PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2481486-0	1989	Monoclonal antibody 3F8 recognises the neural cell adhesion molecule (NCAM) in addition to the ganglioside GD2.	Gangliosides	95-106	retinoic acid induced 2	Mus musculus	20-23
2481486-1	1989	The monoclonal antibody 3F8 has been described as binding to the ganglioside GD2.	Gangliosides	65-76	retinoic acid induced 2	Mus musculus	24-27
2480129-1	1989	Rabbit myelin basic protein (MBP) was phosphorylated by a ganglioside-stimulated protein kinase to a stoichiometry of 1.4 and 2.1 mol phosphate/mol MBP in the presence and absence of GTlb, respectively.	Gangliosides	58-69	myelin basic protein	Oryctolagus cuniculus	7-27
2600976-0	1989	EGF-induced neuritogenesis and correlated synthesis of plasma membrane gangliosides in cultured embryonic chick CNS neurons.	Gangliosides	71-83	epidermal growth factor	Gallus gallus	0-3
2600976-6	1989	When the undifferentiated neurons in serum-free medium are exposed to EGF, the ensuing generation of neurite plasma membrane coincides with initiation of biosynthesis of the sialosyl gangliotetraosyl ceramide species of gangliosides (GD1A, GD1B, GT1B, GQ1B).	Gangliosides	220-232	epidermal growth factor	Gallus gallus	70-73
2600976-7	1989	Antibody to EGF simultaneously inhibits biosynthesis of these gangliosides as well as inhibition of neuritogenesis.	Gangliosides	62-74	epidermal growth factor	Gallus gallus	12-15
2480129-1	1989	Rabbit myelin basic protein (MBP) was phosphorylated by a ganglioside-stimulated protein kinase to a stoichiometry of 1.4 and 2.1 mol phosphate/mol MBP in the presence and absence of GTlb, respectively.	Gangliosides	58-69	myelin basic protein	Oryctolagus cuniculus	29-32
2480129-1	1989	Rabbit myelin basic protein (MBP) was phosphorylated by a ganglioside-stimulated protein kinase to a stoichiometry of 1.4 and 2.1 mol phosphate/mol MBP in the presence and absence of GTlb, respectively.	Gangliosides	58-69	myelin basic protein	Oryctolagus cuniculus	148-151
2480129-2	1989	Two-dimensional peptide mapping analyses revealed that two of the sites of phosphorylation were distinct from those catalyzed by cAMP-dependent protein kinase or protein kinase C. Phosphorylation of one of these sites by ganglioside-stimulated protein kinase was inhibited by GTlb, suggesting that the inhibitory effect of gangliosides on MBP phosphorylation may be substrate-directed.	Gangliosides	221-232	myelin basic protein	Oryctolagus cuniculus	339-342
2480129-2	1989	Two-dimensional peptide mapping analyses revealed that two of the sites of phosphorylation were distinct from those catalyzed by cAMP-dependent protein kinase or protein kinase C. Phosphorylation of one of these sites by ganglioside-stimulated protein kinase was inhibited by GTlb, suggesting that the inhibitory effect of gangliosides on MBP phosphorylation may be substrate-directed.	Gangliosides	323-335	myelin basic protein	Oryctolagus cuniculus	339-342
2547442-6	1989	These findings suggest that the predominant binding substance on neuraminidase-treated human type B erythrocytes for the LTc-B is ganglioside GM1 and that the combining site of LTc-B may be specific for the terminal disaccharide (galactose-N-acetyl-D-galactosamine)-linked portion of ganglioside GM1.	Gangliosides	130-141	neuraminidase 1	Homo sapiens	65-78
2627112-2	1989	In the present study, the analysis of gangliosides from two tumorigenic sublines obtained after transfection of the TGr II cell line HCV 29 with the v-raf-oncogene, provided further evidence for the inverse relationship between tumorigenicity and the GM2 ganglioside expression.	Gangliosides	38-50	thioredoxin reductase 3	Homo sapiens	116-119
2678480-2	1989	MoAb 3F8 is a murine IgG3 antibody specific for the ganglioside GD2.	Gangliosides	52-63	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	21-25
2583186-0	1989	The activity of GD3 synthase modulates the ganglioside pattern in rat liver.	Gangliosides	43-54	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	16-28
2583186-1	1989	Variations of the ganglioside composition in the livers of Wistar rats correlated with the activity of GD3 synthase in the corresponding liver homogenates.	Gangliosides	18-29	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	103-115
2695376-3	1989	The major gangliosides detected in glycolipid extracts of whole human pancreas were GM3, GD3 (disialoganglioside), and in a lesser amount, a GD1a-comigrating ganglioside.	Gangliosides	10-22	GRDX	Homo sapiens	89-92
2695376-3	1989	The major gangliosides detected in glycolipid extracts of whole human pancreas were GM3, GD3 (disialoganglioside), and in a lesser amount, a GD1a-comigrating ganglioside.	Gangliosides	10-21	GRDX	Homo sapiens	89-92
2478163-2	1989	Subsequent addition of fetal calf serum or bovine and human serum albumin blocked GM1 action on CD4 expression, most likely through the formation of ganglioside-albumin complexes.	Gangliosides	149-160	CD4 molecule	Bos taurus	96-99
2759093-3	1989	The absence of ganglioside sialidase activity in sialidosis patients indicates that lysosomal sialidase is active towards gangliosides and glycoproteins.	Gangliosides	122-134	neuraminidase 1	Homo sapiens	84-103
2547442-6	1989	These findings suggest that the predominant binding substance on neuraminidase-treated human type B erythrocytes for the LTc-B is ganglioside GM1 and that the combining site of LTc-B may be specific for the terminal disaccharide (galactose-N-acetyl-D-galactosamine)-linked portion of ganglioside GM1.	Gangliosides	284-295	neuraminidase 1	Homo sapiens	65-78
2472199-11	1989	The binding of the antibodies to melanoma cell surface gangliosides was confirmed by an absorption with a GD3- and O-AcGD3-positive melanoma cell line.	Gangliosides	55-67	GRDX	Homo sapiens	106-109
2779846-1	1989	Immunohistochemical localization of ganglioside GM1 using 3 monoclonal antibodies (C3 and D3 reacting exclusively with GM1 and C4h2 reacting also with other gangliosides) showed different staining patterns in rat brain regions (cerebellum, cerebral cortex and hippocampus).	Gangliosides	36-47	complement C3	Rattus norvegicus	83-92
2472199-0	1989	An epitope common to gangliosides O-acetyl-GD3 and GD3 recognized by antibodies in melanoma patients after active specific immunotherapy.	Gangliosides	21-33	GRDX	Homo sapiens	43-46
2757685-2	1989	Five gangliosides were identified in cells isolated from the external musculo-elastic intimal layer adjacent to the media: GM3, GM1, GD3, GD1a, and GT1b.	Gangliosides	5-17	GRDX	Homo sapiens	133-136
2472199-0	1989	An epitope common to gangliosides O-acetyl-GD3 and GD3 recognized by antibodies in melanoma patients after active specific immunotherapy.	Gangliosides	21-33	GRDX	Homo sapiens	51-54
2472199-1	1989	GD3 is a major ganglioside of human melanoma and was shown to be an effective target for passive immunotherapy with murine monoclonal antibodies.	Gangliosides	15-26	GRDX	Homo sapiens	0-3
2472199-3	1989	In this study, we demonstrate that melanoma patients who received MCV had autoantibodies against a derivative of GD3, O-acetylated GD3 (O-AcGD3), a minor ganglioside expressed on human melanoma cells, and that the antibodies cross-reacted with GD3.	Gangliosides	154-165	GRDX	Homo sapiens	113-116
2472199-3	1989	In this study, we demonstrate that melanoma patients who received MCV had autoantibodies against a derivative of GD3, O-acetylated GD3 (O-AcGD3), a minor ganglioside expressed on human melanoma cells, and that the antibodies cross-reacted with GD3.	Gangliosides	154-165	GRDX	Homo sapiens	131-134
2472199-3	1989	In this study, we demonstrate that melanoma patients who received MCV had autoantibodies against a derivative of GD3, O-acetylated GD3 (O-AcGD3), a minor ganglioside expressed on human melanoma cells, and that the antibodies cross-reacted with GD3.	Gangliosides	154-165	GRDX	Homo sapiens	131-134
2674112-1	1989	Alteration of ganglioside composition in mouse BALB/3T3 cells transformed either by DNA transfection with viral K-, H-, or cellular H-ras oncogene, or by infection with the K-ras oncogene-carrying murine sarcoma virus (Ki-KSV) was studied using a highly sensitive thin-layer chromatography/enzyme immunostaining method.	Gangliosides	14-25	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	173-178
2744127-3	1989	The ganglioside regimen reduced the ODC response in the injected hippocampus but increased it on the side contralateral to the colchicine injection.	Gangliosides	4-15	ornithine decarboxylase 1	Homo sapiens	36-39
2744127-7	1989	Ganglioside GM1 altered the ODC response without minimizing the histopathological changes induced by the cytotoxins.	Gangliosides	0-11	ornithine decarboxylase 1	Homo sapiens	28-31
2670153-2	1989	The binding of 125I-labeled LTp to neuraminidase-treated human type A erythrocytes was most effectively inhibited by ganglioside GM1.	Gangliosides	117-128	neuraminidase 1	Homo sapiens	35-48
2470785-6	1989	These studies indicate that in addition to gangliosides the M-proteins might bind to Gal(beta 1-3)GalNAc bearing glycoproteins in vivo and that carbohydrate epitopes on immunoglobulins might have a role in the development and regulation of autoantibodies which cross-react with neural antigens and may cause neurological disease.	Gangliosides	43-55	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	89-97
2744885-0	1989	Ganglioside GD3 shedding by human malignant melanoma cells.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
2744885-2	1989	Therefore in vitro studies were performed to examine whether ganglioside GD3, which is highly expressed on the cell surface of cultured human melanoma cells, is being shed into the culture medium.	Gangliosides	61-72	GRDX	Homo sapiens	73-76
2744885-4	1989	Ganglioside GD3 was also evidenced by immunostaining with anti-GD3 MAb and by ELISA.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
2744885-4	1989	Ganglioside GD3 was also evidenced by immunostaining with anti-GD3 MAb and by ELISA.	Gangliosides	0-11	GRDX	Homo sapiens	63-66
2744885-5	1989	The concentration of GD3 in the supernatant of human melanoma cells depended on the ganglioside pattern of the cell line.	Gangliosides	84-95	GRDX	Homo sapiens	21-24
2744885-7	1989	Ganglioside GD3 was detectable in sera, but no major quantitative differences were observed in sera of patients with GD3-positive tumors and normal controls.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
2744885-8	1989	This points to a local accumulation of ganglioside GD3 at the tumor site.	Gangliosides	39-50	GRDX	Homo sapiens	51-54
2470823-1	1989	Rat macrophages express a binding structure for sialic acid-containing glycoconjugates (sialic acid-binding receptor, SAR) which can be detected by a rosette assay utilizing SRBC coated with bovine brain gangliosides (E-G).	Gangliosides	204-216	sarcosinemia autosomal recessive	Mus musculus	118-121
2498125-2	1989	Competition experiments using gangliosides GA2, GM2 and GD2 as substrates, and as mutual inhibitors for ganglioside galactosyltransferase activity in preparations of Golgi vesicles derived from rat liver, suggested that galactosyl transfer to these three compounds, leading to gangliosides GA1, GM1a and GD1b respectively, is catalyzed by one enzyme.	Gangliosides	30-42	Beta-1,3-galactosyltransferase 4	Rattus norvegicus	104-137
2714890-0	1989	Ganglioside GM2 expression on human melanoma cells correlates with sensitivity to lymphokine-activated killer cells.	Gangliosides	0-11	interleukin 2	Homo sapiens	82-92
2754761-6	1989	In bovine oligodendrocytes GD3 is the major ganglioside.	Gangliosides	44-55	GRDX	Homo sapiens	27-30
2653466-1	1989	3F8 is a murine monoclonal IgG3 antibody specific for the tumor-associated antigen ganglioside GD2.	Gangliosides	83-94	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	27-31
2498125-2	1989	Competition experiments using gangliosides GA2, GM2 and GD2 as substrates, and as mutual inhibitors for ganglioside galactosyltransferase activity in preparations of Golgi vesicles derived from rat liver, suggested that galactosyl transfer to these three compounds, leading to gangliosides GA1, GM1a and GD1b respectively, is catalyzed by one enzyme.	Gangliosides	277-289	Beta-1,3-galactosyltransferase 4	Rattus norvegicus	104-137
2705899-2	1989	Analysis of variance revealed that mean concentrations of all gangliosides analyzed were significantly lower in DAT than in control brains.	Gangliosides	62-74	solute carrier family 6 member 3	Homo sapiens	112-115
2649154-7	1989	Although these findings show that there may be fundamental differences between interactions with ganglioside GM1 in hemagglutination compared to interactions with ganglioside GM1 in binding, the predominant binding substance for LTp on neuraminidase-treated human type A erythrocytes is suggested to be ganglioside GM1.	Gangliosides	163-174	neuraminidase 1	Homo sapiens	236-249
2725993-8	1989	These results suggest that the increase of ganglioside GD3 in long-term-cultured astrocytes may be related to the appearance of multistellate cells showing strong reactivity against GFAP and vimentin during development over a specified period in culture.	Gangliosides	43-54	glial fibrillary acidic protein	Rattus norvegicus	182-186
2764976-2	1989	Whereas very few changes over the normal level were noticed in benign cases, 78% of patients with head and neck carcinomas had a significant elevation of serum gangliosides, mostly accounted for by GM3 and GD3.	Gangliosides	160-172	GRDX	Homo sapiens	206-209
2784717-0	1989	Augmentation of lymphocyte responses by monoclonal antibodies to the gangliosides GD3 and GD2: the role of protein kinase C, cyclic nucleotides, and intracellular calcium.	Gangliosides	69-81	GRDX	Homo sapiens	82-85
2784717-1	1989	Previous studies have shown that MAb"s against the gangliosides GD3 and GD2 may augment T cell responses to a variety of stimuli.	Gangliosides	51-63	GRDX	Homo sapiens	64-67
2725993-8	1989	These results suggest that the increase of ganglioside GD3 in long-term-cultured astrocytes may be related to the appearance of multistellate cells showing strong reactivity against GFAP and vimentin during development over a specified period in culture.	Gangliosides	43-54	vimentin	Rattus norvegicus	191-199
2765299-4	1989	The gangliosides that react to neuraminidase are SPG, GD1a and GD1b in U 251 cells and are GM1a and little GM3 in C 6 cells.	Gangliosides	4-16	neuraminidase 1	Homo sapiens	31-44
2765299-2	1989	As a result, the major gangliosides were simple gangliosides such as GM3 (U 251: 7.7%, C6: 84.3%), GM2 (U 251: 32.6%) and SPG (U 251: 30.0%) on glioma cells whereas the major neutral glycosphingolipids were CDH, CTH and globoside.	Gangliosides	23-35	V-set and immunoglobulin domain containing 2	Homo sapiens	212-215
2645049-1	1989	With the aid of a highly specific murine monoclonal antibody, F12, an immunofluorescence method was elaborated that allowed sensitive and specific detection of the ganglioside antigen fucosyl-GM1 (IV2FucII3NeuAcGgOse4Cer) in different types of human lung cancer and normal tissues.	Gangliosides	164-175	coagulation factor XII	Homo sapiens	62-65
2535260-1	1989	We have shown that a syngenic monoclonal antibody, M2590, established after immunization of C57BL/6 mice with B16 melanoma cells, recognized GM3 (NeuAc) ganglioside.	Gangliosides	153-164	granulocyte macrophage antigen 3	Mus musculus	141-144
2521835-0	1989	A neuroectoderm-associated ganglioside participates in fibronectin receptor-mediated adhesion of germinal cells to fibronectin.	Gangliosides	27-38	fibronectin 1	Rattus norvegicus	55-66
2521835-0	1989	A neuroectoderm-associated ganglioside participates in fibronectin receptor-mediated adhesion of germinal cells to fibronectin.	Gangliosides	27-38	fibronectin 1	Rattus norvegicus	115-126
2521835-1	1989	Previous studies with a rat neural cell line have shown that the D1.1 ganglioside, an O-acetylated derivative of GD3, is involved in cellular adhesion to fibronectin.	Gangliosides	70-81	fibronectin 1	Rattus norvegicus	154-165
2521835-7	1989	Adhesion is also partially inhibited by antibody against fibronectin receptor and is slowed by anti-D1.1 antibody, implicating both the receptor and the ganglioside in the adhesion process.	Gangliosides	153-164	fibronectin 1	Rattus norvegicus	57-68
2519201-3	1989	One is the ganglioside-dependent modulation of autophosphorylation of EGF or PDGF receptors, by which altered the cell growth.	Gangliosides	11-22	epidermal growth factor	Homo sapiens	70-73
2519203-2	1989	Interestingly, gangliosides induced selective modulation of CD4, which is not only the subset marker of T-lymphocytes but also the receptor for human immunodeficiency virus.	Gangliosides	15-27	CD4 molecule	Homo sapiens	60-63
2519204-5	1989	ras and src, brought about SPG gangliosides but no GD3 expression was recognized.	Gangliosides	31-43	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	8-11
2640560-4	1989	The mast cell degranulation caused by [Thi5,8,D-Phe7]bradykinin and bradykinin was inhibited by gangliosides but not by heparin.	Gangliosides	96-108	kininogen 1	Homo sapiens	53-63
2494280-4	1989	In contrast, interferon gamma (IFN-gamma)-primed macrophages showed a dramatic shift in intensity of one ganglioside when treated with LPS in vitro; an additional macrophage ganglioside appeared when IFN-gamma-primed, LPS-treated macrophages were coincubated with lymphocytes.	Gangliosides	105-116	interferon gamma	Mus musculus	13-40
2494280-4	1989	In contrast, interferon gamma (IFN-gamma)-primed macrophages showed a dramatic shift in intensity of one ganglioside when treated with LPS in vitro; an additional macrophage ganglioside appeared when IFN-gamma-primed, LPS-treated macrophages were coincubated with lymphocytes.	Gangliosides	105-116	interferon gamma	Mus musculus	31-40
2494280-4	1989	In contrast, interferon gamma (IFN-gamma)-primed macrophages showed a dramatic shift in intensity of one ganglioside when treated with LPS in vitro; an additional macrophage ganglioside appeared when IFN-gamma-primed, LPS-treated macrophages were coincubated with lymphocytes.	Gangliosides	174-185	interferon gamma	Mus musculus	13-40
2494280-4	1989	In contrast, interferon gamma (IFN-gamma)-primed macrophages showed a dramatic shift in intensity of one ganglioside when treated with LPS in vitro; an additional macrophage ganglioside appeared when IFN-gamma-primed, LPS-treated macrophages were coincubated with lymphocytes.	Gangliosides	174-185	interferon gamma	Mus musculus	31-40
2494280-8	1989	IFN-gamma appears to be one important mediator; however, complex interactions involving other cytokines or migration of independent populations of mononuclear cells may be required for the full manifestation of LPS-induced ganglioside expression in macrophages.	Gangliosides	223-234	interferon gamma	Mus musculus	0-9
2928318-0	1989	Gangliosides potentiate in vivo and in vitro effects of nerve growth factor on central cholinergic neurons.	Gangliosides	0-12	nerve growth factor	Rattus norvegicus	56-75
2640560-4	1989	The mast cell degranulation caused by [Thi5,8,D-Phe7]bradykinin and bradykinin was inhibited by gangliosides but not by heparin.	Gangliosides	96-108	kininogen 1	Homo sapiens	68-78
2783860-0	1989	Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by complex gangliosides.	Gangliosides	108-120	fibronectin 1	Homo sapiens	35-46
2493244-0	1989	Characteristic mode of action of gangliosides in selective modulation of CD4 on human T lymphocytes.	Gangliosides	33-45	CD4 molecule	Homo sapiens	73-76
2493244-1	1989	We have explored the possible mechanisms for selective modulation by gangliosides of CD4 on human T lymphocytes and subsequent re-expression of CD4.	Gangliosides	69-81	CD4 molecule	Homo sapiens	85-88
2493244-1	1989	We have explored the possible mechanisms for selective modulation by gangliosides of CD4 on human T lymphocytes and subsequent re-expression of CD4.	Gangliosides	69-81	CD4 molecule	Homo sapiens	144-147
2493244-2	1989	Indirect immunofluorescence staining with anti-CD4 antibodies revealed newly internalized CD4 in ganglioside-treated cells after membrane permeabilization with 0.1% saponin.	Gangliosides	97-108	CD4 molecule	Homo sapiens	47-50
2493244-2	1989	Indirect immunofluorescence staining with anti-CD4 antibodies revealed newly internalized CD4 in ganglioside-treated cells after membrane permeabilization with 0.1% saponin.	Gangliosides	97-108	CD4 molecule	Homo sapiens	90-93
2783860-0	1989	Inhibition of platelet adhesion to fibronectin, fibrinogen, and von Willebrand factor substrates by complex gangliosides.	Gangliosides	108-120	von Willebrand factor	Homo sapiens	64-85
2783860-2	1989	Complex gangliosides were observed to inhibit the adhesion of thrombin-activated platelets to substrates of fibronectin, von Willebrand factor, and fibrinogen.	Gangliosides	8-20	coagulation factor II, thrombin	Homo sapiens	62-70
2914959-2	1989	Ganglioside GD3 was converted at room temperature to two stable lactones, denoted as GD3 lactones I and II.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
2914959-2	1989	Ganglioside GD3 was converted at room temperature to two stable lactones, denoted as GD3 lactones I and II.	Gangliosides	0-11	GRDX	Homo sapiens	85-88
2536394-0	1989	Motor dominant neuropathy and IgM paraproteinemia: the IgM M-protein binds to specific gangliosides.	Gangliosides	87-99	myomesin 2	Homo sapiens	59-68
2783860-2	1989	Complex gangliosides were observed to inhibit the adhesion of thrombin-activated platelets to substrates of fibronectin, von Willebrand factor, and fibrinogen.	Gangliosides	8-20	fibronectin 1	Homo sapiens	108-119
2783860-2	1989	Complex gangliosides were observed to inhibit the adhesion of thrombin-activated platelets to substrates of fibronectin, von Willebrand factor, and fibrinogen.	Gangliosides	8-20	von Willebrand factor	Homo sapiens	121-142
2783860-2	1989	Complex gangliosides were observed to inhibit the adhesion of thrombin-activated platelets to substrates of fibronectin, von Willebrand factor, and fibrinogen.	Gangliosides	8-20	fibrinogen beta chain	Homo sapiens	148-158
2715723-7	1989	The activity of CMP-N-acetylneuraminic acid:lactosylceramide sialyltransferase (ST1), a key enzyme for membrane gangliosides synthesis, in HL-60 cells was also influenced by the exposure to TPA, GM3, DMSO, GM1, or sulfatides.	Gangliosides	112-124	syndecan binding protein	Homo sapiens	80-83
2536394-2	1989	The serum IgM M-protein bound preferentially to ganglioside GM1 with slight cross-reactivity to both GM2 and GD1b.	Gangliosides	48-59	myomesin 2	Homo sapiens	14-23
2910834-3	1989	The major gangliosides were GM3, GM2, GM1 and GD1a.	Gangliosides	10-22	granulocyte macrophage antigen 3	Mus musculus	28-31
2784553-4	1989	In addition, in the presence of gangliosides (GM1, GD1a, GD1b GT1b), the numbers of regrown RGC axons (Thy 1-immunostained) increased dramatically as compared to controls.	Gangliosides	32-44	Thy-1 cell surface antigen	Rattus norvegicus	103-108
2910834-3	1989	The major gangliosides were GM3, GM2, GM1 and GD1a.	Gangliosides	10-22	cytochrome b5 domain containing 2	Mus musculus	33-36
2910834-3	1989	The major gangliosides were GM3, GM2, GM1 and GD1a.	Gangliosides	10-22	coenzyme Q10A	Mus musculus	38-41
2731185-11	1989	By comparison with its binding to the control ganglioside panel, this serum demonstrated strong specificity for GD3 (titer = 640) while having only marginal reactivity with GM3 (titer = 40).	Gangliosides	46-57	GRDX	Homo sapiens	112-115
2524255-0	1989	Potentiation of interleukin-2 production and its binding by monoclonal antibodies to the gangliosides GD3 and GD2.	Gangliosides	89-101	interleukin 2	Homo sapiens	16-29
2524255-0	1989	Potentiation of interleukin-2 production and its binding by monoclonal antibodies to the gangliosides GD3 and GD2.	Gangliosides	89-101	GRDX	Homo sapiens	102-105
2791750-0	1989	Bioactive ganglioside-mediated carbohydrate recognition in coupling with ecto-protein phosphorylation.	Gangliosides	10-21	tripartite motif containing 33	Homo sapiens	73-77
2524255-1	1989	Previous studies have shown that monoclonal antibodies (mAbs) against certain gangliosides, which induced remissions in patients with melanoma, also potentiated the response of lymphocytes to a variety of stimuli, including lectins, interleukin-2 (IL-2) and antigens.	Gangliosides	78-90	interleukin 2	Homo sapiens	233-246
2524255-1	1989	Previous studies have shown that monoclonal antibodies (mAbs) against certain gangliosides, which induced remissions in patients with melanoma, also potentiated the response of lymphocytes to a variety of stimuli, including lectins, interleukin-2 (IL-2) and antigens.	Gangliosides	78-90	interleukin 2	Homo sapiens	248-252
2908845-9	1989	Among NeuGc-type gangliosides, this antibody reacts with (NeuAc-NeuGc-)-GD3 and -disialylparagloboside, but did not react with gangliosides containing only NeuGc.	Gangliosides	17-29	GRDX	Homo sapiens	72-75
2908845-11	1989	Mouse anti-GD3 mAbR24, in contrast, showed strong reactivity only with GD3 and -disialylparagloboside among NeuAc-type gangliosides, but showed a similar pattern to AbHJM1 in its reactivity with NeuGc-containing gangliosides.	Gangliosides	119-131	GRDX	Homo sapiens	11-14
2908845-11	1989	Mouse anti-GD3 mAbR24, in contrast, showed strong reactivity only with GD3 and -disialylparagloboside among NeuAc-type gangliosides, but showed a similar pattern to AbHJM1 in its reactivity with NeuGc-containing gangliosides.	Gangliosides	212-224	GRDX	Homo sapiens	11-14
2530410-0	1989	Specific ganglioside binding to receptor sites on T lymphocytes that couple to ganglioside-induced decrease of CD4 expression.	Gangliosides	9-20	Cd4 molecule	Rattus norvegicus	111-114
2535812-2	1989	PYY and neuropeptide Y (NPY) bound with high affinity to crude membrane preparations from the hippocampus, but their C-terminal fragments bound with 30- to 450-fold lower affinity Guanine nucleotides, especially the nonhydrolyzable GTP analog GTP gammas inhibited the binding of [125I]PYY, but other transmitters, hormones, and central nervous system-acting drugs did not, except for gangliosides at high concentrations.	Gangliosides	384-396	peptide YY	Homo sapiens	0-3
2535812-2	1989	PYY and neuropeptide Y (NPY) bound with high affinity to crude membrane preparations from the hippocampus, but their C-terminal fragments bound with 30- to 450-fold lower affinity Guanine nucleotides, especially the nonhydrolyzable GTP analog GTP gammas inhibited the binding of [125I]PYY, but other transmitters, hormones, and central nervous system-acting drugs did not, except for gangliosides at high concentrations.	Gangliosides	384-396	neuropeptide Y	Homo sapiens	8-22
2530410-0	1989	Specific ganglioside binding to receptor sites on T lymphocytes that couple to ganglioside-induced decrease of CD4 expression.	Gangliosides	79-90	Cd4 molecule	Rattus norvegicus	111-114
2530410-1	1989	The binding of different gangliosides to rat T-helper lymphocytes was characterized under conditions that decrease CD4 expression on different mammalian T-helper lymphocytes.	Gangliosides	25-37	Cd4 molecule	Rattus norvegicus	115-118
2530410-4	1989	A comparison between the results of these binding studies and ganglioside-induced decrease of CD4 expression demonstrated that every aspect of [3H]-GM1 binding concurs with ganglioside modulation of CD4 expression.	Gangliosides	62-73	Cd4 molecule	Rattus norvegicus	94-97
2530410-4	1989	A comparison between the results of these binding studies and ganglioside-induced decrease of CD4 expression demonstrated that every aspect of [3H]-GM1 binding concurs with ganglioside modulation of CD4 expression.	Gangliosides	62-73	Cd4 molecule	Rattus norvegicus	199-202
2530410-4	1989	A comparison between the results of these binding studies and ganglioside-induced decrease of CD4 expression demonstrated that every aspect of [3H]-GM1 binding concurs with ganglioside modulation of CD4 expression.	Gangliosides	173-184	Cd4 molecule	Rattus norvegicus	94-97
2530410-4	1989	A comparison between the results of these binding studies and ganglioside-induced decrease of CD4 expression demonstrated that every aspect of [3H]-GM1 binding concurs with ganglioside modulation of CD4 expression.	Gangliosides	173-184	Cd4 molecule	Rattus norvegicus	199-202
2530410-5	1989	It is concluded that the specific decrease of CD4 expression induced by pretreatment with gangliosides involves the initial process of ganglioside binding to specific sites on CD4+ T-helper lymphocytes.	Gangliosides	90-102	Cd4 molecule	Rattus norvegicus	46-49
2530410-5	1989	It is concluded that the specific decrease of CD4 expression induced by pretreatment with gangliosides involves the initial process of ganglioside binding to specific sites on CD4+ T-helper lymphocytes.	Gangliosides	90-102	Cd4 molecule	Rattus norvegicus	176-179
2530410-5	1989	It is concluded that the specific decrease of CD4 expression induced by pretreatment with gangliosides involves the initial process of ganglioside binding to specific sites on CD4+ T-helper lymphocytes.	Gangliosides	90-101	Cd4 molecule	Rattus norvegicus	46-49
2530410-5	1989	It is concluded that the specific decrease of CD4 expression induced by pretreatment with gangliosides involves the initial process of ganglioside binding to specific sites on CD4+ T-helper lymphocytes.	Gangliosides	90-101	Cd4 molecule	Rattus norvegicus	176-179
3266614-1	1988	Studies were carried out to determine whether inhibition of gangliosides on lymphoproliferation was related to interleukin (IL)-1.	Gangliosides	60-72	interleukin 1 complex	Mus musculus	111-129
2853012-4	1988	Two dimensional thin-layer chromatography of the total ganglioside preparations of liver tissues from both liver cirrhosis and hepatocellular carcinoma showed proliferation of GM2, GD3, GD1 and at least two unidentified components, named provisionally spots Nos.	Gangliosides	55-66	GRDX	Homo sapiens	181-184
3264007-7	1988	Consistent with previous observations on macrophage gangliosides, the ratio of N-acetylneuraminic acid-containing ganglioside to N-glycolylneuraminic acid-containing ganglioside was higher in both thymocytes and T-cells from the LPS-responder strain.	Gangliosides	114-125	toll-like receptor 4	Mus musculus	229-232
3149523-14	1988	The major gangliosides of the non-epithelial tissue were identified as GM3, GM1, GD3, GD1b, GT1b and GQ1b.	Gangliosides	10-22	GRDX	Homo sapiens	81-84
3167861-2	1988	The monoclonal antibodies MK2-34 and MK1-16 (both IgM), which specifically detect N-glycolyl GM2 and N-acetyl GM2, respectively, were generated by immunizing mice with liposomes containing monophosphoryl lipid A, trehalose dimycolate, and the antigenic ganglioside.	Gangliosides	253-264	kallikrein 1-related peptidase b1	Mus musculus	37-43
3061458-10	1988	Insulin exhibits a weak but remarkable nonspecific binding to bilayers of pure DMPC and DMPC containing 20% positively charged lipid and a strong binding to DMPC containing negatively charged lipids such as phosphatidylserine or ganglioside (GT1b).	Gangliosides	229-240	insulin	Homo sapiens	0-7
3139288-5	1988	In addition both pro-1 and pro-2 transfectants showed inhibition of phorbol ester induced transformation by antipromoters ganglioside GT1b, ethylene glycol bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid, and forskolin.	Gangliosides	122-133	proline dehydrogenase	Mus musculus	17-22
3189815-7	1988	For the latter, an additional step involving reaction with fucosidase increased the yield of GM1 due to the presence of fucosylated gangliosides.	Gangliosides	132-144	coenzyme Q10A	Mus musculus	93-96
2458363-1	1988	The identification of specific cell surface glycoprotein receptors for Arg-Gly-Asp-containing extracellular matrix proteins such as fibronectin has focused attention on the role of gangliosides in this process.	Gangliosides	181-193	fibronectin 1	Homo sapiens	132-143
2457654-7	1988	The data suggest that the epitope for both of these IgMs is in the GalNAc(beta 1-4)(NeuAc alpha 2-3)Gal(beta 1-4)Glc region of the gangliosides that is common to both GM2 and GM1.	Gangliosides	131-143	tubulin beta 3 class III	Homo sapiens	74-82
2457654-7	1988	The data suggest that the epitope for both of these IgMs is in the GalNAc(beta 1-4)(NeuAc alpha 2-3)Gal(beta 1-4)Glc region of the gangliosides that is common to both GM2 and GM1.	Gangliosides	131-143	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	104-112
2457603-2	1988	In previous studies, both M-proteins bound to gangliosides GM1 and GD1b which share Gal(beta 1-3)GalNAc as their terminal structure, and to lacto-N-tetraose-BSA which has the structure Gal(beta 1-3)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-BSA.	Gangliosides	46-58	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	88-96
2457603-2	1988	In previous studies, both M-proteins bound to gangliosides GM1 and GD1b which share Gal(beta 1-3)GalNAc as their terminal structure, and to lacto-N-tetraose-BSA which has the structure Gal(beta 1-3)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-BSA.	Gangliosides	46-58	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	88-94
3263817-0	1988	Detection of gangliosides of the GM1b type on high-performance thin-layer chromatography plates by immunostaining after neuraminidase treatment.	Gangliosides	13-25	neuraminidase 1	Homo sapiens	120-133
2839353-1	1988	The B subunit of cholera toxin, which binds specifically to ganglioside GM1, stimulates DNA synthesis in quiescent Swiss 3T3 fibroblasts grown in chemically defined medium.	Gangliosides	60-71	coenzyme Q10A	Mus musculus	72-75
2456347-10	1988	These data indicate that N-linked glycosylation or ganglioside synthesis is crucial for the expression of the Hh-1 locus-controlled target structures, but not for the H-2 class I molecules.	Gangliosides	51-62	hemopoietic histocompatibility	Mus musculus	110-114
3392043-8	1988	With enzyme preparations from the other strains lactosylceramide was the single major degradation product from complex glycosphingolipids with less than 30% further degradation to glucosylceramide within 48 h. We conclude that glycosidases from mucin-degrading strains of human enteric bacteria degrade oligosaccharide chains of lactoseries fucolipids and gangliosides of intestinal origin primarily to lactosylceramide.	Gangliosides	356-368	LOC100508689	Homo sapiens	245-250
3292056-0	1988	Antibodies to cell surface ganglioside GD3 perturb inductive epithelial-mesenchymal interactions.	Gangliosides	27-38	GRDX	Homo sapiens	39-42
3164721-1	1988	A mouse monoclonal antibody, VIM-2, specific for human blood cells of myelomonocytic lineage, was found to bind to a series of minor gangliosides isolated from the cells of patients with chronic myelogenous leukemia (Uemura, K., Macher, B.A., DeGregorio, M., Scudder, P., Buehler, J., Knapp, W., and Feizi, T. (1985) Biochim.	Gangliosides	133-145	vimentin 2, pseudogene	Homo sapiens	29-34
3164721-4	1988	TLC immunostaining studies with the VIM-2 antibody of gangliosides from normal human neutrophils, acute myeloid leukemia, and chronic myelogenous leukemia cells showed that the total amount and the ratio of the VIM-2 gangliosides varies among these different myeloid cells and appears to be related to the level of cellular differentiation.	Gangliosides	54-66	vimentin 2, pseudogene	Homo sapiens	36-41
3164721-4	1988	TLC immunostaining studies with the VIM-2 antibody of gangliosides from normal human neutrophils, acute myeloid leukemia, and chronic myelogenous leukemia cells showed that the total amount and the ratio of the VIM-2 gangliosides varies among these different myeloid cells and appears to be related to the level of cellular differentiation.	Gangliosides	54-66	vimentin 2, pseudogene	Homo sapiens	211-216
3191505-8	1988	Chemical-shift correlations proved to be useful in elucidating the structure of a unique ganglioside bearing an internal beta-D-Galp-(1----4)-[alpha-L-Fucp-(1----3)]-beta-D-GlcpNAc-(1---- 3) residue ("X-trisaccharide") with an alpha-NeuAc-(2----6)-substituted terminal group.	Gangliosides	89-100	galanin like peptide	Homo sapiens	128-132
2968913-0	1988	Involvement of gangliosides and glycoprotein fibronectin receptors in cellular adhesion to fibronectin.	Gangliosides	15-27	fibronectin 1	Homo sapiens	91-102
3228511-0	1988	GBP: a membrane protein of presynaptic vesicles which specifically binds gangliosides.	Gangliosides	73-85	transmembrane protein 132A	Homo sapiens	0-3
3133241-6	1988	The structures of the gangliosides, each identified by means of permethylation anaylsis and enzyme treatment after isolation with antibody monitoring, were shown to be IV6NeuAcnLc4Cer for the former and IV3NeuAcLc4Cer for the latter, indicating that the lacto-series type 2 (nLc4Cer) and 1 (Lc4Cer) chains are sialylated at different linkages, alpha 2-6 and alpha 2-3, respectively.	Gangliosides	22-34	immunoglobulin binding protein 1	Homo sapiens	344-353
3220834-1	1988	Ganglioside GM1(NeuAc), labeled at the C-3 position of sphingosine with tritium, was injected into C3H/He, C57BL/10, B10.AQR mice intraperitoneally.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-22
3169039-6	1988	The formation of both neurite classes on either pFN or CTB was completely inhibited by low concentrations of an RGDS (Arg-Gly-Asp-Ser) peptide in the medium of cultures, indicating the significance of pFN"s binding to cell surface integrin or ganglioside GM1"s possible interaction with integrin for mediating the differentiative process.	Gangliosides	243-254	ral guanine nucleotide dissociation stimulator	Homo sapiens	112-116
3408725-4	1988	Golgi SAT was diversified in producing all the various molecular species of labeled gangliosides [2.64 pmol of NeuAc transferred (mg of protein)-1 h-1].	Gangliosides	84-96	spermidine/spermine N1-acetyltransferase family member 2	Rattus norvegicus	6-9
3253621-2	1988	The monoclonal IgMs in several of the patients bind to the carbohydrate epitope Gal (beta 1-3) GalNAc, which is shared by gangliosides GM1 and GD1b and glycoproteins in the nervous system and crossreacted with Gal (beta 1-3) GlcNAc.	Gangliosides	122-134	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	85-93
3408725-8	1988	This SAT could function as an ectoenzyme in concert with ecto-sialidase to modulate the GD3 and other ganglioside population in situ at the SPM of the central nervous system.	Gangliosides	102-113	spermidine/spermine N1-acetyltransferase family member 2	Rattus norvegicus	5-8
2834372-0	1988	A novel ganglioside, de-N-acetyl-GM3 (II3NeuNH2LacCer), acting as a strong promoter for epidermal growth factor receptor kinase and as a stimulator for cell growth.	Gangliosides	8-19	granulocyte macrophage antigen 3	Mus musculus	33-36
3378149-9	1988	These results suggest an in vivo interaction between exogenous GM1 and NGF and are consistent with the view that neuronal cell repair related to in vivo administration of this ganglioside may rely on its capability to modulate the activity of endogenously occurring neuronotrophic factors.	Gangliosides	176-187	nerve growth factor	Rattus norvegicus	71-74
2834372-1	1988	A novel ganglioside, de-N-acetyl-GM3 (neuraminyllactosylceramide, II3NeuNH2LacCer), was found in the monosialoganglioside fraction of A431 cells and B16 melanoma cells by high-performance liquid chromatography, thin-layer chromatography, and immunoblotting with its specific monoclonal antibody DH5.	Gangliosides	8-19	granulocyte macrophage antigen 3	Mus musculus	33-36
2834372-2	1988	This novel type of membrane ganglioside strongly enhanced the kinase activity associated with the epidermal growth factor (EGF) receptor, and it showed 32, 35, and 12% growth stimulation as compared with control cultures of A431, Swiss 3T3, and B16 melanoma cells, respectively.	Gangliosides	28-39	epidermal growth factor receptor	Mus musculus	98-136
2966069-0	1988	Ganglioside-dependent adhesion events of human neuroblastoma cells regulated by the RGDS-dependent fibronectin receptor and proteoglycans.	Gangliosides	0-11	ral guanine nucleotide dissociation stimulator	Homo sapiens	84-88
3389760-1	1988	We demonstrated that an IgM M-protein from a patient with motor neuron syndrome had antibody activity against gangliosides GM1, GD1b, and asialo GM1.	Gangliosides	110-122	myomesin 2	Homo sapiens	28-37
3128327-0	1988	beta-Galactosidase-induced destabilization of liposome composed of phosphatidylethanolamine and ganglioside GM1.	Gangliosides	96-107	galactosidase beta 1	Homo sapiens	0-18
2965546-6	1988	These results indicate a possible role for UDP-amino sugars in the depression of ganglioside biosynthesis observed in vivo after GalN administration.	Gangliosides	81-92	galanin and GMAP prepropeptide	Rattus norvegicus	129-133
2966069-0	1988	Ganglioside-dependent adhesion events of human neuroblastoma cells regulated by the RGDS-dependent fibronectin receptor and proteoglycans.	Gangliosides	0-11	fibronectin 1	Homo sapiens	99-110
2966069-1	1988	Human neuroblastoma cells (Platt and La-N1) adhere and extend neurites on a ganglioside GM1-binding substratum provided by cholera toxin B (CTB).	Gangliosides	76-87	chitobiase	Homo sapiens	140-143
2966069-5	1988	The involvement of two pFN receptor molecules in ganglioside GM1-mediated responses on CTB have now been tested.	Gangliosides	49-60	chitobiase	Homo sapiens	87-90
2449247-5	1988	This monoclonal antibody (Y-2-HD-1) bound to native mouse erythrocytes, in which GM2(NeuGc) is a major ganglioside.	Gangliosides	103-114	cytochrome b5 domain containing 2	Mus musculus	81-91
3126266-0	1988	Specific binding of glycosylated beta-galactosidase to rat clonal pheochromocytoma PC12h cells: effects of nerve growth factor and gangliosides.	Gangliosides	131-143	galactosidase, beta 1	Rattus norvegicus	33-51
3126266-5	1988	When the cells were cultured in the presence of nerve growth factor (NGF), GM1, GM2, and a ganglioside mixture, marked morphological differentiation was observed in the presence of NGF, and the specificity of the binding was also affected.	Gangliosides	91-102	nerve growth factor	Rattus norvegicus	48-67
3126266-5	1988	When the cells were cultured in the presence of nerve growth factor (NGF), GM1, GM2, and a ganglioside mixture, marked morphological differentiation was observed in the presence of NGF, and the specificity of the binding was also affected.	Gangliosides	91-102	nerve growth factor	Rattus norvegicus	181-184
3346718-5	1988	GM1 effects are not limited to dopaminergic neurons, and depend on the stable association of the ganglioside molecule with the cells.	Gangliosides	97-108	coenzyme Q10A	Mus musculus	0-3
3163528-5	1988	These gangliosides were isolated and identified as GM3, GM2, GM1a, GD1a, GM1b, and a unique disialoganglioside, GD1 alpha, having the following structure: (formula; see text) Based on these comparative studies, the relationship between the glycolipid composition and the differentiation potential of leukemia cells is discussed.	Gangliosides	6-18	granulocyte macrophage antigen 3	Mus musculus	51-54
2448252-7	1988	The ganglioside content of EL4 was low in comparison with that of M14 (a human melanoma cell line).	Gangliosides	4-15	epilepsy 4	Mus musculus	27-30
3342263-0	1988	Stimulation of platelet adhesion and activation by ganglioside GD3 adsorbed to plastic.	Gangliosides	51-62	GRDX	Homo sapiens	63-66
3342263-4	1988	The adhesion of gel-filtered platelets to ganglioside GD3 was 3-4 times higher than to other immobilized gangliosides and to albumin-treated plastic.	Gangliosides	42-53	GRDX	Homo sapiens	54-57
3339003-0	1988	Human melanoma antigen O-acetylated ganglioside GD3 is recognized by Cancer antennarius lectin.	Gangliosides	36-47	GRDX	Homo sapiens	48-51
3339003-11	1988	Subsequently, the purified alkali-labile M25 ganglioside was base-treated and applied to TLC, and we found that it was converted to a slower migrating species identical to the disialolactosylceramide (GD3).	Gangliosides	45-56	GRDX	Homo sapiens	201-204
3349045-8	1988	The concentration of ganglioside sialic acid was approximately 0.34 and 0.18 microgram/mg of protein for cells grown in the presence and absence of NGF, respectively.	Gangliosides	21-32	nerve growth factor	Rattus norvegicus	148-151
3123073-0	1988	Gangliosides from human melanoma immunomodulate response of T cells to interleukin-2.	Gangliosides	0-12	interleukin 2	Homo sapiens	71-84
3123073-1	1988	The gangliosides expressed by normal melanocytes are predominantly GM3 (greater than 90%) and GD3 (less than 5%).	Gangliosides	4-16	GRDX	Homo sapiens	94-97
3123073-5	1988	Gangliosides were added exogenously to lymphocytes grown in the presence of IL-2.	Gangliosides	0-12	interleukin 2	Homo sapiens	76-80
3123073-6	1988	Preferential interactions of specific melanoma gangliosides on IL-2 stimulation were found.	Gangliosides	47-59	interleukin 2	Homo sapiens	63-67
3123073-9	1988	Since different gangliosides can up-regulate and down-regulate lymphocyte responses to IL-2, the ganglioside phenotype of melanoma cells may play a major role in determining whether an individual tumor causes immune stimulation or suppression.	Gangliosides	16-28	interleukin 2	Homo sapiens	87-91
3338538-5	1988	The effect of gangliosides on the axonal diameter was opposite that of alpha-MSH: treatment with gangliosides stimulated the formation of axons with a smaller diameter.	Gangliosides	97-109	proopiomelanocortin	Rattus norvegicus	71-80
3123073-9	1988	Since different gangliosides can up-regulate and down-regulate lymphocyte responses to IL-2, the ganglioside phenotype of melanoma cells may play a major role in determining whether an individual tumor causes immune stimulation or suppression.	Gangliosides	16-27	interleukin 2	Homo sapiens	87-91
3349045-9	1988	Although there was an increase in ganglioside concentration in NGF-treated cells, NGF did not produce any differential effects on the relative proportions of the individual gangliosides.	Gangliosides	34-45	nerve growth factor	Rattus norvegicus	63-66
2449128-0	1988	Monoclonal antibody R24 distinguishes between different N-acetyl- and N-glycolylneuraminic acid derivatives of ganglioside GD3.	Gangliosides	111-122	GRDX	Homo sapiens	123-126
3051920-4	1988	Gangliosides containing C18 and C20 sphinganine were prepared by catalytic hydrogenation of the corresponding unsaturated gangliosides.	Gangliosides	0-12	Bardet-Biedl syndrome 9	Homo sapiens	24-27
3207263-0	1988	Neuropathy and monoclonal IgM M-protein with antibody activity against gangliosides.	Gangliosides	71-83	myomesin 2	Homo sapiens	30-39
2449128-1	1988	Monoclonal antibody (MAb) R24 was previously shown to be directed toward ganglioside GD3 [Pukel, C. S., Lloyd, K. O., Travassos, L. R., Dippold, W. G., Oettgen, H. F., and Old, L. J.	Gangliosides	73-84	GRDX	Homo sapiens	85-88
3287805-6	1988	Gangliosides of type II or type III and D-galactose only slightly decreased the ETA-gold binding.	Gangliosides	0-12	endothelin receptor type A	Homo sapiens	80-83
3213581-0	1988	Ganglioside potentiation of NGF-independent conditioned medium enhancement of neuritic outgrowth from spinal cord and ciliary ganglia explants.	Gangliosides	0-11	nerve growth factor	Gallus gallus	28-31
3213581-2	1988	The addition of a mixture of bovine brain gangliosides (BBG) or the monosialoganglioside GM1 to this medium potentiated the nerve growth factor (NGF)-independent CM-mediated neuritogenesis.	Gangliosides	42-54	nerve growth factor	Bos taurus	124-143
3213581-2	1988	The addition of a mixture of bovine brain gangliosides (BBG) or the monosialoganglioside GM1 to this medium potentiated the nerve growth factor (NGF)-independent CM-mediated neuritogenesis.	Gangliosides	42-54	nerve growth factor	Bos taurus	145-148
2908575-6	1988	One cell-substrate interacting antigen, the GD2/GD3 ganglioside, appears to play a critical role in the metastatic process of melanoma cells.	Gangliosides	52-63	GRDX	Homo sapiens	48-51
3162909-3	1988	Gangliosides GD1a and N-acetylgalactosaminyl-GD1a, followed by GM1a and GM2, were the main gangliosides in undifferentiated Friend cells.	Gangliosides	91-103	cytochrome b5 domain containing 2	Mus musculus	72-75
2824382-0	1987	Antigenic structure of Clostridium botulinum type B neurotoxin and its interaction with gangliosides, cerebroside, and free fatty acids.	Gangliosides	88-100	neurotoxin	Clostridium botulinum	52-62
2824382-6	1987	The manner of binding of type B neurotoxin to gangliosides and free fatty acids was different from those of type A and E neurotoxins.	Gangliosides	46-58	neurotoxin	Clostridium botulinum	32-42
2824224-3	1987	More than 95% cells of a Ltk- cell line (thymidine kinase-deficient cells) transiently expressed thymidine kinase activity by thymidine kinase gene transfer using HVJ liposomes with gangliosides.	Gangliosides	182-194	leukocyte receptor tyrosine kinase	Homo sapiens	25-28
2446330-5	1987	Resistance to oxidation by sodium periodate and reformation of the epitope by chemical acetylation of base-treated gangliosides with N-acetylimidazole identify the antigen as 9-O-acetyl GD3.	Gangliosides	115-127	GRDX	Homo sapiens	186-189
2960731-0	1987	Gangliosides induce selective modulation of CD4 from helper T lymphocytes.	Gangliosides	0-12	Cd4 molecule	Rattus norvegicus	44-47
2960731-2	1987	Previously, we found that gangliosides inhibited the function of rat T helper cell lines, and simultaneously inhibited the expression of the rat CD4 molecule identified by the W3/25 antibody.	Gangliosides	26-38	Cd4 molecule	Rattus norvegicus	145-148
2960731-3	1987	We have now evaluated the generality and mechanism(s) of ganglioside-induced modulation of CD4 expressed by mouse, rat, and human T helper lymphocytes.	Gangliosides	57-68	CD4 antigen	Mus musculus	91-94
2960731-4	1987	Ganglioside pretreatment induced rapid and selective disappearance of the CD4 molecule from T helper cells of all three species.	Gangliosides	0-11	Cd4 molecule	Rattus norvegicus	74-77
2960731-6	1987	CD4 modulation appeared to be a general property of gangliosides since the effect could be induced similarly by highly purified individual gangliosides with varying amounts of sialic acid, or by mixed gangliosides.	Gangliosides	52-64	Cd4 molecule	Rattus norvegicus	0-3
2960731-6	1987	CD4 modulation appeared to be a general property of gangliosides since the effect could be induced similarly by highly purified individual gangliosides with varying amounts of sialic acid, or by mixed gangliosides.	Gangliosides	139-151	Cd4 molecule	Rattus norvegicus	0-3
2960731-6	1987	CD4 modulation appeared to be a general property of gangliosides since the effect could be induced similarly by highly purified individual gangliosides with varying amounts of sialic acid, or by mixed gangliosides.	Gangliosides	139-151	Cd4 molecule	Rattus norvegicus	0-3
2960731-8	1987	Gangliosides did not inactivate antibody function, but prevented binding at the cell surface by 12 different monoclonal antibodies specific for a variety of different CD4 epitopes.	Gangliosides	0-12	Cd4 molecule	Rattus norvegicus	167-170
3117976-1	1987	The effects of ganglioside supplementation of culture medium on monoamine oxidase (MAO) type A and B activities in a rat clonal pheochromocytoma cell line, PC12h, were examined.	Gangliosides	15-26	monoamine oxidase A	Rattus norvegicus	64-100
3117976-3	1987	After supplementation of the culture medium with ganglioside GM1, the PC12 cells were found to express type B MAO activity after 4 days of culture, and the amount of type B activity increased with the number of days of culture.	Gangliosides	49-60	monoamine oxidase A	Rattus norvegicus	110-113
3117976-6	1987	Among gangliosides tested GM1 was the most effective in causing expression of type B MAO activity, whereas nerve growth factor was not effective.	Gangliosides	6-18	monoamine oxidase A	Rattus norvegicus	85-88
3117976-7	1987	These results suggest that GM1 and other gangliosides may be involved in the expression of type B MAO in nerve cells and in the regulation of levels of the biogenic amines in the brain.	Gangliosides	41-53	monoamine oxidase A	Rattus norvegicus	98-101
3689771-8	1987	Transfer protein II appeared to be somewhat more specific for neutral glycolipids in that GA1 was transferred more rapidly than any of the gangliosides; however, lactosylceramide transfer was relatively slow.	Gangliosides	139-151	annexin A4	Bos taurus	9-19
2960731-11	1987	These results indicate that gangliosides induce a profound change in the molecular orientation of CD4 within the T helper cell membrane which renders epitopes on the CD4 molecule inaccessible to antibody.	Gangliosides	28-40	Cd4 molecule	Rattus norvegicus	98-101
2960731-11	1987	These results indicate that gangliosides induce a profound change in the molecular orientation of CD4 within the T helper cell membrane which renders epitopes on the CD4 molecule inaccessible to antibody.	Gangliosides	28-40	Cd4 molecule	Rattus norvegicus	166-169
2960731-12	1987	This ganglioside effect represents a novel pathway which may contribute to the understanding of the role of CD4 as a regulatory molecule and as a specific receptor for the acquired immune deficiency syndrome virus.	Gangliosides	5-16	Cd4 molecule	Rattus norvegicus	108-111
3501786-7	1987	The long-chain bases of these four gangliosides consisted of C18-sphingosine and C18-phytosphingosine together with significant amounts of C16 to C19 dihydroxy and trihydroxy bases with iso and anteiso structures.	Gangliosides	35-47	Bardet-Biedl syndrome 9	Homo sapiens	61-64
3501786-7	1987	The long-chain bases of these four gangliosides consisted of C18-sphingosine and C18-phytosphingosine together with significant amounts of C16 to C19 dihydroxy and trihydroxy bases with iso and anteiso structures.	Gangliosides	35-47	Bardet-Biedl syndrome 9	Homo sapiens	81-84
3115774-4	1987	Analysis of the resulting enzyme activities and of the reaction products revealed different substrate specificities for GM2 and GD3 synthase although the normal glycolipid acceptor for both transferases is ganglioside GM3.	Gangliosides	206-217	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	128-140
3622519-3	1987	The main aortic gangliosides were identified as GM3, GM1, GD3, GD1a and GT1b.	Gangliosides	16-28	GRDX	Homo sapiens	58-61
2956143-5	1987	Therefore, the beneficial effect of gangliosides described in C57Bl/Ks (db/db) mice on electrophysiological and morphometrical parameters must be due to different pharmacological activities rather than to prevention of the decay or better maintenance of ATPase activity.	Gangliosides	36-48	dynein, axonemal, heavy chain 8	Mus musculus	254-260
3622519-5	1987	The latter was characterized by high content of GD3, a ganglioside thought to be associated with membrane permeability, cell interaction, adhesiveness and growth and to suppress unspecific immune responses.	Gangliosides	55-66	GRDX	Homo sapiens	48-51
