PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31098741-14	2019	Bol08504 is homologous to CER1, which encodes fatty acid hydroxylase and plays an important role in wax synthesis in Arabidopsis.	Waxes	100-103	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	26-30
32803027-2	2020	One of the major concerns especially in waters like the South China Sea is the deposition of wax on the walls of the pipeline or wellbore, constricting and hindering the hydrocarbon flow.	Waxes	93-96	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	68-71
32085442-5	2020	In contrast, knockout of LACS2 in the lacs2-3 mutant resulted in hypersensitivity to submergence with reduced wax crystals and thinner cutin layer.	Waxes	110-113	long-chain acyl-CoA synthetase 2	Arabidopsis thaliana	25-30
32085442-5	2020	In contrast, knockout of LACS2 in the lacs2-3 mutant resulted in hypersensitivity to submergence with reduced wax crystals and thinner cutin layer.	Waxes	110-113	long-chain acyl-CoA synthetase 2	Arabidopsis thaliana	38-43
32719695-9	2020	Total wax loads increased by 1.5- to 3.3-fold in leaves of RAP2.4 OX plants relative to WT.	Waxes	6-9	related to AP2 4	Arabidopsis thaliana	59-65
32473079-5	2020	For wax-coated cotton dressings, several methods of loading of 2dDR were explored.	Waxes	4-7	Discoidin domain receptor	Drosophila melanogaster	64-67
32342434-8	2020	Overexpression of AtDBP1 showed increased cuticular conductance due to a decreased cuticle wax accumulation and cuticle membrane thickness.	Waxes	91-94	DNA-binding protein phosphatase 1	Arabidopsis thaliana	18-24
31484683-0	2019	Diurnal Regulation of Plant Epidermal Wax Synthesis through Antagonistic Roles of the Transcription Factors SPL9 and DEWAX.	Waxes	38-41	squamosa promoter binding protein-like 9	Arabidopsis thaliana	108-112
31484683-0	2019	Diurnal Regulation of Plant Epidermal Wax Synthesis through Antagonistic Roles of the Transcription Factors SPL9 and DEWAX.	Waxes	38-41	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	117-122
31484683-4	2019	In this paper, we report the regulation of cuticular wax production by the miR156-SPL9 (SQUAMOSA PROMOTER BINDING PROTEIN-LIKE 9) module in Arabidopsis (Arabidopsis thaliana).	Waxes	53-56	squamosa promoter binding protein-like 9	Arabidopsis thaliana	82-86
30824083-4	2019	The paper sample modified with a wax-treated (CR/CS/MMT/CS)2 multilayer gave a water contact angle of 151.4 .	Waxes	33-36	chorionic somatomammotropin hormone 2	Homo sapiens	46-60
31320482-3	2019	Here, we report that the Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis.	Waxes	286-289	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	165-176
31320482-3	2019	Here, we report that the Arabidopsis (Arabidopsis thaliana) Kelch repeat F-box protein SMALL AND GLOSSY LEAVES1 (SAGL1) mediates proteasome-dependent degradation of ECERIFERUM3 (CER3), a biosynthetic enzyme involved in the production of very long chain alkanes (the major components of wax), thereby negatively regulating cuticular wax biosynthesis.	Waxes	286-289	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	178-182
30460223-0	2018	A Simple SERS-Based Trace Sensing Platform Enabled by AuNPs-Analyte/AuNPs Double-Decker Structure on Wax-Coated Hydrophobic Surface.	Waxes	101-104	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	9-13
28838126-6	2017	Genetic analysis reveals that wax accumulation of the miel1 mutant is compromised by myb96 or myb30 mutation, but MYB96 is mainly epistatic to MIEL1, playing a predominant role in cuticular wax deposition.	Waxes	30-33	CHY-type/CTCHY-type/RING-type Zinc finger protein	Arabidopsis thaliana	54-59
30223774-4	2018	Four wax biosynthesis related genes, including two wax backbone genes ECERIFERUM 1 (CER1) and CER3, one regulatory gene CER7 and one transport gene CER5, were cloned and sequenced.	Waxes	5-8	cerberus 1, DAN family BMP antagonist	Homo sapiens	84-88
29506042-0	2018	GCN5 contributes to stem cuticular wax biosynthesis by histone acetylation of CER3 in Arabidopsis.	Waxes	35-38	general control non-repressible 5	Arabidopsis thaliana	0-4
29506042-0	2018	GCN5 contributes to stem cuticular wax biosynthesis by histone acetylation of CER3 in Arabidopsis.	Waxes	35-38	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	78-82
29506042-6	2018	Notably, overexpression of CER3 in the gcn5-2 mutant rescued the defect in stem cuticular wax biosynthesis.	Waxes	90-93	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	27-31
29506042-6	2018	Notably, overexpression of CER3 in the gcn5-2 mutant rescued the defect in stem cuticular wax biosynthesis.	Waxes	90-93	histone acetyltransferase of the GNAT family 1	Arabidopsis thaliana	39-43
28838126-6	2017	Genetic analysis reveals that wax accumulation of the miel1 mutant is compromised by myb96 or myb30 mutation, but MYB96 is mainly epistatic to MIEL1, playing a predominant role in cuticular wax deposition.	Waxes	30-33	myb domain protein 96	Arabidopsis thaliana	85-90
28838126-6	2017	Genetic analysis reveals that wax accumulation of the miel1 mutant is compromised by myb96 or myb30 mutation, but MYB96 is mainly epistatic to MIEL1, playing a predominant role in cuticular wax deposition.	Waxes	30-33	myb domain protein 30	Arabidopsis thaliana	94-99
28421085-0	2017	Expression of Arabidopsis SHN1 in Indian Mulberry (Morus indica L.) Increases Leaf Surface Wax Content and Reduces Post-harvest Water Loss.	Waxes	91-94	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	26-30
