &gt;50-fold increase in GM-CSF protein release in podocytes that had been stimulated with ROS could be detected.	ros	10-13	colony stimulating factor 2	Homo sapiens	73-79
11752025-6	2002	Exogenous ROS caused a concentration-dependent, &gt;10-fold induction of GM-CSF mRNA after 4 h. A &gt;50-fold increase in GM-CSF protein release in podocytes that had been stimulated with ROS could be detected.	ros	10-13	colony stimulating factor 2	Homo sapiens	122-128
11752025-6	2002	Exogenous ROS caused a concentration-dependent, &gt;10-fold induction of GM-CSF mRNA after 4 h. A &gt;50-fold increase in GM-CSF protein release in podocytes that had been stimulated with ROS could be detected.	ros	188-191	colony stimulating factor 2	Homo sapiens	73-79
11752025-6	2002	Exogenous ROS caused a concentration-dependent, &gt;10-fold induction of GM-CSF mRNA after 4 h. A &gt;50-fold increase in GM-CSF protein release in podocytes that had been stimulated with ROS could be detected.	ros	188-191	colony stimulating factor 2	Homo sapiens	122-128
30261287-14	2018	Targeting TXNIP-ROS-Wnt is a promising strategy in improving the prognosis.	ros	16-19	wingless-type MMTV integration site family, member 3A	Mus musculus	20-23
11752025-8	2002	The ROS scavengers dimethyl-thio-urea and pyrrolidone-dithio-carbamate strongly inhibited increased GM-CSF production induced by ROS.	ros	4-7	colony stimulating factor 2	Homo sapiens	100-106
11752025-8	2002	The ROS scavengers dimethyl-thio-urea and pyrrolidone-dithio-carbamate strongly inhibited increased GM-CSF production induced by ROS.	ros	129-132	colony stimulating factor 2	Homo sapiens	100-106
11752025-9	2002	GM-CSF release was also induced when internal ROS production was triggered with NADH, whereas H2O2 had only a small effect.	ros	46-49	colony stimulating factor 2	Homo sapiens	0-6
11752025-12	2002	Activation of the transcription factor nuclear factor-kappaB (NF-kappaB) but not activator protein-1 was involved in the upregulation of ROS-induced GM-CSF production.	ros	137-140	colony stimulating factor 2	Homo sapiens	149-155
28912535-7	2017	Blockade of sigma-1 receptor significantly inhibited the generation of ROS and activation of the MAPK and Akt pathways.	ros	71-74	sigma non-opioid intracellular receptor 1	Mus musculus	12-28
11752025-13	2002	The data indicate that GM-CSF is differentially expressed by ROS in podocytes.	ros	61-64	colony stimulating factor 2	Homo sapiens	23-29
30365930-13	2018	treatment 10 min before reperfusion decreased the level of TNF-alpha following with a negatively regulating the RIP3 induced phosphor-MLKL/CaMKII signaling, thus significantly reduced ROS production and cardiomyocyte necroptosis and ameliorated cardiac function.	ros	184-187	calcium/calmodulin-dependent protein kinase II alpha	Mus musculus	139-145
11752025-14	2002	ROS also partially mediate the effects of PMA and IL-1 on podocyte GM-CSF production.	ros	0-3	interleukin 1 alpha	Homo sapiens	50-54
11752025-14	2002	ROS also partially mediate the effects of PMA and IL-1 on podocyte GM-CSF production.	ros	0-3	colony stimulating factor 2	Homo sapiens	67-73
11752025-15	2002	Because GM-CSF can enhance glomerular inflammation and induces mesangial proliferation, these data might provide further insight into the mechanisms of ROS-induced glomerular injury.	ros	152-155	colony stimulating factor 2	Homo sapiens	8-14
30370500-2	2018	Impairment of mitochondria, endoplasmic reticulum, autophagy and intracellular trafficking proper function has been suggested to be caused by alpha-synuclein toxicity, which is also associated with the higher levels of ROS found in the aged brain and in PD.	ros	219-222	synuclein alpha	Homo sapiens	142-157
12112014-8	2002	A monoclonal antibody against NF-YA, a CCAAT box-binding transcription factor, inhibited formation of DNA-NF-Y protein complex in gel shift assays formed by nuclear extracts of ROS 17/2.8 cells.	ros	177-180	nuclear transcription factor Y subunit alpha	Rattus norvegicus	30-35
28574504-4	2017	We further demonstrate that NADPH oxidase 2 (NOX2)-dependent ROS production is upstream to ATM activation and is essential during this process.	ros	61-64	ATM serine/threonine kinase	Homo sapiens	91-94
30125683-7	2018	These events are found to be reinforced by PKC, MAPK, and ROS-dependent GPVI pathways.	ros	58-61	glycoprotein VI platelet	Homo sapiens	72-76
28437599-12	2017	Mitochondrial ROS regulated both HBD-3-induced IL-8 production and cell apoptosis.	ros	14-17	defensin beta 103B	Homo sapiens	33-38
30555239-9	2018	Molecular experiments showed that Mst1 overexpression mediated mitochondrial damage, as evidenced by decreased ATP production, increased ROS generation, more cyt-c translocation from the mitochondria into the cytoplasm and nucleus, and activated the caspase-9-related apoptotic pathway.	ros	137-140	macrophage stimulating 1	Homo sapiens	34-38
11952088-6	2002	The LCA1-linked mutations are distributed over almost the entire ROS-GCI coding sequence but the CORD6-linked mutations are restricted to three positions, E786, R787 and T788, located within the putative ROS-GC1 dimerization domain.	ros	65-68	guanylate cyclase 2D, retinal	Homo sapiens	4-8
10884379-16	2000	Together, our results strongly suggest that after activation of PDE by light/GTP, Pgamma is phosphorylated by Cdk5 and the phosphorylated Pgamma inhibits GTP/Talpha-activated PDE, even in the presence of GTP/Talpha in ROS.	ros	218-221	cyclin dependent kinase 5	Homo sapiens	110-114
29088725-0	2017	Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis via the ROS-MST1 pathway.	ros	88-91	macrophage stimulating 1	Homo sapiens	92-96
30266652-8	2018	Furthermore, the reduction in SNCA levels by the guide RNA (gRNA)-dCas9-DMNT3A system rescued disease-related cellular phenotype characteristics of the SNCA triplication hiPSC-derived dopaminergic neurons, e.g., mitochondrial ROS production and cellular viability.	ros	226-229	synuclein alpha	Homo sapiens	30-34
28774348-12	2017	We present experimental data indicating that the cytosolic increase in ROS levels is responsible for the enhanced proliferation of FHC-silenced cells, while the higher migration rate is attributable to a dysregulation of the CXCR4/CXCL12 axis.	ros	71-74	low density lipoprotein receptor	Homo sapiens	131-134
10920219-1	2000	The role of epidermal growth factor receptors (EGF-R) in osteogenic cell differentiation was investigated using preosteoblastic MC3T3-E1 (MC3T3) cells and osteoblast-like ROS 17/2.8 (ROS) cells.	ros	171-174	epidermal growth factor receptor	Mus musculus	47-52
10920219-4	2000	On the other hand, ROS cells with high expression levels of osteoblast markers and no EGF-R, after being transfected with human EGF-R cDNA (EROS cells), expressed numerous EGF-binding sites as well as EGF-R mRNA and protein; in the process, they ceased to express osteoblast markers, indicating their dedifferentiation into osteoprogenitor cells.	ros	19-22	epidermal growth factor	Mus musculus	128-131
10920219-5	2000	Both MC3T3 and EROS cells showed increased cell growth in response to EGF, whereas ROS cells did not.	ros	16-19	epidermal growth factor	Mus musculus	70-73
28774348-13	2017	CONCLUSIONS: Our findings indicate that induction of EMT, increased migration and survival depend, in MCF-7 and H460 cells, on the release of FHC control on two pathways, namely the iron/ROS metabolism and CXCR4/CXCL12 axis.	ros	187-190	low density lipoprotein receptor	Homo sapiens	142-145
30290280-7	2018	ROS quantification of these compounds showed oxidative stress to cancerous cells and molecular docking study showed hydrogen bonding, charge or polar and van der Waals interactions with the active site residues of MARK4.	ros	0-3	microtubule affinity regulating kinase 4	Homo sapiens	214-219
29198560-8	2017	RESULTS: Nf1 knockdown enhanced the cellular capacities of proliferation, migration and invasion, promoted ROS generation, decreased the expression of epithelial surface marker E-cadherin, and up-regulated several EMT-associated molecules in Schwann cells.	ros	107-110	neurofibromin 1	Mus musculus	9-12
29198560-11	2017	CONCLUSIONS: Our results clearly reveal that ROS overproduction is responsible for Nf1 deficiency-induced EMT and plays a crucial role in NF1 tumor growth.	ros	45-48	neurofibromin 1	Mus musculus	83-86
29198560-11	2017	CONCLUSIONS: Our results clearly reveal that ROS overproduction is responsible for Nf1 deficiency-induced EMT and plays a crucial role in NF1 tumor growth.	ros	45-48	neurofibromin 1	Mus musculus	138-141
28575806-0	2017	Phytol induces ROS mediated apoptosis by induction of caspase 9 and 3 through activation of TRAIL, FAS and TNF receptors and inhibits tumor progression factor Glucose 6 phosphate dehydrogenase in lung carcinoma cell line (A549).	ros	15-18	caspase 9	Homo sapiens	54-69
10491222-0	1999	Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I.	ros	29-32	insulin-like growth factor 1	Rattus norvegicus	60-65
9788905-6	1998	The reactive substances at these biosurfaces not only represent an important protective system against oxidizing environments, but products of their reactions with ROS/RNS may also serve as biomarkers of environmental oxidative stress.	ros	164-167	FAM20C golgi associated secretory pathway kinase	Homo sapiens	168-171
9754575-3	1998	We show that RAG-1-/-, TCRbeta-/- , and p56lck-/- mice lack thymocyte ROS formation with epithelial cells, macrophages, or dendritic cells.	ros	70-73	T cell receptor beta chain	Mus musculus	23-30
9378108-5	1997	VEGF up-regulation was also observed in ROS-17/2.8 and OHS-4 osteoblast-like cells but not in MCF-7 and MDA-MB231 breast carcinoma cells.	ros	40-43	vascular endothelial growth factor A	Rattus norvegicus	0-4
30352992-8	2018	In contrast, the simultaneous stimulation of TLR2, TLR4 and TLR7/8 drives high levels of ROS, GSDMD cleavage and faster IL-1beta secretion.	ros	89-92	toll like receptor 4	Homo sapiens	51-55
30443192-1	2018	Our previous studies have shown that DJ-1 play important roles in progression of liver diseases through modulating hepatic ROS production and immune response, but its role in hepatic steatosis remains obscure.	ros	123-126	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	37-41
9373734-1	1997	In this paper, we examine the effects of SPG, which is a well known BRM, both in vivo and in vitro on the neutrophilic ROS production and the serum opsonic activity by the chemiluminescence technique using luminol as a probe.	ros	119-122	SPG16	Homo sapiens	41-44
9373734-5	1997	The addition of supernatants at a lower concentration of SPG (0.01 mg/ml) with mitogens showed significant preventive effects on the neutrophilic ROS production for the duration of incubation.	ros	146-149	SPG16	Homo sapiens	57-60
28455244-7	2017	Survival in low pH is reduced upon depletion of GOT1 due to increased intracellular ROS levels.	ros	84-87	glutamic-oxaloacetic transaminase 1	Homo sapiens	48-52
30337875-7	2018	We further demonstrated that this GPX4 activator can decrease the intracellular ROS level and suppress ferroptosis.	ros	80-83	glutathione peroxidase 4	Homo sapiens	34-38
28455244-8	2017	Thus, GOT1 plays an important role in energy metabolism and ROS balance in chronic acidosis stress.	ros	60-63	glutamic-oxaloacetic transaminase 1	Homo sapiens	6-10
8913867-4	1996	To determine whether the 1 beta-hydroxymethyl analogs induced a VDR-mediated transcription, we tested the induction of reporter gene expression through the osteocalcin vitamin D response element (VDRE) in ROS 17/2.8 cells and the induction of binding activity of VDR to VDRE in COS-1 cells.	ros	205-208	vitamin D receptor	Rattus norvegicus	64-67
8913867-4	1996	To determine whether the 1 beta-hydroxymethyl analogs induced a VDR-mediated transcription, we tested the induction of reporter gene expression through the osteocalcin vitamin D response element (VDRE) in ROS 17/2.8 cells and the induction of binding activity of VDR to VDRE in COS-1 cells.	ros	205-208	vitamin D receptor	Rattus norvegicus	196-199
8684002-2	1996	We have studied three B-NHL cell lines (DoHH2, VAL and ROS 50) and show that concurrent activation of BCL2 and MYC may follow translocation of both oncogenes to the same IGH allele.	ros	55-58	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-114
7588294-2	1995	The present study was performed to investigate the effects of interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and interferon-gamma (IFN-gamma) on the expression of inducible NO-synthase (iNOS) and to measure high-output production of NO by primary rat osteoblasts and osteoblastic cell lines ROS 17/2.8, MC3T3-E1 and MG-63.	ros	317-320	interferon gamma	Rattus norvegicus	157-166
28270496-9	2017	Targeting the ROS/Jab1/Trx pathway could be beneficial in the treatment of AML-M5.	ros	14-17	thioredoxin	Homo sapiens	23-26
30107367-11	2018	In conclusion, our study provided evidence that the protective effect of CK on diabetes-induced renal injury is associated with down-regulating the expression of NADHP oxidase, and inhibition of ROS-mediated activation of NLRP3 inflammasome and NF-kappaB/p38 signaling pathway, suggesting its therapeutic implication for renal inflammation.	ros	195-198	NLR family, pyrin domain containing 3	Mus musculus	222-227
28591670-9	2017	Western blot analysis showed that compound 5b induces G2/M phase arrest via ROS mediated DNA-damage, which in turn, induces phosphorylation of Chk1/Cdc25c/Cdc2 pathway.	ros	76-79	cell division cycle 25C	Homo sapiens	148-154
28591670-9	2017	Western blot analysis showed that compound 5b induces G2/M phase arrest via ROS mediated DNA-damage, which in turn, induces phosphorylation of Chk1/Cdc25c/Cdc2 pathway.	ros	76-79	cyclin dependent kinase 1	Homo sapiens	148-152
28765565-9	2017	Moreover, TERT suppressed cisplatin-induced apoptosis and improved mitochondrial function via alleviating intracellular ROS in osteosarcoma cells.	ros	120-123	telomerase reverse transcriptase	Homo sapiens	10-14
7530648-6	1995	With 100 nM corticosterone treatment for 24 h, inhibition of the adhesion of ROS 17/2.8 cells and primary osteoblasts to fibronectin was 75 +/- 10% and 50 +/- 8%, and inhibition of adhesion to collagen was 31 +/- 10% and 65 +/- 5%, respectively.	ros	77-80	fibronectin 1	Rattus norvegicus	121-132
30040158-0	2018	EBV up-regulates PD-L1 on the surface of primary monocytes by increasing ROS and activating TLR signaling and STAT3.	ros	73-76	CD274 molecule	Homo sapiens	17-22
7950503-2	1994	In rat (UMR 106, ROS 17/2.8) and human (MG-63) osteoblastic cell lines and in isolated fetal rat osteoblasts TGF beta caused a comparable increase in vitamin D receptor (VDR) level.	ros	17-20	vitamin D receptor	Rattus norvegicus	150-168
28341289-5	2017	Furthermore, high dose LPS (&gt;=10mug/ml) induced cell death involving mitochondrial pathways, death receptors as well as p21-dependent DNA damage response activation mediated by ROS generation and TNF-alpha release.	ros	180-183	H3 histone pseudogene 16	Homo sapiens	123-126
30298051-10	2018	Results: Pretreatment of VSMCs with AGEs-BSA increased the expression of thioredoxin-interacting protein (TXNIP) by inhibiting that of miR-146a, resulting in enhanced ROS production and VSMC calcification.	ros	167-170	microRNA 146a	Rattus norvegicus	135-143
28743875-7	2017	By employing promoter-linked reporter assay, we showed that HCV upregulated DR6 via ROS-mediated NF-kappaB pathway.	ros	84-87	TNF receptor superfamily member 21	Homo sapiens	76-79
9397948-1	1994	In this study, we examined the effect of activation of protein kinase C (PKC) pathways on the regulation of 1,25-dihydroxyvitamin D receptors (VDR) in rat osteosarcoma (ROS) 17/2.8 cells.	ros	169-172	vitamin D receptor	Rattus norvegicus	143-146
9397948-2	1994	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) resulted in a time- and dose-dependent increase in VDR expression in ROS cells.	ros	130-133	vitamin D receptor	Rattus norvegicus	112-115
9397948-4	1994	Oleoyl acetyl glycerol (OAG), a synthetic diacylglycerol, stimulated VDR up-regulation in ROS cells.	ros	90-93	vitamin D receptor	Rattus norvegicus	69-72
9397948-6	1994	We next examined the interaction of 1,25(OH)2D3 and PKC activation by PMA on the regulation of VDR in ROS cells.	ros	102-105	vitamin D receptor	Rattus norvegicus	95-98
9397948-10	1994	In contrast, co-treatment of ROS cells with PMA and 1,25(OH)2D3 resulted in a synergistic 10-fold induction of VDR mRNA and the appearance of a 7.2 kb VDR transcript.	ros	29-32	vitamin D receptor	Rattus norvegicus	111-114
28757478-6	2017	More recent studies have revealed that MST1/2 mediates the innate immune response against pathogens or viruses, especially on macrophage phagocytosis as well as cytokines and ROS production.	ros	175-178	macrophage stimulating 1	Homo sapiens	39-45
9397948-10	1994	In contrast, co-treatment of ROS cells with PMA and 1,25(OH)2D3 resulted in a synergistic 10-fold induction of VDR mRNA and the appearance of a 7.2 kb VDR transcript.	ros	29-32	vitamin D receptor	Rattus norvegicus	151-154
30237394-10	2018	Mechanistically, increased mitochondrial fission and subsequent ROS production was found to be involved in the promotion of growth and metastasis by MTP18 in HCC cells.	ros	64-67	mitochondrial fission process 1	Homo sapiens	149-154
9397948-11	1994	VDR protein was also synergistically up-regulated by combined PMA and 1,25(OH)2D3 treatment of ROS cells.	ros	95-98	vitamin D receptor	Rattus norvegicus	0-3
7902818-3	1993	At the same time we have revealed a complex of p26 with an unidentified protein, presumably RK, in bovine ROS.	ros	106-109	recoverin	Bos taurus	47-50
28700690-4	2017	Human DGAT2 activity was considerably inhibited not only by thiol-modifying reagents (NEM and IA) but also by ROS-related chemicals (H2O2 and beta-lapachone), while human DGAT1 and GPAT1 were little affected.	ros	110-113	diacylglycerol O-acyltransferase 2	Homo sapiens	6-11
28700690-4	2017	Human DGAT2 activity was considerably inhibited not only by thiol-modifying reagents (NEM and IA) but also by ROS-related chemicals (H2O2 and beta-lapachone), while human DGAT1 and GPAT1 were little affected.	ros	110-113	diacylglycerol O-acyltransferase 1	Homo sapiens	171-176
30275708-9	2018	Furthermore, Phen and Met were associated with the increased level of ROS of cell mitochondrial, and ROS inhibitor NAC could significantly rescue the cell death induced by Phen and Met.	ros	101-104	synuclein alpha	Homo sapiens	115-118
28744297-5	2017	The ROS levels increased in DEWAX OX leaves, but decreased in dewax relative to WT leaves.	ros	4-7	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	28-33
28744297-5	2017	The ROS levels increased in DEWAX OX leaves, but decreased in dewax relative to WT leaves.	ros	4-7	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	62-67
28694518-8	2017	Therefore, PDK1 appears to contribute to HSC function partially via regulating ROS levels.	ros	79-82	fucosyltransferase 1 (H blood group)	Homo sapiens	41-44
28661486-2	2017	ROS production from mitochondria activates MAP3 kinases, such as MLK3 and ASK1, which continue to activate a pathway to sustain JNK activation, and amplifies the toxic effect of acetaminophen (APAP) and TNF/galactosamine (TNF/GalN).	ros	0-3	mitogen-activated protein kinase kinase kinase 5	Mus musculus	74-78
28528741-0	2017	In vitro immune toxicity of ochratoxin A in porcine alveolar macrophages: A role for the ROS-relative TLR4/MyD88 signaling pathway.	ros	89-92	toll like receptor 4	Homo sapiens	102-106
28528741-6	2017	NAC, a commonly used antioxidant, alleviated the OTA-induced increase of ROS production, apoptosis, and LDH release and decrease of cell viability.	ros	73-76	synuclein alpha	Homo sapiens	0-3
28528741-9	2017	These data indicate that OTA induced immune toxicity via ROS-relative TLR4/MyD88 signaling pathway in PAMs.	ros	57-60	toll like receptor 4	Homo sapiens	70-74
28598396-5	2017	At the same time Nrf2/HO-1 pathway is up-regulated by ROS to protect placenta cells from oxidative damage.	ros	54-57	heme oxygenase 1	Homo sapiens	22-26
28598396-6	2017	In DON-treated BeWo cells, the level of ROS has time-effect and dose-effect relationships with HO-1 expression.	ros	40-43	heme oxygenase 1	Homo sapiens	95-99
28396567-4	2017	We also provide evidence that inactivation of PIKfyve by the selective inhibitor STA suppresses excessive mitochondrial ROS production and apoptosis through a SIRT3-dependent pathway in cardiomyoblasts.	ros	120-123	autosomal striping	Mus musculus	81-84
28220193-8	2017	MiR-4485 modulated mitochondrial complex I activity, the production of ATP, ROS levels, caspase-3/7 activation, and apoptosis.	ros	76-79	microRNA 4485	Homo sapiens	0-8
28545052-8	2017	Here, we proposed a simple model where both BRL3 and AtRGS1 are part of a fine-tuning mechanism sensing glucose and flg22 to prevent excess ROS burst and control growth inhibition.	ros	140-143	REGULATOR OF G-PROTEIN SIGNALING 1	Arabidopsis thaliana	53-59
28216619-10	2017	Furthermore, 15d-PGJ2 pretreatment activated Nrf2 and inhibited a ROS/HIF1alpha/BNIP3 pathway in the livers.	ros	66-69	hypoxia inducible factor 1, alpha subunit	Mus musculus	70-79
7908582-1	1993	We have shown by receptor-binding analyses that the beta-2 adrenergic receptor is present on rat ROS 17/2.8 osteoblast-like cells.	ros	97-100	adrenoceptor beta 2	Rattus norvegicus	52-78
8456584-4	1993	Both ROS 17/2.8 and ROS 25/1 attached to similar molar amounts of substrate with the same preference order: FN &gt; LN &gt; Col I &gt; or = Col IV.	ros	20-23	fibronectin 1	Rattus norvegicus	108-110
8456584-6	1993	ROS 25/1 attached less effectively than ROS 17/2.8 to most non-FN substrates.	ros	0-3	fibronectin 1	Rattus norvegicus	63-65
8456584-6	1993	ROS 25/1 attached less effectively than ROS 17/2.8 to most non-FN substrates.	ros	40-43	fibronectin 1	Rattus norvegicus	63-65
1320001-5	1992	Also, AMG inhibited 10(-9) M 1,25(OH)2D3-induced up-regulation of vitamin D receptor in ROS 17/2.8 cells.	ros	88-91	vitamin D receptor	Rattus norvegicus	66-84
2023920-5	1991	Here we show that pEnkA mRNA is abundant in normal calvaria-derived cells and in osteosarcoma-derived cell lines ROS 17/2.8 and ROS 25/1.	ros	113-116	proenkephalin	Rattus norvegicus	18-23
2023920-5	1991	Here we show that pEnkA mRNA is abundant in normal calvaria-derived cells and in osteosarcoma-derived cell lines ROS 17/2.8 and ROS 25/1.	ros	128-131	proenkephalin	Rattus norvegicus	18-23
2023920-7	1991	pEnkA expression in ROS cells is decreased by osteogenin, an osteoinductive factor, and by the calcium-regulating hormone, 1,25-dihydroxyvitamin D3, whereas the osteoblastic phenotype marker, alkaline phosphatase, is increased by these factors.	ros	20-23	proenkephalin	Rattus norvegicus	0-5
2023920-8	1991	These results together with the inhibitory effects of pEnkA-derived peptides on alkaline phosphatase activity in ROS 17/2.8 cells suggest that pEnkA is involved in bone development and provide a model system for further analysis of pEnkA expression during this process.	ros	113-116	proenkephalin	Rattus norvegicus	54-59
2023920-8	1991	These results together with the inhibitory effects of pEnkA-derived peptides on alkaline phosphatase activity in ROS 17/2.8 cells suggest that pEnkA is involved in bone development and provide a model system for further analysis of pEnkA expression during this process.	ros	113-116	proenkephalin	Rattus norvegicus	143-148
2023920-8	1991	These results together with the inhibitory effects of pEnkA-derived peptides on alkaline phosphatase activity in ROS 17/2.8 cells suggest that pEnkA is involved in bone development and provide a model system for further analysis of pEnkA expression during this process.	ros	113-116	proenkephalin	Rattus norvegicus	143-148
2387335-5	1990	While ROS length showed no appreciable change with age, rhodopsin per ROS length increased by 31% between 30 and 60 days of age and by 48% between 30 and 90 days.	ros	70-73	rhodopsin	Rattus norvegicus	56-65
2387335-7	1990	However, the 12% increase in ROS diameter between 30 and 90 days of age may partially account for the rhodopsin difference.	ros	29-32	rhodopsin	Rattus norvegicus	102-111
2387335-8	1990	These findings demonstrate an age-dependent association between greater rhodopsin per ROS length and increased susceptibility to retinal light damage.	ros	86-89	rhodopsin	Rattus norvegicus	72-81
33785100-6	2021	The results proved the presence of ROS that triggered the intrinsic apoptotic pathway, which was confirmed through a decrease in (Bcl-2), the release of cytochrome c, activation of caspase-9, and caspase-3.	ros	35-38	caspase 9	Homo sapiens	181-190
32858189-9	2020	Intriguingly, ROS scavenger, Vitamin C, could rescue ET-1-induced chondrocyte senescence in vitro associated with restoration of mitochondrial dynamics.	ros	14-17	endothelin 1	Mus musculus	53-57
34968619-12	2022	Therefore, our findings reveal that CoCl2 induced ROS affected the m6A modification of apoptosis-related genes by decreasing the expression of FTO, thereby resulting in the activation of apoptosis.	ros	50-53	FTO alpha-ketoglutarate dependent dioxygenase	Homo sapiens	143-146
34847428-0	2022	Euphoesulatin A prevents osteoclast differentiation and bone loss via inhibiting RANKL-induced ROS production and NF-kappaB and MAPK signal pathways.	ros	95-98	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	81-86
34875574-8	2022	LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling.	ros	190-193	interleukin 1 alpha	Homo sapiens	29-37
34979450-0	2022	Induction of autophagy via the ROS-dependent AMPK-mTOR pathway protects copper-induced spermatogenesis disorder.	ros	31-34	mechanistic target of rapamycin kinase	Mus musculus	50-54
34785090-0	2022	Corrigendum to "TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARgamma-SIRT1 feedback loop in human bladder cancer cells" (Cancer Lett.	ros	59-62	sirtuin 1	Mus musculus	92-97
34563600-8	2022	Normal leptin secretion follows a rhythm, and alteration in the lifestyle leads to hormonal imbalances and increases ROS generation leading to oxidative stress.	ros	117-120	leptin	Homo sapiens	7-13
34863979-5	2022	NOX4-stimulated ROS generation led to JNK-mediated phosphorylation of cytosolic HuR at Ser221, thereby increasing TNF-alpha protein expression by stabilizing TNF-alpha mRNA.	ros	16-19	ELAV like RNA binding protein 1	Homo sapiens	80-83
30151521-9	2018	In the in vitro experiment, 6-G reset the IL-4-induced arginase+ M2 cells toward iNOS+ M1 cells and exhibited reduced levels of arginase 1 and ROS and elevated levels of L-arginine and NO.	ros	143-146	interleukin 4	Mus musculus	42-46
30279690-0	2018	Physiological Stimuli Induce PAD4-Dependent, ROS-Independent NETosis, With Early and Late Events Controlled by Discrete Signaling Pathways.	ros	45-48	peptidyl arginine deiminase 4	Homo sapiens	29-33
34462274-5	2022	Mechanistically, dynamin-related protein 1 (DRP1)-dependent excessive mitochondrial fragmentation in HSC/Ps led to excessive ROS production, induced inflammatory signaling activation, and promoted subsequent dysplasia formation and impairment of granulopoiesis.	ros	125-128	dynamin 1 like	Homo sapiens	17-42
34462274-5	2022	Mechanistically, dynamin-related protein 1 (DRP1)-dependent excessive mitochondrial fragmentation in HSC/Ps led to excessive ROS production, induced inflammatory signaling activation, and promoted subsequent dysplasia formation and impairment of granulopoiesis.	ros	125-128	dynamin 1 like	Homo sapiens	44-48
34742454-2	2022	In this study, a carboxymethyl chitosan-based pH/hypoxia-responsive and gamma-Fe2O3/isosorbide dinitrate carrying micelle was designed, and it could catalyze endogenous H2O2 to generate oxygen and relieve hypoxia in TME, so as to relieve the overexpression of HIF-1alpha and PD-L1 in tumor; meanwhile, it could react with H2O2 to release ROS via Fenton reaction and induce cytotoxicity in tumor.	ros	338-341	CD274 molecule	Homo sapiens	275-280
34854954-8	2022	Moreover, we found that ROS inhibition via NAC effectively blocks NLRP3 activation and pyroptosis.	ros	24-27	synuclein alpha	Homo sapiens	43-46
34964128-15	2021	Summarily, C3G exerted a protective effect on ROS-mediated cellular damage in HNPCs under HG condition, which was attributed to the induction of the Nrf2/HO-1 signaling pathway.	ros	46-49	heme oxygenase 1	Homo sapiens	154-158
34930286-8	2021	Besides, the Lipo-RSV could scavenge ROS and inhibit the NF-kappaB signal and inflammasomes, thereby reducing the pro-inflammatory cytokines IL-1beta, IL-6, and TNF-alpha.	ros	37-40	interleukin 1 alpha	Homo sapiens	141-149
34955649-14	2021	Furthermore, the increased levels of LDHA phosphorylation and the downstream NF-kappaB activation induced by LPS in epithelial cells were effectively diminished by OLFM4 overexpression and recombinant OLFM4 treatment via a reduction in ROS production and HIF1alpha expression.	ros	236-239	olfactomedin 4	Mus musculus	164-169
34955649-14	2021	Furthermore, the increased levels of LDHA phosphorylation and the downstream NF-kappaB activation induced by LPS in epithelial cells were effectively diminished by OLFM4 overexpression and recombinant OLFM4 treatment via a reduction in ROS production and HIF1alpha expression.	ros	236-239	olfactomedin 4	Mus musculus	201-206
34887359-13	2021	Silencing beta-catenin by sh-beta-catenin or XAV-939 exacerbated UVB irradiation-mediated cell senescence, apoptosis, and ROS production in HaCaT cells, which was ameliorated by Art treatment.	ros	122-125	catenin beta 1	Homo sapiens	10-22
34887359-13	2021	Silencing beta-catenin by sh-beta-catenin or XAV-939 exacerbated UVB irradiation-mediated cell senescence, apoptosis, and ROS production in HaCaT cells, which was ameliorated by Art treatment.	ros	122-125	catenin beta 1	Homo sapiens	29-41
34710368-0	2021	Tanshinone IIA derivatives induced S-phase arrest through stabilizing c-myc G-quadruplex DNA to regulate ROS-mediated PI3K/Akt/mTOR pathway.	ros	105-108	MYC proto-oncogene, bHLH transcription factor a	Danio rerio	70-75
34943041-6	2021	Furthermore, IL-10R neutralization as well as pharmacological treatment with the HO-1 inhibitor SnPP protected mice from parasite infection and allowed peritoneal APC to produce significantly higher ROS/RNS levels than those detected in cells from infected control mice.	ros	199-202	interleukin 10 receptor, alpha	Mus musculus	13-19
34656698-5	2021	Pharmacological inhibition of TrxR by EriB results in elevated ROS levels, reduced total GSH and thiols content, which ultimately induced potent RKO cell apoptosis mediated by oxidative stress.	ros	63-66	peroxiredoxin 5	Homo sapiens	30-34
34884817-0	2021	Transcriptomics Reveals the ERF2-bHLH2-CML5 Module Responses to H2S and ROS in Postharvest Calcium Deficiency Apples.	ros	72-75	ethylene-responsive transcription factor 2-like	Malus domestica	28-32
28411231-8	2017	In addition, ANG-(1-7) attenuated the ANG II-induced increase in mitochondrial ROS generation, an effect that was abolished by A779 or Sirt3 shRNA.	ros	79-82	sirtuin 3	Rattus norvegicus	135-140
28411231-10	2017	In summary, the protective effects of ANG-(1-7) on ANG II-induced cardiac hypertrophy and increased mitochondrial ROS production are mediated by elevated SOD2 expression via stimulation of Sirt3-dependent deacetylation of FoxO3a in cardiomyocytes.	ros	114-117	sirtuin 3	Rattus norvegicus	189-194
28411231-11	2017	Thus, activation of the ANG-(1-7)/Sirt3 signaling pathway could be a novel therapeutic strategy in the management of cardiac hypertrophy and associated complications.NEW &amp; NOTEWORTHY Chronic subcutaneous ANG-(1-7) has no effect on ANG II-induced elevations in blood pressure but significantly attenuates ANG II-induced cardiac hypertrophy and fibrosis by a mitochondrial ROS-dependent mechanism.	ros	375-378	sirtuin 3	Rattus norvegicus	34-39
28222464-6	2017	Treatment with TNF-alpha or ROS even decreased DPP-4 expression in mouse primary adipocytes.	ros	28-31	dipeptidylpeptidase 4	Mus musculus	47-52
28346230-5	2017	Glutaminase 1 (GLS1) inhibitors depleted pyrimidines and increased ROS in VHL-/- cells but not in VHL+/+ cells, which utilized glucose oxidation for glutamate and aspartate production.	ros	67-70	glutaminase	Homo sapiens	0-13
28346230-5	2017	Glutaminase 1 (GLS1) inhibitors depleted pyrimidines and increased ROS in VHL-/- cells but not in VHL+/+ cells, which utilized glucose oxidation for glutamate and aspartate production.	ros	67-70	glutaminase	Homo sapiens	15-19
28397803-8	2017	Mechanistically, tomatidine induces mitochondrial hormesis by mildly inducing ROS production, which in turn activates the SKN-1/Nrf2 pathway and possibly other cellular antioxidant response pathways, followed by increased mitophagy.	ros	78-81	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	122-127
28388692-5	2017	The further mechanisms of Compound 1-induced cellular apoptosis were confirmed that 1 induced the production of ROS and the alteration of pro- and anti-apoptotic proteins, which led to the dysfunction of mitochondria and activation of caspase-9 and caspase-3 and finally caused cellular apoptosis.	ros	112-115	caspase 9	Homo sapiens	235-244
28100784-6	2017	Using siRNA in HeLa cells, we found that reducing endogenous mOGT expression leads to alterations in mitochondrial structure and function, including Drp1-dependent mitochondrial fragmentation, reduction in mitochondrial membrane potential, and a significant loss of mitochondrial content in the absence of mitochondrial ROS.	ros	320-323	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	61-65
28094181-8	2017	Therefore, we assume that ROS generation is correlated with the increased NOX5 expression by FCPs.	ros	26-29	NADPH oxidase 5	Homo sapiens	74-78
28062686-7	2017	These observations could support the hypothesis that the GSTP1 G allele may improve exercise performance by better elimination of exercise-induced ROS.	ros	147-150	glutathione S-transferase pi 1	Homo sapiens	57-62
28225086-6	2017	UVRAG deficiency exacerbated DOX-induced mortality and cardiotoxicity manifested by increased cytoplasmic vacuolization, enhanced collagen accumulation, elevated serum activities of lactate dehydrogenase and myocardial muscle creatine kinase, higher ROS levels, aggravated apoptosis and more depressed cardiac function.	ros	250-253	UV radiation resistance associated gene	Mus musculus	0-5
28230797-7	2017	Importantly, ROS triggered MAPKs phosphorylation and P53 signaling mediated apoptosis were restored by ZYZ-772.	ros	13-16	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	53-56
28088327-8	2017	ROS levels were partially reduced by incubation with PP2 (c-Src inhibitor) or IL1RN, and further reduced by using the NOX1/4 inhibitor GKT137831.	ros	0-3	interleukin 1 receptor antagonist	Homo sapiens	78-83
28194433-3	2017	Mitochondria are an important source of cellular ROS production, and our group discovered that Ca2+/calmodulin-dependent protein kinase II (CaMKII) is present in mitochondria and activated by oxidation.	ros	49-52	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	95-138
28194433-3	2017	Mitochondria are an important source of cellular ROS production, and our group discovered that Ca2+/calmodulin-dependent protein kinase II (CaMKII) is present in mitochondria and activated by oxidation.	ros	49-52	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	140-146
28194433-8	2017	Mitochondrial ROS were decreased after agonist stimulation in the presence of mitochondrial CaMKII inhibition.	ros	14-17	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	92-98
28194433-10	2017	These findings demonstrate a pivotal role for mitochondrial CaMKII in airway epithelium in mitochondrial ROS generation, eosinophilic inflammation, and AHR, providing insights into how mitochondrial ROS mediate features of allergic asthma.	ros	105-108	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	60-66
28194433-10	2017	These findings demonstrate a pivotal role for mitochondrial CaMKII in airway epithelium in mitochondrial ROS generation, eosinophilic inflammation, and AHR, providing insights into how mitochondrial ROS mediate features of allergic asthma.	ros	199-202	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	60-66
28069379-5	2017	Moreover, NDRG2 overexpression aggravated energy imbalance and oxidative stress by decreasing the intracellular ATP and NADPH generation and increasing ROS levels.	ros	152-155	NDRG family member 2	Homo sapiens	10-15
28013460-0	2017	Arsenic trioxide induces ROS activity and DNA damage, leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway.	ros	25-28	ATM serine/threonine kinase	Homo sapiens	113-116
28013460-0	2017	Arsenic trioxide induces ROS activity and DNA damage, leading to G0/G1 extension in skin fibroblasts through the ATM-ATR-associated Chk pathway.	ros	25-28	choline kinase alpha	Homo sapiens	132-135
28011195-3	2017	In this study, using direct co-culture model with LPS-activated and Dox-induced senescent THP-1 monocytes, we reported for the first time ROS-induced DNA damage, reduced metabolic activity, proliferation inhibition and cell cycle arrest followed by p16-, p21- and p27-mediated DNA damage response pathways activation, premature senescence and apoptosis induction in HeLa cells.	ros	138-141	H3 histone pseudogene 16	Homo sapiens	255-258
28079897-6	2017	Indeed, Tsc1 promotes DC survival through restraining independent mTORC1 and ROS-Bim pathways.	ros	77-80	BCL2 like 11	Homo sapiens	81-84
34756890-8	2021	Additionally, GRP75 overexpression alone was sufficient to impair mitochondrial membrane potential, increase mitochondrial Ca2+ levels and ROS generation, augment ER-mitochondria contact, and induce apoptosis in these cells.	ros	139-142	heat shock protein 9	Mus musculus	14-19
29964052-9	2018	However, after ROS scavenger NAC was added to the cancer cells treated by resveratrol, DNMT1, DLC1 and senescence-associated molecular markers were reversed.	ros	15-18	synuclein alpha	Homo sapiens	29-32
34390123-6	2021	Combinational treatment of elesclomol and copper leads to copper retention within mitochondria due to ATP7A loss, leading to ROS accumulation, which in turn promotes the degradation of SLC7A11, thus further enhancing oxidative stress and consequent ferroptosis in CRC cells.	ros	125-128	solute carrier family 7 member 11	Homo sapiens	185-192
30217996-4	2018	Using PASK-deficient mice, we observed that PASK deficiency promotes antioxidant response mechanisms: a lower production of ROS/RNS under non-fasting conditions, overexpression of genes coding to ROS-detoxifying enzymes and mitochondrial fusion proteins (MnSod Gpx, Mfn1 and Opa1), coactivator Ppargc1a, transcription factors (Pparg and FoxO3a) and deacetylase Sirt1.	ros	124-127	PAS domain containing serine/threonine kinase	Mus musculus	44-48
34834129-0	2021	The Antileukemic Effect of Xestoquinone, A Marine-Derived Polycyclic Quinone-Type Metabolite, Is Mediated through ROS-Induced Inhibition of HSP-90.	ros	114-117	heat shock protein 90 alpha family class A member 1	Homo sapiens	140-146
34644617-10	2021	Altogether, deficiency of PDE4B inhibit the inflammasome activation and pyroptosis in LPS stimulated lung injury model and macrophages by regulating ROS/Nrf2/NLRP3 activation.	ros	149-152	NLR family, pyrin domain containing 3	Mus musculus	158-163
27888799-5	2017	The ROS scavenger NAC suppressed ROS generation and rescued cells from damage.	ros	4-7	synuclein alpha	Homo sapiens	18-21
27888799-5	2017	The ROS scavenger NAC suppressed ROS generation and rescued cells from damage.	ros	33-36	synuclein alpha	Homo sapiens	18-21
30217996-4	2018	Using PASK-deficient mice, we observed that PASK deficiency promotes antioxidant response mechanisms: a lower production of ROS/RNS under non-fasting conditions, overexpression of genes coding to ROS-detoxifying enzymes and mitochondrial fusion proteins (MnSod Gpx, Mfn1 and Opa1), coactivator Ppargc1a, transcription factors (Pparg and FoxO3a) and deacetylase Sirt1.	ros	196-199	PAS domain containing serine/threonine kinase	Mus musculus	44-48
29885837-7	2018	A 2.2-fold increase in the ROS level and an obvious increase in the cell apoptosis rate were observed in the si-TKTL1+paclitaxel group compared with those in the negative si-TKTL1+paclitaxel and OC3/Tax300 + paclitaxel groups.	ros	27-30	transketolase like 1	Homo sapiens	112-117
27792844-10	2017	The data suggest that the TRPA1 channels located on these capsaicin-sensitive afferent fibres are probable targets of ROS released during oxidative stress.	ros	118-121	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	26-31
28883885-6	2017	Cotreatment of NAC could partially reverse the ROS generation and ameliorate the cytotoxicity induced by BA plus Ptx.	ros	47-50	synuclein alpha	Homo sapiens	15-18
27913286-6	2017	Coumestrol treatment induced ROS generation coupled to DNA fragmentation, up-regulation of p53/p21, cell cycle arrest at G1/S phase, mitochondrial membrane depolarization and caspases 9/3 activation.	ros	29-32	H3 histone pseudogene 16	Homo sapiens	95-98
28751936-5	2017	MaR 1 significantly reduced ROS, methane dicarboxylic aldehyde, and 15-F2t-isoprostane generation and restored antioxidative enzyme (superoxide dismutase, glutathione peroxidase, and catalase) activities.	ros	28-31	retrotransposon Gag like 1	Homo sapiens	0-5
28751937-10	2017	Myricitrin attenuated the generation of intracellular ROS by inhibiting the assembly of components of the gp91phox and p47phox.	ros	54-57	neutrophil cytosolic factor 1	Mus musculus	119-126
28751937-11	2017	Suppression of ROS generation using NAC or apocynin or by silencing gp91phox and p47phox all demonstrated that decreasing the level of ROS inhibited the LPS-induced inflammatory response.	ros	135-138	neutrophil cytosolic factor 1	Mus musculus	81-88
28894505-5	2017	Furthermore, we found in MeCP2-deficient mouse (Mecp2-/y ) hippocampus an intensified mitochondrial metabolism and ROS generation.	ros	115-118	methyl CpG binding protein 2	Mus musculus	48-53
28042325-3	2017	In normal physiological conditions, the fluorescence and ROS generation ability of Ce6 are quenched by GNPs via RET; but in cancerous cells, the fluorescence and the ROS generation of Ce6 could be recovered by cleavage of Au-S bond through high level of intracellular GSH for real-time imaging and in demand PDT.	ros	57-60	ret proto-oncogene	Homo sapiens	112-115
28024356-4	2016	The focused ultrasound can activate H2O2 to generate more oxygen-contained species (ROS) of stronger oxidation ability than H2O2 for oxidizing LA via the energy transformation from ultrasound mechanical energy to chemical energy, and thus produce more NO for ultimately suppressing the highly aggressive and lethal Panc-1 tumor.	ros	84-87	pancreas protein 1	Mus musculus	315-321
27771433-8	2016	In the present work, we demonstrated that inhibition of ROS production by generating mitochondrial-electron-transport-deficient cell lines (rho0 cells) or by inhibition of NOX activity with a selective peptide inhibitor significantly reduced PP2A Tyr nitration and its activity in different cancer cell lines.	ros	56-59	protein phosphatase 2 phosphatase activator	Homo sapiens	242-246
27989748-6	2016	Furthermore, we demonstrated that NOX4-induced glycolysis probably via ROS/PI3K/Akt signaling-dependent c-Myc upregulation.	ros	71-74	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	104-109
27710854-5	2016	The antioxidant NAC is able to revert the cytotoxic effects, ROS generation and loss of mitochondrial membrane potential of MCF-7 cells treated with ABZ.	ros	61-64	synuclein alpha	Homo sapiens	16-19
27876813-0	2016	Oncogenic transformation of human lung bronchial epithelial cells induced by arsenic involves ROS-dependent activation of STAT3-miR-21-PDCD4 mechanism.	ros	94-97	microRNA 21	Homo sapiens	128-134
27561486-4	2016	The results indicated that pretreatment of PC12 cells with CPA-1 and CPB-2 significantly increased cell survival, Ca(2+) overload and ROS generation.	ros	134-137	carboxypeptidase B2	Rattus norvegicus	69-74
27659528-0	2016	Geridonin and paclitaxel act synergistically to inhibit the proliferation of gastric cancer cells through ROS-mediated regulation of the PTEN/PI3K/Akt pathway.	ros	106-109	phosphatase and tensin homolog	Homo sapiens	137-141
27782264-7	2016	Phase 2 enzymes in term of antioxidant response, such as heme oxygenase 1 (HMOX1) and the regulating subunit of the glutamate-cysteine ligase (GCLM) were slightly upregulated, but these observations may be linked solely to metal homeostasis disruptions, as these actors are involved in both metal and ROS responses.	ros	301-304	heme oxygenase 1	Homo sapiens	57-73
27782264-7	2016	Phase 2 enzymes in term of antioxidant response, such as heme oxygenase 1 (HMOX1) and the regulating subunit of the glutamate-cysteine ligase (GCLM) were slightly upregulated, but these observations may be linked solely to metal homeostasis disruptions, as these actors are involved in both metal and ROS responses.	ros	301-304	heme oxygenase 1	Homo sapiens	75-80
27806094-10	2016	Furthermore, a significant decrease in pAKT, pERK and p-p38 was shown following the addition of the ROS inhibitor NAC.	ros	100-103	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	45-49
27806094-10	2016	Furthermore, a significant decrease in pAKT, pERK and p-p38 was shown following the addition of the ROS inhibitor NAC.	ros	100-103	synuclein alpha	Homo sapiens	114-117
27619661-10	2016	Further, we noticed that, knockdown of cFLIPL and induced expression of FADD rapidly accumulate intracellular ROS accompanied by JNK1 activation to substantiate apoptosis.	ros	110-113	Fas associated via death domain	Homo sapiens	72-76
27655686-0	2016	Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism.	ros	83-86	transformation related protein 53, pseudogene	Mus musculus	10-13
27655686-4	2016	Here we showed that p53-null CLL cells were highly sensitive to ROS-mediated cell killing due to their intrinsic ROS stress.	ros	64-67	transformation related protein 53, pseudogene	Mus musculus	20-23
27655686-4	2016	Here we showed that p53-null CLL cells were highly sensitive to ROS-mediated cell killing due to their intrinsic ROS stress.	ros	113-116	transformation related protein 53, pseudogene	Mus musculus	20-23
27655686-11	2016	Our study identifies a vulnerability of p53-null CLL cells with high sensitivity to ROS-generating agents, and suggests that PEITC may potentially be useful for clinical treatment of CLL with 17p deletion and p53 mutations.	ros	84-87	transformation related protein 53, pseudogene	Mus musculus	40-43
27784668-8	2016	The conditioned media of the ROS 17/2.8 contained bone morphogenetic protein-2 (BMP-2 8.4 ng/mg, standard deviation (sd) 0.8) and BMP-7 (50.6 ng/mg, sd 2.2).	ros	29-32	bone morphogenetic protein 7	Rattus norvegicus	130-135
27401903-4	2016	We found that treatment with rapamycin, an mTOR-specific inhibitor, reduced intracellular ROS, maintained the mitochondrial membrane potential and restored mitochondrial dysfunction.	ros	90-93	mechanistic target of rapamycin kinase	Mus musculus	43-47
27669008-4	2016	In control BM (n = 24), ROS levels were highest in granulocyte-macrophage progenitors (GMP) and CD34- myeloid precursors but megakaryocyte-erythroid progenitors had equivalent levels to CD34+CD38low immature-SPC although they were ki67high.	ros	24-27	CD38 molecule	Homo sapiens	191-195
26404762-3	2016	Blocking HO-1 enzymatic activity by zinc protoporphyrin (ZnPP) augmented arsenic-induced apoptosis, ROS production and mitochondrial dysfunction, suggesting a critical role for HO-1 as a renal protectant in this procession.	ros	100-103	heme oxygenase 1	Homo sapiens	9-13
26404762-4	2016	On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression.	ros	68-71	heme oxygenase 1	Homo sapiens	36-40
26404762-4	2016	On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression.	ros	87-90	heme oxygenase 1	Homo sapiens	36-40
26404762-4	2016	On the other hand, TMP, upstream of HO-1, inhibited arsenic-induced ROS production and ROS-dependent HO-1 expression.	ros	87-90	heme oxygenase 1	Homo sapiens	101-105
26404762-6	2016	Our results revealed that the regulation of arsenic-induced HO-1 expression was performed through multiple ROS-dependent signal pathways and the corresponding transcription factors, including p38 MAPK and JNK (but not ERK), AP-1, Nrf2 and NF-kappaB.	ros	107-110	heme oxygenase 1	Homo sapiens	60-64
27539523-11	2016	It may be due to induce EBf-H9 cells to increase the production of ROS and to make the cells appear oxidative stress, which lead to oxidative damage to cells.	ros	67-70	EBF transcription factor 1	Homo sapiens	24-27
27368697-2	2016	Glutathione S-transferases (GSTs) are a family of antioxidant enzymes that play important roles in decreasing ROS species and act as a kind of antioxidant defense.	ros	110-113	glutathione S-transferase pi 1	Homo sapiens	28-32
27334614-7	2016	Interestingly, aging-induced Mfn2 deficiency triggers a ROS-dependent adaptive signaling pathway through induction of HIF1alpha transcription factor and BNIP3.	ros	56-59	hypoxia inducible factor 1, alpha subunit	Mus musculus	118-127
27422544-5	2016	When stress stimuli presents, SCO2 overexpresses and leads to ROS generation.	ros	62-65	synthesis of cytochrome C oxidase 2	Homo sapiens	30-34
27422544-6	2016	ROS promotes p53 inducing MALM (Mieap-induced accumulation of lysosome-like organelles within mitochondria) to repair dysfunctional mitochondria and MIV (Mieap-induced vacuole) to accomplish damaged mitochondria degradation.	ros	0-3	spermatogenesis associated 18	Homo sapiens	32-37
27422544-6	2016	ROS promotes p53 inducing MALM (Mieap-induced accumulation of lysosome-like organelles within mitochondria) to repair dysfunctional mitochondria and MIV (Mieap-induced vacuole) to accomplish damaged mitochondria degradation.	ros	0-3	spermatogenesis associated 18	Homo sapiens	154-159
27406999-2	2016	Consequent CYP2E1 gain of function accelerates reactive O2 species (ROS) production, triggering oxidative/proteotoxic stress associated with sustained activation of c-Jun NH2-terminal kinase (JNK)-signaling cascades, pro-inflammatory effectors/cytokines, insulin resistance, progressive hepatocellular ballooning and microvesicular steatosis.	ros	68-71	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	11-17
27368608-13	2016	Increased expression of aldo-keto reductase family 1, member C1 and C3 suggests enhanced sterol metabolism and increased ROS-mediated lipid peroxidation.	ros	121-124	aldo-keto reductase family 1 member C1	Homo sapiens	24-63
27166596-0	2016	Corrigendum to "Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1-AMPK-mTOR pathway" [Atherosclerosis 243 (1) (2015) 223-235].	ros	68-71	serine/threonine kinase 11	Homo sapiens	89-93
27279909-10	2016	Taken together, our data suggest that a GSH-mediated reduction in cellular ROS levels is an essential regulator of CRC SP cells mediated by the CD44v-xCT axis, and disrupting the redox status may eliminate the chemotherapy-resistant CRC SP cells with potentially significant benefits for cancer treatment.	ros	75-78	solute carrier family 7 member 11	Homo sapiens	150-153
26942697-0	2016	Repeated PM2.5 exposure inhibits BEAS-2B cell P53 expression through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation.	ros	69-72	DNA methyltransferase 3 beta	Homo sapiens	77-83
26942697-7	2016	Furthermore, ROS-induced activation of Akt was involved in PM2.5-induced increase in DNMT3B.	ros	13-16	DNA methyltransferase 3 beta	Homo sapiens	85-91
26942697-8	2016	In conclusion, our results strongly suggest that repeated exposure to PM2.5 induces epigenetic silencing of P53 through ROS-Akt-DNMT3B pathway-mediated promoter hypermethylation, which not only provides a possible explanation for PM-induced lung cancer, but also may help to identify specific interventions to prevent PM-induced lung carcinogenesis.	ros	120-123	DNA methyltransferase 3 beta	Homo sapiens	128-134
26974211-3	2016	Increased intracellular ROS was observed when SIRT1, 2, 3 activity was inhibited.	ros	24-27	sirtuin 1	Mus musculus	46-51
26974211-6	2016	The results suggest that the SIRT1, 2, 3 pathway may play a potential protective role against postovulatory oocyte aging by controlling ROS generation.	ros	136-139	sirtuin 1	Mus musculus	29-34
26874430-11	2016	Inhibition of ceramide synthesis with FB1 and ROS production with n-MPG scavenging rescued MMP activity and IL-1beta production in palmitate treated heterophils, but exacerbated monocyte suppression.	ros	46-49	interleukin 1, beta	Gallus gallus	108-116
27029354-6	2016	In particular, the phosphorylation of MPK6, which is involved in regulating ROS responses under abiotic stresses, was disrupted in the SnRK1.1 (K48M) mutant.	ros	76-79	SNF1 kinase homolog 10	Arabidopsis thaliana	135-142
26573462-4	2016	RESULTS: We found that monocyte chemoattractant protein-1 (MCP-1) was secreted as a dominant component of the SASP during expansion of UCB-MSCs and reinforced senescence via its cognate receptor chemokine (c-c motif) receptor 2 (CCR2) by activating the ROS-p38-MAPK-p53/p21 signaling cascade in both an autocrine and paracrine manner.	ros	253-256	C-C motif chemokine ligand 2	Homo sapiens	23-57
26573462-4	2016	RESULTS: We found that monocyte chemoattractant protein-1 (MCP-1) was secreted as a dominant component of the SASP during expansion of UCB-MSCs and reinforced senescence via its cognate receptor chemokine (c-c motif) receptor 2 (CCR2) by activating the ROS-p38-MAPK-p53/p21 signaling cascade in both an autocrine and paracrine manner.	ros	253-256	C-C motif chemokine ligand 2	Homo sapiens	59-64
26775282-5	2016	The mechanism studies revealed that complexes can induce apoptosis in HepG2 cells by generating ROS metabolites, triggering mitochondrial membrane potential loss and down-regulation of P-Akt (Akt also known as protein kinase B), P-p44/42 MAP kinase protein (P-p44/42), and c-MYC.	ros	96-99	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	273-278
26653078-2	2016	By being conjugated with a triphenylphosphine (TPP) motif to a previously found TrxR inhibitor 2a, the resulted compound TPP2a can target subcellular mitochondria and efficiently inhibit cellular TrxR, leading to remarkably increased cellular ROS level and mitochondrial apoptosis of HeLa cancer cells.	ros	243-246	peroxiredoxin 5	Homo sapiens	80-84
26653078-2	2016	By being conjugated with a triphenylphosphine (TPP) motif to a previously found TrxR inhibitor 2a, the resulted compound TPP2a can target subcellular mitochondria and efficiently inhibit cellular TrxR, leading to remarkably increased cellular ROS level and mitochondrial apoptosis of HeLa cancer cells.	ros	243-246	peroxiredoxin 5	Homo sapiens	196-200
26848751-8	2016	However, pre-treatment with antioxidants, NVN and NAC, which suppressed ROS generation, did not reduce IL-8 expression in IL-1beta-treated orbital fibroblasts, suggesting that the IL-1beta-induced IL-8 expression is not mediated by the generation of ROS.	ros	72-75	synuclein alpha	Homo sapiens	50-53
27144424-5	2016	In vitro, the IGF-1 level in the hepatocyte supernatant was enhanced by melatonin with lower p-JAK2/p-STAT3 and ROS levels, which was suppressed by Mel1c antagonist but not Mel1a/Mel1b or Mel1b antagonists.	ros	112-115	insulin like growth factor 1	Gallus gallus	14-19
27144424-5	2016	In vitro, the IGF-1 level in the hepatocyte supernatant was enhanced by melatonin with lower p-JAK2/p-STAT3 and ROS levels, which was suppressed by Mel1c antagonist but not Mel1a/Mel1b or Mel1b antagonists.	ros	112-115	G protein-coupled receptor 50	Gallus gallus	148-153
34808241-5	2022	The altered UV response was linked to elevated intracellular calcium levels and ROS, and this was due to dysregulation of the ER calcium channel inositol triphosphate receptor (InsP3R).	ros	80-83	inositol 1,4,5-trisphosphate receptor 1	Mus musculus	177-183
34840668-0	2021	CaMK II Inhibition Attenuates ROS Dependent Necroptosis in Acinar Cells and Protects against Acute Pancreatitis in Mice.	ros	30-33	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	0-7
34775471-5	2021	Besides, levels of ROS and MDA were increased upon SREBP1 inhibition and even more upon gefitinib treatment.	ros	19-22	sterol regulatory element binding transcription factor 1	Homo sapiens	51-57
34753356-6	2021	The potential neuroprotective effect of PaT-2 was further corroborated in FRET-based live cell imaging assays, where the peptide prevented lipopolysaccharide-induced ROS production and glutamate release in human microglia.	ros	166-169	solute carrier family 36 member 2	Homo sapiens	40-45
34743782-11	2022	Remarkably, TCCM from 4T1-NDRG2 cells reduced the expression of PD-L1 and Fra-1 as well as the production of GM-CSF, IL-10 and ROS, leading to the attenuation of T cellinhibitory activity of PEM.	ros	127-130	N-myc downstream regulated gene 2	Mus musculus	26-31
34509082-6	2021	Furthermore, cellular total ROS and mitochondrial ROS generation, and impairment of mitochondrial membrane potential (MMP) were highly induced by ox-LDL in THP1 cells, while being considerably reversed upon CISD1 over-expression.	ros	28-31	CDGSH iron sulfur domain 1	Homo sapiens	207-212
34509082-6	2021	Furthermore, cellular total ROS and mitochondrial ROS generation, and impairment of mitochondrial membrane potential (MMP) were highly induced by ox-LDL in THP1 cells, while being considerably reversed upon CISD1 over-expression.	ros	50-53	CDGSH iron sulfur domain 1	Homo sapiens	207-212
34831264-3	2021	We hypothesized, that the improved tolerance to oxidative stress will increase the ability of cancer cells to cope with ROS-induced damage to free deoxy-nucleotides (dNTPs) required for DNA replication and may thus contribute to acquired resistance of cancer cells in advanced tumors to antineoplastic agents inhibiting the nucleotide-sanitizing enzyme MutT Homologue-1 (MTH1), ionizing radiation (IR) or both.	ros	120-123	nudix hydrolase 1	Homo sapiens	353-369
34831264-3	2021	We hypothesized, that the improved tolerance to oxidative stress will increase the ability of cancer cells to cope with ROS-induced damage to free deoxy-nucleotides (dNTPs) required for DNA replication and may thus contribute to acquired resistance of cancer cells in advanced tumors to antineoplastic agents inhibiting the nucleotide-sanitizing enzyme MutT Homologue-1 (MTH1), ionizing radiation (IR) or both.	ros	120-123	nudix hydrolase 1	Homo sapiens	371-375
34739306-5	2022	Simultaneously, they can reset the levels of pro-apoptotic proteins that belong to the Bcl-2 and caspase family and decrease the intracellular levels of ROS and pro-inflammatory cytokines, such as TNF-alpha, IL-1beta and IL-6.	ros	153-156	interleukin 1 alpha	Homo sapiens	208-216
34697618-6	2021	This O2 can not only further improve the catalytic efficiency of GOX, but also provide raw materials for the production of ROS in PDT, which can effectively destroy the mitochondria of cancer cells, thereby causing tumor cell apoptosis.	ros	123-126	hydroxyacid oxidase 1, liver	Mus musculus	65-68
34562843-0	2021	Epigallocatechin gallate (EGCG) attenuates staphylococcal alpha-hemolysin (Hla)-induced NLRP3 inflammasome activation via ROS-MAPK pathways and EGCG-Hla interactions.	ros	122-125	NLR family, pyrin domain containing 3	Mus musculus	88-93
34562843-9	2021	Collectively, EGCG could be a promising candidate for alleviating Hla-induced the activation of NLRP3 inflammasome, depending on ROS mediated MAPK signaling pathway, and inhibition of Hla secretion and heptamer formation.	ros	129-132	NLR family, pyrin domain containing 3	Mus musculus	96-101
34716298-4	2021	Meanwhile, telomerase reverse transcriptase (TERT), the catalytic portion of the telomerase protein, is reported to travel to the mitochondria to alleviate ROS.	ros	156-159	telomerase reverse transcriptase	Mus musculus	11-43
34716298-4	2021	Meanwhile, telomerase reverse transcriptase (TERT), the catalytic portion of the telomerase protein, is reported to travel to the mitochondria to alleviate ROS.	ros	156-159	telomerase reverse transcriptase	Mus musculus	45-49
34832853-6	2021	Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA-AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFkappaB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells.	ros	60-63	matrix metallopeptidase 1	Homo sapiens	266-271
34737695-12	2021	Collectively, the inhibition of mitochondrial ROS-mediated NLRP3 inflammasome activation contributes to the protective effects of CA, which may be considered a potential therapeutic agent for septic ALI.	ros	46-49	NLR family, pyrin domain containing 3	Mus musculus	59-64
34486148-1	2021	MPZL3 is a nuclear-encoded, mitochondrially localized, immunoglobulin-like V-type protein that functions as a key regulator of epithelial cell differentiation, lipid metabolism, ROS production, glycemic control, and energy expenditure.	ros	178-181	myelin protein zero like 3	Homo sapiens	0-5
34363947-4	2021	Cytokine (a mixture of IL-1beta, TNF-alpha, and IFN-gamma) treated AQP8 KD cells exhibited pronounced sensitivity to reactive oxygen and nitrogen species (ROS and RNS), resulting in a significant loss of beta-cell viability due to enhanced toxicity of the increased concentrations of H2O2 and hydroxyl radicals ( OH) in mitochondria of AQP8 KD cells.	ros	155-158	interferon gamma	Rattus norvegicus	48-57
34333354-9	2021	Subsequently, TSG promoted the activation of GSH/GPX4/ROS and Keap1/Nrf2/ARE signaling pathways.	ros	54-57	glutathione peroxidase 4	Mus musculus	49-53
34293554-5	2021	In cells cultured in the absence of glucose, knockout of IDH1 and ME1 decreases NADPH/NADP+ and GSH/GSSG, increases ROS level and facilitates cell necrosis.	ros	116-119	isocitrate dehydrogenase 1 (NADP+), soluble	Mus musculus	57-61
34584017-10	2021	On the other hand, the down-regulation of GPR43 promoted inflammatory reactions in vitro model through the acceleration of ROS-dependently mitochondrial damage by PPARgamma/ Nox1/EBP50/ p47phox/ NLRP3 signal channel.	ros	123-126	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	179-184
34584017-10	2021	On the other hand, the down-regulation of GPR43 promoted inflammatory reactions in vitro model through the acceleration of ROS-dependently mitochondrial damage by PPARgamma/ Nox1/EBP50/ p47phox/ NLRP3 signal channel.	ros	123-126	neutrophil cytosolic factor 1	Mus musculus	186-193
34584017-10	2021	On the other hand, the down-regulation of GPR43 promoted inflammatory reactions in vitro model through the acceleration of ROS-dependently mitochondrial damage by PPARgamma/ Nox1/EBP50/ p47phox/ NLRP3 signal channel.	ros	123-126	NLR family, pyrin domain containing 3	Mus musculus	195-200
34659883-10	2021	The suppression of tNOX and SIRT1 then enhanced ULK1 acetylation and induced ROS-dependent autophagy in melanoma cells.	ros	77-80	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	19-23
34659883-10	2021	The suppression of tNOX and SIRT1 then enhanced ULK1 acetylation and induced ROS-dependent autophagy in melanoma cells.	ros	77-80	sirtuin 1	Mus musculus	28-33
34659883-12	2021	Taken together, our findings suggest that tNOX expression is important for the growth of melanoma cancer cells both in vitro and in vivo, and that inhibition of the tNOX-SIRT1 axis contributes to inducting ROS-dependent autophagy in melanoma cells.	ros	206-209	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	42-46
34659883-12	2021	Taken together, our findings suggest that tNOX expression is important for the growth of melanoma cancer cells both in vitro and in vivo, and that inhibition of the tNOX-SIRT1 axis contributes to inducting ROS-dependent autophagy in melanoma cells.	ros	206-209	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	165-169
34659883-12	2021	Taken together, our findings suggest that tNOX expression is important for the growth of melanoma cancer cells both in vitro and in vivo, and that inhibition of the tNOX-SIRT1 axis contributes to inducting ROS-dependent autophagy in melanoma cells.	ros	206-209	sirtuin 1	Mus musculus	170-175
34575486-8	2021	Mechanistically, finasteride lowered intracellular ROS level by upregulating antioxidant genes, which contributed to inefficient beta-catenin accumulation.	ros	51-54	catenin beta 1	Homo sapiens	129-141
34298092-8	2021	Co-culture with CHIP-expressing WJMSCs maintained HK-2 cell viability, and inhibited apoptosis and fibrosis by attenuating HG-induced ROS-mediated MAPK activation.	ros	134-137	STIP1 homology and U-box containing protein 1	Rattus norvegicus	16-20
34157442-11	2021	Inhibition of mTORC1 led to the downregulation of GPX4 which promoted Lap induced ferroptosis as evidenced by increase of ROS, MDA, Fe 2+ and decrease of GSH.	ros	122-125	glutathione peroxidase 4	Mus musculus	50-54
34217685-5	2021	Furthermore, it was demonstrated that luteolin promoted Nrf2 nuclear translocation, thereby increasing the expression of HO-1 that reduces ROS production, while the anti-pyroptotic effect of luteolin was reversed by a specific Nrf2 inhibitor.	ros	139-142	heme oxygenase 1	Homo sapiens	121-125
34097996-5	2021	Further investigation revealed that PFBL mediates its function through upregulating ROS production by enhanced catalytic activity of monoamine oxidase A (MAO-A).	ros	84-87	monoamine oxidase A	Homo sapiens	133-152
34097996-5	2021	Further investigation revealed that PFBL mediates its function through upregulating ROS production by enhanced catalytic activity of monoamine oxidase A (MAO-A).	ros	84-87	monoamine oxidase A	Homo sapiens	154-159
34439556-8	2021	In EC, BGP increased Nox4 expression and ROS production, which reduced NOS3 expression via NFkappaB.	ros	41-44	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	7-10
34439556-10	2021	In SMC, BGP increased Collagen I and fibronectin expression by priming ROS production and NFkappaB activity.	ros	71-74	carcinoembryonic antigen-related cell adhesion molecule 1	Mus musculus	8-11
34439556-10	2021	In SMC, BGP increased Collagen I and fibronectin expression by priming ROS production and NFkappaB activity.	ros	71-74	fibronectin 1	Mus musculus	37-48
34407394-1	2021	In Caenorhabditis elegans, ROS generated in response to intestinal infection induces SKN-1, a protective transcription factor homologous to nuclear factor erythroid 2-related factor 1 or 2 (NRF1/2) in mammals.	ros	27-30	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	85-90
34400737-7	2021	Thus, this study indicated that VVPF had an alleviative effect on CCl4-induced necroinflammation and oxidative stress in rat kidney, lung, brain, and spleen via controlling the ROS/NF-kappaB pathway.	ros	177-180	C-C motif chemokine ligand 4	Homo sapiens	66-70
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	ros	2-5	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-3	2022	A ROS-activatable prodrug BH-EGCG is synthesized by coupling a near-infrared chromophore with the NF-kappaB/NLRP3 inhibitor epigallocatechin-3-gallate (EGCG) through boronate bond which serves as both the fluorescence quencher and ROS-responsive moiety.	ros	231-234	NLR family, pyrin domain containing 3	Mus musculus	108-113
34901531-6	2022	Benefiting from the inflammation-homing effect of the macrophage membrane, the nanosystem delivers payloads (diagnostic probe and therapeutic drugs) to inflammatory lesions more efficiently and releases a chromophore and two drugs upon being triggered by the overexpressed in-situ ROS, thus exhibiting better theranostic performance in the autoimmune hepatitis and hind paw edema mouse models, including more salient imaging signals and better therapeutic efficacy via inhibiting NF-kappaB pathway and suppressing NLRP3 inflammasome activation.	ros	281-284	NLR family, pyrin domain containing 3	Mus musculus	514-519
34111283-4	2021	Reactive oxygen and nitrogen species (ROS/RNS), as well as redox signals, are key molecules involved at the crossroads of perceptions of different stress factors and regulation of both specific and general plant responses to biotic and abiotic stress.	ros	38-41	FAM20C golgi associated secretory pathway kinase	Homo sapiens	42-45
34118452-4	2021	Accumulation of damaged ROS-generating mitochondria, accompanied by the release of mitochondrial DAMPs, can activate PRRs such as the NLRP3 inflammasome, TLR9, cGAS/STING, and ZBP1.	ros	24-27	cyclic GMP-AMP synthase	Homo sapiens	160-164
34112953-0	2021	Correction: IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.	ros	85-88	IQ motif containing GTPase activating protein 1	Homo sapiens	12-18
34439436-5	2021	By comparing an antioxidant (Q-ter) and an anti-inflammatory (Anakinra) treatment, we demonstrated that oxidative stress is the primary element of damage in noise-induced cochlear injury and that increased inflammation can be considered a consequence of PPAR down-regulation induced by ROS production.	ros	286-289	peroxisome proliferator activated receptor alpha	Homo sapiens	254-258
34137412-9	2021	The synergistic effect jointly caused a burst generation of mitochondrial ROS, which significantly down-regulated Bcl-2 protein expression, accelerated cytochrome c release and triggered a cascade of apoptosis-related proteins of Caspase-3 and Caspase-9.	ros	74-77	caspase 9	Homo sapiens	244-253
34099889-5	2021	Continuous activation of SR-E1+ PMN-MDSCs was observed in all stages of pregnancy, accompanied by high cellular levels of ROS and arginase-1 activity, mediated through STAT6 signaling.	ros	122-125	signal transducer and activator of transcription 6	Homo sapiens	168-173
34207085-4	2021	As the generation of mitochondrial reactive oxidative species (ROS) is a critical upstream event in the activation of NLRP3, we investigated whether anakinra would regulate mitochondrial ROS production.	ros	63-66	NLR family, pyrin domain containing 3	Mus musculus	118-123
34132394-0	2022	Piceatannol alleviate ROS-mediated PC-12 cells damage and mitochondrial dysfunction through SIRT3/FOXO3a signaling pathway.	ros	22-25	sirtuin 3	Rattus norvegicus	92-97
34203664-9	2021	Here, we show that Flt3-ITD+ cells are sensitive to an IB-induced dynamin 1-like (Drp1)-p38-ROS pathway.	ros	92-95	dynamin 1 like	Homo sapiens	82-86
34128473-5	2021	Stable ACC1 protein expression suppressed the growth-promoting activity and increased ROS levels with the consumption of NADPH in a primary bone marrow culture, and delayed the onset of AML with increases in mature myeloid cells in mouse models.	ros	86-89	acetyl-Coenzyme A carboxylase alpha	Mus musculus	7-11
34060394-5	2022	Moreover, this agent induced ROS-mediated apoptosis by altering the expression of Bax, Bim, Caspase3, Bcl2, and XIAP.	ros	29-32	BCL2 like 11	Homo sapiens	87-90
34093596-4	2021	PARK7 decreased markedly in atrophic kidney tubules in UUO mice, and Park7 deficiency aggravated UUO-induced renal fibrosis, tubular cell apoptosis, ROS production and inflammation.	ros	149-152	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	0-5
34093596-4	2021	PARK7 decreased markedly in atrophic kidney tubules in UUO mice, and Park7 deficiency aggravated UUO-induced renal fibrosis, tubular cell apoptosis, ROS production and inflammation.	ros	149-152	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	69-74
34093596-6	2021	Park7 knockdown exacerbated TGFB1-induced fibrotic changes, cell apoptosis and ROS production, whereas Park7 overexpression or treatment with ND-13 (a PARK7-derived peptide) attenuated these TGFB1-induced changes.	ros	79-82	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	0-5
34249264-1	2021	Objectives: Sirt3 may regulate ROS production and might be involved in beta-cell apoptosis, which plays an important role in the progression of type 2 diabetes mellitus (T2DM).	ros	31-34	sirtuin 3	Rattus norvegicus	12-17
35526619-0	2022	Silica nanoparticles induce cardiac injury and dysfunction via ROS/Ca2+/CaMKII signaling.	ros	63-66	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	72-78
35636017-5	2022	Further results demonstrated that CPX could induce cytoprotective autophagy by downregulating the expression of PARK7 to activate PRKAA1 or by PARK7-independent accumulation of ROS to inhibit mTOR signaling.	ros	177-180	Parkinsonism associated deglycase	Homo sapiens	143-148
35337516-6	2022	Besides, ARP-1 decreased the production of ROS and MDA, and improved the activities of SOD, which resulted in the protection of PC12 cells against H2O2-induced oxidative stress.	ros	43-46	nuclear receptor subfamily 2, group F, member 2	Rattus norvegicus	9-14
35367826-14	2022	Knockdown of Piezo1 in P5 chondrocytes reduced Ca2+ and ROS concentrations, promoted the proliferation and reduced the proportion of senescent cells and the expression of SASP-related genes.	ros	56-59	piezo-type mechanosensitive ion channel component 1	Mus musculus	13-19
35367826-15	2022	Activation of Piezo1 in chondrocytes by Yoda1 inhibited the proliferation, promoted senescence and SASP, and increased the concentration of cellular Ca2+ and ROS, but BAPTA-AM intervention reversed these phenomena.	ros	158-161	piezo-type mechanosensitive ion channel component 1	Mus musculus	14-20
35367811-6	2022	XBP1 deficiency increased ROS production to promote hepatocellular pyroptosis by activating NLRP3/caspase-1/GSDMD signaling, which facilitated the extracellular release of mtDNA.	ros	26-29	NLR family, pyrin domain containing 3	Mus musculus	92-97
35624400-8	2022	RESULTS: TRX may play a role in OSAHS by scavenging ROS, blocking the production of inflammatory cytokines, inhibiting the migration and activation of neutrophils, and controlling the activation of ROS-dependent inflammatory signals by regulating the redox state of intracellular target particles.	ros	52-55	thioredoxin	Homo sapiens	9-12
35616096-4	2022	CPT MV could produce ROS in the targeted cells upon laser irradiation to improve death receptor (DR)-5 expression and trigger Cyt c release from mitochondria.	ros	21-24	TNF receptor superfamily member 10b	Homo sapiens	81-102
35599281-8	2022	Notably, pre-treatment of NAC, a ROS scavenger, reversed apoptosis induced by combined treatment of AP and cisplatin, while relieving the activation of endoplasmic reticulum stress as well as STAT3 inhibition.	ros	33-36	synuclein alpha	Homo sapiens	26-29
30125721-6	2018	The mechanism studies indicated the mitochondrial localization of BODIPY3-PEG3 was able to generate ROS in mitochondria, which further result in mitochondrial dysfunction and photoinduced apoptosis via caspase-8 and caspase-3 pathway.	ros	100-103	paternally expressed 3	Homo sapiens	74-78
29671417-7	2018	These results demonstrate that TLR4 is a primary receptor in SK-N-SH cells, by which Abeta25-35 triggers neuroinflammation, and cyanidin attenuates Abeta-induced inflammation and ROS production mediated by the TLR4/NOX4 pathway, suggesting that inhibition of TLR4 by cyanidin could be beneficial in preventing neuronal cell death in the process of Alzheimer"s disease.	ros	179-182	toll like receptor 4	Homo sapiens	210-214
35613681-2	2022	The current work aims to explore the roles of ROS-promoted AKAP1 degradation and excessive mitochondrial fission in 1-NP-induced steroidogenesis disruption in MLTC-1 cells.	ros	46-49	A kinase (PRKA) anchor protein 1	Mus musculus	59-64
35613681-12	2022	The present study indicates that ROS mediated AKAP1 degradation and subsequent pDRP1 (Ser637) dependent mitochondrial fission is indispensable in 1-NP caused T synthesis disruption.	ros	33-36	A kinase (PRKA) anchor protein 1	Mus musculus	46-51
35381197-6	2022	Functionally, filamentous GLS1-dependent glutamine scarcity leads to inadequate synthesis of asparagine and mitogenome-encoded proteins, resulting in ROS-induced apoptosis that can be rescued by asparagine supplementation.	ros	150-153	glutaminase	Homo sapiens	26-30
35594840-2	2022	Here, we talk to first author Bin Jiang and group leader Qinxi Li about their paper, "Filamentous GLS1 promotes ROS-induced apoptosis upon glutamine deprivation via insufficient asparagine synthesis," and Qinxi tells us about his lab"s research and perseverance during lockdowns.	ros	112-115	glutaminase	Homo sapiens	98-102
35628508-0	2022	An Experimental Study Reveals the Protective Effect of Autophagy against Realgar-Induced Liver Injury via Suppressing ROS-Mediated NLRP3 Inflammasome Pathway.	ros	118-121	NLR family, pyrin domain containing 3	Mus musculus	131-136
35628508-8	2022	Furthermore, we found that realgar-induced NLRP3 inflammasome activation in mouse livers is mediated by ROS.	ros	104-107	NLR family, pyrin domain containing 3	Mus musculus	43-48
35628508-9	2022	RAPA eliminates excessive ROS, inhibits NF-kappaB nuclear translocation and down-regulates the TXNIP/NLRP3 axis, consequently suppressing ROS-mediated NLRP3 inflammasome activation, which may be the underlying mechanism of the protective effect of autophagy on realgar-induced liver injury.	ros	138-141	NLR family, pyrin domain containing 3	Mus musculus	101-106
35628508-9	2022	RAPA eliminates excessive ROS, inhibits NF-kappaB nuclear translocation and down-regulates the TXNIP/NLRP3 axis, consequently suppressing ROS-mediated NLRP3 inflammasome activation, which may be the underlying mechanism of the protective effect of autophagy on realgar-induced liver injury.	ros	138-141	NLR family, pyrin domain containing 3	Mus musculus	151-156
35628508-10	2022	In conclusion, the results of this study suggest that autophagy alleviates realgar-induced liver injury by inhibiting ROS-mediated NLRP3 inflammasome activation.	ros	118-121	NLR family, pyrin domain containing 3	Mus musculus	131-136
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	ros	171-174	catenin beta 1	Homo sapiens	111-123
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	ros	171-174	solute carrier family 7 member 11	Homo sapiens	129-136
35562334-5	2022	Notably, suppression of FGFR4 dramatically diminishes glutathione synthesis and Fe2+ efflux efficiency via the beta-catenin/TCF4-SLC7A11/FPN1 axis, resulting in excessive ROS production and labile iron pool accumulation.	ros	171-174	solute carrier family 40 member 1	Homo sapiens	137-141
35594653-4	2022	Mechanistic investigations showed that compound a21-2 induces ROS production, which subsequently causes DNA damage and activation of ATM/Chk2, leading to G2/M phase arrest.	ros	62-65	ATM serine/threonine kinase	Homo sapiens	133-136
35247918-2	2022	Herein, we explored the therapeutic potential to enhance chemotherapy response in AML, by targeting the ROS scavenger enzyme MutT homolog 1 (MTH1, NUDT1), which protects cellular integrity through prevention of fatal chemotherapy-induced oxidative DNA damage.	ros	104-107	nudix hydrolase 1	Homo sapiens	147-152
35247918-4	2022	Strikingly, combinatorial treatment of inv(16)/KITD816Y AML cells with the MTH1 inhibitor TH1579 and ROS- and DNA damage-inducing standard chemotherapy induced growth arrest and incorporated oxidized nucleotides into DNA leading to significantly increased DNA damage.	ros	101-104	nudix hydrolase 1	Homo sapiens	75-79
35104550-4	2022	Moreover, the same treatment showed a marked upregulation in enzymes activity (APX, SOD, APX, and CAT) which oxidized the cell-damaging ROS, produced in response to As stress.	ros	136-139	ascorbate peroxidase 2	Zea mays	79-82
35104550-4	2022	Moreover, the same treatment showed a marked upregulation in enzymes activity (APX, SOD, APX, and CAT) which oxidized the cell-damaging ROS, produced in response to As stress.	ros	136-139	ascorbate peroxidase 2	Zea mays	89-92
35099110-0	2022	2,4-dichlorophenoxyacetic acid induces ROS activation in NLRP3 inflammatory body-induced autophagy disorder in microglia and the protective effect of Lycium barbarum polysaccharide.	ros	39-42	NLR family, pyrin domain containing 3	Mus musculus	57-62
35180474-3	2022	Electrophysiological studies on VDAC3 carrying selective cysteine mutations and mass spectrometry data about the redox state of such sulfur containing amino acids are consistent with a putative involvement of isoform 3 in mitochondrial ROS homeostasis.	ros	236-239	voltage dependent anion channel 3	Homo sapiens	32-37
35562931-7	2022	Further ROS scavenging by GSH application or ROS synthesis inhibition by apocynin application or RBOHD mutation reduced H2O2 levels and partially restored the root-growth arrest phenotype of shm1-2 at low-sucrose conditions, suggesting that SHMT1 modulates root growth via sucrose-mediated ROS accumulation.	ros	8-11	serine hydroxymethyltransferase 1	Homo sapiens	241-246
35562931-8	2022	Our findings demonstrated the role of SHMT1 in primary-root growth by regulating sucrose accumulation and ROS homeostasis in roots.	ros	106-109	serine hydroxymethyltransferase 1	Homo sapiens	38-43
35389129-8	2022	As a result, the inhibited myocardial autophagic flux induced by TRPML1 disrupted mitochondria turnover and resulted in mass accumulation of damaged mitochondria and further ROS release, which directly led to cardiomyocyte death.	ros	174-177	mucolipin 1	Mus musculus	65-71
35389129-10	2022	In summary, our study demonstrates that secondary to ROS elevation, activation of TRPML1 results in autophagy inhibition in the cardiomyocytes subjected to I/R, which directly leads to cardiomyocyte death by disrupting mitochondria turnover.	ros	53-56	mucolipin 1	Mus musculus	82-88
35464414-10	2022	To sum up, macrophage pyroptosis is an upstream event of silica-induced pulmonary inflammation promoted by ROS through the TLR4/NLRP3/NF-kappaB signaling axis.	ros	107-110	NLR family, pyrin domain containing 3	Mus musculus	128-133
35366902-0	2022	A synthesized olean-28,13beta-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma.	ros	72-75	YTH N6-methyladenosine RNA binding protein 1	Homo sapiens	45-51
35366902-0	2022	A synthesized olean-28,13beta-lactam targets YTHDF1-GLS1 axis to induce ROS-dependent metabolic crisis and cell death in pancreatic adenocarcinoma.	ros	72-75	glutaminase	Homo sapiens	52-56
35366902-13	2022	We further validated that cell cycle arrest, inhibition of cell growth, cell apoptosis and cell bioenergetics disruption were functionally rescued by ROS scavenger NAC.	ros	150-153	synuclein alpha	Homo sapiens	164-167
26726832-2	2016	Intriguingly, fortilin protects cells against ROS-induced cell death, independent of p53.	ros	46-49	tumor protein, translationally-controlled 1	Mus musculus	14-22
26726832-3	2016	The signaling pathway through which fortilin protects cells against ROS-induced cell death, however, is unknown.	ros	68-71	tumor protein, translationally-controlled 1	Mus musculus	36-44
26726832-5	2016	At the whole animal level, the liver-specific overexpression of fortilin reduced PRX1 phosphorylation in the liver, enhanced PRX1 activity, and protected the transgenic animals against alcohol-induced, ROS-mediated, liver damage.	ros	202-205	tumor protein, translationally-controlled 1	Mus musculus	64-72
27119348-0	2016	Gambogic Acid Inhibits Malignant Melanoma Cell Proliferation Through Mitochondrial p66shc/ROS-p53/Bax-Mediated Apoptosis.	ros	90-93	transformation related protein 53, pseudogene	Mus musculus	94-97
27294204-3	2016	We found that overexpression of methionine sulfoxide reductase A (MsrA), an antioxidant enzyme that reverses protein methionine oxidation, attenuated ROS-augmented NF-kappaB activation in endothelial cells, in part, by protecting against the oxidation of methionine residues in the regulatory domain of calcium/calmodulin-dependent protein kinase II (CaMKII).	ros	150-153	methionine sulfoxide reductase A	Mus musculus	32-64
27294204-3	2016	We found that overexpression of methionine sulfoxide reductase A (MsrA), an antioxidant enzyme that reverses protein methionine oxidation, attenuated ROS-augmented NF-kappaB activation in endothelial cells, in part, by protecting against the oxidation of methionine residues in the regulatory domain of calcium/calmodulin-dependent protein kinase II (CaMKII).	ros	150-153	methionine sulfoxide reductase A	Mus musculus	66-70
27594970-8	2016	Through our research efforts, we discovered that two genes encoding mitochondrial proteins, one (Ndufc2) involved in OXPHOS complex I assembly and activity and the second one (UCP2) involved in clearance of mitochondrial ROS, are responsible, when dysregulated, for vascular damage in SHRSP.	ros	221-224	NADH:ubiquinone oxidoreductase subunit C2	Homo sapiens	97-103
26376865-5	2015	Biochemical and functional studies showed a marked increase in ROS-induced lipid peroxidation sustained by altered PPARgamma function, which contributes to the redox imbalance and the compensatory antioxidant activity of ALDH1A1.	ros	63-66	aldehyde dehydrogenase 1 family member A1	Homo sapiens	221-228
26587989-3	2015	In a previous study, we demonstrated that glyceraldehyde-derived AGEs increase APP and Abeta via ROS.	ros	97-100	amyloid beta (A4) precursor protein	Mus musculus	87-92
26587989-8	2015	In this report, we demonstrate that AGEs up-regulate APP processing protein (BACE and PS1) and Sirt1 expression via ROS, but do not affect the expression of downstream antioxidant genes HO-1 and NQO-1.	ros	116-119	beta-site APP cleaving enzyme 1	Mus musculus	77-81
26587989-8	2015	In this report, we demonstrate that AGEs up-regulate APP processing protein (BACE and PS1) and Sirt1 expression via ROS, but do not affect the expression of downstream antioxidant genes HO-1 and NQO-1.	ros	116-119	presenilin 1	Mus musculus	86-89
26587989-8	2015	In this report, we demonstrate that AGEs up-regulate APP processing protein (BACE and PS1) and Sirt1 expression via ROS, but do not affect the expression of downstream antioxidant genes HO-1 and NQO-1.	ros	116-119	sirtuin 1	Mus musculus	95-100
26587989-11	2015	Our findings suggest that AGEs increase ROS production, which stimulates downstream pathways related to APP processing, Abeta production, Sirt1, and GRP78, resulting in the up-regulation of cell death related pathway.	ros	40-43	amyloid beta (A4) precursor protein	Mus musculus	120-125
26587989-11	2015	Our findings suggest that AGEs increase ROS production, which stimulates downstream pathways related to APP processing, Abeta production, Sirt1, and GRP78, resulting in the up-regulation of cell death related pathway.	ros	40-43	sirtuin 1	Mus musculus	138-143
26222667-12	2015	These results demonstrated that p53 is responsible for the anti-tumor effect of BA through up-regulation of p66(shc) and miR-21 and down-regulation of Sod2 expression, leading to mitochondrial ROS accumulation and apoptosis.	ros	193-196	transformation related protein 53, pseudogene	Mus musculus	32-35
26410814-6	2015	The fluorescence intensity of ROS and the activities of Caspase-3, Caspase-8, and Caspase-9 were increased.	ros	30-33	caspase 9	Homo sapiens	82-91
26415222-4	2015	Worthy, the copper chelating agent TEPA and the ROS scavenger NAC prevented the aforementioned stimulatory effects.	ros	48-51	synuclein alpha	Homo sapiens	62-65
26450902-5	2015	We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS.	ros	111-114	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	20-24
26450902-5	2015	We also showed that MUL1 inhibited the level of AKT and p-AKT and MUL1 expression was increased by NTP-induced ROS.	ros	111-114	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	66-70
26189441-0	2015	SREBP-1c overactivates ROS-mediated hepatic NF-kappaB inflammatory pathway in dairy cows with fatty liver.	ros	23-26	sterol regulatory element binding transcription factor 1	Mus musculus	0-8
26189441-8	2015	SREBP-1c overexpression overactivated the NF-kappaB inflammatory pathway in hepatocytes by increasing ROS content and not through TLR4.	ros	102-105	sterol regulatory element binding transcription factor 1	Mus musculus	0-8
26189441-9	2015	Furthermore, SREBP-1c silencing decreased ROS content and further attenuated the activation of the NEFA-induced NF-kappaB pathway, thereby decreasing TNF-alpha, IL-6 and IL-1beta synthesis.	ros	42-45	sterol regulatory element binding transcription factor 1	Mus musculus	13-21
26189441-11	2015	Taken together, these results indicate that SREBP-1c enhances the NEFA-induced overactivation of the NF-kappaB inflammatory pathway by increasing ROS in cow hepatocytes, thereby further increasing hepatic inflammatory injury in cows with fatty liver.	ros	146-149	sterol regulatory element binding transcription factor 1	Mus musculus	44-52
26297428-3	2015	Herein, we demonstrated that OGG1 could inhibit the generation of ROS and alleviate mitochondrial dysfunction and increased the expression of IL-1beta caused by PM2.5.	ros	66-69	8-oxoguanine DNA glycosylase	Homo sapiens	29-33
26297428-6	2015	Overexpression of OGG1 inhibited the generation of ROS and the decline in MMP.	ros	51-54	8-oxoguanine DNA glycosylase	Homo sapiens	18-22
26297428-7	2015	Knockdown of OGG1 by RNA interference (RNAi) increased the generation of ROS and reduced the MMP.	ros	73-76	8-oxoguanine DNA glycosylase	Homo sapiens	13-17
25911596-8	2015	An enhanced subcellular level of ROS by spheroidal cluster yielded the high concentrations of L-Kynurenine (1.67 +- 0.6 muM without H2O2, 5.2 +- 1.14 muM with 50 muM of H2O2 and 8.8 +- 0.51 muM with 100 muM of H2O2), supporting the IDO-mediated tryptophan replacement process.	ros	33-36	indoleamine 2,3-dioxygenase 1	Homo sapiens	232-235
26279578-3	2015	Here, we report that cellular ROS enzymatically generated in response to contact with lactobacilli in both mice and Drosophila has salutary effects against exogenous insults to the intestinal epithelium via the activation of Nrf2 responsive cytoprotective genes.	ros	30-33	Keap1	Drosophila melanogaster	225-229
26203587-16	2015	Taken together, these data suggest that TIIA enhances TRAIL-induced apoptosis by upregulating DR5 receptors through the ROS-JNK-CHOP signaling axis in human ovarian carcinoma cells.	ros	120-123	TNF receptor superfamily member 10b	Homo sapiens	94-97
26550302-6	2015	APalpha decreased the intracellular ROS generation and reduced lipid peroxidation induced by Abeta25-35.	ros	36-39	glutamyl aminopeptidase	Rattus norvegicus	0-7
26079889-3	2015	Noteworthy, we have previously demonstrated that EGFR/Rac1/reactive oxygen species (ROS)/matrix metalloproteinase 9 (MMP-9) is a key signaling cascade regulating MUC5AC production in airway cells challenged with LPS.	ros	84-87	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	162-168
25449851-3	2015	We explore these reports and the possibility that activation of the mTOR/p70S6K kinase pathway may represent a ROS-mediated response to mitochondrial stress leading to the activation of senescence.	ros	111-114	ribosomal protein S6 kinase B1	Homo sapiens	73-79
26091901-6	2015	We also found that PAP could increase the generation of intracellular ROS which was a critical mediator in PAP-induced cell growth inhibition.	ros	70-73	regenerating family member 3 alpha	Homo sapiens	19-22
26091901-6	2015	We also found that PAP could increase the generation of intracellular ROS which was a critical mediator in PAP-induced cell growth inhibition.	ros	70-73	regenerating family member 3 alpha	Homo sapiens	107-110
26148005-7	2015	Furthermore, supplementation with NAC reduces ROS production following exposure to DEP.	ros	46-49	synuclein alpha	Homo sapiens	34-37
26148005-11	2015	Addition of NAC suppresses DEP-induced ROS efficiently and reduces subsequent damages by increasing endogenous glutathione.	ros	39-42	synuclein alpha	Homo sapiens	12-15
26710630-10	2015	These results indicated that under low temperature stress, the enhanced activities of PAL could increase the biosynthesis of phenylpropanoid compounds and activate the cellular antioxidant enzymes, which could scavenge the excess ROS and maintain the cellular redox status, and thereby reduce the photo- and oxidative damages caused by low temperature stress.	ros	230-233	phenylalanine ammonia-lyase	Cucumis sativus	86-89
25615876-3	2015	The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs.	ros	208-211	heme oxygenase 1	Homo sapiens	51-67
25615876-3	2015	The results showed that the pretreatment augmented heme oxygenase-1 (HO-1) expression, and at the same time, decreased the phosphorylation of JNK/p38 mitogen-activated protein kinase (MAPK) and intracellular ROS generation in H2O2-treated HUVECs.	ros	208-211	heme oxygenase 1	Homo sapiens	69-73
25615876-4	2015	Moreover, the inhibition of HO-1 expression by tin porphyrin (SnPP) abolished the protective effects of pPolyHb, which suggested that the cytoprotective effect of pPolyHb involves upregulating HO-1 and subsequently decreasing the phosphorylation of the JNK and p38 MAPK and ROS generation.	ros	274-277	heme oxygenase 1	Homo sapiens	28-32
25725288-5	2015	Nek5 silenced cells as well as cells expressing a "kinase dead" version of Nek5, displayed an increase in ROS formation after 4 h of thapsigargin treatment.	ros	106-109	NIMA related kinase 5	Homo sapiens	0-4
25725288-5	2015	Nek5 silenced cells as well as cells expressing a "kinase dead" version of Nek5, displayed an increase in ROS formation after 4 h of thapsigargin treatment.	ros	106-109	NIMA related kinase 5	Homo sapiens	75-79
25857570-10	2015	In addition, Overexpression of DRP1 promoted the activation of p38, the accumulation of ROS, mitochondrial dysfunction, and the synthesis of collagen IV, and all these changes are suppressed by Midivi-1.	ros	88-91	dynamin 1 like	Homo sapiens	31-35
25770995-6	2015	Upon radiation, SeC@MSNs-Tf/TAT promoted intracellular ROS overproduction, which induced apoptotic cell death by affecting p53, AKT and MAPKs pathways.	ros	55-58	transformation related protein 53, pseudogene	Mus musculus	123-126
25620054-7	2015	Inhibition of HO-1 enzymatic activity with SnPPIX and silencing of the HO-1 gene by siRNA enhanced DEP-induced ROS production, further decreased cell viability and increased expression of inflammatory and cell adhesion molecules.	ros	111-114	heme oxygenase 1	Homo sapiens	14-18
25620054-7	2015	Inhibition of HO-1 enzymatic activity with SnPPIX and silencing of the HO-1 gene by siRNA enhanced DEP-induced ROS production, further decreased cell viability and increased expression of inflammatory and cell adhesion molecules.	ros	111-114	heme oxygenase 1	Homo sapiens	71-75
25620054-8	2015	On the other hand, overexpression of the HO-1 gene by a pcDNA 3.1D/V5-HO-1 plasmid significantly mitigated ROS production, increased cell survival and decreased the expression of inflammatory genes.	ros	107-110	heme oxygenase 1	Homo sapiens	41-45
25620054-8	2015	On the other hand, overexpression of the HO-1 gene by a pcDNA 3.1D/V5-HO-1 plasmid significantly mitigated ROS production, increased cell survival and decreased the expression of inflammatory genes.	ros	107-110	heme oxygenase 1	Homo sapiens	70-74
25928429-5	2015	Knockdown of TIGAR exacerbated DNA damage and the effects were partly reversed by the supplementation of PPP products NADPH, ribose, or the ROS scavenger NAC.	ros	140-143	synuclein alpha	Homo sapiens	154-157
25659487-8	2015	We also demonstrated that Pyk2 plays a crucial role in ROS generation during hypoxic stress and that this Pyk2-dependent generation of ROS is necessary for the activation of hypoxia-inducible factor-1alpha, a key molecule in the pathogenesis of hypoxia-induced PH.	ros	55-58	hypoxia inducible factor 1, alpha subunit	Mus musculus	174-205
25659487-8	2015	We also demonstrated that Pyk2 plays a crucial role in ROS generation during hypoxic stress and that this Pyk2-dependent generation of ROS is necessary for the activation of hypoxia-inducible factor-1alpha, a key molecule in the pathogenesis of hypoxia-induced PH.	ros	135-138	hypoxia inducible factor 1, alpha subunit	Mus musculus	174-205
25755250-6	2015	Additionally, GOT2 3K acetylation stimulates NADPH production to suppress ROS and to protect cells from oxidative damage.	ros	74-77	glutamic-oxaloacetic transaminase 2	Homo sapiens	14-18
25655933-4	2015	Furthermore, the activation of the antioxidant enzymes catalase and SOD, downstream FoxO3a targets, was significantly decreased, thereby leading to cell cycle arrest in G1-phase by increased ROS generation and subsequently the activation of the p27(Kip1) pathway.	ros	191-194	interferon alpha inducible protein 27	Homo sapiens	245-248
25655933-4	2015	Furthermore, the activation of the antioxidant enzymes catalase and SOD, downstream FoxO3a targets, was significantly decreased, thereby leading to cell cycle arrest in G1-phase by increased ROS generation and subsequently the activation of the p27(Kip1) pathway.	ros	191-194	cyclin dependent kinase inhibitor 1B	Homo sapiens	249-253
25619390-13	2015	CONCLUSION: Excessive ROS production in DCM activates the TLR-4/MyD-88 signaling, resulting in cardiomyocyte apoptosis, whereas pretreatment with matrine improves cardiac function via suppressing ROS/TLR-4 signaling pathway.	ros	22-25	MYD88, innate immune signal transduction adaptor	Rattus norvegicus	64-70
25287674-8	2015	Pretreatment of the cells with EPO caused a significant blockade of the high glucose-induced increase in ROS and MDA levels and apoptotic rate.	ros	105-108	erythropoietin	Rattus norvegicus	31-34
25537301-9	2015	Moreover, studies also found that ROS acted as an upstream mediator in NB/BDCur-induced HepG2 cell growth inhibition and led to DNA damage with up-regulation of the expression level of phosphorylated ATM and p53.	ros	34-37	ATM serine/threonine kinase	Homo sapiens	200-203
25553592-8	2015	The pretreatment of HepG2 cells with the ROS inhibitor NAC reduced autophagosome formation and reversed the CIT cytotoxicity, indicating that CIT-induced autophagic cell death was ROS-dependent.	ros	180-183	synuclein alpha	Homo sapiens	55-58
25544768-6	2015	HIF-2alpha-mediated SERPINB3 up-regulation under hypoxic conditions required intracellular generation of ROS.	ros	105-108	endothelial PAS domain protein 1	Homo sapiens	0-10
25544768-6	2015	HIF-2alpha-mediated SERPINB3 up-regulation under hypoxic conditions required intracellular generation of ROS.	ros	105-108	serpin family B member 3	Homo sapiens	20-28
25044439-6	2015	Furthermore, inhibition of JNK3 induced accumulation of both acidic compartment and p62, and upregulated ROS production.	ros	105-108	mitogen-activated protein kinase 10	Homo sapiens	27-31
25413785-9	2015	The levels of pro-apoptotic makers p53 and Bax were highly expressed in the diabetic groups indicating oxidative stress through ROS induced by high cytosolic calcium skewing the cells towards apoptosis.	ros	128-131	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	35-38
25413785-9	2015	The levels of pro-apoptotic makers p53 and Bax were highly expressed in the diabetic groups indicating oxidative stress through ROS induced by high cytosolic calcium skewing the cells towards apoptosis.	ros	128-131	BCL2 associated X, apoptosis regulator	Rattus norvegicus	43-46
24929663-6	2015	These in turn activate production of ROS and nitrosactive agents which slowly sensitize NKCC1, explaining why cell swelling and brain edema generally are delayed under hyperammonemic conditions, although very high ammonia concentrations can cause immediate NKCC1 activation.	ros	37-40	solute carrier family 12 member 2	Homo sapiens	88-93
24929663-6	2015	These in turn activate production of ROS and nitrosactive agents which slowly sensitize NKCC1, explaining why cell swelling and brain edema generally are delayed under hyperammonemic conditions, although very high ammonia concentrations can cause immediate NKCC1 activation.	ros	37-40	solute carrier family 12 member 2	Homo sapiens	257-262
25628043-2	2015	However, as a key component of NADPH oxidase, how p47phox regulates NADPH oxidases activity, ROS production and adventitial fibroblasts (AFs) function remains unclear.	ros	93-96	neutrophil cytosolic factor 1	Mus musculus	50-57
35366902-15	2022	Moreover, we validated that down-regulation of GLS1 contributes to ROS generation and bioenergetics interruption induced by B28.	ros	67-70	glutaminase	Homo sapiens	47-51
35152003-7	2022	Tipe1 deficiency upregulated ATP levels, mitochondrial membrane potential, and respiration rate, but downregulated mitochondrial ROS levels in RTECs.	ros	129-132	tumor necrosis factor, alpha-induced protein 8-like 1	Mus musculus	0-5
35453350-5	2022	Carnosine (beta-alanyl-L-histidine, Car) protects cells from the damage due to the reactive species derived from oxygen (ROS), nitrogen (RNS) or carbonyl groups (RCS).	ros	121-124	CXADR pseudogene 1	Homo sapiens	36-39
34995734-14	2022	Besides, protein-protein interaction (PPI) analysis demonstrated that a network consisted of FOXM1, CCNA2, CCNB1, MYBL2, PLK1 and CDK1 might be response for DATS-induced G2/M cell cycle arrest and increased intracellular ROS.	ros	221-224	cyclin B1	Homo sapiens	107-112
34995734-14	2022	Besides, protein-protein interaction (PPI) analysis demonstrated that a network consisted of FOXM1, CCNA2, CCNB1, MYBL2, PLK1 and CDK1 might be response for DATS-induced G2/M cell cycle arrest and increased intracellular ROS.	ros	221-224	MYB proto-oncogene like 2	Homo sapiens	114-119
34995734-14	2022	Besides, protein-protein interaction (PPI) analysis demonstrated that a network consisted of FOXM1, CCNA2, CCNB1, MYBL2, PLK1 and CDK1 might be response for DATS-induced G2/M cell cycle arrest and increased intracellular ROS.	ros	221-224	cyclin dependent kinase 1	Homo sapiens	130-134
35344105-7	2022	Studies in monocytes indicate that ER stress-induced NLRP3 inflammasome activation occurs by a Ca2+-dependent and ROS-independent mechanism, which is coupled with upregulation of MAMs-resident chaperones, closer ER-mitochondria contacts, as well as mitochondrial depolarization and impaired dynamics.	ros	114-117	NLR family, pyrin domain containing 3	Mus musculus	53-58
35456059-3	2022	It was found that those infections promote plasma ROS enhanced generation and antioxidant defence reduction, especially in relation to glutathione and thioredoxin systems, despite the increased effectiveness of Nrf2 transcription factor in granulocytes.	ros	50-53	thioredoxin	Homo sapiens	151-162
35302183-0	2022	Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-alpha expression in hydroquinone-treated leukemia cells.	ros	78-81	ELAV like RNA binding protein 1	Homo sapiens	36-39
35171184-7	2022	The cellular ROS assay indicated that the supply of ferrous ions dramatically increased the ROS mediated by ART and led to markedly enhanced tumor inhibition in animal tests accompanied by the apoptosis of DOX.	ros	13-16	artemin	Homo sapiens	108-111
35171184-7	2022	The cellular ROS assay indicated that the supply of ferrous ions dramatically increased the ROS mediated by ART and led to markedly enhanced tumor inhibition in animal tests accompanied by the apoptosis of DOX.	ros	92-95	artemin	Homo sapiens	108-111
35093305-0	2022	ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer.	ros	13-16	solute carrier family 16 member 3	Homo sapiens	55-59
35122867-3	2022	DDR may up-regulate glutathione peroxidase 4 (GPX4), which in turn degrade ROS induced by PDT.	ros	75-78	glutathione peroxidase 4	Homo sapiens	20-44
35122867-3	2022	DDR may up-regulate glutathione peroxidase 4 (GPX4), which in turn degrade ROS induced by PDT.	ros	75-78	glutathione peroxidase 4	Homo sapiens	46-50
35122867-8	2022	Further investigation demonstrated PDT could damage DNA and up-regulate GPX4, thus degrading the generated ROS.	ros	107-110	glutathione peroxidase 4	Homo sapiens	72-76
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	105-108	heme oxygenase 1	Homo sapiens	201-205
35286219-6	2022	Mechanistically, raloxifene suppressed NLRP3 inflammasomes activation by lowering the cellular levels of ROS through the modulation of redox signaling mediated via aryl hydrocarbon receptor (AhR)-Nrf2-HO-1 axis or the impaired generation of mitochondrial ROS in a mitophagy-dependent manner.	ros	255-258	heme oxygenase 1	Homo sapiens	201-205
35359876-9	2022	Results: IL-1beta increased the levels of ROS, lipid ROS, and the lipid peroxidation end product malondialdehyde (MDA) and altered ferroptosis-related protein expression in chondrocytes.	ros	42-45	interleukin 1 alpha	Mus musculus	9-17
35359876-9	2022	Results: IL-1beta increased the levels of ROS, lipid ROS, and the lipid peroxidation end product malondialdehyde (MDA) and altered ferroptosis-related protein expression in chondrocytes.	ros	53-56	interleukin 1 alpha	Mus musculus	9-17
35326405-7	2022	A low leptin concentration induced a tocolytic effect by preventing myocytes" contraction, differentiation, and macrophage-induced ROS production.	ros	131-134	leptin	Homo sapiens	6-12
35350568-1	2022	The peroxidase family of peroxiredoxins (PRDXs) plays a vital role in maintaining the intracellular balance of ROS.	ros	111-114	peroxiredoxin 1	Homo sapiens	25-39
35113811-10	2022	Mechanistically, DCIR regulates allergen-induced IgE-mediated mast cell ROS generation and oxidation of calmodulin kinase II (ox-CaMKII).	ros	72-75	C-type lectin domain family 4, member a2	Mus musculus	17-21
35246121-4	2022	Here we evaluated, in a longitudinal cohort of dysglycemic population the relation between the circulating miR-21/ROS/HNE levels and the habit-intervention (HI) after 1 year of follow-up.	ros	114-117	microRNA 21	Homo sapiens	107-113
35068071-7	2022	Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is generated by Ce6 to destroy the "bounce-back" response pathway proteins, such as DDI2 and p97, which can effectively inhibit proteasomes and increase apoptosis.	ros	92-95	melanotransferrin	Homo sapiens	189-192
35269849-5	2022	Treatment of poly(I:C), a synthetic dsRNA analogue binding to toll-like receptor 3 (TLR3), generates ROS, which in turn activates TG2 in dermal fibroblast.	ros	101-104	toll-like receptor 3	Mus musculus	62-82
35269849-5	2022	Treatment of poly(I:C), a synthetic dsRNA analogue binding to toll-like receptor 3 (TLR3), generates ROS, which in turn activates TG2 in dermal fibroblast.	ros	101-104	toll-like receptor 3	Mus musculus	84-88
35269849-5	2022	Treatment of poly(I:C), a synthetic dsRNA analogue binding to toll-like receptor 3 (TLR3), generates ROS, which in turn activates TG2 in dermal fibroblast.	ros	101-104	transglutaminase 2, C polypeptide	Mus musculus	130-133
35090964-5	2022	MiR-221 could influence cell viability and ROS level to counter the combined toxicity of ZEA and DON through targeting directly PTEN gene.	ros	43-46	microRNA 221	Homo sapiens	0-7
35090964-5	2022	MiR-221 could influence cell viability and ROS level to counter the combined toxicity of ZEA and DON through targeting directly PTEN gene.	ros	43-46	phosphatase and tensin homolog	Homo sapiens	128-132
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	ros	130-133	NLR family, pyrin domain containing 3	Mus musculus	144-149
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	ros	116-119	NLR family, pyrin domain containing 3	Mus musculus	130-135
35190902-12	2022	In addition, ROS generation and autophagic activity during VIC calcification were also regulated by miR-22/CAB39 pathway.	ros	13-16	calcium binding protein 39	Homo sapiens	107-112
35216470-5	2022	The mechanism for MET-dependent cytotoxicity on C32 cells was found at the level of PRODH/POX-induced ROS generation and activation of Caspase-3 and Caspase-9 expressions in these cells.	ros	102-105	SAFB like transcription modulator	Homo sapiens	18-21
35216470-5	2022	The mechanism for MET-dependent cytotoxicity on C32 cells was found at the level of PRODH/POX-induced ROS generation and activation of Caspase-3 and Caspase-9 expressions in these cells.	ros	102-105	proline dehydrogenase 1	Homo sapiens	84-89
35166693-6	2022	PERK activation by SB202190 was dependent on mitochondrial ROS production and promoted Ca2+-calcineurin activation.	ros	59-62	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	0-4
35144642-8	2022	Activated ROS-metabolism was identified in METTL7B-overexpressed LUAD cells, accompanied with upregulated protein level of GPX4, HMOX1 and SOD1 and their enzymatic activities.	ros	10-13	glutathione peroxidase 4	Homo sapiens	123-127
35155837-8	2022	Similarly, SOD3 was found to reduce the proliferation, IgE isotype switch, ROS level, and CCL17 and CCL22 productions in B cells.	ros	75-78	superoxide dismutase 3, extracellular	Mus musculus	11-15
34999177-5	2022	In the study of mechanism, we found that alliin might reduce the activation of NLRP3 inflammosome by decreasing intracellular ROS generation.	ros	126-129	NLR family, pyrin domain containing 3	Mus musculus	79-84
35178385-5	2022	The relevance of OXPHOS in breast cancer has been recently defined by the discovery of COX7RP, which promotes mitochondrial respiratory supercomplex assembly and glutamine metabolism: the latter is also shown to promote nucleic acid and fatty acid biosynthesis as well as ROS defense regulation.	ros	272-275	cytochrome c oxidase subunit 7A2 like	Homo sapiens	87-93
35042627-15	2022	CONCLUSION: H2O2 increases ROS levels, which activates the ERK1/2 and p38 MAPK pathways to induce the premature senescence of melanocytes through p21 via a p53-independent pathway and consequently disrupts melanosome transfer.	ros	27-30	H3 histone pseudogene 16	Homo sapiens	146-149
35140609-8	2021	We found that IMD alleviated lung injury and inflammatory response in VILI, mainly in reducing ROS levels, upregulating SOD content, downregulating MDA content, reducing the expression of Bax and caspase-3, and increasing the expression of Bcl-2.	ros	95-98	adrenomedullin 2	Homo sapiens	14-17
35141232-8	2021	Then, rh-omentin exerted neuroprotection against hypoxia/reoxygenation (H/R) injury in N2a cells, indicated by increased cell viability, decreased LDH, ROS generation, and cell apoptotic rate.	ros	152-155	intelectin 1	Homo sapiens	9-16
35061864-7	2022	These results thus provided multiple lines of biological evidence to support a model that BDAA interaction with NS4B may impair the integrity of YFV ROs, which not only inhibits viral RNA replication, but also promotes the release of viral RNA from ROs, which consequentially activates RIG-I and MDA5.	ros	149-152	interferon induced with helicase C domain 1	Homo sapiens	296-300
35058429-8	2022	Specifically, Pex3-/- mice produced elevated amounts of ROS, which damaged germ cell DNA and further activated the signaling pathway of the cell senescence regulatory protein P16-CDK6, resulting in cell cycle arrest and eventually contributing to spermatogenesis dysfunction.	ros	56-59	peroxisomal biogenesis factor 3	Mus musculus	14-18
34718783-0	2022	miR169q and NUCLEAR FACTOR YA8 enhance salt tolerance by activating PEROXIDASE1 expression in response to ROS.	ros	106-109	MIR169q	Zea mays	0-7
34718783-6	2022	Our study reveals a direct functional link between salt stress and a miR169q-NF-YA8 regulatory module that plants use to manage ROS stress and strongly suggests that ZmNF-YA8 can be harnessed as a resource for developing salt-tolerant crop varieties.	ros	128-131	MIR169q	Zea mays	69-76
35041723-9	2022	Exposure to L. mexicana upregulated c-Met expression predominantly in infected neutrophils and c-Met expression influenced ROS release by neutrophils.	ros	123-126	met proto-oncogene	Mus musculus	95-100
35035661-10	2022	Nrf2 knockdown significantly decreased IL1beta expression in LPS/ATP-stimulated RAW264.7 macrophages suggesting that CoQ0 inhibited ROS-mediated NLRP3 inflammasome activation and IL1beta expression was suppressed due to the Nrf2 activation.	ros	132-135	interleukin 1 alpha	Mus musculus	39-46
35035661-10	2022	Nrf2 knockdown significantly decreased IL1beta expression in LPS/ATP-stimulated RAW264.7 macrophages suggesting that CoQ0 inhibited ROS-mediated NLRP3 inflammasome activation and IL1beta expression was suppressed due to the Nrf2 activation.	ros	132-135	NLR family, pyrin domain containing 3	Mus musculus	145-150
35129032-0	2022	Implication of mitochondrial ROS-NLRP3 inflammasome axis during two-hit mediated acute lung injury in mice.	ros	29-32	NLR family, pyrin domain containing 3	Mus musculus	33-38
35002527-11	2022	Mechanistically, the accumulated AGEs promoted hyperactivation of the NLRP3 inflammasome through ROS production.	ros	97-100	NLR family, pyrin domain containing 3	Mus musculus	70-75
29671417-7	2018	These results demonstrate that TLR4 is a primary receptor in SK-N-SH cells, by which Abeta25-35 triggers neuroinflammation, and cyanidin attenuates Abeta-induced inflammation and ROS production mediated by the TLR4/NOX4 pathway, suggesting that inhibition of TLR4 by cyanidin could be beneficial in preventing neuronal cell death in the process of Alzheimer"s disease.	ros	179-182	toll like receptor 4	Homo sapiens	210-214
29898994-8	2018	Heterozygous knockout of FliI facilitated selectively autophagic clearance of aggregates, abatement of ROS levels, and protein oxidative damage, ultimately retarding mammary cancer progression.	ros	103-106	flightless I actin binding protein	Mus musculus	25-29
29487387-5	2018	NRF1 and NRF2 decrease upon MALAT1 targeting was due to transcriptional activation of their negative regulator KEAP1, and resulted in reduced expression of anti-oxidant genes and increased ROS levels.	ros	189-192	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	28-34
30102256-6	2018	Mechanistically, ROS produced in diabetes induced c-Src-dependent but VEGF-C-independent VEGFR3 phosphorylation, and upregulated epsins through the activation of transcription factor AP-1.	ros	17-20	FMS-like tyrosine kinase 4	Mus musculus	89-95
30140002-7	2018	Inhibition of the Trx and Grx systems leads to insufficient reducing power to deoxyribonucleotide production for DNA replication and repair and peroxiredoxin for removal of ROS.	ros	173-176	thioredoxin	Homo sapiens	18-21
29935261-7	2018	Low-dose uncouplers induced STAT3 activation through the mild increase of mitochondrial ROS (mitoROS) generation and the subsequent JAK/STAT3 activation in cardiomyocytes.	ros	88-91	signal transducer and activator of transcription 3	Rattus norvegicus	28-33
25632141-9	2015	Our in vitro data suggest that the absence of TERT increases ROS generation and oxidative damage in neurons induced by pathological tau.	ros	61-64	telomerase reverse transcriptase	Homo sapiens	46-50
25632141-9	2015	Our in vitro data suggest that the absence of TERT increases ROS generation and oxidative damage in neurons induced by pathological tau.	ros	61-64	microtubule associated protein tau	Homo sapiens	132-135
30071860-17	2018	ROS levels were significantly (p &lt; 0.03) increased by glucose and SIRT1 inhibition.	ros	0-3	sirtuin 1	Mus musculus	69-74
26783410-3	2015	hTERT, the catalytic subunit of telomerase, protects against mitochondrial damage by binding to mitochondrial DNA and reducing mitochondrial ROS production.	ros	141-144	telomerase reverse transcriptase	Homo sapiens	0-5
29753142-8	2018	Thereby, the antiviral activity of ROS/Nrf2/HO-1 axis was confirmed in EPC cells.	ros	35-38	heme oxygenase 1	Homo sapiens	44-48
29777502-10	2018	The results suggest that resistance in oxi1-2 mutants is through induction of callose deposition via MAPKs resulting in ROS induction as an early response.	ros	120-123	AGC (cAMP-dependent, cGMP-dependent and protein kinase C) kinase family protein	Arabidopsis thaliana	39-43
25220975-4	2014	TNFalpha was not found to affect nucleus pulposus cells" viability, while it resulted in a ~2.5-fold increase of the intracellular ROS levels, a rapid transient phosphorylation of p38 MAPK and a ROS-dependent activation of JNKs.	ros	131-134	tumor necrosis factor	Bos taurus	0-8
25220975-4	2014	TNFalpha was not found to affect nucleus pulposus cells" viability, while it resulted in a ~2.5-fold increase of the intracellular ROS levels, a rapid transient phosphorylation of p38 MAPK and a ROS-dependent activation of JNKs.	ros	195-198	tumor necrosis factor	Bos taurus	0-8
25134437-4	2014	CSE exposure induced ROS generation and p38 mitogen-activated protein kinase (MAPK) activation that are associated with the activation of apoptosis-regulating signal kinase 1 (ASK-1).	ros	21-24	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	138-174
25134437-4	2014	CSE exposure induced ROS generation and p38 mitogen-activated protein kinase (MAPK) activation that are associated with the activation of apoptosis-regulating signal kinase 1 (ASK-1).	ros	21-24	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	176-181
25134437-5	2014	N-acetylcysteine (a general antioxidant) attenuated the CSE-induced ASK-1 and p38 MAPK activation and cell apoptosis, suggesting a triggering role of ROS in ASK-1/p38 MAPK activation during apoptotic progression.	ros	150-153	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	157-162
25134437-7	2014	Taken together, the data presented in this manuscript demonstrate that the ROS-dependent ASK-1/p38 signaling cascade regulates CSE-induced BEAS-2B cell apoptosis.	ros	75-78	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	89-94
29932202-7	2018	For instance, the highest concentration of the extract (100 mug mL-1) decreases ROS generation by about 30% in SH-SY5Y and 70% in CaCo-2 and K562 cells.	ros	80-83	L1 cell adhesion molecule	Mus musculus	64-68
30050528-14	2018	Specifically, immune complex-mediated and C5a-mediated ROS release were inhibited in a PI3Kdelta-dependent manner.	ros	55-58	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	87-96
25372487-8	2014	[Pt(acac)2(DMS)] administered to SH-SY5Y cells provokes the increment of ROS, generated by NADPH oxidase, responsible for the PKC-epsilon and PKC-delta activation.	ros	73-76	protein kinase C epsilon	Homo sapiens	126-137
29972798-5	2018	Moreover, E-BCSCs exhibit robust NRF2-mediated antioxidant responses, rendering them vulnerable to ROS-induced differentiation and cytotoxicity following suppression of NRF2 or downstream thioredoxin (TXN) and glutathione (GSH) antioxidant pathways.	ros	99-102	thioredoxin	Homo sapiens	201-204
29695835-6	2018	TERT silencing or treatment of NRAS-mutant melanoma with the telomerase-dependent telomere uncapping agent, 6-thio-2"-deoxyguanosine (6-thio-dG), led to rapid cell death, along with evidence of both telomeric and non-telomeric DNA damage, increased ROS levels, and upregulation of a mitochondrial antioxidant adaptive response.	ros	249-252	telomerase reverse transcriptase	Homo sapiens	0-4
25018043-7	2014	We demonstrated that the devastating role of disturbed mitochondrial fission by inhibiting Drp1 contributed to the damaged mitochondria-mediated injury such as ROS generation, cyt-c release and activation of caspase-3.	ros	160-163	collapsin response mediator protein 1	Rattus norvegicus	91-95
25065405-9	2014	In addition, the activation of ROS-ERK pathway by mitochondrial fission induced phosphorylation of serine73 on MITF accelerating its proteasomal degradation.	ros	31-34	melanocyte inducing transcription factor	Homo sapiens	111-115
29898731-13	2018	PC-3 cells lacking p53 and PTEN with reduced ROS levels showed significant activation of Akt and NF-kappaB pathway.	ros	45-48	phosphatase and tensin homolog	Homo sapiens	27-31
29550588-9	2018	The effects of the FABP4 inhibitor reducing lipid-induced ER stress-associated inflammation were related to the reduction of fatty acid-induced intramyocellular lipid deposits, ROS and nuclear factor-kappaB (NF-kappaB) nuclear translocation.	ros	177-180	fatty acid binding protein 4, adipocyte	Mus musculus	19-24
25278564-0	2014	PP2A inactivation by ROS accumulation.	ros	21-24	protein phosphatase 2 phosphatase activator	Homo sapiens	0-4
25010292-9	2014	In addition DNA damage induced ROS generation with simultaneous activation of ATM and ATR upon compound treatment was observed.	ros	31-34	ATM serine/threonine kinase	Homo sapiens	78-81
29542272-6	2018	CONCLUSIONS: Our data identify for the first time that endogenously-generated prothrombin and TLR4 form a shared effector mechanism essential to intracellular ROS generation activated by a group 1 HDM allergen (itself a prothrombinase) or by ligation of viral RNA-sensing TLRs.	ros	159-162	toll like receptor 4	Homo sapiens	94-98
25005756-3	2014	Recent in vitro studies show that LOX-1 activation by ox-LDL and angiotensin II (Ang II) induces angiogenesis via activation of NADPH oxidase and subsequent increase in ROS production.	ros	169-172	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	34-39
29799157-6	2018	Moreover, ALDH2 knockout triggered more ROS generation, hepatocyte apoptosis and impaired mitophagy after CCl4 treatment.	ros	40-43	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	10-15
25116621-5	2014	20(S)-Rh2, but not 20(R)-Rh2, was able to suppress UV-B-induced ROS production in HaCat cells.	ros	64-67	Rh associated glycoprotein	Homo sapiens	6-9
29799157-7	2018	In cultured HSC-T6 cells, ALDH2 knockdown by transfecting with lentivirus vector increased ROS generation and alpha-SMA expression in an in vitro hepatocyte fibrosis model using TGF-beta1.	ros	91-94	aldehyde dehydrogenase 2 family member	Rattus norvegicus	26-31
29875661-6	2018	Further mechanism study revealed that the pro-senescence effect of shikonin was dependent on the increased intercellular ROS generation, which subsequently triggered DNA damage-p53/p21waf axis without activating oncogenes such as Ras and MEK-1.	ros	121-124	transformation related protein 53, pseudogene	Mus musculus	177-180
24910408-6	2014	In addition, in the CCl4 induced HepG2 cells injury model and the CYP3A activity level correlated well with ROS level in several ingredients of SLE treated groups, especially in gamma-schisandrin group.	ros	108-111	C-C motif chemokine ligand 4	Homo sapiens	20-24
29499168-6	2018	Pretreatment of ROS scavenger (NAC) significantly inhibited DEP-induced IL-17A mRNA expression.	ros	16-19	synuclein alpha	Homo sapiens	31-34
24821269-8	2014	Moreover, MeHg-induced ROS over-production appeared to inhibit the activities of GS, down-regulated GLAST and GLT-1 expression in cerebral cortex.	ros	23-26	solute carrier family 1 member 3	Rattus norvegicus	100-105
29512938-0	2018	FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti-ROS after spinal cord injury.	ros	88-91	peroxiredoxin 1	Rattus norvegicus	51-56
29512938-6	2018	Taken together, these results suggest that FGF1 improves functional recovery mainly through inducing PRDX1 expression to increase autophagy and anti-ROS activity after SCI.	ros	149-152	peroxiredoxin 1	Rattus norvegicus	101-106
24685774-7	2014	Our results show that BaP exposure significantly enhanced NO and ROS productions in HaCaT cells.	ros	65-68	prohibitin 2	Homo sapiens	22-25
29274570-11	2018	Our results demonstrate that the GRX2-mediated regulation of O2 -/H2O2 release through the S-glutathionylation of mitochondrial proteins may play an integral role in controlling cellular ROS signaling.	ros	187-190	glutaredoxin 2 (thioltransferase)	Mus musculus	33-37
29854821-9	2018	Finally, Egr1 overexpression or knockdown in diabetic mice could upregulate or downregulate the expression of NOX4 and ROS, and alpha-SMA was also changed.	ros	119-122	early growth response 1	Mus musculus	9-13
24865431-7	2014	Furthermore, exogenous beta2AR agonist therapy further augmented these responses in alveolar macrophages through generation of mitochondrial ROS and subsequent increase of adenylyl cyclase activity.	ros	141-144	adrenergic receptor, beta 2	Mus musculus	23-30
24957606-4	2014	TNF-induced ROS promote nuclear IKKgamma association with ubiquitin and its complex formation with ATM for nuclear export.	ros	12-15	inhibitor of nuclear factor kappa B kinase regulatory subunit gamma	Homo sapiens	32-40
24957606-4	2014	TNF-induced ROS promote nuclear IKKgamma association with ubiquitin and its complex formation with ATM for nuclear export.	ros	12-15	ATM serine/threonine kinase	Homo sapiens	99-102
29335220-4	2018	In turn, excessive ROS induced caspase-3-dependent PKCdelta activation and stimulated NF-kappaB p65 nuclear translocation, resulting in inflammation in the mouse hippocampus.	ros	19-22	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	96-99
24962785-12	2014	We also observed that MRBE-induced ATF3 expression was dependent on ROS and GSK3beta.	ros	68-71	activating transcription factor 3	Homo sapiens	35-39
29335220-7	2018	Our data further showed that activation of ROS-PKCdelta signaling was associated with DJ-1 downregulation, which exerted neuroprotective effects against oxidative stress induced by different neurotoxic agents.	ros	43-46	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	86-90
24959670-5	2014	Stable expression of NT-UCH-L1 decreases cellular ROS levels and protects cells from H2O2, rotenone and CCCP-induced cell death.	ros	50-53	ubiquitin C-terminal hydrolase L1	Homo sapiens	24-30
29335220-8	2018	Adeno-associated viral vector-mediated DJ-1 overexpression in the hippocampus effectively inhibited excessive ROS production, suppressed caspase-3-dependent PKCdelta cleavage, blunted inflammation and ultimately reversed learning and memory deficits in BDE-47-treated mice.	ros	110-113	Parkinson disease (autosomal recessive, early onset) 7	Mus musculus	39-43
29363258-6	2018	Importantly, overexpression of ATF3 causes accumulation of depolarized mitochondria, increased production of mitochondrial ROS, and loss of cell viability.	ros	123-126	activating transcription factor 3	Homo sapiens	31-35
24802406-0	2014	The histone acetyltransferase MOF overexpression blunts cardiac hypertrophy by targeting ROS in mice.	ros	89-92	K(lysine) acetyltransferase 8	Mus musculus	30-33
29421700-7	2018	In the ROS studies, compound 8 (MAO-A inhibitor) reduced the ROS level by 51.2% while compound 13 reduced the ROS level by 61.81%.	ros	7-10	monoamine oxidase A	Homo sapiens	32-37
24802406-10	2014	Mechanically, MOF overexpression increased the expression of Catalase and MnSOD, which blocked TAC-induced ROS and ROS downstream c-Raf-MEK-ERK pathway that promotes hypertrophy.	ros	107-110	K(lysine) acetyltransferase 8	Mus musculus	14-17
24802406-10	2014	Mechanically, MOF overexpression increased the expression of Catalase and MnSOD, which blocked TAC-induced ROS and ROS downstream c-Raf-MEK-ERK pathway that promotes hypertrophy.	ros	115-118	K(lysine) acetyltransferase 8	Mus musculus	14-17
29421700-7	2018	In the ROS studies, compound 8 (MAO-A inhibitor) reduced the ROS level by 51.2% while compound 13 reduced the ROS level by 61.81%.	ros	61-64	monoamine oxidase A	Homo sapiens	32-37
29421700-7	2018	In the ROS studies, compound 8 (MAO-A inhibitor) reduced the ROS level by 51.2% while compound 13 reduced the ROS level by 61.81%.	ros	61-64	monoamine oxidase A	Homo sapiens	32-37
24434637-1	2014	Mitochondrial aldehyde dehydrogenase (ALDH2) protects against cardiac injury via reducing production of 4-hydroxynonenal (4-HNE) and ROS.	ros	133-136	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	38-43
29063384-7	2018	CONCLUSIONS: Panoramic radiography leads to increased Prx I expression in buccal mucosa cells, probably as an adaptive response to eliminate X-ray-induced ROS, except in cells from elderly people.	ros	155-158	peroxiredoxin 1	Homo sapiens	54-59
24885580-8	2014	Treatment with NAC (ROS scavenger) and DPI (NADPH oxidase inhibitor) significantly attenuated visfatin-induced MUC8 and MUC5B expression.	ros	20-23	synuclein alpha	Homo sapiens	15-18
24813612-1	2014	The increased longevity of the C. elegans electron transport chain mutants isp-1 and nuo-6 is mediated by mitochondrial ROS (mtROS) signaling.	ros	120-123	Complex I-B15	Caenorhabditis elegans	85-90
29359425-9	2018	ROS from mitochondria induced DNA damage, which in turn induced OGG1-dependent DNA repair activity through 8-oxoguanine DNA glycosylase 1 (OGG1) expression and activation.	ros	0-3	8-oxoguanine DNA glycosylase	Homo sapiens	64-68
24355201-6	2014	Nevertheless, deficiency in Lon protease led to an increase in ROS production and to an accumulation of carbonylated protein in the mitochondria.	ros	63-66	lon peptidase 1, mitochondrial	Homo sapiens	28-31
24491546-6	2014	PEITC enhances TRAIL-induced apoptosis through the downregulation of cell survival proteins and the upregulation of DR5 receptors through actions on the ROS-induced-p53.	ros	153-156	TNF receptor superfamily member 10b	Homo sapiens	116-119
29359425-9	2018	ROS from mitochondria induced DNA damage, which in turn induced OGG1-dependent DNA repair activity through 8-oxoguanine DNA glycosylase 1 (OGG1) expression and activation.	ros	0-3	8-oxoguanine DNA glycosylase	Homo sapiens	107-137
24583396-5	2014	After CL1-0 cells were transfected with catalase-shRNA, the corresponding ROS (H2O2) level and Cat S, Cat L, or Cat K expression (or activity) was up-regulated, accompanied by an increase in cell migration and invasion.	ros	74-77	adhesion G protein-coupled receptor L1	Homo sapiens	6-9
29359425-9	2018	ROS from mitochondria induced DNA damage, which in turn induced OGG1-dependent DNA repair activity through 8-oxoguanine DNA glycosylase 1 (OGG1) expression and activation.	ros	0-3	8-oxoguanine DNA glycosylase	Homo sapiens	139-143
24583396-6	2014	On the other hand, ROS (H2O2) level, cathepsin S, L, and K activities, cell migration and invasion were decreased in catalase-overexpressed CL1-5 cells.	ros	19-22	adhesion G protein-coupled receptor L1	Homo sapiens	140-143
29410138-5	2018	The results showed that the overexpression of LIP-1 in HeLa cells significantly elevated LDH release (P &lt; 0.05), phosphatidylserine exposure and ROS accumulation.	ros	148-151	PTPRF interacting protein alpha 1	Homo sapiens	46-51
24523287-9	2014	Moreover, reducing the nuclear concentration of Ran is sufficient to induce ROS irrespective of progerin.	ros	76-79	RAN, member RAS oncogene family	Homo sapiens	48-51
29452246-6	2018	In this study we have identified Prdx1, a known scavenger of ROS, to be expressed in pre-hypertrophic chondrocytes in a BMP signaling-dependent manner.	ros	61-64	bone morphogenetic protein 1	Homo sapiens	120-123
24407512-5	2014	Given the homology of APX to ROS-scavenging proteins, this result is consistent with APX4 protecting seedling photosystems from oxidation.	ros	29-32	ascorbate peroxidase 4	Arabidopsis thaliana	85-89
29452246-7	2018	We demonstrate that BMP signaling inhibition increases ROS levels in osteogenic cells.	ros	55-58	bone morphogenetic protein 1	Homo sapiens	20-23
24407512-12	2014	These results indicate that APX4 is involved in the ROS-scavenging process in chloroplasts.	ros	52-55	ascorbate peroxidase 4	Arabidopsis thaliana	28-32
29348461-0	2018	Loss of Cdk5 in breast cancer cells promotes ROS-mediated cell death through dysregulation of the mitochondrial permeability transition pore.	ros	45-48	cyclin dependent kinase 5	Homo sapiens	8-12
29675433-0	2018	Sweet Taste Receptors Mediated ROS-NLRP3 Inflammasome Signaling Activation: Implications for Diabetic Nephropathy.	ros	31-34	NLR family, pyrin domain containing 3	Mus musculus	35-40
24675471-11	2014	Silencing of PHLPP2 not only resulted in considerable restoration of Nrf2 signaling, enhanced Nrf2-ARE binding and reduced Nrf2 ubiquitination but also significantly suppressed tBHP-induced ROS generation and alterations in mitochondrial permeability.	ros	190-193	PH domain and leucine rich repeat protein phosphatase 2	Rattus norvegicus	13-19
24625085-15	2014	CONCLUSIONS: The gold (I) N-heterocyclic carbene complex (C22H26N6AuO2PF6) designated as complex 3 induced ROS and p53 dependent apoptosis in B16F10 cells involving the mitochondrial death pathway along with suppression of melanoma tumor growth by regulating the levels of pro and anti apoptotic factors (p53, p21, NF-kappaB, VEGF and MMP-9).	ros	107-110	transformation related protein 53, pseudogene	Mus musculus	305-308
24269727-0	2014	ROS and RNS induced apoptosis through p53 and iNOS mediated pathway by a dibasic hydroxamic acid molecule in leukemia cells.	ros	0-3	inositol-3-phosphate synthase 1	Homo sapiens	46-50
29675433-1	2018	Previous studies demonstrated that ROS-NLRP3 inflammasome signaling activation was involved in the pathogenesis of diabetic nephropathy (DN).	ros	35-38	NLR family, pyrin domain containing 3	Mus musculus	39-44
29675433-3	2018	Whether high glucose primes ROS-NLRP3 inflammasome signaling via STRs is unclear.	ros	28-31	NLR family, pyrin domain containing 3	Mus musculus	32-37
29675433-7	2018	These combined results support the hypothesis that STRs could be involved in the activation of ROS-NLRP3 inflammasome signaling in the pathogenesis of DN, suggesting that STRs may act as new therapeutic targets of DN.	ros	95-98	NLR family, pyrin domain containing 3	Mus musculus	99-104
29404777-0	2018	Verapamil Inhibits Ser202/Thr205 Phosphorylation of Tau by Blocking TXNIP/ROS/p38 MAPK Pathway.	ros	74-77	microtubule associated protein tau	Homo sapiens	52-55
29024245-0	2018	hace1 Influences zebrafish cardiac development via ROS-dependent mechanisms.	ros	51-54	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	Danio rerio	0-5
24498385-4	2014	Mitochondrial ROS production was increased in endothelial cells after caveolin-1 knockdown; 2-deoxy-D-glucose attenuated this increase, implicating caveolin-1 in control of glycolytic pathways.	ros	14-17	caveolin 1, caveolae protein	Mus musculus	70-80
24498385-4	2014	Mitochondrial ROS production was increased in endothelial cells after caveolin-1 knockdown; 2-deoxy-D-glucose attenuated this increase, implicating caveolin-1 in control of glycolytic pathways.	ros	14-17	caveolin 1, caveolae protein	Mus musculus	148-158
29024245-2	2018	We examined the link between the cardiac phenotypes associated with hace1 loss of function to the expression of the Rho small family GTPase, rac1, which is a known target of HACE1 and promotes ROS production via its interaction with NADPH oxidase holoenzymes.	ros	193-196	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	Danio rerio	68-73
29024245-5	2018	Importantly, this phenotype appears to be directly related to Nox enzyme-dependent ROS production, as both genetic inhibition by nox1 and nox2 morpholinos or pharmacologic rescue using ROS scavenging agents restores normal cardiac structure.	ros	83-86	NADPH oxidase 1	Danio rerio	129-133
24084378-6	2014	Specific binding of ROS-AV170 to CSF1R was confirmed by FACS, ELISA and immunohistochemistry on tissue sections.	ros	20-23	colony stimulating factor 1 receptor	Gallus gallus	33-38
29024245-6	2018	CONCLUSIONS: Our study demonstrates that HACE1 is critical in the normal development and proper function of the vertebrate heart via a ROS-dependent mechanism.	ros	135-138	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	Danio rerio	41-46
29063476-6	2018	Further studies demonstrated that the activation of NLRP3 inflammasome could be attenuated by NAC, an inhibitor of ROS.	ros	115-118	synuclein alpha	Homo sapiens	94-97
24419424-10	2014	Moreover, LKB1 genetic alterations are concurrent with EGFR, KRAS, HER2, and CD74-ROS fusions.	ros	82-85	serine/threonine kinase 11	Homo sapiens	10-14
29554905-12	2018	TC-HW-induced ROS increased NF-kappaB and ATF3 activation, and inhibition of NF-kappaB and ATF3 activation attenuated TC-HW-mediated apoptosis.	ros	14-17	activating transcription factor 3	Homo sapiens	42-46
29554905-13	2018	CONCLUSIONS: Our results suggest that TC-HW may suppress cell proliferation through the downregulation of cyclin D1 via proteasomal degradation and transcriptional inhibition, and may induce apoptosis through ROS-dependent NF-kappaB and ATF3 activation.	ros	209-212	activating transcription factor 3	Homo sapiens	237-241
29348517-9	2018	Taken together, these findings indicate that NDRG2 contributed to the increased sensitivity to ciplatin through the modulation of Bak-to-Mcl-1 ratio regulated by NOX5-ROS-PKR pathway; therefore, we suggest that NDRG2 may be a molecular target for improving the efficacy of drug treatment in cancer patients.	ros	167-170	NDRG family member 2	Homo sapiens	45-50
29348517-9	2018	Taken together, these findings indicate that NDRG2 contributed to the increased sensitivity to ciplatin through the modulation of Bak-to-Mcl-1 ratio regulated by NOX5-ROS-PKR pathway; therefore, we suggest that NDRG2 may be a molecular target for improving the efficacy of drug treatment in cancer patients.	ros	167-170	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	137-142
29348517-9	2018	Taken together, these findings indicate that NDRG2 contributed to the increased sensitivity to ciplatin through the modulation of Bak-to-Mcl-1 ratio regulated by NOX5-ROS-PKR pathway; therefore, we suggest that NDRG2 may be a molecular target for improving the efficacy of drug treatment in cancer patients.	ros	167-170	NADPH oxidase 5	Homo sapiens	162-166
29348517-9	2018	Taken together, these findings indicate that NDRG2 contributed to the increased sensitivity to ciplatin through the modulation of Bak-to-Mcl-1 ratio regulated by NOX5-ROS-PKR pathway; therefore, we suggest that NDRG2 may be a molecular target for improving the efficacy of drug treatment in cancer patients.	ros	167-170	eukaryotic translation initiation factor 2 alpha kinase 2	Homo sapiens	171-174
29128359-6	2018	Silencing UCH-L1 significantly suppressed VEGF-induced ROS levels as well as activation of VEGFR, both of which are required for angiogenesis.	ros	55-58	ubiquitin C-terminal hydrolase L1	Homo sapiens	10-16
29128359-7	2018	This study also showed that UCH-L1 promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS by deubiquitination of NOX4, suggesting that UCH-L1 plays a key role in angiogenesis of HUVECS by regulating ROS levels by deubiquitination of NOX4.	ros	122-125	ubiquitin C-terminal hydrolase L1	Homo sapiens	28-34
29128359-7	2018	This study also showed that UCH-L1 promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS by deubiquitination of NOX4, suggesting that UCH-L1 plays a key role in angiogenesis of HUVECS by regulating ROS levels by deubiquitination of NOX4.	ros	122-125	ubiquitin C-terminal hydrolase L1	Homo sapiens	171-177
29128359-7	2018	This study also showed that UCH-L1 promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS by deubiquitination of NOX4, suggesting that UCH-L1 plays a key role in angiogenesis of HUVECS by regulating ROS levels by deubiquitination of NOX4.	ros	235-238	ubiquitin C-terminal hydrolase L1	Homo sapiens	28-34
29128359-7	2018	This study also showed that UCH-L1 promotes angiogenesis of HUVECs, as well as invasion in cancer cells, by up-regulating ROS by deubiquitination of NOX4, suggesting that UCH-L1 plays a key role in angiogenesis of HUVECS by regulating ROS levels by deubiquitination of NOX4.	ros	235-238	ubiquitin C-terminal hydrolase L1	Homo sapiens	171-177
28812210-12	2018	The percentage of Th17 cells was reduced when ROS production was inhibited by NAC, a specific inhibitor of ROS production.	ros	46-49	synuclein alpha	Homo sapiens	78-81
28812210-12	2018	The percentage of Th17 cells was reduced when ROS production was inhibited by NAC, a specific inhibitor of ROS production.	ros	107-110	synuclein alpha	Homo sapiens	78-81
29115404-5	2018	Furthermore, the UQCRB inhibitors decreased mitochondrial ROS generation and mitochondrial membrane potential in the GSCs, indicating that they regulate the mitochondrial function in GSCs.	ros	58-61	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	17-22
24643125-8	2014	The treatment of NAC reduced ROS formation and Ca(2+) content, restored CRAC channel activities and further diminished mitochondrial injuries.	ros	29-32	synuclein alpha	Homo sapiens	17-20
24975608-9	2014	Within mitochondria TERT has been shown to decrease ROS generation, improve respiration, bind to mitochondrial DNA, increase mitochondrial membrane potential and interact with mitochondrial tRNAs.	ros	52-55	telomerase reverse transcriptase	Homo sapiens	20-24
