PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25206404-8	2013	These effects of eleutheroside B or E may be mediated by activation of cholinesterase or enhanced reuse of choline to accelerate the synthesis of acetylcholine in hippocampal neurons.	syringin	17-32	butyrylcholinesterase	Rattus norvegicus	71-85
35580997-11	2022	Further elucidation of the mechanism revealed that Eleutheroside B induced mitochondrial dysfunction, with mitochondrial membrane potential collapse and cytochrome c release, suggesting that Eleutheroside B induced apoptosis by triggering mitochondrial pathway.	syringin	51-66	cytochrome c, somatic	Homo sapiens	153-165
34585457-0	2021	Eleutheroside B-loaded poly (lactic-co-glycolic acid) nanoparticles protect against renal fibrosis via Smad3-dependent mechanism.	syringin	0-15	SMAD family member 3	Mus musculus	103-108
34585457-4	2021	In vitro and in vivo results showed that eleutheroside B could inhibit expression levels of alpha-smooth muscle actin (alpha-SMA) and collagen I. Molecular docking results showed that eleutheroside B bound to Smad3 and significantly decreased the expression of phospho-Smad3 (p-Smad3).	syringin	41-56	actin alpha 2, smooth muscle, aorta	Mus musculus	119-128
34585457-4	2021	In vitro and in vivo results showed that eleutheroside B could inhibit expression levels of alpha-smooth muscle actin (alpha-SMA) and collagen I. Molecular docking results showed that eleutheroside B bound to Smad3 and significantly decreased the expression of phospho-Smad3 (p-Smad3).	syringin	41-56	SMAD family member 3	Mus musculus	209-214
34585457-4	2021	In vitro and in vivo results showed that eleutheroside B could inhibit expression levels of alpha-smooth muscle actin (alpha-SMA) and collagen I. Molecular docking results showed that eleutheroside B bound to Smad3 and significantly decreased the expression of phospho-Smad3 (p-Smad3).	syringin	41-56	SMAD family member 3	Mus musculus	278-283
34585457-4	2021	In vitro and in vivo results showed that eleutheroside B could inhibit expression levels of alpha-smooth muscle actin (alpha-SMA) and collagen I. Molecular docking results showed that eleutheroside B bound to Smad3 and significantly decreased the expression of phospho-Smad3 (p-Smad3).	syringin	184-199	actin alpha 2, smooth muscle, aorta	Mus musculus	119-128
34585457-4	2021	In vitro and in vivo results showed that eleutheroside B could inhibit expression levels of alpha-smooth muscle actin (alpha-SMA) and collagen I. Molecular docking results showed that eleutheroside B bound to Smad3 and significantly decreased the expression of phospho-Smad3 (p-Smad3).	syringin	184-199	SMAD family member 3	Mus musculus	209-214
34585457-4	2021	In vitro and in vivo results showed that eleutheroside B could inhibit expression levels of alpha-smooth muscle actin (alpha-SMA) and collagen I. Molecular docking results showed that eleutheroside B bound to Smad3 and significantly decreased the expression of phospho-Smad3 (p-Smad3).	syringin	184-199	SMAD family member 3	Mus musculus	278-283
34585457-5	2021	Silencing Smad3 reversed the fibrotic protective effect of eleutheroside B in HK2 cells.	syringin	59-74	SMAD family member 3	Mus musculus	10-15
33971494-0	2021	Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF-kappaB/NLRP3 and PGC1a/SIRT3 pathways.	syringin	45-53	toll-like receptor 4	Rattus norvegicus	105-109
33971494-0	2021	Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF-kappaB/NLRP3 and PGC1a/SIRT3 pathways.	syringin	45-53	NLR family, pyrin domain containing 3	Rattus norvegicus	120-125
33971494-0	2021	Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF-kappaB/NLRP3 and PGC1a/SIRT3 pathways.	syringin	45-53	PPARG coactivator 1 alpha	Rattus norvegicus	130-135
33971494-0	2021	Synergistic cardioptotection by tilianin and syringin in diabetic cardiomyopathy involves interaction of TLR4/NF-kappaB/NLRP3 and PGC1a/SIRT3 pathways.	syringin	45-53	sirtuin 3	Rattus norvegicus	136-141
35580997-11	2022	Further elucidation of the mechanism revealed that Eleutheroside B induced mitochondrial dysfunction, with mitochondrial membrane potential collapse and cytochrome c release, suggesting that Eleutheroside B induced apoptosis by triggering mitochondrial pathway.	syringin	191-206	cytochrome c, somatic	Homo sapiens	153-165