2957431-0	1987	Interleukin 3-dependent mouse mast cells express the cholera toxin-binding acidic glycosphingolipid, ganglioside GM1, and increase their histamine content in response to toxin.	Gangliosides	101-112	interleukin 3	Mus musculus	0-13
3121645-0	1987	Ganglioside inhibition of attachment and differentiation of cultured rat granulosa cells: interactions with fibronectin.	Gangliosides	0-11	fibronectin 1	Rattus norvegicus	108-119
3121645-10	1987	These results suggest that gangliosides inhibit attachment of granulosa cells in culture by binding to fibronectin, whereas the inhibition of FSH-dependent differentiation occurs by other modes of action that are unrelated to the effects on cell adhesion.	Gangliosides	27-39	fibronectin 1	Rattus norvegicus	103-114
3625258-1	1987	The murine IgG3 monoclonal antibody (MoAb) 3F8, specific for the ganglioside GD2, activates human complement, is active in antibody-dependent cell-mediated cytotoxicity (ADCC), and can target specifically to human neuroblastoma in patients with metastatic disease.	Gangliosides	65-76	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	11-15
2957431-0	1987	Interleukin 3-dependent mouse mast cells express the cholera toxin-binding acidic glycosphingolipid, ganglioside GM1, and increase their histamine content in response to toxin.	Gangliosides	101-112	coenzyme Q10A	Mus musculus	113-116
2957431-2	1987	Ganglioside GM1 and other acidic glycosphingolipids were isolated from BMMC by chloroform/methanol extraction and chromatography on DEAE-Sephadex and were analyzed by thin layer chromatography.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-15
2957431-4	1987	As assessed by fluorescence flow cytometric analysis of the binding of fluorescein-conjugated cholera toxin B subunit, the majority of BMMC expressed ganglioside GM1 on their surface, and the total presentation per cell increased as cells progressed from the G1 to S to G2 + M phases of the cell cycle.	Gangliosides	150-161	coenzyme Q10A	Mus musculus	162-165
2957431-10	1987	Preincubation of whole cholera toxin with purified ganglioside GM1 inhibited the histamine-augmenting effects of cholera toxin on BMMC, indicating that the effect was not due to a contaminant, and neither the A nor B subunit of cholera toxin alone increased the histamine content of BMMC.	Gangliosides	51-62	coenzyme Q10A	Mus musculus	63-66
3035998-0	1987	Inactivation of GM1-ganglioside beta-galactosidase by a specific inhibitor: a model for ganglioside storage disease.	Gangliosides	20-31	galactosidase beta 1	Homo sapiens	32-50
3476926-4	1987	We analyzed NIH 3T3 cells transfected with human H-, K- and N-ras oncogenes for their glycolipid composition and expression of cell surface gangliosides.	Gangliosides	140-152	NRAS proto-oncogene, GTPase	Homo sapiens	49-65
3581087-10	1987	GM3, which migrates as double bands on thin-layer chromatography, is the predominant ganglioside of this tumor in all three regions of growth.	Gangliosides	85-96	granulocyte macrophage antigen 3	Mus musculus	0-3
3581087-11	1987	Also present in all regions are gangliosides NGNA-GM3 and GM1.	Gangliosides	32-44	granulocyte macrophage antigen 3	Mus musculus	50-53
3663759-2	1987	The placenta was found to contain three types of gangliosides with oligosaccharide chains Lac, GgOse4 and nLcOse4.	Gangliosides	49-61	lactase	Homo sapiens	90-93
3604057-6	1987	Susceptibility to infection was fully restored after incubation of neuraminidase-treated cells with bovine brain gangliosides known to contain Neu5,9Ac2.	Gangliosides	113-125	neuraminidase 1	Bos taurus	67-80
3571288-2	1987	mAb 202 reacted with two (GM2 and GM3) of the four (GM2, GM3, GD2, and GD3) gangliosides expressed by M14.	Gangliosides	76-88	GRDX	Homo sapiens	71-74
2435716-7	1987	Binding is abolished by treatment of the gangliosides with neuraminidase.	Gangliosides	41-53	neuraminidase 1	Homo sapiens	59-72
2436818-1	1987	In a previous work we have reported that gangliosides inhibit interleukin 1 (IL-1) release by human monocytes stimulated with lipopolysaccharides (LPS).	Gangliosides	41-53	interleukin 1 alpha	Homo sapiens	77-81
2436818-2	1987	In the present study we extend this work to IL-1 production and we correlate these observations with the capacity of gangliosides to inhibit the binding of radiolabeled LPS to its specific receptor on human monocytes.	Gangliosides	117-129	interleukin 1 alpha	Homo sapiens	44-48
2436818-0	1987	Inhibition by gangliosides of the specific binding of lipopolysaccharide (LPS) to human monocytes prevents LPS-induced interleukin-1 production.	Gangliosides	14-26	interleukin 1 alpha	Homo sapiens	119-132
3593794-5	1987	The data obtained indicate that gangliosides interact with apolipoprotein B via specific binding sites.	Gangliosides	32-44	apolipoprotein B	Homo sapiens	59-75
2951267-7	1987	When substrata coated with chymotrypsin-liberated HBF were tested in a similar fashion, adherence was rapid but neurite outgrowth required much longer times and was completely sensitive to RGDS peptides; supplementation of cells with the complex ganglioside GT1b could not induce RGDS-resistant neurites on heparin-binding fragments (HBF).	Gangliosides	246-257	ral guanine nucleotide dissociation stimulator	Homo sapiens	189-193
2951267-7	1987	When substrata coated with chymotrypsin-liberated HBF were tested in a similar fashion, adherence was rapid but neurite outgrowth required much longer times and was completely sensitive to RGDS peptides; supplementation of cells with the complex ganglioside GT1b could not induce RGDS-resistant neurites on heparin-binding fragments (HBF).	Gangliosides	246-257	ral guanine nucleotide dissociation stimulator	Homo sapiens	280-284
3493067-6	1987	Neuraminidase treatment of the latter ganglioside yielded GM3 and lactosyl ceramide, hydrolysis products of GD3.	Gangliosides	38-49	GRDX	Homo sapiens	108-111
3493067-10	1987	The results demonstrate a consistently significant increase in ganglioside GD3 in uncultured, patient-derived T-cell ALL lymphoblasts when compared to non-T-cell ALL and normal lymphoid tissue.	Gangliosides	63-74	GRDX	Homo sapiens	75-78
3815333-1	1987	A monoclonal antibody is described that specifically detects the ganglioside antigens GD2 and GD3, binding preferentially to GD2, in melanoma.	Gangliosides	65-76	GRDX	Homo sapiens	94-97
3805726-0	1987	Approaches to augmenting the immunogenicity of the ganglioside GM2 in mice: purified GM2 is superior to whole cells.	Gangliosides	51-62	cytochrome b5 domain containing 2	Mus musculus	63-66
3805726-0	1987	Approaches to augmenting the immunogenicity of the ganglioside GM2 in mice: purified GM2 is superior to whole cells.	Gangliosides	51-62	cytochrome b5 domain containing 2	Mus musculus	85-88
3805726-1	1987	The gangliosides GM2, GD2, and GD3 are differentiation antigens largely restricted to cells of neuroectodermal origin.	Gangliosides	4-16	cytochrome b5 domain containing 2	Mus musculus	17-20
2435716-8	1987	In solid-phase radioimmunoassay, Leo Mel 3 binds strongly to ganglioside GD2 and less strongly to gangliosides GT3, GD3, and GQ1b.	Gangliosides	61-72	GRDX	Homo sapiens	116-119
3106281-8	1987	Three species of antigenic gangliosides in pooled meconium were tentatively identified as GM3(NeuGc), sialylparagloboside and sialylhexaosylceramide on the basis of their migration positions on 2d-TLC and the results of endo-beta-galactosidase treatment.	Gangliosides	27-39	galactosidase beta 1	Homo sapiens	225-243
2434483-7	1987	Modulation of the phosphorylation of MBP by gangliosides varies with the states of phosphorylation of this protein.	Gangliosides	44-56	myelin basic protein	Cavia porcellus	37-40
3818942-1	1987	Serum from a patient with IgM paraproteinemia and polyradiculoneuropathy, diagnosed as malignant lymphoma, reacted specifically with a ganglioside, sialosyllactosaminylparagloboside (SLPG), in human peripheral nerve but not with myelin-associated glycoprotein (MAG).	Gangliosides	135-146	myelin associated glycoprotein	Homo sapiens	229-259
3818942-1	1987	Serum from a patient with IgM paraproteinemia and polyradiculoneuropathy, diagnosed as malignant lymphoma, reacted specifically with a ganglioside, sialosyllactosaminylparagloboside (SLPG), in human peripheral nerve but not with myelin-associated glycoprotein (MAG).	Gangliosides	135-146	myelin associated glycoprotein	Homo sapiens	261-264
3570695-10	1987	A similar pattern of transient appearance of highly sialylated gangliosides seen previously on days 14-17 leads to an hypothesis of a structural linkage between acetylcholinesterase and the plasma membrane lipids of corneal epithelial cells.	Gangliosides	63-75	acetylcholinesterase (Cartwright blood group)	Gallus gallus	161-181
2434489-4	1987	The transition temperature of gangliosides increases in the presence of MBP, whereas that of sulfatide decreases.	Gangliosides	30-42	myelin basic protein	Homo sapiens	72-75
2434483-8	1987	Prior addition of ganglioside to myelin inhibited the phosphorylation of MBP.	Gangliosides	18-29	myelin basic protein	Cavia porcellus	73-76
2434483-10	1987	Phosphorylation of isolated MBP by protein kinase C was stimulated by gangliosides, provided phosphatidylserine was present.	Gangliosides	70-82	myelin basic protein	Cavia porcellus	28-31
3566706-1	1987	The four major isoelectric forms of human liver neuraminidase (with pI values between 3.4 and 4.8) have been isolated by preparative isoelectric focusing and characterized with regard to their substrate specificity using glycoprotein, glycopeptide, oligosaccharide and ganglioside natural substrates.	Gangliosides	269-280	neuraminidase 1	Homo sapiens	48-61
3037840-6	1987	However, rabbits inoculated with FCA, gangliosides, lecithin and cholesterol had rising titers of antibody to both MBP and GC over the 3-month experimental period.	Gangliosides	38-50	myelin basic protein	Oryctolagus cuniculus	115-118
3554791-4	1987	Total ganglioside content was reduced in epileptic hippocampi, which was attributable, in part, to pyramidal cell loss found in CA1 and CA3.	Gangliosides	6-17	carbonic anhydrase 1	Homo sapiens	128-131
3554791-4	1987	Total ganglioside content was reduced in epileptic hippocampi, which was attributable, in part, to pyramidal cell loss found in CA1 and CA3.	Gangliosides	6-17	carbonic anhydrase 3	Homo sapiens	136-139
3554791-5	1987	In each case, the percentage of ganglioside GD3 was increased significantly, while ganglioside GD1a decreased.	Gangliosides	32-43	GRDX	Homo sapiens	44-47
2433055-0	1987	Gangliosides suppress the proliferation of autoreactive cells in experimental allergic encephalomyelitis: ganglioside effects on IL-2 activity.	Gangliosides	106-117	interleukin 2	Rattus norvegicus	129-133
2433055-4	1987	Gangliosides similarly inhibited the antigen-induced proliferation of a myelin basic protein (MBP)-reactive T-cell line which is able to passively induce EAE.	Gangliosides	0-12	myelin basic protein	Rattus norvegicus	72-92
2433055-4	1987	Gangliosides similarly inhibited the antigen-induced proliferation of a myelin basic protein (MBP)-reactive T-cell line which is able to passively induce EAE.	Gangliosides	0-12	myelin basic protein	Rattus norvegicus	94-97
2433055-10	1987	Addition of exogenous IL-2 to ganglioside-suppressed cultures had no effect or only partially restored the proliferative responses.	Gangliosides	30-41	interleukin 2	Rattus norvegicus	22-26
3100066-8	1987	Inhibition was much more effective if the gangliosides were preincubated with IL-2 before addition of cells, but no inhibition was observed if the cells were preincubated with gangliosides and the unbound gangliosides were washed out prior to addition of the IL-2.	Gangliosides	42-54	interleukin 2	Mus musculus	78-82
3100066-7	1987	Binding of 125I-labeled recombinant IL-2 to cells cultured for 48 hr with Con A was inhibited by ganglioside GD1a but not by asialo GM1.	Gangliosides	97-108	interleukin 2	Mus musculus	36-40
3022915-0	1986	Potentiation of lymphocyte responses by monoclonal antibodies to the ganglioside GD3.	Gangliosides	69-80	GRDX	Homo sapiens	81-84
3493846-0	1987	Enhancement of cytotoxic and proliferative responses of lymphocytes from melanoma patients by incubation with monoclonal antibodies against ganglioside GD3.	Gangliosides	140-151	GRDX	Homo sapiens	152-155
3493846-1	1987	Previous studies have shown that monoclonal antibodies (M.Ab) to the ganglioside GD3 may induce partial remissions in tumour growth in patients with melanoma.	Gangliosides	69-80	GRDX	Homo sapiens	81-84
3030576-3	1986	Using this approach, specific gangliosides have been identified as the receptors for certain bacterial toxins and viruses and as important factors in the organization of fibronectin into an extracellular matrix.	Gangliosides	30-42	fibronectin 1	Homo sapiens	170-181
3623637-0	1987	A quantitative analysis of H-2 linked effects on hepatic ganglioside composition.	Gangliosides	57-68	histocompatibility-2, MHC	Mus musculus	27-30
3623637-2	1987	An analysis of variance of replicate samples of liver from strains B10, B10.A, and B10.G revealed that the time of sample and colony of origin were not sources of significant variance but that for N-glycolylated gangliosides GM2, GM1, and GD1a, the differences detected between strains were significant.	Gangliosides	212-224	cytochrome b5 domain containing 2	Mus musculus	225-228
3022915-1	1986	Previous studies have shown that the ganglioside GD3 is expressed in high concentrations on melanoma cells and that monoclonal antibodies (MAbs) against GD3 may induce partial remissions in tumor growth in patients with melanoma.	Gangliosides	37-48	GRDX	Homo sapiens	49-52
3022915-1	1986	Previous studies have shown that the ganglioside GD3 is expressed in high concentrations on melanoma cells and that monoclonal antibodies (MAbs) against GD3 may induce partial remissions in tumor growth in patients with melanoma.	Gangliosides	37-48	GRDX	Homo sapiens	153-156
3022915-2	1986	The present studies indicated that incubation of interleukin 2 (IL2) dependent murine natural killer cells with several MAbs against the ganglioside GD3 potentiated the proliferative response to IL2.	Gangliosides	137-148	interleukin 2	Mus musculus	49-62
3505365-0	1987	Effects of fimbria-fornix transection and ganglioside treatments on histochemical staining for glucose-6-phosphate dehydrogenase in the lateral septum.	Gangliosides	42-53	glucose-6-phosphate dehydrogenase	Rattus norvegicus	95-128
3505365-1	1987	The present study examined whether ganglioside treatments would affect an enzyme marker (glucose-6-phosphate dehydrogenase; G6PDH) of neural metabolism in an established model system (the hippocamposeptal projection) of deafferentation and sprouting.	Gangliosides	35-46	glucose-6-phosphate dehydrogenase	Rattus norvegicus	89-122
3022915-2	1986	The present studies indicated that incubation of interleukin 2 (IL2) dependent murine natural killer cells with several MAbs against the ganglioside GD3 potentiated the proliferative response to IL2.	Gangliosides	137-148	interleukin 2	Mus musculus	64-67
3022915-2	1986	The present studies indicated that incubation of interleukin 2 (IL2) dependent murine natural killer cells with several MAbs against the ganglioside GD3 potentiated the proliferative response to IL2.	Gangliosides	137-148	GRDX	Homo sapiens	149-152
3022915-2	1986	The present studies indicated that incubation of interleukin 2 (IL2) dependent murine natural killer cells with several MAbs against the ganglioside GD3 potentiated the proliferative response to IL2.	Gangliosides	137-148	interleukin 2	Mus musculus	195-198
3029046-5	1986	The structure of this ganglioside Gx fraction was elucidated by thin-layer chromatography, sugar analysis, neuraminidase digestion, and permethylation studies.	Gangliosides	22-33	neuraminidase 1	Bos taurus	107-120
3548172-3	1986	The preliminary treatment of gangliosides with neuraminidase enhances the sensitivity of this assay.	Gangliosides	29-41	neuraminidase 1	Homo sapiens	47-60
3533633-2	1986	The GD2 ganglioside and N-acetylgalactosaminyl transferase, which catalyzes the biosynthesis of GD2 from its precursor GD3, were detected in cultures established from advanced primary and metastatic melanomas, but not in cultures of normal melanocytes.	Gangliosides	8-19	GRDX	Homo sapiens	119-122
3777945-7	1986	Inhibition of binding by gangliosides is not due to competition for adsorption to the plastic, as preincubation of the adsorbed lipids with neuraminidase reverses inhibition by GM3, but not by GM1 which is not a substrate for the enzyme.	Gangliosides	25-37	neuraminidase 1	Homo sapiens	140-153
3768389-2	1986	GD3 in colostrum, particularly in the early period of lactation, was the major ganglioside, and the molar ratio of GM3 to GD3 was 0.2-0.3 in the milk at 2-6 days postpartum.	Gangliosides	79-90	GRDX	Homo sapiens	0-3
3774158-1	1986	The effect of nerve growth factor treatment on the expression of neutral glycosphingolipids and gangliosides was examined in PC12 pheochromocytoma cells grown in spinner culture.	Gangliosides	96-108	nerve growth factor	Rattus norvegicus	14-33
3774158-7	1986	Studies using [3H]fucose to examine the synthesis of fucosylglycolipids indicate that nerve growth factor enhances the incorporation of fucose into glycolipids and gangliosides by as much as 80%.	Gangliosides	164-176	nerve growth factor	Rattus norvegicus	86-105
3774158-8	1986	These studies show that all of the gangliosides in PC12 cells appear to increase in concentration when the cells are treated with nerve growth factor in spinner culture.	Gangliosides	35-47	nerve growth factor	Rattus norvegicus	130-149
3490279-0	1986	[Gangliosides of murine B-lymphoma MORC-406].	Gangliosides	1-13	microrchidia 1	Mus musculus	35-39
3782071-0	1986	Synergistic effects of the myc and ras oncogenes on ganglioside synthesis by BALB/c 3T3 fibroblasts.	Gangliosides	52-63	myelocytomatosis oncogene	Mus musculus	27-30
3731079-1	1986	Antisera reactive with the ganglioside GM2 were raised by immunizing C57BL/6 mice with the C57BL/6 melanoma JB-RH.	Gangliosides	27-38	cytochrome b5 domain containing 2	Mus musculus	39-42
3768889-5	1986	Ganglioside mapping showed that there was polymorphic variation of gangliosides in the liver of inbred strains of mice and that the major gangliosides were GM3(NeuGc) in WHT/Ht, GM2(NeuGc) in BALB/c and C3H/He, and GM2(NeuGc), GM1(NeuGc), and GDla(NeuGc, NeuGc) in ICR mice.	Gangliosides	138-150	granulocyte macrophage antigen 3	Mus musculus	156-166
3087662-1	1986	The internalization of exogenous mixed brain gangliosides in ML IV cultured skin fibroblasts indicated an impairment of ganglioside catabolism in these cells.	Gangliosides	45-57	mucolipin TRP cation channel 1	Homo sapiens	61-66
3527721-0	1986	Inhibition of lipopolysaccharide-induced monocyte interleukin 1 secretion by gangliosides.	Gangliosides	77-89	interleukin 1 alpha	Homo sapiens	50-63
3527721-1	1986	Gangliosides known to be potent immunosuppressors are shown to inhibit the secretion of interleukin 1 (IL 1) by human monocytes stimulated with lipopolysaccharide (LPS).	Gangliosides	0-12	interleukin 1 alpha	Homo sapiens	88-107
3527721-3	1986	The inhibition of LPS-induced IL 1 secretion was obtained in the presence of indomethacin, indicating that the ganglioside inhibitory capacity was not due to prostaglandin induction.	Gangliosides	111-122	interleukin 1 alpha	Homo sapiens	30-34
2426301-4	1986	Release of IL-2 could be detected after incubation of these CSF lines with specific gangliosides.	Gangliosides	84-96	interleukin 2	Homo sapiens	11-15
3087662-2	1986	Incubation of ML IV, normal and various other lysosomal storage disorders cell lines for five days with exogenous tritium labelled GM3, GD1a or GT1 gangliosides allowed accurate quantitation of the retained gangliosides.	Gangliosides	148-160	mucolipin TRP cation channel 1	Homo sapiens	14-19
3746324-0	1986	Brain gangliosides in the presenile dementia of Pick.	Gangliosides	6-18	protein interacting with PRKCA 1	Homo sapiens	48-52
3746324-1	1986	Histochemical analysis of frontal and temporal lobes from four patients with Pick presenile dementia indicated intracellular and extracellular deposits of gangliosides.	Gangliosides	155-167	protein interacting with PRKCA 1	Homo sapiens	77-81
3746324-2	1986	Thin layer chromatography of gangliosides disclosed the presence of an unknown ganglioside, a decrease of N-acetylgalactosamine-GDla and an increase of GTla and/or GD2 in white matter of Pick brain.	Gangliosides	29-41	protein interacting with PRKCA 1	Homo sapiens	187-191
3746324-2	1986	Thin layer chromatography of gangliosides disclosed the presence of an unknown ganglioside, a decrease of N-acetylgalactosamine-GDla and an increase of GTla and/or GD2 in white matter of Pick brain.	Gangliosides	29-40	protein interacting with PRKCA 1	Homo sapiens	187-191
3746324-4	1986	It is suggested that degradation and removal of gangliosides is incomplete in Pick disease.	Gangliosides	48-60	protein interacting with PRKCA 1	Homo sapiens	78-82
3087662-1	1986	The internalization of exogenous mixed brain gangliosides in ML IV cultured skin fibroblasts indicated an impairment of ganglioside catabolism in these cells.	Gangliosides	45-56	mucolipin TRP cation channel 1	Homo sapiens	61-66
3708379-3	1986	In addition, the interaction of each ganglioside with nerve growth factor (NGF) was investigated with an NGF-responsive pheochromocytoma PC12 cell line and NGF-insensitive neuroblastoma Neuro-2a cultures.	Gangliosides	37-48	nerve growth factor	Rattus norvegicus	54-73
3709810-0	1986	TLC immunostaining characterization of Clostridium botulinum type A neurotoxin binding to gangliosides and free fatty acids.	Gangliosides	90-102	neurotoxin	Clostridium botulinum	68-78
3709810-3	1986	Optimum binding of neurotoxin to the ganglioside appeared in 0.01 M phosphate buffer (pH 7.2) containing 0.2% NaCl.	Gangliosides	37-48	neurotoxin	Clostridium botulinum	19-29
3709810-4	1986	Higher and lower NaCl concentrations diminished neurotoxin binding to the ganglioside.	Gangliosides	74-85	neurotoxin	Clostridium botulinum	48-58
3087662-2	1986	Incubation of ML IV, normal and various other lysosomal storage disorders cell lines for five days with exogenous tritium labelled GM3, GD1a or GT1 gangliosides allowed accurate quantitation of the retained gangliosides.	Gangliosides	148-160	beta-1,4-galactosyltransferase 1	Homo sapiens	144-147
3708379-3	1986	In addition, the interaction of each ganglioside with nerve growth factor (NGF) was investigated with an NGF-responsive pheochromocytoma PC12 cell line and NGF-insensitive neuroblastoma Neuro-2a cultures.	Gangliosides	37-48	nerve growth factor	Rattus norvegicus	75-78
3524865-3	1986	ChAT-positive neurons also were stained for ganglioside GM1 by using an avidin-biotin complex technique.	Gangliosides	44-55	choline O-acetyltransferase	Rattus norvegicus	0-4
3708379-4	1986	PC12 cells responded to gangliosides only in the presence of NGF (20 micrograms/ml): GM1 produced the greatest morphologic response, but did not alter metabolic levels; GT1b increased both parameters.	Gangliosides	24-36	nerve growth factor	Rattus norvegicus	61-64
3708379-8	1986	In addition, it is possible to confer a sensitivity to NGF by simultaneous treatment with specific gangliosides.	Gangliosides	99-111	nerve growth factor	Rattus norvegicus	55-58
3700477-0	1986	Fibrillar organization of fibronectin is expressed coordinately with cell surface gangliosides in a variant murine fibroblast.	Gangliosides	82-94	fibronectin 1	Mus musculus	26-37
3700477-2	1986	When the cells are exposed to exogenous gangliosides, fibrillar strands of fibronectin become attached to the cell surface.	Gangliosides	40-52	fibronectin 1	Mus musculus	75-86
3700477-6	1986	The variant had much more surface gangliosides than the parental, particularly more complex gangliosides corresponding to GM1 and GD1a.	Gangliosides	34-46	coenzyme Q10A	Mus musculus	122-125
3700477-6	1986	The variant had much more surface gangliosides than the parental, particularly more complex gangliosides corresponding to GM1 and GD1a.	Gangliosides	92-104	coenzyme Q10A	Mus musculus	122-125
3700477-8	1986	By using sialidase, which hydrolyzes GD1a to GM1, and 125I-labeled cholera toxin, which binds specifically to GM1, the identity and levels of these gangliosides were confirmed in the three cell types.	Gangliosides	148-160	coenzyme Q10A	Mus musculus	110-113
3700477-13	1986	Our results further establish that the ability of a cell to organize fibronectin into an extracellular matrix is dependent on certain gangliosides, but they also indicate that cell adhesion to fibronectin is independent of these gangliosides.	Gangliosides	134-146	fibronectin 1	Mus musculus	69-80
3714350-7	1986	The predominating ganglioside in human milk, monosialoganglioside 3 (74% of total gangliosides), was only a minor component (3%) of bovine milk gangliosides.	Gangliosides	82-94	Weaning weight-maternal milk	Bos taurus	39-43
3714350-8	1986	Disialoganglioside 3 represented 80% of bovine milk gangliosides compared to 25% of the human milk gangliosides.	Gangliosides	52-64	Weaning weight-maternal milk	Bos taurus	47-51
3714350-2	1986	Human milk gangliosides showed considerably higher enterotoxin-inhibitory activity compared to bovine and formula milk gangliosides as measured in vitro by enzyme-linked immunosorbent assay and in vivo in rabbit small bowel loops.	Gangliosides	11-23	Weaning weight-maternal milk	Bos taurus	6-10
3714350-8	1986	Disialoganglioside 3 represented 80% of bovine milk gangliosides compared to 25% of the human milk gangliosides.	Gangliosides	99-111	Weaning weight-maternal milk	Bos taurus	94-98
3714350-2	1986	Human milk gangliosides showed considerably higher enterotoxin-inhibitory activity compared to bovine and formula milk gangliosides as measured in vitro by enzyme-linked immunosorbent assay and in vivo in rabbit small bowel loops.	Gangliosides	119-131	Weaning weight-maternal milk	Bos taurus	114-118
3714350-11	1986	We conclude that the higher nonimmunoglobulin enterotoxin-inhibitory activity in human milk compared to bovine milk is associated with the differences in the ganglioside fraction.	Gangliosides	158-169	Weaning weight-maternal milk	Bos taurus	87-91
3714350-3	1986	While gangliosides from less than 1 ml human milk inhibited 0.1 microgram choleratoxin in vitro and in vivo, five to 10 times higher amounts of bovine milk gangliosides were necessary to achieve similar results.	Gangliosides	6-18	Weaning weight-maternal milk	Bos taurus	45-49
3714350-4	1986	Analysis of the ganglioside composition in human, bovine, and bovine milk-based formula milk showed that the ganglioside patterns in human and bovine milk differed markedly.	Gangliosides	16-27	Weaning weight-maternal milk	Bos taurus	88-92
3714350-4	1986	Analysis of the ganglioside composition in human, bovine, and bovine milk-based formula milk showed that the ganglioside patterns in human and bovine milk differed markedly.	Gangliosides	16-27	Weaning weight-maternal milk	Bos taurus	88-92
3714350-5	1986	The ganglioside patterns of bovine milk and formula milk appeared identical.	Gangliosides	4-15	Weaning weight-maternal milk	Bos taurus	35-39
3714350-5	1986	The ganglioside patterns of bovine milk and formula milk appeared identical.	Gangliosides	4-15	Weaning weight-maternal milk	Bos taurus	52-56
3714350-6	1986	In human or bovine milk, the total amount of gangliosides was 11 mg/liter compared to 6 mg/liter in formula milk.	Gangliosides	45-57	Weaning weight-maternal milk	Bos taurus	19-23
3714350-7	1986	The predominating ganglioside in human milk, monosialoganglioside 3 (74% of total gangliosides), was only a minor component (3%) of bovine milk gangliosides.	Gangliosides	18-29	Weaning weight-maternal milk	Bos taurus	39-43
3714350-11	1986	We conclude that the higher nonimmunoglobulin enterotoxin-inhibitory activity in human milk compared to bovine milk is associated with the differences in the ganglioside fraction.	Gangliosides	158-169	Weaning weight-maternal milk	Bos taurus	111-115
3711245-2	1986	The gangliosides were identified as GD3 and GM3 by methanolysis (2 M hydrochloric acid; 60 or 85 degrees C) and gas chromatography of trifluoroacetate derivatives on a fused-silica capillary column.	Gangliosides	4-16	GRDX	Homo sapiens	36-39
3960319-0	1986	Gangliosides GM1 and GD1b are antigens for IgM M-protein in a patient with motor neuron disease.	Gangliosides	0-12	myomesin 2	Homo sapiens	47-56
3957921-0	1986	Localization of the ganglioside-binding site of fibronectin.	Gangliosides	20-31	fibronectin 1	Homo sapiens	48-59
3957921-1	1986	It has been demonstrated via biological assays that fibronectin possesses a receptor for gangliosides that is involved in cell adhesion and restoration of the normal morphology of transformed cells.	Gangliosides	89-101	fibronectin 1	Homo sapiens	52-63
3957921-5	1986	Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin.	Gangliosides	85-96	fibronectin 1	Homo sapiens	108-119
3957921-5	1986	Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin.	Gangliosides	85-96	fibronectin 1	Homo sapiens	225-236
3957921-5	1986	Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin.	Gangliosides	145-157	fibronectin 1	Homo sapiens	108-119
3943547-0	1986	Fibronectin binding to gangliosides and rat liver plasma membranes.	Gangliosides	23-35	fibronectin 1	Rattus norvegicus	0-11
3957921-5	1986	Using the fluorescence polarization assay developed in this study for measurement of ganglioside binding to fibronectin, it is demonstrated that gangliosides bind to the 31,000-dalton amino terminal heparin-binding domain of fibronectin.	Gangliosides	145-157	fibronectin 1	Homo sapiens	225-236
3957921-6	1986	A ganglioside-Sepharose affinity column has been constructed which specifically binds the 31,000-dalton amino terminal fragment of fibronectin.	Gangliosides	2-13	fibronectin 1	Homo sapiens	131-142
3701369-2	1986	The myelin-specific ganglioside GM4, when incubated with myelin basic protein prior to inoculation, prevents experimental allergic encephalomyelitis in the guinea pig.	Gangliosides	20-31	myelin basic protein	Cavia porcellus	57-77
3005335-1	1986	Human melanoma cells express relatively large amounts of the disialogangliosides GD3 and GD2 on their surface whereas neuroblastoma cells express GD2 as a major ganglioside.	Gangliosides	68-79	GRDX	Homo sapiens	81-84
3005335-3	1986	Cells that are preattached to a fibronectin substrate can also be induced to detach and round up in the presence of purified anti-ganglioside Mab.	Gangliosides	130-141	fibronectin 1	Homo sapiens	32-43
3943547-3	1986	Above a critical ganglioside concentration, the gangliosides bound the fibronectin (GT1b congruent to GD1b congruent to GD1a greater than GM1 much greater than GM2 congruent to GD3 congruent to GM3) in approximately the same order of efficiency as they competed for the cellular sites of fibronectin binding in cell attachment assays (Kleinman et al., Proc natl acad sci US 76 (1979) 3367).	Gangliosides	17-28	fibronectin 1	Rattus norvegicus	71-82
3943547-3	1986	Above a critical ganglioside concentration, the gangliosides bound the fibronectin (GT1b congruent to GD1b congruent to GD1a greater than GM1 much greater than GM2 congruent to GD3 congruent to GM3) in approximately the same order of efficiency as they competed for the cellular sites of fibronectin binding in cell attachment assays (Kleinman et al., Proc natl acad sci US 76 (1979) 3367).	Gangliosides	48-60	fibronectin 1	Rattus norvegicus	71-82
3943547-3	1986	Above a critical ganglioside concentration, the gangliosides bound the fibronectin (GT1b congruent to GD1b congruent to GD1a greater than GM1 much greater than GM2 congruent to GD3 congruent to GM3) in approximately the same order of efficiency as they competed for the cellular sites of fibronectin binding in cell attachment assays (Kleinman et al., Proc natl acad sci US 76 (1979) 3367).	Gangliosides	48-60	fibronectin 1	Rattus norvegicus	288-299
3943547-4	1986	Alternatively, these same gangliosides bound to immobilized fibronectin.	Gangliosides	26-38	fibronectin 1	Rattus norvegicus	60-71
2935542-0	1986	Variants of BALB/c 3T3 cells lacking complex gangliosides retain a fibronectin matrix and spread normally on fibronectin-coated substrates.	Gangliosides	45-57	fibronectin 1	Mus musculus	67-78
3943547-5	1986	Rat erythrocytes coated with gangliosides GM1, GD1a or GT1b bound more fibronectin than erythrocytes not supplemented with gangliosides.	Gangliosides	29-41	fibronectin 1	Rattus norvegicus	71-82
2935542-2	1986	We have therefore tested the ability of variants of BALB/c 3T3 deficient in such gangliosides to organize a fibronectin matrix and to spread on fibronectin-coated substrates.	Gangliosides	81-93	fibronectin 1	Mus musculus	108-119
3943547-6	1986	Using fibronectin in which lysine residues were radioiodinated, an apparent Kd for binding to mixed rat liver gangliosides of 7.8 X 10(-9) M was determined.	Gangliosides	110-122	fibronectin 1	Rattus norvegicus	6-17
3943547-11	1986	Plasma membranes isolated from hepatic tumors in which the higher gangliosides that bind fibronectin were depleted bound 43-75% less [125I]fibronectin than did plasma membranes from control livers.	Gangliosides	66-78	fibronectin 1	Rattus norvegicus	89-100
3079806-0	1986	The suppressive effect of gangliosides upon IL 2-dependent proliferation as a function of inhibition of IL 2-receptor association.	Gangliosides	26-38	interleukin 2	Homo sapiens	44-48
3079806-0	1986	The suppressive effect of gangliosides upon IL 2-dependent proliferation as a function of inhibition of IL 2-receptor association.	Gangliosides	26-38	interleukin 2 receptor subunit beta	Homo sapiens	104-117
3941320-4	1986	NGF stimulates the incorporation of [3H]galactose into gangliosides and other glycolipids and glycoproteins and [14C]acetate into total lipids, regardless of the serum concentration.	Gangliosides	55-67	nerve growth factor	Rattus norvegicus	0-3
3079806-1	1986	Gangliosides inhibited the proliferation of mitogen-activated human peripheral blood lymphocytes and the IL 2-dependent growth of murine T cell lines and 5-day-old human PHA lymphoblasts.	Gangliosides	0-12	interleukin 2	Homo sapiens	105-109
3079806-2	1986	In the case of the murine cell lines and PHA lymphoblasts, most of the effect of gangliosides could be reversed by the addition of high levels of IL 2.	Gangliosides	81-93	interleukin 2	Mus musculus	146-150
3079806-4	1986	These results indicate that inhibition of proliferation by gangliosides can be divided into IL 2-reversible and IL 2-irreversible mechanisms, the latter of which were predominant during the initial stage of cellular activation.	Gangliosides	59-71	interleukin 2	Homo sapiens	92-96
3079806-4	1986	These results indicate that inhibition of proliferation by gangliosides can be divided into IL 2-reversible and IL 2-irreversible mechanisms, the latter of which were predominant during the initial stage of cellular activation.	Gangliosides	59-71	interleukin 2	Homo sapiens	112-116
3079806-5	1986	Inclusion of gangliosides in receptor binding assays for radiolabeled IL 2 indicated that the IL 2-reversible mechanism likely involved competition between gangliosides and the cellular receptor for the binding of IL 2.	Gangliosides	13-25	interleukin 2	Homo sapiens	70-74
3079806-5	1986	Inclusion of gangliosides in receptor binding assays for radiolabeled IL 2 indicated that the IL 2-reversible mechanism likely involved competition between gangliosides and the cellular receptor for the binding of IL 2.	Gangliosides	13-25	interleukin 2	Homo sapiens	94-98
3079806-5	1986	Inclusion of gangliosides in receptor binding assays for radiolabeled IL 2 indicated that the IL 2-reversible mechanism likely involved competition between gangliosides and the cellular receptor for the binding of IL 2.	Gangliosides	13-25	interleukin 2	Homo sapiens	94-98
3079806-5	1986	Inclusion of gangliosides in receptor binding assays for radiolabeled IL 2 indicated that the IL 2-reversible mechanism likely involved competition between gangliosides and the cellular receptor for the binding of IL 2.	Gangliosides	156-168	interleukin 2	Homo sapiens	70-74
3079806-5	1986	Inclusion of gangliosides in receptor binding assays for radiolabeled IL 2 indicated that the IL 2-reversible mechanism likely involved competition between gangliosides and the cellular receptor for the binding of IL 2.	Gangliosides	156-168	interleukin 2	Homo sapiens	94-98
3079806-5	1986	Inclusion of gangliosides in receptor binding assays for radiolabeled IL 2 indicated that the IL 2-reversible mechanism likely involved competition between gangliosides and the cellular receptor for the binding of IL 2.	Gangliosides	156-168	interleukin 2	Homo sapiens	94-98
3079806-6	1986	Gangliosides blocked binding of radiolabeled IL 2 to both the high and low affinity forms of the IL 2 receptor, and this effect was most noticeable when the gangliosides and IL 2 were preincubated before addition of the target cells.	Gangliosides	0-12	interleukin 2	Homo sapiens	45-49
3079806-6	1986	Gangliosides blocked binding of radiolabeled IL 2 to both the high and low affinity forms of the IL 2 receptor, and this effect was most noticeable when the gangliosides and IL 2 were preincubated before addition of the target cells.	Gangliosides	0-12	interleukin 2	Homo sapiens	97-101
3456169-0	1986	Ganglioside GM3: an acidic membrane component that increases during macrophage-like cell differentiation can induce monocytic differentiation of human myeloid and monocytoid leukemic cell lines HL-60 and U937.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
3079806-6	1986	Gangliosides blocked binding of radiolabeled IL 2 to both the high and low affinity forms of the IL 2 receptor, and this effect was most noticeable when the gangliosides and IL 2 were preincubated before addition of the target cells.	Gangliosides	0-12	interleukin 2	Homo sapiens	97-101
3456169-1	1986	When human myeloid and monocytoid leukemic cell lines HL-60 and U937, respectively, were treated with an exogenous sialoglycosphingolipid, ganglioside GM3, in serum-free medium, cell growth was markedly inhibited, and their morphological maturation along a monocytic lineage was observed.	Gangliosides	115-137	granulocyte macrophage antigen 3	Mus musculus	151-154
3079806-6	1986	Gangliosides blocked binding of radiolabeled IL 2 to both the high and low affinity forms of the IL 2 receptor, and this effect was most noticeable when the gangliosides and IL 2 were preincubated before addition of the target cells.	Gangliosides	157-169	interleukin 2	Homo sapiens	45-49
3079806-6	1986	Gangliosides blocked binding of radiolabeled IL 2 to both the high and low affinity forms of the IL 2 receptor, and this effect was most noticeable when the gangliosides and IL 2 were preincubated before addition of the target cells.	Gangliosides	157-169	interleukin 2	Homo sapiens	97-101
3079806-6	1986	Gangliosides blocked binding of radiolabeled IL 2 to both the high and low affinity forms of the IL 2 receptor, and this effect was most noticeable when the gangliosides and IL 2 were preincubated before addition of the target cells.	Gangliosides	157-169	interleukin 2	Homo sapiens	97-101
3079806-8	1986	Gangliosides also blocked the binding of radiolabeled IL 2 to anti-IL 2 antibodies, supporting the notion that their inhibitory effect is mediated via a direct interaction with IL 2.	Gangliosides	0-12	interleukin 2	Homo sapiens	54-58
3079806-8	1986	Gangliosides also blocked the binding of radiolabeled IL 2 to anti-IL 2 antibodies, supporting the notion that their inhibitory effect is mediated via a direct interaction with IL 2.	Gangliosides	0-12	interleukin 2	Homo sapiens	67-71
3079806-8	1986	Gangliosides also blocked the binding of radiolabeled IL 2 to anti-IL 2 antibodies, supporting the notion that their inhibitory effect is mediated via a direct interaction with IL 2.	Gangliosides	0-12	interleukin 2	Homo sapiens	67-71
3079806-9	1986	Thus, one major mechanism by which gangliosides block the IL 2-dependent proliferation of activated cells is by the sequestering or inactivation of the IL 2 molecule.	Gangliosides	35-47	interleukin 2	Homo sapiens	58-62
3079806-9	1986	Thus, one major mechanism by which gangliosides block the IL 2-dependent proliferation of activated cells is by the sequestering or inactivation of the IL 2 molecule.	Gangliosides	35-47	interleukin 2	Homo sapiens	152-156
3079806-10	1986	This effect is reversible with the addition of excess IL 2, which distinguishes it from other mechanisms of ganglioside-dependent inhibition operating during the cellular activation process.	Gangliosides	108-119	interleukin 2	Homo sapiens	54-58
2426214-0	1986	Interaction of gangliosides with fibronectin in the mobilization of capillary endothelium.	Gangliosides	15-27	fibronectin 1	Bos taurus	33-44
3942818-1	1986	Female BALB/c mice were immunized with human melanoma (Mewo) cells containing ganglioside GD3 as a surface antigen.	Gangliosides	78-89	GRDX	Homo sapiens	90-93
3536311-8	1986	On the other hand, inborn metabolic errors causing ganglioside accumulation in neurons (GM1 gangliosides) are correlated to an aberrant neurite outgrowth.	Gangliosides	51-62	coenzyme Q10A	Mus musculus	88-91
3459699-4	1986	The cALL cells contained trace amounts of the ganglioside GD3, a compound present in CLL cells (5.6%) but absent in normal lymphocytes.	Gangliosides	46-57	GRDX	Homo sapiens	58-61
3937073-2	1985	When added at 48 h to established cultures of nerve growth factor (NGF)-dependent neurons, all ganglioside species tested increased the expression of neurofilament protein.	Gangliosides	95-106	nerve growth factor	Gallus gallus	46-65
3937073-2	1985	When added at 48 h to established cultures of nerve growth factor (NGF)-dependent neurons, all ganglioside species tested increased the expression of neurofilament protein.	Gangliosides	95-106	nerve growth factor	Gallus gallus	67-70
4066767-3	1985	Preincubation with 3.0 micrograms/ml ganglioside GM1 at 0 degrees C for 3 hr sensitized the mouse L-cell line to the inhibitor, as determined by protein synthesis assays.	Gangliosides	37-48	coenzyme Q10A	Mus musculus	49-52
4066767-12	1985	Binding of the inhibitor to ganglioside GM1 was first examined after the ganglioside had been preadsorbed to polystyrene tubes.	Gangliosides	28-39	coenzyme Q10A	Mus musculus	40-43
4066767-15	1985	Competition experiments showed that the gangliosides GM1 and GD1a did not neutralize the protein synthesis inhibitory activity of the glycopeptides, indicating that gangliosides do not directly interact with the glycopeptide inhibitor.	Gangliosides	40-52	coenzyme Q10A	Mus musculus	53-56
3904839-0	1985	[Ganglioside GD3 in the serum of tumor patients].	Gangliosides	1-12	GRDX	Homo sapiens	13-16
3935131-4	1985	Normal fibroblasts and fibroblasts of variant B and O of GM2 gangliosidosis secrete GM2-activator protein as a 24-kDa polypeptide, which is able to stimulate degradation of ganglioside GM2 by beta-hexosaminidase A in the in vitro assay.	Gangliosides	173-184	O-GlcNAcase	Homo sapiens	192-211
3932335-6	1985	Acceptor specificity studies indicated that the purified alpha 1----3-galactosyltransferase was free from contaminating galactosyltransferase activities such as those involved in the synthesis of Gal beta 1----4GlcNAc-R and Gal beta 1----3GalNAc-R sequences, the blood group B determinant, the Pk antigen, trihexosylceramide, and ganglioside GM1.	Gangliosides	330-341	N-acetyllactosaminide alpha-1,3-galactosyltransferase	Bos taurus	57-91
2412585-0	1985	Interaction of myelin basic protein with gangliosides and ganglioside-phospholipid mixtures.	Gangliosides	41-53	myelin basic protein	Homo sapiens	15-35
2412585-0	1985	Interaction of myelin basic protein with gangliosides and ganglioside-phospholipid mixtures.	Gangliosides	41-52	myelin basic protein	Homo sapiens	15-35
2411433-1	1985	Gangliosides were evaluated for their ability to inhibit the phenotype and function of an encephalitogenic T-helper lymphocyte line from Lewis rats (BP-1), which responds specifically to guinea pig myelin basic protein (GP-BP).	Gangliosides	0-12	Blood pressure QTL 1	Rattus norvegicus	149-153
2411433-1	1985	Gangliosides were evaluated for their ability to inhibit the phenotype and function of an encephalitogenic T-helper lymphocyte line from Lewis rats (BP-1), which responds specifically to guinea pig myelin basic protein (GP-BP).	Gangliosides	0-12	myelin basic protein	Cavia porcellus	198-218
2411433-3	1985	Incubation of activated BP-1 line cells with 250 microM gangliosides for 1 hr prior to injection prevented EAE completely in 5/14 recipients and markedly reduced the severity of clinical signs and histologic lesions in the rest.	Gangliosides	56-68	Blood pressure QTL 1	Rattus norvegicus	24-28
2411433-5	1985	Both individual and mixed gangliosides inhibited accessory cell-dependent activation of BP-1 cells with GP-BP.	Gangliosides	26-38	Blood pressure QTL 1	Rattus norvegicus	88-92
2411433-6	1985	Gangliosides also inhibited BP-1 activation with a cell-free supernatant containing accessory cell-processed GP-BP and rat Ia molecules, suggesting that the inhibition was not restricted to accessory cell function.	Gangliosides	0-12	Blood pressure QTL 1	Rattus norvegicus	28-32
2411433-7	1985	In addition to inhibiting antigen-dependent proliferation, gangliosides inhibited IL-2 dependent cell growth.	Gangliosides	59-71	interleukin 2	Rattus norvegicus	82-86
2411433-8	1985	Furthermore, individual and mixed gangliosides blocked binding of anti-T-helper cell antibody (W3/25) to the BP-1 line, while galactocerebroside, ceramide, and sialic acid had no inhibitory effect.	Gangliosides	34-46	Blood pressure QTL 1	Rattus norvegicus	109-113
3161732-11	1985	These results are significant in permitting the conclusion that the carbohydrate-specific binding of IFN-alpha and IFN-beta to gangliosides cannot be due to a similarity of the ganglioside carbohydrate to that of a glycoprotein containing a complex-type N-liked oligosaccharide.	Gangliosides	127-139	interferon alpha	Mus musculus	101-110
3161732-11	1985	These results are significant in permitting the conclusion that the carbohydrate-specific binding of IFN-alpha and IFN-beta to gangliosides cannot be due to a similarity of the ganglioside carbohydrate to that of a glycoprotein containing a complex-type N-liked oligosaccharide.	Gangliosides	127-139	interferon beta 1, fibroblast	Mus musculus	115-123
4030138-3	1985	In our study we could definitely prove this correlation: in fact the level of malignancy, passing from grade I to grade IV, is associated with a statistically significant increase of a ganglioside identified as ganglioside GD3.	Gangliosides	185-196	GRDX	Homo sapiens	223-226
4030138-3	1985	In our study we could definitely prove this correlation: in fact the level of malignancy, passing from grade I to grade IV, is associated with a statistically significant increase of a ganglioside identified as ganglioside GD3.	Gangliosides	211-222	GRDX	Homo sapiens	223-226
3930908-2	1985	Treatment of the lipids with graded neuraminidase and beta-galactosidase, gas chromatographic analysis of their carbohydrates, sphingosine bases and molecular species of sialic acid revealed that the structure of these gangliosides were GM3(NeuAc), GM3(NeuGc), GD3(NeuAc) and GD3(NeuGc), each of which was 16 +/- 2 micrograms, 304 +/- 42 micrograms, 30 +/- 3 micrograms and 240 +/- 26 micrograms, respectively, per gram of the dry erythrocyte stroma.	Gangliosides	219-231	neuraminidase 1	Homo sapiens	36-49
3930908-2	1985	Treatment of the lipids with graded neuraminidase and beta-galactosidase, gas chromatographic analysis of their carbohydrates, sphingosine bases and molecular species of sialic acid revealed that the structure of these gangliosides were GM3(NeuAc), GM3(NeuGc), GD3(NeuAc) and GD3(NeuGc), each of which was 16 +/- 2 micrograms, 304 +/- 42 micrograms, 30 +/- 3 micrograms and 240 +/- 26 micrograms, respectively, per gram of the dry erythrocyte stroma.	Gangliosides	219-231	galactosidase beta 1	Homo sapiens	54-72
3930908-2	1985	Treatment of the lipids with graded neuraminidase and beta-galactosidase, gas chromatographic analysis of their carbohydrates, sphingosine bases and molecular species of sialic acid revealed that the structure of these gangliosides were GM3(NeuAc), GM3(NeuGc), GD3(NeuAc) and GD3(NeuGc), each of which was 16 +/- 2 micrograms, 304 +/- 42 micrograms, 30 +/- 3 micrograms and 240 +/- 26 micrograms, respectively, per gram of the dry erythrocyte stroma.	Gangliosides	219-231	GRDX	Homo sapiens	261-264
3930908-2	1985	Treatment of the lipids with graded neuraminidase and beta-galactosidase, gas chromatographic analysis of their carbohydrates, sphingosine bases and molecular species of sialic acid revealed that the structure of these gangliosides were GM3(NeuAc), GM3(NeuGc), GD3(NeuAc) and GD3(NeuGc), each of which was 16 +/- 2 micrograms, 304 +/- 42 micrograms, 30 +/- 3 micrograms and 240 +/- 26 micrograms, respectively, per gram of the dry erythrocyte stroma.	Gangliosides	219-231	GRDX	Homo sapiens	276-279
3930908-3	1985	The amount of GM3 and GD3 accounted for more than 95% of total gangliosides of the erythrocytes.	Gangliosides	63-75	GRDX	Homo sapiens	22-25
3903474-0	1985	Ganglioside GD3: structure, cellular distribution, and possible function.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
3903474-2	1985	In this paper we review the structure of ganglioside GD3 and recent information on its cellular distribution.	Gangliosides	41-52	GRDX	Homo sapiens	53-56
3930908-4	1985	Porcine erythrocytes may provide a good source for large scale preparation of ganglioside GD3 which recently was identified as a human melanoma-associated antigen.	Gangliosides	78-89	GRDX	Homo sapiens	90-93
3930908-4	1985	Porcine erythrocytes may provide a good source for large scale preparation of ganglioside GD3 which recently was identified as a human melanoma-associated antigen.	Gangliosides	78-89	ankyrin repeat domain 36B	Homo sapiens	135-162
4064221-1	1985	The non-specific lipid transfer protein (nsL-TP) purified from rat and bovine liver accelerates the transfer of all common diacylglycerophospholipids, cholesterol as well as glycosphingolipids and gangliosides between membranes.	Gangliosides	197-209	sterol carrier protein 2	Rattus norvegicus	4-39
4072495-1	1985	In this work the possibility of using neuraminidase for increasing the content of ganglioside GM1 in the mixture of gangliosides used for the sensitization of erythrocytes has been studied.	Gangliosides	116-128	neuraminidase 1	Homo sapiens	38-51
4072495-2	1985	The study has revealed that the treatment of gangliosides with neuraminidase is sufficient for obtaining active hemosensitin; there is no need for the purification of the preparation by gel filtration.	Gangliosides	45-57	neuraminidase 1	Homo sapiens	63-76
4064221-1	1985	The non-specific lipid transfer protein (nsL-TP) purified from rat and bovine liver accelerates the transfer of all common diacylglycerophospholipids, cholesterol as well as glycosphingolipids and gangliosides between membranes.	Gangliosides	197-209	sterol carrier protein 2	Rattus norvegicus	41-47
3873347-2	1985	Because ganglioside GM1 is a component of the CT receptor, the present study was undertaken to determine whether gangliosides interact with CSF and therefore might play a role in the binding sites for CSF.	Gangliosides	8-19	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	201-204
4040555-0	1985	Gangliosides alter morphology and growth of astrocytes and increase the activity of choline acetyltransferase in cultures of dissociated septal cells.	Gangliosides	0-12	choline O-acetyltransferase	Rattus norvegicus	84-109
3873347-2	1985	Because ganglioside GM1 is a component of the CT receptor, the present study was undertaken to determine whether gangliosides interact with CSF and therefore might play a role in the binding sites for CSF.	Gangliosides	113-125	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	140-143
3873347-2	1985	Because ganglioside GM1 is a component of the CT receptor, the present study was undertaken to determine whether gangliosides interact with CSF and therefore might play a role in the binding sites for CSF.	Gangliosides	113-125	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	201-204
3873347-3	1985	Preincubation of CSF with increasing concentrations of bovine-brain mixed gangliosides resulted in decreased numbers of colonies of BM-derived granulocyte-macrophage progenitor cells (CFU-C) in soft agar.	Gangliosides	74-86	colony stimulating factor 2	Bos taurus	17-20
3873347-4	1985	The inhibitory effect of the gangliosides could be reduced by increasing the concentrations of CSF.	Gangliosides	29-41	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	95-98
3873347-5	1985	Evidence for direct binding of CSF to gangliosides was obtained by affinity chromatography of CSF on gangliosides-sepharose beads.	Gangliosides	38-50	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	31-34
3873347-5	1985	Evidence for direct binding of CSF to gangliosides was obtained by affinity chromatography of CSF on gangliosides-sepharose beads.	Gangliosides	38-50	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-97
3873347-5	1985	Evidence for direct binding of CSF to gangliosides was obtained by affinity chromatography of CSF on gangliosides-sepharose beads.	Gangliosides	101-113	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	31-34
4028024-5	1985	mAb R24 reacts with the disialoganglioside GD3, a predominant ganglioside on cultured melanoma cells and other cells of neuroectodermal origin.	Gangliosides	31-42	GRDX	Homo sapiens	43-46
3873347-5	1985	Evidence for direct binding of CSF to gangliosides was obtained by affinity chromatography of CSF on gangliosides-sepharose beads.	Gangliosides	101-113	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	94-97
3873347-7	1985	Four different individual gangliosides (GM1, GM2, GD1a, GT1b) were tested for their inhibitory effect on CSF-induced clonal growth of CFU-C. GM1 was the most effective with a 50% inhibition (I50) of clonal growth at a concentration of 15 microM.	Gangliosides	26-38	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	105-108
3873347-10	1985	These data indicate that GM1 interacts with CSF and suggest that gangliosides may play a role in the interaction of CSF with CFU-C and that the binding site for CSF on the surface of these cells might either consist of or contain this ganglioside.	Gangliosides	65-77	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	116-119
3873347-10	1985	These data indicate that GM1 interacts with CSF and suggest that gangliosides may play a role in the interaction of CSF with CFU-C and that the binding site for CSF on the surface of these cells might either consist of or contain this ganglioside.	Gangliosides	65-77	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	116-119