25298619-10	2014	In contrast, miR-146a mimic transfection attenuated HG/thrombin-induced upregulation of Nox4 expression, ROS generation, and inflammatory phenotypes.	ros	105-108	microRNA 146a	Homo sapiens	13-21
24129846-7	2014	The concomitant increase in superoxide dismutase (EC 1.15.1.1) and ascorbate peroxidase (EC 1.11.1.7) may have alleviated the photoinhibition caused by the increased level of ROS in sense plants.	ros	175-178	iron superoxide dismutase	Solanum lycopersicum	28-48
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	26-29	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	151-155
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	194-197	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	151-155
24001789-0	2013	ZnO nanoparticles induce TNF-alpha expression via ROS-ERK-Egr-1 pathway in human keratinocytes.	ros	50-53	early growth response 1	Homo sapiens	58-63
24001789-12	2013	CONCLUSIONS: The present study demonstrated that ZnO-NPs might induce inflammatory response via ROS-ERK-Egr-1 pathway in human keratinocytes.	ros	96-99	early growth response 1	Homo sapiens	104-109
23964117-7	2013	We noticed that all of these signaling molecules, except p38 MAPK and ROS, were indispensable for the induction of MCP-1 and MIP-1alpha.	ros	70-73	chemokine (C-C motif) ligand 3	Mus musculus	125-135
24021285-0	2013	Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice.	ros	48-51	mitogen-activated protein kinase kinase kinase 5	Mus musculus	0-36
24021285-4	2013	The results show that ASK1 acts as a primary mediator of there active oxygen species (ROS) cell death signal cascade in the 3-NP-damaged striatal region by disrupting the positive feedback cycle.	ros	86-89	mitogen-activated protein kinase kinase kinase 5	Mus musculus	22-26
24021285-5	2013	In 3-NP-infused striatal lesions, ROS increased ASK1.	ros	34-37	mitogen-activated protein kinase kinase kinase 5	Mus musculus	48-52
24021285-9	2013	The present study suggests that ROS-inducing ASK1 may be an important step in the pathogenesis of 3-NP infused striatal lesions in murine brains.	ros	32-35	mitogen-activated protein kinase kinase kinase 5	Mus musculus	45-49
29115404-6	2018	Indeed, the knockdown of UQCRB gene by UQCRB siRNA significantly inhibited the cancer stem cell-like phenotypes as well as the expression of stemness markers by blocking mitochondrial ROS/HIF-1alpha/c-Met pathway in U87MG GSCs.	ros	184-187	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	25-30
29115404-6	2018	Indeed, the knockdown of UQCRB gene by UQCRB siRNA significantly inhibited the cancer stem cell-like phenotypes as well as the expression of stemness markers by blocking mitochondrial ROS/HIF-1alpha/c-Met pathway in U87MG GSCs.	ros	184-187	ubiquinol-cytochrome c reductase binding protein	Homo sapiens	39-44
29859938-9	2018	TvSP-induced migration, ROS generation, CD63 expression and IL-8 release were significantly suppressed by pretreatment with OGT inhibitor ST045849 or OGT siRNA.	ros	24-27	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	124-127
29859938-9	2018	TvSP-induced migration, ROS generation, CD63 expression and IL-8 release were significantly suppressed by pretreatment with OGT inhibitor ST045849 or OGT siRNA.	ros	24-27	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	150-153
23801081-8	2013	Increased sensitivity to BCNU-induced ROS production and cell death was confirmed in HEK293 cells inducibly expressing the IDH1 mutants R132H, R132C and R132L.	ros	38-41	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	123-127
29080797-8	2017	Adding DNMT1 inhibitor (5-Aza-2dc) or HDAC1 inhibitor (LBH589) depressed the up-regulation of DNMT1 or HDAC1 expression, the decreases of GSH levels and increases of ROS production induced by OTA, respectively.	ros	166-169	DNA methyltransferase 1	Sus scrofa	7-12
23891589-0	2013	Induction of miR-21-PDCD4 signaling by UVB in JB6 cells involves ROS-mediated MAPK pathways.	ros	65-68	microRNA 21	Homo sapiens	13-19
23891589-3	2013	The results showed that (1) UVB caused PDCD4 inhibition in JB6 cells; (2) exposure of cells to UVB caused a significant increase of miR-21, the upstream regulator of PDCD4, expression; (3) both inhibition of ERKs with U0126 and inhibition of p38 with SB203580 significantly reversed UVB-induced PDCD4 inhibition; (4) ROS scavenger, N-acetyl-l-cysteine reversed the inhibitory effect of UVB on PDCD4 expression.	ros	317-320	microRNA 21	Homo sapiens	132-138
29032183-3	2017	Prdx-1 is an anti-apoptotic and stress response protein which protects cells from damage by ROS and H2O2.	ros	92-95	peroxiredoxin 1	Mus musculus	0-6
29435131-7	2018	Mechanistic studies indicated that upregulation of YAP1 by PD-L1 might be responsible for EGFR mutation-independent TKI resistance via the ROS/HIF-1alpha axis.	ros	139-142	CD274 molecule	Homo sapiens	59-64
24113182-0	2013	Loss of TAK1 increases cell traction force in a ROS-dependent manner to drive epithelial-mesenchymal transition of cancer cells.	ros	48-51	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	8-12
28857396-11	2017	The mechanism involved showed a higher ROS production, which probably activates AP-1 transcription factor and, as a result, ECE-1 expression, increasing ET-1 synthesis, which in consequence induces endothelial senescence.	ros	39-42	endothelin converting enzyme 1	Homo sapiens	124-129
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	fibronectin 1	Rattus norvegicus	431-433
24066693-9	2013	Furthermore, FHC-mediated inhibition of apoptosis depended on suppressing ROS accumulation.	ros	74-77	ferritin heavy chain 1	Homo sapiens	13-16
29299162-9	2017	CDDP-mediated intracellular ROS increment plays an important role in FOXO3-MUL1-AKT signal pathway.	ros	28-31	mitochondrial E3 ubiquitin protein ligase 1	Homo sapiens	75-79
29133922-7	2017	We also found that ROS-mediated activation of ASK1/p38MAPK was involved and adding antioxidants, p38MAPK inhibitor, or genetic repression of ASK1 could easily rescue the cellular damage.	ros	19-22	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	46-50
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	157-160	peroxiredoxin 3	Rattus norvegicus	65-82
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	157-160	peroxiredoxin 3	Rattus norvegicus	84-91
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	303-306	peroxiredoxin 3	Rattus norvegicus	65-82
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	303-306	peroxiredoxin 3	Rattus norvegicus	84-91
29133922-7	2017	We also found that ROS-mediated activation of ASK1/p38MAPK was involved and adding antioxidants, p38MAPK inhibitor, or genetic repression of ASK1 could easily rescue the cellular damage.	ros	19-22	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	141-145
28842171-0	2017	Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells.	ros	97-100	mitogen-activated protein kinase 8	Rattus norvegicus	89-92
23729662-5	2013	Oxysterols treatment led to the activation of the mitochondrial pathway of apoptosis (cytochrome c release and caspase-9 cleavage) and mitochondrial ROS formation, which were suppressed by the pharmacological inhibition or knockdown of sAC.	ros	149-152	adenylate cyclase 10	Rattus norvegicus	236-239
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	ros	214-217	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	48-64
28842171-0	2017	Colistin-induced autophagy and apoptosis involves the JNK-Bcl2-Bax signaling pathway and JNK-p53-ROS positive feedback loop in PC-12 cells.	ros	97-100	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	93-96
23378107-9	2013	While Erk could be an upstream effector of ROS generation, p38MAPK and JNK seem to be associated with ROS-independent cytotoxicity in neonatal rat brain.	ros	102-105	mitogen-activated protein kinase 8	Rattus norvegicus	71-74
28842171-1	2017	Our recent study demonstrated neurotoxicity of colistin-induced autophagy and apoptosis in PC-12 cells, and that autophagy reached peak level at 12 h. In this study, we scrutinized the role of JNK in colistin-induced neurotoxicity and demonstrated the relationship among JNK, p53 and ROS in colistin treated PC-12 cells.	ros	284-287	mitogen-activated protein kinase 8	Rattus norvegicus	193-196
28842171-8	2017	Silencing of p53 by siRNA before colistin treatment substantially reduced ROS production and transactivated JNK in PC-12 cells.	ros	74-77	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	13-16
28842171-9	2017	Moreover, activation of JNK increased ROS generation in PC-12 cells.	ros	38-41	mitogen-activated protein kinase 8	Rattus norvegicus	24-27
23940258-6	2013	Increased iron incorporation into the FtH homopolymer leads to reduced cellular iron availability, diminished levels of cytosolic catalase, SOD1 protein levels, enhanced ROS production and higher levels of oxidized proteins.	ros	170-173	ferritin heavy chain 1	Homo sapiens	38-41
28842171-10	2017	In conclusion, colistin-induced autophagy and apoptosis is correlated to JNK-Bcl2-Bax signaling pathway, and an interaction effect found between intracellular ROS level and JNK-p53 signaling pathway in apoptosis.	ros	159-162	mitogen-activated protein kinase 8	Rattus norvegicus	173-176
28842171-10	2017	In conclusion, colistin-induced autophagy and apoptosis is correlated to JNK-Bcl2-Bax signaling pathway, and an interaction effect found between intracellular ROS level and JNK-p53 signaling pathway in apoptosis.	ros	159-162	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	177-180
29048637-0	2017	Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.	ros	15-18	leptin	Homo sapiens	0-6
23526224-7	2013	Biotinylation and cycloheximide chase assays indicate that CSE-derived ROS increases channel activity, in part, by maintaining cell surface expression of the alpha-ENaC subunit.	ros	71-74	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	158-168
23602911-4	2013	We report herein that arsenite-generated ROS/RNS inhibits PARP-1 activity in cells.	ros	41-44	FAM20C golgi associated secretory pathway kinase	Homo sapiens	45-48
29048637-0	2017	Leptin induces ROS via NOX5 in healthy and neoplastic mammary epithelial cells.	ros	15-18	NADPH oxidase 5	Homo sapiens	23-27
29048637-7	2017	Cell treatment with either siRNA against NOX5, NOX inhibitor DPI or a calcium channel blocker (verapamil) confirmed the putative involvement of the NOX5 isoenzyme in ROS production.	ros	166-169	NADPH oxidase 5	Homo sapiens	41-45
29048637-7	2017	Cell treatment with either siRNA against NOX5, NOX inhibitor DPI or a calcium channel blocker (verapamil) confirmed the putative involvement of the NOX5 isoenzyme in ROS production.	ros	166-169	NADPH oxidase 5	Homo sapiens	148-152
23770211-8	2013	Inhibition of PKCbetaII rescued glucose toxicity-induced generation of ROS and O2(-), apoptosis, cell death and mitochondrial injury (reduced aconitase activity, UCP-2 and PGC-1alpha).	ros	71-74	phospholipase C, beta 2	Rattus norvegicus	14-23
29048637-8	2017	Moreover, cell treatments suppressed ROS production under leptin at both concentrations.	ros	37-40	leptin	Homo sapiens	58-64
29048637-10	2017	Leptin emerged as a potential activator of ROS production in human epithelial mammary cells, where the ROS production was apparently linked to NOX5 activation.	ros	43-46	leptin	Homo sapiens	0-6
29048637-10	2017	Leptin emerged as a potential activator of ROS production in human epithelial mammary cells, where the ROS production was apparently linked to NOX5 activation.	ros	103-106	leptin	Homo sapiens	0-6
23747409-3	2013	The results show increased levels of ROS, NO, protein carbonyls, and 4HNE in N2a/D9 cells, which were attenuated by resistin treatment in a dose dependent manner.	ros	37-40	resistin	Mus musculus	116-124
29212211-6	2017	We demonstrated that SETD7 promoted tumor cell proliferation and prevented cell apoptosis and that SETD7 delicately maintained the redox homeostasis through regulating the levels of GSH/GSSG and ROS.	ros	195-198	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	99-104
23686713-7	2013	Furthermore, hypoxia enhanced ROS production and nitrotyrosine expression in LOX-1 TG mice, supporting the observed pathological changes.	ros	30-33	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	77-82
28723418-3	2017	We thus aimed to investigate if the beta3-AR could be expressed in human macrophages and could trigger its protective role in the myometrium by directly inhibiting ROS production.	ros	164-167	adrenoceptor beta 3	Homo sapiens	36-44
23608524-6	2013	Higher light-dependent DAGK activity (condition b) was also found when ROS were isolated from dark-adapted rat retinas exposed to light.	ros	71-74	diacylglycerol kinase, beta	Rattus norvegicus	23-27
23800068-4	2013	Furthermore, BPO-derived ROS may activate AMPK via ataxia-telangiectasia mutated.	ros	25-28	ATM serine/threonine kinase	Homo sapiens	51-80
23576581-7	2013	These results suggest that cAMP via PKA pathway attenuates the overexpression of Gi proteins and hyperproliferation of VSMC from SHR through the inhibition of ROS and ROS-mediated transactivation of EGF-R/PDGF-R and MAPK signaling pathways.	ros	159-162	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	36-39
23576581-7	2013	These results suggest that cAMP via PKA pathway attenuates the overexpression of Gi proteins and hyperproliferation of VSMC from SHR through the inhibition of ROS and ROS-mediated transactivation of EGF-R/PDGF-R and MAPK signaling pathways.	ros	167-170	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	36-39
28723418-4	2017	Using lipopolysaccharide (LPS)-stimulated myometrial samples and cell co-culture experiments, we demonstrated that beta3-AR stimulation inhibits the activation of the NADPH oxidase, leading to the subsequent inhibition of ROS production by macrophages.	ros	222-225	adrenoceptor beta 3	Homo sapiens	115-123
28946937-10	2017	Our data also suggest that secreted IL-6 regulates CLB2.0-induced MUC5AC and MUC1 expression via ROS-mediated downregulation of claudin-1 expression to maintain mucus homeostasis in the airway.	ros	97-100	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	66-72
28884428-9	2017	The complex induces EAC cell apoptosis through a ROS-mediated mitochondrial pathway by activating caspase 3 and caspase 7 and regulates the Bcl-2 family proteins.	ros	49-52	caspase 7	Mus musculus	112-121
28674855-6	2017	We observed that 6 h pretreatment with CA (1.25, 2.5, 5 muM) decreased RANKL-induced osteoclast formation and abolished RANKL-induced ROS generation by activating Nrf2 and its transcriptional targets.	ros	134-137	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	120-125
23362306-7	2013	AST-120 treatment significantly decreased Mac-1 expression and ROS production in CKD model mice.	ros	63-66	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	0-3
23092805-12	2013	One may speculate that the Ang-II-mediated loss of muscle force is due to an activation of NAD(P)H oxidase expression and a subsequent ROS-induced down regulation of IGF-1, PGC-1alpha and Sirt1.	ros	135-138	sirtuin 1	Mus musculus	188-193
28544069-9	2017	Meanwhile, flow cytometry analysis of mitochondria functions suggested that CD38 decreased intracellular Ca2+ levels in cervical cancer cells and CD38 was involved in down-regulation of ROS levels and prevented mitochondrial apoptosis in cervical cancer cells.	ros	186-189	CD38 molecule	Homo sapiens	76-80
23448276-2	2013	Mitochondria are major producers of ROS, and incubating the colorectal adenocarcinoma cell line HT-29 cells with mitochondrial uncouplers significantly increased endogenous ROS as well as mRNA for both GGT and GCLC (the catalytic subunit of GCL).	ros	36-39	gamma-glutamyltransferase light chain family member 3	Homo sapiens	202-205
28544069-9	2017	Meanwhile, flow cytometry analysis of mitochondria functions suggested that CD38 decreased intracellular Ca2+ levels in cervical cancer cells and CD38 was involved in down-regulation of ROS levels and prevented mitochondrial apoptosis in cervical cancer cells.	ros	186-189	CD38 molecule	Homo sapiens	146-150
28866234-8	2017	CCRI49 could reduce the excess generation of ROS not only by maintaining a higher selective absorption of K+ over Na+ in roots across the membranes through SOS1, AKT1, and HAK5, but also by displaying higher excess-energy dissipation (e.g., higher ETR, PR and qN) during salt stress.	ros	45-48	sodium/hydrogen exchanger 8-like	Gossypium hirsutum	156-160
28866234-8	2017	CCRI49 could reduce the excess generation of ROS not only by maintaining a higher selective absorption of K+ over Na+ in roots across the membranes through SOS1, AKT1, and HAK5, but also by displaying higher excess-energy dissipation (e.g., higher ETR, PR and qN) during salt stress.	ros	45-48	potassium channel AKT1-like	Gossypium hirsutum	162-166
23313662-7	2013	In case of spleen, ROS generation and mitochondrial trans-membrane potential changes promotes intrinsic pathway of apoptosis that was p53 independent, ultimately leads to decrease in CD4(+) T cell population and increase in CD8(+) T cell population.	ros	19-22	transformation related protein 53, pseudogene	Mus musculus	134-137
28715732-0	2017	Proteasome inhibitor-induced cleavage of HSP90 is mediated by ROS generation and caspase 10-activation in human leukemic cells.	ros	62-65	heat shock protein 90 alpha family class A member 1	Homo sapiens	41-46
23313662-8	2013	However in case of thymus, ROS generation and mitochondrial trans-membrane potential changes lead to death receptor that regulate extrinsic and intrinsic pathways of apoptosis and the apoptotic mechanism which was p53 dependent.	ros	27-30	transformation related protein 53, pseudogene	Mus musculus	214-217
28715732-6	2017	MG132 treatment generated ROS, and the cleavage of HSP90 was blocked by a ROS scavenger, N-acetylcysteine (NAC).	ros	74-77	heat shock protein 90 alpha family class A member 1	Homo sapiens	51-56
28715732-11	2017	Taken all together, our results suggest that the cleavage of HSP90 by MG132 treatment is mediated by ROS generation and caspase 10 activation.	ros	101-104	heat shock protein 90 alpha family class A member 1	Homo sapiens	61-66
23644102-2	2013	METHODS: RT-PCR was employed to examine formalin-fixed and paraffin-embedded CCA samples from stage I-IV patients for detection of ROS fusions involving Fused in Glioblastoma (FIG), solute carrier protein (SLC34A2) and major histocompatibility complex class II invariant chain (CD74).	ros	131-134	golgi associated PDZ and coiled-coil motif containing	Homo sapiens	153-174
28750820-4	2017	In cell viability assays, fibroblast viability was reduced 6 h and 24 h after LTP treatment for only 5 min, and pre-treating with NAC, a ROS scavenger, prevented cell loss.	ros	137-140	synuclein alpha	Homo sapiens	130-133
23519235-0	2013	Mitochondrial NDUFS3 regulates the ROS-mediated onset of metabolic switch in transformed cells.	ros	35-38	NADH:ubiquinone oxidoreductase core subunit S3	Homo sapiens	14-20
28734998-12	2017	These results suggest ROS produced by DAB causes tau hyperphosphorylation via GSK-3beta phosphorylation and it might be related to impaired memory deficit.	ros	22-25	glycogen synthase kinase 3 beta	Mus musculus	78-87
23131121-9	2013	These findings correlate with transcriptional up-regulation of the ROS detoxifying mechanisms Sirt1 and Pparg, thus linking triheptanoin with improved mitochondrial status.	ros	67-70	sirtuin 1	Mus musculus	94-99
23395165-2	2013	A new study shows that, upon serine starvation, the tumor suppressor p53 activates p21 to shift metabolic flux from purine biosynthesis to glutathione production, which enhances cellular proliferation and viability by combating ROS (Maddocks et al., 2013).	ros	228-231	H3 histone pseudogene 16	Homo sapiens	83-86
23395171-6	2013	Consequently, Tmem64 deficiency significantly diminishes RANKL-induced [Ca(2+)](i) oscillation, which results in reduced Ca(2+)/calmodulin-dependent protein kinases (CaMK) IV and mitochondrial ROS, both of which contribute to achieving the CREB activity necessary for osteoclast formation.	ros	193-196	transmembrane protein 64	Mus musculus	14-20
23395171-6	2013	Consequently, Tmem64 deficiency significantly diminishes RANKL-induced [Ca(2+)](i) oscillation, which results in reduced Ca(2+)/calmodulin-dependent protein kinases (CaMK) IV and mitochondrial ROS, both of which contribute to achieving the CREB activity necessary for osteoclast formation.	ros	193-196	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	57-62
23267072-10	2013	Inhibition of p66(Shc) expression and mitochondrial translocation by aPC normalized mitochondrial ROS production and the mitochondrial membrane potential in glucose-treated podocytes.	ros	98-101	DNA polymerase delta 3, accessory subunit	Homo sapiens	14-17
23247593-12	2013	CONCLUSION: In U266 cells, berberine suppresses NF-kappaB nuclear translocation via Set9-mediated lysine methylation, leads to decrease in the levels miR21 and Bcl-2, which induces ROS generation and apoptosis.	ros	181-184	SET domain containing 7, histone lysine methyltransferase	Homo sapiens	84-88
24475371-3	2013	We demonstrated that mitochondrial ROS generation is required for the propagation of Notch and beta-catenin signals which promote epidermal differentiation and hair follicle development respectively.	ros	35-38	catenin beta 1	Homo sapiens	95-107
23038752-7	2013	ROS activation of FoxO and NF-kappaB and their downstream targets, atrogin-1 and MuRF1, was observed in M-ERRgamma(-/-) myocytes.	ros	0-3	F-box protein 32	Mus musculus	67-76
23038752-7	2013	ROS activation of FoxO and NF-kappaB and their downstream targets, atrogin-1 and MuRF1, was observed in M-ERRgamma(-/-) myocytes.	ros	0-3	estrogen-related receptor gamma	Mus musculus	106-114
23270407-10	2012	The exposure of these cells to 11.48-14.76 nM of CdS-MD nanoparticles induced ROS production.	ros	78-81	CDP-diacylglycerol synthase 1	Homo sapiens	49-52
23143230-3	2012	AKR1a4 is involved in ascorbate biosynthesis in mice, but has also recently been found to interact with SMAR1, providing a novel mechanism of ROS regulation by ATM.	ros	142-145	BTG3 associated nuclear protein	Mus musculus	104-109
22886911-4	2012	Importantly, by catalyzing proline to P5C, PRODH/POX donates electrons into the electron transport chain to generate ROS or ATP.	ros	117-120	proline dehydrogenase 1	Homo sapiens	43-48
22886911-4	2012	Importantly, by catalyzing proline to P5C, PRODH/POX donates electrons into the electron transport chain to generate ROS or ATP.	ros	117-120	proline dehydrogenase 1	Homo sapiens	49-52
23387079-1	2012	This study is to report the determination of the effect of sodium nitrite induced oxygen species (ROS) on the epithelial-mesenchymal transition in hepatoma cells in mice bearing H22 and investigation of its role in hypoxia-inducible factor 1alpha (HIF-1alpha) in this process.	ros	98-101	hypoxia inducible factor 1, alpha subunit	Mus musculus	248-258
23387079-6	2012	These data indicate sodium nitrite treatment could improve the epithelial-mesenchymal transition of xenografts in mice bearing H22, which might relate to the fact that ROS mediated signal pathway increased the expression of HIF-1alpha.	ros	168-171	hypoxia inducible factor 1, alpha subunit	Mus musculus	224-234
22518836-5	2012	Isolated muscle fibers from the MCK-betaAPP mice also exhibited a reduction in cytoplasmic pH, an increased rate of ROS production, and a partially depolarized plasmalemma.	ros	116-119	amyloid beta (A4) precursor protein	Mus musculus	36-43
22978048-4	2012	A diminished expression of Fas and its counterpart FasL, molecules known to play a major role in cell death, has been described in lymphocytes depleted of O2-reactive oxygen species (ROS), suggesting an involvement of ROS in Fas/FasL expression.	ros	183-186	Fas ligand	Homo sapiens	51-55
22978048-4	2012	A diminished expression of Fas and its counterpart FasL, molecules known to play a major role in cell death, has been described in lymphocytes depleted of O2-reactive oxygen species (ROS), suggesting an involvement of ROS in Fas/FasL expression.	ros	183-186	Fas ligand	Homo sapiens	229-233
22978048-4	2012	A diminished expression of Fas and its counterpart FasL, molecules known to play a major role in cell death, has been described in lymphocytes depleted of O2-reactive oxygen species (ROS), suggesting an involvement of ROS in Fas/FasL expression.	ros	218-221	Fas ligand	Homo sapiens	51-55
22978048-4	2012	A diminished expression of Fas and its counterpart FasL, molecules known to play a major role in cell death, has been described in lymphocytes depleted of O2-reactive oxygen species (ROS), suggesting an involvement of ROS in Fas/FasL expression.	ros	218-221	Fas ligand	Homo sapiens	229-233
22285910-6	2012	Vinca alkaloids and nocodazole caused glutathione/reactive oxygen species (ROS) imbalance, and inhibiting ROS prevented prolonged JNK activation, decreased Mcl-1 levels, MTP loss, and apoptosis.	ros	106-109	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	156-161
22285910-9	2012	These results demonstrate an essential role of ROS in vinca alkaloid-induced aberrant JNK-mediated Mcl-1 downregulation and DNA damage followed by mitochondrial dysfunction-related apoptosis but not mitotic arrest.	ros	47-50	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	99-104
22415872-6	2012	HG caused LPA resistance within RECs by elevating ROS, which activated Src-family kinases that stimulated the extracellular signal-related kinase (Erk) pathway, which antagonized LPA-mediated signaling events that were required for regression.	ros	50-53	Rous sarcoma oncogene	Mus musculus	71-74
22406429-7	2012	Diabetic animals treated with the mitochondria-targeted ROS suppressing peptide MTP-131 also showed improved resistance to PTP opening.	ros	56-59	metallothionein 1B	Homo sapiens	80-83
22548705-4	2012	RESULTS: Senescence evolved over a period of weeks, with initial hyperproliferation followed by cell cycle arrest due to ROS production leading to activation of a DNA damage response and the p53 pathway.	ros	121-124	transformation related protein 53, pseudogene	Mus musculus	191-194
22809160-1	2012	Nitrate reductase (NR) and peroxidase (POX) are important enzymes involved in the metabolism of reactive oxygen (ROS) and nitrogen species in leaves of wheat (Triticum aestivum L.) seedlings.	ros	113-116	peroxidase-like	Triticum aestivum	27-37
22809160-1	2012	Nitrate reductase (NR) and peroxidase (POX) are important enzymes involved in the metabolism of reactive oxygen (ROS) and nitrogen species in leaves of wheat (Triticum aestivum L.) seedlings.	ros	113-116	peroxidase-like	Triticum aestivum	39-42
22809160-8	2012	It is proposed that the changes in light conditions result in the competition between nitrate- and ROS-metabolizing activities of POX in leaves, and a possible interaction between NR and POX controls the levels of NO and ROS in the leaf tissue.	ros	99-102	peroxidase-like	Triticum aestivum	130-133
22809160-8	2012	It is proposed that the changes in light conditions result in the competition between nitrate- and ROS-metabolizing activities of POX in leaves, and a possible interaction between NR and POX controls the levels of NO and ROS in the leaf tissue.	ros	221-224	peroxidase-like	Triticum aestivum	187-190
22086183-8	2012	Thus, these results demonstrate firstly that PLEO has anti-proliferative, anti-survival and pro-apoptotic effects on YD-8 cells and the effects are largely due to the ROS-dependent activation of caspases.	ros	167-170	caspase 9	Homo sapiens	195-203
2551642-0	1989	Non-homologous sequences of parathyroid hormone and the parathyroid hormone related peptide bind to a common receptor on ROS 17/2.8 cells.	ros	121-124	parathyroid hormone-like hormone	Rattus norvegicus	56-91
2551642-1	1989	We and others have recently shown that amino terminal sequences of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), which share a 62% homology within the first 13 residues, bind to the same receptor on ROS 17/2.8 cells.	ros	228-231	parathyroid hormone-like hormone	Rattus norvegicus	97-132
2551642-1	1989	We and others have recently shown that amino terminal sequences of parathyroid hormone (PTH) and parathyroid hormone related peptide (PTHrP), which share a 62% homology within the first 13 residues, bind to the same receptor on ROS 17/2.8 cells.	ros	228-231	parathyroid hormone-like hormone	Rattus norvegicus	134-139
2551642-6	1989	[Tyr36,Cys38]PTHrP(14-38) and [Tyr34]bPTH(14-34)NH2 competed with 125I-NlePTH for binding sites on ROS 17/2.8 cells with apparent Kds of 10 microM and 50 microM respectively.	ros	99-102	parathyroid hormone-like hormone	Rattus norvegicus	13-18
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	ros	14-17	protein kinase C, gamma	Rattus norvegicus	128-131
2537172-3	1989	Incubation of ROS cells with PTH or phorbol 12-myristate 13-acetate (PMA) for 1-30 min caused a rapid and transient decrease in PKC activity in the cytosol, which was associated with a transient increase in PKC activity in the membrane fraction.	ros	14-17	protein kinase C, gamma	Rattus norvegicus	207-210
2537172-7	1989	Chronic treatment of ROS cells for 3 days with PMA caused depletion of total PKC activity in cytosolic and membrane fractions to less than 10% of that in control cells.	ros	21-24	protein kinase C, gamma	Rattus norvegicus	77-80
2537172-9	1989	In addition, chronic treatment of ROS cells with PTH inhibited the responsiveness of PKC activity to subsequent acute PTH challenge, but not to acute PMA challenge, suggesting specific desensitization of this response by PTH.	ros	34-37	protein kinase C, gamma	Rattus norvegicus	85-88
2848035-5	1988	Binding of 125I-[Tyr40]hPTHrp-(1-40) and 125I-labeled [Nle8, Nle18, Tyr34]bovine PTH-(1-34)NH2 to ROS cells was competed for, to the same extent and with the comparable potency, by either unlabeled hPTHrp or PTH peptides.	ros	98-101	parathyroid hormone	Bos taurus	24-27
2848035-5	1988	Binding of 125I-[Tyr40]hPTHrp-(1-40) and 125I-labeled [Nle8, Nle18, Tyr34]bovine PTH-(1-34)NH2 to ROS cells was competed for, to the same extent and with the comparable potency, by either unlabeled hPTHrp or PTH peptides.	ros	98-101	parathyroid hormone	Bos taurus	81-84
2456915-3	1988	Pretreatment of ROS cells for 2 days with the glucocorticoid triamcinolone acetonide (TRM), shifted the dose-response curve for PKA activation by PTH upward compared to the control value.	ros	16-19	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	128-131
33887419-9	2021	RESULTS: The study showed that pre-treatment with AGE downregulated the release of pro-inflammatory mediators (IL-6, TNF-alpha, NO, and ROS) and stimulated the release of anti-inflammatory mediator IL-10 in LPS stimulated RAW 264.7 cells.	ros	136-139	renin binding protein	Mus musculus	50-53
33652126-10	2021	Functionally, the PTEN knockdown experiment using siRNA inhibited serum deprivation-induced cell apoptosis, ROS production, and DNA damage, whereas increased cell proliferation.	ros	108-111	phosphatase and tensin homolog	Rattus norvegicus	18-22
33831169-9	2021	We also observed that excess ROS accumulated in myb21 stamen, and that treatment with dipenyleneiodonium chloride (DPI, a ROS inhibitor) can partly rescue the reduced-fertility of a myb21 mutant.	ros	29-32	myb domain protein 21	Arabidopsis thaliana	48-53
33831169-9	2021	We also observed that excess ROS accumulated in myb21 stamen, and that treatment with dipenyleneiodonium chloride (DPI, a ROS inhibitor) can partly rescue the reduced-fertility of a myb21 mutant.	ros	29-32	myb domain protein 21	Arabidopsis thaliana	182-187
34059352-2	2021	The patient benefitted from sequential TKIs over a 5-year period with response to the third generation ALK/ROS inhibitor, lorlatinib leading to resection of the primary tumor.	ros	107-110	ALK receptor tyrosine kinase	Homo sapiens	103-106
34001648-9	2021	Functionally, CEBPA-AS1 depletion ameliorated OGD/R-induced apoptosis and oxidative stress in SH-SY5Y cells by reducing ROS production and superoxide dismutase (SOD) and glutathione (GSH).	ros	120-123	CEBPA divergent transcript	Homo sapiens	14-23
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	60-63	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	47-52
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	60-63	FBJ osteosarcoma oncogene	Mus musculus	68-73
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	60-63	FBJ osteosarcoma oncogene	Mus musculus	230-235
28651126-6	2017	Moreover, AnexinV/PI analysis showed that cytotoxic effects of TNF-alpha on MCF-7/MX is mediated via apoptosis independent mechanisms and inhibition of RIP1 kinase activity using necrostatin-1 revealed that kinase activity of RIP1 plays role in the production of ROS, activation of JNK and cellular death following exposure of MCF-7/MX cells to TNF-alpha.	ros	263-266	receptor interacting serine/threonine kinase 1	Homo sapiens	152-156
21725356-10	2012	Finally, we demonstrate that in the absence of p53, DJ-1 is stabilized by ROS accumulation, and surprisingly seems to be required for this high intracellular ROS production.	ros	74-77	Parkinsonism associated deglycase	Homo sapiens	52-56
21725356-10	2012	Finally, we demonstrate that in the absence of p53, DJ-1 is stabilized by ROS accumulation, and surprisingly seems to be required for this high intracellular ROS production.	ros	158-161	Parkinsonism associated deglycase	Homo sapiens	52-56
33988537-13	2021	The levels of mitochondrial damage and ROS were reduced after LBP-/- rats were pretreated with rapamycin in the context of LPS-induced sepsis.	ros	39-42	lipopolysaccharide binding protein	Rattus norvegicus	62-65
33436533-6	2021	Transduced Tat-Trx1 markedly inhibited intracellular ROS levels, DNA fragmentation, and cell death in H2O2-treatment HT-22 cells.	ros	53-56	thioredoxin 1	Mus musculus	15-19
33824482-0	2021	Correction: IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.	ros	85-88	Rac family small GTPase 1	Homo sapiens	70-74
28651126-6	2017	Moreover, AnexinV/PI analysis showed that cytotoxic effects of TNF-alpha on MCF-7/MX is mediated via apoptosis independent mechanisms and inhibition of RIP1 kinase activity using necrostatin-1 revealed that kinase activity of RIP1 plays role in the production of ROS, activation of JNK and cellular death following exposure of MCF-7/MX cells to TNF-alpha.	ros	263-266	receptor interacting serine/threonine kinase 1	Homo sapiens	226-230
33515567-7	2021	It should be noted that Prx4 may be directly involved in the protection of ECs from the effects of ROS and function in ECs as a membrane-associated peroxidase.	ros	99-102	peroxiredoxin 4	Homo sapiens	24-28
22098780-4	2012	Protection of NAC against ROS clearly suggested the implication of ROS in hyper-activation of autophagy and cell death.	ros	26-29	synuclein alpha	Homo sapiens	14-17
28651126-7	2017	Overall, it seems that RIP1 ubiquitination and NF-kB activation are prosurvival signaling mediators protecting MCF-7 cells against cytotoxic effects of TNF-alpha while TNF-alpha drives MCF-7/MX cells to non-apoptotic cellular death via kinase activity of RIP1, activation of JNK and ROS production.	ros	283-286	receptor interacting serine/threonine kinase 1	Homo sapiens	23-27
22098780-4	2012	Protection of NAC against ROS clearly suggested the implication of ROS in hyper-activation of autophagy and cell death.	ros	67-70	synuclein alpha	Homo sapiens	14-17
33967677-7	2021	Finally, our proteomic evaluation suggested an anti-inflammatory mechanism of Ang-(1-7) toward the ROS modulators Uchl1 and Prdx1.	ros	99-102	angiogenin	Rattus norvegicus	78-86
28476309-9	2017	Meanwhile, there was a significant decrease in ROS, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels when BRAP was up-regulated by pEGFP-N1-BRAP.	ros	47-50	BRCA1 associated protein	Homo sapiens	137-141
33891667-7	2021	Palmitate-treated podocytes showed increased apoptosis, intracellular ROS, ER stress, inflammation, and fibrosis, and these were significantly attenuated by klotho administration.	ros	70-73	klotho	Mus musculus	157-163
28476309-9	2017	Meanwhile, there was a significant decrease in ROS, interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) levels when BRAP was up-regulated by pEGFP-N1-BRAP.	ros	47-50	BRCA1 associated protein	Homo sapiens	171-175
29088809-5	2017	Further, we found the elevated miR-149 expression by BPIS-induced ROS accumulation, directly targeted the Akt expression to block NF-kappaB nuclear translocation.	ros	66-69	microRNA 149	Homo sapiens	31-38
33959129-3	2021	Intriguingly, in addition to intracellular killing of invading microorganisms and extracellular tissue damage due generation of ROS, soluble MPO has been directly implicated in modulating cellular responses and tissue homeostasis.	ros	128-131	myeloperoxidase	Mus musculus	141-144
21985584-4	2012	Both artrboh mutations modulated the effects of intracellular ROS in the cat2 background, although the predominant effect was mediated by atrbohF.	ros	62-65	cationic amino acid transporter 2	Arabidopsis thaliana	73-77
29088809-6	2017	Taken together, these novel findings provide new insights into the development of BPIS as an anti-inflammatory agent via the signaling cascade of ROS/miR-149/Akt/NF-kappaB axis.	ros	146-149	microRNA 149	Homo sapiens	150-157
33959512-8	2021	Mouse recombinant YM1 decreased the enhanced level of ROS and the colocalized proportion of both xCT and EEA1 in irradiated tumor cells.	ros	54-57	chitinase-like 3	Mus musculus	18-21
28571773-0	2017	DATS sensitizes glioma cells to TRAIL-mediated apoptosis by up-regulation of death receptor 5 via ROS.	ros	98-101	TNF receptor superfamily member 10b	Homo sapiens	77-93
33953705-8	2021	ROS/RNS level was reduced in immune cells after metformin stimulation accompanied by induction of the FOXO3 targets mitochondrial superoxide dismutase and cytochrome c. Studies in Foxo3 deficient (Foxo3-/- ) mouse splenocytes confirmed that metformin mediates its effects via Foxo3 as it attenuates ROS/RNS in myeloid cells of wildtype (WT) but not of Foxo3-/- mice.	ros	0-3	forkhead box O3	Mus musculus	197-202
22124463-0	2012	Sirtuin 1-mediated cellular metabolic memory of high glucose via the LKB1/AMPK/ROS pathway and therapeutic effects of metformin.	ros	79-82	serine/threonine kinase 11	Rattus norvegicus	69-73
28571773-6	2017	In addition, DATS enhances TRAIL-induced apoptosis through the downregulation of anti-apoptotic protein (Mcl-1) and the upregulation of DR5 receptors through actions on the ROS- induced-p53.	ros	173-176	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	105-110
22044588-7	2012	In p53(-/-) and TIGAR(-/-) ischemic myocardium, ROS production was elevated and followed by Bnip3 activation which is an initiator of mitophagy.	ros	48-51	transformation related protein 53, pseudogene	Mus musculus	3-6
33953705-0	2021	Metformin Attenuates ROS via FOXO3 Activation in Immune Cells.	ros	21-24	forkhead box O3	Mus musculus	29-34
33953705-8	2021	ROS/RNS level was reduced in immune cells after metformin stimulation accompanied by induction of the FOXO3 targets mitochondrial superoxide dismutase and cytochrome c. Studies in Foxo3 deficient (Foxo3-/- ) mouse splenocytes confirmed that metformin mediates its effects via Foxo3 as it attenuates ROS/RNS in myeloid cells of wildtype (WT) but not of Foxo3-/- mice.	ros	0-3	forkhead box O3	Mus musculus	180-185
22044588-8	2012	Furthermore, the activation of Bnip3 and mitophagy due to p53/TIGAR inhibition were reversed with antioxidant N-acetyl-cysteine, indicating that this adaptive response requires ROS signal.	ros	177-180	transformation related protein 53, pseudogene	Mus musculus	58-61
28571773-6	2017	In addition, DATS enhances TRAIL-induced apoptosis through the downregulation of anti-apoptotic protein (Mcl-1) and the upregulation of DR5 receptors through actions on the ROS- induced-p53.	ros	173-176	TNF receptor superfamily member 10b	Homo sapiens	136-139
22544998-3	2012	This oxidative stress response occurs in microglia through the activation of the ERK signaling pathway by proinflammatory stimuli, leading to the phosphorylation and translocation of the p47(phox) and p67(phox) cytosolic subunits, the activation of membrane-bound PHOX, and the production of ROS.	ros	292-295	pleckstrin	Homo sapiens	187-196
33953705-8	2021	ROS/RNS level was reduced in immune cells after metformin stimulation accompanied by induction of the FOXO3 targets mitochondrial superoxide dismutase and cytochrome c. Studies in Foxo3 deficient (Foxo3-/- ) mouse splenocytes confirmed that metformin mediates its effects via Foxo3 as it attenuates ROS/RNS in myeloid cells of wildtype (WT) but not of Foxo3-/- mice.	ros	0-3	forkhead box O3	Mus musculus	197-202
33953705-8	2021	ROS/RNS level was reduced in immune cells after metformin stimulation accompanied by induction of the FOXO3 targets mitochondrial superoxide dismutase and cytochrome c. Studies in Foxo3 deficient (Foxo3-/- ) mouse splenocytes confirmed that metformin mediates its effects via Foxo3 as it attenuates ROS/RNS in myeloid cells of wildtype (WT) but not of Foxo3-/- mice.	ros	0-3	forkhead box O3	Mus musculus	197-202
22544998-3	2012	This oxidative stress response occurs in microglia through the activation of the ERK signaling pathway by proinflammatory stimuli, leading to the phosphorylation and translocation of the p47(phox) and p67(phox) cytosolic subunits, the activation of membrane-bound PHOX, and the production of ROS.	ros	292-295	pleckstrin	Homo sapiens	191-195
28319892-8	2017	Increased mitochondrial membrane potential in FTDP-17 neurons leads to overproduction of the ROS in mitochondria, which in turn causes oxidative stress and cell death.	ros	93-96	microtubule associated protein tau	Homo sapiens	46-53
22544998-3	2012	This oxidative stress response occurs in microglia through the activation of the ERK signaling pathway by proinflammatory stimuli, leading to the phosphorylation and translocation of the p47(phox) and p67(phox) cytosolic subunits, the activation of membrane-bound PHOX, and the production of ROS.	ros	292-295	pleckstrin	Homo sapiens	264-268
33872626-5	2021	GOx catalyzed glucose to generate abundant H2O2 for enhancing Fenton reaction, resulting in excessive ROS in tumors.	ros	102-105	hydroxyacid oxidase 1	Homo sapiens	0-3
28463821-0	2017	Mitochondrial ROS induced by chronic ethanol exposure promote hyper-activation of the NLRP3 inflammasome.	ros	14-17	NLR family, pyrin domain containing 3	Mus musculus	86-91
33866247-9	2021	Our data suggest that Hv1-deficiency might aggravate the development of allergic asthma through increasing ROS production.	ros	107-110	hepatitis virus (MHV-2) susceptibility	Mus musculus	22-25
22511847-10	2012	Blocking HMGB1, ROS, or the JNK pathway may attenuate VEGF-A production, suggesting HMGB1 and related signaling molecules play a role in diabetic retinopathy.	ros	16-19	vascular endothelial growth factor A	Rattus norvegicus	54-60
28336091-4	2017	Further research showed that the CYP inducers omeprazole, ethanol, and rifampicin inhibited cell viability, in particular, ethanol, a CYP2E1 inducer, induced ROS generation, lipid peroxidation, and apoptosis in HepG2 cells treated with MC-LR.	ros	158-161	peptidylprolyl isomerase G	Homo sapiens	33-36
23029549-8	2012	When the hAR transgene was crossed onto the PPAR alpha knockout background, another example of greater heart glucose oxidation, hAR expressing mice had increased heart fructose content, cardiac fibrosis, ROS, and apoptosis.	ros	204-207	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	9-12
23029549-8	2012	When the hAR transgene was crossed onto the PPAR alpha knockout background, another example of greater heart glucose oxidation, hAR expressing mice had increased heart fructose content, cardiac fibrosis, ROS, and apoptosis.	ros	204-207	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	128-131
33924609-6	2021	Further study showed that the melatonin receptor mutant cand2 exhibits reduced osmotic stress tolerance with increased ROS accumulation, but exogenous melatonin cannot revert its osmotic stress phenotype.	ros	119-122	Protein of unknown function, transmembrane-40	Arabidopsis thaliana	56-61
33897365-8	2021	In conclusion, the current results suggested that the antihypertensive effect of beta-arrestin1 overexpression in the RVLM is mediated by decreased ROS production, which is associated with Nrf2 activation.	ros	148-151	arrestin, beta 1	Rattus norvegicus	81-95
28516914-5	2017	Mechanistically, hCINAP binds to the C-terminal domain of LDHA, the key regulator of glycolysis, and depends on its adenylate kinase activity to promote LDHA phosphorylation at tyrosine 10, resulting in the hyperactive Warburg effect and the lower cellular ROS level and conferring metabolic advantage to CRCSC invasion.	ros	257-260	adenylate kinase 6	Homo sapiens	17-23
33595911-6	2021	Moreover, the sEH inhibitor trans-4-[4-(3-adamantan-1-y1-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB) prevents cognitive dysfunction and decreased ROS accumulation and apoptosis in the diabetic hippocampus.	ros	147-150	epoxide hydrolase 2, cytoplasmic	Mus musculus	14-17
28271186-8	2017	Meanwhile, SUV39H1 deficiency or inhibition attenuated I/R-induced infarction and improved heart function in mice likely through influencing ROS levels in a SIRT1-dependent manner.	ros	141-144	sirtuin 1	Mus musculus	157-162
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	212-215	2,4-dienoyl-CoA reductase 1	Homo sapiens	114-119
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	212-215	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	164-168
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	212-215	X-linked Kx blood group	Homo sapiens	185-208
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	212-215	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	280-284
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	302-305	2,4-dienoyl-CoA reductase 1	Homo sapiens	114-119
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	302-305	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	164-168
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	302-305	X-linked Kx blood group	Homo sapiens	185-208
23028672-4	2012	Over-expression of miR-145 significantly inhibited the H2O2-induced cellular apoptosis, ROS production, mitochondrial structure disruption as well as the activation of key signaling proteins in mitochondrial apoptotic pathway.	ros	88-91	microRNA 145	Rattus norvegicus	19-26
21685937-5	2011	Cell death induced by depletion of SPARC is dependent on p53 and induction of Bax, and results in the generation of ROS.	ros	116-119	secreted protein acidic and cysteine rich	Homo sapiens	35-40
33636336-7	2021	Importantly, this process could be effectively reversed and rescued by 2DG (a glucose analog capable of producing NADPH, a key antioxidant), A769662 (an allosteric AMPK activator), and N-acetyl cysteine (NAC) (a ROS scavenger), indicating the presence of a vicious circle between AMPK inactivation and ROS in LKB1-mutant NSCLC cells under glucose starvation.	ros	302-305	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	280-284
28074428-3	2017	Transduced WT Tat-DJ-1 proteins increased cell survival and protected against DNA fragmentation and intracellular ROS generation levels in H2O2-exposed HepG2 cells.	ros	114-117	Parkinsonism associated deglycase	Homo sapiens	18-22
33549731-6	2021	Using function-comparative analysis, we found in the current study that YM155 and BIRC5 siRNA both induced early "autophagy-dependent ROS production-mediated" DNA damage/strand breaks and concurrently downregulated the expression of RAD54L, RAD51, and MRE11, which are molecules known for their important roles in homologous recombination, in human cancer (MCF7, MDA-MB-231, and SK-BR-3) and mouse embryonic fibroblast (MEF) cells.	ros	134-137	RAD54 like	Homo sapiens	233-239
33549731-6	2021	Using function-comparative analysis, we found in the current study that YM155 and BIRC5 siRNA both induced early "autophagy-dependent ROS production-mediated" DNA damage/strand breaks and concurrently downregulated the expression of RAD54L, RAD51, and MRE11, which are molecules known for their important roles in homologous recombination, in human cancer (MCF7, MDA-MB-231, and SK-BR-3) and mouse embryonic fibroblast (MEF) cells.	ros	134-137	RAD51 recombinase	Homo sapiens	241-246
22055193-0	2011	ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.	ros	0-3	transformation related protein 53, pseudogene	Mus musculus	13-16
22055193-6	2011	p53 phosphorylation on Ser18 in response to low glucose is ROS and ATM dependent.	ros	59-62	transformation related protein 53, pseudogene	Mus musculus	0-3
21779911-6	2011	ROS scavenger NAC, caffeine and an ATM-specific inhibitor significantly reduced ARV S1133- and sigmaC-induced DNA breaks, DDIT-3 and GADD45alpha expression, H2AX phosphorylation, and apoptosis.	ros	0-3	growth arrest and DNA damage inducible alpha	Gallus gallus	133-144
28103509-7	2017	Collectively, our results suggest that DTMF stimulates ROS-mediated oxidative stress, which in turn induces PERK-CHOP and JNK pathway of apoptosis to promote HCT-116 cell death.	ros	55-58	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	108-112
33780455-0	2021	CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression.	ros	46-49	CD44 molecule (Indian blood group)	Homo sapiens	0-4
28202516-7	2017	This was due to higher ROS production and/or oncogene activation, such as RAS, MYC, and c-SRC.	ros	23-26	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	79-82
33746109-8	2021	Besides, pro-fibrotic cytokine TGF-ss overexpression and NADPH (Nox4) dependent-ROS overproduction are also correlated with the observed cardiac functional and structural modifications.	ros	80-83	NADPH oxidase 4	Rattus norvegicus	64-68
21701768-3	2011	PGP inhibited the production of NO and ROS and expression of iNOS, COX-2, TNF-alpha and IL-1beta, which are involved in the pathogenesis of many inflammation-associated human diseases, including septic shock, hemorrhagic shock and rheumatoid arthritis.	ros	39-42	phosphoglycolate phosphatase	Homo sapiens	0-3
27813153-11	2017	Put together, we present novel findings that ICT, by downregulating TRAF6, coordinates inhibition of NF-kappaB, MAPK/AP-1, and ROS signaling pathways to reduce expression and activity of NFATc1.	ros	127-130	nuclear factor of activated T-cells 1	Rattus norvegicus	187-193
33868142-11	2021	Mechanistically, the WF reduced the liver damage caused by chronic stress in rats by inhibiting the NOX4/ROS/NF-kappaB signaling pathway.	ros	105-108	NADPH oxidase 4	Rattus norvegicus	100-104
21957490-7	2011	Further mechanistic studies revealed that in the absence of Mdm2, ROS induced postnatal p53 activity depletes hematopoietic stem cells, progenitors and differentiated cells.	ros	66-69	transformation related protein 53, pseudogene	Mus musculus	88-91
27431052-9	2017	Coumestrol also caused mitochondrial dysfunction resulting in an increase in ROS production in PC3 and LNCaP cells.	ros	77-80	proprotein convertase subtilisin/kexin type 1	Homo sapiens	95-98
33714955-6	2021	Furthermore, we found that ATF4 inhibition reduced tunicamycin-induced caspase-3 activation, ROS production, ELAM-1 expression, and HTMCs phagocytosis impairment.	ros	93-96	activating transcription factor 4	Homo sapiens	27-31
33754072-6	2021	Results: We found that the upregulation of S100A9 induces cell injury and inflammatory response via NLRP3 activation by targeting VNN1-mediated ROS release; and loss of S100A9 decreases AP injury in vitro and in vivo.	ros	144-147	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	43-49
28011320-7	2017	In autophagy-deficient macrophages, mitochondrial ROS mediated inflammation- and fibrosis-promoting effects by increasing IL1alpha/beta production via enhancing NF-kappaB-associated pathways.	ros	50-53	interleukin 1 alpha	Homo sapiens	122-130
33791150-0	2021	RIP3 mediates TCN-induced necroptosis through activating mitochondrial metabolism and ROS production in chemotherapy-resistant cancers.	ros	86-89	receptor interacting serine/threonine kinase 3	Homo sapiens	0-4
33791150-5	2021	Our current findings reveal that RIP3 mediates TCN-induced necroptosis through up-regulating PYGL and PDC-E1alpha to promote mitochondria energy metabolism and ROS production.	ros	160-163	receptor interacting serine/threonine kinase 3	Homo sapiens	33-37
21664458-0	2011	SIRT3 attenuates palmitate-induced ROS production and inflammation in proximal tubular cells.	ros	35-38	sirtuin 3	Mus musculus	0-5
21664458-3	2011	In this study, we investigated whether SIRT3 reversed renal lipotoxicity-mediated ROS and inflammation.	ros	82-85	sirtuin 3	Mus musculus	39-44
28011320-9	2017	In conclusion, autophagy-deficient Kupffer cells promote liver fibrosis, inflammation and, finally, hepatocarcinogenesis during the preneoplastic stage by enhancing mitochondrial ROS- NF-kappaB-IL1alpha/beta pathways.	ros	179-182	interleukin 1 alpha	Homo sapiens	194-202
21861928-10	2011	In addition, we found that PPCSE induced PI3K/Akt activation via NADPH oxidase/ROS-dependent PDGFR phosphorylation.	ros	79-82	platelet derived growth factor receptor, beta polypeptide	Mus musculus	93-98
28035139-13	2017	Our findings uncover a novel mechanism through which mitochondrial PKM2 phosphorylates Bcl2 and inhibits apoptosis directly, highlight the essential role of PKM2 in ROS adaptation of cancer cells, and implicate HSP90-PKM2-Bcl2 axis as a potential target for therapeutic intervention in glioblastoma.	ros	165-168	pyruvate kinase M1/2	Homo sapiens	67-71
21487413-5	2011	ROS/RNS cause mitochondrial dysfunction by inhibiting the mitochondrial electron transport chain and uncoupling oxidative phosphorylation, which ultimately leads to neuronal bioenergetic failure.	ros	0-3	FAM20C golgi associated secretory pathway kinase	Homo sapiens	4-7
33067693-14	2021	We demonstrated that Nox2/NADPH oxidase-derived ROS play a role in ethanol-induced lipoperoxidation and that this response was prevented by nebivolol.	ros	48-51	cytochrome b-245 beta chain	Rattus norvegicus	21-25
28035139-13	2017	Our findings uncover a novel mechanism through which mitochondrial PKM2 phosphorylates Bcl2 and inhibits apoptosis directly, highlight the essential role of PKM2 in ROS adaptation of cancer cells, and implicate HSP90-PKM2-Bcl2 axis as a potential target for therapeutic intervention in glioblastoma.	ros	165-168	pyruvate kinase M1/2	Homo sapiens	157-161
21487413-7	2011	In the present review, we define a role for ROS/RNS-mediated neuronal bioenergetic failure and apoptosis as a primary mechanism underlying sepsis-associated encephalopathy and, in sepsis survivors, permanent cognitive deficits.	ros	44-47	FAM20C golgi associated secretory pathway kinase	Homo sapiens	48-51
27866262-1	2017	The formation of oligomers and aggregates of overexpressed or mutant alpha-synuclein play a role in the degeneration of dopaminergic neurons in Parkinson"s disease by causing dysfunction of mitochondria, reflected in their disturbed mobility and production of ROS.	ros	260-263	synuclein alpha	Homo sapiens	69-84
21396949-7	2011	Moreover, our results demonstrated that attenuation of GTP by almost 60% augmented the intracellular ROS and nuclear localization of p21 and subsequently led to cell death.	ros	101-104	H3 histone pseudogene 16	Homo sapiens	133-136
32870534-7	2021	RESULTS: We first observed the expression of PINK1 in human PIG1 melanocytes and found that downregulation of PINK1 made melanocytes more sensitive to oxidative stress induced by H2 O2 with more cell apoptosis and increased intracellular ROS.	ros	238-241	PTEN induced kinase 1	Homo sapiens	110-115
33421718-13	2021	In addition, BaP increased mitochondrial ROS production, and Mito-TEMP, a mitochondrial ROS inhibitor, inhibited BaP-induced MUC5AC expression and ERK activation.	ros	88-91	erk	None	147-150
33484825-6	2021	Hyperglycemia, often present in the acute stress condition of ischemia/reperfusion, increases cytosolic ROS concentrations through the activation of NADPH oxidase 2 and increases mitochondrial ROS through the metabolic overloading and decreased binding of hexokinase II to mitochondria.	ros	104-107	cytochrome b-245 beta chain	Homo sapiens	149-164
27866262-5	2017	Accordingly, A53T alpha-synuclein also caused the highest increase in ROS production in the dysmobilized mitochondria in comparison to wild-type or A30P alpha-synuclein.	ros	70-73	synuclein alpha	Homo sapiens	18-33
21367916-9	2011	These findings were related to improved mesangial expansion and to fibronectin and transforming growth factor-beta1 production in response to ANG II and suggest that ANG-(1-7) may attenuate ANG II-stimulated ROS-mediated injury in type 2 diabetic nephropathy.	ros	208-211	fibronectin 1	Mus musculus	67-78
33626368-6	2021	This was associated with increased contributions of non-classical providers of electrons to the electron transport system (ETS) such as the proline dehydrogenase (ProDH) and the mitochondrial glycerol-3-phosphate dehydrogenase (mtG3PDH) alleviating complex I dysfunctions, as well as with increased ROS production per molecule of oxygen consumed.	ros	299-302	sluggish A	Drosophila melanogaster	140-161
28128384-0	2017	Mung bean (Phaseolus radiatus L.) polyphenol extract attenuates aluminum-induced cardiotoxicity through an ROS-triggered Ca2+/JNK/NF-kappaB signaling pathway in rats.	ros	107-110	mitogen-activated protein kinase 8	Rattus norvegicus	126-129
33626368-6	2021	This was associated with increased contributions of non-classical providers of electrons to the electron transport system (ETS) such as the proline dehydrogenase (ProDH) and the mitochondrial glycerol-3-phosphate dehydrogenase (mtG3PDH) alleviating complex I dysfunctions, as well as with increased ROS production per molecule of oxygen consumed.	ros	299-302	sluggish A	Drosophila melanogaster	163-168
33597668-9	2021	In conclusion, our results for the first time proposed that GDF11 protected the post-ICH secondary injury by suppressing the feedback loop between mitochondrial ROS production and mitochondrial dynamic alteration, resulting in attenuated mitochondrial function and amelioration of neural damage.	ros	161-164	growth differentiation factor 11	Rattus norvegicus	60-65
20955683-6	2011	Likewise, the generation of induced pluripotent stem cells from oncogene activation also showed the role of C-MYC and Oct in the regulation of mitochondrial biogenesis and ROS generation.	ros	172-175	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
28128384-7	2017	Therefore, these results showed that MPE has a cardiac protective effect against Al-induced biotoxicity through ROS-JNK and NF-kappaB-mediated caspase pathways.	ros	112-115	mitogen-activated protein kinase 8	Rattus norvegicus	116-119
20955683-6	2011	Likewise, the generation of induced pluripotent stem cells from oncogene activation also showed the role of C-MYC and Oct in the regulation of mitochondrial biogenesis and ROS generation.	ros	172-175	plexin A2	Homo sapiens	118-121
33680286-6	2021	Furthermore, deletion of GCN5L1 could reduce MnSOD acetylation on lysine 68 and activate its activity, thereby scavenging excessive ROS and relieving oxidative stress-induced renal inflammation and fibrosis.	ros	132-135	biogenesis of lysosomal organelles complex-1, subunit 1	Mus musculus	25-31
28255277-9	2017	Knock down of SIRT3 decreased mRNA and protein expression of SOD2 and increased ROS level.	ros	80-83	sirtuin 3	Mus musculus	14-19
33565347-5	2021	Up-regulated Ribulose-5-Phosphate and NADPH/NADP+ level, SOD1, and CAT expression by ouabain enabled OCI-Ly3 cells to resist ROS, while enhanced hypoxanthine and guanine oxidation promoting ROS generation by ouabain, and lowered capacity of scavenging ROS indicated by lowered SOD1 and CAT expression and NADPH/NADP+ levels in Su-DHL4 cells made it more vulnerable to apoptosis through caspase 7 pathway.	ros	125-128	2,4-dienoyl-CoA reductase 1	Homo sapiens	38-43
21420413-6	2011	Knockdown of Nogo-A in cardiomyocytes markedly attenuated hypoxia/reoxygenation-induced apoptosis, as indicated by the significant reduction of DNA fragmentation, phosphatidylserine translocation, and caspase-3 cleavage, by a mechanism involving the preservation of mitochondrial membrane potential, the inhibition of ROS accumulation, and the improvement of intracellular calcium regulation.	ros	318-321	reticulon 4	Homo sapiens	13-19
28255277-14	2017	Overexpression of PGC-1alpha blocked SIRT3 knockdown-induced decrease of SOD2 expression, increase of ROS level, and decrease of mitochondrial function and biogenesis, leading to improvement of osteogenesis.	ros	102-105	sirtuin 3	Mus musculus	37-42
21414301-0	2011	Celastrol induces expression of heme oxygenase-1 through ROS/Nrf2/ARE signaling in the HaCaT cells.	ros	57-60	heme oxygenase 1	Homo sapiens	32-48
33597889-8	2021	Furthermore, mechanistic investigations demonstrated that crizotinib and sunitinib accumulated ROS and inhibited Nrf2 signaling, and that ROS scavenger NAC and Nrf2 agonist tBHQ alleviated the extent of cell damage and the mitochondrial apoptosis during crizotinib- and sunitinib-induced hepatotoxicity in L02 cells.	ros	138-141	X-linked Kx blood group	Homo sapiens	152-155
26856715-11	2017	Functional inhibition of the AhR and AhR-/ARNT-defective cell lines demonstrate that the AhR/ARNT pathway is mandatory for the observed ROS defence caused by ICZ, supporting the hypothesis that AhR-mediated regulation of defence genes is involved.	ros	136-139	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	42-46
33345387-11	2021	In addition, we verified that DIAPH3 could down-regulate cellular ROS level via up-regulating TrxR1 expression.	ros	66-69	thioredoxin reductase 1	Homo sapiens	94-99
21414301-3	2011	In HaCaT cells, celastrol-induced HO-1 expression was dependent on ROS generation.	ros	67-70	heme oxygenase 1	Homo sapiens	34-38
21414301-9	2011	Taken together, our results indicate that celastrol can activate the ROS-ERK/p38-Nrf2-ARE signaling cascades leading to the up-regulation of HO-1 which is partly responsible for its anti-inflammatory activity in the keratinocytes.	ros	69-72	heme oxygenase 1	Homo sapiens	141-145
26856715-11	2017	Functional inhibition of the AhR and AhR-/ARNT-defective cell lines demonstrate that the AhR/ARNT pathway is mandatory for the observed ROS defence caused by ICZ, supporting the hypothesis that AhR-mediated regulation of defence genes is involved.	ros	136-139	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	93-97
27890624-8	2017	Using H89, inhibitor of the protein kinase A (PKA), and protease inhibitors, evidences have been obtained that ROS-dependent apoptosis is associated with an alteration of mitochondrial cAMP/PKA signal that causes degradation/proteolysis of Sirt3 that, in turn, promotes acetylation and proteolytic processing of OPA1.	ros	111-114	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	46-49
33613057-7	2021	Mechanically, the secondary lymphoid organs treated with CCl4 in mice exposed a positive growth in alpha-SMA and collagen expression, increased in proinflammatory cytokine levels and a significant increase in TGF-beta, NO and ROS levels.	ros	226-229	chemokine (C-C motif) ligand 4	Mus musculus	57-61
27890624-8	2017	Using H89, inhibitor of the protein kinase A (PKA), and protease inhibitors, evidences have been obtained that ROS-dependent apoptosis is associated with an alteration of mitochondrial cAMP/PKA signal that causes degradation/proteolysis of Sirt3 that, in turn, promotes acetylation and proteolytic processing of OPA1.	ros	111-114	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	190-193
33501731-0	2021	Photobiomodulation Therapy for Thrombocytopenia by Upregulating Thrombopoietin Expression via the ROS-dependent Src/ERK/STAT3 Signaling Pathway.	ros	98-101	thrombopoietin	Mus musculus	64-78
21319793-10	2011	As a result of oligomerization, the short, calcium-independent splice form, Nox5S, may function as an endogenous inhibitor of calcium-stimulated ROS generation by full-length Nox5.	ros	145-148	NADPH oxidase 5	Homo sapiens	76-80
27890624-8	2017	Using H89, inhibitor of the protein kinase A (PKA), and protease inhibitors, evidences have been obtained that ROS-dependent apoptosis is associated with an alteration of mitochondrial cAMP/PKA signal that causes degradation/proteolysis of Sirt3 that, in turn, promotes acetylation and proteolytic processing of OPA1.	ros	111-114	sirtuin 3	Rattus norvegicus	240-245
33480316-0	2021	Structure-activity insights of harmine targeting DNA, ROS inducing cytotoxicity with PARP mediated apoptosis against cervical cancer, anti-biofilm formation and in vivo therapeutic study.	ros	54-57	poly (ADP-ribose) polymerase family, member 1	Mus musculus	85-89
33480316-17	2021	ROS mediated cytotoxicitywithG2M arrest with PARP mediated apoptosis was studied.	ros	0-3	poly (ADP-ribose) polymerase family, member 1	Mus musculus	45-49
33708107-8	2020	Moreover, autophagy inhibitors, ROS scavenger, Ca2+ chelator and NF-kappaB inhibitor remarkably suppressed c-Fos and NFATc1 expressions.	ros	32-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	107-112
28117341-4	2017	These results strongly suggest that NLRP3 inflammasome serves as a key player in the pathogenesis of IgAN partly through activation of T cells and mitochondrial ROS production and that a local, kidney-targeting suppression of NLRP3 be a therapeutic strategy for IgAN.	ros	161-164	NLR family, pyrin domain containing 3	Mus musculus	36-41
33278392-8	2021	Significantly up-regulated GPX1, SOD2 and GSH contributed to the down-regulated ROS content in SIN-treated groups.	ros	80-83	superoxide dismutase 2	Rattus norvegicus	33-37
33314701-6	2021	OMA1-OPA1 axis is activated by hypoxia, increasing mitochondrial ROS to stabilize HIF-1alpha, thereby promoting glycolysis in colorectal cancer cells.	ros	65-68	OPA1, mitochondrial dynamin like GTPase	Mus musculus	5-9
32640963-11	2021	CONCLUSION: PPG-induced apoptosis was regulated via ROS-mediated BIP/eIF2alpha/CHOP and BIP/ASK1/JNK signaling pathway in colon cancer cells, providing that PPG as a promising therapeutic agent for the treatment of human colon cancer.	ros	52-55	eukaryotic translation initiation factor 2A	Homo sapiens	69-78
21408190-5	2011	In addition, we showed that ETK localizes to mitochondria in bladder cancer cells through interacting with Bcl-XL and regulating ROS production and drug sensitivity.	ros	129-132	BMX non-receptor tyrosine kinase	Homo sapiens	28-31
28117341-4	2017	These results strongly suggest that NLRP3 inflammasome serves as a key player in the pathogenesis of IgAN partly through activation of T cells and mitochondrial ROS production and that a local, kidney-targeting suppression of NLRP3 be a therapeutic strategy for IgAN.	ros	161-164	NLR family, pyrin domain containing 3	Mus musculus	226-231
27864022-9	2017	NAC, an inhibitor of ROS, completely blocked apoptosis, caspase and PARP activation induced by Shikonin.	ros	21-24	synuclein alpha	Homo sapiens	0-3
33515429-6	2021	Inducible nitric oxide synthase (iNOS/NOS-II) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2), the major mediators of reactive nitrogen/oxygen species (RNS/ROS) production in the brain, are also upregulated along with the pro-inflammatory cytokines following neurological insult and contribute to disease progression.	ros	181-184	cytochrome b-245 beta chain	Homo sapiens	50-111
33515429-6	2021	Inducible nitric oxide synthase (iNOS/NOS-II) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 2 (NOX2), the major mediators of reactive nitrogen/oxygen species (RNS/ROS) production in the brain, are also upregulated along with the pro-inflammatory cytokines following neurological insult and contribute to disease progression.	ros	181-184	cytochrome b-245 beta chain	Homo sapiens	113-117
21815067-2	2011	Increased generation of ROS/RNS is implicated in the pathogenesis of a variety of human diseases, including neurodegenerative disease, atherosclerosis, cancer, and aging.	ros	24-27	FAM20C golgi associated secretory pathway kinase	Homo sapiens	28-31
28255307-7	2017	Compared with MSC, MSC-HO-1 significantly attenuated H2O2-induced injury of RGC-5, including decrease in cellular ROS level and apoptosis, activation of antiapoptotic proteins p-Akt and Bcl-2, and blockage of proapoptotic proteins cleaved caspase 3 and Bax.	ros	114-117	heme oxygenase 1	Homo sapiens	23-27
21998736-6	2011	Inhibition of ROS generation by NAC effectively attenuated the activation of ERK and JNK, induction of ER stress, and subsequent apoptosis.	ros	14-17	synuclein alpha	Homo sapiens	32-35
21042727-6	2010	In the presence of p53, increased ROS from OXPHOS increases the expression of p53 target genes known to modulate metabolism, including synthesis of cytochrome c oxidase 2 (SCO2) and TP53-induced glycolysis and apoptosis regulator (TIGAR).	ros	34-37	synthesis of cytochrome C oxidase 2	Homo sapiens	172-176
21108829-6	2010	The inappropriate activation of one of the yeast PKA catalytic subunits, Tpk3p, is sufficient to commit cells to an apoptotic death through transcriptional changes that promote the production of dysfunctional, ROS producing mitochondria.	ros	210-213	cAMP-dependent protein kinase catalytic subunit TPK3	Saccharomyces cerevisiae S288C	73-78
33166869-9	2021	At the sub-cellular levels, PGAM5 deficiency increased mitochondrial DNA copy number and transcript levels, normalized mitochondrial respiration, repressed mitochondrial ROS production, and prevented abnormal mPTP opening upon I/R.	ros	170-173	phosphoglycerate mutase family member 5	Mus musculus	28-33
33171331-0	2021	Regulation of PD-L1 expression in K-ras-driven cancers through ROS-mediated FGFR1 signaling.	ros	63-66	KRAS proto-oncogene, GTPase	Homo sapiens	34-39
33171331-5	2021	We further showed that exogenous ROS such as hydrogen peroxide alone was sufficient to activate FGFR1 and induce PD-L1, while antioxidants could largely abrogate PD-L1 expression in K-ras mutant cells, indicating a critical role of redox regulation.	ros	33-36	KRAS proto-oncogene, GTPase	Homo sapiens	182-187
33171331-7	2021	Our study has identified a novel mechanism by which K-ras promotes PD-L1 expression, and suggests that modulation of ROS or inhibition of the FGFR1 pathway could be a novel strategy to abrogate PD-L1-mediated immunosuppression and thus potentially improve the efficacy of immunotherapy in K-ras-driven cancers.	ros	117-120	KRAS proto-oncogene, GTPase	Homo sapiens	52-57
33171331-7	2021	Our study has identified a novel mechanism by which K-ras promotes PD-L1 expression, and suggests that modulation of ROS or inhibition of the FGFR1 pathway could be a novel strategy to abrogate PD-L1-mediated immunosuppression and thus potentially improve the efficacy of immunotherapy in K-ras-driven cancers.	ros	117-120	KRAS proto-oncogene, GTPase	Homo sapiens	289-294
20568122-8	2010	Taken together, these results suggested that, in bEnd.3 cells, CSE-induced HO-1 expression was mediated through PDGFR/JAK2/STAT3 cascade, which was regulated by c-Src or c-Src activated-NADPH oxidase/ROS.	ros	200-203	platelet derived growth factor receptor, beta polypeptide	Mus musculus	112-117
28004759-9	2016	LR12 also reduced the expression of NLRP3 and caspase-1 p10 protein, and secretion of the IL-1beta, inhibited activation of the NLRP3 inflammasome by decreasing ROS.	ros	161-164	NLR family, pyrin domain containing 3	Mus musculus	128-133
27924062-4	2016	In this study, we for the first time showed that chenodeoxycholic acid (CDCA), the major hydrophobic primary bile acid involved in cholestatic liver injury, could dose-dependently induce NLRP3 inflammasome activation and secretion of pro-inflammatory cytokine-IL-1beta in macrophages by promoting ROS production and K+ efflux.	ros	297-300	NLR family, pyrin domain containing 3	Mus musculus	187-192
23350160-10	2010	Special focus is given to TRX, which are involved in detoxification of ROS and also to their targets.	ros	71-74	thioredoxin	Homo sapiens	26-29
34027095-1	2021	Carbon tetrachloride (CCl4)-induced liver injury is predominantly caused by free radicals, in which mitochondrial function of hepatocytes is impaired, accompanying with the production of ROS and decreased ATP energy supply in animals intoxicated with CCl4.	ros	187-190	chemokine (C-C motif) ligand 4	Mus musculus	22-26
34027095-1	2021	Carbon tetrachloride (CCl4)-induced liver injury is predominantly caused by free radicals, in which mitochondrial function of hepatocytes is impaired, accompanying with the production of ROS and decreased ATP energy supply in animals intoxicated with CCl4.	ros	187-190	chemokine (C-C motif) ligand 4	Mus musculus	251-255
33141059-2	2020	The arsenic biotransformation enzyme AS3MT is known to participate in the generation of ROS after arsenic exposure, whereas MTH1 sanitizes oxidized dNTP pools to prevent the incorporation of damaged bases into DNA.	ros	88-91	arsenite methyltransferase	Homo sapiens	37-42
20815770-4	2010	Furthermore, SHH-F significantly repressed intracellular ROS generation accompanied by adipocyte differentiation.	ros	57-60	sonic hedgehog	Mus musculus	13-16
20815770-5	2010	Thus, lipid-droplet accumulation was shown to positively correlate with ROS upon the differentiation of OP9 preadipocytes into adipocytes and SHH-F significantly suppressed intracellular ROS together with repression of intracellular lipid accumulation.	ros	187-190	sonic hedgehog	Mus musculus	142-145
32985256-9	2020	In terms of mechanism, the renoprotective effect of the GLP-1 would be exerted via the GLP1R-AMPK-mTOR-autophagy-ROS signaling axis.	ros	113-116	glucagon-like peptide 1 receptor	Rattus norvegicus	87-97
27924062-5	2016	Mechanistically, CDCA triggered ROS formation in part through TGR5/EGFR downstream signaling, including protein kinase B, extracellular regulated protein kinases and c-Jun N-terminal kinase pathways.	ros	32-35	epidermal growth factor receptor	Mus musculus	67-71
32985256-9	2020	In terms of mechanism, the renoprotective effect of the GLP-1 would be exerted via the GLP1R-AMPK-mTOR-autophagy-ROS signaling axis.	ros	113-116	mechanistic target of rapamycin kinase	Rattus norvegicus	98-102
27977740-4	2016	MP increases the IL-4 sensitivity of both SHIP+/+ and -/- MFs not by increasing cell surface IL-4 or CD36 receptor levels, but by triggering the activation of Erk and Akt and the production of ROS, all of which play a critical role in sensitizing MFs to IL-4-induced M2 skewing.	ros	193-196	inositol polyphosphate-5-phosphatase D	Mus musculus	42-46
32608557-11	2020	The addition of taurine facilitated IRF7 phosphorylation and enhanced IFN-I production by reducing the ROS levels in pDC in an NCF1-dependent manner.	ros	103-106	neutrophil cytosolic factor 1	Homo sapiens	127-131
27694907-14	2016	CONCLUSION: Physcion induces apoptosis and autophagy in human nasopharyngeal carcinoma by targeting Sp1, which was mediated by ROS/miR-27a/ZBTB10 signaling.	ros	127-130	zinc finger and BTB domain containing 10	Homo sapiens	139-145
32272856-5	2020	Our results outlined that ZnO/CNT@Fe3O4 decreased the proliferative capacity of K562 cells through induction of G1 arrest and induced apoptosis probably via ROS-dependent upregulation of FOXO3a and SIRT1.	ros	157-160	sirtuin 1	Homo sapiens	198-203
32947011-8	2020	CONCLUSION: Our results show that IRP2-Iron-ROS axis is necessary for ART to induce ferroptosis in HSC and play an anti-fibrotic effect.	ros	44-47	iron responsive element binding protein 2	Mus musculus	34-38
20607689-12	2010	The mechanism of fibrosis may involve fructose inducing increased ROS associated with CD11b+F4/80+Gr1+ hepatic macrophage aggregation, resulting in transforming growth factor beta1-signaled collagen deposition and histologically visible hepatic fibrosis.	ros	66-69	hemoglobin, beta adult major chain	Mus musculus	175-180
20213854-2	2010	This phenomenon is independent of yeast metacaspase (Mca1/Yca1) and of calcineurin, requires ROS production and it is concomitant with loss of cellular K(+) and vacuolar collapse.	ros	93-96	Ca(2+)-dependent cysteine protease MCA1	Saccharomyces cerevisiae S288C	53-57
20213854-2	2010	This phenomenon is independent of yeast metacaspase (Mca1/Yca1) and of calcineurin, requires ROS production and it is concomitant with loss of cellular K(+) and vacuolar collapse.	ros	93-96	Ca(2+)-dependent cysteine protease MCA1	Saccharomyces cerevisiae S288C	58-62
27785728-4	2016	BI-1 is a well-conserved protein in plants and animals that serves as the inhibitor of mammalian proapoptotic proteins as well as plant ROS-induced cell death.	ros	136-139	transmembrane BAX inhibitor motif containing 6	Homo sapiens	0-4
20544860-4	2010	In Foxp3 mutant mice (Foxp3(sf)), microglia release higher levels of inflammatory cytokines and mediators such as NO, MCP-1, CXCL10, and ROS upon liposaccharide treatment than the wild type, while TNF-alpha and IL-1 beta were not significantly different between wild and mutant microglial cells.	ros	137-140	forkhead box P3	Mus musculus	3-8
20544860-4	2010	In Foxp3 mutant mice (Foxp3(sf)), microglia release higher levels of inflammatory cytokines and mediators such as NO, MCP-1, CXCL10, and ROS upon liposaccharide treatment than the wild type, while TNF-alpha and IL-1 beta were not significantly different between wild and mutant microglial cells.	ros	137-140	forkhead box P3	Mus musculus	22-27
32823004-5	2020	Preliminary mechanism studies indicated that compound 9o activated Nrf2/HO-1 signaling pathway via accumulation ROS and blocks the NF-kappaB/MAPK signaling pathway.	ros	112-115	heme oxygenase 1	Rattus norvegicus	72-76
33144519-5	2020	We also observed that p101VVKR777AAAA neutrophils showed enhanced p84-dependent ROS responses to fMLP and C5a, suggesting that competition may exist between p101/p110gamma and p84/p110gamma for Gbetagamma subunits downstream of GPCR activation.	ros	80-83	phosphoinositide-3-kinase regulatory subunit 5	Mus musculus	66-69
33144519-5	2020	We also observed that p101VVKR777AAAA neutrophils showed enhanced p84-dependent ROS responses to fMLP and C5a, suggesting that competition may exist between p101/p110gamma and p84/p110gamma for Gbetagamma subunits downstream of GPCR activation.	ros	80-83	phosphoinositide-3-kinase regulatory subunit 5	Mus musculus	176-179
33146789-10	2021	In addition, using the ROS inhibitor N-acetyl-L-cysteine (NAC), we observed abrogated mRNA expression of several ARPs and production of inflammatory cytokines/chemokines (IL-6, IL-8, MCP-1, and CCL-5) in the CSE-challenged cells suggesting an important role of ROS in regulating CSE-induced autophagy.	ros	23-26	C-C motif chemokine ligand 5	Homo sapiens	194-199
26497038-4	2016	Although astrocytes are essential for the antioxidant defense of neurons under oxidative stress, a condition in which a large amount of ROS is generated that may favor the extracellular oxidation of AA and the subsequent neuronal uptake of DHA via GLUT3, potentially increasing oxidative stress in neurons.	ros	136-139	solute carrier family 2 (facilitated glucose transporter), member 3	Mus musculus	248-253
32877205-8	2020	Moreover, prolonged REDD1 expression is associated with cell apoptosis, excessive ROS production and inflammation activation leading to tissue damages.	ros	82-85	DNA damage inducible transcript 4	Homo sapiens	20-25
33035517-10	2020	Moreover, morusin treatment strikingly enhanced intracellular ROS level, an ROS scavenger NAC blocked cell death and changes of Akt, JNK and ERK induced by morusin.	ros	76-79	X-linked Kx blood group	Homo sapiens	90-93
20129611-8	2010	CONCLUSION: Elevation in systemic GGT activity, which is characterized by extended generation of ROS, together with potentially deficient bilirubin-mediated antioxidative capacity of plasma, may therefore constitute key components of the systemic oxidative stress typical of metabolic syndrome.	ros	97-100	gamma-glutamyltransferase light chain family member 3	Homo sapiens	34-37
20188821-8	2010	These results demonstrate that CSPE-induced ROS generation is mediated through a c-Src/NADPH oxidase/MAPK pathway and in turn initiates the activation of Nrf2 and ultimately induces HO-1 expression in HTSMCs.	ros	44-47	heme oxygenase 1	Homo sapiens	182-186
19748668-3	2010	We also found that the generation of ROS was a critical mediator in plumbagin-induced apoptosis, which would be abrogated completely by antioxidant, NAC.	ros	37-40	synuclein alpha	Homo sapiens	149-152
33243934-11	2020	The TS-ROS-NF-kappaB regulatory axis actively involves in pemetrexed-induced PD-L1 upregulation, whereas when pemetrexed fails to induce PD-L1 expression in NSCLC cells, NF-kappaB signaling is unregulated.	ros	7-10	thymidylate synthase	Mus musculus	4-6
32835867-5	2020	This phenotype can be rescued by CTSB inhibition and NAC, which further supported the involvement of ROS and CTSB in apoptosis following sequential treatment.	ros	101-104	cathepsin B	Mus musculus	33-37
32835867-5	2020	This phenotype can be rescued by CTSB inhibition and NAC, which further supported the involvement of ROS and CTSB in apoptosis following sequential treatment.	ros	101-104	NLR family, pyrin domain containing 1A	Mus musculus	53-56
27585948-3	2016	Recently, we reported that Prx5 can regulate activation of microglia cells by governing ROS.	ros	88-91	peroxiredoxin 5	Homo sapiens	27-31
27585948-6	2016	In this study, we demonstrated that Ca2+/calcineurin-dependent de-phosphorylation of Drp1 induces mitochondrial fission and regulates mitochondrial ROS production, which influences the expression of pro-inflammatory mediators in LPS-induced microglia cells.	ros	148-151	interferon regulatory factor 6	Homo sapiens	229-232
33194716-7	2020	Compared with Cos treatment, the autophagy inhibitor 3-MA or ROS scavenger NAC significantly inhibited apoptosis and autophagy.	ros	61-64	X-linked Kx blood group	Homo sapiens	75-78
27585948-8	2016	Prx5 regulates LPS-induced mitochondrial fission through modulation of Ca2+/calcineurin-dependent Drp1 de-phosphorylation by eliminating Nox-derived and cytosolic ROS.	ros	163-166	peroxiredoxin 5	Homo sapiens	0-4
33019842-5	2021	We found that nuclear-aggregated PRCC-TFE3 fusions constitutively activated expression of the target gene E3 ubiquitin ligase PRKN, leading to rapid PINK1-PRKN-dependent mitophagy that promoted cell survival under mitochondrial oxidative damage as well as cell proliferation through decreasing mitochondrial ROS formation.	ros	308-311	PTEN induced kinase 1	Homo sapiens	149-154
27585948-8	2016	Prx5 regulates LPS-induced mitochondrial fission through modulation of Ca2+/calcineurin-dependent Drp1 de-phosphorylation by eliminating Nox-derived and cytosolic ROS.	ros	163-166	interferon regulatory factor 6	Homo sapiens	15-18
26860875-17	2016	GBA1 mutations perturb normal mitochondria functioning by increasing generation of free radical species (ROS) and decreasing adenosine triphosphate (ATP) production, oxygen consumption, and membrane potential.	ros	105-108	glucosylceramidase beta	Homo sapiens	0-4
33194686-10	2020	Moreover, NAC, an ROS scavenger, eliminated the effect of GB-AgNPs on the HeLa and SiHa cells.	ros	18-21	X-linked Kx blood group	Homo sapiens	10-13
20139070-9	2010	These results indicate that Sirt1 overexpression in proximal tubules rescues cisplatin-induced AKI by maintaining peroxisomes number and function, concomitant up-regulation of catalase, and elimination of renal ROS levels.	ros	211-214	sirtuin 1	Mus musculus	28-33
20440404-6	2010	Although the list of mitochondrial proteins identified in this study is incomplete, we identified the downregulation of NDUFS3 from complex I of the respiratory chain and upregulation of COX5A, COX5B, and ATP5H from complex IV and V in ROs.	ros	236-239	NADH:ubiquinone oxidoreductase core subunit S3	Homo sapiens	120-126
27542265-5	2016	We found that docetaxel-resistant PC3 cells (PC3-DR) acquire a pro-invasive behavior undergoing epithelial-to-mesenchymal-transition (EMT) and a decrease of both intracellular ROS and cell growth.	ros	176-179	chromobox 8	Homo sapiens	34-37
19769463-4	2010	Surprisingly, GPx4 knockdown cells showed virtually unchanged levels of intracellular ROS, yet highly increased levels of oxidized lipid by-products.	ros	86-89	glutathione peroxidase 4	Homo sapiens	14-18
33050392-0	2020	Production of ROS by Gallic Acid Activates KDM2A to Reduce rRNA Transcription.	ros	14-17	lysine demethylase 2A	Homo sapiens	43-48
33050392-7	2020	These results suggest that both ROS production and AMPK activation are required for activation of KDM2A by gallic acid.	ros	32-35	lysine demethylase 2A	Homo sapiens	98-103
32607763-8	2020	And ROS stimulation activated the NLRP3 inflammasome which was inhibited by thioredoxin-1.	ros	4-7	thioredoxin 1	Mus musculus	76-89
27542265-5	2016	We found that docetaxel-resistant PC3 cells (PC3-DR) acquire a pro-invasive behavior undergoing epithelial-to-mesenchymal-transition (EMT) and a decrease of both intracellular ROS and cell growth.	ros	176-179	chromobox 8	Homo sapiens	45-48
32607763-10	2020	And the atheroprotective effects of thioredoxin-1 were attenuated by ROS stimulation.	ros	69-72	thioredoxin 1	Mus musculus	36-49
27624558-7	2016	Antioxidants (glutathione and N-Acetylcysteine), Cyp3a inhibitor ketoconazole and SLCO1B1 inhibitor gemfibrozil suppressed cytotoxicity and ROS formation in primary hepatocytes of diabetic rats.	ros	140-143	solute carrier organic anion transporter family member 1B1	Homo sapiens	82-89
32929153-0	2020	Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.	ros	63-66	integrin subunit beta 7	Homo sapiens	80-85
32929153-11	2020	TRIM2 accelerates pancreatic cancer progression via the ROS-related NRF2/ITGB7/FAK axis.	ros	56-59	integrin subunit beta 7	Homo sapiens	73-78
27624558-8	2016	In HepG2 cells, up-regulations of CYP3A4 and SLCO1B1 potentiated hepatotoxicity and ROS generation, whereas knockdowns of CYP3A4 and SLCO1B1 as well as CYP3A4/SLCO1B1 inhibitions showed the opposite effects.	ros	84-87	solute carrier organic anion transporter family member 1B1	Homo sapiens	45-52
27624558-11	2016	All these findings demonstrated that the upregulations of hepatic Cyp3a and SLCO1B1 in diabetic rats potentiated atorvastatin-induced hepatotoxicity via increasing ROS formation.	ros	164-167	solute carrier organic anion transporter family member 1B1	Homo sapiens	76-83
33059314-5	2020	Mechanistically, we demonstrate that deficiency of USF2 promotes survival by inducing mitophagy in a ROS-sensitive manner by activating both ERK1/2 and AKT.	ros	101-104	upstream transcription factor 2, c-fos interacting	Homo sapiens	51-55
27649143-6	2016	Interestingly, the PYK2 mutant increases basal ROS and autophagy levels, and modulates the intensity of RSV effects.	ros	47-50	protein tyrosine kinase 2 beta	Homo sapiens	19-23
33132847-0	2020	Parvalbumin-Deficiency Accelerates the Age-Dependent ROS Production in Pvalb Neurons in vivo: Link to Neurodevelopmental Disorders.	ros	53-56	renin binding protein	Mus musculus	39-42
32887693-3	2020	In the mechanism of protection, Ubc9 overexpression significantly suppressed the MPP+ or PFF-induced ROS generation, while Ubc9-RNAi enhanced the toxicity-induced ROS production.	ros	101-104	ubiquitin-conjugating enzyme E2I	Mus musculus	32-36
32887693-3	2020	In the mechanism of protection, Ubc9 overexpression significantly suppressed the MPP+ or PFF-induced ROS generation, while Ubc9-RNAi enhanced the toxicity-induced ROS production.	ros	163-166	ubiquitin-conjugating enzyme E2I	Mus musculus	123-127
27525436-8	2016	Furthermore, FYN expression was markedly decreased in failing human hearts, corroborating its role as a regulator of cardiac cell death and ROS production.	ros	140-143	FYN proto-oncogene, Src family tyrosine kinase	Homo sapiens	13-16
32497629-15	2020	Collectively, these findings demonstrate that DMF offered vasculoprotective influences on diabetic aortas via attenuation of ROS-TXNIP-NLRP3 inflammasome pathway.	ros	125-128	thioredoxin interacting protein	Rattus norvegicus	129-134
32853879-4	2020	ME1 knockdown increases intracellular ROS levels and impairs lipogenesis in cancer cells, leading to retarded proliferation and increased anoikis, while sparing normal cells.	ros	38-41	malic enzyme 1	Homo sapiens	0-3
32853879-5	2020	Notably, ME1 interference ultimately resulted in adaptive upregulation of mitochondrial IDH2 dependent of AMPK-FoxO1 activation to replenish the NADPH pool and mitigate cytosolic ROS.	ros	179-182	malic enzyme 1	Homo sapiens	9-12
32863205-2	2020	Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrogenase (SDH) drives the ROS production that underlies IR injury.	ros	125-128	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	84-107
32863205-2	2020	Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrogenase (SDH) drives the ROS production that underlies IR injury.	ros	125-128	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	109-112
32729895-8	2020	Accordingly, CD133+CD44+ cells contained lower ROS levels than CD133-CD44- cells, and the low ROS levels in CD133+CD44+ cells were related to the enhancement of antioxidant defense systems.	ros	94-97	CD44 molecule (Indian blood group)	Homo sapiens	19-23
27752226-1	2016	Human body is continuously exposed to different types of agents that results in the production of reactive species called as free radicals (ROS/RNS) which by the transfer of their free unpaired electron causes the oxidation of cellular machinery.	ros	140-143	FAM20C golgi associated secretory pathway kinase	Homo sapiens	144-147
32854424-7	2020	Subsequently, this interaction promotes association with LC3-coated autolysosomes to induce degradation of mitochondria damaged by Cu-induced ROS.	ros	142-145	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	57-60
27472388-7	2016	CD133+ cells also showed increased resistance to all three chemotherapeutic compounds and treatment with Glut1 inhibitor (STF31) reversed this resistance, promoting apoptotic death in these cells similar to CD133- cells.Our study indicates that the altered metabolic profile of CD133+ pancreatic TIC protects them against apoptosis, by reducing accumulation of ROS induced by standard chemotherapeutic agents, thereby confering chemoresistance.	ros	361-364	solute carrier family 2 (facilitated glucose transporter), member 1	Mus musculus	105-110
32533239-6	2020	Moreover, si-DCLK1 increased the chemosensitivity of these cells to cisplatin, as indicated by inhibited cell viability and colony formation, and increased ROS and apoptosis in cisplatin-treated cells.	ros	156-159	doublecortin like kinase 1	Homo sapiens	13-18
32658903-8	2020	In addition, PKClambda knockdown led to increases in cellular ROS levels in ALDH1high cells.	ros	62-65	protein kinase C, iota	Mus musculus	13-22
32658903-9	2020	These results suggest that PKClambda is essential for cancer cell survival and migration, tumorigenesis, the asymmetric distribution of ALDH1A3 protein among cancer cells, and the maintenance of low ROS levels in ALDH1-positive breast cancer stem cells.	ros	199-202	protein kinase C, iota	Mus musculus	27-36
27488950-13	2016	Complexes 1-3 generating cellular ROS caused apoptotic cell death under visible light as evidenced from DCFDA and annexin-V/FITC-PI assays.	ros	34-37	annexin A5	Homo sapiens	114-123
32409143-9	2020	The HO-1 induction was inhibited by a ROS scavenger N-acetylcysteine (NAC), thiol-containing antioxidants (glutathione [GSH] and dithiothreitol [DTT]), JNK and p38 MAPK inhibitors, and nuclear transport inhibitor leptomycin.	ros	38-41	heme oxygenase 1	Rattus norvegicus	4-8
27323401-0	2016	Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.	ros	98-101	microRNA 21	Homo sapiens	126-132
27496964-0	2016	Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.	ros	56-59	EPH receptor B2	Homo sapiens	60-63
32763067-1	2021	BACKGROUND: Targeted therapy for patients with non-small-cell lung cancer (NSCLC) harboring ROS proto-oncogene 1 (ROS1) rearrangements was approved in 2016.	ros	92-95	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	114-118
26947058-6	2016	Recent works have shown that, at variance from VDAC1, VDAC2 and VDAC3 exhibit cysteines predicted to protrude towards the intermembrane space, making them a preferred target for oxidation by ROS.	ros	191-194	voltage dependent anion channel 3	Homo sapiens	64-69
32446355-6	2020	Transient expression of RIN13 in N. benthamiana leaves can accelerate leaf senescence and cell death, and affect the activities of ROS-scavenging enzymes, and the C-terminus of RIN13 is crucial for its function.	ros	131-134	RPM1 interacting protein 13	Arabidopsis thaliana	24-29
27270321-6	2016	In the cells subjected to hypoxia, inhibition of Sirt3-mediated mitophagy further decreased the mitochondrial membrane potential, and increased the accumulation of ROS that triggers the degradation of anti-apoptotic proteins Mcl-1 and survivin through the proteasomal pathway.	ros	164-167	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	225-230
32513988-6	2020	After downregulation of ANRIL by siRNA, ROS level decreased and HASMC phenotypic transition alleviated.	ros	40-43	CDKN2B antisense RNA 1	Homo sapiens	24-29
32513988-7	2020	ANRIL could act as a molecular scaffold to promote the binding of WDR5 and HDAC3 to form WDR5 and HDAC3 complexes, they regulated target genes such as NOX1 expression by histone modification, upregulated ROS level and promote HASMC phenotype transition.	ros	204-207	CDKN2B antisense RNA 1	Homo sapiens	0-5
32587470-9	2020	Immunofluorescence results revealed that ROS production in the agonist-CD137 group was higher than that in control, M5580 (a Nrf2 pathway agonist) and CAPE (a NF-kappaB pathway inhibitor) groups.	ros	41-44	TNF receptor superfamily member 9	Homo sapiens	71-76
27068641-0	2016	High glucose induces autophagy of MC3T3-E1 cells via ROS-AKT-mTOR axis.	ros	53-56	mechanistic target of rapamycin kinase	Mus musculus	61-65
32171159-9	2020	While the ROS scavenger NAC had effectively attenuated the ROS level and suppressed the TGF-beta1/Smad3 signaling pathway.	ros	10-13	NLR family, pyrin domain containing 1A	Mus musculus	24-27
32171159-9	2020	While the ROS scavenger NAC had effectively attenuated the ROS level and suppressed the TGF-beta1/Smad3 signaling pathway.	ros	59-62	NLR family, pyrin domain containing 1A	Mus musculus	24-27
27068641-1	2016	In the present study, we investigate the function of ROS-AKT-mTOR axis on the apoptosis, proliferation and autophagy of MC3T3-E1 cells, and the proliferation of MC3T3-E1 cells after autophagy inhibition under high glucose conditions.	ros	53-56	mechanistic target of rapamycin kinase	Mus musculus	61-65
27068641-15	2016	Our present findings reveal that high glucose affects apoptosis, proliferation and autophagy of MC3T3-E1 cells through ROS-AKT-mTOR axis.	ros	119-122	mechanistic target of rapamycin kinase	Mus musculus	127-131
26302866-6	2016	WI-38/Cyp3a5 cells showed higher cellular ROS levels, higher LDH activities in culture media, but lower cellular GSH contents than those observed in WI-38/Vector cells after exposure to tetrandrine.	ros	42-45	peptidylprolyl isomerase G	Homo sapiens	6-9
32195756-6	2020	Suppression of GPR35 protects heart from MI injury in mice through reduction of ROS activity and mitochondria-dependent apoptosis.	ros	80-83	G protein-coupled receptor 35	Mus musculus	15-20
32378287-8	2020	In addition, the inhibition of ROS by NAC partially reversed the damage of TAK1 in vitro.	ros	31-34	NLR family, pyrin domain containing 1A	Mus musculus	38-41
32376151-12	2020	Pretreatment with the antioxidant NAC reduced IMQ-induced ROS production and attenuated IMQ-induced mitochondrial fission and mitophagy in skin cancer cells.	ros	58-61	X-linked Kx blood group	Homo sapiens	34-37
27246978-5	2016	These results suggest that the high level of ROS is needed for tumorigenesis and progression in tumors with the low HSP60 expression and HSP60 is a potential diagnostic biomarker as well as a therapeutic target in ccRCC.	ros	45-48	heat shock protein 1 (chaperonin)	Mus musculus	116-121
32566078-15	2020	Our findings demonstrated a novel mechanism by which WXG attenuated oxidative stress and mitochondrial dysfunction of H9c2 cells induced by H/R stimulation via inhibitory regulation of PKC-delta/NOX2/ROS signaling.	ros	200-203	cytochrome b-245 beta chain	Rattus norvegicus	195-199
32508629-10	2020	Taken together, the results reveal that TLB effectively protects against Abeta25-35-induced neuronal cell death via activating ROS/p38/caspase 3-dependent pathway.	ros	127-130	caspase 3	Mus musculus	135-144
27203742-1	2016	Glutaredoxin 3 (GLRX3) is antioxidant enzyme, maintaining a low level of ROS, thus contributing to the survival and metastasis of several types of cancer.	ros	73-76	glutaredoxin 3	Homo sapiens	0-14
27203742-1	2016	Glutaredoxin 3 (GLRX3) is antioxidant enzyme, maintaining a low level of ROS, thus contributing to the survival and metastasis of several types of cancer.	ros	73-76	glutaredoxin 3	Homo sapiens	16-21
19719386-5	2010	In this review, we summarize and highlight current experimental evidence supporting the idea that cross-talk between Ca(2+) and ROS/RNS may represent a well-integrated signaling network in vascular smooth muscle.	ros	128-131	FAM20C golgi associated secretory pathway kinase	Homo sapiens	132-135
27203742-6	2016	Furthermore, stabilization of GLRX3 was positively related to with epidermal growth factor receptor (EGFR) expression and negatively with ROS generation.	ros	138-141	glutaredoxin 3	Homo sapiens	30-35
32431608-9	2020	Infusion of 5-10-sP (n = 5) and HSP10 (n = 5) into isolated hearts before I/R improved mitochondrial ADP-stimulated respiration, ATP production and prevented mitochondrial ROS formation compared to the I/R group (n = 5); this effect was abrogated by 5HD and chelerythrine.	ros	172-175	heat shock protein family E (Hsp10) member 1	Rattus norvegicus	32-37
27297735-4	2016	Excessive post-translational oxidation of protein disulfide isomerase (PDI), intra-ER ROS accumulation and folding capacitance alteration were also observed in HFD-BI-1 KO mice.	ros	86-89	transmembrane BAX inhibitor motif containing 6	Mus musculus	164-168
32269896-7	2020	The extract reduced ROS in these cells, which consequently decreased the degree of autophagic cell death by restoring expressions of mTOR, survivin and BECN1 to their respective normal levels.	ros	20-23	beclin 1	Homo sapiens	152-157
20213926-1	2010	Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca(2+) sensor (NCS) that regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in photoreceptors.	ros	152-155	guanylate cyclase activator 2A	Homo sapiens	0-38
20213926-1	2010	Guanylate cyclase activating protein 1 (GCAP1) is a neuronal Ca(2+) sensor (NCS) that regulates the activation of rod outer segment guanylate cyclases (ROS-GCs) in photoreceptors.	ros	152-155	guanylate cyclase activator 2A	Homo sapiens	40-45
27297735-7	2016	Our results suggest that BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation, likely through regulation of ER stress and ROS accumulation.	ros	150-153	transmembrane BAX inhibitor motif containing 6	Mus musculus	25-29
27297735-7	2016	Our results suggest that BI-1-mediated enhancement of ApoB secretion regulates hepatic lipid accumulation, likely through regulation of ER stress and ROS accumulation.	ros	150-153	apolipoprotein B	Mus musculus	54-58
31309446-8	2020	Furthermore, the ROS levels in the testes obviously increased after Zn-deficient mice were stimulated with CCl4, whereas reduced glutathione (GSH) and glutathione peroxidase (GSH-Px) showed reduced activities.	ros	17-20	chemokine (C-C motif) ligand 4	Mus musculus	107-111
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	ros	126-129	basigin (Ok blood group)	Homo sapiens	70-77
31982503-12	2020	Therefore, it can be speculated that ROS- mediated ER-stress induced by ZEA activates AMPK via Ca2+-CaMKKbeta leading to autophagy in TM4 cells.	ros	37-40	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	100-109
20133633-8	2010	PI3Kgamma, but not class IA PI3Ks, was negatively regulated by gradually accumulated ROS in apoptotic neutrophils, which suppressed PI3Kgamma activity by inhibiting an actin-mediated positive feedback loop.	ros	85-88	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	0-9
20133633-8	2010	PI3Kgamma, but not class IA PI3Ks, was negatively regulated by gradually accumulated ROS in apoptotic neutrophils, which suppressed PI3Kgamma activity by inhibiting an actin-mediated positive feedback loop.	ros	85-88	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Homo sapiens	132-141
27429847-6	2016	Moreover, our findings suggested that the modulatory effects of PG on EMMPRIN were due, at least in part, to regulation of an ROS-miR-27a/ZBTB10-Sp1 transcription factor pathway.	ros	126-129	zinc finger and BTB domain containing 10	Homo sapiens	138-144
27005319-11	2016	FoxO1 silencing by siRNA abolished the protective effects of apelin-13 against hypoxia-induced apoptosis and mitochondrial ROS generation.	ros	123-126	forkhead box O1	Mus musculus	0-5
20018182-4	2010	DBP-5 caused massive ROS accumulation and GSH decrease, which lead to MMP disruption, caspase activation and finally induced cell apoptosis.	ros	21-24	DEAD-box helicase 19B	Homo sapiens	0-5
32351616-11	2020	Mechanistically, DHA induced intracellular ROS generation and autophagy in Eca109 cells, while blocking ROS by an antioxidant NAC obviously inhibited autophagy.	ros	104-107	X-linked Kx blood group	Homo sapiens	126-129
27173006-0	2016	SARS coronavirus papain-like protease induces Egr-1-dependent up-regulation of TGF-beta1 via ROS/p38 MAPK/STAT3 pathway.	ros	93-96	early growth response 1	Homo sapiens	46-51
32351616-12	2020	Furthermore, we found that telomere shelterin component TRF2 was down-regulated in Eca109 cells exposed to DHA through autophagy-dependent degradation, which could be rescued after autophagy was blocked by ROS inhibition.	ros	206-209	telomeric repeat binding factor 2	Homo sapiens	56-60
19720122-0	2009	Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway.	ros	89-92	Fas ligand	Homo sapiens	33-37
19720122-9	2009	Taken together, our data indicate that Fas/FasL upregulation in AA-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas-mediated apoptotoic mechanism is involved in AA-induced cell death.	ros	108-111	Fas ligand	Homo sapiens	43-47
27173006-7	2016	Furthermore, the inhibitors for ROS (YCG063), p38 MAPK (SB203580), and STAT3 (Stattic) revealed ROS/p38 MAPK/STAT3 pathway involving in Egr-1 dependent activation of TGF-beta1 promoter induced by PLpro.	ros	32-35	early growth response 1	Homo sapiens	136-141
27173006-7	2016	Furthermore, the inhibitors for ROS (YCG063), p38 MAPK (SB203580), and STAT3 (Stattic) revealed ROS/p38 MAPK/STAT3 pathway involving in Egr-1 dependent activation of TGF-beta1 promoter induced by PLpro.	ros	96-99	early growth response 1	Homo sapiens	136-141
31346611-4	2020	METHODS AND RESULTS: In primary mouse AFs, we found that calcineurin-dependent dephosphorylation of Drp1 induced mitochondrial fission and regulated mitochondrial ROS production, which stimulated AF proliferation, migration, and phenotypic switching in AngII-treated AFs.	ros	163-166	collapsin response mediator protein 1	Mus musculus	100-104
27173006-9	2016	The results revealed that SARS-CoV PLpro significantly triggered Egr-1 dependent activation of TGF-beta1 promoter via ROS/p38 MAPK/STAT3 pathway, correlating with up-regulation of pro-fibrotic responses in vitro and in vivo.	ros	118-121	early growth response 1	Mus musculus	65-70
27027430-0	2016	Differentiation inducing factor 3 mediates its anti-leukemic effect through ROS-dependent DRP1-mediated mitochondrial fission and induction of caspase-independent cell death.	ros	76-79	dynamin 1 like	Homo sapiens	90-94
32172136-2	2020	Mitogen activated Protein kinase (MAPK) pathway is known to mediate photoaging by controlling the level of ROS and initiating detoxification.	ros	107-110	Mitogen-activated protein kinase 15	Caenorhabditis elegans	0-32
32172136-2	2020	Mitogen activated Protein kinase (MAPK) pathway is known to mediate photoaging by controlling the level of ROS and initiating detoxification.	ros	107-110	Mitogen-activated protein kinase 15	Caenorhabditis elegans	34-38
27041464-8	2016	Furthermore, ROS production and the expression of p47 (a key subunit of NADPH oxidase complexes) were increased in a time-dependent manner; the expression of fibronectin, alpha-SMA and TGF-beta were upregulated.	ros	13-16	fibronectin 1	Mus musculus	158-169
19806015-0	2009	Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels.	ros	77-80	H3 histone pseudogene 16	Homo sapiens	9-12
26895787-3	2016	Here, we show that deletion of HXK2 causes hypersensitivity to H2O2 and that addition of this well-known apoptotic stimulus to hxk2Delta cells causes an increase in the level ROS, apoptosis and mitochondrial membrane potential.	ros	175-178	hexokinase 2	Saccharomyces cerevisiae S288C	31-35
19696743-0	2009	A non-redundant role for MKP5 in limiting ROS production and preventing LPS-induced vascular injury.	ros	42-45	dual specificity phosphatase 10	Mus musculus	25-29
31887498-8	2020	When the cells were treated with NAC, ROS induced by CB decreased, SOD and CAT activities of CB-treated 16HBE cells were increased.	ros	38-41	X-linked Kx blood group	Homo sapiens	33-36
31830513-9	2020	Additionally, SIRT1 activation significantly suppressed the ROS generation, leading to increase mitochondrial membrane potential and COX IV expression.	ros	60-63	sirtuin 1	Sus scrofa	14-19
31830513-11	2020	Collectively, these findings indicated that autophagy/mitophagy elevation caused by SIRT1/PGC-1alpha pathway activation might be a protective mechanism to increase tight junction integrity against oxidative stress-mediated ROS production in IPEC-1 cells.	ros	223-226	sirtuin 1	Sus scrofa	84-89
26895787-3	2016	Here, we show that deletion of HXK2 causes hypersensitivity to H2O2 and that addition of this well-known apoptotic stimulus to hxk2Delta cells causes an increase in the level ROS, apoptosis and mitochondrial membrane potential.	ros	175-178	hexokinase 2	Saccharomyces cerevisiae S288C	127-131
26895787-4	2016	We also show that deletion of AIF1 in hxk2Delta cells enhances survival after induction of apoptosis with both H2O2 and acetic acid, rescues the reduction of both growth rate and cell size, abrogates both H2O2 and acetic acid-induced ROS accumulation and decreases cell death, suggesting that Aif1 might be involved in both H2O2 and acetic acid-induced cell death in hxk2Delta cells.	ros	234-237	hexokinase 2	Saccharomyces cerevisiae S288C	38-42
27124120-2	2016	In the present study, we tested the hypothesis that CAV-1 improves dyslipidemia, inhibits cyclophilin A (CypA)- mediated ROS production, prevents mitochondrial compensatory action and attenuates oxidative stress responses in cholesterol-induced hypercholesterolemia.	ros	121-124	caveolin-1	Oryctolagus cuniculus	52-57
31975555-4	2020	First, we demonstrated that MsrA overexpression attenuated ROS level and inflammation in HepG2 cells.	ros	59-62	methionine sulfoxide reductase A	Homo sapiens	28-32
19539751-7	2009	Additionally, the L-012 signal was abolished in mice with a mutation in the Ncf1 gene, encoding a protein in the NADPH oxidase complex 2, which generates ROS/RNS during inflammation.	ros	154-157	neutrophil cytosolic factor 1	Mus musculus	76-80
27124120-8	2016	We concluded that CAV-1 plays a critical role in inhibiting CypA-mediated ROS production, improving dyslipidemia, maintaining mitochondrial function, and suppressing oxidative stress responses that are vital for cell survival in hypercholesterol-affected renal organs.	ros	74-77	caveolin-1	Oryctolagus cuniculus	18-23
26967755-5	2016	When activated by peroxisomal ROS, ATM signals to TSC to repress mTORC1 signaling and increase autophagic flux in cells, and also phosphorylates the peroxisomal protein PEX 5 to target peroxisomes for selective autophagy (pexophagy), providing a mechanism for regulation of peroxisomal homeostasis using ROS as a rheostat.	ros	30-33	ATM serine/threonine kinase	Homo sapiens	35-38
19576285-11	2009	Correlating the AbFas ligand transcriptional up-regulation against bacteria, virus and LPS with the biological activity of its recombinant protein, we could suggest that the abalone Fas ligand may control microbial infection by inducing O(2-), H(2)O(2) and other ROS.	ros	263-266	Fas ligand	Homo sapiens	18-28
31825809-0	2020	Bioenergetic consequences from xenotopic expression of a tunicate AOX in mouse mitochondria: Switch from RET and ROS to FET.	ros	113-116	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	66-69
26967755-5	2016	When activated by peroxisomal ROS, ATM signals to TSC to repress mTORC1 signaling and increase autophagic flux in cells, and also phosphorylates the peroxisomal protein PEX 5 to target peroxisomes for selective autophagy (pexophagy), providing a mechanism for regulation of peroxisomal homeostasis using ROS as a rheostat.	ros	304-307	ATM serine/threonine kinase	Homo sapiens	35-38
31825809-7	2020	AOX enhances the forward electron transport (FET) from cII thereby decreasing reverse electron transport (RET) and ROS specifically when non-phosphorylating.	ros	115-118	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	0-3
19652361-6	2009	In primary cultures of cardiomyocytes, Sirt3 blocked cardiac hypertrophy by activating the forkhead box O3a-dependent (Foxo3a-dependent), antioxidant-encoding genes manganese superoxide dismutase (MnSOD) and catalase (Cat), thereby decreasing cellular levels of ROS.	ros	262-265	sirtuin 3	Mus musculus	39-44
26891815-3	2016	STE was also found to induce significant amount ROS generation in SCC-25 cells.	ros	48-51	sulfotransferase family 1E member 1	Homo sapiens	0-3
19465002-0	2009	Gelsolin, but not its cleavage, is required for TNF-induced ROS generation and apoptosis in MCF-7 cells.	ros	60-63	gelsolin	Homo sapiens	0-8
19465002-6	2009	Furthermore, TNF-induced ROS production in Gel(mut) cells was significantly decreased, demonstrating that gelsolin-mediated ROS generation plays a crucial role in TNF-induced apoptosis in MCF-7 cells.	ros	25-28	gelsolin	Homo sapiens	106-114
19465002-6	2009	Furthermore, TNF-induced ROS production in Gel(mut) cells was significantly decreased, demonstrating that gelsolin-mediated ROS generation plays a crucial role in TNF-induced apoptosis in MCF-7 cells.	ros	124-127	gelsolin	Homo sapiens	106-114
19465002-8	2009	Our study thus provides genetic evidence linking gelsolin-mediated ROS production to TNF-induced cell death.	ros	67-70	gelsolin	Homo sapiens	49-57
31557070-4	2020	The results demonstrated that triptolide treatment caused an increase in apoptotic cell death, mitochondrial depolarization, ROS overproduction, a decrease in ATP production, and mitochondrial fragmentation which in turn is associated with the activation of Drp1 fission protein.	ros	125-128	utrophin	Homo sapiens	258-262
31755616-11	2020	Moreover, KCs from CCL4-induced mice showed increased ROS production, mitophagy activation and TGF-beta1 secretion.	ros	54-57	chemokine (C-C motif) ligand 4	Mus musculus	19-23
31560934-5	2019	Mechanistically, activated MLKL targets mitochondria and triggers excessive generation of mitochondrial superoxide, which promotes AIF translocation into nucleus via causing mitochondrial depolarization and aggravates gamma-H2AX formation via improving intracellular accumulation of ROS.	ros	283-286	apoptosis inducing factor mitochondria associated 1	Homo sapiens	131-134
26891815-6	2016	In all cases morin provided cytoprotection to STE challenged SCC-25 cells by augmenting STE induced ROS-dependent cytotoxic autophagy.	ros	100-103	sulfotransferase family 1E member 1	Homo sapiens	88-91
26860957-7	2016	Pretreatment of antioxidants caused decrease in the levels of ROS/RNS leads to an increase in the levels of antioxidants, decrease in biomolecules damage, alterations in Akt, ERK1/2, tuberin, upregulation of OGG1, and decrease in 8-OHdG accumulations in DNA.	ros	62-65	TSC complex subunit 2	Mus musculus	183-190
26804764-0	2016	4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.	ros	89-92	mitogen-activated protein kinase 8	Rattus norvegicus	120-123
31844091-6	2019	Furthermore, mutant Cx50 leads to decreased ROS scavenging by inhibiting G6PD expression and thus induces cell apoptosis via aberrant activation of the unfolded protein response (UPR).	ros	44-47	gap junction protein alpha 8	Homo sapiens	20-24
31844091-6	2019	Furthermore, mutant Cx50 leads to decreased ROS scavenging by inhibiting G6PD expression and thus induces cell apoptosis via aberrant activation of the unfolded protein response (UPR).	ros	44-47	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
19240275-6	2009	Furthermore, our results suggest that DC apoptosis was triggered via caspase activation, and it was ROS dependent with GD3 ganglioside, suggesting that GM3 and GD3 induced apoptosis through different mechanisms.	ros	100-103	GRDX	Homo sapiens	119-122
26804764-11	2016	Collectively, our findings provide the first evidence that NP promotes apoptosis, autophagy and necrosis simultaneously in SCs and that this process may involve ROS-dependent JNK- and Akt/AMPK/mTOR pathways.	ros	161-164	mitogen-activated protein kinase 8	Rattus norvegicus	175-179
19240275-6	2009	Furthermore, our results suggest that DC apoptosis was triggered via caspase activation, and it was ROS dependent with GD3 ganglioside, suggesting that GM3 and GD3 induced apoptosis through different mechanisms.	ros	100-103	GRDX	Homo sapiens	160-163
26695589-9	2016	Finally, all three ER antagonists attenuated ethanol-evoked elevation in myocardial ROS, but this effect was most notable with ERalpha blockade.	ros	84-87	estrogen receptor 1	Rattus norvegicus	19-21
26707141-11	2016	Physcion markedly increased ROS production and phosphorylation of AMPK and GSK3beta in the cells, whereas the AMPK inhibitor compound C or the ROS inhibitor NAC abolished the inhibition of physcion on metastatic behaviors.	ros	143-146	synuclein alpha	Homo sapiens	157-160
19234337-12	2009	Studies using human ECs demonstrated that TNF-alpha-induced CCL2 production was also inhibited by the NAD(P)H oxidase inhibitor DPI, the antioxidant N-acetyl-L-cysteine, or the superoxide scavenger Tiron, further indicating that inhibition occurs through the NAD(P)H/ROS pathway.	ros	267-270	C-C motif chemokine ligand 2	Homo sapiens	60-64
26707143-0	2016	Curcumin enhances the antitumor effect of ABT-737 via activation of the ROS-ASK1-JNK pathway in hepatocellular carcinoma cells.	ros	72-75	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	76-80
26707143-8	2016	In addition, the sustained activation of the ROS-ASK1-c-Jun N-terminal kinase pathway may be an important mediator of the synergistic effect of curcumin and ABT-737.	ros	45-48	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	49-53
19416715-7	2009	It also rescued the locomotor defect and excess mitochondrial ROS production of flies mutated in dj-1beta, a Drosophila homolog of the human Parkinson"s disease gene DJ1.	ros	62-65	dj-1beta	Drosophila melanogaster	97-105
26242901-5	2016	Understanding the molecular link between ROS/RNS-mediated apoptosis and DNA damage-involved chromosome instability is critical for the development of more efficacious therapeutic strategies for selective killing of diverse cancer cells.	ros	41-44	FAM20C golgi associated secretory pathway kinase	Homo sapiens	45-48
18996220-5	2009	ROS-mediated DNA damage as measured by the presence of 8-OHdG DNA-adducts in their nuclei, IkappaB phosphorylation, NF-kappaB activation and increases in c-Myc and HO-1 protein levels were also observed, suggesting that these factors play a relevant role in the arsenite induced MCF-7 cell recruitment into the S-phase of the cell cycle and cell proliferation observed.	ros	0-3	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	154-159
18996220-5	2009	ROS-mediated DNA damage as measured by the presence of 8-OHdG DNA-adducts in their nuclei, IkappaB phosphorylation, NF-kappaB activation and increases in c-Myc and HO-1 protein levels were also observed, suggesting that these factors play a relevant role in the arsenite induced MCF-7 cell recruitment into the S-phase of the cell cycle and cell proliferation observed.	ros	0-3	heme oxygenase 1	Homo sapiens	164-168
31885824-0	2019	ALCAT1 Overexpression Affects Supercomplex Formation and Increases ROS in Respiring Mitochondria.	ros	67-70	lysocardiolipin acyltransferase 1	Homo sapiens	0-6
31885824-10	2019	Artificially induced ALCAT1 overexpression reduced supercomplex formation, further promoted ROS production, and prevented upregulation of coupled respiration.	ros	92-95	lysocardiolipin acyltransferase 1	Homo sapiens	21-27
30945565-2	2019	It has been reported that Pink1-Parkin-mediated mitochondrial autophagy could effectively remove damaged mitochondria and excess ROS to ensure the stability of intracellular mitochondria.	ros	129-132	PTEN induced kinase 1	Rattus norvegicus	26-31
19074984-6	2009	AngII increased mitochondrial ROS and decreased mitochondrial membrane potential, and these effects of AngII were significantly suppressed by blockade of either AT1R or AT2R.	ros	30-33	angiotensin II, type I receptor-associated protein	Mus musculus	161-165
27642598-10	2016	The elevated ROS production observed after short-term application of inhibitor MI-441 could be correlated with lowered hepcidin expression.	ros	13-16	hepcidin antimicrobial peptide	Homo sapiens	119-127
31300985-9	2019	FNTA-siRNA and EHop inhibited glucose-induced activation of Rac1-Nox2-ROS signaling.	ros	70-73	farnesyltransferase, CAAX box, alpha	Homo sapiens	0-4
31300985-9	2019	FNTA-siRNA and EHop inhibited glucose-induced activation of Rac1-Nox2-ROS signaling.	ros	70-73	Rac family small GTPase 1	Homo sapiens	60-64
31300985-9	2019	FNTA-siRNA and EHop inhibited glucose-induced activation of Rac1-Nox2-ROS signaling.	ros	70-73	cytochrome b-245 beta chain	Homo sapiens	65-69
31300985-12	2019	In diabetes, Rac1 prenylation and its interactions with Vav2 contribute to Nox2-ROS-mitochondrial damage, and the pharmacological inhibitors to attenuate Rac1 interactions with its regulators could have the potential to halt/inhibit the development of diabetic retinopathy.	ros	80-83	Rac family small GTPase 1	Homo sapiens	13-17
31300985-12	2019	In diabetes, Rac1 prenylation and its interactions with Vav2 contribute to Nox2-ROS-mitochondrial damage, and the pharmacological inhibitors to attenuate Rac1 interactions with its regulators could have the potential to halt/inhibit the development of diabetic retinopathy.	ros	80-83	cytochrome b-245 beta chain	Homo sapiens	75-79
31300985-15	2019	Active Rac1 helps in the assembly of Nox2 holoenzyme, and Nox2 activation increases cytosolic ROS production, damaging the mitochondria.	ros	94-97	cytochrome b-245 beta chain	Homo sapiens	58-62
31558316-7	2019	Pretreated with NAC, an antioxidant, could inhibit ROS production and PARP-1 cleavage as well as prevent cell apoptotic death induced by combination therapy with TRAIL and ipatasertib.	ros	51-54	X-linked Kx blood group	Homo sapiens	16-19
18801380-0	2009	Effects of cyclic strain on endothelial cell apoptosis and tubulogenesis are dependent on ROS production via NAD(P)H subunit p22phox.	ros	90-93	cytochrome b-245 alpha chain	Homo sapiens	125-132
18801380-11	2009	ROS production was increasingly stimulated progressively by strain via the p22phox pathway.	ros	0-3	cytochrome b-245 alpha chain	Homo sapiens	75-82
26606859-10	2016	Pretreatment of INS-1 with LiCl inhibited dexamethasone induced ROS generation and INS-1 apoptosis.	ros	64-67	insulin 1	Rattus norvegicus	16-21
19267992-2	2009	It inhibits the activity of thioredoxin, thus contributing cellular ROS generation.	ros	68-71	thioredoxin	Homo sapiens	28-39
19009558-0	2009	Upregulation of Fas and FasL in Taiwan cobra phospholipase A2-treated human neuroblastoma SK-N-SH cells through ROS- and Ca2+-mediated p38 MAPK activation.	ros	112-115	Fas ligand	Homo sapiens	24-28
19009558-4	2009	N-Acetylcysteine (ROS scavenger) and BAPTA-AM (Ca(2+) chelator) abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored phosphorylation of ERK.	ros	18-21	Fas ligand	Homo sapiens	122-126
31301273-8	2019	The obtained data exhibited that inhibition of miR-137 or up-regulation of OXR1 ameliorated PD-induced oxidative stress injury, reduced pole-climbing time, but increased score for traction test as well as promoted viability and decreased apoptosis of neurons in PD model, accompanied with decreased MDA content and ROS levels, and increased SOD levels.	ros	315-318	oxidation resistance 1	Mus musculus	75-79
31229705-10	2019	In addition, inhibiting JNK and ATM/ATR signaling pathways partially rescued the decrease in cell viability, indicating that abamectin-induced ROS overproduction and DNA damage might finally lead to cytotoxicity through JNK and ATM/ATR signaling pathways.	ros	143-146	mitogen-activated protein kinase 8	Mus musculus	220-223
31330223-0	2019	Sigma-1 receptor activation ameliorates LPS-induced NO production and ROS formation through the Nrf2/HO-1 signaling pathway in cultured astrocytes.	ros	70-73	sigma non-opioid intracellular receptor 1	Homo sapiens	0-16
19009558-8	2009	Taken together, our results indicate that PLA(2)-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca(2+)- and ROS-evoked p38 MAPK activation, and suggest that non-catalytic PLA(2) plays a role for the signaling pathway.	ros	157-160	Fas ligand	Homo sapiens	117-121
26511233-8	2016	This leads to the activation of calcineurin B, independent of NFAT involvement, which in coordination with ROS induces the activation of JNK of the MAPK signalling.	ros	107-110	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	32-45
19137062-0	2009	Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cells.	ros	53-56	catenin beta 1	Homo sapiens	31-43
19018768-0	2008	Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT.	ros	100-103	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	134-138
31601785-5	2019	Finally, we also found that the elevated ROS was in line with enhancing the phosphorylation of Bcl-2 and beclin1 which contributed to 1, 4-BQ-induced autophagy and apoptosis.	ros	41-44	beclin 1	Homo sapiens	105-112
31301277-9	2019	The ROS scavenger NAC markedly diminished G2/M arrest, apoptosis, autophagy and activation of MAPK pathways induced by Rg5.	ros	4-7	X-linked Kx blood group	Homo sapiens	18-21
31265755-7	2019	In contrast, in vitro stimulation of trophoblasts with rHMGB1 caused activation of NADPH oxidase and increased the production of ROS, which contributes to high bacterial burden within trophoblasts or placenta.	ros	129-132	high mobility group box 1	Rattus norvegicus	55-61
26681956-2	2016	To examine the mechanisms by which this occurs, we hypothesized that an increase in heme oxygenase 1, a potent antioxidant gene, will decrease uric acid levels and adipocyte dysfunction via suppression of ROS and xanthine oxidase (XO) levels.	ros	205-208	heme oxygenase 1	Homo sapiens	84-100
31254567-0	2019	ATPR-induced differentiation and G0/G1 phase arrest in acute promyelocytic leukemia by repressing EBP50/NCF1 complex to promote the production of ROS.	ros	146-149	neutrophil cytosolic factor 1	Homo sapiens	104-108
31254567-9	2019	Interestingly, the reduction of EBP50 contributed to ROS release by modulating the subcellular localization of NCF1.	ros	53-56	neutrophil cytosolic factor 1	Homo sapiens	111-115
18847221-1	2008	The transient changes of the tryptophan fluorescence of bovine rhodopsin in ROS membranes were followed in time from 1 micros to 10 s after flash excitation of the photoreceptor.	ros	76-79	rhodopsin	Bos taurus	63-72
26862579-4	2016	Ang II also stimulates ROS production in VSMC via p47 (phox) , a NOX2 subunit.	ros	23-26	pleckstrin	Homo sapiens	50-53
26640170-1	2015	Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury.	ros	89-92	coagulation factor II (thrombin) receptor	Mus musculus	21-52
18769232-3	2008	RECENT FINDINGS: Heme oxygenase-1 has been shown to be protective against atherosclerosis via decreasing ROS generation and proinflammatory cytokine production resulting in diminished lipid uptake and foam cell formation.	ros	105-108	heme oxygenase 1	Homo sapiens	17-33
31612074-7	2019	In addition, pretreatment of EX-527, a selective SIRT1 inhibitor, could block the increased mitochondrial mass and decreased ROS production induced by salidroside in 50PD cells, resulting in an accelerated cellular senescence.	ros	125-128	sirtuin 1	Homo sapiens	49-54
31487955-4	2019	These data suggest that ROS/RNS could be essential to modulate the role of catalase in maintaining basic cellular peroxisomal functions during pepper fruit ripening when nitro-oxidative stress occurs.	ros	24-27	catalase	Capsicum annuum	75-83
26640170-1	2015	Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury.	ros	89-92	coagulation factor II (thrombin) receptor	Mus musculus	54-58
31176117-6	2019	Further the results demonstrated that ROS generated by cuboid and rod shaped nanopolymorphs activated the pro-angiogenic factors namely VE-cadherin, HIF 1alpha, VEGF and VEGFR-2 to facilitate the angiogenic process.	ros	38-41	kinase insert domain receptor	Homo sapiens	170-177
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	36-39	H3 histone pseudogene 16	Homo sapiens	65-68
31429763-7	2019	Overexpression of NFAT5 activates NLRP3-inflammasome and increases the secretion of IL-1beta in ECs partly via ROS.	ros	111-114	nuclear factor of activated T cells 5	Mus musculus	18-23
18756095-6	2008	These findings led us to suggest the possibility that Gpx3, known as a redox sensor and ROS scavenger, has another functional role by interacting with several proteins with various cellular functions.	ros	88-91	peroxiredoxin HYR1	Saccharomyces cerevisiae S288C	54-58
20731933-7	2008	(3)incubated NAC with selenite could significantly inhibit the ROS but increase the ROS treated by NAC with MSA.	ros	63-66	synuclein alpha	Homo sapiens	13-16
20731933-7	2008	(3)incubated NAC with selenite could significantly inhibit the ROS but increase the ROS treated by NAC with MSA.	ros	84-87	synuclein alpha	Homo sapiens	13-16
31485193-0	2019	RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose.	ros	50-53	receptor interacting serine/threonine kinase 2	Homo sapiens	0-5
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	36-39	synuclein alpha	Homo sapiens	158-161
31485193-1	2019	Background: Hyperglycemia plays a vital role in diabetic nephropathy (DN); autophagy and its potential upregulator receptor-interacting protein kinase 2 (RIPK2) are associated with ROS, which play a potential role in regulating NLRP3, and may be involved in inflammation in DN.	ros	181-184	receptor interacting serine/threonine kinase 2	Homo sapiens	115-152
31485193-1	2019	Background: Hyperglycemia plays a vital role in diabetic nephropathy (DN); autophagy and its potential upregulator receptor-interacting protein kinase 2 (RIPK2) are associated with ROS, which play a potential role in regulating NLRP3, and may be involved in inflammation in DN.	ros	181-184	receptor interacting serine/threonine kinase 2	Homo sapiens	154-159
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	36-39	H3 histone pseudogene 16	Homo sapiens	196-199
31485193-10	2019	RIPK2 regulates ROS-NLRP3 inflammasome signaling through autophagy and may be involved in the pathogenesis of DN.	ros	16-19	receptor interacting serine/threonine kinase 2	Homo sapiens	0-5
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	151-154	H3 histone pseudogene 16	Homo sapiens	65-68
20731933-7	2008	(3)incubated NAC with selenite could significantly inhibit the ROS but increase the ROS treated by NAC with MSA.	ros	84-87	synuclein alpha	Homo sapiens	99-102
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	151-154	synuclein alpha	Homo sapiens	158-161
26432358-5	2015	The involvement of estrogen induced ROS in the p38 MAPK mediated p21 expression and cell growth arrest was established by observing that scavenging of ROS by NAC abrogated p38 MAPK activation and p21 expression during hypoxia.	ros	151-154	H3 histone pseudogene 16	Homo sapiens	196-199
25975898-3	2015	The regulation of ROS/RNS is largely attended by peroxiredoxins (Prdxs) and their main reductants, thioredoxins (Trxs).	ros	18-21	peroxiredoxin 1	Mus musculus	49-63
18563748-6	2008	Most of those proteins are correlated with ROS-elicited responses, which were further validated by Western blotting analysis, induction of p53 pathway and antioxidative treatment.	ros	43-46	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	139-142
31398912-7	2019	In addition, 5-7HP inhibited PM-induced ROS generation and then downregulated ROS-mediated COX-2 and MMP9 production and AQP-3 consumption by inhibiting the phosphorylation of MAPKs.	ros	78-81	matrix metallopeptidase 9	Homo sapiens	101-105
31160087-7	2019	Lentivirus mediated A20 overexpression increased ROS generation and enhanced erastin-induced ferroptosis, whereas A20 knockdown inhibited erastin-induced ferroptosis.	ros	49-52	immunoglobulin kappa variable 1-27	Homo sapiens	20-23
31337986-0	2019	YAP promotes multi-drug resistance and inhibits autophagy-related cell death in hepatocellular carcinoma via the RAC1-ROS-mTOR pathway.	ros	118-121	Rac family small GTPase 1	Homo sapiens	113-117
31337986-9	2019	Mechanistically, YAP silencing significantly enhanced autophagic flux by increasing RAC1-driven ROS, which contributed to the inactivation of mTOR in HCC cells.	ros	96-99	Rac family small GTPase 1	Homo sapiens	84-88
31337986-11	2019	Conclusion: Our findings suggested that YAP upregulation endowed HCC cells with multi-drug resistance via the RAC1-ROS-mTOR pathway, resulting in the repression of autophagy-related cell death.	ros	115-118	Rac family small GTPase 1	Homo sapiens	110-114
18068923-5	2008	Oxidative stress is a potent trigger for mobilization of intracellular free Zn(2+) ([Zn(2+)](i)) and we therefore evaluated ROS-driven [Zn(2+)](i) rises in neurons obtained from triple transgenic AD mice (3xTg-AD) that express mutant APP, PS1 and tau.	ros	124-127	presenilin 1	Mus musculus	239-242
26567598-0	2015	ROS, MAPK/ERK and PKC play distinct roles in EGF-stimulated human corneal cell proliferation and migration.	ros	0-3	epidermal growth factor	Homo sapiens	45-48
18068923-5	2008	Oxidative stress is a potent trigger for mobilization of intracellular free Zn(2+) ([Zn(2+)](i)) and we therefore evaluated ROS-driven [Zn(2+)](i) rises in neurons obtained from triple transgenic AD mice (3xTg-AD) that express mutant APP, PS1 and tau.	ros	124-127	microtubule associated protein tau	Homo sapiens	247-250
18262205-0	2008	YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1.	ros	113-116	mitogen-activated protein kinase 8	Rattus norvegicus	129-132
31410206-8	2019	The miR-150-mediated autophagy defect induced ER stress and increased cellular ROS levels and DNA damage response, and promoted NSCLC cell proliferation and tumor growth.	ros	79-82	microRNA 150	Homo sapiens	4-11
26567598-9	2015	Interestingly, the promotion effect of EGF on HCE cell proliferation is mainly mediated by activated ROS signaling under disease condition.	ros	101-104	epidermal growth factor	Homo sapiens	39-42
18064039-4	2008	In addition, the data reveal that gzmB(+)CTL independently induce pro-apoptotic processes either via caspase-3/-7, leading to plasma membrane perturbance and ROS production or via Bid/Bak/Bax, resulting in cytochrome c release and that both pathways elicit loss of DeltaPsi(m).	ros	158-161	granzyme B	Homo sapiens	34-38
26567598-10	2015	However, the EGF function is mediated by ROS and MAPK/ERK pathway in EGF-treated corneal epithelial cells in physiology status, in which ROS and MAPK/ERK pathway have no mutual influence on the other signaling pathway in EGF-stimulated corneal epithelial cells.	ros	41-44	epidermal growth factor	Homo sapiens	13-16
26567598-10	2015	However, the EGF function is mediated by ROS and MAPK/ERK pathway in EGF-treated corneal epithelial cells in physiology status, in which ROS and MAPK/ERK pathway have no mutual influence on the other signaling pathway in EGF-stimulated corneal epithelial cells.	ros	41-44	epidermal growth factor	Homo sapiens	69-72
18164269-1	2008	The mitochondrial form of thioredoxin, thioredoxin 2 (Txn2), plays an important role in redox control and protection against ROS-induced mitochondrial damage.	ros	125-128	thioredoxin 2	Mus musculus	39-52
31303967-0	2019	Correction: Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-kappaB.	ros	110-113	euchromatic histone lysine methyltransferase 2	Homo sapiens	26-31
31303967-0	2019	Correction: Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-kappaB.	ros	110-113	euchromatic histone lysine methyltransferase 2	Homo sapiens	32-35
31303967-0	2019	Correction: Inhibition of EHMT2/G9a epigenetically increases the transcription of Beclin-1 via an increase in ROS and activation of NF-kappaB.	ros	110-113	beclin 1	Homo sapiens	82-90
26567598-10	2015	However, the EGF function is mediated by ROS and MAPK/ERK pathway in EGF-treated corneal epithelial cells in physiology status, in which ROS and MAPK/ERK pathway have no mutual influence on the other signaling pathway in EGF-stimulated corneal epithelial cells.	ros	41-44	epidermal growth factor	Homo sapiens	69-72
26567598-10	2015	However, the EGF function is mediated by ROS and MAPK/ERK pathway in EGF-treated corneal epithelial cells in physiology status, in which ROS and MAPK/ERK pathway have no mutual influence on the other signaling pathway in EGF-stimulated corneal epithelial cells.	ros	137-140	epidermal growth factor	Homo sapiens	13-16
31177114-4	2019	RESULTS: Nuclear FOXI1 staining occurred in 96% of 83 ROs, in 3% of 90 chRCCs and none of the other tumor types.	ros	54-57	forkhead box I1	Homo sapiens	17-22
26567598-12	2015	Interestingly, we found that PKC proteins were downregulated by EGF in HCE cells that is partially mediated by ROS signaling, while PKC pathway was not involved in EGF-stimulated corneal cell proliferation and migration.	ros	111-114	epidermal growth factor	Homo sapiens	64-67
18164269-1	2008	The mitochondrial form of thioredoxin, thioredoxin 2 (Txn2), plays an important role in redox control and protection against ROS-induced mitochondrial damage.	ros	125-128	thioredoxin 2	Mus musculus	54-58
26238076-0	2015	ROS-induced nanotherapeutic approach for ovarian cancer treatment based on the combinatorial effect of photodynamic therapy and DJ-1 gene suppression.	ros	0-3	Parkinsonism associated deglycase	Homo sapiens	128-132
18164269-5	2008	Mitochondria isolated from Txn2(+/-) mice also showed increased ROS production compared to wild type mice.	ros	64-67	thioredoxin 2	Mus musculus	27-31
18164269-8	2008	Our results suggest that Txn2 plays an important role in protecting the mitochondria against oxidative stress and in sensitizing the cells to ROS-induced apoptosis.	ros	142-145	thioredoxin 2	Mus musculus	25-29
30976847-12	2019	In HL7702 cells exposed to ethanol, AST, ALT, lipid accumulation, and ROS generation decreased in cells that were treated with LRP6 inhibitors or siRNA but increased in cells treated with LRP6 activators or over-expressed LRP6.	ros	70-73	low density lipoprotein receptor-related protein 6	Mus musculus	127-131
26238076-1	2015	UNLABELLED: This study represents a novel approach for intraoperative ovarian cancer treatment based on the combinatorial effect of a targeted photodynamic therapy (PDT) associated with suppression of the DJ-1 protein, one of the key players in the ROS defense of cancer cells.	ros	249-252	Parkinsonism associated deglycase	Homo sapiens	205-209
17666570-0	2007	Reticulocyte-secreted exosomes bind natural IgM antibodies: involvement of a ROS-activatable endosomal phospholipase iPLA2.	ros	77-80	phospholipase A2 group VI	Rattus norvegicus	117-122
17639599-0	2007	High glucose stimulates GRO secretion from rat microglia via ROS, PKC, and NF-kappaB pathways.	ros	61-64	C-X-C motif chemokine ligand 1	Rattus norvegicus	24-27
26370081-9	2015	Importantly, human DJ-1, which is implicated in the familial form of Parkinson disease, complements the function of Hsp31 by suppressing methylglyoxal and oxidative stress, thus signifying the importance of these proteins in the maintenance of ROS homeostasis across phylogeny.	ros	244-247	Parkinsonism associated deglycase	Homo sapiens	19-23
17639599-9	2007	In addition, treatment with the ROS scavenger NAC (2 mM) significantly reduced the high glucose-induced phosphorylation of PKC and GRO secretion.	ros	32-35	C-X-C motif chemokine ligand 1	Rattus norvegicus	131-134
17707342-8	2007	Taken together, our observations suggest genipin signaling to apoptosis of PC3 cells is mediated via activation of ROS-dependent MLK3, which leads to downstream activation of JNK.	ros	115-118	proprotein convertase subtilisin/kexin type 1	Homo sapiens	75-78
31054074-4	2019	DJ-1 increases the expression of two mitochondrial uncoupling proteins (UCP 4 and UCP5), that decrease mitochondrial membrane potential and leads to the suppression of ROS production, optimizes of a number of mitochondrial functions, and is regarded as protection for the neuronal cell survival.	ros	168-171	solute carrier family 25 member 14	Homo sapiens	82-86
26385178-8	2015	These results demonstrate that a decrease in PTEN facilitates ROS/SHP2 signaling, causing lung cancer cells to become unresponsive to IFN-gamma.	ros	62-65	phosphatase and tensin homolog	Homo sapiens	45-49
31136958-6	2019	Consistently, inhibition of SGK1 via siRNA or pharmacological inhibitor GSK650394 induces ROS and cytotoxicity upon H2O2 stress.	ros	90-93	serum/glucocorticoid regulated kinase 1	Homo sapiens	28-32
31136958-9	2019	Importantly, we find that inhibition of SGK1 confers vulnerability to melatonin as a pro-oxidant, resulting in ROS over-accumulation and consequently enhanced cell cytotoxicity.	ros	111-114	serum/glucocorticoid regulated kinase 1	Homo sapiens	40-44
31138329-9	2019	CONCLUSIONS: Our study highlights the critical role of ROS-mediating CaMKII/Drp1 signaling in the regulation of mitochondrial fission and apoptosis induced by combination of CQ/IH.	ros	55-58	collapsin response mediator protein 1	Mus musculus	76-80
31191819-8	2019	ROS was implicated as being involved post-treatment with the involvement of TSPO and MPO.	ros	0-3	translocator protein	Homo sapiens	76-80
17616649-2	2007	To determine whether hypoxia-induced reactive oxygen and nitrogen species (ROS and RNS, respectively) may be involved in the downregulation of PKG-mediated relaxation, ovine fetal intrapulmonary veins were exposed to 4 h of normoxia or hypoxia, with or without scavengers of ROS [N-acetylcysteine (NAC)] or peroxynitrite (quercetin and Trolox) and preconstricted with endothelin-1.	ros	75-78	protein kinase cGMP-dependent 1	Homo sapiens	143-146
26086160-8	2015	Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway.	ros	22-25	synuclein alpha	Homo sapiens	15-18
17587483-1	2007	NOX5 is a ROS-generating NADPH oxidase which contains an N-terminal EF-hand region and can be activated by cytosolic Ca(2+) elevations.	ros	10-13	NADPH oxidase 5	Homo sapiens	0-4