31899146-6	2020	Syringin inhibited DSS or LPS-induced overproduction of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and proinflammatory substances (iNOS, COX-2).	syringin	0-8	interleukin 1 beta	Rattus norvegicus	83-91
31899146-6	2020	Syringin inhibited DSS or LPS-induced overproduction of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and proinflammatory substances (iNOS, COX-2).	syringin	0-8	interleukin 6	Rattus norvegicus	93-97
31899146-6	2020	Syringin inhibited DSS or LPS-induced overproduction of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and proinflammatory substances (iNOS, COX-2).	syringin	0-8	tumor necrosis factor	Rattus norvegicus	99-108
31899146-6	2020	Syringin inhibited DSS or LPS-induced overproduction of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and proinflammatory substances (iNOS, COX-2).	syringin	0-8	nitric oxide synthase 2	Rattus norvegicus	142-146
31899146-6	2020	Syringin inhibited DSS or LPS-induced overproduction of proinflammatory cytokines (IL-1beta, IL-6, TNF-alpha) and proinflammatory substances (iNOS, COX-2).	syringin	0-8	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	148-153
31899146-8	2020	The activation of antioxidant Nrf2 signaling pathway was promoted by syringin.	syringin	69-77	NFE2 like bZIP transcription factor 2	Rattus norvegicus	30-34
31899146-11	2020	Taken together, our results suggest that syringin shows protective effects on intestinal inflammation through inhibiting NF-kappaB, while activating Nrf2 signaling pathway in colitis.	syringin	41-49	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
31784933-10	2021	Compared with the model group, fluoxetine and geniposide + eleutheroside B administration significantly improved the immobility time of depressed mice in the FST and TST, decreased serum IL-1 beta content, inhibited the expression levels of NF- kappa B gene and protein in hippocampus tissues (P<0.05 or P<0.01).	syringin	59-74	interleukin 1 beta	Mus musculus	187-196
31784933-10	2021	Compared with the model group, fluoxetine and geniposide + eleutheroside B administration significantly improved the immobility time of depressed mice in the FST and TST, decreased serum IL-1 beta content, inhibited the expression levels of NF- kappa B gene and protein in hippocampus tissues (P<0.05 or P<0.01).	syringin	59-74	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	241-252
31784933-11	2021	Compared with the model group, geniposide + eleutheroside B treatment significantly reduced serum TNF-alpha content and inhibited IDO mRNA and protein expressions in hippocampus (P<0.05 or P<0.01).	syringin	44-59	tumor necrosis factor	Mus musculus	98-107
31784933-11	2021	Compared with the model group, geniposide + eleutheroside B treatment significantly reduced serum TNF-alpha content and inhibited IDO mRNA and protein expressions in hippocampus (P<0.05 or P<0.01).	syringin	44-59	indoleamine 2,3-dioxygenase 1	Mus musculus	130-133
31784933-12	2021	In addition, NMDA partly prevented the inhibition of IDO mRNA expression by geniposide + eleutheroside B; NMDA and WAY-100635 also partly prevented the reduction of IL-1 ss content induced by geniposide + eleutheroside B treatment (P<0.05 or P<0.01).	syringin	89-104	indoleamine 2,3-dioxygenase 1	Mus musculus	53-56
31661774-5	2019	MTT assay was used to detect the effect of eleutheroside B on proliferation of human HK-2 cells in presence and in absence of cisplatin.	syringin	43-58	hexokinase 2	Homo sapiens	85-89
31661774-10	2019	Periodic acid-Schiff staining and Western blot analysis of KIM-1 showed that eleutheroside B alleviated tubular cell injury.	syringin	77-92	hepatitis A virus cellular receptor 1	Homo sapiens	59-64
31661774-11	2019	Further, eleutheroside B reduced macrophage infiltration and production of inflammatory cytokines, inhibited the activation of nuclear factor (NF)-kappaB, and inhibited apoptosis and programmed necrosis.	syringin	9-24	nuclear factor kappa B subunit 1	Homo sapiens	127-153
31661774-12	2019	The mechanism may be that eleutheroside B can activate the insulin-like growth factor (IGF) pathway and its downstream pathway by downregulating the expression of IGFBP-7, thus promoting cell proliferation.	syringin	26-41	insulin like growth factor binding protein 7	Homo sapiens	163-170