28407124-7	2017	The abundances of both branched wax constituents and accompanying unbranched compounds were reduced on the cer6, cer3 and cer1 mutants but not cer4, indicating that branched compounds are in part synthesized by the same machinery as unbranched compounds.	Waxes	32-35	3-ketoacyl-CoA synthase 6	Arabidopsis thaliana	107-111
28407124-7	2017	The abundances of both branched wax constituents and accompanying unbranched compounds were reduced on the cer6, cer3 and cer1 mutants but not cer4, indicating that branched compounds are in part synthesized by the same machinery as unbranched compounds.	Waxes	32-35	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	113-117
28407124-7	2017	The abundances of both branched wax constituents and accompanying unbranched compounds were reduced on the cer6, cer3 and cer1 mutants but not cer4, indicating that branched compounds are in part synthesized by the same machinery as unbranched compounds.	Waxes	32-35	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	122-126
28421085-7	2017	Mulberry transgenic plants expressing AtSHN1 displayed dark green shiny appearance with increased leaf surface wax content.	Waxes	111-114	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	38-44
27496682-4	2016	In the stem wax, compounds with aliphatic chains longer than 31 carbons (derived from C32 precursors) increased in relative abundance in cpc tcl1 etc1 etc3 over gl1.	Waxes	12-15	myb domain protein 0	Arabidopsis thaliana	161-164
28184233-8	2017	At5g02890 is localized to the endoplasmic reticulum (ER), which is consistent with its function in cuticular wax biosynthesis.	Waxes	109-112	HXXXD-type acyl-transferase family protein	Arabidopsis thaliana	0-9
27577115-4	2016	MYB94 complemented the wax-deficient phenotype of the myb96 loss-of-function mutant under both well-watered and drought stress conditions.	Waxes	23-26	myb domain protein 94	Arabidopsis thaliana	0-5
27577115-4	2016	MYB94 complemented the wax-deficient phenotype of the myb96 loss-of-function mutant under both well-watered and drought stress conditions.	Waxes	23-26	myb domain protein 96	Arabidopsis thaliana	54-59
27577115-5	2016	The magnitude of decrease in total wax load in the myb94 myb96 double mutant was almost equal to the sum of the reduced wax loads in the individual myb94 and myb96 mutants under both conditions.	Waxes	35-38	myb domain protein 94	Arabidopsis thaliana	51-56
27577115-5	2016	The magnitude of decrease in total wax load in the myb94 myb96 double mutant was almost equal to the sum of the reduced wax loads in the individual myb94 and myb96 mutants under both conditions.	Waxes	35-38	myb domain protein 96	Arabidopsis thaliana	57-62
27337244-0	2016	Cuticular wax biosynthesis is positively regulated by WRINKLED4, an AP2/ERF-type transcription factor, in Arabidopsis stems.	Waxes	10-13	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	54-63
27337244-0	2016	Cuticular wax biosynthesis is positively regulated by WRINKLED4, an AP2/ERF-type transcription factor, in Arabidopsis stems.	Waxes	10-13	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	68-71
27337244-3	2016	In this study, we found that WRINKLED4 (WRI4), encoding an AP2/ERF (ethylene-responsive factor) transcription factor (TF), is predominantly expressed in stem epidermis, is upregulated by salt stress, and is involved in activating cuticular wax biosynthesis in Arabidopsis stems.	Waxes	240-243	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	29-38
27337244-3	2016	In this study, we found that WRINKLED4 (WRI4), encoding an AP2/ERF (ethylene-responsive factor) transcription factor (TF), is predominantly expressed in stem epidermis, is upregulated by salt stress, and is involved in activating cuticular wax biosynthesis in Arabidopsis stems.	Waxes	240-243	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	40-44
27337244-3	2016	In this study, we found that WRINKLED4 (WRI4), encoding an AP2/ERF (ethylene-responsive factor) transcription factor (TF), is predominantly expressed in stem epidermis, is upregulated by salt stress, and is involved in activating cuticular wax biosynthesis in Arabidopsis stems.	Waxes	240-243	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	59-62
27354553-4	2016	CCR2 catalyzes the biosynthesis of carotenoids, whereas CER3 is involved in the biosynthesis of cuticular wax.	Waxes	106-109	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	56-60
24738593-6	2014	We also noticed a strong decrease in C20 1,2-alkane diols consistent with the decrease of wax diesters in the sebum of Cers4-/- mice.	Waxes	90-93	ceramide synthase 4	Mus musculus	119-124
26093144-7	2015	Interestingly several of the Arabidopsis MYB genes most closely related to ZmMYB94 are also involved in the activation of cuticular wax biosynthesis, suggesting deep conservation of regulatory processes related to cuticular wax deposition between monocots and dicots.	Waxes	132-135	Transcription factor MYB96	Zea mays	75-82
26093144-7	2015	Interestingly several of the Arabidopsis MYB genes most closely related to ZmMYB94 are also involved in the activation of cuticular wax biosynthesis, suggesting deep conservation of regulatory processes related to cuticular wax deposition between monocots and dicots.	Waxes	224-227	Transcription factor MYB96	Zea mays	75-82