31038133-8	2019	Collectively, our findings reveal that brosimone I induces cell cycle G1 phase arrest and apoptosis via the induction of ROS-mediated increased cytosolic Ca2+, ER stress, and the activation of the CaMKKbeta-AMPK signaling pathway.	ros	121-124	calcium/calmodulin dependent protein kinase kinase 1	Homo sapiens	197-206
30928096-7	2019	However, overexpression of fission protein 1 (Fis1) prevented H2 relaxin from protecting against AngII-induced low eNOS, SOD1 expression, excessive mitochondrial fission and increased ROS level in HUVECs.	ros	184-187	fission, mitochondrial 1	Homo sapiens	27-44
30928096-7	2019	However, overexpression of fission protein 1 (Fis1) prevented H2 relaxin from protecting against AngII-induced low eNOS, SOD1 expression, excessive mitochondrial fission and increased ROS level in HUVECs.	ros	184-187	fission, mitochondrial 1	Homo sapiens	46-50
26086160-8	2015	Interestingly, NAC, a ROS inhibitor, blocked iNOS expression, NO production, and activation of ERK and JNK MAPKs, which suggested that PFOS-mediated microglial NO production occurs via a ROS/ERK/JNK MAPK signaling pathway.	ros	187-190	synuclein alpha	Homo sapiens	15-18
26086368-8	2015	As it is indicated that reactive oxidative stress (ROS) is one of the activators for NLRP3 inflammasome, we further employed 2",7"-Dichlorodihydrofluorescein diacetate (DCFH-DA) staining and Rhodamine123 staining to detect intracellular ROS and mitochondrial membrane potential (MMP), respectively.	ros	51-54	NLR family, pyrin domain containing 3	Mus musculus	85-90
31073183-6	2019	Mechanistically, CD200R-deficient neutrophils display significantly reduced reactive oxygen species production (ROS), suggesting that CD200R-mediated ROS production in neutrophils is necessary for limiting F. tularensis colonisation and proliferation.	ros	112-115	CD200 receptor 1	Mus musculus	17-23
31073183-6	2019	Mechanistically, CD200R-deficient neutrophils display significantly reduced reactive oxygen species production (ROS), suggesting that CD200R-mediated ROS production in neutrophils is necessary for limiting F. tularensis colonisation and proliferation.	ros	112-115	CD200 receptor 1	Mus musculus	134-140
31073183-6	2019	Mechanistically, CD200R-deficient neutrophils display significantly reduced reactive oxygen species production (ROS), suggesting that CD200R-mediated ROS production in neutrophils is necessary for limiting F. tularensis colonisation and proliferation.	ros	150-153	CD200 receptor 1	Mus musculus	17-23
31073183-6	2019	Mechanistically, CD200R-deficient neutrophils display significantly reduced reactive oxygen species production (ROS), suggesting that CD200R-mediated ROS production in neutrophils is necessary for limiting F. tularensis colonisation and proliferation.	ros	150-153	CD200 receptor 1	Mus musculus	134-140
31056532-7	2019	Mechanically, overexpression of miR-124 was found to inhibit the expression of SIRT1 and thus promoted the generation of ROS and phosphorylation of JNK.	ros	121-124	sirtuin 1	Homo sapiens	79-84
31217063-5	2019	When treated with 400 mumol/L H2O2, NANOG hHF-MSCs showed higher cell survival rate, lower ROS production and apoptosis, higher expression of p-AKT, higher ratio of p-AKT/AKT.	ros	91-94	Nanog homeobox	Homo sapiens	36-41
30590774-8	2019	Overexpression of XIAP gene in HepG2 significantly blocks PCP/Cu(OP)2-induced cytotoxicity, caspase activity, apoptosis, ROS accumulation, and antioxidant genes expression.	ros	121-124	X-linked inhibitor of apoptosis	Homo sapiens	18-22
30909929-11	2019	In addition, treatment with the mitochondrial Ca2+-buffering protein parvalbumin significantly inhibited ROS/Nrf2/Notch pathway and MCUR1-induced EMT and HCC metastasis.	ros	105-108	parvalbumin	Homo sapiens	69-80
30475154-6	2019	Interestingly, inhibition of mitochondrial fission and mitochondrial ROS also resulted in decreased p62 expression, but Beclin1 and LC3B were unaffected.	ros	69-72	nucleoporin 62	Homo sapiens	100-103
30475154-7	2019	Taken together, these results indicate that ROS induction due to increased LPS-stimulated mitochondrial fission triggers p62 mediated autophagy in microglial cells.	ros	44-47	nucleoporin 62	Homo sapiens	121-124
30816299-1	2019	24 h exposure to 4  C primes Arabidopsis thaliana in the pre-bolting rosette stage for several days against full cold activation of the ROS responsive genes ZAT10 and BAP1 and causes stronger cold-induction of pleiotropically stress-regulated genes.	ros	136-139	BON association protein 1	Arabidopsis thaliana	167-171
30779746-0	2019	IL-11 prevents IFN-gamma-induced hepatocyte death through selective downregulation of IFN-gamma/STAT1 signaling and ROS scavenging.	ros	116-119	interleukin 11	Mus musculus	0-5
30779746-11	2019	Finally, we demonstrated that IL-11 pretreatment mitigated oxidative stress through increasing expression of ROS scavengers.	ros	109-112	interleukin 11	Mus musculus	30-35
30779746-12	2019	CONCLUSION: IL-11 protects hepatocytes from IFN-gamma-induced death via STAT1 signal suppression and ROS scavenging.	ros	101-104	interleukin 11	Mus musculus	12-17
30400061-2	2019	This tumor suppression system is based upon the kill switch being triggered in cells in which p53 has been inactivated; such kill switch consisting of a rapid, catastrophic increase in ROS caused by the induction of irreversible uncompetitive inhibition of glucose-6- phosphate dehydrogenase (G6PD), which requires high concentrations of both inhibitor (DHEA) and G6P substrate.	ros	185-188	glucose-6-phosphate dehydrogenase	Homo sapiens	257-291
30400061-2	2019	This tumor suppression system is based upon the kill switch being triggered in cells in which p53 has been inactivated; such kill switch consisting of a rapid, catastrophic increase in ROS caused by the induction of irreversible uncompetitive inhibition of glucose-6- phosphate dehydrogenase (G6PD), which requires high concentrations of both inhibitor (DHEA) and G6P substrate.	ros	185-188	glucose-6-phosphate dehydrogenase	Homo sapiens	293-297
30529121-3	2019	HSP significantly inhibited the proliferation of HeLa cells in vitro, and induced intracellular ROS accumulation.	ros	96-99	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	0-3
30480549-5	2019	Vasoconstriction blockade with the endothelin-1 inhibitor BQ-123, or ROS scavenging after SDRT using peroxiredoxin-6 overexpression or the SOD mimetic tempol, prevented chromatin SUMO3 depletion, HDR loss of function, and SDRT tumor ablation.	ros	69-72	small ubiquitin like modifier 3	Homo sapiens	179-184
31250603-8	2019	NOX4 siRNA blocked the accumulation of ROS in the high glucose cultured schwann cells, and reduced the damage of glucose on cell viability, by inhibiting NOX4 gene expression.	ros	39-42	NADPH oxidase 4	Rattus norvegicus	0-4
31250603-10	2019	CONCLUSION: Nox4 was involved in the hyperglycemic-induced apoptosis of schwann cells through ROS.	ros	94-97	NADPH oxidase 4	Rattus norvegicus	12-16
30500459-8	2019	NAC completely reversed BTPA-induced ROS-dependent mitochondrial-mediated intrinsic apoptosis.	ros	37-40	X-linked Kx blood group	Homo sapiens	0-3
30723477-8	2018	In vitro, SOCS2-/- hepatocytes expressed more p-NF-kB and produced more ROS than WT hepatocytes when exposed to APAP.	ros	72-75	suppressor of cytokine signaling 2	Mus musculus	10-15
30635606-14	2019	The ROS-scavenging system, including catalase, aldehyde dehydrogenase, and glutathione S-transferase, was also upregulated to alleviate ROS toxicity in the fast germinating genotype under low temperature stress.	ros	4-7	catalase-3-like	Brassica napus	37-45
30635606-14	2019	The ROS-scavenging system, including catalase, aldehyde dehydrogenase, and glutathione S-transferase, was also upregulated to alleviate ROS toxicity in the fast germinating genotype under low temperature stress.	ros	136-139	catalase-3-like	Brassica napus	37-45
30766661-6	2019	Moreover, TBBPA-induced activation of Akt/MAPK pathways and MMP-9 expression were attenuated by a specific NADPH oxidase inhibitor, and the ROS scavenger.	ros	140-143	matrix metallopeptidase 9	Homo sapiens	60-65
30766661-7	2019	These results suggest that TBBPA can induce cancer cell metastasis by releasing MMP-9 via ROS-dependent MAPK, and Akt pathways in MCF-7 cells.	ros	90-93	matrix metallopeptidase 9	Homo sapiens	80-85
30586869-0	2018	Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1.	ros	96-99	sequestosome 1	Homo sapiens	138-141
30586869-0	2018	Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1.	ros	96-99	sequestosome 1	Homo sapiens	142-148
30662585-0	2018	Parathyroid Hormone Causes Endothelial Dysfunction by Inducing Mitochondrial ROS and Specific Oxidative Signal Transduction Modifications.	ros	77-80	parathyroid hormone	Bos taurus	0-19
30662585-6	2018	In order to explore the underlying mechanisms, we assessed the production of total and mitochondrial ROS (tROS and mROS, respectively) in response to PTH (at 1 and 3 hours).	ros	101-104	parathyroid hormone	Bos taurus	150-153
30662585-7	2018	PTH increased ROS generation, to an extent high enough to determine oxidation of Bk receptor B2.	ros	14-17	parathyroid hormone	Bos taurus	0-3
30662585-12	2018	VEGFR2 oxidation occurred in response to PTH, suggesting that even the impairment of angiogenesis was due to the ROS surge.	ros	113-116	parathyroid hormone	Bos taurus	41-44
30662585-13	2018	These results indicate that PTH affects endothelial function through ROS production, driven by mitochondrial calcium overload.	ros	69-72	parathyroid hormone	Bos taurus	28-31
30359575-5	2018	We hypothesized that PARP-1 inhibition in diabetic mice may protect cardiomyocytes from inflammation and ROS production.	ros	105-108	poly (ADP-ribose) polymerase family, member 1	Mus musculus	21-27
30359575-13	2018	In-vitro experiments demonstrated that inhibition of PARP-1 in cardiomyocytes exposed to high levels of glucose and AT led to a significant reduction in ROS (P &lt; 0.01), which was abolished in the presence of the SIRT1 inhibitor together with increased protein expression of SIRT1 and PGC-1alpha.	ros	153-156	poly (ADP-ribose) polymerase family, member 1	Mus musculus	53-59
30531981-9	2018	Downregulation of NDUFA11 or SDHC reduced ATP production and increased mitochondrial ROS production.	ros	85-88	succinate dehydrogenase complex subunit C	Homo sapiens	29-33
30459314-3	2018	The Src homology/collagen (Shc) adaptor protein p66Shc is a key regulator of mitochondrial function, ROS production and aging.	ros	101-104	src homology 2 domain-containing transforming protein C1	Mus musculus	4-25
30459314-3	2018	The Src homology/collagen (Shc) adaptor protein p66Shc is a key regulator of mitochondrial function, ROS production and aging.	ros	101-104	src homology 2 domain-containing transforming protein C1	Mus musculus	27-30
30459314-3	2018	The Src homology/collagen (Shc) adaptor protein p66Shc is a key regulator of mitochondrial function, ROS production and aging.	ros	101-104	src homology 2 domain-containing transforming protein C1	Mus musculus	48-54
30459314-7	2018	Overexpression of p66Shc repressed glycolytic enzyme expression and increased both mitochondrial electron transport chain activity and ROS levels in HT22 cells.	ros	135-138	src homology 2 domain-containing transforming protein C1	Mus musculus	18-24
30459314-10	2018	Our findings indicate that expression and activation of p66Shc renders CNS cells more sensitive to Abeta toxicity by promoting mitochondrial OXPHOS and ROS production while repressing aerobic glycolysis.	ros	152-155	src homology 2 domain-containing transforming protein C1	Mus musculus	56-62
30451898-3	2018	We demonstrated that NUPR1 downregulation induces a mitochondrial failure with a loss of the mitochondrial membrane potential, a strong increase in ROS production and a concomitant relocalization of mitochondria to the vicinity of the endoplasmic reticulum (ER).	ros	148-151	nuclear protein transcription regulator 1	Mus musculus	21-26
30122554-5	2018	Decreased ROS production in KO-AOX versus KO mice led to impaired AMPK/PGC-1alpha signaling and PAX7/MYOD-dependent muscle regeneration, blunting compensatory responses.	ros	10-13	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	31-34
30122554-5	2018	Decreased ROS production in KO-AOX versus KO mice led to impaired AMPK/PGC-1alpha signaling and PAX7/MYOD-dependent muscle regeneration, blunting compensatory responses.	ros	10-13	paired box 7	Mus musculus	96-100
30236513-7	2018	Trx2 depletion enhances mitochondrial ROS generation without impact on cellular ROS level.	ros	38-41	thioredoxin 2	Rattus norvegicus	0-4
30236513-10	2018	To decipher the relationship between ROS generation, mitochondrial respiration flux, and AMPK signaling, mitochondrial metabolism and ROS was specifically inhibited, and the results show that AMPK inactivation and hypertrophic response in Trx2-silenced cells is reversed by respiration blockers but not ROS scavenger.	ros	37-40	thioredoxin 2	Rattus norvegicus	239-243
30106126-0	2018	miR-291b-3p mediated ROS-induced endothelial cell dysfunction by targeting HUR.	ros	21-24	microRNA 291b	Mus musculus	0-8
30292830-9	2018	At the molecular level, Sirt1 overexpression attenuated TNFalpha-mediated mitochondrial damage, as evidenced by increased mitochondrial energy metabolism, decreased mitochondrial ROS generation, stabilized mitochondrial potential and blockage of the mitochondrial apoptotic pathway.	ros	179-182	sirtuin 1	Homo sapiens	24-29
29446046-0	2018	Anti-neovascularization effects of DMBT in age-related macular degeneration by inhibition of VEGF secretion through ROS-dependent signaling pathway.	ros	116-119	vascular endothelial growth factor A	Mus musculus	93-97
30135216-10	2018	Impeding CLIC1-mediated chloride current prevents both intracellular ROS accumulation and pH changes.	ros	69-72	chloride intracellular channel 1	Homo sapiens	9-14
30001601-2	2018	And pNaKtide is known to inhibit Na/K-ATPase/Src/reactive oxygen species (ROS) amplification signaling.	ros	74-77	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	45-48
17603930-6	2007	The levels of reactive oxygen (ROS) and reactive nitrogen species (RNS), both intracellularly and in the medium, were higher for LNCaP cells than for PC3 cells during cell growth.	ros	31-34	chromobox 8	Homo sapiens	150-153
17508921-1	2007	Reactive oxygen (ROS) and nitrogen species (RNS) generation have been proposed to be an important mechanism of doxorubicin (Adriamycin; ADR)-induced cardiotoxicity and cardiomyocyte apoptosis, processes that may be mediated by p53 protein.	ros	17-20	transformation related protein 53, pseudogene	Mus musculus	227-230
17034344-6	2006	ROS induced by SIN-I exposure led to an increase in DJ-1 mRNA and protein levels in human glioma U-87 cells.	ros	0-3	Parkinsonism associated deglycase	Homo sapiens	52-56
17034344-9	2006	Upregulation of DJ-1 was noted in EAE, and similar results were observed in glioma cells exposed to ROS.	ros	100-103	Parkinsonism associated deglycase	Homo sapiens	16-20
16715208-6	2006	NAC, which inhibits the generation of ROS, suppresses the staurosporin-induced neurite outgrowth in HN33 cells.	ros	38-41	synuclein alpha	Homo sapiens	0-3
16481037-4	2006	Notably, adaphostin+/-bortezomib potently induced ROS and lethality in mutant cells, effects attenuated by the antioxidant NAC.	ros	50-53	synuclein alpha	Homo sapiens	123-126
16987006-10	2006	These data provide the first evidence, in MCs, of activation by AAof a p22( phox )-based NAD(P)H oxidase and subsequent generation of ROS.	ros	134-137	calcineurin like EF-hand protein 1	Homo sapiens	71-74
16819299-0	2006	CAGE, a novel cancer/testis antigen gene, promotes cell motility by activation ERK and p38 MAPK and downregulating ROS.	ros	115-118	DEAD-box helicase 53	Homo sapiens	0-4
16819299-6	2006	Overexpression of CAGE also resulted in a reduction of ROS and an increase of ROS scavenging, associated with induction of catalase activity.	ros	55-58	DEAD-box helicase 53	Homo sapiens	18-22
16819299-6	2006	Overexpression of CAGE also resulted in a reduction of ROS and an increase of ROS scavenging, associated with induction of catalase activity.	ros	78-81	DEAD-box helicase 53	Homo sapiens	18-22
16819299-7	2006	Inhibition of ERK and p38 MAPK increased ROS levels in cells transfected with CAGE, suggesting that ROS reduce the motility of both cell lines.	ros	41-44	DEAD-box helicase 53	Homo sapiens	78-82
16819299-7	2006	Inhibition of ERK and p38 MAPK increased ROS levels in cells transfected with CAGE, suggesting that ROS reduce the motility of both cell lines.	ros	100-103	DEAD-box helicase 53	Homo sapiens	78-82
16819299-9	2006	We conclude that CAGE enhances the motility of cancer cells by activating ERK and p38 MAPK, inducing catalase activity, and reducing ROS levels.	ros	133-136	DEAD-box helicase 53	Homo sapiens	17-21
16527821-4	2006	ROS production was the result of TNFalpha activation of Ser phosphorylation of NADPH oxidase subunit p47(phox) and its translocation to EC membranes.	ros	0-3	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	101-104
16614935-2	2006	Over-expression of CAGE enhanced growth rates, promoted cell motility and led to an ROS scavenging effect which was accompanied by an induced catalase cavity.	ros	84-87	DEAD-box helicase 53	Homo sapiens	19-23
16282349-11	2006	The antioxidant N-acetyl-L-cysteine diminished G-CSF-induced ROS production and cell proliferation by inhibiting Akt activation.	ros	61-64	colony stimulating factor 3	Homo sapiens	47-52
16282349-12	2006	These data suggest that the G-CSF-induced Lyn-PI3K-Akt pathway drives ROS production.	ros	70-73	colony stimulating factor 3	Homo sapiens	28-33
16210649-3	2005	In this paper we report on studies examining how the ROS hydrogen peroxide (H(2)O(2)) affects the production of MMP-1, COX-2, and PGE(2).	ros	53-56	matrix metallopeptidase 1	Homo sapiens	112-117
16164745-4	2005	We have hypothesized that equine airway sensitization might induce an oxidative stress and increase the ROS production, which in turn might enhance a production of IL-1beta and airway hyperresponsiveness.	ros	104-107	interleukin-1 beta	Equus caballus	164-172
16409112-3	2005	We stably expressed ER-alpha and ER-beta in ROS 17/2.8 cells and isolated several single cell clones.	ros	44-47	estrogen receptor 1	Rattus norvegicus	20-28
16409112-3	2005	We stably expressed ER-alpha and ER-beta in ROS 17/2.8 cells and isolated several single cell clones.	ros	44-47	estrogen receptor 2	Rattus norvegicus	33-40
15890751-10	2005	To determine whether strain-induced tyrosine kinase activity is necessary for strain-induced ROS-p42/44 MAP kinase signaling, genistein, a tyrosine kinase inhibitor, was used.	ros	93-96	cyclin dependent kinase 20	Homo sapiens	97-100
16463142-8	2005	As ZO-1 is an actin-binding protein, this suggested that the differences in Cx45t37 solubility might be due to a difference between the interaction of gap junctions and the actin cytoskeleton in the ROS/Cx45t37 and in the other transfected ROS cells.	ros	199-202	tight junction protein 1	Rattus norvegicus	3-7
16463142-8	2005	As ZO-1 is an actin-binding protein, this suggested that the differences in Cx45t37 solubility might be due to a difference between the interaction of gap junctions and the actin cytoskeleton in the ROS/Cx45t37 and in the other transfected ROS cells.	ros	240-243	tight junction protein 1	Rattus norvegicus	3-7
15876423-11	2005	These data suggest that induction of HO-1 protein may participate in the protective mechanism of QE on oxidative stress (H(2)O(2))-induced apoptosis, and reduction of intracellular ROS production and mitochondria dysfunction with blocking apoptotic events were involved.	ros	181-184	heme oxygenase 1	Homo sapiens	37-41
15855237-1	2005	ZO-1 is the major connexin-interacting protein in ROS 17/2.8 (ROS) osteoblastic cells.	ros	50-53	tight junction protein 1	Rattus norvegicus	0-4
15855237-1	2005	ZO-1 is the major connexin-interacting protein in ROS 17/2.8 (ROS) osteoblastic cells.	ros	62-65	tight junction protein 1	Rattus norvegicus	0-4
15855237-2	2005	We examined the role of ZO-1 in Cx43-mediated gap junction formation and function in ROS cells that expressed the connexin-interacting fragment of ZO-1 (ROS/ZO-1dn) cells.	ros	85-88	tight junction protein 1	Rattus norvegicus	147-151
15855237-2	2005	We examined the role of ZO-1 in Cx43-mediated gap junction formation and function in ROS cells that expressed the connexin-interacting fragment of ZO-1 (ROS/ZO-1dn) cells.	ros	153-156	tight junction protein 1	Rattus norvegicus	147-151
15855237-3	2005	Expression of this ZO-1(7-444) fusion protein in ROS cells disrupted the Cx43/ZO-1 interaction and decreased dye transfer by 85%, although Cx43 was retained on the plasma membrane as assessed by surface biotinylation.	ros	49-52	tight junction protein 1	Rattus norvegicus	19-23
15855237-3	2005	Expression of this ZO-1(7-444) fusion protein in ROS cells disrupted the Cx43/ZO-1 interaction and decreased dye transfer by 85%, although Cx43 was retained on the plasma membrane as assessed by surface biotinylation.	ros	49-52	tight junction protein 1	Rattus norvegicus	78-82
15459075-4	2004	Recent studies have shown that NAD(P)H oxidase-derived reactive oxidant species (ROS) are important mediators of Ang II signaling.	ros	81-84	NADPH oxidase 1	Oryctolagus cuniculus	31-46
15459075-4	2004	Recent studies have shown that NAD(P)H oxidase-derived reactive oxidant species (ROS) are important mediators of Ang II signaling.	ros	81-84	angiogenin	Oryctolagus cuniculus	113-116
15507765-1	2004	The NOX family of ROS-generating NADPH oxidases consists of 7 members: NOX1 to NOX5, DUOX1 and 2.	ros	18-21	NADPH oxidase 5	Homo sapiens	79-83
15197348-5	2004	The reduction in cell growth and enhancement in cell killing by the combination of GST-MDA-7 and radiation were blocked by an ROS scavenger, N-acetyl cysteine (NAC), a JNK1/2/3 inhibitor SP600125, a pan-caspase inhibitor (zVAD) and by an inhibitor of caspase 9 (LEHD), but not by an inhibitor of caspase 8 (IETD).	ros	126-129	interleukin 24	Homo sapiens	87-92
15197348-5	2004	The reduction in cell growth and enhancement in cell killing by the combination of GST-MDA-7 and radiation were blocked by an ROS scavenger, N-acetyl cysteine (NAC), a JNK1/2/3 inhibitor SP600125, a pan-caspase inhibitor (zVAD) and by an inhibitor of caspase 9 (LEHD), but not by an inhibitor of caspase 8 (IETD).	ros	126-129	caspase 9	Homo sapiens	251-260
15117824-1	2004	Apoptosis signal-regulating kinase 1 (ASK1) mediates cytokines and oxidative stress (ROS)-induced apoptosis in a mitochondria-dependent pathway.	ros	85-88	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	0-36
15117824-1	2004	Apoptosis signal-regulating kinase 1 (ASK1) mediates cytokines and oxidative stress (ROS)-induced apoptosis in a mitochondria-dependent pathway.	ros	85-88	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	38-42
14751567-3	2004	In sub-confluent ROS.SMER#14 cells, which express an exogenous plus small amounts of the endogenous ERalpha gene, the receptor appeared as two main bands of approximately 66 and approximately 46 kDa.	ros	17-20	estrogen receptor 1	Rattus norvegicus	100-107
14751567-6	2004	In contrast, negligible membrane translocation of PKCalpha and/or activated c-Src was observed in parental ROS 17/2.8 cells, which express low levels of full-length ERalpha.	ros	107-110	estrogen receptor 1	Rattus norvegicus	165-172
14679790-3	2003	TRX shows not only scavenging activity for ROS, but also regulating activity for various intracellular molecules including transcription factors.	ros	43-46	thioredoxin	Homo sapiens	0-3
12603823-7	2003	Exposure of neurons to ROS for 6 h resulted in basal and fibroblast growth factor-2-stimulated phosphorylation/activation of CREB.	ros	23-26	cAMP responsive element binding protein 1	Rattus norvegicus	125-129
12603823-8	2003	Chronic 24 h treatment with ROS led to a significant (p &lt; 0.01) decrease in CREB protein and CREB mRNA levels.	ros	28-31	cAMP responsive element binding protein 1	Rattus norvegicus	79-83
12603823-8	2003	Chronic 24 h treatment with ROS led to a significant (p &lt; 0.01) decrease in CREB protein and CREB mRNA levels.	ros	28-31	cAMP responsive element binding protein 1	Rattus norvegicus	96-100
12603823-9	2003	Adenoviral overexpression of wild type CREB in H19-7 cells resulted in significant (p &lt; 0.01) protection against ROS-induced apoptosis through up-regulation of Bcl-2 expression whereas dominant negative CREB exaggerated the injury.	ros	116-119	cAMP responsive element binding protein 1	Rattus norvegicus	39-43
12607822-13	2002	Synaptosomes from apoE knock-out mice are more vulnerable to Abeta-induced oxidative stress (protein oxidation, lipid peroxidation, and ROS generation) than are those from wild-type mice.	ros	136-139	amyloid beta (A4) precursor protein	Mus musculus	61-66
12207667-6	2002	Our results suggest that a drought-associated oxidative stress induces accumulation of GST8, whose function could be to counteract the effect of higher ROS production in stressed plants	ros	152-155	glutathione S-transferase TAU 19	Arabidopsis thaliana	87-91
30323337-5	2018	Mechanistically, TA depletion combined with HER2 inhibition significantly reduces cellular NADPH levels, resulting in excessive ROS production and deficient lipid and nucleotide synthesis.	ros	128-131	transaldolase 1	Homo sapiens	17-19
30056145-9	2018	The mechanism may be related to reduce ROS generating sources and associated oxidative damage, decrease the influence of pro-inflammatory cytokines, and suppress the activity of hepatic stellate cells and downregulation TIMP1, PCNA, Col-III, alpha-SMA and up-regulation MMP-9.	ros	39-42	proliferating cell nuclear antigen	Mus musculus	227-231
29277549-9	2018	Taken together, our data suggest that mTOR plays a key role in mediating ROS-induced MC apoptosis in diabetic nephropathy, and these effects have been associated with the promotion of ROS production by upregulating the antioxidant enzyme and downregulating the NADPH oxidase activity.	ros	73-76	mechanistic target of rapamycin kinase	Rattus norvegicus	38-42
29277549-9	2018	Taken together, our data suggest that mTOR plays a key role in mediating ROS-induced MC apoptosis in diabetic nephropathy, and these effects have been associated with the promotion of ROS production by upregulating the antioxidant enzyme and downregulating the NADPH oxidase activity.	ros	184-187	mechanistic target of rapamycin kinase	Rattus norvegicus	38-42
30245856-9	2018	Declined p62, LC3 expression were accompanied with increased Akt, Keap1, ROS, and vinorelbine-induced apoptosis after modification of A549 cells with PTEN knockdown, Atg5 knockdown, and Keap1 overexpression.	ros	73-76	nucleoporin 62	Homo sapiens	9-12
26166436-11	2015	C/EBPbeta knockdown and beta-catenin activation could significantly promote the invasion of HTR8/SVneo cells, enhance the outgrowth and migration in villous explants and inhibit the excessive generation of intracellular ROS.	ros	220-223	catenin beta 1	Homo sapiens	24-36
30187255-11	2018	Upregulation of UCP2 mRNA resulted in a decrease in mitochondrial ROS generation 24 h after the onset of CLP, whereas ROS over-generation associated with slip at cytochrome c oxidase observed at 36 h was concomitant with a decrease in UCP2 mRNA expression.	ros	66-69	uncoupling protein 2	Rattus norvegicus	16-20
11799110-0	2002	The role of phosphatidylinositol 3-kinase, rho family GTPases, and STAT3 in Ros-induced cell transformation.	ros	76-79	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	12-41
26197455-8	2015	Furthermore, Tregs cells from the CCR4-/- septic mice showed reduced suppressive effects on neutrophil migration (both in vivo and in vitro), lymphocyte proliferation and ROS production from activated neutrophils, in contrast with what was observed for Tregs from the WT septic mice.	ros	171-174	chemokine (C-C motif) receptor 4	Mus musculus	34-38
11799110-1	2002	Using loss-of-function mutants of Ros and inducible epidermal growth factor receptor-Ros chimeras we investigated the role of various signaling pathways in Ros-induced cell transformation.	ros	85-88	epidermal growth factor receptor	Mus musculus	52-84
11799110-1	2002	Using loss-of-function mutants of Ros and inducible epidermal growth factor receptor-Ros chimeras we investigated the role of various signaling pathways in Ros-induced cell transformation.	ros	85-88	epidermal growth factor receptor	Mus musculus	52-84
30103844-8	2018	Furthermore, our studies show that over-expression of ASCT2 can attenuate cisplatin-induced ROS production, gammaH2AX foci formation and apoptosis in human hepatoma cells.	ros	92-95	solute carrier family 1 member 5	Homo sapiens	54-59
26161534-7	2015	Furthermore, PINK1 and Parkin prevented PA-induced mitochondrial dysfunction, ROS production and apoptosis.	ros	78-81	PTEN induced putative kinase 1	Mus musculus	13-18
29729283-5	2018	Next, we showed that priming of chicken macrophages with IFNalpha increased bacteria uptake, boosted bacterial-induced ROS/NO production and led to an increased transcriptional expression or production of NOS2/NO, IL1B/IL-1beta and notably IFNB/IFNbeta.	ros	119-122	interferon	Gallus gallus	57-65
12014661-7	2002	The direction of generation of apoptosis inducing ROS and RNS to the site of superoxide anion production has relevance for the selectivity of ROS and RNS-based natural antitumor systems, as extracellular superoxide anion generation represents a hallmark of the transformed state.	ros	50-53	FAM20C golgi associated secretory pathway kinase	Homo sapiens	150-153
12014661-7	2002	The direction of generation of apoptosis inducing ROS and RNS to the site of superoxide anion production has relevance for the selectivity of ROS and RNS-based natural antitumor systems, as extracellular superoxide anion generation represents a hallmark of the transformed state.	ros	142-145	FAM20C golgi associated secretory pathway kinase	Homo sapiens	58-61
25977220-0	2015	LKB1 Inactivation Promotes ROS-Induced Plasticity in NSCLC.	ros	27-30	serine/threonine kinase 11	Homo sapiens	0-4
11748579-16	2001	CONCLUSIONS: This study demonstrated that ROs can be distinguished reliably from RCCs on the basis of cytologic morphology combined with ancillary studies, including immunostaining with cytokeratin and vimentin antibodies and HCI stain.	ros	42-45	vimentin	Homo sapiens	202-210
29294217-6	2018	Notably, silencing of RBX1 expression substantially declines cell death and generation of mitochondrial ROS in response to prolonged mitochondrial damage.	ros	104-107	ring-box 1	Homo sapiens	22-26
29940424-5	2018	Results showed that signaling levels of cellular ROS generated by TNFalpha, induced enrichment of OGG1 at specific sites of chromatinized DNA, primarily in the regulatory regions of genes.	ros	49-52	8-oxoguanine DNA-glycosylase 1	Mus musculus	98-102
29940424-8	2018	Taken together these data show TNFalpha-ROS-driven enrichment of OGG1 at gene regulatory regions in the chromatinized DNA, which is a prerequisite to modulation of gene expression for prompt cellular responses to oxidant stress.	ros	40-43	8-oxoguanine DNA-glycosylase 1	Mus musculus	65-69
25684443-11	2015	The current study suggests that PAR-2 activation leads to up-regulation of the DUOX-2/ROS pathway in AECs, which is involved in regulation of airway reactivity and inflammation via oxidative stress and apoptosis.	ros	86-89	coagulation factor II (thrombin) receptor-like 1	Mus musculus	32-37
25945832-4	2015	Drug-induced Trx1 (PX-12) and TrxR1 (Auranofin) inhibition disrupted redox homeostasis resulting in ROS-induced apoptosis in MM cells and a reduction in clonogenic activity.	ros	100-103	thioredoxin	Homo sapiens	13-17
29717768-0	2018	Breviscapine ameliorates CCl4-induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation.	ros	114-117	chemokine (C-C motif) ligand 4	Mus musculus	25-29
29981304-7	2018	CONCLUSIONS: Our results suggest that Drp1 contributes to the pathogenesis of hypertensive cardiac hypertrophy via ROS production and the Drp1 suppression may be effective to prevent the hypertensive cardiac hypertrophy.	ros	115-118	dynamin 1-like	Rattus norvegicus	38-42
25817730-7	2015	Knockdown of TNFR1 or RIPK1 impairs the activation of p38, blocks the cleavage of PARP, and provides partially, yet significantly protection from cell death, including reducing the ROS generation in the colon cancer cells.	ros	181-184	TNF receptor superfamily member 1A	Homo sapiens	13-18
29665408-5	2018	We used rotenone-induced neuron injury models to evaluate changes in cultured CATH.a cell lines levels of SOD, GSH and ROS.	ros	119-122	cathepsin H	Mus musculus	78-82
30021162-4	2018	Drug delivery subverted the phenotype of tumor-infiltrating CD11b+ Ly6Chi Ly6G- myeloid cells, favoring NOS2/ROS secretion and pro-inflammatory genes characteristic of M1 polarization.	ros	109-112	integrin subunit alpha M	Homo sapiens	60-65
25817730-7	2015	Knockdown of TNFR1 or RIPK1 impairs the activation of p38, blocks the cleavage of PARP, and provides partially, yet significantly protection from cell death, including reducing the ROS generation in the colon cancer cells.	ros	181-184	receptor interacting serine/threonine kinase 1	Homo sapiens	22-27
29565730-10	2018	Both the ROS scavenger NAC and the specific p38 inhibitor SB203580 inactivated the function of p38 induced by A-macB, thus preventing cells from apoptosis.	ros	9-12	NLR family, pyrin domain containing 1A	Mus musculus	23-26
25639646-7	2015	In the presence of TNF-alpha, NLRX1 and active subunits of Caspase-8 are preferentially localized to mitochondria and regulate the mitochondrial ROS generation.	ros	145-148	caspase 8	Mus musculus	59-68
29858119-8	2018	In addition, the ROS production and the activation of P13K/AKT/mTOR signaling induced by PDGF-BB were also suppressed by miR-27b overexpression or Nox2 silencing.	ros	17-20	cytochrome b-245 beta chain	Homo sapiens	147-151
27509686-5	2015	This leads to an increase of ROS production which in turn could regulate signaling pathways sensitive to oxidative stress such as gene-encoding matrix metalloproteases MMP1, MMP13 and Adamalysin ADAMTS4.	ros	29-32	matrix metallopeptidase 1	Homo sapiens	168-172
25705884-2	2015	Here we demonstrate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reductase (TRXR) system and activates the inflammasome through endosome-generated ROS.	ros	191-194	thioredoxin	Homo sapiens	87-98
30050588-8	2018	In addition, FP can decrease ROS production induced by MI and Ang II in vivo and vitro.	ros	29-32	angiogenin	Rattus norvegicus	62-65
30046376-8	2018	The mitochondrial dynamic imbalance and damage in DCM development were mainly associated with OPA1 downregulation, which may be caused by elevated TNF-alpha level and ROS stress after TLR4 activation.	ros	167-170	OPA1, mitochondrial dynamin like GTPase	Mus musculus	94-98
25705884-2	2015	Here we demonstrate that ATP signaling through macrophage P2X7 receptors uncouples the thioredoxin (TRX)/TRX reductase (TRXR) system and activates the inflammasome through endosome-generated ROS.	ros	191-194	thioredoxin	Homo sapiens	100-103
25766900-7	2015	Furthermore, treatment with the autophagy inhibitor 3-MA or ATM inhibitor KU55933 resulted in enhanced ROS accumulation and attenuation of the effect of prolonged FDT-mediated protection on irradiated HEI-OC1 cells.	ros	103-106	ATM serine/threonine kinase	Homo sapiens	60-63
30013443-10	2018	Consistently, our data revealed as well that mitigation of intracellular ROS levels with antioxidant NAC markedly attenuated H2O2-induced AMPK activation and ER stress.	ros	73-76	X-linked Kx blood group	Homo sapiens	101-104
29571735-6	2018	Moreover, gp91 ds-tat delivery and DHE staining results showed that NOX2-derived ROS was responsible for neomycin ototoxicity.	ros	81-84	cytochrome b-245 beta chain	Homo sapiens	68-72
25140833-5	2015	In this report, we show that the E3 ubiquitin ligase, c-CBL, is overexpressed in CTCL and that its knockdown overcomes defective TCR signaling, resulting in phosphorylation of PLC-g1, calcium influx, ROS generation, upregulation of FASL, and extrinsic pathway apoptosis in CTCL cells expressing adequate FAS.	ros	200-203	Cbl proto-oncogene	Homo sapiens	54-59
29571735-7	2018	Taken together, our study shows that regional up-expression of NOX2 and subsequent increase of ROS in OHCs of the basal turn is an important factor contributing to the vulnerability of OHCs there, which should shed light on the prevention of hearing loss induced by aminoglycoside antibiotics.	ros	95-98	cytochrome b-245 beta chain	Homo sapiens	63-67
25553592-8	2015	The pretreatment of HepG2 cells with the ROS inhibitor NAC reduced autophagosome formation and reversed the CIT cytotoxicity, indicating that CIT-induced autophagic cell death was ROS-dependent.	ros	41-44	synuclein alpha	Homo sapiens	55-58
29678463-5	2018	Meanwhile, Da-1 caused the accumulation of intracellular ROS, regulated JNK and AKT signaling, and down-regulated the expression levels of P-gp and MRP1 proteins.	ros	57-60	immunoglobulin heavy diversity 4-11 (non-functional)	Homo sapiens	11-15
25772107-5	2015	But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference.	ros	50-53	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	125-130
29653689-7	2018	LPS promoted P-selectin expression and intracellular ROS production, and both TAK242 and N-acetyl-L-cysteine (NAC) could depressed the LPS-induced increase of P-selectin and intracellular ROS.	ros	188-191	X-linked Kx blood group	Homo sapiens	110-113
29348462-9	2018	Ectopic expression of GSTP1 or pre-treatment with antioxidant N-acetyl-L-cysteine (NAC) abrogates the ROS elevation and decreases DNA damage, apoptosis, and autophagic cell death prompted by PL/APR-246.	ros	102-105	X-linked Kx blood group	Homo sapiens	83-86
25772107-7	2015	These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.	ros	121-124	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
25449783-4	2015	When cells were treated with various inhibitors of ROS generation to prevent hypoxia-induced ROS function, IL-32beta production was suppressed by both NADPH oxidase and mitochondrial ROS inhibitors.	ros	51-54	interleukin 32	Homo sapiens	107-116
29950247-2	2018	The recent studies showed that all of S100A9/TLR4, S100A9/CD33 and Nox/ROS signaling pathways can activate oxygen-sensitivity NLRP3 inflammasome and then induce the pyroptosis of hematopoeitic stem cells (HSC) / hematopeitic pregenitor cells (HPC), resulting in ineffective hematopoiesis in patients with MDS.	ros	71-74	S100 calcium binding protein A9	Homo sapiens	38-44
29274570-8	2018	Inhibitor studies revealed that OGDH and Complex III served as high capacity ROS release sites in liver mitochondria.	ros	77-80	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	Mus musculus	32-36
25449783-4	2015	When cells were treated with various inhibitors of ROS generation to prevent hypoxia-induced ROS function, IL-32beta production was suppressed by both NADPH oxidase and mitochondrial ROS inhibitors.	ros	93-96	interleukin 32	Homo sapiens	107-116
25449783-4	2015	When cells were treated with various inhibitors of ROS generation to prevent hypoxia-induced ROS function, IL-32beta production was suppressed by both NADPH oxidase and mitochondrial ROS inhibitors.	ros	93-96	interleukin 32	Homo sapiens	107-116
29304479-8	2018	In addition, the levels of intracellular ROS were significantly increased or decreased in H9C2 cells treated with DOX after miR-140-5p mimic or miR-140-5p inhibitor transfection, respectively, as well as the changed expression levels of Nrf2 and Sirt2.	ros	41-44	sirtuin 2	Rattus norvegicus	246-251
25449783-9	2015	These findings revealed that a hypoxia-ROS-IL-32beta-Src-glycolysis pathway is associated with the regulation of cancer cell metabolism.	ros	39-42	interleukin 32	Homo sapiens	43-52
29362867-6	2018	These findings suggest that SCF-stimulated melanogenesis can be abrogated by interrupting MSK1 phosphorylation, providing evidence for involvement of the p38/MSK1/CREB/MITF axis, providing new evidence for the ROS depletion independent interruption by antioxidants of SCF-triggered signaling.	ros	210-213	KIT ligand	Homo sapiens	28-31
25627963-4	2015	Our results showed that ASK1 knockdown alleviated OTA-induced ROS generation and Deltapsim loss and thus desensitized the cells to OTA-induced apoptosis.	ros	62-65	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	24-28
29377505-13	2018	Increased ROS production from NOX2 is a possible molecular mechanism responsible for developmental origins of cardiovascular disease in offspring of diabetic mothers.	ros	10-13	cytochrome b-245 beta chain	Homo sapiens	30-34
29475156-4	2018	6p also significantly induces both EC9706 and EC109 cell cycle arrest at G0/G1 phase and cell apoptosis, as well as intracellular ROS accumulation, which could be markedly reversed caspase or ROS inhibitor: NAC.	ros	192-195	X-linked Kx blood group	Homo sapiens	207-210
25967962-7	2015	RESULTS: Leptin signalling increased cell proliferation but reduced ROS production, as well as, oxidative damage.	ros	68-71	leptin	Homo sapiens	9-15
29523849-6	2018	Furthermore, the antioxidant compound Sulforaphane downregulates p63-iRHOM2 expression, leading to reduced proliferation, inflammation, survival and ROS production.	ros	149-152	rhomboid 5 homolog 2	Homo sapiens	69-75
26553010-1	2015	Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated.	ros	126-129	proline dehydrogenase 1	Homo sapiens	22-37
29427714-6	2018	The results of immunostaining showed that LV-PRDX3 transfection markedly reduced TNI-induced intracellular ROS production, protein radical formation and lipid peroxidation.	ros	107-110	peroxiredoxin 3	Homo sapiens	45-50
29229420-7	2018	In addition, caspase inhibitor Z-VAD-FMK and reactive oxidative species (ROS) scavenger N-acetyl-l-cysteine (NAC) apparently blocked QCT-induced cell death and VDAC2 oligomerization.	ros	73-76	X-linked Kx blood group	Homo sapiens	109-112
29330265-1	2018	PIN4 is a FGFR3-TACC3 substrate required for ROS-mediated induction of PGCIalpha and tumor growth.	ros	45-48	fibroblast growth factor receptor 3	Homo sapiens	10-15
26553010-1	2015	Proline dehydrogenase/proline oxidase (PRODH/POX) is an enzyme catalyzing the first step of proline degradation, during which ROS and/or ATP is generated.	ros	126-129	proline dehydrogenase 1	Homo sapiens	39-48
29552311-7	2018	Overexpression of miR-29b in oxaliplatin-treated OR-SW480 decreased the expression of SIRT1 to enhance the ROS production and JNK phosphorylation, and thus promoting apoptosis via activation of caspase 9, 7 and 3.	ros	107-110	sirtuin 1	Homo sapiens	86-91
26553010-5	2015	Due to ROS generation, POX may induce caspase-9 activity, which mediates mitochondrial apoptosis (intrinsic apoptosis pathway).	ros	7-10	proline dehydrogenase 1	Homo sapiens	23-26
26553010-5	2015	Due to ROS generation, POX may induce caspase-9 activity, which mediates mitochondrial apoptosis (intrinsic apoptosis pathway).	ros	7-10	caspase 9	Homo sapiens	38-47
25561933-3	2015	Our results were similar to our previous study which discovered CSE toxicity mechanisms on isolated mitochondria obtained from lung, heart and brain with minor changes.CSE induced a significant rise in ROS formation, lipid peroxidation and mitochondrial membrane potential collapse and mitochondrial swelling on isolated mitochondria obtained from both liver and skin.	ros	202-205	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	168-171
29076434-9	2018	Furthermore, exposure to ROS scavengers (N-acetyl-l-cysteine (NAC), and JNK-specific inhibitor SP600125) significantly reversed the effects of CJK-7 by down-regulating apoptosis and autophagy signatures in HCT-116 cancer cells.	ros	25-28	X-linked Kx blood group	Homo sapiens	62-65
25315681-7	2015	PARK2 mutant neuroprogenitors also showed a substantial increase in mitochondrial fragmentation, initial ROS generation, and loss of mitochondrial membrane potential following Cu exposure.	ros	105-108	parkin RBR E3 ubiquitin protein ligase	Homo sapiens	0-5
29912629-0	2018	ROS is the major player in regulating altered autophagy and lifespan in sin-3 mutants of C. elegans.	ros	0-3	Paired amphipathic helix protein sin-3	Caenorhabditis elegans	72-77
29912629-5	2018	We provide evidence that the enhanced autophagy and decreased lifespan observed in sin-3 deletion mutants is dependent on ROS and intracellular oxidative stress.	ros	122-125	Paired amphipathic helix protein sin-3	Caenorhabditis elegans	83-88
30231241-11	2018	CONCLUSION: Taken together, we conclude that ROS produced by 5-ALA-SDT could initiate PINK1/Parkin-mediated mitophagy which may exert a protective effect against 5-ALA-SDT-induced cell death in MCF-7 cells.	ros	45-48	PTEN induced kinase 1	Homo sapiens	86-91
26078825-9	2015	Our data, for the first time, show that H2S prevents AGEs-induced ENaC activation by targeting the ROS/PI3K/PTEN pathway.	ros	99-102	phosphatase and tensin homolog	Homo sapiens	108-112
29045036-7	2018	Then, we found inhibition of overproduction of ROS with antioxidant NAC attenuated obviously OGD-induced parthanatos in SH-SY5Y cells, suggesting ROS regulated OGD-induced parthanatos.	ros	47-50	X-linked Kx blood group	Homo sapiens	68-71
29045036-7	2018	Then, we found inhibition of overproduction of ROS with antioxidant NAC attenuated obviously OGD-induced parthanatos in SH-SY5Y cells, suggesting ROS regulated OGD-induced parthanatos.	ros	146-149	X-linked Kx blood group	Homo sapiens	68-71
25156511-3	2015	The 17 SNPs analyzed are involved in the ROS pathway (GSTP1, SOD2, NQO1, NOS3, XDH), DNA repair (XRCC1, XRCC3, XRCC6, ERCC2, LIG4, ATM) or TGFB signaling (SKIL, EP300, APC, AXIN1, TGFB1).	ros	41-44	glutathione S-transferase pi 1	Homo sapiens	54-59
29851009-4	2018	It was demonstrated that in isolated brown adipose tissue mitochondria (1) mGPDH enzyme activity is maximal at free calcium ion concentrations in the 350 nM-1 muM range, (2) that ROS production also peaks in the 10-100 nM range in the presence of a UCP1 inhibitory ligand (GDP) but wanes with further increasing calcium concentration, and (3) that oxygen consumption rates peak in the 10-100 nM range with rates being maintained at higher calcium concentrations.	ros	179-182	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	75-80
28823537-13	2018	Moreover, ROS generation occurred upon treatment of SH-SY5Y cells with HPO-DAEE, and the antioxidants N-acetylcysteine and glutathione suppressed HPO-DAEE-induced activation of the Nrf2-ARE and eIF2alpha-ATF4 pathways.	ros	10-13	eukaryotic translation initiation factor 2A	Homo sapiens	194-203
28823537-13	2018	Moreover, ROS generation occurred upon treatment of SH-SY5Y cells with HPO-DAEE, and the antioxidants N-acetylcysteine and glutathione suppressed HPO-DAEE-induced activation of the Nrf2-ARE and eIF2alpha-ATF4 pathways.	ros	10-13	activating transcription factor 4	Homo sapiens	204-208
28988741-7	2017	RESULTS: Over-expression of Smad7 dampened the ability of Ang II to promote ROS synthesis and inhibited the ability of Ang II to decrease functional expression of IkappaBalpha.	ros	76-79	angiogenin	Rattus norvegicus	58-61
29160717-7	2017	The suppressed MsrA facilitated the EGFRT790M degradation through 790M oxidation by ROS, thus resensitizing the EGFRT790M-positive cells to gefitinib.	ros	84-87	methionine sulfoxide reductase A	Homo sapiens	15-19
29151490-10	2017	PPARgamma"s beneficial effects seem to result from various factors, including anti-apoptosis, preservation RV index, reversal of inflammation, improvement of glucolipid metabolism, reduction of ROS.	ros	194-197	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	0-9
29416728-8	2018	DPI (inhibitor of ROS from NOX) or NAC (inhibitor of ROS) supplement reduced PM2.5-induced inflammatory activation and BMSCs differentiation.	ros	53-56	X-linked Kx blood group	Homo sapiens	35-38
28277969-9	2017	It is concluded that NO inhibitors and ROS inhibitor inhibited magnetic field induced promotion of seedling parameters and alpha- amylase activity of maize seeds.	ros	39-42	alpha-amylase	Zea mays	123-137
28748915-4	2017	Treatment of H9c2 cells with apelin-13 (0.001-2 mumol/L) dose-dependently increased the production of ROS and the expression levels of NADPH oxidase 4 (NOX4).	ros	102-105	apelin	Rattus norvegicus	29-35
29114996-4	2017	Here, we showed that intermittent exposure to hyperoxia, which induces oxidative stress resistance and lowers the production of ROS derived from mitochondrial respiration in C. elegans, slightly improved the lifespan extension of cep-1 mutant.	ros	128-131	Transcription factor cep-1	Caenorhabditis elegans	230-235
29182677-8	2017	The pub12 pub13 mutant exhibited enhanced chitin-induced immune responses such as ROS production, MAPK activation, and callose deposition.	ros	82-85	plant U-box 13	Arabidopsis thaliana	10-15
29089467-9	2017	RESULTS: Expression of STIM1/Orai1/TRPC1 significantly increased in transcript and translation level after MIRI in vivo and H/R in vitro In H9C2 cardiomyocytes subjected to H/R, intracellular Ca2+ accumulation significantly increased compared with control group, along with enhanced mPTP opening and elevated ROS generation.	ros	309-312	ORAI calcium release-activated calcium modulator 1	Rattus norvegicus	29-34
29089467-9	2017	RESULTS: Expression of STIM1/Orai1/TRPC1 significantly increased in transcript and translation level after MIRI in vivo and H/R in vitro In H9C2 cardiomyocytes subjected to H/R, intracellular Ca2+ accumulation significantly increased compared with control group, along with enhanced mPTP opening and elevated ROS generation.	ros	309-312	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	35-40
29176033-7	2017	Furthermore, we show STAT1/3 activation is necessary for cytokine and ROS production during TNFalpha-induced senescence.	ros	70-73	signal transducer and activator of transcription 1	Homo sapiens	21-28
29312589-6	2017	G6PD up-regulated ROS generation by facilitating NADPH-dependent NOX4 activation, which led to increased expression of p-STAT3 and CyclinD1.	ros	18-21	glucose-6-phosphate dehydrogenase	Homo sapiens	0-4
28358581-7	2017	Catalase overexpression reversed MnTnHex-2-PyP-enhanced ROS production and apoptosis.	ros	56-59	pyrophosphatase (inorganic) 1	Mus musculus	43-46
28602833-6	2017	Furthermore, our results firstly showed that IL-1RA-PEP also regulated the oxidases expression, decreased the levels of NO, MDA and ROS.	ros	132-135	interleukin 1 receptor antagonist	Rattus norvegicus	45-51
28602833-7	2017	In addition, the inhibitory effects of IL-1RA-PEP on oxidative stress and inflammation were confirmed in rat cortical neurons induced by OGD/R, it reduced ROS, IL-6 and TNF-alpha.	ros	155-158	interleukin 1 receptor antagonist	Rattus norvegicus	39-45
28790012-5	2017	The results indicated Mdivi-1(a selective Drp1 inhibitor) reversed the morphologic changes of mitochondria and Drp1 translocation, reduced ROS levels, ameliorated the BBB disruption and brain edema remarkably, decreased the expression of MMP-9 and prevented degradation of tight junction proteins-occludin, claudin-5 and ZO-1.	ros	139-142	dynamin 1-like	Rattus norvegicus	42-46
28366933-0	2017	A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.	ros	130-133	dynamin 2	Homo sapiens	22-26
28366933-6	2017	Importantly, a new AHI-1-BCR-ABL-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS-mediated autophagy.	ros	175-178	dynamin 2	Homo sapiens	33-37
29107291-9	2017	CONCLUSIONS: In high-fat fed mice, loss of S6K1 mimics endurance exercise training by reducing mitochondrial ROS production and upregulating oxidative utilization of ketone bodies.	ros	109-112	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	43-47
28709747-6	2017	This review summarizes the first indications that the innate immune system indeed has tools to disrupt viral ROs and other non- or aberrant-self membrane structures, and may do this by marking these membranes with proteins such as microtubule-associated protein 1A/1B-light chain 3 (LC3) and ubiquitin, resulting in the recruitment of IFN-inducible GTPases.	ros	109-112	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	283-286
28601517-5	2017	Cu pre-acclimation triggered the up-regulation of both enzyme activities and express levels of iNOS and COX-2 in spleen under 420mug CuL-1 exposure, resulting in remarkable reduction of Cu content and ROS in this tissue.	ros	201-204	cullin-1	Larimichthys crocea	133-138
28078487-0	2017	The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.	ros	29-32	NADPH oxidase 4	Rattus norvegicus	16-20
28078487-0	2017	The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia.	ros	29-32	ras homolog family member A	Rattus norvegicus	42-46
28078487-6	2017	OBJECTIVE: This study aimed to investigate the role of the NADPH oxidase 4 (Nox4)-induced ROS/RhoA/ROCK pathway in CIH-induced hypertension in rats.	ros	90-93	NADPH oxidase 4	Rattus norvegicus	59-74
28078487-6	2017	OBJECTIVE: This study aimed to investigate the role of the NADPH oxidase 4 (Nox4)-induced ROS/RhoA/ROCK pathway in CIH-induced hypertension in rats.	ros	90-93	NADPH oxidase 4	Rattus norvegicus	76-80
28078487-6	2017	OBJECTIVE: This study aimed to investigate the role of the NADPH oxidase 4 (Nox4)-induced ROS/RhoA/ROCK pathway in CIH-induced hypertension in rats.	ros	90-93	ras homolog family member A	Rattus norvegicus	94-98
28078487-15	2017	Inhibiting Nox4 activity or ROS production reduced RhoA/ROCK expression.	ros	28-31	ras homolog family member A	Rattus norvegicus	51-55
28078487-18	2017	The CIH-induced elevation of BP is at least partially mediated via the Nox4-induced ROS/RhoA/ROCK pathway.	ros	84-87	NADPH oxidase 4	Rattus norvegicus	71-75
28078487-18	2017	The CIH-induced elevation of BP is at least partially mediated via the Nox4-induced ROS/RhoA/ROCK pathway.	ros	84-87	ras homolog family member A	Rattus norvegicus	88-92
28860481-8	2017	In conclusion, Siglec-9 was complementarily increased to induce a negative feedback loop to limit neutrophil activation in COPD, sSiglce-9 enhanced neutrophil ROS and chemotaxis toward IL-8 likely via competitively inhibiting ligands binding to Siglec-9.	ros	159-162	sialic acid binding Ig like lectin 9	Homo sapiens	15-23
28861171-5	2017	Moreover, CAA potently induced cell cycle arrest at G2/M phase and apoptosis with the increased intracellular reactive oxidative species (ROS) level.	ros	138-141	teashirt zinc finger homeobox 1	Homo sapiens	10-13
28861171-6	2017	Inhibition of ROS could partially rescue CAA-induced cell apoptosis.	ros	14-17	teashirt zinc finger homeobox 1	Homo sapiens	41-44
28641152-5	2017	Urea-induced ROS reduced the number of endothelial cell colony forming units, uptake and binding of Dil-Ac-LDL and lectin-1, and the ability to differentiate into CD31- and vascular endothelial growth factor receptor 2-positive cells.	ros	13-16	kinase insert domain receptor	Homo sapiens	173-218
28292711-4	2017	Ang II significantly up-regulated MMP-9 expression and cell migration of HASMCs, which was inhibited by transfection with siRNA of p47phox, Nox2, Nox4, p65, angiotensin II type 1 receptor (AT1R) and pretreatment with the inhibitors of NADPH oxidase, ROS, and NF-kappaB.	ros	250-253	matrix metallopeptidase 9	Homo sapiens	34-39
28292711-4	2017	Ang II significantly up-regulated MMP-9 expression and cell migration of HASMCs, which was inhibited by transfection with siRNA of p47phox, Nox2, Nox4, p65, angiotensin II type 1 receptor (AT1R) and pretreatment with the inhibitors of NADPH oxidase, ROS, and NF-kappaB.	ros	250-253	neutrophil cytosolic factor 1	Homo sapiens	131-138
28652417-3	2017	K-ras fulfills the criteria of the oncogene-induced DNA damage model, as it can provoke well-established causes for inactivating tumor-suppressors, i.e. DNA double-strand breaks (causing allele deletion) and ROS production (responsible for point mutation).	ros	208-211	KRAS proto-oncogene, GTPase	Homo sapiens	0-5
27167127-5	2017	Fat-1 mice with high endogenous omega-3 PUFAs significantly inhibited ROS expression and attenuated parenchymal cell death after compression injury during the early injury phase.	ros	70-73	FAT atypical cadherin 1	Mus musculus	0-5
28384544-2	2017	Systematic structure-activity relationship study revealed that hydroxyl group in C-5, C-6, or C-7 position of indanone moiety, and ortho-, meta-, or para-fluorine, trifluoromethyl, trifluoromethoxy, and bromine functionalities in phenyl ring are important for inhibition of ROS production in LPS-stimulated RAW 264.7 macrophages.	ros	274-277	complement C7	Homo sapiens	94-97
28642708-7	2017	Further mechanistic investigation revealed that 17-AAG, a pharmacologic inhibitor of Hsp90, significantly blocked the myricitrin-induced cardioprotective effect demonstrated by increased apoptosis and ROS generation.	ros	201-204	N-methylpurine DNA glycosylase	Homo sapiens	51-54
28612710-10	2017	In addition, YC-1 increased the activities of caspase-9 and caspase-3, disrupted the mitochondrial membrane potential (AYm) and stimulated ROS production in CAR cells.	ros	139-142	RNA binding motif single stranded interacting protein 1	Homo sapiens	13-17
28566714-6	2017	ROS production and MMP was significantly suppressed by DPI addition and deletion of NDE1.	ros	0-3	NADH-ubiquinone reductase (H(+)-translocating) NDE1	Saccharomyces cerevisiae S288C	84-88
28566714-8	2017	The results obtained suggest that the functioning of mitochondrial flavin-binding enzymes, Nde1p for instance, is required for the hyperpolarization of inner mitochondrial membrane and ROS production in respiring S. cerevisiae cells under heat-shock conditions.	ros	185-188	NADH-ubiquinone reductase (H(+)-translocating) NDE1	Saccharomyces cerevisiae S288C	91-96
29029419-8	2017	In addition, CD44 inhibitor could decrease glucose consumption and increase ROS levels of PC-3 cells significantly, as well as sensitize PC-3 cells to docetaxel.	ros	76-79	CD44 molecule (Indian blood group)	Homo sapiens	13-17
28373366-0	2017	Correction: ROS-Induced CXCR4 Signaling Regulates Mantle Cell Lymphoma (MCL) Cell Survival and Drug Resistance in the Bone Marrow Microenvironment via Autophagy.	ros	12-15	C-X-C motif chemokine receptor 4	Homo sapiens	24-29
27721403-5	2017	Subsequently, we demonstrated that CD45+CD33+CD11b+HLA-DR- MDSCs from fresh BC tissues displayed high levels of suppressive molecules, including Arg1, iNOS, ROS, PDL-1 and P-STAT3, and stronger suppression of T-cell proliferation.	ros	157-160	protein tyrosine phosphatase receptor type C	Homo sapiens	35-39
27721403-5	2017	Subsequently, we demonstrated that CD45+CD33+CD11b+HLA-DR- MDSCs from fresh BC tissues displayed high levels of suppressive molecules, including Arg1, iNOS, ROS, PDL-1 and P-STAT3, and stronger suppression of T-cell proliferation.	ros	157-160	integrin subunit alpha M	Homo sapiens	45-50
27912197-7	2017	Rac1 activation mediates NADPH oxidase (NOX) activation leading to elevated ROS production in both cells.	ros	76-79	Rac family small GTPase 1	Homo sapiens	0-4
28063381-8	2017	Consistently, Nox4-mediated ROS generation and fibrotic gene expression were attenuated upon Brd4 inhibition.	ros	28-31	NADPH oxidase 4	Rattus norvegicus	14-18
28063381-8	2017	Consistently, Nox4-mediated ROS generation and fibrotic gene expression were attenuated upon Brd4 inhibition.	ros	28-31	bromodomain containing 4	Rattus norvegicus	93-97
28063381-11	2017	In conclusion, these results indicated that the inhibition of Brd4 might protect against renal fibrosis by blocking the TGF-beta-Nox4-ROS-fibrosis axis, suggesting that Brd4 could be a promising therapeutic target.	ros	134-137	bromodomain containing 4	Rattus norvegicus	62-66
28063381-11	2017	In conclusion, these results indicated that the inhibition of Brd4 might protect against renal fibrosis by blocking the TGF-beta-Nox4-ROS-fibrosis axis, suggesting that Brd4 could be a promising therapeutic target.	ros	134-137	NADPH oxidase 4	Rattus norvegicus	129-133
28063381-11	2017	In conclusion, these results indicated that the inhibition of Brd4 might protect against renal fibrosis by blocking the TGF-beta-Nox4-ROS-fibrosis axis, suggesting that Brd4 could be a promising therapeutic target.	ros	134-137	bromodomain containing 4	Rattus norvegicus	169-173
28359291-10	2017	We found that curcumin induced POLG depletion via ROS generation, and POLG knockdown also reduced oxidative phosphorylation (OXPHOS) activity and cellular glycolytic rate which was partially rescued by ROS scavenger NAC, indiating POLG plays an important role in the treatment of gastric cancer.	ros	202-205	polymerase (DNA directed), gamma	Mus musculus	70-74
28359291-10	2017	We found that curcumin induced POLG depletion via ROS generation, and POLG knockdown also reduced oxidative phosphorylation (OXPHOS) activity and cellular glycolytic rate which was partially rescued by ROS scavenger NAC, indiating POLG plays an important role in the treatment of gastric cancer.	ros	202-205	polymerase (DNA directed), gamma	Mus musculus	70-74
28359291-13	2017	CONCLUSIONS: Together, our data suggest a novel mechanism by which curcumin inhibited gastric tumor growth through excessive ROS generation, resulting in depletion of POLG and mtDNA, and the subsequent disruption of cellular bioenergetics.	ros	125-128	polymerase (DNA directed), gamma	Mus musculus	167-171
28358377-6	2017	Tumor necrosis factor receptor-associated protein 1 (TRAP1) overexpression in BAY-treated cells lowered ROS levels and inhibited mPTP opening and cell death, whereas the latter was potentiated by TRAP1 knockdown.	ros	104-107	TNF receptor associated protein 1	Homo sapiens	0-51
28358377-6	2017	Tumor necrosis factor receptor-associated protein 1 (TRAP1) overexpression in BAY-treated cells lowered ROS levels and inhibited mPTP opening and cell death, whereas the latter was potentiated by TRAP1 knockdown.	ros	104-107	TNF receptor associated protein 1	Homo sapiens	53-58
28287688-7	2017	Finally, as a photosensitizer, PPET3-N2 can efficiently generate singlet oxygen in living cells upon irradiation of white light, leading to the destruction of lysosome membrane and release of ROS and lysosomal enzymes in cytoplasma, causing cell death.	ros	192-195	endothelin 3	Homo sapiens	31-36
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	ros	49-52	transient receptor potential cation channel subfamily M member 2	Homo sapiens	128-133
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	ros	49-52	transient receptor potential cation channel subfamily M member 2	Homo sapiens	158-163
28322340-7	2017	Taken together, our study shows PKC/NOX-mediated ROS generation and PARP-1 activation as an important mechanism in Zn2+-induced TRPM2 channel activation and, TRPM2-mediated increase in the [Ca2+]c to trigger the PYK2/MEK/ERK signalling pathway as a positive feedback mechanism that amplifies the TRPM2 channel activation.	ros	49-52	transient receptor potential cation channel subfamily M member 2	Homo sapiens	158-163
28247072-0	2017	Erratum to: Encapsulated Hsp70 decreases endotoxin-induced production of ROS and TNFalpha in human phagocytes.	ros	73-76	heat shock protein family A (Hsp70) member 4	Homo sapiens	25-30
27995612-8	2017	IL-15 and IL-6 expression are stimulated by IFN-y and correlate with ROS levels in BM mononuclear cells.	ros	69-72	interleukin 15	Homo sapiens	0-5
28069524-0	2017	ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway.	ros	91-94	autophagy related 14	Homo sapiens	0-5
28119081-7	2017	Results from this study showed that DSP administration effectively ameliorated Abeta-induced learning and memory impairment in rats, markedly inhibited Abeta-induced hippocampal ROS production, effectively prevented Abeta-induced hippocampal neuronal damage and significantly restored hippocampal synaptophysin expression level.	ros	178-181	amyloid beta precursor protein	Rattus norvegicus	152-157
28119081-7	2017	Results from this study showed that DSP administration effectively ameliorated Abeta-induced learning and memory impairment in rats, markedly inhibited Abeta-induced hippocampal ROS production, effectively prevented Abeta-induced hippocampal neuronal damage and significantly restored hippocampal synaptophysin expression level.	ros	178-181	amyloid beta precursor protein	Rattus norvegicus	152-157
28435452-3	2017	Mechanistically, increased KRAS expression induced ROS production, which elevated HIF-1alpha and YAP1 expression.	ros	51-54	KRAS proto-oncogene, GTPase	Homo sapiens	27-31
28176763-2	2017	Here, we show that a signalling network of p190-B RhoGAP-ROS-TGF-beta-p38MAPK balances HSPC self-renewal and differentiation.	ros	57-60	Rho GTPase activating protein 1	Homo sapiens	50-56
27890624-3	2017	In the present work we report a network among OPA1, Sirt3 and cAMP in ROS-dependent apoptosis.	ros	70-73	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	46-50
27923567-7	2017	qRT-PCR studies revealed that both membrane efflux channels such as acrAB as well as ROS scavenger genes such as ahpCF have been activated by engineering crp.	ros	85-88	catabolite gene activator protein	Escherichia coli	154-157
28139737-6	2017	These results establish a novel mechanism by which NF-kappaB and Akt contribute to chemoresistance involving a signaling pathway consisting of histone H4, DNA-PK, RIP1 and IAPs that attenuates ROS-mediated apoptosis, and targeting this pathway may improve the anticancer efficacy of platinum-based chemotherapy.	ros	193-196	H4 clustered histone 9	Homo sapiens	143-153
28011270-2	2017	A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibiting the NADPH oxidase 4 (Nox4)-ROS signaling in the heart.	ros	143-146	NADPH oxidase 4	Rattus norvegicus	120-135
28011270-2	2017	A recent study showed that hydrogen sulfide (H2S) may modulate the effects of angiotensin II (Ang II) by inhibiting the NADPH oxidase 4 (Nox4)-ROS signaling in the heart.	ros	143-146	NADPH oxidase 4	Rattus norvegicus	137-141
28088182-0	2017	Overexpression of wheat ferritin gene TaFER-5B enhances tolerance to heat stress and other abiotic stresses associated with the ROS scavenging.	ros	128-131	Fer2	Triticum aestivum	24-32
11179740-10	2001	Using a Western procedure, it was also shown that 1alpha,24(S)(OH)(2)D(2) like 1alpha,25(OH)(2)D(3) enhances the expression of vitamin D receptors (VDR) in the rat osteosarcoma cell line, ROS 17/2.8.	ros	188-191	vitamin D receptor	Rattus norvegicus	148-151
10960016-8	2000	Gene expression for ALPase, osteocalcin bone sialoprotein, osteopontin, and BMP-7 at mRNA message was detected by RT-PCR in hPF and ROS 17/2.8 cells.	ros	132-135	bone morphogenetic protein 7	Rattus norvegicus	76-81
9888789-8	1999	In addition, on the basis of the established modulatory features of ROS-GC1, it is predicted that, in two other forms of LCA1 involving deletion of nt 460C or 693C, there is a frameshift in ROS-GC1 gene, which results in the nonexpression of the cyclase.	ros	68-71	guanylate cyclase 2D, retinal	Homo sapiens	121-125
9888789-8	1999	In addition, on the basis of the established modulatory features of ROS-GC1, it is predicted that, in two other forms of LCA1 involving deletion of nt 460C or 693C, there is a frameshift in ROS-GC1 gene, which results in the nonexpression of the cyclase.	ros	68-71	solute carrier family 25 member 22	Homo sapiens	72-75
9831079-4	1998	Furthermore, treatment of ROS 17/2.8 osteosarcoma cells with the proteasome inhibitors MG132 or beta-lactone increased steady-state levels of the VDR protein.	ros	26-29	vitamin D receptor	Rattus norvegicus	146-149
9613602-5	1998	CD-GCAP is a Ca2+-binding protein and is a specific activator of one of the two members of the ROS-GC subfamily of membrane guanylate cyclases, ROS-GC1.	ros	95-98	guanylate cyclase 2D, retinal	Homo sapiens	144-151
9613602-8	1998	The findings demonstrate the existence of a novel signal transduction mechanism--the linkage of the alpha(2D/A)-AR signaling system with ROS-GC1 transduction system, occurring through intracellular Ca2+ via CD-GCAP.	ros	137-140	solute carrier family 25 member 22	Homo sapiens	141-144
25448048-11	2014	Moreover, blockage of p53 activities with PFT-alpha and PFT-mu significantly attenuated Mn-induced reactive oxidative stress (ROS) generation and mitochondrial H2O2 production.	ros	126-129	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	22-25
25451262-3	2014	beta-Lap significantly restored energy production and mitochondrial membrane potential as well as normalized the elevated ROS level in MELAS cybrid cells.	ros	122-125	LAP	Homo sapiens	5-8
25065405-0	2014	Mitochondrial dynamics regulate melanogenesis through proteasomal degradation of MITF via ROS-ERK activation.	ros	90-93	melanocyte inducing transcription factor	Homo sapiens	81-85
25270604-15	2014	CONCLUSION: MG elicits SGK1-dependent activation of endothelial Na+/H+ exchanger NHE1 which participates in MG-induced ROS production, upregulation of endothelial ICAM-1, leukocyte recruitment and microvascular hyperpermeability.	ros	119-122	serum/glucocorticoid regulated kinase 1	Mus musculus	23-27
25136835-14	2014	ROS inhibition markedly decreased nuclear factor-kB (NF-kB) phosphorylation, thioredoxin interacting/inhibiting protein (TXNIP), NLRP3 inflammasome, and mature IL-1beta in high glucose treated H9c2 cells.	ros	0-3	nuclear factor kappa B subunit 1	Rattus norvegicus	53-58
25090023-8	2014	Our results showed that PCB-induced ROS mediated a highly tube branched neovascular phenotype that also depended on ID3 and Pyk2; and PCB153 treatment increased the size of endothelial spheroids under conditions typically used for clonal selection of stem cell spheroids.	ros	36-39	protein tyrosine kinase 2 beta	Homo sapiens	124-128
24823440-0	2014	Ruthenium polypyridyl complexes as inducer of ROS-mediated apoptosis in cancer cells by targeting thioredoxin reductase.	ros	46-49	peroxiredoxin 5	Homo sapiens	98-119
25071437-9	2014	Section ROS-GC1 Gene Linked Retinal Dystrophies demonstrates how this knowledge begins to be translated into the diagnosis and providing the molecular definition of retinal dystrophies.	ros	8-11	solute carrier family 25 member 22	Homo sapiens	12-15
24727215-1	2014	The major thiol-containing molecules involved in controlling the level of intracellular ROS in eukaryotes, acting as a nonenzymatic detoxification system, are metallothioneins (MTs), glutathione (GSH) and phytochelatins (PCs).	ros	88-91	Glutathione gamma-glutamylcysteinyltransferase	Caenorhabditis elegans	221-224
24569053-9	2014	Cysteine-39 of the ND3 subunit, exposed in the D-form, is susceptible to covalent modification by nitrosothiols, ROS and RNS.	ros	113-116	mitochondrially encoded NADH dehydrogenase 3	Homo sapiens	19-22
24865426-3	2014	Here, we found that MAOA functions to induce epithelial-to-mesenchymal transition (EMT) and stabilize the transcription factor HIF1alpha, which mediates hypoxia through an elevation of ROS, thus enhancing growth, invasiveness, and metastasis of PCa cells.	ros	185-188	monoamine oxidase A	Homo sapiens	20-24
24682522-0	2014	Cosuppression of RBCS3B in Arabidopsis leads to severe photoinhibition caused by ROS accumulation.	ros	81-84	Ribulose bisphosphate carboxylase (small chain) family protein	Arabidopsis thaliana	17-23
24682522-1	2014	KEY MESSAGE: Cosuppression of an Arabidopsis Rubisco small subunit gene RBCS3B at Arabidopsis resulted in albino or pale green phenotypes which were caused by ROS accumulation As the most abundant protein on Earth, Rubisco has received much attention in the past decades.	ros	159-162	Ribulose bisphosphate carboxylase (small chain) family protein	Arabidopsis thaliana	72-78
24682522-8	2014	We found that photoinhibition was due to accumulation of ROS, which accelerated photodamage of PSII and inhibited the repair of PSII in RBCS3B-7.	ros	57-60	Ribulose bisphosphate carboxylase (small chain) family protein	Arabidopsis thaliana	136-142
24412329-9	2014	Transduced PEP-1-PEA-15 protected against MPP(+)-induced toxicity by inhibiting intracellular ROS levels and DNA fragmentation.	ros	94-97	CNDP dipeptidase 2 (metallopeptidase M20 family)	Mus musculus	11-16
24412329-9	2014	Transduced PEP-1-PEA-15 protected against MPP(+)-induced toxicity by inhibiting intracellular ROS levels and DNA fragmentation.	ros	94-97	proliferation and apoptosis adaptor protein 15A	Mus musculus	17-23
24762438-7	2014	We revealed that loss of FLCN constitutively activates AMPK, resulting in PGC-1alpha-mediated mitochondrial biogenesis and increased ROS production.	ros	133-136	folliculin	Homo sapiens	25-29
24662377-8	2014	The ROS, MDA and GSH accumulation was significantly affected in the mutant gsh1, gr1 and gpx2 after treatment with OTA, which indicated that glutathione metabolism is directly involved in the oxidative stress response of Arabidopsis thaliana subjected to OTA.	ros	4-7	glutamate-cysteine ligase	Arabidopsis thaliana	75-79
24662377-8	2014	The ROS, MDA and GSH accumulation was significantly affected in the mutant gsh1, gr1 and gpx2 after treatment with OTA, which indicated that glutathione metabolism is directly involved in the oxidative stress response of Arabidopsis thaliana subjected to OTA.	ros	4-7	glutathione peroxidase 2	Arabidopsis thaliana	89-93
24657139-9	2014	After NIR exposed, the MC540 was activated to produce singlet oxygen (ROS) successfully by the upconverting fluorescence emitted from UCN.	ros	70-73	urocortin	Homo sapiens	134-137
24810628-9	2014	Isolated heart mitochondrial studies showed significantly altered O2-consumption, ROS production, matrix calcium, and mitochondrial membrane potential in miR-181c-treated animals.	ros	82-85	microRNA 181c	Rattus norvegicus	154-162
24415791-0	2014	Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases.	ros	134-137	phosphohistidine phosphatase 1	Mus musculus	48-50
24415791-10	2014	These data indicate that Hvcn1 ablation deregulates neutrophil pHp, leading to alkalinization in phagosomes with residual ROS production or to the early accumulation of V-ATPase on phagosomes that fail to mount an oxidative response.	ros	122-125	phosphohistidine phosphatase 1	Mus musculus	63-66
24360748-5	2014	(2) Downregulation of FFAR1 expression reduced the attenuating effect of PIO on the expression of NAPDH oxidase subunit p47(phox), Bax, cleaved caspase 3, and the production of reactive oxygen specific (ROS) induced by lipotoxicity, thereby preventing the upregulation of the expression of bcl-2.	ros	203-206	free fatty acid receptor 1	Mus musculus	22-27
24423925-6	2014	ROS induced by RRM2 in cercal cancer cells was confirmed by flow cytometry.	ros	0-3	ribonucleotide reductase regulatory subunit M2	Homo sapiens	15-19
24423925-12	2014	RRM2-activated ERK1/2 pathway was mediated through production of ROS.	ros	65-68	ribonucleotide reductase regulatory subunit M2	Homo sapiens	0-4
24423925-14	2014	CONCLUSION: HPVE7 induces upregulation of RRM2, which then promotes cervical carcinogenesis via ROS-ERK1/2-HIF-1alpha-VEGF-induced angiogenesis.	ros	96-99	ribonucleotide reductase regulatory subunit M2	Homo sapiens	42-46
24669277-11	2014	Lucigenin chemiluminescence, DHE and TUNEL staining demonstrated that BMSCs-ecSOD delivery reduced ROS level and cell apoptosis both in vivo and in vitro.	ros	99-102	superoxide dismutase 3, extracellular	Mus musculus	76-81
23892647-7	2014	The activation of eIF2alpha, ATF4 and ATF6 and expression of GRP78 and CHOP are repressed by both LA and tiron, indicating arsenic-induced UPR is mediated through ROS-dependent and ROS-independent pathways.	ros	163-166	DNA-damage inducible transcript 3	Mus musculus	71-75
24252613-15	2014	Together, these data suggest that pro-inflammatory cytokines induce the formation of ROS and NO, which, through the formation of peroxynitrite, reduce the Hsp27 content and bring about apoptosis of retinal capillary endothelial cells.	ros	85-88	heat shock protein family B (small) member 1	Homo sapiens	155-160
9618801-3	1998	In particular, ROS.SMER #14 osteoblastic cells, stably transfected with the mouse ER, undergo specific morphological changes in vitro.	ros	15-18	estrogen receptor 1 (alpha)	Mus musculus	21-23
9793175-2	1998	It has been recently shown that the osteocalcin gene promoter binds specifically two proteins, NMP-1 and NMP-2 (nuclear matrix proteins 1 and 2), from cell line ROS 17/2.8 (Bidwell et al., 1993).	ros	161-164	RAD21 cohesin complex component	Homo sapiens	112-143
9793175-5	1998	Among the nuclear matrix proteins of ROS 17/2.8 we have found a protein factor which binds the promoter region of the osteopontin gene specifically with the help of gel shift assay.	ros	37-40	secreted phosphoprotein 1	Homo sapiens	118-129
9322974-4	1997	Expression of ERbeta mRNA was evident in primary osteoblastic cells isolated from 1-day-old rat calvaria and rat osteosarcoma cells (ROS 17/2.8), and its level was higher than that of ER alpha mRNA.	ros	133-136	estrogen receptor 2	Rattus norvegicus	14-20
9306258-3	1997	Primary osteoblast and ROS 17/2.8 cells released NO upon stimulation of interleukin-1 beta, tumour necrosis factor-alpha, and interferon-gamma.	ros	23-26	interferon gamma	Rattus norvegicus	126-142
9212060-13	1997	Dominant negative Ras abrogates MMP1 induction by constitutively active FGFR2-ROS, but dominant negative Rho and Rac do not inhibit induction.	ros	78-81	matrix metallopeptidase 1	Homo sapiens	32-36
9212060-13	1997	Dominant negative Ras abrogates MMP1 induction by constitutively active FGFR2-ROS, but dominant negative Rho and Rac do not inhibit induction.	ros	78-81	fibroblast growth factor receptor 2	Homo sapiens	72-77
9027729-2	1997	Recently, ROS have been shown to suppress the in vitro synthesis of erythropoietin (Epo).	ros	10-13	erythropoietin	Rattus norvegicus	68-82
9027729-2	1997	Recently, ROS have been shown to suppress the in vitro synthesis of erythropoietin (Epo).	ros	10-13	erythropoietin	Rattus norvegicus	84-87
8634257-4	1996	We have characterized the hydrodynamic properties of Triton X-100 solubilized peripherin/rds-rom-1 complexes from bovine ROS membranes by gel exclusion chromatography on Sepharose C1-6B and velocity sedimentation through H2O- and D2O-based sucrose gradients.	ros	121-124	retinal outer segment membrane protein 1	Bos taurus	93-98
8634257-8	1996	The abundance of this complex as measured by competitive ELISA and immunoaffinity purification is approximately 4% of total bovine ROS membrane protein and indicates that peripherin/rds-rom-1 tetramers are present at a relatively high average surface density (ca.	ros	131-134	retinal outer segment membrane protein 1	Bos taurus	186-191
8612541-7	1996	Gel mobility shift assays show that TGF beta significantly reduces induction of the heterodimers VDR/RXR complexes in 1,25-(OH)2D3-treated ROS 17/2.8 cells.	ros	139-142	vitamin D receptor	Rattus norvegicus	97-100
8264662-1	1993	A regulatory mechanism for the vitamin D receptor (VDR) in rat osteosarcoma cells (ROS 17/2.8) is stabilization of the receptor through binding of its ligand, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].	ros	83-86	vitamin D receptor	Rattus norvegicus	31-49
8264662-1	1993	A regulatory mechanism for the vitamin D receptor (VDR) in rat osteosarcoma cells (ROS 17/2.8) is stabilization of the receptor through binding of its ligand, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3].	ros	83-86	vitamin D receptor	Rattus norvegicus	51-54
8247015-1	1993	The osteoblast-like osteosarcoma cell line ROS 17/2.8, which expresses very low levels of estrogen receptor (ER), was stably transfected with the mouse ER in order to more easily evaluate the physiological role of estrogens in bone cell homeostasis.	ros	43-46	estrogen receptor 1 (alpha)	Mus musculus	90-107
8247015-1	1993	The osteoblast-like osteosarcoma cell line ROS 17/2.8, which expresses very low levels of estrogen receptor (ER), was stably transfected with the mouse ER in order to more easily evaluate the physiological role of estrogens in bone cell homeostasis.	ros	43-46	estrogen receptor 1 (alpha)	Mus musculus	109-111
8394128-2	1993	When ROS 17/2.8 cells are labeled metabolically with [35S]methionine, treatment with 10(-8) M 1,25(OH)2D3 elicits a decrease in the electrophoretic mobility of immunoprecipitated VDR in denaturing polyacrylamide gels, a property characteristic of phosphorylated proteins.	ros	5-8	vitamin D receptor	Rattus norvegicus	179-182
8394128-3	1993	Similar labeling of cells with [32P]orthophosphate results in a rapid (&lt; or = 30 min), 1,25(OH)2D3-dependent incorporation of 32P into a 54-kDa VDR species that comigrates with the slower migrating receptor species extracted from [35S]methionine-labeled ROS 17/2.8 cells that have been exposed to 1,25(OH)2D3.	ros	257-260	vitamin D receptor	Rattus norvegicus	147-150
8394128-5	1993	Incubation of ROS 17/2.8 cells with the non-hypercalcemic 1,25(OH)2D3 analog, 22-oxacalcitriol (OCT), produces a level of VDR phosphorylation similar to that elicited by 1,25(OH)2D3 treatment.	ros	14-17	vitamin D receptor	Rattus norvegicus	122-125
1321435-2	1992	Protein-DNA interactions at the VDRE of the rat OC gene (nucleotides -466 to -437) are reflected by direct sequence-specific and antibody-sensitive binding of the endogenous vitamin D receptor present in ROS 17/2.8 osteosarcoma nuclear protein extracts.	ros	204-207	vitamin D receptor	Rattus norvegicus	174-192
28097237-1	2017	Oxidation of calmodulin-dependent protein kinase II (ox-CaMKII) by ROS has been associated with asthma.	ros	67-70	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	56-62
27729002-9	2017	Downregulation of miR-30 increased ROS generation which was inhibited by shP53.	ros	35-38	membrane associated ring-CH-type finger 8	Homo sapiens	18-21
27729002-12	2017	In conclusion, we identified that miR-30 functioned as a potential oncomiR through P53/ROS-mediated regulation of mitochondrial apoptotic pathway.	ros	87-90	membrane associated ring-CH-type finger 8	Homo sapiens	34-37
29147462-0	2017	Oxygen-Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF-kappaB Pathways.	ros	40-43	NADPH oxidase 4	Rattus norvegicus	15-19
29147462-5	2017	Consequently, ROS induced by 20% O2 caused DNA damage and then activated p53-p21-Rb and p16-Rb pathways via ERK signaling to induce NP cell senescence.	ros	14-17	KRAS proto-oncogene, GTPase	Rattus norvegicus	77-80
29147462-5	2017	Consequently, ROS induced by 20% O2 caused DNA damage and then activated p53-p21-Rb and p16-Rb pathways via ERK signaling to induce NP cell senescence.	ros	14-17	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	88-91
29147462-8	2017	Small interfering RNA against Nox4 reduced ROS production induced by 20% O2 and consequently suppressed premature senescence of NP cells.	ros	43-46	NADPH oxidase 4	Rattus norvegicus	30-34
29147462-9	2017	On the contrary, NP cells overexpressing Nox4 produced more ROS and rapidly developed senescent signs.	ros	60-63	NADPH oxidase 4	Rattus norvegicus	41-45
29147462-11	2017	This study, for the first time, demonstrates that Nox4 is an oxygen-sensing enzyme and a main ROS source in NP cells.	ros	94-97	NADPH oxidase 4	Rattus norvegicus	50-54
29147462-12	2017	Nox4-dependent ROS are genotoxic and a potent trigger of NP cell senescence.	ros	15-18	NADPH oxidase 4	Rattus norvegicus	0-4
29213350-8	2017	Overexpression of IEX-1 in neonatal rat cardiomyocytes significantly reduced hypoxia-reoxygenation-induced intracellular and mitochondrial ROS accumulation and cell apoptosis.	ros	139-142	immediate early response 3	Rattus norvegicus	18-23
29213350-10	2017	Our results demonstrate that IPC increases IEX-1 expression, which may promote phosphorylation and particle translocation of PKCepsilon and thus reduce intracellular ROS accumulation.	ros	166-169	immediate early response 3	Rattus norvegicus	43-48
27974211-4	2016	Ablating both Shp2 and Pten in hepatocytes induced early-onset non-alcoholic steatohepatitis (NASH) and promoted genesis of liver tumor-initiating cells likely due to augmented cJun expression/activation and elevated ROS and inflammation in the hepatic microenvironment.	ros	217-220	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	14-18
27787644-10	2016	Pretreatment with NAC, a ROS scavenger, abrogated the EF24-induced cell death, apoptosis, cell cycle arrest, and mitochondrial dysfunction, suggesting an upstream ROS generation which was responsible for the anticancer effects of EF24.	ros	25-28	X-linked Kx blood group	Homo sapiens	18-21
27787644-10	2016	Pretreatment with NAC, a ROS scavenger, abrogated the EF24-induced cell death, apoptosis, cell cycle arrest, and mitochondrial dysfunction, suggesting an upstream ROS generation which was responsible for the anticancer effects of EF24.	ros	163-166	X-linked Kx blood group	Homo sapiens	18-21
27376435-0	2016	Methylphenidate-triggered ROS generation promotes caveolae-mediated transcytosis via Rac1 signaling and c-Src-dependent caveolin-1 phosphorylation in human brain endothelial cells.	ros	26-29	Rac family small GTPase 1	Homo sapiens	85-89
27376435-5	2016	Using FRET-based live cell imaging, together with pharmacological inhibitors and lentiviral-mediated shRNA knockdown, we demonstrate that MPH promoted ROS generation via activation of Rac1-dependent NADPH oxidase (NOX) and c-Src activation at the plasma membrane.	ros	151-154	Rac family small GTPase 1	Homo sapiens	184-188
26785383-4	2016	Data indicate that DDSD induced the generation of ROS, consequentially caused alteration in Bax/Bcl-2 ratio that disrupted the inner mitochondrial transmembrane potential (DeltaPsim) resulting in cytochrome c redistribution to the cytoplasm and activation of caspase-mediated apoptotic pathway.	ros	50-53	BCL2-associated X protein	Mus musculus	92-95
27638049-4	2016	Following ATO treatment, ATF4 activates NADPH oxidase by promoting assembly of the enzyme components Rac-1/P47phox/P67phox, which generates ROS/superoxides.	ros	140-143	activating transcription factor 4	Homo sapiens	25-29
27638049-4	2016	Following ATO treatment, ATF4 activates NADPH oxidase by promoting assembly of the enzyme components Rac-1/P47phox/P67phox, which generates ROS/superoxides.	ros	140-143	Rac family small GTPase 1	Homo sapiens	101-106
27638049-4	2016	Following ATO treatment, ATF4 activates NADPH oxidase by promoting assembly of the enzyme components Rac-1/P47phox/P67phox, which generates ROS/superoxides.	ros	140-143	neutrophil cytosolic factor 1	Homo sapiens	107-114
27276511-4	2016	RESULTS: Metformin and resveratrol inhibited ROS-associated mitochondrial fission by upregulating Drp1 phosphorylation (Ser 637) in an AMPK-dependent manner, and then suppressed ER stress indicated by dephosphorylation of IRE1alpha and eIF2alpha in the adipose tissue.	ros	45-48	collapsin response mediator protein 1	Mus musculus	98-102
27729006-14	2016	GO functional category and KEGG enrichment analysis of DEGs indicated that gene activities related to stress and ROS were altered between the two cultivars in both flesh and peel tissues.	ros	113-116	delta 4-desaturase, sphingolipid 1	Homo sapiens	55-59
27416558-7	2016	RESULTS: Our results provide experimental evidence that PG inhibits growth and suppresses invasion of HCC cells by downregulating DNMT1 via ROS-dependent AMP-activated protein kinase (AMPK)-mediated modulation of transcription factor Sp1.	ros	140-143	DNA methyltransferase 1	Homo sapiens	130-135
27586257-5	2016	HSF4 and alpha B-crystallin can selectively protect lens epithelial cells from cisplatin and H2O2 induced apoptosis by stabilizing mitochondrial membrane potential (DeltaYm) and reducing ROS production.	ros	187-190	heat shock transcription factor 4	Mus musculus	0-4
27484784-0	2016	Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.	ros	201-204	activating transcription factor 3	Rattus norvegicus	41-45
27392709-7	2016	Furthermore, ox-LDL treatment resulted in significant increases of ROS and MDA but a marked decrease of SOD, effects that were reversed by Lp-PLA2 silencing in THP1 cells.	ros	67-70	phospholipase A2 group VII	Homo sapiens	139-146
27582555-8	2016	ROS scavengers (N-acetyl-L-cysteine, NAC, and glutathione, GSH) also blocked the IK-induced ROS production and HO-1 expression.	ros	0-3	NLR family, pyrin domain containing 1A	Mus musculus	37-40
27582555-8	2016	ROS scavengers (N-acetyl-L-cysteine, NAC, and glutathione, GSH) also blocked the IK-induced ROS production and HO-1 expression.	ros	92-95	NLR family, pyrin domain containing 1A	Mus musculus	37-40
27582555-10	2016	In addition, ROS scavengers suppressed other oxidative enzymes such as catalase (CAT), glutathione S-transferase (GST), and NADH quinone oxidoreductase (NQO-1) in IK-treated RAW264.7 cells.	ros	13-16	NAD(P)H dehydrogenase, quinone 1	Mus musculus	153-158
27385725-0	2016	P66Shc, a key regulator of metabolism and mitochondrial ROS production, is dysregulated by mouse embryo culture.	ros	56-59	src homology 2 domain-containing transforming protein C1	Mus musculus	0-6
1664043-6	1991	Analogous chromatography of the VDR derived from ROS 17/2.8 cells treated with 1,25-dihydroxyvitamin D3 in culture also reveals a dual profile of weak and strong binding, suggesting that in vivo modifications are unlikely to alter receptor DNA binding.	ros	49-52	vitamin D receptor	Rattus norvegicus	32-35
24587916-13	2014	Chronic administration of LF strongly reduced the blood pressure and production of ROS and improved antioxidant capacity in Dex-induced hypertension, suggesting the role of inhibition of oxidative stress as another mechanism of antihypertensive action of LF.	ros	83-86	lactotransferrin	Rattus norvegicus	26-28
2115429-2	1990	IFN inhibits collagen and DNA synthesis in cultured rat long bones and osteoblastic ROS 17/2.8 cells, suggesting that the periarticular loss of bone that occurs in inflammatory joint diseases may be due to IFN inhibition of bone formation.	ros	84-87	interferon gamma	Rattus norvegicus	0-3
2171636-7	1990	Compounds D-2 and G had apparent KdS of 1 X 10(-9) M and 0.6 X 10(-9) M, respectively, for their receptors on ROS 17/2.8 cells, which are identical with or similar to that of the underivatized [Tyr36]PTHrP(1-36)amide.	ros	110-113	solute carrier family 3 member 1	Rattus norvegicus	10-13
27449104-0	2016	NADPH: new oxygen for the ROS theory of aging.	ros	26-29	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
27207947-9	2016	Increased expression of caveolin-1 as well as reduced NADPH oxidase-4 expression, ROS generation and TGFbeta signalling were observed and may have mediated the cardioprotective effects of endothelial PTP1B deletion.	ros	82-85	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	200-205
25015733-13	2014	ROS scavenger dissociated TXNIP from NLRP3 and inhibited the activation of NLRP3 inflammasome in the CMECs.	ros	0-3	NLR family, pyrin domain containing 3	Mus musculus	37-42
27151304-0	2016	MCAM, as a novel receptor for S100A8/A9, mediates progression of malignant melanoma through prominent activation of NF-kappaB and ROS formation upon ligand binding.	ros	130-133	melanoma cell adhesion molecule	Homo sapiens	0-4
27151304-9	2016	In this study, we demonstrated that ALCAM and MCAM also function as S100A8/A9 receptors as does RAGE and induce malignant melanoma progression by NF-kappaB activation and ROS formation.	ros	171-174	melanoma cell adhesion molecule	Homo sapiens	46-50
25015733-13	2014	ROS scavenger dissociated TXNIP from NLRP3 and inhibited the activation of NLRP3 inflammasome in the CMECs.	ros	0-3	NLR family, pyrin domain containing 3	Mus musculus	75-80
2330589-0	1990	Lead inhibits the basal and stimulated responses of a rat osteoblast-like cell line ROS 17/2.8 to 1 alpha,25-dihydroxyvitamin D3 and IGF-I.	ros	84-87	insulin-like growth factor 1	Rattus norvegicus	133-138
25162007-9	2014	RESULTS AND CONCLUSION: In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway.	ros	126-129	transformation related protein 53, pseudogene	Mus musculus	134-137
33793303-0	2021	Increased ROS-Mediated CaMKII Activation Contributes to Calcium Handling Abnormalities and Impaired Contraction in Barth Syndrome.	ros	10-13	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	23-29
27033553-6	2016	Real-time quantitative PCR (qRT-PCR) analysis showed that overexpression of AtMYB12 resulted in the up-regulation of genes involved in flavonoid biosynthesis, abscisic acid (ABA) biosynthesis, proline biosynthesis, stress responses and ROS scavenging under salt and drought stresses.	ros	236-239	myb domain protein 12	Arabidopsis thaliana	76-83
27385468-4	2016	Depletion of FOXM1 is sufficient to induce keratinocyte senescence, paralleled by an increased ROS production and an inhibition of ROS-scavenger genes (SOD2, CAT, GPX2, PRDX).	ros	95-98	forkhead box M1	Homo sapiens	13-18
27385468-4	2016	Depletion of FOXM1 is sufficient to induce keratinocyte senescence, paralleled by an increased ROS production and an inhibition of ROS-scavenger genes (SOD2, CAT, GPX2, PRDX).	ros	131-134	forkhead box M1	Homo sapiens	13-18
27385468-6	2016	FOXM1 depletion sensitizes both normal keratinocytes and squamous carcinoma cells to apoptosis and ROS-induced apoptosis.	ros	99-102	forkhead box M1	Homo sapiens	0-5
33793303-8	2021	BTHS iPSC-CMs had higher levels of mitochondrial and cellular ROS than WT, which activated Ca2+/calmodulin-dependent protein kinase II (CaMKII).	ros	62-65	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	91-134
33793303-8	2021	BTHS iPSC-CMs had higher levels of mitochondrial and cellular ROS than WT, which activated Ca2+/calmodulin-dependent protein kinase II (CaMKII).	ros	62-65	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	136-142
25162007-9	2014	RESULTS AND CONCLUSION: In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway.	ros	126-129	caspase 7	Mus musculus	138-147
27181356-4	2016	Arp2/3 complex inhibitor CK666 significantly reduced ox-LDL-induced ROS generation and cytoskeleton reorganization, and increased NO release in HCAECs.	ros	68-71	ARP2 actin-related protein 2	Mus musculus	0-4
23933736-6	2013	Additionally, the decrease in JNK1 phosphorylation observed with Myc knockdown is associated with a reduction in ROS production.	ros	113-116	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	65-68
27124102-7	2016	We further demonstrated that the survival-promoting role of increased mitochondrial fission was mediated via elevated ROS production and subsequent activation of AKT, which facilitated MDM2-mediated TP53 degradation, and NFKBIA- and IKK-mediated transcriptional activity of NFKB in HCC cells.	ros	118-121	MDM2 proto-oncogene	Homo sapiens	185-189
26935109-10	2016	POMC-Ptp1b deletion decreased ROS-scavenging enzymes [superoxide dismutases (SODs)] whereas it increased ROS-generating enzymes [NADPH oxidases (NOXs)] and cyclooxygenase-2 (COX-1) expression, in aorta.	ros	30-33	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	5-10
33771980-0	2021	Elevated TEFM expression promotes growth and metastasis through activation of ROS/ERK signaling in hepatocellular carcinoma.	ros	78-81	transcription elongation factor, mitochondrial	Homo sapiens	9-13
24190484-8	2013	In addition, decreased ROS level indirectly inhibit JNK activation and cell death in CIR rat receiving Remifentanil preconditioning.	ros	23-26	mitogen-activated protein kinase 8	Rattus norvegicus	52-55
33771980-9	2021	Mechanistically, TEFM exerts its tumor growth and metastasis promoting effects at least partly through increasing ROS production and subsequently by activation of ERK signaling.	ros	114-117	transcription elongation factor, mitochondrial	Homo sapiens	17-21
33765263-0	2021	Cadmium induces the thymus apoptosis of pigs through ROS-dependent PTEN/PI3K/AKT signaling pathway.	ros	53-56	phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	Sus scrofa	67-71
27088803-5	2016	Specifically, the authors reveal that CD8+ T cells in close contact with target T cells release NADPH oxidase 2-containing microvesicles that inhibit TCR activation by elevating ROS and thereby reducing phosphorylation of the TCR-associated kinase ZAP70.	ros	178-181	CD8a molecule	Homo sapiens	38-41
27088803-5	2016	Specifically, the authors reveal that CD8+ T cells in close contact with target T cells release NADPH oxidase 2-containing microvesicles that inhibit TCR activation by elevating ROS and thereby reducing phosphorylation of the TCR-associated kinase ZAP70.	ros	178-181	cytochrome b-245 beta chain	Homo sapiens	96-111
27088803-5	2016	Specifically, the authors reveal that CD8+ T cells in close contact with target T cells release NADPH oxidase 2-containing microvesicles that inhibit TCR activation by elevating ROS and thereby reducing phosphorylation of the TCR-associated kinase ZAP70.	ros	178-181	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	248-253
33765263-0	2021	Cadmium induces the thymus apoptosis of pigs through ROS-dependent PTEN/PI3K/AKT signaling pathway.	ros	53-56	AKT serine/threonine kinase 1	Sus scrofa	77-80
24013762-10	2013	The ascorbic acid-deficient mutants (vtc2-1, vtc2-3) possessing slightly elevated ROS levels proved to be Cu sensitive, while miox4 showing decreased ROS production was more tolerant to Cu than the WT.	ros	82-85	GDP-L-galactose phosphorylase 1	Arabidopsis thaliana	45-51
24801072-7	2015	Indeed, gene silencing of Pin1 in HAECs suppressed p66(Shc)-dependent ROS production, restored NO release and blunted NF-kB p65 nuclear translocation.	ros	70-73	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	26-30
24801072-7	2015	Indeed, gene silencing of Pin1 in HAECs suppressed p66(Shc)-dependent ROS production, restored NO release and blunted NF-kB p65 nuclear translocation.	ros	70-73	DNA polymerase delta 3, accessory subunit	Homo sapiens	51-54
27162477-9	2016	When ROS was cleared by N-acetylcysteine (NAC), OA-induced LC3-II convertsion and cell death were all reversed.	ros	5-8	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	59-62
26986073-0	2016	MiR-99a regulates ROS-mediated invasion and migration of lung adenocarcinoma cells by targeting NOX4.	ros	18-21	microRNA 99a	Homo sapiens	0-7
26986073-8	2016	By targeting NOX4-mediated ROS production, miR-99a regulated the invasion and migration of lung adenocarcinoma cells.	ros	27-30	microRNA 99a	Homo sapiens	43-50
26946493-5	2016	AP-1/c-Jun activation led to up-regulation of the Tgfbeta2 promoter, which in turn further potentiated intracellular ROS through the induction of NADPH oxidase (NOX).	ros	117-120	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
24223129-7	2013	Cathepsin B activity, K(+) efflux, Ca(2+) influx and ROS production were all required for the NLRP3 inflammasome activation by M.hy.	ros	53-56	NLR family, pyrin domain containing 3	Mus musculus	94-99
26946493-5	2016	AP-1/c-Jun activation led to up-regulation of the Tgfbeta2 promoter, which in turn further potentiated intracellular ROS through the induction of NADPH oxidase (NOX).	ros	117-120	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	5-10
26946493-5	2016	AP-1/c-Jun activation led to up-regulation of the Tgfbeta2 promoter, which in turn further potentiated intracellular ROS through the induction of NADPH oxidase (NOX).	ros	117-120	transforming growth factor beta 2	Homo sapiens	50-58
24601995-6	2015	However, in recent years it has been shown that spermatozoa naturally produce a variety of ROS/RNS, including superoxide anion radical (O2 ( -)), hydrogen peroxide and NO.	ros	91-94	FAM20C golgi associated secretory pathway kinase	Homo sapiens	95-98
24273738-10	2013	AA, BSO and CCl4 produced mitochondrial dysfunction, lowered cellular ATP levels and elevated mitochondrial production of ROS.	ros	122-125	C-C motif chemokine ligand 4	Homo sapiens	12-16
34547253-5	2022	We found that fibrillar aggregates of alpha-syn, but not HEWL, caused a significant increase in mitochondrial ROS, loss of membrane potential, and mitochondrial swelling, in a dose-dependent manner.	ros	110-113	synuclein alpha	Homo sapiens	38-47
27186289-4	2016	The phenotypes associated with GPx7 deficiency in mouse or human including ROS accumulations, highly elevated cancer incidences, auto-immune disorders, and obesity are also revealed in this paper.	ros	75-78	glutathione peroxidase 7	Mus musculus	31-35
26992231-4	2016	Our results further show that the elevation of SHC expression by NSUN2-mediated mRNA methylation increased the levels of ROS, activated p38MAPK, thereby accelerating oxidative stress- and high-glucose-induced senescence of human vascular endothelial cells (HUVEC).	ros	121-124	SHC adaptor protein 1	Homo sapiens	47-50
26850986-8	2016	Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels, and NAC could attenuate necroptotic cell death, indicating that the periplogenin-induced necroptotic cell death was mediated by oxidative stress.	ros	17-20	X-linked Kx blood group	Homo sapiens	77-80
26850986-8	2016	Furthermore, the ROS levels were elevated in the periplogenin-treated cells, NAC (an antioxidant) and Nec-1 could inhibit the ROS levels, and NAC could attenuate necroptotic cell death, indicating that the periplogenin-induced necroptotic cell death was mediated by oxidative stress.	ros	126-129	X-linked Kx blood group	Homo sapiens	77-80
34843865-3	2022	Topoisomerase IIalpha inhibition was associated with ROS-mediated activation of ATM-Chk2 kinase axis in HCT116 p53WT cells, but not in HCT116 p53-/- cells displaying early Chk1 activation.	ros	53-56	ATM serine/threonine kinase	Homo sapiens	80-83
23801081-1	2013	Isocitrate dehydrogenase 1 (IDH1) decarboxylates isocitrate to alpha-ketoglutarate (alpha-KG) leading to generation of NADPH, which is required to regenerate reduced glutathione (GSH), the major cellular ROS scavenger.	ros	204-207	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-26
23801081-1	2013	Isocitrate dehydrogenase 1 (IDH1) decarboxylates isocitrate to alpha-ketoglutarate (alpha-KG) leading to generation of NADPH, which is required to regenerate reduced glutathione (GSH), the major cellular ROS scavenger.	ros	204-207	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	28-32
26936198-0	2016	Chloride intracellular channel 1 regulates migration and invasion in gastric cancer by triggering the ROS-mediated p38 MAPK signaling pathway.	ros	102-105	chloride intracellular channel 1	Homo sapiens	0-32
23801081-6	2013	FACS analysis of cell death and ROS production also demonstrated an increased sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to BCNU, but not to temozolomide.	ros	32-35	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	93-97
23801081-6	2013	FACS analysis of cell death and ROS production also demonstrated an increased sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to BCNU, but not to temozolomide.	ros	32-35	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	125-129
34783868-9	2022	Furthermore, up-regulated miR-204 contributed to promotion of RTEC proliferation and suppression of ROS levels, RTEC apoptosis as well as formation of calcium oxalate crystal.	ros	100-103	microRNA 204	Homo sapiens	26-33
26764088-1	2016	Higher-functioning mitochondria that are more reduced and have less ROS are anchored in the yeast bud tip by the Dsl1-family protein Mmr1p.	ros	68-71	Dsl1p	Saccharomyces cerevisiae S288C	113-117
23801081-7	2013	The sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to ROS induction and cell death was further enhanced with the transaminase inhibitor aminooxyacetic acid and under glutamine free conditions, indicating that these cells were more addicted to glutaminolysis.	ros	68-71	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	19-23
26764088-1	2016	Higher-functioning mitochondria that are more reduced and have less ROS are anchored in the yeast bud tip by the Dsl1-family protein Mmr1p.	ros	68-71	Mmr1p	Saccharomyces cerevisiae S288C	133-138
23801081-7	2013	The sensitivity of IDH1-R132H-expressing cells and IDH1 KD cells to ROS induction and cell death was further enhanced with the transaminase inhibitor aminooxyacetic acid and under glutamine free conditions, indicating that these cells were more addicted to glutaminolysis.	ros	68-71	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	51-55
34896468-7	2022	The application of ROS scavenger NAC not only significantly inhibited the toxicity of Curcin C but also prevented the happen of apoptosis and autophagy to some extent.	ros	19-22	synuclein alpha	Homo sapiens	33-36
24025359-3	2013	Combination of these two agents resulted in increased autophagy that was dependent on expression of ceramide synthase 6, with HDACIs enhancing MDA-7/IL-24 toxicity by increasing generation of ROS and Ca (2+).	ros	192-195	interleukin 24	Homo sapiens	143-148
34755401-6	2022	The observed necro-apoptotic anticancer activity of Ir2 was due to the photo-triggered intracellular redox imbalance (by NAD(P)H oxidation and ROS generation) and change in the mitochondrial membrane potential.	ros	143-146	immune response 2	Mus musculus	52-55
34530165-0	2022	CLE14 functions as a "brake signal" suppressing age-dependent and stress-induced leaf senescence through promoting JUB1-mediated ROS scavenge in Arabidopsis.	ros	129-132	CLAVATA3/ESR-RELATED 14	Arabidopsis thaliana	0-5
34530165-4	2022	Here we report a small secreted peptide, CLAVATA3/ESR-RELATED (CLE) 14, which functions in suppressing leaf senescence through regulating ROS homeostasis in Arabidopsis.	ros	138-141	CLAVATA3/ESR-RELATED 14	Arabidopsis thaliana	41-70
34530165-9	2022	Further analysis showed that CLE14 gain-of-function led to reduced ROS levels in leaves, where higher expression of ROS scavenging genes were detected.	ros	67-70	CLAVATA3/ESR-RELATED 14	Arabidopsis thaliana	29-34
26868434-1	2016	p66Shc-dependent ROS production contributes to many pathologies including ischemia/reperfusion injury (IRI) during solid organ transplantation.	ros	17-20	src homology 2 domain-containing transforming protein C1	Mus musculus	0-6
26868434-9	2016	We further confirmed JNK1/2-dependent regulation of p66ShcS36 phosphorylation, ROS production and cell death using JNK1/2 deficient MEFs.	ros	79-82	mitogen-activated protein kinase 8	Mus musculus	21-27
26868434-10	2016	Finally, the low ROS phenotype of JNK1/2 knockout MEFs was reversed by the phosphomimetic p66ShcS36E mutant.	ros	17-20	mitogen-activated protein kinase 8	Mus musculus	34-40
34530165-9	2022	Further analysis showed that CLE14 gain-of-function led to reduced ROS levels in leaves, where higher expression of ROS scavenging genes were detected.	ros	116-119	CLAVATA3/ESR-RELATED 14	Arabidopsis thaliana	29-34
24084737-4	2013	Knockdown of Hsp60 in a mouse hypothalamic cell line mimicked the mitochondrial dysfunction observed in diabetic mice and resulted in increased ROS production and insulin resistance, a phenotype that was reversed with antioxidant treatment.	ros	144-147	heat shock protein 1 (chaperonin)	Mus musculus	13-18
34530165-11	2022	Notably, the function of CLE14 peptides was JUB1-dependent in delaying leaf senescence, reducing H2O2 level, and activating ROS scavenging genes.	ros	124-127	CLAVATA3/ESR-RELATED 14	Arabidopsis thaliana	25-30
34530165-12	2022	We propose that small peptide CLE14 serves as a novel "brake signal" in regulating age-dependent and stress-induced leaf senescence through JUB1-mediated ROS scavenging.	ros	154-157	CLAVATA3/ESR-RELATED 14	Arabidopsis thaliana	30-35
23962802-1	2013	The transcription factor ZAT12 is a member of stress-responsive C2H2 type zinc finger protein (ZFP) reported to control the expression of stress-activated genes mediated via ROS in plants.	ros	174-177	C2H2-type zinc finger protein	Solanum lycopersicum	64-93
34710950-5	2022	The nanoassemblies could be activated by the elevated ROS levels in tumor intracellular environment and readily release the incorporated therapeutic contents, afterwards DEM could directly conjugate to GSH to disrupt the glutathione peroxidase 4 (GPX4)-mediated antioxidant defense while siMCT4 could block the MCT4-mediated efflux of lactic acid and acidify the intracellular milieu, both of which could improve the ferrocene-catalyzed lipid peroxidation and induce pronounced ferroptotic damage.	ros	54-57	glutathione peroxidase 4	Homo sapiens	221-245
34710950-5	2022	The nanoassemblies could be activated by the elevated ROS levels in tumor intracellular environment and readily release the incorporated therapeutic contents, afterwards DEM could directly conjugate to GSH to disrupt the glutathione peroxidase 4 (GPX4)-mediated antioxidant defense while siMCT4 could block the MCT4-mediated efflux of lactic acid and acidify the intracellular milieu, both of which could improve the ferrocene-catalyzed lipid peroxidation and induce pronounced ferroptotic damage.	ros	54-57	glutathione peroxidase 4	Homo sapiens	247-251
34710950-5	2022	The nanoassemblies could be activated by the elevated ROS levels in tumor intracellular environment and readily release the incorporated therapeutic contents, afterwards DEM could directly conjugate to GSH to disrupt the glutathione peroxidase 4 (GPX4)-mediated antioxidant defense while siMCT4 could block the MCT4-mediated efflux of lactic acid and acidify the intracellular milieu, both of which could improve the ferrocene-catalyzed lipid peroxidation and induce pronounced ferroptotic damage.	ros	54-57	solute carrier family 16 member 3	Homo sapiens	311-315
34784560-8	2022	In addition, murine IL-32 gamma Tg neutrophils were able to kill L. infantum due to the increased production of ROS when compared with WT neutrophils.	ros	112-115	interleukin 32	Homo sapiens	20-31
26177712-2	2016	Tumor necrosis factor-alpha (TNFalpha) and radical oxygen species (ROS) up-regulate the expression of ICAM-1.	ros	67-70	intercellular adhesion molecule 1	Homo sapiens	102-108
26177712-5	2016	ROS production increases in cells treated with BSO or TNFalpha, and this has been related to an up-regulation of ICAM-1 expression and sICAM-1 release.	ros	0-3	intercellular adhesion molecule 1	Homo sapiens	113-119
26177712-7	2016	Moreover, also expression and activation of A disintegrin and metalloproteinase 17, a membrane-bound enzyme known as TNFalpha-converting enzyme (TACE), have been related to ROS levels.	ros	173-176	ADAM metallopeptidase domain 17	Homo sapiens	117-143
26177712-7	2016	Moreover, also expression and activation of A disintegrin and metalloproteinase 17, a membrane-bound enzyme known as TNFalpha-converting enzyme (TACE), have been related to ROS levels.	ros	173-176	ADAM metallopeptidase domain 17	Homo sapiens	145-149
26813308-4	2016	In vitro study in colorectal cancer cells demonstrated inhibition of SCD1 activity promoted apoptosis attributed to mitochondria dysfunctions, upregulation of reaction oxygen species (ROS), alteration of mitochondrial transmembrane potential and translocation of mitochondrial protein cytochrome C. While these effects were mediated by intracellular ceramide signals through induction of ceramide biosynthesis, rather than exclusive SFA accumulation.	ros	184-187	stearoyl-Coenzyme A desaturase 1	Mus musculus	69-73
24086569-10	2013	Inhibition of ROS-induced Smad3 activation by carvedilol resulted in downregulation of Col1a1, Col3a1, and alpha-SMA and upregulation of miR-29b derived from the miR-29b-2 precursor.	ros	14-17	collagen type III alpha 1 chain	Rattus norvegicus	95-101
26721440-5	2016	Further analysis with iTraq identified CYP1B1, a component of the cytochrome p450 system, as a potential molecule mediating ROS generation in pNO40 deficient MSCs.	ros	124-127	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	39-45
23800743-6	2013	Internalized Tf-SeNPs triggers intracellular ROS overproduction, thus activates p53 and MAPKs pathways to promote cell apoptosis.	ros	45-48	transformation related protein 53, pseudogene	Mus musculus	80-83
26625314-5	2016	The corrective effects of PPARgamma ligand on lal-/- MDSCs functions were mediated by regulating the mammalian target of rapamycin (mTOR) pathway, and subsequently blocking MDSCs ROS overproduction.	ros	179-182	lysosomal acid lipase A	Mus musculus	46-49
28959532-7	2016	We hypothesize that Mel may be scavenging reactive species of oxygen (ROS) that could be damaging lipids, PEPCK, G6Pase and ferrochelatase (FQ).	ros	70-73	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	106-111
34784560-10	2022	In parallel, treatment of human neutrophils with recombinant IL-32 gamma increased phagocytosis and ROS-dependent killing of L. infantum, similarly to murine IL-32 gamma Tg neutrophils.	ros	100-103	interleukin 32	Homo sapiens	61-72
34906793-7	2022	Our study revealed that m-beta-CoV upregulated Park7, RelA, Nrf2, and Hmox1 transcripts involved in ROS production and antioxidant pathways, describing the possible nexus between oxidative pathways, MMPs, and TIMP in m-beta-CoV-induced neuroinflammation.	ros	100-103	Parkinsonism associated deglycase	Homo sapiens	47-52
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	ros	214-217	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	66-69
34906793-7	2022	Our study revealed that m-beta-CoV upregulated Park7, RelA, Nrf2, and Hmox1 transcripts involved in ROS production and antioxidant pathways, describing the possible nexus between oxidative pathways, MMPs, and TIMP in m-beta-CoV-induced neuroinflammation.	ros	100-103	heme oxygenase 1	Homo sapiens	70-75
26515689-8	2016	Moreover, Abeta also reduced sirtuin 1 (Sirt1) and its downstream signaling, resulting in increased intracellular ROS accumulation and mitochondrial dysfunction.	ros	114-117	sirtuin 1	Homo sapiens	29-38
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	ros	214-217	BCL2 associated X, apoptosis regulator	Rattus norvegicus	162-165
26515689-8	2016	Moreover, Abeta also reduced sirtuin 1 (Sirt1) and its downstream signaling, resulting in increased intracellular ROS accumulation and mitochondrial dysfunction.	ros	114-117	sirtuin 1	Homo sapiens	40-45
34968486-9	2022	We also found MIT upregulated PD-L1 expression in cancer cells possibly via inhibiting PD-L1 ubiquitination, increasing ROS and IFN-gamma.	ros	120-123	CD274 molecule	Homo sapiens	30-35
26884717-4	2016	Here, glucose oxidase (GOX) was used to induce ROS generation in HepG2 cells and liver tissues of mice.	ros	47-50	hydroxyacid oxidase 1	Homo sapiens	6-21
23729662-7	2013	Analyses of the downstream pathway suggest that protein kinase A (PKA)-dependent phosphorylation and the mitochondrial translocation of the pro-apoptotic protein Bax is a key link between sAC and oxysterol-induced ROS formation and apoptosis.	ros	214-217	adenylate cyclase 10	Rattus norvegicus	188-191
26884717-4	2016	Here, glucose oxidase (GOX) was used to induce ROS generation in HepG2 cells and liver tissues of mice.	ros	47-50	hydroxyacid oxidase 1	Homo sapiens	23-26
23729662-9	2013	sAC expression in the cytosol, but not in mitochondria, significantly promoted apoptosis and ROS formation during oxysterol treatment.	ros	93-96	adenylate cyclase 10	Rattus norvegicus	0-3
23729662-10	2013	CONCLUSION: These results suggest that the sAC/PKA axis plays a key role in the oxysterol-induced apoptosis of VSMC by controlling mitochondrial Bax translocation and ROS formation and that cytosolic sAC, rather than the mitochondrial pool, is involved in the apoptotic mechanism.	ros	167-170	adenylate cyclase 10	Rattus norvegicus	43-46
34563514-11	2021	Overexpression of miR-125b mimics or knockdown of STAT3 or HMGB1 alleviated LPS-induced hindrance of autophagic flux and ROS production.	ros	121-124	signal transducer and activator of transcription 3	Rattus norvegicus	50-55
34563514-14	2021	Hyperactivation of STAT3/HMGB1 caused by reduced miR-125b contributes to ROS generation and the hindrance of autophagic flux during septic cardiomyopathy, leading to myocardial dysfunction.	ros	73-76	signal transducer and activator of transcription 3	Rattus norvegicus	19-24
26595812-2	2016	In the present study, we employed mouse models with excessive vascular production of ROS (tg(sm/p22phox) mice, which overexpress the NADPH oxidase subunit p22(phox) in smooth muscle, and mice with vascular-specific deletion of extracellular SOD) and have shown that these animals develop vascular collagen deposition, aortic stiffening, renal dysfunction, and hypertension with age.	ros	85-88	cytochrome b-245, alpha polypeptide	Mus musculus	96-103
23729662-10	2013	CONCLUSION: These results suggest that the sAC/PKA axis plays a key role in the oxysterol-induced apoptosis of VSMC by controlling mitochondrial Bax translocation and ROS formation and that cytosolic sAC, rather than the mitochondrial pool, is involved in the apoptotic mechanism.	ros	167-170	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	47-50
23896225-5	2013	ERK5 siRNA induced higher apoptosis rate; intracellular Ca(2+) overload; ROS activity; DeltaPsim damage in hypothermia stimulated CMs, when compared with hypothermal stimulation solely treated group, while Bim siRNA effected oppositely and canceled pro-apoptotic effect of ERK5 siRNA.	ros	73-76	mitogen-activated protein kinase 7	Homo sapiens	0-4
26734017-10	2015	This effect on pollen germination can only partially be attributed to COX deficiency and may indicate a possible auxiliary role of COX11 in ROS metabolism.	ros	140-143	Cox11p	Saccharomyces cerevisiae S288C	131-136
26514923-9	2015	In addition, N-acetyl-l-cystein (NAC), diphenyleneiodonium chloride (DPI) and apocynin (APO) inhibited the Cd-induced activation of EGFR, Akt, Erk1/2, JNK1/2, and p38 MAPK, indicating that ROS production by NADPH oxidase is the furthest upstream signal in MMP-9 expression.	ros	189-192	X-linked Kx blood group	Homo sapiens	13-31
26514923-9	2015	In addition, N-acetyl-l-cystein (NAC), diphenyleneiodonium chloride (DPI) and apocynin (APO) inhibited the Cd-induced activation of EGFR, Akt, Erk1/2, JNK1/2, and p38 MAPK, indicating that ROS production by NADPH oxidase is the furthest upstream signal in MMP-9 expression.	ros	189-192	X-linked Kx blood group	Homo sapiens	33-36
26514923-11	2015	These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR-&gt;Erk1/2, JNK1/2-&gt;AP-1 and EGFR-&gt;Akt-&gt;NF-kappaB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells.	ros	64-67	matrix metallopeptidase 9	Homo sapiens	43-48
26514923-11	2015	These results demonstrated that Cd induces MMP-9 expression via ROS-dependent EGFR-&gt;Erk1/2, JNK1/2-&gt;AP-1 and EGFR-&gt;Akt-&gt;NF-kappaB signaling pathways and, in turn, stimulates invasiveness in human endothelial cells.	ros	64-67	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-110
34943060-8	2021	The cytoprotective effect of l-Arg was restricted by the SIRT1 inhibitor EX527, which led to an increase in ROS level, apoptosis rate, and decreased cell MMP.	ros	108-111	sirtuin 1	Mus musculus	57-62
23896225-6	2013	In conclusion, ERK5 knock down releases inhibition to Bim expression, induces aggravated apoptosis in CMs under hypothermal stimulation, which related to higher intracellular Ca(2+) overload, ROS activity, and more severe DeltaPsim damage.	ros	192-195	mitogen-activated protein kinase 7	Homo sapiens	15-19
34864826-0	2021	Targeting ERK induced cell death and p53/ROS-dependent protective autophagy in colorectal cancer.	ros	41-44	transformation related protein 53, pseudogene	Mus musculus	37-40
34864826-9	2021	Therefore, we confirmed that CC90003 could induce autophagy by activating ROS/p53.	ros	74-77	transformation related protein 53, pseudogene	Mus musculus	78-81
26524401-6	2015	The expression of TRIM4 induces mitochondrial aggregation and increased level of mitochondrial ROS in the presence of H2O2.	ros	95-98	tripartite motif containing 4	Homo sapiens	18-23
23860378-8	2013	Similar results were obtained with two divergent oncogenes (RAS and NFkappaB), indicating that ROS production and inflammation metabolically converge on the tumor stroma, driving glycolysis and upregulation of MCT4.	ros	95-98	solute carrier family 16 member 3	Homo sapiens	210-214
26310940-2	2015	We have previously shown that adoptive transfer of CD4(+) T cells from the reduced uterine perfusion pressure (RUPP) rat model of PE increases blood pressure, oxidative stress (ROS), and inflammation in normal pregnant recipient rats.	ros	177-180	Cd4 molecule	Rattus norvegicus	51-54
26310940-8	2015	Inhibition of CD40L binding reduced placental ET-1 to 2.3-fold above NP rats and normalized placental ROS from 318.6 +- 89 in NP+RUPP CD4(+) T cells (P &lt; 0.05) to 118.7 +- 24 in NP+RUPP CD4(+) T+anti-CD40L (P &lt; 0.05).	ros	102-105	Cd4 molecule	Rattus norvegicus	14-17
25199686-7	2015	Moreover, endosulfan increased production of the ROS and the ROS-producing NAPDH-oxidase (NOX) family oxidases, NOX2, and NOX3.	ros	61-64	NADPH oxidase 3	Mus musculus	122-126
34864826-11	2021	In a word, our results demonstrated that targeting ERK leads to cell death and p53/ROS-dependent protective autophagy simultaneously in colorectal cancer, which offers new potential targets for clinical therapy.	ros	83-86	transformation related protein 53, pseudogene	Mus musculus	79-82
34506261-9	2021	Our results suggest that argon preconditioning inhibited the PDCD4/PTEN pathway via miR-21, thereby inhibiting ROS oxidative stress and preventing MI/R injury.	ros	111-114	phosphatase and tensin homolog	Homo sapiens	67-71
34506261-9	2021	Our results suggest that argon preconditioning inhibited the PDCD4/PTEN pathway via miR-21, thereby inhibiting ROS oxidative stress and preventing MI/R injury.	ros	111-114	microRNA 21	Homo sapiens	84-90
23436141-4	2013	Activation of the TLR4 pathways may cause chronic inflammation and increased production of reactive oxygen and nitrogen species (ROS/RNS) and oxidative and nitrosative stress and therefore TLR-related diseases.	ros	129-132	toll like receptor 4	Homo sapiens	18-22
34586588-4	2021	In these cells, cytotoxicity (MTT assay) and activation of ER- and mitochondria-dependent cell death pathways (mRNA expression of GRP78, ATF6, IRE1, PERK; ROS levels by MitoSOX and DCFDA-AM; JC-1 staining) induced by the thiosemicarbazones FA4, MLP44, PS3 and ACthio-1, were evaluated.	ros	155-158	taste 2 receptor member 6 pseudogene	Homo sapiens	252-255
34688609-0	2021	CPT2 downregulation triggers stemness and oxaliplatin resistance in colorectal cancer via activating the ROS/Wnt/beta-catenin-induced glycolytic metabolism.	ros	105-108	catenin beta 1	Homo sapiens	113-125
34688609-9	2021	Mechanistically, CPT2 functioned via suppressing the activation of Wnt/beta-catenin pathway through repressing ROS production.	ros	111-114	catenin beta 1	Homo sapiens	71-83
26251197-6	2015	The protective effect of Ang1-7 was associated with the inhibition of ROS-associated mitochondrial dysfunction as well as the induction of Akt phosphorylation.	ros	70-73	angiogenin	Rattus norvegicus	25-29
26224570-5	2015	Hence, we show a direct involvement of the TWEAK-Fn14 axis in oxidative stress, as genetic silencing of Fn14 or Nox2 abrogates the TWEAK-induced ROS production.	ros	145-148	TNF superfamily member 12	Homo sapiens	43-48
34688609-10	2021	In conclusion, our results demonstrated that CPT2 was decreased in CRC, and CPT2 downregulation could trigger stemness and oxaliplatin resistance in CRC via activating the ROS/Wnt/beta-catenin-induced glycolytic metabolism.	ros	172-175	catenin beta 1	Homo sapiens	180-192
34836795-6	2021	Subsequent studies carried out with 1-39 and 1A-38 showed that both compounds could reduce the production of ROS in the cells, probably through down-regulating NOX2 and its downstream targets, including TXNIP (thioredoxin-interacting protein) and NLRP3 (NOD-like receptor protein 3).	ros	109-112	NLR family, pyrin domain containing 3	Mus musculus	247-252
26224570-5	2015	Hence, we show a direct involvement of the TWEAK-Fn14 axis in oxidative stress, as genetic silencing of Fn14 or Nox2 abrogates the TWEAK-induced ROS production.	ros	145-148	cytochrome b-245 beta chain	Homo sapiens	112-116
26224570-5	2015	Hence, we show a direct involvement of the TWEAK-Fn14 axis in oxidative stress, as genetic silencing of Fn14 or Nox2 abrogates the TWEAK-induced ROS production.	ros	145-148	TNF superfamily member 12	Homo sapiens	131-136
26224570-8	2015	CONCLUSIONS: Our results suggest that TWEAK regulates vascular damage by stimulating ROS production in an Nox2-dependent manner.	ros	85-88	TNF superfamily member 12	Homo sapiens	38-43
23632460-8	2013	The compound was particularly effective in inhibiting thioredoxin reductase, that is likely responsible for the increased ROS production, and subsequent apoptosis induction via the mitochondrial pathway.	ros	122-125	peroxiredoxin 5	Homo sapiens	54-75
26224570-8	2015	CONCLUSIONS: Our results suggest that TWEAK regulates vascular damage by stimulating ROS production in an Nox2-dependent manner.	ros	85-88	cytochrome b-245 beta chain	Homo sapiens	106-110
26070526-8	2015	Our data indicated that propofol down-regulated PP2A expression, leading to reduced dephosphorylation of p66(Shc)-Ser(36) and eNOS-Ser(1177), which is associated with ROS accumulation and NO reduction, resulting in inhibition of endothelial adhesion molecule expression and mononuclear-endothelial interaction.	ros	167-170	SHC adaptor protein 1	Homo sapiens	109-112
34836795-6	2021	Subsequent studies carried out with 1-39 and 1A-38 showed that both compounds could reduce the production of ROS in the cells, probably through down-regulating NOX2 and its downstream targets, including TXNIP (thioredoxin-interacting protein) and NLRP3 (NOD-like receptor protein 3).	ros	109-112	NLR family, pyrin domain containing 3	Mus musculus	254-281
23671003-1	2013	O2.- scavenger: The rate constant for the rapid reaction of the ROS superoxide with the reduced vitamin B12 radical complex cob(II)alamin was directly determined to be 3.8x10(8) M-1 s-1.	ros	64-67	metabolism of cobalamin associated B	Homo sapiens	124-127
33719938-7	2021	In addition, we confirmed that mitochondrial Prx5 provides more effective neuroprotection than cytosolic Prx5.Discussion: Overall, our study reveals the mechanisms of cytosolic and mitochondrial ROS in glutamate toxicity.	ros	195-198	peroxiredoxin 5	Homo sapiens	45-49
33719938-7	2021	In addition, we confirmed that mitochondrial Prx5 provides more effective neuroprotection than cytosolic Prx5.Discussion: Overall, our study reveals the mechanisms of cytosolic and mitochondrial ROS in glutamate toxicity.	ros	195-198	peroxiredoxin 5	Homo sapiens	105-109
34666282-7	2021	Flow cytometry and immunnofluorescence showed that ATF3 deficiency inhibited H2O2-induced ROS production and the expression of 8 OHdG and 4-HNE.	ros	90-93	activating transcription factor 3	Homo sapiens	51-55
25597481-3	2015	The presence of GJIC composed of Connexin 32 increased the PDT phototoxicity in transfected HeLa cells and in the xenograft tumors, and the enhanced phototoxicity of Photofrin-mediated PDT by GJIC was related with ROS and calcium pathways.	ros	214-217	gap junction protein beta 1	Homo sapiens	33-44
26196303-5	2015	AMPK activators salicylate and AICAR prevented ROS-induced mitochondrial fission by enhancing dynamin-related protein 1 (Drp1) phosphorylation (Ser 637) and thereby attenuated IRE-1alpha and PERK phosphorylation, but their actions were blocked by knockdown of AMPK.	ros	47-50	dynamin 1-like	Rattus norvegicus	94-119
26196303-5	2015	AMPK activators salicylate and AICAR prevented ROS-induced mitochondrial fission by enhancing dynamin-related protein 1 (Drp1) phosphorylation (Ser 637) and thereby attenuated IRE-1alpha and PERK phosphorylation, but their actions were blocked by knockdown of AMPK.	ros	47-50	dynamin 1-like	Rattus norvegicus	121-125
23427251-5	2013	The Gabarap deficiency led to inefficient clearance of damaged mitochondria in LPS plus ATP-treated macrophages, resulting in more mitochondrial ROS and the release of mitochondrial DNA into cytosol.	ros	145-148	gamma-aminobutyric acid receptor associated protein	Mus musculus	4-11
26054569-4	2015	Ilexgenin A enhanced LKB1-dependent AMPK activity and improved ER stress by suppression of ROS-associated TXNIP induction.	ros	91-94	thioredoxin interacting protein	Rattus norvegicus	106-111
34843984-4	2022	QAuNP + NIR caused DNA damage and induce apoptosis in SCC-9-CSCs by deregulating mitochondrial membrane potential (DeltaPsim) and activation of ROS.	ros	144-147	NOC2 like nucleolar associated transcriptional repressor	Mus musculus	8-11
34363387-6	2021	In MA-10 cells in which Sirt1 or Nrf2 were suppressed by nicotinamide (NAM) or ML385, respectively, or in which siRNAs were used for knockdown of Sirt1 or Nrf2, increased ROS levels and decreased progesterone production occurred.	ros	171-174	sirtuin 1	Mus musculus	24-29
34363387-6	2021	In MA-10 cells in which Sirt1 or Nrf2 were suppressed by nicotinamide (NAM) or ML385, respectively, or in which siRNAs were used for knockdown of Sirt1 or Nrf2, increased ROS levels and decreased progesterone production occurred.	ros	171-174	sirtuin 1	Mus musculus	146-151
34868022-0	2021	Epithelial Aryl Hydrocarbon Receptor Protects From Mucus Production by Inhibiting ROS-Triggered NLRP3 Inflammasome in Asthma.	ros	82-85	NLR family, pyrin domain containing 3	Mus musculus	96-101
26302043-11	2015	Moreover, GLIPR1 silencing resulted in increased ROS levels both in untreated and SB225002-treated cells.	ros	49-52	GLI pathogenesis related 1	Homo sapiens	10-16
23271700-7	2013	Residues Tyr231 and Val232 also seemed to be important for p47phox function, as p47phox_Y231G and p47phox_V232G resulted in a &gt;50% decrease in ROS production by the NOX2 complex.	ros	146-149	neutrophil cytosolic factor 1	Mus musculus	59-66
26062875-7	2015	We conclude that the p67(phox) subunit of NADPH oxidase 2 plays an important role in the excess production of ROS from mitochondria in the renal medulla of the SS rat.	ros	110-113	cytochrome b-245 beta chain	Rattus norvegicus	42-57
23271700-7	2013	Residues Tyr231 and Val232 also seemed to be important for p47phox function, as p47phox_Y231G and p47phox_V232G resulted in a &gt;50% decrease in ROS production by the NOX2 complex.	ros	146-149	neutrophil cytosolic factor 1	Mus musculus	80-87
34651186-5	2021	YAP1-dependent mitochondrial fragmentation and ROS generation was accompanied by decreased TERT levels and increased mitochondrial TERT localization in IDH1 R132H cells.	ros	47-50	telomerase reverse transcriptase	Homo sapiens	131-135
23271700-7	2013	Residues Tyr231 and Val232 also seemed to be important for p47phox function, as p47phox_Y231G and p47phox_V232G resulted in a &gt;50% decrease in ROS production by the NOX2 complex.	ros	146-149	neutrophil cytosolic factor 1	Mus musculus	80-87
23271700-9	2013	In conclusion, the p47phox protein variant expressed in Ncf1(m1J) mice is completely defective in activating the NOX2 complex to produce ROS, and the effect is dependent on SH3 region amino acids at positions 231-233, which are vital for the proper assembly of the NOX2 complex.	ros	137-140	neutrophil cytosolic factor 1	Mus musculus	19-26
34481142-11	2021	Silencing of TNFAIP3 or RIP3T led to elevated proliferation and inhibited apoptosis in AR42J cells, accompanied by decreased inflammatory cytokine levels and ROS production.	ros	158-161	TNF alpha induced protein 3	Rattus norvegicus	13-20
34481142-12	2021	The protective role of inhibited TNFAIP3 in AP was confirmed evidenced by reduced levels of AMY, LIPA, and ROS in vivo.	ros	107-110	TNF alpha induced protein 3	Rattus norvegicus	33-40
26028291-8	2015	N-acetyl cysteine or melatonin treatments, significantly dampened the Bmal1 promoter activity suggesting that sustained scavenging of ROS impairs clock synchronization.	ros	134-137	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	70-75
23271700-9	2013	In conclusion, the p47phox protein variant expressed in Ncf1(m1J) mice is completely defective in activating the NOX2 complex to produce ROS, and the effect is dependent on SH3 region amino acids at positions 231-233, which are vital for the proper assembly of the NOX2 complex.	ros	137-140	neutrophil cytosolic factor 1	Mus musculus	56-64
23758151-0	2013	Induction of miR-21-PDCD4 signaling by tungsten carbide-cobalt nanoparticles in JB6 cells involves ROS-mediated MAPK pathways.	ros	99-102	microRNA 21	Homo sapiens	13-19
25982144-14	2015	In addition, ALA-SDT significantly increased intracellular ROS levels in vitro, which were almost inhibited by the ROS scavenger NAC.	ros	59-62	NLR family, pyrin domain containing 1A	Mus musculus	129-132
25982144-14	2015	In addition, ALA-SDT significantly increased intracellular ROS levels in vitro, which were almost inhibited by the ROS scavenger NAC.	ros	115-118	NLR family, pyrin domain containing 1A	Mus musculus	129-132
23950593-10	2013	CONCLUSIONS: These results suggested that BDMC-induced ROS accumulation may contribute to its inhibitory effect on MCF-7 cell viability through regulation of p53/p21 and p16/Rb pathways.	ros	55-58	H3 histone pseudogene 16	Homo sapiens	162-165
26059056-0	2015	Curcumin inhibits the invasion of lung cancer cells by modulating the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway.	ros	85-88	cytochrome b-245 beta chain	Homo sapiens	79-84
26314448-7	2015	CONCLUSION: PDI participates in the induced GPIbalpha ectodomein shedding, and the effect of PDI in this process maybe depend on the change of ROS level inside platelets.	ros	143-146	glycoprotein Ib platelet subunit alpha	Homo sapiens	44-53
34173812-8	2021	Fisetin could also ameliorate and reduce oxLDL-induced upregulation of SREBP-1 and thereby expression of its downstream liposynthesis genes HMGCR and FAS via inhibiting ROS-induced NLRP3 activation.	ros	169-172	sterol regulatory element binding transcription factor 1	Homo sapiens	71-78
23019230-8	2012	Experiments with cultured podocytes revealed previously unrecognized cross talk between p66 and the redox-sensitive transcription factor p53 that controls hyperglycemia-induced ROS metabolism, transcription of p53 target genes (angiotensinogen, angiotensin II type-1 receptor, and bax), angiotensin II generation, and apoptosis.	ros	177-180	transformation related protein 53, pseudogene	Mus musculus	137-140
34173812-8	2021	Fisetin could also ameliorate and reduce oxLDL-induced upregulation of SREBP-1 and thereby expression of its downstream liposynthesis genes HMGCR and FAS via inhibiting ROS-induced NLRP3 activation.	ros	169-172	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	140-145
34508760-9	2021	More importantly, HMOX1 knockdown attenuated Fe2+ overload, reduced iron content and ROS, and alleviated lipid peroxidation, which led to a reduction in ferroptosis in diabetic human endothelial cells.	ros	85-88	heme oxygenase 1	Homo sapiens	18-23
34311033-7	2021	Furthermore, we confirmed the role of TRPC3 and the ROCE-AKT/GSK3beta-CNB2/NFATc2 signaling cascade in regulating cell cycle checkpoint, apoptosis cascade, and intracellular ROS production in GC.	ros	174-177	nuclear factor of activated T cells 2	Homo sapiens	75-81
26226833-10	2015	These results demonstrated that fatty acid oxidation resulted in ROS generation, activating P53/Bax-mediated mitochondrial apoptosis, leading to reduction of osteogenic differentiation and bone loss in T2DM.	ros	65-68	BCL2-associated X protein	Mus musculus	96-99
25857619-7	2015	On the other hand, electrical stimuli induced higher ROS production in mdx than wt myotubes, which were blocked by NOX2 inhibitors.	ros	53-56	cytochrome b-245 beta chain	Homo sapiens	115-119
25712449-8	2015	Although PDGF-B and -D mediate their functions mainly by PDGFRbeta and ROS generation, there are many differences between them in terms of regulating ASCs.	ros	71-74	platelet derived growth factor subunit B	Homo sapiens	9-15
22773120-5	2012	Importantly, miR-338 modulation of local COXIV and ATP5G1 expression has a marked effect on axonal ROS levels, as well as axonal growth.	ros	99-102	microRNA 338	Homo sapiens	13-20
22930452-8	2012	These data suggest that TCR-induced ROS generation from NOX2 activation can regulate the adaptive immune response in a T-cell-inherent fashion, and propose a possible role for redox signaling in T helper differentiation.	ros	36-39	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	24-27
25824615-4	2015	As PPAR-gamma activation exerts anti-inflammatory effects and reduces ROS production, IRB may further reduce inflammatory chemokine expression and suppress apoptotic cell death.	ros	70-73	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	3-13
25896763-7	2015	Furthermore, inhibition of ROS activity by N-acetyl-l-cysteine (NAC) eliminated the OGD-induced increase in TRPC6 expression and Ca(2+) influx.	ros	27-30	X-linked Kx blood group	Homo sapiens	64-67
26078725-10	2015	ROS scavenger N-acetyl-L-cysteine (NAC) blocked the autophagy process induced by 5cGy alpha particle, the upregulation of Nrf2 and HO-1, as well as the induced radio-resistance.	ros	0-3	X-linked Kx blood group	Homo sapiens	35-38
25724548-0	2015	Effects of exposure to benzo[a]pyrene on metastasis of breast cancer are mediated through ROS-ERK-MMP9 axis signaling.	ros	90-93	matrix metallopeptidase 9	Homo sapiens	98-102
25724548-7	2015	Our results suggest that benzo[a]pyrene-induced mammary gland cancer metastasis is an important and intricate process facilitated by cumulative benzo[a]pyrene exposure leading to activation of the ROS-ERK-MMP9 signaling pathway.	ros	197-200	matrix metallopeptidase 9	Homo sapiens	205-209
25749575-12	2015	We demonstrate that GB decreases ROS generation through reducing NOX2 expression and enhancing activity through Akt-Nrf2-HO-1 pathway, resulting in inhibition of mitochondrial apoptosis and final reduction of cisplatin-induced ototoxicity in vitro and in vivo.	ros	33-36	heme oxygenase 1	Rattus norvegicus	121-125
25539708-6	2015	Moreover, we found that pretreatment with NAC markedly inhibited the expression levels of c-FLIP, Mcl-1, and Bcl-2 downregulated by the combinatory treatment, suggesting that the regulating effect of EGCG on these above apoptosis-relevant molecules was partially mediated by generation of ROS.	ros	289-292	X-linked Kx blood group	Homo sapiens	42-45
25767116-4	2015	Recombinant ROS-GCs synthesized cGMP from GTP at faster rates in the presence of bicarbonate with an ED50 of 27 mM for ROS-GC1 and 39 mM for ROS-GC2.	ros	12-15	guanylate cyclase 2F, retinal	Homo sapiens	141-148
25832424-0	2015	C-reactive protein stimulates RAGE expression in human coronary artery endothelial cells in vitro via ROS generation and ERK/NF-kappaB activation.	ros	102-105	advanced glycosylation end-product specific receptor	Homo sapiens	30-34
25832424-6	2015	RESULTS: CRP stimulated the expression of RAGE in the cells, accompanied by markedly increased ROS generation, phosphorylation of ERK1/2 and NF-kappaB p65, as well as translocation of NF-kappaB p65 to the nuclei.	ros	95-98	advanced glycosylation end-product specific receptor	Homo sapiens	42-46
25832424-8	2015	Pretreatment of the cells with the ROS scavenger N-acetyl-L-cysteine, ERK inhibitor PD98059 or NF-kappaB inhibitor PDTC blocked CRP-stimulated RAGE expression, but pretreatment with the NADPH oxidase inhibitor DPI, JNK inhibitor SP600125 or p38 MAPK inhibitor SB203580 did not significantly alter CRP-stimulated RAGE expression.	ros	35-38	advanced glycosylation end-product specific receptor	Homo sapiens	143-147
25832424-8	2015	Pretreatment of the cells with the ROS scavenger N-acetyl-L-cysteine, ERK inhibitor PD98059 or NF-kappaB inhibitor PDTC blocked CRP-stimulated RAGE expression, but pretreatment with the NADPH oxidase inhibitor DPI, JNK inhibitor SP600125 or p38 MAPK inhibitor SB203580 did not significantly alter CRP-stimulated RAGE expression.	ros	35-38	advanced glycosylation end-product specific receptor	Homo sapiens	312-316