3873347-10	1985	These data indicate that GM1 interacts with CSF and suggest that gangliosides may play a role in the interaction of CSF with CFU-C and that the binding site for CSF on the surface of these cells might either consist of or contain this ganglioside.	Gangliosides	65-76	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	116-119
3873347-10	1985	These data indicate that GM1 interacts with CSF and suggest that gangliosides may play a role in the interaction of CSF with CFU-C and that the binding site for CSF on the surface of these cells might either consist of or contain this ganglioside.	Gangliosides	65-76	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	116-119
2986706-2	1985	The neutral glycosphingolipids and gangliosides which were isolated were characterized by thin-layer chromatography and neuraminidase treatment.	Gangliosides	35-47	neuraminidase 1	Homo sapiens	120-133
3873498-6	1985	Other melanoma-reactive MAb of the same isotype as Leo Me13 did not block killing of melanoma cells, but one documented antibody, R24, an IgG3 with specificity for the ganglioside GD3, was found to inhibit this function.	Gangliosides	168-179	GRDX	Homo sapiens	180-183
3998734-0	1985	Brain gangliosides of quaking and shiverer mutants: qualitative and quantitative changes of monosialogangliosides in the quaking brain.	Gangliosides	6-18	quaking, KH domain containing RNA binding	Mus musculus	22-29
3998734-1	1985	Ganglioside compositions in the brains of the mutant mice quaking and shiverer were compared with those of their littermate controls, C57BL/6 and C3HSWV.	Gangliosides	0-11	quaking, KH domain containing RNA binding	Mus musculus	58-65
3998734-3	1985	Change in the ganglioside composition of the mutant brain from that of the control was observed only in the quaking mutant brain, in which monosialoganglioside GM1 was significantly reduced and GM4 was completely absent.	Gangliosides	14-25	quaking, KH domain containing RNA binding	Mus musculus	108-115
3998734-3	1985	Change in the ganglioside composition of the mutant brain from that of the control was observed only in the quaking mutant brain, in which monosialoganglioside GM1 was significantly reduced and GM4 was completely absent.	Gangliosides	14-25	coenzyme Q10A	Mus musculus	160-163
3994380-5	1985	The major gangliosides in the polysialo fractions contained a ganglio-N-tetraose backbone and were identified as GD3, GD1a, GD1b, and GQ1b.	Gangliosides	10-22	GRDX	Homo sapiens	113-116
3997284-2	1985	The principal difference in the ganglioside profile between these two counterparts appears to be the presence of GD3 and the predominance of the less polar compounds (GM3, GM2, GM1) in CLL cells.	Gangliosides	32-43	GRDX	Homo sapiens	113-116
3882721-0	1985	Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells.	Gangliosides	12-23	fibronectin 1	Mus musculus	73-84
3986373-4	1985	It has been shown in model experiments with incorporation into the tumor cell membrane of brain ganglioside GD3 combined with thymic LacCer or with egg phosphatidylcholine that the increase in the sensitivity of the tumor cell membrane to spleen effectors is linked with a change in the properties of the lipid membrane matrix under the effect of unsaturated fatty acids (e.g. in experiments with phosphatidylcholine).	Gangliosides	96-107	GRDX	Homo sapiens	108-111
3882721-1	1985	Ganglioside-deficient transformed mouse fibroblasts (NCTC 2071A cells), which grow in serum-free medium, synthesize fibronectin but do not retain it on the cell surface.	Gangliosides	0-11	fibronectin 1	Mus musculus	116-127
3882721-0	1985	Fluorescent gangliosides as probes for the retention and organization of fibronectin by ganglioside-deficient mouse cells.	Gangliosides	12-24	fibronectin 1	Mus musculus	73-84
3882721-3	1985	When the cells were stained with anti-fibronectin antibodies and a fluorescent second antibody, fibrillar strands of fibronectin were observed to be attached to the cell surface, with partial coincidence of the patterns of direct ganglioside fluorescence and indirect fibronectin immunofluorescence at the cell surface.	Gangliosides	230-241	fibronectin 1	Mus musculus	117-128
3882721-3	1985	When the cells were stained with anti-fibronectin antibodies and a fluorescent second antibody, fibrillar strands of fibronectin were observed to be attached to the cell surface, with partial coincidence of the patterns of direct ganglioside fluorescence and indirect fibronectin immunofluorescence at the cell surface.	Gangliosides	230-241	fibronectin 1	Mus musculus	117-128
3882721-7	1985	When exogenous gangliosides were included in the incubation, there was a striking increase in cell-associated exogenous fibronectin, which was highly organized into a fibrillar network.	Gangliosides	15-27	fibronectin 1	Mus musculus	120-131
3882721-8	1985	Conversely, cells incubated for 18 h with exogenous unmodified gangliosides exhibited a highly organized network of endogenously derived fibronectin.	Gangliosides	63-75	fibronectin 1	Mus musculus	137-148
3882721-9	1985	Upon further incubation of the cells for 2 h with fluorescent gangliosides, there was considerable co-distribution of the fluorescent gangliosides with the fibronectin network as revealed by immunofluorescence.	Gangliosides	62-74	fibronectin 1	Mus musculus	156-167
3882721-9	1985	Upon further incubation of the cells for 2 h with fluorescent gangliosides, there was considerable co-distribution of the fluorescent gangliosides with the fibronectin network as revealed by immunofluorescence.	Gangliosides	134-146	fibronectin 1	Mus musculus	156-167
3882721-10	1985	Our results support the concept that gangliosides can mediate the attachment of fibronectin to the cell surface and its organization into a fibrillar network.	Gangliosides	37-49	fibronectin 1	Mus musculus	80-91
4009746-3	1985	These results indicate that abnormal ganglioside patterns do not result from the reeler mutation at early stages of brain development, and that the cell misalignment characteristic of the reeler phenotype involves molecules other than gangliosides.	Gangliosides	235-247	reelin	Mus musculus	188-194
3856264-13	1985	The agglutination of erythrocytes by fibronectin is also inhibited by gangliosides [Yamada, K.M., Kennedy, D.W., Grotendorst, G.R.	Gangliosides	70-82	fibronectin 1	Bos taurus	37-48
3856264-18	1985	Fibronectin, however, did not bind to sulfatides with high affinity but rather bound with low affinity to all anionic lipids tested, including phospholipids, gangliosides, and sulfatides.	Gangliosides	158-170	fibronectin 1	Bos taurus	0-11
3856277-0	1985	Strong antitumor activities of IgG3 antibodies to a human melanoma-associated ganglioside.	Gangliosides	78-89	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	31-35
3883355-1	1985	R24 is an IgG3 mouse monoclonal antibody that identifies GD3, a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin.	Gangliosides	74-85	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	10-14
3883355-1	1985	R24 is an IgG3 mouse monoclonal antibody that identifies GD3, a prominent ganglioside on the surface of melanoma cells and other cells of neuroectodermal origin.	Gangliosides	74-85	GRDX	Homo sapiens	57-60
4083391-1	1985	When compared with an age-matched normal control and a Duchenne muscular dystrophy (DMD) case, the patient with FCMD had an unusual ganglioside pattern in the cerebral gray matter.	Gangliosides	132-143	fukutin	Homo sapiens	112-116
4009746-0	1985	Ganglioside patterns during cerebral development in the normal and reeler mouse.	Gangliosides	0-11	reelin	Mus musculus	67-73
4009746-2	1985	The ganglioside pattern changed substantially as development proceeded in the telencephalon of both reeler and normal mice, but was the same at any given age for both conditions, despite the marked histological differences between reeler and normal samples.	Gangliosides	4-15	reelin	Mus musculus	100-106
4000396-2	1985	The results indicated that GM2 and GM3 were the principal gangliosides in the cells with only traces of GM1 and small amounts of disialogangliosides present.	Gangliosides	58-70	granulocyte macrophage antigen 3	Mus musculus	35-38
6488184-0	1984	Differential expression of ganglioside GD3 by human leukocytes and leukemia cells.	Gangliosides	27-38	GRDX	Homo sapiens	39-42
6394100-0	1984	Distribution of the ganglioside GD3 in the human nervous system detected by R24 mouse monoclonal antibody.	Gangliosides	20-31	GRDX	Homo sapiens	32-35
6488184-4	1984	A range of GD3 reactivity was apparent within the acute myeloid leukemia cells; gangliosides from pure myeloid leukemia cells stained more intensely than those from leukemia cells with monocytic characteristics.	Gangliosides	80-92	GRDX	Homo sapiens	11-14
6333283-0	1984	Inhibition of interleukin-2-dependent cytotoxic T-lymphocyte growth by gangliosides.	Gangliosides	71-83	interleukin 2	Bos taurus	14-27
6488184-6	1984	A ganglioside extract from the cells of a patient with hairy cell leukemia was also positive for GD3 immunostaining.	Gangliosides	2-13	GRDX	Homo sapiens	97-100
6488184-7	1984	These results demonstrate that normal leukocytes and chronic myelogenous leukemia cells are distinguished from other lymphoid and nonlymphoid leukemia cells on the basis of GD3 ganglioside expression.	Gangliosides	177-188	GRDX	Homo sapiens	173-176
6333283-2	1984	As one potential cellular site of this inhibition, the influence of gangliosides on interleukin-2-dependent T-cell proliferation was tested, using cultures of cytotoxic T cells (strain CT-6).	Gangliosides	68-80	interleukin 2	Bos taurus	84-97
6480822-2	1984	By immunodiffusion this cryoglobulin reacted (by its Fab" fragment) with micellar GM3, a ganglioside bearing the Pr2 antigenic determinant.	Gangliosides	89-100	FA complementation group B	Homo sapiens	53-56
6333283-8	1984	The results suggest that a primary mechanism whereby gangliosides inhibit lectin-induced lymphocyte mitogenesis is by inhibition of the interleukin-2-stimulated proliferation of T cells in these cultures.	Gangliosides	53-65	interleukin 2	Bos taurus	136-149
6096995-1	1984	The total fractions of gangliosides and cerebrosides isolated from the tissue of human brain were studied for their effect on the Na+, K+-ATPase activity of native erythrocytes and their membranes.	Gangliosides	23-35	dynein axonemal heavy chain 8	Homo sapiens	138-144
6096995-3	1984	Gangliosides inhibit the transport ATPase activity noncompetitively with respect to ATP and Na+ and competitively--to K+, cerebrosides inhibit it noncompetitively with respect to all ATPase activators.	Gangliosides	0-12	dynein axonemal heavy chain 8	Homo sapiens	35-41
6096995-3	1984	Gangliosides inhibit the transport ATPase activity noncompetitively with respect to ATP and Na+ and competitively--to K+, cerebrosides inhibit it noncompetitively with respect to all ATPase activators.	Gangliosides	0-12	dynein axonemal heavy chain 8	Homo sapiens	183-189
6481302-3	1984	The key findings are: (a) Asialo GM1, a major neutral glycolipid constituent of all macrophage populations examined, is accessible to galactose oxidase/NaB3H4 labeling on the surface of TG-elicited and BCG-activated macrophages but not on resident macrophages; (b) GM1 is the predominant ganglioside constituent of the mouse macrophage.	Gangliosides	288-299	coenzyme Q10A	Mus musculus	33-36
6470710-0	1984	Cellular distribution of gangliosides in the developing mouse cerebellum: analysis using the staggerer mutant.	Gangliosides	25-37	RAR-related orphan receptor alpha	Mus musculus	93-102
6386184-1	1984	It has been previously established in the guinea pig that the response of peritoneal macrophages to migration inhibitory factor (MIF) is enhanced by a macrophage glycolipid and that gangliosides reversibly bind MIF.	Gangliosides	182-194	macrophage migration inhibitory factor	Cavia porcellus	129-132
6386184-1	1984	It has been previously established in the guinea pig that the response of peritoneal macrophages to migration inhibitory factor (MIF) is enhanced by a macrophage glycolipid and that gangliosides reversibly bind MIF.	Gangliosides	182-194	macrophage migration inhibitory factor	Homo sapiens	211-214
6386184-10	1984	Coupling of bovine brain mixed gangliosides to agarose resulted in a matrix capable of reversibly binding MIF.	Gangliosides	31-43	macrophage migration inhibitory factor	Bos taurus	106-109
6520127-7	1984	Additional four gangliosides in the monosialoganglioside fraction were tentatively characterized as GM3(NeuAc), GM3(NeuGc), GM2(NeuGc), and sialosylneolactotetraosylceramide(NeuGc).	Gangliosides	16-28	granulocyte macrophage antigen 3	Mus musculus	100-103
6385004-1	1984	The predominant gangliosides produced by two cultured human melanoma cell lines are GD3 and/or GD2.	Gangliosides	16-28	GRDX	Homo sapiens	84-87
6385004-3	1984	Monoclonal antibodies directed to GD2 and GD3 specified the cell-surface distribution of these gangliosides and localized them in focal adhesion plaques at the interface of cells and their substratum.	Gangliosides	95-107	GRDX	Homo sapiens	42-45
6207945-0	1984	Interaction of myelin basic protein, melittin and bovine serum albumin with gangliosides, sulphatide and neutral glycosphingolipids in mixed monolayers.	Gangliosides	76-88	myelin basic protein	Homo sapiens	15-35
6477558-0	1984	The monoclonal antibody HNK-1 reacts with a human peripheral nerve ganglioside.	Gangliosides	67-78	beta-1,3-glucuronyltransferase 1	Homo sapiens	24-29
6477558-1	1984	The monoclonal HNK-1 antibody, a marker for human natural killer cells, strongly reacted with human peripheral nerve gangliosides in the enzyme-linked immunosorbent assay.	Gangliosides	117-129	beta-1,3-glucuronyltransferase 1	Homo sapiens	15-20
6477558-2	1984	Autoradiography after the binding of HNK-1 to thin-layer chromatograms of peripheral nerve gangliosides followed by radioiodinated goat anti-mouse IgM revealed that HNK-1 was reacting with a minor ganglioside that chromatographed between GM1 and GD1a.	Gangliosides	91-103	beta-1,3-glucuronyltransferase 1	Homo sapiens	165-170
6477558-2	1984	Autoradiography after the binding of HNK-1 to thin-layer chromatograms of peripheral nerve gangliosides followed by radioiodinated goat anti-mouse IgM revealed that HNK-1 was reacting with a minor ganglioside that chromatographed between GM1 and GD1a.	Gangliosides	91-102	beta-1,3-glucuronyltransferase 1	Homo sapiens	165-170
6087904-3	1984	(1) The monolayer experiments demonstrated an interaction with gangliosides GT1, GM1, dioleoylphosphatidic acid and phosphatidylserine, but little or no interaction with phosphatidylcholine or sphingomyelin.	Gangliosides	63-75	beta-1,4-galactosyltransferase 1	Homo sapiens	76-79
6087904-10	1984	It is suggested that ACTH-ganglioside interactions will participate in ACTH-receptor interactions.	Gangliosides	26-37	proopiomelanocortin	Homo sapiens	21-25
6087904-10	1984	It is suggested that ACTH-ganglioside interactions will participate in ACTH-receptor interactions.	Gangliosides	26-37	melanocortin 2 receptor	Homo sapiens	71-84
6378369-4	1984	All 3 gangliosides inhibited lymphocyte activation to a similar degree when tested over a concentration range of 5 to 100 micrograms per ml of culture.	Gangliosides	6-18	paired box 5	Homo sapiens	0-5
6378369-5	1984	Removal of sialic acid from the gangliosides by neuraminidase treatment significantly reduced or abolished their inhibitory effect.	Gangliosides	32-44	neuraminidase 1	Homo sapiens	48-61
6207945-0	1984	Interaction of myelin basic protein, melittin and bovine serum albumin with gangliosides, sulphatide and neutral glycosphingolipids in mixed monolayers.	Gangliosides	76-88	albumin	Homo sapiens	63-70
6430916-0	1984	Incorporation of fluorescent gangliosides into human fibroblasts: mobility, fate, and interaction with fibronectin.	Gangliosides	29-41	fibronectin 1	Homo sapiens	103-114
6430916-8	1984	Using antifibronectin antibodies and indirect immunofluorescence, these gangliosides were found to co-distribute with fibrillar fibronectin.	Gangliosides	72-84	fibronectin 1	Homo sapiens	10-21
6430916-9	1984	Thus, exogenous gangliosides appear to be stably inserted into the lipid bilayer of the plasma membrane and to diffuse freely in its plane as well as form a less mobile state with the fibrillar networks of fibronectin associated with the cells.	Gangliosides	16-28	fibronectin 1	Homo sapiens	206-217
6327695-16	1984	Thus, the level of gangliosides GM1 and GM3 in membranes may modulate PDGF receptor function by affecting the degree of tyrosine phosphorylation and may alter the affinity of the receptor for PDGF.	Gangliosides	19-31	coenzyme Q10A	Mus musculus	32-35
6238109-0	1984	Receptors for human alpha interferon: are gangliosides involved?	Gangliosides	42-54	interferon alpha 1	Homo sapiens	26-36
6238109-5	1984	Based on indirect evidence such as neutralization of the antiviral action of IFN preparations by gangliosides and binding of IFNs to gangliosides coupled to solid supports, it has been suggested by various investigators that gangliosides may be a part of the IFN-alpha/beta receptors.	Gangliosides	97-109	interferon alpha 1	Homo sapiens	77-80
6238109-6	1984	Experiments presented here indicate that gangliosides could block the antiviral activity of HuIFN-beta, but not of HuIFN-alpha, although both species of IFN bound strongly to gangliosides coupled to poly-L-lysine-agarose.	Gangliosides	41-53	interferon alpha 1	Homo sapiens	94-97
6238109-10	1984	The results indicate that at least in the case of HuIFN-alpha species, the ganglioside binding is apparently not at the active site of the IFN molecules required for interaction with the receptors on the cell surface.	Gangliosides	75-86	interferon alpha 1	Homo sapiens	52-55
6745256-2	1984	The general trend observed upon dilution of the cell suspension was a reduction of the less complex gangliosides GM3 and GM2 with concomitant increase of the more complex gangliosides, especially GM1.	Gangliosides	100-112	granulocyte macrophage antigen 3	Mus musculus	113-116
6432773-1	1984	GM2 containing NeuGc was a major ganglioside in the liver of mouse strains such as BALB/c, DBA/2, C3H/He, and C57BL/10, whereas WHT/Ht mouse liver did not contain GM2(NeuGc) but contained GM3(NeuGc) as a major ganglioside.	Gangliosides	33-44	cytochrome b5 domain containing 2	Mus musculus	0-3
6743805-1	1984	Gangliosides interact with human serum albumin, inducing conformational changes in its globule.	Gangliosides	0-12	albumin	Homo sapiens	33-46
6432773-1	1984	GM2 containing NeuGc was a major ganglioside in the liver of mouse strains such as BALB/c, DBA/2, C3H/He, and C57BL/10, whereas WHT/Ht mouse liver did not contain GM2(NeuGc) but contained GM3(NeuGc) as a major ganglioside.	Gangliosides	210-221	cytochrome b5 domain containing 2	Mus musculus	0-3
6609839-0	1984	Binding of interleukin 2 to gangliosides.	Gangliosides	28-40	interleukin 2	Homo sapiens	11-24
6609839-1	1984	Exogenous gangliosides inhibit interleukin 2 (IL2)-dependent growth of a T cell line, AKIL -1.E8.	Gangliosides	10-22	interleukin 2	Homo sapiens	31-44
6609839-1	1984	Exogenous gangliosides inhibit interleukin 2 (IL2)-dependent growth of a T cell line, AKIL -1.E8.	Gangliosides	10-22	interleukin 2	Homo sapiens	46-49
6609839-2	1984	IL2 activity is retained by columns of ganglioside covalently linked to poly(L-lysine)-agarose and is not eluted with ethylene glycol but is completely recovered by elution with 1% SDS.	Gangliosides	39-50	interleukin 2	Homo sapiens	0-3
6609839-3	1984	The ability of gangliosides to inhibit IL2 activity is directly related to the complexity of their carbohydrate portion, and related ceramide derivatives at similar concentrations do not inhibit IL2 activity.	Gangliosides	15-27	interleukin 2	Homo sapiens	39-42
6424717-2	1984	Cholesterol and alpha-tocopherol transfer from apolipoprotein A-I/1-palmityl-2- oleoylphosphatidylcholine ( POPC ) recombinants to bovine brain ganglioside/ POPC single bilage vesicles with half-times of approximately 20 min and 70 min, respectively.	Gangliosides	144-155	APOAI	Bos taurus	47-65
6609839-4	1984	We conclude that IL2 bound to exogenous gangliosides is inactive and that the carbohydrate portion of the ganglioside is crucial to its interaction with IL2.	Gangliosides	40-52	interleukin 2	Homo sapiens	17-20
6609839-4	1984	We conclude that IL2 bound to exogenous gangliosides is inactive and that the carbohydrate portion of the ganglioside is crucial to its interaction with IL2.	Gangliosides	40-51	interleukin 2	Homo sapiens	17-20
6200137-0	1984	Calorimetric studies on the interaction of gangliosides with phospholipids and myelin basic protein.	Gangliosides	43-55	myelin basic protein	Homo sapiens	79-99
6732768-3	1984	In human melanoma cells, grown in tissue culture, GD3 is the predominant ganglioside component (48-63% of total sialic acid).	Gangliosides	73-84	GRDX	Homo sapiens	50-53
6424662-1	1984	Competition and thermal inactivation experiments with different potential natural substrates indicated that in homogenates of human fibroblasts one single enzyme is acting on both (alpha 2-3) and (alpha 2-6) sialosyl linkages of oligosaccharides and glycoproteins, but not of the ganglioside GM3.	Gangliosides	280-291	immunoglobulin binding protein 1	Homo sapiens	197-206
6609724-2	1984	Incubation of splenocytes with gangliosides of the hemato-series (GM3 and GD3) or with their precursor, LacCer, decreases the cytotoxic NK-activity, whereas some other acidic and neutral glycolipids do not possess such capability.	Gangliosides	31-43	GRDX	Homo sapiens	74-77
6609724-4	1984	A comparison of the ganglioside profiles of two YAC call lines differing in their NK-sensitivity revealed the presence of a GD3-like component in the highly sensitive cell line and the absence of this ganglioside in low sensitive target cells.	Gangliosides	20-31	GRDX	Homo sapiens	124-127
6743700-0	1984	[Structure of lymphoma gangliosides in EL-4 mice].	Gangliosides	23-35	epilepsy 4	Mus musculus	39-43
6743700-1	1984	The structure of the major gangliosides from murine lymphoma EL-4 was established by acid hydrolysis, methanolysis, methylation analysis, neuraminidase treatment and chromium trioxide oxidation.	Gangliosides	27-39	epilepsy 4	Mus musculus	61-65
6743700-2	1984	Two of these gangliosides were identified as the N-acetyl and N-glycoloyl forms of the GM2 ganglioside.	Gangliosides	13-25	cytochrome b5 domain containing 2	Mus musculus	87-90
6608408-2	1984	The ganglioside showing elevated synthesis after mezerein or epidermal growth factor exposure is monosialoganglioside 1, whereas disialoganglioside 1b synthesis is elevated after phorbol ester exposure.	Gangliosides	4-15	epidermal growth factor	Mus musculus	61-84
6609724-5	1984	It is assumed that gangliosides of the hemato-series are components of the acceptor complex on the surface of the target cells and that shedding of these gangliosides (especially, of GD3) by tumour cells is one possible mechanism of NK-activity suppression during malignant growth.	Gangliosides	19-31	GRDX	Homo sapiens	183-186
6609724-5	1984	It is assumed that gangliosides of the hemato-series are components of the acceptor complex on the surface of the target cells and that shedding of these gangliosides (especially, of GD3) by tumour cells is one possible mechanism of NK-activity suppression during malignant growth.	Gangliosides	154-166	GRDX	Homo sapiens	183-186
6540046-4	1984	The first of these problems was approached by measuring sialic acid released (by the enzyme, neuraminidase) from gangliosides in lipid bilayers.	Gangliosides	113-125	neuraminidase 1	Homo sapiens	93-106
6362854-3	1984	The level of ganglioside GD3 was measured by quantitative absorption tests.	Gangliosides	13-24	GRDX	Homo sapiens	25-28
6362854-7	1984	Because ganglioside GD3 was detected in all 16 tissue specimens of primary and metastatic human malignant melanoma examined by immunofluorescence tests, the possible relevance of this finding in vivo is discussed.	Gangliosides	8-19	GRDX	Homo sapiens	20-23
6696440-9	1984	The ratio of N-acetyl- to N-glycolylneuraminic acid in dopamine beta-hydroxylase and the glycoproteins of chromaffin granule membranes is approximately 1.5:1, which is within the same range as that previously found in membrane gangliosides and in the chromogranins isolated from the soluble granule matrix.	Gangliosides	227-239	dopamine beta-hydroxylase	Bos taurus	55-80
6430047-2	1984	On the other hand, the liver of WHT/Ht, an inbred strain, contained GM3 (NeuGc) as a major ganglioside and lacked GM2 (NeuGc).	Gangliosides	91-102	granulocyte macrophage antigen 3	Mus musculus	68-71
6331133-1	1984	The thyrotropin (TSH) receptor has been proposed to be composed of a membrane glycoprotein and a membrane ganglioside, the former important in high affinity recognition, the latter vital for message coupling to the adenylate cyclase system.	Gangliosides	106-117	thyroid stimulating hormone receptor	Homo sapiens	4-30
6706920-2	1984	Most Japanese and a few Chinese wild mice have GM2(NeuGc) as a major ganglioside, whereas all wild mice caught at other places distributed all over the world other than Japan and China express GM1(NeuGc) and GD1a(NeuGc) in addition to GM2(NeuGC).	Gangliosides	69-80	cytochrome b5 domain containing 2	Mus musculus	47-57
6331133-7	1984	When this ganglioside is incorporated into 1-8 thyroid cells which have a correlated ganglioside deficiency and TSH receptor defect, reconstitution of TSH stimulated adenylate cyclase activity occurs.	Gangliosides	10-21	thyroid stimulating hormone receptor	Homo sapiens	112-124
6331133-10	1984	Implications of a TSH receptor structure in which its ganglioside and glycoprotein components are in equilibrium with pools of free components and, in turn, components important for cholera toxin, tetanus toxin and interferon receptors are discussed.	Gangliosides	54-65	thyroid stimulating hormone receptor	Homo sapiens	18-30
6331133-12	1984	Since antiidiotype studies of antibodies against TSH confirm a structural relationship between receptors for thyrotropin, cholera toxin, and thyroid stimulating autoantibodies, the data establish an unequivocal role for the ganglioside in TSH receptor structure which facilitates interpretation of in vitro experiments aimed at understanding the mechanism of ganglioside-ligand interactions.	Gangliosides	224-235	thyroid stimulating hormone receptor	Homo sapiens	239-251
6538394-2	1984	S pneumoniae neuraminidase exhibits optimum activity near neutral pH (6.0 to 6.5), and catalyzes the cleavage of sialic acid residues from glycoproteins, gangliosides and mucopolysaccharides.	Gangliosides	154-166	neuraminidase 1	Homo sapiens	13-26
6706920-3	1984	We recently reported that inbred strains of laboratory mice were also grouped into the same two types based on the ganglioside composition in the liver, and that the expression of GM1(NeuGc) and GD1a(NeuGc) was regulated by a gene located at the left outside the H-2 complex on chromosome 17 (Hashimoto, Y., Suzuki, A., Yamakawa, T., Miyashita, N., & Moriwaki, K. (1983) J. Biochem.	Gangliosides	115-126	coenzyme Q10A	Mus musculus	180-190
6706920-3	1984	We recently reported that inbred strains of laboratory mice were also grouped into the same two types based on the ganglioside composition in the liver, and that the expression of GM1(NeuGc) and GD1a(NeuGc) was regulated by a gene located at the left outside the H-2 complex on chromosome 17 (Hashimoto, Y., Suzuki, A., Yamakawa, T., Miyashita, N., & Moriwaki, K. (1983) J. Biochem.	Gangliosides	115-126	histocompatibility-2, MHC	Mus musculus	263-266
6671979-4	1983	This difference of the ganglioside composition between H-2 congenic and inbred-partner strains suggests that a gene for expression of GM1(NeuGc) and GD1a(NeuGc) is closely linked to the H-2 complex.	Gangliosides	23-34	histocompatibility-2, MHC	Mus musculus	55-58
6418214-9	1983	We conclude that the decreased ganglioside neuraminidase activities of mucopolysaccharidosis fibroblasts are due to an inhibition by the accumulated sulfated glycosaminoglycans and that such inhibition is responsible for the storage of certain gangliosides in the tissues of the patients.	Gangliosides	244-256	neuraminidase 1	Homo sapiens	43-56
6209415-1	1984	The interaction of the myelin basic protein (MBP) and the major endogenous ganglioside GM1 in myelin of the central nervous system has been investigated using both 500-MHz 1H and 67.89 MHz 13C NMR.	Gangliosides	75-86	myelin basic protein	Homo sapiens	45-48
6418214-2	1983	The neuraminidase activities towards the ganglioside substrates GD1a, GD3 and GM3 were found to be markedly diminished in homogenates of fibroblasts cultured from patients with various genetic mucopolysaccharidoses.	Gangliosides	41-52	neuraminidase 1	Homo sapiens	4-17
6418214-2	1983	The neuraminidase activities towards the ganglioside substrates GD1a, GD3 and GM3 were found to be markedly diminished in homogenates of fibroblasts cultured from patients with various genetic mucopolysaccharidoses.	Gangliosides	41-52	GRDX	Homo sapiens	70-73
6671979-4	1983	This difference of the ganglioside composition between H-2 congenic and inbred-partner strains suggests that a gene for expression of GM1(NeuGc) and GD1a(NeuGc) is closely linked to the H-2 complex.	Gangliosides	23-34	coenzyme Q10A	Mus musculus	134-144
6671979-4	1983	This difference of the ganglioside composition between H-2 congenic and inbred-partner strains suggests that a gene for expression of GM1(NeuGc) and GD1a(NeuGc) is closely linked to the H-2 complex.	Gangliosides	23-34	histocompatibility-2, MHC	Mus musculus	186-189
6615438-1	1983	Ganglioside GM1, 3H-labelled at the level of terminal galactose or of sphingosine, was intravenously injected into Swiss albino mice and some steps in its metabolic fate in the liver were investigated.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-15
6315058-10	1983	By use of the natural ganglioside [3H]GM3, the trypsin-resistant uptake was about 19 nmol/mg of cellular protein.	Gangliosides	22-33	granulocyte macrophage antigen 3	Mus musculus	38-41
6315058-11	1983	Although these amounts are quite similar, the uptake kinetics differed between the true ganglioside GM3 and the ganglioside analogues.	Gangliosides	88-99	granulocyte macrophage antigen 3	Mus musculus	100-103
6615438-2	1983	After administration of [3H]sphingosine-labelled GM1 all major liver gangliosides [GM3, GM2, GM1, GD1a-(NeuAc,NeuGl)] became radioactive, the radioactivity residing in all cases on the sphingosine moiety.	Gangliosides	69-81	coenzyme Q10A	Mus musculus	49-52
6615438-2	1983	After administration of [3H]sphingosine-labelled GM1 all major liver gangliosides [GM3, GM2, GM1, GD1a-(NeuAc,NeuGl)] became radioactive, the radioactivity residing in all cases on the sphingosine moiety.	Gangliosides	69-81	granulocyte macrophage antigen 3	Mus musculus	83-86
6615438-3	1983	The specific radioactivity was highest in GM1, which carried about 53% of the radioactivity incorporated into gangliosides, followed by GM2, with 34.5% of incorporated radioactivity, GM3 and GD1a-(NeuAc,NeuGl), both with about 5% of incorporated radioactivity.	Gangliosides	110-122	coenzyme Q10A	Mus musculus	42-45
6615438-4	1983	After administration of [3H]galactose-labelled GM1 the only radioactive gangliosides present in the liver were GM1 and GD1a-(NeuAc,NeuGl), the former carrying about 95% of the total ganglioside-incorporated radioactivity, the latter about 3%.	Gangliosides	72-84	coenzyme Q10A	Mus musculus	47-50
6615438-4	1983	After administration of [3H]galactose-labelled GM1 the only radioactive gangliosides present in the liver were GM1 and GD1a-(NeuAc,NeuGl), the former carrying about 95% of the total ganglioside-incorporated radioactivity, the latter about 3%.	Gangliosides	72-83	coenzyme Q10A	Mus musculus	47-50
6861145-0	1983	Shedding and immunoregulatory activity of YAC-1 lymphoma cell gangliosides.	Gangliosides	62-74	ADP-ribosyltransferase 1	Mus musculus	42-47
6615438-7	1983	All this suggests that exogenous GM1 may be involved in the metabolic routes of endogenous liver gangliosides.	Gangliosides	97-109	coenzyme Q10A	Mus musculus	33-36
6862694-6	1983	Compared with the NKS parental K562 tumor cells, the NKR butyrate-induced cells had 3.6- to 4.0-fold higher sialo-transferase activities and were associated with significantly greater amounts of cell surface sialic acid detected both in sialyl glycoproteins (2.2- to 2.9-fold higher) and particularly within ganglioside extracts (6.2- to 13.6-fold higher).	Gangliosides	308-319	killer cell lectin like receptor B1	Homo sapiens	53-56
6831431-2	1983	When mouse LM-22 cells (nonmalignant and devoid of gangliosides) were preincubated with GM1 ganglioside (3.0 micrograms/ml), the cell surface glycopeptide inhibitor effectively arrested cell division.	Gangliosides	51-63	coenzyme Q10A	Mus musculus	88-91
6225718-0	1983	Activating proteins for ganglioside GM2 degradation by beta-hexosaminidase isoenzymes in tissue extracts from different species.	Gangliosides	24-35	O-GlcNAcase	Homo sapiens	55-74
6225718-1	1983	The existence of activator proteins that stimulate hydrolysis of ganglioside GM2 by beta-hexosaminidase was demonstrated in kidney extracts from four species (rat, mouse, cattle and pig).	Gangliosides	65-76	O-GlcNAcase	Rattus norvegicus	84-103
6305420-4	1983	Gangliosides dispersed in such membranes were subjected to attack by the enzyme, neuraminidase, in order to assess their "accessibility".	Gangliosides	0-12	neuraminidase 1	Homo sapiens	81-94
6847688-4	1983	One of the fucose containing glycolipids forms globoside when treated with alpha-fucosidase, and one of the gangliosides forms globoside when treated with neuraminidase.	Gangliosides	108-120	neuraminidase 1	Homo sapiens	155-168
6619115-0	1983	GQ1b, a bioactive ganglioside that exhibits novel nerve growth factor (NGF)-like activities in the two neuroblastoma cell lines.	Gangliosides	18-29	nerve growth factor	Homo sapiens	50-69
6619115-0	1983	GQ1b, a bioactive ganglioside that exhibits novel nerve growth factor (NGF)-like activities in the two neuroblastoma cell lines.	Gangliosides	18-29	nerve growth factor	Homo sapiens	71-74
6619115-2	1983	We found that the total ganglioside fraction from human brain had two remarkable effects on these cell lines, which are similar to those of nerve growth factor (NGF): (a) an increase in the cell number, and (b) an increase in the neurite number and the total length of neurites.	Gangliosides	24-35	nerve growth factor	Homo sapiens	140-159
6619115-2	1983	We found that the total ganglioside fraction from human brain had two remarkable effects on these cell lines, which are similar to those of nerve growth factor (NGF): (a) an increase in the cell number, and (b) an increase in the neurite number and the total length of neurites.	Gangliosides	24-35	nerve growth factor	Homo sapiens	161-164
6619115-3	1983	In these cases, the genuine effector in total gangliosides could not be ascribed to a possibly contaminating NGF-like protein, but rather to a particular molecular species of the gangliosides, GQ1b, which could completely replace the effector function not only qualitatively but also quantitatively.	Gangliosides	46-58	nerve growth factor	Homo sapiens	109-112
6870892-0	1983	Human cancer-associated gangliosides defined by a monoclonal antibody (IB9) directed to sialosyl alpha 2 leads to 6 galactosyl residue: a preliminary note.	Gangliosides	24-36	proline rich protein BstNI subfamily 2	Homo sapiens	71-74
6853556-4	1983	Sugar analysis reveals that all 11 gangliosides contain the same base structure, Gal(beta 1-3)GalNAc(beta 1-4)Gal(beta 1-4)Glc(beta 1-1) ceramide, which is gangliotetraosylceramide.	Gangliosides	35-47	hemoglobin, beta adult major chain	Mus musculus	85-91
6853556-4	1983	Sugar analysis reveals that all 11 gangliosides contain the same base structure, Gal(beta 1-3)GalNAc(beta 1-4)Gal(beta 1-4)Glc(beta 1-1) ceramide, which is gangliotetraosylceramide.	Gangliosides	35-47	hemoglobin, beta adult major chain	Mus musculus	101-107
6853556-4	1983	Sugar analysis reveals that all 11 gangliosides contain the same base structure, Gal(beta 1-3)GalNAc(beta 1-4)Gal(beta 1-4)Glc(beta 1-1) ceramide, which is gangliotetraosylceramide.	Gangliosides	35-47	hemoglobin, beta adult major chain	Mus musculus	101-107
6853556-4	1983	Sugar analysis reveals that all 11 gangliosides contain the same base structure, Gal(beta 1-3)GalNAc(beta 1-4)Gal(beta 1-4)Glc(beta 1-1) ceramide, which is gangliotetraosylceramide.	Gangliosides	35-47	hemoglobin, beta adult major chain	Mus musculus	127-135
6870795-4	1983	The following major gangliosides were found to be present in mouse liver: GM3-NeuAc; GM3-NeuGl, GM2 [a mixture of one species carrying N-acetylneuraminic acid (NeuAc) and one carrying N-glycollylneuraminic acid (NeuGl)], GM1 and GD1a-(NeuAc,NeuGl).	Gangliosides	20-32	granulocyte macrophage antigen 3	Mus musculus	74-77
6833245-9	1983	Significant alterations were also observed in the complex carbohydrates of NGF-treated cells, the most striking of which were an almost 3-fold increase in labeled gangliosides and a 75% increase in trypsin-releasable glycoproteins.	Gangliosides	163-175	nerve growth factor	Rattus norvegicus	75-78
6191512-0	1983	Influence of cerebroside and ganglioside on the encephalitogenic activity of myelin basic protein in guinea pigs.	Gangliosides	29-40	myelin basic protein	Cavia porcellus	77-97
6191512-1	1983	The effect of 2 central nervous system glycolipids (cerebroside and ganglioside) on the encephalitogenic activity of bovine myelin basic protein (MBP) was studied in guinea pigs.	Gangliosides	68-79	myelin basic protein	Bos taurus	124-144
6191512-1	1983	The effect of 2 central nervous system glycolipids (cerebroside and ganglioside) on the encephalitogenic activity of bovine myelin basic protein (MBP) was studied in guinea pigs.	Gangliosides	68-79	myelin basic protein	Bos taurus	146-149
6132923-7	1983	The CTB moiety did, however, contribute to the biological activity of the conjugate, since the activity of the hybrid molecule, like cholera toxin, was inhibited by gangliosides, whereas the activity of native insulin was not.	Gangliosides	165-177	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	4-7
6132923-8	1983	Finally, the binding to thymocytes of insulin-CTB conjugate, but not insulin, was inhibited by gangliosides.	Gangliosides	95-107	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	46-49
6870795-4	1983	The following major gangliosides were found to be present in mouse liver: GM3-NeuAc; GM3-NeuGl, GM2 [a mixture of one species carrying N-acetylneuraminic acid (NeuAc) and one carrying N-glycollylneuraminic acid (NeuGl)], GM1 and GD1a-(NeuAc,NeuGl).	Gangliosides	20-32	granulocyte macrophage antigen 3	Mus musculus	85-88
6870795-4	1983	The following major gangliosides were found to be present in mouse liver: GM3-NeuAc; GM3-NeuGl, GM2 [a mixture of one species carrying N-acetylneuraminic acid (NeuAc) and one carrying N-glycollylneuraminic acid (NeuGl)], GM1 and GD1a-(NeuAc,NeuGl).	Gangliosides	20-32	cytochrome b5 domain containing 2	Mus musculus	96-99
6402368-5	1983	Chronic lymphocytic leukemia cell contained lesser amounts of three other gangliosides of the neolacto or lacto series as determined by endo-beta-galactosidase treatment.	Gangliosides	74-86	galactosidase beta 1	Homo sapiens	141-159
28305505-2	1983	Highest level of total ganglioside concentration was found in the layers of cortical anlage (cortical plate and "subplate layer") which are concomittantly characterized by highest activity of acetylcholinesterase (AChE) and which are known to be involved in intensive synaptogenesis at this stage of cortical development.	Gangliosides	23-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	192-212
28305505-2	1983	Highest level of total ganglioside concentration was found in the layers of cortical anlage (cortical plate and "subplate layer") which are concomittantly characterized by highest activity of acetylcholinesterase (AChE) and which are known to be involved in intensive synaptogenesis at this stage of cortical development.	Gangliosides	23-34	acetylcholinesterase (Cartwright blood group)	Homo sapiens	214-218
6832218-2	1983	These effects suggest a possible function of gangliosides as receptors for fibronectin.	Gangliosides	45-57	fibronectin 1	Mus musculus	75-86
6301462-2	1983	Reconstitution was achieved by exposing primary cell cultures of the tumor to preparations of gangliosides from thyroid cells with functional thyrotropin receptor activity.	Gangliosides	94-106	thyroid stimulating hormone receptor	Rattus norvegicus	142-162
6832218-3	1983	To test this hypothesis more directly, we examined the interaction of endogenous fibronectin with a ganglioside-deficient cell line, NCTC 2071.	Gangliosides	100-111	fibronectin 1	Mus musculus	81-92
6832218-0	1983	Exogenous gangliosides enhance the interaction of fibronectin with ganglioside-deficient cells.	Gangliosides	10-22	fibronectin 1	Mus musculus	50-61
6832218-6	1983	When the cells were cultured in medium containing ganglioside, the fibronectin became bound to the cell surface in fibrillar strands.	Gangliosides	50-61	fibronectin 1	Mus musculus	67-78
6832218-0	1983	Exogenous gangliosides enhance the interaction of fibronectin with ganglioside-deficient cells.	Gangliosides	10-21	fibronectin 1	Mus musculus	50-61
6832218-1	1983	The major cell-surface glycoprotein fibronectin mediates a variety of cellular adhesive interactions that have been reported to be competitively inhibited by gangliosides.	Gangliosides	158-170	fibronectin 1	Mus musculus	36-47
6832218-10	1983	Our results support the hypothesis that gangliosides can help mediate the binding of fibronectin to fibroblasts.	Gangliosides	40-52	fibronectin 1	Mus musculus	85-96
6298540-1	1983	The thyrotropin receptor is proposed to contain both a glycoprotein and a ganglioside component.	Gangliosides	74-85	thyroid stimulating hormone receptor	Homo sapiens	4-24
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	Gangliosides	42-53	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	80-83
6584083-2	1983	Chemically, the antigen was identified as ganglioside GD2 [Gal NAc beta 1----4 (Neu Ac alpha 2----8 Neu Ac alpha 2---3) Gal beta 1----4 Glc----ceramide].	Gangliosides	42-53	neuralized E3 ubiquitin protein ligase 1	Homo sapiens	100-103
7119793-3	1982	GM3 was the major ganglioside component of preconfluent S20Y cells, whereas GD1a was predominant in postconfluent cells.	Gangliosides	18-29	granulocyte macrophage antigen 3	Mus musculus	0-3
6192246-3	1983	Of the sialoglycosphingolipids (gangliosides) tested, only the myelin-specific monosialoganglioside, GM4, formed a precipitin line with myelin basic protein.	Gangliosides	32-44	myelin basic protein	Rattus norvegicus	136-156
6192246-6	1983	This finding, in concert with ganglioside-myelin basic protein complexes which selectively protect against neuraminidase, may provide a physiological explanation for the simplified ganglioside pattern found in myelin.	Gangliosides	30-41	myelin basic protein	Rattus norvegicus	42-62
6192246-6	1983	This finding, in concert with ganglioside-myelin basic protein complexes which selectively protect against neuraminidase, may provide a physiological explanation for the simplified ganglioside pattern found in myelin.	Gangliosides	181-192	myelin basic protein	Rattus norvegicus	42-62
7170057-0	1982	Modifications of ganglioside composition in peripheral nerve of myelin deficient Trembler mutant mouse.	Gangliosides	17-28	peripheral myelin protein 22	Mus musculus	81-89
6291959-0	1982	Gangliosides as receptors for fibronectin?	Gangliosides	0-12	fibronectin 1	Homo sapiens	30-41
6814359-2	1982	When 100 units/ml of IFN-beta were preincubated with 30-80 microM of the gangliosides, all antiviral activity was abolished.	Gangliosides	73-85	interferon beta 1	Homo sapiens	21-29
6189970-5	1983	In MS patients a positive correlation was seen between lymphocyte responses to myelin basic protein and to gangliosides.	Gangliosides	107-119	myelin basic protein	Homo sapiens	79-99
6812644-3	1982	This system has two advantages over previously published chromatography procedures: (i) it uses a commercially available column, and (ii) this single column can be used to analyze gangliosides and their neutral glycosphingolipid products generated by neuraminidase treatment.	Gangliosides	180-192	neuraminidase 1	Homo sapiens	251-264
6814359-6	1982	These results suggest that the terminal N-acetylneuraminic acid (NANA) residues of gangliosides and of glycophorin play an important role in the inhibition of IFN-beta, and that they may be similarly involved in the inhibition of IFN-gamma.	Gangliosides	83-95	interferon beta 1	Homo sapiens	159-167
6814359-6	1982	These results suggest that the terminal N-acetylneuraminic acid (NANA) residues of gangliosides and of glycophorin play an important role in the inhibition of IFN-beta, and that they may be similarly involved in the inhibition of IFN-gamma.	Gangliosides	83-95	interferon gamma	Homo sapiens	230-239
7121828-1	1982	We have studied the topography of the gangliosides of the adrenal chromaffin granules by using neuraminidase to remove sialic acid from membrane gangliosides of intact and ruptured chromaffin granules.	Gangliosides	145-157	neuraminidase 1	Bos taurus	95-108
7127155-4	1982	These ganglioside differences may thus be developmentally regulated, but the persistence into adulthood of higher levels of D1a in the dentate area suggests that some ganglioside pattern differences may be intrinsic to the unique neuronal cell populations present in different areas of the hippocampus.	Gangliosides	167-178	dopamine receptor D1	Rattus norvegicus	124-127
6813002-1	1982	Cultured skin fibroblasts from patients with mucolipidosis IV were found to be deficient in neuraminidase activity toward GD1a and GD1b gangliosides radiolabelled in C8 and C7 analogs of their sialic acid residues.	Gangliosides	136-148	neuraminidase 1	Homo sapiens	92-105
6813002-4	1982	The residual acidic neuraminidase activity toward GD1a ganglioside in the patients" fibroblasts did not differ from that of controls in its pH optimum and thermostability, but had an abnormal apparent Km which was about 18 times higher than that of the normal enzyme.	Gangliosides	55-66	neuraminidase 1	Homo sapiens	20-33
7052064-4	1982	(2) Ganglioside GM1 was specifically adsorbed from Nonidet P40 extracts of both surface- (galactose oxidase/NaB3H4 technique) and metabolically ([1-14C]palmitate) labelled cells in the presence of cholera toxin, anti-toxin and Staphylococcus aureus.	Gangliosides	4-15	coenzyme Q10A	Mus musculus	16-19
7118860-1	1982	The major gangliosides were isolated from small intestine of 2-week-old mice of C3H/He strain and identified as GM3, GM1, and GD1a.	Gangliosides	10-22	granulocyte macrophage antigen 3	Mus musculus	112-115
7118860-1	1982	The major gangliosides were isolated from small intestine of 2-week-old mice of C3H/He strain and identified as GM3, GM1, and GD1a.	Gangliosides	10-22	coenzyme Q10A	Mus musculus	117-120
7118860-4	1982	Gangliosides GM3, GM1, and GD1a contents increased in mouse small intestine during the suckling period, and decreased after weaning.	Gangliosides	0-12	granulocyte macrophage antigen 3	Mus musculus	13-16
7095839-2	1982	We reported previously that an anti-p cold agglutinin was inhibited by sialosyllactoneotetraosylceramide, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-Cer, the most abundant ganglioside of human erythrocytes.	Gangliosides	191-202	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	126-132
7095839-2	1982	We reported previously that an anti-p cold agglutinin was inhibited by sialosyllactoneotetraosylceramide, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-Cer, the most abundant ganglioside of human erythrocytes.	Gangliosides	191-202	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	142-150
7095839-2	1982	We reported previously that an anti-p cold agglutinin was inhibited by sialosyllactoneotetraosylceramide, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc-Cer, the most abundant ganglioside of human erythrocytes.	Gangliosides	191-202	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	142-148
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	Gangliosides	10-22	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	77-83
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	Gangliosides	10-22	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	93-101
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	Gangliosides	10-22	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	93-99
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	Gangliosides	10-22	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	122-130
7095839-4	1982	These two gangliosides have the same carbohydrate chain, NeuAc(alpha 2-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)GlcNAc(beta 1-3)Gal(beta 1-4)Glc(SNH), but they differ in their ceramide moiety.	Gangliosides	10-22	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	93-99
7052064-5	1982	(3) Ganglioside GM1 was the only ganglioside labelled when total cellular gangliosides separated on silica-gel sheets were overlayed with 125I-labelled cholera toxin, although GM3 and GD1a were the major gangliosides present.	Gangliosides	4-15	coenzyme Q10A	Mus musculus	16-19
7052064-5	1982	(3) Ganglioside GM1 was the only ganglioside labelled when total cellular gangliosides separated on silica-gel sheets were overlayed with 125I-labelled cholera toxin, although GM3 and GD1a were the major gangliosides present.	Gangliosides	33-44	coenzyme Q10A	Mus musculus	16-19
7052064-5	1982	(3) Ganglioside GM1 was the only ganglioside labelled when total cellular gangliosides separated on silica-gel sheets were overlayed with 125I-labelled cholera toxin, although GM3 and GD1a were the major gangliosides present.	Gangliosides	74-86	coenzyme Q10A	Mus musculus	16-19
7052064-5	1982	(3) Ganglioside GM1 was the only ganglioside labelled when total cellular gangliosides separated on silica-gel sheets were overlayed with 125I-labelled cholera toxin, although GM3 and GD1a were the major gangliosides present.	Gangliosides	204-216	coenzyme Q10A	Mus musculus	16-19
7061953-0	1982	GD3, a prominent ganglioside of human melanoma.	Gangliosides	17-28	GRDX	Homo sapiens	0-3
7110505-1	1982	Incubation of primary nerve cell cultures and of crude synaptosomal preparations with neuraminidase released sialic acid from both gangliosides and sialoglycoproteins.	Gangliosides	131-143	neuraminidase 1	Homo sapiens	86-99
7077353-4	1982	The ganglioside pattern and concentration in peripheral blood lymphocytes derived from MS patients and controls was identical with the predominant GM3, and small proportions of Gd3.	Gangliosides	4-15	GRDX	Homo sapiens	177-180
7068277-0	1982	A cell-surface antigen which is present in the ganglioside fraction and shared by human melanomas.	Gangliosides	47-58	CD53 molecule	Homo sapiens	2-22
7160447-0	1982	Ganglioside changes during cell aging in human diploid fibroblast TIG-1.	Gangliosides	0-11	retinoic acid receptor responder 1	Homo sapiens	66-71
6982604-3	1982	It was found that frog nervous tissues contained unique gangliosides which were easily hydrolyzed by neuraminidase and converted into asialo-GM1, suggesting the presence of new linkages of the sialic acids.	Gangliosides	56-68	neuraminidase 1	Homo sapiens	101-114
6211363-5	1982	TLC analysis of Florisil column-purified gangliosides from the sera of AKR/J and Swiss mice suggested presence of gangliosides with mobilities very close to GM2 and GM3 standards respectively.	Gangliosides	114-126	cytochrome b5 domain containing 2	Mus musculus	157-160
6211363-5	1982	TLC analysis of Florisil column-purified gangliosides from the sera of AKR/J and Swiss mice suggested presence of gangliosides with mobilities very close to GM2 and GM3 standards respectively.	Gangliosides	114-126	granulocyte macrophage antigen 3	Mus musculus	165-168
7078734-0	1982	The stimulating effect of ganglioside injections on the recovery of choline acetyltransferase and acetylcholinesterase activities in the hippocampus of the rat after septal lesions.	Gangliosides	26-37	choline O-acetyltransferase	Rattus norvegicus	68-93
7078734-0	1982	The stimulating effect of ganglioside injections on the recovery of choline acetyltransferase and acetylcholinesterase activities in the hippocampus of the rat after septal lesions.	Gangliosides	26-37	acetylcholinesterase	Rattus norvegicus	98-118
7078734-4	1982	The ratio of the enzyme activities from the animals injected with gangliosides to that from uninjected animals was 1.45 and 1.48 on the 18th day and 1.62 and 1.50 on the 50th day after the operation, for choline acetyltransferase and acetylcholinesterase activity, respectively.	Gangliosides	66-78	choline O-acetyltransferase	Rattus norvegicus	204-229
7078734-4	1982	The ratio of the enzyme activities from the animals injected with gangliosides to that from uninjected animals was 1.45 and 1.48 on the 18th day and 1.62 and 1.50 on the 50th day after the operation, for choline acetyltransferase and acetylcholinesterase activity, respectively.	Gangliosides	66-78	acetylcholinesterase	Rattus norvegicus	234-254
6175158-2	1982	In patients with multiple sclerosis (MS) there is not only an antibody-dependent lymphocyte cytotoxicity (ADLC) against basic protein of myelin (MBP), as was demonstrated earlier, but also against encephalitogenic peptide, cerebrosides and gangliosides.	Gangliosides	240-252	myelin basic protein	Homo sapiens	145-148
7160447-1	1982	Gangliosides of human diploid fibroblast, TIG-1, derived from fetal lung were analyzed during cell aging.	Gangliosides	0-12	retinoic acid receptor responder 1	Homo sapiens	42-47
7160447-2	1982	The major gangliosides of TIG-1 cells were GM3 and GD3.	Gangliosides	10-22	retinoic acid receptor responder 1	Homo sapiens	26-31
7317541-2	1981	GM2 was shown to be the main ganglioside in both tissues; however, the gangliosides of the hepatoma differed from liver gangliosides by a higher amount of disialoganglioside GD1a and by contents of monosialoganglioside GM1 and disialoganglioside GD1b which are absent in normal mouse liver.	Gangliosides	29-40	cytochrome b5 domain containing 2	Mus musculus	0-3
7334013-3	1981	The homogeneous ganglioside was subjected to graded neuraminidase treatment, mild acid hydrolysis, periodate oxidation-borohydride reduction, permethylation analysis and chromium trioxide oxidation.	Gangliosides	16-27	neuraminidase 1	Homo sapiens	52-65
6277554-0	1981	Effects of ganglioside therapy on experimental CS2 neuropathy.	Gangliosides	11-22	calsyntenin 2	Rattus norvegicus	47-50