26019301-3	2015	It is shown here that silencing of the TAGL1 gene (RNA interference lines) promotes significant changes affecting cuticle development, mainly a reduction of thickness and stiffness, as well as a significant decrease in the content of cuticle components (cutin, waxes, polysaccharides, and phenolic compounds).	Waxes	261-266	TAGL1 transcription factor	Solanum lycopersicum	39-44
25468933-6	2015	Evidence is presented for a new function for TaFAR5 in the biosynthesis of primary alcohols of leaf blade cuticular wax in wheat.	Waxes	116-119	alcohol-forming fatty acyl-CoA reductase	Triticum aestivum	45-51
25256798-3	2015	As a scouring agent for cotton fabrics, the lipase from B. sonorensis was capable of removing substantial amount of wax from the cotton surface and hydrolyzing it into fatty acids.	Waxes	116-119	GDSL esterase/lipase At5g18430-like	Gossypium hirsutum	44-50
25305760-7	2015	An increase in the accumulation of cuticular wax was observed to reduce the rate of cuticular transpiration in the leaves of MYB94 OX lines, under drought stress conditions.	Waxes	45-48	myb domain protein 94	Arabidopsis thaliana	125-130
25305760-8	2015	Taken together, a R2R3-type MYB94 transcription factor activates Arabidopsis cuticular wax biosynthesis and might be important in plant response to environmental stress, including drought.	Waxes	87-90	myb domain protein 94	Arabidopsis thaliana	28-33
25053648-7	2014	Consequently, the acbp1 mutant showed fewer wax crystals on the stem surface in scanning electron microscopy and an irregular stem cuticle layer in transmission electron microscopy in comparison with the wild type.	Waxes	44-47	acyl-CoA binding protein 1	Arabidopsis thaliana	18-23
25305760-0	2015	Cuticular wax biosynthesis is up-regulated by the MYB94 transcription factor in Arabidopsis.	Waxes	10-13	myb domain protein 94	Arabidopsis thaliana	50-55
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Waxes	87-92	acetone-cyanohydrin lyase	Arabidopsis thaliana	138-155
24844815-1	2014	Cytosolic acetyl-CoA is involved in the synthesis of a variety of compounds, including waxes, sterols and rubber, and is generated by the ATP citrate lyase (ACL).	Waxes	87-92	acetone-cyanohydrin lyase	Arabidopsis thaliana	157-160
25763625-6	2014	Cuticular wax biosynthesis is negatively regulated twice a day by the expression of DEWAX; throughout the night and another for stomata closing.	Waxes	10-13	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	84-89
24692420-7	2014	Cuticular wax biosynthesis is negatively regulated twice a day by the expression of DEWAX, throughout the night and at stomata closing.	Waxes	10-13	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	84-89
24562909-7	2014	In contrast, mammalian DGAT1 is more promiscuous regarding its substrates, producing diacylglycerol, retinyl esters, and waxes in addition to TAG.	Waxes	121-126	diacylglycerol O-acyltransferase 1	Homo sapiens	23-28
23384041-7	2013	In particular, whereas the cer2 mutation impaired the production of wax components longer than 28 carbons, the cer26 mutant was found to be affected in the production of wax components longer than 30 carbons.	Waxes	68-71	HXXXD-type acyl-transferase family protein	Arabidopsis thaliana	27-31
24014871-10	2013	In addition to the glassy trichome phenotype, the glh6 mutants showed defects in leaf cuticular wax, and glh6 was found to represent a new allele of the eceriferum 10 (cer10) mutation.	Waxes	96-99	3-oxo-5-alpha-steroid 4-dehydrogenase family protein	Arabidopsis thaliana	50-54
24330756-11	2013	A cDNA microarray chip assay revealed coordinated down regulation of genes encoding enzymes of the cuticular wax biosynthetic pathway in the glossy mutant, with BnCER1 being one of the most severely suppressed genes.	Waxes	109-112	protein ECERIFERUM 1	Brassica napus	161-167
24330756-12	2013	CONCLUSIONS: Our results indicated that surface wax biosynthesis is broadly affected in the glossy mutant due to the suppression of the BnCER1 and other wax-related genes.	Waxes	48-51	protein ECERIFERUM 1	Brassica napus	136-142
24330756-12	2013	CONCLUSIONS: Our results indicated that surface wax biosynthesis is broadly affected in the glossy mutant due to the suppression of the BnCER1 and other wax-related genes.	Waxes	153-156	protein ECERIFERUM 1	Brassica napus	136-142
23709630-9	2013	These results indicate that the regulatory cascade of MIXTA-like proteins and WIN1/SHN1 coordinately regulate cutin biosynthesis and wax accumulation.	Waxes	133-136	HOPW1-1-interacting 1	Arabidopsis thaliana	78-82
23709630-9	2013	These results indicate that the regulatory cascade of MIXTA-like proteins and WIN1/SHN1 coordinately regulate cutin biosynthesis and wax accumulation.	Waxes	133-136	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	83-87
23384041-7	2013	In particular, whereas the cer2 mutation impaired the production of wax components longer than 28 carbons, the cer26 mutant was found to be affected in the production of wax components longer than 30 carbons.	Waxes	170-173	HXXXD-type acyl-transferase family protein	Arabidopsis thaliana	111-116
21564271-10	2012	Application of wax solvent and MMA monomer to the ridge lap surfaces of the teeth gave the best results.	Waxes	15-18	LAP	Homo sapiens	56-59
22906826-3	2012	uNK cells in wax embedded sections were immunostained for CD56+ and expressed as a percentage of total stromal cells.	Waxes	13-16	unk zinc finger	Homo sapiens	0-3
22689894-0	2012	RDR1 and SGS3, components of RNA-mediated gene silencing, are required for the regulation of cuticular wax biosynthesis in developing inflorescence stems of Arabidopsis.	Waxes	103-106	RNA-dependent RNA polymerase 1	Arabidopsis thaliana	0-4