25832424-9	2015	CONCLUSION: CRP stimulates RAGE expression in HCAECs in vitro via ROS generation and activation of the ERK/NF-kappaB signaling pathway.	ros	66-69	advanced glycosylation end-product specific receptor	Homo sapiens	27-31
25484314-8	2015	Analysis of the mRNA expression levels of the two NOX isoforms implicated in brain pathology showed, that NOX2 is dramatically upregulated under conditions of Nrf2 deficiency, whereas NOX4 is upregulated when Nrf2 is constitutively activated (Keap1-KD) to a degree which paralleled the increases in ROS production.	ros	299-302	cytochrome b-245 beta chain	Homo sapiens	106-110
25774669-8	2015	Furthermore, ROS inhibitor, NAC reduced HDAC6 siRNA-induced ROS production, and blocked HDAC6 siRNA-induced loss of MMP and apoptosis.	ros	13-16	X-linked Kx blood group	Homo sapiens	28-31
25774669-8	2015	Furthermore, ROS inhibitor, NAC reduced HDAC6 siRNA-induced ROS production, and blocked HDAC6 siRNA-induced loss of MMP and apoptosis.	ros	60-63	X-linked Kx blood group	Homo sapiens	28-31
25140833-5	2015	In this report, we show that the E3 ubiquitin ligase, c-CBL, is overexpressed in CTCL and that its knockdown overcomes defective TCR signaling, resulting in phosphorylation of PLC-g1, calcium influx, ROS generation, upregulation of FASL, and extrinsic pathway apoptosis in CTCL cells expressing adequate FAS.	ros	200-203	Cbl proto-oncogene like 2	Homo sapiens	33-52
25555803-9	2015	In contrast, RNAi-mediated suppression of either Opa1 or mitofusin/MARF induced cardiac dysfunction associated with mitochondrial depolarization and ROS production.	ros	149-152	Optic atrophy 1	Drosophila melanogaster	49-53
25555803-9	2015	In contrast, RNAi-mediated suppression of either Opa1 or mitofusin/MARF induced cardiac dysfunction associated with mitochondrial depolarization and ROS production.	ros	149-152	Mitochondrial assembly regulatory factor	Drosophila melanogaster	57-66
25555803-9	2015	In contrast, RNAi-mediated suppression of either Opa1 or mitofusin/MARF induced cardiac dysfunction associated with mitochondrial depolarization and ROS production.	ros	149-152	Mitochondrial assembly regulatory factor	Drosophila melanogaster	67-71
25555803-10	2015	Inhibiting ROS by overexpressing superoxide dismutase (SOD) or suppressing ROMO1 prevented mitochondrial and heart tube dysfunction provoked by Opa1 RNAi, but not by mitofusin/MARF RNAi.	ros	11-14	uncharacterized protein	Drosophila melanogaster	75-80
25555803-10	2015	Inhibiting ROS by overexpressing superoxide dismutase (SOD) or suppressing ROMO1 prevented mitochondrial and heart tube dysfunction provoked by Opa1 RNAi, but not by mitofusin/MARF RNAi.	ros	11-14	Optic atrophy 1	Drosophila melanogaster	144-148
25683712-3	2015	HIGD1A is induced in these HIF-deficient extreme environments and interacts with the mitochondrial electron transport chain to repress oxygen consumption, enhance AMPK activity, and lower cellular ROS levels.	ros	197-200	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	0-6
26495010-8	2015	Dichlorofluorescein diacetate (DCFH-DA) staining result showed that luteolin reduced Ang II-stimulated ROS production in VSMCs.	ros	103-106	angiogenin	Rattus norvegicus	85-88
25463278-7	2015	Furthermore, Sesn2 prevented LPS-elicited cell death and ROS production via inhibition of NADPH oxidase.	ros	57-60	sestrin 2	Mus musculus	13-18
26634216-7	2015	Hydroxy-3-methoxyaceto-phenone (HMAP), diphenyleneiodonium (DPI), and siRNA Nox2 reduced the ROS and IL-8 release in neutrophils treated with fMLP.	ros	93-96	cytochrome b-245 beta chain	Homo sapiens	76-80
25193023-0	2015	Romo1 is associated with ROS production and cellular growth in human gliomas.	ros	25-28	reactive oxygen species modulator 1	Homo sapiens	0-5
25193023-5	2015	Romo1 expression was associated with ROS production and its knockdown led to a marked reduction of in vitro cellular growth and anchorage-independent growth of GBM.	ros	37-40	reactive oxygen species modulator 1	Homo sapiens	0-5
25234195-7	2015	Meaningfully, pretreatment of a type of ROS scavenger formulations named N-(mercaptopropionyl)-glycine (N-MPG) could inhibit podocyte apoptosis induced by Ang II.	ros	40-43	N-methylpurine DNA glycosylase	Homo sapiens	106-109
25864557-8	2015	DISCUSSION AND CONCLUSION: The protective function of TSA on myocardial ischemia reperfusion injury may be possibly exerted by inhibiting the increase of ROS caused by the reperfusion to attenuate the expression of HMGB1 and inhibit inflammation.	ros	154-157	high mobility group box 1	Rattus norvegicus	215-220
26366812-10	2015	Meaningfully, treatment of a type of ROS scavenger formulation named N-(mercaptopropionyl)-glycine (N-MPG) could inhibit MCs death induced by melamine.	ros	37-40	N-methylpurine DNA glycosylase	Homo sapiens	102-105
25201588-4	2014	We found that NNMT significantly accelerates cell proliferation, enhances colony formation in vitro and tumorigenicity in mice; it also inhibits apoptosis, promotes cell cycle progression, increases ATP and 1-methylnicotinamide level and decreases ROS level.	ros	248-251	nicotinamide N-methyltransferase	Mus musculus	14-18
25514461-5	2014	Correlation analysis revealed positive relationships between HSP70 levels and zymosan-stimulated ROS production in the elder group.	ros	97-100	heat shock protein family A (Hsp70) member 4	Homo sapiens	61-66
25514461-6	2014	This was consistent with a promoting role for HSP70 in ROS-associated neutrophils response to pathogens.	ros	55-58	heat shock protein family A (Hsp70) member 4	Homo sapiens	46-51
34822480-5	2021	The cytoprotective mechanism of these peptides involves an improvement in the cellular antioxidant defense system, as indicated by the suppression of the intracellular ROS generation through upregulation of the cytoprotective enzyme heme oxygenase-1.	ros	168-171	heme oxygenase 1	Homo sapiens	233-249
34755672-9	2021	Chrysin treatment significantly reduced the generation of endogenous ROS, and treatment with N-Acetyl-L-cysteine to eliminate intracellular ROS obviously reduced the expressions of iNOS and COX-2 (P < 0.05) and blocked the AKT/mTOR pathway (P < 0.05).	ros	140-143	mechanistic target of rapamycin kinase	Mus musculus	227-231
34755672-10	2021	CONCLUSION: Chrysin can inhibit the synthesis of the upstream signaling molecule ROS to inhibit the activation of AKT/mTOR signaling pathway, regulate the translation process of ribosomes, down-regulate the synthesis and release of pro-inflammatory cytokines and inflammatory mediators, and thus produce anti-inflammatory effects.	ros	81-84	mechanistic target of rapamycin kinase	Mus musculus	118-122
34680394-8	2021	We also noted that MYCN inhibition results in reduction in glucose uptake, lactate production, ROS levels and gelatinolytic activity of active-MMP9, explaining a possible mechanism of MYCN in RB.	ros	95-98	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	19-23
34384953-0	2021	AZD8055 ameliorates experimental autoimmune encephalomyelitis via the mTOR/ROS/NLRP3 pathway.	ros	75-78	mechanistic target of rapamycin kinase	Mus musculus	70-74
34384953-0	2021	AZD8055 ameliorates experimental autoimmune encephalomyelitis via the mTOR/ROS/NLRP3 pathway.	ros	75-78	NLR family, pyrin domain containing 3	Mus musculus	79-84
34977433-4	2022	Herein, we design a ROS-responsive targeted micelle system (TT-NM/Rapa) to enhance the delivery efficiency of rapamycin to neurons in AD lesions guided by the fusion peptide TPL, and facilitate its intracellular release via ROS-mediated disassembly of micelles, thereby maximizing autophagic flux modulating efficacy of rapamycin in neurons.	ros	20-23	transcriptional regulating factor 1	Mus musculus	66-70
34251993-0	2021	SIZ1 regulates phosphate deficiency-induced inhibition of primary root growth of Arabidopsis by modulating Fe accumulation and ROS production in its roots.	ros	127-130	DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein	Arabidopsis thaliana	0-4
34190424-4	2021	BSO reduces intracellular glutathione levels to minimize ROS elimination and protein protection during PDT, and ZnPP inhibits the ROS-stimulated upregulation of the antioxidant HO-1, thus preventing ROS removal by cells after PDT.	ros	130-133	heme oxygenase 1	Homo sapiens	177-181
34190424-4	2021	BSO reduces intracellular glutathione levels to minimize ROS elimination and protein protection during PDT, and ZnPP inhibits the ROS-stimulated upregulation of the antioxidant HO-1, thus preventing ROS removal by cells after PDT.	ros	199-202	heme oxygenase 1	Homo sapiens	177-181
34246945-0	2021	H2S exposure induces cell death in the broiler thymus via the ROS-initiated JNK/MST1/FOXO1 pathway.	ros	62-65	macrophage stimulating 1 (hepatocyte growth factor-like)	Gallus gallus	80-84
34246945-6	2021	Proteomics analysis was used to reveal the toxicology of thymus injury in broilers, the FOXO signaling pathway was determined to be significantly enriched, ROS bursts and JNK/MST1/FOXO1 pathway activation induced by H2S exposure were detected, and ROS played an important switch role in the JNK/MST1/FOXO1 pathway.	ros	248-251	macrophage stimulating 1 (hepatocyte growth factor-like)	Gallus gallus	295-299
34584017-9	2021	On the one hand, the up-regulation of GPR43 gene reduced ROS mitochondrial damage to inhibit inflammatory reactions via the inactivation of NLRP3 Inflammasome by PPARgamma/ Nox1/EBP50/ p47phox signal channel.	ros	57-60	NLR family, pyrin domain containing 3	Mus musculus	140-145
34584017-9	2021	On the one hand, the up-regulation of GPR43 gene reduced ROS mitochondrial damage to inhibit inflammatory reactions via the inactivation of NLRP3 Inflammasome by PPARgamma/ Nox1/EBP50/ p47phox signal channel.	ros	57-60	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	178-183
34584017-9	2021	On the one hand, the up-regulation of GPR43 gene reduced ROS mitochondrial damage to inhibit inflammatory reactions via the inactivation of NLRP3 Inflammasome by PPARgamma/ Nox1/EBP50/ p47phox signal channel.	ros	57-60	neutrophil cytosolic factor 1	Mus musculus	185-192
34583974-0	2021	SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells.	ros	30-33	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	54-57
34577153-9	2021	Gas plasma is a physical state of matter and is a partially ionized gas operated at body temperature which generates a plethora of ROS/RNS simultaneously in a spatiotemporally controlled manner.	ros	131-134	gastrin	Homo sapiens	0-3
34577153-9	2021	Gas plasma is a physical state of matter and is a partially ionized gas operated at body temperature which generates a plethora of ROS/RNS simultaneously in a spatiotemporally controlled manner.	ros	131-134	gastrin	Homo sapiens	68-71
34342641-5	2021	In macrophages expressing ASCC171A, a mutant ASC without glutathionylation site, activation of NLRP3 inflammasome is GSTO1 independent, ROS independent, and signal 2 less dependent.	ros	136-139	NLR family, pyrin domain containing 3	Mus musculus	95-100
34489530-6	2021	Deletion of SDHD (Succinate dehydrogenase) gene from the complex II in the Substantia Nigra of Thy1-C/EBPbeta mice triggers ROS and PD pathologies, resulting in motor disorders.	ros	124-127	succinate dehydrogenase complex, subunit D, integral membrane protein	Mus musculus	12-16
34247042-0	2021	TGF-beta blockade-improved chemo-immunotherapy with pH/ROS cascade-responsive micelle via tumor microenvironment remodeling.	ros	55-58	transforming growth factor alpha	Mus musculus	0-8
34471469-5	2021	Pex14 knockdown disturbed peroxisomal biogenesis and dysregulated fatty acid metabolism and lipid storage capability, thereby increased ROS level and blunted insulin secretion.	ros	136-139	peroxisomal biogenesis factor 14	Rattus norvegicus	0-5
34382418-10	2021	CONCLUSION: Our results indicate that NDP52 promotes autophagic flux and clears damaged mitochondria to diminish ROS and cell death in a TBK1/RAB7-dependent manner and thus limits MI induced injury.	ros	113-116	TANK binding kinase 1	Homo sapiens	137-141
34394825-4	2021	We observed that AGEs treatment resulted in significantly increased apoptosis, senescence, and ROS accumulation in human NP cells; meanwhile, the enhanced apoptosis and senescence by AGEs treatment could be partially alleviated with the classic ROS scavenger NAC administration.	ros	95-98	synuclein alpha	Homo sapiens	259-262
34394825-4	2021	We observed that AGEs treatment resulted in significantly increased apoptosis, senescence, and ROS accumulation in human NP cells; meanwhile, the enhanced apoptosis and senescence by AGEs treatment could be partially alleviated with the classic ROS scavenger NAC administration.	ros	245-248	synuclein alpha	Homo sapiens	259-262
34235523-3	2021	In vitro studies revealed that this supramolecular DOX/NBS co-delivery system exhibited high ROS production and excellent cancer cell damage capability in a hypoxic environment.	ros	93-96	nibrin	Homo sapiens	55-58
34282120-6	2021	We further found that LPS induced the increase of cell surface TLR4 expression responsible for the production of ROS and subsequent parthanatos in endotoxemia.	ros	113-116	toll like receptor 4	Homo sapiens	63-67
34421346-9	2021	Suppression of CD147 expression increased the inhibitory effect of TMZ on cell survival in both U251 and T98G cells, whereas the gain of CD147 function blocked TMZ-induced ROS production and cell death.	ros	172-175	basigin (Ok blood group)	Homo sapiens	137-142
34307672-6	2021	PICK1 silencing significantly aggravated LPS-induced apoptosis, accompanied by ROS production in renal tubular epithelial cells.	ros	79-82	protein interacting with PRKCA 1	Homo sapiens	0-5
34307672-9	2021	In conclusion, PICK1 might protect renal tubular epithelial cells from LPS-induced apoptosis by reducing excessive ROS, making PICK1 a promising preventive target in LPS-induced AKI.	ros	115-118	protein interacting with PRKCA 1	Homo sapiens	15-20
34238104-8	2021	Moreover, the results of IHC showed that the miR-494 antagomir downregulated p65 NF-kappaB in kidney tissues from the LPS-induced AKI mice, accompanied by decreased levels of TNF-alpha, IL-1beta, IL-6, MDA, NO, and ROS but increased levels of SOD and GSH.	ros	215-218	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	77-90
34262322-13	2021	Conclusion: In conclusion, fisetin effectively protected against LPS-induced oxidative stress and inflammatory responses which may be closely correlated to inhibition of TLR4-mediated ROS/NF-kappaB and activation of the Nrf2/HO-1 pathway.	ros	184-187	toll like receptor 4	Bos taurus	170-174
34128315-8	2021	Mechanistically, CHOP deletion causes reduced ATF3 expression and further leads to decreased protein aggregation and ROS.	ros	117-120	DNA-damage inducible transcript 3	Mus musculus	17-21
34128315-10	2021	In summary, these findings disclose a new role of CHOP in the regulation of the HSCs function and homeostasis through reducing ATF3 and ROS signaling.	ros	136-139	DNA-damage inducible transcript 3	Mus musculus	50-54
34187410-0	2021	Osteopontin isoform c promotes the survival of cisplatin-treated NSCLC cells involving NFATc2-mediated suppression on calcium-induced ROS levels.	ros	134-137	nuclear factor of activated T cells 2	Homo sapiens	87-93
34187410-7	2021	Our study not only demonstrated the importance of OPN neutralization for anti-tumor effects, but also implied that modulation in calcium/NFATc2/ROS axis could be a novel approach for improving the long-term outcome of NSCLC treatment.	ros	144-147	nuclear factor of activated T cells 2	Homo sapiens	137-143
34176927-5	2021	In HeLa and 4T1 cells, LDHA or LDHB knockout or LDH inhibitor FX11 significantly decreased ROS induction by modulators of the mitochondrial electron transfer chain (antimycin, oligomycin, rotenone), hypoxia, and pharmacological ROS inducers piperlogumine (PL) and phenethyl isothiocyanate (PEITC).	ros	91-94	lactate dehydrogenase B	Mus musculus	31-35
34107901-15	2021	CONCLUSIONS: Our study showed that adiponectin ameliorated PA-induced podocyte injury in vitro and HFD-induced injury in vivo via inhibiting the ROS/NF-kappaB/NLRP3 pathway.	ros	145-148	NLR family, pyrin domain containing 3	Mus musculus	159-164
34177609-14	2021	Torin1 restored the decreased CTSL enzyme activity by removing excessive ROS and alleviated the effects of nicotine on mitophagic flux, mitochondrial dynamics, and apoptosis.	ros	73-76	cathepsin L	Rattus norvegicus	30-34
34112781-5	2021	Bacterial infection or LPS stimulation triggers assembly of the complex of Piezo1 and TLR4 to remodel F-actin organization and augment phagocytosis, mitochondrion-phagosomal ROS production and bacterial clearance and genetic deficiency of Piezo1 results in abrogation of these responses.	ros	174-177	piezo type mechanosensitive ion channel component 1	Homo sapiens	75-81
34112781-5	2021	Bacterial infection or LPS stimulation triggers assembly of the complex of Piezo1 and TLR4 to remodel F-actin organization and augment phagocytosis, mitochondrion-phagosomal ROS production and bacterial clearance and genetic deficiency of Piezo1 results in abrogation of these responses.	ros	174-177	toll like receptor 4	Homo sapiens	86-90
34065101-7	2021	The use of crocetin as a natural cross-linker significantly improved the in vitro ROS-scavenging ability of NPc with respect to NPg.	ros	82-85	NPC intracellular cholesterol transporter 1	Homo sapiens	108-111
34654876-8	2022	Furthermore, we showed that interrupting TRPV4-Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.	ros	218-221	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	41-46
34654876-8	2022	Furthermore, we showed that interrupting TRPV4-Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.	ros	218-221	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	152-157
35304783-7	2022	The expression of PGAM5 in JEG3 cells was up-regulated under hypoxia, which promoted dephosphorylation of Drp1 at Serine 637 residue, mitochondrial dysfunction (elevated ROS level and reduced mitochondrial membrane potential and ATP content) and cellular necroptosis (increased PI+ /Annexin V+ cells and decreased cell viability), accompanied by increased expression of necroptosis-relevant proteins; knockdown of PGAM5 attenuated these phenomena.	ros	170-173	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	18-23
35633418-3	2022	We have reported earlier that expression of human tau-transgene in Drosophila induces the expression of glob1, and its restored level restricts tau etiology by regulating tau hyperphosphorylation and ROS generation via GSK-3beta/p-Akt and Nrf2-keap1-ARE pathways, respectively.	ros	200-203	microtubule associated protein tau	Homo sapiens	50-53
35633418-3	2022	We have reported earlier that expression of human tau-transgene in Drosophila induces the expression of glob1, and its restored level restricts tau etiology by regulating tau hyperphosphorylation and ROS generation via GSK-3beta/p-Akt and Nrf2-keap1-ARE pathways, respectively.	ros	200-203	microtubule associated protein tau	Homo sapiens	144-147
35624400-8	2022	RESULTS: TRX may play a role in OSAHS by scavenging ROS, blocking the production of inflammatory cytokines, inhibiting the migration and activation of neutrophils, and controlling the activation of ROS-dependent inflammatory signals by regulating the redox state of intracellular target particles.	ros	198-201	thioredoxin	Homo sapiens	9-12
35472411-3	2022	There is a significant body of research investigating the effects of oxidative stress/ROS on ASM behaviour, falling into the following categories; cigarette smoke and associated compounds, air pollutants, aero-allergens, asthma and COPD relevant mediators, and the anti-oxidant Nrf2/HO-1 signalling pathway.	ros	86-89	H19 imprinted maternally expressed transcript	Homo sapiens	93-96
35472411-3	2022	There is a significant body of research investigating the effects of oxidative stress/ROS on ASM behaviour, falling into the following categories; cigarette smoke and associated compounds, air pollutants, aero-allergens, asthma and COPD relevant mediators, and the anti-oxidant Nrf2/HO-1 signalling pathway.	ros	86-89	heme oxygenase 1	Homo sapiens	283-287
35556218-7	2022	In addition, ODN decreased ROS by generating less oxidants and more antioxidants, as reflected by a dramatic increase in total antioxidant capacity, glutathione reductase, and catalase and a marked decrease in H2O2 and total nitric oxide synthase.	ros	27-30	glutathione-disulfide reductase	Rattus norvegicus	149-170
35624809-11	2022	Furthermore, analog 2 not only reduced ROS levels, which induce melanogenesis, but it also suppressed tyrosinase and MITF (microphthalamia-associated transcription factor) protein levels and the expressions of melanogenesis-related genes.	ros	39-42	tyrosinase	Mus musculus	102-112
35624809-11	2022	Furthermore, analog 2 not only reduced ROS levels, which induce melanogenesis, but it also suppressed tyrosinase and MITF (microphthalamia-associated transcription factor) protein levels and the expressions of melanogenesis-related genes.	ros	39-42	melanocyte inducing transcription factor	Homo sapiens	117-121
35534546-5	2022	Here, we show that the activation of the Wnt/beta-catenin signaling attenuates cellular lipid ROS production and subsequently inhibits ferroptosis in GC cells.	ros	94-97	catenin beta 1	Homo sapiens	45-57
35521658-5	2022	Removal of domains is necessary for ATF3/Tip60 binding compromises RGS7-dependent ROS generation and cell death.	ros	82-85	activating transcription factor 3	Homo sapiens	36-40
35566338-0	2022	ST2825, a Small Molecule Inhibitor of MyD88, Suppresses NF-kappaB Activation and the ROS/NLRP3/Cleaved Caspase-1 Signaling Pathway to Attenuate Lipopolysaccharide-Stimulated Neuroinflammation.	ros	85-88	NLR family, pyrin domain containing 3	Mus musculus	89-94
35247918-2	2022	Herein, we explored the therapeutic potential to enhance chemotherapy response in AML, by targeting the ROS scavenger enzyme MutT homolog 1 (MTH1, NUDT1), which protects cellular integrity through prevention of fatal chemotherapy-induced oxidative DNA damage.	ros	104-107	nudix hydrolase 1	Homo sapiens	125-139
35247918-2	2022	Herein, we explored the therapeutic potential to enhance chemotherapy response in AML, by targeting the ROS scavenger enzyme MutT homolog 1 (MTH1, NUDT1), which protects cellular integrity through prevention of fatal chemotherapy-induced oxidative DNA damage.	ros	104-107	nudix hydrolase 1	Homo sapiens	141-145
35506610-12	2022	We observed consistency in the expression of two genes (GSR and CAT) related to ROS scavenging in the late phase of pre-germinative metabolism.	ros	80-83	catalase-1	Triticum aestivum	64-67
35615982-10	2022	CDC25C inhibition increases the accumulation of ROS, inhibits mitochondrial respiration, suppresses glycolysis metabolism and reduces GSH levels.	ros	48-51	cell division cycle 25C	Homo sapiens	0-6
35417750-9	2022	In conclusion, P. bovis induced an inflammatory response via the NF-kappaB/NLRP3 inflammasome pathway; however, scavenging ROS or activating Nrf2 mitigated the inflammatory response in infected mMECs.	ros	123-126	NLR family, pyrin domain containing 3	Mus musculus	75-80
35460170-7	2022	CIT improves cell metabolic activity, decreases ROS production, limits lipid peroxidation, reduces cell death and attenuates IL-8 secretion.	ros	48-51	citron rho-interacting serine/threonine kinase	Homo sapiens	0-3
35180474-6	2022	High-resolution respirometry of transiently transfected HAP1-DeltaVDAC3 cells expressing the wild type or the cysteine-null mutant VDAC3 protein, unequivocally confirmed that VDAC3 cysteines are indispensable for protein ability to counteract ROS-induced oxidative stress.	ros	243-246	voltage dependent anion channel 3	Homo sapiens	131-136
35457246-9	2022	SAG significantly restored SOD activity, GSH levels and GPx activity, while it strongly reduced GSSG levels, lipid peroxidation and H2O2 and ROS levels in the liver.	ros	141-144	S-antigen, retina and pineal gland (arrestin)	Mus musculus	0-3
35432536-9	2022	The levels of lipid ROS and iron were promoted by the treatment of erastin and the overexpression of KAT6B could reverse the effect in the cells.	ros	20-23	lysine acetyltransferase 6B	Homo sapiens	101-106
35085814-9	2022	Taken together, our results indicate that c-Myc-mediated mitochondrial fragmentation promotes malignant transformation and progression of HB by activating ROS-mediated multi-oncogenic signaling.	ros	155-158	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-47
35217429-6	2022	Sperm exposed to different concentrations of IFNgamma, IL-17A and IL-1beta, or a combination of them, for either 1 or 3 h showed significantly increased levels of mitochondrial ROS production and reduced motility and viability with respect to sperm incubated with vehicle.	ros	177-180	interleukin 1 alpha	Homo sapiens	66-74
35217429-9	2022	In conclusion, our results indicate that IFNgamma, IL-17A and IL-1beta per se impair sperm motility and decreases viability by triggering increased mitochondrial ROS production and inducing sperm apoptosis.	ros	162-165	interleukin 1 alpha	Homo sapiens	62-70
35402865-2	2022	Here we show that intracellular Ca2+ ((Ca2+)i) and ROS signals generated by high glucose and cytokine-induced ER stress activate calcineurin (CN)/NFATc2 and PI3K/AKT to maintain beta-cell identity and function.	ros	51-54	nuclear factor of activated T cells 2	Homo sapiens	146-152
35370642-9	2022	Experimental results found that SSD suppressed IL-1beta-induced differentiated ATDC 5 chondrocytes apoptosis via the Nrf2/HO-1/ROS axis in vitro.	ros	127-130	interleukin 1 alpha	Mus musculus	47-55
35122867-13	2022	In summary, Ce6 PDT damages DNA, up-regulates GPX4 to degrade ROS, thereby inducing drug resistance.	ros	62-65	glutathione peroxidase 4	Homo sapiens	46-50
35328073-5	2022	RESULTS: In HARD cases, the most significant (p < 0.05) associations were for m.295C>T (control region) and m.12612A>G (ND5), found more frequently in cases (OR = 1.05), potentially related to reduced cardiorespiratory fitness in response to exercise, as well as for m.12372G>A (ND5) and m.11467A>G (ND4), present more frequently in controls (OR = 0.97), previously associated with lower ROS production rate.	ros	388-391	mitochondrially encoded NADH dehydrogenase 5	Homo sapiens	120-123
35263214-10	2022	The expression level of IL-1beta and IL-18 was promoted as the aggravation of hypoxia, accompanied by the elevated production of LDH and ROS.	ros	137-140	interleukin 18	Rattus norvegicus	37-42
35352250-3	2022	The association of the minor allele rs1046495-C with type 2 diabetes mellitus can be explained by its more pronounced effect on the expression of the GFER enzyme that through glutathionation maintains the ROS level for optimal functioning of complexes III and IV of the electron transport chain and promotes the formation of disulfide bonds in the CHCHD4 chaperone molecule.	ros	205-208	growth factor, augmenter of liver regeneration	Homo sapiens	150-154
35074488-8	2022	NAC, a ROS scavenger, rescued DHT-induced proliferation inhibition, ROS generation and Nrf2 inhibition.	ros	7-10	synuclein alpha	Homo sapiens	0-3
35074488-8	2022	NAC, a ROS scavenger, rescued DHT-induced proliferation inhibition, ROS generation and Nrf2 inhibition.	ros	68-71	synuclein alpha	Homo sapiens	0-3
35157764-12	2022	ClpP activation by both drugs results in impaired tumor cell metabolism, mitochondrial damage, ROS production, activation of integrative stress response and apoptosis in vitro and in vivo.	ros	95-98	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Homo sapiens	0-4
35204227-9	2022	In addition, treatment of TGEV-infected IPEC-J2 cells with the ROS inhibitors (NAC) significantly reduced the protein levels of p-P38MAPK, Fas, Bax, and Cleaved-caspase-3 and the percentage of apoptotic cells.	ros	63-66	apoptosis regulator BAX	Sus scrofa	144-147
35123567-16	2022	CONCLUSION: The dual role of HIF1alpha in osteogenesis-angiogenesis coupling may depend on the ROS-mediated HIF1alpha-p53 relationship.	ros	95-98	hypoxia inducible factor 1, alpha subunit	Mus musculus	29-38
35123567-16	2022	CONCLUSION: The dual role of HIF1alpha in osteogenesis-angiogenesis coupling may depend on the ROS-mediated HIF1alpha-p53 relationship.	ros	95-98	hypoxia inducible factor 1, alpha subunit	Mus musculus	108-117
35123567-16	2022	CONCLUSION: The dual role of HIF1alpha in osteogenesis-angiogenesis coupling may depend on the ROS-mediated HIF1alpha-p53 relationship.	ros	95-98	transformation related protein 53, pseudogene	Mus musculus	118-121
35204757-8	2022	In addition, RANKL-induced activation of MAPK, ER stress, and ROS levels in RANKL-induced osteoclast was significantly inhibited while antioxidant enzymes were recovered in the presence of AD.	ros	62-65	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	13-18
35204757-8	2022	In addition, RANKL-induced activation of MAPK, ER stress, and ROS levels in RANKL-induced osteoclast was significantly inhibited while antioxidant enzymes were recovered in the presence of AD.	ros	62-65	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	76-81
35075150-8	2022	The aforementioned miR-181a-2-3p shuttled by MSC-derived EVs facilitated SH-SY5Y proliferation and SOD levels, but suppressed apoptosis and MDA and ROS levels by regulating EGR1 via inhibition of NOX4/p38 MAPK, so as to repress OS of PD.	ros	148-151	early growth response 1	Homo sapiens	173-177
35082967-7	2022	On the contrary, mimic expressions of miR-126 prominently reduced caspase-3 activity and intracellular ROS levels and markedly enhanced HUVEC cellular viabilities (P < 0.001).	ros	103-106	microRNA 126	Homo sapiens	38-45
35052632-0	2022	Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium.	ros	107-110	activity dependent neuroprotector homeobox	Homo sapiens	0-42
35052632-0	2022	Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium.	ros	107-110	activity dependent neuroprotector homeobox	Homo sapiens	44-48
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	ros	150-153	NLR family, pyrin domain containing 3	Mus musculus	222-227
35035661-8	2022	Notably, when LPS/ATP-stimulated RAW264.7 macrophages were treated with CoQ0, Mito-TEMPO (a mitochondrial ROS inhibitor), or N-acetylcysteine (NAC, a ROS inhibitor), there was a significant reduction of LPS/ATP-stimulated NLRP3 inflammasome activation and IL1beta expression.	ros	150-153	interleukin 1 alpha	Mus musculus	256-263
35002432-10	2022	Moreover, the combined effect of scutellarin and JNK inhibitor SP600125 on the levels of ROS and the SOD activity followed a similar trend to that of scutellarin alone albeit with a lower magnitude of change.	ros	89-92	mitogen-activated protein kinase 8	Rattus norvegicus	49-52
23308066-0	2012	COX5B regulates MAVS-mediated antiviral signaling through interaction with ATG5 and repressing ROS production.	ros	95-98	mitochondrial antiviral signaling protein	Homo sapiens	16-20
23308066-6	2012	Mechanistically, we find that while activation of MAVS leads to increased ROS production and COX5B expression, COX5B down-regulated MAVS signaling by repressing ROS production.	ros	74-77	mitochondrial antiviral signaling protein	Homo sapiens	50-54
23308066-6	2012	Mechanistically, we find that while activation of MAVS leads to increased ROS production and COX5B expression, COX5B down-regulated MAVS signaling by repressing ROS production.	ros	161-164	mitochondrial antiviral signaling protein	Homo sapiens	132-136
23099819-8	2012	Attenuated ROS in ecSOD Tg myocytes was also supported by decreased production of peroxynitrite (ONOO(-)).	ros	11-14	superoxide dismutase 3, extracellular	Mus musculus	18-23
23099819-10	2012	In conclusion, attenuation of ROS levels by cardiac-specific ecSOD overexpression increases NO bioavailability in response to ischemia/reperfusion and protects against reperfusion injury.	ros	30-33	superoxide dismutase 3, extracellular	Mus musculus	61-66
23099819-11	2012	These findings are the first to demonstrate increased NO bioavailability with attenuation of ROS by direct measurement of these reactive species (EPR, reactive fluorescent dyes) with cardiac-specific ecSOD expression.	ros	93-96	superoxide dismutase 3, extracellular	Mus musculus	200-205
22982676-10	2012	RESULTS: Palmitate increased ROS production in GLP-1 secreting cells, and the lipotoxic effects of palmitate were abolished in the presence of the antioxidant Trolox.	ros	29-32	zinc finger, GATA-like protein 1	Mus musculus	47-52
22982676-13	2012	CONCLUSION: This study demonstrates that palmitate induces ROS production and that the palmitate induced lipotoxicity is the result of increased ROS production, where the ROS sensitive MKK3/6-p38 pathway mediates lipoapoptosis of GLP-1-secreting cells.	ros	145-148	zinc finger, GATA-like protein 1	Mus musculus	230-235
22982676-13	2012	CONCLUSION: This study demonstrates that palmitate induces ROS production and that the palmitate induced lipotoxicity is the result of increased ROS production, where the ROS sensitive MKK3/6-p38 pathway mediates lipoapoptosis of GLP-1-secreting cells.	ros	145-148	zinc finger, GATA-like protein 1	Mus musculus	230-235
22898050-14	2012	Inhibiting AMPK and PTEN restored ROS levels stimulated with TNF-alpha.	ros	34-37	phosphatase and tensin homolog	Homo sapiens	20-24
22718806-2	2012	The objective of our study was to determine whether chronic IL-17 increases blood pressure by stimulating ROS and AT1-AAs during pregnancy.	ros	106-109	interleukin 17A	Rattus norvegicus	60-65
22718806-14	2012	MAP was 105 +- 5 mmHg and ROS was 418 +- 5 RLU ml(-1) min(-1) in NP+IL 17-treated with losartan.	ros	26-29	interleukin 17A	Rattus norvegicus	68-73
22552773-0	2012	Ethanol induction of CYP2A5: role of CYP2E1-ROS-Nrf2 pathway.	ros	44-47	cytochrome P450, family 2, subfamily e, polypeptide 1	Mus musculus	37-43
22562073-7	2012	Such inhibition of ROS prevented the processing and release of AIF (apoptosis-inducing factor) and HTRA2 from mitochondria.	ros	19-22	HtrA serine peptidase 2	Homo sapiens	99-104
22618235-7	2012	The general patterns of FKBP12 and FKBP12.6 mRNA expression showed upregulation after hypoxia, downregulation after ischemia and normalization after reperfusion, which was partially attenuated if ROS was added during HEDA.	ros	196-199	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	24-30
22350156-5	2012	The expressions of AtP5CS and AtZAT12 which mirror the activities of proline and ascorbate peroxidase synthesis respectively were induced in TaMYB33 over-expression lines, indicating TaMYB33 promotes the ability for osmotic pressure balance-reconstruction and reactive oxidative species (ROS) scavenging.	ros	288-291	transcription factor MYB30	Triticum aestivum	141-148
22350156-5	2012	The expressions of AtP5CS and AtZAT12 which mirror the activities of proline and ascorbate peroxidase synthesis respectively were induced in TaMYB33 over-expression lines, indicating TaMYB33 promotes the ability for osmotic pressure balance-reconstruction and reactive oxidative species (ROS) scavenging.	ros	288-291	transcription factor MYB30	Triticum aestivum	183-190
22350156-7	2012	These results suggest that TaMYB33 enhances salt and drought tolerance partially through superior ability for osmotic balance reconstruction and ROS detoxification.	ros	145-148	transcription factor MYB30	Triticum aestivum	27-34
22622822-6	2012	ROS are involved in mediating the vulnerability of APP/PS1 neurons to iAbeta toxicity.	ros	0-3	presenilin 1	Mus musculus	55-58
22708121-2	2012	ROS production is commonly involved in the pathogenesis of skin damage induced by these factors, causing skin aging, including wrinkling, by activating the metalloproteinases (MMP-1) that break down type I collagen (COL1A1).	ros	0-3	matrix metallopeptidase 1	Homo sapiens	176-181
22506638-5	2012	Compounds 2, 6, and 7 showed the highest antioxidant capacity and ability to affect the levels of intracellular ROS in human prostate cancer cells (PC3).	ros	112-115	chromobox 8	Homo sapiens	148-151
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	188-191	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	47-52
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	188-191	FBJ osteosarcoma oncogene	Mus musculus	68-73
25514461-8	2014	In contrast, significant negative correlations of some ROS and HSP70 characteriscics were found for neutrophils from young people and nonagenarians.	ros	55-58	heat shock protein family A (Hsp70) member 4	Homo sapiens	63-68
22306819-7	2012	In addition, we found that SIRT1 maintains prematurity of hematopoietic cells through ROS elimination, FOXO activation, and p53 inhibition.	ros	86-89	sirtuin 1	Mus musculus	27-32
29805908-12	2014	We also found that Abeta42 increased P-selectin fluorescence at the surface of bEnd3 cells in a time dependent manner in parallel to ROS elevation.	ros	133-136	BEN domain containing 3	Mus musculus	79-84
29805908-18	2014	Conclusions: The results of our study have indicated that Abeta42 induced accumulation of P-selectin on the surface of bEnd3 cells and promoted actin polymerization, and all these events were correlated with ROS generation.	ros	208-211	BEN domain containing 3	Mus musculus	119-124
21902595-5	2012	Moreover, regulation of Oct4 by Ago2 directly controls the stem cell plasticity-determining signal mediators JAK2/STAT3 and Wnt5A/beta-catenin and positively regulates cell proliferation and differentiation via blockage of ROS generation and P38/JNK inactivation.	ros	223-226	POU class 5 homeobox 1	Homo sapiens	24-28
25476909-4	2014	Moreover, NADPH, generated by both the pentose phosphate pathway and the cancer-specific serine glycolytic diversion, appears to sustain glutamine utilization for amino-acid synthesis, lipid synthesis, and for ROS quenching.	ros	210-213	2,4-dienoyl-CoA reductase 1	Homo sapiens	10-15
21902595-8	2012	INNOVATION AND CONCLUSION: This study reveals that nuclear Ago2 globally controls stem cell self-renewal and differentiation through direct regulation of stemness genes and important signal mediator activation following inactivation of ROS/P38/JNK and activation of the JAK/STAT3 and Wnt/ beta-catenin signal pathways.	ros	236-239	catenin beta 1	Homo sapiens	289-301
22223094-0	2012	Brain and muscle ARNT-like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to hypoxia-inducible factor-mediated pathway.	ros	51-54	aryl hydrocarbon receptor nuclear translocator	Homo sapiens	17-21
25229402-13	2014	In conclusion, our findings demonstrated that Smad3-Nox4 axis-mediated mitochondrial dysfunction is involved in PA-induced podocyte damage likely via increasing ROS generation and activating the cytochrome c-caspase9-caspase3 apoptotic signaling pathway.	ros	161-164	NADPH oxidase 4	Rattus norvegicus	52-56
22739135-4	2012	Forced expression of MCPIP in 3T3-L1 preadipocytes caused increased reactive oxygen/nitrogen species (ROS/RNS) production and inducible-nitric oxide synthase (iNOS) expression, endoplasmic reticulum stress (ER), as indicated by expression of ER chaperones and protein disulfide isomerase, and autophagy as indicated by expression of beclin-1 and cleavage of LC3.	ros	102-105	zinc finger CCCH-type containing 12A	Homo sapiens	21-26
25269472-9	2014	Collectively, our data indicate that cisplatin resistance in HOCCs is partially attributable to their high expression of p62, which plays an important role in preventing ROS stress-induced apoptosis by regulating the Keap1-Nrf2-ARE signaling pathway.	ros	170-173	sequestosome 1	Homo sapiens	121-124
22739135-5	2012	Treatment of ROS inhibitor, apocynin attenuated MCPIP induction of adipogenesis as measured by the induction of transcription factors involved in adipogenesis, adipocyte markers and lipid droplet accumulation.	ros	13-16	zinc finger CCCH-type containing 12A	Homo sapiens	48-53
25429618-2	2014	Postischemic ROS generation and an increase in the cytosolic Zn(2+) level ([Zn(2+)]c) are critical in delayed CA1 pyramidal neuronal death, but the underlying mechanisms are not fully understood.	ros	13-16	carbonic anhydrase 1	Homo sapiens	110-113
22007260-4	2012	Rhein induced dose- and time-dependent manners increase in caspase-9-mediated apoptosis correlating with activation of ROS-mediated activation of NF-kappaB- and p53-signaling pathways in both cell types.	ros	119-122	caspase 9	Homo sapiens	59-68
25429618-3	2014	Here we investigated the role of ROS-sensitive TRPM2 (transient receptor potential melastatin-related 2) channel.	ros	33-36	transient receptor potential cation channel subfamily M member 2	Homo sapiens	47-52
25429618-3	2014	Here we investigated the role of ROS-sensitive TRPM2 (transient receptor potential melastatin-related 2) channel.	ros	33-36	transient receptor potential cation channel subfamily M member 2	Homo sapiens	54-103
25429618-4	2014	Using in vivo and in vitro models of ischemia-reperfusion, we showed that genetic knockout of TRPM2 strongly prohibited the delayed increase in the [Zn(2+)]c, ROS generation, CA1 pyramidal neuronal death and postischemic memory impairment.	ros	159-162	transient receptor potential cation channel subfamily M member 2	Homo sapiens	94-99
25520856-5	2014	The accumulated ROS induced DNA damage response (DDR), that mediated Chk1/Chk2 upregulation and activation which were essential factors for the G0/G1 arrest.	ros	16-19	checkpoint kinase 1	Mus musculus	69-73
25520856-6	2014	NAC-mediated scavenging of ROS generation reduced the propensity of G0/G1 phase arrest in GBM cells by mahanine.	ros	27-30	NLR family, pyrin domain containing 1A	Mus musculus	0-3
22201839-5	2012	The mechanism activated by POX is mediated by its production of ROS.	ros	64-67	proline dehydrogenase 1	Homo sapiens	27-30
25044446-8	2014	Further, the effects of oxHDL for the enhanced formation of MMP-9 were found to be mediated by NADPH oxidase/ROS-JNK/ERK pathway, as one mechanism.	ros	109-112	matrix metallopeptidase 9	Homo sapiens	60-65
25064608-0	2014	Induction of hepatoma carcinoma cell apoptosis through activation of the JNK-nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-ROS self-driven death signal circuit.	ros	137-140	2,4-dienoyl-CoA reductase 1	Homo sapiens	73-136
25064608-1	2014	As an efficient method for inducing tumor cell apoptosis, ROS can be constantly formed and accumulated in NADPH oxidase overactivated-cells, resulting in further mitochondrial membrane damage and mitochondria-dependent apoptosis.	ros	58-61	2,4-dienoyl-CoA reductase 1	Homo sapiens	106-111
25064608-3	2014	However, the relationship between NADPH oxidase-ROS and JNK MAPK signal still remains unclear.	ros	48-51	2,4-dienoyl-CoA reductase 1	Homo sapiens	34-39
25064608-4	2014	Here, we discovered a novel self-driven signal circuit between NADPH oxidase-ROS and JNK MAPK, which was induced by a cytotoxic steroidal saponin (ASC) in hepatoma carcinoma cells.	ros	77-80	2,4-dienoyl-CoA reductase 1	Homo sapiens	63-68
22474400-8	2012	Magnolol significantly (P &lt; 0.05) decreased the production of osteoclast differentiation inducing factors such as RANKL, TNF-alpha, and IL-6 in the presence of antimycin A, which inhibits mitochondrial electron transport and has been used as an ROS generator.	ros	248-251	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	117-122
25064608-5	2014	NADPH oxidase-dependent ROS production was markedly activated by ASC and directly led to JNK MAPK activation.	ros	24-27	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
25064608-6	2014	Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK.	ros	141-144	2,4-dienoyl-CoA reductase 1	Homo sapiens	23-28
22829775-3	2012	Using a panel of GFP-fused stress response genes, we identified the suites of cytoprotective pathways upregulated by 160 gene inactivations known to increase Caenorhabditis elegans longevity, including the mitochondrial UPR (hsp-6, hsp-60), the ER UPR (hsp-4), ROS response (sod-3, gst-4), and xenobiotic detoxification (gst-4).	ros	261-264	Chaperonin homolog Hsp-60, mitochondrial	Caenorhabditis elegans	232-238
22880044-7	2012	RESULTS: Pre-treatment of Tbeta4 resulted in reduction of the intracellular ROS levels induced by H(2)O(2) in cardiomyocytes.	ros	76-79	thymosin beta 4, X-linked	Rattus norvegicus	26-32
24997047-2	2014	In cases of glucose 6-phosphate dehydrogenase (G6PD) deficiency, under conditions of oxidative stress, the residual G6PD and complimentary antioxidant mechanisms may become insufficient to neutralize the large amounts of ROS and to prevent severe hemolysis.	ros	221-224	glucose-6-phosphate dehydrogenase	Homo sapiens	47-51
25247304-9	2014	Over-expression of let-7a and let-7b inhibited the oxLDL-induced endothelial cell apoptosis, NO deficiency, ROS over-production, LOX-1 upregulation and endothelial nitric oxide synthase (eNOS) downregulation.	ros	108-111	microRNA let-7b	Homo sapiens	30-36
22911747-6	2012	ROS production in Top1mt-/- MEF cells is involved in nuclear DNA damage and induction of autophagy.	ros	0-3	DNA topoisomerase 1, mitochondrial	Mus musculus	18-24
24971480-0	2014	Phosphorylation of H3 serine 10 by IKKalpha governs cyclical production of ROS in estrogen-induced transcription and ensures DNA wholeness.	ros	75-78	component of inhibitor of nuclear factor kappa B kinase complex	Homo sapiens	35-43
22072715-6	2011	Knockdown of PTEN with siRNA abrogated the effects of PPARdelta on cellular senescence, on PI3K/Akt signaling, and on generation of ROS in VSMCs treated with Ang II.	ros	132-135	phosphatase and tensin homolog	Homo sapiens	13-17
25218094-4	2014	Mixture of Cd and BDE-209 has shown clear potential to reduce the viability of SW 480 cells, as evidenced by cytotoxicity associated with ROS generation.	ros	138-141	homeobox D13	Homo sapiens	18-21
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	44-47	FAM20C golgi associated secretory pathway kinase	Homo sapiens	48-51
24990602-3	2014	In fact, TRAP1: i) contributes to the tumor"s switch to aerobic glycolysis through the inhibition of succinate dehydrogenase, the complex II of the mitochondrial respiratory chain; ii) is part of a pro-survival signaling pathway aimed at evading the toxic effects of oxidants and anticancer drugs and protects mitochondria against damaging stimuli via a decrease of ROS generation; iii) controls protein homeostasis through a direct involvement in the regulation of protein synthesis and protein co-translational degradation.	ros	366-369	TNF receptor associated protein 1	Homo sapiens	9-14
25101674-7	2014	N-acetyl-L-cysteine (NAC) and 3-methyladenine (3-MA) attenuated DSTD-induced autophagy but promoted cell death, suggesting that DSTD induced ROS-mediated autophagy to rescue cell death.	ros	141-144	X-linked Kx blood group	Homo sapiens	21-24
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	44-47	FAM20C golgi associated secretory pathway kinase	Homo sapiens	307-310
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	303-306	FAM20C golgi associated secretory pathway kinase	Homo sapiens	48-51
21303349-2	2011	Similarly reactive oxygen/nitrogen species (ROS/RNS) produced during normal metabolic activities, specifically oxidative phosphorylation of the cell, are scavenged by antioxidant enzymes like superoxide dismutase (SOD), catalase but impaired metabolic pathways tend to generate elevated levels of these ROS/RNS.	ros	303-306	FAM20C golgi associated secretory pathway kinase	Homo sapiens	307-310
24582363-4	2014	It was shown that CS2 exposure impaired ultrastructure of germ cells, increased the numbers of apoptotic germ cells, accumulated intracellular level of calcium, elevated ROS level, and increased activities of complexes of respiratory chain.	ros	170-173	calsyntenin 2	Rattus norvegicus	18-21
21303349-4	2011	This review summarizes the mechanism of ROS/RNS production and their role in lipid peroxidation.	ros	40-43	FAM20C golgi associated secretory pathway kinase	Homo sapiens	44-47
21898090-5	2011	Also, GKN1-transfected and recombinant GKN1-treated AGS cells showed decreased levels of ROS and expression of phosphatidylinositol 3-kinase (PI3K)/Akt pathway proteins, concomitant with re-expression of E-cadherin and decreased expression of cytoplasmic and nuclear expression of beta-catenin, slug, snail, fibronectin, and vimentin.	ros	89-92	gastrokine 1	Homo sapiens	6-10
24518876-8	2014	Down-regulation of Mfn2 with siRNA in 293T cells induced significant mitochondrial dysfunction including decreased oxygen consumption, decreased ATP production, and increased ROS production, followed by increased triglyceride content suggesting a contributing role of decreased mitochondrial fusion to lipid deposit.	ros	175-178	mitofusin 2	Homo sapiens	19-23
21898090-5	2011	Also, GKN1-transfected and recombinant GKN1-treated AGS cells showed decreased levels of ROS and expression of phosphatidylinositol 3-kinase (PI3K)/Akt pathway proteins, concomitant with re-expression of E-cadherin and decreased expression of cytoplasmic and nuclear expression of beta-catenin, slug, snail, fibronectin, and vimentin.	ros	89-92	gastrokine 1	Homo sapiens	39-43
21390502-2	2011	8-oxoguanine DNA glycosylase-1 (OGG1) is an enzyme involved in base excision repair of 8-oxoguanine that is one of the premutagenic lesions generated by ROS in DNA.	ros	153-156	8-oxoguanine DNA glycosylase	Homo sapiens	0-30
21390502-2	2011	8-oxoguanine DNA glycosylase-1 (OGG1) is an enzyme involved in base excision repair of 8-oxoguanine that is one of the premutagenic lesions generated by ROS in DNA.	ros	153-156	8-oxoguanine DNA glycosylase	Homo sapiens	32-36
21664458-7	2011	Furthermore, we showed that SIRT3 positively regulated both mitochondrial oxidative capacity and antioxidant gene expression, thereby reducing ROS accumulation in mProx cells, which suggests a mechanism that underlies SIRT3-mediated reversal of palmitate-induced inflammation.	ros	143-146	sirtuin 3	Mus musculus	28-33
21664458-7	2011	Furthermore, we showed that SIRT3 positively regulated both mitochondrial oxidative capacity and antioxidant gene expression, thereby reducing ROS accumulation in mProx cells, which suggests a mechanism that underlies SIRT3-mediated reversal of palmitate-induced inflammation.	ros	143-146	sirtuin 3	Mus musculus	218-223
21664458-8	2011	In conclusion, these results highlight a new role for SIRT3 in lipotoxicity/ROS-related inflammation, reveal a new molecular mechanism underlying calorie restriction-mediated antioxidant and anti-inflammatory effects, and could aid in the design of new therapies for the prevention of tubulointerstitial lesions in proteinuric kidney disease.	ros	76-79	sirtuin 3	Mus musculus	54-59
21425328-11	2011	In conclusion, ROS dependent-ATM/p53 signaling pathway is involved in HMJ-30-induced apoptosis in U-2 OS cells.	ros	15-18	ATM serine/threonine kinase	Homo sapiens	29-32
21664494-3	2011	Both PINK1- and DJ-1-deficient dopaminergic neurons had the increased production of ROS, severe mitochondrial structural damages and complex I deficits.	ros	84-87	Parkinsonism associated deglycase	Homo sapiens	16-20
22108328-6	2011	Furthermore, the inhibition of ROS and apoptosis after POX siRNA used in troglitazone-treated HT29 cells indicated that POX be essential in the ROS formation and PPARgamma-dependent apoptosis induced by troglitazone.	ros	31-34	proline dehydrogenase 1	Homo sapiens	120-123
22108328-6	2011	Furthermore, the inhibition of ROS and apoptosis after POX siRNA used in troglitazone-treated HT29 cells indicated that POX be essential in the ROS formation and PPARgamma-dependent apoptosis induced by troglitazone.	ros	144-147	proline dehydrogenase 1	Homo sapiens	55-58
22108328-6	2011	Furthermore, the inhibition of ROS and apoptosis after POX siRNA used in troglitazone-treated HT29 cells indicated that POX be essential in the ROS formation and PPARgamma-dependent apoptosis induced by troglitazone.	ros	144-147	proline dehydrogenase 1	Homo sapiens	120-123
22108328-7	2011	CONCLUSION: The findings from this study showed that troglitazone-induced apoptosis was mediated by POX-induced ROS formation, at least partly, via PPARgamma activation.	ros	112-115	proline dehydrogenase 1	Homo sapiens	100-103
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	60-63	epidermal growth factor	Homo sapiens	15-18
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	60-63	epidermal growth factor	Homo sapiens	129-132
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	epidermal growth factor	Homo sapiens	15-18
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	epidermal growth factor	Homo sapiens	129-132
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	epidermal growth factor	Homo sapiens	15-18
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	epidermal growth factor	Homo sapiens	129-132
23554696-8	2011	Our study demonstrated that EGF-induced cell migration involves a cascade of signalling events, including activation of Rac1, generation of ROS and subsequent activation of PI3K/Akt and PAK1.	ros	140-143	epidermal growth factor	Homo sapiens	28-31
21194832-6	2011	Furthermore, we show that Rh2 increased ROS levels and activated the NF-kappaB survival pathway.	ros	40-43	Rh associated glycoprotein	Homo sapiens	26-29
21194832-7	2011	Blockage of ROS by NAC or catalase inhibited the activation of NF-kappaB signaling and enhanced Rh2-induced cell death, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants.	ros	12-15	Rh associated glycoprotein	Homo sapiens	96-99
21194832-7	2011	Blockage of ROS by NAC or catalase inhibited the activation of NF-kappaB signaling and enhanced Rh2-induced cell death, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants.	ros	12-15	Rh associated glycoprotein	Homo sapiens	162-165
21304825-9	2011	Inhibition of TNFalpha expression dramatically reduced the Bad/Bid-mediated apoptotic and Rip1/ROS-mediated necrotic cell death pathways and rescued host cell viability.	ros	95-98	receptor interacting serine/threonine kinase 1	Homo sapiens	90-94
21304825-11	2011	The Rip1/ROS-mediated secondary necrotic pathway appeared to be reduced in IPNV-infected fish cells during the middle-late stage of infection (12-18 h p.i.).	ros	9-12	receptor interacting serine/threonine kinase 1	Homo sapiens	4-8
21779360-8	2011	Notably, NAC, a ROS scavenger, conferred a similar protective effect of H(2)S against CoCl(2)-induced insults and inflammatory responses.	ros	16-19	synuclein alpha	Homo sapiens	9-12
20951799-5	2010	Here, we show that the crosstalk between EGCG and Trx/TrxR occurred in a redox-dependent manner, and EGCG induced inactivation of Trx/TrxR in parallel with increased ROS levels in HeLa cells.	ros	166-169	thioredoxin	Homo sapiens	50-53
20951799-5	2010	Here, we show that the crosstalk between EGCG and Trx/TrxR occurred in a redox-dependent manner, and EGCG induced inactivation of Trx/TrxR in parallel with increased ROS levels in HeLa cells.	ros	166-169	peroxiredoxin 5	Homo sapiens	54-58
20951799-5	2010	Here, we show that the crosstalk between EGCG and Trx/TrxR occurred in a redox-dependent manner, and EGCG induced inactivation of Trx/TrxR in parallel with increased ROS levels in HeLa cells.	ros	166-169	thioredoxin	Homo sapiens	54-57
20951799-5	2010	Here, we show that the crosstalk between EGCG and Trx/TrxR occurred in a redox-dependent manner, and EGCG induced inactivation of Trx/TrxR in parallel with increased ROS levels in HeLa cells.	ros	166-169	peroxiredoxin 5	Homo sapiens	134-138
20888796-3	2010	Treatment of IL-32 increased ROS production and augmented lipopolysaccharide-induced increased production of nitric oxide as well as the expression of iNOS.	ros	29-32	interleukin 32	Homo sapiens	13-18
20802255-11	2010	CONCLUSIONS: Adiponectin prevents EPC senescence by inhibiting the ROS/p38 MAPK/p16(INK4A) signaling cascade.	ros	67-70	adiponectin, C1Q and collagen domain containing	Mus musculus	13-24
21351627-8	2010	The cellular ROS level in the three kinds of cells were increased in a concentration dependent way after treated with HQ and it was more stronger in pol beta -/- cell than those in other two kinds of cells (P &lt; 0.05).	ros	13-16	polymerase (DNA directed), beta	Mus musculus	149-157
21351627-12	2010	CONCLUSION: Cellular ROS generation could be effectively induced by HQ, leading to DNA and chromosomal damage, pol beta overexpression could help cells response to oxidative damage and protect cells from genotoxicity induced by HQ.	ros	21-24	polymerase (DNA directed), beta	Mus musculus	111-119
22396858-9	2010	On these grounds such theories as Hormesis and Target of rapamycin (mTOR) theories refute the role of ROS and oxidative stress in aging.	ros	102-105	mechanistic target of rapamycin kinase	Mus musculus	68-72
24793375-7	2014	Furthermore, free radical scavengers N-acetyl-L-cysteine (NAC) pretreatment test testified that chimaphilin could increase the generation of ROS, then induce cell apoptosis.	ros	141-144	X-linked Kx blood group	Homo sapiens	58-61
24880019-6	2014	Moreover, CCl4-induced profound elevation of ROS and oxidative stress, as evidenced by the increase of lipid peroxidation level and the depletion of the total antioxidant capacity (TAC) level in the kidney, was suppressed by treatment with UA.	ros	45-48	chemokine (C-C motif) ligand 4	Mus musculus	10-14
24704296-4	2014	Cytotoxicity, CD30 down-modulation and CD30 shedding by DHMEQ were prevented by ROS scavenger NAC.	ros	80-83	TNF receptor superfamily member 8	Homo sapiens	14-18
24704296-4	2014	Cytotoxicity, CD30 down-modulation and CD30 shedding by DHMEQ were prevented by ROS scavenger NAC.	ros	80-83	TNF receptor superfamily member 8	Homo sapiens	39-43
24909514-0	2014	RIP3 overexpression sensitizes human breast cancer cells to parthenolide in vitro via intracellular ROS accumulation.	ros	100-103	receptor interacting serine/threonine kinase 3	Homo sapiens	0-4
24909514-9	2014	Moreover, overexpression of RIP3 significantly increased parthenolide-induced apoptosis and ROS accumulation in MCF-7 and MDA-MB-231 cells.	ros	92-95	receptor interacting serine/threonine kinase 3	Homo sapiens	28-32
24909514-11	2014	CONCLUSION: Overexpression of RIP3 sensitizes MCF-7 and MDA-MB-231 breast cancer cells to parthenolide in vitro via intracellular ROS accumulation.	ros	130-133	receptor interacting serine/threonine kinase 3	Homo sapiens	30-34
24602596-6	2014	An overflow of mitochondrial ROS decreases mitochondrial biogenesis through a decrease in the transcriptional co-activator Hap4p, which can be assimilated to mitochondria quality control.	ros	29-32	transcription factor HAP4	Saccharomyces cerevisiae S288C	123-128
24937426-5	2014	Enhanced senescence coincided with increased ROS, elevated p16(INK4a) expression, and hypophosphorylated Rb and was inhibited by treatment with a ROS scavenger or inhibition of p38/MAPK and JNK.	ros	146-149	mitogen-activated protein kinase 8	Mus musculus	190-193
24513179-4	2014	Increased generation of hypoxic ROS is responsible for HIF-1alpha stabilization and GLI1 upregulation.	ros	32-35	GLI family zinc finger 1	Homo sapiens	84-88
24872551-9	2014	OGD/reoxygenation-induced elevation of ROS, reduction of GSH, dysfunction of mitochondria, and activation of caspase-3 were rescued by overexpression of TIGAR or supplementation of NADPH, while knockdown of TIGAR aggravated these changes.	ros	39-42	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	153-158
22396858-11	2010	In spite of apparent contradictions the Hormesis or TOR theories are also describing processes of aging development regulated by ROS signaling.	ros	129-132	tortured	Mus musculus	52-55
24607510-9	2014	Rhamnetin also enhanced the expression of catalase and Mn-SOD, thereby inhibiting production of intracellular ROS.	ros	110-113	superoxide dismutase 2	Rattus norvegicus	55-61
19954954-3	2010	Here, we studied whether neurons were an important target of blueberry extract and whether the mechanism involved altered ROS signaling through MAP kinase and cyclic-AMP response element binding protein (CREB), pathways known to be activated in response to amyloid-beta (Abeta).	ros	122-125	cAMP responsive element binding protein 1	Rattus norvegicus	159-202
24810048-0	2014	Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.	ros	18-21	mitogen-activated protein kinase 8	Mus musculus	68-71
24810048-5	2014	Increased intracellular ROS induced (i) Yes-associated protein 1 (YAP1) expression independent of the canonical Hippo pathway as well as (ii) ATM and JNK activation.	ros	24-27	mitogen-activated protein kinase 8	Mus musculus	150-153
24810048-11	2014	Our study highlights the coordinated control of glioma cell proliferation and metabolism by ROS through (i) ATM-YAP1-driven apoptotic pathway and (ii) JNK-regulated metabolic adaptation.	ros	92-95	mitogen-activated protein kinase 8	Mus musculus	151-154
19954954-3	2010	Here, we studied whether neurons were an important target of blueberry extract and whether the mechanism involved altered ROS signaling through MAP kinase and cyclic-AMP response element binding protein (CREB), pathways known to be activated in response to amyloid-beta (Abeta).	ros	122-125	cAMP responsive element binding protein 1	Rattus norvegicus	204-208
20581092-6	2010	Both adiponectin and anti-LOX-1 treatment reduced ROS production and aortic ox-LDL uptake.	ros	50-53	adiponectin, C1Q and collagen domain containing	Mus musculus	5-16
24695641-5	2014	Increasing medium concentrations of soluble Klotho and FGF23 both stimulated aorta contractions and increased ROS production in HVSMC.	ros	110-113	klotho	Homo sapiens	44-50
24695641-5	2014	Increasing medium concentrations of soluble Klotho and FGF23 both stimulated aorta contractions and increased ROS production in HVSMC.	ros	110-113	fibroblast growth factor 23	Homo sapiens	55-60
24695641-7	2014	Thus Klotho increased both ROS production in HVSMC and NO production in endothelium.	ros	27-30	klotho	Homo sapiens	5-11
24695641-8	2014	FGF23 induced contraction in phosphate preconstricted vessels and increased ROS production.	ros	76-79	fibroblast growth factor 23	Homo sapiens	0-5
20581092-6	2010	Both adiponectin and anti-LOX-1 treatment reduced ROS production and aortic ox-LDL uptake.	ros	50-53	oxidized low density lipoprotein (lectin-like) receptor 1	Mus musculus	21-31
24518283-6	2014	The secretion of TNF-alpha (from RAW 264.7), OPG and RANKL protein (from ROS 17/2.8) was analyzed by ELISA.	ros	73-76	TNF superfamily member 11	Homo sapiens	53-58
20435158-9	2010	The induction of IDO by IFN-gamma in HLE-B3 cells caused increases in intracellular ROS, cytosolic cytochrome c and caspase-3 activity, along with a decrease in protein-free thiol content.	ros	84-87	indoleamine 2,3-dioxygenase 1	Homo sapiens	17-20
24518283-7	2014	The OPG and RANKL mRNA from ROS 17/2.8 was detected by RT-PCR.	ros	28-31	TNF superfamily member 11	Homo sapiens	12-17
24681637-11	2014	Conversely, downregulation of Keap1 decreased autophagy levels, increased Nrf2 activation, upregulated cytoprotective antioxidant gene expression, and caused accumulation of p62, suggesting a feedback loop between ROS-regulated Keap1-Nrf2 and Atg7-regulated autophagy.	ros	214-217	nucleoporin 62	Homo sapiens	174-177
20139070-1	2010	Sirt1, a NAD-dependent protein deacetylase, is reported to regulate intracellular metabolism and attenuate reactive oxidative species (ROS)-induced apoptosis leading to longevity and acute stress resistance.	ros	135-138	sirtuin 1	Mus musculus	0-5
24558397-9	2014	Kallistatin scavenged H2O2-induced ROS in the LX-2 cells, and suppressed the activation of primary HSC.	ros	35-38	serpin family A member 4	Homo sapiens	0-11
20230789-0	2010	Phosphorylation of serine282 in NADPH oxidase activator 1 by Erk desensitizes EGF-induced ROS generation.	ros	90-93	epidermal growth factor	Mus musculus	78-81
20206201-5	2010	It is becoming apparent that hypoxia causes the progressive elevation in mitochondrial ROS production (chronic ROS) which over time leads to stabilization of cells via increased HIF-2alpha expression, enabling cells to survive with sustained levels of elevated ROS.	ros	87-90	endothelial PAS domain protein 1	Homo sapiens	178-188
20206201-5	2010	It is becoming apparent that hypoxia causes the progressive elevation in mitochondrial ROS production (chronic ROS) which over time leads to stabilization of cells via increased HIF-2alpha expression, enabling cells to survive with sustained levels of elevated ROS.	ros	111-114	endothelial PAS domain protein 1	Homo sapiens	178-188
20206201-5	2010	It is becoming apparent that hypoxia causes the progressive elevation in mitochondrial ROS production (chronic ROS) which over time leads to stabilization of cells via increased HIF-2alpha expression, enabling cells to survive with sustained levels of elevated ROS.	ros	111-114	endothelial PAS domain protein 1	Homo sapiens	178-188
20206201-6	2010	In cells under hypoxia and/or low glucose, DNA mismatch repair processes are repressed by HIF-2alpha and they continually accumulate mitochondrial ROS-induced oxidative DNA damage and increasing numbers of mutations driving the malignant transformation process.	ros	147-150	endothelial PAS domain protein 1	Homo sapiens	90-100
19892012-11	2010	These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.	ros	43-46	toll like receptor 4	Homo sapiens	83-87
19892012-11	2010	These results demonstrate that CSE-induced ROS generation was mediated through the TLR4/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiated the activation of MAPKs and NF-kappaB, and ultimately induced COX-2/PGE(2)/IL-6-dependent airway inflammation.	ros	43-46	TNF receptor associated factor 6	Homo sapiens	94-99
20521390-3	2010	In humans several diseases including those connected with the heart, lung, and the eye are associated with the accumulation of reactive oxygen and nitrogen species (ROS/RNS).	ros	165-168	FAM20C golgi associated secretory pathway kinase	Homo sapiens	169-172
20652061-4	2010	Taken together, these results suggest that overexpression of HIF-2alpha in CCRCC 786-0 tumors regulated growth both by maintaining a low level of glycolysis and by allowing more mitochondrial metabolism and tolerance to ROS induced DNA damage.	ros	220-223	endothelial PAS domain protein 1	Homo sapiens	61-71
19887113-6	2010	Besides nitrite, PAR-2 activation increased production of a variety of inflammatory mediators such as ROS and pro-inflammatory cytokines including TNF-alpha and IL-1beta.	ros	102-105	F2R like trypsin receptor 1	Rattus norvegicus	17-22
20596957-0	2010	Advanced oxidation protein products decrease expression of nephrin and podocin in podocytes via ROS-dependent activation of p38 MAPK.	ros	96-99	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	59-66
20193368-7	2009	Knock down of the p47(phox) subunit for NADPH oxidase by siRNA abolished the production of ROS.	ros	91-94	pleckstrin	Homo sapiens	18-21
20193368-7	2009	Knock down of the p47(phox) subunit for NADPH oxidase by siRNA abolished the production of ROS.	ros	91-94	pleckstrin	Homo sapiens	22-26
20193368-10	2009	CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase.	ros	12-15	heme oxygenase 1	Homo sapiens	37-41
20193368-10	2009	CONCLUSION: ROS only partly mediated HO-1; expression in the TNF-alpha-stimulated HUVEC; alpha-ZAL has a potent inhibitory effect on the HO-1 expression and cytosolic free calcium level in the TNF-alpha-stimulated HUVEC, mainly through the inhibition of ROS generation derived from NADPH oxidase.	ros	12-15	heme oxygenase 1	Homo sapiens	137-141
19703605-2	2009	We found that CLIC1 was expressed in mouse (MC3T3-E1), rat (ROS 17/2.8 and UMR-106) or human (MG63 and SaOS2) osteoblastic cell lines as well as primary culture of mouse calvarial cells by RT-PCR or Western blot analysis.	ros	60-63	chloride intracellular channel 1	Mus musculus	14-19
18544047-6	2009	Through suppressing the expression of another ERRalpha target gene pyruvate dehydrogenase kinase 2 (PDK2), we found that XCT-790 not only enhanced the conversion of pyruvate to acetyl-CoA and hyper-activated the tricarboxylic acid (TCA) cycle, but also led to higher levels of mitochondrial membrane potential and reactive oxidant species (ROS) production.	ros	340-343	solute carrier family 7 member 11	Homo sapiens	121-124
19615399-3	2009	OBJECTIVE: We studied the role of protein kinase A (PKA), protein kinase B (Akt/PKB) and p38 mitogen-activated protein kinase (p38 MAPK) signaling pathways in ROS produced by neutrophils induced by pro-interferon-gamma (IFN-gamma) or anti-inflammatory interleukin 10 (IL-10) cytokines age-related.	ros	159-162	protein tyrosine kinase 2 beta	Homo sapiens	58-74
19292616-6	2009	siRNA VDR silencing prevented 1,25D stimulation of ATP exocytosis in ROS 17/2.8 and SAOS-2 cells.	ros	69-72	vitamin D receptor	Rattus norvegicus	6-9
24410747-14	2014	In contrast, p5cdh infected plants displayed increased ROS burst and earlier initiation of HR cell death.	ros	55-58	aldehyde dehydrogenase 12A1	Arabidopsis thaliana	13-18
24259511-4	2014	Exogenous TGF-beta1-induced podocyte apoptosis through caspase-3 activation, which was related to elevated ROS levels generated by selective upregulation of NADPH oxidase 4 (Nox4).	ros	107-110	caspase 3	Mus musculus	55-64
25093162-10	2014	Taken together, these data not only provide the first in vivo evidence for a role of RIP3 in TNF-alpha-induced toxicity of hippocampal neurons, but also demonstrate that TNF-alpha promotes CYLD-RIP1-RIP3-MLKL-mediated necroptosis of hippocampal neurons largely bypassing ROS accumulation and calcium influx.	ros	271-274	mixed lineage kinase domain-like	Mus musculus	204-208
24987494-7	2014	To further elucidate the roles of Mfn2 and O-GlcNAcylation, we employed ARPE-19 cells and found that ATP production, oxygen consumption, and mitochondrial membrane potential were reduced and ROS level was increased by Mfn2 knockdown, while treating with PUGNAc or UDP-GlcNAc heightened oxygen consumption and reduced ROS.	ros	191-194	mitofusin 2	Homo sapiens	218-222
24268699-6	2013	Moreover, we found that ROS-induced autophagy acts as a negative feedback regulator of JNK activity by dissociating Atg9/mAtg9 from dTRAF2/TRAF6 in Drosophila and mammalian cells, respectively.	ros	24-27	autophagy related 9A	Mus musculus	121-126
23911537-3	2013	Increased ROS induces rpS3 accumulation in the mitochondria for DNA repair while significantly decreasing the cellular protein synthesis.	ros	10-13	ribosomal protein S3	Homo sapiens	22-26
23911537-6	2013	Furthermore, cellular ROS was decreased and mtDNA damage was rescued when levels of rpS3 were increased in the mitochondria.	ros	22-25	ribosomal protein S3	Homo sapiens	84-88
23911537-7	2013	Therefore, we concluded that when mitochondrial DNA damages accumulate due to increased levels of ROS, rpS3 accumulates in the mitochondria to repair damaged DNA due to the decreased interaction between rpS3 and HSP90 in the cytosol.	ros	98-101	ribosomal protein S3	Homo sapiens	103-107
24121479-0	2013	A novel antitumor piperazine alkyl compound causes apoptosis by inducing RhoB expression via ROS-mediated c-Abl/p38 MAPK signaling.	ros	93-96	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	106-111
24121479-5	2013	KR28 increased ROS production, leading to nuclear c-Abl expression, which in turn activated p38 mitogen-activated protein kinase (MAPK) to enhance the expression of RhoB, an apoptosis inducer.	ros	15-18	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	50-55
24121479-8	2013	CONCLUSION: The antitumor agent KR28 induces apoptosis of PC-3 cells by ROS-mediated RhoB expression via c-Abl upregulation and activation of p38 MAPK/ATF-2.	ros	72-75	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	105-110
24121479-8	2013	CONCLUSION: The antitumor agent KR28 induces apoptosis of PC-3 cells by ROS-mediated RhoB expression via c-Abl upregulation and activation of p38 MAPK/ATF-2.	ros	72-75	activating transcription factor 2	Homo sapiens	151-156
24265619-4	2013	Transgenic activation of beta2-adrenoceptor leads to elevation of NADPH oxidase activity, with greater ROS production and p38MAPK phosphorylation.	ros	103-106	adrenoceptor beta 2	Homo sapiens	25-43
24265619-6	2013	Chronic beta2-adrenoceptor activation is associated with greater cardiac dilatation and dysfunction, augmented pro-inflammatory and profibrotic signaling, while antioxidant treatment protected hearts against these abnormalities, indicating ROS production to be central to the detrimental signaling of beta2-adrenoceptors.	ros	240-243	adrenoceptor beta 2	Homo sapiens	8-26
2477233-2	1989	ROS cells treated with 10 nM [Nle8,Nle18,Tyr34] bovine (b) PTH-(1-34) amide (NlePTH) for 3 days showed loss of specific PTH binding and PTH-stimulated cAMP accumulation to 10% of that in vehicle-treated control cells.	ros	0-3	parathyroid hormone	Bos taurus	59-62
2477233-2	1989	ROS cells treated with 10 nM [Nle8,Nle18,Tyr34] bovine (b) PTH-(1-34) amide (NlePTH) for 3 days showed loss of specific PTH binding and PTH-stimulated cAMP accumulation to 10% of that in vehicle-treated control cells.	ros	0-3	parathyroid hormone	Bos taurus	80-83
2477233-2	1989	ROS cells treated with 10 nM [Nle8,Nle18,Tyr34] bovine (b) PTH-(1-34) amide (NlePTH) for 3 days showed loss of specific PTH binding and PTH-stimulated cAMP accumulation to 10% of that in vehicle-treated control cells.	ros	0-3	parathyroid hormone	Bos taurus	80-83
2477233-10	1989	In conclusion, agonist-induced PTH receptor down-regulation in ROS 17/2.8 cells is cAMP independent and can be reversed by PT treatment.	ros	63-66	parathyroid hormone	Bos taurus	31-34
2537172-11	1989	Pretreatment of ROS cells with PTH resulted in a transient decrease in the phosphorylation of these cytosolic proteins by PKC.	ros	16-19	protein kinase C, gamma	Rattus norvegicus	122-125
2537172-13	1989	These data suggest a potential role for PKC in the mechanism of action of PTH in ROS cells.	ros	81-84	protein kinase C, gamma	Rattus norvegicus	40-43
2537630-2	1989	In vitro studies revealed that all four analogues antagonized PTHrP-stimulated cyclic AMP production in rat osteosarcoma cells (ROS 17/2.8), and that PTHrP(7-34)NH2 and PTHrP(10-34)NH2 had potent antagonistic activity.	ros	128-131	parathyroid hormone-like hormone	Rattus norvegicus	62-67
2643512-8	1989	Mitogenic activity induced by both PTH- and LPS-treated ROS cell CM was completely inhibited by anti-GM CSF antibody, whereas there was no reduction in activity in the presence of antibodies to IL-2 or IL-4.	ros	56-59	colony stimulating factor 2	Rattus norvegicus	101-107
2464756-2	1989	In this study we examined the effect of cAMP, alone and in combination with 1,25-(OH)2D3, on the regulation of BGP mRNA levels in ROS 17/2 rat osteosarcoma cells.	ros	130-133	CEA cell adhesion molecule 1	Rattus norvegicus	111-114
3039503-1	1987	A retrovirus containing part of the human insulin receptor (hIR) gene was constructed by replacing ros sequences in the avian sarcoma virus UR2 with hIR cDNA sequences coding for 46 amino acids of the extracellular domain and the entire transmembrane and cytoplasmic domains of the beta subunit of hIR.	ros	99-102	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	60-63
3472760-9	1986	Finally, by substitution of a homologous TPK for that of hIR, we find that although such a hybrid is capable of insulin-dependent transmembrane signaling (phosphorylation of the hybrid beta-subunit on tyrosine residues), the hybrid IR.ros molecule does not function as an IR in such cells: It mediates neither short-term (uptake of 2-deoxyglucose) nor long-term (incorporation of [3H]thymidine) effects of insulin (L. Ellis et al., in prep.).	ros	203-206	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	57-60
3472760-9	1986	Finally, by substitution of a homologous TPK for that of hIR, we find that although such a hybrid is capable of insulin-dependent transmembrane signaling (phosphorylation of the hybrid beta-subunit on tyrosine residues), the hybrid IR.ros molecule does not function as an IR in such cells: It mediates neither short-term (uptake of 2-deoxyglucose) nor long-term (incorporation of [3H]thymidine) effects of insulin (L. Ellis et al., in prep.).	ros	203-206	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	58-60
33677277-7	2021	The damaged cell membrane, protein leakage, and increased ROS level contribute to the antibacterial activity of PAM-GO-Ag.	ros	58-61	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	112-115
19649246-1	2009	BACKGROUND: Neutrophils play a major role in inflammation by releasing large amounts of ROS produced by NADPH-oxidase and myeloperoxidase (MPO).	ros	88-91	myeloperoxidase	Rattus norvegicus	122-137
19649246-1	2009	BACKGROUND: Neutrophils play a major role in inflammation by releasing large amounts of ROS produced by NADPH-oxidase and myeloperoxidase (MPO).	ros	88-91	myeloperoxidase	Rattus norvegicus	139-142
19546506-8	2009	Real-time PCR analysis of enzymatic scavengers expressed in the mouse epididymis indicated that the cauda epididymidis epithelium of Gpx5-null male mice mounted an antioxidant response to cope with an excess of ROS.	ros	211-214	glutathione peroxidase 5	Mus musculus	133-137
33713737-6	2021	Combination of ASCT2 inhibitor V9302 and proteasome inhibitor carfilzomib upregulates the intracellular levels of ROS and oxidative stress markers and triggers catastrophic UPR as shown by upregulated spliced Xbp1 mRNA, ATF3 and CHOP levels.	ros	114-117	solute carrier family 1 member 5	Homo sapiens	15-20
33432550-5	2021	We also found that ROS-activated CLIC1-induced oxidative stress in HUVECs.	ros	19-22	chloride intracellular channel 1	Homo sapiens	33-38
19249354-5	2009	MEK/ERK involvement downstream of ROS generation was critical for PAI-1, but not CTGF, expression following cytoskeletal perturbation suggesting bifurcation of signaling pathways downstream of EGFR activation.	ros	34-37	serpin family E member 1	Homo sapiens	66-71
33432550-8	2021	And inhibition of CLIC1 decreases oxidative stress injury by downregulating the levels of ROS, MDA, and the expression of EC effectors (ICAM1 and VCAM1) protein expression and promotes the activity of superoxide dismutase (SOD).	ros	90-93	chloride intracellular channel 1	Homo sapiens	18-23
19180563-0	2009	ROS-mediated p38alpha MAPK activation and ERK inactivation responsible for upregulation of Fas and FasL and autocrine Fas-mediated cell death in Taiwan cobra phospholipase A(2)-treated U937 cells.	ros	0-3	Fas ligand	Homo sapiens	99-103
33831169-9	2021	We also observed that excess ROS accumulated in myb21 stamen, and that treatment with dipenyleneiodonium chloride (DPI, a ROS inhibitor) can partly rescue the reduced-fertility of a myb21 mutant.	ros	122-125	myb domain protein 21	Arabidopsis thaliana	182-187
19180563-5	2009	Abolition of PLA(2)-induced ROS generation abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored ERK activation and viability of PLA(2)-treated cells.	ros	28-31	Fas ligand	Homo sapiens	101-105
19180563-11	2009	Taken together, our results indicate that Fas/FasL upregulation in PLA(2)-treated U937 cells is elicited by ROS-mediated p38alpha MAPK activation and ERK inactivation, and suggest that autocrine Fas/FasL apoptotic mechanism is involved in PLA(2)-induced cell death.	ros	108-111	Fas ligand	Homo sapiens	46-50
19180563-11	2009	Taken together, our results indicate that Fas/FasL upregulation in PLA(2)-treated U937 cells is elicited by ROS-mediated p38alpha MAPK activation and ERK inactivation, and suggest that autocrine Fas/FasL apoptotic mechanism is involved in PLA(2)-induced cell death.	ros	108-111	Fas ligand	Homo sapiens	199-203
34015450-0	2021	IL-22 ameliorated cardiomyocyte apoptosis in cardiac ischemia/reperfusion injury by blocking mitochondrial membrane potential decrease, inhibiting ROS and cytochrome C.	ros	147-150	interleukin 22	Homo sapiens	0-5
19264123-7	2009	At last, it was shown that Abeta antibody and antiserum prevented increase of ROS and reduction of mitochondrial membrane potential in N2a/Swe.DeltaE9 cells but not in N2a/Swe.D385A cells, which indicated that reduced formation of Abeta was the reason for reduction of ROS formation and increase of mitochondrial membrane potential when PS-1 activity was impaired in N2a/Swe.D385A cells.	ros	78-81	amyloid beta (A4) precursor protein	Mus musculus	27-32
34015450-6	2021	Our results showed that, in vitro, IL-22 prevented cardiomyocyte apoptosis induced by Angiotensin II via enhancing the activity of SOD, blocking the decrease of mitochondrial membrane potential, inhibiting ROS production and release of cytochrome C.	ros	206-209	interleukin 22	Homo sapiens	35-40
34045966-4	2021	Meanwhile, CD13 can activate NRF1 and up-regulate ROS scavenging genes transcription, such as SOD1, GPX1, GPX2 and GPX3, leading to down-regulation of intracellular ROS level and reducing the sensitivity of cells to chemotherapy agent.	ros	50-53	glutathione peroxidase 1	Homo sapiens	100-104
33956815-10	2021	Moreover, findings of this research provide persuasive support for the notion that DNC could reduce the LLLT-induced enhancement in intracellular ROS in mouse embryonic fibroblasts.	ros	146-149	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	Mus musculus	83-86
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	Rac family small GTPase 1	Homo sapiens	149-153
19264123-7	2009	At last, it was shown that Abeta antibody and antiserum prevented increase of ROS and reduction of mitochondrial membrane potential in N2a/Swe.DeltaE9 cells but not in N2a/Swe.D385A cells, which indicated that reduced formation of Abeta was the reason for reduction of ROS formation and increase of mitochondrial membrane potential when PS-1 activity was impaired in N2a/Swe.D385A cells.	ros	269-272	amyloid beta (A4) precursor protein	Mus musculus	27-32
19334530-6	2009	Furthermore, purified recombinant UCN II protein specifically binds to CRF receptor 2 in rat ROS 17/2.8 and GH3 cells by flow-cytometry analysis.	ros	93-96	urocortin 2	Rattus norvegicus	34-40
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	Rac family small GTPase 1	Homo sapiens	207-211
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	Kruppel like factor 4	Homo sapiens	292-313
33759281-10	2021	Compared to the known actin organization activities of the Abi1 gene, we discovered a novel action of Abi1-Deltae10, whereby Abi1-Deltae10 activates Rac1 independent of upstream stimulation and triggers the Rac1-NOX1-ROS pathway, which results in increased expression of transcription factor Kruppel-like factor 4 (KLF4).	ros	217-220	Kruppel like factor 4	Homo sapiens	315-319
23589029-3	2013	The mechanism of Pyr2 enV(IV) effect relied on apoptosis induction; this was triggered by ROS increase, followed by mitochondrial membrane depolarization.	ros	90-93	endogenous retrovirus group K member 20	Homo sapiens	22-25
23589029-5	2013	These results disclose the pro-apoptotic activity of Pyr2 enV(IV) and its mechanism, relying on intracellular ROS increase.	ros	110-113	endogenous retrovirus group K member 20	Homo sapiens	58-61
24030954-7	2013	Further cellular analysis showed that T-2 toxin was able to induce the ROS accumulation and could lead to an increase in mitochondrial mass and adenosine 5"-triphosphate content, which indicated that oxidative stress and mitochondrial enhancement occurred in T-2 toxin-treated cells.	ros	71-74	solute carrier family 25 member 5	Homo sapiens	38-41
19137062-5	2009	Inhibition of beta-catenin phosphorylation by LiCl reversed ROS generation and cell death in PS deficient cells.	ros	60-63	catenin beta 1	Homo sapiens	14-26
19137062-7	2009	These results indicate that aberrant accumulation of phospho-beta-catenin underlies ROS-mediated cell death in the absence of PS.	ros	84-87	catenin beta 1	Homo sapiens	61-73
33731308-7	2021	Ectopic expression of PERP-428G, but not PERP-428C, protects lung cancer cells against ROS-induced DNA damage.	ros	87-90	p53 apoptosis effector related to PMP22	Homo sapiens	22-26
19007111-3	2008	The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21.	ros	112-115	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	232-237
23990467-0	2013	Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation.	ros	113-116	STEAP4 metalloreductase	Homo sapiens	0-6
19007111-3	2008	The metabolically released formaldehyde from the prodrugs was the dominant factor affecting cell viability by a ROS-dependent mechanism and was responsible for rapid phosphorylation of H2AX, suppression of the cell survival protein c-myc, and transient elevation in the expression of p21.	ros	112-115	H3 histone pseudogene 16	Homo sapiens	284-287
23774252-0	2013	NADPH oxidase/ROS-dependent PYK2 activation is involved in TNF-alpha-induced matrix metalloproteinase-9 expression in rat heart-derived H9c2 cells.	ros	14-17	matrix metallopeptidase 9	Rattus norvegicus	77-103
33635525-6	2021	Inhibiting HMGB1 by GL improved AMPK activation, decreased mitochondrial ROS levels, increased mitochondrial membrane potential, normalized mitochondrial fission/fusion balance, and consequently reduced apoptosis of BMSCs under HG condition.	ros	73-76	high mobility group box 1	Rattus norvegicus	11-16
18617666-2	2008	After cerebral ischemia, oxidative DNA lesions accumulate in neurons because of increased attacks by ROS and diminished DNA repair activity, leading to PARP-1 activation, NAD(+) depletion, and cell death.	ros	101-104	poly (ADP-ribose) polymerase 1	Rattus norvegicus	152-158
33159803-5	2021	Coincubation with the PAR4-AP/LPS enhanced NO and ROS production and iNOS expression; decreased IL-10, but not TNF-alpha, in the culture supernatant; and increased translocation of the p65 subunit of the proinflammatory gene transcription factor NF-kappa-B.	ros	50-53	F2R like thrombin or trypsin receptor 3	Homo sapiens	22-26
23643711-4	2013	Our hypothesis is that the low mitochondrial oxygen consumption leads to elevated ROS production by a mechanism associated with reduced PGC1alpha transcription and low content of phosphorylated CREB.	ros	82-85	cAMP responsive element binding protein 1	Homo sapiens	194-198
23816368-6	2013	RESULTS: Curcumin significantly attenuated Abeta-induced cell death, loss of synaptophysin, and ROS generation.	ros	96-99	amyloid beta precursor protein	Rattus norvegicus	43-48
18417276-3	2008	Engagement of B7-H4 initially increased intracellular level of ROS, which then induced the expression of FasL.	ros	63-66	Fas ligand	Homo sapiens	105-109
24086340-6	2013	In oral carcinoma cells, p62/SQSTM1 knockdown did not affect the Nrf2-Keap1 pathway but did significantly reduce GSH content with subsequent ROS accumulation, and caused cell growth inhibition in the irradiated condition.	ros	141-144	sequestosome 1	Homo sapiens	25-28
24086340-6	2013	In oral carcinoma cells, p62/SQSTM1 knockdown did not affect the Nrf2-Keap1 pathway but did significantly reduce GSH content with subsequent ROS accumulation, and caused cell growth inhibition in the irradiated condition.	ros	141-144	sequestosome 1	Homo sapiens	29-35
24042587-9	2013	Transfection of ROS 17/2.8 cells with Runx2, Dlx5 or c-Src overexpression plasmid increased the luciferase activities of the constructs, pLUC3 (-116 to +60), pLUC4 (-425 to +60) and pLUC5 (-801 to +60).	ros	16-19	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	53-58
33914383-18	2021	Knockdown of NEAT1 or Drp1 inhibited excessive ROS production and LDH release, increased cell viability, MMP, SOD activity and enhanced mitophagy in HG-challenged HK-2 cells.	ros	47-50	nuclear paraspeckle assembly transcript 1	Homo sapiens	13-18
33914383-18	2021	Knockdown of NEAT1 or Drp1 inhibited excessive ROS production and LDH release, increased cell viability, MMP, SOD activity and enhanced mitophagy in HG-challenged HK-2 cells.	ros	47-50	utrophin	Homo sapiens	22-26
33924902-1	2021	The current results indicated the possible protective actions of 18 kDa mitochondrial translocator protein (TSPO) deletion on TRPM2 stimulation, mitochondrial free ROS (Mito-fROS) and apoptotic harmful actions in the cells of adult retinal pigment epithelial19 (ARPE19).	ros	164-167	translocator protein	Homo sapiens	86-106
33924902-1	2021	The current results indicated the possible protective actions of 18 kDa mitochondrial translocator protein (TSPO) deletion on TRPM2 stimulation, mitochondrial free ROS (Mito-fROS) and apoptotic harmful actions in the cells of adult retinal pigment epithelial19 (ARPE19).	ros	164-167	translocator protein	Homo sapiens	108-112
23441883-5	2013	Stimulation of bEND3 with DKA plasma caused cellular activation (increased ROS and activation of NF-kappaBeta), upregulation of a proadhesive phenotype (E-selectin, ICAM-1, and VCAM-1), and increased leukocyte-bEND3 interaction (leukocyte rolling/adhesion).	ros	75-78	BEN domain containing 3	Mus musculus	15-20
18619952-8	2008	This indicates that p53 expression is linked to ROS generation in mice testes.	ros	48-51	transformation related protein 53, pseudogene	Mus musculus	20-23
23895055-6	2013	Besides, it directly inhibited VEGFR2 tyrosine kinase activity and its downstream signaling pathways including Akt, Erk and ROS in endothelial cells.	ros	124-127	kinase insert domain receptor	Homo sapiens	31-37
18289679-11	2008	CD44 mediated effect of antigen on phosphorylation of ERK, p38MAPK, ROS production, secretion of beta-hexosaminidase, and histamine release.	ros	68-71	CD44 molecule (Indian blood group)	Rattus norvegicus	0-4
33904969-12	2021	GLA induces TSCC cells apoptosis, autophagy and ROS production in a time- and concentration-dependent manner.	ros	48-51	galactosidase alpha	Homo sapiens	0-3
18281070-10	2008	These results support a role for ROS in c-Myb and Pim-1 alterations after in utero benzene exposure.	ros	33-36	myeloblastosis oncogene	Mus musculus	40-45
33904969-13	2021	In addition, GLA inhibits the viability of TSCC cells by inducing intracellular ROS production.	ros	80-83	galactosidase alpha	Homo sapiens	13-16
33904969-14	2021	Finally, GLA triggers ROS-dependent apoptosis and autophagy in TSCC cells.	ros	22-25	galactosidase alpha	Homo sapiens	9-12
33904969-15	2021	CONCLUSION: Our results consistently suggested that GLA can induce apoptosis and autophagy in TSCC cells by generating ROS.	ros	119-122	galactosidase alpha	Homo sapiens	52-55
33981228-8	2021	NAC, a ROS scavenger, rescued ROS over-accumulation and proliferation inhibition of galangin.	ros	7-10	X-linked Kx blood group	Homo sapiens	0-3
33981228-8	2021	NAC, a ROS scavenger, rescued ROS over-accumulation and proliferation inhibition of galangin.	ros	30-33	X-linked Kx blood group	Homo sapiens	0-3
18281070-10	2008	These results support a role for ROS in c-Myb and Pim-1 alterations after in utero benzene exposure.	ros	33-36	proviral integration site 1	Mus musculus	50-55
18431490-15	2008	We propose that ATM-dependent mitochondrial biogenesis may play a role in DNA damage response and ROS regulation, and that defect in ATM-dependent mitochondrial biogenesis could contribute to the manifestations of A-T disease.	ros	98-101	ATM serine/threonine kinase	Homo sapiens	16-19
33879840-6	2021	TMZ treatment induced intracellular ROS accumulation in U87 and U251 cells via enhancing mitochondrial superoxide, which not only contributed to DNA DSBs and exacerbated mitochondrial dysfunction, but also upregulated FOXO3a expression.	ros	36-39	small nucleolar RNA, C/D box 87	Homo sapiens	56-59
33496827-8	2021	FB1 induced accumulation of intracellular ROS (p <= 0.001) and LDH leakage (p <= 0.001).	ros	42-45	TCF3 fusion partner	Homo sapiens	0-3
33450497-5	2021	Further mechanistic studies revealed that the alleviation of pulmonary toxicity in 6"-DO-BLM Z by a slight change in the sugar moiety could attribute to the decrease of ROS production and thereby reduce the subsequent caspase-1 activity and resulting inflammatory response.	ros	169-172	BLM RecQ like helicase	Homo sapiens	89-92
33549731-0	2021	YM155 and BIRC5 downregulation induce genomic instability via autophagy-mediated ROS production and inhibition in DNA repair.	ros	81-84	baculoviral IAP repeat containing 5	Homo sapiens	10-15
33549731-6	2021	Using function-comparative analysis, we found in the current study that YM155 and BIRC5 siRNA both induced early "autophagy-dependent ROS production-mediated" DNA damage/strand breaks and concurrently downregulated the expression of RAD54L, RAD51, and MRE11, which are molecules known for their important roles in homologous recombination, in human cancer (MCF7, MDA-MB-231, and SK-BR-3) and mouse embryonic fibroblast (MEF) cells.	ros	134-137	baculoviral IAP repeat containing 5	Homo sapiens	82-87
33667838-12	2021	The inhibitory effects of BF-2 on ROS production were imaged by DCF (2",7"-dichlorofluorescein diacetate) probe.	ros	34-37	forkhead box D1	Mus musculus	26-30
33833855-5	2021	Decreasing cellular ROS levels using NAC reversed TSM- and TRAIL-induced apoptosis in 143B cells.	ros	20-23	X-linked Kx blood group	Homo sapiens	37-40
33531626-5	2021	Functionally, USP11 depletion contributes to the suppression of cell proliferation and induction of ferroptotic cell death due to ROS-mediated stress, which can be largely abrogated by overexpression of NRF2.	ros	130-133	ubiquitin specific peptidase 11	Homo sapiens	14-19
33452125-4	2021	HRG and C5a prolonged the survival time of isolated human neutrophils, in association with a reduction in the spontaneous production of extracellular ROS.	ros	150-153	histidine rich glycoprotein	Homo sapiens	0-3
33559506-6	2021	After overexpression of miR-26b-5p, cell proliferation ability was enhanced, apoptosis, ROS and inflammatory mediators were inhibited.	ros	88-91	microRNA 26b	Rattus norvegicus	24-31
33555225-0	2021	Glutathione peroxidase 2 (Gpx2) preserves mitochondrial function and decreases ROS levels in chronologically aged yeast.	ros	79-82	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	0-24
33555225-0	2021	Glutathione peroxidase 2 (Gpx2) preserves mitochondrial function and decreases ROS levels in chronologically aged yeast.	ros	79-82	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	26-30
33555225-10	2021	These results indicate that gpx2 is a late - acting antioxidant system that decreases mitochondrial ROS production and preserves ETC function, without being involved in the preservation of PUFA levels in mitochondria.	ros	100-103	glutathione peroxidase GPX2	Saccharomyces cerevisiae S288C	28-32
32094504-6	2021	Mechanistic experiments demonstrated that TRIM34 controlled TLR signaling-induced Nox/Duox-dependent ROS synthesis, thereby promoting the compound exocytosis of Muc2 by colonic GCs that were exposed to bacterial TLR ligands.	ros	101-104	tripartite motif-containing 34A	Mus musculus	42-48
32424294-7	2021	LCS-1-induced cell death is associated with: (1) increase in superoxide and ROS levels; (2) activation of caspases, and p53/p21 signaling; (3) decrease in MCL-1, BCLxL, CDC2, cyclin-B1, and c-Myc; (4) ER stress response; and (5) inhibition of proteasome function.	ros	76-79	LCS1	Homo sapiens	0-5
33458796-0	2021	Retraction Note to: Alpinumisoflavone rescues glucocorticoid-induced apoptosis of osteocytes via suppressing Nox2-dependent ROS generation.	ros	124-127	cytochrome b-245 beta chain	Homo sapiens	109-113
33429354-9	2021	This providing evidence that UA could be used to improve disorders in which ROS and RNS play important role, such as ischemic stroke and chronic neurodegeneration, as confirmed by BDNF results.	ros	76-79	brain derived neurotrophic factor	Homo sapiens	180-184
33467515-8	2021	Additionally, rPLP2 exposed barrier cells displayed features of cell death, including Annexin/PI positivity, depolarized the mitochondrial membrane potential, and ROS generation.	ros	163-166	proteolipid protein 2	Rattus norvegicus	14-19
33436696-6	2021	CMRP treatment resulted in phosphatidylserine externalization, increase in the levels of intracellular ROS, Ca2+, loss of mitochondrial membrane potential as well as fragmentation of genomic DNA.	ros	103-106	ATP binding cassette subfamily C member 2	Homo sapiens	0-4
33144123-7	2021	The p62-Keap1-Nrf2 positive feedback loop and the Nrf2 pathway are involved in eliminating the ROS and protein aggregates induced by AD.	ros	95-98	sequestosome 1	Homo sapiens	4-7
33035717-4	2021	DOX and Fc loaded in NLC/H(D + F + S) NPs effectively enhanced intracellular ROS level to activate ferroptosis pathway, the enhanced ROS also induced the apoptosis pathway and decreased MMP-9 expression to synergize with ferroptosis for tumor therapy.	ros	133-136	matrix metallopeptidase 9	Homo sapiens	186-191
33557613-11	2021	At cellular level, hyperglycemia-induced ROS increased the level of p21 in cerebral pericytes.	ros	41-44	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	68-71
33242606-8	2021	Moreover, measurements of foam cell accumulation and ROS production in sections of aortic roots showed those were reduced by puerarin but raised when additional treatment with PX-12 or Trx1 siRNA in apoE-/- mice, which demonstrates the lipid uptake reduction by puerarin requires Trx1 inhibition in vivo.	ros	53-56	thioredoxin 1	Mus musculus	185-189
33049495-7	2020	RESULTS: Juglanin reduces OSS-induced oxidative stress by reducing the production of ROS through downregulation of NOX-2 and rescuing OSS-induced reduced expression of eNOS.	ros	85-88	cytochrome b-245 beta chain	Homo sapiens	115-120
33077479-8	2020	RESULT: HRG maintained the round shape of differentiated neutrophil-like cells, decreased the time required by cells to pass through the microcapillaries, and inhibited ROS production, NETs formation, and the expression of activated CD11b on the cell surface.	ros	169-172	histidine rich glycoprotein	Homo sapiens	8-11
33097606-0	2020	Mitochondrial dysfunction triggers catabolic response in chondrocytes via ROS mediated activation of JNK/AP1 pathway.	ros	74-77	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-108
33246492-11	2020	Regarding oxidative stress, OA treatment prevented lipid peroxidation and superoxide anion accumulation in intestinal tissue, while inducing the expression of the ROS scavenger Sestrin-3.	ros	163-166	sestrin 3	Mus musculus	177-186
33262598-12	2020	Overexpression of SNHG7 or suppression of miR-9 decreased the relative activity of ROS and the MDA level as well as enhancing cell viability, and SNHG7 reduced apoptosis rate in OGD/R-induced PC12 cells (IS cells).	ros	83-86	small nucleolar RNA host gene 7	Mus musculus	18-23
23684856-5	2013	Furthermore, ING4 also induced mitochondrial dysfunction, such as mitophagy, collapse of mitochondrial membrane potential and the intracellular ROS, which indicated that mitochondria might be associated with the process of autophagic cell death of glioma cells.	ros	144-147	inhibitor of growth family member 4	Homo sapiens	13-17
23799024-4	2013	In the present study, we revealed that high glucose could induce GDF15 expression and secretion in cultured human umbilical vein endothelial cells in a ROS- and p53-dependent manner.	ros	152-155	growth differentiation factor 15	Homo sapiens	65-70
23333744-7	2013	The second phase operated under a prolonged HGF exposure, caused a suppression of the NADPH oxidase components, including NOX2, NOX4, p22 and p67, and was able to abrogate the TGFbeta-induced ROS production and improve cell viability.	ros	192-195	hepatocyte growth factor	Mus musculus	44-47
23297317-6	2013	The CD41(high) cells sustained intracellular ROS at the initial level for up to 72 h, but CD41(low) cells had reduced ROS by 48 h. The maximum suppressive effect on CD41 expression was observed when N-acetyl cysteine, which is known to act as a ROS scavenger, was administered 48 h after PMA stimulation.	ros	45-48	integrin subunit alpha 2b	Homo sapiens	4-8
23297317-6	2013	The CD41(high) cells sustained intracellular ROS at the initial level for up to 72 h, but CD41(low) cells had reduced ROS by 48 h. The maximum suppressive effect on CD41 expression was observed when N-acetyl cysteine, which is known to act as a ROS scavenger, was administered 48 h after PMA stimulation.	ros	118-121	integrin subunit alpha 2b	Homo sapiens	90-94
23297317-6	2013	The CD41(high) cells sustained intracellular ROS at the initial level for up to 72 h, but CD41(low) cells had reduced ROS by 48 h. The maximum suppressive effect on CD41 expression was observed when N-acetyl cysteine, which is known to act as a ROS scavenger, was administered 48 h after PMA stimulation.	ros	118-121	integrin subunit alpha 2b	Homo sapiens	90-94
23297317-6	2013	The CD41(high) cells sustained intracellular ROS at the initial level for up to 72 h, but CD41(low) cells had reduced ROS by 48 h. The maximum suppressive effect on CD41 expression was observed when N-acetyl cysteine, which is known to act as a ROS scavenger, was administered 48 h after PMA stimulation.	ros	118-121	integrin subunit alpha 2b	Homo sapiens	90-94
23297317-6	2013	The CD41(high) cells sustained intracellular ROS at the initial level for up to 72 h, but CD41(low) cells had reduced ROS by 48 h. The maximum suppressive effect on CD41 expression was observed when N-acetyl cysteine, which is known to act as a ROS scavenger, was administered 48 h after PMA stimulation.	ros	118-121	integrin subunit alpha 2b	Homo sapiens	90-94
23297317-8	2013	There is a possibility that the K562 cell population contains at least two types of radiosensitive megakaryocytic progenitors with respect to ROS production mechanisms, and intracellular ROS levels determine the extent of CD41 expression.	ros	187-190	integrin subunit alpha 2b	Homo sapiens	222-226
23478801-2	2013	Here, for the first time to our knowledge, we reported that neuroglobin (Ngb), an intracellular hexa-coordinated globin serving as an oxygen/reactive oxygen species (ROS) sensor, functions as a tumor suppressor in hepatocelluar carcinoma (HCC).	ros	166-169	neuroglobin	Homo sapiens	60-71
23478801-2	2013	Here, for the first time to our knowledge, we reported that neuroglobin (Ngb), an intracellular hexa-coordinated globin serving as an oxygen/reactive oxygen species (ROS) sensor, functions as a tumor suppressor in hepatocelluar carcinoma (HCC).	ros	166-169	neuroglobin	Homo sapiens	73-76
23478801-13	2013	Therefore, we propose that Ngb controls HCC development by linking oxygen/ROS signals to oncogenic Raf/mitogen-activated protein kinase (MAPK)/Erk signaling.	ros	74-77	neuroglobin	Homo sapiens	27-30
22336250-8	2013	In vitro study by incubating platelets or white cells with PLC demonstrated a significant inhibition of p47(phox) translocation on cellular surface and ROS generated by NOX2 activation.	ros	152-155	cytochrome b-245 beta chain	Homo sapiens	169-173
22336250-9	2013	CONCLUSION: This study suggests that in PAD patients ROS generated by NOX2 contribute to reduce FMD and that the administration of an antioxidant is able to improve arterial dilatation via NOX2 inhibition.	ros	53-56	cytochrome b-245 beta chain	Homo sapiens	70-74
23598272-0	2013	ROS-mediated PARP activity undermines mitochondrial function after permeability transition pore opening during myocardial ischemia-reperfusion.	ros	0-3	poly (ADP-ribose) polymerase family, member 1	Mus musculus	13-17
33262598-15	2020	The suppressive effects of SNHG7 on the relative activity of ROS, the MDA level and apoptosis rate as well as the promotion effect of SNHG7 on cell viability were reversed by miR-9 mimics or sh-SIRT1 in IS cells.	ros	61-64	small nucleolar RNA host gene 7	Mus musculus	27-32
18202321-5	2008	In addition, inhibiting ROS production stimulated by TS/IL-1beta decreased activation of Src, EGFR and p38MAPK, phosphorylation of PTEN, VE-cadherin and beta-catenin, and abrogated the effect of TS/IL-1beta to disorganize adherens junctions, resulting in reduced endothelial permeability and decreased nuclear beta-catenin accumulation.	ros	24-27	Rous sarcoma oncogene	Mus musculus	89-92
23614021-9	2013	HAL2 overexpression in bdf1Delta reduced ROS level and improved mitochondrial function, but not respiration.	ros	41-44	3'(2'),5'-bisphosphate nucleotidase	Saccharomyces cerevisiae S288C	0-4
18202321-5	2008	In addition, inhibiting ROS production stimulated by TS/IL-1beta decreased activation of Src, EGFR and p38MAPK, phosphorylation of PTEN, VE-cadherin and beta-catenin, and abrogated the effect of TS/IL-1beta to disorganize adherens junctions, resulting in reduced endothelial permeability and decreased nuclear beta-catenin accumulation.	ros	24-27	epidermal growth factor receptor	Mus musculus	94-98
18202321-7	2008	CONCLUSIONS: TS interaction with IL-1beta modulates PTEN activity though the ROS/Src/EGFR-p38MAPK pathway.	ros	77-80	Rous sarcoma oncogene	Mus musculus	81-84
18202321-7	2008	CONCLUSIONS: TS interaction with IL-1beta modulates PTEN activity though the ROS/Src/EGFR-p38MAPK pathway.	ros	77-80	epidermal growth factor receptor	Mus musculus	85-89
23353834-7	2013	Treatment of TR-rPCT1 with NAC or an inhibition of TXNIP by AzaS or siTXNIP3 each reduces HG-induced ROS, caspase-3 activation and DNA damage demonstrating that TXNIP up-regulation under chronic hyperglycemia is critically involved in cellular oxidative stress, DNA damage and retinal pericyte apoptosis.	ros	101-104	thioredoxin interacting protein	Rattus norvegicus	51-56
18006113-7	2008	Pharmacologic suppression of HO-1 activity resulted in a marked increase in the ROS generation in cisplatin-treated cells.	ros	80-83	heme oxygenase 1	Homo sapiens	29-33
23353834-7	2013	Treatment of TR-rPCT1 with NAC or an inhibition of TXNIP by AzaS or siTXNIP3 each reduces HG-induced ROS, caspase-3 activation and DNA damage demonstrating that TXNIP up-regulation under chronic hyperglycemia is critically involved in cellular oxidative stress, DNA damage and retinal pericyte apoptosis.	ros	101-104	thioredoxin interacting protein	Rattus norvegicus	70-75
33312388-4	2020	We found that both PD stressors increased mitochondrial Parkin translocation and interaction with Mitofilin that promotes Mitofilin degradation via ubiquitination, which is responsible for reduced mitochondrial membrane potential and increased ROS production.	ros	244-247	inner membrane mitochondrial protein	Homo sapiens	98-107
33312388-4	2020	We found that both PD stressors increased mitochondrial Parkin translocation and interaction with Mitofilin that promotes Mitofilin degradation via ubiquitination, which is responsible for reduced mitochondrial membrane potential and increased ROS production.	ros	244-247	inner membrane mitochondrial protein	Homo sapiens	122-131
18292807-1	2008	In humans, hereditary inactivation of either p22(phox) or gp91(phox) leads to chronic granulomatous disease (CGD), a severe immune disorder characterized by the inability of phagocytes to produce bacteria-destroying ROS.	ros	216-219	calcineurin like EF-hand protein 1	Homo sapiens	45-48
32859750-0	2020	Computationally modeling mammalian succinate dehydrogenase kinetics identifies the origins and primary determinants of ROS production.	ros	119-122	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	35-58
33046554-5	2020	This pathway activation reduces ROS generated by QR2 enzymatic activity, a process that alters the intrinsic properties of CA1 interneurons 3 h following learning, in a form of oxidative eustress.	ros	32-35	carbonic anhydrase 1	Homo sapiens	123-126
18292807-1	2008	In humans, hereditary inactivation of either p22(phox) or gp91(phox) leads to chronic granulomatous disease (CGD), a severe immune disorder characterized by the inability of phagocytes to produce bacteria-destroying ROS.	ros	216-219	paired Ig-like receptor B	Mus musculus	58-62
32989924-7	2020	Mechanistic study demonstrated that ndufa7 depletion promoted ROS production and calcineurin signalling activation.	ros	62-65	NADH:ubiquinone oxidoreductase subunit A7	Danio rerio	36-42
16978743-5	2007	We found that inducible expression of A30P or A53T mutant alpha-synuclein decreased the proteasome activity, increased intracellular ROS levels, and enhanced lactacystin- and H2O2-induced cell death.	ros	133-136	synuclein alpha	Homo sapiens	58-73
33032258-7	2020	Accordingly, Q-PCR results indicate that the higher levels of expression of different ROS scavenging genes (AtP5CS, AtCAT, AtPOD and AtSOD) and abiotic stress related genes (RAB18 and RD29B) were detected in transgenic lines.	ros	86-89	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	108-114
33194027-9	2020	In addition, SNHG15 knockdown suppressed OGD/R-induced apoptosis in SY-SY5Y cells by attenuating intracellular ROS generation and reducing mitochondrial membrane potential (MMP) lost.	ros	111-114	small nucleolar RNA host gene 15	Homo sapiens	13-19
17385235-4	2007	Reactive oxygen and nitrogen species (ROS/RNS) are produced through normal cellular metabolism and are rendered harmless by enzymatic systems.	ros	38-41	FAM20C golgi associated secretory pathway kinase	Homo sapiens	42-45
33117337-4	2020	Our results show that the in vitro treatment with ABL carrying PI5P (ABL/PI5P) enhances bacterial uptake, ROS production, phagosome acidification, and intracellular bacterial killing in human monocyte-derived macrophages (MDMs) with pharmacologically inhibited cystic fibrosis transmembrane conductance regulator channel (CFTR), and improve uptake and intracellular killing of MDR P. aeruginosa in CF macrophages with impaired bactericidal activity.	ros	106-109	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	50-53
33117337-4	2020	Our results show that the in vitro treatment with ABL carrying PI5P (ABL/PI5P) enhances bacterial uptake, ROS production, phagosome acidification, and intracellular bacterial killing in human monocyte-derived macrophages (MDMs) with pharmacologically inhibited cystic fibrosis transmembrane conductance regulator channel (CFTR), and improve uptake and intracellular killing of MDR P. aeruginosa in CF macrophages with impaired bactericidal activity.	ros	106-109	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	69-77
17638544-3	2007	By confocal microscopy, we found that Fas ligand (FasL) induced the formation of LR clusters in the plasma membrane of CAECs, accompanied by aggregation of NAD(P)H oxidase subunits, gp91phox and p47phox, and ROS production.	ros	208-211	Fas ligand	Homo sapiens	38-48
32180468-6	2020	DCFH-DA probe was used to detect the ROS generation.Results: The data showed that the apoptosis and the expression of GFAP were increased significantly with HG treatment.	ros	37-40	glial fibrillary acidic protein	Homo sapiens	118-122
32659346-2	2020	Studies from our laboratory show that the intrinsic pathway proapoptotic proteins BAX and caspase-3 (CASP3) lie upstream of mitochondrial production of oxidative stress-inducing reactive species (RS) such as reactive oxygen and reactive nitrogen species (ROS and RNS) in apoptotic and nonapoptotic neurons in cell culture.	ros	255-258	BCL2-associated X protein	Mus musculus	82-85
17638544-3	2007	By confocal microscopy, we found that Fas ligand (FasL) induced the formation of LR clusters in the plasma membrane of CAECs, accompanied by aggregation of NAD(P)H oxidase subunits, gp91phox and p47phox, and ROS production.	ros	208-211	Fas ligand	Homo sapiens	50-54
32659346-2	2020	Studies from our laboratory show that the intrinsic pathway proapoptotic proteins BAX and caspase-3 (CASP3) lie upstream of mitochondrial production of oxidative stress-inducing reactive species (RS) such as reactive oxygen and reactive nitrogen species (ROS and RNS) in apoptotic and nonapoptotic neurons in cell culture.	ros	255-258	caspase 3	Mus musculus	90-99
32659346-2	2020	Studies from our laboratory show that the intrinsic pathway proapoptotic proteins BAX and caspase-3 (CASP3) lie upstream of mitochondrial production of oxidative stress-inducing reactive species (RS) such as reactive oxygen and reactive nitrogen species (ROS and RNS) in apoptotic and nonapoptotic neurons in cell culture.	ros	255-258	caspase 3	Mus musculus	101-106
17615382-9	2007	Leptin also elicited ROS generation.	ros	21-24	leptin	Homo sapiens	0-6
17615382-11	2007	CONCLUSION: Leptin induces CRP expression in HCAECs via activation of the leptin receptor, increased ROS production, and phosphorylation of ERK1/2.	ros	101-104	leptin	Homo sapiens	12-18
17671895-4	2007	Administration of SMA-pirarubicin micelle under HBO can further enhance the delivery of molecular oxygen that facilitates tumor selective generation of ROS, thus augmenting its antitumor potency.	ros	152-155	immunoglobulin mu binding protein 2	Mus musculus	18-21
17508907-3	2007	On addition of N-acetyl-D-alanine (NADA), a substrate of DAAO, to NLS-DAAO-transfected HeLa cells, a twofold increase in ROS production relative to untreated, transfected control was observed.	ros	121-124	D-amino acid oxidase	Homo sapiens	57-61
32436404-7	2020	Furthermore, the apoptosis rate and ROS generation in flow cytometry assays were significantly increased after the knockdown of PRDX4 expression (p < .05).	ros	36-39	peroxiredoxin 4	Homo sapiens	128-133
17508907-3	2007	On addition of N-acetyl-D-alanine (NADA), a substrate of DAAO, to NLS-DAAO-transfected HeLa cells, a twofold increase in ROS production relative to untreated, transfected control was observed.	ros	121-124	D-amino acid oxidase	Homo sapiens	70-74
17508907-4	2007	Staining of cellular thiols confirmed that NLS-DAAO-induced ROS selectively modified the nuclear thiol pool, whereas the cytoplasmic pool remained unchanged.	ros	60-63	D-amino acid oxidase	Homo sapiens	47-51
33841536-7	2020	Furthermore, results demonstrated that CAP significantly increased ROS generation, mitochondrial membrane potential (MMP) collapse, mitochondrial swelling, and cytochrome c release only in cancerous rat ocular mitochondria but not the normal rat ocular mitochondria.	ros	67-70	sorbin and SH3 domain containing 1	Rattus norvegicus	39-42
17508907-5	2007	Furthermore, NLS-DAAO/NADA-induced ROS caused significant oxidation of the nuclear GSH pool, as measured by nuclear protein S-glutathionylation (Pr-SSG), but under the same conditions, nuclear Trx1 redox state was not altered significantly.	ros	35-38	D-amino acid oxidase	Homo sapiens	17-21
32925168-8	2020	This study explains how activated NK cells survive in the ROS-rich TME and suggests that smokers with lung cancer may benefit from therapies using IL-15-primed NK cells.	ros	58-61	interleukin 15	Homo sapiens	147-152
17428749-7	2007	We conclude that the reversible LMW-PTP activity regulated by ROS-mediated oxidation and TTase/GSH reduction is the likely mechanism of redox signaling in lens epithelial cells.	ros	62-65	acid phosphatase 1, soluble	Mus musculus	32-39
32779670-2	2020	Herein, we report active-targeting, enzyme- and ROS-dual responsive nanoparticles (HPGBCA) consisting of CD44-targeting hyaluronic acid (HA) shells and afatinib (AFT)-loaded, ROS-sensitive poly(l-lysine)-conjugated chlorin e6 (Ce6) derivative nanoparticle cores (PGBCA).	ros	48-51	CD44 molecule (Indian blood group)	Homo sapiens	105-109
16843822-1	2006	A commentary on "ROS-triggered caspase 2 activation and feedback amplification loop in beta-carotene-induced apoptosis".	ros	17-20	caspase 2	Homo sapiens	31-40
32901466-13	2020	CONCLUSION: Our results suggest that VDAC1-/- in H9c2 cells enhances oxidative stress-mediated cell apoptosis that is directly linked to the reduction of mitochondria-bound HKII and concomitantly associated with enhanced ROS production, ECAR, and PPR.	ros	221-224	voltage-dependent anion channel 1	Rattus norvegicus	37-42
32964473-14	2021	Pretreatment of HIBEpiCs with ML221, DPI (Nox4 inhibitor), NAC (ROS inhibitor) or PD98059 (ERK inhibitor) reduced apelin-induced cholangiocyte proliferation.	ros	64-67	NLR family, pyrin domain containing 1A	Mus musculus	59-62
16869728-8	2006	ERalpha translocation in response to exogenous estrogen and mechanical strain was assessed in both ROS 17/2.8 and MLO-Y4 cells.	ros	99-102	estrogen receptor 1	Rattus norvegicus	0-7
32632148-0	2020	IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.	ros	73-76	Rac family small GTPase 1	Homo sapiens	58-62
32632148-12	2020	CONCLUSIONS: Our study indicated an important mechanism by which upregulated IQGAP1 by HBV promoted anoikis resistance, migration and invasion of HCC cells through Rac1-dependent ROS accumulation and activation of Src/FAK signalling, suggesting IQGAP1 as a prognostic indicator and a novel therapeutic target in HCC patients with HBV infection.	ros	179-182	Rac family small GTPase 1	Homo sapiens	164-168
32497629-2	2020	This work aimed to investigate possible influences of dimethyl fumarate (DMF) on streptozotocin (STZ) diabetes-associated vascular complications in rats, exploring its potential to modulate ROS-TXNIP-NLRP3 inflammasome pathway.	ros	190-193	thioredoxin interacting protein	Rattus norvegicus	194-199
17119268-13	2006	A "dual PPARgamma-PPARalpha agonists" (e.g PIO, but ROS poorly activate PPARalpha) might lower glucose and modulate lipids.	ros	52-55	peroxisome proliferator activated receptor alpha	Homo sapiens	18-27
32569778-0	2020	Plasma exosomes protect against cerebral ischemia/reperfusion injury via exosomal HSP70 mediated suppression of ROS.	ros	112-115	heat shock protein family A (Hsp70) member 4	Homo sapiens	82-87
32750647-7	2020	Allantoin reduced the accumulation of ROS by increasing the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and AsA content.	ros	38-41	catalase	Beta vulgaris subsp. vulgaris	120-128
32750647-7	2020	Allantoin reduced the accumulation of ROS by increasing the activities of superoxide dismutase (SOD), peroxidase (POD), catalase (CAT), ascorbate peroxidase (APX), and AsA content.	ros	38-41	catalase	Beta vulgaris subsp. vulgaris	130-133
16584897-7	2006	Flavonoids (1microg/ml) significantly promoted PGC proliferation, which could be markedly inhibited by ROS.	ros	103-106	progastricsin	Gallus gallus	47-50
32862153-6	2020	The results of the KO mice study indicated that FRT reduced ROS activation through inhibition of PARP-1.	ros	60-63	poly (ADP-ribose) polymerase family, member 1	Mus musculus	97-103
32862153-10	2020	To summarize, ROS suppression by PARP-1 knockout in KO mice highlights potential therapeutic target either by PARP-1 inhibition combined with radiation or by treatment with a drug therapy alone.	ros	14-17	poly (ADP-ribose) polymerase family, member 1	Mus musculus	33-39
32862153-10	2020	To summarize, ROS suppression by PARP-1 knockout in KO mice highlights potential therapeutic target either by PARP-1 inhibition combined with radiation or by treatment with a drug therapy alone.	ros	14-17	poly (ADP-ribose) polymerase family, member 1	Mus musculus	110-116
23376831-10	2013	We conclude that TRPM2 channels protected hearts from I/R injury by decreasing generation and enhancing scavenging of ROS, thereby reducing I/R-induced oxidative stress.	ros	118-121	transient receptor potential cation channel subfamily M member 2	Homo sapiens	17-22
23238024-9	2013	The pronounced and selective upregulation of SOD2 points to enhanced ROS levels in the mitochondrial matrix.	ros	69-72	superoxide dismutase 2	Rattus norvegicus	45-49
32872305-6	2020	Our data suggest that an increase of oxidative stress in Panc-1 cells activates a ROS-G4-PARP-1 axis that stimulates the transcription of KRAS.	ros	82-85	KRAS proto-oncogene, GTPase	Homo sapiens	138-142
16632126-5	2006	TNF-alpha significantly increased intracellular ROS generation and then ERK activation, which was blocked by notoginsenoside R1 or DPI and apocynin, inhibitors of NADPH oxidase, or the antioxidant NAC.	ros	48-51	synuclein alpha	Homo sapiens	197-200
23439548-0	2013	Different Forms of Selenoprotein M Differentially Affect Abeta Aggregation and ROS Generation.	ros	79-82	selenoprotein M	Homo sapiens	19-34
16632126-6	2006	Our data demonstrated that TNF-alpha-induced upregulation of fibronectin mRNA and protein levels occurs via activation of ROS/ERK, which was prevented by treatment with notoginsenoside R1, DPI, apocynin, NAC, or MAPK/ERK inhibitors PD098059 and U0126.	ros	122-125	synuclein alpha	Homo sapiens	204-207
22903504-8	2013	Notably, LPS-induced ROS generation can partly facilitate p38 MAPK/JNK/AKT activation to regulate GSK-3beta-mediated Mcl-1 stability, apoptosis, and neutrophilia.	ros	21-24	mitogen-activated protein kinase 8	Mus musculus	67-70
16480945-7	2006	In this report, we show for the first time the expression and function of both sulfoxide reductases together with thioredoxin reductase in the cytosol as well as in the nucleus of epidermal melanocytes which are especially sensitive to ROS.	ros	236-239	peroxiredoxin 5	Homo sapiens	114-135
23041250-8	2013	Scavenging ROS spikes with NAC, mannitol or PBN dose dependently protected macrophages against MetHb induced toxicity, apoptosis and cellular membrane damage.	ros	11-14	NLR family, pyrin domain containing 1A	Mus musculus	27-30
32442538-7	2020	Under AGEs treatment conditions, USP9X overexpression markedly increased the total and nuclear levels, ARE-binding ability, and transcriptional activity of Nrf2, upregulated the protein expressions of Nrf2 downstream genes HO-1 and NQO1, and eventually reduced the excessive production of ROS.	ros	289-292	ubiquitin specific peptidase 9, X-linked	Rattus norvegicus	33-38
32913508-7	2020	With the decrease of ROS, JAK2/STAT3 signaling pathway and its downstream MMP2 and MMP9 expression were downregulated.	ros	21-24	matrix metallopeptidase 9	Homo sapiens	83-87
32913508-9	2020	Thus, we can conclude that ulinastatin attenuates adhesion molecules expression and monocyte-endothelial adhesion, mechanism of which is related that ulinastatin inhibits ROS transfer between the neighboring vascular endothelial cells mediated by Cx43, resulting in the inactivation of JAK2/STAT3 signaling pathway, and its downstream MMP2 and MMP9 expression decrease.	ros	171-174	matrix metallopeptidase 9	Homo sapiens	344-348
16520226-1	2006	A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".	ros	42-45	presenilin 1	Mus musculus	82-85
32402936-5	2020	Further results indicated that the ROS scavenging and cytoprotection effect of 3b might be related to the Nrf2 activation and upregulation of related phase II antioxidant enzymes, such as HO-1 and NQO1.	ros	35-38	heme oxygenase 1	Rattus norvegicus	188-192
24217648-6	2013	The ROS scavenger NAC abrogated these consequences.	ros	4-7	X-linked Kx blood group	Homo sapiens	18-21
23843863-0	2013	Attenuation of Proinflammatory Responses by S-[6]-Gingerol via Inhibition of ROS/NF-Kappa B/COX2 Activation in HuH7 Cells.	ros	77-80	MIR7-3 host gene	Homo sapiens	111-115
16443161-1	2006	The combination of proteomics with highly specific and sensitive affinity techniques is important for the identification of posttranslational modifications by reactive oxygen and nitrogen species (ROS/RNS).	ros	197-200	FAM20C golgi associated secretory pathway kinase	Homo sapiens	201-204
23365696-5	2013	An increase in UCP2 expression can reduce ROS production and affect mitochondrial energy production.	ros	42-45	uncoupling protein 2	Rattus norvegicus	15-19
23326583-9	2013	SIGNIFICANCE: Taken together, these results showed that ATPgammaS induced COX-2 expression and PGE(2) production via a P2 receptor/PKC/NADPH oxidase/ROS/Jak2/STAT3/cPLA(2) signaling pathway in A549 cells.	ros	149-152	phospholipase A2 group IVA	Homo sapiens	164-170
32155298-6	2020	AMP significantly suppressed the intracellular ROS production and expression levels of ROS producing enzymes NADPH oxidase 2 (NOX2) and NOX4.	ros	87-90	cytochrome b-245 beta chain	Homo sapiens	109-124
32155298-6	2020	AMP significantly suppressed the intracellular ROS production and expression levels of ROS producing enzymes NADPH oxidase 2 (NOX2) and NOX4.	ros	87-90	cytochrome b-245 beta chain	Homo sapiens	126-130
32802129-0	2020	Buyang Huanwu Decoction Promotes Angiogenesis after Cerebral Ischemia by Inhibiting the Nox4/ROS Pathway.	ros	93-96	NADPH oxidase 4	Rattus norvegicus	88-92
16339585-3	2005	In this study, we show that ROS production in HCs involves a flavin-containing oxidase dependent on Ca2+, but not on GTP-Rac1 or protein kinase C. This suggests the involvement of the nonphagocytic NADPH oxidase NOX5, an enzyme found in lymphoid tissues, but not in circulating lymphocytes.	ros	28-31	NADPH oxidase 5	Homo sapiens	212-216
32802129-8	2020	BYHWD exerts angiogenic effects against cerebral ischemic injury through the downregulation of Nox4, which results in the reduction of ROS generation.	ros	135-138	NADPH oxidase 4	Rattus norvegicus	95-99
32482385-7	2020	Our findings revealed that TSPO ligands significantly inhibited proinflammatory gene expression, inflammasome-mediated caspase-1 activation, lipid accumulation and intracellular ROS levels in stressed ARPE-19 cells.	ros	178-181	translocator protein	Homo sapiens	27-31
23161516-0	2013	A novel andrographolide derivative AL-1 exerts its cytotoxicity on K562 cells through a ROS-dependent mechanism.	ros	88-91	ephrin A5	Homo sapiens	35-39
23161516-6	2013	Functional studies confirmed that AL-1 induced apoptosis of K562 cells through a ROS-dependent mechanism, and anti-oxidant, N-acetyl-L-cysteine, could completely block AL-1-induced cytotoxicity, implicating that ROS generation played a vital role in AL-1 cytotoxicity.	ros	81-84	ephrin A5	Homo sapiens	34-38
23161516-6	2013	Functional studies confirmed that AL-1 induced apoptosis of K562 cells through a ROS-dependent mechanism, and anti-oxidant, N-acetyl-L-cysteine, could completely block AL-1-induced cytotoxicity, implicating that ROS generation played a vital role in AL-1 cytotoxicity.	ros	81-84	ephrin A5	Homo sapiens	168-172
23161516-6	2013	Functional studies confirmed that AL-1 induced apoptosis of K562 cells through a ROS-dependent mechanism, and anti-oxidant, N-acetyl-L-cysteine, could completely block AL-1-induced cytotoxicity, implicating that ROS generation played a vital role in AL-1 cytotoxicity.	ros	81-84	ephrin A5	Homo sapiens	168-172
23161516-6	2013	Functional studies confirmed that AL-1 induced apoptosis of K562 cells through a ROS-dependent mechanism, and anti-oxidant, N-acetyl-L-cysteine, could completely block AL-1-induced cytotoxicity, implicating that ROS generation played a vital role in AL-1 cytotoxicity.	ros	212-215	ephrin A5	Homo sapiens	34-38
23161516-6	2013	Functional studies confirmed that AL-1 induced apoptosis of K562 cells through a ROS-dependent mechanism, and anti-oxidant, N-acetyl-L-cysteine, could completely block AL-1-induced cytotoxicity, implicating that ROS generation played a vital role in AL-1 cytotoxicity.	ros	212-215	ephrin A5	Homo sapiens	168-172
23161516-6	2013	Functional studies confirmed that AL-1 induced apoptosis of K562 cells through a ROS-dependent mechanism, and anti-oxidant, N-acetyl-L-cysteine, could completely block AL-1-induced cytotoxicity, implicating that ROS generation played a vital role in AL-1 cytotoxicity.	ros	212-215	ephrin A5	Homo sapiens	168-172
23161516-8	2013	The current work reveals that a novel andrographolide derivative AL-1 exerts its anticancer cytotoxicity through a ROS-dependent DNA damage and mitochondrial-mediated apoptosis mechanism.	ros	115-118	ephrin A5	Homo sapiens	65-69
23326634-2	2013	LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 and ROS-dependent phenomena.	ros	22-25	toll-like receptor 9	Mus musculus	100-104
23326634-2	2013	LOX-1 antibody or the ROS inhibitor apocynin attenuated ox-LDL-mediated autophagy, mtDNA damage and TLR9 expression, suggesting that these events are LOX-1 and ROS-dependent phenomena.	ros	160-163	toll-like receptor 9	Mus musculus	100-104
22951908-8	2012	GPx1 deficiency led to an accumulation of ROS/RNS and subsequent death of GBM cells after induction of oxidative stress.	ros	42-45	glutathione peroxidase 1	Homo sapiens	0-4
16339585-7	2005	This allows the inactivation of SHP-1 by NOX5-generated ROS and contributes to the maintenance of the constitutive activation of HCs.	ros	56-59	NADPH oxidase 5	Homo sapiens	41-45
23117583-18	2012	Comparing bioluminescence in wildtype mice to p47(phox-/-) mice enables us to delineate the specific contribution of ROS generated by p47(phox)-containing NADPH oxidase to the bioluminescent signal in these models.	ros	117-120	cytochrome b-245 beta chain	Homo sapiens	50-54
16095823-4	2005	LPS+IL-(1beta) induced oxidative injury as assessed by ROS production (29%), GSH depletion (11%) and loss of mitochondrial activity (22%).	ros	55-58	interleukin 1 alpha	Homo sapiens	4-13
22895800-9	2012	The intracellular ROS levels of the thermochemotherapy group were elevated significantly compared with those of other groups, and these changes could be reversed using the ROS inhibitor NAC but not a PI3K inhibitor (wortmannin).	ros	18-21	X-linked Kx blood group	Homo sapiens	186-189
22895800-9	2012	The intracellular ROS levels of the thermochemotherapy group were elevated significantly compared with those of other groups, and these changes could be reversed using the ROS inhibitor NAC but not a PI3K inhibitor (wortmannin).	ros	172-175	X-linked Kx blood group	Homo sapiens	186-189
15849737-7	2005	However, secretory type phospholipase A(2) inhibitors (glycyrrhizin and aristolochic acid) and a free radical scavenger (5,5-dimethyl pyrroline N-oxide, DMPO) could attenuate not only beta-BuTX-induced cytotoxicity but also ROS production and caspase-3 activation.	ros	224-227	phospholipase A2 group IB	Rattus norvegicus	24-41
22964500-2	2012	There is compelling evidence supporting the notion that Abeta-induced cytotoxicity is mediated though the generation of ROS.	ros	120-123	amyloid beta precursor protein	Rattus norvegicus	56-61
22753949-4	2012	CPS specifically increased Atg4C mRNA expression and induced oxidation of Atg4C protein by ROS generation.	ros	91-94	carbamoyl-phosphate synthetase 1	Mus musculus	0-3
15806174-0	2005	HSP25 inhibits radiation-induced apoptosis through reduction of PKCdelta-mediated ROS production.	ros	82-85	heat shock protein family B (small) member 1	Homo sapiens	0-5
15841206-3	2005	Here we show that uncoupling of nitric oxide synthase-3 (NOS3) plays a major role in pressure load-induced myocardial ROS and consequent chamber remodeling/hypertrophy.	ros	118-121	nitric oxide synthase 3, endothelial cell	Mus musculus	32-55
22402261-7	2012	Our findings demonstrate that ROS-induced oxidative damage to SBPase affects growth, development, and chloroplast biogenesis in Arabidopsis through inhibiting carbon assimilation efficiency.	ros	30-33	sedoheptulose-bisphosphatase	Arabidopsis thaliana	62-68
23157748-16	2012	Up-regulation of miR-383 knockdowns the expression of PRDX3, inhibits proliferation and promotes apoptosis of Daoy cells, leading to increased intracellular ROS and decreased levels of mitochondrial membrane potential.	ros	157-160	microRNA 383	Homo sapiens	17-24
15841206-3	2005	Here we show that uncoupling of nitric oxide synthase-3 (NOS3) plays a major role in pressure load-induced myocardial ROS and consequent chamber remodeling/hypertrophy.	ros	118-121	nitric oxide synthase 3, endothelial cell	Mus musculus	57-61
23157748-16	2012	Up-regulation of miR-383 knockdowns the expression of PRDX3, inhibits proliferation and promotes apoptosis of Daoy cells, leading to increased intracellular ROS and decreased levels of mitochondrial membrane potential.	ros	157-160	peroxiredoxin 3	Homo sapiens	54-59
15841206-11	2005	Thus, pressure overload triggers NOS3 uncoupling as a prominent source of myocardial ROS that contribute to dilatory remodeling and cardiac dysfunction.	ros	85-88	nitric oxide synthase 3, endothelial cell	Mus musculus	33-37
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	ros	4-7	SUMO specific peptidase 3	Homo sapiens	86-91
22684029-9	2012	The ROS levels differentially modified cysteines 243 and 532 in the cysteine protease SENP3, regulating the interaction of SENP3 with p300 to cause different SUMOylation of p300, thus shifting HIF-1 transcriptional activity.	ros	4-7	SUMO specific peptidase 3	Homo sapiens	123-128
15790872-13	2005	ROS-derived DRMs were dramatically enriched in caveolin-1, contained significant amounts of transducin-alpha and c-Src, and were relatively devoid of arrestin.	ros	0-3	caveolin 1	Bos taurus	47-57
22684029-10	2012	CONCLUSION: The shift of HIF-1 transactivation by ROS is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.	ros	50-53	SUMO specific peptidase 3	Homo sapiens	120-125
22684029-10	2012	CONCLUSION: The shift of HIF-1 transactivation by ROS is correlated with and dependent on the biphasic redox sensing of SENP3 that leads to the differential SENP3/p300 interaction and the consequent fluctuation in the p300 SUMOylation status.	ros	50-53	SUMO specific peptidase 3	Homo sapiens	157-162
15773552-4	2005	Further, to identify the ROS family members implicated in the HOX-1 induction, we also exposed cells to various non-thiol antioxidants: dimethyl sulfoxide, dimetylthiourea, sodium salicylate, sodium formate, uric acid, catalase, and superoxide dismutase.	ros	25-28	heme oxygenase 1	Homo sapiens	62-67
15545996-6	2004	Consistent with unstable alpha-Hb, AHSP(-/-) erythrocytes contained increased ROS and evidence of oxidative damage.	ros	78-81	alpha hemoglobin stabilizing protein	Homo sapiens	35-39
22155845-4	2012	A dominant allele of WAK2 requires kinase activity and activates a stress response that includes an increased ROS accumulation and the up-regulation of numerous genes involved in pathogen resistance, wounding, and cell wall biogenesis.	ros	110-113	wall-associated kinase 2	Arabidopsis thaliana	21-25
15545996-7	2004	Moreover, purified recombinant AHSP inhibited ROS production by alpha-Hb in solution.	ros	46-49	alpha hemoglobin stabilizing protein	Homo sapiens	31-35
15199066-4	2004	This observation has been extended to naturally expressed noggin and sclerostin from the rat osteosarcoma cell line, ROS 17/2.8, supporting a role for the complex in natural systems.	ros	117-120	noggin	Rattus norvegicus	58-64
22751303-5	2012	Notably, many dividing root cells of the rhd2 Arabidopsis thaliana mutants, lacking the RHD2/AtRBOHC protein function, displayed aberrations, comparable to those induced by low ROS levels.	ros	177-180	NADPH/respiratory burst oxidase protein D	Arabidopsis thaliana	41-45
22095288-0	2012	PKD is a kinase of Vps34 that mediates ROS-induced autophagy downstream of DAPk.	ros	39-42	protein kinase D1	Homo sapiens	0-3
22391342-6	2012	The application of various signal pathway inhibitors revealed that besides the canonical ROS-DNA damage signal, ERK pathway modulated the activation of PARP-1.	ros	89-92	poly (ADP-ribose) polymerase family, member 1	Mus musculus	152-158
15197348-11	2004	This data also argues that GST- MDA-7 induces two parallel pro-apoptotic pathways via ROS-dependent and -independent mechanisms.	ros	86-89	interleukin 24	Homo sapiens	32-37
22052190-7	2012	PATZ1 knockdown increased ROS levels, and pretreatment with N-acetylcysteine abolished EC senescence induced by PATZ1 knockdown.	ros	26-29	POZ/BTB and AT hook containing zinc finger 1	Homo sapiens	0-5
15037024-3	2004	We here found that ROS 17/2.8 osteosarcoma cells and osteoblasts have different expression of alpha5 integrin, executing different fibronectin fibrillogenesis.	ros	19-22	fibronectin 1	Rattus norvegicus	131-142
22052190-9	2012	These results suggest that PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging.	ros	106-109	POZ/BTB and AT hook containing zinc finger 1	Homo sapiens	27-32
22095488-10	2012	In addition, Mfn2 overexpression inhibited activation of p38, and the accumulation of ROS; prevented mitochondrial dysfunction; and reduced the synthesis of collagen IV, but did not affect apoptosis of kidney cells.	ros	86-89	mitofusin 2	Rattus norvegicus	13-17
22288910-5	2012	This 2-ABP-induced COX-2 expression was attenuated by ROS scavenger NAC and NADPH oxidase inhibitors apocynin and DPI.	ros	54-57	X-linked Kx blood group	Homo sapiens	68-71
14674678-4	2003	In outer segments, ROS-GCs sense fluctuations in Ca(2+) via two Ca(2+)-binding proteins, which have been termed GCAP1 and GCAP2.	ros	19-22	guanylate cyclase activator 1B	Homo sapiens	122-127
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	10-13	X-linked Kx blood group	Homo sapiens	33-36
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	99-102	X-linked Kx blood group	Homo sapiens	33-36
22002103-7	2012	Moreover, ROS scavengers such as NAC, tiron, and quercetin inhibited nucleoside derivative-induced ROS generation and apoptosis by blocking the sequential activation of caspase-2 and -3, indicating the role of ROS in caspase-2-mediated apoptosis.	ros	99-102	X-linked Kx blood group	Homo sapiens	33-36
22217266-8	2012	The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by Ang II, indicating that Ang II uses ROS as a second messenger to regulate STAT1 activity.	ros	44-47	signal transducer and activator of transcription 1	Homo sapiens	163-168
22217266-8	2012	The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by Ang II, indicating that Ang II uses ROS as a second messenger to regulate STAT1 activity.	ros	125-128	signal transducer and activator of transcription 1	Homo sapiens	63-68
22217266-8	2012	The antioxidant N-acetyl-L-cysteine reduced ROS production and STAT1 activity induced by Ang II, indicating that Ang II uses ROS as a second messenger to regulate STAT1 activity.	ros	125-128	signal transducer and activator of transcription 1	Homo sapiens	163-168
12927798-4	2003	Digestion of cell-surface HS with heparitinase interferes with BMP-7-mediated Smad phosphorylation in ROS 17/2.8 osteoblastic cells.	ros	102-105	bone morphogenetic protein 7	Rattus norvegicus	63-68
12927798-6	2003	Addition of exogenous heparin to ROS 17/2.8 cells prevents BMP-7-mediated Smad phosphorylation rather than enhances the BMP-7 signal, suggesting that HS should be anchored on the plasma membrane for BMP signaling.	ros	33-36	bone morphogenetic protein 7	Rattus norvegicus	59-64
22508052-8	2012	NQO2 siRNA treatment could reduce vascular or intracellular ROS level and decrease the phosphorylation of the ERK1/2 in balloon injured artery walls and cultured rat VSMCs.	ros	60-63	N-ribosyldihydronicotinamide:quinone reductase 2	Rattus norvegicus	0-4
12927798-7	2003	Moreover, BMP-7 binding to ROS 17/2.8 cells is inhibited by chlorate treatment and exogenous application of heparin.	ros	27-30	bone morphogenetic protein 7	Rattus norvegicus	10-15
32724477-12	2020	Mechanistically, ERO1L-mediated ROS generation was essential for its oncogenic activities.	ros	32-35	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	17-22
12962720-1	2003	OBJECTIVE: Patients with myelodysplasia (MDS) show a disturbed production of ROS in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) in granulocyte-macrophage colony-stimulating factor (GM-CSF)-primed neutrophils.	ros	77-80	colony stimulating factor 2	Homo sapiens	152-200
12962720-1	2003	OBJECTIVE: Patients with myelodysplasia (MDS) show a disturbed production of ROS in response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP) in granulocyte-macrophage colony-stimulating factor (GM-CSF)-primed neutrophils.	ros	77-80	colony stimulating factor 2	Homo sapiens	202-208
22474421-8	2012	TXNIP ablation in vitro prevents ROS generation, restores ATP level and autophagic LC3B induction in rMC1.	ros	33-36	thioredoxin interacting protein	Rattus norvegicus	0-5
12661006-0	2003	Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21).	ros	46-49	ret proto-oncogene	Homo sapiens	21-45