6277554-2	1981	Since it was reported in several studies that the administration of gangliosides improves nerve regeneration and the functional recovery of nerves damaged by section as well as cryodegeneration, a study was undertaken to evaluate the effects of bovine-brain gangliosides administration on the experimental CS2 neuropathy in the rat.	Gangliosides	68-80	calsyntenin 2	Rattus norvegicus	306-309
7291999-3	1981	Ganglioside-supplemented media caused a twofold increase in ornithine decarboxylase activity in both culture systems.	Gangliosides	0-11	ornithine decarboxylase, structural 1	Mus musculus	60-83
6271797-2	1981	We find that purified solubilized gangliosides inhibit fibronectin-mediated hemagglutination, cell spreading, and restoration of a normal morphologic phenotype to transformed cells.	Gangliosides	34-46	fibronectin 1	Homo sapiens	55-66
6271797-3	1981	The inhibition is dose-dependent and competitive; hemagglutination by 2 micrograms/ml fibronectin is half-maximally inhibited by less than 1 microM gangliosides.	Gangliosides	148-160	fibronectin 1	Homo sapiens	86-97
6271797-8	1981	Our results support the hypothesis that the "receptors" for fibronectin on the cell surface either consist of or contain gangliosides or other negatively charged lipids.	Gangliosides	121-133	fibronectin 1	Homo sapiens	60-71
6971898-2	1981	Previously, asialo GM1 was considered the product of acid hydrolysis of the ganglioside GM1.	Gangliosides	76-87	coenzyme Q10A	Mus musculus	19-22
6170387-0	1981	Myelin basic protein interacts with the myelin-specific ganglioside GM4.	Gangliosides	56-67	myelin basic protein	Homo sapiens	0-20
6971898-2	1981	Previously, asialo GM1 was considered the product of acid hydrolysis of the ganglioside GM1.	Gangliosides	76-87	coenzyme Q10A	Mus musculus	88-91
6971898-3	1981	However, in the murine lymphoid system asialo GM1 is a normally occurring glycolipid that appears to be one of the intermediates in the biosynthesis between lactosylceramide and some recently described, terminally sialosylated gangliosides (for structures see Table I).	Gangliosides	227-239	coenzyme Q10A	Mus musculus	46-49
6894546-4	1981	All of the incorporated ganglioside ias accessible to neuraminidase, indicating that incorporation occurs only on the outer face of the bilayer.	Gangliosides	24-35	neuraminidase 1	Homo sapiens	54-67
6942682-5	1981	Findings suggest involvement of higher gangliosides in the attachment of cells to a fibronectin-collagen complex.	Gangliosides	39-51	fibronectin 1	Rattus norvegicus	84-95
6786889-2	1981	From eggs and embryos of the sea urchin Strongylocentrotus intermedius two gangliosides, provisionally named G-1 and G-2, were isolated in the pure state.	Gangliosides	75-87	myosin light chain, phosphorylatable, fast skeletal muscle	Rattus norvegicus	109-120
6942682-6	1981	Prior to metastasis, hepatoma lines become depleted in the putative fibronectin receptor gangliosides as an end result of a complex cascade of altered glycosyltransferase activities.	Gangliosides	89-101	fibronectin 1	Rattus norvegicus	68-79
6942682-8	1981	Analyses suggest that excess vitamin A may prevent the reappearance of fibronectin receptor gangliosides so that secondary tumor foci do not establish.	Gangliosides	92-104	fibronectin 1	Rattus norvegicus	71-82
6184818-4	1981	Furthermore, IFN can bind to gangliosides in a non-specific manner.	Gangliosides	29-41	interferon alpha 1	Homo sapiens	13-16
7451432-4	1981	The ganglioside was found to be resistant to neuraminidase (Clostridium perfringens), beta-hexosaminidase (jack bean), and beta-galactosidase.	Gangliosides	4-15	O-GlcNAcase	Homo sapiens	86-105
7014340-1	1981	Two main gangliosides (G-1 and G-2) were isolated from eggs and embryos S. intermedius.	Gangliosides	9-21	myosin regulatory light chain 2, skeletal muscle isoform type 2	Oryctolagus cuniculus	31-34
7014340-8	1981	Individual antigenic specificity of the gangliosides depends on the presence of N-glycolylneuraminic acid (G-1) and SO3H-group (G-2).	Gangliosides	40-52	myosin regulatory light chain 2, skeletal muscle isoform type 2	Oryctolagus cuniculus	128-131
7216169-9	1981	Among the different groups of naturally occurring NeuAc-containing substrates, i.e. glycoproteins, gangliosides and oligosaccharides, B. lactentis neuraminidase cleaves oligosaccharides preferentially without remarkable differences between (alpha 2 leads to 3) and (alpha 2 leads to 6) linkages.	Gangliosides	99-111	neuraminidase 1	Homo sapiens	147-160
6257300-0	1980	Action of ortho- and paramyxovirus neuraminidase on gangliosides.	Gangliosides	52-64	neuraminidase 1	Homo sapiens	35-48
7014713-11	1980	The data indicated that the number of cryptic GM1 and/or higher gangliosides exposed by neuraminidase in the cell membrane varied during cell differentiation and was directly related to specific cell types.	Gangliosides	64-76	neuraminidase 1	Homo sapiens	88-101
6257300-2	1980	The action of neuraminidase of influenza A virus, Sendai virus and Newcastle disease virus particles on bovine brain ganglioside GM1 and the properties of Sendai virus neuraminidase for GM1 were studied.	Gangliosides	117-128	neuraminidase 1	Homo sapiens	14-27
6257300-8	1980	In the absence of the surfactant, Sendai virus neuraminidase hydrolyzed GM1 more efficiently than Arthobacter ureafaciens neuraminidase which has been reported recently as being an adequate enzyme to hydrolyze ganglioside GM1 as a substrate.	Gangliosides	210-221	neuraminidase 1	Homo sapiens	47-60
6257300-8	1980	In the absence of the surfactant, Sendai virus neuraminidase hydrolyzed GM1 more efficiently than Arthobacter ureafaciens neuraminidase which has been reported recently as being an adequate enzyme to hydrolyze ganglioside GM1 as a substrate.	Gangliosides	210-221	neuraminidase 1	Homo sapiens	122-135
6257302-6	1980	Gangliosides GM2 and GM3 accumulated in the brain of the animals, and GM3 and asialo-GM2 were stored in the liver.	Gangliosides	0-12	cytochrome b5 domain containing 2	Mus musculus	13-16
6243648-3	1980	Gangliosides GM3 and GD1a constitute a majority of total cell gangliosides in both cell types, while ganglioside GM1, the putative choleragen receptor, constitutes less than 5%.	Gangliosides	0-12	granulocyte macrophage antigen 3	Mus musculus	13-16
7407217-1	1980	CMP-NAcNeu:GM3 ganglioside sialyltransferase (GD3 synthase) was characterized with respect to regulation of activity by nucleotides and compared in this regard with other sialyltransferases of ganglioside biosynthesis.	Gangliosides	15-26	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	46-58
7350145-0	1980	Inhibition of sialoglycosphingolipid (ganglioside) biosynthesis in mouse clonal lines N4TG1 and NG108-15 by beta-endorphin, enkephalins, and opiates.	Gangliosides	14-36	pro-opiomelanocortin-alpha	Mus musculus	108-122
6243648-4	1980	Differentiation results in a 75 to 85% decrease in ganglioside GM1.	Gangliosides	51-62	coenzyme Q10A	Mus musculus	63-66
7350145-0	1980	Inhibition of sialoglycosphingolipid (ganglioside) biosynthesis in mouse clonal lines N4TG1 and NG108-15 by beta-endorphin, enkephalins, and opiates.	Gangliosides	38-49	pro-opiomelanocortin-alpha	Mus musculus	108-122
7361617-0	1980	"Neuraminidase-resistant" sialic acid residues of gangliosides.	Gangliosides	50-62	neuraminidase 1	Homo sapiens	1-14
7376831-4	1980	Biochemical analysis of gangliosides in Con A and Hex A treated cells depicted a greater than 50% reduction in stored GM2 ganglioside and a fourfold reduction in GM2 label (14C) when compared to controls.	Gangliosides	24-36	hexosaminidase subunit alpha	Homo sapiens	50-55
6767344-0	1980	The specificity of beta-galactosidase in the degradation of gangliosides.	Gangliosides	60-72	galactosidase beta 1	Homo sapiens	19-37
7452229-4	1980	The most consistent and significant difference was the elevation of proportion of ganglioside GD3 from 4-5% of total LBSA in normal brain to 20% in the astrocytoma grade IV.	Gangliosides	82-93	GRDX	Homo sapiens	94-97
6159304-5	1980	OVA induced competitive effects were absorbed by anti-Thy-1 or anti-ganglioside.	Gangliosides	68-79	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	0-3
6159304-6	1980	Glycolipids could be extracted from the culture media supernatants of experimental and control groups as a ganglioside fraction containing Thy-1 determinants.	Gangliosides	107-118	thymus cell antigen 1, theta	Mus musculus	139-144
7448355-7	1980	The brain of affected animals showed substantial accumulation of the gangliosides GM3 and GM2.	Gangliosides	69-81	granulocyte macrophage antigen 3	Mus musculus	82-85
6108643-7	1980	On the contrary, an abnormal pattern of gangliosides was seen by densitometry of silica gel thin-layer plates with increases of GD3 and of an unknown ganglioside.	Gangliosides	40-52	GRDX	Homo sapiens	128-131
387601-0	1979	Use of ganglioside affinity filters to identify toxigenic strains of Clostridium botulinum types C and D. Clostridium botulinum neurotoxin is synthesized by toxic clones grown anaerobically on ganglioside affinity filters.	Gangliosides	7-18	neurotoxin	Clostridium botulinum	128-138
387601-0	1979	Use of ganglioside affinity filters to identify toxigenic strains of Clostridium botulinum types C and D. Clostridium botulinum neurotoxin is synthesized by toxic clones grown anaerobically on ganglioside affinity filters.	Gangliosides	193-204	neurotoxin	Clostridium botulinum	128-138
6778957-1	1980	Gangliosides GD3 and GM1 were coupled to proteins by their carboxyl groups and antisera were raised against the complexes.	Gangliosides	0-12	GRDX	Homo sapiens	13-16
500707-4	1979	The ganglioside preparations were subjected to mild acid hydrolysis, neuraminidase treatment, and periodate oxidation followed by borohydride reduction.	Gangliosides	4-15	neuraminidase 1	Homo sapiens	69-82
521447-4	1979	The main ganglioside is GM4 or sialosyl galactosyl ceramide in Type 1, and unidentified ganglioside in Type 2, GM4 and GM2 in almost equal amounts in Type 3, and GM2 in Type 4.	Gangliosides	9-20	T cell receptor alpha variable 6-3	Mus musculus	24-27
521447-4	1979	The main ganglioside is GM4 or sialosyl galactosyl ceramide in Type 1, and unidentified ganglioside in Type 2, GM4 and GM2 in almost equal amounts in Type 3, and GM2 in Type 4.	Gangliosides	9-20	T cell receptor alpha variable 6-3	Mus musculus	111-114
479110-2	1979	Mutations in this locus, called htx, result in the hypertoxinogenic phenotype, as measured by the ganglioside filter assay and immunoradial diffusion.	Gangliosides	98-109	Zic family member 3	Homo sapiens	32-35
6108643-7	1980	On the contrary, an abnormal pattern of gangliosides was seen by densitometry of silica gel thin-layer plates with increases of GD3 and of an unknown ganglioside.	Gangliosides	40-51	GRDX	Homo sapiens	128-131
100027-3	1978	The total amount of gangliosides in the duodenum of cat 1 was 100 times greater than in the duodenum of cat 2 per unit wet weight.	Gangliosides	20-32	GIT ArfGAP 1	Homo sapiens	52-57
226973-1	1979	Human beta-endorphin adopts a partial helical conformation in aqueous solutions of cerebroside sulfate, ganglioside GM1, phosphatidylserine, and phosphatidic acid, but not of cerebroside and phosphatidylcholine, as evidenced by circular dichroic spectra.	Gangliosides	104-115	proopiomelanocortin	Homo sapiens	6-20
114471-0	1979	[The complexing ability of gangliosides for Ca2, I.	Gangliosides	27-39	carbonic anhydrase 2	Gallus gallus	44-50
114471-2	1979	The binding of Ca2 to single ganglioside species (GGtet1NeuAc, GGtet2aNeuAc, GGtet 3aNeuAc), to their free, reducing sialyl-oligosaccharides and to ganglioside mixtures from chicken brain was investigated by means of ion-sensitive electrodes (potentiometry).	Gangliosides	29-40	carbonic anhydrase 2	Gallus gallus	15-18
114471-2	1979	The binding of Ca2 to single ganglioside species (GGtet1NeuAc, GGtet2aNeuAc, GGtet 3aNeuAc), to their free, reducing sialyl-oligosaccharides and to ganglioside mixtures from chicken brain was investigated by means of ion-sensitive electrodes (potentiometry).	Gangliosides	148-159	carbonic anhydrase 2	Gallus gallus	15-18
114471-3	1979	Unlike the sialyl-oligosaccharides and free N-acetylneuraminic acid, gangliosides were found to possess two different modes of binding for Ca2, depending on the total concentration of Ca2.	Gangliosides	69-81	carbonic anhydrase 2	Gallus gallus	139-142
114471-3	1979	Unlike the sialyl-oligosaccharides and free N-acetylneuraminic acid, gangliosides were found to possess two different modes of binding for Ca2, depending on the total concentration of Ca2.	Gangliosides	69-81	carbonic anhydrase 2	Gallus gallus	184-187
438198-5	1979	With glycoprotein and ganglioside acceptors this substrate specificity appears to be even more strict, with the sequence Gal/beta1 leads to 3GalNAc serving as the exclusive acceptor.	Gangliosides	22-33	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	125-130
311682-2	1979	Of four gangliosides tested, the trisialoganglioside, GT1, was the most potent inhibitor.	Gangliosides	8-20	retinoic acid induced 1	Mus musculus	54-57
454360-6	1979	The DBA strain, which is susceptible to audiogenic seizure at this age, had the highest level of the myelin-enriched ganglioside GM1 in all brain regions.	Gangliosides	117-128	coenzyme Q10A	Mus musculus	129-132
318456-4	1979	The ganglioside pattern of normothermic golden hamsters in comparison to that of mice is characterized by an unusual high amount of the polar trisialoganglioside GT1.	Gangliosides	4-15	retinoic acid induced 1	Mus musculus	162-165
291010-0	1979	Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen.	Gangliosides	0-11	fibronectin 1	Bos taurus	26-37
291010-2	1979	Bovine brain gangliosides were found to block fibronectin-mediated cell adhesion to collagen in a concentration-dependent manner.	Gangliosides	13-25	fibronectin 1	Bos taurus	46-57
291010-3	1979	The gangliosides did not block the binding of fibronectin to collagen but did prevent the attachment of the cells to the fibronectin-collagen complex.	Gangliosides	4-16	fibronectin 1	Bos taurus	121-132
291010-7	1979	These results suggest that specific gangliosides or related sialic acid-containing glycoconjugates on the cell surface may act as the receptors for fibronectin.	Gangliosides	36-48	fibronectin 1	Bos taurus	148-159
226345-6	1979	The toxin (1 microgram/ml)- (but not TSH-) induced increase in ODC was abolished by inclusion of ganglioside Ga and GT1 were without effect.	Gangliosides	97-108	ornithine decarboxylase 1	Rattus norvegicus	63-66
81194-1	1978	The aim of the present study was to determine the relationship of the Thy-1 antigenic determinants to the cell surface ganglioside GM1.	Gangliosides	119-130	thymus cell antigen 1, theta	Mus musculus	70-75
100027-3	1978	The total amount of gangliosides in the duodenum of cat 1 was 100 times greater than in the duodenum of cat 2 per unit wet weight.	Gangliosides	20-32	solute carrier family 7 member 2	Homo sapiens	104-109
99090-2	1978	Defective ganglioside and glycoprotein metabolism is due to deficient neuraminidase activity.	Gangliosides	10-21	neuraminidase 1	Homo sapiens	70-83
670832-6	1978	Additional ganglioside species, notably GD3, were also seen.	Gangliosides	11-22	GRDX	Homo sapiens	40-43
99263-4	1978	A novel ganglioside ALG1, which appears during the postnatal development of brain, has been isolated and purified; it  contains an alkali labile linkage and after alkaline treatment yields GT1b.	Gangliosides	8-19	asparagine-linked glycosylation 1 (beta-1,4-mannosyltransferase)	Mus musculus	20-24
683410-5	1978	Hg2+ inhibits synaptic membrane sialidase acting both in situ on the native sialocompounds in the membrane, or on exogenous ganglioside.	Gangliosides	124-135	neuraminidase 3	Bos taurus	23-41
658424-0	1978	Susceptibility of ganglioside GM1 to a new bacterial neuraminidase.	Gangliosides	18-29	neuraminidase 1	Homo sapiens	53-66
623779-7	1978	With this ganglioside-mapping technique, at least 25 unidentified gangliosides were separated from bovine and human brains in addition to the well-known compounds, G7, GM3, GM2, GM1, GM1 (GlycNeu), GD2, GD3, GD1a, GD1a-GAN, GD1a(AcNeu, GlycNeu), GD1b, GT1a, GT1b and GQ.	Gangliosides	10-21	GRDX	Homo sapiens	203-206
656602-3	1978	Neuraminidase-treated gangliosides were less effective.	Gangliosides	22-34	neuraminidase 1	Homo sapiens	0-13
24844-1	1978	Previous studies demonstrating that gangliosides interacted with thyrotropin and human chorionic gonadotropin (hCG) suggested that gangliosides participate in the transduction of the hormonal message across the target cell membrane.	Gangliosides	36-48	chorionic gonadotropin subunit beta 5	Homo sapiens	111-114
304463-1	1978	We have shown previously that purified antibodies to ganglioside GM1 react with peripheral T cells and most thymocytes in several strains of mice, independent of Thy-1 phenotype.	Gangliosides	53-64	coenzyme Q10A	Mus musculus	65-68
24844-1	1978	Previous studies demonstrating that gangliosides interacted with thyrotropin and human chorionic gonadotropin (hCG) suggested that gangliosides participate in the transduction of the hormonal message across the target cell membrane.	Gangliosides	131-143	chorionic gonadotropin subunit beta 5	Homo sapiens	111-114
24844-4	1978	Gangliosides extracted from the testes of control and treated animals were equally effective inhibitors of (125)I-hCG binding to testis membranes.	Gangliosides	0-12	chorionic gonadotropin subunit beta 5	Homo sapiens	114-117
24844-7	1978	Liposomes containing gangliosides from the testes of control or hCG-treated rats bound similar small amounts of (125)I-hCG.	Gangliosides	21-33	chorionic gonadotropin subunit beta 5	Homo sapiens	64-67
24844-7	1978	Liposomes containing gangliosides from the testes of control or hCG-treated rats bound similar small amounts of (125)I-hCG.	Gangliosides	21-33	chorionic gonadotropin subunit beta 5	Homo sapiens	119-122
665377-0	1978	Neuraminidase gangliosides interactions.	Gangliosides	14-26	neuraminidase 1	Homo sapiens	0-13
665379-5	1978	4) In vitro studies indicate that the activity of membrane-bound neuraminidase on gangliosides of brain membranes is regulated by the viscosity of these membranes and their monosialoganglioside content.	Gangliosides	82-94	neuraminidase 1	Bos taurus	65-78
590943-2	1977	The acylneuraminic acid residues, liberated from these gangliosides by treatment with dilute aqueous acid or neuraminidase, were analysed by the thin-layer chromatography and combined gas-liquid chromatography/mass spectrometry.	Gangliosides	55-67	neuraminidase 1	Homo sapiens	109-122
624111-3	1978	The saturation density increased about three-fold and the level of the simplest ganglioside GM3 (N-acetylneuraminylgalactosylglucosylceramide) increased about two-fold.	Gangliosides	80-91	granulocyte macrophage antigen 3	Mus musculus	92-95
272627-1	1978	The degradation of lipophilic ganglioside GD1a and hydrophilic sialyllactitol by membrane-bound neuraminidase (EC 3.2.1.18) from calf brain has been studied at substrate concentrations of 0.1 mM.	Gangliosides	30-41	neuraminidase 1	Bos taurus	96-109
272627-2	1978	Ganglioside GD1a taken up by cell membranes is hydrolyzed faster membrane-bound neuraminidase than are water-soluble substrates of the enzyme, sialyllactitol and des-GD1a.	Gangliosides	0-11	neuraminidase 1	Bos taurus	80-93
272627-7	1978	A model is presented that suggests that the activity of membrane-bound neuraminidase on gangliosides of brain membranes is regulated by the viscosity of these membranes and their monosialoganglioside content.	Gangliosides	88-100	neuraminidase 1	Bos taurus	71-84
893404-2	1977	By graded neuraminidase treatment, mild acid hydrolysis and periodate oxidation analysis, the ganglioside was identified as GT1a having the following structure: NeuAc(alpha, 2-8)NeuAc(alpha, 2-3)Gal(beta, 1-3)GalNAc(beta, 1-4) [NeuAc(alpha, 2-3)]Gal(beta, 1-4)Glc(1-1)ceramide.	Gangliosides	94-105	neuraminidase 1	Homo sapiens	10-23
411612-0	1977	GM1-ganglioside beta-galactosidase in leukocytes and cultured fibroblasts.	Gangliosides	4-15	galactosidase beta 1	Homo sapiens	16-34
28304867-3	1977	Thereafter the pattern changed little, but the concentration of all gangliosides present increased much more rapidly, especially between the 10th and 13th d.The postnatal cerebellum and olfactory lobes contained higher concentrations of GM1 and GM3 than the cortex, both gangliosides decreasing in favour of their di-, tri- and tetrasialo-homologues during the third postnatal week.In all brains structures the accretion of GD1a and GT1 was proportional to the increase in the activity of the acetylcholinesterase.Unlike the brain structures, the ganglioside pattern in the liver and spleen, characterised by a predominance of monosialogangliosides and of GD3, did not change noticeably during the first three weeks after birth.The coincidence of the changes in ganglioside accretion observed in the different brain structures with successive periods of morphological differentiation further support the suggestion that gangliosides may play an important role in control of the growth and differentiation of developing nerve cells.	Gangliosides	68-80	coenzyme Q10A	Mus musculus	237-240
71150-0	1977	Glucose release from liposomes containing gangliosides or other membrane lipids induced by biogenic amines and myelin basic protein.	Gangliosides	42-54	myelin basic protein	Homo sapiens	111-131
892714-5	1977	The binding of alkaloid to ganglioside structures is diminished in the presence of EDTA and after pretreatment with neuraminidase, suggesting a specific, Ca2 -dependent interaction of colchiceine with gangliosides.	Gangliosides	27-38	carbonic anhydrase 2	Rattus norvegicus	154-157
892714-5	1977	The binding of alkaloid to ganglioside structures is diminished in the presence of EDTA and after pretreatment with neuraminidase, suggesting a specific, Ca2 -dependent interaction of colchiceine with gangliosides.	Gangliosides	201-213	carbonic anhydrase 2	Rattus norvegicus	154-157
191002-0	1977	A ganglioside spin label: ganglioside head group interactions.	Gangliosides	2-13	spindlin 1	Homo sapiens	14-18
193492-0	1977	Separation of the glycoprotein and ganglioside components of thyrotropin receptor activity in plasma membranes.	Gangliosides	35-46	thyroid stimulating hormone receptor	Homo sapiens	61-81
191002-0	1977	A ganglioside spin label: ganglioside head group interactions.	Gangliosides	26-37	spindlin 1	Homo sapiens	14-18
1002698-6	1976	The third hexosamine-containing ganglioside belongs to a different series of glycolipids and was shown to have the structure of a major ganglioside of human brain: AcNeu(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[AcNeu(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer.	Gangliosides	136-147	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	183-190
320489-10	1977	Pre-treatment of the cells with neuraminidase or beta-galactosidase to alter the membrane gangliosides eliminates binding in growth cultures but not in differentiating cultures.	Gangliosides	90-102	galactosidase, beta 1	Mus musculus	49-67
844799-2	1977	The binding between cholera toxin or its B-protein subunit and various ganglioside-related oligosaccharides was studied by equilibrium displacement dialysis.	Gangliosides	71-82	tyrosinase related protein 1	Homo sapiens	41-50
1002698-6	1976	The third hexosamine-containing ganglioside belongs to a different series of glycolipids and was shown to have the structure of a major ganglioside of human brain: AcNeu(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[AcNeu(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer.	Gangliosides	32-43	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	239-246
1002698-6	1976	The third hexosamine-containing ganglioside belongs to a different series of glycolipids and was shown to have the structure of a major ganglioside of human brain: AcNeu(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[AcNeu(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer.	Gangliosides	32-43	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	183-190
1033935-8	1976	26, 723-732), and further support the concept that the pathway of synthesis of gangliosides proceeds via GM3 leads to GM2 leads to GM1.	Gangliosides	79-91	granulocyte macrophage antigen 3	Mus musculus	105-108
1002698-6	1976	The third hexosamine-containing ganglioside belongs to a different series of glycolipids and was shown to have the structure of a major ganglioside of human brain: AcNeu(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[AcNeu(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer.	Gangliosides	32-43	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	198-205
1002698-6	1976	The third hexosamine-containing ganglioside belongs to a different series of glycolipids and was shown to have the structure of a major ganglioside of human brain: AcNeu(alpha2-3)Gal(beta1-3)GalNAc(beta1-4)[AcNeu(alpha2-3)]Gal(beta1-4)Glc(beta1-1)Cer.	Gangliosides	32-43	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	227-234
1033935-8	1976	26, 723-732), and further support the concept that the pathway of synthesis of gangliosides proceeds via GM3 leads to GM2 leads to GM1.	Gangliosides	79-91	cytochrome b5 domain containing 2	Mus musculus	118-121
947892-4	1976	Following uptake of ganglioside GM1 (Gal-GalNAc-[AcNeu]-Gal-Glc-ceramide) from the medium, the cells respond to choleragen; however, they remain unresponsive following uptake of gangliosides GM2 (approximately 6 X 10(6) molecules/cell) and GM3 (AcNeu-Gal-Glc-ceramide) (approximately 2 X 10(6) molecules/cell).	Gangliosides	20-31	coenzyme Q10A	Mus musculus	32-35
186783-0	1976	Relationship of gangliosides to the structure and function of thyrotropin receptors: their absence on plasma membranes of a thyroid tumor defective in thyrotropin receptor activity.	Gangliosides	16-28	thyroid stimulating hormone receptor	Rattus norvegicus	62-82
1067617-5	1976	Our analyses of normal erythrocytes also revealed complex gangliosides with the approximate chromatographic mobilities of GD1b and GT1, and several gangliosides containing N-acetylglucosamine.	Gangliosides	58-70	beta-1,4-galactosyltransferase 1	Homo sapiens	131-134
826349-1	1976	The study of gangliosides as a function of age indicates that four of the main components GD1a (G3), GD1b (G2), GT1 (G1) and GQ (G0) are present at birth.	Gangliosides	13-25	retinoic acid induced 1	Mus musculus	112-115
947892-4	1976	Following uptake of ganglioside GM1 (Gal-GalNAc-[AcNeu]-Gal-Glc-ceramide) from the medium, the cells respond to choleragen; however, they remain unresponsive following uptake of gangliosides GM2 (approximately 6 X 10(6) molecules/cell) and GM3 (AcNeu-Gal-Glc-ceramide) (approximately 2 X 10(6) molecules/cell).	Gangliosides	20-31	cytochrome b5 domain containing 2	Mus musculus	191-194
947892-4	1976	Following uptake of ganglioside GM1 (Gal-GalNAc-[AcNeu]-Gal-Glc-ceramide) from the medium, the cells respond to choleragen; however, they remain unresponsive following uptake of gangliosides GM2 (approximately 6 X 10(6) molecules/cell) and GM3 (AcNeu-Gal-Glc-ceramide) (approximately 2 X 10(6) molecules/cell).	Gangliosides	20-31	granulocyte macrophage antigen 3	Mus musculus	240-243
947892-4	1976	Following uptake of ganglioside GM1 (Gal-GalNAc-[AcNeu]-Gal-Glc-ceramide) from the medium, the cells respond to choleragen; however, they remain unresponsive following uptake of gangliosides GM2 (approximately 6 X 10(6) molecules/cell) and GM3 (AcNeu-Gal-Glc-ceramide) (approximately 2 X 10(6) molecules/cell).	Gangliosides	178-190	coenzyme Q10A	Mus musculus	32-35
947892-9	1976	GM1, which becomes functionally integrated into the cells, appears to be the natural receptor for choleragen and is 50 to 1000 times more effective than other gangliosides in eliciting a choleragen response.	Gangliosides	159-171	coenzyme Q10A	Mus musculus	0-3
176657-6	1976	The possibility that a ganglioside or ganglioside-like structure is a component of the thyrotropin receptor is suggested by the finding that gangliosides more complex than N-acetylneuraminylgalactosylglucosylceramide are present in bovine thyroid membranes in much higher quantities than have been previously found in extraneural tissue.	Gangliosides	23-34	thyroid stimulating hormone receptor	Bos taurus	87-107
176657-6	1976	The possibility that a ganglioside or ganglioside-like structure is a component of the thyrotropin receptor is suggested by the finding that gangliosides more complex than N-acetylneuraminylgalactosylglucosylceramide are present in bovine thyroid membranes in much higher quantities than have been previously found in extraneural tissue.	Gangliosides	38-49	thyroid stimulating hormone receptor	Bos taurus	87-107
176657-6	1976	The possibility that a ganglioside or ganglioside-like structure is a component of the thyrotropin receptor is suggested by the finding that gangliosides more complex than N-acetylneuraminylgalactosylglucosylceramide are present in bovine thyroid membranes in much higher quantities than have been previously found in extraneural tissue.	Gangliosides	141-153	thyroid stimulating hormone receptor	Bos taurus	87-107
1062221-5	1976	Both gangliosides isolated were hydrolysed by neuraminidase.	Gangliosides	5-17	neuraminidase 1	Homo sapiens	46-59
1097530-5	1975	The kinetics of GM1 numbers when the ganglioside was added even as late as the 4th day of culture.	Gangliosides	37-48	coenzyme Q10A	Mus musculus	16-19
937144-1	1976	From cell fractionation studies it is concluded that gangliosides have a wide distribution in neuronal plasma membranes, being concentrated in the microsomal and the nerve-ending membranes rich in acetylcholinesterase.	Gangliosides	53-65	acetylcholinesterase (Cartwright blood group)	Homo sapiens	197-217
165898-3	1975	At slightly higher (but nontoxic) concentrations, the ionophore inhibits the butyrate-mediated induction of the ganglioside biosynthetic enzyme, sialyltransferase, in HeLa.	Gangliosides	112-123	ST6 beta-galactoside alpha-2,6-sialyltransferase 2	Homo sapiens	145-162
1155067-6	1975	The porportion of the minor gangliosides with short carbohydrate chains was increased because the reduction affected mainly the four major brain gangliosides GM1, GD1a, GD1b and GT1.	Gangliosides	28-40	myosin light chain 4	Homo sapiens	178-181
1234668-1	1975	The turnover rate of N-acetylneuraminic acid of brain gangliosides (GT1, GD1b, GD1a, GM1) was studied following the injection of 2-14C-acetate.	Gangliosides	54-66	beta-1,4-galactosyltransferase 1	Homo sapiens	68-71
804170-6	1975	Beta-Galactosidase from the patient had a Km that was higher then normal; 5-fold higher with ganglioside GM1 and 2-fold higher with 4-methylumbelliferyl beta-galactoside.	Gangliosides	93-104	galactosidase beta 1	Homo sapiens	0-18
4352518-0	1973	Availability to neuraminidase of gangliosides and sialoglycoproteins in neuronal membranes.	Gangliosides	33-45	neuraminidase 1	Homo sapiens	16-29
4530298-2	1974	TAL/N cells of early passage, which contain large quantities of gangliosides G(M3), G(M2), G(M1), and G(Dla), as well as the glycosyltransferases necessary for the synthesis of these gangliosides, bind the most cholera toxin and are the most sensitive to its action.	Gangliosides	64-76	talipes	Mus musculus	0-3
5080324-0	1972	The enzymic synthesis of gangliosides: uridine diphosphate galactose: N-acetylgalactosaminyl-(N-acetylneuraminyl)-galactosyl-glucosyl-ceramide galactosyltransferase in rat tissues.	Gangliosides	25-37	glycoprotein alpha-galactosyltransferase 1	Rattus norvegicus	143-164
4339464-0	1972	Ganglioside biosynthesis in mouse cells: glycosyltransferase activities in normal and virally-transformed lines.	Gangliosides	0-11	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	41-60
5418476-3	1970	Radioactive gangliosides were isolated and selectively degraded with bacterial neuraminidase and rat liver beta-galactosidase to Tay-Sachs ganglioside-(3)H. Radioactivity in the labeled product was confined to the N-acetyl-neuraminic acid portion of the molecule.	Gangliosides	12-24	galactosidase, beta 1	Rattus norvegicus	107-125
5060344-0	1972	[Gangliosides of the nerve endings in rabbit brain in normal conditions and during poisoning with organophosphorus cholinesterase inhibitors].	Gangliosides	1-13	cholinesterase	Oryctolagus cuniculus	115-129
5053445-0	1972	-Ketosidic linkage of the neuraminidase-resistent neuraminic acid in brain gangliosides.	Gangliosides	75-87	neuraminidase 1	Homo sapiens	26-39
5418476-3	1970	Radioactive gangliosides were isolated and selectively degraded with bacterial neuraminidase and rat liver beta-galactosidase to Tay-Sachs ganglioside-(3)H. Radioactivity in the labeled product was confined to the N-acetyl-neuraminic acid portion of the molecule.	Gangliosides	12-23	galactosidase, beta 1	Rattus norvegicus	107-125
5646187-1	1968	A ganglioside, previously designated HG-B in our laboratory, was isolated from mixed human brain ganglioside preparations and shown to contain equimolar quantities of sialic acid, galactose, and sphingosine.	Gangliosides	2-13	cytoglobin	Homo sapiens	37-41
5380013-0	1969	The effect of nerve growth factor (NGF) on the synthesis of gangliosides.	Gangliosides	60-72	nerve growth factor	Homo sapiens	14-33
5380013-0	1969	The effect of nerve growth factor (NGF) on the synthesis of gangliosides.	Gangliosides	60-72	nerve growth factor	Homo sapiens	35-38
5646187-1	1968	A ganglioside, previously designated HG-B in our laboratory, was isolated from mixed human brain ganglioside preparations and shown to contain equimolar quantities of sialic acid, galactose, and sphingosine.	Gangliosides	97-108	cytoglobin	Homo sapiens	37-41
4968773-0	1967	[On a reaction of lysozyme with gangliosides].	Gangliosides	32-44	lysozyme	Homo sapiens	18-26
4302220-0	1968	[On a component of the mixture of brain gangliosides, which is transferred to the Tay-Sachs ganglioside under the influence of neuraminidase].	Gangliosides	40-52	neuraminidase 1	Homo sapiens	127-140
33933428-1	2021	Ganglioside GM3 in the plasma membranes suppresses cell growth by preventing the autophosphorylation of the epidermal growth factor receptor (EGFR).	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	108-140
4380024-0	1966	The effect of thiols and ganglioside on the alterations in water, sodium and potassium distribution produced in brain slices by vasopressin and protamine.	Gangliosides	25-36	arginine vasopressin	Homo sapiens	128-139
6029825-2	1967	Neuraminidase prepared from Vibrio cholerae was added to a substrate containing ganglioside, prepared from calf brain.	Gangliosides	80-91	neuraminidase 1	Bos taurus	0-13
33933428-1	2021	Ganglioside GM3 in the plasma membranes suppresses cell growth by preventing the autophosphorylation of the epidermal growth factor receptor (EGFR).	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	142-146
33909305-10	2021	The postulation of four possible neuroplastin environments pointed to the GD1a ganglioside enrichment during reproductive senescence of stressed females, as well as its high dispersion in both regions and to GD1a and GM1 loss in the CA1 region.	Gangliosides	79-90	neuroplastin	Rattus norvegicus	33-45
33909065-9	2021	On the other hand, a most recent study indicates that gangliosides could serve as ligands for receptor-binding domain (RBD) of SARS-CoV-2 spike protein.	Gangliosides	54-66	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	138-143
33367717-2	2021	beta-1,4-N-acetyl galactosaminyltransferase 1 (B4GALNT1), which is involved in the synthesis of complex gangliosides, is highly expressed in the progression of various cancers.	Gangliosides	104-116	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	0-45
33367717-2	2021	beta-1,4-N-acetyl galactosaminyltransferase 1 (B4GALNT1), which is involved in the synthesis of complex gangliosides, is highly expressed in the progression of various cancers.	Gangliosides	104-116	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	47-55
33896187-11	2021	It appears that the immunosuppressive effect of gangliosides, presumably via the CD22 signaling pathway, is limited only to anti-PEG immunity.	Gangliosides	48-60	CD22 antigen	Mus musculus	81-85
33864399-3	2021	Disrupting GalNAc-transferase (GalNAc-T), thus eliminating all a- and b-series complex gangliosides (with consequent over-expression of GM3 and GD3) leads to an age-dependent neurodegeneration.	Gangliosides	87-99	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	11-29
33896625-5	2021	The MFGM gained much interest as a potential nutraceutical, due to their high phospholipid (PL), ganglioside (GD), and protein contents.	Gangliosides	97-108	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	4-8
33864399-3	2021	Disrupting GalNAc-transferase (GalNAc-T), thus eliminating all a- and b-series complex gangliosides (with consequent over-expression of GM3 and GD3) leads to an age-dependent neurodegeneration.	Gangliosides	87-99	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	31-39
33864399-6	2021	Previously, we have shown that reintroduction of both a- and b-series gangliosides into neurons on a global GalNAcT -/- background is sufficient to rescue this age-dependent neurodegenerative phenotype.	Gangliosides	70-82	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	108-115
33864399-9	2021	We found that this neuronal reconstitution of a-series complex gangliosides abrogated the adult lethal phenotype in Dbl KO mice, and partially attenuated the neurodegenerative features.	Gangliosides	63-75	mcf.2 transforming sequence	Mus musculus	116-119
33859643-0	2021	Ganglioside GD3 May Suppress the Functional Activities of Benign Skin T Cells in Cutaneous T-Cell Lymphoma.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
33493613-3	2021	Here, we evaluated liposomes containing the CD169/Siglec-1 binding ligand, ganglioside GM3, and the non-binding ligand, ganglioside GM1, for their capacity to target antigens to CD169+ macrophages and to induce immune responses.	Gangliosides	75-86	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	178-183
33407998-0	2021	Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients.	Gangliosides	0-11	hyaluronan synthase 2	Homo sapiens	27-53
33359145-2	2021	Membrane components such as cholesterol and gangliosides not only enhance the production of amyloidogenic Abeta fragments, but also appear to strengthen Abeta-membrane interaction.	Gangliosides	44-56	amyloid beta precursor protein	Rattus norvegicus	106-111
33359145-2	2021	Membrane components such as cholesterol and gangliosides not only enhance the production of amyloidogenic Abeta fragments, but also appear to strengthen Abeta-membrane interaction.	Gangliosides	44-56	amyloid beta precursor protein	Rattus norvegicus	153-158
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Gangliosides	163-175	angiotensin converting enzyme 2	Homo sapiens	55-86
33614627-5	2020	The main receptor for SARS-CoV-2 is represented by the angiotensin-converting enzyme-2 (ACE-2), although it also binds to sialic acids linked to host cell surface gangliosides.	Gangliosides	163-175	angiotensin converting enzyme 2	Homo sapiens	88-93
33614627-6	2020	A new type of ganglioside-binding domain within the N-terminal portion of the SARS-CoV-2 spike protein was identified.	Gangliosides	14-25	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	89-94
33407998-0	2021	Ganglioside GT1b increases hyaluronic acid synthase 2 via PI3K activation with TLR2 dependence in orbital fibroblasts from thyroid eye disease patients.	Gangliosides	0-11	toll like receptor 2	Homo sapiens	79-83
33300910-5	2021	Mechanistically, we indicated that BPIS significantly impairs the expression of a gene encoding multidrug resistance protein 1 (MDR1), a well-known permeability glycoprotein (P-gp), by preventing ganglioside GM3 catabolism.	Gangliosides	196-207	ATP binding cassette subfamily B member 1	Homo sapiens	96-126
33518565-0	2021	A Case of Sporadic Amyotrophic Lateral Sclerosis Due to a FUS P525L Mutation with Asymmetric Muscle Weakness and Anti-ganglioside Antibodie.	Gangliosides	118-129	FUS RNA binding protein	Homo sapiens	58-61
33296186-5	2021	Ganglioside-MAG interactions are often studied in cellular or animal models where their relative concentrations are not easily controlled or in assays where the gangliosides and MAG are not presented as part of fluid lipid bilayers.	Gangliosides	0-11	myelin associated glycoprotein	Homo sapiens	12-15
33296186-5	2021	Ganglioside-MAG interactions are often studied in cellular or animal models where their relative concentrations are not easily controlled or in assays where the gangliosides and MAG are not presented as part of fluid lipid bilayers.	Gangliosides	0-11	myelin associated glycoprotein	Homo sapiens	178-181
33296186-5	2021	Ganglioside-MAG interactions are often studied in cellular or animal models where their relative concentrations are not easily controlled or in assays where the gangliosides and MAG are not presented as part of fluid lipid bilayers.	Gangliosides	161-173	myelin associated glycoprotein	Homo sapiens	12-15
33296186-6	2021	Here, we present an approach to characterize MAG-ganglioside interactions in real time, where MAG, GD1a, and GT1b contents are controlled and they are in their in vivo orientation within fluid lipid bilayers.	Gangliosides	49-60	myelin associated glycoprotein	Homo sapiens	45-48
33296186-6	2021	Here, we present an approach to characterize MAG-ganglioside interactions in real time, where MAG, GD1a, and GT1b contents are controlled and they are in their in vivo orientation within fluid lipid bilayers.	Gangliosides	49-60	myelin associated glycoprotein	Homo sapiens	94-97
33296186-9	2021	We further demonstrate how MAG-ganglioside interactions can be disrupted by antiganglioside antibodies that override MAG-based neuron growth inhibition.	Gangliosides	31-42	myelin associated glycoprotein	Homo sapiens	27-30
33296186-9	2021	We further demonstrate how MAG-ganglioside interactions can be disrupted by antiganglioside antibodies that override MAG-based neuron growth inhibition.	Gangliosides	31-42	myelin associated glycoprotein	Homo sapiens	117-120
33300910-6	2021	Neuraminidase 3 (NEU3) is a key enzyme catalyzing the conversion of ganglioside GM3 to ceramide trihexosides (Gb3), whose expression is increased in drug-resistant HCT-116/L cells.	Gangliosides	68-79	neuraminidase 3	Homo sapiens	0-15
33300910-6	2021	Neuraminidase 3 (NEU3) is a key enzyme catalyzing the conversion of ganglioside GM3 to ceramide trihexosides (Gb3), whose expression is increased in drug-resistant HCT-116/L cells.	Gangliosides	68-79	neuraminidase 3	Homo sapiens	17-21
33300910-6	2021	Neuraminidase 3 (NEU3) is a key enzyme catalyzing the conversion of ganglioside GM3 to ceramide trihexosides (Gb3), whose expression is increased in drug-resistant HCT-116/L cells.	Gangliosides	68-79	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	110-113
33300910-5	2021	Mechanistically, we indicated that BPIS significantly impairs the expression of a gene encoding multidrug resistance protein 1 (MDR1), a well-known permeability glycoprotein (P-gp), by preventing ganglioside GM3 catabolism.	Gangliosides	196-207	ATP binding cassette subfamily B member 1	Homo sapiens	128-132
33300910-8	2021	These findings reveal that BPIS increases the chemo-sensitivity by remodeling NEU3-mediated ganglioside GM3 catabolism, and it may be applied as a novel drug for facilitating the effectiveness of chemotherapeutic agents in CRC.	Gangliosides	92-103	neuraminidase 3	Homo sapiens	78-82
33396723-1	2020	Sandhoff disease (SD) is a lysosomal disease caused by mutations in the gene coding for the beta subunit of beta-hexosaminidase, leading to deficiency in the enzymes beta-hexosaminidase (HEX) A and B. SD is characterised by an accumulation of gangliosides and related glycolipids, mainly in the central nervous system, and progressive neurodegeneration.	Gangliosides	243-255	O-GlcNAcase	Mus musculus	108-127
33223341-0	2021	A Guillain-Barre syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.	Gangliosides	86-98	sialic acid binding Ig like lectin 10	Homo sapiens	37-45
33223341-7	2021	Recombinant Siglec-10 protein containing R47Q but not A108V shows impaired binding to gangliosides.	Gangliosides	86-98	sialic acid binding Ig like lectin 10	Homo sapiens	12-21
33223341-10	2021	Because Siglec-10 regulates antibody production to sialylated antigens, our finding suggests that Siglec-10 regulates development of GBS by suppressing antibody production to gangliosides, with defects in its function predisposing to disease.	Gangliosides	175-187	sialic acid binding Ig like lectin 10	Homo sapiens	8-17
33223341-10	2021	Because Siglec-10 regulates antibody production to sialylated antigens, our finding suggests that Siglec-10 regulates development of GBS by suppressing antibody production to gangliosides, with defects in its function predisposing to disease.	Gangliosides	175-187	sialic acid binding Ig like lectin 10	Homo sapiens	98-107
32951428-0	2020	Development of fluorescent ganglioside GD3 and GQ1b analogs for elucidation of raft-associated interactions.	Gangliosides	27-38	GRDX	Homo sapiens	39-42
32951428-4	2020	The chemical synthesis of fluorescent GD3 and GQ1b was achieved using sialylation and ganglioside synthetic methods developed by our group previously.	Gangliosides	86-97	GRDX	Homo sapiens	38-41
33478937-5	2021	The expression of ABCA13 induced the internalization of cholesterol and gangliosides from the plasma membrane to intracellular vesicles.	Gangliosides	72-84	ATP-binding cassette, sub-family A (ABC1), member 13	Mus musculus	18-24
33255564-4	2020	In this study, we incorporated a physiological ligand for CD169, the ganglioside GM3, into liposomes to enhance liposome uptake by CD169+ macrophages.	Gangliosides	69-80	sialic acid binding Ig like lectin 1	Homo sapiens	58-63
32861756-0	2020	Tumor hypoxia regulates ganglioside GM3 synthase, which contributes to oxidative stress resistance in malignant melanoma.	Gangliosides	24-35	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	36-48
32861756-6	2020	Results Hypoxia treatment decreased the expression of ganglioside GM3 synthase (GM3S; ST3GAL5), which synthesizes the common substrate of ganglioside biosynthesis.	Gangliosides	54-65	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	80-84
32861756-6	2020	Results Hypoxia treatment decreased the expression of ganglioside GM3 synthase (GM3S; ST3GAL5), which synthesizes the common substrate of ganglioside biosynthesis.	Gangliosides	54-65	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	86-93
33259552-6	2020	While both Sandhoff cats and Tay-Sachs sheep accumulated significant amounts of GM2 and GA2 gangliosides compared to age-matched unaffected controls, the Sandhoff cats having the more severe disease, accumulated larger amounts of gangliosides compared to Tay-Sachs sheep in their occipital lobes.	Gangliosides	92-104	electron transfer flavoprotein subunit alpha	Homo sapiens	88-91
33255564-4	2020	In this study, we incorporated a physiological ligand for CD169, the ganglioside GM3, into liposomes to enhance liposome uptake by CD169+ macrophages.	Gangliosides	69-80	sialic acid binding Ig like lectin 1	Homo sapiens	131-136
32853705-4	2020	Gangliosides represent an emerging class, being used as tumor markers and targets of antibody therapy in melanomas, based on their elevated abundance in melanoma, especially of GM3 and GD3, when compared with the corresponding normal tissues.	Gangliosides	0-12	GRDX	Homo sapiens	185-188
33000220-0	2020	Gangliosides and CD82 inhibit the motility of colon cancer by downregulating the phosphorylation of EGFR at different tyrosine sites and signaling pathways.	Gangliosides	0-12	epidermal growth factor receptor	Homo sapiens	100-104
33000220-1	2020	Previous studies have shown that (GM3), a ganglioside, suppresses hepatoma cell motility and migration by inhibiting phosphorylation of EGFR and the activity of the PI3K/AKT signaling pathway.	Gangliosides	42-53	epidermal growth factor receptor	Homo sapiens	136-140
33000220-1	2020	Previous studies have shown that (GM3), a ganglioside, suppresses hepatoma cell motility and migration by inhibiting phosphorylation of EGFR and the activity of the PI3K/AKT signaling pathway.	Gangliosides	42-53	AKT serine/threonine kinase 1	Homo sapiens	170-173
33000220-2	2020	Therefore, the aim of the present study was to investigate whether the combined treatment of CD82 with gangliosides can exert a synergistic inhibitory effect on cell motility and migration.	Gangliosides	103-115	CD82 molecule	Homo sapiens	93-97
33000220-3	2020	Epidermal growth factor receptor (EGFR) signaling was studied for its role in the mechanism through which CD82 and gangliosides synergistically inhibit the motility and migration of SW620 human colon adenocarcinoma cells.	Gangliosides	115-127	epidermal growth factor receptor	Homo sapiens	0-32
33000220-3	2020	Epidermal growth factor receptor (EGFR) signaling was studied for its role in the mechanism through which CD82 and gangliosides synergistically inhibit the motility and migration of SW620 human colon adenocarcinoma cells.	Gangliosides	115-127	epidermal growth factor receptor	Homo sapiens	34-38
33067394-0	2020	Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes.	Gangliosides	88-99	sialic acid binding Ig like lectin 1	Homo sapiens	50-55
33067394-2	2020	Here, we describe a liposomal vaccine carrier that delivers tumor antigens to human CD169/Siglec-1+ antigen-presenting cells using gangliosides as targeting ligands.	Gangliosides	131-143	sialic acid binding Ig like lectin 1	Homo sapiens	84-89
33067394-2	2020	Here, we describe a liposomal vaccine carrier that delivers tumor antigens to human CD169/Siglec-1+ antigen-presenting cells using gangliosides as targeting ligands.	Gangliosides	131-143	sialic acid binding Ig like lectin 1	Homo sapiens	90-98
33067394-3	2020	Ganglioside-liposomes specifically bound to CD169 and were internalized by in vitro-generated monocyte-derived DCs (moDCs) and macrophages and by ex vivo-isolated splenic macrophages in a CD169-dependent manner.	Gangliosides	0-11	sialic acid binding Ig like lectin 1	Homo sapiens	44-49
33067394-3	2020	Ganglioside-liposomes specifically bound to CD169 and were internalized by in vitro-generated monocyte-derived DCs (moDCs) and macrophages and by ex vivo-isolated splenic macrophages in a CD169-dependent manner.	Gangliosides	0-11	sialic acid binding Ig like lectin 1	Homo sapiens	188-193
33067394-4	2020	In blood, high-dimensional reduction analysis revealed that ganglioside-liposomes specifically targeted CD14+ CD169+ monocytes and Axl+ CD169+ DCs.	Gangliosides	60-71	sialic acid binding Ig like lectin 1	Homo sapiens	110-115
33067394-4	2020	In blood, high-dimensional reduction analysis revealed that ganglioside-liposomes specifically targeted CD14+ CD169+ monocytes and Axl+ CD169+ DCs.	Gangliosides	60-71	AXL receptor tyrosine kinase	Homo sapiens	131-134
33067394-4	2020	In blood, high-dimensional reduction analysis revealed that ganglioside-liposomes specifically targeted CD14+ CD169+ monocytes and Axl+ CD169+ DCs.	Gangliosides	60-71	sialic acid binding Ig like lectin 1	Homo sapiens	136-141
33067394-6	2020	Finally, Axl+ CD169+ DCs were present in cancer patients and efficiently captured ganglioside-liposomes.	Gangliosides	82-93	AXL receptor tyrosine kinase	Homo sapiens	9-12
33067394-6	2020	Finally, Axl+ CD169+ DCs were present in cancer patients and efficiently captured ganglioside-liposomes.	Gangliosides	82-93	sialic acid binding Ig like lectin 1	Homo sapiens	14-19
33284868-7	2020	The average intake of gangliosides for lactating mothers was 6.33 mg/day, of which GM3 was 3.02 mg/day and GD3 was 1.51 mg/day.	Gangliosides	22-34	GRDX	Homo sapiens	107-110
32889026-9	2020	Furthermore, the THc protein was found to recognise and bind to ganglioside GT1b in a dose-dependent manner, and anti-THc sera antibodies also inhibited binding between THc and GT1b.	Gangliosides	64-75	WASP actin nucleation promoting factor	Homo sapiens	17-20
32961778-3	2020	Of the hundreds of unique GSL structures, anionic gangliosides are the most heavily implicated in the pathogenesis of lysosomal storage diseases (LSDs) such as Tay-Sachs and Sandhoff disease.	Gangliosides	50-62	cathepsin A	Homo sapiens	26-29
32562764-3	2020	Furthermore, it is emphasized that the viral spike protein is prevented from binding gangliosides, which are composed of a glycosphingolipid with one or more sialic acids, in the presence of chloroquine or hydroxychloroquine.	Gangliosides	85-97	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	45-50
32958938-6	2020	Harnessing this resource, we used genome-lipid association data as an additional aid to identify a number of lipids, for example gangliosides through their association with B4galnt1, and found evidence for a group of sex-specific phosphatidylcholines through their shared locus.	Gangliosides	129-141	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	173-181
31395948-6	2020	Moreover, transgenic T cells exhibited the downregulation of GM3 synthase, a key enzyme involved in the biosynthesis of gangliosides.	Gangliosides	120-132	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	61-73
33003399-0	2020	Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-kappaB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells.	Gangliosides	6-17	HPS1, biogenesis of lysosomal organelles complex 3 subunit 1	Mus musculus	0-5
33003399-0	2020	Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-kappaB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells.	Gangliosides	6-17	myeloid differentiation primary response gene 88	Mus musculus	69-74
33003399-0	2020	Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-kappaB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells.	Gangliosides	6-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	85-94
33003399-0	2020	Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-kappaB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells.	Gangliosides	6-17	mitogen-activated protein kinase 8	Mus musculus	99-102
33003399-0	2020	Hp-s1 Ganglioside Suppresses Proinflammatory Responses by Inhibiting MyD88-Dependent NF-kappaB and JNK/p38 MAPK Pathways in Lipopolysaccharide-Stimulated Microglial Cells.	Gangliosides	6-17	mitogen-activated protein kinase 14	Mus musculus	103-111
33003399-1	2020	Hp-s1 ganglioside is isolated from the sperm of sea urchin (Hemicentrotus pulcherrimus).	Gangliosides	6-17	HPS1, biogenesis of lysosomal organelles complex 3 subunit 1	Mus musculus	0-5
32253672-1	2020	BACKGROUND: beta-1,4-N-Acetyl-galactosaminyltransferase 4 (B4GALNT4), an enzyme involved in ganglioside synthesis, is upregulated in many cancers.	Gangliosides	92-103	beta-1,4-N-acetyl-galactosaminyltransferase 4	Homo sapiens	12-57
32869836-6	2020	In this context, complex sphingolipids, such as ganglioside GM3, have been shown to be directly involved in TGF-b receptor 1 (TGF-R1) activation.	Gangliosides	48-59	transforming growth factor beta receptor 1	Homo sapiens	108-124