22689894-0	2012	RDR1 and SGS3, components of RNA-mediated gene silencing, are required for the regulation of cuticular wax biosynthesis in developing inflorescence stems of Arabidopsis.	Waxes	103-106	XS domain-containing protein / XS zinc finger domain-containing protein-like protein	Arabidopsis thaliana	9-13
22689894-3	2012	Recently, we have discovered a novel regulatory mechanism of cuticular wax biosynthesis that involves the ECERIFERUM7 (CER7) ribonuclease, a core subunit of the exosome.	Waxes	71-74	3'-5'-exoribonuclease family protein	Arabidopsis thaliana	106-117
22689894-3	2012	Recently, we have discovered a novel regulatory mechanism of cuticular wax biosynthesis that involves the ECERIFERUM7 (CER7) ribonuclease, a core subunit of the exosome.	Waxes	71-74	3'-5'-exoribonuclease family protein	Arabidopsis thaliana	119-123
22689894-4	2012	We hypothesized that at the onset of wax production, the CER7 ribonuclease degrades an mRNA specifying a repressor of CER3, a wax biosynthetic gene whose protein product is required for wax formation via the decarbonylation pathway.	Waxes	37-40	3'-5'-exoribonuclease family protein	Arabidopsis thaliana	57-61
22689894-4	2012	We hypothesized that at the onset of wax production, the CER7 ribonuclease degrades an mRNA specifying a repressor of CER3, a wax biosynthetic gene whose protein product is required for wax formation via the decarbonylation pathway.	Waxes	37-40	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	118-122
22689894-4	2012	We hypothesized that at the onset of wax production, the CER7 ribonuclease degrades an mRNA specifying a repressor of CER3, a wax biosynthetic gene whose protein product is required for wax formation via the decarbonylation pathway.	Waxes	126-129	3'-5'-exoribonuclease family protein	Arabidopsis thaliana	57-61
22689894-4	2012	We hypothesized that at the onset of wax production, the CER7 ribonuclease degrades an mRNA specifying a repressor of CER3, a wax biosynthetic gene whose protein product is required for wax formation via the decarbonylation pathway.	Waxes	126-129	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	118-122
22689894-6	2012	To identify the putative repressor of CER3 and to unravel the mechanism of CER7-mediated regulation of wax production, we performed a screen for suppressors of the cer7 mutant.	Waxes	103-106	3'-5'-exoribonuclease family protein	Arabidopsis thaliana	75-79
22791831-4	2012	Wax deposition on the inflorescence stem of cold-grown sfr3 plants was inhibited and the long-chain components of their leaf cuticular wax were reduced compared with wild-type plants.	Waxes	0-3	acetyl-CoA carboxylase 1	Arabidopsis thaliana	55-59
22891199-7	2012	The total cuticular wax load was reduced by approximately 13% and 20% in both ltpg2 and ltpg1 ltpg2 siliques, respectively, and by approximately 14% in ltpg1 ltpg2 stems when compared with the wild-type.	Waxes	20-23	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein	Arabidopsis thaliana	78-83
22891199-7	2012	The total cuticular wax load was reduced by approximately 13% and 20% in both ltpg2 and ltpg1 ltpg2 siliques, respectively, and by approximately 14% in ltpg1 ltpg2 stems when compared with the wild-type.	Waxes	20-23	glycosylphosphatidylinositol-anchored lipid protein transfer 1	Arabidopsis thaliana	88-93
22891199-7	2012	The total cuticular wax load was reduced by approximately 13% and 20% in both ltpg2 and ltpg1 ltpg2 siliques, respectively, and by approximately 14% in ltpg1 ltpg2 stems when compared with the wild-type.	Waxes	20-23	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein	Arabidopsis thaliana	94-99
22891199-7	2012	The total cuticular wax load was reduced by approximately 13% and 20% in both ltpg2 and ltpg1 ltpg2 siliques, respectively, and by approximately 14% in ltpg1 ltpg2 stems when compared with the wild-type.	Waxes	20-23	glycosylphosphatidylinositol-anchored lipid protein transfer 1	Arabidopsis thaliana	152-157
22891199-7	2012	The total cuticular wax load was reduced by approximately 13% and 20% in both ltpg2 and ltpg1 ltpg2 siliques, respectively, and by approximately 14% in ltpg1 ltpg2 stems when compared with the wild-type.	Waxes	20-23	Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin superfamily protein	Arabidopsis thaliana	94-99
21398568-6	2011	Microarray assays showed that a group of wax biosynthetic genes is upregulated in the activation-tagged myb96-1D mutant but downregulated in the MYB96-deficient myb96-1 mutant.	Waxes	41-44	myb domain protein 96	Arabidopsis thaliana	161-166
20542116-9	2010	Reconstitution of the wax biosynthetic pathway by heterologous expression of AmFAR1, together with Euglena wax synthase led to the high level production of medium to long chain wax monoesters in yeast.	Waxes	22-25	fatty acyl-CoA reductase 1	Apis mellifera	77-83
21398568-6	2011	Microarray assays showed that a group of wax biosynthetic genes is upregulated in the activation-tagged myb96-1D mutant but downregulated in the MYB96-deficient myb96-1 mutant.	Waxes	41-44	myb domain protein 96	Arabidopsis thaliana	104-109
21398568-6	2011	Microarray assays showed that a group of wax biosynthetic genes is upregulated in the activation-tagged myb96-1D mutant but downregulated in the MYB96-deficient myb96-1 mutant.	Waxes	41-44	myb domain protein 96	Arabidopsis thaliana	145-150