22489124-8	2012	The protein expression of prohibitin was negatively correlated with the RIF index, protein expression of TGF-beta1, Col-IV, fibronectin, alpha-SMA or cleaved Caspase-3, ROS generation and the cell apoptosis index (each p &lt; 0.01).	ros	169-172	prohibitin 1	Rattus norvegicus	26-36
32463541-7	2020	Mechanistically, CBS silencing significantly elevates ROS production, thereby leading to reduced mitofusin 2 (MFN2) expression, decouple endoplasmic reticulum-mitochondria contacts, increased mitochondria fission, enhanced receptor-mediated mitophagy, and increased EC death.	ros	54-57	mitofusin 2	Homo sapiens	97-108
32463541-7	2020	Mechanistically, CBS silencing significantly elevates ROS production, thereby leading to reduced mitofusin 2 (MFN2) expression, decouple endoplasmic reticulum-mitochondria contacts, increased mitochondria fission, enhanced receptor-mediated mitophagy, and increased EC death.	ros	54-57	mitofusin 2	Homo sapiens	110-114
12661006-1	2003	The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is an orphan receptor that is aberrantly expressed in neoplasms of the central nervous system.	ros	64-67	ret proto-oncogene	Homo sapiens	33-57
32625226-5	2020	These changes in biometric and biochemical properties were accompanied by changes in expression levels of the genes coding for ROS-producing (RBOH) and scavenging (SOD, CAT, GST) enzymes and their specific activity.	ros	127-130	catalase isozyme 1	Cucumis sativus	169-172
12661006-1	2003	The transmembrane proto-oncogene receptor tyrosine kinase (RTK) ROS is an orphan receptor that is aberrantly expressed in neoplasms of the central nervous system.	ros	64-67	ret proto-oncogene	Homo sapiens	59-62
12553006-5	2002	There is a time-gat between the early activation of Smad-dependent TIEG and the accumulation of ROS, therefore other participants that start the increase in mitochondrial membrane permeability should be identified.	ros	96-99	Kruppel like factor 10	Homo sapiens	67-71
32460807-0	2020	Correction to: Connexin32 plays a crucial role in ROS-mediated endoplasmic reticulum stress apoptosis signaling pathway in ischemia reperfusion-induced acute kidney injury.	ros	50-53	gap junction protein beta 1	Homo sapiens	15-25
32509151-0	2020	Autophagy Induced by ROS Aggravates Testis Oxidative Damage in Diabetes via Breaking the Feedforward Loop Linking p62 and Nrf2.	ros	21-24	nucleoporin 62	Homo sapiens	114-117
21704734-8	2012	PKCbeta acting through mitochondrial proteins could play a role in protecting the cells from death by e.g. influencing ROS and ATP production after ischemia in CA2-4,DG region of the hippocampus.	ros	119-122	protein kinase C, beta	Rattus norvegicus	0-7
21984036-10	2012	Our results show that PMA can induce MUC5AC expression by activation of the Duox1-ROS-TACE-TGF-alpha-EGFR signaling pathway.	ros	82-85	ADAM metallopeptidase domain 17	Homo sapiens	86-90
22815910-8	2012	During ICAM-1 activation of PKCalpha, the XO-generated ROS did not oxidize PKCalpha.	ros	55-58	intercellular adhesion molecule 1	Homo sapiens	7-13
22815910-11	2012	CONCLUSIONS: Crosslinking ICAM-1 stimulated XO/ROS which activated ERK1/2 that then activated PKCalpha.	ros	47-50	intercellular adhesion molecule 1	Homo sapiens	26-32
12392766-13	2002	Synaptosomes from APOE knock-out mice are more vulnerable to Abeta-induced oxidative stress (protein oxidation, lipid peroxidation, and ROS generation) than are those from wild-type mice.	ros	136-139	amyloid beta (A4) precursor protein	Mus musculus	61-66
22496641-2	2012	Based on studies in macrophages, it is likely that ROS and lysosomal destabilization regulated by Syk activation may also be involved.	ros	51-54	spleen associated tyrosine kinase	Homo sapiens	98-101
22496641-8	2012	Blocking Syk activation by kinase inhibitors or RNAi reduced Syk phosphorylation, lysosomal destabilization, ROS production, and caspase-1 activation in Ceacam1-/- neutrophils.	ros	109-112	spleen associated tyrosine kinase	Homo sapiens	9-12
12052825-5	2002	A scavenger of reactive oxygenated species (ROS), N-acetylcysteine (NAC) at 20 mm, completely suppresses the activation of MAP kinases and ASK1, suggesting a role for oxidative stress in the activation mechanism.	ros	44-47	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	139-143
22977591-7	2011	In addition, increased intracellular ROS accumulation appeared in the Trr1 shRNA knockdown cells compared to the RKO wild-type cells, in proportion to a relatively higher fraction of the DNA damage reporter protein phosphorylated histone "gamma-H2AX".	ros	37-40	thioredoxin reductase 1	Homo sapiens	70-74
32411168-7	2020	Moreover, Arabidopsis mutant analysis demonstrated that three ROS and redox homeostatasis related DEGs of identified DEM-DEG pairs, GSTU2, GSTU5, and RBOHF contributed to the AGO2-mediated defense against S. sclerotiorum.	ros	62-65	glutathione S-transferase tau 2	Arabidopsis thaliana	132-137
32181166-5	2020	Primary injury results in excess of reactive oxidative stress (ROS) which is known from NADPH oxidase 2 (Nox2).	ros	63-66	cytochrome b-245 beta chain	Homo sapiens	88-103
32181166-5	2020	Primary injury results in excess of reactive oxidative stress (ROS) which is known from NADPH oxidase 2 (Nox2).	ros	63-66	cytochrome b-245 beta chain	Homo sapiens	105-109
31811910-5	2020	Thioredoxin reductase 1 (TR1), a pivotal target gene of Nrf2, was observed to promote 5-FU resistance by reducing intracellular ROS levels.	ros	128-131	thioredoxin reductase 1	Homo sapiens	0-23
12031896-9	2002	We conclude that p47phox is important for vascular ROS production and redox-modulated signaling and gene expression in VSMC.	ros	51-54	neutrophil cytosolic factor 1	Mus musculus	17-24
31811910-5	2020	Thioredoxin reductase 1 (TR1), a pivotal target gene of Nrf2, was observed to promote 5-FU resistance by reducing intracellular ROS levels.	ros	128-131	thioredoxin reductase 1	Homo sapiens	25-28
31960779-6	2020	Mief1 knockdown sustained mitochondrial membrane potential and reduced mitochondrial ROS overproduction.	ros	85-88	mitochondrial elongation factor 1	Homo sapiens	0-5
31444399-10	2020	The endotoxin was shown to upregulate the expression of TRPM7 via the TLR4/NOX-2/ROS/NF-kappaB pathway and induce a TRPM7-dependent EC Ca2+ overload.	ros	81-84	transient receptor potential cation channel subfamily M member 7	Homo sapiens	56-61
31444399-10	2020	The endotoxin was shown to upregulate the expression of TRPM7 via the TLR4/NOX-2/ROS/NF-kappaB pathway and induce a TRPM7-dependent EC Ca2+ overload.	ros	81-84	cytochrome b-245 beta chain	Homo sapiens	75-80
21550418-5	2011	Since we previously found that selenite lowered ROS in NARP cybrids, we hypothesised that selenite could also modulate mitochondrial biogenesis in these cells.	ros	48-51	neuronal pentraxin 2	Homo sapiens	55-59
21605584-8	2011	Both NADPH oxidases flavoprotein inhibitor DPI and Nox4 siRNA blocked arsenic-induced ROS production, whereas Nox4 overexpression suppressed the inhibitory effects of GSE on arsenic-induced ROS production and NADPH oxidase activities, as well as expression of TGF-beta1, type I procollagen (Coll-I) and alpha-smooth muscle actin (alpha-SMA) mRNA.	ros	86-89	NADPH oxidase 4	Rattus norvegicus	51-55
21605584-8	2011	Both NADPH oxidases flavoprotein inhibitor DPI and Nox4 siRNA blocked arsenic-induced ROS production, whereas Nox4 overexpression suppressed the inhibitory effects of GSE on arsenic-induced ROS production and NADPH oxidase activities, as well as expression of TGF-beta1, type I procollagen (Coll-I) and alpha-smooth muscle actin (alpha-SMA) mRNA.	ros	190-193	NADPH oxidase 4	Rattus norvegicus	110-114
21433060-0	2011	beta-Catenin mediates cyclic strain-stimulated cardiomyogenesis in mouse embryonic stem cells through ROS-dependent and integrin-mediated PI3K/Akt pathways.	ros	102-105	catenin (cadherin associated protein), beta 1	Mus musculus	0-12
21433060-11	2011	Collectively, these results suggest that beta-catenin-mediated signaling is required for cyclic strain-stimulated cardiomyogenesis through ROS-dependent and integrin-mediated PI3K-Akt signaling cascades.	ros	139-142	catenin (cadherin associated protein), beta 1	Mus musculus	41-53
31492896-0	2020	Inhibition of Slug effectively targets leukemia stem cells via the Slc13a3/ROS signaling pathway.	ros	75-78	snail family transcriptional repressor 2	Homo sapiens	14-18
11950237-14	2002	The plasma membrane enriched fractions (isolated at densities of 1.08 and 1.125 g ml(-1)) containing tagged peripherin/rds and the Delta10 mutant promoted membrane fusion with ROS plasma membrane vesicles.	ros	176-179	peripherin 2	Canis lupus familiaris	119-122
11739633-9	2001	In contrast, ROS osteoblastic cells, which differentially sort Cx43 and Cx46, did not form Cx43/Cx46 heteromers.	ros	13-16	gap junction protein alpha 3	Homo sapiens	72-76
31731100-0	2020	Anti-inflammatory cytokines IL-35 and IL-10 block atherogenic lysophosphatidylcholine-induced, mitochondrial ROS-mediated innate immune activation, but spare innate immune memory signature in endothelial cells.	ros	109-112	interleukin 10	Homo sapiens	38-43
11500942-7	2001	The 1.4 kb 5" flanking sequence of the Cbfa1 gene directed high levels of transcriptional activity in Ros 17/2.8 and MC3T3-E1 osteoblasts compared to non-osteoblasts Cos-7 cells, but this construct also exhibited high levels of expression in C310T1/2, L929, and C2C12 cells as well as NIH3T3 cells.	ros	102-105	runt related transcription factor 2	Mus musculus	39-44
32912078-11	2020	In addition, VEGF-PEG-PLA-DOX micelles displayed a larger cell viability inhibitory effect as measured via MTT assays and greater cell apoptosis induction through in vitro ROS levels compared with PEG-PLA-DOX micelles or free DOX.	ros	172-175	vascular endothelial growth factor A	Mus musculus	13-17
31835256-10	2019	Furthermore, prior treatment with ROS scavenger, NAC significantly attenuated the nicotine-induced caspase-1 activity, IL-1beta production, podocin and nephrin reduction in podocytes.	ros	34-37	NPHS1 adhesion molecule, nephrin	Homo sapiens	152-159
31493144-12	2019	PL combined with oxaliplatin markedly suppressed the activity of TrxR1, resulting in the accumulation of ROS and, thereby, DNA damage induction and p38 and JNK signaling pathway activation.	ros	105-108	thioredoxin reductase 1	Mus musculus	65-70
21233414-7	2011	The NO/ROS balance is also important during Th1 to Th2 transition.	ros	7-10	negative elongation factor complex member C/D	Homo sapiens	44-47
21479273-7	2011	Moreover, PKG stimulation of Kir6.2/SUR2A channels in intact cells was abrogated by ROS/H(2)O(2) scavenging, antagonism of calmodulin, and blockade of calcium/calmodulin-dependent protein kinase II (CaMKII), respectively.	ros	84-87	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	29-35
21406103-7	2011	Global transcript profiling of seeds/siliques from wild type and transgenic plants under transient hypoxic and standard conditions using Affymetrix ATH1 chips revealed a rearrangement of transcriptional networks by AtHb1 overexpression under non-stress conditions, which included the induction of transcripts related to ABA synthesis and signaling, receptor-like kinase- and MAP kinase-mediated signaling pathways, WRKY transcription factors and ROS metabolism.	ros	446-449	hemoglobin 1	Arabidopsis thaliana	215-220
10884379-8	2000	Here, using frog rod photoreceptor outer segments (ROS) isolated by a new method, we show that Cdk5 is involved in light-dependent Pgamma phosphorylation in vivo.	ros	51-54	cyclin dependent kinase 5	Homo sapiens	95-99
21029719-4	2011	Application of Tat to MAGI cells caused increases in ROS formation that were prevented by both pharmacologic NADPH oxidase inhibitors and by siRNA Nox2, but not by other inhibitors of pro-oxidant enzymes or siRNA Nox4.	ros	53-56	cytochrome b-245 beta chain	Homo sapiens	147-151
10884379-12	2000	These observations, together with immunological data showing the presence of Cdk5 in ROS, suggest that Cdk5 is involved in light-dependent Pgamma phosphorylation in ROS and that the phosphorylation is significant and reversible.	ros	85-88	cyclin dependent kinase 5	Homo sapiens	77-81
21253614-13	2011	CONCLUSIONS/SIGNIFICANCE: We present evidence that NADPH oxidase derived ROS plays a role in the direct Treg mediated suppression of CD4+ effector T cells in a process that is blocked by thiol-containing antioxidants, NADPH oxidase inhibitors or a lack of Ncf1 expression in Tregs and Teffs.	ros	73-76	CD4 antigen	Mus musculus	133-136
10884379-12	2000	These observations, together with immunological data showing the presence of Cdk5 in ROS, suggest that Cdk5 is involved in light-dependent Pgamma phosphorylation in ROS and that the phosphorylation is significant and reversible.	ros	85-88	cyclin dependent kinase 5	Homo sapiens	103-107
10884379-12	2000	These observations, together with immunological data showing the presence of Cdk5 in ROS, suggest that Cdk5 is involved in light-dependent Pgamma phosphorylation in ROS and that the phosphorylation is significant and reversible.	ros	165-168	cyclin dependent kinase 5	Homo sapiens	103-107
30810907-7	2019	Knockout of GMF in BV2-G cells significantly attenuated oxidative stress via reduced ROS production and calcium flux.	ros	85-88	glia maturation factor beta	Homo sapiens	12-15
10967546-5	2000	While c-fos was induced in UMR cells, both c-fos and jun B were induced in ROS cells.	ros	75-78	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-58
31727865-8	2019	Moreover, ROS and IL-1beta inhibition suppressed the cellular senescence induced by S100A9, whereas NLRP3 overexpression and exogenous IL-1beta supplementation induces cellular senescence.	ros	10-13	S100 calcium binding protein A9	Homo sapiens	84-90
20217214-11	2011	The down-regulation of ICAM-1 by short hairpin RNA in MCF10A cells led to the induction of psoriasin, calgranulin-A, calgranulin-B, and MUC1, and we demonstrated that these up-regulations were not ROS dependent.	ros	197-200	intercellular adhesion molecule 1	Homo sapiens	23-29
10913916-8	2000	These data show that strain as well as estrogen stimulates increased proliferation in ROS 17/2.8 cells and increased ER alpha-related ERE activity in ROS cells transfected with ER alpha.	ros	150-153	estrogen receptor 1	Rattus norvegicus	117-125
21799876-8	2011	We demonstrated that LAD2 cells have a more robust glutathione (GSH)-dependent antioxidative system compared to THP-1 cells and are therefore protected against the actions of ROS generated in an SCF-dependent manner.	ros	175-178	KIT ligand	Homo sapiens	195-198
31283965-6	2019	Knockdown of TRB3 significantly decreased the MPP+-induced reduction of cell viability, augment of cell apoptosis and accumulation of ROS, inhibited the phosphorylation of p38 and JNK, and promoted the phosphorylation of AKT, in vitro.	ros	134-137	tribbles pseudokinase 3	Mus musculus	13-17
10913916-8	2000	These data show that strain as well as estrogen stimulates increased proliferation in ROS 17/2.8 cells and increased ER alpha-related ERE activity in ROS cells transfected with ER alpha.	ros	150-153	estrogen receptor 1	Rattus norvegicus	177-185
20508647-9	2010	The addition of N-acetyl-L-cysteine (ROS scavenger) to As(2)O(3)-treated cells reversed changes in SnoN protein and the autophagic/apoptotic response.	ros	37-40	SKI like proto-oncogene	Homo sapiens	99-103
10913916-11	2000	This indicates that ROS cells" early responses to mechanical strain involve ER alpha and estrogen-responsive genes.	ros	20-23	estrogen receptor 1	Rattus norvegicus	76-84
31608051-4	2019	High ROS levels activate a novel PGAM5 phosphatase dependent cell-death pathway, called oxeiptosis.	ros	5-8	phosphoglycerate mutase family member 5	Mus musculus	33-38
10997555-3	2000	The results showed that incubation with various concentration of TGF-beta1 (1-15 ng/ml) significantly increased the adhesion activity (1.4 to 2.5 folds) of ROS 17/2.8 to fibronectin and type I collagen (p&lt;0.01), whereas the adhesion activity to laminin and type IV collagen was slightly elevated (1.1 to 1.5 folds).	ros	156-159	fibronectin 1	Rattus norvegicus	170-181
10804015-9	2000	The in vivo effects of hPTH(1-38) on OPG mRNA were confirmed in isolated primary osteoblast cultures derived from either metaphyseal or diaphyseal bone as well as in ROS 17/2.8 osteosarcoma cells.	ros	166-169	TNF receptor superfamily member 11B	Rattus norvegicus	37-40
31492195-4	2019	RESULTS: The study showed that 50 mug/ml astilbin could inhibit the growth and reduce the accumulation of ROS in HaCaT cells stimulated by IL-17 and TNF-alpha.	ros	106-109	interleukin 17A	Homo sapiens	139-144
30982974-11	2019	Furthermore, ROS inhibitor N-acetyl-L-cysteine (NAC) also suppressed BaP co-exposure-induced expression of epithelial TSLP, IL-33, and IL-25.	ros	13-16	interleukin 33	Mus musculus	124-129
21051935-9	2010	Moreover, we show that increased accumulation of cytoplasmic ROS in apx1 mutants reduced the NPR1-dependent gene expression.	ros	61-64	ascorbate peroxidase 1	Arabidopsis thaliana	68-72
21051935-9	2010	Moreover, we show that increased accumulation of cytoplasmic ROS in apx1 mutants reduced the NPR1-dependent gene expression.	ros	61-64	regulatory protein (NPR1)	Arabidopsis thaliana	93-97
20571037-8	2010	Zymosan-stimulated production of ROS was increased dramatically in a M-CSF-dependent manner in Lnk KO macrophages.	ros	33-36	colony stimulating factor 1 (macrophage)	Mus musculus	69-74
31136780-7	2019	Notably, MPG substantially suppressed the significant elevation of ROS production in hepatocytes of mice intoxicated with CCl4.	ros	67-70	chemokine (C-C motif) ligand 4	Mus musculus	122-126
20890104-3	2010	Our research into mechanisms of TSC2 regulation helped uncover a pathway upstream of TSC2 that is regulated by cytoplasmic ATM in response to ROS initiated by ATM activation of LKB1 and AMPK.	ros	142-145	TSC complex subunit 2	Homo sapiens	32-36
20890104-3	2010	Our research into mechanisms of TSC2 regulation helped uncover a pathway upstream of TSC2 that is regulated by cytoplasmic ATM in response to ROS initiated by ATM activation of LKB1 and AMPK.	ros	142-145	TSC complex subunit 2	Homo sapiens	85-89
10720779-3	2000	We show experimental evidence that co-expression of TGF-alpha and c-myc transgenes in mouse liver promotes overproduction of ROS and thus creates an oxidative stress environment.	ros	125-128	transforming growth factor alpha	Mus musculus	52-61
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	ros	120-123	matrix metallopeptidase 9	Homo sapiens	45-50
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	ros	120-123	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
20432471-8	2010	Taken together, our data indicate that MMP-2/MMP-9 down-regulation in caffeine-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/c-Jun pathway.	ros	120-123	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	193-198
20512627-0	2010	N,N-Dimethyl phytosphingosine sensitizes HL-60/MX2, a multidrug-resistant variant of HL-60 cells, to doxorubicin-induced cytotoxicity through ROS-mediated release of cytochrome c and AIF.	ros	142-145	MX dynamin like GTPase 2	Homo sapiens	47-50
20512627-10	2010	The ROS scavenger NAC efficiently suppressed not only ROS generation, but also caspase-3-mediated PARP cleavage, apoptosis, and release of cytochrome c and AIF, indicating a role of ROS in combined Dox + DMPS treatment-induced apoptotic death signaling.	ros	4-7	X-linked Kx blood group	Homo sapiens	18-21
20512627-10	2010	The ROS scavenger NAC efficiently suppressed not only ROS generation, but also caspase-3-mediated PARP cleavage, apoptosis, and release of cytochrome c and AIF, indicating a role of ROS in combined Dox + DMPS treatment-induced apoptotic death signaling.	ros	4-7	apoptosis inducing factor mitochondria associated 1	Homo sapiens	156-159
20512627-10	2010	The ROS scavenger NAC efficiently suppressed not only ROS generation, but also caspase-3-mediated PARP cleavage, apoptosis, and release of cytochrome c and AIF, indicating a role of ROS in combined Dox + DMPS treatment-induced apoptotic death signaling.	ros	54-57	X-linked Kx blood group	Homo sapiens	18-21
20512627-10	2010	The ROS scavenger NAC efficiently suppressed not only ROS generation, but also caspase-3-mediated PARP cleavage, apoptosis, and release of cytochrome c and AIF, indicating a role of ROS in combined Dox + DMPS treatment-induced apoptotic death signaling.	ros	54-57	X-linked Kx blood group	Homo sapiens	18-21
31436314-7	2019	Moreover, AtCAD7 was stabilized by Avr3a-like effectors and involved in suppression of pathogen-associated molecular pattern -triggered immunity, including callose deposition, ROS burst, and WRKY33 expression.	ros	176-179	cinnamyl alcohol dehydrogenase 7	Arabidopsis thaliana	10-16
31140779-6	2019	The lead, MFM 4, chelates and sequesters metal ions, disrupts their redox cycles, prevents excessive ROS production and oxidative stress, ameliorates oxidative DNA damage and mitochondrial dysfunction, and modulates Nrf2 protein signaling under oxidative stress conditions by eliminating the toxic stress elements.	ros	101-104	LIM domain binding 3	Homo sapiens	10-15
10703921-5	2000	Northern blot hybridization in primary cultures of fetal rat calvaria and in human SaOS-2 and rat ROS osteoblast-like cells showed a relationship between N-cadherin messenger RNA expression and cell-to-cell adhesion, morphological differentiation, and alkaline phosphatase and osteocalcin gene expression.	ros	98-101	cadherin 2	Rattus norvegicus	154-164
30805771-8	2019	However, we also found that depletion of SSeCKS aggravated the LPS-induced vascular endothelial dysfunction, upregulated pro-inflammatory proteins and phosphorylation level of PKCzeta, increased ROS formation, decreased extracellular-signal-regulated kinase 5 (ERK5) transcriptional activity, and reduced eNOS expression.	ros	195-198	A-kinase anchoring protein 12	Homo sapiens	41-47
20336484-10	2010	DEX significantly increased neuronal death in organotypic hippocampal slice cultures of rat brain with enhanced generation of ROS, which was effectively inhibited by ginsenoside Rb1 and Rg3.	ros	126-129	RB transcriptional corepressor 1	Rattus norvegicus	178-181
20204677-0	2010	ROS-NFkappaB mediates TGF-beta1-induced expression of urokinase-type plasminogen activator, matrix metalloproteinase-9 and cell invasion.	ros	0-3	matrix metallopeptidase 9	Homo sapiens	92-118
20156602-6	2010	Furthermore, BAI potently inhibits the TNF-alpha-induced increase in ROS generation in A549 cells, suggesting that inhibition of ROS generation is maybe involved in the BAI-mediated inhibition of TNF-alpha-induced ICAM-1 down-regulation to A549 cells.	ros	69-72	intercellular adhesion molecule 1	Homo sapiens	214-220
20156602-6	2010	Furthermore, BAI potently inhibits the TNF-alpha-induced increase in ROS generation in A549 cells, suggesting that inhibition of ROS generation is maybe involved in the BAI-mediated inhibition of TNF-alpha-induced ICAM-1 down-regulation to A549 cells.	ros	129-132	intercellular adhesion molecule 1	Homo sapiens	214-220
31078114-7	2019	In addition, the suppression of NLRP3 inflammasome activation by UFL1 was partly mediated through the regulation of NF-kappaB signaling and ROS production.	ros	140-143	UFM1 specific ligase 1	Bos taurus	65-69
10571055-1	1999	The membrane bound guanylyl cyclase (GC) photoreceptor membrane GC1 (ROS-GCI) of photoreceptor cells synthesizes cGMP, the intracellular transmitter of vertebrate phototransduction.	ros	69-72	solute carrier family 25 member 22	Homo sapiens	64-67
31184118-4	2019	The ROS levels increased significantly after exposure to juglone, which paralleled increases in the mRNA and protein expression of p21 and decreases in the levels of CDK2, cdc25A, CHK1, and cyclin A.	ros	4-7	cell division cycle 25A	Homo sapiens	172-178
20392947-11	2010	This is the first work to demonstrate the essential role of p66(shc) in mediating requisite mitochondrial and energetic compensation after preconditioning and suggests a mechanism by which protein and organelle damage mediated by ROS can increase HSP70.	ros	230-233	SHC adaptor protein 1	Homo sapiens	64-67
20392947-11	2010	This is the first work to demonstrate the essential role of p66(shc) in mediating requisite mitochondrial and energetic compensation after preconditioning and suggests a mechanism by which protein and organelle damage mediated by ROS can increase HSP70.	ros	230-233	heat shock protein family A (Hsp70) member 4	Homo sapiens	247-252
10369877-1	1999	Mice carrying a targeted disruption of the rhodopsin gene develop a severe degenerative retinopathy, failing to elaborate rod photoreceptor outer segments (ROS), having no recordable rod electroretinogram (ERG) and losing all of their rod cells over a period of approximately 12 weeks.	ros	156-159	rhodopsin	Mus musculus	43-52
20346214-11	2010	The ROS expression level was higher in the cells of thermo-chemotherapy group (102.14 +/- 18.34) than in the other groups (P &lt; 0.05), which could be inhibited by NAC(28.01 +/- 1.19), but not by the PI3K inhibitor Wortmannin (99.87 +/- 8.35).	ros	4-7	X-linked Kx blood group	Homo sapiens	165-168
20002769-10	2009	CONCLUSIONS: CD82/KAI1 is an excellent marker for distinguishing chromophobe RCCs from other types of renal cell tumours, especially from ROs with overlapping phenotype.	ros	138-141	CD82 molecule	Homo sapiens	13-17
20002769-10	2009	CONCLUSIONS: CD82/KAI1 is an excellent marker for distinguishing chromophobe RCCs from other types of renal cell tumours, especially from ROs with overlapping phenotype.	ros	138-141	CD82 molecule	Homo sapiens	18-22
19837945-5	2009	However, only WT-PLD2 expression increased PTH-dependent PLD activity in ROS cells.	ros	73-76	phospholipase D2	Homo sapiens	17-21
31262713-7	2019	Antioxidative function of FAM129B is analyzed by measuring ROS levels with DCF/flow cytometry, Nrf2 activation using luciferase reporter assay and determination of downstream gene expression by qPCR and wester blotting.	ros	59-62	niban apoptosis regulator 2	Homo sapiens	26-33
31222000-0	2019	Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis.	ros	88-91	adrenomedullin	Rattus norvegicus	0-14
31222000-0	2019	Adrenomedullin alleviates the pyroptosis of Leydig cells by promoting autophagy via the ROS-AMPK-mTOR axis.	ros	88-91	mechanistic target of rapamycin kinase	Rattus norvegicus	97-101
31222000-7	2019	Like NAC, ADM dose-dependently reduced LPS-induced cytotoxicity and ROS overproduction.	ros	68-71	adrenomedullin	Rattus norvegicus	10-13
10320338-5	1999	The arrestin mutant R175Q bound to light-activated, unphosphorylated rhodopsin in ROS disk membranes.	ros	82-85	rhodopsin	Bos taurus	69-78
31222000-14	2019	ADM may protect the steroidogenic functions of Leydig cells against pyroptosis by activating autophagy via the ROS-AMPK-mTOR axis.	ros	111-114	adrenomedullin	Rattus norvegicus	0-3
31222000-14	2019	ADM may protect the steroidogenic functions of Leydig cells against pyroptosis by activating autophagy via the ROS-AMPK-mTOR axis.	ros	111-114	mechanistic target of rapamycin kinase	Rattus norvegicus	120-124
9812998-8	1998	Furthermore, Smad2 overexpression also suppressed transcriptional activity of the 1-kilobase pair osteocalcin gene promoter, which was linked to chloramphenicol acetyltransferase reporter gene in both ROS and PRC cells.	ros	201-204	SMAD family member 2	Rattus norvegicus	13-18
9686616-5	1998	The production of ROS by PMN was significantly inhibited by two chemically different PAF receptor antagonists (WEB 2170 and CV 3988), suggesting an autocrine stimulation of PMN by PAF newly synthesized after the challenge with IL-12.	ros	18-21	PCNA clamp associated factor	Homo sapiens	85-88
31205024-3	2019	The present study demonstrated that during the process of metabolism of immunoglobulin FLCs, ROS activated the STAT1 pathway in proximal tubule epithelium.	ros	93-96	signal transducer and activator of transcription 1	Homo sapiens	111-116
31209224-7	2019	Significantly increased cleavage of caspase-8 and subsequent high levels of apoptosis were found in livers of GsdmD-/- mice after HS/R, a relatively mild ROS-induced liver injury.	ros	154-157	gasdermin D	Mus musculus	110-115
31209224-8	2019	However, during more severe APAP-mediated ROS-induced liver injury, caspase-8 cleavage in GsdmD-/- liver was inhibited compared with WT, resulting in accumulation of pro-caspase-8 and increased levels of necroptosis.	ros	42-45	gasdermin D	Mus musculus	90-95
32666016-7	2020	Osteocytes isolated from CSF-1KO mice were less viable and showed increased intracellular ROS, elevated NADPH oxidase activity/Nox4 protein, activation of mTOR/S6K, and downstream apoptosis signals compared with WT osteocytes.	ros	90-93	colony stimulating factor 1 (macrophage)	Mus musculus	25-30
32666016-15	2020	Taken together, our findings suggest a novel link between CSF-1, Nox4-derived ROS, and osteocyte survival/function that is crucial for osteocyte-mediated bone remodeling.	ros	78-81	colony stimulating factor 1 (macrophage)	Mus musculus	58-63
9686616-5	1998	The production of ROS by PMN was significantly inhibited by two chemically different PAF receptor antagonists (WEB 2170 and CV 3988), suggesting an autocrine stimulation of PMN by PAF newly synthesized after the challenge with IL-12.	ros	18-21	PCNA clamp associated factor	Homo sapiens	180-183
9571173-5	1998	Thus, GCAP1 and GCAP2 act through different ROS-GCs and through two different cyclase domains.	ros	44-47	guanylate cyclase activator 1B	Homo sapiens	16-21
30925291-9	2019	When TRPM2-mediated calcium influx is inhibited, mitochondria are dysfunctional, cellular bioenergetics are reduced, production of ROS is increased, and autophagy and DNA repair are impaired, decreasing tumor growth and increasing chemotherapy sensitivity.	ros	131-134	transient receptor potential cation channel subfamily M member 2	Homo sapiens	5-10
30825547-5	2019	In line with the alleviated ROS levels, tambulin treatment led to upregulated mRNA expression of ROS scavenging genes viz., sod-1, sod-3, and ctl-2.	ros	97-100	Superoxide dismutase [Cu-Zn]	Caenorhabditis elegans	124-129
9572418-6	1998	The activity of alpha-GLUC was inversely correlated with ROS generation after 12-myristate, 13-acetate phorbol ester stimulation (r=-0.27, n=104), and both alpha-GLUC activity and total output were inversely correlated with the concentration of peroxidase-positive white blood cells among samples with &gt; or =1x10(6)/ml of these cells (r=-0.30 and -0.19, n=165).	ros	57-60	sucrase-isomaltase	Homo sapiens	16-26
30573782-0	2019	B7-H3 promotes multiple myeloma cell survival and proliferation by ROS-dependent activation of Src/STAT3 and c-Cbl-mediated degradation of SOCS3.	ros	67-70	CD276 antigen	Mus musculus	0-5
30573782-10	2019	These data indicate B7-H3"s important role in the activation of ROS/Src/c-Cbl pathway in multiple myeloma which integrates redox regulation and sustained STAT3 activation at the level of degradation of STAT3 suppressor.	ros	64-67	CD276 antigen	Mus musculus	20-25
9043648-1	1997	An attempt was made to reveal the mode of action of protons and salts on the recently discovered GTP gamma S-dependent interaction of bovine retinal rod outer segments (ROS)1 nucleoside diphosphate kinase (NDP kinase) with the complex between bleached visual receptor rhodopsin and retinal G-protein transducin in bovine ROS membranes.	ros	169-172	rhodopsin	Bos taurus	268-277
31138329-0	2019	ROS-mediated activation and mitochondrial translocation of CaMKII contributes to Drp1-dependent mitochondrial fission and apoptosis in triple-negative breast cancer cells by isorhamnetin and chloroquine.	ros	0-3	collapsin response mediator protein 1	Mus musculus	81-85
31113439-11	2019	By inhibiting TrxR1 activity, WZ35 combined with cisplatin markedly induced the production of ROS, activated p38 and JNK signaling pathways, and eventually induced apoptosis of gastric cancer cells.	ros	94-97	thioredoxin reductase 1	Mus musculus	14-19
9043648-2	1997	The properties of recombinant rat NDP kinase alpha, that is immunologically similar to the soluble NDP kinase from bovine ROS preparation, have been studied in solution by means of protein fluorescence at different pH and salt concentrations and results were compared with pH and salt effects on the binding of NDP kinase alpha to bleached bovine ROS membranes.	ros	122-125	NME/NM23 nucleoside diphosphate kinase 1	Rattus norvegicus	34-50
9043648-2	1997	The properties of recombinant rat NDP kinase alpha, that is immunologically similar to the soluble NDP kinase from bovine ROS preparation, have been studied in solution by means of protein fluorescence at different pH and salt concentrations and results were compared with pH and salt effects on the binding of NDP kinase alpha to bleached bovine ROS membranes.	ros	347-350	NME/NM23 nucleoside diphosphate kinase 1	Rattus norvegicus	34-50
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	21-24	NADPH oxidase 4	Rattus norvegicus	144-148
9043648-3	1997	The results suggest that NDP kinase alpha itself may serve as a target for protons and salts and mediates their effects on the interaction between the enzyme and ROS membranes.	ros	162-165	NME/NM23 nucleoside diphosphate kinase 1	Rattus norvegicus	25-41
8970887-7	1996	The conventional alpha and beta I isozymes, but not gamma, were present in each of the osteoblasts examined; PKC-beta II was detectable in all but the ROS 24/1 line.	ros	151-154	phospholipase C, beta 2	Rattus norvegicus	109-120
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	21-24	ras homolog family member A	Rattus norvegicus	163-167
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	21-24	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	168-173
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	149-152	NADPH oxidase 4	Rattus norvegicus	16-20
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	149-152	ras homolog family member A	Rattus norvegicus	29-33
8663211-9	1996	In addition, cotransfection studies in ROS 17/2.8 osteosarcoma cells using an Msx2 expression vector showed that Msx2 inhibits a COL1A1 promoter-chloramphenicol acetyltransferase construct.	ros	39-42	msh homeobox 2	Rattus norvegicus	113-117
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	149-152	NADPH oxidase 4	Rattus norvegicus	144-148
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	149-152	ras homolog family member A	Rattus norvegicus	163-167
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	149-152	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	168-173
31130857-15	2019	Additionally, NOX4/ROS and RhoA/ROCK1 constitute a new target for UA antifibrosis treatment.	ros	19-22	NADPH oxidase 4	Rattus norvegicus	14-18
8679716-5	1996	In UMR 106 cells 1,25-(OH)2D3 and PTH caused a synergistic up-regulation of the vitamin D receptor (VDR) which was accompanied by a synergistic induction of VDR mRNA expression whereas in both ROS 17/2.8 and MG-63 cells no interaction was observed.	ros	193-196	vitamin D receptor	Rattus norvegicus	80-98
8679716-5	1996	In UMR 106 cells 1,25-(OH)2D3 and PTH caused a synergistic up-regulation of the vitamin D receptor (VDR) which was accompanied by a synergistic induction of VDR mRNA expression whereas in both ROS 17/2.8 and MG-63 cells no interaction was observed.	ros	193-196	vitamin D receptor	Rattus norvegicus	100-103
31114548-3	2019	B(a)P exposure induced ROS mediated steroidogenic imbalance via activation of p38MAPK and repression of testosterone level as well as other steroidogenic enzymes like CYPIIA1, 3beta-HSD, 17beta-HSD expressions.	ros	23-26	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	176-185
8741521-7	1996	ROS 17/2.8 and MG 63 cells were found to express T beta R-I, T beta R-II, and T beta R-III, and their cell growth was inhibited by TGF-beta, whereas alkaline phosphatase activity was stimulated.	ros	0-3	transforming growth factor beta receptor 1	Homo sapiens	49-90
31017975-5	2019	In this study, we provide evidence that considerable levels of p62-mediated selective autophagy are spontaneously induced, and correlate with ROS-Keap1-NRF2 pathway activity, in virus-transformed cells.	ros	142-145	nucleoporin 62	Homo sapiens	63-66
31178965-0	2019	ROS-Induced GATA4 and GATA6 Downregulation Inhibits StAR Expression in LPS-Treated Porcine Granulosa-Lutein Cells.	ros	0-3	GATA binding protein 4	Homo sapiens	12-17
31178965-8	2019	Elimination of LPS-stimulated ROS by melatonin or vitamin C could restore the expressions of GATA4, GATA6, and StAR.	ros	30-33	GATA binding protein 4	Homo sapiens	93-98
7588324-8	1995	In contrast, OA does inhibit the formation of complexes interacting with both the OC and osteopontin VDREs; immunoprecipitation studies using 32P-labeled ROS 17/2.8 cells reveal that OA treatment result in ligand-independent hyperphosphorylation of the VDR.	ros	154-157	vitamin D receptor	Rattus norvegicus	101-104
7649079-5	1995	Incubation of ROS 17/2.8 cells with 0.5 nM 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] led to up-regulation of VDR content by 340-370% of the control value.	ros	14-17	vitamin D receptor	Rattus norvegicus	107-110
30539651-4	2019	We employed tunicamycin as a model of ER stress and used tubular cells and mice overexpressing myo-inositol oxygenase (MIOX), an enzyme involved in glycolytic events with excessive generation of ROS.	ros	195-198	myo-inositol oxygenase	Mus musculus	95-117
30539651-4	2019	We employed tunicamycin as a model of ER stress and used tubular cells and mice overexpressing myo-inositol oxygenase (MIOX), an enzyme involved in glycolytic events with excessive generation of ROS.	ros	195-198	myo-inositol oxygenase	Mus musculus	119-123
7649079-9	1995	Quantitation of VDR messenger RNA by reverse transcription-polymerase chain reaction showed that PTH-(1-34) and -(1-31) at 10(-7) M, but not PTH-(3-34) and -(13-34), inhibited ROS 17/2.8 cell VDR gene expression in both the absence and presence of 1,25-(OH)2D3.	ros	176-179	vitamin D receptor	Rattus norvegicus	16-19
30539651-5	2019	Concomitant treatment of tunicamycin and transfection of cells with MIOX-pcDNA led to a marked generation of ROS, which was reduced by MIOX-siRNA.	ros	109-112	myo-inositol oxygenase	Mus musculus	68-72
30539651-5	2019	Concomitant treatment of tunicamycin and transfection of cells with MIOX-pcDNA led to a marked generation of ROS, which was reduced by MIOX-siRNA.	ros	109-112	myo-inositol oxygenase	Mus musculus	135-139
8903933-4	1995	The recombinant mutants were tested for their ability to phosphorylate rhodopsin present in purified bovine ROS membranes which serves as a substrate for betaARK1.	ros	108-111	rhodopsin	Bos taurus	71-80
30739530-2	2019	Exposing these cells to the melanocortin 5 receptor agonist (MCR5) PG-901 (10-10M), for 9 d reduced ROS generation, the number of exosomes released and their VEGF content.	ros	100-103	melanocortin 5 receptor	Homo sapiens	28-51
20514224-7	2009	The same reports shows that Arabidopsis ROS- and PAMP-activated MAP kinase 3 (MPK3) is essential for stomatal innate response.	ros	40-43	mitogen-activated protein kinase 3	Arabidopsis thaliana	64-76
20514224-7	2009	The same reports shows that Arabidopsis ROS- and PAMP-activated MAP kinase 3 (MPK3) is essential for stomatal innate response.	ros	40-43	mitogen-activated protein kinase 3	Arabidopsis thaliana	78-82
20111678-6	2009	Moreover, resveratrol and the ROS scavengers, NAC and alpha-tocopherol, abolished CTN-stimulated intracellular oxidative stress and apoptosis.	ros	30-33	X-linked Kx blood group	Homo sapiens	46-49
19364500-6	2009	Notably, levels of ROS were rapidly increased upon UV-irradiation and the ROS scavenger NAC inhibits UV-induced senescence of Akt1(-/-) MEFs, suggesting that UV light induces premature senescence in Akt1(-/-) MEFs by modulating intracellular levels of ROS.	ros	74-77	NLR family, pyrin domain containing 1A	Mus musculus	88-91
30709405-16	2019	CONCLUSIONS: In conclusion, the previous results showed that Apelin 13 protected against I/R-induced ROS-mediated inflammation and oxidative stress through activating the AMPK/GSK-3beta pathway by AR/Galpha/PLC/IP3/CaMKK signaling, and further upregulated the expression of Nrf2-regulated antioxidant enzymes.	ros	101-104	apelin	Rattus norvegicus	61-67
7991605-3	1994	Protein kinase A was necessary for desensitization of rat osteosarcoma cells (ROS 17/2.8), whereas the contribution of beta ARK to desensitization was insignificant.	ros	78-81	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-16
19366706-7	2009	Hyperoxia caused rapid activation and redistribution of Rac1, and IQGAP1 to cell periphery, and down-regulation of Rac1, and IQGAP1 attenuated hyperoxia-induced tyrosine phosphorylation of Src and cortactin and ROS generation.	ros	211-214	Rac family small GTPase 1	Homo sapiens	115-119
19337996-0	2009	IFN-gamma-STAT1 signal regulates the differentiation of inducible Treg: potential role for ROS-mediated apoptosis.	ros	91-94	signal transducer and activator of transcription 1	Mus musculus	10-15
18952046-2	2009	ROS production at state 4 due to electron backflow from mGPDH was low, but after inhibition of electron transport with antimycin A high rates of mGPDH-dependent ROS production were observed in liver, heart and brain mitochondria.	ros	0-3	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	56-61
18952046-2	2009	ROS production at state 4 due to electron backflow from mGPDH was low, but after inhibition of electron transport with antimycin A high rates of mGPDH-dependent ROS production were observed in liver, heart and brain mitochondria.	ros	0-3	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	145-150
18952046-2	2009	ROS production at state 4 due to electron backflow from mGPDH was low, but after inhibition of electron transport with antimycin A high rates of mGPDH-dependent ROS production were observed in liver, heart and brain mitochondria.	ros	161-164	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	145-150
30674691-7	2019	We propose that this regulatory mechanism assists in the activation of phosphorylated AtPIP2;1 during circadian regulation of K ros.	ros	128-131	plasma membrane intrinsic protein 2A	Arabidopsis thaliana	86-94
7829990-1	1994	Insulin-like growth factor-I (IGF-I) has been reported to mediate the effects of oestradiol-17 beta in the osteoblast-like osteosarcoma cell line ROS 17/2.8 and to stimulate directly cell proliferation in cell cultures derived from rat calvaria.	ros	146-149	insulin-like growth factor 1	Rattus norvegicus	0-28
30593977-6	2019	However, the concomitant deletion of the SOD1 gene encoding the superoxide dismutase 1 resulted in a distinct phenotype: double deletion strains lacking SCO1 or SCO2 and SOD1 are highly sensitive to oxidative stress and show dramatically increased ROS levels.	ros	248-251	putative thioredoxin peroxidase SCO2	Saccharomyces cerevisiae S288C	161-165
30643688-10	2019	Quantitative real-time PCR analysis showed that biofertilizer + SAP significantly down-regulated the expression levels of genes involved in ROS scavenging (TaCAT, CsCAT, TaAPX, and CsAPX2), ethylene biosynthesis (TaACO2, CsACO1, and CsACS1), stress response (TaDHN3, TaLEA, and CsLEA11), salicylic acid (TaPR1-1a and CsPR1-1a), and transcription activation (TaNAC2D and CsNAC35) in plants under drought stress.	ros	140-143	pathogenesis-related protein 1	Cucumis sativus	317-325
18952046-3	2009	When this ROS production was related to activity of mGPDH, many-fold higher ROS production was found in contrast to succinate- (39-, 28-, 3-fold) or pyruvate plus malate-dependent ROS production (32-, 96-, 5-fold).	ros	10-13	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	52-57
18952046-3	2009	When this ROS production was related to activity of mGPDH, many-fold higher ROS production was found in contrast to succinate- (39-, 28-, 3-fold) or pyruvate plus malate-dependent ROS production (32-, 96-, 5-fold).	ros	76-79	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	52-57
18952046-3	2009	When this ROS production was related to activity of mGPDH, many-fold higher ROS production was found in contrast to succinate- (39-, 28-, 3-fold) or pyruvate plus malate-dependent ROS production (32-, 96-, 5-fold).	ros	76-79	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	52-57
18952046-4	2009	This specific rate of mGPDH-dependent ROS production was also exceedingly higher (28-, 66-, 22-fold) compared to that in BAT.	ros	38-41	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	22-27
18952046-5	2009	mGPDH-dependent ROS production was localized to the dehydrogenase+CoQ and complex III, the latter being the highest in all mitochondria but BAT.	ros	16-19	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	0-5
18952046-6	2009	Our results demonstrate high efficiency of mGPDH-dependent ROS production in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT.	ros	59-62	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	43-48
18952046-6	2009	Our results demonstrate high efficiency of mGPDH-dependent ROS production in mammalian mitochondria with a low content of mGPDH and suggest its endogenous inhibition in BAT.	ros	59-62	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	122-127
31345154-5	2019	Moreover, Jab1-siRNA induces apoptosis by enhancing ROS generation and caspase-3 activation.	ros	52-55	COP9 signalosome subunit 5	Homo sapiens	10-14
7829990-1	1994	Insulin-like growth factor-I (IGF-I) has been reported to mediate the effects of oestradiol-17 beta in the osteoblast-like osteosarcoma cell line ROS 17/2.8 and to stimulate directly cell proliferation in cell cultures derived from rat calvaria.	ros	146-149	insulin-like growth factor 1	Rattus norvegicus	30-35
7829990-4	1994	We found that IGF-I stimulated, in a dose- and time-dependent manner, the specific activity of creatine kinase (CK, a marker of skeletal cell division), in both female and male calvarial bone cells, in ROS 17/2.8 cells and in epiphyseal cartilage cell cultures.	ros	202-205	insulin-like growth factor 1	Rattus norvegicus	14-19
7877617-3	1994	We have found and cloned a cDNA for rat Msx-2 (Hox 8.1) from a ROS 17/2.8 library and detect high levels of expression in various osteoblastic cell lines (ROS 17/2.8, RCT3, RCT1) as well as in culture passage 3 neonatal rat calvarial osteoblastic cells.	ros	63-66	msh homeobox 2	Rattus norvegicus	40-45
30933439-0	2019	TRPM2 Silencing Causes G2/M Arrest and Apoptosis in Lung Cancer Cells via Increasing Intracellular ROS and RNS Levels and Activating the JNK Pathway.	ros	99-102	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	0-5
30933439-11	2019	Mechanistically, TRPM2 downregulation causes an increase in the intracellular levels of reactive oxygen (ROS) and nitrogen (RNS) species, which in turn causes DNA damage and JNK activation leading to G2/M arrest, and an ultimate cell death.	ros	105-108	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	17-22
30933439-11	2019	Mechanistically, TRPM2 downregulation causes an increase in the intracellular levels of reactive oxygen (ROS) and nitrogen (RNS) species, which in turn causes DNA damage and JNK activation leading to G2/M arrest, and an ultimate cell death.	ros	105-108	mitogen-activated protein kinase 8	Mus musculus	174-177
20130808-3	2009	The DOC-induced increase in beclin-1 expression was ROS-dependent.	ros	52-55	beclin 1	Homo sapiens	28-36
18931033-5	2008	SAA significantly decreased endothelial nitric oxide (NO) synthase (eNOS) mRNA and protein levels as well as NO bioavailability, whereas it increased ROS in both artery rings and HCAECs.	ros	150-153	serum amyloid A1 cluster	Homo sapiens	0-3
7877617-3	1994	We have found and cloned a cDNA for rat Msx-2 (Hox 8.1) from a ROS 17/2.8 library and detect high levels of expression in various osteoblastic cell lines (ROS 17/2.8, RCT3, RCT1) as well as in culture passage 3 neonatal rat calvarial osteoblastic cells.	ros	63-66	msh homeobox 2	Rattus norvegicus	47-54
17560688-2	2008	Possible mechanisms underlying Abeta-induced neuronal cytotoxicity include excess production of reactive oxidative species (ROS) and apoptosis.	ros	124-127	amyloid beta precursor protein	Rattus norvegicus	31-36
7877617-3	1994	We have found and cloned a cDNA for rat Msx-2 (Hox 8.1) from a ROS 17/2.8 library and detect high levels of expression in various osteoblastic cell lines (ROS 17/2.8, RCT3, RCT1) as well as in culture passage 3 neonatal rat calvarial osteoblastic cells.	ros	155-158	msh homeobox 2	Rattus norvegicus	40-45
17560688-5	2008	Abeta treatments increased ROS production in PC12 cells.	ros	27-30	amyloid beta precursor protein	Rattus norvegicus	0-5
7877617-3	1994	We have found and cloned a cDNA for rat Msx-2 (Hox 8.1) from a ROS 17/2.8 library and detect high levels of expression in various osteoblastic cell lines (ROS 17/2.8, RCT3, RCT1) as well as in culture passage 3 neonatal rat calvarial osteoblastic cells.	ros	155-158	msh homeobox 2	Rattus norvegicus	47-54
17560688-6	2008	Overexpression of Ngb but not Ngb mutant in the PC12 cells significantly attenuated Abeta-induced ROS production and lipids peroxidation.	ros	98-101	amyloid beta precursor protein	Rattus norvegicus	84-89
8194478-4	1994	Gel mobility shift studies of [32P]VDRE binding to ROS 17/2.8 cell nuclear extract revealed that TNF-alpha inhibits 1,25-(OH)2D3 stimulated formation of specific retinoid X receptor/vitamin D receptor (RXR/VDR)-DNA complexes in vitro.	ros	51-54	vitamin D receptor	Rattus norvegicus	35-38
18662586-3	2008	We have investigated the ability of NGAL to prevent H(2)O(2) toxicity, which is considered to be the classical inducer of oxidative stress caused by ROS generation in an in vitro model.	ros	149-152	lipocalin 2	Homo sapiens	36-40
31343125-9	2019	Additionally, the liver of CCl4-treated mice exhibited a marked increase in proinflammatory signals, such as increased expression of HSP70 and increased levels of proinflammatory cytokines and ROS.	ros	193-196	chemokine (C-C motif) ligand 4	Mus musculus	27-31
7912552-3	1994	At the same time we found that a Ca(2+)-sensitive complex of p26 and a protein with apparent M(r) 67 kDa, presumably rhodopsin kinase, is present in the ROS extract.	ros	153-156	recoverin	Bos taurus	61-64
29745322-7	2019	Inhibition of CIC or ACLY by different synthetic and natural molecules results in reduction of NO, ROS and PGE2 levels suggesting that the citrate pathway can be a new target to be addressed in inflammation.	ros	99-102	ATP citrate lyase	Homo sapiens	21-25
30699406-1	2019	BACKGROUND: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation.	ros	196-199	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	12-50
30699406-1	2019	BACKGROUND: Transient receptor potential ankyrin 1 (TRPA1) is an ion channel known to mediate nociception and neurogenic inflammation, and to be activated by reactive oxygen and nitrogen species (ROS and RNS) produced at the sites of inflammation.	ros	196-199	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	52-57
30699406-2	2019	Because neurogenic inflammation as well as the release of ROS and RNS are typical features of early stages of allergic responses, we hypothesized that TRPA1 may be involved in triggering and/or amplifying allergic inflammation.	ros	58-61	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	151-156
30439413-7	2019	On the other hand, cyclo(His-Pro)-mediated ROS attenuation, not linked to Nrf2 activation in this cellular model, is ascribed to increased soluble SOD1 activity due to the up-regulation of Hsp70 and Hsp27 expression.	ros	43-46	heat shock protein family A (Hsp70) member 4	Homo sapiens	189-194
18467643-4	2008	Nox4 overexpression substantially increased basal ROS generation whereas ROS generation in response to angiotensin II and tumor necrosis factor (TNF)alpha was enhanced in Nox2-overexpressing cells.	ros	73-76	cytochrome b-245 beta chain	Homo sapiens	171-175
7912552-3	1994	At the same time we found that a Ca(2+)-sensitive complex of p26 and a protein with apparent M(r) 67 kDa, presumably rhodopsin kinase, is present in the ROS extract.	ros	153-156	G protein-coupled receptor kinase 7	Bos taurus	117-133
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	55-58	X-linked Kx blood group	Homo sapiens	180-183
31401057-5	2019	In addition, we found that reactive oxidative species (ROS) accumulation plays a casual role in PFOS-initiated JNK activation, as treatment with ROS scavenger N-acetyl-l-cysteine (NAC) abrogated PFOS-induced mitochondrial and nuclear translocation of phosphorylated JNK (p-JNK).	ros	145-148	X-linked Kx blood group	Homo sapiens	180-183
1658637-0	1991	Vitamin D receptor phosphorylation in transfected ROS 17/2.8 cells is localized to the N-terminal region of the hormone-binding domain.	ros	50-53	vitamin D receptor	Rattus norvegicus	0-18
30352833-7	2018	Moreover, ROS generation and caspase-3/caspase-9 activities increased in UHRF1 knockdown cells.	ros	10-13	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	73-78
30352833-9	2018	These findings indicated that UHRF1 promoted the growth, migration and invasion of MGC803 and SGC7901 cells and inhibited apoptosis via a ROS-associated pathway.	ros	138-141	ubiquitin like with PHD and ring finger domains 1	Homo sapiens	30-35
2164926-4	1990	Therefore, the present study examined the effect of PTH on VDR regulation in vitro in ROS 17/2.8 cells and in vivo in male Holtzman rats.	ros	86-89	vitamin D receptor	Rattus norvegicus	59-62
30538220-6	2018	GPx1 degradation caused by glucose deprivation led to further ROS-dependent autophagy activation.	ros	62-65	glutathione peroxidase 1	Homo sapiens	0-4
30261287-11	2018	Silencing TXNIP or ROS scavenger restored the high glucose induced reduction of Wnt/beta-catenin activity in HUVECs.	ros	19-22	catenin (cadherin associated protein), beta 1	Mus musculus	84-96
2164926-5	1990	Treatment of ROS cells with PTH (0-5 nM) resulted in a dose and time-dependent decline in VDR from 95 +/- 9 to 35 +/- 5 fmol/mg protein at 18 h of exposure.	ros	13-16	vitamin D receptor	Rattus norvegicus	90-93
30391882-0	2018	Vitamin E inhibits cyclosporin A-induced CTGF and TIMP-1 expression by repressing ROS-mediated activation of TGF-beta/Smad signaling pathway in rat liver.	ros	82-85	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	50-56
2164926-10	1990	In accompanying experiments, 1,25(OH)2[3H]D3 treatment of ROS cells was shown to result in a 3- to 4-fold increased expression of VDR and VDR mRNA.	ros	58-61	vitamin D receptor	Rattus norvegicus	130-133
2164926-10	1990	In accompanying experiments, 1,25(OH)2[3H]D3 treatment of ROS cells was shown to result in a 3- to 4-fold increased expression of VDR and VDR mRNA.	ros	58-61	vitamin D receptor	Rattus norvegicus	138-141
2325669-0	1990	Thymosin beta 4 is expressed in ROS 17/2.8 osteosarcoma cells in a regulated manner.	ros	32-35	thymosin beta 4, X-linked	Rattus norvegicus	0-15
30428894-7	2018	In addition, the proBDNF of AD patients is modified by ROS-derived advanced glycation end products, which prevent the processing of the proBDNF to the mature BDNF, leading to an increase of pathogenicity and a decrease of trophic effects.	ros	55-58	brain derived neurotrophic factor	Homo sapiens	20-24
30428894-10	2018	Induction of apoptosis and p75 ICD internalization by AD patients-derived proBDNF is further enhanced in neuron cultures from the AD model expressing the APP/PS1 E9 transgene.Our results indicate the importance of proBDNF neurotoxic signaling in AD pathology essentially by three mechanisms: i) by an increase of proBDNF stability due to ROS-induced post-traductional modifications; ii) by the increase of expression of the p75 co-receptor, Sortilin and iii) by the increase of the basal levels of p75 processing found in AD.	ros	338-341	TNF receptor superfamily member 1B	Homo sapiens	27-30
2325669-2	1990	Thymosin beta 4 cDNA was cloned from an ROS 17/2.8 complimentary DAN library on the basis of its differential hybridization with radiolabeled cDNA prepared from ROS 17/2.8 and ROS 25/1 cells.	ros	40-43	thymosin beta 4, X-linked	Rattus norvegicus	0-15
2325669-2	1990	Thymosin beta 4 cDNA was cloned from an ROS 17/2.8 complimentary DAN library on the basis of its differential hybridization with radiolabeled cDNA prepared from ROS 17/2.8 and ROS 25/1 cells.	ros	161-164	thymosin beta 4, X-linked	Rattus norvegicus	0-15
2325669-2	1990	Thymosin beta 4 cDNA was cloned from an ROS 17/2.8 complimentary DAN library on the basis of its differential hybridization with radiolabeled cDNA prepared from ROS 17/2.8 and ROS 25/1 cells.	ros	161-164	thymosin beta 4, X-linked	Rattus norvegicus	0-15
2325669-8	1990	The phenotype-dependent expression in the ROS cells and the response to steroid hormone suggest that thymosin beta 4 expression contributes to the osteoblast phenotype.	ros	42-45	thymosin beta 4, X-linked	Rattus norvegicus	101-116
29958907-7	2018	Furthermore, the intracellular ROS and apoptosis ratio were determined, the results showed that ROS and apoptosis level significantly increased after OGD/R, H2 and RAP effectively restrained the increment of ROS level and apoptosis ratio but their protective effect can be weakened by 3-MA.	ros	31-34	LDL receptor related protein associated protein 1	Rattus norvegicus	150-167
33775773-2	2021	Massive ROS production can induce cell death or activate protective pathways such as Keap1/Nrf2 pathway, which regulates intracellular cysteine availability through upregulation of SLC7A11, a subunit of xCT transporter, and subsequently glutathione synthesis, thus improving antioxidative defense.	ros	8-11	solute carrier family 7 member 11	Homo sapiens	181-188
29958907-7	2018	Furthermore, the intracellular ROS and apoptosis ratio were determined, the results showed that ROS and apoptosis level significantly increased after OGD/R, H2 and RAP effectively restrained the increment of ROS level and apoptosis ratio but their protective effect can be weakened by 3-MA.	ros	96-99	LDL receptor related protein associated protein 1	Rattus norvegicus	150-167
29958907-7	2018	Furthermore, the intracellular ROS and apoptosis ratio were determined, the results showed that ROS and apoptosis level significantly increased after OGD/R, H2 and RAP effectively restrained the increment of ROS level and apoptosis ratio but their protective effect can be weakened by 3-MA.	ros	96-99	LDL receptor related protein associated protein 1	Rattus norvegicus	150-167
33777223-10	2021	However, compared with trastuzumab plus pertuzumab, H2-18 plus trastuzumab effectively activated ROS production and the phosphorylation of JNK and c-jun in NCI-N87-TraRT cells.	ros	97-100	sphingosine-1-phosphate receptor 2	Homo sapiens	52-57
30314897-8	2018	Moreover, through in-vitro functional studies, we showed that differences in GLUD2 expression level affected cell proliferation, migration, invasion, colony formation abilities, cell cycle phases, mitochondrial function and ROS production.	ros	224-227	glutamate dehydrogenase 2	Homo sapiens	77-82
33803290-0	2021	Growth Arrest-Specific Gene 6 Administration Ameliorates Sepsis-Induced Organ Damage in Mice and Reduces ROS Formation In Vitro.	ros	105-108	growth arrest specific 6	Mus musculus	0-29
30259128-9	2018	The oncogenic mechanism involves a ROS-activated AKT/FOXO1/TWIST1 signaling pathway.	ros	35-38	twist basic helix-loop-helix transcription factor 1	Mus musculus	59-65
34896222-0	2022	AMPK/PPAR-gamma/NF-kappaB axis participates in ROS-mediated apoptosis and autophagy caused by cadmium in pig liver.	ros	47-50	peroxisome proliferator activated receptor gamma	Sus scrofa	5-15
29908908-0	2018	Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.	ros	110-113	myocardin related transcription factor A	Mus musculus	0-40
29908908-0	2018	Myocardin-related transcription factor A (MRTF-A) contributes to acute kidney injury by regulating macrophage ROS production.	ros	110-113	myocardin related transcription factor A	Mus musculus	42-48
34822966-7	2022	The Cat/Re@PLGA@UCM NPs also exhibited outstanding ROS scavenging properties, downregulating ICAM-1, TNF-alpha and IL-1beta, while preventing angiogenesis to attenuate the progression of AS.	ros	51-54	interleukin 1 alpha	Homo sapiens	115-123
29960166-0	2018	ROS mediated ER stress induces Bax-Bak dependent and independent apoptosis in response to Thioridazine.	ros	0-3	BCL2 antagonist/killer 1	Homo sapiens	35-38
29960166-7	2018	ER stress and apoptosis caused by TDZ were prevented by ROS inhibitor N-acetyl-L-cysteine (NAC) and protein synthesis inhibitor cycloheximide.	ros	56-59	X-linked Kx blood group	Homo sapiens	91-94
34626772-8	2022	Although GPX4 protected UVB-injured keratinocytes against ferroptotic cell death resulted from dysregulation of iron metabolism and the subsequent increase of lipid ROS, keratinocytes enduring constant UVB treatment were markedly sensitized to ferroptosis.	ros	165-168	glutathione peroxidase 4	Mus musculus	9-13
29960166-10	2018	Studies in Bax-Bak knock-out cell model indicated that TDZ trigger both the Bax-Bak dependent and independent apoptosis through ROS.	ros	128-131	BCL2 antagonist/killer 1	Homo sapiens	15-18
29960166-10	2018	Studies in Bax-Bak knock-out cell model indicated that TDZ trigger both the Bax-Bak dependent and independent apoptosis through ROS.	ros	128-131	BCL2 antagonist/killer 1	Homo sapiens	80-83
29960166-12	2018	Both Bax-Bak dependent and independent apoptosis were significantly inhibited by ROS inhibitor NAC.	ros	81-84	BCL2 antagonist/killer 1	Homo sapiens	9-12
29960166-12	2018	Both Bax-Bak dependent and independent apoptosis were significantly inhibited by ROS inhibitor NAC.	ros	81-84	X-linked Kx blood group	Homo sapiens	95-98
29744878-8	2018	Individual treatment with inhibitor of NF-kappaB, ROS, and RhoA in tenocytes showed decreased protein expression of DNM2, TGF-beta1, and VEGF.	ros	50-53	dynamin 2	Homo sapiens	116-120
34843960-8	2022	In the trilogy of liver disease, high concentrations of ROS stimulate peroxidation and activate the inflammatory signal cascade, which involves signalling pathways such as MAPK/JAK-STAT/PERK/Wnt/Hipp, leading to varying degrees of cell degradation and liver damage.	ros	56-59	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	186-190
30014902-6	2018	Furthermore, the data from the treatment or transfection of miR-200a minic, Keap1 and TXNIP siRNA, Nrf2 activator and ROS inhibitor demonstrated that fructose-induced miR-200a low-expression increased Keap1 to block Nrf2 antioxidant pathway, and then enhanced ROS-driven TXNIP to activate NLRP3 inflammasome and disturb lipid metabolism-related proteins, causing inflammation and lipid deposition in BRL-3A cells.	ros	260-263	Kelch-like ECH-associated protein 1	Rattus norvegicus	201-206
34847624-0	2022	Alnustone inhibits the growth of hepatocellular carcinoma via ROS- mediated PI3K/Akt/mTOR/p70S6K axis.	ros	62-65	ribosomal protein S6 kinase B1	Homo sapiens	90-96
34847624-9	2022	The study provides evidence that alnustone is effective against HCC via ROS-mediated PI3K/Akt/mTOR/p70S6K pathway and the compound has the potential to be developed as a novel anticancer agent for the treatment of HCC clinically.	ros	72-75	mechanistic target of rapamycin kinase	Mus musculus	94-98
34965422-4	2021	Meanwhile, ROS dramatically increases PD-L1 mRNA levels through accelerating expression of the transcription factor NRF2.	ros	11-14	CD274 molecule	Homo sapiens	38-43
30214444-0	2018	ATF3 Stimulates IL-17A by Regulating Intracellular Ca2+/ROS-Dependent IL-1beta Activation During Streptococcus pneumoniae Infection.	ros	56-59	interleukin 17A	Mus musculus	16-22
34718703-0	2021	Corrigendum to: Magnesium isoglycyrrhizinate prevents cadmium-induced activation of JNK and apoptotic hepatocyte death by reversing ROS-inactivated PP2A.	ros	132-135	protein phosphatase 2 phosphatase activator	Homo sapiens	148-152
30048595-3	2018	Both of the isomers, P-1 and P-2, could be utilized as potential sensitizers for PDT not only owing to their definite constituents but predominantly due to their good absorption in the phototherapeutic window and high generation of intracellular ROS.	ros	246-249	crystallin gamma F, pseudogene	Homo sapiens	21-32
34516328-13	2021	Overexpression of CTRP6 alleviated apoptosis and suppressed production of ROS and MDA in these cells.	ros	74-77	C1q and tumor necrosis factor related protein 6	Mus musculus	18-23
30159115-3	2018	The present study is aimed at investigating the role of UCP2, a ROS negative regulator, in the neuroprotection after cholinergic insult.	ros	64-67	uncoupling protein 2	Rattus norvegicus	56-60
30048924-5	2018	The intracellular localization assay confirmed that the complex 1 was effectively distributed into mitochondria as well as endoplasmic reticulum (ER), and executed a ROS-mediated calcium and Bax/Bak dependent intrinsic apoptosis.	ros	166-169	BCL2 antagonist/killer 1	Homo sapiens	195-198
34558381-12	2021	Inhibition of TRIM22 inhibited the production of ROS in these cells.	ros	49-52	tripartite motif containing 22	Homo sapiens	14-20
29775890-4	2018	In free fatty acids-induced HepG2 cells, CPT dramatically decreased ROS content, increased mitochondrial NADH dehydrogenase (Complex I) and mitochondrial cytochrome C oxidase (Complex IV) levels.	ros	68-71	choline phosphotransferase 1	Homo sapiens	41-44
34530523-10	2021	This effect may be due to the inhibition of ROS production through MAPKs, Bax, and Bcl-2 activation, and the restoration of inflammation through NF-kappaB inhibition.	ros	44-47	BCL2 associated X, apoptosis regulator	Rattus norvegicus	74-77
34449897-10	2021	Our data suggest that MiCTL1a interacts with plant catalases and interferes with catalase activity, allowing M. incognita to establish a parasitic relationship with its host by fine-tuning ROS-mediated responses.	ros	189-192	catalase 2	Arabidopsis thaliana	81-89
29858680-13	2018	Elevation of METase activity suppressed the proliferation of CD44(+) GC cells through down-regulating MET in cellular supernatant that resulted in the increase of Cyc C and ROS levels.	ros	173-176	CD44 antigen	Mus musculus	61-65
30044838-10	2018	The results show that the activation of mGluR2 and mGluR3 a short time after H-I triggers neuroprotective mechanisms that act through the inhibition of oxidative stress and ROS production.	ros	173-176	glutamate receptor, ionotropic, AMPA3 (alpha 3)	Mus musculus	51-57
30022966-11	2018	Based on a linear regression analysis, GSTM2 and UGT2A1 were found to be the most influential genes in ROS detoxification.	ros	103-106	UDP glucuronosyltransferase 2 family, polypeptide A1	Mus musculus	49-55
34196914-6	2021	Further research showed that ANXA2 is localized on ROs and interacts with PI4KB.	ros	51-54	annexin A2	Homo sapiens	29-34
29601906-5	2018	Mechanistically, activated Syk repressed the expression and activity of mitochondrial complex I (COX-1), unfortunately evoking mitochondrial and/or cellular ROS overproduction.	ros	157-160	spleen associated tyrosine kinase	Homo sapiens	27-30
34801863-0	2021	A novel role of KEAP1/PGAM5 complex: ROS sensor for inducing mitophagy.	ros	37-40	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	22-27
29984607-12	2018	The formation of ROS and the expression of MDA5 (4.46 +- 0.01) and IREalpha (3.43 +- 0.00) mRNA and protein were increased and the expression of SOD-1 (0.28 +- 0.02) mRNA and protein was decreased ( P &lt; 0.05).	ros	17-20	interferon induced with helicase C domain 1	Mus musculus	43-47
34801863-6	2021	We also demonstrate that inhibitors of the KEAP1-PGAM5 protein-protein interaction (including CPUY192018) mimic the effect of mitochondrial ROS and sensitize mitophagy machinery, suggesting that these inhibitors could be used as pharmacological regulators of mitophagy.	ros	140-143	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	49-54
34509754-8	2021	The productions of ROS, NO, and GBP2 were significantly reduced in TLR2-/- and TLR3-/- mouse macrophages.	ros	19-22	toll-like receptor 3	Mus musculus	79-83
28605990-10	2018	miR-25 protected PC-12 cells against H2O2-induced oxidative damage, as evidenced by significant suppression in cell apoptosis, increase in cell viability, decrease in the level of ROS, HIF-alpha and gammaH2A, and decrease in inflammatory mediators (IL-1beta, TNF-alpha, IL-6, and MCP-1).	ros	180-183	microRNA 25	Rattus norvegicus	0-6
34537329-6	2021	In Parkinson"s disease, increased platelet alpha-synuclein is associated with elevated ROS production and mitochondrial dysfunction.	ros	87-90	synuclein alpha	Homo sapiens	43-58
29857913-14	2018	Because both T cell activation and LTP are dependent on intracellular Ca2+ increases and because inhibition of ROS significantly inhibits hippocampal CA1 LTP and T cell activation, it is our hypothesis that AMPK links latent HIV-1 reactivation with hippocampal LTP, learning, and memory.	ros	111-114	carbonic anhydrase 1	Homo sapiens	150-153
34688156-5	2021	Especially for malignant diseases, there may be new advances in the treatment of HO-1 by regulating abnormal ROS and metabolic signaling.	ros	109-112	heme oxygenase 1	Homo sapiens	81-85
29760122-8	2018	Disrupted mitochondrial dynamics and enhanced Mfn1-Bak interactions modulated by p66Shc led to loss of mitochondrial voltage potential, cytochrome C release, excessive ROS generation, and apoptosis.	ros	168-171	mitofusin 1	Homo sapiens	46-50
29760122-8	2018	Disrupted mitochondrial dynamics and enhanced Mfn1-Bak interactions modulated by p66Shc led to loss of mitochondrial voltage potential, cytochrome C release, excessive ROS generation, and apoptosis.	ros	168-171	BCL2 antagonist/killer 1	Homo sapiens	51-54
29571736-9	2018	Our results uncovered the anti-pyroptosis role of liraglutide in TNF-alpha and hypoxia-stimulated H9c2 cells, which was associated with SIRT1/NOX4/ROS pathway.	ros	147-150	NADPH oxidase 4	Rattus norvegicus	142-146
34238903-0	2021	FUNDC1 Regulates Autophagy by Inhibiting ROS-NLRP3 Signaling to Avoid Apoptosis in the Lung In A Lipopolysaccharide-Induced Mouse Model.	ros	41-44	NLR family, pyrin domain containing 3	Mus musculus	45-50
34238903-4	2021	This study explored whether FUNDC1 regulates autophagy by inhibiting ROS-NLRP3 signaling to avoid apoptosis in the lung in a lipopolysaccharide-induced mouse model.	ros	69-72	NLR family, pyrin domain containing 3	Mus musculus	73-78
34777396-6	2021	Furthermore, we identified CD38 as an inflammatory mediator of exhausted monocytes, associated with a drastic depletion of cellular NAD+; elevation of ROS; and compromise of mitochondria respiration, representative of septic monocytes.	ros	151-154	CD38 molecule	Homo sapiens	27-31
34737608-9	2021	Moreover, decreased expression of TEAD2 could induce the ferroptosis through increasing the ROS accumulation.	ros	92-95	TEA domain transcription factor 2	Homo sapiens	34-39
29388468-7	2018	Exogenous ROS, hydrogen peroxide (H2O2), increases PLCgamma1 phosphorylation at tyrosine-783 and IP3 production.	ros	10-13	phospholipase C, gamma 1	Mus musculus	51-60
29388468-11	2018	In conclusion, acute hypoxia uniquely causes ROS-dependent PLCgamma1 activation, IP3 production, PKCepsilon activation, IP3R1 opening, Ca2+ release, and contraction in mouse PASMCs; CH enhances PASM PLCgamma1 expression, activity, and function, playing an essential role in pulmonary hypertension in mice.	ros	45-48	phospholipase C, gamma 1	Mus musculus	59-68
34675216-5	2021	SIRT3 knockdown significantly increased the expression of HSP70, Bax, and cleaved-caspase 3 and inhibited the production of antioxidases, thus promoting ROS production and cell apoptosis in BMECs.	ros	153-156	sirtuin 3	Bos taurus	0-5
29211299-8	2018	ROS level and activity of arginase of LOX-1 + CD15+ PMN were higher in LOX-1+  CD15+ PMN-MDSCs than LOX-1-  CD15+ PMNs, as well as the expression of the NADPH oxidase NOX2 and arginase I. RNA sequence revealed that LOX-1+ CD15+ PMN-MDSCs displayed significantly higher expression of spliced X-box -binding protein 1 (sXBP1), an endoplasmic reticulum (ER) stress marker.	ros	0-3	cytochrome b-245 beta chain	Homo sapiens	167-171
34452699-0	2021	Role of the TRPM4 channel in mitochondrial function, calcium release, and ROS generation in oxidative stress.	ros	74-77	transient receptor potential cation channel subfamily M member 4	Homo sapiens	12-17
29576081-0	2018	SELENOPROTEIN O is a chloroplast protein involved in ROS scavenging and its absence increases dehydration tolerance in Arabidopsis thaliana.	ros	53-56	selenoprotein O	Arabidopsis thaliana	0-15
29576081-8	2018	Enhanced expression of genes encoding ROS scavenging enzymes in the unstressed selo mutant correlated with higher oxidant scavenging capacity and reduced methyl viologen damage.	ros	38-41	selenoprotein O	Arabidopsis thaliana	79-83
29576081-9	2018	The study elucidates SELO as a PSI-related component involved in regulating ROS levels and stress responses.	ros	76-79	selenoprotein O	Arabidopsis thaliana	21-25
34681889-6	2021	Irisin caused an increase in the levels of anti-apoptotic BCL2 to pro-apoptotic BAX and reduced ROS levels in an in vitro model of placental ischemia.	ros	96-99	fibronectin type III domain containing 5	Homo sapiens	0-6
29175054-6	2018	However, CD163- cells tended to produce higher levels of ROS in response to PMA, whereas CD163+ cells were more efficient in endocytosing and processing antigens (DQ-OVA).	ros	57-60	CD163 molecule	Homo sapiens	9-14
29421327-7	2018	Intracellular ROS accumulation arouses ER stress, initiating PERK dependent UPR and inducing the downstream signal Nrf2 and ATF4 auto-phosphorylation.	ros	14-17	activating transcription factor 4	Homo sapiens	124-128
34652584-10	2022	CONCLUSION: Astaxanthin can protect the kidney in CI-AKI by inhibiting the activation of NLRP3 inflammasome-IL-1beta/IL-18 through inhibition of the production of ROS.	ros	163-166	interleukin 18	Rattus norvegicus	117-122
34681736-5	2021	ROS-induced endoplasmic reticulum (ER) stress by OSMI-1 not only upregulated CHOP-DR5 signaling but also activated Jun-N-terminal kinase (JNK), resulting in a decrease in Bcl2 and the release of cytochrome c from mitochondria.	ros	0-3	TNF receptor superfamily member 10b	Homo sapiens	82-85
29297728-3	2018	CONCLUSIONS: Evidence for involvement of the alpha-synuclein, cytochrome c oxidase, alphaB-crystallin, RNase L, and lactate dehydrogenase/STAT1 pathways is strong and suggests a common underlying mechanism involving mitochondrial dysfunction mediated by ROS and disruption of ATP production.	ros	254-257	signal transducer and activator of transcription 1	Homo sapiens	138-143
34692691-0	2021	TEOA Promotes Autophagic Cell Death via ROS-Mediated Inhibition of mTOR/p70S6k Signaling Pathway in Pancreatic Cancer Cells.	ros	40-43	ribosomal protein S6 kinase B1	Homo sapiens	72-78
29363860-0	2018	ACE2-EPC-EXs protect ageing ECs against hypoxia/reoxygenation-induced injury through the miR-18a/Nox2/ROS pathway.	ros	102-105	cytochrome b-245 beta chain	Homo sapiens	97-101
34692691-8	2021	Notably, our further experiments showed that TEOA induced autophagic cell death in pancreatic ductal adenocarcinoma cells by inactivating the ROS-dependent mTOR/p70S6k signaling pathway.	ros	142-145	ribosomal protein S6 kinase B1	Homo sapiens	161-167
29363860-7	2018	These data suggest that ACE-EPCs-EXs have better protective effects on H/R injury in ageing ECs which could be through their carried miR-18a and subsequently down-regulating the Nox2/ROS pathway.	ros	183-186	cytochrome b-245 beta chain	Homo sapiens	178-182
34363021-6	2021	Comparatively, ITLN1-derived MDSCs had a lower suppressive effect on T cell proliferation, NOS2 expression, and ROS production.	ros	112-115	intelectin 1	Homo sapiens	15-20
29216538-6	2018	We found that the TIP60 inhibition impaired embryonic development by ROS induced DNA damage, as demonstrated by the number of gammaH2A in the nuclei.	ros	69-72	lysine acetyltransferase 5	Homo sapiens	18-23
34310992-5	2021	The upregulation of NOX4 expression promoted ROS-mediated p38 MAPK phosphorylation, leading to protein phosphatase 2A (PP2A)-regulated tristetraprolin (TTP) degradation.	ros	45-48	protein phosphatase 2 phosphatase activator	Homo sapiens	103-117
29854032-7	2018	The inhibiter of methyltransferase EZH2, EPZ005687 significantly inhibits the development of TAC-induced PAH in an EZH2-SOD1-ROS dependent manner.	ros	125-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	35-39
34310992-5	2021	The upregulation of NOX4 expression promoted ROS-mediated p38 MAPK phosphorylation, leading to protein phosphatase 2A (PP2A)-regulated tristetraprolin (TTP) degradation.	ros	45-48	protein phosphatase 2 phosphatase activator	Homo sapiens	119-123
29854032-7	2018	The inhibiter of methyltransferase EZH2, EPZ005687 significantly inhibits the development of TAC-induced PAH in an EZH2-SOD1-ROS dependent manner.	ros	125-128	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	115-119
34572050-3	2021	Subcellular traffics of HO-1 to different organelles constitute a network of interactions compromising a variety of effectors such as pro-oxidants, ROS, mitochondrial enzymes, and nucleic transcription factors.	ros	148-151	heme oxygenase 1	Homo sapiens	24-28
34287039-5	2021	Here, we demonstrate that PCV2 infection increased expression of ERO1alpha, generation of ROS and nucleocytoplasmic migration of HMGB1 via PERK activation in PK-15 cells.	ros	90-93	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	139-143
29459657-4	2018	Experiments using the NOX2-specific inhibitor Phox-I2 suggest that NOX2 is activated by accumulating long-chain fatty acids and generates ROS, which in turn changes mitochondrial morphology and activity.	ros	138-141	cytochrome b-245 beta chain	Homo sapiens	22-26
29459657-4	2018	Experiments using the NOX2-specific inhibitor Phox-I2 suggest that NOX2 is activated by accumulating long-chain fatty acids and generates ROS, which in turn changes mitochondrial morphology and activity.	ros	138-141	cytochrome b-245 beta chain	Homo sapiens	67-71
34287039-6	2021	Inhibition of PERK or ERO1alpha repressed ROS production in PCV2-infected cells and increased HMGB1 retention within nuclei.	ros	42-45	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	14-18
34287039-7	2021	These findings indicate that PCV2-induced activation of the PERK-ERO1alpha axis would lead to enhanced generation of ROS sufficient to decrease HMGB1 retention in the nuclei, thus derepressing viral DNA from HMGB1 sequestration.	ros	117-120	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	60-64
34287039-8	2021	The viral Rep and Cap proteins were able to induce PERK-ERO1alpha-mediated ROS accumulation.	ros	75-78	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	51-55
34489530-6	2021	Deletion of SDHD (Succinate dehydrogenase) gene from the complex II in the Substantia Nigra of Thy1-C/EBPbeta mice triggers ROS and PD pathologies, resulting in motor disorders.	ros	124-127	succinate dehydrogenase complex, subunit D, integral membrane protein	Mus musculus	18-41
34564417-4	2021	Treatment with polyinosinic:polycytidylic acid (poly(I:C))-an agonist of TLR3-significantly suppressed intracellular bacterial growth by promoting intracellular ROS production in S. Typhimurium-infected cells.	ros	161-164	toll-like receptor 3	Mus musculus	73-77
29556358-13	2018	ROS stress and DNA damage marker gammaH2AX were enhanced by siPHGDH and NCT-503, which was reversed by NAC.	ros	0-3	X-linked Kx blood group	Homo sapiens	103-106
29195919-4	2018	Phosphorylation of p47phox subunit occurs in both short spurts as well as sustained ROS generation, suggesting towards the unidentified molecular mechanism(s) driving these two diverse outcomes by various stimuli.	ros	84-87	neutrophil cytosolic factor 1	Homo sapiens	19-26
18418700-12	2008	Thus, in the embryonic heart, JNK activity exhibits a characteristic pattern during anoxia and reoxygenation and the respective open-state of LCC, MCU and mitoKATP channel can be a major determinant of JNK activity in a ROS-independent manner.	ros	220-223	mitochondrial calcium uniporter	Gallus gallus	147-150
18348865-5	2008	Thus, the choice between modification of PLZF by SUMO or ubiquitin was determined by the intracellular level of ROS, which was generated by serum deprivation that inactivated the SUMO-conjugating enzymes Uba2 and Ubc9, and resulted in decrease of sumoylation.	ros	112-115	zinc finger and BTB domain containing 16	Homo sapiens	41-45
29195919-5	2018	The present study demonstrates that in PMA or NO treated neutrophils a subunit of NOX2, p47phox gets glutathionylated to sustain ROS generation along with a decrease in catalase, Grx-1 activity and change in GSH/GSSG ratio.	ros	129-132	cytochrome b-245 beta chain	Homo sapiens	82-86
34332981-11	2021	Antioxidant NAC could alleviate the synergetic effects of DCA and sorafenib on ROS generation, JNK activation, Mcl-1 degradation, and cell apoptosis.	ros	79-82	synuclein alpha	Homo sapiens	12-15
29195919-5	2018	The present study demonstrates that in PMA or NO treated neutrophils a subunit of NOX2, p47phox gets glutathionylated to sustain ROS generation along with a decrease in catalase, Grx-1 activity and change in GSH/GSSG ratio.	ros	129-132	neutrophil cytosolic factor 1	Homo sapiens	88-95
29195919-8	2018	Interestingly, forced S-glutathionylation of p47phox converted the fMLP induced ROS generation into sustained release of ROS.	ros	80-83	neutrophil cytosolic factor 1	Homo sapiens	45-52
29195919-8	2018	Interestingly, forced S-glutathionylation of p47phox converted the fMLP induced ROS generation into sustained release of ROS.	ros	121-124	neutrophil cytosolic factor 1	Homo sapiens	45-52
18348865-8	2008	On the basis of these results, we propose that PLZF post-translational modification is controlled by intracellular ROS, and the biological function of PLZF is regulated by sumoylation and ubiquitination.	ros	115-118	zinc finger and BTB domain containing 16	Homo sapiens	47-51
18202147-1	2008	The effects of the expression of the Na+/H+ exchanger regulatory factor-1 (NHERF1) on the distribution, dynamics, and signaling properties of the PTH type 1 receptor (PTH1R) were studied in rat osteosarcoma cells ROS 17/2.8.	ros	213-216	parathyroid hormone 1 receptor	Rattus norvegicus	146-165
34574108-5	2021	Notably, we detected varied impacts of different ROS scavengers (catalase > thiourea > superoxide dismutase) during light application, suggesting that hydrogen peroxide (H2O2), the reducing target of catalase, has a key role during blue light inactivation.	ros	49-52	catalase HPII	Cronobacter sakazakii	65-73
18262205-7	2008	Thus, HO-1 and the HO-1 product CO play, at least in part, a crucial role in Ang II-stimulated VSMC proliferation through the regulation of ROS production and JNK phosphorylation.	ros	140-143	heme oxygenase 1	Rattus norvegicus	19-23
18262205-7	2008	Thus, HO-1 and the HO-1 product CO play, at least in part, a crucial role in Ang II-stimulated VSMC proliferation through the regulation of ROS production and JNK phosphorylation.	ros	140-143	angiogenin	Rattus norvegicus	77-80
29284135-5	2018	MUD1 exerted also anticancer activity on HepG2 cells, by reducing cellular viability, increasing intracellular ROS levels and affecting mitochondrial functionality in a dose-dependent manner.	ros	111-114	small nuclear ribonucleoprotein polypeptide A	Homo sapiens	0-4
34574108-5	2021	Notably, we detected varied impacts of different ROS scavengers (catalase > thiourea > superoxide dismutase) during light application, suggesting that hydrogen peroxide (H2O2), the reducing target of catalase, has a key role during blue light inactivation.	ros	49-52	catalase HPII	Cronobacter sakazakii	200-208
34492839-10	2021	NAC attenuated CuSO4-induced ROS production, inhibited apoptosis and DNA damage.	ros	29-32	synuclein alpha	Homo sapiens	0-3
28689792-12	2018	Mast cells from ROS-resistant CaMKII MMVVdelta mice or pretreated with CaMKII inhibitor showed protection against KYN-promoted OVA-induced mast cell activation.	ros	16-19	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	30-36
28689792-12	2018	Mast cells from ROS-resistant CaMKII MMVVdelta mice or pretreated with CaMKII inhibitor showed protection against KYN-promoted OVA-induced mast cell activation.	ros	16-19	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	71-77
29552311-9	2018	We therefore demonstrated that miR-29b reverses oxaliplatin-resistance in colorectal cancer by targeting SIRT1/ROS/JNK pathway.	ros	111-114	sirtuin 1	Homo sapiens	105-110
18551189-3	2008	Here, we report that mutations of MCD1 and PDS5, two major components of cohesin in budding yeast, cause apoptotic cell death, which is characterized by externalization of phosphatidylserine at cytoplasmic membrane, chromatin condensation and fragmentation, and ROS production.	ros	262-265	Pds5p	Saccharomyces cerevisiae S288C	43-47
34483935-7	2021	We found that PHP-PDT can up-regulate xCT expression to promote cells against overloaded ROS, while SASP reduces GSH levels.	ros	89-92	solute carrier family 7 member 11	Homo sapiens	38-41
17920533-0	2007	Heme oxygenase-1 induction by (S)-enantiomer of YS-51 (YS-51S), a synthetic isoquinoline alkaloid, inhibits nitric oxide production and nuclear factor-kappaB translocation in ROS 17/2.8 cells activated with inflammatory stimulants.	ros	175-178	heme oxygenase 1	Rattus norvegicus	0-16
29386120-4	2018	ERF115, ERF114, and ERF109 mediate ROS signaling, in a PLT-independent manner, to control root stem cell niche maintenance and root growth through phytosulfokine (PSK) peptide hormones in Arabidopsis.	ros	35-38	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	0-6
18230302-3	2007	RESULTS: NEP could improve the viability of cells and the production of ATP, inhibit the release of LDH and ROS.	ros	108-111	membrane metallo-endopeptidase	Rattus norvegicus	9-12
34349235-10	2022	Furthermore, in cardiomyocytes, ISO increased the efflux of potassium and the generation of ROS, which are recognized as activators of the NLRP3 inflammasome.	ros	92-95	NLR family, pyrin domain containing 3	Mus musculus	139-144
29122608-8	2018	Moreover, HSA-Trx markedly suppressed Cu2+/Zn2+-induced ROS production and the expression of oxidative stress related genes, such as heme oxygenase-1.	ros	56-59	thioredoxin 1	Mus musculus	14-17
29122608-11	2018	These results suggest that HSA-Trx counteracted Cu2+/Zn2+-induced neurotoxicity by suppressing the production of ROS via interfering the related gene expressions, in addition to the highly possible radical scavenging activity of the fusion protein.	ros	113-116	thioredoxin 1	Mus musculus	31-34
34440751-8	2021	ROS/RNS-induced reductions in TrkA expression reduce cell viability, as proNGF loses its neurotrophic function in the absence of TrkA and instead generates apoptotic signalling via the pan-neurotrophin receptor p75NTR.	ros	0-3	nerve growth factor receptor	Homo sapiens	211-217
17886033-1	2007	The involvement of mitochondrial glycerophosphate dehydrogenase (mGPDH) has previously been established in the production of ROS in prostate cancer cell lines (LNCaP, DU145, PC3 and CL1).	ros	125-128	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	65-70
17886033-1	2007	The involvement of mitochondrial glycerophosphate dehydrogenase (mGPDH) has previously been established in the production of ROS in prostate cancer cell lines (LNCaP, DU145, PC3 and CL1).	ros	125-128	proprotein convertase subtilisin/kexin type 1	Mus musculus	174-177
30109811-2	2018	Based on our finding that the p66 isoform of SHC1 (p66SHC) pro-apoptotic ROS-elevating SHC family adaptor inhibits MTOR signaling in these cells, here we investigated the role of p66SHC in B-cell autophagy.	ros	73-76	SHC adaptor protein 1	Homo sapiens	45-48
17886033-7	2007	These data suggest that the up-regulation of mGPDH, due to a highly glycolytic environment, contributes to the overall increase in ROS generation and may result in the progression of the cancer.	ros	131-134	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	45-50
34130142-0	2021	Tumor progress intercept by intervening in Caveolin-1 related intercellular communication via ROS-sensitive c-Myc targeting therapy.	ros	94-97	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
29158087-0	2018	FABP4 induces asthmatic airway epithelial barrier dysfunction via ROS-activated FoxM1.	ros	66-69	forkhead box M1	Mus musculus	80-85
29158087-13	2018	Upregulated ROS induced by FABP4 was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.	ros	12-15	forkhead box M1	Mus musculus	67-72
34310342-8	2021	Ultimately, GAS6-rescued MII oocytes exhibited increased ATP levels, reduced ROS levels and elevated glutathione (GSH) levels, collectively indicating improved mitochondrial function in aged oocytes.	ros	77-80	growth arrest specific 6	Mus musculus	12-16
30032136-14	2018	The metformin/FTY720 regimen markedly induced ROS generation; moreover, apoptosis, ER stress and inhibition of PI3K/AKT/ mTOR were attenuated by the ROS scavenger NAC.	ros	46-49	X-linked Kx blood group	Homo sapiens	163-166
30032136-14	2018	The metformin/FTY720 regimen markedly induced ROS generation; moreover, apoptosis, ER stress and inhibition of PI3K/AKT/ mTOR were attenuated by the ROS scavenger NAC.	ros	149-152	X-linked Kx blood group	Homo sapiens	163-166
30384364-14	2018	In vitro, up-regulation Trx resulted in decreased intracellular ROS generation, reduced apoptosis by inhibited autophagy.	ros	64-67	thioredoxin 1	Mus musculus	24-27
28549109-6	2018	Further investigation revealed that the rapid inflammasome-dependent activation of IL-18, but not IL-1beta, was the critical up-stream regulator for elevated chemokine expression in the myocardium upon ISO induced beta1-AR-ROS signalling.	ros	223-226	interleukin 18	Homo sapiens	83-88
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	ros	33-36	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	41-49
28935635-9	2018	The molecular link between iron, ROS and SerpinB3 seems to be HIF-2alpha, which is induced by iron overload and was previously found capable of up-regulating SerpinB3 at the transcriptional level.	ros	33-36	serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D	Mus musculus	158-166
29383185-0	2017	GPER-independent inhibition of adrenocortical cancer growth by G-1 involves ROS/Egr-1/BAX pathway.	ros	76-79	G protein-coupled estrogen receptor 1	Homo sapiens	0-4
28606754-4	2017	Decreased intracellular acetic acid, ROS accumulation, and plasma membrane permeability were observed in the ADY2 deletion mutant.	ros	37-40	Ady2p	Saccharomyces cerevisiae S288C	109-113
28836394-5	2017	Results showed that 4-TBP or HQ treatment increased apoptosis and the expression levels of TNF-alpha, IL-1alpha, and ROS in PI3K-knockdown keratinocytes which reduced Nrf2 nuclear translocation compared to control keratinocytes.	ros	117-120	TATA-box binding protein	Homo sapiens	22-25
29234670-3	2017	Here we show that heterologous expression of human or Drosophila spartin extends chronological lifespan of yeast, reducing age-associated ROS production, apoptosis, and necrosis.	ros	138-141	spartin	Drosophila melanogaster	65-72
29312589-7	2017	Enhanced ROS generation rescued the p-STAT3 and CyclinD1 expression reduction in G6PD-knockdown cells, while ROS scavengers reversed the up-regulated p-STAT3 and CyclinD1 expression in G6PD-overexpressing cells.	ros	9-12	glucose-6-phosphate dehydrogenase	Homo sapiens	81-85
29312589-7	2017	Enhanced ROS generation rescued the p-STAT3 and CyclinD1 expression reduction in G6PD-knockdown cells, while ROS scavengers reversed the up-regulated p-STAT3 and CyclinD1 expression in G6PD-overexpressing cells.	ros	109-112	glucose-6-phosphate dehydrogenase	Homo sapiens	185-189
29117557-4	2017	We discovered that knockdown of the mTOR-independent factor Eif6, which we predicted to be a key regulator of this process, affects mitochondrial respiration efficiency, ROS production, and exercise performance.	ros	170-173	eukaryotic translation initiation factor 6	Homo sapiens	60-64
28774732-8	2017	Moreover, PB-induced apoptosis and autophagosome formation were linked to the generation of intracellular ROS, and pre-treatment with the antioxidant NAC obviously mitigated the effects.	ros	106-109	X-linked Kx blood group	Homo sapiens	150-153
28665927-6	2017	In agreement with this, overexpression of p66shc or knockdown of Nrf2/MnSOD augmented nicotine-induced ROS production in renal proximal tubule cells.ConclusionChronic nicotine exposure incites higher oxidative stress in the adolescent than in adult kidney because of a pre-existent pro-oxidant milieu.	ros	103-106	src homology 2 domain-containing transforming protein C1	Mus musculus	42-48
28609580-4	2017	Meanwhile, a pool of NADPH-the reductive engine of many ROS-combating enzymes-is maintained by metabolic enzymes including, but not exclusively, glucose-6 phosphate dehydrogenase (G6PDH) and NADP-dependent isocitrate dehydrogenase (ICDH-NADP).	ros	56-59	glucose-6-phosphate dehydrogenase	Homo sapiens	145-178
28609580-4	2017	Meanwhile, a pool of NADPH-the reductive engine of many ROS-combating enzymes-is maintained by metabolic enzymes including, but not exclusively, glucose-6 phosphate dehydrogenase (G6PDH) and NADP-dependent isocitrate dehydrogenase (ICDH-NADP).	ros	56-59	glucose-6-phosphate dehydrogenase	Homo sapiens	180-185
28806703-8	2017	Combined treatment with curcumin and thioridazine produced intracellular ROS in a NOX4-dependent manner, and ROS-mediated activation of Nrf2/ARE signaling played a critical role in the up-regulation of PSMA5 expression.	ros	73-76	proteasome 20S subunit alpha 5	Homo sapiens	202-207
28806703-8	2017	Combined treatment with curcumin and thioridazine produced intracellular ROS in a NOX4-dependent manner, and ROS-mediated activation of Nrf2/ARE signaling played a critical role in the up-regulation of PSMA5 expression.	ros	109-112	proteasome 20S subunit alpha 5	Homo sapiens	202-207
29416738-8	2018	Instead, PARP-1 inhibition promotes APR-246-facilitated inactivation of thioredoxin reductase 1 (TrxR1), leading to ROS accumulation and DNA damage.	ros	116-119	thioredoxin reductase 1	Homo sapiens	72-95
29416738-8	2018	Instead, PARP-1 inhibition promotes APR-246-facilitated inactivation of thioredoxin reductase 1 (TrxR1), leading to ROS accumulation and DNA damage.	ros	116-119	thioredoxin reductase 1	Homo sapiens	97-102
29416738-9	2018	Overexpression of TrxR1 or application of antioxidant N-acetyl-L-cysteine (NAC) depletes the ROS increase, reduces DNA damage, and decreases cell death triggered by APR-246/PHEN in HNSCC cells.	ros	93-96	thioredoxin reductase 1	Homo sapiens	18-23
29416738-9	2018	Overexpression of TrxR1 or application of antioxidant N-acetyl-L-cysteine (NAC) depletes the ROS increase, reduces DNA damage, and decreases cell death triggered by APR-246/PHEN in HNSCC cells.	ros	93-96	X-linked Kx blood group	Homo sapiens	75-78
28923043-13	2017	Inhibition of MMP-13 enhanced Ros.	ros	30-33	collagenase 3	Oryctolagus cuniculus	14-20
28712866-0	2017	Cell-free methemoglobin drives platelets to apoptosis via mitochondrial ROS-mediated activation of JNK and p38 MAP kinase.	ros	72-75	hemoglobin subunit gamma 2	Homo sapiens	10-23
28712866-5	2017	The results of this study demonstrate that MtHb, not Hb exerts oxidative stress on platelets, which triggers their death via ROS-mediated mitochondrial apoptotic pathway.	ros	125-128	hemoglobin subunit gamma 2	Homo sapiens	43-47
28812437-8	2017	ROS was elevated when autophagy was induced in GSCs and activated KDR phosphorylation through the phosphoinositide 3-kinase (PI3K)-AKT pathway.	ros	0-3	kinase insert domain receptor	Homo sapiens	66-69
28812437-9	2017	A ROS inhibitor, N-acetylcysteine, abolished KDR phosphorylation and the formation of VM by GSCs.	ros	2-5	kinase insert domain receptor	Homo sapiens	45-48
28574504-4	2017	We further demonstrate that NADPH oxidase 2 (NOX2)-dependent ROS production is upstream to ATM activation and is essential during this process.	ros	61-64	cytochrome b-245 beta chain	Homo sapiens	28-43
28574504-4	2017	We further demonstrate that NADPH oxidase 2 (NOX2)-dependent ROS production is upstream to ATM activation and is essential during this process.	ros	61-64	cytochrome b-245 beta chain	Homo sapiens	45-49
28912678-0	2017	IL-17A Enhances Microglial Response to OGD by Regulating p53 and PI3K/Akt Pathways with Involvement of ROS/HMGB1.	ros	103-106	interleukin 17A	Homo sapiens	0-6
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	33-36	interleukin 17A	Homo sapiens	66-72
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	33-36	interleukin 17A	Homo sapiens	114-120
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	91-94	interleukin 17A	Homo sapiens	66-72
28912678-6	2017	These findings demonstrated that ROS might be located upstream of IL-17A and HMGB1 so that ROS can regulate HMGB1/IL-17A expression to affect the p53 and PI3K/Akt signaling pathways and therefore promote the occurrence of apoptosis in microglial cells.	ros	91-94	interleukin 17A	Homo sapiens	114-120
28860995-0	2017	Corrigendum: Antioxidant Effect of Fructus Ligustri Lucidi Aqueous Extract in Ovariectomized Rats Is Mediated through Nox4-ROS-NF-kappaB Pathway.	ros	123-126	NADPH oxidase 4	Rattus norvegicus	118-122
28270496-2	2017	We hypothesized that alterations in intracellular ROS would trigger AML-M5 relapse by activating the intrinsic pathway.Experimental Design: We studied ROS levels and conducted c-Jun activation domain-binding protein-1 (JAB1/COPS5) and thioredoxin (TRX) gene expression analyses with blood samples obtained from 60 matched AML-M5 patients at diagnosis and relapse and conducted mechanism studies of Jab1"s regulation of Trx in leukemia cell lines.Results: Our data showed that increased production of ROS and a low capacity of antioxidant enzymes were characteristics of AML-M5, both at diagnosis and at relapse.	ros	50-53	COP9 signalosome subunit 5	Homo sapiens	219-223
28270496-9	2017	Targeting the ROS/Jab1/Trx pathway could be beneficial in the treatment of AML-M5.	ros	14-17	COP9 signalosome subunit 5	Homo sapiens	18-22
28288414-0	2017	Butyrate induces ROS-mediated apoptosis by modulating miR-22/SIRT-1 pathway in hepatic cancer cells.	ros	17-20	sirtuin 1	Homo sapiens	61-67
28694518-8	2017	Therefore, PDK1 appears to contribute to HSC function partially via regulating ROS levels.	ros	79-82	3-phosphoinositide dependent protein kinase 1	Homo sapiens	11-15
28506198-10	2017	DHBA but not Dimethoxy Benzoic Acid (DMBA) inhibited HDAC activity, leading to cancer cell growth inhibition through the induction of ROS and cellular apoptosis mediated by Caspase-3.	ros	134-137	histone deacetylase 9	Homo sapiens	53-57
28323129-0	2017	Peroxiredoxin 2 regulates PGF2alpha-induced corpus luteum regression in mice by inhibiting ROS-dependent JNK activation.	ros	91-94	mitogen-activated protein kinase 8	Mus musculus	105-108
28323129-7	2017	We found that PGF2alpha-induced ROS generation was significantly higher in Prx2-/- MEF cells compared with that in wild-type (WT) cells, which induced apoptosis by activating JNK-mediated apoptotic signaling pathway.	ros	32-35	mitogen-activated protein kinase 8	Mus musculus	175-178
28323129-11	2017	This is the first study to demonstrate that Prx2 deficiency ultimately accelerated the PGF2alpha-induced luteal regression through activation of the ROS-dependent JNK pathway.	ros	149-152	mitogen-activated protein kinase 8	Mus musculus	163-166
28323129-12	2017	These findings suggest that Prx2 plays a crucial role in preventing accelerated luteal regression via inhibition of the ROS/JNK pathway.	ros	120-123	mitogen-activated protein kinase 8	Mus musculus	124-127
17675106-7	2007	Treatment with glucose oxidase (GOX, 20 mU/ml) increased ROS production and caused apoptotic death, as assayed by DCFH-DA and TUNEL, respectively.	ros	57-60	hydroxyacid oxidase 1	Homo sapiens	15-30
17675106-7	2007	Treatment with glucose oxidase (GOX, 20 mU/ml) increased ROS production and caused apoptotic death, as assayed by DCFH-DA and TUNEL, respectively.	ros	57-60	hydroxyacid oxidase 1	Homo sapiens	32-35
17694680-1	2007	The p47phox- and Rac 1-dependent NADPH oxidase activation, ROS production, and MAPK signaling pathways play critical roles in endotoxin-enhanced TLR4 expression and TLR4 mRNA stabilization in VSMCs.	ros	59-62	neutrophil cytosolic factor 1	Homo sapiens	4-22
16516378-10	2007	However, CAPE suppressed ROS-induced DNA strand breakage more efficiently than propolin A or propolin B.	ros	25-28	structural maintenance of chromosomes 2	Homo sapiens	9-13
16814338-12	2006	These data indicate that BE possesses abilities to inhibit ROS-mediated cytotoxic effects through modulation of ERKs activation and induction of HO-1 protein expression.	ros	59-62	heme oxygenase 1	Rattus norvegicus	145-149
16814338-13	2006	The role of HO-1 in ROS-scavenging activity of BE is proposed.	ros	20-23	heme oxygenase 1	Rattus norvegicus	12-16
16902940-2	2006	Peptides based on a binding site from receptor tyrosine kinase Ros (EGLN-pY2267-MVL, 1) have recently been shown to bind to the SHP-1 N-terminal SH2 domain (N-SH2) with considerably high affinity.	ros	63-66	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	128-133
16778989-6	2006	Transfection of HL-60 cells with a mutated p47phox (S345A) inhibited GM-CSF- and TNF-alpha-induced priming of ROS production.	ros	110-113	neutrophil cytosolic factor 1	Homo sapiens	43-50
16753836-4	2006	Both H2O2 and TPA increased intracellular ROS levels, and EC-SOD inhibited ROS generation only for the case of H2O2 but not TPA.	ros	75-78	superoxide dismutase 3	Rattus norvegicus	58-64
16753836-6	2006	These results suggest that EC-SOD is related to the EGF signaling in two ways, competition for HSPG with HB-EGF and as an ROS scavenger.	ros	122-125	superoxide dismutase 3	Rattus norvegicus	27-33
16195230-6	2005	In ROS 17/2.8 and MC3T3-E1 cells that contain endogenous Runx2, AML-1/ETO, which acts as a repressor of Runx2, significantly inhibited 1,25(OH)(2)D(3) induction of OPN transcription, OPN mRNA, and protein expression.	ros	3-6	runt related transcription factor 1	Mus musculus	64-69
16087680-2	2005	Previous studies have shown that v-src stimulates basal transcription of bsp in osteosarcoma (ROS 17/2.8) cells by targeting the inverted CCAAT element (ICE) in the proximal promoter.	ros	94-97	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	35-38
15780757-9	2005	In conclusion, Nox 2 stimulates muscle differentiation downstream of the PI 3-kinase/p38 MAPK pathway by activating the NF-kappaB/iNOS pathway via ROS generation.	ros	147-150	cytochrome b-245 beta chain	Homo sapiens	15-20
15591411-2	2005	We therefore measured the activities of the Rho GTPases Rac1, RhoA, and Cdc42 during hypoxia/reoxygenation and correlated them with changes in endothelial permeability, remodeling of the actin cytoskeleton and adherens junctions, and production of ROS.	ros	248-251	Rac family small GTPase 1	Homo sapiens	56-60
15591411-6	2005	Rac1 and RhoA rapidly respond to changes in oxygen tension, and their activity depends on NADPH oxidase- and PI3 kinase-dependent production of ROS.	ros	144-147	Rac family small GTPase 1	Homo sapiens	0-4
15811836-16	2005	The induction of VEGF by ufCB acts through an ROS-dependent pathway.	ros	46-49	vascular endothelial growth factor A	Mus musculus	17-21
15780950-4	2005	RT-PCR, immunolocalisation and Western blotting studies were employed to identify and characterise FKBP12 in rat primary osteoblasts and osteoblast-like osteosarcoma ROS 17/2.8 cells.	ros	166-169	FKBP prolyl isomerase 1A	Rattus norvegicus	99-105
15780950-6	2005	The transient exposure of ROS 17/2.8 cells to H2O2 (100 microM) was found to elevate FKBP12 mRNA after 10 min and protein expression after 24 h. Both PTH (10(-9) M) and 1,25 (OH)2D3 (Vitamin D3) (10(-7) M) suppressed FKBP12 protein expression.	ros	26-29	FKBP prolyl isomerase 1A	Rattus norvegicus	85-91
15780950-6	2005	The transient exposure of ROS 17/2.8 cells to H2O2 (100 microM) was found to elevate FKBP12 mRNA after 10 min and protein expression after 24 h. Both PTH (10(-9) M) and 1,25 (OH)2D3 (Vitamin D3) (10(-7) M) suppressed FKBP12 protein expression.	ros	26-29	FKBP prolyl isomerase 1A	Rattus norvegicus	217-223
15293323-5	2004	ROS cells exhibited significant TF activity as demonstrated by the conversion of Factor X to Factor Xa.	ros	0-3	coagulation factor III, tissue factor	Rattus norvegicus	32-34
15293323-10	2004	Thus, both mechanical and chemical stimuli induce differential expression of TF activity by ROS cells cultured on Ti6Al4V, a phenomenon that may potentiate or regulate the inflammatory responses associated with the implantation of orthopedic biomaterials.	ros	92-95	coagulation factor III, tissue factor	Rattus norvegicus	77-79
15183009-7	2004	CATH.a cells were significantly protected by the addition of 5mM GSH (Mn EC50 = 200 microM) and 10mM N-acetyl cysteine (NAC) (Mn EC50 = 300 microM), therefore, indirectly identifying intracellular ROS formation as a mechanism for Mn neurotoxicity.	ros	197-200	NLR family, pyrin domain containing 1A	Mus musculus	101-124
14697204-5	2003	In cortical neurons, blocking IOGD or suppressing TRPM7 expression blocked TRPM7 currents, anoxic 45Ca2+ uptake, ROS production, and anoxic death.	ros	113-116	transient receptor potential cation channel subfamily M member 7	Homo sapiens	50-55
14614324-8	2003	Together, these findings support a model in which induction of apoptosis in Bcr/Abl+ cells by HDIs involves coordinate inactivation of the cytoprotective Raf/MEK/ERK pathway in conjunction with the ROS-dependent activation of JNK.	ros	198-201	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	76-83
12782417-0	2003	Age-associated changes in SAPK/JNK and p38 MAPK signaling in response to the generation of ROS by 3-nitropropionic acid.	ros	91-94	mitogen-activated protein kinase 8	Mus musculus	31-34
12646574-9	2003	In conclusion, we have adopted an experimental system enabling us to study the signaling pathways in cells grown under anchorage-independent conditions and have identified matrix-independent activation of PI 3-kinase and Stat3 signaling functions, as well as the PI 3-kinase-dependent increase of cyclin A-associated Cdk2 kinase activity, to be critical for the Ros-PTK-induced anchorage-independent growth.	ros	362-365	cyclin A2	Gallus gallus	297-305
12709591-11	2003	Taken together, the data demonstrate that HO-1 gene expression in rat hepatocyte cultures after A/R is upregulated by a transcriptional mechanism that may be, in part, mediated via the generation of ROS and the glutathione system.	ros	199-202	heme oxygenase 1	Rattus norvegicus	42-46
12581340-3	2003	Hydrogen peroxide, a by-product of ROS generation, is a chemical inducer of gene expression able to activate apoptosis and to promote the antioxidant response through the activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factor.	ros	35-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	224-243
12581340-3	2003	Hydrogen peroxide, a by-product of ROS generation, is a chemical inducer of gene expression able to activate apoptosis and to promote the antioxidant response through the activation of nuclear factor-kappa B (NF-kappaB) and activator protein-1 (AP-1) transcription factor.	ros	35-38	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	245-249
12193549-9	2002	Overexpression of deltaEF1 in ROS 17/2.8 cells led to an 84% decrease in osteocalcin mRNA levels relative to cells transfected with empty vector, confirming that deltaEF1 suppresses expression of the endogenous osteocalcin gene.	ros	30-33	zinc finger E-box binding homeobox 1	Rattus norvegicus	18-26
12193549-9	2002	Overexpression of deltaEF1 in ROS 17/2.8 cells led to an 84% decrease in osteocalcin mRNA levels relative to cells transfected with empty vector, confirming that deltaEF1 suppresses expression of the endogenous osteocalcin gene.	ros	30-33	zinc finger E-box binding homeobox 1	Rattus norvegicus	162-170
11948463-4	2002	Incubation of IFN-gamma-primed MonoMac-6 cells with serum-opsonized zymosan or EGP-2-directed, mouse IgG2a-opsonized, EGP-2-positive tumor cells resulted in the production of ROS and TNF-alpha and induced E-selectin and ICAM-1 expression on HUVECs.	ros	175-178	intercellular adhesion molecule 1	Homo sapiens	220-226
11704501-6	2001	Imipramine and fluoxetine, antagonists with specificity for 5-HTT, showed the highest potency to antagonize [125I]RTI-55 binding in ROS and UMR cells.	ros	132-135	huntingtin	Rattus norvegicus	62-65
11517178-6	2001	Analysis of sequential 5"-deletion mutants of the Phex promoter in ROS 17/2.8 cells revealed bimodal activity, suggesting that both positive and negative cis-acting regions may be present.	ros	67-70	phosphate regulating endopeptidase homolog, X-linked	Rattus norvegicus	50-54
11795594-7	2001	In addition, redox up-regulation of LMW-PTP is involved in intracellular delivery of antiproliferative signals, as the arrest of growth induced by cell confluence and differentiation are associated with a decrease in the steady-state levels of intracellular ROS.	ros	258-261	acid phosphatase 1	Homo sapiens	36-43
27181592-8	2017	Either attenuation of intracellular ROS with antioxidant NAC or inhibition of JNK phosphorylation with SP600125 or JNK siRNA could significantly prevent H2O2-induced parthanatos in glioma cells.	ros	36-39	X-linked Kx blood group	Homo sapiens	57-60
28661479-9	2017	Further studies showed that N-acetyl-L-cysteine (NAC), an ROS scavenger could block autophagy induced by OTA, indicating that ROS may be involved in the regulation of OTA-induced autophagy.	ros	58-61	X-linked Kx blood group	Homo sapiens	49-52
28661479-9	2017	Further studies showed that N-acetyl-L-cysteine (NAC), an ROS scavenger could block autophagy induced by OTA, indicating that ROS may be involved in the regulation of OTA-induced autophagy.	ros	126-129	X-linked Kx blood group	Homo sapiens	49-52
28661486-1	2017	c-Jun N-terminal kinase (JNK) mediates hepatotoxicity through interaction of its phospho-activated form with a mitochondrial outer membrane protein, Sh3bp5 or Sab, leading to dephosphorylation of intermembrane Src and consequent impaired mitochondrial respiration and enhanced ROS release.	ros	277-280	mitogen-activated protein kinase 8	Mus musculus	0-23
28661486-1	2017	c-Jun N-terminal kinase (JNK) mediates hepatotoxicity through interaction of its phospho-activated form with a mitochondrial outer membrane protein, Sh3bp5 or Sab, leading to dephosphorylation of intermembrane Src and consequent impaired mitochondrial respiration and enhanced ROS release.	ros	277-280	mitogen-activated protein kinase 8	Mus musculus	25-28
28661486-2	2017	ROS production from mitochondria activates MAP3 kinases, such as MLK3 and ASK1, which continue to activate a pathway to sustain JNK activation, and amplifies the toxic effect of acetaminophen (APAP) and TNF/galactosamine (TNF/GalN).	ros	0-3	mitogen-activated protein kinase 8	Mus musculus	128-131
11294632-8	2001	The mGC is ROS-GC1.	ros	11-14	solute carrier family 25 member 22	Rattus norvegicus	15-18
34216545-4	2021	We uncovered a role of c-Jun N-terminal kinase (JNK) in driving senescence as a consequence of dysfunctional mitochondria and ROS.	ros	126-129	basket	Drosophila melanogaster	23-46
11294632-10	2001	Thus, a new facet of the Ca(2+)-modulated GCAP1--ROS-GC1 signaling system, which, until now, was believed to be unique to phototransduction, has been revealed.	ros	49-52	solute carrier family 25 member 22	Rattus norvegicus	53-56
28655909-0	2017	PLK2 Plays an Essential Role in High D-Glucose-Induced Apoptosis, ROS Generation and Inflammation in Podocytes.	ros	66-69	polo like kinase 2	Mus musculus	0-4
34216545-4	2021	We uncovered a role of c-Jun N-terminal kinase (JNK) in driving senescence as a consequence of dysfunctional mitochondria and ROS.	ros	126-129	basket	Drosophila melanogaster	48-51
11283267-4	2001	Gel mobility shift analyses with nuclear extracts from ROS 17/2.8 osteoblastic cells revealed that multiple Cbfa consensus sequences are functional Cbfa DNA binding sites.	ros	55-58	Y box binding protein 1	Rattus norvegicus	148-152
34301789-7	2021	Our studies reveal an unexpected role for mitochondria downstream of NPM1c and implicate a mitochondrial/ROS/PML/TP53 senescence pathway as an effector of ActD-based therapies.	ros	105-108	PML nuclear body scaffold	Homo sapiens	109-112
11255228-3	2001	Analysis of mRNA from ROS 25/1, UMR 106 and ROS 17/2.8 cells revealed transcripts for both 11 beta-HSD type 1 (11 beta-HSD1) and type 2 (11 beta-HSD2) in all three cell lines.	ros	22-25	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	137-149
11255228-3	2001	Analysis of mRNA from ROS 25/1, UMR 106 and ROS 17/2.8 cells revealed transcripts for both 11 beta-HSD type 1 (11 beta-HSD1) and type 2 (11 beta-HSD2) in all three cell lines.	ros	44-47	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	137-149
11255228-4	2001	However, enzyme activity studies showed only high affinity dehydrogenase activity (inactivation of corticosterone (B) to 11-dehydrocorticosterone (A)), characteristic of 11 beta-HSD2; conversion of B to A was higher in ROS 25/1&gt; UMR 106 cells&gt;ROS 17/2.8.	ros	219-222	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	170-182
11255228-4	2001	However, enzyme activity studies showed only high affinity dehydrogenase activity (inactivation of corticosterone (B) to 11-dehydrocorticosterone (A)), characteristic of 11 beta-HSD2; conversion of B to A was higher in ROS 25/1&gt; UMR 106 cells&gt;ROS 17/2.8.	ros	249-252	hydroxysteroid 11-beta dehydrogenase 2	Rattus norvegicus	170-182
28489580-3	2017	Here we demonstrate that autophagy induction by rapamycin suppressed the production of IL-1beta and IL-18 in lipopolysaccharide- and adenosine triphosphate-activated macrophages at the post-transcriptional level by eliminating mitochondrial ROS (mtROS) and pro-IL1beta in a p62/SQSTM1-dependent manner.	ros	241-244	interleukin 18	Homo sapiens	100-105
28635220-3	2017	Apoptosis and ROS expression in B-CPAP cells were detected by flow cytometry.	ros	14-17	centromere protein J	Homo sapiens	34-38
34255741-7	2021	Mechanistically, we demonstrate that loss of Angptl4 in hepatocytes promotes FA uptake which results in increased FA oxidation, ROS production, and AMPK activation.	ros	128-131	angiopoietin-like 4	Mus musculus	45-52
34169392-0	2021	ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells.	ros	58-61	glutathione peroxidase 4	Homo sapiens	23-27
28606256-3	2017	The affection of overexpression of SIRT1 on the oxLDL induced-inflammatory response and ROS generation had been detected in this study.	ros	88-91	sirtuin 1	Homo sapiens	35-40
11384866-2	2001	In ROS 17/2.8 cells, the estrogen-induced marker enzyme creatine kinase B (CKB) was stimulated by raloxifene, tamoxifen and tamoxifen methiodide to a specific activity equal to or greater than that induced by 10 nM E(2).	ros	3-6	creatine kinase B	Rattus norvegicus	56-73
11384866-2	2001	In ROS 17/2.8 cells, the estrogen-induced marker enzyme creatine kinase B (CKB) was stimulated by raloxifene, tamoxifen and tamoxifen methiodide to a specific activity equal to or greater than that induced by 10 nM E(2).	ros	3-6	creatine kinase B	Rattus norvegicus	75-78
10491222-0	1999	Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I.	ros	29-32	insulin-like growth factor 2	Rattus norvegicus	60-66
28588482-12	2017	Conclusions: FLL treatment may suppress oxidative stress response in OVX rats via regulating the Nox4/ROS/NF-kappaB signaling pathway.	ros	102-105	NADPH oxidase 4	Rattus norvegicus	97-101
10491222-4	1999	Strain-related increase in proliferation in ROS cells was accompanied by a 4-fold increase in levels of insulin-like growth factor-II (IGF-II) in conditioned medium.	ros	44-47	insulin-like growth factor 2	Rattus norvegicus	104-141
34169392-6	2021	From the perspective of ROS clearance, Vitamin E enhanced GPX4 function to consume L-glutathione and eliminated excess intracellular ROS.	ros	24-27	glutathione peroxidase 4	Homo sapiens	58-62
10329388-3	1999	This study has demonstrated specific PTH/PTHrP receptor expression from the U3 promoter in the osteoblastic osteosarcoma ROS 17/2.8 cell line, which expresses the endogenous PTH/PTHrP receptor, compared to rat 2 fibroblasts which do not express the endogenous PTH/PTHrP receptor gene.	ros	121-124	parathyroid hormone-like hormone	Rattus norvegicus	41-46
34169392-6	2021	From the perspective of ROS clearance, Vitamin E enhanced GPX4 function to consume L-glutathione and eliminated excess intracellular ROS.	ros	133-136	glutathione peroxidase 4	Homo sapiens	58-62
10329388-3	1999	This study has demonstrated specific PTH/PTHrP receptor expression from the U3 promoter in the osteoblastic osteosarcoma ROS 17/2.8 cell line, which expresses the endogenous PTH/PTHrP receptor, compared to rat 2 fibroblasts which do not express the endogenous PTH/PTHrP receptor gene.	ros	121-124	parathyroid hormone-like hormone	Rattus norvegicus	178-183
34133931-5	2021	ANAC089 truncated mutants exhibit higher NO and lower ROS and ABA endogenous levels, alongside an altered thiol and disulfide homeostasis.	ros	54-57	NAC domain containing protein 89	Arabidopsis thaliana	0-7
10329388-3	1999	This study has demonstrated specific PTH/PTHrP receptor expression from the U3 promoter in the osteoblastic osteosarcoma ROS 17/2.8 cell line, which expresses the endogenous PTH/PTHrP receptor, compared to rat 2 fibroblasts which do not express the endogenous PTH/PTHrP receptor gene.	ros	121-124	parathyroid hormone-like hormone	Rattus norvegicus	178-183
10329388-6	1999	These data suggest that cell-specific expression in ROS 17/2.8 involves cell-specific elements within the PTH/PTHrP receptor promoter.	ros	52-55	parathyroid hormone-like hormone	Rattus norvegicus	110-115
9754575-3	1998	We show that RAG-1-/-, TCRbeta-/- , and p56lck-/- mice lack thymocyte ROS formation with epithelial cells, macrophages, or dendritic cells.	ros	70-73	recombination activating 1	Mus musculus	13-18
9754575-4	1998	TNC formation was not affected by TCRbeta and p56lck gene mutations but partially decreased in RAG-1-/- mice, indicating that TNC are the earliest thymocyte-stromal cell complexes formed in development, whereas ROS only appear after thymocytes have rearranged and expressed a functional TCRbeta chain.	ros	211-214	tenascin C	Homo sapiens	0-3
9754575-6	1998	Surprisingly, CD4-/- mice, but not MHC class II-/- mice, had significantly reduced numbers of TNC and ROS, in particular, a severe defect in ROS formation with thymic dendritic cells.	ros	102-105	CD4 antigen	Mus musculus	14-17
9754575-6	1998	Surprisingly, CD4-/- mice, but not MHC class II-/- mice, had significantly reduced numbers of TNC and ROS, in particular, a severe defect in ROS formation with thymic dendritic cells.	ros	141-144	CD4 antigen	Mus musculus	14-17
28447802-5	2017	In vitro, the high antioxidant capacity of BCA was determined by the FRAP assay, ABTS + scavenging method, and an ROS assay.	ros	114-117	B cell linker	Mus musculus	43-46
34204801-10	2021	Elevated mOGT expression affected the mitochondrial transmembrane potential and increased intramitochondrial ROS generation.	ros	109-112	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	Mus musculus	9-13
28415797-6	2017	Rab7 GTPase siRNA knocking down in isolated bone marrow lal-/- MDSCs or HD1B cells not only reduced over-activation of mTOR and its downstream effector S6, but also decreased glucose consumption, decreased ROS over-production, and increased healthy mitochondria by membrane potential measurement.	ros	206-209	RAB7A, member RAS oncogene family	Homo sapiens	0-4
28411231-8	2017	In addition, ANG-(1-7) attenuated the ANG II-induced increase in mitochondrial ROS generation, an effect that was abolished by A779 or Sirt3 shRNA.	ros	79-82	angiogenin	Rattus norvegicus	13-16
28411231-8	2017	In addition, ANG-(1-7) attenuated the ANG II-induced increase in mitochondrial ROS generation, an effect that was abolished by A779 or Sirt3 shRNA.	ros	79-82	angiogenin	Rattus norvegicus	38-41
28411231-10	2017	In summary, the protective effects of ANG-(1-7) on ANG II-induced cardiac hypertrophy and increased mitochondrial ROS production are mediated by elevated SOD2 expression via stimulation of Sirt3-dependent deacetylation of FoxO3a in cardiomyocytes.	ros	114-117	angiogenin	Rattus norvegicus	38-41
28411231-11	2017	Thus, activation of the ANG-(1-7)/Sirt3 signaling pathway could be a novel therapeutic strategy in the management of cardiac hypertrophy and associated complications.NEW &amp; NOTEWORTHY Chronic subcutaneous ANG-(1-7) has no effect on ANG II-induced elevations in blood pressure but significantly attenuates ANG II-induced cardiac hypertrophy and fibrosis by a mitochondrial ROS-dependent mechanism.	ros	375-378	angiogenin	Rattus norvegicus	24-27
28411231-11	2017	Thus, activation of the ANG-(1-7)/Sirt3 signaling pathway could be a novel therapeutic strategy in the management of cardiac hypertrophy and associated complications.NEW &amp; NOTEWORTHY Chronic subcutaneous ANG-(1-7) has no effect on ANG II-induced elevations in blood pressure but significantly attenuates ANG II-induced cardiac hypertrophy and fibrosis by a mitochondrial ROS-dependent mechanism.	ros	375-378	angiogenin	Rattus norvegicus	208-211
9572838-3	1998	The data show that the PTH/PTHrP receptor is rapidly phosphorylated in ROS 17/2.8 cells with a maximum occurring at 20 min.	ros	71-74	parathyroid hormone-like hormone	Rattus norvegicus	27-32
9572838-4	1998	The phosphorylation was dose-dependent; it occurred with PTH concentrations that are known to downregulate the PTH/PTHrP receptor in ROS 17/2.8 cells.	ros	133-136	parathyroid hormone-like hormone	Rattus norvegicus	115-120
9572838-6	1998	PTH/PTHrP receptor phosphorylation in ROS 17/2.8, COS-7, and LLCPK-1 cells was also stimulated with forskolin and phorbol myristate acetate (PMA).	ros	38-41	parathyroid hormone-like hormone	Rattus norvegicus	4-9
9357854-0	1997	Differential induction of c-fos, c-jun, and apoptosis in lung epithelial cells exposed to ROS or RNS.	ros	90-93	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
34107901-13	2021	The knockout of adiponectin gene by siRNA increased ROS production, resulting in the activation of NLRP3 inflammasome and the phosphorylation of NF-kappaB in podocytes.	ros	52-55	adiponectin, C1Q and collagen domain containing	Mus musculus	16-27
34107901-13	2021	The knockout of adiponectin gene by siRNA increased ROS production, resulting in the activation of NLRP3 inflammasome and the phosphorylation of NF-kappaB in podocytes.	ros	52-55	NLR family, pyrin domain containing 3	Mus musculus	99-104
34107901-15	2021	CONCLUSIONS: Our study showed that adiponectin ameliorated PA-induced podocyte injury in vitro and HFD-induced injury in vivo via inhibiting the ROS/NF-kappaB/NLRP3 pathway.	ros	145-148	adiponectin, C1Q and collagen domain containing	Mus musculus	35-46
9175844-1	1997	This study was designed to characterize the effect of Cd2+ on Ca2+ metabolism in ROS 17/2.8 cells.	ros	81-84	Cd2 molecule	Rattus norvegicus	54-57
34199427-9	2021	Cellular assays showed that DOPAC reduced cytotoxicity and ROS production induced by alpha-synuclein aggregates.	ros	59-62	synuclein alpha	Homo sapiens	85-100
8980892-0	1996	Osteogenic action of parathyroid hormone-related peptide (1-141) in rat ROS cells.	ros	72-75	parathyroid hormone-like hormone	Rattus norvegicus	21-56
8980892-2	1996	Using the PTHrP-overexpressing ROS cells (ROS/PLP/6), we analyzed in vitro cell characterization and in vivo osteogenic properties.	ros	31-34	parathyroid hormone-like hormone	Rattus norvegicus	10-15
8980892-2	1996	Using the PTHrP-overexpressing ROS cells (ROS/PLP/6), we analyzed in vitro cell characterization and in vivo osteogenic properties.	ros	42-45	parathyroid hormone-like hormone	Rattus norvegicus	10-15
8980892-8	1996	Our study provides clear evidence that the in vivo osteogenic function in ROS cells is potentiated by PTHrP, through an autocrine/paracrine mode of action.	ros	74-77	parathyroid hormone-like hormone	Rattus norvegicus	102-107
8641188-3	1996	Hep G2 growth medium was found to contain relatively large amounts of immunoreactive PTHrP (30 vs. 1-2 pM in medium not exposed to cells), and the PTHrP in growth medium (conditioned medium) was shown to contain N-terminal PTHrP biological activity, as assessed by the ability of the medium to stimulate cAMP production in rat osteosarcoma cells (ROS 17/2.8).	ros	347-350	parathyroid hormone-like hormone	Rattus norvegicus	147-152
8641188-3	1996	Hep G2 growth medium was found to contain relatively large amounts of immunoreactive PTHrP (30 vs. 1-2 pM in medium not exposed to cells), and the PTHrP in growth medium (conditioned medium) was shown to contain N-terminal PTHrP biological activity, as assessed by the ability of the medium to stimulate cAMP production in rat osteosarcoma cells (ROS 17/2.8).	ros	347-350	parathyroid hormone-like hormone	Rattus norvegicus	147-152
8799846-12	1996	In ROS 17/2.8 and UMR-106 cells, in contrast, proliferation was inhibited by anti-tenascin.	ros	3-6	tenascin C	Rattus norvegicus	82-90
8664302-2	1996	We have previously shown that in the ROS 17/2.8 rat osteosarcoma cell line, which continuously expresses the osteocalcin gene, key regulatory elements reside in two DNase I hypersensitive sites that are fucntionally correlated with transcriptional activity.	ros	37-40	deoxyribonuclease 1	Rattus norvegicus	165-172
7479833-8	1995	Our results confirm that NMP-1/YY1 is a ubiquitous protein that is present in both human cells and in rat osteosarcoma ROS 17/2.8 cells.	ros	119-122	YY1 transcription factor	Rattus norvegicus	25-30
8592514-7	1995	Both distal and proximal GREs specifically bound glucocorticoid receptor present in ROS 17/2.8 nuclear extracts as shown by competition with wild type and mutated oligonucleotides and antibody inhibition of binding.	ros	84-87	nuclear receptor subfamily 3, group C, member 1	Rattus norvegicus	49-72
7540349-9	1995	Furthermore, constitutive-type NOS (c-NOS) and inducible-type NOS (i-NOS) mRNA expression was detected in ROS 17/2.8 cells after reverse transcription and polymerase chain reaction amplification.	ros	106-109	nitric oxide synthase 3	Rattus norvegicus	13-34
7540349-9	1995	Furthermore, constitutive-type NOS (c-NOS) and inducible-type NOS (i-NOS) mRNA expression was detected in ROS 17/2.8 cells after reverse transcription and polymerase chain reaction amplification.	ros	106-109	nitric oxide synthase 3	Rattus norvegicus	36-41
8300629-8	1994	Gel retardation assays with ROS 17/2.8 nuclear extracts suggest that the VDR binds to the mouse osteopontin VDRE predominantly as a heterodimer with retinoid X receptor(s) (RXR(s)).	ros	28-31	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	73-76
8294491-3	1994	When the rat osteoblastic cell line, ROS 17/2.8, is induced to differentiate with 1,25-dihydroxyvitamin D3, expression of creatine kinase-b (ck-b), a pivotal enzyme in energy metabolism, is enhanced.	ros	37-40	creatine kinase B	Rattus norvegicus	122-139
8294491-3	1994	When the rat osteoblastic cell line, ROS 17/2.8, is induced to differentiate with 1,25-dihydroxyvitamin D3, expression of creatine kinase-b (ck-b), a pivotal enzyme in energy metabolism, is enhanced.	ros	37-40	creatine kinase B	Rattus norvegicus	141-145
8294491-6	1994	In addition, the contribution of posttranscriptional regulatory mechanisms is suggested by (1) the increase in ck-b mRNA abundance exceeds that of transcription rate, indicating an increase in message stability, (2) the increase in ck-b mRNA precedes and exceeds that of protein activity, indicating translational modulation, and (3) RNA mobility-shift assays indicate that a cytosolic factor in ROS 17/2.8 cells interacts specifically with the highly conserved 3"-untranslated region of the ck-b mRNA.	ros	396-399	creatine kinase B	Rattus norvegicus	111-115
8294491-6	1994	In addition, the contribution of posttranscriptional regulatory mechanisms is suggested by (1) the increase in ck-b mRNA abundance exceeds that of transcription rate, indicating an increase in message stability, (2) the increase in ck-b mRNA precedes and exceeds that of protein activity, indicating translational modulation, and (3) RNA mobility-shift assays indicate that a cytosolic factor in ROS 17/2.8 cells interacts specifically with the highly conserved 3"-untranslated region of the ck-b mRNA.	ros	396-399	creatine kinase B	Rattus norvegicus	232-236
8294491-6	1994	In addition, the contribution of posttranscriptional regulatory mechanisms is suggested by (1) the increase in ck-b mRNA abundance exceeds that of transcription rate, indicating an increase in message stability, (2) the increase in ck-b mRNA precedes and exceeds that of protein activity, indicating translational modulation, and (3) RNA mobility-shift assays indicate that a cytosolic factor in ROS 17/2.8 cells interacts specifically with the highly conserved 3"-untranslated region of the ck-b mRNA.	ros	396-399	creatine kinase B	Rattus norvegicus	232-236
8275958-1	1994	To study mechanisms controlling the expression of PTH/PTH-related peptide (PTHrP) receptors in ROS 17/2.8 and OK cells, we investigated the regulation of PTH/PTHrP receptor availability and receptor mRNA levels by glucocorticoids and PTH.	ros	95-98	parathyroid hormone-like hormone	Rattus norvegicus	75-80
8466503-2	1993	The rat clonal strain of the osteoblast-like cell, ROS 17/2.8-5, can express low levels of PTHrP in the cytoplasm; however, the autocrine function of PTHrP in ROS cells has not yet been clarified.	ros	51-54	parathyroid hormone-like hormone	Rattus norvegicus	91-96
8466503-2	1993	The rat clonal strain of the osteoblast-like cell, ROS 17/2.8-5, can express low levels of PTHrP in the cytoplasm; however, the autocrine function of PTHrP in ROS cells has not yet been clarified.	ros	51-54	parathyroid hormone-like hormone	Rattus norvegicus	150-155
8466503-2	1993	The rat clonal strain of the osteoblast-like cell, ROS 17/2.8-5, can express low levels of PTHrP in the cytoplasm; however, the autocrine function of PTHrP in ROS cells has not yet been clarified.	ros	159-162	parathyroid hormone-like hormone	Rattus norvegicus	150-155
8466503-8	1993	These PTHrP-overexpressing ROS cells provide a model in vitro system to clarify the mechanism by which PTHrP acts in an autocrine/paracrine fashion.	ros	27-30	parathyroid hormone-like hormone	Rattus norvegicus	6-11
8466503-8	1993	These PTHrP-overexpressing ROS cells provide a model in vitro system to clarify the mechanism by which PTHrP acts in an autocrine/paracrine fashion.	ros	27-30	parathyroid hormone-like hormone	Rattus norvegicus	103-108
1312452-2	1992	Activation of PKC by incubation for 4 h with the phorbol ester phorbol 12-myristate 13-acetate (PMA) resulted in a comparable dose-dependent decrease in 1,25-dihydroxyvitamin D3 binding in the osteoblast-like cell lines UMR 106 and ROS 17/2.8, with a maximum inhibition at 100 nM and an IC50 at 5 nM PMA.	ros	232-235	protein kinase C, gamma	Rattus norvegicus	14-17
1312452-11	1992	The present study demonstrates that PKC is involved in the regulation of VDR in UMR 106 and ROS 17/2.8 and that PKC interacts with cAMP in the regulation of VDR.	ros	92-95	protein kinase C, gamma	Rattus norvegicus	36-39
1313566-2	1992	Using expression cloning, we have isolated a cDNA clone encoding rat bone PTH/PTHrP receptor from rat osteosarcoma (ROS 17/2.8) cells.	ros	116-119	parathyroid hormone-like hormone	Rattus norvegicus	78-83
1786699-5	1991	TGF alpha potentiated the effects of either bPTH-(1-34) or hPTHrP-(1-34) on the stimulation of adenylate cyclase in osteoblast-like ROS 17/2.8 cells.	ros	132-135	transforming growth factor alpha	Rattus norvegicus	0-9
1658637-7	1991	Significant phosphorylation of transfected full-length hVDR was observed in ROS 17/2.8 cells, and it was less dependent on the presence of 1,25-dihydroxyvitamin D3 than that of the endogenous rat receptor.	ros	76-79	vitamin D receptor	Homo sapiens	55-59
1999144-7	1991	In addition, covalent cross-linking of intact NRK 49F and ROS 17/2.8 cells with either [125I]TGF-beta or 125I-[Tyr40] PTHrp-(1-40) revealed the presence of several distinct affinity-labeled receptor species for TGF-beta in both cell types and the 80K PTH/PTHrp receptors in ROS 17/2.8 cells.	ros	58-61	parathyroid hormone-like hormone	Rattus norvegicus	118-123
1840380-6	1991	M-ROS were enriched in CD4-CD8- thymocytes and had a reduced content of thymocytes expressing high TcR-CD3 levels; they nevertheless contained some mature thymocytes, but only of the CD4+CD8-CD3++ category.	ros	2-5	CD4 antigen	Mus musculus	23-26
1840380-9	1991	The CD4+CD8+CD3++ subpopulation, believed to be a developmental intermediate between cortical thymocytes and mature T cells, was present in both ROS populations.	ros	145-148	CD4 antigen	Mus musculus	4-7
2173777-3	1990	The gag-free ros protein was expressed from one of the mutant retroviruses at a level 10 to 50% of that of the wild-type UR2.	ros	13-16	uncharacterized LOC107052719	Gallus gallus	4-7
2173777-5	1990	The specific tyrosine protein kinase activity of gag-free ros protein is about 10- to 20-fold reduced as judged by in vitro autophosphorylation.	ros	15-18	uncharacterized LOC107052719	Gallus gallus	49-52
2173777-6	1990	The gag-free ros protein is still capable of associating with membrane fractions including the plasma membrane, indicating that sequences essential for recognition and binding membranes must be located within ros.	ros	13-16	uncharacterized LOC107052719	Gallus gallus	4-7
2173777-6	1990	The gag-free ros protein is still capable of associating with membrane fractions including the plasma membrane, indicating that sequences essential for recognition and binding membranes must be located within ros.	ros	209-212	uncharacterized LOC107052719	Gallus gallus	4-7
2173777-8	1990	The variants were found to have regained the gag sequence fused to the 5" end of the ros, apparently via recombination with the helper virus or through intramolecular recombination between ros and upstream gag sequences in the same virus construct.	ros	85-88	uncharacterized LOC107052719	Gallus gallus	45-48
2173777-8	1990	The variants were found to have regained the gag sequence fused to the 5" end of the ros, apparently via recombination with the helper virus or through intramolecular recombination between ros and upstream gag sequences in the same virus construct.	ros	85-88	uncharacterized LOC107052719	Gallus gallus	206-209
2173777-8	1990	The variants were found to have regained the gag sequence fused to the 5" end of the ros, apparently via recombination with the helper virus or through intramolecular recombination between ros and upstream gag sequences in the same virus construct.	ros	189-192	uncharacterized LOC107052719	Gallus gallus	45-48
2173777-9	1990	All three variants analyzed code for gag-ros fusion protein larger than 68 kDa.	ros	41-44	uncharacterized LOC107052719	Gallus gallus	37-40
2173777-10	1990	The gag-ros recombination junction of one of the transforming variants was sequenced and found to consist of a p19-p10-p27-ros fusion sequence.	ros	8-11	uncharacterized LOC107052719	Gallus gallus	4-7
2173777-10	1990	The gag-ros recombination junction of one of the transforming variants was sequenced and found to consist of a p19-p10-p27-ros fusion sequence.	ros	123-126	uncharacterized LOC107052719	Gallus gallus	4-7
2173777-11	1990	We conclude that the gag sequence is essential for the transforming activity of P68gag-ros but is not important for its membrane association.	ros	87-90	uncharacterized LOC107052719	Gallus gallus	21-24
2188977-2	1990	At 37 degrees C, degradation of insulin receptors photoaffinity labeled on the cell surface (440 kDa) was most rapid for the hybrid hIR.ros (t1/2 1.0 +/- 0.1 h), intermediate for the wild-type hIR (t1/2 2.7 +/- 0.5 h), and slowest for the endogenous CHO insulin receptors (t1/2 3.7 +/- 0.7 h).	ros	136-139	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	132-135
2188977-2	1990	At 37 degrees C, degradation of insulin receptors photoaffinity labeled on the cell surface (440 kDa) was most rapid for the hybrid hIR.ros (t1/2 1.0 +/- 0.1 h), intermediate for the wild-type hIR (t1/2 2.7 +/- 0.5 h), and slowest for the endogenous CHO insulin receptors (t1/2 3.7 +/- 0.7 h).	ros	136-139	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	193-196
2188977-3	1990	Initial intracellular accumulation of the hIR.ros hybrid was also most rapid, reaching maximal amounts in 20 min following which the receptors disappeared rapidly from the intracellular compartment.	ros	46-49	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	42-45
2188977-5	1990	Chloroquine, a lysosomotropic agent, inhibited degradation of both the wild-type hIR and the chimeric hIR.ros and increased their intracellular accumulation.	ros	106-109	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	81-84
28469960-3	2017	In cell models, p62/SQSTM1 levels affected the Nrf2-Keap1 pathway, ROS levels, GSH/GSSG ratios and cell growth, especially under irradiation rather than under CDDP exposure, which was toxic despite p62/SQSTM1 status.	ros	67-70	sequestosome 1	Homo sapiens	16-19
28469960-3	2017	In cell models, p62/SQSTM1 levels affected the Nrf2-Keap1 pathway, ROS levels, GSH/GSSG ratios and cell growth, especially under irradiation rather than under CDDP exposure, which was toxic despite p62/SQSTM1 status.	ros	67-70	sequestosome 1	Homo sapiens	20-26
28361889-8	2017	SUV39H augments intracellular ROS levels in a SIRT1-dependent manner.	ros	30-33	sirtuin 1	Homo sapiens	46-51
28137584-9	2017	ROS scavenge agent N-acetyl-l-cysteine (NAC) completely reversed the effects of niclosamide in increasing cellular ROS, inhibiting proliferation and inducing apoptosis, suggesting that oxidative stress induction is the mechanism of action of niclosamide in cervical cancer cells.	ros	0-3	X-linked Kx blood group	Homo sapiens	40-43
28137584-9	2017	ROS scavenge agent N-acetyl-l-cysteine (NAC) completely reversed the effects of niclosamide in increasing cellular ROS, inhibiting proliferation and inducing apoptosis, suggesting that oxidative stress induction is the mechanism of action of niclosamide in cervical cancer cells.	ros	115-118	X-linked Kx blood group	Homo sapiens	40-43
28094181-5	2017	We have observed that FCP1 as well as FCP2 clearly induced oxidative DNA lesions in cancer cells and increased the level of cellular ROS.	ros	133-136	FCP1	Homo sapiens	22-26
28099881-0	2017	Mesencephalic astrocyte-derived neurotrophic factor alleviated 6-OHDA-induced cell damage via ROS-AMPK/mTOR mediated autophagic inhibition.	ros	94-97	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	98-102
28069524-6	2017	Our data showed that ER stress induced by ATG14 was due to the lipophagy-mediated FFA accumulation, which resulted in ROS-dependent mitochondrial stress leading to apoptosis.	ros	118-121	autophagy related 14	Homo sapiens	42-47
28104397-9	2017	Furthermore, PINK1 overexpression stabilized electron transport chain (ETC) activity, increased ATP production, mPTP opening and mitochondrial membrane potential (MMP), inhibited ROS-generating mitochondria, implying PINK1 alleviates H/R induced mitochondrial dysfunction in cardiomyocytes.	ros	179-182	PTEN induced kinase 1	Rattus norvegicus	13-18
28230797-0	2017	ZYZ-772 Prevents Cardiomyocyte Injury by Suppressing Nox4-Derived ROS Production and Apoptosis.	ros	66-69	NADPH oxidase 4	Rattus norvegicus	53-57