32869836-6	2020	In this context, complex sphingolipids, such as ganglioside GM3, have been shown to be directly involved in TGF-b receptor 1 (TGF-R1) activation.	Gangliosides	48-59	transforming growth factor beta receptor 1	Homo sapiens	126-132
32916822-7	2020	GM1 has been shown to induce specific changes in the spatial organization of Abeta, which lead to enhanced peptide accumulation and deleterious effect especially on neuronal membranes containing clusters of this ganglioside.	Gangliosides	212-223	amyloid beta precursor protein	Homo sapiens	77-82
32253672-1	2020	BACKGROUND: beta-1,4-N-Acetyl-galactosaminyltransferase 4 (B4GALNT4), an enzyme involved in ganglioside synthesis, is upregulated in many cancers.	Gangliosides	92-103	beta-1,4-N-acetyl-galactosaminyltransferase 4	Homo sapiens	59-67
32451473-6	2020	Here, we describe a genome-wide forward screen that shows that glucosylceramide synthase and other components of the ganglioside synthetic pathway are crucial host factors that are required for cellular entry by hepatoviruses.	Gangliosides	117-128	UDP-glucose ceramide glucosyltransferase	Homo sapiens	63-88
32062833-5	2020	In these microdomains LRP6 is strictly associated with ganglioside GM1, a paradigmatic component of these plasma membrane compartments, as revealed by coimmunoprecipitation experiments.	Gangliosides	55-66	LDL receptor related protein 6	Homo sapiens	22-26
32149357-4	2020	Murine islets express predominantly sialylated GSLs, particularly the simple gangliosides GM3 and GD3 having a potential modulatory role in Glut2 activity.	Gangliosides	77-89	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	140-145
32149357-11	2020	We conclude that in particular the negatively charged gangliosides GM3 and GD3 of beta cells positively influence Glut2 function to adequately respond to high glucose loads.	Gangliosides	54-66	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	114-119
32762772-1	2020	Sandhoff disease (SD) is a lysosomal storage disease, caused by loss of beta-hexosaminidase (HEX) activity resulting in the accumulation of ganglioside GM2.	Gangliosides	140-151	O-GlcNAcase	Mus musculus	72-91
32142821-2	2020	Accumulating evidence, both in vivo and in vitro, suggests that the binding of Abeta to gangliosides, especially monosialoganglioside GM1, plays an important role in the aggregation of Abeta.	Gangliosides	88-100	amyloid beta precursor protein	Homo sapiens	79-84
32142821-2	2020	Accumulating evidence, both in vivo and in vitro, suggests that the binding of Abeta to gangliosides, especially monosialoganglioside GM1, plays an important role in the aggregation of Abeta.	Gangliosides	88-100	amyloid beta precursor protein	Homo sapiens	185-190
32142821-3	2020	This review summarizes the molecular details of the binding of Abeta to ganglioside-containing membranes and subsequent structural changes, as revealed by liposomal and cellular studies.	Gangliosides	72-83	amyloid beta precursor protein	Homo sapiens	63-68
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	Gangliosides	13-25	leptin receptor	Mus musculus	53-68
32862840-6	2020	Due to this mimicry, ATM interacts with the ganglioside-binding domain of SARS-CoV-2 spike protein.	Gangliosides	44-55	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	85-90
32358995-0	2020	Upregulation of Cell Surface GD3 Ganglioside Phenotype is Associated with Human Melanoma Brain Metastasis.	Gangliosides	33-44	GRDX	Homo sapiens	29-32
32358995-3	2020	We found ganglioside GD3 levels significantly upregulated in MBM compared to lymph node metastasis (LNM) but not for other melanoma gangliosides.	Gangliosides	9-20	GRDX	Homo sapiens	21-24
32567070-9	2020	Moreover, lipid rafts and especially gangliosides play a critical role in the formation and toxicity of Abeta oligomers.	Gangliosides	37-49	amyloid beta precursor protein	Homo sapiens	104-109
32751790-4	2020	CTB binds specifically and with high affinity to exosomal GM1 ganglioside residing in rafts only, and it has long been the probe of choice for membrane rafts.	Gangliosides	62-73	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-3
32405156-6	2020	Due to this mimicry, ATM interacts with the ganglioside-binding domain of SARS-CoV-2 spike protein.	Gangliosides	44-55	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	85-90
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	Gangliosides	13-25	leptin receptor	Mus musculus	70-74
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	Gangliosides	13-25	leptin receptor	Mus musculus	88-92
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	Gangliosides	13-25	Janus kinase 2	Mus musculus	129-133
32731387-4	2020	The a-series gangliosides GM1 and GD1a interact with leptin receptor (LepR) and promote LepR signaling through activation of the JAK2/STAT3 pathway.	Gangliosides	13-25	signal transducer and activator of transcription 3	Mus musculus	134-139
32731387-5	2020	Studies of GM3S KO cells have shown that the extracellular signal-regulated kinase (ERK) pathway, downstream of the LepR signaling pathway, is also modulated by gangliosides.	Gangliosides	161-173	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	11-15
32731387-5	2020	Studies of GM3S KO cells have shown that the extracellular signal-regulated kinase (ERK) pathway, downstream of the LepR signaling pathway, is also modulated by gangliosides.	Gangliosides	161-173	rolled	Drosophila melanogaster	45-82
32731387-5	2020	Studies of GM3S KO cells have shown that the extracellular signal-regulated kinase (ERK) pathway, downstream of the LepR signaling pathway, is also modulated by gangliosides.	Gangliosides	161-173	rolled	Drosophila melanogaster	84-87
32731387-5	2020	Studies of GM3S KO cells have shown that the extracellular signal-regulated kinase (ERK) pathway, downstream of the LepR signaling pathway, is also modulated by gangliosides.	Gangliosides	161-173	leptin receptor	Mus musculus	116-120
32731387-7	2020	Gangliosides thus have the ability to modulate the effects of leptin by regulating functions of such receptors, and by direct interaction with LepR to control signaling.	Gangliosides	0-12	leptin	Mus musculus	62-68
32731387-7	2020	Gangliosides thus have the ability to modulate the effects of leptin by regulating functions of such receptors, and by direct interaction with LepR to control signaling.	Gangliosides	0-12	leptin receptor	Mus musculus	143-147
32165255-2	2020	We previously described a new PD mouse model based on heterozygous disruption of the B4galnt1 gene leading to partial deficiency of the GM1 family of gangliosides that manifested several nigrostriatal neuropathological features of PD as well as movement impairment.	Gangliosides	150-162	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	85-93
32573489-7	2020	IGSF3-deficient lymphoblastoids had high ceramide- and sphingosine-1 phosphate-, but low glycosphingolipids- and gangliosides levels; were less apoptotic and more adherent; with marked changes in multiple TNFRSF molecules.	Gangliosides	113-125	immunoglobulin superfamily member 3	Homo sapiens	0-5
32679677-4	2020	In rat models of arthritis, using MFGM fractions as dietary interventions, the phospholipid-enriched MFGM isolates were effective in reducing adjuvant-induced paw swelling while there was a tendency for the ganglioside-enriched isolate to reduce carrageenan-induced rat paw oedema.	Gangliosides	207-218	milk fat globule EGF and factor V/VIII domain containing	Rattus norvegicus	101-105
32436545-10	2020	The most significant changes in lipids in the brains of APP/PS1 mice compared to wild-type controls were related to gangliosides (GM2 36:1, GM3 36:1) and phosphatidylinositols (PI 38:4, 36:4) in regions where the accumulation of senile plaques occurred.	Gangliosides	116-128	presenilin 1	Mus musculus	60-63
31340161-2	2020	HEXB mutation reduces HexA and HexB enzymatic activities, and results in the massive accumulation of ganglioside GM2 in the nervous system.	Gangliosides	101-112	hexosaminidase B	Mus musculus	0-4
31357902-1	2020	In Tay-Sachs and Sandhoff disease, a deficiency of the lysosomal enzyme beta-hexosaminidase causes GM2 and other gangliosides to accumulate in neurons and triggers neurodegeneration.	Gangliosides	113-125	O-GlcNAcase	Mus musculus	72-91
32457377-5	2020	This was supported by equilibrium dialysis, STD-NMR experiments, and inhibition analysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjugates and a comprehensive set of ganglioside-based glycoconjugates.	Gangliosides	184-195	GRDX	Homo sapiens	92-95
32486168-5	2020	We identified a 2-gene expression signature combining ganglioside synthase genes ST8SIA1 and B4GALNT1 that serves as a more efficient predictor of GD2-positive phenotype (Matthews Correlation Coefficient (MCC) 0.32, 0.88, and 0.98 in three independent comparisons) compared to the individual ganglioside biosynthesis genes (MCC 0.02-0.32, 0.1-0.75, and 0.04-1 for the same independent comparisons).	Gangliosides	54-65	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	81-88
32486168-5	2020	We identified a 2-gene expression signature combining ganglioside synthase genes ST8SIA1 and B4GALNT1 that serves as a more efficient predictor of GD2-positive phenotype (Matthews Correlation Coefficient (MCC) 0.32, 0.88, and 0.98 in three independent comparisons) compared to the individual ganglioside biosynthesis genes (MCC 0.02-0.32, 0.1-0.75, and 0.04-1 for the same independent comparisons).	Gangliosides	54-65	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	93-101
32486168-5	2020	We identified a 2-gene expression signature combining ganglioside synthase genes ST8SIA1 and B4GALNT1 that serves as a more efficient predictor of GD2-positive phenotype (Matthews Correlation Coefficient (MCC) 0.32, 0.88, and 0.98 in three independent comparisons) compared to the individual ganglioside biosynthesis genes (MCC 0.02-0.32, 0.1-0.75, and 0.04-1 for the same independent comparisons).	Gangliosides	292-303	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	81-88
32486168-5	2020	We identified a 2-gene expression signature combining ganglioside synthase genes ST8SIA1 and B4GALNT1 that serves as a more efficient predictor of GD2-positive phenotype (Matthews Correlation Coefficient (MCC) 0.32, 0.88, and 0.98 in three independent comparisons) compared to the individual ganglioside biosynthesis genes (MCC 0.02-0.32, 0.1-0.75, and 0.04-1 for the same independent comparisons).	Gangliosides	292-303	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	93-101
32457377-5	2020	This was supported by equilibrium dialysis, STD-NMR experiments, and inhibition analysis of GD3-binding toward Siglec-7 using synthetic sialoglycoconjugates and a comprehensive set of ganglioside-based glycoconjugates.	Gangliosides	184-195	sialic acid binding Ig like lectin 7	Homo sapiens	111-119
32477123-8	2020	One of the signaling pathways that may be involved in the activation of these proteases is the MAPK pathway, since phosphorylation of ERK1/2 was observed in cells treated with SMase D. Confocal analysis showed a strong colocalization between SMase D and GM1 ganglioside present in rafts.	Gangliosides	258-269	mitogen-activated protein kinase 3	Homo sapiens	134-140
31707730-1	2020	2-Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) is an experimental therapy for Niemann-Pick disease type C (NPC) that reduced neuronal cholesterol and ganglioside storage, reduced Purkinje cell death, and increased lifespan in npc1-/- mice and NPC1 cats.	Gangliosides	150-161	beta-carotene oxygenase 1	Mus musculus	38-45
31792756-4	2020	This study aimed to clarify the role of ganglioside in fish TG metabolism, with particular reference to Neu3a, a ganglioside-specific sialidase expressed in the fish liver.	Gangliosides	113-124	sialidase-3	Oryzias latipes	104-109
32325905-1	2020	Ganglioside GM1 (GM1) has been reported to functionally recover degenerated nervous system in vitro and in vivo, but the possibility to translate GM1"s potential in clinical settings is counteracted by its low ability to overcome the blood-brain barrier (BBB) due to its amphiphilic nature.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-15
32325905-1	2020	Ganglioside GM1 (GM1) has been reported to functionally recover degenerated nervous system in vitro and in vivo, but the possibility to translate GM1"s potential in clinical settings is counteracted by its low ability to overcome the blood-brain barrier (BBB) due to its amphiphilic nature.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	17-20
32325905-1	2020	Ganglioside GM1 (GM1) has been reported to functionally recover degenerated nervous system in vitro and in vivo, but the possibility to translate GM1"s potential in clinical settings is counteracted by its low ability to overcome the blood-brain barrier (BBB) due to its amphiphilic nature.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	17-20
31792756-9	2020	To examine which ganglioside regulates these events, alterations of ganglioside composition in Neu3a cells were analyzed.	Gangliosides	68-79	sialidase-4-like	Oreochromis niloticus	95-100
31961140-8	2020	Measurements of the hydrolysis kinetics of CUPRA substrates containing ganglioside oligosaccharides by the glycosyl hydrolase human neuraminidase 3 served to validate the reliability of kinetic parameters measured by CUPRA-ZYME and highlight its use in establishing catalytic pathways.	Gangliosides	71-82	neuraminidase 3	Homo sapiens	132-147
31944669-4	2020	Here, with goal of directly establishing the existence of heteromultivalent GSL interactions and elucidating the mechanism underlying their formation, we investigated cholera toxin B subunit homopentamer (CTB5) binding to ganglioside mixtures in model membranes (nanodiscs) using native mass spectrometry (MS) and competitive ligand binding.	Gangliosides	222-233	cathepsin A	Homo sapiens	76-79
32192217-2	2020	O-acetylation of gangliosides is dependent on sialyl-O-acetyltransferases and sialyl-O-acetyl-esterase activities.	Gangliosides	17-29	sterol O-acyltransferase 1	Homo sapiens	46-73
32054864-3	2020	Here, based on a genome-wide CRISPR-Cas9 genetic screen for genes required for GPI side-chain modification by galactose in the Golgi apparatus, we report that beta1,3-galactosyltransferase 4 (B3GALT4), the previously characterized GM1 ganglioside synthase, additionally functions in transferring galactose to the N-acetylgalactosamine side-chain of GPI.	Gangliosides	235-246	beta-1,3-galactosyltransferase 4	Homo sapiens	192-199
32054864-3	2020	Here, based on a genome-wide CRISPR-Cas9 genetic screen for genes required for GPI side-chain modification by galactose in the Golgi apparatus, we report that beta1,3-galactosyltransferase 4 (B3GALT4), the previously characterized GM1 ganglioside synthase, additionally functions in transferring galactose to the N-acetylgalactosamine side-chain of GPI.	Gangliosides	235-246	beta-1,3-galactosyltransferase 4	Homo sapiens	159-190
31584066-8	2020	In fact, our patients lacking ST3GAL3 activity synthesize the CA19.9 epitope sialyl-Lewis a, but not all glycans necessary for fine brain functions, where the role of minor gangliosides deserves further attention.	Gangliosides	173-185	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	30-37
32028715-4	2020	Gangliosides, in particular GM1, have been shown to participate in the regulation of the function of ion channels, such as transient receptor potential vanilloid type 1 (TRPV1), a molecular integrator of noxious stimuli of distinct nature.	Gangliosides	0-12	transient receptor potential cation channel subfamily V member 1	Homo sapiens	123-168
32028715-4	2020	Gangliosides, in particular GM1, have been shown to participate in the regulation of the function of ion channels, such as transient receptor potential vanilloid type 1 (TRPV1), a molecular integrator of noxious stimuli of distinct nature.	Gangliosides	0-12	transient receptor potential cation channel subfamily V member 1	Homo sapiens	170-175
31168055-0	2020	Ganglioside deficiency in hypothalamic POMC neurons promotes body weight gain.	Gangliosides	0-11	pro-opiomelanocortin-alpha	Mus musculus	39-43
31168055-1	2020	BACKGROUND: Glucosylceramide synthase (GCS; gene: UDP-glucose:ceramide glucosyltransferase (Ugcg))-derived gangliosides comprise a specific class of lipids in the plasma membrane that modulate the activity of transmembrane receptors.	Gangliosides	107-119	UDP-glucose ceramide glucosyltransferase	Mus musculus	12-37
31168055-1	2020	BACKGROUND: Glucosylceramide synthase (GCS; gene: UDP-glucose:ceramide glucosyltransferase (Ugcg))-derived gangliosides comprise a specific class of lipids in the plasma membrane that modulate the activity of transmembrane receptors.	Gangliosides	107-119	UDP-glucose ceramide glucosyltransferase	Mus musculus	50-90
31168055-1	2020	BACKGROUND: Glucosylceramide synthase (GCS; gene: UDP-glucose:ceramide glucosyltransferase (Ugcg))-derived gangliosides comprise a specific class of lipids in the plasma membrane that modulate the activity of transmembrane receptors.	Gangliosides	107-119	UDP-glucose ceramide glucosyltransferase	Mus musculus	92-96
31168055-7	2020	Moreover, the CRISPR (clustered regulatory interspaced short palindromic repeats)/Cas9 technology was used to inhibit GCS-dependent ganglioside biosynthesis in cultured mouse POMC neurons, yielding UgcgDelta-mHypoA-POMC cells that were used to study mechanistic aspects in further detail.	Gangliosides	132-143	pro-opiomelanocortin-alpha	Mus musculus	175-179
31168055-7	2020	Moreover, the CRISPR (clustered regulatory interspaced short palindromic repeats)/Cas9 technology was used to inhibit GCS-dependent ganglioside biosynthesis in cultured mouse POMC neurons, yielding UgcgDelta-mHypoA-POMC cells that were used to study mechanistic aspects in further detail.	Gangliosides	132-143	pro-opiomelanocortin-alpha	Mus musculus	215-219
31168055-10	2020	IR, IRS-2, p85, and overall insulin-evoked IR and IRS-2 phosphorylation were elevated in ganglioside-depleted UgcgDelta-mHypoA-POMC neurons.	Gangliosides	89-100	insulin receptor	Mus musculus	0-2
31168055-10	2020	IR, IRS-2, p85, and overall insulin-evoked IR and IRS-2 phosphorylation were elevated in ganglioside-depleted UgcgDelta-mHypoA-POMC neurons.	Gangliosides	89-100	insulin receptor substrate 2	Mus musculus	4-9
31168055-10	2020	IR, IRS-2, p85, and overall insulin-evoked IR and IRS-2 phosphorylation were elevated in ganglioside-depleted UgcgDelta-mHypoA-POMC neurons.	Gangliosides	89-100	extracellular matrix protein 1	Mus musculus	11-14
31168055-10	2020	IR, IRS-2, p85, and overall insulin-evoked IR and IRS-2 phosphorylation were elevated in ganglioside-depleted UgcgDelta-mHypoA-POMC neurons.	Gangliosides	89-100	insulin receptor substrate 2	Mus musculus	50-55
31168055-10	2020	IR, IRS-2, p85, and overall insulin-evoked IR and IRS-2 phosphorylation were elevated in ganglioside-depleted UgcgDelta-mHypoA-POMC neurons.	Gangliosides	89-100	pro-opiomelanocortin-alpha	Mus musculus	127-131
31168055-11	2020	A PLA demonstrated that more insulin-evoked complex formation occurred between PIP3 and SUR-1 in ganglioside-deficient POMC neurons in vitro and in vivo.	Gangliosides	97-108	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	88-93
31168055-11	2020	A PLA demonstrated that more insulin-evoked complex formation occurred between PIP3 and SUR-1 in ganglioside-deficient POMC neurons in vitro and in vivo.	Gangliosides	97-108	pro-opiomelanocortin-alpha	Mus musculus	119-123
31168055-14	2020	Moreover, gangliosides might modulate KATP channel activity by restraining PIP3 binding to the KATP channel subunit SUR-1.	Gangliosides	10-22	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	116-121
31168055-15	2020	Increased PIP3/SUR-1 interactions in ganglioside-deficient neurons could in turn potentially lead to electrical silencing.	Gangliosides	37-48	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	Mus musculus	15-20
31168055-16	2020	This work highlights that gangliosides in POMC neurons of the hypothalamic Arc are important regulators of body weight.	Gangliosides	26-38	pro-opiomelanocortin-alpha	Mus musculus	42-46
32033474-4	2020	Moreover, ecto-ST8Sia-I can synthetize GD3 ganglioside at the cell surface in lipopolysaccharide (LPS)-stimulated macrophages even when LPS-stimulated macrophages reduced the total ST8Sia-I expression levels.	Gangliosides	43-54	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	15-23
32033474-6	2020	The diminution of ST8Sia-I expression in LPS-stimulated macrophages correlated with a reduction of GD3 and GM1 gangliosides and with an increment of GD1a.	Gangliosides	111-123	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	18-26
32033474-6	2020	The diminution of ST8Sia-I expression in LPS-stimulated macrophages correlated with a reduction of GD3 and GM1 gangliosides and with an increment of GD1a.	Gangliosides	111-123	coenzyme Q10A	Mus musculus	107-110
31988291-0	2020	B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2.	Gangliosides	130-141	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	0-8
31988291-0	2020	B4GALNT1 induces angiogenesis, anchorage independence growth and motility, and promotes tumorigenesis in melanoma by induction of ganglioside GM2/GD2.	Gangliosides	130-141	cytochrome b5 domain containing 2	Mus musculus	142-145
31500807-4	2019	Crb3-knockout (KO) cells showed a remarkable increase in ganglioside GM3 (GM3) on the cell surface.	Gangliosides	57-68	crumbs cell polarity complex component 3	Homo sapiens	0-4
31774647-3	2020	It has been widely suggested that long chain (sphingosine) base (LCBs), C18:1-LCB and C20:1-LCB, containing gangliosides might play different roles in neuronal function in vivo.	Gangliosides	108-120	clathrin, light polypeptide (Lcb)	Mus musculus	65-68
31989751-0	2020	Corrigendum: Ganglioside GM1 promotes contact inhibition of growth by regulating the localization of epidermal growth factor receptor from glycosphingolipid-enriched microdomain to caveolae Article DOI: 10.1111/cpr.12639.	Gangliosides	13-24	epidermal growth factor receptor	Homo sapiens	101-133
32046393-0	2020	Exogenous Ganglioside GT1b Enhances Porcine Oocyte Maturation, Including the Cumulus Cell Expansion and Activation of EGFR and ERK1/2 Signaling.	Gangliosides	10-21	epidermal growth factor receptor	Homo sapiens	118-122
32046393-0	2020	Exogenous Ganglioside GT1b Enhances Porcine Oocyte Maturation, Including the Cumulus Cell Expansion and Activation of EGFR and ERK1/2 Signaling.	Gangliosides	10-21	mitogen-activated protein kinase 3	Homo sapiens	127-133
32046393-1	2020	Ganglioside GT1b is well-known for its role in cytokine production and in activating epidermal growth factor receptor (EGFR)-mediated signaling pathways in cancer cells.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	85-117
32046393-1	2020	Ganglioside GT1b is well-known for its role in cytokine production and in activating epidermal growth factor receptor (EGFR)-mediated signaling pathways in cancer cells.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	119-123
31861617-5	2019	Such is the case for distant enveloped viruses like human immunodeficiency virus (HIV)-1 or Ebola virus (EBOV), which incorporate sialic acid-containing gangliosides on their viral membrane and are effectively recognized by Siglec-1.	Gangliosides	153-165	sialic acid binding Ig like lectin 1	Homo sapiens	224-232
31807237-5	2020	Importantly, CD82-cholesterol/-lipid raft interaction not only promotes extracellular release of lipid raft components such as cholesterol and gangliosides but also facilitates extracellular vesicle (EV)-mediated release of ezrin-radixin-moesin (ERM) protein Ezrin.	Gangliosides	143-155	CD82 molecule	Homo sapiens	13-17
31917338-7	2020	Since intrathecal injection of b-series ganglioside induced mechanical allodynia in naive mice, it seems reasonable that b-series gangliosides synthesized from upregulated St8sia1 in the ipsilateral spinal cord are involved in mechanical allodynia.	Gangliosides	40-51	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	172-179
31917338-7	2020	Since intrathecal injection of b-series ganglioside induced mechanical allodynia in naive mice, it seems reasonable that b-series gangliosides synthesized from upregulated St8sia1 in the ipsilateral spinal cord are involved in mechanical allodynia.	Gangliosides	130-142	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	172-179
32477604-10	2020	The GM1 ganglioside presumably shielded MTX liposomes from phagocytosis by one of the monocyte populations and increased the efficiency of monocyte uptake by another population, probably one expressing C3b-binding receptors (C3b was detected on liposomes after incubation with blood plasma).	Gangliosides	8-19	complement C3	Homo sapiens	202-205
32477604-10	2020	The GM1 ganglioside presumably shielded MTX liposomes from phagocytosis by one of the monocyte populations and increased the efficiency of monocyte uptake by another population, probably one expressing C3b-binding receptors (C3b was detected on liposomes after incubation with blood plasma).	Gangliosides	8-19	complement C3	Homo sapiens	225-228
32664815-1	2020	Ganglioside GM3 synthase (alpha-2,3-sialyltransferase, ST3GAL5, GM3S) is a key enzyme involved in the biosynthesis of gangliosides.	Gangliosides	118-130	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-24
32664815-1	2020	Ganglioside GM3 synthase (alpha-2,3-sialyltransferase, ST3GAL5, GM3S) is a key enzyme involved in the biosynthesis of gangliosides.	Gangliosides	118-130	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	55-62
32046393-0	2020	Exogenous Ganglioside GT1b Enhances Porcine Oocyte Maturation, Including the Cumulus Cell Expansion and Activation of EGFR and ERK1/2 Signaling.	Gangliosides	10-21	beta-1,4-galactosyltransferase 1	Homo sapiens	22-25
31852959-3	2019	Thus, this study supports the idea that the Parkinson"s phenotype expressed by the B4galnt1+/- mice is due to a reduced level of neuronal ganglioside content and lack of interactions between the oligosaccharide portion of GM1 with specific membrane proteins.	Gangliosides	138-149	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	83-91
31698188-0	2019	GM1 Ganglioside role in the interaction of Alpha-synuclein with lipid membranes: Morphology and structure.	Gangliosides	4-15	synuclein alpha	Homo sapiens	43-58
31698188-3	2019	Here we propose a multi-technique approach to study the effects of AS in its monomeric and oligomeric forms on artificial lipid membranes containing GM1 ganglioside.	Gangliosides	153-164	synuclein alpha	Homo sapiens	67-69
31698188-6	2019	We observe the monomer- and oligomer-interactions are both limited to the external membrane leaflet and that the presence of ganglioside leads to a stronger interaction of the membranes and AS in its monomeric and oligomeric forms with a stronger aggressiveness in the latter.	Gangliosides	125-136	synuclein alpha	Homo sapiens	190-192
32029028-19	2019	The mRNA expressions of Wnt3a and beta-catenin in the hippocampus and the contents of BDNF and NGF in serum were significantly higher than those in the model group 1 day after GA or DG was added, the mRNA expressions of GSK-3beta and Axin were significantly decreased, and the effect of DG was more significant than that of GA [Wnt3a mRNA (2-DeltaDeltaCt): 3.51+-0.14 vs. 2.93+-0.05, beta-catenin mRNA (2-DeltaDeltaCt): 1.90+-0.08 vs. 1.75+-0.04, BDNF (ng/L): 4.06+-0.55 vs. 3.16+-0.64, NGF (ng/L): 9.53+-1.08 vs. 7.26+-0.43, GSK-3beta mRNA (2-DeltaDeltaCt): 0.75+-0.01 vs. 0.79+-0.01, Axin mRNA (2-DeltaDeltaCt): 0.74+-0.02 vs. 0.76+-0.02, all P < 0.05].	Gangliosides	176-178	Wnt family member 3A	Rattus norvegicus	24-29
32029028-19	2019	The mRNA expressions of Wnt3a and beta-catenin in the hippocampus and the contents of BDNF and NGF in serum were significantly higher than those in the model group 1 day after GA or DG was added, the mRNA expressions of GSK-3beta and Axin were significantly decreased, and the effect of DG was more significant than that of GA [Wnt3a mRNA (2-DeltaDeltaCt): 3.51+-0.14 vs. 2.93+-0.05, beta-catenin mRNA (2-DeltaDeltaCt): 1.90+-0.08 vs. 1.75+-0.04, BDNF (ng/L): 4.06+-0.55 vs. 3.16+-0.64, NGF (ng/L): 9.53+-1.08 vs. 7.26+-0.43, GSK-3beta mRNA (2-DeltaDeltaCt): 0.75+-0.01 vs. 0.79+-0.01, Axin mRNA (2-DeltaDeltaCt): 0.74+-0.02 vs. 0.76+-0.02, all P < 0.05].	Gangliosides	176-178	catenin beta 1	Rattus norvegicus	34-46
32029028-19	2019	The mRNA expressions of Wnt3a and beta-catenin in the hippocampus and the contents of BDNF and NGF in serum were significantly higher than those in the model group 1 day after GA or DG was added, the mRNA expressions of GSK-3beta and Axin were significantly decreased, and the effect of DG was more significant than that of GA [Wnt3a mRNA (2-DeltaDeltaCt): 3.51+-0.14 vs. 2.93+-0.05, beta-catenin mRNA (2-DeltaDeltaCt): 1.90+-0.08 vs. 1.75+-0.04, BDNF (ng/L): 4.06+-0.55 vs. 3.16+-0.64, NGF (ng/L): 9.53+-1.08 vs. 7.26+-0.43, GSK-3beta mRNA (2-DeltaDeltaCt): 0.75+-0.01 vs. 0.79+-0.01, Axin mRNA (2-DeltaDeltaCt): 0.74+-0.02 vs. 0.76+-0.02, all P < 0.05].	Gangliosides	176-178	brain-derived neurotrophic factor	Rattus norvegicus	86-90
32029028-19	2019	The mRNA expressions of Wnt3a and beta-catenin in the hippocampus and the contents of BDNF and NGF in serum were significantly higher than those in the model group 1 day after GA or DG was added, the mRNA expressions of GSK-3beta and Axin were significantly decreased, and the effect of DG was more significant than that of GA [Wnt3a mRNA (2-DeltaDeltaCt): 3.51+-0.14 vs. 2.93+-0.05, beta-catenin mRNA (2-DeltaDeltaCt): 1.90+-0.08 vs. 1.75+-0.04, BDNF (ng/L): 4.06+-0.55 vs. 3.16+-0.64, NGF (ng/L): 9.53+-1.08 vs. 7.26+-0.43, GSK-3beta mRNA (2-DeltaDeltaCt): 0.75+-0.01 vs. 0.79+-0.01, Axin mRNA (2-DeltaDeltaCt): 0.74+-0.02 vs. 0.76+-0.02, all P < 0.05].	Gangliosides	324-326	brain-derived neurotrophic factor	Rattus norvegicus	86-90
32029028-19	2019	The mRNA expressions of Wnt3a and beta-catenin in the hippocampus and the contents of BDNF and NGF in serum were significantly higher than those in the model group 1 day after GA or DG was added, the mRNA expressions of GSK-3beta and Axin were significantly decreased, and the effect of DG was more significant than that of GA [Wnt3a mRNA (2-DeltaDeltaCt): 3.51+-0.14 vs. 2.93+-0.05, beta-catenin mRNA (2-DeltaDeltaCt): 1.90+-0.08 vs. 1.75+-0.04, BDNF (ng/L): 4.06+-0.55 vs. 3.16+-0.64, NGF (ng/L): 9.53+-1.08 vs. 7.26+-0.43, GSK-3beta mRNA (2-DeltaDeltaCt): 0.75+-0.01 vs. 0.79+-0.01, Axin mRNA (2-DeltaDeltaCt): 0.74+-0.02 vs. 0.76+-0.02, all P < 0.05].	Gangliosides	324-326	glycogen synthase kinase 3 alpha	Rattus norvegicus	220-229
31222470-2	2019	In this study, we investigated the binding of hIAPP to bilayers consisting of ganglioside lipids and dioleoylphosphatidylcholine (DOPC), which is a physiologically relevant lipid species for pancreatic beta cell-associated aggregation.	Gangliosides	78-89	islet amyloid polypeptide	Homo sapiens	46-51
31373757-8	2019	On the other hand, OGT silencing perturbs biosynthesis of glycosphingolipids resulting in a decrease in gangliosides and an increase in globosides.	Gangliosides	104-116	O-linked N-acetylglucosamine (GlcNAc) transferase	Homo sapiens	19-22
31653037-2	2019	In this study, scFv fragments of GD2-specific antibodies 14.18 were produced in a mammalian expression system that specifically bind to ganglioside GD2, followed by site-directed pegylation to generate mono-, di-, and tetra-scFv fragments.	Gangliosides	136-147	immunglobulin heavy chain variable region	Homo sapiens	15-19
31653037-3	2019	Fractionated pegylated dimers and tetramers of scFv fragments showed significant increase of the binding to GD2 which was not accompanied by cross-reactivity with other gangliosides.	Gangliosides	169-181	immunglobulin heavy chain variable region	Homo sapiens	47-51
31578452-3	2019	In this work, an untargeted lipidomic analysis revealed that some lipid species were altered in GRP94-deficient cells, specially GM2 and GM3 gangliosides.	Gangliosides	141-153	Glycoprotein 93	Drosophila melanogaster	96-101
31222470-5	2019	We have characterized two distinct binding modes of hIAPP on ganglioside-rich membranes, with both binding modes formed due to electrostatic interaction between the cationic peptides and the anionic ganglioside headgroup.	Gangliosides	61-72	islet amyloid polypeptide	Homo sapiens	52-57
31222470-5	2019	We have characterized two distinct binding modes of hIAPP on ganglioside-rich membranes, with both binding modes formed due to electrostatic interaction between the cationic peptides and the anionic ganglioside headgroup.	Gangliosides	199-210	islet amyloid polypeptide	Homo sapiens	52-57
31222470-7	2019	In contrast, the binding of hIAPP near the ganglioside-enriched areas mobilizes the peptide, preventing it from conformational changes and potentially shields it from interactions with other peptides.	Gangliosides	43-54	islet amyloid polypeptide	Homo sapiens	28-33
31222470-8	2019	This suggests a dual role of ganglioside lipids, affecting the aggregation of hIAPP by either accelerating or inhibiting amyloid formation depending on the membrane binding and the ganglioside concentration.	Gangliosides	29-40	islet amyloid polypeptide	Homo sapiens	78-83
31222470-8	2019	This suggests a dual role of ganglioside lipids, affecting the aggregation of hIAPP by either accelerating or inhibiting amyloid formation depending on the membrane binding and the ganglioside concentration.	Gangliosides	181-192	islet amyloid polypeptide	Homo sapiens	78-83
31552332-7	2019	The lift-off points of milk ganglioside GM3 monolayer surface pressure-area isotherms spread on NSA permeates and ultrapure water subphases were significantly different when compared for the same sample, indicating that surface tension measurements obtained on ultrapure water are not the same as with NSA milk permeate.	Gangliosides	28-39	Weaning weight-maternal milk	Bos taurus	23-27
31526872-2	2019	A significant increase in ganglioside GM3 content generally happens in atherosclerotic plaques causing a GM3-enriched microenvironment.	Gangliosides	26-37	granulocyte macrophage antigen 3	Mus musculus	38-41
31526872-2	2019	A significant increase in ganglioside GM3 content generally happens in atherosclerotic plaques causing a GM3-enriched microenvironment.	Gangliosides	26-37	granulocyte macrophage antigen 3	Mus musculus	105-108
31140649-2	2019	Two of these sphingolipidoses, Tay Sachs and Sandhoff diseases, are caused by beta-Hexosaminidase (HEXB) enzyme deficiency, resulting in ganglioside (GM2) accumulation and neuronal loss.	Gangliosides	137-148	hexosaminidase B (beta polypeptide)	Danio rerio	99-103
31431523-0	2019	Gangliosides interact with synaptotagmin to form the high-affinity receptor complex for botulinum neurotoxin B. Botulinum neurotoxin type B (BoNT/B) recognizes nerve terminals by binding to 2 receptor components: a polysialoganglioside, predominantly GT1b, and synaptotagmin 1/2.	Gangliosides	0-12	synaptotagmin 12	Homo sapiens	261-278
31254056-0	2019	Mass spectrometry imaging reveals ganglioside and ceramide localization patterns during cerebellar degeneration in the Npc1-/- mouse model.	Gangliosides	34-45	NPC intracellular cholesterol transporter 1	Mus musculus	119-123
31185614-3	2019	In this study, we investigated the effects of genetic deletion of ganglioside D3 (GD3) synthase, which is responsible for the generation of all b-series gangliosides, on bone metabolism.	Gangliosides	153-165	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	66-95
31105061-3	2019	Here we show that synthetic antigens mimicking the carbohydrate moiety of GD2 or GD3 gangliosides can be used as vaccines to activate a selective humoral and cellular immunity that is therapeutic against several cancers expressing GD2 or GD3.	Gangliosides	85-97	GRDX	Homo sapiens	81-84
31105061-3	2019	Here we show that synthetic antigens mimicking the carbohydrate moiety of GD2 or GD3 gangliosides can be used as vaccines to activate a selective humoral and cellular immunity that is therapeutic against several cancers expressing GD2 or GD3.	Gangliosides	85-97	GRDX	Homo sapiens	238-241
31289278-0	2019	Antitumor effects of the GM3(Neu5Gc) ganglioside-specific humanized antibody 14F7hT against Cmah-transfected cancer cells.	Gangliosides	37-48	cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene	Homo sapiens	92-96
31258638-0	2019	Clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, NSE and S100beta.	Gangliosides	21-33	interleukin 6	Homo sapiens	122-126
31258638-0	2019	Clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, NSE and S100beta.	Gangliosides	21-33	enolase 2	Homo sapiens	128-131
31258638-0	2019	Clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, NSE and S100beta.	Gangliosides	21-33	S100 calcium binding protein B	Homo sapiens	136-144
31258638-1	2019	This study investigated the clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, neuron-specific enolase (NSE) and S100beta.	Gangliosides	49-61	interleukin 6	Homo sapiens	150-154
31258638-1	2019	This study investigated the clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, neuron-specific enolase (NSE) and S100beta.	Gangliosides	49-61	enolase 2	Homo sapiens	156-179
31258638-1	2019	This study investigated the clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, neuron-specific enolase (NSE) and S100beta.	Gangliosides	49-61	enolase 2	Homo sapiens	181-184
31258638-1	2019	This study investigated the clinical efficacy of gangliosides on premature infants suffering from white matter damage and its effect on the levels of IL-6, neuron-specific enolase (NSE) and S100beta.	Gangliosides	49-61	S100 calcium binding protein B	Homo sapiens	190-198
31197190-5	2019	GD3 is a well-studied ganglioside which is known to have roles in the development of the cerebellum.	Gangliosides	22-33	GRDX	Homo sapiens	0-3
31638570-0	2019	[Compound porcine cerebroside and ganglioside relieves brain injury and promotes expression of cerebellin 4 in neonatal mice with intrauterine hypoxia].	Gangliosides	34-45	cerebellin 4 precursor protein	Mus musculus	95-107
31638570-1	2019	Objective To study the effects of compound porcine cerebroside and ganglioside injection (CPCGI) on brain injury and expression of cerebellin 4 (CBLN4) in neonatal mice after intrauterine hypoxia.	Gangliosides	67-78	cerebellin 4 precursor protein	Mus musculus	131-143
31127673-0	2019	Ganglioside GM1 promotes contact inhibition of growth by regulating the localization of epidermal growth factor receptor from glycosphingolipid-enriched microdomain to caveolae.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	88-120
31185614-5	2019	However, the expression of these gangliosides was decreased after induction of osteoclastogenesis by receptor activator of nuclear factor kappa-B ligand (RANKL).	Gangliosides	33-45	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	101-152
31185614-5	2019	However, the expression of these gangliosides was decreased after induction of osteoclastogenesis by receptor activator of nuclear factor kappa-B ligand (RANKL).	Gangliosides	33-45	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	154-159
31110277-3	2019	The result showed that the LCKD promoted the expression of glycosyltransferase genes involved in ganglioside synthesis and suppressed the expression of Gm2a, the gene encoding GM2 ganglioside activator protein, a lysosomal protein indispensable for ganglioside degradation.	Gangliosides	97-108	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	59-78
31194046-0	2019	Prevalence of antibodies to ganglioside and Hep 2 in Gaucher, Niemann - Pick type C and Sanfilippo diseases.	Gangliosides	28-39	protein interacting with PRKCA 1	Homo sapiens	72-76
31110277-3	2019	The result showed that the LCKD promoted the expression of glycosyltransferase genes involved in ganglioside synthesis and suppressed the expression of Gm2a, the gene encoding GM2 ganglioside activator protein, a lysosomal protein indispensable for ganglioside degradation.	Gangliosides	180-191	GM2 ganglioside activator protein	Mus musculus	152-156
31110277-3	2019	The result showed that the LCKD promoted the expression of glycosyltransferase genes involved in ganglioside synthesis and suppressed the expression of Gm2a, the gene encoding GM2 ganglioside activator protein, a lysosomal protein indispensable for ganglioside degradation.	Gangliosides	180-191	cytochrome b5 domain containing 2	Mus musculus	176-179
31110277-7	2019	Further analyses suggested that the LCKD altered the expression levels of gangliosides in a limited area of central nervous system tissues susceptible to Gm2a.	Gangliosides	74-86	GM2 ganglioside activator protein	Mus musculus	154-158
30878495-3	2019	Gangliosides, as well as, other anionic lipid species with small or large headgroups were found to induce conformational changes of alpha-synuclein monomers and catalyse their aggregation at mildly acidic conditions.	Gangliosides	0-12	synuclein alpha	Homo sapiens	132-147
31013778-0	2019	Gangliosides Contribute to Vascular Insulin Resistance.	Gangliosides	0-12	insulin	Homo sapiens	36-43
30273679-8	2019	Here, an altered GM1 to GM2/GM3 ganglioside metabolism was observed in the diffuse periphery of plaques but not in the core region.	Gangliosides	32-43	coenzyme Q10A	Mus musculus	17-20
30273679-8	2019	Here, an altered GM1 to GM2/GM3 ganglioside metabolism was observed in the diffuse periphery of plaques but not in the core region.	Gangliosides	32-43	granulocyte macrophage antigen 3	Mus musculus	28-31
31013778-7	2019	Second, the expression levels of gangliosides were monitored in HAECs treated with different concentrations of tumor necrosis factor-alpha (TNFalpha) for different time intervals to mimic in vivo acute or chronic inflammatory conditions.	Gangliosides	33-45	tumor necrosis factor	Homo sapiens	111-138
31013778-7	2019	Second, the expression levels of gangliosides were monitored in HAECs treated with different concentrations of tumor necrosis factor-alpha (TNFalpha) for different time intervals to mimic in vivo acute or chronic inflammatory conditions.	Gangliosides	33-45	tumor necrosis factor	Homo sapiens	140-148
31013778-9	2019	In this review, we summarize the molecular mechanisms of insulin resistance in aged/senescent and TNFalpha-stimulated endothelial cells mediated by gangliosides and highlight the possible roles of gangliosides in vascular insulin resistance-related diseases.	Gangliosides	148-160	insulin	Homo sapiens	57-64
31013778-9	2019	In this review, we summarize the molecular mechanisms of insulin resistance in aged/senescent and TNFalpha-stimulated endothelial cells mediated by gangliosides and highlight the possible roles of gangliosides in vascular insulin resistance-related diseases.	Gangliosides	148-160	tumor necrosis factor	Homo sapiens	98-106
30842875-4	2019	Here, we use colonic epithelial and respiratory epithelial cell lines to examine how two types of CT receptors-gangliosides and fucosylated glycoconjugates-contribute to CTB internalization.	Gangliosides	111-123	phosphate cytidylyltransferase 1B, choline	Homo sapiens	170-173
30842875-7	2019	Additionally, in a cell line that harbours both classes of receptors, gangliosides dictate the efficiency of CTB internalization.	Gangliosides	70-82	phosphate cytidylyltransferase 1B, choline	Homo sapiens	109-112
30776097-1	2019	Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface.	Gangliosides	34-45	coenzyme Q10A	Mus musculus	159-162
31024530-10	2019	We observed that our previously defined anti GD3 ganglioside-binder antibody-variable region genes were present in melanoma as well.	Gangliosides	49-60	GRDX	Homo sapiens	45-48
31024530-14	2019	We not only described the isolation and specificity testing of the tumor infiltrating B cells, but also showed the TIL-B cells" highly tumor-associated GD3 ganglioside-revealing potential in melanomas.	Gangliosides	156-167	GRDX	Homo sapiens	152-155
30776097-1	2019	Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface.	Gangliosides	34-45	coenzyme Q10A	Mus musculus	46-49
30776097-1	2019	Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface.	Gangliosides	34-45	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	113-117
30776097-1	2019	Recently, we highlighted that the ganglioside GM1 promotes neuroblastoma cells differentiation by activating the TrkA receptor through the formation of a TrkA-GM1 oligosaccharide complex at the cell surface.	Gangliosides	34-45	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	154-158
30427108-8	2019	Moreover, macrophages treated with the ceramide-glucosyltransferase inhibitor (P4r) and macrophages with altered ganglioside synthesis (from B4galnt1-/- mice) showed a deficient ability to interact with Hc.	Gangliosides	113-124	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	141-149
30899760-0	2019	Neuronal Signaling by Thy-1 in Nanodomains With Specific Ganglioside Composition: Shall We Open the Door to a New Complexity?	Gangliosides	57-68	Thy-1 cell surface antigen	Homo sapiens	22-27
30899760-6	2019	Also, we assort literature suggesting the association of Thy-1 with specific components of lipid rafts such as sialic acid containing glycosphingolipids, called gangliosides.	Gangliosides	161-173	Thy-1 cell surface antigen	Homo sapiens	57-62
30899760-7	2019	Furthermore, we argue that Thy-1 positioning in nanodomains may be influenced by gangliosides.	Gangliosides	81-93	Thy-1 cell surface antigen	Homo sapiens	27-32
30822302-0	2019	TLR9-mediated dendritic cell activation uncovers mammalian ganglioside species with specific ceramide backbones that activate invariant natural killer T cells.	Gangliosides	59-70	toll like receptor 9	Homo sapiens	0-4
29900534-5	2019	Sandhoff disease results from the defective activity of beta-hexosaminidase, leading to accumulation of ganglioside GM2.	Gangliosides	104-115	O-GlcNAcase	Mus musculus	56-75
30822302-4	2019	Here, we identified two mammalian gangliosides-namely monosialoganglioside GM3 and disialoganglioside GD3-as endogenous activators for mouse iNKT cells.	Gangliosides	34-46	granulocyte macrophage antigen 3	Mus musculus	75-78
30822302-4	2019	Here, we identified two mammalian gangliosides-namely monosialoganglioside GM3 and disialoganglioside GD3-as endogenous activators for mouse iNKT cells.	Gangliosides	34-46	GRDX	Homo sapiens	102-105
30612272-1	2019	Mainly restricted to the nervous system in healthy adults, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and metastasis of neuro-ectoderm derived tumors such as melanoma and neuroblastoma.	Gangliosides	67-79	GRDX	Homo sapiens	88-91
30775460-6	2019	Further study revealed that the ALP and trefoil factor (TFF) subunits of betagamma-CAT bind to gangliosides and sulfatides, respectively.	Gangliosides	95-107	ATHS	Homo sapiens	32-35
30523158-9	2019	We provide evidence that this is through regulation of lipid rafts as Lrch4 silencing reduces cell surface gangliosides, a metric of raft abundance, as well as expression and surface display of CD14, a raft-resident LPS co-receptor.	Gangliosides	107-119	leucine-rich repeats and calponin homology (CH) domain containing 4	Mus musculus	70-75
30528226-5	2019	In contrast, beta-gal-/- mice were devoid of beta-gal enzyme activity (<=1% of wildtype), resulting in ganglioside accumulation and severe cellular vacuolation throughout the central nervous system (CNS).	Gangliosides	106-117	galactosidase, beta 1	Mus musculus	13-24
30528226-5	2019	In contrast, beta-gal-/- mice were devoid of beta-gal enzyme activity (<=1% of wildtype), resulting in ganglioside accumulation and severe cellular vacuolation throughout the central nervous system (CNS).	Gangliosides	106-117	galactosidase, beta 1	Mus musculus	13-21
30391320-3	2019	We and others have shown that inhibition of the ganglioside biosynthetic enzyme GD3 synthase (GD3S) increases endogenous levels GM1 ganglioside.	Gangliosides	48-59	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	80-92
30471358-4	2019	DESIGN: We generated knockout (KO) mice by targeting the beta1, 4-N-acetylgalactosaminyltransferase (GalNAcT) gene, which encodes an enzyme of major gangliosides synthesis, and the GD3 synthase (GD3S) gene, which encodes an enzyme of partial gangliosides synthesis.	Gangliosides	149-161	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	101-108
30471358-4	2019	DESIGN: We generated knockout (KO) mice by targeting the beta1, 4-N-acetylgalactosaminyltransferase (GalNAcT) gene, which encodes an enzyme of major gangliosides synthesis, and the GD3 synthase (GD3S) gene, which encodes an enzyme of partial gangliosides synthesis.	Gangliosides	242-254	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	101-108
30471358-10	2019	Gangliosides modulated by GalNAcT or GD3S rescued an increase of MMP-13 induced by IL-1alpha in mice lacking GalNAcT or GD3S after exogenous replenishment in vitro.	Gangliosides	0-12	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	26-33
30471358-10	2019	Gangliosides modulated by GalNAcT or GD3S rescued an increase of MMP-13 induced by IL-1alpha in mice lacking GalNAcT or GD3S after exogenous replenishment in vitro.	Gangliosides	0-12	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	37-41
30471358-10	2019	Gangliosides modulated by GalNAcT or GD3S rescued an increase of MMP-13 induced by IL-1alpha in mice lacking GalNAcT or GD3S after exogenous replenishment in vitro.	Gangliosides	0-12	matrix metallopeptidase 13	Mus musculus	65-71
30471358-10	2019	Gangliosides modulated by GalNAcT or GD3S rescued an increase of MMP-13 induced by IL-1alpha in mice lacking GalNAcT or GD3S after exogenous replenishment in vitro.	Gangliosides	0-12	interleukin 1 alpha	Mus musculus	83-92
30471358-10	2019	Gangliosides modulated by GalNAcT or GD3S rescued an increase of MMP-13 induced by IL-1alpha in mice lacking GalNAcT or GD3S after exogenous replenishment in vitro.	Gangliosides	0-12	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	109-116
30471358-10	2019	Gangliosides modulated by GalNAcT or GD3S rescued an increase of MMP-13 induced by IL-1alpha in mice lacking GalNAcT or GD3S after exogenous replenishment in vitro.	Gangliosides	0-12	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	120-124
30471358-12	2019	Moreover, the gangliosides modulated by GalNAcT are important for cartilage metabolism, suggesting that GalNAcT is a potential target molecule for the development of novel OA treatments.	Gangliosides	14-26	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	40-47
30471358-12	2019	Moreover, the gangliosides modulated by GalNAcT are important for cartilage metabolism, suggesting that GalNAcT is a potential target molecule for the development of novel OA treatments.	Gangliosides	14-26	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	104-111
30391320-3	2019	We and others have shown that inhibition of the ganglioside biosynthetic enzyme GD3 synthase (GD3S) increases endogenous levels GM1 ganglioside.	Gangliosides	48-59	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	94-98
30391320-3	2019	We and others have shown that inhibition of the ganglioside biosynthetic enzyme GD3 synthase (GD3S) increases endogenous levels GM1 ganglioside.	Gangliosides	48-59	coenzyme Q10A	Mus musculus	128-131
30346715-0	2019	Ganglioside Hp-s1 Analogue Inhibits Amyloidogenic Toxicity in Alzheimer"s Disease Model Cells.	Gangliosides	0-11	hp	Drosophila melanogaster	12-14
30521973-1	2019	B4GALNT1 is an enzyme essential for the synthesis of complex gangliosides, whose absence leads to progressive neurodegeneration with aging in mice.	Gangliosides	61-73	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	0-8
30346715-3	2019	The ganglioside Hp-s1"s analogue Hp-s1A exerts neuritogenic activity; however, its effect on AD pathology remains unknown.	Gangliosides	4-15	hp	Drosophila melanogaster	16-18
30446529-9	2019	The CST -/- x GalNAc-T -/- phenotype was fully restored to that of CST -/- mice by neuron-specific expression of complex gangliosides, but not by their glial-specific expression nor by the global expression of a-series gangliosides.	Gangliosides	121-133	cortistatin	Mus musculus	4-7
30446529-10	2019	These data indicate that sulfatide and complex b-series gangliosides on the glial and neuronal membranes, respectively, act in concert to promote NF155 and MAG in maintaining the stable axo-glial interactions essential for normal nerve function.SIGNIFICANCE STATEMENT Sulfatides and complex gangliosides are membrane glycolipids with important roles in maintaining nervous system integrity.	Gangliosides	56-68	myelin-associated glycoprotein	Mus musculus	156-159
30446529-10	2019	These data indicate that sulfatide and complex b-series gangliosides on the glial and neuronal membranes, respectively, act in concert to promote NF155 and MAG in maintaining the stable axo-glial interactions essential for normal nerve function.SIGNIFICANCE STATEMENT Sulfatides and complex gangliosides are membrane glycolipids with important roles in maintaining nervous system integrity.	Gangliosides	291-303	myelin-associated glycoprotein	Mus musculus	156-159
30446529-12	2019	The axo-glial adhesion molecules neurofascin155 (NF155) and myelin-associated glycoprotein (MAG) require membrane microdomains containing either sulfatides or complex gangliosides to localize and function effectively.	Gangliosides	167-179	myelin-associated glycoprotein	Mus musculus	60-90
30446529-12	2019	The axo-glial adhesion molecules neurofascin155 (NF155) and myelin-associated glycoprotein (MAG) require membrane microdomains containing either sulfatides or complex gangliosides to localize and function effectively.	Gangliosides	167-179	myelin-associated glycoprotein	Mus musculus	92-95
30446529-9	2019	The CST -/- x GalNAc-T -/- phenotype was fully restored to that of CST -/- mice by neuron-specific expression of complex gangliosides, but not by their glial-specific expression nor by the global expression of a-series gangliosides.	Gangliosides	121-133	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	14-22
30446529-15	2019	These findings suggest that sulfatides and complex gangliosides on opposing axo-glial membranes are responsible for essential tethering of the axo-glial junction proteins NF155 and MAG, which interact to maintain the nodal complex.	Gangliosides	51-63	myelin-associated glycoprotein	Mus musculus	181-184
30446529-9	2019	The CST -/- x GalNAc-T -/- phenotype was fully restored to that of CST -/- mice by neuron-specific expression of complex gangliosides, but not by their glial-specific expression nor by the global expression of a-series gangliosides.	Gangliosides	219-231	cortistatin	Mus musculus	4-7