20732973-8	2010	Accumulations resembling the trilamellar lipidic coils in the abcg11 and abcg12 mutants defective in cuticular wax export were observed in the anther locules of abcg26 mutants.	Waxes	111-114	white-brown complex-like protein	Arabidopsis thaliana	62-68
20732973-8	2010	Accumulations resembling the trilamellar lipidic coils in the abcg11 and abcg12 mutants defective in cuticular wax export were observed in the anther locules of abcg26 mutants.	Waxes	111-114	ABC-2 type transporter family protein	Arabidopsis thaliana	73-79
20732973-8	2010	Accumulations resembling the trilamellar lipidic coils in the abcg11 and abcg12 mutants defective in cuticular wax export were observed in the anther locules of abcg26 mutants.	Waxes	111-114	ABC-2 type transporter family protein	Arabidopsis thaliana	161-167
20088377-2	2009	The Arabidopsis ATP binding cassette (ABC) transporter, Cer5, was found to be an exporter of wax molecules.	Waxes	93-96	ABC-2 type transporter family protein	Arabidopsis thaliana	56-60
19892830-6	2009	The CER1, CER4, WAX2 and SHN1 genes are known to be responsible for wax biosynthesis in Arabidopsis.	Waxes	68-71	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	4-8
19892830-6	2009	The CER1, CER4, WAX2 and SHN1 genes are known to be responsible for wax biosynthesis in Arabidopsis.	Waxes	68-71	Jojoba acyl CoA reductase-related male sterility protein	Arabidopsis thaliana	10-14
19892830-6	2009	The CER1, CER4, WAX2 and SHN1 genes are known to be responsible for wax biosynthesis in Arabidopsis.	Waxes	68-71	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	16-20
19892830-6	2009	The CER1, CER4, WAX2 and SHN1 genes are known to be responsible for wax biosynthesis in Arabidopsis.	Waxes	68-71	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	25-29
20237894-5	2010	Here, we characterize lacs1 mutants of Arabidopsis that reveals a role for LACS1 in biosynthesis of cuticular wax components.	Waxes	110-113	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	22-27
20237894-5	2010	Here, we characterize lacs1 mutants of Arabidopsis that reveals a role for LACS1 in biosynthesis of cuticular wax components.	Waxes	110-113	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	75-80
19392700-3	2009	Mutations in LACS1 reduced the amount of wax in all chemical classes on the stem and leaf, except in the very long-chain fatty acid (VLCFA) class wherein acids longer than 24 carbons (C(24)) were elevated more than 155%.	Waxes	41-44	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	13-18
19392700-10	2009	As such, LACS1 defines a functionally novel acyl-CoA synthetase that preferentially modifies both VLCFAs for wax synthesis and long-chain (C(16)) fatty acids for cutin synthesis.	Waxes	109-112	AMP-dependent synthetase and ligase family protein	Arabidopsis thaliana	9-14
19141401-4	2008	The presence of MMP-9 in cancer tissue was investigated by immunohistochemistry on formalin-fixed, wax-embedded sections of esophageal cancers.	Waxes	99-102	matrix metallopeptidase 9	Homo sapiens	16-21
18072759-3	2008	On the wax surface, a single C18 molecule and clusters were preferably deposited on the wax surface (010) in a parallel conformation, which resulted in the formation of large blocks of wax crystal.	Waxes	7-10	Bardet-Biedl syndrome 9	Homo sapiens	29-32
19322663-6	2009	OsGL1-4, -5, -6, and -7 are closely related to Arabidopsis CER1 that is involved in cuticular wax biosynthesis.	Waxes	94-97	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	59-63
19346242-5	2009	In the mah1 mutant stem wax, diols and ketols could not be detected, while the amounts of secondary alcohols and ketones were drastically reduced.	Waxes	24-27	cytochrome P450, family 96, subfamily A, polypeptide 15	Arabidopsis thaliana	7-11
17727615-2	2007	Arabidopsis wbc11 T-DNA insertional knock-out mutants exhibited lipidic inclusions inside epidermal cells similar to the previously characterized wax transporter mutant cer5, with a similar strong reduction in the alkanes of surface waxes.	Waxes	233-238	white-brown complex-like protein	Arabidopsis thaliana	12-17
17905869-3	2007	Here, we used a reverse-genetic approach to identify a cytochrome P450 enzyme (CYP96A15) involved in wax biosynthesis and characterized it as a midchain alkane hydroxylase (MAH1).	Waxes	101-104	cytochrome P450, family 96, subfamily A, polypeptide 15	Arabidopsis thaliana	79-87
17905869-3	2007	Here, we used a reverse-genetic approach to identify a cytochrome P450 enzyme (CYP96A15) involved in wax biosynthesis and characterized it as a midchain alkane hydroxylase (MAH1).	Waxes	101-104	cytochrome P450, family 96, subfamily A, polypeptide 15	Arabidopsis thaliana	173-177
17624331-2	2007	The Arabidopsis CER3 gene is important for cuticular wax biosynthesis and was reported to correspond to At5g02310 encoding an E3 ubiquitin ligase.	Waxes	53-56	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	16-20
16980563-0	2006	CER4 encodes an alcohol-forming fatty acyl-coenzyme A reductase involved in cuticular wax production in Arabidopsis.	Waxes	86-89	Jojoba acyl CoA reductase-related male sterility protein	Arabidopsis thaliana	0-4
17496107-8	2007	These results strongly suggest that GPAT5 functions in vivo as an acyltransferase to a glycerol-containing acceptor and has access to the same pool of acyl intermediates and/or may be targeted to the same membrane domain as that of wax synthesis in aerial organs.	Waxes	232-235	glycerol-3-phosphate acyltransferase 5	Arabidopsis thaliana	36-41