28196147-0	2017	Correction: Inhibition of p38 MAPK Signaling Augments Skin Tumorigenesis via NOX2 Driven ROS Generation.	ros	89-92	cytochrome b-245 beta chain	Homo sapiens	77-81
2188977-5	1990	Chloroquine, a lysosomotropic agent, inhibited degradation of both the wild-type hIR and the chimeric hIR.ros and increased their intracellular accumulation.	ros	106-109	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	102-105
2188977-6	1990	However, the chloroquine effect was much more marked for the hIR.ros receptors whose intracellular accumulation was increased by greater than 300% (in comparison with approximately 60% increase for the wild-type hIR), demonstrating marked intracellular degradation of the hybrid hIR.ros at chloroquine-sensitive sites.	ros	65-68	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	61-64
2188977-6	1990	However, the chloroquine effect was much more marked for the hIR.ros receptors whose intracellular accumulation was increased by greater than 300% (in comparison with approximately 60% increase for the wild-type hIR), demonstrating marked intracellular degradation of the hybrid hIR.ros at chloroquine-sensitive sites.	ros	65-68	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	212-215
2188977-6	1990	However, the chloroquine effect was much more marked for the hIR.ros receptors whose intracellular accumulation was increased by greater than 300% (in comparison with approximately 60% increase for the wild-type hIR), demonstrating marked intracellular degradation of the hybrid hIR.ros at chloroquine-sensitive sites.	ros	65-68	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	212-215
2188977-7	1990	Insulin-induced down-regulation of the cell surface hIR.ros (52% loss in 3 h) was also more marked than the wild-type hIR (approximately 30% loss in 3 h).	ros	56-59	potassium inwardly rectifying channel subfamily J member 4	Homo sapiens	52-55
34078931-6	2021	As the results, we found that treatment with recombinant human His6-GABARAP protein promoted cell proliferation, inhibited apoptosis, and reduced ROS generation by increasing autophagic activity, particularly when co-cultured with IL-1beta.	ros	146-149	GABA type A receptor-associated protein	Homo sapiens	68-75
33774201-3	2021	AlP/CPT-NPs were prepared using photosensitizer Al(III) phthalocyanine chloride disulfonic acid (AlP) and ROS-activatable camptothecin prodrug (CPT-PD).	ros	106-109	ATHS	Homo sapiens	0-3
27872198-4	2017	Malondialdehyde concentration increased, whereas the ROS-detoxifying enzyme Mn2+ superoxide dismutase (MnSOD) and aconitase lost activity.	ros	53-56	superoxide dismutase 2	Rattus norvegicus	76-101
27872198-4	2017	Malondialdehyde concentration increased, whereas the ROS-detoxifying enzyme Mn2+ superoxide dismutase (MnSOD) and aconitase lost activity.	ros	53-56	superoxide dismutase 2	Rattus norvegicus	103-108
34078931-6	2021	As the results, we found that treatment with recombinant human His6-GABARAP protein promoted cell proliferation, inhibited apoptosis, and reduced ROS generation by increasing autophagic activity, particularly when co-cultured with IL-1beta.	ros	146-149	interleukin 1 alpha	Homo sapiens	231-239
33816292-0	2021	Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K-AKT Pathway and Activating the AMPK-ROS Pathway.	ros	150-153	ATP citrate lyase	Homo sapiens	10-14
28143493-4	2017	METHODS: To clarify these conflicting findings, we examined the ability of CCL2 to alter naive and tumor entrained neutrophil production of ROS, release of granzyme-B, and killing of tumor cells in multiple mouse models of breast cancer.	ros	140-143	chemokine (C-C motif) ligand 2	Mus musculus	75-79
33816292-15	2021	Knockdown of ACLY alleviated cisplatin resistance, and works synergistically with cisplatin treatment to induce apoptosis in A2780/CDDP cells by inhibiting the PI3K-AKT pathway and activating AMPK-ROS pathway.	ros	197-200	ATP citrate lyase	Homo sapiens	13-17
34821332-5	2021	In a cell assay, this nanoplatform could function as an antagonist of GPX4 and agonist of SOD-1, resulting in intracellular ROS and H2O2 accumulation.	ros	124-127	glutathione peroxidase 4	Homo sapiens	70-74
33816292-18	2021	Conclusions: Knockdown of ACLY attenuated cisplatin resistance by inhibiting the PI3K-AKT pathway and activating the AMPK-ROS pathway.	ros	122-125	ATP citrate lyase	Homo sapiens	26-30
28143512-4	2017	RESULTS: Progranulin treatment increased iNOS expression, NO synthesis and ROS generation, and elevated protein expressions of CHOP, GRP78 and the phosphorylation of PERK, and caused a significant increase in Atg7 and LC3-II protein expression and a decreased p62 expression, and decreased insulin-stimulated tyrosine phosphorylation of IRS-1 and glucose uptake, demonstrating that progranulin activated oxidative stress and ER stress, elevated autophagy and induced insulin insensitivity in adipocytes and adipose tissue of mice.	ros	75-78	granulin	Mus musculus	9-20
28139737-4	2017	The enhanced cisplatin cytotoxicity in histone H4 knockdown cells was associated with proteasomal degradation of RIP1, accumulation of cellular ROS and degradation of IAPs (cIAP1 and XIAP).	ros	144-147	H4 clustered histone 9	Homo sapiens	39-49
28011270-11	2017	In conclusion, our study indicates that H2S downregulates Ang II-induced atrial Kv1.5 expression by attenuating Nox4-related ROS-triggered P-Smad2/3 and P-ERK 1/2 activation during AF.	ros	125-128	NADPH oxidase 4	Rattus norvegicus	112-116
34318699-7	2021	And ER stress-mediated apoptosis caused by ROS accumulation depended on the inactivation of Wnt/beta-catenin pathway.	ros	43-46	catenin beta 1	Homo sapiens	96-108
28017719-4	2017	Moreover, blocking miR-217 expression antagonized HG-induced cell injury by attenuating the adverse role of HG on cell viability and inhibiting ROS levels and cell apoptosis.	ros	144-147	microRNA 217	Homo sapiens	19-26
28067240-5	2017	Co-culture with CD8+ T cells upregulates NCC in mouse DCT cells via ROS-induced activation of Src kinase, up-regulation of the K+ channel Kir4.1, and stimulation of the Cl- channel ClC-K.	ros	68-71	CD8a molecule	Homo sapiens	16-19
33233421-11	2020	Further, OLE significantly diminished the presence of oxidative system parameters, while upregulated the ROS disruptor, Sestrin-3.	ros	105-108	sestrin 3	Mus musculus	120-129
34318699-9	2021	In short, ROS-mediated ER stress was involved in alpha-mangostin triggered apoptosis, which might depended on Wnt/beta-catenin signaling inactivation.	ros	10-13	catenin beta 1	Homo sapiens	114-126
29237157-11	2017	In addition, we found that hypoxia increased ROS production and that ROS inhibitors (NAC) blocked GLI1-dependent EMT process and invasion under hypoxic conditions.	ros	69-72	GLI family zinc finger 1	Homo sapiens	98-102
35346830-9	2022	This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers.	ros	62-65	glutathione peroxidase 4	Homo sapiens	79-83
29237157-15	2017	CONCLUSION: Our findings indicate that hypoxia triggers ROS-mediated GLI1-dependent EMT progress and invasion of HCC cells through induction of NOX4 expression.	ros	56-59	GLI family zinc finger 1	Homo sapiens	69-73
35346830-9	2022	This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers.	ros	62-65	interleukin 1 alpha	Homo sapiens	156-164
35446108-8	2022	Cells that were treated with ROS scavengers, N-acetyl-L-cysteine or MitoQ, significantly reduced the amount of ROS and Tau dimerization, indicating the involvement of oxidative stress in Tau aggregation.	ros	29-32	microtubule associated protein tau	Homo sapiens	119-122
35446108-8	2022	Cells that were treated with ROS scavengers, N-acetyl-L-cysteine or MitoQ, significantly reduced the amount of ROS and Tau dimerization, indicating the involvement of oxidative stress in Tau aggregation.	ros	29-32	microtubule associated protein tau	Homo sapiens	187-190
27372348-5	2017	WA prevents p53 alterations and inactivates overexpressed MDM2 through ARF and ROS production.	ros	79-82	MDM2 proto-oncogene	Homo sapiens	58-62
35446108-8	2022	Cells that were treated with ROS scavengers, N-acetyl-L-cysteine or MitoQ, significantly reduced the amount of ROS and Tau dimerization, indicating the involvement of oxidative stress in Tau aggregation.	ros	111-114	microtubule associated protein tau	Homo sapiens	187-190
35288287-15	2022	Moreover, it attenuated oxidative stress in vivo as it significantly increased the survival rate of ROS stressed C. elegans worms, decreased intracellular ROS, decreased the juglone-induced HSP16 expression and enhanced the nuclear localization of DAF16 in a dose-dependent manner.	ros	100-103	Fork-head domain-containing protein;Forkhead box protein O	Caenorhabditis elegans	248-253
28751937-11	2017	Suppression of ROS generation using NAC or apocynin or by silencing gp91phox and p47phox all demonstrated that decreasing the level of ROS inhibited the LPS-induced inflammatory response.	ros	15-18	NLR family, pyrin domain containing 1A	Mus musculus	36-39
28751937-11	2017	Suppression of ROS generation using NAC or apocynin or by silencing gp91phox and p47phox all demonstrated that decreasing the level of ROS inhibited the LPS-induced inflammatory response.	ros	135-138	NLR family, pyrin domain containing 1A	Mus musculus	36-39
28751937-12	2017	Collectively, these results confirmed that myricitrin exhibited anti-inflammatory activity by blocking the activation of JAKs and the downstream transcription factor STAT1, which may result from the downregulation of NOX2-dependent ROS production mediated by myricitrin.	ros	232-235	signal transducer and activator of transcription 1	Mus musculus	166-171
35395625-6	2022	Elevated NOX4 expression in Piezo1-deficient MuSCs increases ROS levels and DNA damage, causing P53-dependent cellular senescence and cell death.	ros	61-64	piezo-type mechanosensitive ion channel component 1	Mus musculus	28-34
35395625-6	2022	Elevated NOX4 expression in Piezo1-deficient MuSCs increases ROS levels and DNA damage, causing P53-dependent cellular senescence and cell death.	ros	61-64	transformation related protein 53, pseudogene	Mus musculus	96-99
29081885-7	2017	These data were associated with the modification effects on expression levels of genes involved in de novo fat synthesis (SREBP-1c, ACC), triacylglycerol catabolism (PPARalpha, CPT1A, and ACOX1), inflammation (NF-kappaB, IL-6, TNF-alpha, and MCP-1), and oxidative stress (ROS, MDA, GSH, and SOD).	ros	272-275	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	188-193
35504134-8	2022	The reduced ROS production and dsDNA release may be responsible for attenuated AIM2 activation by NAG-1/GDF15 upon fatty acid overload.	ros	12-15	growth differentiation factor 15	Mus musculus	98-103
27773793-6	2016	On contrary, N-Acety-l-Cysteine (NAC) decreased Hcy-evoked ROS production and significantly ameliorated DNA damage and improved cell survival.	ros	59-62	X-linked Kx blood group	Homo sapiens	13-31
27773793-6	2016	On contrary, N-Acety-l-Cysteine (NAC) decreased Hcy-evoked ROS production and significantly ameliorated DNA damage and improved cell survival.	ros	59-62	X-linked Kx blood group	Homo sapiens	33-36
35504134-8	2022	The reduced ROS production and dsDNA release may be responsible for attenuated AIM2 activation by NAG-1/GDF15 upon fatty acid overload.	ros	12-15	growth differentiation factor 15	Mus musculus	104-109
35616702-0	2022	Correction to: Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway.	ros	136-139	matrix metallopeptidase 7	Homo sapiens	15-41
35575090-6	2022	Using ATPIF1 gain- and loss-of-function cell models, we demonstrated that stalled electron flow due to impaired ATP synthase activity triggered mitochondrial ROS generation, which stabilized HIF1alpha, leading to transcriptional activation of glycolysis.	ros	158-161	ATPase inhibitory factor 1	Mus musculus	6-12
27816841-5	2016	In this process, ROS dominates the antioxidants factors such as GPx, GS, GSH, MT-III, Catalase, SOD, BDNF, and CERB, and finally leads to cognitive dysfunction.	ros	17-20	brain derived neurotrophic factor	Homo sapiens	101-105
27876813-3	2016	Our results showed that treatment of human bronchial epithelial (BEAS-2B) cells with arsenic induces ROS through p47phox, one of the NOX subunits that is the key source of arsenic-induced ROS.	ros	101-104	neutrophil cytosolic factor 1	Homo sapiens	113-120
27876813-3	2016	Our results showed that treatment of human bronchial epithelial (BEAS-2B) cells with arsenic induces ROS through p47phox, one of the NOX subunits that is the key source of arsenic-induced ROS.	ros	188-191	neutrophil cytosolic factor 1	Homo sapiens	113-120
35575090-6	2022	Using ATPIF1 gain- and loss-of-function cell models, we demonstrated that stalled electron flow due to impaired ATP synthase activity triggered mitochondrial ROS generation, which stabilized HIF1alpha, leading to transcriptional activation of glycolysis.	ros	158-161	hypoxia inducible factor 1, alpha subunit	Mus musculus	191-200
27561486-4	2016	The results indicated that pretreatment of PC12 cells with CPA-1 and CPB-2 significantly increased cell survival, Ca(2+) overload and ROS generation.	ros	134-137	carboxypeptidase A1	Rattus norvegicus	59-64
35615575-5	2022	FFA triggers a large amount of ROS (generated from NOX4 and damaged mitochondria), promoting the ZNF24 expression and suppressing ZN24 sumoylation, both of which enhance the PD-L1 transcription and expression.	ros	31-34	zinc finger protein 24	Homo sapiens	97-102
27806094-9	2016	Moreover, measurement of intracellular [Ca2+] and ROS following VEGFR2 inhibition and EGF treatment proved that VEGFR2 is not implicated in EGF-induced Ca2+ release whereas it boosts EGF-induced ROS production.	ros	195-198	kinase insert domain receptor	Homo sapiens	112-118
35615575-5	2022	FFA triggers a large amount of ROS (generated from NOX4 and damaged mitochondria), promoting the ZNF24 expression and suppressing ZN24 sumoylation, both of which enhance the PD-L1 transcription and expression.	ros	31-34	CD274 molecule	Homo sapiens	174-179
35631624-7	2022	A significant increase in caspase 3 and ROS/RNS level but a decrease in total ATP were observed in USC treated with ddC, TFV, RAL, and RTNN.	ros	40-43	FAM20C golgi associated secretory pathway kinase	Homo sapiens	44-47
26895796-4	2016	ROS can inhibit SIRT-1 activity by initiating oxidative modifications on its cysteine residues, and suppression of SIRT-1 enhances the NF-kappaB signaling resulting in inflammatory responses.	ros	0-3	sirtuin 1	Homo sapiens	16-22
35513484-7	2022	Present data showed that co-activation of CB1 and CB2 exerted cytotoxic effects on MDA-MB-231 cells by increasing apoptotic cell death through suppression of the NF-kappaB signaling pathway in an ROS-independent mechanism.	ros	196-199	cannabinoid receptor 2	Homo sapiens	50-53
27756472-0	2016	beta-Hydroxybutyrate induces bovine hepatocyte apoptosis via an ROS-p38 signaling pathway.	ros	64-67	mitogen-activated protein kinase 14	Bos taurus	68-71
27756472-9	2016	These results indicate that BHB induces bovine hepatocyte apoptosis through the ROS-p38-p53/Nrf2 signaling pathway.	ros	80-83	mitogen-activated protein kinase 14	Bos taurus	84-87
27655686-8	2016	We further showed that ROS-mediated cell death was the key mechanism by which PEITC induced cytotoxicity, since such cell death could be prevented by addition of antioxidant NAC.	ros	23-26	NLR family, pyrin domain containing 1A	Mus musculus	174-177
35503215-0	2022	Inhibition of miR-182-5p attenuates ROS and protects against myocardial ischemia-reperfusion injury by targeting STK17A.	ros	36-39	microRNA 182	Rattus norvegicus	14-21
35503215-12	2022	Inhibition of miR-182-5p significantly reduced the infarct size and decreased the serum CK-MB level of I/R rats, and significantly reduced the ROS level but increased the level of MnSOD and catalase.	ros	143-146	microRNA 182	Rattus norvegicus	14-21
35503215-14	2022	Furthermore, our results suggested that miR-182-5p targeted STK17A, and TK17A knockdown significantly increased the apoptotic rate and ROS level.	ros	135-138	microRNA 182	Rattus norvegicus	40-47
27475664-5	2016	AOPPs stimulation induced ROS generation and NF-kappa B p65 phosphorylation, which could be inhibited by soluble receptor for advanced glycan end products (sRAGE), NADPH oxidase inhibitor (apocynin), ROS scavenger (N-acetyl-cysteine, NAC).	ros	26-29	X-linked Kx blood group	Homo sapiens	234-237
35503215-15	2022	The inhibitory effect of miR-182-5p inhibitors on apoptotic rate, ROS, MnSOD, and catalase levels were abrogated by siSTK17A.	ros	66-69	microRNA 182	Rattus norvegicus	25-32
35503215-16	2022	These results indicate that miR-182-5p regulates the apoptosis and ROS and protects against myocardial I/R injury by targeting STK17A.	ros	67-70	microRNA 182	Rattus norvegicus	28-35
35087226-3	2022	Unlike apoptotic cell death, activation of p53 alone is not sufficient to induce ferroptosis directly; instead, through its metabolic targets, p53 is able to modulate the ferroptosis response in the presence of ferroptosis inducers such as GPX4 inhibitors or high levels of ROS.	ros	274-277	glutathione peroxidase 4	Homo sapiens	240-244
27368536-12	2016	Our results showed that the apoptotic genes AIF, CYC and caspase 3 might play crucial roles in hepatopancreas, however, the production of ROS in hemocytes might be important in shrimp defense against WSSV infection.	ros	138-141	apoptosis inducing factor mitochondria associated 1	Homo sapiens	44-47
35472707-5	2022	Here, we show that metabolic stress induces beta cell HIF-2alpha which stimulates anti-oxidant gene expression (e.g. Sod2 and Cat) and protects against mitochondrial ROS and subsequent mitochondrial damage.	ros	166-169	endothelial PAS domain protein 1	Mus musculus	54-64
26854822-0	2016	Metabolic characterization of imatinib-resistant BCR-ABL T315I chronic myeloid leukemia cells indicates down-regulation of glycolytic pathway and low ROS production.	ros	150-153	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	49-56
35472707-6	2022	Knockdown of HIF-2alpha in Min6 cells exaggerated chronic high glucose-induced mitochondrial damage and beta cell dysfunction by increasing mitochondrial ROS levels.	ros	154-157	endothelial PAS domain protein 1	Mus musculus	13-23
27264783-5	2016	Furthermore, by using pharmacological inhibitors, scavengers and molecular approaches, we identified that enhanced ROS generation via NOX2 and mitochondria, reduced Grx1/2 expression and GSH level associated with NFkappaB S-glutathionylation in PMNs from CML patients.	ros	115-118	cytochrome b-245 beta chain	Homo sapiens	134-138
35472707-7	2022	Moreover, inducible beta cell HIF-2alpha KO mice developed more severe beta cell dysfunction and glucose intolerance on high fat diet, along with increased ROS levels and decreased islet mitochondrial mass.	ros	156-159	endothelial PAS domain protein 1	Mus musculus	30-40
27529477-10	2016	We conclude that 1) normal cardiac performance requires basal NOS-1 activity and S-nitrosylation of the calcium-cycling machinery; 2) beta-adrenergic stimulation induces rapid and reversible NOS-1 dependent, PKA and ROS-dependent, S-nitrosylation of RyR2 and other proteins, accounting for about one third of its inotropic effect.	ros	216-219	nitric oxide synthase 1	Rattus norvegicus	191-196
35468924-7	2022	Furthermore, TLR4 and SARM1 modulated ROS production, which was induced by cell death in response to cisplatin.	ros	38-41	toll like receptor 4	Homo sapiens	13-17
35460064-12	2022	Under the stimulation of oxidative stress, telomerase catalytic subunit TERT mainly plays an inhibitory role on oxidative stress, reduces the production of ROS and protects telomere function.	ros	156-159	telomerase reverse transcriptase	Homo sapiens	72-76
27527552-6	2016	NAC can completely restore the decreased cell viability of MGC-803 cells caused by by241, suggesting ROS-mediated mechanisms.	ros	101-104	X-linked Kx blood group	Homo sapiens	0-3
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	ros	74-77	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	270-293
27493727-7	2016	Finally, we show that the PC activity of K562 cells exclusively fuels the ROS-induced decarboxylation of oxaloacetate to malonate in response to BaP treatment; resulting in further Krebs cycle disruption via depletion of oxaloacetate and malonate-mediated inhibition of succinate dehydrogenase (SDH) resulting in a twofold reduction of fumarate.	ros	74-77	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	295-298
31150806-0	2019	Arsenic inhibited cholesterol efflux of THP-1 macrophages via ROS-mediated ABCA1 hypermethylation.	ros	62-65	ATP binding cassette subfamily A member 1	Homo sapiens	75-80
31150806-5	2019	Results showed that arsenic could induce ROS-mediated DNA methyltransferase 1 (DNMT1) transcription and activity up-regulation, causing ABCA1 promoter to be hypermethylated with repressed expression.	ros	41-44	DNA methyltransferase 1	Homo sapiens	54-77
31150806-5	2019	Results showed that arsenic could induce ROS-mediated DNA methyltransferase 1 (DNMT1) transcription and activity up-regulation, causing ABCA1 promoter to be hypermethylated with repressed expression.	ros	41-44	DNA methyltransferase 1	Homo sapiens	79-84
31150806-5	2019	Results showed that arsenic could induce ROS-mediated DNA methyltransferase 1 (DNMT1) transcription and activity up-regulation, causing ABCA1 promoter to be hypermethylated with repressed expression.	ros	41-44	ATP binding cassette subfamily A member 1	Homo sapiens	136-141
35421237-10	2022	ROS and iron accumulation enhances the susceptibility of ME1 null cells to ferroptosis induction with inhibitors of xCT (erastin and ACXT-3102).	ros	0-3	solute carrier family 7 member 11	Homo sapiens	116-119
31150806-8	2019	All of the findings suggest that arsenic inhibit cholesterol efflux of THP-1 macrophages via ROS-mediated ABCA1 hypermethylation.	ros	93-96	ATP binding cassette subfamily A member 1	Homo sapiens	106-111
27385218-0	2016	SEP enhanced the antitumor activity of 5-fluorouracil by up-regulating NKG2D/MICA and reversed immune suppression via inhibiting ROS and caspase-3 in mice.	ros	129-132	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-3
27385218-8	2016	Moreover, in H22- or Lewis lung cancer (LLC)-bearing mouse models, SEP reversed 5-FU-induced atrophy and apoptosis in both the spleen and bone marrow in vivo by suppressing ROS generation and caspase-3 activation.	ros	173-176	epoxide hydrolase 2, cytoplasmic	Mus musculus	67-70
35456967-10	2022	Furthermore, when Pgk1 was added to the culture medium for culturing dopamine-like SH-SY5Y cells, it could reduce the ROS pathway and apoptosis caused by the neurotoxin MPP+.	ros	118-121	phosphoglycerate kinase 1	Homo sapiens	18-22
30634049-5	2019	Didymin also attenuated the VEGF-induced generation of ROS, activation of NF-kappaB and the expression of adhesion molecules such as VCAM-1, ICAM-1, and E-selectin in HUVECs.	ros	55-58	vascular endothelial growth factor A	Mus musculus	28-32
34968619-6	2022	However, NAC treatment could partly reverse the reduction of FTO expression as well as the degree of ROS via eliminating oxidative stress.	ros	101-104	X-linked Kx blood group	Homo sapiens	9-12
35474765-7	2022	ROS-induced DNA DSBs get repaired in HCT116 cells, in which CHEK2 is in the normal functional state, but these DNA DSBs persist in CHEK2-null HCT116 cells as confirmed by the immunofluorescence analysis of 53BP1 and gamma-H2AX.	ros	0-3	tumor protein p53 binding protein 1	Homo sapiens	206-211
35218740-10	2022	Taken together, the present study indicates that CORM-2-induced Nrf2/HO-1 alleviates IL-6/Jak2/Stat3-mediated inflammatory responses to Ang II by inhibiting NADPH oxidase- and mitochondria-derived ROS, suggesting that CORM-2 is a promising pharmacologic candidate to reverse the pathological changes involved in the inflammation of vessel wall for the prevention and treatment of AAA.	ros	197-200	heme oxygenase 1	Homo sapiens	69-73
34695464-10	2022	The western blot assay showed a ROS-mediated mitochondrial apoptosis signaling pathway was activated after exposure to 4TTR in neonatal rat cardiomyocytes (NRCMs).	ros	32-35	transthyretin	Rattus norvegicus	120-123
27279484-0	2016	Role of Nox4 and p67phox subunit of Nox2 in ROS production in response to increased tubular flow in the mTAL of Dahl salt-sensitive rats.	ros	44-47	cytochrome b-245 beta chain	Rattus norvegicus	36-40
35464170-1	2022	PBX1 expression has been found to be significantly reduced in nigrostriatal neurons of PD patients, but the effect of PBX1 on ROS and apoptosis in nigrostriatal dopamine neurons is not yet known.	ros	126-129	PBX homeobox 1	Homo sapiens	118-122
34601007-5	2022	rCfl1, Cfl19-25, Cfl134-51, and Cfl1108-125 were all able to cause bacterial cell destruction, to induce membrane depolarization, and to stimulate intracellular ROS production.	ros	161-164	cofilin 1	Rattus norvegicus	0-5
35007698-4	2022	This review briefly summarizes the T cell metabolic profiles and key metabolic challenges it faces in TME such as nutrient depletion, hypoxia, and toxic metabolites, then emphatically discusses the potential strategies to modulate metabolic properties of CAR-T cells including improving CARs construct design, optimizing manufacture process via addition of exogenous cytokines or targeting specific signaling pathway, manipulating ROS levels balance or relieve the unfavorable metabolic TME including adaptation to hypoxia and relieving inhibitory effect of toxic metabolites, eventually strengthening the anti-tumor response.	ros	431-434	CXADR pseudogene 1	Homo sapiens	255-258
26486797-6	2016	Strikingly, the supplement of inhibitors, including NAC (ROS), PDTC (NF-kappaB), or WP1066 (STAT3), contributed to a decline in leukemia cell growth.	ros	57-60	X-linked Kx blood group	Homo sapiens	52-55
34767921-13	2022	In conclusion, TMAO can aggravate hyperoxaluria-induced kidney injury by triggering the PERK/ROS pathway, which enhances autophagy, apoptosis and inflammation, and facilitates CaOx crystal deposition in renal tubular cells.	ros	93-96	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	88-92
35353897-16	2022	These findings reveal a novel HBx regulatory HMGA2/STC2 pathway in counteracting ROS-induced cell death.	ros	81-84	X protein	Hepatitis B virus	30-33
34875574-8	2022	LPS, PGN, and MDP induced FM IL-1beta and IL-18 secretion in a non-pyroptotic manner through activation of the NLRP3 inflammasome with contributions from ATP release through Pannexin-1, and ROS signaling.	ros	190-193	interleukin 18	Homo sapiens	42-47
25689151-8	2016	Other effects of CERP were stimulation of ROS and Ca(2+) , mitochondria impairment, and activation of caspase-3, -8, and -9.	ros	42-45	ATP binding cassette subfamily A member 1	Homo sapiens	17-21
35353897-16	2022	These findings reveal a novel HBx regulatory HMGA2/STC2 pathway in counteracting ROS-induced cell death.	ros	81-84	high mobility group AT-hook 2	Homo sapiens	45-50
35302183-10	2022	Overall, these results indicate that SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-alpha upregulation in HQ-treated U937 cells.	ros	121-124	ELAV like RNA binding protein 1	Homo sapiens	69-72
34929501-11	2022	CONCLUSIONS: The findings of this study suggested that COF-PM2.5 exposure could contribute to intrauterine growth restriction through disturbing the ROS/eNOS/ET-1 axis, while VitD3 supplementation could be an effective prophylactic measurement.	ros	149-152	nitric oxide synthase 3	Rattus norvegicus	153-157
35074406-0	2022	HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis.	ros	81-84	piwi like RNA-mediated gene silencing 4	Homo sapiens	0-5
35074406-8	2022	Overexpression of HIWI2 in HT1080 cells causes DNA damage by increasing intracellular ROS by inhibiting the expression of antioxidant genes (SOD1, SOD2, GPX1, GPX4, and CAT).	ros	86-89	piwi like RNA-mediated gene silencing 4	Homo sapiens	18-23
34967938-7	2021	RESULTS: Administration of Klotho protein resulted in mitigation of injury, decreased level of NOX2 and NOX4, reduced generation of ROS/RNS and hydrogen peroxide (H2O2), decreased expression of inducible NOS and limited production of nitrates/nitrites in cells under I/R.	ros	132-135	klotho	Homo sapiens	27-33
35074406-11	2022	SIGNIFICANCE: These results are the first to show that HIWI2 acts as a tumor suppressor in fibrosarcoma by modulating the ROS/DNA damage/p53 pathway.	ros	122-125	piwi like RNA-mediated gene silencing 4	Homo sapiens	55-60
34969963-6	2021	Triacontanol performs as a good scavenger of ROS by accelerating the activity of antioxidant enzymes (SOD, POD, CAT) and compatible solutes (proline, glycinebetaine, phenolic contents), which lead to improved gas exchange attributes and water relations and in that way enhance the calcium and potassium contents or decline the sodium and chloride contents in cucumber leaves.	ros	45-48	catalase isozyme 1	Cucumis sativus	112-115
34968686-6	2022	We show that activated GPR84 induces Galpha15-dependent ERK activation, increases intracellular Ca2+ and IP3 levels as well as ROS production.	ros	127-130	G protein-coupled receptor 84	Homo sapiens	23-28
35298964-4	2022	miR-21 is a potential biomarker of cervical cancer, which can induce apoptosis through ROS regulated the mitochondrial pathway of cells.	ros	87-90	microRNA 21	Homo sapiens	0-6
34940612-8	2021	This protective effect is SUCNR1-independent and mediated by reduced mitochondrial fission and cellular ROS production.	ros	104-107	succinate receptor 1	Homo sapiens	26-32
35414789-0	2022	Yap is essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.	ros	62-65	ribonucleotide reductase regulatory subunit M2	Homo sapiens	53-57
35414789-10	2022	Collectively, Yap was essential for uterine decidualization through Rrm2/GSH/ROS pathway in response to Bmp2.	ros	77-80	ribonucleotide reductase regulatory subunit M2	Homo sapiens	68-72
35245456-5	2022	Whether inside the "producer" IDO1+ cell or the "receiver" cell, KYN is converted into downstream metabolites, suppressing ferroptosis by ROS scavenging and activating an NRF2-dependent, AHR-independent cell-protective pathway, including SLC7A11, propagating anti-ferroptotic signaling.	ros	138-141	indoleamine 2,3-dioxygenase 1	Homo sapiens	30-34
34885250-4	2021	shRNA-mediated loss of ATG3 impaired autophagy function in AML cells and increased their mitochondrial activity and energy metabolism, as shown by elevated mitochondrial ROS generation and mitochondrial respiration.	ros	170-173	autophagy related 3	Homo sapiens	23-27
34836491-6	2021	Nor was RA-induced upregulation of p-tyr phosphorylation of p47phox, a member of the NADPH complex that produces ROS, a putative phosphorylation dependent signaling regulator.	ros	113-116	neutrophil cytosolic factor 1	Homo sapiens	60-67
34884817-0	2021	Transcriptomics Reveals the ERF2-bHLH2-CML5 Module Responses to H2S and ROS in Postharvest Calcium Deficiency Apples.	ros	72-75	transcription factor MYC2	Malus domestica	33-38
35196483-4	2022	The ROS-dependent TRAF6-mediated non-proteolytic, K48/63-linked ubiquitination of ATG9A enhances its association with Beclin 1 and the assembly of VPS34-UVRAG complex, thereby stimulating autophagy.	ros	4-7	TNF receptor associated factor 6	Homo sapiens	18-23
34390123-6	2021	Combinational treatment of elesclomol and copper leads to copper retention within mitochondria due to ATP7A loss, leading to ROS accumulation, which in turn promotes the degradation of SLC7A11, thus further enhancing oxidative stress and consequent ferroptosis in CRC cells.	ros	125-128	ATPase copper transporting alpha	Homo sapiens	102-107
35196483-6	2022	We further find that lipopolysaccharide (LPS)-induced ROS production also stimulates TRAF6-mediated ATG9A ubiquitination.	ros	54-57	TNF receptor associated factor 6	Homo sapiens	85-90
35216470-5	2022	The mechanism for MET-dependent cytotoxicity on C32 cells was found at the level of PRODH/POX-induced ROS generation and activation of Caspase-3 and Caspase-9 expressions in these cells.	ros	102-105	proline dehydrogenase 1	Homo sapiens	90-93
34562609-5	2021	In human corneal epithelial cells (HCE-2), NaOH treatment induced mitochondrial fission, intracellular ROS production and mitochondrial membrane potential disruption, which was prevented by Drp1 inhibitor Mdivi-1.	ros	103-106	utrophin	Homo sapiens	190-194
34562609-6	2021	In corneas, Mdivi-1 or knockdown of Drp1 by Lenti-Drp1 shRNA attenuated alkali burn-induced ROS production and phosphorylation of IkappaBalpha and p65.	ros	92-95	utrophin	Homo sapiens	36-40
34562609-6	2021	In corneas, Mdivi-1 or knockdown of Drp1 by Lenti-Drp1 shRNA attenuated alkali burn-induced ROS production and phosphorylation of IkappaBalpha and p65.	ros	92-95	utrophin	Homo sapiens	50-54
35216470-9	2022	It has been found that the underlying mechanism of anticancer activity of MET involves the activation of AMPK, PRODH/POX, increase in the cytoplasmic concentration of proline, inhibition of collagen biosynthesis, and stimulation of PRODH/POX-dependent ROS generation, which initiate the apoptosis of melanoma cells.	ros	252-255	SAFB like transcription modulator	Homo sapiens	74-77
35144642-8	2022	Activated ROS-metabolism was identified in METTL7B-overexpressed LUAD cells, accompanied with upregulated protein level of GPX4, HMOX1 and SOD1 and their enzymatic activities.	ros	10-13	heme oxygenase 1	Homo sapiens	129-134
35159102-4	2022	The results from cellular experiments and a xenograft-bearing mice model indicated that ATP8B1 knockdown firstly induced mitochondrial dysfunction and promoted ROS production.	ros	160-163	ATPase, class I, type 8B, member 1	Mus musculus	88-94
34849103-10	2021	Myocardial mitochondrial injuries were ameliorated by CAP activation, including the reserved ultrastructural integrity, declining ROS overload, reduced myocardial apoptosis, and enhanced mitochondrial fusion.	ros	130-133	sorbin and SH3 domain containing 1	Rattus norvegicus	54-57
35115498-6	2022	Bdh1 knockdown led to ROS overproduction and ROS-induced inflammation and apoptosis in LO2 cells, while Bdh1 overexpression protected LO2 cells from lipotoxicity by inhibiting ROS overproduction.	ros	22-25	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	0-4
34829268-8	2021	Treatment with ROS or antifungal compounds reduced survival of ddr48  yeasts compared to controls, consistent with an aberrant cellular stress response.	ros	15-18	DNA damage-responsive protein 48	Saccharomyces cerevisiae S288C	63-68
34743684-6	2021	ELOVL6 and ELOVL7 are sensitive to ROS induced depletion of cellular NADPH and insufficient regeneration via the pentose phosphate pathway and mitochondrial fatty acid oxidation.	ros	35-38	ELOVL fatty acid elongase 7	Homo sapiens	11-17
35115498-6	2022	Bdh1 knockdown led to ROS overproduction and ROS-induced inflammation and apoptosis in LO2 cells, while Bdh1 overexpression protected LO2 cells from lipotoxicity by inhibiting ROS overproduction.	ros	45-48	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	0-4
35115498-6	2022	Bdh1 knockdown led to ROS overproduction and ROS-induced inflammation and apoptosis in LO2 cells, while Bdh1 overexpression protected LO2 cells from lipotoxicity by inhibiting ROS overproduction.	ros	45-48	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	104-108
35115498-6	2022	Bdh1 knockdown led to ROS overproduction and ROS-induced inflammation and apoptosis in LO2 cells, while Bdh1 overexpression protected LO2 cells from lipotoxicity by inhibiting ROS overproduction.	ros	176-179	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	104-108
35115498-7	2022	Mechanistically, Bdh1-mediated betaOHB metabolism inhibits ROS overproduction by activation of Nrf2 through enhancement of metabolic flux composed of betaOHB-AcAc-succinate-fumarate.	ros	59-62	3-hydroxybutyrate dehydrogenase 1	Homo sapiens	17-21
34732698-5	2021	On the one hand, fasting-induced mTOR inhibition reduces unnecessary ATP consumption and increases ATP reserves under acute hypoxia as a result of decreased protein synthesis and lipogenesis; on the other hand, fasting-induced mTOR inhibition improves mitochondrial oxygen utilization efficiency to ensure ATP production under acute hypoxia, which is due to the significant decrease in ROS generation induced by enhanced mitophagy.	ros	386-389	mechanistic target of rapamycin kinase	Rattus norvegicus	33-37
35573641-0	2022	Baicalin induces apoptosis and autophagy in human osteosarcoma cells by increasing ROS to inhibit PI3K/Akt/mTOR, ERK1/2 and beta-catenin signaling pathways.	ros	83-86	catenin beta 1	Homo sapiens	124-136
34732698-5	2021	On the one hand, fasting-induced mTOR inhibition reduces unnecessary ATP consumption and increases ATP reserves under acute hypoxia as a result of decreased protein synthesis and lipogenesis; on the other hand, fasting-induced mTOR inhibition improves mitochondrial oxygen utilization efficiency to ensure ATP production under acute hypoxia, which is due to the significant decrease in ROS generation induced by enhanced mitophagy.	ros	386-389	mechanistic target of rapamycin kinase	Rattus norvegicus	227-231
35090371-0	2022	Negative feedback system to maintain cell ROS homeostasis KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy.	ros	42-45	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	64-69
34343634-9	2021	Moreover, RRP15 depletion in p53-mutant PLC5 and p53-deleted Hep3B cells induced metabolic shift from the glycolytic pentose-phosphate to mitochondrial oxidative phosphorylation via regulating a series of key genes such as HK2 and TIGAR, and thus, promoted the generation of ROS and apoptosis.	ros	275-278	ribosomal RNA processing 15 homolog	Homo sapiens	10-15
34832853-6	2021	Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA-AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFkappaB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells.	ros	60-63	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	158-163
34832853-6	2021	Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA-AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFkappaB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells.	ros	60-63	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	165-170
34832853-6	2021	Collectively, our data indicated that high-glucose-mediated ROS production was reduced upon cell treatment with GA-AuNPs, which blocked p38 MAPK/ERK-mediated c-Jun, c-Fos, ATF-2 phosphorylation, and the phosphorylation of NFkappaB, leading to the down-regulation of MMP-1 mRNA and protein expression in high glucose-treated cells.	ros	60-63	activating transcription factor 2	Homo sapiens	172-177
35090371-0	2022	Negative feedback system to maintain cell ROS homeostasis KEAP1-PGAM5 complex senses mitochondrially generated ROS to induce mitophagy.	ros	111-114	PGAM family member 5, mitochondrial serine/threonine protein phosphatase	Homo sapiens	64-69
34560818-8	2021	Changes in miR-24 and Prdx6 levels were associated with altered mitochondrial ROS generation, increase in the DNA damage marker: phosphorylated-H2Ax and changes in viability, senescence, and myogenic potential of myogenic progenitors from mice and humans.	ros	78-81	microRNA 24-1	Mus musculus	11-17
34560818-10	2021	We propose that downregulation of miR-24 and subsequent upregulation of Prdx6 in muscle of old mice following injury are an adaptive response to aging, to maintain satellite cell viability and myogenic potential through regulation of mitochondrial ROS and DNA damage pathways.	ros	248-251	microRNA 24-1	Mus musculus	34-40
35009000-9	2022	Further research found that heat stress could increase H2O2 content in lily leaves and reduced H2O2 accumulation in transgenic plants, which was consistent with the up-regulation of HSR downstream genes such as Heat stress proteins (HSPs), Galactinol synthase1 (GolS1), WRKY DNA binding protein 30 (WRKY30), Zinc finger of Arabidopsis thaliana 6 (ZAT6) and the ROS-scavenging enzyme Ascorbate peroxidase 2 (APX2).	ros	361-364	galactinol synthase 1	Arabidopsis thaliana	240-260
34599149-2	2021	Here, we report that the NUPR1 inhibitor ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents.	ros	57-60	nuclear protein transcription regulator 1	Mus musculus	25-30
34599149-2	2021	Here, we report that the NUPR1 inhibitor ZZW-115 induces ROS accumulation followed by a ferroptotic cell death, which could be prevented by ferrostatin-1 (Fer-1) and ROS-scavenging agents.	ros	166-169	nuclear protein transcription regulator 1	Mus musculus	25-30
34428586-8	2021	Additionally, mutation of the SUMOylation sites of SERCA2a blocked the positive effect of Rg3 on the ISO-induced abnormal Ca2+ cycle in HL-1 cells, and was accompanied by an abnormal endoplasmic reticulum stress response and generation of ROS.	ros	239-242	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2	Mus musculus	51-58
34399087-7	2021	DEX blocked glucose uptake by downregulating GRalpha expression, which reduced GLUT1 and GLUT3 mRNA and protein expression, which, in turn, may have inhibited the PI3K/AKT/mTOR pathway and activated the ROS/AMPK pathway.	ros	203-206	solute carrier family 2 member 3	Homo sapiens	89-94
34478853-13	2021	The results indicated that prenatal toxic factor hypoxia resulted in abnormal ETBR activation, which enhanced ET-1-mediated vasoconstriction of pulmonary arteries and pulmonary artery smooth muscle cell proliferation through ETBR/Nox1/4-derived ROS pathway.	ros	245-248	NADPH oxidase 1	Rattus norvegicus	230-234
34479089-6	2021	Mechanistically, DOX stimulation led to excessive accumulation of ROS, which activated the NF-kappaB-Snail pathway and resulted in EndMT.	ros	66-69	snail family zinc finger 1	Mus musculus	101-106
34559194-10	2021	Despite enhanced ROS levels within the local inflammatory milieu, JIA T cells are hyperproliferative and reveal an overexpression of miR-23a, which is an inhibitor of PPIF, the regulator of mitochondrial ROS escape.	ros	204-207	microRNA 23a	Homo sapiens	133-140
34671210-11	2021	Wnt/beta-catenin-Cyp2e1 signaling together with ROS generation could be exacerbated by the overexpression of Lrp6, while decreased in response to Lrp6 siRNA or silibinin treatment under NAFLD modeling.	ros	48-51	low density lipoprotein receptor-related protein 6	Mus musculus	109-113
34671210-11	2021	Wnt/beta-catenin-Cyp2e1 signaling together with ROS generation could be exacerbated by the overexpression of Lrp6, while decreased in response to Lrp6 siRNA or silibinin treatment under NAFLD modeling.	ros	48-51	low density lipoprotein receptor-related protein 6	Mus musculus	146-150
34577000-8	2021	Further apoptosis induction, caspase activation, and ROS generation in rutin-treated SiHa cancer cells explain the cascade of events associated with Jab1 downregulation in SiHa cancer cells.	ros	53-56	COP9 signalosome subunit 5	Homo sapiens	149-153
34298057-5	2021	In vitro results showed that PM/TN-CCLP exhibited low cytotoxicity and elevated cellular uptake by inflammatory macrophages, and prominently inhibited the transendothelial migration, inflammatory responses and ROS generation of macrophages.	ros	210-213	C-type lectin domain family 3, member b	Mus musculus	32-34
34557417-0	2021	Corrigendum: Targeting ACLY Attenuates Tumor Growth and Acquired Cisplatin Resistance in Ovarian Cancer by Inhibiting the PI3K-AKT Pathway and Activating the AMPK-ROS Pathway.	ros	163-166	ATP citrate lyase	Homo sapiens	23-27
34216418-6	2021	Furthermore, LC activated Nrf2 signaling by binding to Keap1 to reverse the striking DON-induced increase in ROS levels.	ros	109-112	kelch-like ECH-associated protein 1	Mus musculus	55-60
34318860-7	2021	Glucose oxidase (GOx) elevated the gluconic acid ROS levels in tumor cells, resulting in an acidic and oxidative environment.	ros	49-52	hydroxyacid oxidase 1	Homo sapiens	0-15
34318860-7	2021	Glucose oxidase (GOx) elevated the gluconic acid ROS levels in tumor cells, resulting in an acidic and oxidative environment.	ros	49-52	hydroxyacid oxidase 1	Homo sapiens	17-20
34631276-9	2021	Meanwhile, miR-320a increased the ROS level, inhibited proliferation, and induced apoptosis of cultured beta cells in vitro.	ros	34-37	microRNA 320a	Rattus norvegicus	11-19
34445601-8	2021	Mechanically, ferritin heavy chain 1 (Fth), the ferroxidase function to oxidate redox-active Fe2+ to redox-inactive Fe3+, is likely responsible for the hypersensitivity of N2A to ferroptosis induction since its expression is lower in N2A compared to NSCs; ectopic expression of Fth reduces ROS levels and cell death, and induces expression of GPX4 and cell viability in N2A cells.	ros	290-293	ferritin heavy polypeptide 1	Mus musculus	14-36
34445601-8	2021	Mechanically, ferritin heavy chain 1 (Fth), the ferroxidase function to oxidate redox-active Fe2+ to redox-inactive Fe3+, is likely responsible for the hypersensitivity of N2A to ferroptosis induction since its expression is lower in N2A compared to NSCs; ectopic expression of Fth reduces ROS levels and cell death, and induces expression of GPX4 and cell viability in N2A cells.	ros	290-293	ferritin heavy polypeptide 1	Mus musculus	38-41
34445601-8	2021	Mechanically, ferritin heavy chain 1 (Fth), the ferroxidase function to oxidate redox-active Fe2+ to redox-inactive Fe3+, is likely responsible for the hypersensitivity of N2A to ferroptosis induction since its expression is lower in N2A compared to NSCs; ectopic expression of Fth reduces ROS levels and cell death, and induces expression of GPX4 and cell viability in N2A cells.	ros	290-293	ferritin heavy polypeptide 1	Mus musculus	278-281
34422206-3	2021	In vitro exposure of H9C2 rat cardiomyocytes to hypoxia/reoxygenation (H/R) augmented mitochondrial ROS synthesis, suppressed both mitochondrial potential and ATP generation, and increased the mitochondrial permeability transition pore (mPTP) opening rate.	ros	100-103	HR, lysine demethylase and nuclear receptor corepressor	Rattus norvegicus	71-74
34344968-5	2021	Moreover, IL-18 increased calcium influx into neutrophils, which led to mitochondrial ROS (mROS) production and NETs formation.	ros	86-89	interleukin 18	Homo sapiens	10-15
34112953-0	2021	Correction: IQGAP1 promotes anoikis resistance and metastasis through Rac1-dependent ROS accumulation and activation of Src/FAK signalling in hepatocellular carcinoma.	ros	85-88	Rac family small GTPase 1	Homo sapiens	70-74
34229586-4	2021	Then, the PRP-derived exosomes (PRP-exo) were isolated and purified, and we noticed that both PRP-exo and ROS scavenger (NAC) reversed the detrimental effects of H2O2 treatment on the nucleus pulposus (NP) cells.	ros	106-109	NLR family, pyrin domain containing 1A	Mus musculus	121-124
34351541-8	2021	CONCLUSION: Taken together, these data suggested that the simultaneous modification of homologous gene copies of WRKY are established using CRISPR/Cas9 system in A. thaliana and the loss of AtWRKY3 and AtWRKY4 has an effect on ROS scavenging pathways to reduce stress tolerance.	ros	227-230	WRKY DNA-binding protein 3	Arabidopsis thaliana	190-197
34160527-5	2021	With efficient ROS generation, excellent biocompatibility, two-photon imaging capability, and depth imaging (21 mum in vitro and 210 mum in vivo), TTR can effectively kill tumor cells and inhibit the growth of subcutaneous tumors.	ros	15-18	transthyretin	Homo sapiens	147-150
34336093-6	2021	Mitochondrial functions of the MT-ND2 m. 5178C>A mutant lymphocyte were increased, including increased ATP synthesis, decreased ROS production, increased mitochondrial membrane potential and Bcl-2 gene transcription and protein translation, decreased Caspase 3/7 activity, and decreased early apoptosis and late apoptosis.	ros	128-131	mitochondrially encoded NADH dehydrogenase 2	Homo sapiens	31-37
34203664-9	2021	Here, we show that Flt3-ITD+ cells are sensitive to an IB-induced dynamin 1-like (Drp1)-p38-ROS pathway.	ros	92-95	LOC107987471	Homo sapiens	66-80
34060394-5	2022	Moreover, this agent induced ROS-mediated apoptosis by altering the expression of Bax, Bim, Caspase3, Bcl2, and XIAP.	ros	29-32	X-linked inhibitor of apoptosis	Homo sapiens	112-116
34084175-0	2021	Canonical Secretomes, Innate Immune Caspase-1-, 4/11-Gasdermin D Non-Canonical Secretomes and Exosomes May Contribute to Maintain Treg-Ness for Treg Immunosuppression, Tissue Repair and Modulate Anti-Tumor Immunity via ROS Pathways.	ros	219-222	gasdermin D	Mus musculus	53-64
35504386-0	2022	Suppression of NADPH oxidase 4 inhibits PM2.5-induced cardiac fibrosis through ROS-P38 MAPK pathway.	ros	79-82	NADPH oxidase 4	Rattus norvegicus	15-30
35504386-13	2022	In summary, the current study provided evidence that PM2.5 challenge led to cardiac fibrosis through oxidative stress, systemic inflammation, and subsequent TGFbeta/NOX4/ROS/P38 MAPK pathway and may offer new therapeutic targets in cardiac fibrosis.	ros	170-173	transforming growth factor alpha	Rattus norvegicus	157-164
35504386-13	2022	In summary, the current study provided evidence that PM2.5 challenge led to cardiac fibrosis through oxidative stress, systemic inflammation, and subsequent TGFbeta/NOX4/ROS/P38 MAPK pathway and may offer new therapeutic targets in cardiac fibrosis.	ros	170-173	NADPH oxidase 4	Rattus norvegicus	165-169
35585170-0	2022	In utero hypoxia attenuated acetylcholine-mediated vasodilatation via CHRM3/p-NOS3 in fetal sheep MCA: role of ROS/ERK1/2.	ros	111-114	muscarinic acetylcholine receptor M3	Ovis aries	70-75
35367811-6	2022	XBP1 deficiency increased ROS production to promote hepatocellular pyroptosis by activating NLRP3/caspase-1/GSDMD signaling, which facilitated the extracellular release of mtDNA.	ros	26-29	gasdermin D	Mus musculus	108-113
35629435-10	2022	From bedside to bench, ROS scavenger attenuates PCS-activated expressions of cPLA2/COX2, pro-caspase-1 and NLRP3 in the HASMC model.	ros	23-26	phospholipase A2 group IVA	Homo sapiens	77-82
35613681-9	2022	NAC, a well-known commercial antioxidant, alleviated 1-NP-induced excessive ROS and oxidative stress.	ros	76-79	NLR family, pyrin domain containing 1A	Mus musculus	0-3
35597445-4	2022	DC3000D36E that harbors each effector suppresses FliC-triggered Pti5 and ACRE31 expression, ROS burst, and callose deposition.	ros	92-95	flagellin	Pseudomonas syringae pv. tomato str. DC3000	49-53
35605404-4	2022	A53T transfection showed distinct increase in basal pSyn-129 expression with simultaneous nuclear localization, and CK2alpha siRNA decreased ROS-generation and pSyn-129 levels.	ros	141-144	casein kinase 2 alpha 2	Homo sapiens	116-124
35605404-7	2022	Thus, using CK2alpha siRNA to reduce phosphorylation improved cellular-pathology in terms of ROS generation and pSyn-129 levels, as well as functional performance of DA-neuronal cells.	ros	93-96	casein kinase 2 alpha 2	Homo sapiens	12-20
35501301-0	2022	A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis.	ros	117-120	serine and arginine rich splicing factor 3	Homo sapiens	8-13
35501301-0	2022	A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis.	ros	117-120	serine and arginine rich splicing factor 3	Homo sapiens	104-109
35501301-7	2022	The novel SRSF3 inhibitor SFI003 exhibits potent antitumor efficacy in vitro and in vivo, which drives apoptosis of CRC cells via the SRSF3/DHCR24/reactive oxygen species (ROS) axis.	ros	172-175	serine and arginine rich splicing factor 3	Homo sapiens	10-15
35501301-7	2022	The novel SRSF3 inhibitor SFI003 exhibits potent antitumor efficacy in vitro and in vivo, which drives apoptosis of CRC cells via the SRSF3/DHCR24/reactive oxygen species (ROS) axis.	ros	172-175	serine and arginine rich splicing factor 3	Homo sapiens	134-139
35499677-8	2022	Transgenic plants exhibited constitutive downregulation of the target NLRs, aggravated disease phenotype with an enhanced lesion, greater ROS generation and hypersusceptibility to A. solani infection, thus establishing that miR6024 negatively impacts plant immune response during necrotrophic pathogenesis.	ros	138-141	MIR6024	Solanum lycopersicum	224-231
27354147-17	2016	ACEI captopril could reduce the expression of MMP-9 mediated by ROS, then relieve cerebral edema and improve neurological function, which may lay a foundation for further basic research and clinical application.	ros	64-67	matrix metallopeptidase 9	Homo sapiens	46-51
27439459-7	2016	(3) The chloroplast ROS signaling marker genes ZAT10 and BAP1 were less activated by the triggering stimulus in primed plants.	ros	20-23	BON association protein 1	Arabidopsis thaliana	57-61
27385468-7	2016	Together, these data identify FOXM1 as a key regulator of ROS in normal dividing epithelial cells and suggest that squamous carcinoma cells may also use FOXM1 to control oxidative stress to escape premature senescence and apoptosis.	ros	58-61	forkhead box M1	Homo sapiens	30-35
27154302-7	2016	G-11 triggered generation of ROS, caused disruption of mitochondrial transmembrane potential, increased release of cytochrome c to the cytosol, and altered the expression of Bcl-2 and Bax proteins.	ros	29-32	serine/threonine kinase 19	Homo sapiens	0-4
27263444-5	2016	The self-assembled transferrin-IR780 nanoparticles (Tf-IR780 NPs) exhibited narrow size distribution, good photo-stability, and encouraging photothermal performance with enhanced generation of ROS under laser irradiation.	ros	193-196	transferrin	Mus musculus	19-30
26912410-8	2016	PAK2-inhibition protected acini from CCK-induced ROS-generation; caspase/trypsin-activation, important in early pancreatitis; as well as from cell-necrosis.	ros	49-52	cholecystokinin	Rattus norvegicus	37-40
26869262-1	2016	Superoxide dismutase (SOD) is believed to enhance abiotic stress resistance by converting superoxide radical (O2 (-)) to H2O2 to lower ROS level and maintain redox homeostasis.	ros	135-138	SOD	Triticum aestivum	0-20
26869262-1	2016	Superoxide dismutase (SOD) is believed to enhance abiotic stress resistance by converting superoxide radical (O2 (-)) to H2O2 to lower ROS level and maintain redox homeostasis.	ros	135-138	SOD	Triticum aestivum	22-25
26854718-8	2016	Further, inhibition of ROS with NAC not only rescued glioma cell necrosis but also suppressed JNK activation, mitigated Bax/Bcl-2 ratio, maintained mitochondrial membrane potential, and inhibited AIF translocation into nucleus.	ros	23-26	NLR family, pyrin domain containing 1A	Mus musculus	32-35
26854718-8	2016	Further, inhibition of ROS with NAC not only rescued glioma cell necrosis but also suppressed JNK activation, mitigated Bax/Bcl-2 ratio, maintained mitochondrial membrane potential, and inhibited AIF translocation into nucleus.	ros	23-26	mitogen-activated protein kinase 8	Mus musculus	94-97
26860957-5	2016	The increase in levels of inflammatory cytokines/chemokines corresponds to increased levels of ROS/RNS, which is accompanied by increased activities of Akt, ERK1/2, tuberin, down regulation of 8-oxoG-DNA glycosylase (OGG1), and increase in 8-hydroxydeoxyguanosine (8-OHdG) accumulation in DNA.	ros	95-98	8-oxoguanine DNA-glycosylase 1	Mus musculus	217-221
26974158-5	2016	In murine models of induced AAA, germline deletion of Ccn3 resulted in severe phenotypes characterized by elastin fragmentation, vessel dilation, vascular inflammation, dissection, heightened ROS generation, and smooth muscle cell loss.	ros	192-195	cellular communication network factor 3	Mus musculus	54-58
27029354-6	2016	In particular, the phosphorylation of MPK6, which is involved in regulating ROS responses under abiotic stresses, was disrupted in the SnRK1.1 (K48M) mutant.	ros	76-79	MAP kinase 6	Arabidopsis thaliana	38-42
27065868-0	2016	Sphingosine 1-Phosphate-Induced ICAM-1 Expression via NADPH Oxidase/ROS-Dependent NF-kappaB Cascade on Human Pulmonary Alveolar Epithelial Cells.	ros	68-71	intercellular adhesion molecule 1	Homo sapiens	32-38
26919094-5	2016	In this study, we demonstrate that B19 directly inhibits TrxR1 enzyme activity to elevate oxidative stress and then induce ROS-mediated ER Stress and mitochondrial dysfunction, subsequently resulting in cell cycle arrest and apoptosis in human gastric cancer cells.	ros	123-126	thioredoxin reductase 1	Homo sapiens	57-62
27004848-9	2016	Salusin-beta increased miR155 expression, and knockdown of miR155 prevented the effects of salusin-beta on ACAT-1 and VCAM-1 expressions, p65-NFkappaB nuclear translocation, lipid accumulation, monocyte adhesion and ROS production in VSMCs.	ros	216-219	microRNA 155	Homo sapiens	59-65
28219860-0	2016	[Salidroside protects PC12 cells from H2O2-induced apoptosis via suppressing NOX2-ROS-MAPKs signaling pathway].	ros	82-85	cytochrome b-245 beta chain	Rattus norvegicus	77-81
25417049-7	2016	The decrease in sdhc and sdhd expression was associated with a significant decrease in complex II activity and increase in mitochondrial levels of ROS.	ros	147-150	succinate dehydrogenase complex subunit C	Homo sapiens	16-20
25417049-8	2016	Overexpression of sdhc and sdhd suppressed 4-ClBQ-induced inhibition of complex II activity, increase in mitochondrial levels of ROS, and toxicity.	ros	129-132	succinate dehydrogenase complex subunit C	Homo sapiens	18-22
26820738-2	2016	Previously, we have reported a novel oncogenic role of PTGR2 in gastric cancer, where PTGR2 was discovered to modulate ROS-mediated cell death and tumor transformation.	ros	119-122	prostaglandin reductase 2	Homo sapiens	55-60
26820738-2	2016	Previously, we have reported a novel oncogenic role of PTGR2 in gastric cancer, where PTGR2 was discovered to modulate ROS-mediated cell death and tumor transformation.	ros	119-122	prostaglandin reductase 2	Homo sapiens	86-91
26820738-5	2016	In vitro analyses showed that silencing of PTGR2 expression enhanced ROS production, suppressed pancreatic cell proliferation, and promoted cell death through increasing 15-keto-PGE2.	ros	69-72	prostaglandin reductase 2	Homo sapiens	43-48
26689625-12	2016	Inhibition of ROS generation by N-acetyl-l-cysteine (NAC) attenuated ZT-25-induced cell death and autophagy.	ros	14-17	X-linked Kx blood group	Homo sapiens	53-56
26963898-11	2016	These results indicated NOX2 may be involved in RyR2-induced ROS generation which mediated contusion-induced spinal cord injury.	ros	61-64	cytochrome b-245 beta chain	Rattus norvegicus	24-28
27119348-8	2016	Experimental inhibition of p66shc by siRNA suppressed GA-induced increase of ROS, decrease of oxygen consumption rate, MMP and cell viability, whilst suppressing GA-induced increase of apoptosis.	ros	77-80	src homology 2 domain-containing transforming protein C1	Mus musculus	27-33
26350264-0	2016	ROS-Induced CXCR4 Signaling Regulates Mantle Cell Lymphoma (MCL) Cell Survival and Drug Resistance in the Bone Marrow Microenvironment via Autophagy.	ros	0-3	C-X-C motif chemokine receptor 4	Homo sapiens	12-17
26350264-8	2016	Further analysis revealed novel mechanisms of ROS-induced CXCR4/SDF-1 signaling that stimulate autophagy formation in MCL cells for their survival.	ros	46-49	C-X-C motif chemokine receptor 4	Homo sapiens	58-63
26683309-6	2016	In vitro, cells treated with T-2/HT-2 showed reductions of GSH concentration and significant increases in LDH leakage, ALT/AST ROS, GSH-PX, SOD and CAT activities, MDA concentration, and expression of mRNA related to oxidative stress.	ros	127-130	solute carrier family 25 member 5	Homo sapiens	29-32
27047545-9	2016	These results suggested that NOX inhibition attenuates thyroid dysfunction induced by PCB in rats, presumably because of its role in preventing ROS generation and inhibiting the activation of NF-kappaB pathway.	ros	144-147	pyruvate carboxylase	Rattus norvegicus	86-89
26596215-11	2016	ROS scavenger (NAC) was employed to inhibit the ROS level.	ros	0-3	X-linked Kx blood group	Homo sapiens	15-18
26596215-11	2016	ROS scavenger (NAC) was employed to inhibit the ROS level.	ros	48-51	X-linked Kx blood group	Homo sapiens	15-18
26596215-18	2016	NAC reduced UVB-induced ROS generation and inhibited UVB-induced upregulation of lnc-GKN2-1:1 and lnc-CD1D-2:1.	ros	24-27	X-linked Kx blood group	Homo sapiens	0-3
27294204-3	2016	We found that overexpression of methionine sulfoxide reductase A (MsrA), an antioxidant enzyme that reverses protein methionine oxidation, attenuated ROS-augmented NF-kappaB activation in endothelial cells, in part, by protecting against the oxidation of methionine residues in the regulatory domain of calcium/calmodulin-dependent protein kinase II (CaMKII).	ros	150-153	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	303-349
27294204-3	2016	We found that overexpression of methionine sulfoxide reductase A (MsrA), an antioxidant enzyme that reverses protein methionine oxidation, attenuated ROS-augmented NF-kappaB activation in endothelial cells, in part, by protecting against the oxidation of methionine residues in the regulatory domain of calcium/calmodulin-dependent protein kinase II (CaMKII).	ros	150-153	calcium/calmodulin-dependent protein kinase II, beta	Mus musculus	351-357
26798426-3	2016	The balance effects of simvastatin to ROS and antioxidants enzymes network are most probably due to improved SOD functional activity, increase in GSH-Px, increase in HO-1 expression, and decrease of MDA generation.	ros	38-41	heme oxygenase 1	Oryctolagus cuniculus	166-170
27547294-9	2016	In addition, we demonstrated that the increase of FOXO1 nuclear translocation was associated with the increased expressions of antioxidant catalase and SOD2 and the attenuated expression of the ROS generation enzyme NOX4.	ros	194-197	NADPH oxidase 4	Rattus norvegicus	216-220
26656285-5	2015	By quantitation of cell viability, ROS production, [Ca(2+)]i, and protein identification, we showed that TRPM2 channel is required for ROS production and Ca(2+) increase induced by silica NPs through regulating NADPH oxidase activity in HEK293 cells.	ros	35-38	transient receptor potential cation channel subfamily M member 2	Homo sapiens	105-110
26656285-5	2015	By quantitation of cell viability, ROS production, [Ca(2+)]i, and protein identification, we showed that TRPM2 channel is required for ROS production and Ca(2+) increase induced by silica NPs through regulating NADPH oxidase activity in HEK293 cells.	ros	135-138	transient receptor potential cation channel subfamily M member 2	Homo sapiens	105-110
26656285-8	2015	Taken together, these findings demonstrate for the first time that TRPM2 channel acts as an oxidative stress sensor that plays a dual role in silica NPs-induced cytotoxicity by differentially regulating the NADPH oxidase activity and ROS generation.	ros	234-237	transient receptor potential cation channel subfamily M member 2	Homo sapiens	67-72
26514923-0	2015	Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-kB, and AP-1 pathways in human endothelial cells.	ros	58-61	matrix metallopeptidase 9	Homo sapiens	16-42
26514923-0	2015	Cadmium induces matrix metalloproteinase-9 expression via ROS-dependent EGFR, NF-kB, and AP-1 pathways in human endothelial cells.	ros	58-61	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	89-93
26915222-10	2015	Meanwhile, the intracellular ROS level declined along with the decrease of SOD activity.	ros	29-32	AT695_RS09750	Staphylococcus aureus	75-78
26504004-4	2015	Increases were observed both at the gene and protein levels and arose as a consequence of increased generation of ROS by CBD, and correlated with an increase in a number of HSP client proteins.	ros	114-117	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	173-176
26300487-6	2015	Additionally, downregulation of STIM2 not only inhibited Ca(2+) release from the endoplasmic reticulum (ER), but also reduced SOCE-mediated Ca(2+) influx, decreased mitochondrial Ca(2+), restored mitochondrial morphology and improved mitochondrial function, including MMP maintenance, ROS production and ATP synthesis.	ros	285-288	stromal interaction molecule 2	Homo sapiens	32-37
26528354-7	2015	PUFA-induced apoptosis of LoVo and RKO cells is mediated through a mitochondria-mediated pathway as evidenced by loss of mitochondrial membrane potential, generation of ROS, accumulation of intracellular Ca(2+), activation of caspase-9 and caspase-3, decreased ATP level and increase in the Bax/Bcl2 expression ratio.	ros	169-172	pumilio RNA binding family member 3	Homo sapiens	0-4
26143630-7	2015	Cardiac NLRP3 inflammasome was activated with elevated myocardial IL-1beta and IL-18 concentrations mediated by ROS over-production and TXNIP over-expression in MI dogs.	ros	112-115	NLR family pyrin domain containing 3	Canis lupus familiaris	8-13
26143630-10	2015	CONCLUSIONS: These data firstly demonstrated that cardiac NLRP3 inflammasome activation driven by cardiac ROS over-production and TXNIP up-expression resulted in impairment of the JAK2-STAT3 and insulin signaling pathways, leading to disorder of lipid metabolism in myocardial ischemic dogs through PPAR-alpha over-expression.	ros	106-109	NLR family pyrin domain containing 3	Canis lupus familiaris	58-63
26143630-10	2015	CONCLUSIONS: These data firstly demonstrated that cardiac NLRP3 inflammasome activation driven by cardiac ROS over-production and TXNIP up-expression resulted in impairment of the JAK2-STAT3 and insulin signaling pathways, leading to disorder of lipid metabolism in myocardial ischemic dogs through PPAR-alpha over-expression.	ros	106-109	Janus kinase 2	Canis lupus familiaris	180-184
26071548-3	2015	Disruption of frataxin has been found to induce mitochondrial iron overload and subsequent ROS production.	ros	91-94	frataxin	Mus musculus	14-22
26071548-9	2015	Our data also suggest that increased frataxin mitigated mitochondrial iron overload and subsequent ROS production, thus preserving mitochondrial membrane integrity and viability of cardiomyocytes.	ros	99-102	frataxin	Mus musculus	37-45
26133107-0	2015	Low-dose UVB irradiation prevents MMP2-induced skin hyperplasia by inhibiting inflammation and ROS.	ros	95-98	matrix metallopeptidase 2	Mus musculus	34-38
25917637-9	2015	Furthermore, up-regulation of NOD2 expression induced by T-2 toxin could be abrogated by pretreating the cells with inhibitors of NF-kappaB and scavenger of ROS.	ros	157-160	solute carrier family 25 member 5	Homo sapiens	57-60
25917637-10	2015	CONCLUSION: T-2 toxin could up-regulate NOD2 expression via ROS/NF-kappaB pathway and activate NOD2 signaling pathway.	ros	60-63	solute carrier family 25 member 5	Homo sapiens	12-15
26020803-6	2015	Overexpression of miR-155 caused inhibition of Foxo3a, leading to decrease of major antioxidants including SOD2 and catalase, and enhanced pancreatic cell proliferation induced by ROS generation.	ros	180-183	microRNA 155	Homo sapiens	18-25
26203587-14	2015	In addition, the quenching of ROS using NAC prevented the induction of JNK phosphorylation and CHOP induction.	ros	30-33	X-linked Kx blood group	Homo sapiens	40-43
26203587-15	2015	Furthermore, inhibition of ROS by NAC significantly attenuated TRAIL sensitization by TIIA.	ros	27-30	X-linked Kx blood group	Homo sapiens	34-37
26550302-2	2015	The underlying mechanisms of Abeta-induced neurotoxicity include generation of reactive oxidative species (ROS), inflammation, and neurons loss.	ros	107-110	amyloid beta precursor protein	Rattus norvegicus	29-34
26079889-3	2015	Noteworthy, we have previously demonstrated that EGFR/Rac1/reactive oxygen species (ROS)/matrix metalloproteinase 9 (MMP-9) is a key signaling cascade regulating MUC5AC production in airway cells challenged with LPS.	ros	84-87	Rac family small GTPase 1	Homo sapiens	54-58
26079889-3	2015	Noteworthy, we have previously demonstrated that EGFR/Rac1/reactive oxygen species (ROS)/matrix metalloproteinase 9 (MMP-9) is a key signaling cascade regulating MUC5AC production in airway cells challenged with LPS.	ros	84-87	matrix metallopeptidase 9	Homo sapiens	117-122
26079889-7	2015	This signaling pathway not only includes Rac1, ROS and MMP-9, but also NF-kappaB, since we have found that ROS require NF-kappaB activity to induce MMP-9 secretion and activation.	ros	47-50	matrix metallopeptidase 9	Homo sapiens	148-153
26079889-7	2015	This signaling pathway not only includes Rac1, ROS and MMP-9, but also NF-kappaB, since we have found that ROS require NF-kappaB activity to induce MMP-9 secretion and activation.	ros	107-110	Rac family small GTPase 1	Homo sapiens	41-45
26079889-7	2015	This signaling pathway not only includes Rac1, ROS and MMP-9, but also NF-kappaB, since we have found that ROS require NF-kappaB activity to induce MMP-9 secretion and activation.	ros	107-110	matrix metallopeptidase 9	Homo sapiens	55-60
26079889-7	2015	This signaling pathway not only includes Rac1, ROS and MMP-9, but also NF-kappaB, since we have found that ROS require NF-kappaB activity to induce MMP-9 secretion and activation.	ros	107-110	matrix metallopeptidase 9	Homo sapiens	148-153
35468040-6	2022	HFD-induced increase of beta-cell mitophagy is reduced by tfeb KO, leading to increased ROS and decreased mitochondrial complex activity or oxygen consumption in tfeb-KO islets.	ros	88-91	transcription factor EB	Mus musculus	58-62
35075596-7	2022	The stimulation of TRPM2 induced the increase of TRPM2 current densities, lipid peroxidation, cytosolic ROS, miROS, cytosolic Ca2+, and Zn2+ values in the Hep2 cells after the treatment of PAX, although their values were decreased by the treatment of MLT and TRPM2 antagonists (ACA and 2APB).	ros	104-107	transient receptor potential cation channel subfamily M member 2	Homo sapiens	19-24
35104550-4	2022	Moreover, the same treatment showed a marked upregulation in enzymes activity (APX, SOD, APX, and CAT) which oxidized the cell-damaging ROS, produced in response to As stress.	ros	136-139	superoxide dismutase	Zea mays	84-87
35566158-0	2022	Dictyophora Polysaccharide Attenuates As-Mediated PINK1/Parkin Pathway-Induced Mitophagy in L-02 Cell through Scavenging ROS.	ros	121-124	PTEN induced kinase 1	Homo sapiens	50-55
35566158-3	2022	In the present study, we demonstrated that As induced the onset of mitophagy in hepatocytes by stimulating cellular production of ROS to activate PINK1/Parkin, and the extent of damage increased with increased As-induced toxicity.	ros	130-133	PTEN induced kinase 1	Homo sapiens	146-151
35404404-6	2022	ABA-activated BAK1 phosphorylated AHA2 at Ser-944 in its C terminus and activated AHA2, leading to rapid H+ efflux, cytoplasmic alkalinization, and ROS accumulation, to initiate ABA signal transduction and stomatal closure.	ros	148-151	H[+]-ATPase 2	Arabidopsis thaliana	34-38
35404404-6	2022	ABA-activated BAK1 phosphorylated AHA2 at Ser-944 in its C terminus and activated AHA2, leading to rapid H+ efflux, cytoplasmic alkalinization, and ROS accumulation, to initiate ABA signal transduction and stomatal closure.	ros	148-151	H[+]-ATPase 2	Arabidopsis thaliana	82-86
35404404-7	2022	The phosphorylation-mimicking mutation AHA2S994D driven by its own promoter could largely compensate for the defective phenotypes of water loss, cytoplasmic alkalinization and ROS accumulation in both aha2-6 and bak1-4 mutants.	ros	176-179	H[+]-ATPase 2	Arabidopsis thaliana	201-207
35388002-6	2022	Consequently, immune cells lacking SPPL2b demonstrate increased anti-fungal ROS production, killing capacity and cytokine responses.	ros	76-79	signal peptide peptidase like 2B	Homo sapiens	35-41
35529295-2	2022	However, this phenomenon has never been reported in ROS proto-oncogene 1 (ROS1) fusion-positive lung adenocarcinoma.	ros	52-55	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	74-78
34995734-14	2022	Besides, protein-protein interaction (PPI) analysis demonstrated that a network consisted of FOXM1, CCNA2, CCNB1, MYBL2, PLK1 and CDK1 might be response for DATS-induced G2/M cell cycle arrest and increased intracellular ROS.	ros	221-224	forkhead box M1	Homo sapiens	93-98
34995734-14	2022	Besides, protein-protein interaction (PPI) analysis demonstrated that a network consisted of FOXM1, CCNA2, CCNB1, MYBL2, PLK1 and CDK1 might be response for DATS-induced G2/M cell cycle arrest and increased intracellular ROS.	ros	221-224	polo like kinase 1	Homo sapiens	121-125
35302183-0	2022	Effects of SIDT2 on the miR-25/NOX4/HuR axis and SIRT3 mRNA stability lead to ROS-mediated TNF-alpha expression in hydroquinone-treated leukemia cells.	ros	78-81	SID1 transmembrane family member 2	Homo sapiens	11-16
35093305-0	2022	ZEB1 induces ROS generation through directly promoting MCT4 transcription to facilitate breast cancer.	ros	13-16	zinc finger E-box binding homeobox 1	Homo sapiens	0-4
35093305-9	2022	In addition, the in vitro and in vivo experiments showed that ZEB1/MCT4 in synergy promoted the growth of breast cancer through ROS generation and autophagy, which can be reversed by a MCT4 inhibitor, 7ACC1.	ros	128-131	acetyl-CoA carboxylase alpha	Homo sapiens	202-206
35326405-9	2022	Finally, we observed that recombinant HLA-G also prevented LPS-induced ROS production by macrophages.	ros	71-74	major histocompatibility complex, class I, G	Homo sapiens	38-43
35246513-10	2022	The ability of DNMT1 to repress SIRT6 promoter partly was dependent on ROS-sensitive serine 154 phosphorylation.	ros	71-74	DNA methyltransferase 1	Homo sapiens	15-20
35068071-7	2022	Under acidic tumor microenvironment (TME) and 808 nm laser irradiation, BTZ is released and ROS is generated by Ce6 to destroy the "bounce-back" response pathway proteins, such as DDI2 and p97, which can effectively inhibit proteasomes and increase apoptosis.	ros	92-95	DNA damage inducible 1 homolog 2	Homo sapiens	180-184
35220212-7	2022	GGCT-ASOs also increased expression of cell-cycle regulating proteins, phospho-AMPK and ROS levels.	ros	88-91	gamma-glutamyl cyclotransferase	Mus musculus	0-4
35343092-8	2022	The ubiquitin-modified cyclin C then anchor at mitochondira, which induced mitochondrial fission and ROS synthesis.	ros	101-104	cyclin C	Homo sapiens	23-31
35343092-9	2022	Depleting CCNC or mutation on the ubiquitylation sites decreased mitochondrial ROS production and reduced cell apoptosis under cisplatin treatment.	ros	79-82	cyclin C	Homo sapiens	10-14
35090998-9	2022	Experimental results showed that LaCl3 decreased spatial learning and memory ability of offspring rats, decreased tethering protein complexes expression of MAM, damaged MAM structure, up-regulated NOX4 expression which led to active ROS-AMPK-mTOR signaling pathway.	ros	233-236	NADPH oxidase 4	Rattus norvegicus	197-201
35090998-9	2022	Experimental results showed that LaCl3 decreased spatial learning and memory ability of offspring rats, decreased tethering protein complexes expression of MAM, damaged MAM structure, up-regulated NOX4 expression which led to active ROS-AMPK-mTOR signaling pathway.	ros	233-236	mechanistic target of rapamycin kinase	Rattus norvegicus	242-246
35149217-7	2022	Whereas, the combined use of two ROS-specific inhibitors and adopted with melatonin markedly rescued PM2.5-triggered macrophage M1 polarization and foam cell formation by inhibiting NOX2-mediated crosstalk of Keap1/Nrf2/NF-kappaB and TLR4/TRAF6/NF-kappaB signaling pathways.	ros	33-36	kelch-like ECH-associated protein 1	Mus musculus	209-214
34999049-0	2022	Mechanistic insight into the synergism of IL-27 and IL-28B in regulation of benzo(a)pyrene-induced lung carcinogenesis associated ROS/NF-kappaB/NLRP3 crosstalk.	ros	130-133	interleukin 27	Mus musculus	42-47
34999049-11	2022	CONCLUSION: Altogether, the treatment in combination with IL-27 and IL-28B is an effective regimen to attenuate the ROS/NF-kappaB/NLRP3 axis associated with BaP-induced lung carcinogenesis.	ros	116-119	interleukin 27	Mus musculus	58-63
35042627-7	2022	The ROS scavenger NAC was used to study the role of ROS in cell senescence and in melanosome transfer.	ros	4-7	X-linked Kx blood group	Homo sapiens	18-21
35091545-4	2022	Our results showed that TFG-deficient THP-1 macrophages exhibit higher mitochondrial ROS production.	ros	85-88	trafficking from ER to golgi regulator	Homo sapiens	24-27
35061864-7	2022	These results thus provided multiple lines of biological evidence to support a model that BDAA interaction with NS4B may impair the integrity of YFV ROs, which not only inhibits viral RNA replication, but also promotes the release of viral RNA from ROs, which consequentially activates RIG-I and MDA5.	ros	149-152	DExD/H-box helicase 58	Homo sapiens	286-291
34718783-0	2022	miR169q and NUCLEAR FACTOR YA8 enhance salt tolerance by activating PEROXIDASE1 expression in response to ROS.	ros	106-109	peroxidase 1	Zea mays	68-79
34710487-6	2022	Decrease in PON2 augments Fis1 expression resulting in fragmentation of mitochondria and enhances the ROS production, decreases MMP, facilitates mPTP opening, and induces the release of Cyt-c, which activates the pro-apoptotic pathway.	ros	102-105	paraoxonase 2	Homo sapiens	12-16
35600154-9	2022	Overall, SPT exhibited a protective effect in RGC-5 cells exposed to a high-glucose environment via its antioxidant efficacy, inhibition of apoptosis and modulation of the ROS-dependent p38/JNK signaling cascade.	ros	172-175	mitogen-activated protein kinase 8	Mus musculus	190-193
35296207-2	2022	The purpose of this study was to investigate the role of NADPH oxidase (NOX) isoform NOX2-derived ROS in the regulation of ZIP2 expression, focusing on the role of the NOX2 cytosolic factor p67phox.	ros	98-101	solute carrier family 39 (zinc transporter), member 2	Mus musculus	123-127
35296207-7	2022	I/R-induced upregulation of STAT3 phosphorylation and ZIP2 expression was reversed by the ROS scavenger N-acetylcysteine (NAC) and the NOX inhibitor diphenyleneiodonium (DPI).	ros	90-93	solute carrier family 39 (zinc transporter), member 2	Mus musculus	54-58
35129048-12	2022	In addition, siRNA-mediated UCP2 knockdown further aggravated mitochondrial fragmentation and DeltaPsim depolarization and increased mitochondrial ROS production and cell apoptosis in HS-induced HUVECs, which were abolished by Drp1 inhibition.	ros	147-150	utrophin	Homo sapiens	227-231
35341501-9	2022	Nrf2 and Ass1 can play a certain role in eliminating ROS and ammonia detoxification by increasing their expression under the oxidative damage of rat liver cells caused by PFOA.	ros	53-56	argininosuccinate synthase 1	Rattus norvegicus	9-13
26142569-10	2015	A possible underlying mechanism is that the down-regulation of thioredoxin stimulated the up-regulation of ASK1, p-JNK, PTEN, and Txnip, as well as the down-regulation of p-AKT, ultimately increasing ROS levels and caspase3 activity.	ros	200-203	thioredoxin 1	Mus musculus	63-74
26142569-10	2015	A possible underlying mechanism is that the down-regulation of thioredoxin stimulated the up-regulation of ASK1, p-JNK, PTEN, and Txnip, as well as the down-regulation of p-AKT, ultimately increasing ROS levels and caspase3 activity.	ros	200-203	caspase 3	Mus musculus	215-223
26059056-13	2015	In conclusion, the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway is activated in lung cancer A549 cells, which could be modulated by curcumin to inhibit cell invasiveness.	ros	34-37	cytochrome b-245 beta chain	Homo sapiens	28-33
26059056-13	2015	In conclusion, the PKCalpha/Nox-2/ROS/ATF-2/MMP-9 signaling pathway is activated in lung cancer A549 cells, which could be modulated by curcumin to inhibit cell invasiveness.	ros	34-37	activating transcription factor 2	Homo sapiens	38-43
26009488-2	2015	Here we provide findings that Clnk may be is required for TNF induced cell death, it functions downstream of RIP3 and promotes TNF- induced ROS generation and MLKL tetramer formation and subsequent necrosis of L929 cells.	ros	140-143	cytokine-dependent hematopoietic cell linker	Mus musculus	30-34
26002466-5	2015	In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1alpha-induced expression of C/EBPbeta and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2).	ros	203-206	mitogen activated protein kinase kinase kinase 7	Rattus norvegicus	39-43
26002466-5	2015	In addition, we also demonstrated that TAK1/p38 mitogen-activated protein kinase (p38 MAPK) signaling exerted negative effect on IL-1alpha-induced expression of C/EBPbeta and SDF-1 through counteracting ROS-dependent up-regulation of nuclear factor erythroid 2-related factor 2 (NRF2).	ros	203-206	CCAAT/enhancer binding protein beta	Rattus norvegicus	161-170
26112249-7	2015	Finally, the pretreatment of antioxidant NAC ameliorated Fas, FADD and caspase 8/3 expressions, which illustrated that TCBQ-induced apoptotic signaling is ROS dependent.	ros	155-158	caspase 8	Rattus norvegicus	71-80
25950987-12	2015	N-Acetyl-l-cysteine (NAC) scavenged ROS formation and consequently alleviated PCB29-pQ-induced expression of ER stress-related genes.	ros	36-39	X-linked Kx blood group	Homo sapiens	21-24
26066050-9	2015	Finally, the ROS scavenger NAC prevented the hyperoxia-induced increase in Hsp70 expression and reduced the interaction of Hsp70 with AIF in hyperoxic PAECs.	ros	13-16	X-linked Kx blood group	Homo sapiens	27-30
26066050-9	2015	Finally, the ROS scavenger NAC prevented the hyperoxia-induced increase in Hsp70 expression and reduced the interaction of Hsp70 with AIF in hyperoxic PAECs.	ros	13-16	heat shock protein family A (Hsp70) member 4	Homo sapiens	75-80
26066050-9	2015	Finally, the ROS scavenger NAC prevented the hyperoxia-induced increase in Hsp70 expression and reduced the interaction of Hsp70 with AIF in hyperoxic PAECs.	ros	13-16	heat shock protein family A (Hsp70) member 4	Homo sapiens	123-128
26066050-9	2015	Finally, the ROS scavenger NAC prevented the hyperoxia-induced increase in Hsp70 expression and reduced the interaction of Hsp70 with AIF in hyperoxic PAECs.	ros	13-16	apoptosis inducing factor mitochondria associated 1	Homo sapiens	134-137
26066050-12	2015	The hyperoxia-induced increase in Hsp70 expression and Hsp70/AIF interaction is contributed to ROS formation.	ros	95-98	heat shock protein family A (Hsp70) member 4	Homo sapiens	34-39
26066050-12	2015	The hyperoxia-induced increase in Hsp70 expression and Hsp70/AIF interaction is contributed to ROS formation.	ros	95-98	heat shock protein family A (Hsp70) member 4	Homo sapiens	55-60
26066050-12	2015	The hyperoxia-induced increase in Hsp70 expression and Hsp70/AIF interaction is contributed to ROS formation.	ros	95-98	apoptosis inducing factor mitochondria associated 1	Homo sapiens	61-64
25463045-8	2015	STC2 knockdown also attenuated the H202-induced oxidative stress on H460 cell viability with a subsequent increase in intracellular ROS levels, which suggest a protective role of STC2 in redox regulatory system of lung cancer.	ros	132-135	stanniocalcin 2	Homo sapiens	0-4
25463045-8	2015	STC2 knockdown also attenuated the H202-induced oxidative stress on H460 cell viability with a subsequent increase in intracellular ROS levels, which suggest a protective role of STC2 in redox regulatory system of lung cancer.	ros	132-135	stanniocalcin 2	Homo sapiens	179-183
25825937-10	2015	The Gsdma3 Y344H mutant protein and N-terminal domain-induced autophagy was associated with mitochondria and ROS generation.	ros	109-112	gasdermin A3	Mus musculus	4-10
25968268-5	2015	Also, radical oxygen species (ROS) production followed by nuclear factor kappa B (NF-kappaB) activation was involved in the above synergistic cytotoxicity, which was confirmed by the repression of the actions by an ROS inhibitor (NAC).	ros	30-33	X-linked Kx blood group	Homo sapiens	230-233
25968268-5	2015	Also, radical oxygen species (ROS) production followed by nuclear factor kappa B (NF-kappaB) activation was involved in the above synergistic cytotoxicity, which was confirmed by the repression of the actions by an ROS inhibitor (NAC).	ros	215-218	X-linked Kx blood group	Homo sapiens	230-233
25758431-8	2015	In vitro, either pharmacological inhibition of EGFR/AKT or sh-RNA silencing of EGFR significantly inhibited high concentration glucose (HG)-induced ROS generation and subsequently cell apoptosis in both cardiac H9C2 cells and primary rat cardiomyocytes, respectively.	ros	148-151	epidermal growth factor receptor	Rattus norvegicus	47-51
25758431-8	2015	In vitro, either pharmacological inhibition of EGFR/AKT or sh-RNA silencing of EGFR significantly inhibited high concentration glucose (HG)-induced ROS generation and subsequently cell apoptosis in both cardiac H9C2 cells and primary rat cardiomyocytes, respectively.	ros	148-151	epidermal growth factor receptor	Rattus norvegicus	79-83
25758431-9	2015	The ROS reduction by EGFR inhibitor was associated with the decreased NADPH oxidase activity and expression in H9c2 cells.	ros	4-7	epidermal growth factor receptor	Rattus norvegicus	21-25
25758431-11	2015	This study provides evidence that EGFR has a key role in the pathogenesis of STZ-induced diabetic cardiac damage and remodeling via ROS generation, and suggests that EGFR may be a potential target in treating diabetic cardiomyopathy.	ros	132-135	epidermal growth factor receptor	Rattus norvegicus	34-38
26137628-9	2015	Intracellular ROS levels and the gene expression of JAK2 and STAT3 in PM2.5 + NAC protection group were lower than the respective PM2.5 exposure group, the differences were statistically significant (P &lt; 0.05).	ros	14-17	X-linked Kx blood group	Homo sapiens	78-81
25399916-5	2015	Excessive amounts of ROS production and changes in mitochondrial membrane potential were prevented by Drp1 inhibition under Ang II and H2 O2 .	ros	21-24	dynamin 1-like	Rattus norvegicus	102-106
25798846-5	2015	Additionally, elevated mitochondrial ROS level, colocalization of NLRP3/ASC/mitochondria in peripheral blood mononuclear cells from CKD-HD patients and down-regulation of CASP-1, IL1-beta and IL-18 protein levels in immune-cells of CKD-HD patients stimulated with LPS/ATP in presence of mitoTEMPO, inhibitor of mitochondrial ROS production, suggested a possible role of this organelle in the aforementioned CKD-associated inflammasome activation.	ros	325-328	interleukin 18	Homo sapiens	192-197
25672415-2	2015	We recently reported that ROS-mediated oxidative stress promotes phosphorylation of endogenous SHP-2 in astrocytes and complex formation between caveolin-1 and SHP-2 in response to oxidative stress.	ros	26-29	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	95-100
25672415-2	2015	We recently reported that ROS-mediated oxidative stress promotes phosphorylation of endogenous SHP-2 in astrocytes and complex formation between caveolin-1 and SHP-2 in response to oxidative stress.	ros	26-29	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	160-165
25672415-5	2015	Moreover, deletion of the N-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes.	ros	314-317	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	42-47
25672415-5	2015	Moreover, deletion of the N-SH2 domain of SHP-2 affected H2O2-mediated ERK phosphorylation and Src phosphorylation at Tyr 419 in primary astrocytes, suggesting that N-SH2 domain of SHP-2 is responsible for the binding of caveolin-1 and contributes to the regulation of Src phosphorylation and activation following ROS-induced oxidative stress in brain astrocytes.	ros	314-317	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	181-186
25377088-12	2015	These increased ROS levels could be normalized with specific mitochondrial ROS scavengers (MitoTEMPO, mnSOD).	ros	16-19	superoxide dismutase 2	Rattus norvegicus	102-107
25377088-12	2015	These increased ROS levels could be normalized with specific mitochondrial ROS scavengers (MitoTEMPO, mnSOD).	ros	75-78	superoxide dismutase 2	Rattus norvegicus	102-107
26510432-1	2015	Nox generated ROS, particularly those derived from Nox1, Nox2 and Nox4, have emerged as important regulators of the actin cytoskeleton and cytoskeleton-supported cell functions, such as migration and adhesion.	ros	14-17	cytochrome b-245 beta chain	Homo sapiens	57-61
25460651-2	2015	Although previous studies suggest possible role of oxidative stress, the precise mechanisms of PCB-induced ROS production in liver still remain to be fully assessed.	ros	107-110	pyruvate carboxylase	Rattus norvegicus	95-98
25445985-0	2015	Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism.	ros	96-99	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	45-50
25534001-6	2014	Additionally, we observed that plasma induces ROS, which activated MAPK p38 and inhibits p42/p44 MAPK, leading to cancer cell death.	ros	46-49	erythrocyte membrane protein band 4.2	Homo sapiens	89-92
25468822-9	2014	Furthermore, G226 (0.125-2 mumol/L) dose-dependently elevated the intracellular levels of H2O2 and in the cancer cells, and pretreatment with GSH, NAC or DTT not only blocked G226-induced intracellular accumulation of ROS, but also abrogated G226-mediated phosphorylation of H2AX, apoptosis and cytotoxicity.	ros	218-221	X-linked Kx blood group	Homo sapiens	147-150
25429618-5	2014	Time-lapse imaging revealed that TRPM2 deficiency had no effect on the ischemia-induced increase in the [Zn(2+)]c but abolished the cytosolic Zn(2+) accumulation during reperfusion as well as ROS-elicited increases in the [Zn(2+)]c. These results provide the first evidence to show a critical role for TRPM2 channel activation during reperfusion in the delayed increase in the [Zn(2+)]c and CA1 pyramidal neuronal death and identify TRPM2 as a key molecule signaling ROS generation to postischemic brain injury.	ros	192-195	transient receptor potential cation channel subfamily M member 2	Homo sapiens	33-38
25429618-5	2014	Time-lapse imaging revealed that TRPM2 deficiency had no effect on the ischemia-induced increase in the [Zn(2+)]c but abolished the cytosolic Zn(2+) accumulation during reperfusion as well as ROS-elicited increases in the [Zn(2+)]c. These results provide the first evidence to show a critical role for TRPM2 channel activation during reperfusion in the delayed increase in the [Zn(2+)]c and CA1 pyramidal neuronal death and identify TRPM2 as a key molecule signaling ROS generation to postischemic brain injury.	ros	467-470	transient receptor potential cation channel subfamily M member 2	Homo sapiens	33-38
25152235-1	2014	15(S)-Hydroxyeicosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1/2 (15-LO1/2) metabolite of arachidonic acid (AA), induces CD36 expression through xanthine oxidase and NADPH oxidase-dependent ROS production and Syk and Pyk2-dependent STAT1 activation.	ros	204-207	xanthine dehydrogenase	Mus musculus	159-175
25152235-1	2014	15(S)-Hydroxyeicosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1/2 (15-LO1/2) metabolite of arachidonic acid (AA), induces CD36 expression through xanthine oxidase and NADPH oxidase-dependent ROS production and Syk and Pyk2-dependent STAT1 activation.	ros	204-207	spleen tyrosine kinase	Mus musculus	223-226
25152235-1	2014	15(S)-Hydroxyeicosatetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1/2 (15-LO1/2) metabolite of arachidonic acid (AA), induces CD36 expression through xanthine oxidase and NADPH oxidase-dependent ROS production and Syk and Pyk2-dependent STAT1 activation.	ros	204-207	signal transducer and activator of transcription 1	Homo sapiens	246-251
25064608-6	2014	Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK.	ros	141-144	2,4-dienoyl-CoA reductase 1	Homo sapiens	89-94
25064608-6	2014	Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK.	ros	141-144	2,4-dienoyl-CoA reductase 1	Homo sapiens	89-94
25064608-6	2014	Moreover, antioxidant, NADPH oxidase inhibitor and specific knock-out for p47 subunit of NADPH oxidase could effectively block NADPH oxidase-ROS-dependent JNK activation, suggesting that NADPH oxidase is an upstream regulator of JNK MAPK.	ros	141-144	2,4-dienoyl-CoA reductase 1	Homo sapiens	89-94
25064608-7	2014	Conversely, a specific JNK inhibitor could inhibit ASC-induced NADPH oxidase activation and down-regulate ROS levels as well, indicating that JNK might also regulate NADPH oxidase activity to some extent.	ros	106-109	2,4-dienoyl-CoA reductase 1	Homo sapiens	166-171
25064608-10	2014	Taken together, we provide a proof for inducing hepatoma carcinoma cell apoptosis by activating the JNK-NADPH oxidase-ROS-dependent self-driven signal circuit pathway.	ros	118-121	2,4-dienoyl-CoA reductase 1	Homo sapiens	104-109
35101253-0	2022	beta-Elemene induces apoptosis and autophagy in colorectal cancer cells through regulating the ROS/AMPK/mTOR pathway.	ros	95-98	mechanistic target of rapamycin kinase	Mus musculus	104-108
35101253-8	2022	These effects were associated with regulation of the ROS/AMPK/mTOR signaling.	ros	53-56	mechanistic target of rapamycin kinase	Mus musculus	62-66
24902638-11	2014	Taken together, these results show a new function of BRCA2 protein as modulator of anoikis sensitivity through an evolutionarily-conserved molecular mechanism involving regulation of ROS production and/or detoxification by BRCA2 during PCD processes.	ros	183-186	BRCA2 DNA repair associated	Homo sapiens	53-58
24902638-11	2014	Taken together, these results show a new function of BRCA2 protein as modulator of anoikis sensitivity through an evolutionarily-conserved molecular mechanism involving regulation of ROS production and/or detoxification by BRCA2 during PCD processes.	ros	183-186	BRCA2 DNA repair associated	Homo sapiens	223-228
2836739-6	1988	Using the insulin receptor-related avian sarcoma oncogene v-ros as a probe, we have isolated and characterized the complementary DNA of a novel gene, ltk (leukocyte tyrosine kinase).	ros	60-63	leukocyte tyrosine kinase	Mus musculus	150-153
24909818-7	2014	Exposure to 10(-5)M BPA resulted in greater oxidative stress and then inhibited cell proliferation, while ROS scavenger NAC effectively blocked these effects.	ros	106-109	NLR family, pyrin domain containing 1A	Mus musculus	120-123
25078150-24	2014	Toxic effect of free Hb-alpha, in colonic epithelial cells, is therefore through production of ROS formation modulated by impairment of antioxidant effects.	ros	95-98	sodium voltage-gated channel alpha subunit 2	Homo sapiens	21-29
25088999-9	2014	Finally, PHD3(-/-) cells were resistant to cell death in prolonged hypoxia with decreased production of ROS.	ros	104-107	egl-9 family hypoxia inducible factor 3	Homo sapiens	9-13
24867259-0	2014	Nutlin-3 induces BCL2A1 expression by activating ELK1 through the mitochondrial p53-ROS-ERK1/2 pathway.	ros	84-87	ETS transcription factor ELK1	Homo sapiens	49-53
25076856-7	2014	We also observed that Lcn2 down-regulated the proapoptotic protein Bax, decreased the levels of cellular ROS, and up-regulated the expression of superoxide dismutases (SOD1 and SOD2).	ros	105-108	lipocalin 2	Homo sapiens	22-26
25010005-8	2014	Finally increased activity of antioxidation pathways was observed in BRCA1-transfected cells, that could be a consequence of ROS production by activated oxidative phosphorylation.	ros	125-128	BRCA1 DNA repair associated	Homo sapiens	69-74
24785190-9	2014	In general, LMX1B may be considered to be a negative regulator of the fibrosis index, transforming growth factor-betal, collagen type III, fibronectin, cleaved caspase-3, cell apoptosis, ROS, and malondialdehyde (r = -0.756, -0.698, -0.921, -0.923, -0.843, -0.794, -0.883, and -0.825, all P &lt; 0.01).	ros	187-190	LIM homeobox transcription factor 1 beta	Rattus norvegicus	12-17
24699798-0	2014	Non-esterified fatty acids activate the ROS-p38-p53/Nrf2 signaling pathway to induce bovine hepatocyte apoptosis in vitro.	ros	40-43	mitogen-activated protein kinase 14	Bos taurus	44-47
24699798-9	2014	These results indicate that NEFAs activate the ROS-p38-p53/Nrf2 signaling pathway to induce apoptotic damage in bovine hepatocytes.	ros	47-50	mitogen-activated protein kinase 14	Bos taurus	51-54
24713652-6	2014	The capillary rarefaction in BAT that was brought about by obesity or Vegfa ablation diminished beta-adrenergic signaling, increased mitochondrial ROS production, and promoted mitophagy.	ros	147-150	vascular endothelial growth factor A	Mus musculus	70-75
24751806-1	2014	The mitochondrial kinase PINK1 and the ubiquitin ligase Parkin are participating in quality control after CCCP- or ROS-induced mitochondrial damage, and their dysfunction is associated with the development and progression of Parkinson"s disease.	ros	115-118	PTEN induced kinase 1	Homo sapiens	25-30
24667392-1	2014	We previously reported that F4/80(+) Kupffer cells are subclassified into CD68(+) Kupffer cells with phagocytic and ROS producing capacity, and CD11b(+) Kupffer cells with cytokine-producing capacity.	ros	116-119	adhesion G protein-coupled receptor E1	Mus musculus	28-33
24388604-12	2014	Western blotting revealed that DPI and NAC attenuated the effect of TMF, suggesting that TMF induces ROS through the NOX2 pathway and regulates keratinocyte migration.	ros	101-104	X-linked Kx blood group	Homo sapiens	39-42
24388604-12	2014	Western blotting revealed that DPI and NAC attenuated the effect of TMF, suggesting that TMF induces ROS through the NOX2 pathway and regulates keratinocyte migration.	ros	101-104	cytochrome b-245 beta chain	Homo sapiens	117-121
24625085-15	2014	CONCLUSIONS: The gold (I) N-heterocyclic carbene complex (C22H26N6AuO2PF6) designated as complex 3 induced ROS and p53 dependent apoptosis in B16F10 cells involving the mitochondrial death pathway along with suppression of melanoma tumor growth by regulating the levels of pro and anti apoptotic factors (p53, p21, NF-kappaB, VEGF and MMP-9).	ros	107-110	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	310-313
24625085-15	2014	CONCLUSIONS: The gold (I) N-heterocyclic carbene complex (C22H26N6AuO2PF6) designated as complex 3 induced ROS and p53 dependent apoptosis in B16F10 cells involving the mitochondrial death pathway along with suppression of melanoma tumor growth by regulating the levels of pro and anti apoptotic factors (p53, p21, NF-kappaB, VEGF and MMP-9).	ros	107-110	vascular endothelial growth factor A	Mus musculus	326-330
24134701-5	2014	ROS-mediated autophagy was downregulated in the liver of melatonin-treated animals and was accompanied by significant accumulation of p62.	ros	0-3	nucleoporin 62	Mus musculus	134-137
24475205-2	2014	The p66Shc stress adaptor protein controls oxidative stress response of somatic cells by regulating intracellular ROS levels through multiple pathways, including mitochondrial ROS generation and the repression of antioxidant gene expression.	ros	114-117	SHC adaptor protein 1	Bos taurus	4-10
24475205-2	2014	The p66Shc stress adaptor protein controls oxidative stress response of somatic cells by regulating intracellular ROS levels through multiple pathways, including mitochondrial ROS generation and the repression of antioxidant gene expression.	ros	176-179	SHC adaptor protein 1	Bos taurus	4-10
24475205-5	2014	Using RNA interference in bovine zygotes we show that p66Shc knockdown embryos exhibited increased MnSOD levels, reduced intracellular ROS and DNA damage that resulted in a greater propensity for development to the blastocyst stage.	ros	135-138	SHC adaptor protein 1	Bos taurus	54-60
24475205-6	2014	P66Shc knockdown embryos were stress resistant exhibiting significantly reduced intracellular ROS levels, DNA damage, permanent 2-4 cell embryo arrest and diminished apoptosis frequencies after oxidant treatment.	ros	94-97	SHC adaptor protein 1	Bos taurus	0-6
24664744-1	2014	Light-activated movement of transducin-alpha (Galphat1) from rod photoreceptor outer segments (ROS) into inner segments (IS) enables rods to rapidly adapt to changes in light intensity.	ros	95-98	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	28-38
24664744-3	2014	Loss- of- expression of the retina specific cell surface protein, retinoschsin (Rs1-KO), led to a dramatic 3-10 fold increase, depending on age, in the luminance threshold for transducin translocation from ROS into IS compared with wild-type control.	ros	206-209	guanine nucleotide binding protein, alpha transducing 1	Mus musculus	176-186
24895546-0	2014	Alteration of ROS homeostasis and decreased lifespan in S. cerevisiae elicited by deletion of the mitochondrial translocator FLX1.	ros	14-17	flavin adenine dinucleotide transporter FLX1	Saccharomyces cerevisiae S288C	125-129
24895546-1	2014	This paper deals with the control exerted by the mitochondrial translocator FLX1, which catalyzes the movement of the redox cofactor FAD across the mitochondrial membrane, on the efficiency of ATP production, ROS homeostasis, and lifespan of S. cerevisiae.	ros	209-212	flavin adenine dinucleotide transporter FLX1	Saccharomyces cerevisiae S288C	76-80
24895546-2	2014	The deletion of the FLX1 gene resulted in respiration-deficient and small-colony phenotype accompanied by a significant ATP shortage and ROS unbalance in glycerol-grown cells.	ros	137-140	flavin adenine dinucleotide transporter FLX1	Saccharomyces cerevisiae S288C	20-24
25219661-11	2014	Our results indicate that cilostazol protected endothelial cells against ethanol-induced endothelial dysfunction by inhibiting ROS-mediated activation of MMP-9.	ros	127-130	matrix metallopeptidase 9	Homo sapiens	154-159
24105651-6	2014	Importantly, the in vivo inhibition of JNK signaling with SP600125 protected C57BL/6 CD4(+) CD8(+) thymocytes from depletion via multiple mechanisms as follows: lower intracellular ROS, inflammatory cytokines, Bax and caspase 3 activity, increase in Bcl-xL amounts, and prevention of the loss in mitochondrial membrane potential.	ros	181-184	mitogen-activated protein kinase 8	Mus musculus	39-42
24105651-6	2014	Importantly, the in vivo inhibition of JNK signaling with SP600125 protected C57BL/6 CD4(+) CD8(+) thymocytes from depletion via multiple mechanisms as follows: lower intracellular ROS, inflammatory cytokines, Bax and caspase 3 activity, increase in Bcl-xL amounts, and prevention of the loss in mitochondrial membrane potential.	ros	181-184	CD4 antigen	Mus musculus	85-88
25095669-6	2014	Probably an increase of the level of cytochrome P450 2E1 leads to induction of expression of enzymes with cytoprotective properties, such as heme oxygenase-1, by ROS-dependent activation of certain signaling pathways.	ros	162-165	heme oxygenase 1	Rattus norvegicus	141-157
25028602-5	2014	Our results clearly show that NAC administration depresses the expression of manganese superoxide dismutase (MnSOD) and TP53-induced glycolysis and apoptosis regulator (TIGAR), both of which play a predominant antioxidant role in mitochondria by reducing ROS level.	ros	255-258	NLR family, pyrin domain containing 1A	Mus musculus	30-33
25482750-0	2014	New cross talk between ROS, ABA and auxin controlling seed maturation and germination unraveled in APX6 deficient Arabidopsis seeds.	ros	23-26	ascorbate peroxidase 6	Arabidopsis thaliana	99-103
25482750-3	2014	APX6 replaces APX1 as the dominant APX in dry seeds, and its loss-of-function results in reduced germination due to over accumulation of ROS and oxidative damage.	ros	137-140	ascorbate peroxidase 6	Arabidopsis thaliana	0-4
25482750-7	2014	Here we provide additional evidence linking ABI4 with ABA- and auxin-controlled inhibition of germination and suggest a hypothetical model for the role of APX6 in the regulation of the crosstalk between these hormones and ROS.	ros	222-225	ascorbate peroxidase 6	Arabidopsis thaliana	155-159
25462070-4	2014	The E2/ER-mediated SOD2 up-regulation results in minimized ROS generation, which highly favors healthy cardiovascular function.	ros	59-62	cystatin 12, pseudogene	Homo sapiens	4-9
24386346-6	2013	Reactive oxygen specisis (ROS)-dependent p38 and c-Jun NH(2)-terminal kinases (JNK) MAPK activation was required for CoCl2-induced RPE cell death, and Rg-1 pre-treatment significantly inhibited ROS production and following p38/JNK activation.	ros	26-29	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	49-54
24048885-10	2013	Taken together, we showed that AEA induces a reduction in decidual cell viability by a mechanism involving CB1 activation, which results in ceramide synthesis de novo and p38 phosphorylation, followed by mitochondrial stress and ROS production, leading to apoptosis.	ros	229-232	cannabinoid receptor 1	Rattus norvegicus	107-110
24144778-8	2013	Over-expression of Prp4K resulted in a significant decrease in ROS production possibly through activation of an anti-oxidant enzyme system.	ros	63-66	pre-mRNA processing factor 4B	Homo sapiens	19-24
24144778-9	2013	To elucidate an integrated mechanism, Prp4K knockdown by siRNA ultimately restored radiation-induced ROS generation.	ros	101-104	pre-mRNA processing factor 4B	Homo sapiens	38-43
23876460-8	2013	Collectively, these results suggest that Cd increases intracellular Ca2+ or ROS, which induces gamma-secretase-dependent N-cad/CTF2 production via the activation of the ERK signaling pathway in C6 glial cells.	ros	76-79	cadherin 2	Homo sapiens	121-126
24131900-9	2013	Niacin deficiency-induced photosensitivity was mediated through EP4 signaling in response to increased PGE2 production via induction of ROS formation.	ros	136-139	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	64-67
24136222-0	2013	Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.	ros	50-53	DM1 protein kinase	Homo sapiens	0-33
24136222-0	2013	Myotonic dystrophy protein kinase (DMPK) prevents ROS-induced cell death by assembling a hexokinase II-Src complex on the mitochondrial surface.	ros	50-53	DM1 protein kinase	Homo sapiens	35-39
24113182-12	2013	Thus, TAK1 deficiency in metastatic cancer cells increases integrin:Rac-induced ROS, which negatively regulated Rho by LMW-PTP to accelerate EMT.	ros	80-83	acid phosphatase 1	Homo sapiens	119-126
24116071-3	2013	Our in silico prediction of the hXRCC3 structure suggests that 6 out of 8 cysteines are potentially accessible to the solvent and therefore potentially exposed to ROS attack.	ros	163-166	X-ray repair cross complementing 3	Homo sapiens	32-38
24116071-11	2013	Collectively, our results demonstrate that the DNA repair protein hXRCC3 is a target of ROS induced by environmental factors and raise the possibility that the redox environment might participate in regulating the HR pathway.	ros	88-91	X-ray repair cross complementing 3	Homo sapiens	66-72
23911867-9	2013	On the other hand, inhibition of ROS not only attenuated high-glucose-mediated T-cell expression of CXCR4 and HIF-1alpha but also mitigated T-cell HIV entry in a high-glucose milieu.	ros	33-36	C-X-C motif chemokine receptor 4	Homo sapiens	100-105
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	157-160	superoxide dismutase 2	Rattus norvegicus	97-119
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	157-160	superoxide dismutase 2	Rattus norvegicus	121-125
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	303-306	superoxide dismutase 2	Rattus norvegicus	97-119
24058615-6	2013	An unexpected age-related decrease in the mitochondrial proteins peroxiredoxin III (Prx III) and superoxide dismutase 2 (SOD2), usually induced by increased ROS and involved in mitochondrial biogenesis, suggested a prevailing relevance of the age-reduced mitochondrial biogenesis above the induction by ROS in the regulation of expression of these genes with aging.	ros	303-306	superoxide dismutase 2	Rattus norvegicus	121-125
24494190-7	2014	Furthermore, cells expressing mitochondria targeted HO-1 also induced higher ROS production.	ros	77-80	heme oxygenase 1	Rattus norvegicus	52-56
23576581-7	2013	These results suggest that cAMP via PKA pathway attenuates the overexpression of Gi proteins and hyperproliferation of VSMC from SHR through the inhibition of ROS and ROS-mediated transactivation of EGF-R/PDGF-R and MAPK signaling pathways.	ros	167-170	epidermal growth factor receptor	Rattus norvegicus	199-204
23541442-4	2013	IL-18 induced Nox1-dependent ROS generation, TRAF3IP2 expression, and IKK/NF-kappaB and JNK/AP-1 activation.	ros	29-32	interleukin 18	Homo sapiens	0-5
22553146-4	2013	Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury.	ros	75-78	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	135-140
22553146-4	2013	Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury.	ros	75-78	kinase insert domain receptor	Homo sapiens	173-188
22553146-4	2013	Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury.	ros	75-78	kinase insert domain receptor	Homo sapiens	190-197
22553146-4	2013	Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury.	ros	75-78	kinase insert domain receptor	Homo sapiens	199-202
22553146-4	2013	Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury.	ros	75-78	kinase insert domain receptor	Homo sapiens	203-208
22553146-13	2013	We conclude that a pathway of tyrosine phosphatase SHP-1-regulated VEGFR-2 dephosphorylation through NADPH oxidase-derived ROS is involved in the CML-triggered endothelial cell dysfunction/injury.	ros	123-126	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	51-56
22553146-13	2013	We conclude that a pathway of tyrosine phosphatase SHP-1-regulated VEGFR-2 dephosphorylation through NADPH oxidase-derived ROS is involved in the CML-triggered endothelial cell dysfunction/injury.	ros	123-126	kinase insert domain receptor	Homo sapiens	67-74
23524239-4	2013	We observed an increased expression of PDH and a decreased expression of ACL, PEPCK, and acetyl-GD3 in BD lymphoblast cells compared to normal cells, possibly resulting in the high ROS levels, mitochondrial membrane depolarization, and apoptosis typically found in BD.	ros	181-184	ATP citrate lyase	Homo sapiens	73-76
23667638-8	2013	The blockage of ROS by DMTU and NAC prevented the apoptosis of BMSCs induced by homocysteine, indicating ROS was involved in the apoptosis of BMSCs.	ros	16-19	X-linked Kx blood group	Homo sapiens	32-35
23494980-8	2013	The enhanced mitochondrial ROS generation was associated with a late induction of sperm membrane lipid peroxidation, as assessed by BODIPY C11 , when evaluated at 6 h, but not at 1 h, after washing from SP.	ros	27-30	RNA polymerase III subunit K	Homo sapiens	139-142
23261939-5	2013	The H2O2-induced cell death, ROS production, and caspase-3 activation in SH-SY5Y cells were enhanced by the transfection of the PINK1 P209A mutant.	ros	29-32	PTEN induced kinase 1	Homo sapiens	128-133
23353834-5	2013	The results show that HG increases TXNIP expression in TR-rPCT1, which correlates positively with ROS generation, protein S-nitrosylation, and pro-apoptotic caspase-3 activation.	ros	98-101	thioredoxin interacting protein	Rattus norvegicus	35-40
23313662-7	2013	In case of spleen, ROS generation and mitochondrial trans-membrane potential changes promotes intrinsic pathway of apoptosis that was p53 independent, ultimately leads to decrease in CD4(+) T cell population and increase in CD8(+) T cell population.	ros	19-22	CD4 antigen	Mus musculus	183-186
23593194-7	2013	In vitro study using purified CD14++ monocytes revealed that elevation in extracellular [Na(+)] could lead to CD14++CD16+ expansion via a ROS dependent manner.	ros	138-141	Fc gamma receptor IIIa	Homo sapiens	116-120
23318226-10	2013	These results suggested that ATPgammaS-induced cPLA2/COX-2 expression and PGE2 secretion is mediated through a PKC/NADPH oxidase/ROS/STAT3-dependent pathway in VSMCs.	ros	129-132	phospholipase A2 group IVA	Homo sapiens	47-52
23333832-9	2013	Although all drugs attenuated mitochondrial dysfunction caused by iron overload, only an MCU blocker could completely prevent ROS production and mitochondrial depolarization.	ros	126-129	mitochondrial calcium uniporter	Rattus norvegicus	89-92
23220614-8	2013	Furthermore, the ROS inhibitor (NAC) notably promoted the inhibited effect of ISO on the ERK1/2 kinase.	ros	17-20	X-linked Kx blood group	Homo sapiens	32-35
23054367-7	2013	Conversely, ethanol-induced ROS generation was inhibited if VDR was activated or Ang II was blocked by an angiotensin II type 1 (AT1) receptor blocker (Losartan).	ros	28-31	vitamin D receptor	Homo sapiens	60-63
23054367-10	2013	These findings indicated that ethanol-induced T cell apoptosis was mediated through ROS generation in response to ethanol-induced down regulation of VDR and associated activation of the RAS.	ros	84-87	vitamin D receptor	Homo sapiens	149-152
23267072-10	2013	Inhibition of p66(Shc) expression and mitochondrial translocation by aPC normalized mitochondrial ROS production and the mitochondrial membrane potential in glucose-treated podocytes.	ros	98-101	SHC adaptor protein 1	Homo sapiens	18-21
23843863-15	2013	The findings of this study demonstrate that S-[6]-gingerol protects HuH7 cells against IL1beta-induced inflammatory insults through inhibition of the ROS/NF kappa B/COX2 pathway.	ros	150-153	MIR7-3 host gene	Homo sapiens	68-72
23038752-7	2013	ROS activation of FoxO and NF-kappaB and their downstream targets, atrogin-1 and MuRF1, was observed in M-ERRgamma(-/-) myocytes.	ros	0-3	tripartite motif-containing 63	Mus musculus	81-86
23241962-3	2013	We describe a novel intestinal epithelial FPR signaling pathway that is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1.	ros	192-195	annexin A1	Homo sapiens	111-121
23241962-3	2013	We describe a novel intestinal epithelial FPR signaling pathway that is activated by an endogenous FPR ligand, annexin A1 (ANXA1), and its cleavage product Ac2-26, which mediate activation of ROS by an epithelial NADPH oxidase, NOX1.	ros	192-195	annexin A1	Homo sapiens	123-128
22772750-6	2013	Sequencing and similarity analysis revealed that TDFs present homologies chiefly with proteins involved in chaperone activity and protein degradation (hsps, proteinase precursor), in protein synthesis (elongation factor, ribosomal proteins) and in the ROS scavenging pathway (phenylalanine ammonia-lyase, peroxidase).	ros	252-255	peroxidase N1	Solanum tuberosum	305-315
23516464-4	2013	Human PRR over-expression alone increased ROS levels, NADPH oxidase activity, as well as NADPH oxidase (NOX) isoforms 2 and 4 mRNA expression levels and these effects were not blocked by losartan.	ros	42-45	ATPase H+ transporting accessory protein 2	Homo sapiens	6-9
23516464-7	2013	In conclusion, human PRR over-expression induced ROS production through both angiotensin II-dependent and -independent mechanisms.	ros	49-52	ATPase H+ transporting accessory protein 2	Homo sapiens	21-24
23516464-8	2013	We showed that PRR-mediated angiotensin II-independent ROS formation is associated with activation of the MAPK/ERK1/2 and PI3/Akt signaling pathways and up-regulation of mRNA level of NOX 2 and NOX4 isoforms in neuronal cells.	ros	55-58	ATPase H+ transporting accessory protein 2	Homo sapiens	15-18
23359639-8	2013	GLP-1 concentration-dependently improved cell viability in wild-type cardiomyocyte against ROS stress, and the ceiling response concentration (200 nM) was chosen for studies.	ros	91-94	glucagon	Rattus norvegicus	0-5
23187810-6	2012	NCF2 knockdown by siRNA results in a significant reduction of ROS production and stimulates cell death, suggesting a protective function of Nox2-generated ROS in cells against apoptosis.	ros	155-158	cytochrome b-245 beta chain	Homo sapiens	140-144
22891289-6	2012	Suppression of iTreg differentiation from naive CD4(+) cells by gr-MDSC occurs early in the polarization process, requires inhibition of early T cell activation, and depends on ROS and IDO but does not require arginase 1, iNOS, NO, cystine/cysteine depletion, PD-1 and PD-L1 signaling, or COX-2.	ros	177-180	CD4 antigen	Mus musculus	48-51
22722016-7	2012	MeHg-induced ROS production appears to inhibit the activity of the glutamine synthetase (GS), leading to Glu metabolism dysfunction.	ros	13-16	glutamate-ammonia ligase	Rattus norvegicus	67-87
22842544-6	2012	Pretreatment with N-acetyl-l-cysteine (NAC) partly recovered the expression levels of c-FLIPL and c-FLIPs proteins were downregulated by the AMA treatment, suggesting that AMA appears to be partially dependent on the generation of ROS for downregulation of c-FLIPL and c-FLIPs.	ros	231-234	X-linked Kx blood group	Homo sapiens	39-42
22252379-6	2012	PE-induced Bcl-2 protein increase, Bax mitochondrial decrease and inhibition of cytochrome C release and Caspase 3 activation, as well as ROS production were blunted by GAPDH activity inhibition.	ros	138-141	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	169-174
22931549-9	2012	PM also mediated intracellular calcium mobilization via the transient receptor potential cation channel M2 (TRPM2), in a ROS-dependent manner with subsequent activation of the Ca2+-dependent protease calpain.	ros	121-124	transient receptor potential cation channel subfamily M member 2	Homo sapiens	108-113
22931549-12	2012	CONCLUSIONS: These results demonstrate that PM induces marked increases in vascular permeability via ROS-mediated calcium leakage via activated TRPM2, and via ZO-1 degradation by activated calpain.	ros	101-104	transient receptor potential cation channel subfamily M member 2	Homo sapiens	144-149
22226905-6	2012	We further identified the signaling pathway of LOX-1/Ca(2+)/ROS/ERK/c-Fos was involved in oxLDL-mediated microRNA-29b overexpression after treating with the MAPTAM (Ca(2+) chelator), NAC (ROS scavenger), U0126 (ERK inhibitor) and c-Fos (one of the AP-1 proteins) shRNA, respectively.	ros	60-63	NLR family, pyrin domain containing 1A	Mus musculus	183-186
22251375-9	2012	CONCLUSION: From these results, we conclude that JEV activates the ROS/c-Src/PDGFR/PI3K/Akt/MAPKs pathway, which in turn triggers AP-1 activation and ultimately induces MMP-9 expression in RBA-1 cells.	ros	67-70	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	130-134
22158107-13	2012	The blockade of intracellular generation of ROS by NAC (5 mmol/L) abrogated apoptosis, autophagy and the decrease of SIRT1 in the cells exposed to oridonin (7 mumol/L).	ros	44-47	X-linked Kx blood group	Homo sapiens	51-54
22158107-13	2012	The blockade of intracellular generation of ROS by NAC (5 mmol/L) abrogated apoptosis, autophagy and the decrease of SIRT1 in the cells exposed to oridonin (7 mumol/L).	ros	44-47	sirtuin 1	Homo sapiens	117-122
23052231-8	2012	RESULTS: Our findings suggested a marked increase in the Nox2 activation [i.e., ROS generation and subunit expression and activation] in cells exposed to Ws-CER.	ros	80-83	cytochrome b-245 beta chain	Rattus norvegicus	57-61
22044588-7	2012	In p53(-/-) and TIGAR(-/-) ischemic myocardium, ROS production was elevated and followed by Bnip3 activation which is an initiator of mitophagy.	ros	48-51	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	16-21
22044588-8	2012	Furthermore, the activation of Bnip3 and mitophagy due to p53/TIGAR inhibition were reversed with antioxidant N-acetyl-cysteine, indicating that this adaptive response requires ROS signal.	ros	177-180	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	62-67
22511847-7	2012	RESULTS: Compared with the BSA controls, the RGC-5 cells incubated with AGE-BSA showed a dose- and time-dependent increase in VEGF-A mRNA and VEGF-A protein secretion in the supernatant, with the highest levels achieved at 24 h. AGE-BSA stimulated a significant release of HMGB1 in the supernatant and a significant increase of intracellular ROS production at 3 h. NAC blocked HMGB1 production in a dose-dependent manner.	ros	342-345	vascular endothelial growth factor A	Mus musculus	126-132
23209736-0	2012	cFos mediates cAMP-dependent generation of ROS and rescue of maturation program in retinoid-resistant acute promyelocytic leukemia cell line NB4-LR1.	ros	43-46	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-4
23209736-4	2012	Furthermore, using RNA interference approach, we show that cFos mediates cAMP-induced ROS generation, a critical mediator of neutrophil maturation, and in fine differentiation.	ros	86-89	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	59-63
22574158-7	2012	Rather, berberine stimulated a caspase-independent cell death mediator, apoptosis-inducing factor (AIF) release from mitochondria and nuclear translocation in a ROS production-dependent manner.	ros	161-164	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	72-97
22574158-7	2012	Rather, berberine stimulated a caspase-independent cell death mediator, apoptosis-inducing factor (AIF) release from mitochondria and nuclear translocation in a ROS production-dependent manner.	ros	161-164	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	99-102
22574158-9	2012	Furthermore, two targets of ROS production in cells, cathepsin B release from lysosomes and PARP activation were induced by berberine.	ros	28-31	cathepsin B	Mus musculus	53-64
22574158-9	2012	Furthermore, two targets of ROS production in cells, cathepsin B release from lysosomes and PARP activation were induced by berberine.	ros	28-31	poly (ADP-ribose) polymerase family, member 1	Mus musculus	92-96
22574158-11	2012	Thus, berberine-stimulated ROS production leads to cathepsin B release and PARP activation-dependent AIF activation, resulting in caspase-independent cell death in colon tumor cells.	ros	27-30	cathepsin B	Mus musculus	51-62
22574158-11	2012	Thus, berberine-stimulated ROS production leads to cathepsin B release and PARP activation-dependent AIF activation, resulting in caspase-independent cell death in colon tumor cells.	ros	27-30	poly (ADP-ribose) polymerase family, member 1	Mus musculus	75-79
22574158-11	2012	Thus, berberine-stimulated ROS production leads to cathepsin B release and PARP activation-dependent AIF activation, resulting in caspase-independent cell death in colon tumor cells.	ros	27-30	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	101-104
22355787-0	2012	Particulate matter Air Pollution induces hypermethylation of the p16 promoter Via a mitochondrial ROS-JNK-DNMT1 pathway.	ros	98-101	mitogen-activated protein kinase 8	Mus musculus	102-105
21982843-8	2011	Reversal of apoptosis in both NAC- and Tempol-pretreated cells indicates the involvement of both ROS generation and GSH depletion in plumbagin- and juglone-induced apoptosis.	ros	97-100	X-linked Kx blood group	Homo sapiens	30-33
22015602-12	2011	In conclusion, our data demonstrated that hydrogen inhalation ameliorated LPS-induced ALI and it may be exerting its protective role by preventing the activation of ROS-JNK-caspase-3 pathway.	ros	165-168	caspase 3	Mus musculus	173-182
22055193-0	2011	ROS-mediated p53 induction of Lpin1 regulates fatty acid oxidation in response to nutritional stress.	ros	0-3	lipin 1	Mus musculus	30-35
21779911-6	2011	ROS scavenger NAC, caffeine and an ATM-specific inhibitor significantly reduced ARV S1133- and sigmaC-induced DNA breaks, DDIT-3 and GADD45alpha expression, H2AX phosphorylation, and apoptosis.	ros	0-3	DNA damage inducible transcript 3	Gallus gallus	122-128
21799126-9	2011	In conclusion, lung injury and apoptosis caused by preexposure to hyperoxia, followed by high tidal volume mechanical ventilation, induces ROS-mediated activation of JNK and mitochondrial-mediated apoptosis.	ros	139-142	mitogen-activated protein kinase 8	Mus musculus	166-169
21799126-10	2011	NAC protects lung injury and apoptosis by inhibiting ROS-mediated activation of JNK and downstream proapoptotic signaling.	ros	53-56	mitogen-activated protein kinase 8	Mus musculus	80-83
2836181-8	1988	However, unlike the PTH analogue, hHCF-(7-34)NH2 (8 microM) was a weak partial agonist, producing a 2.4-fold increase in cAMP (5% of the maximal response) in ROS cells.	ros	158-161	host cell factor C1	Homo sapiens	34-38
2836181-10	1988	These results demonstrate that hHCF-(7-34)NH2 interacts with PTH receptors based in large part on the region which is not homologous to PTH, and suggest the utility of the ROS 17/2.8 cell system for identifying weak agonism of PTH and hHCF analogues in vitro.	ros	172-175	host cell factor C1	Homo sapiens	31-35
2835728-4	1987	Furthermore, protease digestion of intact UR2-transformed cells removed the putative extracellular domain (the p19 portion in P68gag-ros), leaving peptide fragments (p48/p46) which conformed to the size of the ros-encoded sequence in P68.	ros	133-136	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	126-129
3785223-1	1986	A human oncogene, mcf3, previously detected by a combination of DNA-mediated gene transfer and a tumorigenicity assay, derives from a human homology of the avian v-ros oncogene.	ros	164-167	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	18-22
3937588-3	1985	PTH stimulated CKBB in the osteoblast-like clone ROS 17/2; 1 alpha,25(OH)2D3 inhibited this activity while PGE2, CT and 24R,25(OH)2D3 had no significant effect.	ros	49-52	creatine kinase B	Rattus norvegicus	15-19
3937588-4	1985	PGE2 stimulated CKBB activity in the fibroblast-like clone ROS 24/1, which was unresponsive to PTH, CT and Vitamin D metabolites.	ros	59-62	creatine kinase B	Rattus norvegicus	16-20
3937588-5	1985	24R,25(OH)2D3 as well as PGE2 (but not PTH, CT or 1 alpha 25(OH)2D3) stimulated CKBB in clone ROS 25/1, suggesting that this fibroblast-like clone has some chondroblast-like character.	ros	94-97	creatine kinase B	Rattus norvegicus	80-84
2983097-2	1985	The UR2-specific transforming sequence, ros, with a length of 1,273 nucleotides, is inserted between the truncated gag gene coding for p19 and the env gene coding for gp37 of the UR2AV helper virus.	ros	40-43	endogenous retrovirus group K member 20	Homo sapiens	147-150
6092516-1	1984	A monoclonal antibody that blocks the light-activated cyclic GMP (cGMP) pathway in frog photoreceptor outer segments (ROS) has been obtained.	ros	118-121	5'-nucleotidase, cytosolic II	Homo sapiens	61-64
6203341-1	1984	Two high-affinity monoclonal antibodies (ROS-1, ROS-2) have been produced to the rod outer segment phosphodiesterase (ROS PDE).	ros	41-44	aldehyde dehydrogenase 7 family member A1	Homo sapiens	122-125
6203341-3	1984	ROS-2 absorbs a subset of the total PDE activity from a detergent-solubilized retina extract, whereas ROS-1 adsorbs nearly all of the PDE activity.	ros	0-3	aldehyde dehydrogenase 7 family member A1	Homo sapiens	36-39
6203341-8	1984	Histone H2B activated at least 80% of the PDE activity bound to ROS-2 but was less effective in activating the PDE bound to ROS-1.	ros	64-67	aldehyde dehydrogenase 7 family member A1	Homo sapiens	42-45
6203341-9	1984	ROS-1 but not ROS-2 was an effective inhibitor of PDE activity, suggesting that ROS-1 may be a specific probe to study the effects of ROS PDE on the light response.	ros	0-3	aldehyde dehydrogenase 7 family member A1	Homo sapiens	50-53
6203341-9	1984	ROS-1 but not ROS-2 was an effective inhibitor of PDE activity, suggesting that ROS-1 may be a specific probe to study the effects of ROS PDE on the light response.	ros	0-3	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	80-85
6203341-9	1984	ROS-1 but not ROS-2 was an effective inhibitor of PDE activity, suggesting that ROS-1 may be a specific probe to study the effects of ROS PDE on the light response.	ros	0-3	aldehyde dehydrogenase 7 family member A1	Homo sapiens	138-141
33900847-0	2021	High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling.	ros	50-53	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
33665922-8	2021	Proteomic analyses, ELISA, and immunohistochemistry further revealed that myocardium of the LPS-challenged fat-1 mice demonstrated the significantly lower levels of pro-inflammatory markers and ROS than WT mice.	ros	194-197	FAT atypical cadherin 1	Mus musculus	107-112
34050453-6	2021	ROS activity assay showed that inhibiting ID2-AS1 attenuated the oxidative stress induced by 1-methy1-4-phenylpyridinium (MPP+).	ros	0-3	inhibitor of DNA binding 2	Homo sapiens	42-45
34058674-8	2021	Moreover, Rb1 ameliorated DON-inflicted oxidative stress by reducing the ROS, MDA and H2O2 contents and boosting the antioxidant defense system (T-AOC, T-SOD, CAT, and GSH-Px).	ros	73-76	RB transcriptional corepressor 1	Mus musculus	10-13
34012073-9	2021	This study not only illustrates a pyroptotic pathway linked with metabolites but also identifies an unreported principal axis extending from ROS-initiated DR6 endocytosis to caspase-8-mediated cleavage of GSDMC for potential clinical application in tumor therapy.	ros	141-144	gasdermin C	Mus musculus	205-210
33988537-10	2021	We found that mitochondrial damage and ROS levels were higher in LBP-/- rat livers than in WT rat livers at 24 h after LPS injection.	ros	39-42	lipopolysaccharide binding protein	Rattus norvegicus	65-68
33960631-4	2021	Here, we found that the blue LED irradiation significantly suppressed the proliferation, migration and invasion of human OS cells, while we observed blue LED irradiation increased ROS production through increased NADPH oxidase enzymes NOX2 and NOX4, as well as decreased Catalase (CAT) expression levels.	ros	180-183	cytochrome b-245 beta chain	Homo sapiens	235-239
33962063-0	2021	Redox sensor QSOX1 regulates plant immunity by targeting GSNOR to modulate ROS generation.	ros	75-78	quiescin sulfhydryl oxidase 1	Homo sapiens	13-18
33962063-4	2021	The expression level of QSOX1 is inversely correlated with pathogen-induced ROS accumulation.	ros	76-79	quiescin sulfhydryl oxidase 1	Homo sapiens	24-29
33962063-5	2021	QSOX1 both senses and regulates ROS levels through interaction with and redox-mediated regulation of S-nitrosoglutathione reductase that, consistent with previous findings, influences reactive nitrogen-mediated regulation of ROS generation.	ros	32-35	quiescin sulfhydryl oxidase 1	Homo sapiens	0-5
33962063-5	2021	QSOX1 both senses and regulates ROS levels through interaction with and redox-mediated regulation of S-nitrosoglutathione reductase that, consistent with previous findings, influences reactive nitrogen-mediated regulation of ROS generation.	ros	225-228	quiescin sulfhydryl oxidase 1	Homo sapiens	0-5
33962063-6	2021	Collectively, our data indicate that QSOX1 is a redox sensor that negatively regulates plant immunity by linking reactive oxygen- and reactive nitrogen-signaling to limit ROS production.	ros	171-174	quiescin sulfhydryl oxidase 1	Homo sapiens	37-42
21947960-10	2011	Finally, we showed that Sirt1 could prevent cisplatin-induced ROS accumulation in Tca8113 cells.	ros	62-65	sirtuin 1	Homo sapiens	24-29
33625952-7	2021	Our results illustrated that RIPK3 forms a complex with RIPK1, MLKL and MCU to induce mitochondrial calcium uptake and mitochondrial ROS (mROS) production during S. pneumoniae infection.	ros	133-136	receptor-interacting serine-threonine kinase 3	Mus musculus	29-34
21294650-8	2011	We observed a dose-dependent cytotoxicity and increased ROS generation, which interestingly was reversed by administration of exogenous antioxidants, NOX-2 inhibitors, and by blocking RAGE.	ros	56-59	cytochrome b-245 beta chain	Homo sapiens	150-155
33894275-1	2021	Cancer cells require increased levels of NADPH for increased nucleotide synthesis and for protection from ROS.	ros	106-109	2,4-dienoyl-CoA reductase 1	Homo sapiens	41-46
21294650-8	2011	We observed a dose-dependent cytotoxicity and increased ROS generation, which interestingly was reversed by administration of exogenous antioxidants, NOX-2 inhibitors, and by blocking RAGE.	ros	56-59	advanced glycosylation end-product specific receptor	Homo sapiens	184-188
21658760-7	2011	In vivo and in vitro studies of NAC pretreatment confirmed that iPSCs and iPSC-Heps potentially suppressed ROS production and activated antioxidant enzymes in TAA-injured livers.	ros	107-110	NLR family, pyrin domain containing 1A	Mus musculus	32-35
33900313-8	2021	Moreover, our data revealed that activation of the ROS-derived and AKT/FAK/PAK1 pathways is involved in the erinacine S-mediated transcriptional activation of Fas-L and TRAIL through H3K4 trimethylation on their promoters.	ros	51-54	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	169-174
21861928-8	2011	ROS scavenger (N-acetyl-L-cysteine, NAC) blocked the PPCSE-induced ROS generation and HO-1 expression.	ros	0-3	NLR family, pyrin domain containing 1A	Mus musculus	36-39
21861928-8	2011	ROS scavenger (N-acetyl-L-cysteine, NAC) blocked the PPCSE-induced ROS generation and HO-1 expression.	ros	67-70	NLR family, pyrin domain containing 1A	Mus musculus	36-39
21861928-9	2011	Pretreatment with selective inhibitors of PKCdelta (rottlerin) and NADPH oxidase [diphenyleneiodonium chloride (DPI) and apocynin (APO)] attenuated the PPCSE-induced NADPH oxidase activity, ROS generation, and HO-1 expression.	ros	190-193	protein kinase C, delta	Mus musculus	42-50
33968145-5	2021	Our results showed that overexpression of PPARD could inhibit inflammatory cytokine signaling pathways and the ROS and glutamate pathways that have been shown to play important roles in the pathological development of MDD.	ros	111-114	peroxisome proliferator activated receptor delta	Homo sapiens	42-47
21602054-10	2011	Apart from increased level of Granzyme A and Granzyme B, IL-15 cultured T cells exhibited increased accumulation of reactive oxygen (ROS) and reactive nitrogen species (RNS) as compared to IL-2 cultured T cells.	ros	133-136	interleukin 15	Homo sapiens	57-62
33953705-9	2021	Our results suggest that FOXO3 can be activated by metformin leading to reduced ROS/RNS level in immune cells.	ros	80-83	forkhead box O3	Mus musculus	25-30
33866462-2	2021	Importantly, recent data indicated a protective action of curcumin (CRC) via inhibition of TRPM2 on the inflammation factors, ROS, and apoptosis in hypoxia-induced SH-SY5Y neuronal cells.	ros	126-129	transient receptor potential cation channel subfamily M member 2	Homo sapiens	91-96
33857803-6	2021	SRC-3-/- mice produced more ROS and decreased L. monocytogenes-induced lymphocyte apoptosis.	ros	28-31	nuclear receptor coactivator 3	Mus musculus	0-5
21641992-6	2011	Furthermore, pretreatment with NAC, a precursor of intracellular GSH, effectively abrogated gelomulide K-induced caspase-independent cell death and autophagy, suggesting that ROS-mediated downstream signaling is essential to the anticancer effects of gelomulide K.	ros	175-178	X-linked Kx blood group	Homo sapiens	31-34
21336965-3	2011	Uncoupling Protein 3 (UCP3) gene is expressed in skeletal muscle where it regulates fatty acid metabolism, redox state, and ROS formation.	ros	124-127	uncoupling protein 3	Homo sapiens	0-20
21336965-3	2011	Uncoupling Protein 3 (UCP3) gene is expressed in skeletal muscle where it regulates fatty acid metabolism, redox state, and ROS formation.	ros	124-127	uncoupling protein 3	Homo sapiens	22-26
33897365-6	2021	Overexpression of beta-arrestin1 in the RVLM significantly decreased ROS production and facilitated the Nrf2 activation in the RVLM of SHR, accompanied by upregulating the expression of HO-1 and NQO-1.	ros	69-72	arrestin, beta 1	Rattus norvegicus	18-32
33576705-7	2021	Consistent with this, we found that Put signaling is mainly ROS dependent and partly compromised by ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), SALICYLIC ACID INDUCTION DEFICIENT 2 (SID2) and NONEXPRESSOR of PR GENES1 (NPR1) loss-of-function mutations.	ros	60-63	regulatory protein (NPR1)	Arabidopsis thaliana	189-214
33576705-7	2021	Consistent with this, we found that Put signaling is mainly ROS dependent and partly compromised by ENHANCED DISEASE SUSCEPTIBILITY1 (EDS1), SALICYLIC ACID INDUCTION DEFICIENT 2 (SID2) and NONEXPRESSOR of PR GENES1 (NPR1) loss-of-function mutations.	ros	60-63	regulatory protein (NPR1)	Arabidopsis thaliana	216-220
20354828-6	2011	In contrast, combination of simvastatin and imatinib induced a significant cell death in the subpopulation, which is dependent on the induced ROS by simvastatin as the effect was blocked by ROS scavenger N-acetyl-L: -cysteine (NAC).	ros	142-145	X-linked Kx blood group	Homo sapiens	227-230
20354828-6	2011	In contrast, combination of simvastatin and imatinib induced a significant cell death in the subpopulation, which is dependent on the induced ROS by simvastatin as the effect was blocked by ROS scavenger N-acetyl-L: -cysteine (NAC).	ros	190-193	X-linked Kx blood group	Homo sapiens	227-230
33444648-3	2021	Since mitochondria are the main oxygen sensors as well as the principal producers of ROS, it can be presumed that they may be able to modulate the activity of CRL3KEAP1 and CRL2VHL complexes in response to stress.	ros	85-88	DAN domain BMP antagonist family member 5	Homo sapiens	173-180
21335603-11	2011	HIF-1alpha-hydroxylation-dependent VHL pull-down assay showed that Src inhibits cellular PHD2 activity by inducing ROS production in a mechanism involving Rac1-dependent NADPH oxidase.	ros	115-118	Rac family small GTPase 1	Homo sapiens	155-159
21318222-10	2011	Hence, our findings are consistent with a possible role of HDAC inhibitor mediated-ROS induction in RR inhibition and in the potentiation of RR inhibitor-mediated apoptosis.	ros	83-86	histone deacetylase 9	Homo sapiens	59-63
33486313-8	2021	Mechanistically, suppression of ROS/NFkappaB signaling pathway by increasing fatty acid oxidation-derived NADPH production was involved in the anti-tumorigenic functions of CPT2 in OC cells.	ros	32-35	2,4-dienoyl-CoA reductase 1	Homo sapiens	106-111
33741719-6	2021	RNA sequencing revealed that mGPDH regulated the RAGE signaling pathway, and inhibition of RAGE or its ligand, S100A10, protected against the impaired mitochondrial bioenergetics and increased ROS generation caused by mGPDH knockdown in cultured podocytes.	ros	193-196	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	29-34
33741719-6	2021	RNA sequencing revealed that mGPDH regulated the RAGE signaling pathway, and inhibition of RAGE or its ligand, S100A10, protected against the impaired mitochondrial bioenergetics and increased ROS generation caused by mGPDH knockdown in cultured podocytes.	ros	193-196	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	218-223
21233411-1	2011	Neutrophils play a fundamental role in host defense by neutralizing pathogens through the generation of ROS by NOX2.	ros	104-107	cytochrome b-245 beta chain	Homo sapiens	111-115
33850858-7	2021	Intracellular ROS production was determined by measuring uptake of dichlorodihydrofluorescein diacetate (DCFH-DA; PCR was used to assay the mRNA expression of STAT3 gene bearing predicted targeting positions for miR-495, while qRT-PCR was used to measure miR-495 mRNA.	ros	14-17	microRNA 495	Mus musculus	212-219
33850858-7	2021	Intracellular ROS production was determined by measuring uptake of dichlorodihydrofluorescein diacetate (DCFH-DA; PCR was used to assay the mRNA expression of STAT3 gene bearing predicted targeting positions for miR-495, while qRT-PCR was used to measure miR-495 mRNA.	ros	14-17	microRNA 495	Mus musculus	255-262
33838628-11	2021	Interestingly, the treatment with HDC, a specific NOX-2 inhibitor, reduced the ROS levels in HCT-116/R cells.	ros	79-82	cytochrome b-245 beta chain	Homo sapiens	50-55
21300075-0	2011	Rb1 postconditioning attenuates liver warm ischemia-reperfusion injury through ROS-NO-HIF pathway.	ros	79-82	RB transcriptional corepressor 1	Mus musculus	0-3
21300075-15	2011	These findings suggested Rb1 may have the therapeutic potential through ROS-NO-HIF pathway for management of liver warm I/R injury.	ros	72-75	RB transcriptional corepressor 1	Mus musculus	25-28
33432610-2	2021	NOD-like receptor X1 (NLRX1) is located in the mitochondria and is highly expressed in the intestine, and is known to modulate ROS production, mitochondrial damage, autophagy and apoptosis.	ros	127-130	NLR family member X1	Rattus norvegicus	0-20
21266576-5	2011	Moreover, we show that HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling in both SkBr3 and HL-1 and cells.	ros	173-176	G protein-coupled estrogen receptor 1	Homo sapiens	92-96
21266576-5	2011	Moreover, we show that HIF-1alpha-responsive elements located within the promoter region of GPER are involved in hypoxia-dependent transcription of GPER, which requires the ROS-induced activation of EGFR/ERK signaling in both SkBr3 and HL-1 and cells.	ros	173-176	G protein-coupled estrogen receptor 1	Homo sapiens	148-152