31635474-1	2019	We previously reported that ganglioside GD3 is the predominant species in neural stem cells (NSCs) and reduced postnatal NSC pools are observed in both the subventricular zone and dentate gyrus (DG) of GD3-synthase knockout (GD3S-KO) mouse brains.	Gangliosides	28-39	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	202-214
31635474-6	2019	Since ganglioside expression profiles are associated not only with normal brain development but also with pathogenic mechanisms of diseases, such as Alzheimer"s disease, we anticipate that the administration of exogenous gangliosides, such as GD3 and GM1, may represent a novel and effective strategy for promoting adult neurogenesis in damaged brain for disease treatment.	Gangliosides	6-17	coenzyme Q10A	Mus musculus	251-254
31097363-1	2019	The catabolism of ganglioside GM2 is dependent on the lysosomal enzyme beta-hexosaminidase A and a supporting lipid transfer protein, the GM2 activator protein.	Gangliosides	18-29	O-GlcNAcase	Homo sapiens	71-90
30209782-0	2019	Oral Ganglioside Supplement Improves Growth and Development in Patients with Ganglioside GM3 Synthase Deficiency.	Gangliosides	5-16	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	77-101
30209782-1	2019	Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides.	Gangliosides	73-85	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-24
31474736-2	2019	A toxic fibril formation of Abeta is known to be enhanced on the ganglioside-rich lipid membrane containing some amounts of cholesterol and sphingomyelin.	Gangliosides	65-76	amyloid beta precursor protein	Homo sapiens	28-33
31474736-3	2019	This ganglioside-rich membrane is supposed to provide a hydrophobic environment that promotes the formation of Abeta fibrils.	Gangliosides	5-16	amyloid beta precursor protein	Homo sapiens	111-116
30393144-0	2019	Parkinsonian GM2 synthase knockout mice lacking mature gangliosides develop urinary dysfunction and neurogenic bladder.	Gangliosides	55-67	cytochrome b5 domain containing 2	Mus musculus	13-16
30328220-6	2019	Microvilli with branched and/or knob-like morphologies were observed and stimulated by mutations in the ganglioside-binding site of prominin-1.	Gangliosides	104-115	prominin 1	Canis lupus familiaris	132-142
29473478-4	2018	H. pylori SabA binding gangliosides were characterized as Neu5Acalpha3-neolactohexaosylceramide and Neu5Acalpha3-neolactooctaosylceramide, while the other acid human stomach glycosphingolipids characterized (sulfatide and the gangliosides GM3, GD3, GM1, Neu5Acalpha3-neolactotetraosylceramide, GD1a and GD1b) were not recognized by the bacteria.	Gangliosides	23-35	GRDX	Homo sapiens	244-247
30446565-0	2018	Sialic Acid-Dependent Inhibition of T Cells by Exosomal Ganglioside GD3 in Ovarian Tumor Microenvironments.	Gangliosides	56-67	GRDX	Homo sapiens	68-71
30446565-3	2018	In this study, we establish that GD3, a ganglioside expressed on the surface of exosomes isolated from human ovarian tumor ascites fluids, is causally linked to the functional arrest of T cells activated through their TCR.	Gangliosides	40-51	GRDX	Homo sapiens	33-36
30266834-6	2018	We show the cerebellar distribution of gangliosides GM1, GM2, and GM3, including variants of lipid chain length.	Gangliosides	39-51	coenzyme Q10A	Mus musculus	52-55
30457145-1	2018	Alzheimer"s disease (AD) is characterized by the overproduction of the amyloid-beta peptide (Abeta) which forms fibrils under the influence of raft microdomains containing the ganglioside GM1.	Gangliosides	176-187	amyloid beta precursor protein	Homo sapiens	93-98
30185102-1	2018	GM3 synthase deficiency is due to biallelic pathogenic variants in ST3GAL5, which encodes a sialyltransferase that synthesizes ganglioside GM3.	Gangliosides	127-138	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
30534177-1	2018	Our recent report showed that curcumin, polyphenolic compound isolated from the herb Curcuma longa, upregulated the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis with autophagy induction in human lung adenocarcinoma A549 cells.	Gangliosides	182-193	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	155-164
30534177-2	2018	In this study, on the contrary to this finding, we demonstrated that curcumin downregulated the gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 synthesis with autophagy induction in human colon carcinoma HCT116 cells.	Gangliosides	157-168	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	121-133
30534177-2	2018	In this study, on the contrary to this finding, we demonstrated that curcumin downregulated the gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 synthesis with autophagy induction in human colon carcinoma HCT116 cells.	Gangliosides	157-168	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	135-144
30462668-1	2018	Ganglioside GD3 is widely expressed in human malignant melanomas, and has been reported to be involved in the increased cell proliferation and invasion.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
30462668-3	2018	The phenotypes of established ganglioside-expressing cells were quite different, i.e. cell growth increased as following order; GD2+, GD3+ > GM1+, GM2+, GM3+ cells.	Gangliosides	30-41	GRDX	Homo sapiens	134-137
30185102-1	2018	GM3 synthase deficiency is due to biallelic pathogenic variants in ST3GAL5, which encodes a sialyltransferase that synthesizes ganglioside GM3.	Gangliosides	127-138	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	67-74
30257562-3	2018	According to evidence from spectroscopic studies, ganglioside clusters are key to the fibrillization process of Abeta.	Gangliosides	50-61	amyloid beta precursor protein	Homo sapiens	112-117
30242108-0	2018	NPC1L1-dependent intestinal cholesterol absorption requires ganglioside GM3 in membrane microdomains.	Gangliosides	60-71	NPC1 like intracellular cholesterol transporter 1	Mus musculus	0-6
30242108-3	2018	Intestinal cholesterol uptake is mediated by Niemann-Pick C1-like 1 (NPC1L1), a transmembrane protein localized in membrane microdomains (lipid rafts) enriched in gangliosides and cholesterol.	Gangliosides	163-175	NPC1 like intracellular cholesterol transporter 1	Mus musculus	45-67
30242108-3	2018	Intestinal cholesterol uptake is mediated by Niemann-Pick C1-like 1 (NPC1L1), a transmembrane protein localized in membrane microdomains (lipid rafts) enriched in gangliosides and cholesterol.	Gangliosides	163-175	NPC1 like intracellular cholesterol transporter 1	Mus musculus	69-75
30242108-4	2018	The roles of gangliosides, such as monosialodihexosylganglioside (GM3) and its synthesizing enzyme GM3 synthase (GM3S), in NPC1L1-dependent cholesterol uptake have not been examined previously.	Gangliosides	13-25	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	113-117
30242108-4	2018	The roles of gangliosides, such as monosialodihexosylganglioside (GM3) and its synthesizing enzyme GM3 synthase (GM3S), in NPC1L1-dependent cholesterol uptake have not been examined previously.	Gangliosides	13-25	NPC1 like intracellular cholesterol transporter 1	Mus musculus	123-129
30242108-7	2018	Our findings suggest that GM3 and related gangliosides are essential for NPC1L1-mediated intestinal cholesterol absorption and are potential targets for hypercholesterolemia therapy.	Gangliosides	42-54	NPC1 like intracellular cholesterol transporter 1	Mus musculus	73-79
30018137-2	2018	Abeta accumulates at nanoclusters enriched in neuronal lipids called gangliosides in the presynaptic neuronal membrane, and the resulting oligomeric and/or fibrous forms accelerate the development of Alzheimer"s disease.	Gangliosides	69-81	amyloid beta precursor protein	Homo sapiens	0-5
28844489-4	2018	Herein, we developed a system to physiologically analyze ganglioside GM1-enriched lipid rafts in brain tissues using the "Enzyme-Mediated Activation of Radical Sources (EMARS)" method that we reported (Kotani N. et al.	Gangliosides	57-68	coenzyme Q10A	Mus musculus	69-72
28844489-10	2018	The EMARS method was applied to acute brain slices prepared from mouse brains in aCSF solution using the EMARS probe, HRP-conjugated cholera toxin subunit B, which recognizes ganglioside GM1.	Gangliosides	175-186	coenzyme Q10A	Mus musculus	187-190
30327713-0	2018	Heme Oxygenase-1 May Affect Cell Signalling via Modulation of Ganglioside Composition.	Gangliosides	62-73	heme oxygenase 1	Homo sapiens	0-16
30327713-4	2018	The aim of this study was to assess the possible role of Hmox1 in ganglioside metabolism in relation to oxidative stress.	Gangliosides	66-77	heme oxygenase 1	Homo sapiens	57-62
30327713-6	2018	To elucidate the possible underlying mechanisms between Hmox1 and ganglioside metabolism, hepatoblastoma HepG2 and neuroblastoma SH-SY5Y cell lines were used for in vitro experiments.	Gangliosides	66-77	heme oxygenase 1	Homo sapiens	56-61
30327713-7	2018	Mice lacking Hmox1 exhibited a significant increase in concentrations of liver and brain gangliosides and in mRNA expression of the key enzymes of ganglioside metabolism.	Gangliosides	89-101	heme oxygenase 1	Mus musculus	13-18
30327713-7	2018	Mice lacking Hmox1 exhibited a significant increase in concentrations of liver and brain gangliosides and in mRNA expression of the key enzymes of ganglioside metabolism.	Gangliosides	89-100	heme oxygenase 1	Mus musculus	13-18
30018137-6	2018	We also found that the fibrils obtained at GM1-rich nanoclusters were generated from turn Abeta40 Our findings indicate that Abeta generally self-assembles into antiparallel beta-structures but can also form protofibrils with parallel beta-sheets by interacting with ganglioside-bound Abeta.	Gangliosides	267-278	amyloid beta precursor protein	Homo sapiens	90-95
30018137-6	2018	We also found that the fibrils obtained at GM1-rich nanoclusters were generated from turn Abeta40 Our findings indicate that Abeta generally self-assembles into antiparallel beta-structures but can also form protofibrils with parallel beta-sheets by interacting with ganglioside-bound Abeta.	Gangliosides	267-278	amyloid beta precursor protein	Homo sapiens	125-130
30018137-7	2018	We concluded that by promoting the formation of parallel beta-sheets, highly ganglioside-enriched nanoclusters help accelerate the elongation of Abeta fibrils.	Gangliosides	77-88	amyloid beta precursor protein	Homo sapiens	145-150
30018137-8	2018	These results advance our understanding of ganglioside-induced Abeta fibril formation in neuronal membranes and may help inform the development of additional therapies for Alzheimer"s disease.	Gangliosides	43-54	amyloid beta precursor protein	Homo sapiens	63-68
30114188-8	2018	Our results indicate that LacCer synthase is encoded by B4galt5 and 6 genes in the CNS, and that gangliosides are indispensable for neuronal maturation, PNN formation, and axonal and myelin formation.	Gangliosides	97-109	pinin	Mus musculus	153-156
30190579-3	2018	In the present study, we have found a significant reduction of GM1 ganglioside levels in the cortex in a closed head traumatic brain injury model of a mouse, induced by a weight drop device.	Gangliosides	67-78	coenzyme Q10A	Mus musculus	63-66
30077783-3	2018	Gangliosides, as well as, other anionic lipid species with small or large headgroups were found to induce conformational changes of alpha-synuclein monomers and catalyse their aggregation at mildly acidic conditions.	Gangliosides	0-12	synuclein alpha	Homo sapiens	132-147
30004453-3	2018	In parallel with autophagy induction, the gene expression of human GD3 synthase (hST8Sia I) responsible for ganglioside GD3 synthesis was markedly elevated in response to curcumin in the A549 cells.	Gangliosides	108-119	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	81-90
29983310-1	2018	Among the numerous congenital disorders of glycosylation concerning glycoproteins, only a single mutation in ganglioside biosynthesis had been reported until a few years ago: one in the ST3GAL5 gene, encoding GM3 synthase.	Gangliosides	109-120	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	186-193
29983310-1	2018	Among the numerous congenital disorders of glycosylation concerning glycoproteins, only a single mutation in ganglioside biosynthesis had been reported until a few years ago: one in the ST3GAL5 gene, encoding GM3 synthase.	Gangliosides	109-120	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	209-221
30111401-3	2018	Effects of different concentration of ganglioside GM3 on the mRNA expression level of BCL-2 and BAX were detected by Real-time PCR.	Gangliosides	38-49	BCL2 apoptosis regulator	Homo sapiens	86-91
30111401-3	2018	Effects of different concentration of ganglioside GM3 on the mRNA expression level of BCL-2 and BAX were detected by Real-time PCR.	Gangliosides	38-49	BCL2 associated X, apoptosis regulator	Homo sapiens	96-99
30022069-0	2018	Crystal structure of an L chain optimised 14F7 anti-ganglioside Fv suggests a unique tumour-specificity through an unusual H-chain CDR3 architecture.	Gangliosides	52-63	CDR3	Homo sapiens	131-135
29558805-5	2018	A higher activity of ganglioside Hp-s1 analogue on IL-17A transcript upregulation than ganglioside Hp-s1 was found.	Gangliosides	21-32	interleukin 17A	Homo sapiens	51-57
29949766-3	2018	Here, we show that spatacsin, which is required for lysosome recycling and whose loss of function leads to hereditary spastic paraplegia 11 (SPG11), promotes clearance of gangliosides from lysosomes in mouse and human SPG11 models.	Gangliosides	171-183	SPG11, spatacsin vesicle trafficking associated	Mus musculus	19-28
29949766-3	2018	Here, we show that spatacsin, which is required for lysosome recycling and whose loss of function leads to hereditary spastic paraplegia 11 (SPG11), promotes clearance of gangliosides from lysosomes in mouse and human SPG11 models.	Gangliosides	171-183	SPG11, spatacsin vesicle trafficking associated	Mus musculus	118-139
29949766-3	2018	Here, we show that spatacsin, which is required for lysosome recycling and whose loss of function leads to hereditary spastic paraplegia 11 (SPG11), promotes clearance of gangliosides from lysosomes in mouse and human SPG11 models.	Gangliosides	171-183	SPG11, spatacsin vesicle trafficking associated	Mus musculus	141-146
29949766-3	2018	Here, we show that spatacsin, which is required for lysosome recycling and whose loss of function leads to hereditary spastic paraplegia 11 (SPG11), promotes clearance of gangliosides from lysosomes in mouse and human SPG11 models.	Gangliosides	171-183	SPG11 vesicle trafficking associated, spatacsin	Homo sapiens	218-223
29949766-4	2018	We demonstrate that spatacsin acts downstream of clathrin and recruits dynamin to allow lysosome membrane recycling and clearance of gangliosides from lysosomes.	Gangliosides	133-145	SPG11 vesicle trafficking associated, spatacsin	Homo sapiens	20-29
29949766-6	2018	In contrast, decreasing ganglioside synthesis prevented neurodegeneration and improved motor phenotype in a SPG11 zebrafish model.	Gangliosides	24-35	SPG11 vesicle trafficking associated, spatacsin	Danio rerio	108-113
29601870-0	2018	Anti-GM1 ganglioside antibodies modulate membrane-associated sphingomyelin metabolism by altering neutral sphingomyelinase activity.	Gangliosides	9-20	sphingomyelin phosphodiesterase 2	Homo sapiens	98-122
29902255-8	2018	These data show that residual neuromelanin-containing neurons in the PD SN have decreased expression of the ganglioside biosynthetic genes B3GALT4 and ST3GAL2, consistent with previous reports of decreased levels of gangliosides GM1, GD1a, GD1b and GT1b in the PD SN.	Gangliosides	108-119	beta-1,3-galactosyltransferase 4	Homo sapiens	139-146
29902255-8	2018	These data show that residual neuromelanin-containing neurons in the PD SN have decreased expression of the ganglioside biosynthetic genes B3GALT4 and ST3GAL2, consistent with previous reports of decreased levels of gangliosides GM1, GD1a, GD1b and GT1b in the PD SN.	Gangliosides	108-119	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Homo sapiens	151-158
29973867-4	2018	The enzyme glucosylceramide synthase (GCS) catalyzes the rate-limiting step in the biosynthesis of these gangliosides.	Gangliosides	105-117	UDP-glucose ceramide glucosyltransferase	Mus musculus	11-36
29973867-4	2018	The enzyme glucosylceramide synthase (GCS) catalyzes the rate-limiting step in the biosynthesis of these gangliosides.	Gangliosides	105-117	UDP-glucose ceramide glucosyltransferase	Mus musculus	38-41
29248893-2	2018	Microstructural alterations of the nodal region are the key to understand the pathophysiology of neuropathies with antibodies to gangliosides and the new category of nodo-paranodopathy has been proposed to better characterise these disorders and overcome some inadequacies of the dichotomous classification.	Gangliosides	129-141	nodal growth differentiation factor	Homo sapiens	35-40
29632069-4	2018	S1P1R regulates vesicular trafficking, and its expulsion involved alpha-Syn binding to membrane-surface gangliosides.	Gangliosides	104-116	synuclein alpha	Homo sapiens	66-75
29844375-2	2018	A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue.	Gangliosides	42-54	beta amyloid protein precursor-like	Drosophila melanogaster	124-129
29844375-2	2018	A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue.	Gangliosides	42-54	beta amyloid protein precursor-like	Drosophila melanogaster	173-178
29844375-2	2018	A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue.	Gangliosides	42-53	beta amyloid protein precursor-like	Drosophila melanogaster	124-129
29844375-2	2018	A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue.	Gangliosides	42-53	beta amyloid protein precursor-like	Drosophila melanogaster	173-178
29844375-2	2018	A growing body of evidence indicates that gangliosides form a pathological platform for the generation of ganglioside-bound Abeta, which facilitates the assembly of soluble Abetas; however, the molecular mechanisms underlying the binding of Abeta to gangliosides in the brain remain unclear due to the lack of an in vivo system that may address this issue.	Gangliosides	250-262	beta amyloid protein precursor-like	Drosophila melanogaster	124-129
29844375-4	2018	We herein demonstrate that ganglioside expression is inducible in Drosophila via the expression of transgenes of ganglioside synthesis enzymes and the feeding of exogenous sialic acid, and also that the induction of ganglioside synthesis significantly accelerates Abeta assembly in vivo.	Gangliosides	27-38	beta amyloid protein precursor-like	Drosophila melanogaster	264-269
29844375-5	2018	Our results support the hypothesis that gangliosides are responsible for Abeta assembly in vivo and also provide an opportunity to develop a valuable model for basic research as well as a therapeutic strategy for AD.	Gangliosides	40-52	beta amyloid protein precursor-like	Drosophila melanogaster	73-78
29282205-7	2018	AUTS2 in turn binds and activates the promoter of the first and rate-limiting ganglioside-producing enzyme GM3 synthase, thus fostering the synthesis of gangliosides.	Gangliosides	78-89	activator of transcription and developmental regulator AUTS2	Homo sapiens	0-5
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	Gangliosides	250-261	intraflagellar transport 172	Homo sapiens	83-86
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	Gangliosides	250-261	intraflagellar transport 172	Homo sapiens	152-155
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	Gangliosides	250-261	intraflagellar transport 172	Homo sapiens	152-155
29611693-2	2018	In this study, a G-FET device paved with a supported lipid bilayer (referred to as SLB/G-FET) was first used to monitor the catalytic hydrolysis of the SLB by phospholipase D. With excellent detection sensitivity, this G-FET was also modified with a ganglioside GM1-enriched SLB (GM1-SLB/G-FET) to detect cholera toxin B.	Gangliosides	250-261	intraflagellar transport 172	Homo sapiens	280-293
29282205-7	2018	AUTS2 in turn binds and activates the promoter of the first and rate-limiting ganglioside-producing enzyme GM3 synthase, thus fostering the synthesis of gangliosides.	Gangliosides	153-165	activator of transcription and developmental regulator AUTS2	Homo sapiens	0-5
29282205-7	2018	AUTS2 in turn binds and activates the promoter of the first and rate-limiting ganglioside-producing enzyme GM3 synthase, thus fostering the synthesis of gangliosides.	Gangliosides	153-165	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	107-119
29844873-0	2018	Synergistic potentiation of the anti-metastatic effect of anti EGFR mAb by its combination with immunotherapies targeting the ganglioside NGcGM3.	Gangliosides	126-137	epidermal growth factor receptor	Homo sapiens	63-67
29844873-6	2018	We hypothesized that enrichment of NGcGM3 expression in tumors relates to advantages of this ganglioside, on ensuring both EGFR and uPAR pathways optimal function.	Gangliosides	93-104	epidermal growth factor receptor	Homo sapiens	123-127
29844873-6	2018	We hypothesized that enrichment of NGcGM3 expression in tumors relates to advantages of this ganglioside, on ensuring both EGFR and uPAR pathways optimal function.	Gangliosides	93-104	plasminogen activator, urokinase receptor	Homo sapiens	132-136
29698439-0	2018	TNF differentially regulates ganglioside biosynthesis and expression in breast cancer cell lines.	Gangliosides	29-40	tumor necrosis factor	Homo sapiens	0-3
29698439-2	2018	Mainly restricted to the nervous system in healthy adult, complex gangliosides such as GD3 and GD2 have been shown to be involved in aggressiveness and metastasis of neuro-ectoderm derived tumors such as melanoma and neuroblastoma.	Gangliosides	66-78	GRDX	Homo sapiens	87-90
29698439-3	2018	GD3 synthase (GD3S), the key enzyme that controls the biosynthesis of complex gangliosides, was shown to be over-expressed in Estrogen Receptor (ER)-negative breast cancer tumors, and associated with a decreased overall survival of patients.	Gangliosides	78-90	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	0-12
29698439-3	2018	GD3 synthase (GD3S), the key enzyme that controls the biosynthesis of complex gangliosides, was shown to be over-expressed in Estrogen Receptor (ER)-negative breast cancer tumors, and associated with a decreased overall survival of patients.	Gangliosides	78-90	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	14-18
29698439-3	2018	GD3 synthase (GD3S), the key enzyme that controls the biosynthesis of complex gangliosides, was shown to be over-expressed in Estrogen Receptor (ER)-negative breast cancer tumors, and associated with a decreased overall survival of patients.	Gangliosides	78-90	estrogen receptor 1	Homo sapiens	126-143
29698439-6	2018	In this study, we analyzed the effect of TNF on ganglioside biosynthesis and expression in breast cancer cells from different molecular subtypes.	Gangliosides	48-59	tumor necrosis factor	Homo sapiens	41-44
29698439-8	2018	We also showed that TNF induced an increased expression of complex gangliosides at the cell surface of a small proportion of MCF-7 cells.	Gangliosides	67-79	tumor necrosis factor	Homo sapiens	20-23
29698439-9	2018	These results demonstrate that TNF differentially regulates gangliosides expression in breast cancer cell lines and establish a possible link between inflammation at the tumor site environment, expression of complex gangliosides and tumor development.	Gangliosides	60-72	tumor necrosis factor	Homo sapiens	31-34
29698439-9	2018	These results demonstrate that TNF differentially regulates gangliosides expression in breast cancer cell lines and establish a possible link between inflammation at the tumor site environment, expression of complex gangliosides and tumor development.	Gangliosides	216-228	tumor necrosis factor	Homo sapiens	31-34
29524645-3	2018	In a previous study, we showed that DRM-derived NAP-22 binds ganglioside and the inhibitory effect of ganglioside to calcineurin (CaN), a neuron-enriched calmodulin-regulated phosphoprotein phosphatase.	Gangliosides	61-72	brain abundant membrane attached signal protein 1	Homo sapiens	48-54
29524645-3	2018	In a previous study, we showed that DRM-derived NAP-22 binds ganglioside and the inhibitory effect of ganglioside to calcineurin (CaN), a neuron-enriched calmodulin-regulated phosphoprotein phosphatase.	Gangliosides	102-113	brain abundant membrane attached signal protein 1	Homo sapiens	48-54
29282205-7	2018	AUTS2 in turn binds and activates the promoter of the first and rate-limiting ganglioside-producing enzyme GM3 synthase, thus fostering the synthesis of gangliosides.	Gangliosides	78-89	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	107-119
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	Gangliosides	15-26	mitogen-activated protein kinase 8	Mus musculus	144-148
29436609-0	2018	Enhancement of malignant properties of human glioma cells by ganglioside GD3/GD2.	Gangliosides	61-72	GRDX	Homo sapiens	73-76
29436609-2	2018	In particular, gangliosides GD3 and GD2 are expressed in human gliomas.	Gangliosides	15-27	GRDX	Homo sapiens	28-31
29378245-4	2018	The analysis of mitochondrial raft-like microdomains revealed that, following MPP+ treatment, NGB translocated to raft fractions (Triton X-100-insoluble), where it interacts with ganglioside GD3.	Gangliosides	179-190	neuroglobin	Homo sapiens	94-97
29378245-4	2018	The analysis of mitochondrial raft-like microdomains revealed that, following MPP+ treatment, NGB translocated to raft fractions (Triton X-100-insoluble), where it interacts with ganglioside GD3.	Gangliosides	179-190	GRDX	Homo sapiens	191-194
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	Gangliosides	15-26	v-raf-leukemia viral oncogene 1	Mus musculus	120-125
29402391-3	2018	Thus we wondered whether IFN-gamma would counteract tumor ganglioside-mediated immune suppression.	Gangliosides	58-69	interferon gamma	Homo sapiens	25-34
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	Gangliosides	15-26	mitogen-activated protein kinase kinase 1	Mus musculus	126-132
30460093-12	2018	Therefore, the ganglioside GM1 appears to play a major role in the inflammatory response in xenotransplantation via the Raf-1/MEK1/2/ERK1/2 and JNK1/2 pathways.	Gangliosides	15-26	mitogen-activated protein kinase 3	Mus musculus	133-139
29644924-4	2018	Then, we analyzed the association of PrPC with gangliosides and EGF receptor (EGF-R) during neuronal differentiation process.	Gangliosides	47-59	prion protein	Homo sapiens	37-41
29500369-8	2018	Changes in sialylation entailed enhanced expression of the ganglioside GD3 in the treated cells.	Gangliosides	59-70	GRDX	Homo sapiens	71-74
29402391-5	2018	DC ganglioside exposure decreased TLR-dependent p38 signaling, explaining the previously observed ganglioside-induced down-modulation of pro-inflammatory surface markers and cytokines.	Gangliosides	3-14	mitogen-activated protein kinase 14	Homo sapiens	48-51
29428576-0	2018	Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway.	Gangliosides	0-11	AKT serine/threonine kinase 1	Rattus norvegicus	145-148
29428576-0	2018	Ganglioside GM1 protects against high altitude cerebral edema in rats by suppressing the oxidative stress and inflammatory response via the PI3K/AKT-Nrf2 pathway.	Gangliosides	0-11	NFE2 like bZIP transcription factor 2	Rattus norvegicus	149-153
29140753-6	2018	Our vaccine candidate was the BoNT/A heavy chain C-terminal region (HCR) that contained the point mutation BA15 (R1269A) within the ganglioside-binding site.	Gangliosides	132-143	coiled-coil alpha-helical rod protein 1	Mus musculus	68-71
29440574-5	2018	Here, we show that nonactivated CD4+ T lymphocytes can be turned into Shigella-targetable cells upon loading of their plasma membrane with sialylated glycosphingolipids (also termed gangliosides).	Gangliosides	182-194	CD4 molecule	Homo sapiens	32-35
29440574-7	2018	We demonstrate that gangliosides interact with the O-antigen polysaccharide moiety of lipopolysaccharide (LPS), the major bacterial surface antigen, thus promoting Shigella binding to CD4+ T cells.	Gangliosides	20-32	CD4 molecule	Homo sapiens	184-187
29440574-12	2018	Taking advantage of the observation that human-activated CD4+ T lymphocytes, but not nonactivated cells, are targets of Shigella, we succeeded in rendering the refractory cells susceptible to targeting upon loading of their plasma membrane with sialylated glycosphingolipids (gangliosides) that are abundantly present on activated cells.	Gangliosides	276-288	CD4 molecule	Homo sapiens	57-60
29432441-9	2018	In conclusion, this study indicates FAS-FASL promoter SNPs may promote the production of cross-reactive anti-ganglioside antibodies in GBS.	Gangliosides	109-120	Fas ligand	Homo sapiens	40-44
29432456-2	2018	We have recently shown that in addition to the previously described binding partner ganglioside GM1, CTB binds to fucosylated proteins.	Gangliosides	84-95	coenzyme Q10A	Mus musculus	96-99
29432456-2	2018	We have recently shown that in addition to the previously described binding partner ganglioside GM1, CTB binds to fucosylated proteins.	Gangliosides	84-95	phosphate cytidylyltransferase 1B, choline	Homo sapiens	101-104
29298689-8	2018	The ability of ganglioside GD2 CAR-T cells to kill ganglioside GD2+ melanoma cells was evaluated in vitro and in a patient-derived xenograft (PDX) model.	Gangliosides	15-26	nuclear receptor subfamily 1 group I member 3	Homo sapiens	31-34
29311330-4	2018	Since glucocerebrosidase 1 (GBA1) deficiency contributes to the aggregation of alpha-syn and leads to changes in neuronal glycosphingolipids (GSLs) including gangliosides, we hypothesized that GBA1 deficiency may affect the formation of alpha-syn tetramers.	Gangliosides	158-170	glucosylceramidase beta	Homo sapiens	28-32
29298689-8	2018	The ability of ganglioside GD2 CAR-T cells to kill ganglioside GD2+ melanoma cells was evaluated in vitro and in a patient-derived xenograft (PDX) model.	Gangliosides	51-62	nuclear receptor subfamily 1 group I member 3	Homo sapiens	31-34
29298689-12	2018	In addition, the GD2.BBzeta CAR-T cells demonstrated specific lysis of ganglioside GD2-expressing melanoma cells in vitro.	Gangliosides	71-82	nuclear receptor subfamily 1 group I member 3	Homo sapiens	28-31
29926407-1	2018	Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including selectins and siglecs.	Gangliosides	17-29	epidermal growth factor receptor	Homo sapiens	133-137
29306438-9	2018	Furthermore, they show that gangliosides continually move in and out of rafts that contain CD59 in an extremely dynamic manner, with much higher frequency than expected previously.	Gangliosides	28-40	CD59 molecule (CD59 blood group)	Homo sapiens	91-95
30484243-4	2018	We performed single fluorescent-molecule imaging and revealed that ganglioside probes dynamically enter and exit rafts containing CD59, a glycosylphosphatidylinositol (GPI)-anchored protein, both before and after stimulation.	Gangliosides	67-78	CD59 molecule (CD59 blood group)	Homo sapiens	130-134
30484243-5	2018	The residency time of our ganglioside probes in CD59 oligomers was 48 ms after stimulation.	Gangliosides	26-37	CD59 molecule (CD59 blood group)	Homo sapiens	48-52
30484243-8	2018	Furthermore, they demonstrate that gangliosides continually move in and out of rafts that contain CD59 in an extremely dynamic manner and at a much higher frequency than expected.	Gangliosides	35-47	CD59 molecule (CD59 blood group)	Homo sapiens	98-102
28708322-0	2018	Ganglioside GM3 suppresses lipopolysaccharide-induced inflammatory responses in rAW 264.7 macrophage cells through NF-kappaB, AP-1, and MAPKs signaling.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
29926407-1	2018	Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including selectins and siglecs.	Gangliosides	17-29	hepatocyte growth factor	Homo sapiens	145-148
29926407-1	2018	Tumor-associated gangliosides play important roles in regulation of signal transduction induced by growth-factor receptors including EGFR, FGFR, HGF and PDGFR in a specific microdomain called glycosynapse in the cancer cell membranes, and in interaction with glycan recognition molecules involved in cell adhesion and immune regulation including selectins and siglecs.	Gangliosides	17-29	platelet derived growth factor receptor beta	Homo sapiens	153-158
28796418-2	2017	The molecular mechanism by which GM1 is involved in the neurodifferentiation process is still unknown, however, in vitro and in vivo evidences have suggested that the oligosaccharide portion of this ganglioside could be involved.	Gangliosides	199-210	coenzyme Q10A	Mus musculus	33-36
29747812-8	2018	In this chapter, the focus is on mammalian sialidases preferentially hydrolyzing gangliosides, mostly Neu3 and Neu4, with an attempt to provide a brief overview of their physiological and pathological roles.	Gangliosides	81-93	neuraminidase 3	Homo sapiens	102-106
29747812-8	2018	In this chapter, the focus is on mammalian sialidases preferentially hydrolyzing gangliosides, mostly Neu3 and Neu4, with an attempt to provide a brief overview of their physiological and pathological roles.	Gangliosides	81-93	neuraminidase 4	Homo sapiens	111-115
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	146-158	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	50-62
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	146-158	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	64-68
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	146-158	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	70-77
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	146-158	granulocyte macrophage antigen 3	Mus musculus	50-53
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	277-289	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	50-62
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	277-289	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	64-68
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	277-289	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	70-77
29747813-1	2018	Since the successful molecular cloning in 1998 of GM3 synthase (GM3S, ST3GAL5), the enzyme responsible for initiating biosynthesis of all complex gangliosides, the efforts of our research group have been focused on clarifying the physiological and pathological implications of gangliosides, particularly GM3.	Gangliosides	277-289	granulocyte macrophage antigen 3	Mus musculus	50-53
29747813-3	2018	Our studies of the molecular pathogenesis of type 2 diabetes, focused on interaction between insulin receptor and GM3 in membrane microdomains, led to a novel concept: type 2 diabetes and certain other lifestyle-related diseases are membrane microdomain disorders resulting from aberrant expression of gangliosides.	Gangliosides	302-314	granulocyte macrophage antigen 3	Mus musculus	114-117
28894900-8	2017	Therefore, the interaction of ganglioside-containing membrane with LHRH might be crucial in aiding the LHRH to translate through the neural membrane and reach its receptor for binding and activation.	Gangliosides	30-41	gonadotropin releasing hormone 1	Homo sapiens	67-71
28894900-8	2017	Therefore, the interaction of ganglioside-containing membrane with LHRH might be crucial in aiding the LHRH to translate through the neural membrane and reach its receptor for binding and activation.	Gangliosides	30-41	gonadotropin releasing hormone 1	Homo sapiens	103-107
29747815-5	2018	Ganglioside GM3, a sialylated epidermal glycosphingolipid, has been identified as a key mediator of the inhibition of insulin/IGF-1 signaling in response to factors, such as tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
29747815-5	2018	Ganglioside GM3, a sialylated epidermal glycosphingolipid, has been identified as a key mediator of the inhibition of insulin/IGF-1 signaling in response to factors, such as tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia.	Gangliosides	0-11	insulin-like growth factor 1	Mus musculus	126-131
29747815-5	2018	Ganglioside GM3, a sialylated epidermal glycosphingolipid, has been identified as a key mediator of the inhibition of insulin/IGF-1 signaling in response to factors, such as tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia.	Gangliosides	0-11	tumor necrosis factor	Mus musculus	174-201
29747815-5	2018	Ganglioside GM3, a sialylated epidermal glycosphingolipid, has been identified as a key mediator of the inhibition of insulin/IGF-1 signaling in response to factors, such as tumor necrosis factor-alpha (TNF-alpha) and hyperglycemia.	Gangliosides	0-11	tumor necrosis factor	Mus musculus	203-212
29747816-6	2018	We found that GD3 is the predominant ganglioside species in NSCs (>80%) and modulates NSC proliferation by interacting with epidermal growth factor receptor signaling.	Gangliosides	37-48	GRDX	Homo sapiens	14-17
29747816-9	2018	The synthesis of GD3 is switched to the synthesis of complex, brain-type gangliosides, namely, GM1, GD1a, GD1b, and GT1b, resulting in terminal differentiation and loss of "stemness" of NSCs.	Gangliosides	73-85	GRDX	Homo sapiens	17-20
29747822-0	2018	Ganglioside-Mediated Assembly of Amyloid beta-Protein: Roles in Alzheimer"s Disease.	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	33-45
29747822-3	2018	In 1995, ganglioside-bound Abeta (GAbeta), with unique molecular characteristics, including its altered immunoreactivity and its conspicuous ability to accelerate Abeta assembly, was discovered in an autopsied brain showing early pathological changes of AD.	Gangliosides	9-20	alpha glucosidase	Homo sapiens	34-40
29747822-3	2018	In 1995, ganglioside-bound Abeta (GAbeta), with unique molecular characteristics, including its altered immunoreactivity and its conspicuous ability to accelerate Abeta assembly, was discovered in an autopsied brain showing early pathological changes of AD.	Gangliosides	9-20	amyloid beta precursor protein	Homo sapiens	27-32
29747822-6	2018	First, the conformational changes of Abeta from a random coil to an alpha-helix, and then to a beta-sheet in the presence of ganglioside were validated by several techniques.	Gangliosides	125-136	amyloid beta precursor protein	Homo sapiens	37-42
29747822-8	2018	Third, it was found that the Abeta binding to ganglioside to form GAbeta occurs under limited conditions, which were provided by the lipid environment surrounding ganglioside.	Gangliosides	46-57	amyloid beta precursor protein	Homo sapiens	29-34
29747822-8	2018	Third, it was found that the Abeta binding to ganglioside to form GAbeta occurs under limited conditions, which were provided by the lipid environment surrounding ganglioside.	Gangliosides	46-57	alpha glucosidase	Homo sapiens	66-72
29747822-8	2018	Third, it was found that the Abeta binding to ganglioside to form GAbeta occurs under limited conditions, which were provided by the lipid environment surrounding ganglioside.	Gangliosides	163-174	amyloid beta precursor protein	Homo sapiens	29-34
29747822-8	2018	Third, it was found that the Abeta binding to ganglioside to form GAbeta occurs under limited conditions, which were provided by the lipid environment surrounding ganglioside.	Gangliosides	163-174	alpha glucosidase	Homo sapiens	66-72
29747822-10	2018	In this chapter, further progress of the study of ganglioside-mediated Abeta assembly, especially from the aspects of physicochemistry, structural biology, and neuropathology, is reviewed.	Gangliosides	50-61	amyloid beta precursor protein	Homo sapiens	71-76
29747823-1	2018	This review addresses the role of alpha-synuclein (alphaSyn) in the etiopathology of Parkinson"s disease (PD), with emphasis on its interaction with GM1 ganglioside.	Gangliosides	153-164	synuclein, alpha	Mus musculus	34-49
29747823-1	2018	This review addresses the role of alpha-synuclein (alphaSyn) in the etiopathology of Parkinson"s disease (PD), with emphasis on its interaction with GM1 ganglioside.	Gangliosides	153-164	synuclein, alpha	Mus musculus	51-59
29747823-1	2018	This review addresses the role of alpha-synuclein (alphaSyn) in the etiopathology of Parkinson"s disease (PD), with emphasis on its interaction with GM1 ganglioside.	Gangliosides	153-164	coenzyme Q10A	Mus musculus	149-152
29747823-6	2018	The consequences of insufficient GM1 are illustrated in a newly presented mouse model of PD based on partial deletion of this ganglioside due to heterologous disruption of B4galnt1 (GM2/GD2 synthase), such mice presenting accurate recapitulation of the PD phenotype.	Gangliosides	126-137	coenzyme Q10A	Mus musculus	33-36
29464018-0	2018	Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFalpha.	Gangliosides	0-11	insulin	Homo sapiens	73-80
29464018-0	2018	Ganglioside GM1 contributes to extracellular/intracellular regulation of insulin resistance, impairment of insulin signaling and down-stream eNOS activation, in human aortic endothelial cells after short- or long-term exposure to TNFalpha.	Gangliosides	0-11	tumor necrosis factor	Homo sapiens	230-238
29464018-6	2018	We show that ganglioside GM1 levels on cell membranes change depending on time of exposure to TNFalpha and its concentration and that the GM1 expression is associated with specific extracellular/intracellular regulation of the insulin signaling cascade.	Gangliosides	13-24	eiger	Drosophila melanogaster	94-102
29464018-6	2018	We show that ganglioside GM1 levels on cell membranes change depending on time of exposure to TNFalpha and its concentration and that the GM1 expression is associated with specific extracellular/intracellular regulation of the insulin signaling cascade.	Gangliosides	13-24	Insulin-like receptor	Drosophila melanogaster	227-234
29148800-4	2017	Ganglioside nanoclusters were constructed as ternary mixed lipid bilayers composed of ganglioside (GM1, GM2, GM3, GD1a, or GT1b), sphingomyelin, and cholesterol, and their surface topography was visualized by atomic force microscopy.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	109-112
29272022-0	2017	Effects of gangliosides on expressions of caspase-3 and NGF in rats with acute spinal cord injury.	Gangliosides	11-23	caspase 3	Rattus norvegicus	42-51
29272022-0	2017	Effects of gangliosides on expressions of caspase-3 and NGF in rats with acute spinal cord injury.	Gangliosides	11-23	nerve growth factor	Rattus norvegicus	56-59
29272022-1	2017	OBJECTIVE: To investigate the effects of ganglioside [monostalotetra-hexosylganglioside (GM1)] on the expressions of caspase-3 and nerve growth factor (NGF) in rats with acute spinal cord injury (SCI).	Gangliosides	41-52	caspase 3	Rattus norvegicus	117-126
29272022-1	2017	OBJECTIVE: To investigate the effects of ganglioside [monostalotetra-hexosylganglioside (GM1)] on the expressions of caspase-3 and nerve growth factor (NGF) in rats with acute spinal cord injury (SCI).	Gangliosides	41-52	nerve growth factor	Rattus norvegicus	131-150
29272022-1	2017	OBJECTIVE: To investigate the effects of ganglioside [monostalotetra-hexosylganglioside (GM1)] on the expressions of caspase-3 and nerve growth factor (NGF) in rats with acute spinal cord injury (SCI).	Gangliosides	41-52	nerve growth factor	Rattus norvegicus	152-155
28760640-2	2017	Focusing on this invasive nature, we investigated whether ganglioside-specific sialidase NEU3 might be involved, because gangliosides are major components of brain tissues, and cell surface sialic acids, as target residues of sialidase catalysis, are thought to be closely related to cell invasion.	Gangliosides	58-69	neuraminidase 3	Homo sapiens	89-93
28993428-2	2017	Previous studies indicated that levels of brain gangliosides are lower than normal in HD models and that administration of exogenous ganglioside GM1 corrects motor dysfunction in the YAC128 mouse model of HD In this study, we provide evidence that intraventricular administration of GM1 has profound disease-modifying effects across HD mouse models with different genetic background.	Gangliosides	48-60	coenzyme Q10A	Mus musculus	145-148
28993428-2	2017	Previous studies indicated that levels of brain gangliosides are lower than normal in HD models and that administration of exogenous ganglioside GM1 corrects motor dysfunction in the YAC128 mouse model of HD In this study, we provide evidence that intraventricular administration of GM1 has profound disease-modifying effects across HD mouse models with different genetic background.	Gangliosides	48-59	coenzyme Q10A	Mus musculus	145-148
28993428-7	2017	The widespread benefits of GM1 administration, at molecular, cellular and behavioural levels, indicate that this ganglioside has strong therapeutic and disease-modifying potential in HD.	Gangliosides	113-124	coenzyme Q10A	Mus musculus	27-30
28898517-9	2017	Binding to the SytII/ganglioside complex is functionally related to the toxic action; however, the receptor recognition sites are conserved.	Gangliosides	21-32	synaptotagmin 2	Homo sapiens	15-20
28899916-10	2017	Given the persistent presence of fibronectin aggregates in MS lesions, ganglioside GD1a might act as a potential novel therapeutic tool to selectively modulate the detrimental signaling environment that precludes remyelination.SIGNIFICANCE STATEMENT As an environmental factor, aggregates of the extracellular matrix protein fibronectin perturb the maturation of oligodendrocyte progenitor cells (OPCs), thereby impeding remyelination, in the demyelinating disease multiple sclerosis (MS).	Gangliosides	71-82	fibronectin 1	Rattus norvegicus	33-44
28899916-10	2017	Given the persistent presence of fibronectin aggregates in MS lesions, ganglioside GD1a might act as a potential novel therapeutic tool to selectively modulate the detrimental signaling environment that precludes remyelination.SIGNIFICANCE STATEMENT As an environmental factor, aggregates of the extracellular matrix protein fibronectin perturb the maturation of oligodendrocyte progenitor cells (OPCs), thereby impeding remyelination, in the demyelinating disease multiple sclerosis (MS).	Gangliosides	71-82	fibronectin 1	Rattus norvegicus	325-336
28899916-4	2017	Here, we aim at elucidating whether exogenously added gangliosides (i.e., cell surface lipids with a potential to modulate signaling pathways) could counteract fibronectin-mediated inhibition of OPC maturation.	Gangliosides	54-66	fibronectin 1	Rattus norvegicus	160-171
29026192-6	2017	These UGCG-depleted cells show reduced levels of gangliosides and significantly elevated levels of rhEPO sialylation.	Gangliosides	49-61	ceramide glucosyltransferase	Cricetulus griseus	6-10
28899916-11	2017	Here we demonstrate that exogenous addition of ganglioside GD1a overcomes the inhibiting effect of aggregated fibronectin on OPC maturation, both in vitro and in vivo, by activating a PKA-dependent signaling pathway.	Gangliosides	47-58	fibronectin 1	Rattus norvegicus	110-121
28899916-11	2017	Here we demonstrate that exogenous addition of ganglioside GD1a overcomes the inhibiting effect of aggregated fibronectin on OPC maturation, both in vitro and in vivo, by activating a PKA-dependent signaling pathway.	Gangliosides	47-58	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	184-187
28734966-5	2017	Using single fluorescent-molecule imaging, we have found that ganglioside probes dynamically enter and leave rafts featuring CD59, a GPI-anchored protein.	Gangliosides	62-73	CD59 molecule (CD59 blood group)	Homo sapiens	125-129
28571946-1	2017	Severe auditory impairment observed in GM3 synthase-deficient mice and humans indicates that glycosphingolipids, especially sialic-acid containing gangliosides, are indispensable for hearing.	Gangliosides	147-159	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	39-51
28602513-4	2017	Furthermore, roles of gangliosides in neurons were demonstrated by neuron-specific transgenic of B4galnt1 with genetic background of B4galnt1 deficiency.	Gangliosides	22-34	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	97-105
28734966-7	2017	The residency time of our ganglioside probes in rafts with CD59 oligomers was 48ms, after stimulation.	Gangliosides	26-37	CD59 molecule (CD59 blood group)	Homo sapiens	59-63
28838234-5	2017	Furthermore, isomeric ganglioside species can be differentiated, and the double bond location in the ceramide moiety of the gangliosides can be identified through the MS3 approach involving sequential CID and EID processes.	Gangliosides	124-136	MS3	Homo sapiens	167-170
28415808-1	2017	We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis.	Gangliosides	28-39	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	124-136
28499815-5	2017	The addition of nanomolar concentration of TRAF2 in GUVs also seems to exert a mechanical action, as demonstrated by the formation of intraluminal vesicles, a process in which ganglioside GM1 plays a crucial role.	Gangliosides	176-187	TNF receptor associated factor 2	Homo sapiens	43-48
28377426-4	2017	The substrates of Hex A and B, gangliosides GM2 and GA2, accumulate inside the lysosomes of the CNS and in peripheral organs.	Gangliosides	31-43	hexosaminidase subunit alpha	Homo sapiens	18-29
28778444-4	2017	TNFA -238A allele was more frequent among anti-ganglioside (GM1) antibody-positive patients (P=0.0092) and -863AA associated with AMAN subtype of GBS (P=0.0398).	Gangliosides	47-58	tumor necrosis factor	Homo sapiens	0-4
28601604-3	2017	This disorder results from a mutation in the gene encoding the lysosomal sulphatase sulphamidase, and as a consequence heparan sulphate accumulates, accompanied by secondarily-stored gangliosides.	Gangliosides	183-195	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	84-96
28442546-4	2017	Inhibition of PI3K-dependent exocytosis of TRPC6 is thought to be the underlying mechanism, and recent studies showed that sKlotho interacts with alpha2-3-sialyllactose-containing gangliosides enriched in lipid rafts to inhibit raft-dependent PI3K signaling.	Gangliosides	180-192	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	43-48
28442549-0	2017	Neuraminidases 3 and 4 regulate neuronal function by catabolizing brain gangliosides.	Gangliosides	72-84	neuraminidase 3	Mus musculus	0-22
28442549-3	2017	We demonstrate that 2 mammalian enzymes, neuraminidases 3 and 4, play important roles in catabolic processing of brain gangliosides by cleaving terminal sialic acid residues in their glycan chains.	Gangliosides	119-131	neuraminidase 3	Homo sapiens	41-63
28585705-0	2017	Ganglioside GM3 induces cumulus cell apoptosis through inhibition of epidermal growth factor receptor-mediated PI3K/AKT signaling pathways during in vitro maturation of pig oocytes.	Gangliosides	0-11	Epidermal growth factor receptor	Drosophila melanogaster	69-101
28399449-2	2017	The bioactivity studies demonstrated that most of these compounds could upregulate the expression of matrix metalloproteinase-9 (MMP-9, extracellular matrix proteins associated with tumor migration) in murine melanoma B16 cells in a similar manner to the natural ganglioside monosialodihexosylganglioside (GM3), which highlights the potential use of these neoglycosphingolipids as inhibitors of tumor migration.	Gangliosides	263-274	matrix metallopeptidase 9	Mus musculus	101-127
28399449-2	2017	The bioactivity studies demonstrated that most of these compounds could upregulate the expression of matrix metalloproteinase-9 (MMP-9, extracellular matrix proteins associated with tumor migration) in murine melanoma B16 cells in a similar manner to the natural ganglioside monosialodihexosylganglioside (GM3), which highlights the potential use of these neoglycosphingolipids as inhibitors of tumor migration.	Gangliosides	263-274	matrix metallopeptidase 9	Mus musculus	129-134
28586101-3	2017	Contact-inhibited cells show increased expression of the ganglioside GD3 and the globo-series GSL Gb3, and of the mRNAs for the corresponding sialyltransferases ST8SIA1 (GD3 synthase) and galactosyltransferase A4GALT (Gb3 synthase).	Gangliosides	57-68	GRDX	Homo sapiens	69-72
28415808-1	2017	We have identified that the ganglioside GD2 is a marker for breast cancer stem cells (BCSCs), and that targeting the enzyme GD3 synthase (GD3S, which regulates GD2 biosynthesis) reduces breast tumorigenesis.	Gangliosides	28-39	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	138-142
26673692-8	2017	Ganglioside consumption increased ( P < .05) plasma content of total GD3 by 35% over 8 weeks.	Gangliosides	0-11	GRDX	Homo sapiens	72-75
28651685-1	2017	The BMB Reports would like to correct in the ACKNOWLEDGEMENTS of BMB Rep. 45(12), 713-718 titled "Ganglioside GM1 influences the proliferation rate of mouse induced pluripotent stem cells".	Gangliosides	98-109	coenzyme Q10A	Mus musculus	110-113
28286312-6	2017	The most abundant ganglioside in glioblastoma was GD3 (d18:1/18:0), followed by GD3 (d18:1/24:0) that was exclusively detected in glioblastoma tissue.	Gangliosides	18-29	GRDX	Homo sapiens	50-53
28425215-5	2017	We found that ganglioside GM1 movement was exclusively reduced in BALB/c compared with C57BL/6 among other examined sperm maturation parameters, such as GPI-AP release, sperm migration to the oviduct, cholesterol efflux, protein tyrosine phosphorylation and acrosome reaction, and was strongly linked to sperm fertility phenotype.	Gangliosides	14-25	coenzyme Q10A	Mus musculus	26-29
28432329-5	2017	We then developed, using a label-free optical biosensor, a new method to determine the kinetic constants of BoNT/B holotoxin binding to its receptor synaptotagmin2/GT1b ganglioside (kon = 2.3 x105 M-1.s-1, koff = 1.3 10-4 s-1), yielding an affinity constant (KD = 0.6 nM) similar to values determined from native tissue.	Gangliosides	169-180	synaptotagmin 2	Homo sapiens	149-163
28275055-0	2017	Altered expression of ganglioside GM3 molecular species and a potential regulatory role during myoblast differentiation.	Gangliosides	22-33	granulocyte macrophage antigen 3	Mus musculus	34-37
28275055-6	2017	Here we describe striking changes in quantity and quality of gangliosides (particularly GM3) during differentiation of mouse C2C12 myoblast cells and key roles played by distinct GM3 molecular species at each step of the process.	Gangliosides	61-73	granulocyte macrophage antigen 3	Mus musculus	88-91
27610460-7	2017	For protein-ganglioside interactions, in the atomistic simulations, GM1 lipids bind to specific sites on the AQP1 surface, whereas they are depleted from WALP23.	Gangliosides	12-23	aquaporin 1 (Colton blood group)	Homo sapiens	109-113
27984697-8	2017	Subsequent multivariate statistical analysis of the spectral data revealed significant localization of gangliosides and ceramides species to Abeta positive plaques, which was accompanied by distinct local reduction of sulfatides.	Gangliosides	103-115	amyloid beta (A4) precursor protein	Mus musculus	141-146
28082351-5	2017	In agreement with this finding, FTY720 pretreatment of human NPC1 mutant fibroblasts restored transport of the cholera toxin B subunit, which binds ganglioside GM1, to the Golgi apparatus.	Gangliosides	148-159	NPC intracellular cholesterol transporter 1	Homo sapiens	61-65