17513515-5	2007	Fluorescence in situ hybridisation analysis performed on paraffin-wax-embedded tumour tissue revealed a mixed-lineage leukaemia (MLL) gene rearrangement, supporting the association of this malignancy with prior chemotherapy.	Waxes	66-69	lysine methyltransferase 2A	Homo sapiens	104-127
17513515-5	2007	Fluorescence in situ hybridisation analysis performed on paraffin-wax-embedded tumour tissue revealed a mixed-lineage leukaemia (MLL) gene rearrangement, supporting the association of this malignancy with prior chemotherapy.	Waxes	66-69	lysine methyltransferase 2A	Homo sapiens	129-132
17351114-2	2007	The Arabidopsis thaliana cer7 mutant exhibits reduced cuticular wax accumulation and contains considerably lower transcript levels of ECERIFERUM3/WAX2/YORE-YORE (CER3/WAX2/YRE), a key wax biosynthetic gene.	Waxes	64-67	3'-5'-exoribonuclease family protein	Arabidopsis thaliana	25-29
16106050-0	2005	A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters.	Waxes	94-99	acyl-CoA wax alcohol acyltransferase 2	Homo sapiens	13-46
16601094-10	2006	When compared with controls, sections of wax embedded lung tissue from patients with ALI showed greater positive staining for thioredoxin in alveolar macrophages and type II epithelial cells.	Waxes	41-44	thioredoxin	Homo sapiens	126-137
15834126-0	2005	The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters.	Waxes	92-97	diacylglycerol O-acyltransferase 1	Mus musculus	37-42
16183838-6	2005	These results indicate that rst1 causes shunting of most wax precursors away from alkane synthesis and into the primary-alcohol-producing branch of the pathway.	Waxes	57-60	ARM repeat superfamily protein	Arabidopsis thaliana	28-32
15499022-5	2004	We found that the CER5 gene encodes an ABC transporter localized in the plasma membrane of epidermal cells and conclude that it is required for wax export to the cuticle.	Waxes	144-147	ABC-2 type transporter family protein	Arabidopsis thaliana	18-22
15671038-6	2005	All four gene products mediate the synthesis of triacylglycerol; however, two of the X-linked genes act as acyl-CoA wax alcohol acyltransferases (AWAT 1 and 2) that predominantly esterify long chain (wax) alcohols with acyl-CoA-derived fatty acids to produce wax esters.	Waxes	199-204	acyl-CoA wax alcohol acyltransferase 1	Homo sapiens	146-158
15849306-6	2005	Indeed, in addition to affecting cuticular wax biosynthesis, gl1 mutations have a pleiotropic effect on epidermis development, altering trichome size and impairing cutin structure.	Waxes	43-46	glossy 1	Zea mays	61-64
15499022-5	2004	We found that the CER5 gene encodes an ABC transporter localized in the plasma membrane of epidermal cells and conclude that it is required for wax export to the cuticle.	Waxes	144-147	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	39-54
15070782-0	2004	WIN1, a transcriptional activator of epidermal wax accumulation in Arabidopsis.	Waxes	47-50	HOPW1-1-interacting 1	Arabidopsis thaliana	0-4
15070782-3	2004	We constitutively expressed WIN1 in transgenic Arabidopsis plants, and found that leaf epidermal wax accumulation was up to 4.5-fold higher in these plants than in control plants.	Waxes	97-100	HOPW1-1-interacting 1	Arabidopsis thaliana	28-32
12671095-8	2003	The total wax load of fatb-ko plants was reduced by 20% in leaves and by 50% in stems, implicating FATB in the supply of saturated fatty acids for wax biosynthesis.	Waxes	10-13	fatty acyl-ACP thioesterases B	Arabidopsis thaliana	22-26
12724542-4	2003	The total wax amount on wax2 leaves and stems was reduced by >78% and showed proportional deficiencies in the aldehydes, alkanes, secondary alcohols, and ketones, with increased acids, primary alcohols, and esters.	Waxes	10-13	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	24-28
12724542-11	2003	Based on these analyses, we predict that WAX2 has a metabolic function associated with both cuticle membrane and wax synthesis.	Waxes	113-116	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	41-45
12974811-9	2003	Double mutants of yre and trichome-morphology mutants, glabra2 (gl2) and transparent testa glabra1 (ttg1), showed that the phenotype of the trichome structure was additive, suggesting that the wax-requiring pathway is distinct from the trichome development pathway controlled by GL2 and TTG1.	Waxes	193-196	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	100-104
12974811-9	2003	Double mutants of yre and trichome-morphology mutants, glabra2 (gl2) and transparent testa glabra1 (ttg1), showed that the phenotype of the trichome structure was additive, suggesting that the wax-requiring pathway is distinct from the trichome development pathway controlled by GL2 and TTG1.	Waxes	193-196	HD-ZIP IV family of homeobox-leucine zipper protein with lipid-binding START domain-containing protein	Arabidopsis thaliana	279-282
12974811-9	2003	Double mutants of yre and trichome-morphology mutants, glabra2 (gl2) and transparent testa glabra1 (ttg1), showed that the phenotype of the trichome structure was additive, suggesting that the wax-requiring pathway is distinct from the trichome development pathway controlled by GL2 and TTG1.	Waxes	193-196	Transducin/WD40 repeat-like superfamily protein	Arabidopsis thaliana	287-291
12671095-8	2003	The total wax load of fatb-ko plants was reduced by 20% in leaves and by 50% in stems, implicating FATB in the supply of saturated fatty acids for wax biosynthesis.	Waxes	10-13	fatty acyl-ACP thioesterases B	Arabidopsis thaliana	99-103