21268080-4	2011	Moreover, CSE also induced c-Jun and c-Fos expression, which were inhibited by pretreatment with the inhibitors of NADPH oxidase (diphenyleneiodonium chloride and apocynin) and the ROS scavenger (N-acetyl-L-cysteine) or transfection with siRNAs of p47(phox) and NADPH oxidase (NOX)2.	ros	181-184	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-32
21268080-4	2011	Moreover, CSE also induced c-Jun and c-Fos expression, which were inhibited by pretreatment with the inhibitors of NADPH oxidase (diphenyleneiodonium chloride and apocynin) and the ROS scavenger (N-acetyl-L-cysteine) or transfection with siRNAs of p47(phox) and NADPH oxidase (NOX)2.	ros	181-184	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	37-42
33432610-2	2021	NOD-like receptor X1 (NLRX1) is located in the mitochondria and is highly expressed in the intestine, and is known to modulate ROS production, mitochondrial damage, autophagy and apoptosis.	ros	127-130	NLR family member X1	Rattus norvegicus	22-27
33359576-9	2021	In this study, the regulation mechanism of the ROS-hnRNP A2/B1-COX-2 pathway on DU-induced reproductive damage in male rats was hypothesized, providing a new target for the prevention and treatment of chronic poisoning of DU.	ros	47-50	heterogeneous nuclear ribonucleoprotein A2/B1	Rattus norvegicus	51-62
21325819-5	2011	Interestingly, ROS production in the aorta was only increased in the LDLR(-/-) +cholesterol group (0.17+-0.04 and 0.16+-0.05 in the control groups, 0.14+-0.02 vs. 0.34+-0.06 in the LDLR(-/-) groups, p&lt;0.05).	ros	15-18	low density lipoprotein receptor	Mus musculus	69-73
33578778-4	2021	(3) Results: PRR is expressed in all the tumour subtypes, with higher mean staining intensity in ChRCCs and ROs.	ros	108-111	ATPase H+ transporting accessory protein 2	Homo sapiens	13-16
21325819-5	2011	Interestingly, ROS production in the aorta was only increased in the LDLR(-/-) +cholesterol group (0.17+-0.04 and 0.16+-0.05 in the control groups, 0.14+-0.02 vs. 0.34+-0.06 in the LDLR(-/-) groups, p&lt;0.05).	ros	15-18	low density lipoprotein receptor	Mus musculus	181-185
33540918-8	2021	HG-induced EndMT appears to be mediated by NADPH-associated ROS generation as pre-treatment of HRECs with resveratrol or the NADPH inhibitor, diphenyleneiodonium chloride (DPI), attenuated ROS production and EndMT transition, suggesting that the effect of resveratrol on HG-induced ROS occurs via down-regulation of NADPH oxidase.	ros	60-63	2,4-dienoyl-CoA reductase 1	Homo sapiens	43-48
21073737-6	2010	Cancer cells with disruption of both HIF-1alpha and HIF-2alpha or oncogenic KRAS showed decreased aerobic respiration and ATP production, with increased ROS generation.	ros	153-156	KRAS proto-oncogene, GTPase	Homo sapiens	76-80
33540918-8	2021	HG-induced EndMT appears to be mediated by NADPH-associated ROS generation as pre-treatment of HRECs with resveratrol or the NADPH inhibitor, diphenyleneiodonium chloride (DPI), attenuated ROS production and EndMT transition, suggesting that the effect of resveratrol on HG-induced ROS occurs via down-regulation of NADPH oxidase.	ros	189-192	2,4-dienoyl-CoA reductase 1	Homo sapiens	43-48
33540918-8	2021	HG-induced EndMT appears to be mediated by NADPH-associated ROS generation as pre-treatment of HRECs with resveratrol or the NADPH inhibitor, diphenyleneiodonium chloride (DPI), attenuated ROS production and EndMT transition, suggesting that the effect of resveratrol on HG-induced ROS occurs via down-regulation of NADPH oxidase.	ros	189-192	2,4-dienoyl-CoA reductase 1	Homo sapiens	125-130
33540918-8	2021	HG-induced EndMT appears to be mediated by NADPH-associated ROS generation as pre-treatment of HRECs with resveratrol or the NADPH inhibitor, diphenyleneiodonium chloride (DPI), attenuated ROS production and EndMT transition, suggesting that the effect of resveratrol on HG-induced ROS occurs via down-regulation of NADPH oxidase.	ros	189-192	2,4-dienoyl-CoA reductase 1	Homo sapiens	125-130
20547144-4	2010	Cell cultures show that R492X PINK1 mutation induces the generation of cellular reactive oxidative species (ROS), degrades cell membrane potential, causes cytochrome C (Cyt.C) release from mitochondrial to cytoplasm, attenuates mitochondrial complex I activity, and lastly, causes changes in mitochondrial numbers and morphology; especially when cells are treated with 1-Methyl-4-phenylpyridinium ion (MPP(+)).	ros	108-111	PTEN induced kinase 1	Homo sapiens	30-35
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	ros	116-119	matrix metallopeptidase 9	Homo sapiens	56-61
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	ros	116-119	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	148-153
33540918-9	2021	It is worth noting that resveratrol or Chelerythrine, a Protein kinase C (PKC) inhibitor, reduce ROS and EndMT in HG-exposed cells, suggesting that NADPH activation occurs via a PKC-dependent mechanism.	ros	97-100	2,4-dienoyl-CoA reductase 1	Homo sapiens	148-153
32979141-5	2021	Quantitative real-time PCR and western blot analysis demonstrated that drug combination-induced mitochondrial apoptosis was activated through the ROS-mediated PERK/eIF2alpha/ATF4/CHOP pathway.	ros	146-149	eukaryotic translation initiation factor 2A	Homo sapiens	164-173
32979141-5	2021	Quantitative real-time PCR and western blot analysis demonstrated that drug combination-induced mitochondrial apoptosis was activated through the ROS-mediated PERK/eIF2alpha/ATF4/CHOP pathway.	ros	146-149	activating transcription factor 4	Homo sapiens	174-178
20432471-0	2010	Caffeine induces matrix metalloproteinase-2 (MMP-2) and MMP-9 down-regulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-fos pathway and activation of p38 MAPK/c-jun pathway.	ros	116-119	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	189-194
20432471-2	2010	Down-regulation of MMP-2 and MMP-9 in U937 cells was abrogated by abolishment of caffeine-elicited increase in intracellular Ca(2+) concentration and ROS generation.	ros	150-153	matrix metallopeptidase 9	Homo sapiens	29-34
33230666-9	2021	We confirmed that the overexpression of TR1 in neuronal cells decreased DNA damage and malondialdehyde (MDA) and ROS generation, increased T-SOD and GSH production, and decreased the ER stress, and autophagy in the PD model.	ros	113-116	thioredoxin reductase 1	Mus musculus	40-43
20602492-5	2010	Evidence is provided to demonstrate that GPD2 activity is required for ROS generation in mouse spermatozoa during capacitation, failing which, capacitation is impaired.	ros	71-74	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	41-45
33095436-5	2021	ROS-dependent effect of thymol was confirmed using NAC.	ros	0-3	X-linked Kx blood group	Homo sapiens	51-54
33148527-10	2021	On the whole, our present study suggested that 1] ROS could modify H3K9 methylation via G9a and promote radiation-induced lung EMT in Beas2B and A549 cells 2] E-cadherin promoter enrichment with heterochromatin mark H3K9me2 expression upon irradiation could be modified by regulating G9a methyltransferase.	ros	50-53	euchromatic histone lysine methyltransferase 2	Homo sapiens	88-91
20534110-15	2010	Pretreatment with NAC blocked BITC and PEITC induced ROS elevation and NFkappaB inhibition.	ros	53-56	X-linked Kx blood group	Homo sapiens	18-21
33427275-5	2021	Furthermore, TTRh-CN can efficiently produce ROS in conjunction with lysosomes in situ upon light irradiation, which can damage lysosomes, up-regulate LC3 and Beclin1, increase BAX release, and induce cell apoptosis.	ros	45-48	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	151-154
20548951-0	2010	The E1A-associated p400 protein modulates cell fate decisions by the regulation of ROS homeostasis.	ros	83-86	E1A binding protein p400	Homo sapiens	19-23
20548951-2	2010	Here, we show that p400 expression is required for the correct control of ROS metabolism.	ros	74-77	E1A binding protein p400	Homo sapiens	19-23
20548951-3	2010	Depletion of p400 indeed increases intracellular ROS levels and causes the appearance of DNA damage, indicating that p400 maintains oxidative stress below a threshold at which DNA damages occur.	ros	49-52	E1A binding protein p400	Homo sapiens	13-17
20548951-3	2010	Depletion of p400 indeed increases intracellular ROS levels and causes the appearance of DNA damage, indicating that p400 maintains oxidative stress below a threshold at which DNA damages occur.	ros	49-52	E1A binding protein p400	Homo sapiens	117-121
20548951-5	2010	Finally, we show that these effects of p400 are dependent on direct transcriptional regulation of specific promoters and may also involve a positive feedback loop between oxidative stress and DNA breaks since we found that persistent DNA breaks are sufficient to increase ROS levels.	ros	272-275	E1A binding protein p400	Homo sapiens	39-43
33427275-5	2021	Furthermore, TTRh-CN can efficiently produce ROS in conjunction with lysosomes in situ upon light irradiation, which can damage lysosomes, up-regulate LC3 and Beclin1, increase BAX release, and induce cell apoptosis.	ros	45-48	beclin 1	Homo sapiens	159-166
20548951-6	2010	Altogether, our results uncover an unexpected link between p400 and ROS metabolism and allow deciphering the molecular mechanisms largely responsible for cell proliferation control by p400.	ros	68-71	E1A binding protein p400	Homo sapiens	59-63
33574981-4	2021	In addition, the apelin/APJ-manipulated CaMKK/AMPK/GSK3beta-dependent mechanism improves HUVECs" resistance to oxygen and glucose deprivation/reperfusion (OGD/R), reduces ROS production and accumulation, maintained the normal mitochondrial membrane potential, and suppresses oxidative stress in vitro.	ros	171-174	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	46-50
20203069-5	2010	Furthermore, oxLDL rapidly activated the membrane translocation of Rac-1 and p47phox and the subsequent induction of ROS generation, which was suppressed markedly by pretreatment with EGCG or anti-LOX-1 monoclonal antibody.	ros	117-120	Rac family small GTPase 1	Homo sapiens	67-72
20203069-5	2010	Furthermore, oxLDL rapidly activated the membrane translocation of Rac-1 and p47phox and the subsequent induction of ROS generation, which was suppressed markedly by pretreatment with EGCG or anti-LOX-1 monoclonal antibody.	ros	117-120	neutrophil cytosolic factor 1	Homo sapiens	77-84
33383564-8	2021	Our results demonstrate that the donor of H2S inhibits NETs formation of neutrophils via the HMGB1/TLR4/p38 MAPK/ROS pathway in hyperhomocysteinemia.	ros	113-116	high mobility group box 1	Rattus norvegicus	93-98
20171273-3	2010	Here, to further investigate the role of HIPK2 in p53 activation, we started with the finding that HIPK2 inhibition upregulated Nox1, a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase, involved in tumor progression and ROS production.	ros	247-250	homeodomain interacting protein kinase 2	Homo sapiens	99-104
33499185-6	2021	Additionally, 5-DN efficiently counteracted and equilibrated the production of ROS accelerated by CCl4 and dramatically downregulated the expression of CYP2E1 vitally involved in converting CCl4 to toxic free radicals and also enhanced the antioxidant enzymes.	ros	79-82	chemokine (C-C motif) ligand 4	Mus musculus	98-102
33310292-5	2021	Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-l-cysteine (NAC) clearing ROS delayed GSCs apoptosis.	ros	113-116	neutrophil cytosolic factor 1	Homo sapiens	85-89
20060027-7	2010	Our data suggest that involvement of TSPO in oxidative stress and ROS generation, as reported in other studies, may also take part in atherogenesis as induced by HFHC diet.	ros	66-69	translocator protein	Rattus norvegicus	37-41
20117097-3	2010	Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 suppression is related to the development of airway inflammation and increased ROS levels.	ros	149-152	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	0-69
33310292-5	2021	Further investigation suggested that tribulosaponin A up-regulated the expression of NCF1 and NOX1 to accumulate ROS for triggering apoptosis in GSCs, but not in untransformed cells, and it was further supported by the assay that N-acetyl-l-cysteine (NAC) clearing ROS delayed GSCs apoptosis.	ros	265-268	neutrophil cytosolic factor 1	Homo sapiens	85-89
33519423-8	2020	Western blotting revealed a decrease in cleaved caspase-9 and caspase-3 expression in line with ROS levels.	ros	96-99	caspase 3	Mus musculus	62-71
33505580-6	2021	Then, after coculture with CaSR-stimulated PMNs, the expression of Bcl-xl in cardiomyocytes significantly increased, Bax expression and the apoptotic rate decreased, and ROS production was significantly inhibited.	ros	170-173	calcium-sensing receptor	Rattus norvegicus	27-31
33397952-4	2021	Autocrine IL11 activity causes hepatocyte death through NOX4-derived ROS, activation of ERK, JNK and caspase-3, impaired mitochondrial function and reduced fatty acid oxidation.	ros	69-72	interleukin 11	Mus musculus	10-14
33397994-5	2021	IR-61 inhibits the classical activation of ATMs by increasing mitochondrial complex levels and oxidative phosphorylation via the ROS/Akt/Acly pathway.	ros	129-132	ATP citrate lyase	Homo sapiens	137-141
33028955-9	2021	SLC38A2 knockdown decreased Gln consumption, inhibited cell growth, induced autophagy and led to ROS production in a subgroup of Gln-sensitive cell lines.	ros	97-100	solute carrier family 38 member 2	Homo sapiens	0-7
33452978-2	2021	Inhibitors of NHE-1 zoniporide (1 mg/kg intraperitoneally, 13 days) and BMA-1321 compound (0.92 mg/kg intraperitoneally, 13 days) improved the mitochondrial function in rats with isoproterenol-induced cardiac failure: respiratory control coefficients increased, more so for the respiratory chain complex II, the main source of ROS in heart failure.	ros	327-330	solute carrier family 9 member A1	Rattus norvegicus	14-19
33246054-7	2021	Moreover, our data revealed that multiple signaling pathways were involved in the H3K4 trimethylation of TNFR1 and TRAIL proteins by CIL-102, including ROS-derived and JNK/mTOR/p300 pathways in gastric cancer AGS cells.	ros	152-155	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	115-120
33197464-8	2020	Our data proved that: (i) the rise of mitochondrial ROS determines a very rapid translocation of APE1 from the intermembrane space (IMS) into the matrix; and (ii) TIM23/PAM machinery complex is responsible for the matrix translocation of APE1.	ros	52-55	translocase of inner mitochondrial membrane 23	Homo sapiens	163-168
33197464-8	2020	Our data proved that: (i) the rise of mitochondrial ROS determines a very rapid translocation of APE1 from the intermembrane space (IMS) into the matrix; and (ii) TIM23/PAM machinery complex is responsible for the matrix translocation of APE1.	ros	52-55	peptidylglycine alpha-amidating monooxygenase	Homo sapiens	169-172
32979364-0	2020	Indoxyl sulfate promotes osteogenic differentiation of vascular smooth muscle cells by miR-155-5p-dependent downregulation of matrix Gla protein via ROS/NF-kappaB signaling.	ros	149-152	microRNA 155	Homo sapiens	87-94
32979364-8	2020	In vitro, IS suppressed MGP expression in HASMCs by activating ROS/NF-kappaB signaling in parallel with osteogenic differentiation, which was mitigated by inhibiting ROS and NF-kappaB with diphenyleneiodonium and Bay11-7082.	ros	63-66	matrix Gla protein	Rattus norvegicus	24-27
32656613-14	2020	The results showed that exogenous rHO1 could significantly upgrade the mRNA expression of HO1 and hepcidin, coupled with increased ROS and T-AOC levels.	ros	131-134	heme oxygenase 1	Rattus norvegicus	34-38
32656613-14	2020	The results showed that exogenous rHO1 could significantly upgrade the mRNA expression of HO1 and hepcidin, coupled with increased ROS and T-AOC levels.	ros	131-134	heme oxygenase 1	Rattus norvegicus	35-38
33231561-10	2020	LINC00052 decreased hypoxia-induced ROS and MDA accumulation in vitro and increased SOD activity.	ros	36-39	long intergenic non-protein coding RNA 52	Homo sapiens	0-9
33294260-5	2020	Meanwhile, Chiauranib increases ROS production in KRAS wild-type CRC cells.	ros	32-35	KRAS proto-oncogene, GTPase	Homo sapiens	50-54
33294260-7	2020	Mechanistically, Chiauranib inhibits KRAS wild-type CRC cells by triggering ROS production via activating the p53 signaling pathway.	ros	76-79	KRAS proto-oncogene, GTPase	Homo sapiens	37-41
33294260-8	2020	Further, KRAS mutation CRC cells are resistant to Chiauranib by increasing Nrf2 to stably elevate the basal antioxidant program and thereby lower intracellular ROS induced by Chiauranib.	ros	160-163	KRAS proto-oncogene, GTPase	Homo sapiens	9-13
33268575-19	2020	CONCLUSIONS: After I/R, HIF-1alpha up-regulates the expression of PGC1alpha, leading to an increase in ROS production and aggravation of injury.	ros	103-106	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	24-34
33204320-18	2020	Also, EBV encoded driving protein LMP1 promotes EBV reactivation through production of ROS.	ros	87-90	PDZ and LIM domain 7	Homo sapiens	34-38
32758622-9	2020	KEY FINDINGS: Bufothionine inhibited cell viability, triggered ER stress and promoted ROS production in GC cells, and both ER stress inhibitor Salburinal (Sal) and ROS scavenger (NAC) abrogated Bufothionine induced GC cell death.	ros	164-167	NLR family, pyrin domain containing 1A	Mus musculus	179-182
32800851-9	2020	After enhancing miR-23a-5p expression or silencing PPARalpha gene, H/R-caused cell damage was further aggravated compared with NC group, and ROS level was increased associated with the decreased levels of FOXO3alpha, PGC-1alpha, Nrf2, CAT, NQO1, HO-1 and SOD2.	ros	141-144	NAD(P)H dehydrogenase, quinone 1	Mus musculus	240-244
32800233-2	2020	In the present study, we assessed F induced oxidative stress through monitoring biochemical parameters and looked into the effect of chronic F exposure on two crucial DNA repair genes Ogg1 and Rad51 having important role against ROS induced DNA damages.	ros	229-232	8-oxoguanine DNA-glycosylase 1	Mus musculus	184-188
32803470-7	2020	We also discovered that downregulation of SETD6 suppressed GLU and PA-induced ROS generation and podocyte mitochondrial dysfunction.	ros	78-81	SET domain containing 6	Mus musculus	42-47
32591281-0	2020	Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.	ros	105-108	zinc finger protein 36	Mus musculus	48-63
32780724-8	2020	Furthermore, genetic deficiency of autophagy element FIP200 resulted in Tim-4+ TAM loss via ROS-mediated apoptosis, and elevated T cell-immunity and ID8 tumor inhibition in vivo.	ros	92-95	RB1 inducible coiled-coil 1	Homo sapiens	53-59
19941472-6	2010	In vitro studies have suggested that the neuroprotective role of Nb may be due to its ability to scavenge reactive oxygen (ROS) and nitrogen (RNS) species.	ros	123-126	neuroglobin	Homo sapiens	65-67
32967483-5	2020	Histidine-rich glycoprotein (HRG), a plasma glycoprotein, ameliorates a septic condition through the suppression of both excess ROS production from neutrophils and immunothrombosis.	ros	128-131	histidine rich glycoprotein	Homo sapiens	0-27
19720122-0	2009	Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway.	ros	89-92	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-126
19720122-0	2009	Arachidonic acid induces Fas and FasL upregulation in human leukemia U937 cells via Ca2+/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2 pathway.	ros	89-92	activating transcription factor 2	Homo sapiens	162-167
19720122-9	2009	Taken together, our data indicate that Fas/FasL upregulation in AA-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas-mediated apoptotoic mechanism is involved in AA-induced cell death.	ros	108-111	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	140-145
19720122-9	2009	Taken together, our data indicate that Fas/FasL upregulation in AA-treated U937 cells is elicited by Ca(2+)/ROS-mediated suppression of ERK/c-Fos pathway and activation of p38 MAPK/ATF-2, and suggest that autocrine Fas-mediated apoptotoic mechanism is involved in AA-induced cell death.	ros	108-111	activating transcription factor 2	Homo sapiens	181-186
32967483-5	2020	Histidine-rich glycoprotein (HRG), a plasma glycoprotein, ameliorates a septic condition through the suppression of both excess ROS production from neutrophils and immunothrombosis.	ros	128-131	histidine rich glycoprotein	Homo sapiens	29-32
32967483-6	2020	Hydroxyl radical is known as the most important species among ROS in pathogenesis; however, the direct influence of HRG on hydroxyl radical formation and ROS activity is poorly understood.	ros	154-157	histidine rich glycoprotein	Homo sapiens	116-119
32967483-12	2020	Thus, the present study provides evidence that inhibition of ROS and ROS-production systems by HRG may contribute to anti-septic effects in vivo and that HRG could be potential therapy for ROS-related diseases.	ros	61-64	histidine rich glycoprotein	Homo sapiens	95-98
32967483-12	2020	Thus, the present study provides evidence that inhibition of ROS and ROS-production systems by HRG may contribute to anti-septic effects in vivo and that HRG could be potential therapy for ROS-related diseases.	ros	69-72	histidine rich glycoprotein	Homo sapiens	95-98
32967483-12	2020	Thus, the present study provides evidence that inhibition of ROS and ROS-production systems by HRG may contribute to anti-septic effects in vivo and that HRG could be potential therapy for ROS-related diseases.	ros	69-72	histidine rich glycoprotein	Homo sapiens	95-98
32705170-4	2020	In the present study, it was found dicoumarol (DIC) reduced the phosphorylation of pyruvate dehydrogenase (PDH) by inhibiting the activity of PDK1, which converted the metabolism of human hepatocellular carcinoma (HCC) cells to oxidative phosphorylation, leading to an increase in mitochondrial reactive oxygen species ROS (mtROS) and a decrease in mitochondrial membrane potential (MMP), thereby increasing the apoptosis induced by oxaliplatin (OXA).	ros	319-322	pyruvate dehydrogenase kinase 1	Homo sapiens	142-146
19557855-8	2009	CHM-1-induced apoptosis was associated with enhanced ROS generation, DNA damage, decreased DeltaPsi(m) levels, and promotion of mitochondrial cytochrome c release.	ros	53-56	chondromodulin	Homo sapiens	0-5
32729895-8	2020	Accordingly, CD133+CD44+ cells contained lower ROS levels than CD133-CD44- cells, and the low ROS levels in CD133+CD44+ cells were related to the enhancement of antioxidant defense systems.	ros	47-50	CD44 molecule (Indian blood group)	Homo sapiens	19-23
19821085-3	2009	X-ray repair cross-complementing group 1 (XRCC1), a base excision repair protein, has multiple roles in repairing ROS-mediated, basal DNA damage and single-strand DNA breaks.	ros	114-117	X-ray repair cross complementing 1	Homo sapiens	0-40
32849424-4	2020	The lethal effects of chemerin are enhanced by bacterial-derived ROS-induced chemerin peptide oxidation and suppressed by stationary phase sigma factor RpoS.	ros	65-68	retinoic acid receptor responder 2	Homo sapiens	22-30
19821085-3	2009	X-ray repair cross-complementing group 1 (XRCC1), a base excision repair protein, has multiple roles in repairing ROS-mediated, basal DNA damage and single-strand DNA breaks.	ros	114-117	X-ray repair cross complementing 1	Homo sapiens	42-47
19652361-6	2009	In primary cultures of cardiomyocytes, Sirt3 blocked cardiac hypertrophy by activating the forkhead box O3a-dependent (Foxo3a-dependent), antioxidant-encoding genes manganese superoxide dismutase (MnSOD) and catalase (Cat), thereby decreasing cellular levels of ROS.	ros	262-265	forkhead box O3	Mus musculus	119-125
32849424-4	2020	The lethal effects of chemerin are enhanced by bacterial-derived ROS-induced chemerin peptide oxidation and suppressed by stationary phase sigma factor RpoS.	ros	65-68	retinoic acid receptor responder 2	Homo sapiens	77-85
19481953-2	2009	The results indicated that PCF, ROS scavenger NAC and NF-kappaB inhibitor MG132 effectively inhibited UVB-induced HaCaT cells apoptosis.	ros	32-35	X-linked Kx blood group	Homo sapiens	46-49
32848720-8	2020	Moreover, our results demonstrated that 1alpha,25(OH)2D3 promoted the ROS level via activating NADPH oxidase complexes, NOX4, p22phox, and p47phox.	ros	70-73	cytochrome b-245, alpha polypeptide	Mus musculus	126-133
19481953-5	2009	Additionally, pretreatment with NAC significantly declined the generation of ROS and the expression of p-NF-kappaB/p65.	ros	77-80	X-linked Kx blood group	Homo sapiens	32-35
32697084-6	2020	The miR156 targeting SPL, miR164 targeting NAC, miR319 targeting TCP4, GAMYB, and acyl-CoA-binding protein 4, and miR6478 targeting patatin-like protein 2 might play important roles in the browning inhibition of fresh-cut apples by H2S via regulating the ROS, phenylpropanoid, and lipid metabolism.	ros	255-258	patatin-like protein 2	Malus domestica	132-154
19820329-5	2009	Taken together, our data suggest MKK5 functions both in ozone-induced activation of MPK3 and MPK6 and in integrating ROS homeostasis during ozone stress.	ros	117-120	MAP kinase kinase 5	Arabidopsis thaliana	33-37
19364500-6	2009	Notably, levels of ROS were rapidly increased upon UV-irradiation and the ROS scavenger NAC inhibits UV-induced senescence of Akt1(-/-) MEFs, suggesting that UV light induces premature senescence in Akt1(-/-) MEFs by modulating intracellular levels of ROS.	ros	74-77	NLR family, pyrin domain containing 1A	Mus musculus	88-91
32446885-6	2020	Furthermore, in vitro studies with HPMVECs confirmed that midazolam inhibited VEGF-induced intracellular events including ROS generation, TGase activation, and disruption of vascular endothelial-cadherins, thus preventing the permeability of endothelial cells.	ros	122-125	vascular endothelial growth factor A	Mus musculus	78-82
19413946-2	2009	Accordingly, it was proposed that UCP2 and UCP3 are also uncoupling proteins i.e. protonophores with impact on mitochondrial ROS production and glucose signaling.	ros	125-128	uncoupling protein 3	Homo sapiens	43-47
32765680-10	2020	Notably, transfection of p47phox siRNA attenuated the generation of ROS and the activation of NADPH oxidase.	ros	68-71	neutrophil cytosolic factor 1	Homo sapiens	25-32
19439224-0	2009	Multifaceted CFTR: novel role in ROS signaling and apoptotic cell death--a commentary on "CFTR mediates cadmium-induced apoptosis through modulation of ROS levels in mouse proximal tubule cells".	ros	33-36	cystic fibrosis transmembrane conductance regulator	Mus musculus	13-17
19439224-0	2009	Multifaceted CFTR: novel role in ROS signaling and apoptotic cell death--a commentary on "CFTR mediates cadmium-induced apoptosis through modulation of ROS levels in mouse proximal tubule cells".	ros	33-36	cystic fibrosis transmembrane conductance regulator	Mus musculus	90-94
19439224-0	2009	Multifaceted CFTR: novel role in ROS signaling and apoptotic cell death--a commentary on "CFTR mediates cadmium-induced apoptosis through modulation of ROS levels in mouse proximal tubule cells".	ros	152-155	cystic fibrosis transmembrane conductance regulator	Mus musculus	13-17
19439224-0	2009	Multifaceted CFTR: novel role in ROS signaling and apoptotic cell death--a commentary on "CFTR mediates cadmium-induced apoptosis through modulation of ROS levels in mouse proximal tubule cells".	ros	152-155	cystic fibrosis transmembrane conductance regulator	Mus musculus	90-94
18801380-1	2009	OBJECTIVE: Vascular endothelial cells (ECs) are constantly exposed to blood flow associated forces such as cyclic strain due to blood pressure, which affects ECs survival and angiogenesis by producing ROS via NAD(P)H oxidase.	ros	201-204	2,4-dienoyl-CoA reductase 1	Homo sapiens	209-216
32399954-5	2020	We hypothesize that SARS-Cov-2 may induce myocardial injury via Nox2-related ROS production and that analysis and eventually targeting Nox2 may be a novel approach to manage SARS-CoV-2.	ros	77-80	cytochrome b-245 beta chain	Homo sapiens	64-68
32558367-7	2020	Meanwhile, ROS production regulated by UCP2 levels also contributed to NLRP3 inflammasome assembly and subsequent caspase 1 activation and mature IL-1beta secretion.	ros	11-14	uncoupling protein 2	Rattus norvegicus	39-43
19825614-5	2009	Despite the increased presence of the AOX1D isoform in the mutant, antimycin A caused inhibition of photosynthesis, increased ROS, and ultimately resulted in amplified membrane leakage and necrosis when compared to the wild-type, which was only marginally affected by the inhibitor.	ros	126-129	alternative oxidase 1D	Arabidopsis thaliana	38-43
19009558-2	2009	Upon exposure to PLA(2), p38 MAPK activation, ERK inactivation, ROS generation, increase in intracellular Ca(2+) concentration, and upregulation of Fas and FasL were found in SK-N-SH cells.	ros	64-67	phospholipase A2 group IIA	Homo sapiens	17-23
19009558-8	2009	Taken together, our results indicate that PLA(2)-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca(2+)- and ROS-evoked p38 MAPK activation, and suggest that non-catalytic PLA(2) plays a role for the signaling pathway.	ros	157-160	phospholipase A2 group IIA	Homo sapiens	42-48
32558367-7	2020	Meanwhile, ROS production regulated by UCP2 levels also contributed to NLRP3 inflammasome assembly and subsequent caspase 1 activation and mature IL-1beta secretion.	ros	11-14	caspase 1	Rattus norvegicus	114-123
19009558-8	2009	Taken together, our results indicate that PLA(2)-induced cell death is, in part, elicited by upregulation of Fas and FasL, which is regulated by Ca(2+)- and ROS-evoked p38 MAPK activation, and suggest that non-catalytic PLA(2) plays a role for the signaling pathway.	ros	157-160	phospholipase A2 group IIA	Homo sapiens	220-226
32626998-8	2020	In conclusion, the results from the present study suggested that ERO1alpha knockdown may protect H9C2 cardiomyocytes from H/R injury through inhibiting intracellular ROS production and increasing intracellular levels of Ca2+, suggesting that ERO1alpha may serve an important role in H/R.	ros	166-169	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	65-74
19292057-9	2009	Compared to TGF-beta1-induced group, G-Rb1 and DPI depressed TGF-beta1-induced ROS production and p47phox overexpression.	ros	79-82	RB transcriptional corepressor 1	Rattus norvegicus	39-42
19292057-11	2009	CONCLUSION: G-Rb1 could inhibit TGF-beta1 induced ROS production and decrease the levels of Col-I and FN in a dose-dependent manner.	ros	50-53	RB transcriptional corepressor 1	Rattus norvegicus	14-17
32736659-10	2020	In addition, hBMSCs treated with 100 ng/ml HGF and 10 ng/ml SCF had reduced ROS levels and preserved mitochondrial membrane potential compared with P8 hBMSCs during long-term expansion.	ros	76-79	KIT ligand	Homo sapiens	60-63
32774667-10	2020	With the downregulation of Cx43 expression, the activity of PKC-alpha and its related NOX2/ROS signaling pathway were reduced.	ros	91-94	cytochrome b-245 beta chain	Homo sapiens	86-90
18651560-7	2008	Our results show that IH-induced HIF-1alpha accumulation is due to increased generation of ROS by NADPH oxidase.	ros	91-94	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	33-43
32169699-6	2020	The involvement of autophagy was further confirmed because the cytotoxicity profile can be increased or reduced by the use of 3-MA (autophagy inhibitor) and NAC (ROS inhibitor), respectively.	ros	162-165	NLR family, pyrin domain containing 1A	Mus musculus	157-160
18651560-8	2008	We further demonstrate that ROS-dependent Ca(2+) signaling pathways involving phospholipase Cgamma (PLCgamma) and protein kinase C activation are required for IH-evoked HIF-1alpha accumulation.	ros	28-31	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	169-179
18802921-6	2008	Introduction of hrVEGF(165) initiated ROS-mediated intracellular signaling, resulting in kinase activation and phosphorylation of KDR and Erk1/2.	ros	38-41	kinase insert domain receptor	Homo sapiens	130-133
32635976-4	2020	The results showed that the proliferation of H9c2 cells could be inhibited after being treated with 200 muM H2O2 for 12 h, and 100 mug/ml FGF1 could increase the proliferation rate of H9c2 cells, mitochondrial membrane potential and the mRNA expression of Bcl-2, and reduce the ROS accumulation, the level of apoptosis, the content of intracellular calcium and the mRNA expression of Bax and Caspase-3 caused by H2O2.	ros	278-281	fibroblast growth factor 1	Rattus norvegicus	138-142
18718487-2	2008	In previous studies, we demonstrated that SAA stimulated the production of TNF-alpha, IL-1beta, IL-8, NO, and ROS by neutrophils and/or mononuclear cells.	ros	110-113	serum amyloid A1 cluster	Homo sapiens	42-45
32605179-4	2020	Consistently, seedlings mutating two major ROS-generating enzyme genes, respiratory burst oxidase homologs D and F (RBOHD and RBOHF), abolished the root ROS accumulation and impaired the growth inhibition of the roots induced by Pep1.	ros	43-46	precursor of peptide 1	Arabidopsis thaliana	229-233
32605179-4	2020	Consistently, seedlings mutating two major ROS-generating enzyme genes, respiratory burst oxidase homologs D and F (RBOHD and RBOHF), abolished the root ROS accumulation and impaired the growth inhibition of the roots induced by Pep1.	ros	153-156	precursor of peptide 1	Arabidopsis thaliana	229-233
18433991-1	2008	In the present study, we demonstrated that changes in Rac1 activity associated with the production of intracellular ROS modulate the migratory properties in MCF-7 and T47D human mammary cell lines.	ros	116-119	Rac family small GTPase 1	Homo sapiens	54-58
32605179-5	2020	Furthermore, we revealed that botrytis-induced kinase 1 (BIK1) physically interacted with PEPRs and RBOHD/F, respectively, and served downstream of the Pep1-PEPRs signaling pathway to regulate Pep1-induced ROS production and root growth inhibition.	ros	206-209	precursor of peptide 1	Arabidopsis thaliana	152-156
18433991-4	2008	Our data also provides evidence that NADPH oxidase could constitute the main source of intracellular ROS in response to changes in Rac1 activity.	ros	101-104	Rac family small GTPase 1	Homo sapiens	131-135
32605179-5	2020	Furthermore, we revealed that botrytis-induced kinase 1 (BIK1) physically interacted with PEPRs and RBOHD/F, respectively, and served downstream of the Pep1-PEPRs signaling pathway to regulate Pep1-induced ROS production and root growth inhibition.	ros	206-209	precursor of peptide 1	Arabidopsis thaliana	193-197
32575075-4	2020	Here, using a high-fat diet (HFD)-induced diabetic mouse model, we showed for the first time that downregulation of active beta-catenin due to abnormal GSK3beta activation caused synaptic neurodegeneration of RGCs by inhibiting ROS scavenging enzymes, thus triggering oxidative stress-driven mitochondrial impairment in HFD-induced diabetes.	ros	228-231	catenin (cadherin associated protein), beta 1	Mus musculus	123-135
18443422-9	2008	In addition, when exposed to MV-induced oxidative stress, eight representative ROS response genes were expressed at lower levels in ugt71c1-1 plants, indicating that ugt71c1-1 probably has higher non-enzymatic antioxidant activity.	ros	79-82	UDP-glucosyl transferase 71C1	Arabidopsis thaliana	132-139
18443422-9	2008	In addition, when exposed to MV-induced oxidative stress, eight representative ROS response genes were expressed at lower levels in ugt71c1-1 plants, indicating that ugt71c1-1 probably has higher non-enzymatic antioxidant activity.	ros	79-82	UDP-glucosyl transferase 71C1	Arabidopsis thaliana	166-173
18239155-13	2008	CONCLUSIONS: PARP-1 inhibition prevents ROS- and RNS-induced HUVEC death by maintaining cellular energy in the form of NAD(+) and ATP, and also by activating a survival pathway via VEGFR2, Akt, and BAD phosphorylation.	ros	40-43	kinase insert domain receptor	Homo sapiens	181-187
32617137-8	2020	On the whole, these findings suggest that elevated ROS-mediated JNK is a key mediator in chronic ischemic conditions and has a crucial role in neuroinflammation, neurodegeneration, and memory dysfunction.	ros	51-54	mitogen-activated protein kinase 8	Mus musculus	64-67
18262205-0	2008	YS 49, 1-(alpha-naphtylmethyl)-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, regulates angiotensin II-stimulated ROS production, JNK phosphorylation and vascular smooth muscle cell proliferation via the induction of heme oxygenase-1.	ros	113-116	heme oxygenase 1	Rattus norvegicus	216-232
32209255-6	2020	Further study revealed that GDF15 knockdown promoted the decreased level of extracellular glutamate and intracellular GSH as well as the increased level of lipid ROS in the presence of erastin in MGC803 cells.	ros	162-165	growth differentiation factor 15	Homo sapiens	28-33
18262205-6	2008	Similarly, VSMC proliferation, ROS production and phosphorylation of JNK by Ang II were significantly inhibited in VSMCs transfected with the HO-1 gene.	ros	31-34	heme oxygenase 1	Rattus norvegicus	142-146
18262205-7	2008	Thus, HO-1 and the HO-1 product CO play, at least in part, a crucial role in Ang II-stimulated VSMC proliferation through the regulation of ROS production and JNK phosphorylation.	ros	140-143	heme oxygenase 1	Rattus norvegicus	6-10
18164269-1	2008	The mitochondrial form of thioredoxin, thioredoxin 2 (Txn2), plays an important role in redox control and protection against ROS-induced mitochondrial damage.	ros	125-128	thioredoxin 1	Mus musculus	26-37
32550919-0	2020	Cortistatin protects against intervertebral disc degeneration through targeting mitochondrial ROS-dependent NLRP3 inflammasome activation.	ros	94-97	cortistatin	Mus musculus	0-11
32550919-12	2020	Conclusion: This study suggests the role of CST in mitochondrial ROS and activation of the NLRP3 inflammasome in IVD degeneration, which might shed light on therapeutic targets for IVD degeneration.	ros	65-68	cortistatin	Mus musculus	44-47
18191273-6	2008	These data suggest that prevention of apoptosis conferred by ablation of p66(shc) results from changed ROS-scavenging, but not inhibition of ROS generation.	ros	103-106	src homology 2 domain-containing transforming protein C1	Mus musculus	73-76
18191273-6	2008	These data suggest that prevention of apoptosis conferred by ablation of p66(shc) results from changed ROS-scavenging, but not inhibition of ROS generation.	ros	103-106	src homology 2 domain-containing transforming protein C1	Mus musculus	77-80
32566092-13	2020	Stretching the RPV also significantly increased ROS generation after 1 hour, whereas APN significantly decreased mechanical stretch-induced ROS production.	ros	140-143	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	85-88
32268176-1	2020	NOX2 has a key role for cellular production of reactive oxidant species (ROS) and although the mechanism of its activation is well known, little is known about its regulation.	ros	73-76	cytochrome b-245 beta chain	Homo sapiens	0-4
32268176-9	2020	Treating cells with NOX2ds-tat, an inhibitor of NADPH oxidase, significantly reduced ROS formation, sNOX2-dp, MMP2 expression and MMP2-NOX2-complex, which were all restored if cells were added with H2O2.	ros	85-88	cytochrome b-245 beta chain	Homo sapiens	20-24
17996218-11	2008	The contribution of ROS to PEPCK blockage is analyzed.	ros	20-23	phosphoenolpyruvate carboxykinase 1	Rattus norvegicus	27-32
32508682-5	2020	Taken together, our results suggest that CIH promotes the production of ROS that upregulates the level of PGC-1alpha, which may in turn inhibits the transcription of BACE1, and that a reduction in the BACE1 level may be related to CIH-induced reversible and ROS-dependent carotid body plasticity.	ros	72-75	beta-secretase 1	Rattus norvegicus	166-171
32508682-5	2020	Taken together, our results suggest that CIH promotes the production of ROS that upregulates the level of PGC-1alpha, which may in turn inhibits the transcription of BACE1, and that a reduction in the BACE1 level may be related to CIH-induced reversible and ROS-dependent carotid body plasticity.	ros	258-261	beta-secretase 1	Rattus norvegicus	201-206
17980607-6	2008	Furthermore, the level of microctubule-associated-protein light chain 3 (LC3) II protein and monodancylcanaverin (MDC) incorporation were gradually increased with reduction of mitochondrial membrane potential by the accumulation of intracellular ROS after eupalinin A treatment.	ros	246-249	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	73-76
32173525-0	2020	PINK1/Parkin mediated mitophagy ameliorates palmitic acid-induced apoptosis through reducing mitochondrial ROS production in podocytes.	ros	107-110	PTEN induced kinase 1	Rattus norvegicus	0-5
17764667-5	2008	Several signalling pathways (PKC, RhoA/Rho kinase, ROS) which have been identified as prominent regulators of Ca2+ sensitivity will be discussed.	ros	51-54	carbonic anhydrase 2	Homo sapiens	110-113
32173525-7	2020	Taken together, our results suggest that PINK1/Parkin mediated mitophagy plays a protective role in PA-induced podocytes apoptosis through reducing mitochondrial ROS production and that enhancing mitophagy provides a potential therapeutic strategy for kidney diseases with hyperlipidemia, such as DN.	ros	162-165	PTEN induced kinase 1	Rattus norvegicus	41-46
32223222-5	2020	Treatment of multiple myeloma (MM) cells, a disease of plasma cells originating in the bone marrow, with 89Zr-TiO2-Tf generated cytotoxic ROS to induce cancer cell killing via apoptosis pathway.	ros	138-141	transferrin	Mus musculus	115-117
18182845-9	2007	S. pombe cells harboring plasmid pFGRX6 had elevated ROS levels whereas S. pombe cells harboring extra copies of Grx3 had reduced ROS levels.	ros	130-133	monothiol glutaredoxin GRX3	Saccharomyces cerevisiae S288C	113-117
32300208-9	2020	Pharmacological targeting of ROS- and ERK1/2 signalling pathways prevented CSE-induced senescence of CCR6+Th17 lymphocytes as well as VEGFalpha secretion.	ros	29-32	C-C motif chemokine receptor 6	Homo sapiens	101-105
18006041-0	2007	Increased ROS generation in subsets of OGG1 knockout fibroblast cells.	ros	10-13	8-oxoguanine DNA-glycosylase 1	Mus musculus	39-43
32318242-8	2020	Moreover, double deletion of ISC1 and PKH1 has a drastic effect on cell survival associated with increased ROS accumulation and release of cytochrome c, which is counteracted by overexpression of the PKA pathway negative regulator PDE2.	ros	107-110	inositol phosphosphingolipid phospholipase	Saccharomyces cerevisiae S288C	29-33
18006041-4	2007	Our data reveal that a subset of Ogg1(-/-) cells shows higher ROS levels ((H)ROS cells), while approximately 85% of Ogg1(-/-) cells exhibit physiological levels of ROS ((L)ROS cells).	ros	62-65	8-oxoguanine DNA-glycosylase 1	Mus musculus	33-37
18006041-4	2007	Our data reveal that a subset of Ogg1(-/-) cells shows higher ROS levels ((H)ROS cells), while approximately 85% of Ogg1(-/-) cells exhibit physiological levels of ROS ((L)ROS cells).	ros	77-80	8-oxoguanine DNA-glycosylase 1	Mus musculus	33-37
18006041-4	2007	Our data reveal that a subset of Ogg1(-/-) cells shows higher ROS levels ((H)ROS cells), while approximately 85% of Ogg1(-/-) cells exhibit physiological levels of ROS ((L)ROS cells).	ros	77-80	8-oxoguanine DNA-glycosylase 1	Mus musculus	33-37
18006041-4	2007	Our data reveal that a subset of Ogg1(-/-) cells shows higher ROS levels ((H)ROS cells), while approximately 85% of Ogg1(-/-) cells exhibit physiological levels of ROS ((L)ROS cells).	ros	77-80	8-oxoguanine DNA-glycosylase 1	Mus musculus	33-37
17707342-8	2007	Taken together, our observations suggest genipin signaling to apoptosis of PC3 cells is mediated via activation of ROS-dependent MLK3, which leads to downstream activation of JNK.	ros	115-118	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	129-133
32318242-8	2020	Moreover, double deletion of ISC1 and PKH1 has a drastic effect on cell survival associated with increased ROS accumulation and release of cytochrome c, which is counteracted by overexpression of the PKA pathway negative regulator PDE2.	ros	107-110	serine/threonine protein kinase PKH1	Saccharomyces cerevisiae S288C	38-42
32032646-11	2020	PON2 overexpression significantly reduced ROS, ER stress and inflammation as well as inhibited NFkappaB, and ERK1/2, phosphorylation induced by GA/CML treatment.	ros	42-45	paraoxonase 2	Homo sapiens	0-4
32146298-9	2020	Rb1 reduced LPS-associated calcium influx, ROS production, and NO generation.	ros	43-46	RB transcriptional corepressor 1	Mus musculus	0-3
17627912-4	2007	Similarly, nuclear localization of the PTH1R was observed in the cultured osteoblast-like cells MC3T3-E1, UMR106, ROS 17/2.8 and SaOS-2.	ros	114-117	parathyroid hormone 1 receptor	Sus scrofa	39-44
17532579-12	2007	We conclude that neuroglobin or cytoglobin act as ROS scavengers under ischemic conditions.	ros	50-53	neuroglobin	Homo sapiens	17-28
32256964-10	2020	In conclusion, our data demonstrated that the inhibition of EMT induced by DpdtC was realized through ferritinophagy-mediated ROS/p53 pathway, which supported that the activation of ferritinophagic flux was the main driving force in EMT inhibition in gastric cancer cells, and further strengthening the concept that NCOA4 participates in EMT process.	ros	126-129	nuclear receptor coactivator 4	Homo sapiens	316-321
17631927-6	2007	In addition, ROS scavenger pretreatment suppressed 15d-PGJ(2)-induced HO-1 expression while PPARgamma antagonist did not, suggesting nuclear translocation of Nrf-2 and subsequent HO-1 expression was ROS dependent rather than PPARgamma dependent.	ros	13-16	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	225-234
32174999-8	2020	Finally, Toll signaling activates JNK-mediated cell death through promoting ROS production.	ros	76-79	Toll	Drosophila melanogaster	9-13
32211407-5	2020	Here, we generated ROs from late-onset RP proband-derived iPSCs harboring a PDE6B mutation.	ros	19-22	phosphodiesterase 6B	Homo sapiens	76-81
17479408-8	2007	In addition, elevated intracellular levels of ROS components (O2-* and H2O2) and activation of JNK, ERK, and MAPK were found with corresponding upregulation of JWA protein expression.	ros	46-49	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	160-163
32092796-0	2020	Increased miR-34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS-JNK-p53 pathway in Alzheimer"s Disease.	ros	82-85	synaptotagmin I	Mus musculus	58-73
32092796-12	2020	These results indicated that increased miR-34c mediated synaptic and memory deficits by targeting SYT1 through ROS-JNK-p53 pathway and the miR-34c/SYT1 pathway could be considered as a promising novel therapeutic target for patients with AD.	ros	111-114	microRNA 34c	Homo sapiens	39-46
17441349-16	2007	The mechanism of the protective effect of NAC may include the deactivation of the NF-kappaB/IL-8 and the reduce of the production of ROS.	ros	133-136	NLR family, pyrin domain containing 1A	Mus musculus	42-45
31756327-9	2020	Thus, OXY initiates ROS-mediated, apoptosis-like cell death, involving mitochondrial membrane depolarization, translocation of AIF into the nucleus, and DNA fragmentation, resulting in caspase-independent cell death in MDA-MB-231 cells.	ros	20-23	apoptosis inducing factor mitochondria associated 1	Homo sapiens	127-130
17112681-1	2007	The objective of this review was to direct attention about methemoglobin as a biomarker which has an important role in the detection of adverse effects of the oxidative stress, misbalanced production of ROS, RNS and RSS.	ros	203-206	hemoglobin subunit gamma 2	Homo sapiens	59-72
32184914-8	2020	Furthermore, CIRBP overexpression prevented the elevation of ROS induced by Abeta 25-35 treatment by decreasing the activities of oxidative biomarker and increasing the activities of key enzymes in antioxidant system.	ros	61-64	cold inducible RNA binding protein	Rattus norvegicus	13-18
17010408-3	2006	One of the candidates for an ARF4 effector is the ARF-GAP ASAP1, which may function as a subunit of, or form a novel protein coat involved in trafficking from the TGN and in cytoskeletal remodeling, whose assembly is regulated by the binding of ARF4 to rhodopsin, and whose function is essential for the polarized trafficking toward the ROS.	ros	337-340	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	58-63
16987501-12	2006	These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation.	ros	73-76	dihydropyrimidinase like 3	Homo sapiens	159-165
16987501-12	2006	These results indicate that changes in Ca(2+) homeostasis resulting from ROS-dependent activation of L-VGCC are sufficient to induce probable calpain-mediated DPYSL3 truncation and demonstrate for the first time the role of ROS in the mechanism leading to glutamate-induced calpain activation and DPYSL3 protein degradation.	ros	73-76	dihydropyrimidinase like 3	Homo sapiens	297-303
16883569-8	2006	Finally, we found that direct induction of mitochondrial elongation by blocking mitochondrial fission process with Fis1-DeltaTM or Drp1-K38A was sufficient to develop senescent phenotypes with increased ROS production.	ros	203-206	fission, mitochondrial 1	Homo sapiens	115-119
16481037-5	2006	These findings indicate that adaphostin+/-bortezomib circumvent imatinib resistance due to Bcr/Abl point mutations most likely through ROS generation.	ros	135-138	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	91-98
16904205-2	2006	Growth inhibition of cancer cells is dependent on ROS and ERK1/2 induction as indicated by a significantly reduced PDTC-associated growth inhibition by the free radical scavenger N-acetyl-L-cysteine (NAC) or the MEK/ERK1/2 inhibitor (PD98059).	ros	50-53	X-linked Kx blood group	Homo sapiens	200-203
16564663-5	2006	Although the exact function of UCP3 is not yet unravelled, UCP3 is activated by lipid peroxides and suggested to export fatty acid anions and/or peroxides from the mitochondrial matrix, thereby specifically protecting fatty acids from ROS-induced oxidative damage.	ros	235-238	uncoupling protein 3	Homo sapiens	59-63
16428270-4	2006	The activities of RhoA, Rac1, and Cdc42 were correlated with changes in the endothelial cytoskeleton, adherens junctions, permeability, ROS production, VEGF levels, and activities of transcription factors hypoxia-inducible factor (HIF)-1alpha and NF-kappaB.	ros	136-139	Rac family small GTPase 1	Homo sapiens	24-28
16716901-11	2006	We conclude that ROS induce hepatocellular actin-cytoskeleton rearrangement and tight-junctional impairment by a PKC-mediated, Ca2+ -dependent mechanism, which is counteracted by PKA.	ros	17-20	protein kinase C, alpha	Rattus norvegicus	113-116
16517405-4	2006	Forced PDK1 expression in hypoxic HIF-1alpha null cells increases ATP levels, attenuates hypoxic ROS generation, and rescues these cells from hypoxia-induced apoptosis.	ros	97-100	pyruvate dehydrogenase kinase 1	Homo sapiens	7-11
16041630-1	2005	The loss of the function of the peroxisomal Mpv17-protein and associated imbalanced radical oxygen species (ROS) homeostasis leads to an early onset of focal segmental glomerulosclerosis and sensorineural deafness associated with severe degeneration of cochlear structures.	ros	108-111	MpV17 mitochondrial inner membrane protein	Mus musculus	44-49
16041630-5	2005	Since Mpv17 protein contributes to ROS homeostasis, further studies are necessary to elucidate downstream signaling molecules activated by ROS.	ros	35-38	MpV17 mitochondrial inner membrane protein	Mus musculus	6-11
16041630-5	2005	Since Mpv17 protein contributes to ROS homeostasis, further studies are necessary to elucidate downstream signaling molecules activated by ROS.	ros	139-142	MpV17 mitochondrial inner membrane protein	Mus musculus	6-11
16079144-11	2005	In parallel combined uncoupling protein depletion and isolated uncoupling protein-2 depletion augments ROS production in viable cardiomyocytes following anoxia-reoxygenation.	ros	103-106	uncoupling protein 2	Rattus norvegicus	63-83
16295780-1	2005	BACKGROUND: The purpose of this study was to determine the adequate loading and maintenance doses of N-acetylcyseteine (NAC) for patients suffering from acute ROS-induced injury.	ros	159-162	X-linked Kx blood group	Homo sapiens	101-124
16295780-4	2005	RESULTS: In vivo, NAC suppressed ROS in a dose dependant manner.	ros	33-36	X-linked Kx blood group	Homo sapiens	18-21
16295780-5	2005	10 mM of NAC suppressed about 50% of ROS, and was comparable to 10 microM of Cys and Met and 400 microM of Cys2.	ros	37-40	X-linked Kx blood group	Homo sapiens	9-12
16295780-8	2005	The loading and maintenance NAC doses used to reach the target concentration of 10 mM, were 5010 mg. kg(-1) and 2250 mg min(-1) kg(-1), respectively CONCLUSION: NAC provides an antioxidant effect on ROS produced by paraquat in vivo.	ros	199-202	X-linked Kx blood group	Homo sapiens	161-164
16036323-8	2005	Thus, vascular patency is correlated with eNOS-Ser1177 phosphorylation in association with ROS, and PKC during reperfusion.	ros	91-94	nitric oxide synthase 3	Rattus norvegicus	42-46
15820617-9	2005	We conclude that in elderly patients the gastric mRNA expression of the ROS-generating enzyme NOX2 increases as a function of age, possibly contributing to stomach aging and gastric vulnerability of the elderly.	ros	72-75	cytochrome b-245 beta chain	Homo sapiens	94-98
15780950-0	2005	Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells.	ros	117-120	FKBP prolyl isomerase 1A	Rattus norvegicus	30-54
15780950-0	2005	Characterisation of cytosolic FK506 binding protein 12 and its role in modulating expression of Cbfa1 and osterix in ROS 17/2.8 cells.	ros	117-120	Sp7 transcription factor	Rattus norvegicus	106-113
15556616-0	2004	S100B-modulated Ca2+-dependent ROS-GC1 transduction machinery in the gustatory epithelium: a new mechanism in gustatory transduction.	ros	31-34	S100 calcium binding protein B	Bos taurus	0-5
15556616-5	2004	S100B senses increments in free Ca2+, undergoes conformational change, binds to the domain amino acids (aa) Gly962-Asn981 and via the transduction domain aa Ile1030-Gln1041 activates ROS-GC1, generating the second messenger, cyclic GMP.	ros	183-186	S100 calcium binding protein B	Bos taurus	0-5
15183009-7	2004	CATH.a cells were significantly protected by the addition of 5mM GSH (Mn EC50 = 200 microM) and 10mM N-acetyl cysteine (NAC) (Mn EC50 = 300 microM), therefore, indirectly identifying intracellular ROS formation as a mechanism for Mn neurotoxicity.	ros	197-200	cathepsin H	Mus musculus	0-4
32096759-5	2020	Moreover, independent of this activity, Trx1 is critical for NLRP3 inflammasome activation and IL-1b production in macrophages by detoxifying excessive ROS levels.	ros	152-155	thioredoxin 1	Mus musculus	40-44
31672277-9	2020	Cysteine and glutamine supplementation restored GSH and prevented ROS-induced cell death of LAMP2-KD RPE cells.	ros	66-69	lysosomal associated membrane protein 2	Homo sapiens	92-97
31407062-0	2020	Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats.	ros	29-32	cytochrome b-245 beta chain	Rattus norvegicus	0-4
31407062-0	2020	Nox2 and Nox4 Participate in ROS-Induced Neuronal Apoptosis and Brain Injury During Ischemia-Reperfusion in Rats.	ros	29-32	NADPH oxidase 4	Rattus norvegicus	9-13
30513217-6	2019	Knockdown of GINS2 significantly increased alcohol-induced ROS production and the oxidative stress marker malondialdehyde.	ros	59-62	GINS complex subunit 2 (Psf2 homolog)	Mus musculus	13-18
31511637-0	2019	Correction to: The IRAK-ERK-p67phox-Nox-2 axis mediates TLR4, 2-induced ROS production for IL-1beta transcription and processing in monocytes.	ros	72-75	cytochrome b-245 beta chain	Homo sapiens	36-41
31300985-1	2019	PURPOSE: Early activation of cytosolic NADPH oxidase-2 (Nox2) in diabetes increases retinal ROS production, damaging their mitochondria.	ros	92-95	cytochrome b-245 beta chain	Homo sapiens	39-54
31300985-1	2019	PURPOSE: Early activation of cytosolic NADPH oxidase-2 (Nox2) in diabetes increases retinal ROS production, damaging their mitochondria.	ros	92-95	cytochrome b-245 beta chain	Homo sapiens	56-60
31539718-8	2019	The underlying mechanism was related to the activation of the Nrf2/Ho-1 signaling pathway, which subsequently suppressed intracellular reactive oxidative species (ROS) production and malondialdehyde (MDA) and NADPH oxidase (Nox) activity, and to the restoration of Sod and Gsh-px activation.	ros	163-166	heme oxygenase 1	Rattus norvegicus	67-71
31520993-12	2019	miR-206 can target the 3"-UTR of SOD1 to inhibit SOD1 expression, which leads to the increase of ROS level and aggravates pulmonary inflammatory response and asthma symptoms in asthmatic mice.	ros	97-100	microRNA 206	Mus musculus	0-7
31351395-5	2019	Finally, taking into account that hypoxia-induced ROS accumulation also increases expression and activity of 5-lipoxygenase (5-LOX) with production of leukotrienes, we have disclosed structural key factors crucial for 5-LOX activity.	ros	50-53	lysyl oxidase	Rattus norvegicus	127-130
31451038-9	2019	These Rac1 dependent activities were characterized by NOX2-mediated ROS production.	ros	68-71	Rac family small GTPase 1	Homo sapiens	6-10
31451038-9	2019	These Rac1 dependent activities were characterized by NOX2-mediated ROS production.	ros	68-71	cytochrome b-245 beta chain	Homo sapiens	54-58
31451038-11	2019	This was likely due to the ability of statins to block Rac1 prenylation as geranylgeranyl transferase inhibitors were effective in inhibiting HIV-Nef-induced ROS formation.	ros	158-161	Rac family small GTPase 1	Homo sapiens	55-59
31601785-6	2019	Taken together, this study for the first time found that the effect of 1, 4-BQ on the crosstalk between autophagy and apoptosis were modulated by the ROS generation via enhancing phosphorylation of Bcl-2(Ser70) and phosphorylation of beclin1(Thr119), which offered a novel insight into underlying molecular mechanisms of benzene-induced hematotoxicity, and specifically how the crosstalk between autophagy and apoptosis was involved in benzene toxicity.	ros	150-153	beclin 1	Homo sapiens	234-241
31523955-0	2019	Ochratoxin A triggered chicken heterophil extracellular traps release through ROS production dependent on activation of NADPH oxidase, ERK and p38 MAPK signaling pathways.	ros	78-81	adapter molecule crk	Gallus gallus	143-146
31523955-11	2019	Above results suggest that OTA-induced HETs formation is related to ROS production dependent on the activation of NADPH oxidase, ERK and p38 MAPK signaling pathways.	ros	68-71	adapter molecule crk	Gallus gallus	137-140
31390228-0	2019	Angiotensin II deteriorates advanced atherosclerosis by promoting MerTK cleavage and impairing efferocytosis through AT1R/ROS/p38MAPK/ADAM17 pathway.	ros	122-125	ADAM metallopeptidase domain 17	Homo sapiens	134-140
31390228-5	2019	Ang II-activated ADAM17 required ROS and p38 MAPK phosphorylation.	ros	33-36	ADAM metallopeptidase domain 17	Homo sapiens	17-23
31390228-6	2019	Selective angiotensin II type 1 receptor (AT1R) blocker losartan suppressed ROS production and ROS scavenger N-Acetyl-L-cysteine (NAC) prevented p38 MAPK phosphorylation.	ros	95-98	X-linked Kx blood group	Homo sapiens	130-133
31065944-3	2019	We discuss the agonistic effect on the Sirtuin1-PGC-1alpha-PPAR pathway as well as Sirtuin 3, which converge in improving mitochondrial function, decreasing ROS production and ameliorating bioenergetics deficits.	ros	157-160	sirtuin 1	Homo sapiens	39-47
15327746-8	2004	The observed inhibition of mdr genes was attenuated by all co-treatments, suggesting that retinol-induced ROS are required for inhibition of mdr1 and mdr3 expression.	ros	106-109	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	141-145
31271840-4	2019	Moreover, significantly higher intracellular ROS levels were detected in mIgM+ B lymphocytes following rIL-10 stimulation.	ros	45-48	immunoglobulin heavy constant mu	Mus musculus	73-77
31271840-6	2019	In addition, we also found that the enhancing effect of IL-10 on phagocytosis and intracellular ROS levels of mIgM+ B lymphocytes were suppressed by the administration of niclosamide.	ros	96-99	immunoglobulin heavy constant mu	Mus musculus	110-114
31385138-5	2019	Therefore, we hypothesized that Apelin-13 might adequately prevent METH-induced neurotoxicity via the inhibition of apoptotic, autophagy, and ROS responses.	ros	142-145	apelin	Rattus norvegicus	32-38
14581623-0	2003	Arabidopsis NDK1 is a component of ROS signaling by interacting with three catalases.	ros	35-38	nucleoside diphosphate kinase	Arabidopsis thaliana	12-16
14581623-15	2003	These results indicate that AtNDK1 has a role in ROS response.	ros	49-52	nucleoside diphosphate kinase	Arabidopsis thaliana	28-34
31385138-9	2019	In addition, this study has shown that Apelin-13 reduces intracellular ROS of METH-induced PC12 cells.	ros	71-74	apelin	Rattus norvegicus	39-45
31507536-5	2019	In vitro studies using vascular smooth muscle cells found that pre-treatment with the GPER agonist G-1 inhibited Ang II-induced ROS and NADP/NADPH.	ros	128-131	G protein-coupled estrogen receptor 1	Mus musculus	86-90
31507536-8	2019	We conclude that during conditions of elevated Ang II, GPER via the cAMP pathway suppresses Nox4 transcription to limit ROS production and prevent arterial stiffening.	ros	120-123	G protein-coupled estrogen receptor 1	Mus musculus	55-59
11911960-0	2002	1,25-Dihydroxyvitamin D3 selectively translocates PKCalpha to nuclei in ROS 17/2.8 cells.	ros	72-75	protein kinase C, alpha	Rattus norvegicus	50-58
31085189-0	2019	Guanine-rich RNA binding protein GRSF1 inhibits myoblast differentiation through repressing mitochondrial ROS production.	ros	106-109	G-rich RNA sequence binding factor 1	Mus musculus	33-38
11911960-1	2002	We have investigated protein kinase C (PKC) regulation by 1,25-(OH)2D3 in the rat osteosarcoma cell line ROS 17/2.8 since previous reports have implicated PKC in the 1,25-(OH)2D3-mediated regulation of osteocalcin gene expression (J. Biol.	ros	105-108	protein kinase C, alpha	Rattus norvegicus	39-42
31085189-6	2019	Further studies illustrated that GRSF1 regulated myogenic differentiation through direct targeting of mitochondrial GPX4, a key regulator of the cellular redox status, leading to the modulation of ROS levels, which is important for myogenesis.	ros	197-200	G-rich RNA sequence binding factor 1	Mus musculus	33-38
11704501-5	2001	5-HTT binding sites were assessed in ROS 17/2.8 and UMR 106-H5 cells by binding of the stable cocaine analog [125I]RTI-55, which showed a relatively high density of nanomolar affinity binding sites.	ros	37-40	huntingtin	Rattus norvegicus	2-5
31153046-11	2019	The results of this study suggested a protective role of CORM-2 in PM-induced lung inflammation by inhibiting the TLR2 and TLR4/ROS-NLRP3 inflammasome-CRP axial.	ros	128-131	C-reactive protein, pentraxin-related	Mus musculus	151-154
31085231-6	2019	Bleomycin treatment resulted in decreases in protein expressions of Sirtuin 3 (SIRT3) in the lung, which were restored by ROS scavenger NAC and probucol treatment, suggesting that probucol might restore SIRT3 expression by suppressing bleomycin-induced oxidative stress.	ros	122-125	NLR family, pyrin domain containing 1A	Mus musculus	136-139
31171361-0	2019	miR-374a/Myc axis modulates iron overload-induced production of ROS and the activation of hepatic stellate cells via TGF-beta1 and IL-6.	ros	64-67	microRNA 374a	Homo sapiens	0-8
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	276-279	microRNA 374a	Homo sapiens	0-8
10773581-0	2000	Endogenous parathyroid hormone-related peptide enhances proliferation and inhibits differentiation in the osteoblast-like cell line ROS 17/2.8.	ros	132-135	parathyroid hormone-like hormone	Rattus norvegicus	11-46
31171361-4	2019	miR-374a could target Myc, a co-transcription factor of both TGF-beta1 and IL-6, to negatively regulate Myc expression; FAC stimulation significantly suppressed miR-374a expression, whereas the suppressive effect of FAC stimulation on miR-374a expression could be reversed by ROS inhibitor NAC, indicating that miR-374a could be modulated by iron overload-induced ROS.	ros	364-367	microRNA 374a	Homo sapiens	0-8
31171361-7	2019	In conclusion, we demonstrate a novel mechanism of miR-374a/Myc axis modulating iron overload-induced production of ROS and the activation of HSCs via TGF-beta1 and IL-6.	ros	116-119	microRNA 374a	Homo sapiens	51-59
31241045-8	2019	In conclusion, GLP-1 analogue liraglutide decreased activity of caspases 3/7, reduced ROS production and didn"t exhibit negative effects on cell viability and oxidative stress in primary cultures of hepatocytes isolated from lean and steatotic livers.	ros	86-89	glucagon	Rattus norvegicus	15-20
10731641-5	2000	The induction of mRNA for ckb in ROS 17/2.8 cells by E(2) or SERMS was demonstrated only after vitamin D pretreatment; there was no inhibition of E(2) induction by SERMS.	ros	33-36	creatine kinase B	Rattus norvegicus	26-29
10430646-8	1999	In vitro, ROS 17/2.8 cells expressed detectable levels of c-fos, c-jun, c-myc, OC, OP, ALP, COL1A1, and PTHR but not MMP-9.	ros	10-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-63
10430646-8	1999	In vitro, ROS 17/2.8 cells expressed detectable levels of c-fos, c-jun, c-myc, OC, OP, ALP, COL1A1, and PTHR but not MMP-9.	ros	10-13	parathyroid hormone 1 receptor	Rattus norvegicus	104-108
10052930-6	1999	However, when stripped ROS membranes were reconstituted with both GCAP1 and either transducin (T alpha beta gamma) or the T beta gamma-subunits, the inhibition of ROS-GC by light was restored.	ros	23-26	guanylate cyclase activator 1A	Bos taurus	66-71
30963327-8	2019	The results indicate that Jac1p and Isu1p over-expression in the S. cerevisiae UMArn3.3 yeast increased its ethanol tolerance level and ethanol production by a mechanism that involves ROS and iron homeostasis related to the biogenesis/recycling of Fe-S clusters dependent proteins.	ros	184-187	J-type chaperone JAC1	Saccharomyces cerevisiae S288C	26-31
30963327-8	2019	The results indicate that Jac1p and Isu1p over-expression in the S. cerevisiae UMArn3.3 yeast increased its ethanol tolerance level and ethanol production by a mechanism that involves ROS and iron homeostasis related to the biogenesis/recycling of Fe-S clusters dependent proteins.	ros	184-187	iron-binding protein ISU1	Saccharomyces cerevisiae S288C	36-41
31217433-7	2019	Treatment with 5-FU led to JNK activation through ROS production in MDSC.	ros	50-53	mitogen-activated protein kinase 8	Mus musculus	27-30
31209224-10	2019	The effects of GsdmD protection are likely injury specific and may also depend on injury severity and levels of ROS produced.	ros	112-115	gasdermin D	Mus musculus	15-20
9788898-5	1998	ROS/RNS appear to play a variety of roles that lead to changes in expression of genes such as interleukin-6 and intercellular adhesion molecule 1.	ros	0-3	intercellular adhesion molecule 1	Homo sapiens	112-145
31209224-11	2019	These data suggest modulation of GsdmD/caspase-8 may be a novel therapeutic option in ROS-mediated liver injury.	ros	86-89	gasdermin D	Mus musculus	33-38
30853394-4	2019	We incorporate the inhibition of ORAI1 channels by ROS into our model and calculate its contribution to the CRAC channel amplitude.	ros	51-54	ORAI calcium release-activated calcium modulator 1	Homo sapiens	33-38
9860171-3	1998	In the present investigation the ability of rat osteosarcoma (ROS) cells to express TF activity was examined following their growth on tissue-culture polystyrene (TCPS) and selected orthopedic biomaterials (titanium and zirconium alloys, and stainless steel).	ros	62-65	coagulation factor III, tissue factor	Rattus norvegicus	84-86
31245366-7	2019	Likewise, PLAA NPs induced a higher dose-dependent ROS production.	ros	51-54	phospholipase A2 activating protein	Homo sapiens	10-14
9860171-4	1998	ROS cells exhibited significant TF activity as evidenced by the conversion of Factor X to Factor Xa in the presence of TF, Factor VIIa, and Ca2+.	ros	0-3	coagulation factor III, tissue factor	Rattus norvegicus	32-34
9860171-4	1998	ROS cells exhibited significant TF activity as evidenced by the conversion of Factor X to Factor Xa in the presence of TF, Factor VIIa, and Ca2+.	ros	0-3	coagulation factor III, tissue factor	Rattus norvegicus	119-121
31281569-12	2019	An in vitro study showed that pretreatment with SS31 or Drp1 inhibitor Mdivi1 could restore the level of mitochondrial ROS, the membrane potential levels, and the expressions of Drp1, Bax, Caspase1, IL-1beta, and FN in HK-2 cells under high-glucose conditions.	ros	119-122	collapsin response mediator protein 1	Mus musculus	56-60
9197412-7	1997	Although binding of MucR to this site exhibited a moderate dissociation constant of Kd approximately 1.4 x 10(-7) M, the reaction was highly specific since fragments containing binding sites for the homologous Ros protein from Agrobacterium tumefaciens were not able to compete for MucR binding.	ros	210-213	putative transcription regulator protein	Sinorhizobium meliloti	20-24
30511378-14	2019	Removal of Gremlin1 protein from GFCM eliminated the inhibitory effect of GFCM on ALP activity in ROS cells.	ros	98-101	gremlin 1, DAN family BMP antagonist	Rattus norvegicus	11-19
9151687-3	1997	We have found that ROS 17/2.8 osteosarcoma cells, UMR 106-01 osteosarcoma cells, and primary rat calvarial osteoblastic cells also express another gap junction protein, Cx46.	ros	19-22	gap junction protein, alpha 3	Rattus norvegicus	169-173
30511378-14	2019	Removal of Gremlin1 protein from GFCM eliminated the inhibitory effect of GFCM on ALP activity in ROS cells.	ros	98-101	PDZ and LIM domain 3	Rattus norvegicus	82-85
31214277-8	2019	Pretreatment with Nec-1 and GSK"872, two inhibitors of necroptosis, significantly reduced the liver IRI and ROS production in HFD-fed mice.	ros	108-111	proprotein convertase subtilisin/kexin type 1	Mus musculus	18-23
31068208-0	2019	Anti-EMT properties of CoQ0 attributed to PI3K/AKT/NFKB/MMP-9 signaling pathway through ROS-mediated apoptosis.	ros	88-91	matrix metallopeptidase 9	Homo sapiens	56-61
31130857-2	2019	In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two molecules are oppositely located in renal fibrosis.	ros	23-26	NADPH oxidase 4	Rattus norvegicus	18-22
31130857-2	2019	In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two molecules are oppositely located in renal fibrosis.	ros	23-26	ras homolog family member A	Rattus norvegicus	54-58
31130857-2	2019	In lung fibrosis, NOX4/ROS is located upstream of the RhoA/ROCK1 signaling pathway, and the two molecules are oppositely located in renal fibrosis.	ros	23-26	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	59-64
31130857-12	2019	The NOX4/ROS pathway was upstream of and positively regulated the RhoA/ROCK1 pathway in HSCs.	ros	9-12	NADPH oxidase 4	Rattus norvegicus	4-8
31130857-12	2019	The NOX4/ROS pathway was upstream of and positively regulated the RhoA/ROCK1 pathway in HSCs.	ros	9-12	ras homolog family member A	Rattus norvegicus	66-70
31130857-12	2019	The NOX4/ROS pathway was upstream of and positively regulated the RhoA/ROCK1 pathway in HSCs.	ros	9-12	Rho-associated coiled-coil containing protein kinase 1	Rattus norvegicus	71-76
31130857-14	2019	Conclusion: The NOX4/ROS and RhoA/ROCK1 signaling pathways are two critical signaling pathways in a series of behavioral processes in HSCs, and NOX4/ROS regulates RhoA/ROCK1 through an indirect pathway to control the activation of HSCs.	ros	21-24	NADPH oxidase 4	Rattus norvegicus	16-20
30761680-7	2019	Apart from the augmented IL-6 and TNF-alpha secretion, the level of ROS was upregulated and the activity of anti-oxidative SOD was reduced in cells exposed to AIF-1.	ros	68-71	allograft inflammatory factor 1	Mus musculus	159-164
30849338-5	2019	This findings were implicit the transduction of p-ERK in IS-induced ROS toxicity.	ros	68-71	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	48-53
30933478-0	2019	ROS-Responsive Polymeric Micelles for Triggered Simultaneous Delivery of PLK1 Inhibitor/miR-34a and Effective Synergistic Therapy in Pancreatic Cancer.	ros	0-3	polo like kinase 1	Homo sapiens	73-77
31014355-10	2019	Interestingly, ROS levels, which are directly regulated by AIF, show a significant reduction in SNHG15-depleted cells.	ros	15-18	apoptosis inducing factor mitochondria associated 1	Homo sapiens	59-62
31014355-10	2019	Interestingly, ROS levels, which are directly regulated by AIF, show a significant reduction in SNHG15-depleted cells.	ros	15-18	small nucleolar RNA host gene 15	Homo sapiens	96-102
31178664-7	2019	Notably, NAC, a ROS scavenger, could attenuate high glucose-induced ROS formation and IL-18 and IL-1beta mRNA and protein expression and block inflammasome activation.	ros	16-19	interleukin 18	Homo sapiens	86-91
31178965-10	2019	Based on these data, we conclude that LPS impairs StAR expression via the ROS-induced downregulation of GATA4 and GATA6.	ros	74-77	GATA binding protein 4	Homo sapiens	104-109
31178951-10	2019	To further reveal the relevant mechanism, the oxidative stress-mediated PI3K/AKT/mTOR pathway was assessed, which showed that a reduced expression of p-PI3K, p-AKT, and p-mTOR in C2C12 myoblast atrophy induced by TNF-alpha could be upregulated by ATL-III; however, after the overexpression of Nox2 to increase ROS production, the attenuated effect was reversed.	ros	310-313	mechanistic target of rapamycin kinase	Rattus norvegicus	81-85
30833080-12	2019	In conclusion, these results suggest that overexpression of HO-1 by high dose of hemin and CoPPIX can induce cell toxicity in H9c2 cells via enhanced ROS level and impaired autophagy.	ros	150-153	heme oxygenase 1	Rattus norvegicus	60-64
31015768-16	2019	Moreover, a dose dependent intracellular ROS generation of PION@E6 was detected.	ros	41-44	gamma-secretase activating protein	Homo sapiens	59-66
31015768-17	2019	Conclusion: Invasiveness of human GBM cells involves the PION@E6-mediated autophagy process, which may be related to the intracellular ROS induced by PION@E6.	ros	135-138	gamma-secretase activating protein	Homo sapiens	57-64
31015768-17	2019	Conclusion: Invasiveness of human GBM cells involves the PION@E6-mediated autophagy process, which may be related to the intracellular ROS induced by PION@E6.	ros	135-138	gamma-secretase activating protein	Homo sapiens	150-157
30659826-9	2019	Based on the observations, we conclude that MLB is able to prevent phenotypic transformation of pulmonary arteries in hypoxic PAH rats through suppression of NOX/ROS/ERK pathway, and MLB might have the potentials in PAH therapy.	ros	162-165	NADPH oxidase 4	Rattus norvegicus	158-161
30941199-6	2019	The 25 mmol/L glucose-induced SOD reduction increased MDA and intracellular ROS.	ros	76-79	superoxide dismutase 2	Rattus norvegicus	30-33
30290714-8	2019	In vitro experiments showed PRKN overexpression was sufficient to induce mitophagy during CSE exposure even in the setting of reduced PINK1 protein levels, resulting in attenuation of mitochondrial ROS production and cellular senescence.	ros	198-201	parkin RBR E3 ubiquitin protein ligase	Mus musculus	28-32
30813500-0	2019	Duck Plague Virus Promotes DEF Cell Apoptosis by Activating Caspases, Increasing Intracellular ROS Levels and Inducing Cell Cycle S-Phase Arrest.	ros	95-98	UTP25 small subunit processome component	Homo sapiens	27-30
30391442-0	2019	MiR-375 induces ROS and apoptosis in ST cells by targeting the HIGD1A gene.	ros	16-19	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	63-69
30391442-1	2019	HIGD1A can reduce ROS and apoptosis in cells under low-glucose or hypoxic conditions, and HIGD1A is one of the target genes for miR-375, according to our previous studies.	ros	18-21	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	0-6
30391442-4	2019	The results showed that ROS levels and expression levels of CASPASE3 in HIGD1A-overexpressing cells were significantly lower than those in the control cells.	ros	24-27	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	72-78
30391442-7	2019	Considering that the HIGD1A gene is a target of miR-375, these findings suggest that miR-375 can induce an increase in ROS levels and apoptosis by inhibiting HIGD1A in porcine ST cells.	ros	119-122	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	21-27
30391442-7	2019	Considering that the HIGD1A gene is a target of miR-375, these findings suggest that miR-375 can induce an increase in ROS levels and apoptosis by inhibiting HIGD1A in porcine ST cells.	ros	119-122	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	158-164
30741995-7	2019	In general, the DNA damage and ROS levels of the PRMT1-KD SK-N-SH cells were slightly increased.	ros	31-34	protein arginine methyltransferase 1	Homo sapiens	49-54
8756533-2	1996	This study demonstrates that expression of the PTHrP gene has features of early response genes, including up-regulation after serum repletion of serum-starved ROS 17/2.8 (rat osteosarcoma) cells.	ros	159-162	parathyroid hormone-like hormone	Rattus norvegicus	47-52
8756533-6	1996	Deletions of the 5" flanking sequence of the rat PTHrP gene fused to the chloramphenicol acetyltransferase gene and transfected into ROS 17/2.8 cells showed that the serum-responsive region is located between -1.05 kb and -0.3 kb upstream of the transcription start site.	ros	133-136	parathyroid hormone-like hormone	Rattus norvegicus	49-54
30726742-7	2019	beta2-integrin expression on macrophages is mechanistically linked to Rac1/ROS-mediated induction of noncanonical-NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome-dependent IL-1beta production, which promotes ILC3-derived IL-22.	ros	75-78	hemoglobin, beta adult minor chain	Mus musculus	0-5
30816885-2	2019	A critical limitation of conventional ALK/ROS TKIs is their association with acquired resistance mutations (particularly ALK G1202R and ROS1 G2032R) in the ALK or ROS1 gene, although these are not the only resistance mechanisms.	ros	42-45	ALK receptor tyrosine kinase	Homo sapiens	121-124
8886593-5	1996	PTHrP production was measured by N-terminal radioimmunoassay and bioassay (increased cAMP levels in ROS 17/2.8 osteoblast-like cells).	ros	100-103	parathyroid hormone-like hormone	Rattus norvegicus	0-5
8725179-6	1996	Nucleotide sequence of PCR fragments from ROS 17/2.8 cells revealed 100% identity with rat brain beta ARK1 and beta-arrestin 1 sequences.	ros	42-45	arrestin, beta 1	Rattus norvegicus	111-126
30816885-2	2019	A critical limitation of conventional ALK/ROS TKIs is their association with acquired resistance mutations (particularly ALK G1202R and ROS1 G2032R) in the ALK or ROS1 gene, although these are not the only resistance mechanisms.	ros	42-45	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	136-140
30816885-2	2019	A critical limitation of conventional ALK/ROS TKIs is their association with acquired resistance mutations (particularly ALK G1202R and ROS1 G2032R) in the ALK or ROS1 gene, although these are not the only resistance mechanisms.	ros	42-45	ALK receptor tyrosine kinase	Homo sapiens	121-124
30816885-2	2019	A critical limitation of conventional ALK/ROS TKIs is their association with acquired resistance mutations (particularly ALK G1202R and ROS1 G2032R) in the ALK or ROS1 gene, although these are not the only resistance mechanisms.	ros	42-45	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	163-167
8845513-9	1996	Recently, however, one antibody was used to clone the cDNA for the beta-galactoside-binding lectin, galectin 3 or epsilon binding protein (epsilon BP; IgE-binding protein; Mac-2), from a lambda gt11 osteoblast expression library; another was used to clone from an ROS 17/2.8-COS cell expression library the cDNA for OTS-8, a putative target gene of early response genes stimulated in response to phorbol esters in MC3T3-E1 cells.	ros	264-267	lectin, galactoside-binding, soluble, 3 binding protein	Mus musculus	100-137
30456799-10	2019	Gene expression of the NADPH oxidase subunits NOX2 and NOX4, which participate in ROS generation, did not differ between groups.	ros	82-85	cytochrome b-245 beta chain	Rattus norvegicus	46-50
7756693-13	1995	MucR contains like Ros a putative zinc finger sequence of the C2H2 type.	ros	19-22	putative transcription regulator protein	Sinorhizobium meliloti	0-4
9397968-4	1994	PTH-stimulated cAMP levels were significantly increased in ROS 17/2.8 cells treated with TGF-beta1 (0.5 ng/ml) for 48 h. These data indicate that TGF-beta1 upregulates steady-state mRNA, ligand binding and PTH/PTHrP receptor signaling in rat osteosarcoma cells.	ros	59-62	parathyroid hormone-like hormone	Rattus norvegicus	210-215
8125125-4	1994	In addition, the production of reactive oxygen radical species (ROS) of eosinophils after C3a and C5a stimulation was measured by lucigenin-dependent chemiluminescence and quantified by superoxide dismutase-inhibitable reduction of ferricytochrome C. Half maximal and maximal ROS production in response to C3a was observed at 50 ng/ml and 1000 ng/ml, respectively, whereas C3a-desArg was inactive.	ros	64-67	complement C3	Homo sapiens	90-93
8125125-4	1994	In addition, the production of reactive oxygen radical species (ROS) of eosinophils after C3a and C5a stimulation was measured by lucigenin-dependent chemiluminescence and quantified by superoxide dismutase-inhibitable reduction of ferricytochrome C. Half maximal and maximal ROS production in response to C3a was observed at 50 ng/ml and 1000 ng/ml, respectively, whereas C3a-desArg was inactive.	ros	64-67	complement C3	Homo sapiens	306-309
8125125-4	1994	In addition, the production of reactive oxygen radical species (ROS) of eosinophils after C3a and C5a stimulation was measured by lucigenin-dependent chemiluminescence and quantified by superoxide dismutase-inhibitable reduction of ferricytochrome C. Half maximal and maximal ROS production in response to C3a was observed at 50 ng/ml and 1000 ng/ml, respectively, whereas C3a-desArg was inactive.	ros	64-67	complement C3	Homo sapiens	306-309
8125125-4	1994	In addition, the production of reactive oxygen radical species (ROS) of eosinophils after C3a and C5a stimulation was measured by lucigenin-dependent chemiluminescence and quantified by superoxide dismutase-inhibitable reduction of ferricytochrome C. Half maximal and maximal ROS production in response to C3a was observed at 50 ng/ml and 1000 ng/ml, respectively, whereas C3a-desArg was inactive.	ros	276-279	complement C3	Homo sapiens	90-93
8125125-10	1994	Furthermore, the C3a- and C5a-induced production of ROS of eosinophils was totally inhibited by pertussis toxin, indicating the involvement of guanine nucleotide-binding proteins (Gi-proteins).	ros	52-55	complement C3	Homo sapiens	17-20
7857077-3	1994	cDNA clones of PTH/PTHrP receptors from rat osteosarcoma (ROS 17/2.8) and opossum kidney (OK) cells are highly homologous and are members of a novel G protein-linked receptor family that includes calcitonin, glucagon, GLP-1, GHRH, VIP, and secretin receptors.	ros	58-61	parathyroid hormone-like hormone	Rattus norvegicus	19-24
8274878-7	1993	Our results suggest that the effects of dexamethasone, 1,25(OH)2D3 and PKC on PTH-sensitive adenylate cyclase in ROS 17/2.8 cells are independent of each other.	ros	113-116	protein kinase C, gamma	Rattus norvegicus	71-74
8319205-6	1993	The PTHrP mRNA transcripts were translated into immunoreactive hPTHrP as measured by radioimmunoassay, and conditioned medium from transfected cell lines stimulated cyclic AMP (cAMP) formation in ROS 17/2.8 osteosarcoma cells.	ros	196-199	parathyroid hormone-like hormone	Rattus norvegicus	4-9
8430499-7	1993	Anti-PTHrP IgG inhibited the in vitro biologic activity of PTHrP as demonstrated by the inhibition of adenylate cyclase stimulation in a rat osteoblast-like cell line (ROS 17/2.8).	ros	168-171	parathyroid hormone-like hormone	Rattus norvegicus	5-10
8430499-7	1993	Anti-PTHrP IgG inhibited the in vitro biologic activity of PTHrP as demonstrated by the inhibition of adenylate cyclase stimulation in a rat osteoblast-like cell line (ROS 17/2.8).	ros	168-171	parathyroid hormone-like hormone	Rattus norvegicus	59-64
1412468-5	1992	Following treatment of ROS cells with Pb2+, intracellular levels of the calcium-binding protein osteonectin/SPARC were increased.	ros	23-26	secreted protein acidic and cysteine rich	Rattus norvegicus	96-107
1412468-5	1992	Following treatment of ROS cells with Pb2+, intracellular levels of the calcium-binding protein osteonectin/SPARC were increased.	ros	23-26	secreted protein acidic and cysteine rich	Rattus norvegicus	108-113
1309253-1	1992	The human insulinlike growth factor 1 (hIGF-1) receptor (hIGFR) is a transmembrane protein tyrosine kinase (PTK) molecule which shares high sequence homology in the PTK domain with the insulin receptor and, to a lesser degree, the ros transforming protein of avian sarcoma virus UR2.	ros	93-96	insulin like growth factor 1 receptor	Homo sapiens	57-62
1309253-3	1992	The full-length hIGFR cDNA (fIGFR) was cloned into a UR2 retroviral vector, replacing the original oncogene v-ros.	ros	110-113	insulin like growth factor 1 receptor	Homo sapiens	16-21
2173777-0	1990	Role of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion protein.	ros	120-123	uncharacterized LOC107052719	Gallus gallus	8-11
2173777-0	1990	Role of gag sequence in the biochemical properties and transforming activity of the avian sarcoma virus UR2-encoded gag-ros fusion protein.	ros	120-123	uncharacterized LOC107052719	Gallus gallus	116-119
2173777-1	1990	The transforming protein P68gag-ros of avian sarcoma virus UR2 is a transmembrane tyrosine protein kinase molecule with the gag portion protruding extracellularly.	ros	32-35	uncharacterized LOC107052719	Gallus gallus	28-31
2163325-5	1990	[Asn10Leu11]- and [Asn10,leu11,D-Trp12]-PTHrP(7-34)NH2 were found to be 23- and 26-fold more potent as antagonists in ROS cells than PTHrP(7-34)NH2 and [D-Trp12]PTHrP(7-34)NH2, respectively.	ros	118-121	parathyroid hormone-like hormone	Rattus norvegicus	40-45
2154457-0	1990	Evidence for insulin-dependent activation of S6 and microtubule-associated protein-2 kinases via a human insulin receptor/v-ros hybrid.	ros	124-127	microtubule associated protein 2	Homo sapiens	52-84
33820875-9	2021	This study found that overexpression of hepcidin significantly inhibited ROS production, mitochondrial biogenesis, and PGC-1beta expression.	ros	73-76	hepcidin antimicrobial peptide	Mus musculus	40-48
33820875-10	2021	These data showed that hepcidin protected osteoporosis by reducing iron levels in bone tissue, and in conjunction with PGC-1beta, reduced ROS production and the number of mitochondria, thus inhibiting osteoclast differentiation and bone absorption.	ros	138-141	hepcidin antimicrobial peptide	Mus musculus	23-31
24801072-7	2015	Indeed, gene silencing of Pin1 in HAECs suppressed p66(Shc)-dependent ROS production, restored NO release and blunted NF-kB p65 nuclear translocation.	ros	70-73	SHC adaptor protein 1	Homo sapiens	55-58
34811512-7	2022	In AR-overexpressing podocytes, Rb1 (10 muM) inhibited AR-mediated ROS overproduction and protected against high glucose-induced mitochondrial injury.	ros	67-70	RB transcriptional corepressor 1	Mus musculus	32-35
34287816-0	2022	Exosome-mediated delivery of SCD-1 siRNA promoted the death of anaplastic thyroid carcinoma cells via regulating ROS level.	ros	113-116	stearoyl-CoA desaturase	Homo sapiens	29-34
34287816-9	2022	In order to explore the mechanism of exosomes loaded SCD-1 on ATC, the ROS level was detected by fluorescence reagent.	ros	71-74	stearoyl-CoA desaturase	Homo sapiens	53-58
34287816-10	2022	It was found that exosomes loaded SCD-1 siRNA significantly increased intracellular ROS level of ATC cells (P < 0.05).	ros	84-87	stearoyl-CoA desaturase	Homo sapiens	34-39
34287816-11	2022	CONCLUSIONS: Exosomes loaded SCD-1 siRNA inhibited ATC cellular proliferation and promoted cellular apoptosis, and the mechanisms involved maybe the regulation of fatty acids metabolism and ROS level.	ros	190-193	stearoyl-CoA desaturase	Homo sapiens	29-34
34779552-6	2022	The pep-AP/TALDO1 pathway attenuates the pentose phosphate pathway (PPP), reducing NADPH/NADP+ and glutathione (GSH) levels and causing ROS accumulation and apoptosis, which sensitizes CRC cells to L-OHP in vitro and in vivo.	ros	136-139	transaldolase 1	Homo sapiens	11-17
34773414-8	2022	Thus, the "four-in-one" nanozyme@natural enzyme symbiotic system of Cu 2-x Se-GOx could significantly induce ROS accumulation at the tumor regions, which provides a potential approach for the treatment of cervical cancer.	ros	109-112	hydroxyacid oxidase 1	Homo sapiens	78-81
34808482-7	2022	We found that the production of inflammatory factors, PGE2, and COX-2 was significantly elevated in IL-17A-treated mast cells, accompanied by the activation of the iNOS/NO axis and the elevated secretion of ROS.	ros	207-210	interleukin 17A	Homo sapiens	100-106
34800882-11	2021	The treatment of Ketamine induced the levels of MDA, lipid ROS, and Fe2+, while KAT5 or GPX4 overexpression could reverse this effect in breast cancer cells.	ros	59-62	lysine acetyltransferase 5	Homo sapiens	80-84
30456799-10	2019	Gene expression of the NADPH oxidase subunits NOX2 and NOX4, which participate in ROS generation, did not differ between groups.	ros	82-85	NADPH oxidase 4	Rattus norvegicus	55-59
30316800-8	2019	We observed that iodine increased NOX4 expression and knockdown of NOX4 reduced ROS and reversed the inhibitory effect of iodine on NIS, TPO, PAX8 and TTF2 expression.	ros	80-83	NADPH oxidase 4	Rattus norvegicus	67-71
34941874-12	2021	Additionally, PNU282987 suppressed NF-kappaB/NLRP3 inflammasome activation by inhibiting the ROS/TXNIP pathway and suppressed tumor necrosis factor-alpha and IL-1beta secretion in MIA/IL-1beta-treated chondrocytes.	ros	93-96	thioredoxin interacting protein	Rattus norvegicus	97-102
34927394-11	2021	CONCLUSION: The cellular senescence induced by IL-4 through the ROS-p38 MAPK-p16INK4A pathway promoted fibrogenesis during IgG4-RS.	ros	64-67	cyclin-dependent kinase inhibitor 2A	Rattus norvegicus	77-85
30693003-9	2018	IL-17 and/or TNFalpha increased the level of the ER stress marker Grp78, mitochondrial ROS and promoted SOCE activation by 2-fold (p < 0.01) in isolated myoblasts.	ros	87-90	interleukin 17A	Homo sapiens	0-5
34563514-11	2021	Overexpression of miR-125b mimics or knockdown of STAT3 or HMGB1 alleviated LPS-induced hindrance of autophagic flux and ROS production.	ros	121-124	high mobility group box 1	Rattus norvegicus	59-64
34563514-14	2021	Hyperactivation of STAT3/HMGB1 caused by reduced miR-125b contributes to ROS generation and the hindrance of autophagic flux during septic cardiomyopathy, leading to myocardial dysfunction.	ros	73-76	high mobility group box 1	Rattus norvegicus	25-30
30571927-9	2019	One was from ROS-dependent activation of ATM via AMPK-ULK1-ATG13-Beclin1/ATG5.	ros	13-16	autophagy related 13	Homo sapiens	59-64
30571927-9	2019	One was from ROS-dependent activation of ATM via AMPK-ULK1-ATG13-Beclin1/ATG5.	ros	13-16	beclin 1	Homo sapiens	65-72
30790509-9	2019	Our data clearly showed that the NTP-mediated alternation of mitochondrial membrane potential and dynamics led to ROS-mediated apoptosis in Huh7 and Alexander cells.	ros	114-117	MIR7-3 host gene	Homo sapiens	140-144
34798192-8	2021	ZIKV-NS1 induced the expression of miR-146a and suppressed the ROS activity in human microglial cells.	ros	63-66	influenza virus NS1A binding protein	Homo sapiens	5-8
34736953-6	2021	Real-time quantitative PCR determination of marker gene expression showed that effects caused by the JAZ1 silencing might be realized through crosslinking JA, ROS, and abscisic acid signaling pathways.	ros	159-162	jasmonate-zim-domain protein 1	Arabidopsis thaliana	101-105
30747083-11	2019	Furthermore, GSP inhibited cell apoptosis, reduced the mRNA levels of CHOP, GRP78 and caspase-12 (ER stressassociated genes), restored mitochondrial membrane potential and ATP generation, improved activities of endogenous anti-oxidant ability (T-AOC, GXH-Px, and SOD), and decreased ROS level.	ros	283-286	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	Mus musculus	13-16
34864826-6	2021	But after inhibiting ROS by two kinds of ROS inhibitors NAC and SFN, the autophagy induced by CC90003 decreased, while cell death strengthened.	ros	21-24	NLR family, pyrin domain containing 1A	Mus musculus	56-59
34864826-6	2021	But after inhibiting ROS by two kinds of ROS inhibitors NAC and SFN, the autophagy induced by CC90003 decreased, while cell death strengthened.	ros	41-44	NLR family, pyrin domain containing 1A	Mus musculus	56-59
30445311-9	2019	Moreover, ROS inhibition or blocking FcgammaRIIa attenuated the decrease in GPIbalpha surface expression, platelet activation and ROS generation (for blocking FcgammaRIIa) in ITP plasma-treated platelets.	ros	10-13	glycoprotein Ib platelet subunit alpha	Homo sapiens	76-85
34926466-5	2021	Meanwhile, DRP1 inhibition resulted in mitochondrial dysfunction including decreased mitochondrial activity, loss of mitochondrial membrane potential, reduced mitochondrial copy number and inadequate ATP by disrupting both expression and activity of DRP1 and mitochondrial complex assembly, leading to excessive ROS production, severe DNA damage and cell cycle arrest at 2-cell embryo stage.	ros	312-315	collapsin response mediator protein 1	Mus musculus	11-15
34926466-5	2021	Meanwhile, DRP1 inhibition resulted in mitochondrial dysfunction including decreased mitochondrial activity, loss of mitochondrial membrane potential, reduced mitochondrial copy number and inadequate ATP by disrupting both expression and activity of DRP1 and mitochondrial complex assembly, leading to excessive ROS production, severe DNA damage and cell cycle arrest at 2-cell embryo stage.	ros	312-315	collapsin response mediator protein 1	Mus musculus	250-254
30368039-12	2019	Moreover SIRT1-inhibited cells are more resistant to 5-ALA-PDT and showing decreased ROS accumulation.	ros	85-88	sirtuin 1	Homo sapiens	9-14
30273564-9	2018	Cellular ROS stress increased and mitophagy related genes including PINK and Parkin increased along with the increased co-localization of LC3 and mitochondria.	ros	9-12	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	138-141
34601193-3	2021	En downregulated H2O2-induced mitochondrial fission/upregulated mitochondrial fusion and deletion of Mfn2 gene (i.e., shMfn2) to significantly reduce H2O2-induced ROS production.	ros	163-166	mitofusin 2	Rattus norvegicus	101-105
34410632-8	2021	In addition, recombinant Slit2 also dose-dependently increased the activity of NO, SOD, CAT and GSH-Px, and decreased TNF-alpha, IL-6, MCP-1, MDA and ROS in CHD rats.	ros	150-153	slit guidance ligand 2	Rattus norvegicus	25-30
34586588-2	2021	Here, we developed a novel sigma-2 receptor targeting thiosemicarbazone (FA4) that incorporates a moiety associated with lysosome destabilization and ROS increase in order to design more efficient antitumor agents.	ros	150-153	FA complementation group D2	Homo sapiens	73-76
30586869-7	2018	Interestingly, such combination treatments further increased intracellular ROS and cytotoxicity induced by the single TB or bortezomib treatment, suggesting that NRF2, HSF1 and p62/SQSTM1 keep the ROS level under control, allowing primary effusion lymphoma (PEL) cells to continue to survive and KSHV to replicate.	ros	75-78	sequestosome 1	Homo sapiens	177-180
34773804-0	2021	Two interaction proteins between AtPHB6 and AtSOT12 regulate plant salt resistance through ROS signaling.	ros	91-94	sulfotransferase 12	Arabidopsis thaliana	44-51
30586869-7	2018	Interestingly, such combination treatments further increased intracellular ROS and cytotoxicity induced by the single TB or bortezomib treatment, suggesting that NRF2, HSF1 and p62/SQSTM1 keep the ROS level under control, allowing primary effusion lymphoma (PEL) cells to continue to survive and KSHV to replicate.	ros	197-200	sequestosome 1	Homo sapiens	177-180
30586869-7	2018	Interestingly, such combination treatments further increased intracellular ROS and cytotoxicity induced by the single TB or bortezomib treatment, suggesting that NRF2, HSF1 and p62/SQSTM1 keep the ROS level under control, allowing primary effusion lymphoma (PEL) cells to continue to survive and KSHV to replicate.	ros	197-200	sequestosome 1	Homo sapiens	181-187
33416009-7	2021	Both NF concentrations (3 microM and 9 microM) were able to deplete ROS and lipid peroxidation, concurrently, up-regulated SOD and GST.	ros	68-71	neurofascin	Homo sapiens	5-7
34797009-0	2022	Spatial regulation of RBOHD via AtECA4-mediated recycling and clathrin-mediated endocytosis contributes to ROS accumulation upon salt stress response but not flg22-induced immune response.	ros	107-110	endomembrane-type CA-ATPase 4	Arabidopsis thaliana	32-38
30545412-0	2018	1-Pyrroline-5-carboxylate released by prostate Cancer cell inhibit T cell proliferation and function by targeting SHP1/cytochrome c oxidoreductase/ROS Axis.	ros	147-150	pyrroline-5-carboxylate reductase 1	Homo sapiens	0-25
30526498-0	2018	HyPRP1 performs a role in negatively regulating cotton resistance to V. dahliae via the thickening of cell walls and ROS accumulation.	ros	117-120	non-classical arabinogalactan protein 31	Gossypium hirsutum	0-6
34797009-5	2022	ateca4 plants that were defective in recycling of proteins from endosomes to the PM and clc2-1 and chc2-1 plants that were defective in endocytosis showed a defect in salinity stress-induced ROS production.	ros	191-194	endomembrane-type CA-ATPase 4	Arabidopsis thaliana	0-6
34173812-8	2021	Fisetin could also ameliorate and reduce oxLDL-induced upregulation of SREBP-1 and thereby expression of its downstream liposynthesis genes HMGCR and FAS via inhibiting ROS-induced NLRP3 activation.	ros	169-172	fatty acid synthase	Homo sapiens	150-153
30526498-12	2018	Additionally, silencing of HyPRP1 markedly enhanced ROS accumulation in the root tips of cotton inoculated with V. dahliae.	ros	52-55	non-classical arabinogalactan protein 31	Gossypium hirsutum	27-33
34764756-0	2021	New phthalimide analog ameliorates CCl4 induced hepatic injury in mice via reducing ROS formation, inflammation, and apoptosis.	ros	84-87	chemokine (C-C motif) ligand 4	Mus musculus	35-39
30526498-13	2018	CONCLUSIONS: Taken together, our results suggest that HyPRP1 performs a role in the negative regulation of cotton resistance to V. dahliae via the thickening of cell walls and ROS accumulation.	ros	176-179	non-classical arabinogalactan protein 31	Gossypium hirsutum	54-60
34831092-3	2021	Based upon data demonstrating reduced CTTN mRNA levels in the lungs of smokers compared to non-smokers, we hypothesized a functional role for CTTN in CS-induced mitochondrial ROS generation and apoptosis in lung EC.	ros	175-178	cortactin	Homo sapiens	142-146
34831092-7	2021	CTTN siRNA or blockade of its SH3 domain resulted in significantly increased EC mitochondrial ROS and apoptosis and augmented CSC-induced effects.	ros	94-97	cortactin	Homo sapiens	0-4
30381241-10	2018	In conclusion: our data indicate that the increased vulnerability of the diabetic myocardium to I/R-induced apoptosis/dysfunction is attributable, in part, to decreased myocardial Sirt1 activity which leads to a decrease in Akt activation, an increase in Drp1 activity, culminating in excessive mitochondrial fission and ROS production.	ros	321-324	sirtuin 1	Homo sapiens	180-185
30365930-13	2018	treatment 10 min before reperfusion decreased the level of TNF-alpha following with a negatively regulating the RIP3 induced phosphor-MLKL/CaMKII signaling, thus significantly reduced ROS production and cardiomyocyte necroptosis and ameliorated cardiac function.	ros	184-187	receptor-interacting serine-threonine kinase 3	Mus musculus	112-116
34745083-4	2021	We further found that in the absence of stimulation, increased protein levels of mitochondrial TRAF3 were associated with altered mitochondrial morphology, decreased mitochondrial respiration, increased mitochondrial ROS production and membrane permeabilization, which eventually culminated in mitochondria-dependent apoptosis in resting B cells.	ros	217-220	TNF receptor associated factor 3	Homo sapiens	95-100
30382449-5	2018	We further found that pre-treatment with ROS scavenger N-acetyl-L-cysteine (NAC) dramatically ameliorated PFOS-induced ROS production and Nrf2 signaling.	ros	41-44	X-linked Kx blood group	Homo sapiens	76-79
34664174-13	2022	ROS only decreases with Cd, FBP, and Sp at high concentrations.	ros	0-3	far upstream element (FUSE) binding protein 1	Mus musculus	28-31
30382449-5	2018	We further found that pre-treatment with ROS scavenger N-acetyl-L-cysteine (NAC) dramatically ameliorated PFOS-induced ROS production and Nrf2 signaling.	ros	119-122	X-linked Kx blood group	Homo sapiens	76-79
30236513-10	2018	To decipher the relationship between ROS generation, mitochondrial respiration flux, and AMPK signaling, mitochondrial metabolism and ROS was specifically inhibited, and the results show that AMPK inactivation and hypertrophic response in Trx2-silenced cells is reversed by respiration blockers but not ROS scavenger.	ros	134-137	thioredoxin 2	Rattus norvegicus	239-243
30236513-10	2018	To decipher the relationship between ROS generation, mitochondrial respiration flux, and AMPK signaling, mitochondrial metabolism and ROS was specifically inhibited, and the results show that AMPK inactivation and hypertrophic response in Trx2-silenced cells is reversed by respiration blockers but not ROS scavenger.	ros	134-137	thioredoxin 2	Rattus norvegicus	239-243
30190170-11	2018	A hypo-methylation of H3K4 at SOD2 promoter by LSD-1 increased ROS causing diabetic retinopathy.	ros	63-66	lysine demethylase 1A	Homo sapiens	47-52
34639144-9	2021	These data suggest that PARK7 could play a role in preventing sperm from undergoing premature capacitation, maintaining sperm viability and providing a better ability to keep ROS homeostasis, which is needed to elicit sperm capacitation.	ros	175-178	Parkinsonism associated deglycase	Sus scrofa	24-29
30240824-6	2018	In addition, miR-351-5p mimic in IEC-6 cells and agomir in mice increased ROS levels and aggravated II/R injury.	ros	74-77	membrane associated ring-CH-type finger 8	Rattus norvegicus	13-16
34403740-11	2021	Moreover, insufficient expression of Bax/Bak counteracted hypoxia-mediated downregulation of mitochondrial function, thereby adding to DHA-induced ROS production and lipid peroxidation in hypoxia.	ros	147-150	BCL2 antagonist/killer 1	Homo sapiens	41-44
34584017-9	2021	On the one hand, the up-regulation of GPR43 gene reduced ROS mitochondrial damage to inhibit inflammatory reactions via the inactivation of NLRP3 Inflammasome by PPARgamma/ Nox1/EBP50/ p47phox signal channel.	ros	57-60	free fatty acid receptor 2	Mus musculus	38-43
29966978-6	2018	Silencing of PINK1 also resulted in oxygen species (ROS) overproduction and decreased mitochondrial membrane potential.	ros	52-55	PTEN induced kinase 1	Homo sapiens	13-18
34584017-10	2021	On the other hand, the down-regulation of GPR43 promoted inflammatory reactions in vitro model through the acceleration of ROS-dependently mitochondrial damage by PPARgamma/ Nox1/EBP50/ p47phox/ NLRP3 signal channel.	ros	123-126	free fatty acid receptor 2	Mus musculus	42-47
34581906-14	2021	Furthermore, ZIP7 cKO reduced mitochondrial ROS generation and myocardial infarction via a PINK1-dependet manner, whereas overexpression of ZIP7 exacerbated myocardial infarction.	ros	44-47	PTEN induced kinase 1	Homo sapiens	91-96
34583974-0	2021	SATB1-dependent mitochondrial ROS production controls TCR signaling in CD4 T cells.	ros	30-33	SATB homeobox 1	Homo sapiens	0-5
34583974-5	2021	Impaired mitochondrial function in SATB1-deficient T cells subverts mitochondrial ROS production and SHP-1 inactivation by constitutive oxidization.	ros	82-85	SATB homeobox 1	Homo sapiens	35-40
29935235-8	2018	Selective NOX2 inhibition affected Src/Raf/Erk and PI3K/Akt pathways, without affecting the p38/PLC/PKA pathway whereas other inhibitors (ML171, VAS2870) had no effect on PACAP induced ROS generation.	ros	185-188	cytochrome b-245 beta chain	Homo sapiens	10-14
29857117-6	2018	Elimination of ROS by NAC reversed the CP-673451-induced apoptosis in NSCLC cells.	ros	15-18	X-linked Kx blood group	Homo sapiens	22-25
34638706-11	2021	Furthermore, due to this modification, a higher level of ROS is induced, which correlates with a lower level of PTP1B.	ros	57-60	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	112-117
29928961-5	2018	The effects of these drugs and inhibition and overexpression of CISD2 gene were determined by evaluating viability, cell death, lipid ROS production, mitochondrial iron, and mouse tumor xenograft models.	ros	134-137	CDGSH iron sulfur domain 2	Mus musculus	64-69
34584694-0	2021	Supranutritional selenium suppresses ROS-induced generation of RANKL-expressing osteoclastogenic CD4+ T cells and ameliorates rheumatoid arthritis.	ros	37-40	TNF superfamily member 11	Homo sapiens	63-68
29928961-9	2018	Silencing CISD2 gene rendered resistant HNC cells susceptible to sulfasalazine-induced ferroptosis, with increased levels of lipid ROS and mitochondrial ferrous iron.	ros	131-134	CDGSH iron sulfur domain 2	Mus musculus	10-15
34126574-3	2021	The curiosity in MAO inhibitors is reviving, and novel MAO-B inhibitors recently developed with ancillary activities (e.g., Abeta aggregation and AChE inhibition, anti-ROS and chelating activities) have been proposed as multitarget drugs foreshadowing a positive outlook for the treatment of AD.	ros	168-171	monoamine oxidase B	Homo sapiens	55-60
34111670-6	2021	Forced expression of miR-190a-5p inhibited GLS2, resulting in downregulation of ROS, MDA and Fe 2+ accumulation.	ros	80-83	glutaminase 2	Rattus norvegicus	43-47
34439547-8	2021	We rescue these cardiac phenotypes using antioxidant treatment, with which we conclude that the Yki induced tumorigenesis causes a systemic increase in ROS affecting cardiac function.	ros	152-155	yorkie	Drosophila melanogaster	96-99
34492938-5	2021	Subsequently, ROS-disrupted mitochondrial homeostasis, resulting from the activation of NOX2 signaling, was observed following GO internalization.	ros	14-17	cytochrome b-245 beta chain	Homo sapiens	88-92
34174417-1	2021	In order to generate an antibody directed enzyme prodrug therapy, here we designed a chimeric protein by fusing the F8 antibody that recognizes the EDA of fibronectin (expressed on the tumor neovasculature) and an evolved variant of the ROS-generating enzyme D-amino acid oxidase (DAAO).	ros	237-240	D-amino-acid oxidase	Cricetulus griseus	281-285
34294686-5	2021	Moreover, ROS generation elicited by afatinib was responsible for the induction of the REDD1-TSC1-mTORC1 axis.	ros	10-13	DNA damage inducible transcript 4	Homo sapiens	87-92
34080298-6	2021	Further underlying mechanism investigation revealed that APS attenuated activity of MAPK signalling pathways (eg ERK, JNK and p38) and ROS production induced by RANKL.	ros	135-138	TNF superfamily member 11	Homo sapiens	161-166
34163028-7	2021	Our results further demonstrate that MUC1-C integrates activation of PBRM1 with the regulation of antioxidant genes, ROS levels, pluripotency factor expression and the cancer stem cell (CSC) state.	ros	117-120	polybromo 1	Homo sapiens	69-74
34234438-1	2021	Background: Ischemic stroke is a destructive cerebrovascular disorder related to oxidative stress; NOX2 is a major source for ROS production; and miR-126a-5p is involved in several diseases, such as abdominal aortic aneurysm.	ros	126-129	cytochrome b-245 beta chain	Rattus norvegicus	99-103
34177609-12	2021	Taken together, our study demonstrated that nicotine treatment may lead to an increase in Drp1-mediated mitochondrial fission by blocking mitophagic flux by weakening the enzyme activity of CTSL and activating the ROS/p38/JNK signaling pathway.	ros	214-217	dynamin 1-like	Rattus norvegicus	90-94
34059856-6	2021	The Pt-CD/Dex-Ad@OU nano-assemblies can efficiently suppress the expression of GGT, depleting GSH and augmenting ROS via the reduction of the Pt(iv) prodrug.	ros	113-116	gamma-glutamyltransferase 1	Homo sapiens	79-82
34122722-6	2021	CIC, ACLY, and citrate are components of the citrate pathway: in LPS-activated macrophages, the mitochondrial citrate is exported by CIC into the cytosol where it is cleaved by ACLY in oxaloacetate and acetyl-CoA, precursors for ROS, NO , and PGE2 inflammatory mediators.	ros	229-232	ATP citrate lyase	Homo sapiens	177-181
34067282-10	2021	The results showed Rap1a overlaps the AGE/RAGE cascade to increase the myofibroblast population and generation of ROS production.	ros	114-117	renin binding protein	Mus musculus	38-41
34093630-8	2021	Furthermore, naringenin activates MPK6 and MPK3 in ROS-dependent, but SA-independent manners.	ros	51-54	MAP kinase 6	Arabidopsis thaliana	34-38
34093630-8	2021	Furthermore, naringenin activates MPK6 and MPK3 in ROS-dependent, but SA-independent manners.	ros	51-54	mitogen-activated protein kinase 3	Arabidopsis thaliana	43-47
34063353-3	2021	Oxidative stress appears to play a significant role in its development and experimental models have shown that an increase in cytosolic Reacttive Oxygen Speies (ROS) due to the activation of NADPH oxidase 2 (Nox2), is an early event, which damages the mitochondria, accelerating loss of capillary cells.	ros	161-164	cytochrome b-245 beta chain	Homo sapiens	191-206
34063353-3	2021	Oxidative stress appears to play a significant role in its development and experimental models have shown that an increase in cytosolic Reacttive Oxygen Speies (ROS) due to the activation of NADPH oxidase 2 (Nox2), is an early event, which damages the mitochondria, accelerating loss of capillary cells.	ros	161-164	cytochrome b-245 beta chain	Homo sapiens	208-212
35595033-8	2022	Ferritin degradation and ROS level are further increased when PINK1 or Parkin is silenced in the cells treated with ethanol or acetaldehyde.	ros	25-28	PTEN induced kinase 1	Homo sapiens	62-67
35358733-4	2022	Our research found TMZ/Fe-TSL exposed to alternating magnetic field (AMF) could induce significantly GBM cells death and promote the production of ROS.	ros	147-150	TSL	Homo sapiens	26-29
35597499-13	2022	In summary, we speculated that when psoralen causes hepatotoxicity, it acts on the direct target ABL1, resulting in a decrease in Nrf2 expression, an increase in ROS levels and a reduction in mTOR expression, which may cause cell death.	ros	162-165	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	97-101
34997266-14	2022	PQQ inhibits ROS generation and NF-kappaB activation, which stimulates activation of the NLRP3 inflammasome and regulates the expression of caspase-1, IL-1beta, and IL-18.	ros	13-16	interleukin 18	Homo sapiens	165-170
35420382-5	2022	Iron and ROS detection analyses showed that LINC01564 and SRSF1 suppress ferroptosis in glioma cells.	ros	9-12	long intergenic non-protein coding RNA 1564	Homo sapiens	44-53
35413643-4	2022	Moreover, limiting mitochondrial recruitment of Mfn2 diminished formation of the PINK1/Mfn2/Parkin complex required for initiation of mitophagy resulting in accumulation of damaged mitochondria and ROS (mtROS).	ros	198-201	mitofusin 2	Homo sapiens	48-52
35413643-4	2022	Moreover, limiting mitochondrial recruitment of Mfn2 diminished formation of the PINK1/Mfn2/Parkin complex required for initiation of mitophagy resulting in accumulation of damaged mitochondria and ROS (mtROS).	ros	198-201	PTEN induced kinase 1	Homo sapiens	81-86
35413643-4	2022	Moreover, limiting mitochondrial recruitment of Mfn2 diminished formation of the PINK1/Mfn2/Parkin complex required for initiation of mitophagy resulting in accumulation of damaged mitochondria and ROS (mtROS).	ros	198-201	mitofusin 2	Homo sapiens	87-91
35633418-3	2022	We have reported earlier that expression of human tau-transgene in Drosophila induces the expression of glob1, and its restored level restricts tau etiology by regulating tau hyperphosphorylation and ROS generation via GSK-3beta/p-Akt and Nrf2-keap1-ARE pathways, respectively.	ros	200-203	Pk34A	Drosophila melanogaster	219-228
35615146-6	2022	Further studies revealed that AD induced ROS production to down-regulate FOXM1-ER-alpha axis.	ros	41-44	forkhead box M1	Homo sapiens	73-78
35615146-7	2022	Conversely, inhibiting ROS production with N-acetylcysteine (NAC) elevated AD-decreased ER-alpha expression, which could be alleviated by FOXM1 knockdown.	ros	23-26	forkhead box M1	Homo sapiens	138-143
35521658-5	2022	Removal of domains is necessary for ATF3/Tip60 binding compromises RGS7-dependent ROS generation and cell death.	ros	82-85	lysine acetyltransferase 5	Homo sapiens	41-46
35601109-1	2022	Endosomal NOX2 oxidase-dependent ROS production promotes influenza pathogenicity, but the role of NOX4 oxidase, which is highly expressed in the lung endothelium, is largely unknown.	ros	33-36	cytochrome b-245 beta chain	Homo sapiens	10-14
35624699-12	2022	The TNF-alpha-induced NF-kappaB activation via c-Src-driven ROS was independent from the EGFR signaling pathway.	ros	60-63	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	47-52
35563730-8	2022	Moreover, TRPM2 knockout reduced the expression of ICAM-1, MCP-1, and TNFalpha and decreased the ROS level in the plaque region, suggesting a role of TRPM2 in enhancing monocyte adhesion and promoting vascular inflammation.	ros	97-100	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	10-15
29928961-11	2018	CISD2 inhibition overcomes HNC resistance to ferroptotic cell death induced by sulfasalazine via increased accumulation of mitochondrial ferrous iron and lipid ROS.	ros	160-163	CDGSH iron sulfur domain 2	Mus musculus	0-5
30298051-10	2018	Results: Pretreatment of VSMCs with AGEs-BSA increased the expression of thioredoxin-interacting protein (TXNIP) by inhibiting that of miR-146a, resulting in enhanced ROS production and VSMC calcification.	ros	167-170	thioredoxin interacting protein	Rattus norvegicus	73-104
30298051-10	2018	Results: Pretreatment of VSMCs with AGEs-BSA increased the expression of thioredoxin-interacting protein (TXNIP) by inhibiting that of miR-146a, resulting in enhanced ROS production and VSMC calcification.	ros	167-170	thioredoxin interacting protein	Rattus norvegicus	106-111
30298051-13	2018	After coculture with miR-146a-containing exosomes, the AGEs-BSA-mediated increase in VSMC calcification was diminished, accompanied by decreased TXNIP expression and ROS production.	ros	166-169	membrane associated ring-CH-type finger 8	Rattus norvegicus	21-24
29964052-9	2018	However, after ROS scavenger NAC was added to the cancer cells treated by resveratrol, DNMT1, DLC1 and senescence-associated molecular markers were reversed.	ros	15-18	DNA methyltransferase 1	Homo sapiens	87-92
35339877-5	2022	Furthermore, Mfn2 overexpression ameliorated Cu-induced MAM dysfunction, and increased Cu-evoked autophagy in duck renal tubular epithelial cells accompanied with the elevation of autophagosomes number, ROS level, LC3 puncta, Atg5 and LC3B mRNA levels, and Beclin1, Atg14, LC3BII/LC3BI protein levels.	ros	203-206	mitofusin 2	Homo sapiens	13-17
35397620-4	2022	The knockout of ICA69 in lipopolysaccharide(LPS)-induced mice markedly elevated survival ratio and heart function, while inhibiting cardiac muscle and serum inflammatory cytokines, reactive oxygen (ROS), and ferroptosis biomarkers.	ros	198-201	islet cell autoantigen 1	Mus musculus	16-21
29947028-10	2018	Pep19-2.5 increased cytosolic calcium and mitochondrial ROS, which were involved in peptide-induced migration and ERK1/2 phosphorylation.	ros	56-59	Purkinje cell protein 4	Homo sapiens	0-5
35189109-0	2022	Crosstalk between ERO1alpha and ryanodine receptor in arsenite-dependent mitochondrial ROS formation.	ros	87-90	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	18-27
35217429-6	2022	Sperm exposed to different concentrations of IFNgamma, IL-17A and IL-1beta, or a combination of them, for either 1 or 3 h showed significantly increased levels of mitochondrial ROS production and reduced motility and viability with respect to sperm incubated with vehicle.	ros	177-180	interleukin 17A	Homo sapiens	55-61
35217429-9	2022	In conclusion, our results indicate that IFNgamma, IL-17A and IL-1beta per se impair sperm motility and decreases viability by triggering increased mitochondrial ROS production and inducing sperm apoptosis.	ros	162-165	interleukin 17A	Homo sapiens	51-57
29702063-9	2018	In addition, alpha-synuclein binding alters mitochondrial function at the level of Complex I leading to a decrease in ATP synthesis and an increase of ROS production.	ros	151-154	synuclein alpha	Rattus norvegicus	13-28
28478304-4	2018	Furthermore, we provide evidence that klotho reduced levels of ROS/RNS and pro-inflammatory cytokines as well as upregulated secretion of anti-inflammatory IL-10 in LPS-treated monocytes, thus the observed DNA damage was less severe, promptly and properly fixed and cells quickly resumed normal proliferation and maintained their immune functionality.	ros	63-66	klotho	Homo sapiens	38-44
29997338-10	2018	TRPM2 is a unique TRP channel that acts as a sensor for intracellular ROS.	ros	70-73	transient receptor potential cation channel subfamily M member 2	Homo sapiens	0-5
29654216-6	2018	GATM aggregates-containing mitochondria were elongated and associated with increased ROS production, activation of the NLRP3 inflammasome, enhanced expression of the profibrotic cytokine IL-18, and increased cell death.Conclusions In this novel genetic disorder, fully penetrant heterozygous missense mutations in GATM trigger intramitochondrial fibrillary deposition of GATM and lead to elongated and abnormal mitochondria.	ros	85-88	glycine amidinotransferase	Homo sapiens	0-4
28605990-6	2018	The effects of miR-25 expression on H2O2-induced oxidative damage was evaluated by detection of cell viability, apoptosis, ROS activity, HIF-alpha and gammaH2A expression, and the level of inflammatory mediators.	ros	123-126	microRNA 25	Rattus norvegicus	15-21
29695835-6	2018	TERT silencing or treatment of NRAS-mutant melanoma with the telomerase-dependent telomere uncapping agent, 6-thio-2"-deoxyguanosine (6-thio-dG), led to rapid cell death, along with evidence of both telomeric and non-telomeric DNA damage, increased ROS levels, and upregulation of a mitochondrial antioxidant adaptive response.	ros	249-252	NRAS proto-oncogene, GTPase	Homo sapiens	31-35
29235191-6	2018	RESULTS: C3G increased the cell viability of primary HDFs and decreased UVA-induced ROS production and apoptosis rate.	ros	84-87	Rap guanine nucleotide exchange factor 1	Homo sapiens	9-12
29702141-5	2018	DRm217 produced protective effect via stabilizing Na+-K+-ATPase membrane expression and inhibiting Na+-K+-ATPase/Src/NADPH oxidase dependent ROS accumulation.	ros	141-144	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	113-116
29626473-6	2018	In conclusion, our data suggest that GAPDS overexpression antagonize high glucose-induced apoptosis by controlling ROS accumulation in TM3 cells.	ros	115-118	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	37-42
29605485-7	2018	Our results showed a significant elevation in TBARS level after administration of Abeta causing mitochondrial ROS generation, swelling, outer membrane damage, cytochrome C release and also lower thiol, FRAP, and MMP levels.	ros	110-113	amyloid beta precursor protein	Rattus norvegicus	82-87
29680745-2	2018	Extracellular CyPA plays a prominent role in the pathological processes of inflammatory diseases, acting as a proinflammatory mediator, exerting chemotactic effects, promoting apoptosis of endothelial cells and amplifying ROS generation, thus being considered as a potential treatment target of sepsis, a systemic inflammatory response syndrome.	ros	222-225	peptidylprolyl isomerase A	Mus musculus	14-18
29524841-8	2018	In addition, the level of intracellular ROS was significantly increased in H9C2 cells treated by DOX after miR-140-5p mimic transfection, as well as the down-regulated expression levels of Nrf2 and Sirt2, which were markedly reversed by dioscin.	ros	40-43	sirtuin 2	Rattus norvegicus	198-203
29851986-6	2018	However, PARP1 binding to Polymerase gamma and mtDNA in mitochondria were increased, and associated with a loss in mtDNA content, mtDNA-encoded gene expression, and oxidative phosphorylation (OXPHOS) capacity, and an increase in mitochondrial ROS production in cells and heart of WT mice infected with T. cruzi.	ros	243-246	poly (ADP-ribose) polymerase family, member 1	Mus musculus	9-14
29851986-6	2018	However, PARP1 binding to Polymerase gamma and mtDNA in mitochondria were increased, and associated with a loss in mtDNA content, mtDNA-encoded gene expression, and oxidative phosphorylation (OXPHOS) capacity, and an increase in mitochondrial ROS production in cells and heart of WT mice infected with T. cruzi.	ros	243-246	polymerase (DNA directed), gamma	Mus musculus	26-42
29654773-6	2018	PSP-2 caused the increase of intracellular ROS level and the decrease of Bcl-2/Bax ratio, and triggered the activation of p53 and caspases-3 in DU145 cells.	ros	43-46	regenerating family member 1 beta	Homo sapiens	0-5
29875661-6	2018	Further mechanism study revealed that the pro-senescence effect of shikonin was dependent on the increased intercellular ROS generation, which subsequently triggered DNA damage-p53/p21waf axis without activating oncogenes such as Ras and MEK-1.	ros	121-124	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	181-187
29626628-8	2018	We also observed that elevated expression of LASS2 in mouse hepatocyte cell line AML12 obviously decreased V-ATPase activity and increased ROS level by activation of p38 MAPK and ERK1/ERK2 signaling.	ros	139-142	ceramide synthase 2	Mus musculus	45-50
29746571-8	2018	These results argue that ROS production, triggered by IIV-6 infection, leads to p38b activation and unpaired expression, and subsequent JAK-STAT signaling, which ultimately protects the fly from IIV-6 infection.	ros	25-28	p38b MAP kinase	Drosophila melanogaster	80-84
29499168-6	2018	Pretreatment of ROS scavenger (NAC) significantly inhibited DEP-induced IL-17A mRNA expression.	ros	16-19	interleukin 17A	Homo sapiens	72-78
29499168-10	2018	These results indicate DEP stimulates IL-17A expression in airway epithelium through ROS/NF-kappaB pathway, and provide a possible link between traffic pollution exposure and IL-17A-related responses in severe allergic asthma patients.	ros	85-88	interleukin 17A	Homo sapiens	38-44
29512938-0	2018	FGF1 improves functional recovery through inducing PRDX1 to regulate autophagy and anti-ROS after spinal cord injury.	ros	88-91	fibroblast growth factor 1	Rattus norvegicus	0-4
35192544-5	2022	Tc9 cell-derived IL-9 activated STAT3, upregulated fatty acid oxidation and mitochondrial activity, and rendered Tc9 cells with reduced lipid peroxidation and resistant to tumor or ROS induced ferroptosis in TME.	ros	181-184	interleukin 9	Mus musculus	17-21
29512938-6	2018	Taken together, these results suggest that FGF1 improves functional recovery mainly through inducing PRDX1 expression to increase autophagy and anti-ROS activity after SCI.	ros	149-152	fibroblast growth factor 1	Rattus norvegicus	43-47
29490083-5	2018	Root hairs of mutants in CAS-C1 or RHD2/AtrbohC, whose protein product catalyzes the generation of ROS and the Ca2+ gradient, start to grow out correctly, but they do not elongate.	ros	99-102	NADPH/respiratory burst oxidase protein D	Arabidopsis thaliana	35-39
35322093-6	2022	The eIF5G31R mutant cells showed lower glutathione levels, high ROS activity, and sensitivity to H2O2.	ros	64-67	eukaryotic translation initiation factor 5	Homo sapiens	4-8
29335220-4	2018	In turn, excessive ROS induced caspase-3-dependent PKCdelta activation and stimulated NF-kappaB p65 nuclear translocation, resulting in inflammation in the mouse hippocampus.	ros	19-22	caspase 3	Mus musculus	31-40
35288580-5	2022	beta-cell-specific Tfeb knockout (TfebDeltabeta-cell) abrogated high-fat diet (HFD)-induced mitophagy, accompanied by increased ROS and reduced mitochondrial cytochrome c oxidase activity or O2 consumption.	ros	128-131	transcription factor EB	Mus musculus	19-23
29335220-4	2018	In turn, excessive ROS induced caspase-3-dependent PKCdelta activation and stimulated NF-kappaB p65 nuclear translocation, resulting in inflammation in the mouse hippocampus.	ros	19-22	protein kinase C, delta	Mus musculus	51-59
29335220-7	2018	Our data further showed that activation of ROS-PKCdelta signaling was associated with DJ-1 downregulation, which exerted neuroprotective effects against oxidative stress induced by different neurotoxic agents.	ros	43-46	protein kinase C, delta	Mus musculus	47-55
35308176-8	2022	The ROS level was increased and cell viability was decreased in a dose- and time-dependent manner, while those were recovered when cotreated with NAC.	ros	4-7	X-linked Kx blood group	Homo sapiens	146-149
29285593-7	2018	Intra- and extracellular Klotho remarkably ameliorated viability inhibition, ROS generation, and cellular apoptosis induced by H2O2.	ros	77-80	klotho	Mus musculus	25-31
35258392-4	2022	Mechanistically, OXPHOS constitutively generates low levels of endogenous ROS that induce autophagy via attenuation of ATG4B activity, which provides protection from ROS insult.	ros	74-77	autophagy related 4B, cysteine peptidase	Mus musculus	119-124
35258392-4	2022	Mechanistically, OXPHOS constitutively generates low levels of endogenous ROS that induce autophagy via attenuation of ATG4B activity, which provides protection from ROS insult.	ros	166-169	autophagy related 4B, cysteine peptidase	Mus musculus	119-124
35258392-6	2022	Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.Abbreviations: AMPK: AMP-activated protein kinase; AOX: alternative oxidase; Baf A: bafilomycin A1; CI, respiratory complexes I; DCF-DA: 2",7"-dichlordihydrofluorescein diacetate; DHE: dihydroethidium; DSS: dextran sodium sulfate; DeltaPsimi: mitochondrial inner membrane potential; EdU: 5-ethynyl-2"-deoxyuridine; ETC: electron transport chain; FA: formaldehyde; HUVEC; human umbilical cord endothelial cells; IBD: inflammatory bowel disease; LC3B: microtubule associated protein 1 light chain 3 beta; LPS: lipopolysaccharide; MEFs: mouse embryonic fibroblasts; MTORC1: mechanistic target of rapamycin kinase complex 1; mtDNA: mitochondrial DNA; NAC: N-acetyl cysteine; OXPHOS: oxidative phosphorylation; PCs: proliferating cells; PE: phosphatidylethanolamine; PEITC: phenethyl isothiocyanate; QCs: quiescent cells; ROS: reactive oxygen species; PLA2: phospholipase A2, WB: western blot.	ros	126-129	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	258-262
35258392-6	2022	Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.Abbreviations: AMPK: AMP-activated protein kinase; AOX: alternative oxidase; Baf A: bafilomycin A1; CI, respiratory complexes I; DCF-DA: 2",7"-dichlordihydrofluorescein diacetate; DHE: dihydroethidium; DSS: dextran sodium sulfate; DeltaPsimi: mitochondrial inner membrane potential; EdU: 5-ethynyl-2"-deoxyuridine; ETC: electron transport chain; FA: formaldehyde; HUVEC; human umbilical cord endothelial cells; IBD: inflammatory bowel disease; LC3B: microtubule associated protein 1 light chain 3 beta; LPS: lipopolysaccharide; MEFs: mouse embryonic fibroblasts; MTORC1: mechanistic target of rapamycin kinase complex 1; mtDNA: mitochondrial DNA; NAC: N-acetyl cysteine; OXPHOS: oxidative phosphorylation; PCs: proliferating cells; PE: phosphatidylethanolamine; PEITC: phenethyl isothiocyanate; QCs: quiescent cells; ROS: reactive oxygen species; PLA2: phospholipase A2, WB: western blot.	ros	126-129	NLR family, pyrin domain containing 1A	Mus musculus	890-893
35258392-6	2022	Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.Abbreviations: AMPK: AMP-activated protein kinase; AOX: alternative oxidase; Baf A: bafilomycin A1; CI, respiratory complexes I; DCF-DA: 2",7"-dichlordihydrofluorescein diacetate; DHE: dihydroethidium; DSS: dextran sodium sulfate; DeltaPsimi: mitochondrial inner membrane potential; EdU: 5-ethynyl-2"-deoxyuridine; ETC: electron transport chain; FA: formaldehyde; HUVEC; human umbilical cord endothelial cells; IBD: inflammatory bowel disease; LC3B: microtubule associated protein 1 light chain 3 beta; LPS: lipopolysaccharide; MEFs: mouse embryonic fibroblasts; MTORC1: mechanistic target of rapamycin kinase complex 1; mtDNA: mitochondrial DNA; NAC: N-acetyl cysteine; OXPHOS: oxidative phosphorylation; PCs: proliferating cells; PE: phosphatidylethanolamine; PEITC: phenethyl isothiocyanate; QCs: quiescent cells; ROS: reactive oxygen species; PLA2: phospholipase A2, WB: western blot.	ros	126-129	phospholipase A2, group IB, pancreas	Mus musculus	1090-1094
35258392-6	2022	Hence, cells acquired mitochondria during evolution to profit from oxidative metabolism, but also built in an autophagy-based ROS-induced protective mechanism to guard against oxidative stress associated with OXPHOS function during quiescence.Abbreviations: AMPK: AMP-activated protein kinase; AOX: alternative oxidase; Baf A: bafilomycin A1; CI, respiratory complexes I; DCF-DA: 2",7"-dichlordihydrofluorescein diacetate; DHE: dihydroethidium; DSS: dextran sodium sulfate; DeltaPsimi: mitochondrial inner membrane potential; EdU: 5-ethynyl-2"-deoxyuridine; ETC: electron transport chain; FA: formaldehyde; HUVEC; human umbilical cord endothelial cells; IBD: inflammatory bowel disease; LC3B: microtubule associated protein 1 light chain 3 beta; LPS: lipopolysaccharide; MEFs: mouse embryonic fibroblasts; MTORC1: mechanistic target of rapamycin kinase complex 1; mtDNA: mitochondrial DNA; NAC: N-acetyl cysteine; OXPHOS: oxidative phosphorylation; PCs: proliferating cells; PE: phosphatidylethanolamine; PEITC: phenethyl isothiocyanate; QCs: quiescent cells; ROS: reactive oxygen species; PLA2: phospholipase A2, WB: western blot.	ros	126-129	phospholipase A2, group IB, pancreas	Mus musculus	1096-1112
28497199-4	2018	AA has been shown to induce ROS generation through activation of NADPH oxidases (Noxs) which may play a key role in the expression of heme oxygenase-1 (HO-1).	ros	28-31	heme oxygenase 1	Rattus norvegicus	134-150
28497199-4	2018	AA has been shown to induce ROS generation through activation of NADPH oxidases (Noxs) which may play a key role in the expression of heme oxygenase-1 (HO-1).	ros	28-31	heme oxygenase 1	Rattus norvegicus	152-156
28497199-8	2018	AA-induced HO-1 expression was mediated through Nox/ROS generation, which was inhibited by Nox inhibitors (diphenyleneiodonium and apocynin) and ROS scavengers (N-acetyl cysteine).	ros	52-55	heme oxygenase 1	Rattus norvegicus	11-15
35268078-7	2022	Compared to the NEG, the CPE decreased to 22% of the ROS generation and significantly increased cell viability in vitro.	ros	53-56	carboxypeptidase E	Mus musculus	25-28
28497199-8	2018	AA-induced HO-1 expression was mediated through Nox/ROS generation, which was inhibited by Nox inhibitors (diphenyleneiodonium and apocynin) and ROS scavengers (N-acetyl cysteine).	ros	145-148	heme oxygenase 1	Rattus norvegicus	11-15
29446486-0	2018	Interleukin-17A participates in podocyte injury by inducing IL-1beta secretion through ROS-NLRP3 inflammasome-caspase-1 pathway.	ros	87-90	interleukin 17A	Homo sapiens	0-15
29428410-8	2018	Mechanistic studies showed that these inhibitors could release Nrf2 in H9c2 cells and LPS-inflammatory mouse models and translocate into the nucleus in a dose-response manner, which significantly increased the downstream genes (HO-1, NQO-1) and the pro-inflammatory cytokines (TNF-alpha, IL-1beta, IL-6), while ROS production dramatically decreased.	ros	311-314	NAD(P)H dehydrogenase, quinone 1	Mus musculus	234-239
29773098-10	2018	Conclusion Polydatin up-regulates the expression of SIRT1 to increase the ability of anti-macrophage proliferation, reduce the level of the intracellular ROS induced by ox-LDL, and inhibit the expression of inflammatory cytokines.	ros	154-157	sirtuin 1	Homo sapiens	52-57
35233582-4	2022	RESULTS: Tunicamycin could significantly increase the ROS content and the apoptosis rate in HTMC and GTM3 (p<0.01).	ros	54-57	glutathione S-transferase mu 3	Homo sapiens	101-105
35100813-8	2022	Also, the increased ROS generation and NADPH consumption were accelerated by MIOX overexpression, and they were mitigated by Nec-1 administration.	ros	20-23	myo-inositol oxygenase	Mus musculus	77-81
35091288-6	2022	Further research indicated that IA-1 induced significant DNA damage and ROS generation, accompanied by high cellular platinum accumulation, resulting in a much higher apoptosis rate than cisplatin in A2780 cells.	ros	72-75	INSM transcriptional repressor 1	Homo sapiens	32-36
35299735-2	2022	The adjuvant treatment of ROS Proto-Oncogene 1 (ROS1) fusion-positive resected NSCLC is challenging because there is no curative confirmed randomized controlled trial.	ros	26-29	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	48-52
35023144-4	2022	The involvement of ROS signaling in HSP70-induced inflammation was explored in THP-1 cells with or without N-acetyl- l-cysteine (NAC) pretreatment.	ros	19-22	heat shock protein family A (Hsp70) member 4	Homo sapiens	36-41
35023144-9	2022	After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC.	ros	141-144	interleukin 18	Homo sapiens	70-84
35023144-9	2022	After HSP70 stimulation, the expression of ROS, NLRP3, Caspase-1, and interleukin-18 (IL-18) increased significantly and could be reduced by ROS inhibitor NAC.	ros	141-144	interleukin 18	Homo sapiens	86-91
35232995-6	2022	Loss of PDK1 activity releases glycolytic cells into an OXPHOS state associated with increased ROS levels resulting in enhanced apoptosis in leukemic but not in healthy stem/progenitor cells.	ros	95-98	pyruvate dehydrogenase kinase 1	Homo sapiens	8-12
35153295-6	2022	Knock-down of circPUM1 would result in lower intracellular oxygen concentration, downregulated oxidative phosphorylation, decrease of mitochondrial membrane potential, increase of ROS generation and shrinking of mitochondria, respectively.	ros	180-183	pumilio RNA binding family member 1	Homo sapiens	14-22
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	ros	318-321	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	ros	318-321	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	ros	318-321	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	ros	318-321	2,4-dienoyl-CoA reductase 1	Homo sapiens	238-243
35158017-3	2022	In reaction to increased ROS, the anti-oxidative master transcription factor, Transient receptor potential Ankyrin 1(TRPA1) allows Ca2+ ions to enter cells.	ros	25-28	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	117-122
35158017-12	2022	Our results suggest that functional blockade of TRPA1 might be a promising therapeutic intervention related to ROS and Nrf2 in TBI.	ros	111-114	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	48-53
35204227-9	2022	In addition, treatment of TGEV-infected IPEC-J2 cells with the ROS inhibitors (NAC) significantly reduced the protein levels of p-P38MAPK, Fas, Bax, and Cleaved-caspase-3 and the percentage of apoptotic cells.	ros	63-66	Fas cell surface death receptor	Sus scrofa	139-142
35185572-6	2022	The ROS content in the cells of co-treated with isoorientin and oleic acid was significantly reduced compared to the oleic acid group, and the expression of gammaH2AX, HO-1, PPARgamma, SREBP-1c, FAS, and the nuclear translocation of NF-kappaB p65 were also significantly inhibited.	ros	4-7	heme oxygenase 1	Rattus norvegicus	168-172
35185572-6	2022	The ROS content in the cells of co-treated with isoorientin and oleic acid was significantly reduced compared to the oleic acid group, and the expression of gammaH2AX, HO-1, PPARgamma, SREBP-1c, FAS, and the nuclear translocation of NF-kappaB p65 were also significantly inhibited.	ros	4-7	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	174-183
35186974-7	2021	Moreover, HIF-1alpha-Parkin/PINK1-mediated mitophagy prevented apoptosis and ROS production in HK-2 cells subjected to HG exposure.	ros	77-80	PTEN induced kinase 1	Homo sapiens	28-33
35115501-5	2022	NO, by gating Schwann cell transient receptor potential ankyrin 1 (TRPA1), releases ROS, which in a feed-forward manner sustain allodynia via nociceptor TRPA1.	ros	84-87	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	27-65
35115501-5	2022	NO, by gating Schwann cell transient receptor potential ankyrin 1 (TRPA1), releases ROS, which in a feed-forward manner sustain allodynia via nociceptor TRPA1.	ros	84-87	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	67-72
35115501-5	2022	NO, by gating Schwann cell transient receptor potential ankyrin 1 (TRPA1), releases ROS, which in a feed-forward manner sustain allodynia via nociceptor TRPA1.	ros	84-87	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	153-158
35052641-5	2022	Overall, our data implicate ROS-PKD1 signaling as a common feature of different inducers of pancreatic ADM.	ros	28-31	protein kinase D1	Homo sapiens	32-36
35052632-0	2022	Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) Counteracts UV-B Radiation-Induced ROS Formation in Corneal Epithelium.	ros	107-110	catenin beta like 1	Homo sapiens	67-70
35052632-7	2022	Our results showed that NAP treatment prevents ROS formation by reducing UV-B-irradiation-induced apoptotic cell death and JNK signalling pathway activation.	ros	47-50	catenin beta like 1	Homo sapiens	24-27
29416015-1	2018	Emerging evidence supports an important role for the ROS-sensitive TRPM2 channel in mediating age-related cognitive impairment in Alzheimer"s disease (AD), particularly neurotoxicity resulting from generation of excessive neurotoxic Abeta peptides.	ros	53-56	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	67-72
29416015-7	2018	Bafilomycin-induced lysosomal dysfunction also resulted in TRPM2-dependent cytosolic Zn2+ increase, mitochondrial Zn2+ accumulation, and mitochondrial generation of ROS, supporting that lysosomal dysfunction and accompanying Zn2+ release trigger mitochondrial Zn2+ accumulation and generation of ROS.	ros	296-299	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	59-64
28940008-8	2018	Furthermore, depletion of p21 by siRNA enhanced Dex-induced caspase-3 activation and ROS generation, and promoted apoptosis of MC3T3-E1 cells.	ros	85-88	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	26-29
29148034-10	2018	CONCLUSION AND IMPLICATIONS: In our model, p62 exerted a specific, autophagy-independent role and protected against efavirenz-induced mitochondrial ROS generation and activation of the NLRP3 inflammasome.	ros	148-151	sequestosome 1	Homo sapiens	43-46
29320894-2	2018	Since the glutathione (GSH) and thioredoxin (TRX) systems cooperate to a tight regulation of ROS in cell physiology, and to a stimulation of tumour initiation and progression, modulation of the GSH and TRX pathways are emerging as new potential targets in cancer.	ros	93-96	thioredoxin 1	Mus musculus	45-48
29085959-2	2018	We found that IGFBP-6 increased ROS production (cytofluorimetry), degranulation of primary and tertiary granules (ELISA) and transmigration through the epithelial monolayer.	ros	32-35	insulin like growth factor binding protein 6	Homo sapiens	14-21
29307831-8	2018	Furthermore, NAC, an ROS scavenger, abrogated the effects of ATO on TFEB-dependent autophagic cell death.	ros	21-24	X-linked Kx blood group	Homo sapiens	13-16