28252046-5	2017	GM3, which is a precursor molecule for most gangliosides, was transiently expressed in surrounding damaged tissue, and depletion of GM3 synthase enhanced cartilage repair.	Gangliosides	44-56	granulocyte macrophage antigen 3	Mus musculus	0-3
28367091-10	2017	In addition, the composition of total gangliosides was changed between control (pc3) and pc3-GD3s cells, as confirmed by HPTLC.	Gangliosides	38-50	proprotein convertase subtilisin/kexin type 1	Homo sapiens	80-83
27923633-2	2017	On the cellular level NPC1 mutations lead to an accumulation of cholesterol and gangliosides.	Gangliosides	80-92	NPC intracellular cholesterol transporter 1	Homo sapiens	22-26
28367091-10	2017	In addition, the composition of total gangliosides was changed between control (pc3) and pc3-GD3s cells, as confirmed by HPTLC.	Gangliosides	38-50	proprotein convertase subtilisin/kexin type 1	Homo sapiens	89-92
27999993-4	2017	In addition, myelination is also highly dependent on glycans, and the stabilization of myelin architecture requires the interaction of the myelin-associated glycoprotein (siglec-4) with gangliosides in the axonal membrane.	Gangliosides	186-198	myelin associated glycoprotein	Homo sapiens	139-169
27729281-2	2017	GM3, a lipid raft ganglioside synthesized by GM3 synthase (GM3S), regulates receptor signaling.	Gangliosides	18-29	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	45-57
27939129-5	2017	Infected NOD WT and NOD IL-10-/- mice also produced anti-ganglioside antibodies of the IgG1 isotype directed against a mixture of GM1/GQ1b gangliosides.	Gangliosides	57-68	interleukin 10	Mus musculus	24-29
27939129-5	2017	Infected NOD WT and NOD IL-10-/- mice also produced anti-ganglioside antibodies of the IgG1 isotype directed against a mixture of GM1/GQ1b gangliosides.	Gangliosides	57-68	LOC105243590	Mus musculus	87-91
27939129-5	2017	Infected NOD WT and NOD IL-10-/- mice also produced anti-ganglioside antibodies of the IgG1 isotype directed against a mixture of GM1/GQ1b gangliosides.	Gangliosides	57-68	coenzyme Q10A	Mus musculus	130-138
27939129-5	2017	Infected NOD WT and NOD IL-10-/- mice also produced anti-ganglioside antibodies of the IgG1 isotype directed against a mixture of GM1/GQ1b gangliosides.	Gangliosides	139-151	interleukin 10	Mus musculus	24-29
27939129-5	2017	Infected NOD WT and NOD IL-10-/- mice also produced anti-ganglioside antibodies of the IgG1 isotype directed against a mixture of GM1/GQ1b gangliosides.	Gangliosides	139-151	LOC105243590	Mus musculus	87-91
27729281-0	2017	Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
27729281-0	2017	Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility.	Gangliosides	0-11	insulin like growth factor 1	Homo sapiens	56-61
27729281-2	2017	GM3, a lipid raft ganglioside synthesized by GM3 synthase (GM3S), regulates receptor signaling.	Gangliosides	18-29	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	59-63
27729281-0	2017	Ganglioside GM3 Mediates Glucose-Induced Suppression of IGF-1 Receptor-Rac1 Activation to Inhibit Keratinocyte Motility.	Gangliosides	0-11	Rac family small GTPase 1	Homo sapiens	71-75
27729281-2	2017	GM3, a lipid raft ganglioside synthesized by GM3 synthase (GM3S), regulates receptor signaling.	Gangliosides	18-29	granulocyte macrophage antigen 3	Mus musculus	0-3
28032600-3	2017	Here, we showed that ganglioside GM1 highly induced the activity and expression of arginase-1 (Arg-1), a major M2 macrophage marker, compared to various gangliosides in bone marrow-derived macrophages (BMDM), peritoneal macrophages and Raw264.7 macrophage cells.	Gangliosides	21-32	arginase, liver	Mus musculus	95-100
28129379-5	2017	Particles were captured by Siglec-1, a prominent cell surface lectin that attaches to gangliosides on the lipid envelope of the virus.	Gangliosides	86-98	sialic acid binding Ig like lectin 1	Homo sapiens	27-35
28032600-3	2017	Here, we showed that ganglioside GM1 highly induced the activity and expression of arginase-1 (Arg-1), a major M2 macrophage marker, compared to various gangliosides in bone marrow-derived macrophages (BMDM), peritoneal macrophages and Raw264.7 macrophage cells.	Gangliosides	21-32	coenzyme Q10A	Mus musculus	33-36
28032600-3	2017	Here, we showed that ganglioside GM1 highly induced the activity and expression of arginase-1 (Arg-1), a major M2 macrophage marker, compared to various gangliosides in bone marrow-derived macrophages (BMDM), peritoneal macrophages and Raw264.7 macrophage cells.	Gangliosides	21-32	arginase, liver	Mus musculus	83-93
28069944-7	2017	To explain why klotho preferentially targets lipid rafts we show that clustering of gangliosides in lipid rafts is important.	Gangliosides	84-96	klotho	Mus musculus	15-21
28069944-9	2017	Our results identify ganglioside-enriched lipid rafts to be receptors that mediate soluble klotho regulation of PI3K signaling.	Gangliosides	21-32	klotho	Mus musculus	91-97
27909553-0	2016	Effects of gangliosides from deer bone extract on the gene expressions of matrix metalloproteinases and collagen type II in interleukin-1beta-induced osteoarthritic chondrocytes.	Gangliosides	11-23	interleukin-1 beta	Oryctolagus cuniculus	124-141
27683310-2	2017	ST3Gal-II (coded by the St3gal2 gene) transfers sialic acid preferentially to the three positions of galactose on the Galbeta1-3GalNAc terminus of gangliosides GM1 and GD1b to synthesize GD1a and GT1b, respectively.	Gangliosides	147-159	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	0-9
27683310-2	2017	ST3Gal-II (coded by the St3gal2 gene) transfers sialic acid preferentially to the three positions of galactose on the Galbeta1-3GalNAc terminus of gangliosides GM1 and GD1b to synthesize GD1a and GT1b, respectively.	Gangliosides	147-159	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	24-31
27683310-8	2017	Thin-layer chromatography and mass spectrometry revealed altered ganglioside profiles in the adipose tissue of St3gal2-null mice compared to WT littermates.	Gangliosides	65-76	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	111-118
27683310-11	2017	We conclude that altered ganglioside expression in adipose tissue results in diminished IR sensitivity and late-onset obesity.	Gangliosides	25-36	insulin receptor	Mus musculus	88-90
27720939-4	2016	Reduction of Neu1 expression has been previously observed in the cerebellum of MPS I mice; to be active, neuraminidase 1 forms the lysosomal multienzyme complex (LMC) with two other proteins, beta-galactosidase and protective protein/cathepsin A, involved in stepwise degradation of gangliosides in the lysosomes.	Gangliosides	283-295	neuraminidase 1	Mus musculus	13-17
27720939-4	2016	Reduction of Neu1 expression has been previously observed in the cerebellum of MPS I mice; to be active, neuraminidase 1 forms the lysosomal multienzyme complex (LMC) with two other proteins, beta-galactosidase and protective protein/cathepsin A, involved in stepwise degradation of gangliosides in the lysosomes.	Gangliosides	283-295	neuraminidase 1	Mus musculus	105-120
27922006-2	2016	MAG maintains the myelin-axon spacing by interacting with specific neuronal glycolipids (gangliosides), inhibits axon regeneration and controls myelin formation.	Gangliosides	89-101	myelin associated glycoprotein	Homo sapiens	0-3
27922006-5	2016	MAG-oligosaccharide complex structures and biophysical assays show how MAG engages axonal gangliosides at domain Ig1.	Gangliosides	90-102	myelin associated glycoprotein	Homo sapiens	0-3
27922006-5	2016	MAG-oligosaccharide complex structures and biophysical assays show how MAG engages axonal gangliosides at domain Ig1.	Gangliosides	90-102	myelin associated glycoprotein	Homo sapiens	71-74
27940403-1	2017	BACKGROUND AND AIMS: Plasma sphingolipids including ceramides, and gangliosides are associated with insulin resistance (IR) through effects on insulin signalling and glucose metabolism.	Gangliosides	67-79	insulin	Homo sapiens	100-107
27940403-1	2017	BACKGROUND AND AIMS: Plasma sphingolipids including ceramides, and gangliosides are associated with insulin resistance (IR) through effects on insulin signalling and glucose metabolism.	Gangliosides	67-79	insulin	Homo sapiens	143-150
27933798-3	2016	The physiological role of the Abeta interaction with the ganglioside GM1 is still unclear.	Gangliosides	57-68	amyloid beta precursor protein	Homo sapiens	30-35
27644882-0	2016	Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.	Gangliosides	19-31	leptin	Mus musculus	52-58
28197367-3	2017	Expression of CARs directed against the ganglioside antigen GD2 in activated NK cells increased their responses to GD2+ allogeneic EwS cells in vitro and overcame resistance of individual cell lines to NK cell lysis.	Gangliosides	40-51	EWS RNA binding protein 1	Homo sapiens	131-134
27644882-0	2016	Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.	Gangliosides	19-31	leptin receptor	Mus musculus	59-70
27644882-0	2016	Increased a-series gangliosides positively regulate leptin/Ob receptor-mediated signals in hypothalamus of GD3 synthase-deficient mice.	Gangliosides	19-31	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	107-119
27644882-3	2016	In GD3 synthase-knockout (GD3S KO) mice, deletion of b-series gangliosides resulted in the reduction of serum leptin due to disturbed secretion from adipocytes.	Gangliosides	62-74	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	3-15
27644882-3	2016	In GD3 synthase-knockout (GD3S KO) mice, deletion of b-series gangliosides resulted in the reduction of serum leptin due to disturbed secretion from adipocytes.	Gangliosides	62-74	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	26-30
27644882-3	2016	In GD3 synthase-knockout (GD3S KO) mice, deletion of b-series gangliosides resulted in the reduction of serum leptin due to disturbed secretion from adipocytes.	Gangliosides	62-74	leptin	Mus musculus	110-116
27644882-6	2016	Leptin stimulation of hypothalamus-derived N-41 cells and their transfectants with GD3S cDNA showed that a-series gangliosides positively regulate leptin/ObR-mediated signals.	Gangliosides	114-126	leptin	Mus musculus	0-6
27644882-6	2016	Leptin stimulation of hypothalamus-derived N-41 cells and their transfectants with GD3S cDNA showed that a-series gangliosides positively regulate leptin/ObR-mediated signals.	Gangliosides	114-126	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	83-87
27644882-6	2016	Leptin stimulation of hypothalamus-derived N-41 cells and their transfectants with GD3S cDNA showed that a-series gangliosides positively regulate leptin/ObR-mediated signals.	Gangliosides	114-126	leptin	Mus musculus	147-153
27644882-6	2016	Leptin stimulation of hypothalamus-derived N-41 cells and their transfectants with GD3S cDNA showed that a-series gangliosides positively regulate leptin/ObR-mediated signals.	Gangliosides	114-126	leptin receptor	Mus musculus	154-157
27644882-7	2016	Co-precipitation analysis revealed that ObR interacts with a-series gangliosides with increased association by leptin stimulation.	Gangliosides	68-80	leptin receptor	Mus musculus	40-43
27644882-7	2016	Co-precipitation analysis revealed that ObR interacts with a-series gangliosides with increased association by leptin stimulation.	Gangliosides	68-80	leptin	Mus musculus	111-117
27486266-10	2016	Interaction of SVS2 and spermatozoa is mediated by the ganglioside GM1 in the sperm membrane; however, both SVS3 and SVS4 had weaker affinities for GM1 than SVS2.	Gangliosides	55-66	semenogelin 1	Mus musculus	15-19
27591028-1	2016	The most abundant ganglioside group in both human milk and bovine milk during the first postnatal week is ganglioside GD3.	Gangliosides	18-29	GRDX	Homo sapiens	118-121
27591028-1	2016	The most abundant ganglioside group in both human milk and bovine milk during the first postnatal week is ganglioside GD3.	Gangliosides	106-117	GRDX	Homo sapiens	118-121
27766070-3	2016	In the present study, besides the purpose of further confirming the evidence of perturbed metabolism of gangliosides GM1, GD1a, and GT1b the most abundant cerebral glycosphingolipids, in the striatal and cortical tissues of HD transgenic mice, we aimed to test the hypothesis that abnormal levels of these lipids may be found also in the corpus callosum white matter, a ganglioside-enriched brain region described being dysfunctional early in the disease.	Gangliosides	104-116	coenzyme Q10A	Mus musculus	117-120
27766070-3	2016	In the present study, besides the purpose of further confirming the evidence of perturbed metabolism of gangliosides GM1, GD1a, and GT1b the most abundant cerebral glycosphingolipids, in the striatal and cortical tissues of HD transgenic mice, we aimed to test the hypothesis that abnormal levels of these lipids may be found also in the corpus callosum white matter, a ganglioside-enriched brain region described being dysfunctional early in the disease.	Gangliosides	104-115	coenzyme Q10A	Mus musculus	117-120
27766070-4	2016	Semi-quantitative analysis of GM1, GD1a, and GT1b content indicated that ganglioside metabolism is a common feature in two different HD animal models (YAC128 and R6/2 mice) and importantly, demonstrated that levels of these gangliosides were significantly reduced in the corpus callosum white matter of both models starting from the early stages of the disease.	Gangliosides	73-84	coenzyme Q10A	Mus musculus	30-33
27687691-0	2016	Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing.	Gangliosides	86-98	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	14-22
27687691-0	2016	Expression of B4GALNT1, an essential glycosyltransferase for the synthesis of complex gangliosides, suppresses BACE1 degradation and modulates APP processing.	Gangliosides	86-98	beta-secretase 1	Homo sapiens	111-116
27687691-5	2016	We also showed that beta-site APP cleaving enzyme 1 (BACE1) protein is highly protected from the degradation in cells expressing these gangliosides, thereby increasing the expression of this protein.	Gangliosides	135-147	beta-secretase 1	Homo sapiens	20-51
27687691-5	2016	We also showed that beta-site APP cleaving enzyme 1 (BACE1) protein is highly protected from the degradation in cells expressing these gangliosides, thereby increasing the expression of this protein.	Gangliosides	135-147	beta-secretase 1	Homo sapiens	53-58
27687691-8	2016	Based on the current results, we propose a hitherto undisclosed link between ganglioside expression and AD; the expression of B4GALNT1 positively regulates the beta-site cleavage by mainly inhibiting the lysosomal degradation of BACE1 protein.	Gangliosides	77-88	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	126-134
26374552-9	2016	Accumulating evidences indicate that the conjugation of anti-ganglioside monoclonal antibodies to activating FcgammaRIII present on the circulating macrophages inhibits axonal regeneration.	Gangliosides	61-72	Fc gamma receptor IIIa	Homo sapiens	109-120
27207911-2	2016	Monosialotetrahexosylganglioside is a crucial ganglioside for the central nervous system and has been reported to affect the function of the brain derived neurotrophic factor system.	Gangliosides	21-32	brain derived neurotrophic factor	Mus musculus	141-174
27639375-4	2016	We found that inhibition of glucosylceramide synthase (GCS), the key enzyme of ganglioside biosynthesis, increases viability of cortical neurons in 5xFAD mice, as well as in cultured neurons exposed to oligomeric amyloid-beta-derived diffusible ligands (ADDLs).	Gangliosides	79-90	UDP-glucose ceramide glucosyltransferase	Mus musculus	55-58
27639375-5	2016	We furthermore demonstrate a molecular mechanism explaining how gangliosides mediate ADDL-related toxic effects on IR of murine neurons.	Gangliosides	64-76	insulin receptor	Mus musculus	115-117
27590073-2	2016	In previous studies, we have demonstrated that ganglioside GM3 depletion by knockdown of GM3 synthase fully reverses impaired wound healing in diabetic mice.	Gangliosides	47-58	granulocyte macrophage antigen 3	Mus musculus	59-62
27590073-2	2016	In previous studies, we have demonstrated that ganglioside GM3 depletion by knockdown of GM3 synthase fully reverses impaired wound healing in diabetic mice.	Gangliosides	47-58	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	89-101
27590073-7	2016	CONCLUSIONS: These studies establish ganglioside GM3 as a new candidate responsible for neuropathic pain and small fiber neuropathy in diabetes.	Gangliosides	37-48	granulocyte macrophage antigen 3	Mus musculus	49-52
27373967-1	2016	Evidence has suggested that ganglioside abnormalities may be linked to the proteolytic processing of amyloid precursor protein (APP) in Alzheimer"s disease (AD) and that pharmacological inhibition of ganglioside synthesis may reduce amyloid beta-peptide (Abeta) production.	Gangliosides	28-39	amyloid beta precursor protein	Homo sapiens	101-126
27639375-4	2016	We found that inhibition of glucosylceramide synthase (GCS), the key enzyme of ganglioside biosynthesis, increases viability of cortical neurons in 5xFAD mice, as well as in cultured neurons exposed to oligomeric amyloid-beta-derived diffusible ligands (ADDLs).	Gangliosides	79-90	UDP-glucose ceramide glucosyltransferase	Mus musculus	28-53
27313224-11	2016	In conclusion, we show the importance of the complex N559-glycan of SV2C-LD4, adding a third anchor point beside a ganglioside and the SV2C-LD4 peptide, for BoNT/A neuronal cell surface binding and uptake.	Gangliosides	115-126	synaptic vesicle glycoprotein 2C	Homo sapiens	68-72
27251370-5	2016	These effects were accompanied by decreased level of T cell surface sialoglycosphingolipid (ganglioside) GM1 that is regulated by the endogenous neuraminidase in response to viral challenge.	Gangliosides	68-90	neuraminidase 1	Homo sapiens	145-158
27251370-5	2016	These effects were accompanied by decreased level of T cell surface sialoglycosphingolipid (ganglioside) GM1 that is regulated by the endogenous neuraminidase in response to viral challenge.	Gangliosides	92-103	neuraminidase 1	Homo sapiens	145-158
27276519-0	2016	Design, Synthesis, and Biological Evaluation of Ganglioside Hp-s1 Analogues Varying at Glucosyl Moiety.	Gangliosides	48-59	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	60-65
27276519-1	2016	Ganglioside Hp-s1 is isolated from the ovary of sea urchin Diadema setosum.	Gangliosides	0-11	HPS1 biogenesis of lysosomal organelles complex 3 subunit 1	Homo sapiens	12-17
27076627-2	2016	We have previously shown that ovarian cancers shed the ganglioside GD3, which inhibits NKT-cell activation.	Gangliosides	55-66	GRDX	Homo sapiens	67-70
27261254-5	2016	Mutations in ST3GAL5, which codes for an enzyme early in brain ganglioside biosynthesis, result in an early-onset seizure disorder with profound motor and cognitive decay, whereas mutations in B4GALNT1, a gene encoding a later step, result in hereditary spastic paraplegia accompanied by intellectual deficits.	Gangliosides	63-74	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	13-20
27261254-7	2016	Gangliosides also affect the aggregation of Abeta (Alzheimer"s disease) and alpha-synuclein (Parkinson"s Disease).	Gangliosides	0-12	synuclein alpha	Homo sapiens	76-91
27068854-0	2016	A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.	Gangliosides	155-166	BCAR1 scaffold protein, Cas family member	Homo sapiens	104-111
26960162-3	2016	Monosialotetrahexosylganglioside (GM1) is a ganglioside with wide-ranging pharmacologic effects that enhances the BDNF signaling cascade.	Gangliosides	21-32	brain derived neurotrophic factor	Mus musculus	114-118
27068854-0	2016	A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.	Gangliosides	155-166	GRDX	Homo sapiens	167-170
27068854-1	2016	We previously demonstrated that focal adhesion kinase (FAK), p130Cas and paxillin are crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	162-173	protein tyrosine kinase 2	Homo sapiens	32-53
27068854-1	2016	We previously demonstrated that focal adhesion kinase (FAK), p130Cas and paxillin are crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	162-173	protein tyrosine kinase 2	Homo sapiens	55-58
27068854-1	2016	We previously demonstrated that focal adhesion kinase (FAK), p130Cas and paxillin are crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	162-173	BCAR1 scaffold protein, Cas family member	Homo sapiens	61-68
27068854-1	2016	We previously demonstrated that focal adhesion kinase (FAK), p130Cas and paxillin are crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	162-173	GRDX	Homo sapiens	174-177
27410738-8	2016	MHC I and IL-2Ralpha/IL-15Ralpha colocalized with GM1 ganglioside-rich lipid rafts, but MHC I clusters retracted to smaller subsets of GM1- and IL-2Ralpha/IL-15Ralpha-rich areas upon knockdown.	Gangliosides	54-65	interleukin 2 receptor subunit alpha	Homo sapiens	10-20
27278006-1	2016	We have recently shown that mRNA and protein of PHLDA1 (pleckstrin-homology-like domain family A, member  1) were by far the most upregulated molecules upon treatment of IMR-32 cells with the anti-GD2 ganglioside monoclonal antibody 14G2a.	Gangliosides	201-212	pleckstrin homology like domain family A member 1	Homo sapiens	48-54
27278006-1	2016	We have recently shown that mRNA and protein of PHLDA1 (pleckstrin-homology-like domain family A, member  1) were by far the most upregulated molecules upon treatment of IMR-32 cells with the anti-GD2 ganglioside monoclonal antibody 14G2a.	Gangliosides	201-212	pleckstrin homology like domain family A member 1	Homo sapiens	56-107
27410738-8	2016	MHC I and IL-2Ralpha/IL-15Ralpha colocalized with GM1 ganglioside-rich lipid rafts, but MHC I clusters retracted to smaller subsets of GM1- and IL-2Ralpha/IL-15Ralpha-rich areas upon knockdown.	Gangliosides	54-65	interleukin 15 receptor subunit alpha	Homo sapiens	21-32
27123544-5	2016	In fact, the presence of lipid microdomains in MAMs has been detected and, in these structures, a molecular interaction of the ganglioside GD3, a paradigmatic "brick" of lipid rafts, with core-initiator proteins of autophagy, such as AMBRA1 and WIPI1, was revealed.	Gangliosides	127-138	GRDX	Homo sapiens	139-142
26860251-1	2016	Gangliosides are key lipid molecules required for the regulation of cellular processes such as proliferation, differentiation, and cell signaling, including signaling of epidermal growth factor receptor (EGFR).	Gangliosides	0-12	epidermal growth factor receptor	Sus scrofa	170-202
26860251-1	2016	Gangliosides are key lipid molecules required for the regulation of cellular processes such as proliferation, differentiation, and cell signaling, including signaling of epidermal growth factor receptor (EGFR).	Gangliosides	0-12	epidermal growth factor receptor	Sus scrofa	204-208
27292265-3	2016	At the onset of mitotic cell rounding, caveolin-1 is targeted to the retracting cortical region at the proximal end of retraction fibres, where ganglioside GM1-enriched membrane domains with clusters of caveola-like structures are formed in an integrin and RhoA-dependent manner.	Gangliosides	144-155	caveolin 1	Homo sapiens	39-49
27276264-5	2016	Furthermore, in the plasma membrane, CD81-ganglioside bridges arising from preformed glycolipid patches cross-link the complexes.	Gangliosides	42-53	CD81 molecule	Homo sapiens	37-41
27352802-6	2016	Moreover, alpha-synuclein (Parkinson) and Abeta peptide (Alzheimer) did no longer form Ca(2+)-permeable pores in presence of drugs that target either cholesterol or ganglioside or both membrane lipids.	Gangliosides	165-176	synuclein alpha	Homo sapiens	10-25
27352802-6	2016	Moreover, alpha-synuclein (Parkinson) and Abeta peptide (Alzheimer) did no longer form Ca(2+)-permeable pores in presence of drugs that target either cholesterol or ganglioside or both membrane lipids.	Gangliosides	165-176	amyloid beta precursor protein	Homo sapiens	42-47
26830059-7	2016	Epitopes recognized by cytotoxic antibodies were represented by gangliosides such as GD2 and GD3, as evidenced by cellular sialidase pretreatment and enhanced expression of distinct gangliosides.	Gangliosides	64-76	GRDX	Homo sapiens	93-96
26830059-7	2016	Epitopes recognized by cytotoxic antibodies were represented by gangliosides such as GD2 and GD3, as evidenced by cellular sialidase pretreatment and enhanced expression of distinct gangliosides.	Gangliosides	182-194	GRDX	Homo sapiens	93-96
27123544-5	2016	In fact, the presence of lipid microdomains in MAMs has been detected and, in these structures, a molecular interaction of the ganglioside GD3, a paradigmatic "brick" of lipid rafts, with core-initiator proteins of autophagy, such as AMBRA1 and WIPI1, was revealed.	Gangliosides	127-138	autophagy and beclin 1 regulator 1	Homo sapiens	234-240
27123544-5	2016	In fact, the presence of lipid microdomains in MAMs has been detected and, in these structures, a molecular interaction of the ganglioside GD3, a paradigmatic "brick" of lipid rafts, with core-initiator proteins of autophagy, such as AMBRA1 and WIPI1, was revealed.	Gangliosides	127-138	WD repeat domain, phosphoinositide interacting 1	Homo sapiens	245-250
27123544-7	2016	The functional activity of GD3 was suggested by the experiments carried out by knocking down ST8SIA1 gene expression, i.e., the synthase that leads to the ganglioside formation.	Gangliosides	155-166	GRDX	Homo sapiens	27-30
27123544-7	2016	The functional activity of GD3 was suggested by the experiments carried out by knocking down ST8SIA1 gene expression, i.e., the synthase that leads to the ganglioside formation.	Gangliosides	155-166	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	93-100
27070150-4	2016	Taking cholera toxin B subunit (CTB) as a model cooperativity system, we studied both GM1 and GM1-like gangliosides binding to CTB.	Gangliosides	103-115	phosphate cytidylyltransferase 1B, choline	Homo sapiens	127-130
27043189-4	2016	Single-fluorescent-molecule imaging in the live-cell plasma membrane revealed the clear but transient colocalization and codiffusion of fluorescent ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI)-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59"s transient homodimer rafts in quiescent cells, and 48 ms for engaged-CD59-cluster rafts, in cholesterol- and GPI-anchoring-dependent manners.	Gangliosides	148-159	CD59 molecule (CD59 blood group)	Homo sapiens	256-260
27043189-4	2016	Single-fluorescent-molecule imaging in the live-cell plasma membrane revealed the clear but transient colocalization and codiffusion of fluorescent ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI)-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59"s transient homodimer rafts in quiescent cells, and 48 ms for engaged-CD59-cluster rafts, in cholesterol- and GPI-anchoring-dependent manners.	Gangliosides	148-159	CD59 molecule (CD59 blood group)	Homo sapiens	290-294
27043189-4	2016	Single-fluorescent-molecule imaging in the live-cell plasma membrane revealed the clear but transient colocalization and codiffusion of fluorescent ganglioside analogs with a fluorescently labeled glycosylphosphatidylinisotol (GPI)-anchored protein, human CD59, with lifetimes of 12 ms for CD59 monomers, 40 ms for CD59"s transient homodimer rafts in quiescent cells, and 48 ms for engaged-CD59-cluster rafts, in cholesterol- and GPI-anchoring-dependent manners.	Gangliosides	148-159	CD59 molecule (CD59 blood group)	Homo sapiens	290-294
26649472-1	2016	Ganglioside GM3 synthase is a key enzyme involved in the biosynthesis of gangliosides.	Gangliosides	73-85	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-24
26984608-1	2016	Niemann-Pick disease type C (NP-C) is a fatal progressive neurolipidosis involving neuronal storage of cholesterol and gangliosides.	Gangliosides	119-131	NPC intracellular cholesterol transporter 1	Homo sapiens	0-27
26984608-1	2016	Niemann-Pick disease type C (NP-C) is a fatal progressive neurolipidosis involving neuronal storage of cholesterol and gangliosides.	Gangliosides	119-131	NPC intracellular cholesterol transporter 1	Homo sapiens	29-33
26805383-0	2016	Positive regulation of myoblast differentiation by medaka Neu3b sialidase through gangliosides desialylation.	Gangliosides	82-94	sialidase-3-like	Oryzias latipes	58-63
26805383-7	2016	Neu3b altered ganglioside composition in C2C12 cells results showing a decrease in GM2, and the increase of Lac-Cer, while desialylation of glycoproteins were not detected.	Gangliosides	14-25	sialidase-3-like	Oryzias latipes	0-5
26805383-2	2016	Previous study revealed that medaka Neu3b is localized at cytosol and is a ganglioside-specific sialidase.	Gangliosides	75-86	sialidase-3-like	Oryzias latipes	36-41
26804001-4	2016	Further studies using primary dorsal root ganglion neuron (DRGn) cultures demonstrated that anti-Gg Abs can inhibit neurite outgrowth by targeting gangliosides via activation of the small GTPase RhoA and its associated kinase (ROCK), a signaling pathway common to other established inhibitors of axon regeneration.	Gangliosides	147-159	ras homolog family member A	Homo sapiens	195-199
26626972-9	2016	Sulphamidase infusion mediated a statistically significant reduction in primary (heparan sulphate) and secondary (gangliosides GM2, GM3) substrate accumulation in the brain, with small reductions in micro- but not astro-gliosis.	Gangliosides	114-126	N-sulfoglucosamine sulfohydrolase (sulfamidase)	Mus musculus	0-12
26934353-6	2016	We used these human antibody fragments for generating GD3 ganglioside specific CAR gene constructs for potential usage in solid tumors.	Gangliosides	58-69	GRDX	Homo sapiens	54-57
27023584-8	2016	Gangliosides further attenuated Pb-induced the abnormal autophagic process by regulation of mTOR pathways.	Gangliosides	0-12	mechanistic target of rapamycin kinase	Homo sapiens	92-96
26704905-0	2016	Ganglioside GQ1b induces dopamine release through the activation of Pyk2.	Gangliosides	0-11	protein tyrosine kinase 2 beta	Rattus norvegicus	68-72
26808587-3	2016	The impact of diets containing complex lipids rich in milk-derived ganglioside GD3 on the biosynthesis of gangliosides (assessed from the incorporation of deuterium) in the frontal lobe of a piglet model is reported.	Gangliosides	67-78	GRDX	Homo sapiens	79-82
26808587-3	2016	The impact of diets containing complex lipids rich in milk-derived ganglioside GD3 on the biosynthesis of gangliosides (assessed from the incorporation of deuterium) in the frontal lobe of a piglet model is reported.	Gangliosides	106-118	GRDX	Homo sapiens	79-82
26792897-0	2016	Progenitor/Stem Cell Markers in Brain Adjacent to   Glioblastoma: GD3 Ganglioside and NG2 Proteoglycan   Expression.	Gangliosides	70-81	GRDX	Homo sapiens	66-69
26526326-2	2016	We describe here that galectin-1 (Gal-1), a homobivalent endogenous lectin, is an effector by cross-linking the ganglioside and its associated glycoprotein alpha5 beta1 -integrin.	Gangliosides	112-123	lectin, galactose binding, soluble 1	Mus musculus	22-32
26526326-2	2016	We describe here that galectin-1 (Gal-1), a homobivalent endogenous lectin, is an effector by cross-linking the ganglioside and its associated glycoprotein alpha5 beta1 -integrin.	Gangliosides	112-123	lectin, galactose binding, soluble 1	Mus musculus	34-39
26526326-7	2016	Gal-1, as cross-linking lectin, can thus translate metabolic conversion of ganglioside GD1a to GM1 by neuraminidase action into axon growth.	Gangliosides	75-86	lectin, galactose binding, soluble 1	Mus musculus	0-5
26655601-2	2016	Recently we deciphered the ganglioside-recognition code controlling specific ganglioside binding to Alzheimer"s beta-amyloid (Abeta1-42) peptide and Parkinson"s disease-associated protein alpha-synuclein.	Gangliosides	27-38	synuclein alpha	Rattus norvegicus	188-203
26655601-2	2016	Recently we deciphered the ganglioside-recognition code controlling specific ganglioside binding to Alzheimer"s beta-amyloid (Abeta1-42) peptide and Parkinson"s disease-associated protein alpha-synuclein.	Gangliosides	77-88	synuclein alpha	Rattus norvegicus	188-203
26655601-3	2016	Cracking this code allowed us to engineer a short chimeric Abeta/alpha-synuclein peptide that recognizes all brain gangliosides.	Gangliosides	115-127	amyloid beta precursor protein	Rattus norvegicus	59-64
26655601-3	2016	Cracking this code allowed us to engineer a short chimeric Abeta/alpha-synuclein peptide that recognizes all brain gangliosides.	Gangliosides	115-127	synuclein alpha	Rattus norvegicus	65-80
26498762-4	2016	In addition, we reported that epigenetic activation of the GalNAcT gene was also detected as accompanied by an apparent induction of neuronal differentiation in neural stem cells responding to an exogenous supplement of ganglioside GM1.	Gangliosides	220-231	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	59-66
26553874-6	2016	The membrane rafts surrounding desialylated PrP(C) contained greater amounts of sialylated gangliosides and cholesterol than membrane rafts surrounding PrP(C).	Gangliosides	91-103	prion protein	Mus musculus	44-50
26720275-1	2016	Membrane-wrapped nanoparticles represent a versatile platform for utilizing specific lipid-receptor interactions, such as siallyllactose-mediated binding of the ganglioside GM3 to Siglec1 (CD169), for targeting purposes.	Gangliosides	161-172	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	180-187
26720275-1	2016	Membrane-wrapped nanoparticles represent a versatile platform for utilizing specific lipid-receptor interactions, such as siallyllactose-mediated binding of the ganglioside GM3 to Siglec1 (CD169), for targeting purposes.	Gangliosides	161-172	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	189-194
26711146-4	2016	The clustering of lipid rafts in plasma membranes of MOLT-4 cells was examined with a marker Cholera toxin subunit B conjugates Alexa Fluor (CTB), which binds to the pentasaccharide chains of ganglioside GM1 on the cellular surfaces.	Gangliosides	192-203	phosphate cytidylyltransferase 1B, choline	Homo sapiens	141-144
26629687-0	2015	Intraventricular Sialidase Administration Enhances GM1 Ganglioside Expression and Is Partially Neuroprotective in a Mouse Model of Parkinson"s Disease.	Gangliosides	55-66	coenzyme Q10A	Mus musculus	51-54
27035458-6	2016	RESULTS: GM3 appeared to be by far the major ganglioside of human plasma, associated with GD3.	Gangliosides	45-56	GRDX	Homo sapiens	90-93
27035458-8	2016	Fourteen molecular species of GM3 and 9 species of GD3, accounting for the variability of the ceramide moiety of the ganglioside molecule, were identified and characterized.	Gangliosides	117-128	GRDX	Homo sapiens	51-54
26699276-9	2015	Further, we revealed that epidermal growth factor signaling and gangliosides are necessary components on Abeta-stimulated NSC proliferation.	Gangliosides	64-76	amyloid beta (A4) precursor protein	Mus musculus	105-110
27578923-6	2016	Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2.	Gangliosides	0-11	phospholipase A2 group IVA	Homo sapiens	57-83
27578923-6	2016	Ganglioside cross-linking resulted in phosphorylation of cytosolic phospholipase A2 and increased expression of cyclooxygenase-2.	Gangliosides	0-11	prostaglandin-endoperoxide synthase 2	Homo sapiens	112-128
27578923-8	2016	Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-alpha.	Gangliosides	30-42	interleukin 4	Homo sapiens	108-121
27578923-8	2016	Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-alpha.	Gangliosides	30-42	interleukin 6	Homo sapiens	123-136
27578923-8	2016	Cross-linking of GD1b derived gangliosides also resulted in the release of the newly synthesized mediators, interleukin-4, interleukin-6, and TNF-alpha.	Gangliosides	30-42	tumor necrosis factor	Homo sapiens	142-151
27578923-10	2016	Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFkappaB and NFAT in a Syk-dependent manner.	Gangliosides	18-30	mitogen-activated protein kinase 3	Homo sapiens	62-68
27578923-10	2016	Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFkappaB and NFAT in a Syk-dependent manner.	Gangliosides	18-30	mitogen-activated protein kinase 8	Homo sapiens	70-76
27578923-10	2016	Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFkappaB and NFAT in a Syk-dependent manner.	Gangliosides	18-30	mitogen-activated protein kinase 1	Homo sapiens	82-85
27578923-10	2016	Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFkappaB and NFAT in a Syk-dependent manner.	Gangliosides	18-30	nuclear factor kappa B subunit 1	Homo sapiens	113-121
27578923-10	2016	Cross-linking the gangliosides induced the phosphorylation of ERK1/2, JNK1/2, and p38 as well as activating both NFkappaB and NFAT in a Syk-dependent manner.	Gangliosides	18-30	spleen associated tyrosine kinase	Homo sapiens	136-139
26729095-3	2015	In parallel, gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 biosynthesis was upregulated by SD in MG-63 cells.	Gangliosides	74-85	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	38-50
26729095-3	2015	In parallel, gene expression of human GM3 synthase (hST3Gal V) catalyzing ganglioside GM3 biosynthesis was upregulated by SD in MG-63 cells.	Gangliosides	74-85	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	52-61
26629687-4	2015	METHODS: We used sialidase from Vibrio cholerae (VCS) to convert GD1a, GD1b and GT1b gangliosides to GM1.	Gangliosides	85-97	coenzyme Q10A	Mus musculus	101-104
26263924-4	2015	To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naive Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).	Gangliosides	43-54	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	259-274
26263924-4	2015	To understand this increase as a result of ganglioside up-regulation, we observed that very early after activation, human naive Th cells show an increased expression in surface GD3 and neoexpression of surface GD2 gangliosides, the latter clustering with the T cell receptor (TCR).	Gangliosides	43-54	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	276-279
26370074-1	2015	Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides.	Gangliosides	181-193	sialic acid binding Ig like lectin 1	Homo sapiens	0-8
26362868-4	2015	We investigated two glycosyltransferases, ST3Gal5 (ST3G5) and B4GalNAcT1 (B4GN1), involved in ganglioside synthesis and examined their signal sequences for ER export and Golgi retention.	Gangliosides	94-105	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	42-49
26362868-4	2015	We investigated two glycosyltransferases, ST3Gal5 (ST3G5) and B4GalNAcT1 (B4GN1), involved in ganglioside synthesis and examined their signal sequences for ER export and Golgi retention.	Gangliosides	94-105	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	51-56
26370074-1	2015	Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides.	Gangliosides	181-193	sialic acid binding Ig like lectin 1	Homo sapiens	10-22
26370074-1	2015	Siglec-1 (sialoadhesin, CD169) is a surface receptor on human cells that mediates trans-enhancement of HIV-1 infection through recognition of sialic acid moieties in virus membrane gangliosides.	Gangliosides	181-193	sialic acid binding Ig like lectin 1	Homo sapiens	24-29
26370074-5	2015	To explore the role of sialic acid for MLV trans-infection at a submolecular level, we analyzed the potential of six sialic acid precursor analogs to modulate the sialylated ganglioside-dependent interaction of MLV particles with Siglec-1.	Gangliosides	174-185	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	230-238
26431038-7	2015	Supplementing the growth media with GM1, the major ganglioside present at the cell surface, restored phagocytic activity of Sptlc2-/- DC2.4 cells.	Gangliosides	51-62	coenzyme Q10A	Mus musculus	36-39
26338710-0	2015	Ganglioside GM1 Contributes to the State of Insulin Resistance in Senescent Human Arterial Endothelial Cells.	Gangliosides	0-11	insulin	Homo sapiens	44-51
26401073-7	2015	Ganglioside catabolism enzymes beta-hexosaminidase A (HEXA) and sialidase-3 (NEU3) were measured in intestinal mucosa using western blot and compared among subject groups.	Gangliosides	0-11	hexosaminidase subunit alpha	Homo sapiens	31-52
26038579-3	2015	Lipid microdomains contain large quantities of cholesterol and glycosphingolipids, including glucosylceramide synthase (GCS) (gene Ugcg)-derived gangliosides.	Gangliosides	145-157	UDP-glucose ceramide glucosyltransferase	Mus musculus	93-118
26038579-3	2015	Lipid microdomains contain large quantities of cholesterol and glycosphingolipids, including glucosylceramide synthase (GCS) (gene Ugcg)-derived gangliosides.	Gangliosides	145-157	UDP-glucose ceramide glucosyltransferase	Mus musculus	120-123
26038579-8	2015	In addition to studies suggesting that simple gangliosides like GM3 regulate peripheral IR signaling, this work suggests that complex neuronal gangliosides also modulate hypothalamic IR signaling and protein levels.	Gangliosides	143-155	insulin receptor	Mus musculus	183-185
25810027-0	2015	Sialidase NEU3 contributes neoplastic potential on colon cancer cells as a key modulator of gangliosides by regulating Wnt signaling.	Gangliosides	92-104	neuraminidase 3	Homo sapiens	10-14
25810027-1	2015	The plasma membrane-associated sialidase NEU3 is a key enzyme for ganglioside degradation.	Gangliosides	66-77	neuraminidase 3	Homo sapiens	41-45
26492617-7	2015	The selected scFv clones were analyzed for inhibition of tetanus toxin binding to ganglioside GT1b.	Gangliosides	82-93	immunglobulin heavy chain variable region	Homo sapiens	13-17
26401073-7	2015	Ganglioside catabolism enzymes beta-hexosaminidase A (HEXA) and sialidase-3 (NEU3) were measured in intestinal mucosa using western blot and compared among subject groups.	Gangliosides	0-11	hexosaminidase subunit alpha	Homo sapiens	54-58
26401073-7	2015	Ganglioside catabolism enzymes beta-hexosaminidase A (HEXA) and sialidase-3 (NEU3) were measured in intestinal mucosa using western blot and compared among subject groups.	Gangliosides	0-11	neuraminidase 3	Homo sapiens	77-81
26401073-11	2015	GD3 and GD1a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine.	Gangliosides	24-35	GRDX	Homo sapiens	0-3
26115843-4	2015	We found that both ceramide analogs D- and L-PDMP (1-phenyl 2-decanoylamino-3-morpholino-1-propanol), which have opposite effects on ganglioside synthesis, selectively inhibited GSK3beta via Ser9 phosphorylation independently of the upstream insulin/Akt pathway.	Gangliosides	133-144	glycogen synthase kinase 3 beta	Homo sapiens	178-186
26022181-1	2015	The plasma membrane-associated enzyme NEU3 sialidase functions to cleave sialic acid residues from the ganglioside GM3 thereby promoting its degradation, and has been implicated in the modulation of insulin action.	Gangliosides	103-114	neuraminidase 3	Rattus norvegicus	38-42
26115843-4	2015	We found that both ceramide analogs D- and L-PDMP (1-phenyl 2-decanoylamino-3-morpholino-1-propanol), which have opposite effects on ganglioside synthesis, selectively inhibited GSK3beta via Ser9 phosphorylation independently of the upstream insulin/Akt pathway.	Gangliosides	133-144	insulin	Homo sapiens	242-249
26115843-4	2015	We found that both ceramide analogs D- and L-PDMP (1-phenyl 2-decanoylamino-3-morpholino-1-propanol), which have opposite effects on ganglioside synthesis, selectively inhibited GSK3beta via Ser9 phosphorylation independently of the upstream insulin/Akt pathway.	Gangliosides	133-144	AKT serine/threonine kinase 1	Homo sapiens	250-253
26054879-0	2015	Ganglioside GD1a suppresses LPS-induced pro-inflammatory cytokines in RAW264.7 macrophages by reducing MAPKs and NF-kappaB signaling pathways through TLR4.	Gangliosides	0-11	toll like receptor 4	Homo sapiens	150-154
25981177-0	2015	Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.	Gangliosides	0-11	brain abundant, membrane attached signal protein 1	Rattus norvegicus	29-78
26459480-0	2015	Role of Protein Kinase Akt Activation in Protective Effect of Ganglioside GM1 on PC12 Cells Exposed to H2O2.	Gangliosides	62-73	Akt1	Drosophila melanogaster	23-26
26459480-5	2015	These findings suggest that activation of protein kinase Akt by GM1 contributes to improvement of PC12 cell viability by this ganglioside.	Gangliosides	126-137	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
25981177-0	2015	Ganglioside contained in the neuronal tissue-enriched acidic protein of 22 kDa (NAP-22) fraction prepared from the detergent-resistant membrane microdomain of rat brain inhibits the phosphatase activity of calcineurin.	Gangliosides	0-11	brain abundant, membrane attached signal protein 1	Rattus norvegicus	80-86
25981177-11	2015	These results show that DRM-derived NAP-22 binds several lipids, including ganglioside, and that ganglioside inhibits the phosphatase activity of CaN.	Gangliosides	75-86	brain abundant, membrane attached signal protein 1	Rattus norvegicus	36-42
26937414-0	2015	Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay-Sachs mouse models.	Gangliosides	82-94	neuraminidase 1	Mus musculus	0-15
26250646-2	2015	In this work, we conducted coarse-grained simulation to investigate the interactions of binding units of chorela toxin (CTB) with mixed ganglioside GM1 and dipalmitoylphosphatidylcholine (DPPC) lipid bilayer membrane.	Gangliosides	136-147	chitobiase	Homo sapiens	120-123
26251452-2	2015	Sialidase NEU3 is a key enzyme in the catabolism of gangliosides with its up-regulation having been observed in human cancer cells.	Gangliosides	52-64	neuraminidase 3	Homo sapiens	10-14
26251452-4	2015	In the present study, we found an increased internalization of Tf (transferrin), the archetypical cargo for CME, in cells expressing complex gangliosides with high levels of sialylation.	Gangliosides	141-153	transferrin	Homo sapiens	63-65
26251452-4	2015	In the present study, we found an increased internalization of Tf (transferrin), the archetypical cargo for CME, in cells expressing complex gangliosides with high levels of sialylation.	Gangliosides	141-153	transferrin	Homo sapiens	67-78
26251452-5	2015	The ectopic expression of NEU3 led to a drastic decrease in Tf endocytosis, suggesting the participation of gangliosides in this process.	Gangliosides	108-120	neuraminidase 3	Homo sapiens	26-30
26251452-5	2015	The ectopic expression of NEU3 led to a drastic decrease in Tf endocytosis, suggesting the participation of gangliosides in this process.	Gangliosides	108-120	transferrin	Homo sapiens	60-62
26252487-0	2015	Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology.	Gangliosides	32-43	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	54-57
26275242-10	2015	Inhibiting GBA2 in Npc1-/- mice with a brain-permeable low nanomolar inhibitor significantly improved motor coordination and extended lifespan in the absence of correction in cholesterol and ganglioside abnormalities.	Gangliosides	191-202	glucosidase beta 2	Mus musculus	11-15
26108617-6	2015	Inhibition of glucosylceramide and ganglioside synthesis results in improved insulin sensitivity and increased activatory tyrosine phosphorylation of IRS1 in the muscle.	Gangliosides	35-46	insulin	Homo sapiens	77-84
26108617-6	2015	Inhibition of glucosylceramide and ganglioside synthesis results in improved insulin sensitivity and increased activatory tyrosine phosphorylation of IRS1 in the muscle.	Gangliosides	35-46	insulin receptor substrate 1	Homo sapiens	150-154
26063460-0	2015	Ganglioside accumulation in activated glia in the developing brain: comparison between WT and GalNAcT KO mice.	Gangliosides	0-11	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	94-101
26542007-1	2015	The specific interaction of ganglioside GM1 with the homodimeric (prototype) endogenous lectin galectin-1 triggers growth regulation in tumor and activated effector T cells.	Gangliosides	28-39	galectin 1	Homo sapiens	95-105
26101831-8	2015	Delipidated NAP-22 bound phosphatidylserine (PS), phosphatidylinosotol, and ganglioside.	Gangliosides	76-87	brain abundant membrane attached signal protein 1	Homo sapiens	12-18
26226135-3	2015	Culturing T lymphocytes with GBM cell line derived gangliosides (10-20 mug/ml) demonstrated increased ROS production as early as 18 hrs as indicated by increased uptake of the dye H2DCFDA while western blotting demonstrated mitochondrial damage as evident by cleavage of Bid to t-Bid and by the release of cytochrome-c into the cytosol.	Gangliosides	51-63	BH3 interacting domain death agonist	Homo sapiens	271-274
26226135-3	2015	Culturing T lymphocytes with GBM cell line derived gangliosides (10-20 mug/ml) demonstrated increased ROS production as early as 18 hrs as indicated by increased uptake of the dye H2DCFDA while western blotting demonstrated mitochondrial damage as evident by cleavage of Bid to t-Bid and by the release of cytochrome-c into the cytosol.	Gangliosides	51-63	BH3 interacting domain death agonist	Homo sapiens	280-283
25937317-3	2015	Proteins enriched in lysine and other positively charged residues (histidine and arginine) as well as glycosaminoglycans and gangliosides bind Plg.	Gangliosides	125-137	plasminogen	Homo sapiens	143-146
25916169-1	2015	ST3Gal-II, a type II transmembrane protein, is the main mammalian sialyltransferase responsible for GD1a and GT1b ganglioside biosynthesis in brain.	Gangliosides	114-125	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	0-9
25503644-0	2015	Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
26056266-3	2015	Levels of ceramide, glucosylceramide, galactocerebroside, lactosylceramide, globotriaosylceramide, and the gangliosides GM3 and GM1 were significantly elevated in spinal cords of ALS patients.	Gangliosides	107-119	granulocyte macrophage antigen 3	Mus musculus	120-123
26086081-0	2015	Increased Expression of Simple Ganglioside Species GM2 and GM3 Detected by MALDI Imaging Mass Spectrometry in a Combined Rat Model of Abeta Toxicity and Stroke.	Gangliosides	31-42	amyloid beta precursor protein	Rattus norvegicus	134-139
26086081-8	2015	By 3 d, a significant increase in the simple ganglioside species GM2 was observed in the ischemic brain region of rats who received a stroke (ET-1), with or without Abeta.	Gangliosides	45-56	endothelin 1	Rattus norvegicus	142-146
25992726-7	2015	In systems mimicking biological membranes, the CD3epsilon chain localization is modulated by different facilitator lipids (e.g., gangliosides or phosphoinositols), revealing a plausible regulatory effect on activation through the regulation of lipid composition in cell membranes.	Gangliosides	129-141	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	47-57
25947229-4	2015	RESULTS: Here we show that IFNalpha-activated dendritic cells, monocytes and macrophages have an enhanced ability to capture and trans-infect HIV-1 via Siglec-1 recognition of viral membrane gangliosides.	Gangliosides	191-203	sialic acid binding Ig like lectin 1	Homo sapiens	152-160
25673107-6	2015	In the review, we gather and discuss data of various research groups on direct cytotoxic effects elicited by several ganglioside-specific antibodies, which bind to GM2, N-acetyl-GM2, N-glycolyl-GM2, GM3, GD3, GD2, O-acetyl-GD2, without involvement of immunological mechanisms.	Gangliosides	117-128	GRDX	Homo sapiens	204-207
25677621-0	2015	b-Series gangliosides crucially regulate leptin secretion in adipose tissues.	Gangliosides	9-21	leptin	Mus musculus	41-47
25677621-3	2015	Genetic deletion of b-series gangliosides resulted in the marked reduction of serum leptin.	Gangliosides	29-41	leptin	Mus musculus	84-90
25677621-7	2015	Results of methyl-beta-cyclodextrin treatment of differentiated 3T3-L1 cells as well as immunocytostaining of leptin and caveolin-1 suggested that b-series gangliosides regulate the leptin secretion from adipose tissues in lipid rafts.	Gangliosides	156-168	leptin	Mus musculus	110-116
25677621-7	2015	Results of methyl-beta-cyclodextrin treatment of differentiated 3T3-L1 cells as well as immunocytostaining of leptin and caveolin-1 suggested that b-series gangliosides regulate the leptin secretion from adipose tissues in lipid rafts.	Gangliosides	156-168	caveolin 1, caveolae protein	Mus musculus	121-131
25677621-7	2015	Results of methyl-beta-cyclodextrin treatment of differentiated 3T3-L1 cells as well as immunocytostaining of leptin and caveolin-1 suggested that b-series gangliosides regulate the leptin secretion from adipose tissues in lipid rafts.	Gangliosides	156-168	leptin	Mus musculus	182-188
25940087-0	2015	Ganglioside GD3 Enhances Invasiveness of Gliomas by Forming a Complex with Platelet-derived Growth Factor Receptor alpha and Yes Kinase.	Gangliosides	0-11	platelet derived growth factor receptor, alpha polypeptide	Mus musculus	75-120
27858733-6	2015	In other chronic neuropathies, antibodies against disialylated gangliosides including GD1b and GD3 are detected in ataxic neuropathies, usually associated with an IgM paraprotein, and antibodies against GM1 and the complex GM1:GalC are frequently found in multifocal motor neuropathy.	Gangliosides	63-75	galactosylceramidase	Homo sapiens	227-231
25652401-1	2015	GM3 synthase (ST3GAL5) is the first biosynthetic enzyme of a- and b-series gangliosides.	Gangliosides	75-87	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
25652401-1	2015	GM3 synthase (ST3GAL5) is the first biosynthetic enzyme of a- and b-series gangliosides.	Gangliosides	75-87	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	14-21
25795792-8	2015	The storage of BMP and ganglioside GM2 in brain were reduced similarly following adeno-associated viral-mediated gene therapy in Sandhoff disease mice.	Gangliosides	23-34	cytochrome b5 domain containing 2	Mus musculus	35-38
25503644-0	2015	Ganglioside GM3 exerts opposite effects on motility via epidermal growth factor receptor and hepatocyte growth factor receptor-mediated migration signaling.	Gangliosides	0-11	met proto-oncogene	Mus musculus	93-126
25503644-1	2015	The ganglioside GM3 exerts its different effects via various growth factor receptors.	Gangliosides	4-15	granulocyte macrophage antigen 3	Mus musculus	16-19
25193136-0	2015	Distinct selectivity of gangliosides required for CD4+ T and CD8+ T cell activation.	Gangliosides	24-36	CD4 molecule	Homo sapiens	50-53
25803810-1	2015	We previously demonstrated that sialidase NEU3, a key glycosidase for ganglioside degradation, is up-regulated in various human cancers, leading to increased cell invasion, motility and survival of cancer cells possibly through activation of EGF signaling.	Gangliosides	70-81	neuraminidase 3	Homo sapiens	42-46
25803810-8	2015	The activity-null mutants failed to activate Src and EGFR, indicating that ganglioside modulation by NEU3 may be necessary for the activation.	Gangliosides	75-86	neuraminidase 3	Homo sapiens	101-105
25760631-1	2015	Myeloid dendritic cells (DCs) can capture HIV-1 via the receptor CD169/Siglec-1 that binds to the ganglioside, GM3, in the virus particle membrane.	Gangliosides	98-109	sialic acid binding Ig like lectin 1	Homo sapiens	65-70