12100148-5	2002	IL-6 expression was determined on paraffin-wax sections of biopsy material by means of an immunohistochemical assay.	Waxes	43-46	interleukin 6	Homo sapiens	0-4
12177469-1	2002	To learn more about the role of the CER6 condensing enzyme in Arabidopsis surface wax production, we determined CER6 transcription domains and the timing of CER6 transcription in vegetative and reproductive structures from juvenile, mature, and senescing tissues.	Waxes	82-85	3-ketoacyl-CoA synthase 6	Arabidopsis thaliana	36-40
12364560-1	2002	Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids, mainly oleate (18:1) and palmitoleate (16:1), which are the major monounsaturated fatty acids of membrane phospholipids, cholesteryl esters, waxes, and triglycerides.	Waxes	262-267	stearoyl-Coenzyme A desaturase 1	Mus musculus	25-28
9421476-7	1998	In line with these results, epidermal lipid analysis showed that the relative amounts of the sebum components TG and wax diesters in the epidermis of high expressor APOC1 transgenic mice were reduced by 60 and 45%, respectively.	Waxes	117-120	apolipoprotein C-I	Mus musculus	165-170
11396956-1	2001	Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids mainly oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, cholesterol esters, waxes, and triglycerides.	Waxes	262-267	stearoyl-CoA desaturase	Homo sapiens	0-23
11396956-1	2001	Stearoyl-CoA desaturase (SCD) catalyzes the rate-limiting step in the cellular synthesis of monounsaturated fatty acids mainly oleate (C18:1) and palmitoleate (C16:1) which are the major monounsaturated fatty acids of membrane phospholipids, cholesterol esters, waxes, and triglycerides.	Waxes	262-267	stearoyl-CoA desaturase	Homo sapiens	25-28
11171137-7	2000	Our results indicate that ACL generates the cytosolic pool of acetyl-CoA, which is the substrate required for the biosynthesis of a variety of phytochemicals, including cuticular waxes and flavonoids.	Waxes	179-184	acetone-cyanohydrin lyase	Arabidopsis thaliana	26-29
10330468-9	1999	This result indicates that CUT1 is involved in the production of VLCFA precursors used for the synthesis of all stem wax components in Arabidopsis.	Waxes	117-120	3-ketoacyl-CoA synthase 6	Arabidopsis thaliana	27-31
9851689-7	1998	The antibodies were used to detect, by immunohistochemistry, activated MMP-9 in formalin-fixed, wax-embedded sections from a series of oesophageal cancer cases previously shown to contain MMP-9.	Waxes	96-99	matrix metallopeptidase 9	Homo sapiens	71-76
9851689-9	1998	As the antibodies are effective in immunohistochemistry on formalin-fixed, wax-embedded sections, they should prove useful for the detection of activated MMP-9 in various disease processes.	Waxes	75-78	matrix metallopeptidase 9	Homo sapiens	154-159
9342868-7	1997	This finding suggests that the GL8 protein probably functions as a reductase during fatty acid elongation in the cuticular wax biosynthetic pathway.	Waxes	123-126	glossy 8	Zea mays	31-34
8811860-1	1996	The eceriferum3 (cer3) locus encodes one of 21 gene products known to be involved in wax biosynthesis in Arabidopsis thaliana.	Waxes	85-88	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	4-15
9351246-7	1997	The MS2 gene product shows sequence similarity to a jojoba protein that converts wax fatty acids to fatty alcohols.	Waxes	81-84	Jojoba acyl CoA reductase-related male sterility protein	Arabidopsis thaliana	4-7
8811860-1	1996	The eceriferum3 (cer3) locus encodes one of 21 gene products known to be involved in wax biosynthesis in Arabidopsis thaliana.	Waxes	85-88	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	17-21
8597958-5	1996	Our monoclonal antibody was prepared against a synthetic peptide corresponding to an amino acid sequence specific for MMP-1 and was selected to react in formalin-fixed wax-embedded sections, thus allowing use in diagnostic histopathology and also enabling access to archival material.	Waxes	168-171	matrix metallopeptidase 1	Homo sapiens	118-123
8245417-2	1993	We developed an effective new method to retain CSA antigenicity with good morphology of embryonic tissues by using microwave irradiation (MWI) for pre-fixation, 95% ethanol/1% acetic acid as post-fixative solution, and polyester wax as embedding material.	Waxes	229-232	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	47-50
8181636-8	1994	The distribution of wax hydrocarbons (principally n-alkanes) in the confectionery coincided exactly with that for the paper wrapping, with a range of C23 to C33 (95% material) centred around C26.	Waxes	20-23	nucleolin	Homo sapiens	150-153
7671414-1	1995	Twenty cases of solar keratosis and 15 cases of Bowen"s disease were investigated for the expression of transforming growth factor alpha (TGF-alpha) by an indirect immunoperoxidase technique using monoclonal antibody TGF-alpha AB-2 in formalin-fixed wax-embedded tissue.	Waxes	250-253	transforming growth factor alpha	Homo sapiens	138-147
1908078-3	1991	For immunohistochemistry, an indirect immunoperoxidase method was chosen to detect P29 in methacarn-fixed, wax-embedded sections.	Waxes	107-110	SYF2 pre-mRNA splicing factor	Homo sapiens	83-86
8514278-0	1993	Detection of the Ki-67 antigen in fixed and wax-embedded sections with the monoclonal antibody MIB1.	Waxes	44-47	antigen identified by monoclonal antibody Ki 67	Mus musculus	17-22
6291659-1	1982	The interaction of cytochrome c with a paraffin-wax-impregnated spectroscopic graphite electrode (WISGE) was studied in a medium consisting of 0.1 M potassium phosphate, pH 7.0, by means of differential pulse and cyclic voltammetry.	Waxes	48-51	cytochrome c, somatic	Equus caballus	19-31