29037867-5	2018	Using SPR analysis and enzyme activity assay on recombinant TrxR1 protein, our results show that CTD directly binds and inhibits the activity of TrxR1, which caused enhanced generation of ROS and led to ROS-dependent endoplasmic reticulum stress and cell apoptosis in colon cancer cells.	ros	188-191	thioredoxin reductase 1	Homo sapiens	60-65
29037867-5	2018	Using SPR analysis and enzyme activity assay on recombinant TrxR1 protein, our results show that CTD directly binds and inhibits the activity of TrxR1, which caused enhanced generation of ROS and led to ROS-dependent endoplasmic reticulum stress and cell apoptosis in colon cancer cells.	ros	188-191	thioredoxin reductase 1	Homo sapiens	145-150
29037867-5	2018	Using SPR analysis and enzyme activity assay on recombinant TrxR1 protein, our results show that CTD directly binds and inhibits the activity of TrxR1, which caused enhanced generation of ROS and led to ROS-dependent endoplasmic reticulum stress and cell apoptosis in colon cancer cells.	ros	203-206	thioredoxin reductase 1	Homo sapiens	60-65
29037867-5	2018	Using SPR analysis and enzyme activity assay on recombinant TrxR1 protein, our results show that CTD directly binds and inhibits the activity of TrxR1, which caused enhanced generation of ROS and led to ROS-dependent endoplasmic reticulum stress and cell apoptosis in colon cancer cells.	ros	203-206	thioredoxin reductase 1	Homo sapiens	145-150
29037867-6	2018	Overexpression of TrxR1 in HCT116 cells reversed CTD-induced cell apoptosis and ROS increase.	ros	80-83	thioredoxin reductase 1	Homo sapiens	18-23
28812210-13	2018	In addition, TNFRII antagonist but not IL-1betaR antagonist could restrict the production of ROS, expression of IL-6 and generation of Th17 cells.	ros	93-96	TNF receptor superfamily member 1B	Homo sapiens	13-19
29216509-6	2018	Additionally, more cadmium-treated cells underwent apoptosis than BDE-209-treated cells while more ROS was generated with BDE-209 treatment, indicating that other mechanisms might be involved in cadmium-induced apoptosis.	ros	99-102	homeobox D13	Homo sapiens	122-125
32291017-8	2018	This concept is based on reciprocal activation of NADPH oxidases by cytosolic Ca2+ on the one hand, and Ca2+-permeable channels that are activated by NADPH-produced ROS.	ros	165-168	2,4-dienoyl-CoA reductase 1	Homo sapiens	50-55
32291017-8	2018	This concept is based on reciprocal activation of NADPH oxidases by cytosolic Ca2+ on the one hand, and Ca2+-permeable channels that are activated by NADPH-produced ROS.	ros	165-168	2,4-dienoyl-CoA reductase 1	Homo sapiens	150-155
32291017-15	2018	Importantly, the origin of ROS for induction of autophagy and cell death varies in different tissues and comprises several pools, including NADPH oxidases, peroxidases, photosynthetic and respiratory electron-transporting chains and peroxisomal enzymes.	ros	27-30	2,4-dienoyl-CoA reductase 1	Homo sapiens	140-145
29479032-6	2018	However, DPI and NAC (inhibitor of ROS) in supplement restored PM2.5-induced mitochondrial disorder.	ros	35-38	X-linked Kx blood group	Homo sapiens	17-20
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	Kelch-like ECH-associated protein 1	Rattus norvegicus	144-149
28986066-5	2017	Here, we found that concomitant with deacetylating and reducing the ubiquitination levels of Nrf2, Sirt1 significantly enhanced the activity of Keap1/Nrf2/ARE pathway including decreasing Keap1 expression, promoting the nuclear content, ARE-binding ability, and transcriptional activity of Nrf2, augmenting the protein levels of heme oxygenase 1, a target gene of Nrf2, which eventually quenched ROS overproduction and alleviating FN and TGF-beta1 accumulation in AGEs-treated GMCs.	ros	396-399	heme oxygenase 1	Rattus norvegicus	329-345
28767201-9	2017	And inhibition of HO-1 with Znpp decreased the inhibitory effects of D-4F on neointimal formation and ROS production in arteries.	ros	102-105	heme oxygenase 1	Rattus norvegicus	18-22
28878027-6	2017	Functional analyses revealed that ROS-mediated FOXO activation and proapoptotic factors BIK, BIM, and BMF were important to apoptosis induction following HDAC inhibition in synovial sarcoma.	ros	34-37	histone deacetylase 9	Homo sapiens	154-158
29249972-3	2017	Transient receptor potential ankyrin 1 (TRPA1), the most sensitive TRP channel to ROS, was shown to be responsible for urinary bladder abnormalities and hyperalgesia in an acute cystitis model.	ros	82-85	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-38
29249972-3	2017	Transient receptor potential ankyrin 1 (TRPA1), the most sensitive TRP channel to ROS, was shown to be responsible for urinary bladder abnormalities and hyperalgesia in an acute cystitis model.	ros	82-85	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	40-45
28863382-9	2017	Altered enzymic and ROS levels in-vivo by 9f were implicated in suppressed VEGF secretion leading to regressed tumor neovasculature and tumor growth.	ros	20-23	vascular endothelial growth factor A	Mus musculus	75-79
28697922-0	2017	GL-V9 induced upregulation and mitochondrial localization of NAG-1 associates with ROS generation and cell death in hepatocellular carcinoma cells.	ros	83-86	growth differentiation factor 15	Homo sapiens	61-66
28642114-6	2017	The results demonstrated that ACP1 not only attenuated ROS production, but also decreased expressions of TNF-alpha and IL-1beta.	ros	55-58	acid phosphatase 1	Homo sapiens	30-34
28757527-8	2017	Inhibition of RAD51 also increased ROS levels and led to an abnormal mitochondrial distribution.	ros	35-38	RAD51 recombinase	Homo sapiens	14-19
28946937-10	2017	Our data also suggest that secreted IL-6 regulates CLB2.0-induced MUC5AC and MUC1 expression via ROS-mediated downregulation of claudin-1 expression to maintain mucus homeostasis in the airway.	ros	97-100	claudin 1	Homo sapiens	128-137
28655711-3	2017	We found that ROS induced a robust expression of FOXD3-AS1 in mouse lung tissue.	ros	14-17	forkhead box D3	Mus musculus	49-54
28884428-9	2017	The complex induces EAC cell apoptosis through a ROS-mediated mitochondrial pathway by activating caspase 3 and caspase 7 and regulates the Bcl-2 family proteins.	ros	49-52	caspase 3	Mus musculus	98-107
28979688-8	2017	In vitro, flow cytometry showed that human recombinant IL-25 (rIL-25) led to increased cell apoptosis and ROS in the human epithelial cell line 16HBE in a dose and time-dependent fashion.	ros	106-109	interleukin 25	Homo sapiens	55-60
28979688-10	2017	In vitro, IL-25 increased the number of apoptotic cells and the production of ROS in16HBE cells.	ros	78-81	interleukin 25	Homo sapiens	10-15
28900305-10	2017	BBR also markedly reduced Nox2-dependent cytoplasmic ROS production and mitochondrial ROS production, which was mediated by the down-regulation of Complex I and III expression.	ros	53-56	cytochrome b-245 beta chain	Homo sapiens	26-30
28578014-6	2017	We found that CO induced sestrin-2 (SESN2) expression through enhanced mitochondrial ROS production and protected against MCD-induced NAFLD progression through activation of autophagy.	ros	85-88	sestrin 2	Mus musculus	25-34
28578014-6	2017	We found that CO induced sestrin-2 (SESN2) expression through enhanced mitochondrial ROS production and protected against MCD-induced NAFLD progression through activation of autophagy.	ros	85-88	sestrin 2	Mus musculus	36-41
28827764-6	2017	NOX complexes increased endosomal ROS levels that were permeable into cytoplasm, leading to NF-kappaB-mediated ICAM1 up-regulation.	ros	34-37	intercellular adhesion molecule 1	Homo sapiens	111-116
28575497-0	2017	Loss of hepatic LRPPRC alters mitochondrial bioenergetics, regulation of permeability transition and trans-membrane ROS diffusion.	ros	116-119	leucine rich pentatricopeptide repeat containing	Homo sapiens	16-22
28771687-6	2017	Finally, it was observed that the 2-oxoglutarate dehydrogenase (OGDH) inhibitors 3-methyl-2-oxovaleric acid (KMV) and CPI-613 inhibit the formate-induced increase in pyruvate-driven ROS production.	ros	182-185	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	Mus musculus	34-62
28771687-6	2017	Finally, it was observed that the 2-oxoglutarate dehydrogenase (OGDH) inhibitors 3-methyl-2-oxovaleric acid (KMV) and CPI-613 inhibit the formate-induced increase in pyruvate-driven ROS production.	ros	182-185	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	Mus musculus	64-68
28740219-1	2017	p66shc is a growth factor adaptor protein that contributes to mitochondrial ROS production.	ros	76-79	src homology 2 domain-containing transforming protein C1	Mus musculus	0-6
27925196-7	2017	Our results demonstrate that SIRT1-silenced cells are more resistant to H2 O2 and etoposide treatment showing decreased ROS accumulation, gamma-H2AX phosphorylation, caspase-3 activation and PARP cleavage.	ros	120-123	sirtuin 1	Homo sapiens	29-34
28978040-7	2017	Overall, our results show that cN-II regulates the cellular response to glucose deprivation through a mechanism related to ROS metabolism and defence.	ros	123-126	5'-nucleotidase, cytosolic II	Homo sapiens	31-36
28614802-6	2017	ccRCC CD8 TIL were unable to efficiently uptake glucose or perform glycolysis and had small, fragmented mitochondria that were hyperpolarized and generated large amounts of ROS.	ros	173-176	CD8a molecule	Homo sapiens	6-9
28263796-9	2017	TRPC inhibitor SKF96365 or siRNA knockdown of TRPC6 attenuated insulin-dependent increase of ROS production.	ros	93-96	transient receptor potential cation channel, subfamily C, member 6	Rattus norvegicus	46-51
27883213-9	2017	Taken together, our results point out that the Abeta toxicity mechanism involves an oxidative stress induction by increasing ROS production into the mitochondria, where Cta1 and Sod2 play a crucial role in the regulation of the redox balance.	ros	125-128	superoxide dismutase SOD2	Saccharomyces cerevisiae S288C	178-182
27748761-0	2017	Phosphorylation of cofilin-1 by ERK confers HDAC inhibitor resistance in hepatocellular carcinoma cells via decreased ROS-mediated mitochondria injury.	ros	118-121	histone deacetylase 9	Homo sapiens	44-48
27813153-6	2017	ICT, by inhibiting the TRAF6/c-Src/PI3K pathway, suppressed NADPH oxidase-1 activation to attenuate intracellular ROS production and downregulate calcineurin phosphatase activity.	ros	114-117	NADPH oxidase 1	Rattus norvegicus	60-75
27813153-11	2017	Put together, we present novel findings that ICT, by downregulating TRAF6, coordinates inhibition of NF-kappaB, MAPK/AP-1, and ROS signaling pathways to reduce expression and activity of NFATc1.	ros	127-130	TNF receptor associated factor 6	Rattus norvegicus	68-73
28165467-13	2017	We also found that TGF-beta stimulated ROS generation in primary mouse mesangial cells (pMMCs) from wild-type, Nox1 KO, and Duox1 KO mice, but did not induce Nox activity in pMMCs from Nox2 knockout (KO), Nox4 KO, or Duox2 KO mice.	ros	39-42	dual oxidase 1	Mus musculus	124-129
28358377-8	2017	Knockdown of phosphatase and tensin homolog-induced putative kinase 1 (PINK1) inhibited the BAY-induced Deltapsi depolarization, mitophagy stimulation, ROS increase and cell death.	ros	152-155	PTEN induced kinase 1	Homo sapiens	13-69
28358377-8	2017	Knockdown of phosphatase and tensin homolog-induced putative kinase 1 (PINK1) inhibited the BAY-induced Deltapsi depolarization, mitophagy stimulation, ROS increase and cell death.	ros	152-155	PTEN induced kinase 1	Homo sapiens	71-76
28322340-2	2017	Here we investigated the role of ROS-sensitive TRPM2 channel in H2O2/Zn2+-induced Ca2+ signalling and cell death in microglial cells.	ros	33-36	transient receptor potential cation channel subfamily M member 2	Homo sapiens	47-52
27189055-6	2017	Furthermore, pretreatment with N-acetyl-L-cysteine (NAC) could alleviate the damage by causing a remarkable decrease in ROS production and mitochondrial dysfunction.	ros	120-123	X-linked Kx blood group	Homo sapiens	52-55
28011619-5	2017	This conjugation event attenuated reversible thiol reduction of Trx1, leading to ROS accumulation and a broader degradation of thiol redox homeostasis in cancer cells.	ros	81-84	thioredoxin 1	Mus musculus	64-68
28108387-4	2017	Pretreatment with MAO-B selective inhibitor selegiline reversed the CSM-induced changes in MAO-B activity, ROS levels and IL-8 release in a dose-dependent manner.	ros	107-110	monoamine oxidase B	Homo sapiens	18-23
27890624-8	2017	Using H89, inhibitor of the protein kinase A (PKA), and protease inhibitors, evidences have been obtained that ROS-dependent apoptosis is associated with an alteration of mitochondrial cAMP/PKA signal that causes degradation/proteolysis of Sirt3 that, in turn, promotes acetylation and proteolytic processing of OPA1.	ros	111-114	OPA1, mitochondrial dynamin like GTPase	Rattus norvegicus	312-316
27900598-11	2017	Furthermore, extensive oxidative stress induced by CS2 was also revealed by the measurement of ROS, RNS, MDA, GSH&amp;GSSG and antioxidant enzymes (CAT, T-SOD, and GSH-Px).	ros	95-98	calsyntenin 2	Rattus norvegicus	51-54
28011270-0	2017	H2S inhibits angiotensin II-induced atrial Kv1.5 upregulation by attenuating Nox4-mediated ROS generation during atrial fibrillation.	ros	91-94	NADPH oxidase 4	Rattus norvegicus	77-81
28893092-6	2017	A total of 3[Formula: see text][Formula: see text]M SAA reduced migration distances from 262.2[Formula: see text][Formula: see text]m to 198.4[Formula: see text][Formula: see text]m at 24[Formula: see text]h and 344.8[Formula: see text][Formula: see text]m to 109.3[Formula: see text][Formula: see text]m at 48[Formula: see text]h. It was observed that the production of ROS in cells was significantly reduced by the treatment of 3[Formula: see text][Formula: see text]M SAA.	ros	371-374	serum amyloid A1 cluster	Homo sapiens	52-55
28893092-10	2017	Based on these results, our study indicated that SAA treatment can protect HPAECs from endoMT induced by hypoxia, which may perform via the inhibition on ROS production and further through the downstream effectors of BMPRs or TGF[Formula: see text]R including Smads, ERK and ROCK/cofilin pathways.	ros	154-157	serum amyloid A1 cluster	Homo sapiens	49-52
29225212-4	2017	In this study, we found that treatment of cells with an iron-specific chelator deferoxamine (DFO) increased reactive oxidative species (ROS) production by elevating the expression of p47phox and p67phox compared with that in untreated cells.	ros	136-139	neutrophil cytosolic factor 1	Homo sapiens	183-190
29250536-0	2017	Transient Receptor Potential Melastatin 2 Negatively Regulates LPS-ATP-Induced Caspase-1-Dependent Pyroptosis of Bone Marrow-Derived Macrophage by Modulating ROS Production.	ros	158-161	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	0-41
29250536-10	2017	Conclusion: Deletion of TRPM2 can enhance the activation of caspase-1 and pyroptosis, which may be via modulating ROS production, suggesting that TRPM2 plays a critical role in immune adjustment.	ros	114-117	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	24-29
29250536-10	2017	Conclusion: Deletion of TRPM2 can enhance the activation of caspase-1 and pyroptosis, which may be via modulating ROS production, suggesting that TRPM2 plays a critical role in immune adjustment.	ros	114-117	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	146-151
26631910-5	2017	IFNgamma induced mitochondrial co-localization of RIG-I was concomitant with its ability to regulate ROS generation, oxidative phosphorylation (OXPHOS) and key enzymes involved in glycolysis and pentose phosphate pathway.	ros	101-104	DExD/H-box helicase 58	Homo sapiens	50-55
28592114-10	2017	However, pretreatment with N-acetyl- L-cysteine (NAC), a ROS scavenger, increased the expression of procaspase-3.	ros	57-60	X-linked Kx blood group	Homo sapiens	49-52
29410737-3	2017	Recently, inhibition of the NADPH oxidase (NOX2) was reported to protect against oxidative stress (ROS) production.	ros	99-102	cytochrome b-245 beta chain	Rattus norvegicus	43-47
29430285-9	2017	Higher concentrations of AGEs induced intracellular ROS and 4-HNE, which were associated with activation of the NF-kappaB pathway and caspase-3.	ros	52-55	caspase 3	Mus musculus	134-143
27924062-5	2016	Mechanistically, CDCA triggered ROS formation in part through TGR5/EGFR downstream signaling, including protein kinase B, extracellular regulated protein kinases and c-Jun N-terminal kinase pathways.	ros	32-35	G protein-coupled bile acid receptor 1	Mus musculus	62-66
27942584-10	2016	IFN-epsilon induced significant phagocytosis and ROS, which contributed to the block to HIV replication.	ros	49-52	interferon epsilon	Homo sapiens	0-11
27881869-5	2016	The Inalpha6beta4 signaling of Ntn-1 through ROS production is uniquely mediated by the activation of SP1 for cell cycle progression and the transcriptional occupancy of SP1 on the VEGF promoter.	ros	45-48	vascular endothelial growth factor A	Mus musculus	181-185
27861612-8	2016	Suppressing CLIC1 expression through gene knocked-out (CLIC1-/-) or using the specific inhibitor indanyloxyacetic acid-94 (IAA94) reduced ROS production, increased SOD enzyme activity, and significantly decreased MDA level.	ros	138-141	chloride intracellular channel 1	Homo sapiens	12-17
27861612-8	2016	Suppressing CLIC1 expression through gene knocked-out (CLIC1-/-) or using the specific inhibitor indanyloxyacetic acid-94 (IAA94) reduced ROS production, increased SOD enzyme activity, and significantly decreased MDA level.	ros	138-141	chloride intracellular channel 1	Homo sapiens	55-60
27816051-4	2016	RESULTS: HMA affects cellular morphology, alters mitochondrial structure and function, causes an increase in ROS, which is detrimental to DNA integrity, stimulates poly(ADP-ribose) synthesis, activates RIPK3-dependent death and triggers autophagy, which is unable to rescue cell survival.	ros	109-112	receptor interacting serine/threonine kinase 3	Homo sapiens	202-207
27798190-3	2016	Ca2+ release from the endoplasmic reticulum, mediated by both the IP3R1 and ryanodine receptor (RyR) channels, requires physiological ROS levels that are mainly sustained by the NADPH oxidase (NOX) complex.	ros	134-137	inositol 1,4,5-trisphosphate receptor, type 1	Rattus norvegicus	66-71
27318798-8	2016	In response to stress, the plants synthesized enzymatic free radicals (ROS) scavengers that lead to changes in the activity of superoxide dismutase (SOD) and catalase (CAT), as well as significantly increased peroxidase (POD) activity.	ros	71-74	prx7	Hordeum vulgare	209-219
27318798-8	2016	In response to stress, the plants synthesized enzymatic free radicals (ROS) scavengers that lead to changes in the activity of superoxide dismutase (SOD) and catalase (CAT), as well as significantly increased peroxidase (POD) activity.	ros	71-74	prx7	Hordeum vulgare	221-224
27021964-10	2016	Further, with the support of in vivo and in vitro studies, we discuss the putative molecular mechanisms underlying the ROS-mediated modulation of HSP expression and/or activity during exercise.	ros	119-122	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	146-149
27774407-1	2016	In this review, potential fluorescent probe applications for detecting reactive oxygen and nitrogen species (ROS/RNS) generated from NADPH oxidases (e.g., Nox2) and nitric oxide synthase enzymes are discussed in the context of pesticide toxicology.	ros	109-112	cytochrome b-245 beta chain	Homo sapiens	155-159
27317889-8	2016	We also demonstrated that aldosterone induced the phosphorylation of EGFR through generation of ROS.	ros	96-99	epidermal growth factor receptor	Rattus norvegicus	69-73
27317889-10	2016	Taken together, we concluded that aldosterone-mediated tissue fibrosis relies on ROS induced EGFR/ERK activation, highlighting EGFR as a potential therapeutic target for modulating renal fibrosis.	ros	81-84	epidermal growth factor receptor	Rattus norvegicus	93-97
27317889-10	2016	Taken together, we concluded that aldosterone-mediated tissue fibrosis relies on ROS induced EGFR/ERK activation, highlighting EGFR as a potential therapeutic target for modulating renal fibrosis.	ros	81-84	epidermal growth factor receptor	Rattus norvegicus	127-131
27292614-12	2016	Moreover, co-treatment with NAC (ROS scavenger), SB203580 (p38 inhibitor), SP600125 (JNK inhibitor) or salubrinal (ER stress inhibitor) significantly attenuated TBMS1-induced apoptosis.	ros	33-36	X-linked Kx blood group	Homo sapiens	28-31
27108344-5	2016	Meanwhile, the ROS scavenger N-acetyl-L-cysteine (NAC) and the Jnk inhibitor SP600125 were found to inhibit the MPPa-PDT-induced autophagy, and NAC could also inhibit Jnk phosphorylation.	ros	15-18	X-linked Kx blood group	Homo sapiens	50-53
27108344-5	2016	Meanwhile, the ROS scavenger N-acetyl-L-cysteine (NAC) and the Jnk inhibitor SP600125 were found to inhibit the MPPa-PDT-induced autophagy, and NAC could also inhibit Jnk phosphorylation.	ros	15-18	X-linked Kx blood group	Homo sapiens	144-147
26935109-13	2016	POMC-Ptp1b deletion increases plasma TNF-alpha levels, which contribute to body weight regulation via increased energy expenditure and impair endothelial function via COX-2 and ROS-dependent mechanisms.	ros	177-180	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	5-10
27081033-7	2016	DT-010 also promoted ROS generation, while treatment with ROS scavenger, NAC (N-acetyl-L-cysteine), reversed DT-010-induced cytotoxicity.	ros	58-61	X-linked Kx blood group	Homo sapiens	73-76
26700624-6	2016	We propose that SAHA causes ROS overproduction and mitochondrial dysfunction, which leads to HSP60 nitration and release into the intercellular space and circulation to interact with the immune system.	ros	28-31	heat shock protein family D (Hsp60) member 1	Homo sapiens	93-98
27347324-13	2016	Our results suggest that the RAGE activation by AGEs in EPCs upregulates intracellular ROS levels, which contributes to increased activity of NADPH oxidase and expression of Rac1, thus promoting cellular apoptosis and inhibiting proliferation.	ros	87-90	long intergenic non-protein coding RNA 914	Homo sapiens	29-33
27347324-13	2016	Our results suggest that the RAGE activation by AGEs in EPCs upregulates intracellular ROS levels, which contributes to increased activity of NADPH oxidase and expression of Rac1, thus promoting cellular apoptosis and inhibiting proliferation.	ros	87-90	2,4-dienoyl-CoA reductase 1	Homo sapiens	142-147
27347324-13	2016	Our results suggest that the RAGE activation by AGEs in EPCs upregulates intracellular ROS levels, which contributes to increased activity of NADPH oxidase and expression of Rac1, thus promoting cellular apoptosis and inhibiting proliferation.	ros	87-90	Rac family small GTPase 1	Homo sapiens	174-178
27347324-14	2016	Mechanistically, AGEs binding to the receptor RAGE in EPCs is associated with hyperactivity of JNK signaling pathway, which is downstream of ROS.	ros	141-144	long intergenic non-protein coding RNA 914	Homo sapiens	46-50
27347324-15	2016	Our findings suggest that dysregulation of the AGEs/RAGE axis in EPCs may promote atherosclerosis and identify the NADPH/ROS/JNK signaling axis as a potential target for therapeutic intervention.	ros	121-124	2,4-dienoyl-CoA reductase 1	Homo sapiens	115-120
26895787-4	2016	We also show that deletion of AIF1 in hxk2Delta cells enhances survival after induction of apoptosis with both H2O2 and acetic acid, rescues the reduction of both growth rate and cell size, abrogates both H2O2 and acetic acid-induced ROS accumulation and decreases cell death, suggesting that Aif1 might be involved in both H2O2 and acetic acid-induced cell death in hxk2Delta cells.	ros	234-237	Aif1p	Saccharomyces cerevisiae S288C	30-34
26866938-5	2016	Downregulation of Prx II in Huh7 cells with treatment of siRNA reduced expression of EpCAM and CD133 as well as Sox2 in accordance with increased ROS and apoptosis, which were reversed in Huh7-hPrx II cells.	ros	146-149	MIR7-3 host gene	Homo sapiens	28-32
26866938-5	2016	Downregulation of Prx II in Huh7 cells with treatment of siRNA reduced expression of EpCAM and CD133 as well as Sox2 in accordance with increased ROS and apoptosis, which were reversed in Huh7-hPrx II cells.	ros	146-149	MIR7-3 host gene	Homo sapiens	188-192
26854718-8	2016	Further, inhibition of ROS with NAC not only rescued glioma cell necrosis but also suppressed JNK activation, mitigated Bax/Bcl-2 ratio, maintained mitochondrial membrane potential, and inhibited AIF translocation into nucleus.	ros	23-26	BCL2-associated X protein	Mus musculus	120-123
26854718-8	2016	Further, inhibition of ROS with NAC not only rescued glioma cell necrosis but also suppressed JNK activation, mitigated Bax/Bcl-2 ratio, maintained mitochondrial membrane potential, and inhibited AIF translocation into nucleus.	ros	23-26	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	196-199
26953552-0	2016	Silencing of USP22 suppresses high glucose-induced apoptosis, ROS production and inflammation in podocytes.	ros	62-65	ubiquitin specific peptidase 22	Rattus norvegicus	13-18
26953552-6	2016	Silencing of USP22 in podocytes attenuated high d-glucose-induced apoptosis and inflammatory responses, evidenced by increases in proliferation and MMP levels and decreases in the apoptotic rate, ROS production, the Bax/Bcl-2 ratio, caspase-3 expression and secretion of TNF-alpha, IL-1beta, IL-6 and TGF-beta1.	ros	196-199	ubiquitin specific peptidase 22	Rattus norvegicus	13-18
27064409-6	2016	The ROS damage is slightly reduced and the mitochondrial unfolded protein response pathway is weakly activated in miro-1 mutants.	ros	4-7	Mitochondrial Rho GTPase 1	Caenorhabditis elegans	114-120
26723502-4	2016	Combined treatment of high NaCl (0.15M) with sub-effective IL-17 (0.1 nM) induced enhanced growth in breast cancer cells along with activation of reactive nitrogen and oxygen (RNS/ROS) species known to promote cancer.	ros	180-183	interleukin 17A	Homo sapiens	59-64
26860957-7	2016	Pretreatment of antioxidants caused decrease in the levels of ROS/RNS leads to an increase in the levels of antioxidants, decrease in biomolecules damage, alterations in Akt, ERK1/2, tuberin, upregulation of OGG1, and decrease in 8-OHdG accumulations in DNA.	ros	62-65	8-oxoguanine DNA-glycosylase 1	Mus musculus	208-212
26548866-0	2016	Critical role of miR-155/FoxO1/ROS axis in the regulation of non-small cell lung carcinomas.	ros	31-34	microRNA 155	Homo sapiens	17-24
26548866-12	2016	In conclusion, we found that miR-155 promoted NSCLC cell proliferation through inhibition of FoxO1 and the subsequent increase of ROS generation.	ros	130-133	microRNA 155	Homo sapiens	29-36
26548866-13	2016	Our findings highlight miR-155/FoxO1/ROS axis as a novel therapeutic target for the inhibition of NSCLC growth.	ros	37-40	microRNA 155	Homo sapiens	23-30
27065868-12	2016	In the S1P-treated mice, we found that the levels of ICAM-1 protein and mRNA in the lung fractions, the pulmonary hematoma and leukocyte count in bronchoalveolar lavage fluid were enhanced through a PKCdelta/PYK2/NADPH oxidase/ROS/NF-kappaB signaling pathway.	ros	227-230	protein kinase C, delta	Mus musculus	199-207
26403856-5	2016	RESULTS: The study revealed elevated levels of chaperones like HSP70, protein disulfide isomerase; oxidative stress proteins like peroxiredoxin2 and superoxide dismutase1 along with high ROS levels.	ros	187-190	heat shock protein family A (Hsp70) member 4	Homo sapiens	63-97
26683770-6	2016	Further, antioxidant NAC, as well as PARP-1 inhibitor 3AB, not only alleviated the overproduction of ROS caused by DPT, but also reversed the above-mentioned biochemical events, maintained mitochondrial membrane potential and rescued glioma cells death.	ros	101-104	NLR family, pyrin domain containing 1A	Mus musculus	21-24
26683770-6	2016	Further, antioxidant NAC, as well as PARP-1 inhibitor 3AB, not only alleviated the overproduction of ROS caused by DPT, but also reversed the above-mentioned biochemical events, maintained mitochondrial membrane potential and rescued glioma cells death.	ros	101-104	poly (ADP-ribose) polymerase family, member 1	Mus musculus	37-43
26804764-0	2016	4-Nonylphenol induces apoptosis, autophagy and necrosis in Sertoli cells: Involvement of ROS-mediated AMPK/AKT-mTOR and JNK pathways.	ros	89-92	mechanistic target of rapamycin kinase	Rattus norvegicus	111-115
26804764-11	2016	Collectively, our findings provide the first evidence that NP promotes apoptosis, autophagy and necrosis simultaneously in SCs and that this process may involve ROS-dependent JNK- and Akt/AMPK/mTOR pathways.	ros	161-164	mechanistic target of rapamycin kinase	Rattus norvegicus	193-197
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	ros	56-59	mitogen-activated protein kinase 8	Mus musculus	60-63
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	ros	177-180	mitogen-activated protein kinase 8	Mus musculus	60-63
26548719-9	2016	CoQ0-induced Nrf2 activation appears to be regulated by ROS-JNK-signaling cascades, as evidenced by suppressed Nrf2 activation upon treatment with pharmacological inhibitors of ROS (N-acetylcysteine) and JNK (SP600125).	ros	177-180	mitogen-activated protein kinase 8	Mus musculus	204-207
26718128-0	2016	Hispolon inhibits breast cancer cell migration by reversal of epithelial-to-mesenchymal transition via suppressing the ROS/ERK/Slug/E-cadherin pathway.	ros	119-122	snail family transcriptional repressor 2	Homo sapiens	127-131
26718128-6	2016	Taken together, our results indicated that hispolon suppressed the migration of breast cancer cells via suppressing the ROS/ERK/Slug/E-cadherin pathway.	ros	120-123	snail family transcriptional repressor 2	Homo sapiens	128-132
26724859-4	2016	NANOG represses mitochondrial oxidative phosphorylation (OXPHOS) genes, as well as ROS generation, and activates fatty acid oxidation (FAO) to support TIC self-renewal and drug resistance.	ros	83-86	Nanog homeobox	Homo sapiens	0-5
27563337-3	2016	IRE1-JNK and eIF2alpha-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors.	ros	118-121	eukaryotic translation initiation factor 2A	Homo sapiens	13-22
27766610-13	2016	In GC2 cells, knockdown of Sucla2 decreased cell viability and MMP, induced apoptosis of GC2 cells, decreased ATP production, and Bcl2 expression, and increased ROS levels.	ros	161-164	succinate-Coenzyme A ligase, ADP-forming, beta subunit	Mus musculus	27-33
27050175-2	2016	It is based on evidence that a continuous long-term exposure to oral bacteremia and bacterial toxins induces inflammatory immune response after immune evasion releases growth factors such as FGF, EGF, TGF-Beta, free radicals such as ROS and NOS, cytokines such as TNFAlfa, IL-1 Beta, IL-6; and matrix metalloproteinase such as MMP-9.	ros	233-236	matrix metallopeptidase 9	Homo sapiens	327-332
26111538-6	2016	Coincidently, both superoxide formation and ERK1/2 phosphorylation were observed in Met-5A cells exposed to MWCNTs and were diminished by pretreatment with the reactive oxidative species (ROS) scavenger, N-acetyl-l-(+)-cysteine (NAC).	ros	188-191	X-linked Kx blood group	Homo sapiens	229-232
26512059-6	2016	Physiological and biochemical analyses indicated that MLP43 functioned as a positive regulator in ABA- and drought-stress responses in Arabidopsis through regulating water loss efficiency, electrolyte leakage, ROS levels, and as well as ABA-responsive gene expression.	ros	210-213	MLP-like protein 43	Arabidopsis thaliana	54-59
26606859-9	2016	KEY FINDINGS: Dexamethasone (0.1 muM) treatment induced INS-1 apoptosis, which was associated with increased GSK-3beta activation and increased NOX4-derived ROS generation.	ros	157-160	NADPH oxidase 4	Rattus norvegicus	144-148
27525052-6	2016	In addition, we observed that MeHg induced ROS production in a dose-dependent manner in hNPCs cells, which was associated with significantly increased expressions of ND1, Cytb, and ATP6.	ros	43-46	mitochondrially encoded cytochrome b	Homo sapiens	171-175
27843533-8	2016	These results showed that NPOA treatment sensitizes H1299 cells towards CPT-induced accumulation of cell cycle S phase and mitochondrial-mediated apoptosis through regulating endogenous ROS and JNK activation.	ros	186-189	choline phosphotransferase 1	Homo sapiens	72-75
28132465-5	2016	In other organisms AOX activity is important for maintaining metabolic homeostasis (carbon metabolism, cell redox state and energy demand) and ROS homeostasis.	ros	143-146	acyl-CoA oxidase 1	Homo sapiens	19-22
26862579-4	2016	Ang II also stimulates ROS production in VSMC via p47 (phox) , a NOX2 subunit.	ros	23-26	cytochrome b-245 beta chain	Homo sapiens	65-69
26432358-6	2015	In conclusion, Estrogen suppresses breast cancer growth by inhibiting G1/S phase transition through GPER/ROS/p38 MAPK/p21 mediated signaling during hypoxic condition.	ros	105-108	G protein-coupled estrogen receptor 1	Homo sapiens	100-104
25975898-3	2015	The regulation of ROS/RNS is largely attended by peroxiredoxins (Prdxs) and their main reductants, thioredoxins (Trxs).	ros	18-21	thioredoxin 1	Mus musculus	99-111
26416307-3	2015	In the present study, blocking of SOD and catalase in TLR-2 neutralized fresh bone marrow cells (FBMC) with Diethyldithiocarbamic acid (DDC) and 3-Amino-1,2,4-triazole (ATZ), separately, during acute S. aureus infection, produces moderate level of ROS and limits inflammation as compared with only TLR-2 non-neutralized condition and leads to decreased bacterial count compared with only TLR-2 neutralized condition.	ros	248-251	AT695_RS10915	Staphylococcus aureus	34-50
26416307-4	2015	In summary, host SOD and catalase modulates ROS generation, cytokine levels and TLR-2 expression in FBMCs during acute S. aureus infection which might be useful in the alleviation of S. aureus infection and bone loss.	ros	44-47	AT695_RS10915	Staphylococcus aureus	25-33
26536834-9	2015	Intracellular and extracellular reactive oxidative species (ROS) production was significantly increased in the animals treated with native LDL, or ox-LDL and in hyperlipidemic LDL receptor knockout (LDLR(-/-)) mice that was effectively prevented with NAC treatment.	ros	60-63	low density lipoprotein receptor	Mus musculus	176-188
26536834-9	2015	Intracellular and extracellular reactive oxidative species (ROS) production was significantly increased in the animals treated with native LDL, or ox-LDL and in hyperlipidemic LDL receptor knockout (LDLR(-/-)) mice that was effectively prevented with NAC treatment.	ros	60-63	low density lipoprotein receptor	Mus musculus	199-203
26359950-8	2015	KEY RESULTS: S1P stimulated mTOR activation through the Nox2/ROS and PI3K/Akt pathways, which can further stimulate FoxO1 phosphorylation and translocation to the cytosol.	ros	61-64	cytochrome b-245 beta chain	Homo sapiens	56-60
26455407-5	2015	ROS accumulation was completely counteracted by the ROS scavenger, N-acetyl-l-cysteine (NAC).	ros	0-3	X-linked Kx blood group	Homo sapiens	88-91
26455407-5	2015	ROS accumulation was completely counteracted by the ROS scavenger, N-acetyl-l-cysteine (NAC).	ros	52-55	X-linked Kx blood group	Homo sapiens	88-91
26455407-6	2015	Apoptotic cell death appeared directly correlated to ROS production since NAC was able to counteract this effect.	ros	53-56	X-linked Kx blood group	Homo sapiens	74-77
26385178-6	2015	Aberrant activation of SHP2 by ROS was specifically shown in PC14PE6/AS2 cells and PTEN-deficient A549 cells.	ros	31-34	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	23-27
26385178-8	2015	These results demonstrate that a decrease in PTEN facilitates ROS/SHP2 signaling, causing lung cancer cells to become unresponsive to IFN-gamma.	ros	62-65	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	66-70
26475437-7	2015	ROS-expressing tumors were associated with better disease-free survival (30.1 months for ROS1 expression (+) tumors vs. 9.0 months for ROS1 (-) tumors, p = 0.006).	ros	0-3	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	89-93
26475437-7	2015	ROS-expressing tumors were associated with better disease-free survival (30.1 months for ROS1 expression (+) tumors vs. 9.0 months for ROS1 (-) tumors, p = 0.006).	ros	0-3	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	135-139
25998538-10	2015	Furthermore, application of alphaB-crystallin/HSPB5 to isolated rat brain mitochondria inhibits ROS generation induced by complex III inhibition with Antimycin A.	ros	96-99	crystallin alpha B	Homo sapiens	46-51
24395385-6	2015	In estrogen (E2)-treated CaOV-3 cells, elevated p66Shc protein level correlates with ROS level, ErbB-2 and ERK/MAPK activation, and cell proliferation.	ros	85-88	src homology 2 domain-containing transforming protein C1	Mus musculus	48-54
26033363-12	2015	Downstream activation of NFkappaB and rate of generation of ROS was also decreased on gene silencing of TLR4 and exposure to anti-HMGB1.	ros	60-63	high mobility group box 1	Rattus norvegicus	130-135
25727400-3	2015	The ALK/c-MET/ROS inhibitor crizotinib successfully improved the treatment of ALK-driven diseases.	ros	14-17	ALK receptor tyrosine kinase	Homo sapiens	78-81
25964188-7	2015	N-acetyl-l-cysteine (NAC), a ROS scavenger, could reverse SC-III3-caused ROS accumulation, but it did not affect SC-III3-induced autophagy, suggesting that ROS was not involved in SC-III3-mediated autophagy in HepG2 cells.	ros	29-32	X-linked Kx blood group	Homo sapiens	21-24
25964188-7	2015	N-acetyl-l-cysteine (NAC), a ROS scavenger, could reverse SC-III3-caused ROS accumulation, but it did not affect SC-III3-induced autophagy, suggesting that ROS was not involved in SC-III3-mediated autophagy in HepG2 cells.	ros	73-76	X-linked Kx blood group	Homo sapiens	21-24
25964188-7	2015	N-acetyl-l-cysteine (NAC), a ROS scavenger, could reverse SC-III3-caused ROS accumulation, but it did not affect SC-III3-induced autophagy, suggesting that ROS was not involved in SC-III3-mediated autophagy in HepG2 cells.	ros	73-76	X-linked Kx blood group	Homo sapiens	21-24
25849313-7	2015	Moreover, platelets added with specific inhibitors of Nox2 revealed impaired platelet activation, along with ROS down-production.	ros	109-112	cytochrome b-245 beta chain	Homo sapiens	54-58
25861953-12	2015	The attenuation of intracellular ROS level by N-acetyl-l-cysteine (NAC) preserved the integrity of mitochondrial membrane and rescued the cells from cell death.	ros	33-36	X-linked Kx blood group	Homo sapiens	67-70
25945832-4	2015	Drug-induced Trx1 (PX-12) and TrxR1 (Auranofin) inhibition disrupted redox homeostasis resulting in ROS-induced apoptosis in MM cells and a reduction in clonogenic activity.	ros	100-103	thioredoxin reductase 1	Homo sapiens	30-35
25683919-5	2015	GNF-2 and GNF-5 increased cell viability and attenuated STZ-induced intracellular ROS and significantly reduced the activation of JNK, caspase 3, and caspase 3-dependent activation of PKCdelta.	ros	82-85	growth and fatness 2	Mus musculus	0-5
25645596-3	2015	Furthermore, the induction of HO-1 and Hsp70 by solanesol could protect against ethanol-induced liver injury, including significantly suppressing the elevation of the activities of LDH and AST, attenuating ethanol-induced increase of the MDA, ROS level and decrease of the GSH level.	ros	243-246	heat shock protein family A (Hsp70) member 4	Homo sapiens	39-44
25714028-2	2015	p62 induced phase II detoxification enzyme NADPH quinone oxidoreductase 1 (NQO1), which decreased ROS levels and cell migration.	ros	98-101	sequestosome 1	Homo sapiens	0-3
25714028-7	2015	We conclude that miR-372 decreases p62, thus increasing ROS and motility in HNSCC cells.	ros	56-59	microRNA 372	Homo sapiens	17-24
25714028-7	2015	We conclude that miR-372 decreases p62, thus increasing ROS and motility in HNSCC cells.	ros	56-59	sequestosome 1	Homo sapiens	35-38
25890231-9	2015	Cell apoptosis here is induced by following the ROS-mediated mitochondrial pathway, combined with downregulation of the expression levels of mRNA of XIAP and PARP-1 and upregulation of caspase3, Bcl-2 and Bcl-xL.	ros	48-51	X-linked inhibitor of apoptosis	Homo sapiens	149-153
25683712-0	2015	HIGD1A Regulates Oxygen Consumption, ROS Production, and AMPK Activity during Glucose Deprivation to Modulate Cell Survival and Tumor Growth.	ros	37-40	HIG1 hypoxia inducible domain family member 1A	Homo sapiens	0-6
25477198-9	2015	CONCLUSION: Despite its known abilities to promote proliferation and DNA repair, and to reduce ROS, enrichment of FOXM1, as with other oncoproteins, may cause increased persistent DNA lesions and/or senescence in normal murine hepatocytes.	ros	95-98	forkhead box M1	Mus musculus	114-119
25772107-0	2015	SirT1 knockdown potentiates radiation-induced bystander effect through promoting c-Myc activity and thus facilitating ROS accumulation.	ros	118-121	sirtuin 1	Homo sapiens	0-5
25772107-4	2015	Meanwhile, SirT1 knockdown promoted transcriptional activity for c-Myc and facilitated ROS accumulation.	ros	87-90	sirtuin 1	Homo sapiens	11-16
25772107-5	2015	But both of the increased bystander responses and ROS generation due to SirT1-knockdown were almost completely suppressed by c-Myc interference.	ros	50-53	sirtuin 1	Homo sapiens	72-77
25772107-6	2015	Moreover, ROS scavenger effectively abolished the RIBE triggered by irradiated hepatoma cells even with SirT1 depletion.	ros	10-13	sirtuin 1	Homo sapiens	104-109
25772107-7	2015	These findings provide new insights that SirT1 has a profound role in regulating RIBE where a c-Myc-dependent release of ROS may be involved.	ros	121-124	sirtuin 1	Homo sapiens	41-46
25653619-3	2014	Using redox sensitive biosensors targeted to the mitochondria and NADPH oxidase (Nox2), we demonstrate that SMase increased Nox2-dependent ROS and had no effect on mitochondrial ROS in isolated FDB fibers.	ros	139-142	cytochrome b-245 beta chain	Homo sapiens	124-128
25653619-4	2014	Pharmacological inhibition and genetic knockdown of Nox2 activity prevented SMase induced ROS production and provided protection against decreased force production in the diaphragm.	ros	90-93	cytochrome b-245 beta chain	Homo sapiens	52-56
25389644-8	2015	Only xanthine dehydrogenase/oxidase showed a similar expression pattern across the three stress treatments, suggesting that reduction of ROS accumulation may be a conserved response to these stressors.	ros	137-140	xanthine dehydrogenase/oxidase	Crassostrea gigas	5-35
26089952-6	2015	High level of ROS was provoked by P2, which was in turn responsible for induction of apoptosis through activation of intrinsic mitochondrial pathway and JNK1/2, p38 MAPK pathways, as well as inhibition of ERK1/2 pathway, as evidenced by the abrogation of P2"s effect on HeLa cells preincubated with the ROS scavenger NAC.	ros	14-17	X-linked Kx blood group	Homo sapiens	317-320
25437876-7	2015	This alteration in the CD4+ T cell populations was mediated in part through ROS, as N-acetyl cysteine (NAC) treatment restored Th17 cell generation.	ros	76-79	CD4 antigen	Mus musculus	23-26
25325377-7	2015	The knockdown of CIP2A decreased the expression of LDH-A as well as the enzymatic activity, accompanying with a decreased lactate production, an increased NADH/NAD+ ratio and ROS production.	ros	175-178	cellular inhibitor of PP2A	Homo sapiens	17-22
25445985-13	2015	These results suggest that ROS and hormones regulating blood glucose metabolism play a role in ischemia/reperfusion-induced TIGAR upregulation.	ros	27-30	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	124-129
24986024-0	2015	ROS and p53 in regulation of UVB-induced HDM2 alternative splicing.	ros	0-3	MDM2 proto-oncogene	Homo sapiens	41-45
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	56-59	X-linked Kx blood group	Homo sapiens	101-104
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	56-59	MDM2 proto-oncogene	Homo sapiens	169-173
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	92-95	X-linked Kx blood group	Homo sapiens	101-104
24986024-7	2015	The less effectiveness could be due to the induction of ROS and p53 by UVB because removing ROS by L-NAC (10 mm) in p53 null cells could lead to alternative splicing of hdm2 upon UVB irradiation.	ros	92-95	MDM2 proto-oncogene	Homo sapiens	169-173
25346513-0	2014	DCT protects human melanocytic cells from UVR and ROS damage and increases cell viability.	ros	50-53	dopachrome tautomerase	Homo sapiens	0-3
25152235-0	2014	ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.	ros	0-3	spleen tyrosine kinase	Mus musculus	14-17
25152235-0	2014	ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation.	ros	0-3	signal transducer and activator of transcription 1	Homo sapiens	36-41
27308327-5	2014	HIPK2 integrates various signaling cues and senses different doses of DNA damage and ROS stimuli, which are reflected by unique patterns of HIPK2 modification.	ros	85-88	homeodomain interacting protein kinase 2	Homo sapiens	0-5
25550773-9	2014	HPC attenuated the oxidative stress by increasing the SOD activity and decreasing the MDA and ROS level, which were abolished by AMPK inhibition or eNOS inhibition.	ros	94-97	nitric oxide synthase 3	Rattus norvegicus	148-152
25037389-3	2014	In subsequent immunostimulatory studies, significantly enhanced ROS level, NO production and inflammatory cytokines secretion (IL-1beta, IL-6, and TNF-alpha) were observed in SEP-2 treated murine macrophage cell line RAW264.7.	ros	64-67	apolipoprotein A-I	Mus musculus	175-180
25264878-5	2014	Exposure to T-2 toxin can reduce activities of mitochondrial complexes III, IV and V, DeltaPsim and the cellular ATP, while intracellular ROS increased following treatment with T-2 toxin.	ros	138-141	solute carrier family 25 member 5	Homo sapiens	177-180
24902638-8	2014	A higher increase in ROS levels occurred in the early phase of AA-PCD in BRCA2-expressing yeast cells compared with non-expressing cells.	ros	21-24	BRCA2 DNA repair associated	Homo sapiens	73-78
24902638-9	2014	Accordingly, a delay in the initial burst of ROS levels was observed in BRCA2-knockdown anoikis-resistant human cells.	ros	45-48	BRCA2 DNA repair associated	Homo sapiens	72-77
25083993-2	2014	Here, we evaluated T cell populations from healthy volunteers and determined that human CD8+ effector memory T cells that reexpress the naive T cell marker CD45RA have many characteristics of cellular senescence, including decreased proliferation, defective mitochondrial function, and elevated levels of both ROS and p38 MAPK.	ros	310-313	CD8a molecule	Homo sapiens	88-91
24998607-5	2014	The inhibition of human osteoclast differentiation was associated with a down-regulation in RANKL-dependent intracellular ROS levels in human pre-osteoclasts cells.	ros	122-125	TNF superfamily member 11	Homo sapiens	92-97
25136835-14	2014	ROS inhibition markedly decreased nuclear factor-kB (NF-kB) phosphorylation, thioredoxin interacting/inhibiting protein (TXNIP), NLRP3 inflammasome, and mature IL-1beta in high glucose treated H9c2 cells.	ros	0-3	thioredoxin interacting protein	Rattus norvegicus	77-119
25136835-14	2014	ROS inhibition markedly decreased nuclear factor-kB (NF-kB) phosphorylation, thioredoxin interacting/inhibiting protein (TXNIP), NLRP3 inflammasome, and mature IL-1beta in high glucose treated H9c2 cells.	ros	0-3	thioredoxin interacting protein	Rattus norvegicus	121-126
25136835-18	2014	NF-kappaB and TXNIP mediated the ROS-induced caspase-1 and IL-1beta activation, which are the effectors of NLRP3 inflammasome.	ros	33-36	thioredoxin interacting protein	Rattus norvegicus	14-19
25136835-18	2014	NF-kappaB and TXNIP mediated the ROS-induced caspase-1 and IL-1beta activation, which are the effectors of NLRP3 inflammasome.	ros	33-36	caspase 1	Rattus norvegicus	45-54
25076856-8	2014	In conclusion, Lcn2 significantly inhibits HPASMC apoptosis induced by oxidative stress via decreased intracellular ROS and elevated SODs.	ros	116-119	lipocalin 2	Homo sapiens	15-19
24550188-3	2014	We previously developed mice that overexpress p22phox in vascular smooth muscle, tg(sm/p22phox), which have increased vascular ROS production.	ros	127-130	cytochrome b-245, alpha polypeptide	Mus musculus	46-53
24550188-8	2014	Tg(sm/p22phox) mice displayed impaired spontaneous activity and increased mitochondrial ROS production and mitochondrial dysfunction in skeletal muscle.	ros	88-91	cytochrome b-245, alpha polypeptide	Mus musculus	6-13
24728843-3	2014	Interaction of FcgammaRIIIA with uncomplexed IgG1 or IVIg, or with bivalent anti-FcgammaRIII F(ab")2 dampened calcium responses, ROS production, endocytosis and phagocytosis, induced by heterologous activating receptors.	ros	129-132	Fc gamma receptor IIIa	Homo sapiens	15-27
24952591-4	2014	ATP synthase knockdown precipitated a burst of mitochondrial ROS production, followed by copy number depletion involving increased mitochondrial turnover, not dependent on the canonical autophagy machinery.	ros	61-64	ATP synthase, subunit G	Drosophila melanogaster	0-12
24402688-2	2014	Among the enzymes generating ROS formation NOX2, the catalytic core of NADPH oxidase (NOX), plays a prominent role as shown by the almost absent ROS production by platelets taken from patients with hereditary deficiency of NOX2.	ros	29-32	cytochrome b-245 beta chain	Homo sapiens	43-47
24402688-2	2014	Among the enzymes generating ROS formation NOX2, the catalytic core of NADPH oxidase (NOX), plays a prominent role as shown by the almost absent ROS production by platelets taken from patients with hereditary deficiency of NOX2.	ros	29-32	cytochrome b-245 beta chain	Homo sapiens	223-227
24402688-2	2014	Among the enzymes generating ROS formation NOX2, the catalytic core of NADPH oxidase (NOX), plays a prominent role as shown by the almost absent ROS production by platelets taken from patients with hereditary deficiency of NOX2.	ros	145-148	cytochrome b-245 beta chain	Homo sapiens	43-47
24402688-2	2014	Among the enzymes generating ROS formation NOX2, the catalytic core of NADPH oxidase (NOX), plays a prominent role as shown by the almost absent ROS production by platelets taken from patients with hereditary deficiency of NOX2.	ros	145-148	cytochrome b-245 beta chain	Homo sapiens	223-227
24402688-5	2014	Similarly, normal platelets added with NOX2 specific inhibitors disclosed impaired platelet activation along with ROS down-regulation.	ros	114-117	cytochrome b-245 beta chain	Homo sapiens	39-43
24068521-8	2014	ROS inhibitor NAC abrogated the inhibitory effect of Hispidulin on P13k/Akt signalling pathway and the proapoptotic effect in HepG2 cells.	ros	0-3	X-linked Kx blood group	Homo sapiens	14-17
24415791-0	2014	Hv1 proton channels differentially regulate the pH of neutrophil and macrophage phagosomes by sustaining the production of phagosomal ROS that inhibit the delivery of vacuolar ATPases.	ros	134-137	hepatitis virus (MHV-2) susceptibility	Mus musculus	0-3
24415791-2	2014	Hv1 proton channels sustain ROS production at the plasma membrane, but their role in phagosomes is not known.	ros	28-31	hepatitis virus (MHV-2) susceptibility	Mus musculus	0-3
24415791-3	2014	Here, we tested whether Hv1 channels regulate the pHp and sustain phagosomal ROS production in neutrophils and macrophages.	ros	77-80	hepatitis virus (MHV-2) susceptibility	Mus musculus	24-27
24440036-6	2014	Mechanistically, the alh-6 mutation triggers diet-induced mitochondrial defects and increased generation of ROS, likely due to accumulation of its substrate 1-pyrroline-5-carboxylate.	ros	108-111	Aldedh domain-containing protein;L-glutamate gamma-semialdehyde dehydrogenase	Caenorhabditis elegans	21-26
24296130-6	2014	Moreover, genipin increased production of the ROS and the ROS-producing NAPDH-oxidase (NOX) family oxidases, NOX2 and NOX3.	ros	58-61	NADPH oxidase 3	Mus musculus	118-122
25162007-9	2014	RESULTS AND CONCLUSION: In vitro, with application of specific inhibitors and siRNA, AND-induced apoptosis was proven through ROS-ERK-P53-caspase 7-PARP signaling pathway.	ros	126-129	poly (ADP-ribose) polymerase family, member 1	Mus musculus	148-152
24616552-5	2014	Here, we reported that TNF-alpha-induced cPLA2 expression was mediated through TNFR1/PKCalpha-dependent signaling pathways, including NADPH oxidase (NOX) activation/ROS production and NF-kappaB activation.	ros	165-168	phospholipase A2 group IVA	Homo sapiens	41-46
25028602-5	2014	Our results clearly show that NAC administration depresses the expression of manganese superoxide dismutase (MnSOD) and TP53-induced glycolysis and apoptosis regulator (TIGAR), both of which play a predominant antioxidant role in mitochondria by reducing ROS level.	ros	255-258	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	120-167
25028602-5	2014	Our results clearly show that NAC administration depresses the expression of manganese superoxide dismutase (MnSOD) and TP53-induced glycolysis and apoptosis regulator (TIGAR), both of which play a predominant antioxidant role in mitochondria by reducing ROS level.	ros	255-258	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	169-174
25028602-7	2014	Collectively, our findings indicate that ROS is required for skeletal muscle constitutive autophagy, rather than starvation-induced autophagy, and that antioxidant NAC inhibits constitutive autophagy by the regulation of mitochondrial ROS production and antioxidant capacity.	ros	235-238	NLR family, pyrin domain containing 1A	Mus musculus	164-167
24055463-6	2013	Both Gr-1(+) and CD11b(+) cells in WSN virus-infected lungs produced reactive oxygen and nitrogen species (ROS/RNS).	ros	107-110	integrin subunit alpha M	Homo sapiens	17-22
24391542-8	2013	In addition, our data and that from other groups suggest that signaling through the NMDA receptor/PKC/NOX2 cascade generates ROS that activate the PI3/mTOR pathway and finally leads to the generation of new oligodendrocytes.	ros	125-128	cytochrome b-245 beta chain	Homo sapiens	102-106
24120900-8	2013	NAp reduced tissue damage and frequency of chromosomal aberrations, increased ROS accumulation to mediate mitochondrial-apoptosis through modulation of several apoptotic markers and mitochondrial matrix swelling.	ros	78-81	catenin, beta like 1	Mus musculus	0-3
23732520-4	2013	Consequently, cellular ROS is elevated, leading to the activation of FOXO3a, which contributes to Bim upregulation in Bax/Bak-deficient cells.	ros	23-26	BCL2 antagonist/killer 1	Homo sapiens	122-125
23856293-6	2013	MTR-3 cells with silencing of SIRT3 expression showed increases in the mitochondrial content of ERbeta, ROS level and apoptosis.	ros	104-107	exosome component 6	Homo sapiens	0-5
23816832-5	2013	Pretreatments with caspase-3 (z-DEVD-fmk) and AMPK (CC) inhibitors significantly suppressed the gammaT3-induced ROS production and cell death.	ros	112-115	caspase 3	Mus musculus	19-28
23831944-2	2013	NAD(P)H:quinone oxidoreductase 1 (NQO1) is well known to regulate ROS generation.	ros	66-69	NAD(P)H dehydrogenase, quinone 1	Mus musculus	0-32
23831944-2	2013	NAD(P)H:quinone oxidoreductase 1 (NQO1) is well known to regulate ROS generation.	ros	66-69	NAD(P)H dehydrogenase, quinone 1	Mus musculus	34-38
23831944-3	2013	The purpose of this study was to investigate whether NQO1 modulates cisplatin-induced renal failure associated with NADPH oxidase (NOX)-derived ROS production in an animal model.	ros	144-147	NAD(P)H dehydrogenase, quinone 1	Mus musculus	53-57
23931758-0	2013	Loss of cytochrome c oxidase promotes RAS-dependent ROS production from the ER resident NADPH oxidase, Yno1p, in yeast.	ros	52-55	putative metalloreductase	Saccharomyces cerevisiae S288C	103-108
23576041-8	2013	The antioxidant capacity of SIP18p was illustrated by ROS accumulation reduction after H2 O2 attack.	ros	54-57	Sip18p	Saccharomyces cerevisiae S288C	28-34
22429830-7	2013	When combined, ZEN and T-2 toxin increased ROS production and heat shock protein (Hsp) 70 expression as compared to the effect of each mycotoxin taken alone.	ros	43-46	solute carrier family 25 member 5	Homo sapiens	23-26
23799024-6	2013	The protective effects of GDF15 were probably achieved by inhibiting ROS overproduction in high glucose-treated human umbilical vein endothelial cells in a negative feedback manner.	ros	69-72	growth differentiation factor 15	Homo sapiens	26-31
23726973-3	2013	The functions of TIGAR were dispensable for normal growth and development in mice but played a key role in allowing intestinal regeneration in vivo and in ex vivo cultures, where growth defects due to lack of TIGAR were rescued by ROS scavengers and nucleosides.	ros	231-234	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	17-22
23726973-3	2013	The functions of TIGAR were dispensable for normal growth and development in mice but played a key role in allowing intestinal regeneration in vivo and in ex vivo cultures, where growth defects due to lack of TIGAR were rescued by ROS scavengers and nucleosides.	ros	231-234	Trp53 induced glycolysis regulatory phosphatase	Mus musculus	209-214
23665120-0	2013	ROS production and NF-kappaB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.	ros	0-3	Rac family small GTPase 1	Homo sapiens	53-57
23665120-6	2013	Mechanistically, RAC1-driven ROS and NF-kappaB signaling mediate these processes.	ros	29-32	Rac family small GTPase 1	Homo sapiens	17-21
23665120-7	2013	Together, these data highlight that ROS production and NF-kappaB activation triggered by RAC1 are critical events in CRC initiation.	ros	36-39	Rac family small GTPase 1	Homo sapiens	89-93
23746969-3	2013	(2013) show that Rac1 activation is required for Wnt-driven Lgr5+ intestinal stem cell transformation through ROS production and NF-kB activation.	ros	110-113	Rac family small GTPase 1	Homo sapiens	17-21
23704907-7	2013	In addition to the known mechanism by which SHP modulates innate signaling, we identify a new role of fenofibrate-induced SHP on UCP2 induction, which is required for the suppression of inflammatory responses through modulation of mitochondrial ROS production.	ros	245-248	nuclear receptor subfamily 0, group B, member 2	Mus musculus	122-125
23671702-4	2013	TNF-alphainduced ICAM-1 expression, ROS production, and cell-cell adhesion were significantly attenuated by the pretreatment with antioxidants (DPI, APO, or NAC) and CURN, but not by CURH, as revealed by western blot analysis, RT-PCR, promoter assay, and ROS detection and adhesion assay.	ros	255-258	intercellular adhesion molecule 1	Homo sapiens	17-23
22336250-2	2013	We evaluated whether NOX2, the catalytic core of NADPH oxidase, the most important producer of reactive oxidant species (ROS), is implicated in impairing FMD.	ros	121-124	cytochrome b-245 beta chain	Homo sapiens	21-25
23390308-9	2013	These findings suggested that HIV-induced TC apoptosis was mediated through ROS generation in response to HIV-induced VDR methylation and associated activation of the RAS.	ros	76-79	vitamin D receptor	Homo sapiens	118-121
24961316-6	2013	These results indicate for the first time that ROS signaling through a cerebrovascular Nox2 NADPH oxidase may be important in initiating brain angiogenesis.	ros	47-50	cytochrome b-245 beta chain	Rattus norvegicus	87-91
22975787-9	2013	TRPM2 acts thereby as a negative feedback loop by interfering through membrane depolarization with ROS generation by NADPH oxidases.	ros	99-102	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	0-5
23313944-5	2013	Methemoglobin-mediated ROS generation in the external micro-environment to develop oxidative stress close to RBC membrane seems to be responsible for initiating and forming high order RBC aggregates through phosphatidyl-serine externalization.	ros	23-26	hemoglobin subunit gamma 2	Homo sapiens	0-13
23861715-7	2013	Administration of QSYQ could attenuate LAD-induced HF, and AngII-NOX2-ROS-MMPs pathway seemed to be the critical potential targets for QSYQ to reduce the remodeling.	ros	70-73	cytochrome b-245 beta chain	Rattus norvegicus	65-69
23665934-7	2013	BRCA1 knockdown (BRCA1-KD) cells by siRNA significantly induced cellular accumulation of ROS compared to control cells.	ros	89-92	BRCA1 DNA repair associated	Homo sapiens	0-5
23665934-7	2013	BRCA1 knockdown (BRCA1-KD) cells by siRNA significantly induced cellular accumulation of ROS compared to control cells.	ros	89-92	BRCA1 DNA repair associated	Homo sapiens	17-22
23665934-8	2013	In this setting, the addition of paraquat, TCDD, DMBA, 2OHE2 or 4OHE2 significantly augmented ROS generation in BRCA1-KD MCF10A cells.	ros	94-97	BRCA1 DNA repair associated	Homo sapiens	112-117
23665934-11	2013	These results imply that elevated level of ROS is correlated with increase of DNA damage in BRCA1 defective cells.	ros	43-46	BRCA1 DNA repair associated	Homo sapiens	92-97
23634236-6	2013	In this paper we briefly discuss the mitochondria-related mechanisms in Ngb"s neuroprotection, especially those involved in ATP production, ROS generation and scavenging, and mitochondria-mediated cell death signaling pathways.	ros	140-143	neuroglobin	Homo sapiens	72-75
23441212-7	2013	Furthermore, the inhibition of autophagy also stimulated ROS formation and scavenging of ROS by antioxidant NAC inhibited caspase-3 activity, prevented the release of cyt-c from mitochondria and eventually rescued cancer cells from 5-FU-mediated apoptosis.	ros	89-92	X-linked Kx blood group	Homo sapiens	108-111
23272707-2	2012	NOX2, a cytochrome subunit of NOX, transports electrons across the plasma membrane to generate ROS, leading to physiological and pathological processes.	ros	95-98	cytochrome b-245 beta chain	Rattus norvegicus	0-4
23019230-8	2012	Experiments with cultured podocytes revealed previously unrecognized cross talk between p66 and the redox-sensitive transcription factor p53 that controls hyperglycemia-induced ROS metabolism, transcription of p53 target genes (angiotensinogen, angiotensin II type-1 receptor, and bax), angiotensin II generation, and apoptosis.	ros	177-180	src homology 2 domain-containing transforming protein C1	Mus musculus	88-91
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	12-15	BCL2-associated X protein	Mus musculus	224-227
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	12-15	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	279-282
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	BCL2-associated X protein	Mus musculus	224-227
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	279-282
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	BCL2-associated X protein	Mus musculus	224-227
23065091-6	2012	Blocking of ROS accumulation with ROS scavengers resulted in inhibition of celastrol-induced Bcl-2 family-mediated apoptosis, indicating that celastrol-induced apoptosis involves ROS generation as well as an increase in the Bax/Bcl-2 ratio leading to release of cytochrome c and AIF.	ros	34-37	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	279-282
22930452-8	2012	These data suggest that TCR-induced ROS generation from NOX2 activation can regulate the adaptive immune response in a T-cell-inherent fashion, and propose a possible role for redox signaling in T helper differentiation.	ros	36-39	cytochrome b-245 beta chain	Homo sapiens	56-60
22847064-6	2012	Employing a unique eukaryotic HSP60-overexpression method, we further demonstrated that extracellular HSP60 acts on microglial LOX-1 to boost the production of pro-inflammatory factors (IL-1beta, NO and ROS) in microglia and to propagate neuronal damage.	ros	203-206	heat shock protein family D (Hsp60) member 1	Homo sapiens	102-107
22895655-6	2012	Pretreatment with NAC slightly inhibited the expression levels of c-FLIPL             downregulated by the treatment of dioscin, suggesting that dioscin is partially             dependent on the generation of ROS for downregulation of c-FLIPL.	ros	209-212	X-linked Kx blood group	Homo sapiens	18-21
23117583-18	2012	Comparing bioluminescence in wildtype mice to p47(phox-/-) mice enables us to delineate the specific contribution of ROS generated by p47(phox)-containing NADPH oxidase to the bioluminescent signal in these models.	ros	117-120	cytochrome b-245 beta chain	Homo sapiens	138-142
23117583-19	2012	Bioluminescence imaging results that demonstrated increased ROS levels in wildtype mice compared to p47(phox-/-) mice indicated that NADPH oxidase is the major source of ROS generation in response to inflammatory stimuli.	ros	170-173	cytochrome b-245 beta chain	Homo sapiens	104-108
22991161-5	2012	The expression of HY1 is repressed in the athbp5 T-DNA knockdown mutant and the accumulation of H(2)O(2) is observed in athbp5 seedlings that are treated with methyl jasmonate (MeJA), a ROS-producing stress hormone.	ros	186-189	Plant heme oxygenase (decyclizing) family protein	Arabidopsis thaliana	18-21
23020852-3	2012	(2012) demonstrate that the telomeric protein TIN2 can specifically localize to the mitochondria, where it can regulate metabolism and ROS production.	ros	135-138	TERF1 interacting nuclear factor 2	Homo sapiens	46-50
22883108-12	2012	CONCLUSION: Overall, our data suggest that overexpression of GhWRKY15 may contribute to the alteration of defence resistance to both viral and fungal infections, probably through regulating the ROS system via multiple signalling pathways in tobacco.	ros	194-197	probable WRKY transcription factor 75	Gossypium hirsutum	61-69
22908045-9	2012	BIR1 deletion caused an increase level of ROS and mis-location of Bub1, a major protein for spindle assembly checkpoint.	ros	42-45	survivin	Saccharomyces cerevisiae S288C	0-4
22555451-5	2012	siRNA-mediated knockdown of CypB expression rendered hepatoma cells more vulnerable to ROS-mediated apoptosis.	ros	87-90	peptidylprolyl isomerase B	Homo sapiens	28-32
22812506-4	2012	Intracellular ROS levels were also measured and shown to increase significantly following exposure of the C3A to the low toxicity NMs (MWCNT and TiO(2)).	ros	14-17	complement C3	Homo sapiens	106-109
22562073-7	2012	Such inhibition of ROS prevented the processing and release of AIF (apoptosis-inducing factor) and HTRA2 from mitochondria.	ros	19-22	apoptosis inducing factor mitochondria associated 1	Homo sapiens	63-66
22562073-7	2012	Such inhibition of ROS prevented the processing and release of AIF (apoptosis-inducing factor) and HTRA2 from mitochondria.	ros	19-22	apoptosis inducing factor mitochondria associated 1	Homo sapiens	68-93
22525338-5	2012	During starvation, ROS-induced DNA damage activates PARP-1, leading to ATP depletion (an early event after nutrient deprivation).	ros	19-22	poly (ADP-ribose) polymerase family, member 1	Mus musculus	52-58
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	12-15	N-methylpurine DNA glycosylase	Homo sapiens	40-43
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	N-methylpurine DNA glycosylase	Homo sapiens	40-43
22652796-4	2012	Blockade of ROS by the ROS scavenger, 2-MPG, abolished cell invasion, inhibited the EMT process and decreased MMP-2 expression, suggesting ROS accumulation caused an increase in MMP-2 expression in BMP2-stimulated PANC-1 cell invasion.	ros	23-26	N-methylpurine DNA glycosylase	Homo sapiens	40-43
22350156-5	2012	The expressions of AtP5CS and AtZAT12 which mirror the activities of proline and ascorbate peroxidase synthesis respectively were induced in TaMYB33 over-expression lines, indicating TaMYB33 promotes the ability for osmotic pressure balance-reconstruction and reactive oxidative species (ROS) scavenging.	ros	288-291	delta1-pyrroline-5-carboxylate synthase 1	Arabidopsis thaliana	19-25
22708121-2	2012	ROS production is commonly involved in the pathogenesis of skin damage induced by these factors, causing skin aging, including wrinkling, by activating the metalloproteinases (MMP-1) that break down type I collagen (COL1A1).	ros	0-3	collagen type I alpha 1 chain	Homo sapiens	188-222
22127757-8	2012	PCB induced ROS may be linked to increased hippocampal neuronal apoptosis.	ros	12-15	pyruvate carboxylase	Rattus norvegicus	0-3
22137144-0	2012	Carnosine inhibits KRAS-mediated HCT116 proliferation by affecting ATP and ROS production.	ros	75-78	KRAS proto-oncogene, GTPase	Homo sapiens	19-23
22137144-3	2012	In this cell line, the activating KRAS mutation induces mitochondrial ROS, the signaling molecules for cell proliferation.	ros	70-73	KRAS proto-oncogene, GTPase	Homo sapiens	34-38
22001850-6	2012	By treatment of the cells with glycolysis inhibitors, an AMPK inhibitor or genetic knockdown of AMPK, respectively, the H(2)O(2)-induced increase of NADPH was abrogated leading to the overproduction of intracellular ROS and cell death.	ros	216-219	2,4-dienoyl-CoA reductase 1	Homo sapiens	149-154
22247972-12	2012	HO-1 overexpression decreased lipid peroxidation and inhibited the induction of ROS scavenging proteins.	ros	80-83	heme oxygenase 1	Rattus norvegicus	0-4
22100973-6	2012	Down-regulation of OGG-1 by siRNA lowered ROS and IL-4 levels but increased IFN-gamma production in cultured epithelial cells after exposure to house dust mite extracts.	ros	42-45	8-oxoguanine DNA-glycosylase 1	Mus musculus	19-24
22223094-0	2012	Brain and muscle ARNT-like protein BMAL1 regulates ROS homeostasis and senescence: a possible link to hypoxia-inducible factor-mediated pathway.	ros	51-54	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	35-40
22829775-3	2012	Using a panel of GFP-fused stress response genes, we identified the suites of cytoprotective pathways upregulated by 160 gene inactivations known to increase Caenorhabditis elegans longevity, including the mitochondrial UPR (hsp-6, hsp-60), the ER UPR (hsp-4), ROS response (sod-3, gst-4), and xenobiotic detoxification (gst-4).	ros	261-264	Endoplasmic reticulum chaperone BiP homolog;Heat shock 70 kDa protein D	Caenorhabditis elegans	253-258
22072715-8	2011	Thus, ligand-activated PPARdelta confers resistance to Ang II-induced senescence by up-regulation of PTEN and ensuing modulation of the PI3K/Akt signaling to reduce ROS generation in vascular cells.	ros	165-168	peroxisome proliferator activated receptor delta	Homo sapiens	23-32
21917631-9	2011	In addition to the normal activity of Mn-SOD, GPX and catalase detected an increased activity of complex II, and upregulation of UCP2 was observed in mitochondria from sucrose-fed rats, all of which may accelerate respiration rates and reduce generation of ROS.	ros	257-260	uncoupling protein 2	Rattus norvegicus	129-133
21820402-1	2011	Uncoupling protein 3 (UCP3) is implicated in mild uncoupling and the regulation of mitochondrial ROS production.	ros	97-100	uncoupling protein 3	Homo sapiens	0-20
21820402-1	2011	Uncoupling protein 3 (UCP3) is implicated in mild uncoupling and the regulation of mitochondrial ROS production.	ros	97-100	uncoupling protein 3	Homo sapiens	22-26
21852236-4	2011	Suppression of GPx-1 enhanced TNF-alpha-induced ROS production and ICAM-1 expression, whereas overexpression of GPx-1 attenuated these TNF-alpha-mediated responses.	ros	48-51	glutathione peroxidase 1	Homo sapiens	15-20
21852236-7	2011	To analyze further signaling pathways involved in GPx-1-mediated protection from TNF-alpha-induced ROS, we performed microarray analysis of human microvascular endothelial cells treated with TNF-alpha in the presence and absence of GPx-1.	ros	99-102	glutathione peroxidase 1	Homo sapiens	50-55
21712395-7	2011	The defect in NET formation in Rac2null cells was rescued by exogenous ROS sources, suggesting that Rac2-mediated ROS generation is required for NET formation.	ros	71-74	Rac family small GTPase 2	Mus musculus	31-35
21712395-7	2011	The defect in NET formation in Rac2null cells was rescued by exogenous ROS sources, suggesting that Rac2-mediated ROS generation is required for NET formation.	ros	71-74	Rac family small GTPase 2	Mus musculus	100-104
21712395-7	2011	The defect in NET formation in Rac2null cells was rescued by exogenous ROS sources, suggesting that Rac2-mediated ROS generation is required for NET formation.	ros	114-117	Rac family small GTPase 2	Mus musculus	31-35
21712395-7	2011	The defect in NET formation in Rac2null cells was rescued by exogenous ROS sources, suggesting that Rac2-mediated ROS generation is required for NET formation.	ros	114-117	Rac family small GTPase 2	Mus musculus	100-104
21712395-11	2011	Our data suggest that Rac2 is essential for NET formation via pathways involving ROS and NO.	ros	81-84	Rac family small GTPase 2	Mus musculus	22-26
21499310-4	2011	The effects of LXA(4), ANXA1, SAA and LL-37 were dependent on the activation of their mutual cell-surface receptor formyl peptide receptor-2 (FPR2) and subsequent ROS-MAPK-NF-kB signalings.	ros	163-166	serum amyloid A cluster	Mus musculus	30-33
21664494-3	2011	Both PINK1- and DJ-1-deficient dopaminergic neurons had the increased production of ROS, severe mitochondrial structural damages and complex I deficits.	ros	84-87	PTEN induced kinase 1	Homo sapiens	5-10
21788490-5	2011	Using a rat model of I/R, we show that circulating levels of TNF-alpha and cardiac caspase-8 activity were increased within 6 h of reperfusion, leading to myocardial nitric oxide and mitochondrial ROS production.	ros	197-200	caspase 8	Rattus norvegicus	83-92
21683690-0	2011	SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2.	ros	32-35	cytochrome b-245 beta chain	Homo sapiens	61-76
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	Rac family small GTPase 1	Homo sapiens	224-228
23554696-7	2011	Interestingly, EGF could induce a significant production of ROS, and N-acetyl-L-cysteine, a scavenger of ROS which abolished the EGF-induced ROS generation, cell migration, as well as activation of PI3K/Akt and PAK, but not Rac1.	ros	105-108	Rac family small GTPase 1	Homo sapiens	224-228
21600874-4	2011	This elevated level of apolipoprotein A-I was coupled with an elevated level of H-ras12V protein and ROS.	ros	101-104	apolipoprotein A-I	Mus musculus	23-41
21645446-14	2011	The ozonized saline, as a novel Nrf2 activator, can reduce the oxidative damage of radical oxygen species (ROS) and the deleterious substance by activating the Keap1-Nrf2-ARE signaling pathway and its downstream genes expression.	ros	107-110	Kelch-like ECH-associated protein 1	Rattus norvegicus	160-165
21316482-8	2011	Addition of the antioxidant N-acetyl-l-cysteine (NAC) markedly reduced the ROS level and partly suppressed the DNA strand breaks induced by BDE47 or/and BaP.	ros	75-78	X-linked Kx blood group	Homo sapiens	49-52
21194832-7	2011	Blockage of ROS by NAC or catalase inhibited the activation of NF-kappaB signaling and enhanced Rh2-induced cell death, suggesting that the anti-cancer effect of Rh2 can be enhanced by antioxidants.	ros	12-15	X-linked Kx blood group	Homo sapiens	19-22
21901141-6	2011	Furthermore, reduced matrigel invasion was mediated by reduced ROS levels coinciding with decreased expression of NADPH oxidase 2, 3, 4 and 5 involved in ROS production.	ros	154-157	cytochrome b-245 beta chain	Homo sapiens	114-141
20847053-6	2010	We sought to determine the effects of reactive oxygen and nitrogen species (ROS/RNS) on the assembly of TE into elastic fibers.	ros	76-79	elastin	Homo sapiens	104-106
20847053-10	2010	These findings establish that ROS/RNS can modify TE and that these modifications affect the assembly of elastic fibers.	ros	30-33	elastin	Homo sapiens	49-51
20685355-13	2010	Our findings suggest that the mechanisms of CAPE toxicity in SK-MEL-28 melanoma cells mediated by tyrosinase bioactivation of CAPE included quinone formation, ROS formation, intracellular GSH depletion and induced mitochondrial toxicity.	ros	159-162	tyrosinase	Homo sapiens	98-108
20482586-2	2010	H(2)O(2) and induced chemical species (e.g. polysulfide, ROS) and redox potential shift increased the expressions of the genes involved in detoxification, thioredoxin-dependent reduction system, protein and DNA repair, and decreased those involved in sulfate reduction, lactate oxidation and protein synthesis.	ros	57-60	DVU0378	Desulfovibrio vulgaris str. Hildenborough	155-166
20705126-6	2010	In mouse cardiac fibroblasts, bread crust extract induced a moderate elevation of ROS production causing an activation of p42/p44(MAPK), p38(MAPK) and NF-kappaB, followed by increased expression of antioxidative enzymes.	ros	82-85	interferon-induced protein 44	Mus musculus	126-129
20598695-11	2010	p21-overexpression significantly suppressed the DS-induced TXNIP expression, and inhibited the expression of vascular cell adhesion molecule 1 and chemokine (C-C motif) ligand 5 (CCL5/RANTES), which stimulates leukocyte recruitment and is downregulated by ROS scavenging.	ros	256-259	C-C motif chemokine ligand 5	Homo sapiens	179-183
20598695-11	2010	p21-overexpression significantly suppressed the DS-induced TXNIP expression, and inhibited the expression of vascular cell adhesion molecule 1 and chemokine (C-C motif) ligand 5 (CCL5/RANTES), which stimulates leukocyte recruitment and is downregulated by ROS scavenging.	ros	256-259	C-C motif chemokine ligand 5	Homo sapiens	184-190
20716293-5	2010	This prompts us to speculate that NADPH may act as a cofactor regulating ROS generation by mammalian catalases.	ros	73-76	2,4-dienoyl-CoA reductase 1	Homo sapiens	34-39
20716293-8	2010	Conformational changes following absorption of UVB light by catalase NADPH have the potential to facilitate ROS production by the enzyme.	ros	108-111	2,4-dienoyl-CoA reductase 1	Homo sapiens	69-74
20204677-5	2010	We found that TGF-beta1 activates NFkappaB, through Rac1-NOXs-ROS-dependent mechanism.	ros	62-65	Rac family small GTPase 1	Homo sapiens	52-56
20204677-6	2010	Our results shows that TGF-beta1 stimulation of uPA and MMP-9 expression involve NOXs-dependent ROS and NFkappaB, activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor.	ros	96-99	matrix metallopeptidase 9	Homo sapiens	56-61
20204677-6	2010	Our results shows that TGF-beta1 stimulation of uPA and MMP-9 expression involve NOXs-dependent ROS and NFkappaB, activation, demonstrated by using DPI, NOXs inhibitor, ROS scavenger N-acetylcysteine and SN50, an NFkb inhibitor.	ros	169-172	matrix metallopeptidase 9	Homo sapiens	56-61
20204677-8	2010	Thus, ROS-NFkappaB acts as the crucial signal in TGF-beta1-induced uPA and MMP-9 expression thereby mediating the enhancement of cellular malignity by TGF-beta1.	ros	6-9	matrix metallopeptidase 9	Homo sapiens	75-80
20154258-2	2010	Since both thromboxane-prostanoid receptor (TPr) signaling and ROS activate RhoA-Rho kinase (ROCK) in vascular smooth muscle (VSM) preparations, we hypothesized that enhanced endothelium-dependent contraction in the common carotid artery (CCA) of spontaneously hypertensive rats (SHRs) is ROCK mediated.	ros	63-66	ras homolog family member A	Rattus norvegicus	76-80
20154258-11	2010	These results indicate that RhoA-ROCK may act as a molecular switch, transducing signals from endothelium-derived prostaglandin(s) and ROS, which are overproduced in SHR CCAs, to "turn on" VSM contractile pathways, thus mediating the enhanced endothelium- and endoperoxide-dependent vascular contractions characteristic of hypertension, among other cardiovascular disease states, such as diabetes and aging.	ros	135-138	ras homolog family member A	Rattus norvegicus	28-32
20186747-9	2010	We identified the ATP-dependent protease Pim1/LON as a major factor in the degradation of ROS-modified soluble polypeptides localized in the matrix compartment.	ros	90-93	ATP-dependent Lon protease PIM1	Saccharomyces cerevisiae S288C	41-45
20186747-10	2010	As Pim1/LON expression was induced significantly under ROS treatment, we propose that this protease system performs a crucial protective function under oxidative stress conditions.	ros	55-58	ATP-dependent Lon protease PIM1	Saccharomyces cerevisiae S288C	3-7
20186753-6	2010	A beta and HA, but not the non-amyloidogenic rat amylin, induced significant increases in the generation of ROS.	ros	108-111	amyloid beta precursor protein	Rattus norvegicus	0-6
19879359-4	2010	Consequently, CA1 mitochondria exhibit stronger calcium accumulation, more extensive swelling and damage, stronger depolarization of their membrane potential, and a significant increase in ROS generation.	ros	189-192	carbonic anhydrase 1	Homo sapiens	14-17
20503474-4	2010	Pretreatment with ABO also blocked TNF-alpha-induced ROS formation.	ros	53-56	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	18-21
20503474-8	2010	Taken together, ABO could reduce cytokine-induced endothelial adhesiveness throughout down-regulating intracellular ROS production, NF-kappaB, and adhesion molecule expression in HUVEC, suggesting that the natural herb Buddleja officinalis may have potential implications in atherosclerosis.	ros	116-119	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	16-19
19768778-1	2010	A sequence derived from the epithelial receptor tyrosine kinase Ros (pY2267) represents a high-affinity binding partner for protein tyrosine phosphatase SHP-1 and was recently used as lead structure to analyze the recognition requirements for the enzyme"s N-SH2 domain.	ros	64-67	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	153-158
20414976-9	2010	RNAi silence of TRalpha1 or NOX1 abolished T3-induced intracellular ROS generation and PCNA and SM alpha-actin expression, indicating that TRalpha1 and NOX1 mediated T3-induced RASM cell proliferation.	ros	68-71	NADPH oxidase 1	Rattus norvegicus	28-32
20414976-9	2010	RNAi silence of TRalpha1 or NOX1 abolished T3-induced intracellular ROS generation and PCNA and SM alpha-actin expression, indicating that TRalpha1 and NOX1 mediated T3-induced RASM cell proliferation.	ros	68-71	NADPH oxidase 1	Rattus norvegicus	152-156
20631911-7	2010	Furthermore, Glycer-AGEs enhanced the migration capacity of the cells by activating Rac1 via ROS and also increased their invasion capacity.	ros	93-96	Rac family small GTPase 1	Homo sapiens	84-88
20360613-7	2010	Studies have shown that p38MAP kinase, nuclear factor kappaB (NF-kappaB), PKC/ERK and JNK/c-Jun all take part in the ROS-activated production of ET-1.	ros	117-120	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-95
19670268-2	2009	PLA(2) treatment induced an increase in intracellular Ca(2+) ([Ca(2+)]i) and ROS generation levels, leading to activation of p38 MAPK and JNK.	ros	77-80	phospholipase A2 group IIA	Homo sapiens	0-6
19615399-10	2009	Lack of IL-10 effect on ROS production was observed in older subjects (50-80 years old).	ros	24-27	interleukin 10	Homo sapiens	8-13
19615399-11	2009	The effect of IL-10 showed a significant inhibition of ROS production similar to those got with PD169316 alone as compared to that of p38 MAPK.	ros	55-58	interleukin 10	Homo sapiens	14-19
19615399-12	2009	CONCLUSION: The results suggest that inhibitory effect of the ROS production mediated by IL-10 depends on PKA for the younger and the lack effect on the elderly is p38 MAPK dependent.	ros	62-65	interleukin 10	Homo sapiens	89-94
19597524-2	2009	We hypothesized that dispersed NADPH oxidase, protein kinase Cepsilon (PKCepsilon), early response gene (ERG), and matrix metalloproteinase 9(MMP-9) across the heart by isoproterenol (ISO) medication might be mediated by the endothelin (ET) - ROS pathway.	ros	243-246	matrix metallopeptidase 9	Rattus norvegicus	142-147
19255257-4	2009	Under hypoxic conditions, BNIP3 also functions as a mediator of mitochondrial autophagy, a survival adaptation to control ROS production and DNA damage.	ros	122-125	BCL2 interacting protein 3	Rattus norvegicus	26-31
19358520-12	2009	In conclusion, our studies show that activation of TSPO by CoCl(2) application is required for ROS generation, leading to cardiolipin oxidation, and collapse of the Deltapsi(m), as induced by CoCl(2).	ros	95-98	translocator protein	Homo sapiens	51-55
19180563-4	2009	Upon exposure to PLA(2), ROS generation, p38 MAPK activation, and ERK inactivation were found in U937 cells.	ros	25-28	phospholipase A2 group IIA	Homo sapiens	17-23
19180563-5	2009	Abolition of PLA(2)-induced ROS generation abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored ERK activation and viability of PLA(2)-treated cells.	ros	28-31	phospholipase A2 group IIA	Homo sapiens	13-20
19180563-5	2009	Abolition of PLA(2)-induced ROS generation abrogated p38 MAPK activation and upregulation of Fas and FasL expression, but restored ERK activation and viability of PLA(2)-treated cells.	ros	28-31	phospholipase A2 group IIA	Homo sapiens	13-19
19180563-11	2009	Taken together, our results indicate that Fas/FasL upregulation in PLA(2)-treated U937 cells is elicited by ROS-mediated p38alpha MAPK activation and ERK inactivation, and suggest that autocrine Fas/FasL apoptotic mechanism is involved in PLA(2)-induced cell death.	ros	108-111	phospholipase A2 group IIA	Homo sapiens	67-73
19180563-11	2009	Taken together, our results indicate that Fas/FasL upregulation in PLA(2)-treated U937 cells is elicited by ROS-mediated p38alpha MAPK activation and ERK inactivation, and suggest that autocrine Fas/FasL apoptotic mechanism is involved in PLA(2)-induced cell death.	ros	108-111	phospholipase A2 group IIA	Homo sapiens	239-245
19261679-11	2009	Overall, our results demonstrate that the C191Y SDHB mutation suppresses SDH enzyme activity leading to increased ROS formation and mtDNA mutability in our yeast model.	ros	114-117	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	48-52
19261679-11	2009	Overall, our results demonstrate that the C191Y SDHB mutation suppresses SDH enzyme activity leading to increased ROS formation and mtDNA mutability in our yeast model.	ros	114-117	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	48-51
19323941-2	2009	Possible mechanisms underlying Abeta-induced neuronal cytotoxicity include excessive production of reactive oxidative species (ROS) and apoptosis.	ros	127-130	amyloid beta precursor protein	Rattus norvegicus	31-36
19323941-9	2009	In addition, rhCyPA attenuated Abeta(25-35)-induced overproduction of intracellular ROS and Abeta(25-35)-induced a decrease in activity of the key antioxidant enzymes SOD and GSH-Px.	ros	84-87	amyloid beta precursor protein	Rattus norvegicus	31-36
18804161-6	2008	Among the strains that accumulated greater amounts of glycogen, the deletion of glycogen phosphorylase, gph1delta, was unique in showing a shortened life span, stress intolerance, and higher levels of ROS during its survival.	ros	201-204	glycogen phosphorylase	Saccharomyces cerevisiae S288C	80-102
19649173-8	2008	This positive feedback mechanism for mPTP/ETC-dependent ROS generation may drive localized redox signaling in individual mitochondria under physiological conditions, and when left unchecked, contribute to global cellular oxidative stress under pathological conditions in cardiac disease.	ros	56-59	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	37-45
18946027-0	2008	Overexpressed cyclophilin B suppresses apoptosis associated with ROS and Ca2+ homeostasis after ER stress.	ros	65-68	peptidylprolyl isomerase B	Homo sapiens	14-27
18946027-4	2008	Overexpression of wild-type CypB attenuated ER stress-induced cell death, whereas overexpression of an isomerase activity-defective mutant, CypB/R62A, not only increased Ca(2+) leakage from the ER and ROS generation, but also decreased mitochondrial membrane potential, resulting in cell death following exposure to ER stress-inducing agents.	ros	201-204	peptidylprolyl isomerase B	Homo sapiens	140-144
18417276-3	2008	Engagement of B7-H4 initially increased intracellular level of ROS, which then induced the expression of FasL.	ros	63-66	V-set domain containing T cell activation inhibitor 1	Homo sapiens	14-19
18189268-5	2008	Pretreatment with NAC or GSH attenuated sanguinarine-induced apoptosis, suggesting the involvement of ROS in this cell death.	ros	102-105	X-linked Kx blood group	Homo sapiens	18-21
18385754-5	2008	Treatment of leukemia cell lines harboring wild-type or mutant Bcr-Abl with 10 microM PEITC resulted in an elevated ROS stress and a redox-mediated degradation of the BCR-ABL protein, leading to massive death of the leukemia cells.	ros	116-119	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	63-70
18385754-7	2008	We further showed that the ROS-induced degradation of BCR-ABL was mediated partially by caspase-3 and the proteasome pathway.	ros	27-30	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	54-61
18202321-5	2008	In addition, inhibiting ROS production stimulated by TS/IL-1beta decreased activation of Src, EGFR and p38MAPK, phosphorylation of PTEN, VE-cadherin and beta-catenin, and abrogated the effect of TS/IL-1beta to disorganize adherens junctions, resulting in reduced endothelial permeability and decreased nuclear beta-catenin accumulation.	ros	24-27	catenin (cadherin associated protein), beta 1	Mus musculus	153-165
18202321-5	2008	In addition, inhibiting ROS production stimulated by TS/IL-1beta decreased activation of Src, EGFR and p38MAPK, phosphorylation of PTEN, VE-cadherin and beta-catenin, and abrogated the effect of TS/IL-1beta to disorganize adherens junctions, resulting in reduced endothelial permeability and decreased nuclear beta-catenin accumulation.	ros	24-27	catenin (cadherin associated protein), beta 1	Mus musculus	310-322
18219386-2	2008	In this issue of the JCI, Harraz and colleagues demonstrate that SOD1 mutants expressed in human cell lines directly stimulate NADPH oxidase (Nox) by binding to Rac1, resulting in overproduction of damaging ROS (see the related article beginning on page 659).	ros	207-210	Rac family small GTPase 1	Homo sapiens	161-165
18551189-3	2008	Here, we report that mutations of MCD1 and PDS5, two major components of cohesin in budding yeast, cause apoptotic cell death, which is characterized by externalization of phosphatidylserine at cytoplasmic membrane, chromatin condensation and fragmentation, and ROS production.	ros	262-265	kleisin alpha	Saccharomyces cerevisiae S288C	34-38
17707342-1	2007	It has been reported that genipin, the aglycone of geniposide, induces apoptotic cell death in human hepatoma cells via a NADPH oxidase-reactive oxygen species (ROS)-c-Jun NH(2)-terminal kinase (JNK)-dependent activation of mitochondrial pathway.	ros	161-164	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	166-171
17707342-2	2007	This continuing work aimed to define that mixed lineage kinase 3 (MLK3) is a key mediator, which connect between ROS and JNK in genipin-induced cell death signaling.	ros	113-116	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	42-64
17707342-2	2007	This continuing work aimed to define that mixed lineage kinase 3 (MLK3) is a key mediator, which connect between ROS and JNK in genipin-induced cell death signaling.	ros	113-116	mitogen-activated protein kinase kinase kinase 11	Homo sapiens	66-70
17458902-0	2007	IGF-I plus E2 induces proliferation via activation of ROS-dependent ERKs and JNKs in human breast carcinoma cells.	ros	54-57	cystatin 12, pseudogene	Homo sapiens	11-13
17458902-9	2007	These results indicate that IGF-I interacts with E2 to promote the proliferation of breast carcinoma cells via ROS-dependent MAPK activation and c-Jun protein expression.	ros	111-114	cystatin 12, pseudogene	Homo sapiens	49-51
17846503-6	2007	It also caused a loss of mitochondrial membrane potential that induced release of cytochrome c and apoptosis inducing factor (AIF) into the cytoplasm, enhancing ROS generation and subsequently resulting in apoptosis.	ros	161-164	apoptosis inducing factor mitochondria associated 1	Homo sapiens	126-129
17562703-7	2007	Furthermore, transfection of HPAECs with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated ROS production and the hyperoxia-induced translocation of p47(phox) to the cell periphery.	ros	150-153	cortactin	Homo sapiens	41-50
17562703-7	2007	Furthermore, transfection of HPAECs with cortactin small interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated ROS production and the hyperoxia-induced translocation of p47(phox) to the cell periphery.	ros	150-153	cortactin	Homo sapiens	90-99
17562703-9	2007	In addition, the hyperoxia-induced generation of ROS was significantly lower in ECs expressing a tyrosine-deficient mutant of cortactin than in vector control or wild-type cells.	ros	49-52	cortactin	Homo sapiens	126-135
17562703-10	2007	These data demonstrate a novel function for cortactin and actin in hyperoxia-induced activation of NADPH oxidase and ROS generation in human lung endothelial cells.	ros	117-120	cortactin	Homo sapiens	44-53
18371339-5	2007	Foxo3a(-/-) HSCs also showed increased phosphorylation of p38MAPK, an elevation of ROS, defective maintenance of quiescence, and heightened sensitivity to cell-cycle-specific myelotoxic injury.	ros	83-86	forkhead box O3	Mus musculus	0-6
17318368-7	2007	Furthermore, the antioxidant NAC prevented ROS generation and apoptosis by ajoene plus t10,c12CLA.	ros	43-46	NLR family, pyrin domain containing 1A	Mus musculus	29-32
17267144-5	2007	The earliest significant increase in ROS at 18 h, followed by mitochondrial membrane depolarization, caspase-3 activation and GSH depletion at 24h in spleen and later at 48 h in thymus, strongly implicate the possible involvement of ROS.	ros	233-236	caspase 3	Mus musculus	101-110
16987501-0	2006	Involvement of nitric oxide synthase and ROS-mediated activation of L-type voltage-gated Ca2+ channels in NMDA-induced DPYSL3 degradation.	ros	41-44	dihydropyrimidinase like 3	Homo sapiens	119-125
16987501-3	2006	Our preliminary results had shown that antioxidants significantly reduced NMDA-induced DPYSL3 degradation, indicating involvement of ROS in calpain activation.	ros	133-136	dihydropyrimidinase like 3	Homo sapiens	87-93
16987501-7	2006	The NMDA- and oxidative stress (ROS)-induced DPYSL3 truncation was totally dependent on extracellular [Ca(2+)](i).	ros	32-35	dihydropyrimidinase like 3	Homo sapiens	45-51
16762411-8	2006	These results suggest that in M07e cells calmodulin and CAMKII are involved in GLUT1 stimulation by cytokines and ROS.	ros	114-117	solute carrier family 2 member 1	Homo sapiens	79-84
16904205-3	2006	Moreover, ERK1/2 induction is dependent on ROS production as demonstrated by a complete removal of PDTC-mediated ERK1/2 phosphorylation by NAC.	ros	43-46	X-linked Kx blood group	Homo sapiens	139-142
16780805-7	2006	Cadmium (25 microM) induced apoptosis earliest at 6 h. Alterations in ROS and GSH preceded mitochondrial membrane depolarization and caspase-3 activation followed by apoptosis.	ros	70-73	caspase 3	Mus musculus	133-142
16885344-0	2006	ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice.	ros	0-3	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	39-74
16885344-6	2006	We show that this FIG-ROS-mediated tumor formation in vivo parallels the activation of the tyrosine phosphatase SH2 domain-containing phosphatase-2 (SHP-2) and a phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling axis in tumors and tumor-derived cell lines.	ros	22-25	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	112-147
16885344-6	2006	We show that this FIG-ROS-mediated tumor formation in vivo parallels the activation of the tyrosine phosphatase SH2 domain-containing phosphatase-2 (SHP-2) and a phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin signaling axis in tumors and tumor-derived cell lines.	ros	22-25	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	149-154
16944596-9	2006	Another was that PNS caused an increase in the production of ROS in hippocampal CA3 region and ROS caused an increase in the phosphorylation of HVA Ca2+ channel of offspring hippocampal CA3 neurons.	ros	61-64	carbonic anhydrase 3	Rattus norvegicus	80-83
16944596-9	2006	Another was that PNS caused an increase in the production of ROS in hippocampal CA3 region and ROS caused an increase in the phosphorylation of HVA Ca2+ channel of offspring hippocampal CA3 neurons.	ros	61-64	carbonic anhydrase 3	Rattus norvegicus	186-189
16944596-9	2006	Another was that PNS caused an increase in the production of ROS in hippocampal CA3 region and ROS caused an increase in the phosphorylation of HVA Ca2+ channel of offspring hippocampal CA3 neurons.	ros	95-98	carbonic anhydrase 3	Rattus norvegicus	186-189
16564497-7	2006	Thus, ROS production by flavoproteins is crucial for hypoxic upregulation of adrenomedullin mRNA in murine HL-1 cardiomyocytes.	ros	6-9	adrenomedullin	Mus musculus	77-91
16328008-8	2006	These data clearly indicate that increased cell proliferation was associated with the induction of cyclin D1 expression which was regulated by ERK in 4-HNE-treated young SMCs for 36 h. In contrast, we found that the cytotoxicity of aged SMCs to 4-HNE was partly related to generation of ROS and that pretreatment with N-acetyl-L-cysteine prevented 4-HNE-induced cell death in aged SMCs.	ros	287-290	cyclin D1	Mus musculus	99-108
16239241-4	2005	Inducing expression of A53T alpha-synuclein in differentiated PC12 cells decreased proteasome activity, increased the intracellular ROS level and caused up to approximately 40% cell death, which was accompanied by mitochondrial cytochrome C release and elevation of caspase-9 and -3 activities.	ros	132-135	synuclein alpha	Rattus norvegicus	28-43
16339585-2	2005	Because Rac1 is a component of the reactive oxidant species (ROS)-generating NADPH oxidase system, we investigated the role of this GTPase in ROS production in HCs.	ros	61-64	Rac family small GTPase 1	Homo sapiens	8-12
16339585-2	2005	Because Rac1 is a component of the reactive oxidant species (ROS)-generating NADPH oxidase system, we investigated the role of this GTPase in ROS production in HCs.	ros	142-145	Rac family small GTPase 1	Homo sapiens	8-12
16339585-7	2005	This allows the inactivation of SHP-1 by NOX5-generated ROS and contributes to the maintenance of the constitutive activation of HCs.	ros	56-59	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	32-37
15908180-2	2005	Using pancreatic beta-cell line MIN6N8 cells, co-treatment with TNF-alpha and IFN-gamma, but neither cytokine alone, synergistically induced apoptosis, correlated with the activation of the JNK/SAPK, which resulted in the production of reactive oxidative species (ROS) and loss of mitochondrial transmembrane potential (delta psi m).	ros	264-267	mitogen-activated protein kinase 8	Mus musculus	190-198
16184402-4	2005	We previously reported that ET-1 induces ROS generation via the ET(A) receptor and ROS modulates c-fos gene expression.	ros	83-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	97-102
15866424-9	2005	The ratio of PPARgamma to RXRalpha was predictive of how cells responded to co-treatment of Ros and 9-cis-retinoic acid, an RXRalpha agonist, in two out of three cell lines tested.	ros	92-95	retinoid X receptor alpha	Homo sapiens	26-34
15866424-9	2005	The ratio of PPARgamma to RXRalpha was predictive of how cells responded to co-treatment of Ros and 9-cis-retinoic acid, an RXRalpha agonist, in two out of three cell lines tested.	ros	92-95	retinoid X receptor alpha	Homo sapiens	124-132
16036323-6	2005	The constriction during reperfusion after 45 min of ischemia is supposedly caused by the inhibition of Akt-mediated eNOS-Ser1177 phosphorylation, which was suppressed by a PKC inhibitor chelerythrine, or ROS scavengers N-2-mercaptopropionyl glycine (MPG) and 4,5-Dihydroxy-1, 3-benzenedisulfonic acid disodium salt (Tiron).	ros	204-207	nitric oxide synthase 3	Rattus norvegicus	116-120
15659536-6	2005	The hypertensive effect of sEH inhibition is likely a result of an increase in epoxyeicosatrienoic acid (EET)-mediated generation of ROS.	ros	133-136	epoxide hydrolase 2	Rattus norvegicus	27-30
15743195-1	2005	In an effort to gain further insight into the conformational and topographical requirements for recognition by the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1, we synthesized a series of linear and cyclic peptides derived from the sequence surrounding phosphotyrosine 2267 in the receptor tyrosine kinase Ros (EGLNpYMVL).	ros	321-324	protein tyrosine phosphatase non-receptor type 6	Homo sapiens	169-174
15390122-8	2004	Ganglioside-induced ROS generation was blocked by PKC inhibitors.	ros	20-23	protein kinase C, alpha	Rattus norvegicus	50-53
14654169-3	2003	With the increasing concentration of antioxidants, such H2O2-induced cytotoxicity was significantly prevented and the corresponding intracellular and extracellular ROS levels decreased concurrently by pre-treatment with Asc2P6P and Asc.	ros	164-167	PYD and CARD domain containing	Rattus norvegicus	220-223
12745066-0	2003	Tyrosinase protects human melanocytes from ROS-generating compounds.	ros	43-46	tyrosinase	Homo sapiens	0-10
12745066-7	2003	Taken together these data suggest that tyrosinase represents an outstanding protective mechanism against ROS-generating compounds, once primary detoxifying mechanisms are impaired or not available.	ros	105-108	tyrosinase	Homo sapiens	39-49
12753864-9	2003	PTHrP maximally induced ICER mRNA at 2-4 h, which then returned to baseline by 10 h. Finally, PTH, FSK, and PTHrP induced ICER in cultured mouse calvariae and osteoblastic ROS 17/2.8, UMR-106, and Pyla cells.	ros	172-175	cAMP responsive element modulator	Mus musculus	122-126
12151057-10	2002	In contrast, pretreatment with millimolar dose of ASC or NAC maintained an elevated mitogenicity in response to insulin irrespective of the ROS/RNS donor type used.	ros	140-143	X-linked Kx blood group	Homo sapiens	57-60
11884618-6	2002	Whereas most of RACK1 resides in the cytoskeletal compartment of the cytoplasm, transformation of fibroblasts and epithelial cells by v-Src, oncogenic IR or oncogenic IGF-IR, but not by Ros or Ras, resulted in a significantly increased association of RACK1 with the membrane.	ros	186-189	receptor for activated C kinase 1	Homo sapiens	16-21
11401538-5	2001	Finally, a subset of agents that upregulated the expression of the reporter gene from the cloned promoter were also shown to increase the expression of the endogenous BMP-7 in G401 and ROS cell lines in vitro.	ros	185-188	bone morphogenetic protein 7	Homo sapiens	167-172
11145578-5	2001	PTHR were up-regulated by T(3) pretreatment (10(-)(10)-10(-)(6) M) in ROS 17/2.8 cells in a dose-dependent manner.	ros	70-73	parathyroid hormone 1 receptor	Rattus norvegicus	0-4
11145578-7	2001	Pretreatment with PTH (10(-)(10)-10(-)(6) M) or PTHrP (10(-)(9) M) for 3-4 days resulted in a dose-dependent up-regulation of TR in ROS 17/2.8 cells.	ros	132-135	parathyroid hormone-like hormone	Rattus norvegicus	48-53
11127200-8	2000	Using a natural dominant negative for AP-1 transcriptional activity in ROS 17/2.8 cells, we then showed that AP-1 transcription factors mediated TGF-beta1- and BMP-2-regulated expression of the (alpha1) collagen I gene as well as TGF-beta1-regulated expression of the parathyroid hormone (PTH)/PTH-related peptide (PTHrP) receptor.	ros	71-74	parathyroid hormone-like hormone	Rattus norvegicus	315-320
11116210-2	2000	ROS 17/2.8 cells, a rat osteoblast-like osteosarcoma cell line, express the PTH/PTHrP receptor and provide a good model for examining the transcriptional regulation of its gene.	ros	0-3	parathyroid hormone-like hormone	Rattus norvegicus	80-85
10976999-11	2000	Biological activity of the recovered hOP-1 was confirmed in vitro by showing induction of alkaline phosphatase activity in rat osteosarcoma cells (ROS) and in vivo by de novo endochondral bone formation in the subcutaneous space of the rat.	ros	147-150	bone morphogenetic protein 7	Homo sapiens	37-42
10962570-9	2000	However, the VP16 - p53 fusion failed to trigger caspases and subsequent induction of the ROS producing gene pig3 paralleled by complete loss of apoptotic activity.	ros	90-93	tumor protein p53 inducible protein 3	Homo sapiens	109-113
10967546-1	2000	Collagenase-3 expression in osteoblastic (UMR 106-01, ROS 17/2.8) and non-osteoblastic cell lines (BC1, NIH3T3) was examined.	ros	54-57	matrix metallopeptidase 13	Rattus norvegicus	0-13
10967546-5	2000	While c-fos was induced in UMR cells, both c-fos and jun B were induced in ROS cells.	ros	75-78	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	43-48
10967546-6	2000	Since Jun B is inhibitory of Fos and Jun in the regulation of the rat collagenase-3 gene in UMR cells, it is likely that high levels of Jun B prevent PTH stimulation of collagenase-3 in ROS cells.	ros	186-189	matrix metallopeptidase 13	Rattus norvegicus	169-182
10855687-5	2000	Using antisense-transfected ROS cells, PTH/PTHrP receptor mRNA expression and 125I-[Tyr36] PTHrP (1-36) binding were downregulated by treatment for 24 h with exogenous PTHrP (1-36), forskolin, or dibutyryl cAMP.	ros	28-31	parathyroid hormone-like hormone	Rattus norvegicus	43-48
10855687-5	2000	Using antisense-transfected ROS cells, PTH/PTHrP receptor mRNA expression and 125I-[Tyr36] PTHrP (1-36) binding were downregulated by treatment for 24 h with exogenous PTHrP (1-36), forskolin, or dibutyryl cAMP.	ros	28-31	parathyroid hormone-like hormone	Rattus norvegicus	91-96
10855687-5	2000	Using antisense-transfected ROS cells, PTH/PTHrP receptor mRNA expression and 125I-[Tyr36] PTHrP (1-36) binding were downregulated by treatment for 24 h with exogenous PTHrP (1-36), forskolin, or dibutyryl cAMP.	ros	28-31	parathyroid hormone-like hormone	Rattus norvegicus	91-96
10321921-5	1999	Further studies have shown that IL-6, c-fos, and Bcl-2 are all elevated in Paget"s disease--all of these factors can be activated by virally induced ROS.	ros	149-152	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
9572838-1	1998	Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated after PTH treatment.	ros	30-33	parathyroid hormone-like hormone	Rattus norvegicus	11-16
9550631-0	1998	Regulation of the transcription of parathyroid-hormone/parathyroid-hormone-related peptide receptor mRNA by dexamethasone in ROS 17/2.8 osteosarcoma cells.	ros	125-128	parathyroid hormone 1 receptor	Rattus norvegicus	35-99
9550631-1	1998	Previous studies have shown that dexamethasone enhanced the expression of parathyroid-hormone/parathyroid-hormone-related peptide (PTH/ PTHrP) receptor mRNA in ROS 17/2.8 osteosarcoma cells.	ros	160-163	parathyroid hormone-like hormone	Rattus norvegicus	136-141
9182583-9	1997	TIMP-4 and TIMP-2 but not TIMP-1 bound specifically to purified TIMP-2-free human recombinant full-length progelatinase A and to full-length rat proenzyme from the conditioned culture medium of ROS 17/2.8 cells.	ros	194-197	TIMP metallopeptidase inhibitor 2	Homo sapiens	11-17
9043648-1	1997	An attempt was made to reveal the mode of action of protons and salts on the recently discovered GTP gamma S-dependent interaction of bovine retinal rod outer segments (ROS)1 nucleoside diphosphate kinase (NDP kinase) with the complex between bleached visual receptor rhodopsin and retinal G-protein transducin in bovine ROS membranes.	ros	169-172	cytidine/uridine monophosphate kinase 1	Bos taurus	175-204
9043648-1	1997	An attempt was made to reveal the mode of action of protons and salts on the recently discovered GTP gamma S-dependent interaction of bovine retinal rod outer segments (ROS)1 nucleoside diphosphate kinase (NDP kinase) with the complex between bleached visual receptor rhodopsin and retinal G-protein transducin in bovine ROS membranes.	ros	169-172	cytidine/uridine monophosphate kinase 1	Bos taurus	206-216
9043648-2	1997	The properties of recombinant rat NDP kinase alpha, that is immunologically similar to the soluble NDP kinase from bovine ROS preparation, have been studied in solution by means of protein fluorescence at different pH and salt concentrations and results were compared with pH and salt effects on the binding of NDP kinase alpha to bleached bovine ROS membranes.	ros	122-125	cytidine/uridine monophosphate kinase 1	Rattus norvegicus	34-44
8760037-6	1996	Upregulation of HSP70 transcription via endogenous PTH receptors also was observed in the osteoblastic cell lines SaOS-2 and ROS 17/2.8.	ros	125-128	heat shock protein family A (Hsp70) member 4	Homo sapiens	16-21
8856978-5	1996	While the protective antioxidant responses induced by ROS in prokaryotes and eukaryotes are rather conserved (for example, SOD, HSP...), the regulators for these genes do not appear to be conserved.	ros	54-57	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	128-131
8856986-3	1996	We propose that mitochondria are a key organelle in determining the outcome of inflammation, because they are both the cellular "switchboard" for apoptosis and a selective target for the protective effects of HSP against the cytotoxic effects of TNF alpha and ROS.	ros	260-263	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	209-212
7649079-0	1995	Structure-function relationship of human parathyroid hormone in the regulation of vitamin D receptor expression in osteoblast-like cells (ROS 17/2.8).	ros	138-141	vitamin D receptor	Homo sapiens	82-100
7565445-4	1995	The functional significance of the cAMP effect is unknown, but preliminary findings indicated that PTHrP(107-139) also inhibited osteopontin mRNA levels in ROS 17/2.8 cells treated with peptide for 48 h. The results suggest that the carboxy-terminal region of PTHrP may play a role in bone metabolism by influencing osteoblast activity.	ros	156-159	parathyroid hormone-like hormone	Rattus norvegicus	99-104
9397968-0	1994	Transforming growth factor-beta1 regulates steady-state PTH/PTHrP receptor mRNA levels and PTHrP binding in ROS 17/2.8 osteosarcoma cells.	ros	108-111	parathyroid hormone-like hormone	Rattus norvegicus	91-96
8275958-6	1994	As previously reported, daily NlePTH treatment of ROS 17/2.8 cells reduced PTH/PTHrP receptor availability and PTH-stimulated cAMP accumulation markedly within 2 days, which remained at these low levels during continued PTH treatment.	ros	50-53	parathyroid hormone-like hormone	Rattus norvegicus	79-84
8275958-7	1994	In contrast, the identical treatment reduced steady state levels of PTH/PTHrP receptor mRNA in ROS 17/2.8 transiently and to only a slight extent, which then returned to pretreatment levels.	ros	95-98	parathyroid hormone-like hormone	Rattus norvegicus	72-77
8274878-0	1993	Modulation of parathyroid hormone-sensitive adenylate cyclase in ROS 17/2.8 cells by dexamethasone 1,25-dihydroxyvitamin D3 and protein kinase C.	ros	65-68	protein kinase C, gamma	Rattus norvegicus	128-144
8274878-1	1993	We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	ros	94-97	protein kinase C, gamma	Rattus norvegicus	22-38
8274878-1	1993	We tested whether the protein kinase C (PKC) modulation of PTH-sensitive adenylate cyclase in ROS 17/2.8 cells is affected by the glucocorticoid dexamethasone and the vitamin D hormone 1,25-dihydroxyvitamin D3 [1,25(OH)2D3].	ros	94-97	protein kinase C, gamma	Rattus norvegicus	40-43
8475799-1	1993	N-terminal fragments of PTH-related protein (PTHrP), PTHrP-(1-34), and PTHrP-(1-40) stimulated both adenylyl cyclase and a mechanism that increases membrane-associated protein kinase C (PKC) activity in ROS 17/2 rat osteosarcoma cells.	ros	203-206	parathyroid hormone-like hormone	Rattus norvegicus	24-43
8475799-1	1993	N-terminal fragments of PTH-related protein (PTHrP), PTHrP-(1-34), and PTHrP-(1-40) stimulated both adenylyl cyclase and a mechanism that increases membrane-associated protein kinase C (PKC) activity in ROS 17/2 rat osteosarcoma cells.	ros	203-206	parathyroid hormone-like hormone	Rattus norvegicus	45-50
8475799-1	1993	N-terminal fragments of PTH-related protein (PTHrP), PTHrP-(1-34), and PTHrP-(1-40) stimulated both adenylyl cyclase and a mechanism that increases membrane-associated protein kinase C (PKC) activity in ROS 17/2 rat osteosarcoma cells.	ros	203-206	parathyroid hormone-like hormone	Rattus norvegicus	53-58
8475799-1	1993	N-terminal fragments of PTH-related protein (PTHrP), PTHrP-(1-34), and PTHrP-(1-40) stimulated both adenylyl cyclase and a mechanism that increases membrane-associated protein kinase C (PKC) activity in ROS 17/2 rat osteosarcoma cells.	ros	203-206	parathyroid hormone-like hormone	Rattus norvegicus	53-58
8464915-6	1993	Deletion analysis of the mouse calbindin-D28k promoter as well as studies with a heterologous TK promoter resulted in identification of a butyrate-responsive element between -180 and -150 that was found to bind specifically to nuclear factors from butyrate-treated Ros 17/2.8 cells.	ros	265-268	calbindin 1	Mus musculus	31-45
1321277-2	1992	A recombinant with a 5" end from src and a 3" end from ros, called SRC x ROS, transformed chicken embryo fibroblasts (CEF) to a spindle shape morphology, mimicking that of UR2.	ros	55-58	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
1321277-2	1992	A recombinant with a 5" end from src and a 3" end from ros, called SRC x ROS, transformed chicken embryo fibroblasts (CEF) to a spindle shape morphology, mimicking that of UR2.	ros	73-76	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	67-70
1321277-4	1992	However, a transforming variant of ROS x SRC II appeared during passages of the transfected cells and was called ROS x SRC (R).	ros	35-38	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	41-44
1321277-4	1992	However, a transforming variant of ROS x SRC II appeared during passages of the transfected cells and was called ROS x SRC (R).	ros	113-116	SRC proto-oncogene, non-receptor tyrosine kinase	Gallus gallus	41-44
1321277-6	1992	Unlike RSV, ROS x SRC (R) also transformed CEF to an elongated shape similar to that of UR2.	ros	12-15	p60 src	Rous sarcoma virus	18-21
1324785-5	1992	Over-expression of PDGF-B in 4/7 glioblastoma cell lines, EGFR in 1/7, neu in 1/7 IGF-2 in 1/7 and ros in 2/7 was observed.	ros	99-102	platelet derived growth factor subunit B	Homo sapiens	19-25
1320001-6	1992	Activation of PKC with phorbol 12-myristate 13-acetate (PMA) did not cause an increase in osteocalcin secretion, while only a small increase in cellular content of osteocalcin in ROS 17/2.8 cells was observed.	ros	179-182	protein kinase C, gamma	Rattus norvegicus	14-17
1659514-11	1991	The biological activity of the PTH-rP in milk and plasma was assessed by its ability to stimulate cAMP accumulation in ROS 17/2.8 cells.	ros	119-122	parathyroid hormone-like hormone	Rattus norvegicus	31-37
1658637-3	1991	We report here that the hVDR is also phosphorylated in vivo after transfection into ROS 17/2.8 cells.	ros	84-87	vitamin D receptor	Homo sapiens	24-28
2103573-3	1990	Bioactive (BIO) PTHrP concentrations determined by cyclic AMP production by ROS 17/2.8 cells correlated significantly (P less than 0.001) with those obtained by RIA (BIO = 1.04RIA--3.4, r = 0.939).	ros	76-79	parathyroid hormone-like hormone	Rattus norvegicus	16-21
33819194-8	2021	In addition, PRDX2 knockdown led to increased ROS production in CD133+CD44+ CCSCs, sensitizing CCSCs to oxidative stress and chemotherapy.	ros	46-49	CD44 molecule (Indian blood group)	Homo sapiens	70-74
33232689-0	2021	Indoxyl sulfate induces ROS production via the aryl hydrocarbon receptor-NADPH oxidase pathway and inactivates NO in vascular tissues.	ros	24-27	aryl hydrocarbon receptor	Rattus norvegicus	47-72
34822966-7	2022	The Cat/Re@PLGA@UCM NPs also exhibited outstanding ROS scavenging properties, downregulating ICAM-1, TNF-alpha and IL-1beta, while preventing angiogenesis to attenuate the progression of AS.	ros	51-54	intercellular adhesion molecule 1	Homo sapiens	93-99
34847624-9	2022	The study provides evidence that alnustone is effective against HCC via ROS-mediated PI3K/Akt/mTOR/p70S6K pathway and the compound has the potential to be developed as a novel anticancer agent for the treatment of HCC clinically.	ros	72-75	ribosomal protein S6 kinase, polypeptide 1	Mus musculus	99-105
34973363-5	2022	The inhibitory effects and the redox cycling of shikonin towards TrxR1 caused cancer cell ROS-dependent necroptosis.	ros	90-93	thioredoxin reductase 1	Homo sapiens	65-70
34965422-3	2021	USP19 antagonizes RNF1-mediated ME1 degradation by deubiquitination, which in turn promotes lipid metabolism and NADPH production and suppresses ROS.	ros	145-148	ubiquitin specific peptidase 19	Homo sapiens	0-5
34965422-3	2021	USP19 antagonizes RNF1-mediated ME1 degradation by deubiquitination, which in turn promotes lipid metabolism and NADPH production and suppresses ROS.	ros	145-148	malic enzyme 1	Homo sapiens	32-35
34903714-7	2021	Downregulation of lncTRPM2-AS significantly decreased intracellular calcium levels by restraining TRPM2 protein expression, which in turn decreased ROS levels and increased autophagy to promote macrophage apoptosis and reduce cytokine production, together inhibiting macrophage inflammation.	ros	148-151	transient receptor potential cation channel subfamily M member 2	Homo sapiens	98-103
34715039-5	2021	Instead, by combining conditional disruption of the electron transport chain with deletion of tgcqmitochondrial aspartyl-tRNA synthetase, followed by single-cell sequencing analysis, we found that a subpopulation of early-stage wound macrophages are marked by mitochondrial ROS (mtROS) production and HIF1alpha stabilization, which ultimately drives a pro-angiogenic program essential for timely healing.	ros	274-277	aspartyl-tRNA synthetase	Mus musculus	112-136
34728372-7	2021	Additionally, the decreased long-chain acylcarnitine synthesis rate in TMLHE KO mice prevented ischaemia-reperfusion-induced ROS production in cardiac mitochondria.	ros	125-128	trimethyllysine hydroxylase, epsilon	Mus musculus	71-76
34597609-12	2021	IFN significantly prevents the neuroinflammation by decreasing the generation of ROS that reduces the activation of NLRP3/ASC/IL-1 axis thereby exerting neuroprotection as evidenced in rat model of STZ induced neuroninflammation.	ros	81-84	PYD and CARD domain containing	Rattus norvegicus	122-125
34592471-4	2021	The present study explores the effect of endocan on eNOS-iNOS-NO and ROS production in cultured endothelial cells.	ros	69-72	endothelial cell specific molecule 1	Homo sapiens	41-48
34592471-8	2021	The production of superoxide, hydrogen peroxide, peroxynitrite and total ROS were also significantly increased with endocan treatment supported by decreased activity of superoxide dismutase and catalase.	ros	73-76	endothelial cell specific molecule 1	Homo sapiens	116-123
34815381-8	2021	Finally, we demonstrated that HACE1 dramatically reduced cellular ROS levels by activating NRF2, thereby decreasing the response of glioma cells to radiation.	ros	66-69	HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1	Homo sapiens	30-35
34550632-4	2021	Finally, we demonstrate that depletion of CRIP2-as well as copper-induced CRIP2 degradation-elevates ROS levels and activates autophagy in H1299 cells.	ros	101-104	cysteine rich protein 2	Homo sapiens	42-47
34550632-4	2021	Finally, we demonstrate that depletion of CRIP2-as well as copper-induced CRIP2 degradation-elevates ROS levels and activates autophagy in H1299 cells.	ros	101-104	cysteine rich protein 2	Homo sapiens	74-79
34644617-10	2021	Altogether, deficiency of PDE4B inhibit the inflammasome activation and pyroptosis in LPS stimulated lung injury model and macrophages by regulating ROS/Nrf2/NLRP3 activation.	ros	149-152	phosphodiesterase 4B, cAMP specific	Mus musculus	26-31
34791251-7	2022	Notably, rGDF11 markedly promoted the activities of antioxidant enzymes in the ovary and testis, and remarkably reduced the levels of lipid peroxidation, protein oxidation and ROS in the ovary and testis.	ros	176-179	growth differentiation factor 11	Rattus norvegicus	9-15
34153908-8	2021	ROS including  OH,  O2- and 1O2 play critical role for SMX degradation.	ros	0-3	immunoglobulin kappa variable 1D-39	Homo sapiens	20-31
34600336-5	2021	Increased iron accumulation following HDAC inhibitor mediated EMT is associated with decreased expression of the iron export protein ferroportin, enhanced ROS production, and reduced expression of antioxidant response genes.	ros	155-158	histone deacetylase 9	Homo sapiens	38-42
34652584-5	2022	Then the elevated level of ROS activated the inflammatory response mediated by NLRP3 inflammasome (NLRP3, ASC, caspase-1).	ros	27-30	PYD and CARD domain containing	Rattus norvegicus	106-109
34652584-5	2022	Then the elevated level of ROS activated the inflammatory response mediated by NLRP3 inflammasome (NLRP3, ASC, caspase-1).	ros	27-30	caspase 1	Rattus norvegicus	111-120
34148735-7	2021	More interestingly, ROS scavenger (NAC) compensated the anti-proliferative and pro-apoptotic effects of Iberin on OC cells, suggesting the involvement of ROS in the regulation of Iberin on OC cell growth.	ros	20-23	X-linked Kx blood group	Homo sapiens	35-38
34148735-8	2021	Notably, Iberin induced down-regulation of glutathione peroxidase-1 (GPX1), and over-expression of GPX1 reversed Iberin-mediated alterations in the proliferation, apoptosis and ROS accumulation of OC cells.	ros	177-180	glutathione peroxidase 1	Homo sapiens	99-103
34347214-5	2021	AdoMet also increased ROS production and provoked protein and lipid oxidation.	ros	22-25	methionine adenosyltransferase 1A	Rattus norvegicus	0-6
34347214-7	2021	Free radical scavengers attenuated AdoMet effects on lipid peroxidation and GSH levels, supporting a role of ROS in these effects.	ros	109-112	methionine adenosyltransferase 1A	Rattus norvegicus	35-41
34568013-12	2021	Furthermore, we revealed that SLC25A21 suppressed BCa growth by inducing the efflux of mitochondrial alpha-KG to the cytosol, decreasing to against oxidative stress, and activating the ROS-mediated mitochondrion-dependent apoptosis pathway.	ros	185-188	solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21	Mus musculus	30-38
34287039-6	2021	Inhibition of PERK or ERO1alpha repressed ROS production in PCV2-infected cells and increased HMGB1 retention within nuclei.	ros	42-45	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	22-31
34287039-7	2021	These findings indicate that PCV2-induced activation of the PERK-ERO1alpha axis would lead to enhanced generation of ROS sufficient to decrease HMGB1 retention in the nuclei, thus derepressing viral DNA from HMGB1 sequestration.	ros	117-120	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	65-74
34287039-8	2021	The viral Rep and Cap proteins were able to induce PERK-ERO1alpha-mediated ROS accumulation.	ros	75-78	endoplasmic reticulum oxidoreductase 1 alpha	Homo sapiens	56-65
34503454-9	2021	Conversely, METTL14 silence decreased the levels of ROS, TNF-alpha and IL-6 and cell apoptosis.	ros	52-55	methyltransferase 14, N6-adenosine-methyltransferase subunit	Homo sapiens	12-19
34369082-4	2021	Our results show that GAPDH and DNM3OS were upregulated in HD PC12 cells, downregulation of which lead to inhibition of aggregate formation accompanied by a decreased apoptosis rate and increased relative ROS levels and cell viability.	ros	205-208	glyceraldehyde-3-phosphate dehydrogenase	Rattus norvegicus	22-27
34408077-0	2021	Treatment with ROS detoxifying gold quantum clusters alleviates the functional decline in a mouse model of Friedreich ataxia.	ros	15-18	frataxin	Mus musculus	107-124
34114917-8	2021	After transfection of miR-210 mimics, the attenuation of pyroptosis induced by paeoniflorin was suppressed, which was accompanied by an increase of ROS levels, as well as LDH release, indicating a critical role of miR-210 in pyroptosis in astrocytes.Conclusions: Our findings demonstrated that paeoniflorin improved hypoxia-induced pyroptosis in astrocytes via depressing hif1a/miR-210/caspase1/GSDMD signaling, providing robust evidence for the treatment of hypoxic injury and OSAHS.HighlightsHypoxia induces severe injury and inflammatory response in the rat brain;Hypoxia enhanced pyroptotic level and led to an activation of astrocytes.	ros	148-151	hypoxia inducible factor 1 subunit alpha	Rattus norvegicus	372-377
34458194-3	2021	Recent studies have shown that TGF-beta, through upregulation of pro-oxidant enzymes such as NOX2 and NOX4, promotes continuous ROS production and accumulation of fibrosis.	ros	128-131	transforming growth factor alpha	Rattus norvegicus	31-39
34458194-3	2021	Recent studies have shown that TGF-beta, through upregulation of pro-oxidant enzymes such as NOX2 and NOX4, promotes continuous ROS production and accumulation of fibrosis.	ros	128-131	cytochrome b-245 beta chain	Rattus norvegicus	93-97
34458194-3	2021	Recent studies have shown that TGF-beta, through upregulation of pro-oxidant enzymes such as NOX2 and NOX4, promotes continuous ROS production and accumulation of fibrosis.	ros	128-131	NADPH oxidase 4	Rattus norvegicus	102-106
34138758-5	2021	We demonstrate that STAT4 is required for multiple neutrophil functions including IL-12-induced ROS production, neutrophil chemotaxis, and production of neutrophil extracellular traps.	ros	96-99	signal transducer and activator of transcription 4	Mus musculus	20-25
34234193-10	2021	Our results suggest that metformin in cancer cells differentially regulates cellular ROS levels via AMPK-FOXO3a-MnSOD pathway and combination of metformin/apigenin exerts anticancer activity through DNA damage-induced apoptosis, autophagy and necroptosis by cancer cell-specific ROS amplification.	ros	85-88	forkhead box O3	Mus musculus	105-111
34169392-0	2021	ZEB1 directly inhibits GPX4 transcription contributing to ROS accumulation in breast cancer cells.	ros	58-61	zinc finger E-box binding homeobox 1	Homo sapiens	0-4
34169392-5	2021	RESULTS: We observed ZEB1 could inhibit GPX4 transcription by binding to the E-box motifs and promote breast cancer progression by accumulating intracellular ROS.	ros	158-161	zinc finger E-box binding homeobox 1	Homo sapiens	21-25
34127497-10	2021	SIGNIFICANCE: Loss of different succinate dehydrogenase subunits can lead to different cell and tumor phenotypes, linking stronger 2-OG-dependent dioxygenases inhibition, iron overload, and ROS accumulation following SDHB mutation.	ros	190-193	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	217-221
34206365-6	2021	The ALF-induced decrease of eNOS content and its uncoupling concurred with, and was likely causally related to, both increased brain content of reactive oxidative species (ROS) and decreased cerebral cortical blood flow (CBF) in the same model.	ros	172-175	nitric oxide synthase 3	Rattus norvegicus	28-32
34208019-8	2021	AOP1, the first technology linking a fine-tuning of cell ROS production with a quantitative signal, appears to be the most promising tool for the assessment of direct cellular ROS-scavenging effects at an industrial scale.	ros	57-60	peroxiredoxin 3	Homo sapiens	0-4
34208019-8	2021	AOP1, the first technology linking a fine-tuning of cell ROS production with a quantitative signal, appears to be the most promising tool for the assessment of direct cellular ROS-scavenging effects at an industrial scale.	ros	176-179	peroxiredoxin 3	Homo sapiens	0-4
34140895-1	2021	A previous study from our team found that hyperbaric oxygen (HBO) pretreatment attenuated decompression sickness (DCS) spinal cord injury by upregulating heat shock protein 32 (HSP32) via the ROS/p38 MAPK pathway.	ros	192-195	heme oxygenase 1	Rattus norvegicus	154-175
34140895-1	2021	A previous study from our team found that hyperbaric oxygen (HBO) pretreatment attenuated decompression sickness (DCS) spinal cord injury by upregulating heat shock protein 32 (HSP32) via the ROS/p38 MAPK pathway.	ros	192-195	heme oxygenase 1	Rattus norvegicus	177-182
34205973-0	2021	The AtCRK5 Protein Kinase Is Required to Maintain the ROS NO Balance Affecting the PIN2-Mediated Root Gravitropic Response in Arabidopsis.	ros	54-57	cysteine-rich RLK (RECEPTOR-like protein kinase) 5	Arabidopsis thaliana	4-10
34205973-10	2021	The potential involvement of AtCRK5 protein kinase in the control of auxin-ROS-NO-PIN2-auxin regulatory loop is discussed.	ros	75-78	cysteine-rich RLK (RECEPTOR-like protein kinase) 5	Arabidopsis thaliana	29-35
34067282-4	2021	AGE/RAGE signaling has been shown to alter protein expression and ROS production in cardiac fibroblasts, resulting in changes in cellular function, such as migration and contraction.	ros	66-69	renin binding protein	Mus musculus	0-3
35318880-0	2022	TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination.	ros	15-18	TNF receptor associated factor 3	Homo sapiens	0-5
35318880-12	2022	CONCLUSIONS: This study identified that TRAF3 promoted ROS-induced oxidative stress in model of cardiac infarction through the regulation of ULK1 ubiquitination, which could potentially give rise to a new strategy for the treatment of cardiac infarction.	ros	55-58	TNF receptor-associated factor 3	Mus musculus	40-45
35490584-7	2022	Notably, compound 7w, which had the highest activity and low cytotoxicity, was demonstrated to remarkably reduce intracellular ROS accumulation by activating the mRNA expression of Nrf2 and its downstream antioxidant gene HO-1, indicating a novel promising antioxidant and Nrf2 activator.	ros	127-130	heme oxygenase 1	Rattus norvegicus	222-226
35346830-9	2022	This study showed that miR-1656 could increase the release of ROS by targeting GPX4, activated the NLRP3 inflammasome, and release the inflammatory factors IL-1beta and IL-18 to trigger pyroptosis in the kidney tissue of Se-deficient broilers.	ros	62-65	interleukin 18	Homo sapiens	169-174
35513096-0	2022	N-acetylneuraminic acid and chondroitin sulfate modified nanomicelles with ROS-sensitive H2S donor via targeting E-selectin receptor and CD44 receptor for the efficient therapy of atherosclerosis.	ros	75-78	CD44 molecule (Indian blood group)	Homo sapiens	137-141
35413388-4	2022	Lentivirus-mediated shRNA targeting NOX4 inhibited oxidative stress by reducing ROS, 4-HNE and MDA levels, and increasing SOD and GPX activities in rat ovaries.	ros	80-83	NADPH oxidase 4	Rattus norvegicus	36-40
35616702-0	2022	Correction to: Matrix metalloproteinase-7 induces E-cadherin cleavage in acid-exposed primary human pharyngeal epithelial cells via the ROS/ERK/c-Jun pathway.	ros	136-139	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	144-149
35581617-9	2022	Besides, GLP-1 down-regulated the ROS that caused by AGEs and the mRNA and protein expression of Rage .	ros	34-37	glucagon	Rattus norvegicus	9-14
35581617-11	2022	The mechanism of these effects may be partly mediated by AGEs-RAGE-ROS pathway via the interaction with GLP-1 receptor.	ros	67-70	glucagon-like peptide 1 receptor	Rattus norvegicus	104-118
35521772-12	2022	Furthermore, oleic acid treatment induced ROS production and inflammasome activation, which is manifested by enhanced caspase-1 activity and mature IL-18 protein level.	ros	42-45	interleukin 18	Homo sapiens	148-153
35442666-6	2022	Downregulation of CASTOR1 inhibits heat-stress-induced apoptosis through a ROS-independent pathway.	ros	75-78	cytosolic arginine sensor for mTORC1 subunit 1	Homo sapiens	18-25
35384580-7	2022	The STZ-mediated stimulation of TRPM2 increased the cytosolic Ca2+, lipid peroxidation, mitROS, cytosolic ROS, apoptosis, caspase-3, caspase-8, and caspase-9 concentrations in the mice, although their concentrations were decreased in the optic nerve by the treatments of Se and RSV.	ros	106-109	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	32-37
35624746-2	2022	The inhibition of MAO-B affords higher dopamine bioavailability and stops ROS formation.	ros	74-77	monoamine oxidase B	Homo sapiens	18-23
35024788-5	2022	Our data first suggest that BER itself (25 nM) does not affect embryo quality or future developmental potency, moreover, it can effectively alleviate LPS-induced embryonic damage by mitigating apoptosis via ROS-/caspase-3-dependent pathways and by suppressing pro-inflammatory cytokines via inhibition of NF-kappaB signaling pathway during preimplantation embryo development.	ros	207-210	caspase 3	Mus musculus	212-221
35563730-8	2022	Moreover, TRPM2 knockout reduced the expression of ICAM-1, MCP-1, and TNFalpha and decreased the ROS level in the plaque region, suggesting a role of TRPM2 in enhancing monocyte adhesion and promoting vascular inflammation.	ros	97-100	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	150-155
35563730-9	2022	In bone-marrow-derived macrophages and primary cultured arterial endothelial cells, TRPM2 knockout reduced the production of inflammatory cytokines/factors and decreased ROS production.	ros	170-173	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	84-89
35563730-12	2022	Mechanistically, TRPM2 channels may provide an essential link that can connect ROS to Ca2+ and inflammation, consequently promoting atherosclerotic progression.	ros	79-82	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	17-22
35396977-6	2022	Our transcriptome data suggest that Cd triggers ROS production and photosynthesis decline associated with increased proteolysis through ubiquitin-proteasome system (UPS)- and chloroplast-proteases and in this way brings about re-mobilization of N and C stores into amino acids and sugars.	ros	48-51	ubiquitin	Raphanus sativus	136-145
35510387-10	2022	We further demonstrated that SDH inhibition dampened oxidative phosphorylation, reduced ferroptotic events, and restored ferroptotic cell death, characterized by eliminated mitochondrial ROS levels, decreased cellular ROS and diminished peroxide accumulation.	ros	187-190	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	29-32
35510387-10	2022	We further demonstrated that SDH inhibition dampened oxidative phosphorylation, reduced ferroptotic events, and restored ferroptotic cell death, characterized by eliminated mitochondrial ROS levels, decreased cellular ROS and diminished peroxide accumulation.	ros	218-221	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	29-32
35353897-16	2022	These findings reveal a novel HBx regulatory HMGA2/STC2 pathway in counteracting ROS-induced cell death.	ros	81-84	stanniocalcin 2	Homo sapiens	51-55
35387264-17	2022	Ageing increased the level of ROS and the expression of NOX4, oxidative CaMKII (ox-CaMKII), phosphorated CaMKII (p-CaMKII), and periostin.	ros	30-33	periostin	Rattus norvegicus	128-137
35538041-8	2022	Further experiments demonstrates that H19 regulates HEI-OC1 cell viability, ATP level, mitochondrial membrane potential, mitochondrial ROS generation, and cell apoptosis ratio via the miR-653-5p/SIRT1 axis.	ros	135-138	sirtuin 1	Homo sapiens	195-200
35044455-7	2022	Beside, knock-down of FBXO17 inhibited mitochondrial membrane potential, and increased ROS.	ros	87-90	F-box protein 17	Homo sapiens	22-28
35302183-10	2022	Overall, these results indicate that SIDT2 regulates the miR-25/NOX4/HuR axis and SIRT3 mRNA destabilization, leading to ROS-mediated TNF-alpha upregulation in HQ-treated U937 cells.	ros	121-124	SID1 transmembrane family member 2	Homo sapiens	37-42
35051861-14	2022	Furthermore, LV-Pparg overexpression PPARgamma attenuated NADPH oxidase activity, which was shown as the reduction of the NOX2 and p22phox expression by western blot analysis, decreased the MDA production and increased the SOD and GPx activities by ELISA, finally led to reduce AGEs-mediated ROS production.	ros	292-295	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	37-46
35051861-15	2022	Moreover, activating PPARgamma by LV-Pparg inhibited AGEs-induced phosphorylation of p38 MAPK, by which could reduce AGEs-mediated NOX2, p22phox expression and ROS production, while CSMCs treatment with SB203580 (10 mumol/L), a p38 MAPK inhibitor, attenuated these effects.	ros	160-163	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	21-30
35051861-15	2022	Moreover, activating PPARgamma by LV-Pparg inhibited AGEs-induced phosphorylation of p38 MAPK, by which could reduce AGEs-mediated NOX2, p22phox expression and ROS production, while CSMCs treatment with SB203580 (10 mumol/L), a p38 MAPK inhibitor, attenuated these effects.	ros	160-163	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	37-42
35051861-16	2022	Activating PPARgamma plays a protective role in AGEs-induced impairment of coronary artery vasodilation by inhibiting p38 phosphorylation to attenuate NOX2 and p22phox expression and further decrease oxidative stress induced by ROS overproduction.	ros	228-231	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	11-20
35088536-7	2022	These detrimental effects may be associated with regulating NOX/ROS/P38MARK pathway by MST1/2.	ros	64-67	macrophage stimulating 1 (hepatocyte growth factor-like)	Mus musculus	87-93
35196483-4	2022	The ROS-dependent TRAF6-mediated non-proteolytic, K48/63-linked ubiquitination of ATG9A enhances its association with Beclin 1 and the assembly of VPS34-UVRAG complex, thereby stimulating autophagy.	ros	4-7	beclin 1	Homo sapiens	118-126
35215001-5	2022	It was validated that perilipin-coated aLDs could be uptaken by cells, significantly reducing hydrogen peroxide-induced reactive oxidative species (ROS) and alleviating cellular lipotoxicity caused by excess fatty acid.	ros	148-151	perilipin 1	Homo sapiens	22-31
35216295-8	2022	In cultured cardiomyocytes, palmitate increased mitochondrial ROS production, depleted ATP production and promoted apoptosis, all of which were attenuated by ABAT over-expression.	ros	62-65	4-aminobutyrate aminotransferase	Mus musculus	158-162
35102232-5	2022	Several DEGs enriched in plant signal transduction pathways were highly expressed under salt stress, and these genes play an important role in signaling and scavenging of ROS in response to salt stress.	ros	171-174	delta 4-desaturase, sphingolipid 1	Homo sapiens	8-12
35204157-9	2022	The increase in IGFBP6 was able, in turn, to improve the mitochondrial fitness and redox state, as suggested by the reduced levels of mitochondrial ROS production after IGFBP6 treatment, presumably mediated by the increase in the ROS detoxifying genes HMOX1, GSTK1 and NQO1.	ros	148-151	insulin like growth factor binding protein 6	Homo sapiens	16-22
35204157-9	2022	The increase in IGFBP6 was able, in turn, to improve the mitochondrial fitness and redox state, as suggested by the reduced levels of mitochondrial ROS production after IGFBP6 treatment, presumably mediated by the increase in the ROS detoxifying genes HMOX1, GSTK1 and NQO1.	ros	148-151	insulin like growth factor binding protein 6	Homo sapiens	169-175
35204157-9	2022	The increase in IGFBP6 was able, in turn, to improve the mitochondrial fitness and redox state, as suggested by the reduced levels of mitochondrial ROS production after IGFBP6 treatment, presumably mediated by the increase in the ROS detoxifying genes HMOX1, GSTK1 and NQO1.	ros	230-233	insulin like growth factor binding protein 6	Homo sapiens	16-22
35204157-9	2022	The increase in IGFBP6 was able, in turn, to improve the mitochondrial fitness and redox state, as suggested by the reduced levels of mitochondrial ROS production after IGFBP6 treatment, presumably mediated by the increase in the ROS detoxifying genes HMOX1, GSTK1 and NQO1.	ros	230-233	insulin like growth factor binding protein 6	Homo sapiens	169-175
35043976-5	2022	Such improved immunotherapy response by MCT4 targeting was due to combined consequences, characterized by the alleviated acidification of tumor microenvironment (TME) and elevated the CXCL9/CXCL10 secretion induced by ROS/NF-kappaB signaling pathway.	ros	218-221	C-X-C motif chemokine ligand 10	Homo sapiens	190-196
35075949-0	2022	Uranium induces kidney cells pyroptosis in culture involved in ROS/NLRP3/Caspase-1 signaling.	ros	63-66	caspase 1	Rattus norvegicus	73-82
35075949-8	2022	Taken together, our results suggest that U-treatment can trigger NRK-52E cells pyroptosis which is involvement of ROS/NLRP3/Caspase-1 pathway.	ros	114-117	caspase 1	Rattus norvegicus	124-133
35075949-9	2022	Targeting ROS/NLRP3/Caspase-1-mediated pyroptosis may be a novel approach for attenuating U nephrotoxicity.	ros	10-13	caspase 1	Rattus norvegicus	20-29