32796756-4	2020	Beeswax organogels with and without curcumin, with a beta" orthorhombic subcell structure, showed a predominant elastic behavior and a melting event wider and shifted to lower temperatures than pure beeswax, suggesting a plasticizer effect of the oil in the wax crystals.	Waxes	4-7	amyloid beta precursor protein	Homo sapiens	51-57
34827180-7	2021	We then used this procedure to show that Kr-h1 mediates the influence of JH, not only on oogenesis and wax production, but also on aggression and dominance rank.	Waxes	103-106	kruppel homolog 1	Bombus terrestris	41-46
34764971-10	2021	Co-expression of AtARRE and candidate target proteins involved in alkane formation in both Nicotiana benthamiana and stable Arabidopsis transgenic lines demonstrated that AtARRE controls the levels of wax biosynthetic enzymes ECERIFERUM1 (CER1) and ECERIFERUM3 (CER3).	Waxes	201-204	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	226-237
34764971-10	2021	Co-expression of AtARRE and candidate target proteins involved in alkane formation in both Nicotiana benthamiana and stable Arabidopsis transgenic lines demonstrated that AtARRE controls the levels of wax biosynthetic enzymes ECERIFERUM1 (CER1) and ECERIFERUM3 (CER3).	Waxes	201-204	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	239-243
34764971-10	2021	Co-expression of AtARRE and candidate target proteins involved in alkane formation in both Nicotiana benthamiana and stable Arabidopsis transgenic lines demonstrated that AtARRE controls the levels of wax biosynthetic enzymes ECERIFERUM1 (CER1) and ECERIFERUM3 (CER3).	Waxes	201-204	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	249-260
34764971-10	2021	Co-expression of AtARRE and candidate target proteins involved in alkane formation in both Nicotiana benthamiana and stable Arabidopsis transgenic lines demonstrated that AtARRE controls the levels of wax biosynthetic enzymes ECERIFERUM1 (CER1) and ECERIFERUM3 (CER3).	Waxes	201-204	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	262-266
34113821-5	2021	In these mice, specific meibum lipid classes were reduced: (O-acyl)-omega-hydroxy fatty acids and type 1omega wax diesters in Awat1 KO mice, wax monoesters and types 1omega and 2omega wax diesters in Awat2 KO mice, and most of these in DKO mice.	Waxes	110-113	acyl-CoA wax alcohol acyltransferase 1	Mus musculus	126-131
1826643-3	1991	In routinely processed, wax-embedded tissues, using a standard immunocytochemical technique, PGP9.5 polyclonal antibody specifically demonstrated the developing nervous system and primitive adrenal chromaffin cells.	Waxes	24-27	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	93-99
35566955-5	2022	When 6 g/m2 of microcrystalline wax was applied to the surface of starch pretreated paper, the kit rating value of the paper was high, at up to 10/12, the Cobb60 value decreased to 12.5 g/m2, the overall migration of paper was less than 10 mg/dm2, and the water vapor permeability was reduced by 81.9%, which met the requirements of oil and water resistance performance of food packaging paper.	Waxes	32-35	immunoglobulin heavy diversity 1-14 (non-functional)	Homo sapiens	243-246
33037987-0	2021	The 3-ketoacyl-CoA synthase WFL is involved in lateral organ development and cuticular wax synthesis in Medicago truncatula.	Waxes	87-90	3-ketoacyl-CoA synthase 4	Medicago truncatula	4-27
33672591-3	2021	Hot extraction of n-hexane was carried out, followed by separation of the part insoluble in methanol: wax (WA-hex), from the part soluble in methanol (ME-hex).	Waxes	102-105	hematopoietically expressed homeobox	Homo sapiens	110-113
1120137-2	1975	Fatty acids of wax and sterol esters were predominantly even chain monounsaturates (63 per cent) between C16 and C36 with a surprisingly high proportion of long chain lengths: the principal peaks corresponded to C32, C34, C18, C30, and C22 monoenes.	Waxes	15-18	chemokine-like factor	Mus musculus	212-215
1120137-2	1975	Fatty acids of wax and sterol esters were predominantly even chain monounsaturates (63 per cent) between C16 and C36 with a surprisingly high proportion of long chain lengths: the principal peaks corresponded to C32, C34, C18, C30, and C22 monoenes.	Waxes	15-18	Sp7 transcription factor 7	Mus musculus	236-239
33945542-8	2021	Keeping this fact in mind a wax biosynthetic gene CER3, from Arabidopsis thaliana was transformed into G. hirsutum and the plants were evaluated for their resistance against whitefly and CLCuV transmission.	Waxes	28-31	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	50-54
33557073-6	2021	Gas Chromatography-Mass Spectroscopy (GC-MS) analysis identified a characteristic decrease in the accumulation of certain waxes (e.g., alkanes, alcohols) in Arabidopsis cuticles under cold acclimation, which was additionally reduced in cer3-6.	Waxes	122-127	Fatty acid hydroxylase superfamily	Arabidopsis thaliana	236-242
33129252-13	2020	CONCLUSIONS: WRI4-like gene from Cyperus esculentus improves drought tolerance in Arabidopsis probably by promoting cuticular wax biosynthesis and deposition.	Waxes	126-129	Integrase-type DNA-binding superfamily protein	Arabidopsis thaliana	13-17
33087416-0	2020	ELONGATED HYPOCOTYL5 negatively regulates DECREASE WAX BIOSYNTHESIS to increase survival during UV-B stress.	Waxes	51-54	Basic-leucine zipper (bZIP) transcription factor family protein	Arabidopsis thaliana	10-20