25303960-1	2015	Ganglioside GM3 (Siaalpha2-3Galbeta1-4Glcbeta1-1Cer) has been known to participate in insulin signaling by regulating the association of the insulin receptor in caveolae microdomains (lipid rafts), which is essential for the execution of the complete insulin metabolic signaling in adipocytes.	Gangliosides	0-11	insulin receptor	Mus musculus	141-157
25349165-0	2015	Evidence that small molecule enhancement of beta-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Abeta.	Gangliosides	153-164	O-GlcNAcase	Mus musculus	44-63
25349165-0	2015	Evidence that small molecule enhancement of beta-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Abeta.	Gangliosides	153-164	amyloid beta (A4) precursor protein	Mus musculus	171-176
25349165-1	2015	Certain mutant Alzheimer"s amyloid-beta (Abeta) peptides (that is, Dutch mutant APP(E693Q)) form complexes with gangliosides (GAbeta).	Gangliosides	112-124	amyloid beta (A4) precursor protein	Mus musculus	41-46
25349165-1	2015	Certain mutant Alzheimer"s amyloid-beta (Abeta) peptides (that is, Dutch mutant APP(E693Q)) form complexes with gangliosides (GAbeta).	Gangliosides	112-124	glucosidase, alpha, acid	Mus musculus	126-132
25406316-2	2015	Abeta peptides were previously considered to interact specifically with ganglioside-containing membranes.	Gangliosides	72-83	amyloid beta precursor protein	Homo sapiens	0-5
25515709-7	2015	Neonatal SD-HexB-treated mice had a significant increase in brain beta-hexosaminidase activity, and a reduction in G(M2) ganglioside storage and neuroinflammation compared to adult SD-HexB- and SD-LacZ-treated groups.	Gangliosides	121-132	hexosaminidase B	Mus musculus	12-16
25613425-5	2015	The important role of the sialosyl group of GM3 was demonstrated using NEU3, a plasma membrane-associated sialidase that selectively remove sialic acids from gangliosides GM3 and GD1a and is up-regulated in many human cancer cells.	Gangliosides	158-170	neuraminidase 3	Homo sapiens	71-75
25699169-2	2015	Here, we describe a role for complex gangliosides synthesized by the Galgt1 gene in muscle regeneration.	Gangliosides	37-49	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	69-75
25699169-14	2015	CONCLUSIONS: These experiments demonstrate a role for Galgt1 in skeletal muscle regeneration and suggest that complex gangliosides made by Galgt1 modulate the survival and differentiation of satellite cells.	Gangliosides	118-130	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	54-60
25699169-14	2015	CONCLUSIONS: These experiments demonstrate a role for Galgt1 in skeletal muscle regeneration and suggest that complex gangliosides made by Galgt1 modulate the survival and differentiation of satellite cells.	Gangliosides	118-130	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	139-145
26149926-8	2015	Upon interaction with the lipid raft components, such as cholesterol, gangliosides and phospholipids, Abeta can aggregate on the cell membrane and thereby disrupt it, perhaps by forming channel-like pores.	Gangliosides	70-82	amyloid beta precursor protein	Homo sapiens	102-107
24958345-6	2015	Cholera toxin subunit B (CTB)-specific antibodies immobilized onto superparamagnetic beads and ganglioside GM1-containing liposomes were used for CTB recognition in the detection system.	Gangliosides	95-106	phosphate cytidylyltransferase 1B, choline	Homo sapiens	146-149
25193136-0	2015	Distinct selectivity of gangliosides required for CD4+ T and CD8+ T cell activation.	Gangliosides	24-36	CD8a molecule	Homo sapiens	61-64
25045067-6	2015	Our findings show that the ganglioside 9OacGD3 is expressed heterogeneously and transiently in ES cells, and this expression corresponds to higher levels of Sox2 and Nestin transcripts.	Gangliosides	27-38	SRY (sex determining region Y)-box 2	Mus musculus	157-161
25395676-2	2015	We previously demonstrated that SVS2 regulates fertilization in mice; SVS2 is attached to a ganglioside GM1 on the plasma membrane of the sperm head and inhibits sperm capacitation in in vitro fertilization as a decapacitation factor.	Gangliosides	92-103	semenogelin 1	Mus musculus	32-36
25395676-2	2015	We previously demonstrated that SVS2 regulates fertilization in mice; SVS2 is attached to a ganglioside GM1 on the plasma membrane of the sperm head and inhibits sperm capacitation in in vitro fertilization as a decapacitation factor.	Gangliosides	92-103	semenogelin 1	Mus musculus	70-74
25045067-6	2015	Our findings show that the ganglioside 9OacGD3 is expressed heterogeneously and transiently in ES cells, and this expression corresponds to higher levels of Sox2 and Nestin transcripts.	Gangliosides	27-38	nestin	Mus musculus	166-172
24276958-3	2015	Although the involvement and relevance of its sialic acid binding activity is still controversial, it could be demonstrated that interactions of MAG with sialylated gangliosides play an important role in axon stability and regeneration.	Gangliosides	165-177	myelin associated glycoprotein	Homo sapiens	145-148
25448159-2	2015	This study demonstrates attenuated GDNF signaling in neurons deficient in ganglio-series gangliosides, and restoration of such signaling with LIGA20, a membrane permeable analog of GM1.	Gangliosides	89-101	glial cell line derived neurotrophic factor	Mus musculus	35-39
25483668-2	2015	Our results demonstrated that the 293E expression system could produce high level of recombinant secreted BHc protein, which was immunorecognized specifically by anti-botulinum neurotoxin serotype B (BoNT/B) sera and showed ganglioside binding activities.	Gangliosides	224-235	PHD finger protein 21A	Mus musculus	106-109
25483668-6	2015	And a solid-phase assay showed that the neutralizing antibodies from the BHc-immunized mice inhibited the binding of BHc to the ganglioside GT1b.	Gangliosides	128-139	PHD finger protein 21A	Mus musculus	73-76
25483668-6	2015	And a solid-phase assay showed that the neutralizing antibodies from the BHc-immunized mice inhibited the binding of BHc to the ganglioside GT1b.	Gangliosides	128-139	PHD finger protein 21A	Mus musculus	117-120
25520869-0	2014	Caveolin-1-dependent and -independent uPAR signaling pathways contribute to ganglioside GT1b induced early apoptosis in A549 lung cancer cells.	Gangliosides	76-87	caveolin 1	Homo sapiens	0-10
25425333-2	2014	Ganglioside GM1 has been shown to be responsible for the binding of the B subunit of cholera toxin (CT-B), which then helps CT to pass through the membrane, but the exact mechanism remains to be explored.	Gangliosides	0-11	phosphate cytidylyltransferase 1B, choline	Homo sapiens	100-104
25399921-5	2014	We have proposed that the binding of Abeta to membranes with ganglioside clusters plays an important role in the abnormal aggregation of Abeta.	Gangliosides	61-72	amyloid beta precursor protein	Homo sapiens	37-42
25399921-5	2014	We have proposed that the binding of Abeta to membranes with ganglioside clusters plays an important role in the abnormal aggregation of Abeta.	Gangliosides	61-72	amyloid beta precursor protein	Homo sapiens	137-142
25399921-9	2014	Thus, our ganglioside cluster-mediated amyloidogenesis hypothesis explains the immunity of rodents from cerebral Abeta amyloid deposition, strengthening the importance of ganglioside clusters as a platform of abnormal Abeta deposition in the pathology of AD.	Gangliosides	10-21	amyloid beta precursor protein	Homo sapiens	113-118
25399921-9	2014	Thus, our ganglioside cluster-mediated amyloidogenesis hypothesis explains the immunity of rodents from cerebral Abeta amyloid deposition, strengthening the importance of ganglioside clusters as a platform of abnormal Abeta deposition in the pathology of AD.	Gangliosides	10-21	amyloid beta precursor protein	Homo sapiens	218-223
25399921-9	2014	Thus, our ganglioside cluster-mediated amyloidogenesis hypothesis explains the immunity of rodents from cerebral Abeta amyloid deposition, strengthening the importance of ganglioside clusters as a platform of abnormal Abeta deposition in the pathology of AD.	Gangliosides	171-182	amyloid beta precursor protein	Homo sapiens	218-223
25520869-0	2014	Caveolin-1-dependent and -independent uPAR signaling pathways contribute to ganglioside GT1b induced early apoptosis in A549 lung cancer cells.	Gangliosides	76-87	plasminogen activator, urokinase receptor	Homo sapiens	38-42
25520869-3	2014	In this study, we show that the ganglioside GT1b induces proapoptotic signaling through two uPAR-ERK signaling pathways in A549 lung cancer cells.	Gangliosides	32-43	plasminogen activator, urokinase receptor	Homo sapiens	92-96
25520869-3	2014	In this study, we show that the ganglioside GT1b induces proapoptotic signaling through two uPAR-ERK signaling pathways in A549 lung cancer cells.	Gangliosides	32-43	EPH receptor B2	Homo sapiens	97-100
25234733-1	2014	Mammalian Neu3 is a ganglioside specific sialidase.	Gangliosides	20-31	neuraminidase 3	Homo sapiens	10-14
25234733-9	2014	Lysate from neu3 genes transfected HEK293 cells showed sialidase activity in Neu3a towards ganglioside mix optimally at pH4.6.	Gangliosides	91-102	neuraminidase 3	Homo sapiens	12-16
25234733-9	2014	Lysate from neu3 genes transfected HEK293 cells showed sialidase activity in Neu3a towards ganglioside mix optimally at pH4.6.	Gangliosides	91-102	sialidase-4-like	Oreochromis niloticus	77-82
25234733-10	2014	Using pure gangliosides as substrates, highest sialidase activity for Neu3a was observed towards GD3 followed by GD1a and GM3, but not GM1.	Gangliosides	11-23	sialidase-4-like	Oreochromis niloticus	70-75
24903509-4	2014	In lipid rafts, interactions of glycosphingolipids, including ganglioside, with proteins may be responsible for the misfolding events that cause the fibril and/or aggregate processing of disease-specific proteins, such as alpha-synuclein, in Parkinson"s disease, huntingtin protein in Huntington"s disease, and copper-zinc superoxide dismutase in amyotrophic lateral sclerosis.	Gangliosides	62-73	synuclein alpha	Homo sapiens	222-237
24995708-5	2014	The purified PIB-binding site comprises a distinct, highly insoluble subfraction of the Abeta in AD brain with low buoyant density because of the sodium dodecyl sulfate-resistant association with a limited subset of brain proteins and lipids with physical properties similar to lipid rafts and to a ganglioside:Abeta complex in AD and Down syndrome brain.	Gangliosides	299-310	amyloid beta precursor protein	Homo sapiens	88-93
25149363-8	2014	Gangliosides, lipid raft clustering, and CD44-membrane microdomain interactions were increased in the plasma membrane of Cd82-null ECs, leading to less clathrin-independent endocytosis and then more surface presence of CD44.	Gangliosides	0-12	CD82 antigen	Mus musculus	121-125
25149363-9	2014	CONCLUSIONS: Our study reveals that CD82 restrains pathological angiogenesis by inhibiting EC movement, that lipid raft clustering and cell adhesion molecule trafficking modulate angiogenic potential, that transmembrane protein modulates lipid rafts, and that the perturbation of CD82-ganglioside-CD44 signaling attenuates pathological angiogenesis.	Gangliosides	285-296	CD82 antigen	Mus musculus	36-40
24903509-4	2014	In lipid rafts, interactions of glycosphingolipids, including ganglioside, with proteins may be responsible for the misfolding events that cause the fibril and/or aggregate processing of disease-specific proteins, such as alpha-synuclein, in Parkinson"s disease, huntingtin protein in Huntington"s disease, and copper-zinc superoxide dismutase in amyotrophic lateral sclerosis.	Gangliosides	62-73	huntingtin	Homo sapiens	263-273
25230315-6	2014	Cross-linking Siglec-7 with its ligand, ganglioside, resulted in platelet apoptosis without any significant effects on activation, aggregation, cell morphology by electron microscopy analysis or secretion.	Gangliosides	40-51	sialic acid binding Ig like lectin 7	Homo sapiens	14-22
25253868-11	2014	Release of ganglioside binding may enhance GluR2-containing AMPAR association with its trafficking complexes, increasing endocytosis.	Gangliosides	11-22	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	43-48
25253868-12	2014	Disrupting ganglioside biosynthesis may result in reduced synaptic expression of GluR2-contianing AMPARs resulting in intellectual deficits and seizure susceptibility in mice and humans.	Gangliosides	11-22	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	81-86
25230315-7	2014	We show that ganglioside triggered four key pathways leading to apoptosis in human platelets: (i) mitochondrial inner transmembrane potential (DeltaPsim) depolarization; (ii) elevated expression of pro-apoptotic Bax and Bak proteins with reduced expression of anti-apoptotic Bcl-2 protein; (iii) phosphatidylserine exposure and (iv), microparticle formation.	Gangliosides	13-24	BCL2 associated X, apoptosis regulator	Homo sapiens	212-215
25230315-7	2014	We show that ganglioside triggered four key pathways leading to apoptosis in human platelets: (i) mitochondrial inner transmembrane potential (DeltaPsim) depolarization; (ii) elevated expression of pro-apoptotic Bax and Bak proteins with reduced expression of anti-apoptotic Bcl-2 protein; (iii) phosphatidylserine exposure and (iv), microparticle formation.	Gangliosides	13-24	BCL2 antagonist/killer 1	Homo sapiens	220-223
25230315-7	2014	We show that ganglioside triggered four key pathways leading to apoptosis in human platelets: (i) mitochondrial inner transmembrane potential (DeltaPsim) depolarization; (ii) elevated expression of pro-apoptotic Bax and Bak proteins with reduced expression of anti-apoptotic Bcl-2 protein; (iii) phosphatidylserine exposure and (iv), microparticle formation.	Gangliosides	13-24	BCL2 apoptosis regulator	Homo sapiens	275-280
25230315-8	2014	Inhibition of NAPDH oxidase, PI3K, or PKC rescued platelets from apoptosis induced by Siglec-7 recruitment, suggesting that the platelet receptors P2Y1 and GPIIbIIIa are essential for ganglioside-induced platelet apoptosis.	Gangliosides	184-195	sialic acid binding Ig like lectin 7	Homo sapiens	86-94
25230315-8	2014	Inhibition of NAPDH oxidase, PI3K, or PKC rescued platelets from apoptosis induced by Siglec-7 recruitment, suggesting that the platelet receptors P2Y1 and GPIIbIIIa are essential for ganglioside-induced platelet apoptosis.	Gangliosides	184-195	purinergic receptor P2Y1	Homo sapiens	147-151
25841453-6	2014	These survival benefits were seen in comparison to observation (E1684 trial) and the ganglioside GMK vaccine (E1694 trial).	Gangliosides	85-96	guanylate kinase 1	Homo sapiens	97-100
25253868-6	2014	GluR2-containing AMPARs did not bind GT1b, but bound specifically to another ganglioside, GM1.	Gangliosides	77-88	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	0-5
25253868-6	2014	GluR2-containing AMPARs did not bind GT1b, but bound specifically to another ganglioside, GM1.	Gangliosides	77-88	coenzyme Q10A	Mus musculus	90-93
25413786-3	2014	We report two cases of ganglioside antibody-negative paediatric GBS associated with CASPR2 antibodies.	Gangliosides	23-34	contactin associated protein 2	Homo sapiens	84-90
25101077-5	2014	Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example, as receptors in cell-cell recognition, which can be exploited by viruses and other pathogens, and also by regulating signaling proteins, such as the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR), through lateral interaction in the membrane.	Gangliosides	0-12	epidermal growth factor receptor	Homo sapiens	261-293
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Gangliosides	213-224	synuclein alpha	Homo sapiens	41-56
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Gangliosides	213-224	amyloid beta precursor protein	Homo sapiens	140-145
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Gangliosides	213-224	synuclein alpha	Homo sapiens	169-184
25140899-5	2014	By modulating the amino acid sequence of alpha-synuclein at only two positions in which we introduced a pair of histidine residues found in Abeta, we created a chimeric alpha-synuclein/Abeta peptide with extended ganglioside-binding properties.	Gangliosides	213-224	amyloid beta precursor protein	Homo sapiens	185-190
24934090-7	2014	Interestingly, the inhibition of ganglioside GM3 synthesis by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propranol (D-PDMP) and GM3 synthase-siRNA blocked the CAPE-induced expression of the megakaryocytic markers and differentiation of K562 cells.	Gangliosides	33-44	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	133-145
24821093-11	2014	It has been proposed that the ganglioside GM1 promotes neuronal growth, phenotypic expression, and survival by modulating tyrosine kinase receptors for neurotrophic factors.	Gangliosides	30-41	coenzyme Q10A	Mus musculus	42-45
25101077-5	2014	Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example, as receptors in cell-cell recognition, which can be exploited by viruses and other pathogens, and also by regulating signaling proteins, such as the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR), through lateral interaction in the membrane.	Gangliosides	0-12	epidermal growth factor receptor	Homo sapiens	295-299
25101077-5	2014	Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example, as receptors in cell-cell recognition, which can be exploited by viruses and other pathogens, and also by regulating signaling proteins, such as the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR), through lateral interaction in the membrane.	Gangliosides	0-12	kinase insert domain receptor	Homo sapiens	309-352
25101077-5	2014	Gangliosides perform important functions through carbohydrate-specific interactions with proteins, for example, as receptors in cell-cell recognition, which can be exploited by viruses and other pathogens, and also by regulating signaling proteins, such as the epidermal growth factor receptor (EGFR) and the vascular endothelial growth factor receptor (VEGFR), through lateral interaction in the membrane.	Gangliosides	0-12	kinase insert domain receptor	Homo sapiens	354-359
24947940-1	2014	Ganglioside GM3, a host-derived glycosphingolipid incorporated in the membrane of human immunodeficiency virus-1 (HIV-1) viral particles, mediates interactions between HIV-1 and Siglec1/CD169, a protein expressed on dendritic cells (DCs).	Gangliosides	0-11	sialic acid binding Ig like lectin 1	Homo sapiens	186-191
24534627-5	2014	These findings are consistent with reversible conduction failure in both motor and sensory fibres, and PCB/MFS could be classified in the recently described nodo-paranodopathy spectrum of acute neuropathies associated with anti-ganglioside antibodies.	Gangliosides	228-239	pyruvate carboxylase	Homo sapiens	103-106
24781837-1	2014	The objective of this study was to investigate if the clinical and electrophysiological phenotype of patients with polyneuropathy associated with IgM monoclonal gammopathy (IgM-PNP) is related to the presence of antibodies against gangliosides or myelin-associated glycoprotein (MAG).	Gangliosides	231-243	myelin associated glycoprotein	Homo sapiens	247-277
24781837-1	2014	The objective of this study was to investigate if the clinical and electrophysiological phenotype of patients with polyneuropathy associated with IgM monoclonal gammopathy (IgM-PNP) is related to the presence of antibodies against gangliosides or myelin-associated glycoprotein (MAG).	Gangliosides	231-243	myelin associated glycoprotein	Homo sapiens	279-282
24685176-2	2014	Here, we found that soluble Abeta oligomers were sequestered from brain interstitial fluid onto brain membranes much more rapidly than nontoxic monomers and were recovered in part as bound to GM1 ganglioside on membranes.	Gangliosides	196-207	histocompatibility 2, class II antigen A, beta 1	Mus musculus	28-33
24829158-6	2014	Interestingly, among the gangliosides, CDDP augmented the expression of only GM3 synthase and its product GM3.	Gangliosides	25-37	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	77-89
24658138-4	2014	Of the four known mammalian sialidases, NEU3 has a substrate preference for gangliosides and is expressed at mRNA and protein levels at comparable abundance in epithelia derived from human trachea, bronchi, small airways, and alveoli.	Gangliosides	76-88	neuraminidase 3	Homo sapiens	40-44
24658138-6	2014	Small interfering RNA-induced silencing of NEU3 expression diminished sialidase activity for a ganglioside substrate by >70%.	Gangliosides	95-106	neuraminidase 3	Homo sapiens	43-47
24589479-6	2014	In particular, fluorescence resonance energy transfer (FRET) and coimmunoprecipitation analyses revealed that this ganglioside interacts with phosphatidylinositol 3-phosphate and can be detected in immature autophagosomes in association with LC3-II as well as in autolysosomes associated with LAMP1.	Gangliosides	115-126	lysosomal associated membrane protein 1	Homo sapiens	293-298
24326453-0	2014	Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
24326453-0	2014	Ganglioside GM3 depletion reverses impaired wound healing in diabetic mice by activating IGF-1 and insulin receptors.	Gangliosides	0-11	insulin-like growth factor 1	Mus musculus	89-94
24925219-0	2014	Sialidase NEU3 dynamically associates to different membrane domains specifically modifying their ganglioside pattern and triggering Akt phosphorylation.	Gangliosides	97-108	neuraminidase 3	Homo sapiens	10-14
24925219-5	2014	Sialidase NEU3 shows high enzymatic specificity toward gangliosides.	Gangliosides	55-67	neuraminidase 3	Homo sapiens	10-14
24925219-8	2014	By means of inducible expression cell system we found that i) newly synthesized NEU3 is initially associated to non-DRM; ii) at steady state the protein is equally distributed between the two membrane subcompartments, i.e., DRM and non-DRM; iii) NEU3 is degraded via the proteasomal pathway; iv) the enzyme specifically modifies the ganglioside composition of the membrane areas where it resides; and v) NEU3 triggers phosphorylation of Akt, even in absence of exogenously administered EGF.	Gangliosides	333-344	neuraminidase 3	Homo sapiens	80-84
24925219-9	2014	Taken together our data demonstrate that NEU3 regulates the DRM ganglioside content and it can be considered as a modulator of Akt phosphorylation, further supporting the role of this enzyme in cancer and tumorigenesis.	Gangliosides	64-75	neuraminidase 3	Homo sapiens	41-45
24653215-4	2014	Thin-layer chromatography analysis of glycosphingolipids showed that the amounts of Lac-Cer and ganglioside GM3 are significantly less in clone E5 than in clone C1.	Gangliosides	96-107	granulocyte macrophage antigen 3	Mus musculus	108-111
24500283-10	2014	Addition of GM1 (but not GM3) ganglioside to CFTR-silenced cells restored activated beta1-integrin, pFAK, and pCAS to near control levels and partially restored (~40%) cell migration.	Gangliosides	30-41	myospheroid	Drosophila melanogaster	84-98
24434060-5	2014	This led us to hypothesize that alterations in ganglioside species might contribute to the age-associated loss of PMCA activity.	Gangliosides	47-58	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	114-118
24434060-6	2014	To probe the relationship between changes in endogenous ganglioside content or composition and PMCA activity in membranes of cortical neurons, we induced depletion of gangliosides by treating neurons with d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (d-PDMP).	Gangliosides	56-67	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	95-99
24434060-7	2014	This caused a marked decrease in the activity of PMCA, which suggested a direct correlation between ganglioside content and PMCA activity.	Gangliosides	100-111	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	49-53
24434060-7	2014	This caused a marked decrease in the activity of PMCA, which suggested a direct correlation between ganglioside content and PMCA activity.	Gangliosides	100-111	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	124-128
24434060-10	2014	Our observations add support to previous reports of PMCA regulation by gangliosides by demonstrating that manipulations of endogenous ganglioside content and species affect the activity of PMCA in neuronal membranes.	Gangliosides	71-83	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	52-56
24434060-10	2014	Our observations add support to previous reports of PMCA regulation by gangliosides by demonstrating that manipulations of endogenous ganglioside content and species affect the activity of PMCA in neuronal membranes.	Gangliosides	71-83	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	189-193
24434060-10	2014	Our observations add support to previous reports of PMCA regulation by gangliosides by demonstrating that manipulations of endogenous ganglioside content and species affect the activity of PMCA in neuronal membranes.	Gangliosides	71-82	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	52-56
24434060-10	2014	Our observations add support to previous reports of PMCA regulation by gangliosides by demonstrating that manipulations of endogenous ganglioside content and species affect the activity of PMCA in neuronal membranes.	Gangliosides	71-82	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	189-193
24685176-2	2014	Here, we found that soluble Abeta oligomers were sequestered from brain interstitial fluid onto brain membranes much more rapidly than nontoxic monomers and were recovered in part as bound to GM1 ganglioside on membranes.	Gangliosides	196-207	coenzyme Q10A	Mus musculus	192-195
24685176-3	2014	Abeta oligomers bound strongly to GM1 ganglioside, and blocking the sialic acid residue on GM1 decreased oligomer-mediated LTP impairment in mouse hippocampal slices.	Gangliosides	38-49	histocompatibility 2, class II antigen A, beta 1	Mus musculus	0-5
24685176-3	2014	Abeta oligomers bound strongly to GM1 ganglioside, and blocking the sialic acid residue on GM1 decreased oligomer-mediated LTP impairment in mouse hippocampal slices.	Gangliosides	38-49	coenzyme Q10A	Mus musculus	34-37
24727660-11	2014	In conclusion, we provide the first in vitro evidence that anti-ganglioside GD2 14G2a mAb effectively inhibits cell invasiveness, MMP-2 expression and activity, and cell viability in human OS cells.	Gangliosides	64-75	matrix metallopeptidase 2	Homo sapiens	130-135
24326249-4	2014	Key structural features revealed include galectin-3"s demonstration of a binding mode towards gangliosides distinct from that to the lacto/neolacto-glycosphingolipids, with its capacity for recognising the core beta-galactoside region being challenged when the core oligosaccharide epitope of ganglio-series glycosphingolipids (GM3) is embedded within particular higher-molecular-weight glycans.	Gangliosides	94-106	galectin 3	Homo sapiens	41-51
24658680-4	2014	The ganglioside species were found characterized by a high diversity of the ceramide constitution, an elevated sialylation degree (up to pentasialylated gangliosides-GP1) and sugar cores modified by fucosylation (Fuc) and acetylation (O-Ac).	Gangliosides	4-15	GTP binding protein 1	Homo sapiens	166-169
24658680-4	2014	The ganglioside species were found characterized by a high diversity of the ceramide constitution, an elevated sialylation degree (up to pentasialylated gangliosides-GP1) and sugar cores modified by fucosylation (Fuc) and acetylation (O-Ac).	Gangliosides	153-165	GTP binding protein 1	Homo sapiens	166-169
24523539-7	2014	Ganglioside conversion by Neu3 sialidase further activates the ERK pathway.	Gangliosides	0-11	neuraminidase 3	Rattus norvegicus	26-30
24523539-0	2014	Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons.	Gangliosides	24-35	neuraminidase 3	Rattus norvegicus	0-4
24399479-1	2014	We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides".	Gangliosides	320-332	insulin	Homo sapiens	66-73
24399479-1	2014	We demonstrated the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and GM3 ganglioside in adipocytes and propose a working hypothesis "metabolic disorders, such as type 2 diabetes, are membrane microdomain disorders caused by aberrant expression of gangliosides".	Gangliosides	320-332	insulin receptor	Homo sapiens	121-137
23962659-5	2014	The FO diet also suppressed (P< 0 05) the co-localisation of PKCtheta with ganglioside GM1 (monosialotetrahexosylganglioside), a marker for lipid rafts, which is consistent with previous observations.	Gangliosides	78-89	protein kinase C, theta	Mus musculus	64-72
24478100-7	2014	Using Neuro-2a cells, a mouse neuroblastoma cell line, TeNT HCR (HCR/T) and TeNT(RY) were found to bind gangliosides with similar affinities and specificities, consistent with the HCR domain containing receptor binding function.	Gangliosides	104-116	hypocretin	Mus musculus	60-63
24478100-7	2014	Using Neuro-2a cells, a mouse neuroblastoma cell line, TeNT HCR (HCR/T) and TeNT(RY) were found to bind gangliosides with similar affinities and specificities, consistent with the HCR domain containing receptor binding function.	Gangliosides	104-116	hypocretin	Mus musculus	65-70
24478100-7	2014	Using Neuro-2a cells, a mouse neuroblastoma cell line, TeNT HCR (HCR/T) and TeNT(RY) were found to bind gangliosides with similar affinities and specificities, consistent with the HCR domain containing receptor binding function.	Gangliosides	104-116	hypocretin	Mus musculus	65-68
24184316-0	2014	The ganglioside GQ1b regulates BDNF expression via the NMDA receptor signaling pathway.	Gangliosides	4-15	brain-derived neurotrophic factor	Rattus norvegicus	31-35
24184316-9	2014	Moreover, GQ1b restored the decreased BDNF expression induced by the ganglioside synthesis inhibitor, D-PDMP, in rat primary cortical neurons.	Gangliosides	69-80	brain-derived neurotrophic factor	Rattus norvegicus	38-42
24333297-8	2014	Ganglioside deficiency also led to the induction of matrix metalloproteinase (MMP)-13 and ADAMTS-5 secretion and chondrocyte apoptosis in vitro.	Gangliosides	0-11	matrix metallopeptidase 13	Mus musculus	52-85
24333297-8	2014	Ganglioside deficiency also led to the induction of matrix metalloproteinase (MMP)-13 and ADAMTS-5 secretion and chondrocyte apoptosis in vitro.	Gangliosides	0-11	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	90-98
24333297-10	2014	GSL profiling revealed the presence of abundant gangliosides in chondrocytes after IL-1alpha stimulation.	Gangliosides	48-60	interleukin 1 alpha	Mus musculus	83-92
24333297-11	2014	CONCLUSION: Gangliosides play a critical role in OA pathogenesis by regulating the expression of MMP-13 and ADAMTS-5 and chondrocyte apoptosis.	Gangliosides	12-24	matrix metallopeptidase 13	Mus musculus	97-103
24333297-11	2014	CONCLUSION: Gangliosides play a critical role in OA pathogenesis by regulating the expression of MMP-13 and ADAMTS-5 and chondrocyte apoptosis.	Gangliosides	12-24	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2)	Mus musculus	108-116
23999868-1	2014	The ganglioside GM4 is a sialic acid-containing glycosphingolipid mainly expressed in mammalian brain and erythrocytes.	Gangliosides	4-15	T cell receptor alpha variable 6-3	Mus musculus	16-19
23999868-2	2014	GM4 is synthesized by the sialylation of galactosylceramide (GalCer), while the ganglioside GM3 is synthesized by the sialylation of lactosylceramide (LacCer).	Gangliosides	80-91	granulocyte macrophage antigen 3	Mus musculus	92-95
24026681-0	2014	A mutation in a ganglioside biosynthetic enzyme, ST3GAL5, results in salt & pepper syndrome, a neurocutaneous disorder with altered glycolipid and glycoprotein glycosylation.	Gangliosides	16-27	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Danio rerio	49-56
24026681-6	2014	The ST3GAL5 enzyme synthesizes ganglioside GM3, a glycosophingolipid enriched in neural tissue, by adding sialic acid to lactosylceramide.	Gangliosides	31-42	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Danio rerio	4-11
24026681-9	2014	Comprehensive glycomic analysis of N-linked, O-linked and GSL glycans revealed collateral alterations in response to loss of complex gangliosides in patient fibroblasts and in zebrafish embryos injected with antisense morpholinos that targeted zebrafish st3gal5 expression.	Gangliosides	133-145	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Danio rerio	254-261
24977484-2	2014	Here we addressed a potential function of gamma-secretase (presenilin) dependent cleavage of the amyloid-precursor-protein (APP) in the regulation of ganglioside de novo synthesis.	Gangliosides	150-161	amyloid beta (A4) precursor protein	Mus musculus	97-122
24431446-3	2014	Mice lacking complex gangliosides attributable to targeted ablation of the B4galnt1 gene that encodes beta-1,4-N-acetylegalactosaminyltransferase 1 (GalNAc-transferase; GalNAcT(-/-)) develop normally before exhibiting an age-dependent neurodegenerative phenotype characterized by marked behavioral abnormalities, central and peripheral axonal degeneration, reduced myelin volume, and loss of axo-glial junction integrity.	Gangliosides	21-33	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	75-83
24431446-6	2014	Complex gangliosides, as assessed by thin-layer chromatography, mass spectrometry, GalNAcT enzyme activity, and anti-ganglioside antibody (AgAb) immunohistology, were restored in both neuronal and glial GalNAcT rescue mice.	Gangliosides	8-20	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	83-90
24431446-6	2014	Complex gangliosides, as assessed by thin-layer chromatography, mass spectrometry, GalNAcT enzyme activity, and anti-ganglioside antibody (AgAb) immunohistology, were restored in both neuronal and glial GalNAcT rescue mice.	Gangliosides	8-20	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	203-210
24431446-6	2014	Complex gangliosides, as assessed by thin-layer chromatography, mass spectrometry, GalNAcT enzyme activity, and anti-ganglioside antibody (AgAb) immunohistology, were restored in both neuronal and glial GalNAcT rescue mice.	Gangliosides	8-19	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	83-90
24431446-6	2014	Complex gangliosides, as assessed by thin-layer chromatography, mass spectrometry, GalNAcT enzyme activity, and anti-ganglioside antibody (AgAb) immunohistology, were restored in both neuronal and glial GalNAcT rescue mice.	Gangliosides	8-19	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	203-210
24214972-7	2014	For example, either ganglioside addition or human glucosylceramide synthase overexpression suppresses insulin signaling in adipocytes.	Gangliosides	20-31	insulin	Homo sapiens	102-109
24372645-0	2014	Ganglioside GD3 induces convergence and synergism of adhesion and hepatocyte growth factor/Met signals in melanomas.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
24372645-1	2014	Ganglioside GD3 is highly expressed in human melanomas and enhances malignant properties of melanomas, such as cell proliferation and invasion activity.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
24103911-0	2013	Mutations in B4GALNT1 (GM2 synthase) underlie a new disorder of ganglioside biosynthesis.	Gangliosides	64-75	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	13-21
24077583-9	2014	Immunohistochemistry for ganglioside GM3, another disease marker, showed reversal of neuronal inclusions in areas with IDUA co-expression in both delivery methods.	Gangliosides	25-36	iduronidase, alpha-L	Mus musculus	119-123
24120649-2	2014	In this study, we show that ganglioside GM3 inhibits the VEGF-induced expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) through activation of nuclear factor-kappaB (NF-kappaB) via protein kinase B (AKT) signaling in human umbilical vein endothelial cells (HUVECs), relating with leukocyte recruitment to endothelial cells under inflammatory conditions.	Gangliosides	28-39	granulocyte macrophage antigen 3	Mus musculus	40-43
24120649-2	2014	In this study, we show that ganglioside GM3 inhibits the VEGF-induced expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) through activation of nuclear factor-kappaB (NF-kappaB) via protein kinase B (AKT) signaling in human umbilical vein endothelial cells (HUVECs), relating with leukocyte recruitment to endothelial cells under inflammatory conditions.	Gangliosides	28-39	vascular endothelial growth factor A	Homo sapiens	57-61
24120649-2	2014	In this study, we show that ganglioside GM3 inhibits the VEGF-induced expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) through activation of nuclear factor-kappaB (NF-kappaB) via protein kinase B (AKT) signaling in human umbilical vein endothelial cells (HUVECs), relating with leukocyte recruitment to endothelial cells under inflammatory conditions.	Gangliosides	28-39	intercellular adhesion molecule 1	Homo sapiens	84-117
24120649-2	2014	In this study, we show that ganglioside GM3 inhibits the VEGF-induced expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) through activation of nuclear factor-kappaB (NF-kappaB) via protein kinase B (AKT) signaling in human umbilical vein endothelial cells (HUVECs), relating with leukocyte recruitment to endothelial cells under inflammatory conditions.	Gangliosides	28-39	intercellular adhesion molecule 1	Homo sapiens	119-125
24120649-2	2014	In this study, we show that ganglioside GM3 inhibits the VEGF-induced expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) through activation of nuclear factor-kappaB (NF-kappaB) via protein kinase B (AKT) signaling in human umbilical vein endothelial cells (HUVECs), relating with leukocyte recruitment to endothelial cells under inflammatory conditions.	Gangliosides	28-39	vascular cell adhesion molecule 1	Homo sapiens	131-164
24120649-2	2014	In this study, we show that ganglioside GM3 inhibits the VEGF-induced expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) through activation of nuclear factor-kappaB (NF-kappaB) via protein kinase B (AKT) signaling in human umbilical vein endothelial cells (HUVECs), relating with leukocyte recruitment to endothelial cells under inflammatory conditions.	Gangliosides	28-39	vascular cell adhesion molecule 1	Homo sapiens	166-172
24120649-2	2014	In this study, we show that ganglioside GM3 inhibits the VEGF-induced expression of intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) through activation of nuclear factor-kappaB (NF-kappaB) via protein kinase B (AKT) signaling in human umbilical vein endothelial cells (HUVECs), relating with leukocyte recruitment to endothelial cells under inflammatory conditions.	Gangliosides	28-39	AKT serine/threonine kinase 1	Homo sapiens	252-255
24102378-6	2014	Moreover, epigenetic activation of GalNAcT was also detected, as accompanied by a pronounced induction of neural differentiation in primary neuroepithelium culture responding to an exogenous supplement of ganglioside GM1, a downstream product of the gene"s encoding enzyme.	Gangliosides	205-216	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	35-42
24103911-4	2013	This disease, because of defects in the first step of ganglioside biosynthesis (GM3 synthase), results in a severe epileptic disorder found at high frequency amongst the Old Order Amish.	Gangliosides	54-65	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	80-92
24103911-6	2013	Our genetic studies identified mutations in B4GALNT1 (GM2 synthase), encoding the enzyme that catalyzes the second step in complex ganglioside biosynthesis, as the cause of this neurodegenerative phenotype.	Gangliosides	131-142	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	44-52
23968914-0	2013	Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway.	Gangliosides	65-77	epidermal growth factor receptor	Mus musculus	93-97
24198336-0	2013	Interaction of ganglioside GD3 with an EGF receptor sustains the self-renewal ability of mouse neural stem cells in vitro.	Gangliosides	15-26	epidermal growth factor receptor	Mus musculus	39-51
24152915-4	2013	A relationship between gangliosides and epidermal growth factor receptor (EGFR) activation during osteoblastic differentiation of hMSCs was observed, and the gangliosides may play a major role in the regulation of the differentiation.	Gangliosides	23-35	epidermal growth factor receptor	Homo sapiens	40-72
24152915-4	2013	A relationship between gangliosides and epidermal growth factor receptor (EGFR) activation during osteoblastic differentiation of hMSCs was observed, and the gangliosides may play a major role in the regulation of the differentiation.	Gangliosides	23-35	epidermal growth factor receptor	Homo sapiens	74-78
23968914-0	2013	Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway.	Gangliosides	65-77	met proto-oncogene	Mus musculus	101-105
23968914-0	2013	Synergistic inhibition of cell migration by tetraspanin CD82 and gangliosides occurs via the EGFR or cMet-activated Pl3K/Akt signalling pathway.	Gangliosides	65-77	thymoma viral proto-oncogene 1	Mus musculus	121-124
23995055-0	2013	Improvement of spontaneous alternation behavior deficit by activation of alpha4beta2 nicotinic acetylcholine receptor signaling in the ganglioside GM3-deficient mice.	Gangliosides	135-146	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	85-117
24136227-9	2013	These results provide a key mechanism for TRAIL sensitivity in B-cell malignances: the association, within lipid microdomains, of DR4 but not DR5, with a specific ganglioside, that is the monosialoganglioside GM3.	Gangliosides	163-174	TNF superfamily member 10	Homo sapiens	42-47
24136227-9	2013	These results provide a key mechanism for TRAIL sensitivity in B-cell malignances: the association, within lipid microdomains, of DR4 but not DR5, with a specific ganglioside, that is the monosialoganglioside GM3.	Gangliosides	163-174	TNF receptor superfamily member 10a	Homo sapiens	130-133
23547010-3	2013	We have previously described a GM3(Neu5Gc) ganglioside-specific mAb, named 14F7, with the ability to kill tumor cells in a complement-independent manner.	Gangliosides	43-54	granulocyte macrophage antigen 3	Mus musculus	31-34
23749170-0	2013	Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
23749170-0	2013	Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.	Gangliosides	0-11	hepatocyte growth factor	Mus musculus	25-28
23749170-0	2013	Ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.	Gangliosides	0-11	met proto-oncogene	Mus musculus	109-113
23749170-1	2013	Ganglioside GM3 plays a well-documented and important role in the regulation of tumor cell proliferation, invasion, and metastasis by modulating tyrosine kinase growth factor receptors.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
23749170-4	2013	Decreasing GM3 expression with the use of P4, a specific inhibitor for ganglioside synthesis inhibited the HGF-stimulated phosphorylation of cMet and activity of PI3K/Akt signaling pathway.	Gangliosides	71-82	granulocyte macrophage antigen 3	Mus musculus	11-14
23749170-4	2013	Decreasing GM3 expression with the use of P4, a specific inhibitor for ganglioside synthesis inhibited the HGF-stimulated phosphorylation of cMet and activity of PI3K/Akt signaling pathway.	Gangliosides	71-82	hepatocyte growth factor	Mus musculus	107-110
23749170-4	2013	Decreasing GM3 expression with the use of P4, a specific inhibitor for ganglioside synthesis inhibited the HGF-stimulated phosphorylation of cMet and activity of PI3K/Akt signaling pathway.	Gangliosides	71-82	met proto-oncogene	Mus musculus	141-145
23749170-4	2013	Decreasing GM3 expression with the use of P4, a specific inhibitor for ganglioside synthesis inhibited the HGF-stimulated phosphorylation of cMet and activity of PI3K/Akt signaling pathway.	Gangliosides	71-82	thymoma viral proto-oncogene 1	Mus musculus	167-170
23749170-7	2013	All the observations indicate that ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.	Gangliosides	35-46	granulocyte macrophage antigen 3	Mus musculus	47-50
23749170-7	2013	All the observations indicate that ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.	Gangliosides	35-46	hepatocyte growth factor	Mus musculus	60-63
23749170-7	2013	All the observations indicate that ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.	Gangliosides	35-46	met proto-oncogene	Mus musculus	144-148
23749170-7	2013	All the observations indicate that ganglioside GM3 promotes HGF-stimulated motility of murine hepatoma cell through enhanced phosphorylation of cMet at specific tyrosine sites and PI3K/Akt-mediated migration signaling.	Gangliosides	35-46	thymoma viral proto-oncogene 1	Mus musculus	185-188
24098718-2	2013	The same four closely related structures, GM1, GD1a, GD1b and GT1b, comprise the majority of total brain gangliosides in mammals and birds.	Gangliosides	105-117	coenzyme Q10A	Mus musculus	42-45
24098718-8	2013	These findings are considered in relationship to the hypothesis that gangliosides GD1a and GT1b act as receptors for an important axon-myelin recognition protein, myelin-associated glycoprotein (MAG).	Gangliosides	69-81	myelin-associated glycoprotein	Mus musculus	163-193
24098718-8	2013	These findings are considered in relationship to the hypothesis that gangliosides GD1a and GT1b act as receptors for an important axon-myelin recognition protein, myelin-associated glycoprotein (MAG).	Gangliosides	69-81	myelin-associated glycoprotein	Mus musculus	195-198
23774686-6	2013	To elucidate this, we evaluated gene expression of ganglioside synthesis (GM3, GD3 and GM2/GD2 synthases) and degradation of (Neuraminidase1) enzymes in the cerebellum and hippocampus by RT-sq-PCR.	Gangliosides	51-62	granulocyte macrophage antigen 3	Mus musculus	74-77
23774686-6	2013	To elucidate this, we evaluated gene expression of ganglioside synthesis (GM3, GD3 and GM2/GD2 synthases) and degradation of (Neuraminidase1) enzymes in the cerebellum and hippocampus by RT-sq-PCR.	Gangliosides	51-62	cytochrome b5 domain containing 2	Mus musculus	87-90
23233133-5	2013	In the TCR-dependent activation, CD4(+) T cells selectively require a-series gangliosides, but CD8(+) T cells do require only o-series gangliosides but not a-series gangliosides.	Gangliosides	77-89	CD4 antigen	Mus musculus	33-36
23233133-6	2013	Ganglioside GM3 synthase-deficient mice lacking a-series gangliosides neither exhibited the TCR-dependent activation of CD4(+) T nor developed ovalbumin-induced allergic airway inflammation.	Gangliosides	57-69	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-24
23233133-7	2013	These findings imply that the distinct expression pattern of ganglioside species in CD4(+) and CD8(+) T cells define the immune function of each T cell subset.	Gangliosides	61-72	CD4 antigen	Mus musculus	84-87
23924792-2	2013	A novel recombinant immunotoxin, DmAb14m-(scFv)-PE38KDEL (DmAb14m-IT), specific for the gangliosides 3"-isoLM1 and 3",6"-isoLD1, was constructed with improved affinity and increased cytotoxicity for immunotherapeutic targeting of glioblastoma.	Gangliosides	88-100	immunglobulin heavy chain variable region	Homo sapiens	42-46
23995055-1	2013	We have reported that in ganglioside GM3-deficient (GM3(-/-)) mice, spontaneous alternation behavior assessed by a Y-maze task was significantly lower, and total arm entries were significantly higher than in wild-type mice.	Gangliosides	25-36	granulocyte macrophage antigen 3	Mus musculus	37-40
23995055-11	2013	Thus, the ganglioside GM3 might be responsible for alpha4beta2 nAChR signaling in the spontaneous alternation behavior.	Gangliosides	10-21	granulocyte macrophage antigen 3	Mus musculus	22-25
23995055-11	2013	Thus, the ganglioside GM3 might be responsible for alpha4beta2 nAChR signaling in the spontaneous alternation behavior.	Gangliosides	10-21	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	63-68
23746551-7	2013	B4GALNT1 encodes beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4GALNT1), involved in ganglioside biosynthesis.	Gangliosides	88-99	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	0-8
23688073-1	2013	Accumulation and fibril formation of amyloid beta (Abeta) peptides onto a ganglioside-rich lipid membrane is a cause of neuro-disturbance diseases.	Gangliosides	74-85	amyloid beta precursor protein	Homo sapiens	51-56
23746551-7	2013	B4GALNT1 encodes beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4GALNT1), involved in ganglioside biosynthesis.	Gangliosides	88-99	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	17-63
23746551-7	2013	B4GALNT1 encodes beta-1,4-N-acetyl-galactosaminyl transferase 1 (B4GALNT1), involved in ganglioside biosynthesis.	Gangliosides	88-99	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	65-73
23355442-0	2013	Ganglioside GM3 inhibits hepatoma cell motility via down-regulating activity of EGFR and PI3K/AKT signaling pathway.	Gangliosides	0-11	Epidermal growth factor receptor	Drosophila melanogaster	80-84
23670557-5	2013	Using structural studies and the known entry properties of BoNT/A, an HCR subunit vaccine against BoNT/A that contained the point mutation W1266A within the ganglioside binding pocket was designed.	Gangliosides	157-168	coiled-coil alpha-helical rod protein 1	Mus musculus	70-73
23565921-3	2013	Cholinergic neuron-specific gangliosides, such as GT1aalpha and GQ1balpha, were elevated in the brains of double-Tg mice (APP/PSEN1), as compared with those of WT mice.	Gangliosides	28-40	presenilin 1	Mus musculus	126-131
23401234-11	2013	In summary, the rate of mNT regeneration following anti-ganglioside antibody and complement-mediated injury does not differ majorly between young adult and aged mice irrespective of the expression of particular gangliosides.	Gangliosides	56-67	max binding protein	Mus musculus	24-27
23785136-3	2013	Inherited defects in ganglioside biosynthesis causing fatal neurodegenerative diseases have been described so far almost exclusively in mouse models, whereas inherited defects in ganglioside catabolism causing various clinical forms of GM1- and GM2-gangliosidoses have long been known.	Gangliosides	179-190	coenzyme Q10A	Mus musculus	236-239
23785136-3	2013	Inherited defects in ganglioside biosynthesis causing fatal neurodegenerative diseases have been described so far almost exclusively in mouse models, whereas inherited defects in ganglioside catabolism causing various clinical forms of GM1- and GM2-gangliosidoses have long been known.	Gangliosides	179-190	cytochrome b5 domain containing 2	Mus musculus	245-248
25470923-7	2013	The suggestion is put forward that the pronounced diminution of toxic effect of LPS on PC12 cells by gangliosides may be explained by the alteration of structural organization of lipid rafts caused by the incorporation of exogenous gangliosides in cell plasma membranes, which diminishes the translocation of TLR4 receptor into the rafts and their activation by LPS.	Gangliosides	101-113	toll-like receptor 4	Rattus norvegicus	309-313
25470923-7	2013	The suggestion is put forward that the pronounced diminution of toxic effect of LPS on PC12 cells by gangliosides may be explained by the alteration of structural organization of lipid rafts caused by the incorporation of exogenous gangliosides in cell plasma membranes, which diminishes the translocation of TLR4 receptor into the rafts and their activation by LPS.	Gangliosides	232-244	toll-like receptor 4	Rattus norvegicus	309-313
23529622-10	2013	As C. jejuni strains expressing ganglioside mimics GD1a and GM1a are closely associated with GBS, Sn binding may be a determining event in the production of cross-reactive antibodies and the development of GBS.	Gangliosides	32-43	fascin actin-bundling protein 1	Homo sapiens	98-100
23565921-0	2013	Brain gangliosides of a transgenic mouse model of Alzheimer"s disease with deficiency in GD3-synthase: expression of elevated levels of a cholinergic-specific ganglioside, GT1aalpha.	Gangliosides	6-18	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	89-101
23565921-6	2013	Thus, the disruption of the gene of a specific ganglioside-synthase, GD3S, altered the expression of cholinergic neuron-specific gangliosides.	Gangliosides	47-58	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	69-73
23565921-6	2013	Thus, the disruption of the gene of a specific ganglioside-synthase, GD3S, altered the expression of cholinergic neuron-specific gangliosides.	Gangliosides	129-141	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	69-73
23565921-7	2013	Our data thus suggest the intriguing possibility that the elevated cholinergic-specific ganglioside, GT1aalpha, in the triple mutant mouse brains (APP/PSEN1/GD3S(-/-)) may contribute to the memory retention in these mice.	Gangliosides	88-99	presenilin 1	Mus musculus	151-156
23565921-7	2013	Our data thus suggest the intriguing possibility that the elevated cholinergic-specific ganglioside, GT1aalpha, in the triple mutant mouse brains (APP/PSEN1/GD3S(-/-)) may contribute to the memory retention in these mice.	Gangliosides	88-99	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	157-161
23363739-1	2013	Human sialidase 2 (NEU2) is a cytoplasmic sialidase that degrades sialylglycoconjugates, including glycoproteins and gangliosides, via hydrolysis of terminal sialic acids to produce asialo-type molecules.	Gangliosides	117-129	neuraminidase 2	Homo sapiens	6-17
22990144-4	2013	GM3 synthase catalyzes the formation of GM3 ganglioside from lactosylceramide, which is the first step in the synthesis of complex ganglioside species.	Gangliosides	44-55	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
23580005-0	2013	Bovine lactoferrin decreases cholera-toxin-induced intestinal fluid accumulation in mice by ganglioside interaction.	Gangliosides	92-103	lactotransferrin	Mus musculus	7-18
23667543-3	2013	Also, fluvastatin reduced ganglioside M1 rafts formation triggered through the engagement of NK cell activating receptors as FcgammaRIIIA (CD16), NKG2D and DNAM1.	Gangliosides	26-37	Fc gamma receptor IIIa	Homo sapiens	125-137
23667543-3	2013	Also, fluvastatin reduced ganglioside M1 rafts formation triggered through the engagement of NK cell activating receptors as FcgammaRIIIA (CD16), NKG2D and DNAM1.	Gangliosides	26-37	Fc gamma receptor IIIa	Homo sapiens	139-143
23667543-3	2013	Also, fluvastatin reduced ganglioside M1 rafts formation triggered through the engagement of NK cell activating receptors as FcgammaRIIIA (CD16), NKG2D and DNAM1.	Gangliosides	26-37	killer cell lectin like receptor K1	Homo sapiens	146-151
23667543-3	2013	Also, fluvastatin reduced ganglioside M1 rafts formation triggered through the engagement of NK cell activating receptors as FcgammaRIIIA (CD16), NKG2D and DNAM1.	Gangliosides	26-37	CD226 molecule	Homo sapiens	156-161
23626833-1	2013	Recent data have underlined a possible role of G(D3) synthase (GD3S) and complex gangliosides in Estrogen Receptor (ER) negative breast cancer progression.	Gangliosides	81-93	estrogen receptor 1	Homo sapiens	97-114
23363739-1	2013	Human sialidase 2 (NEU2) is a cytoplasmic sialidase that degrades sialylglycoconjugates, including glycoproteins and gangliosides, via hydrolysis of terminal sialic acids to produce asialo-type molecules.	Gangliosides	117-129	neuraminidase 2	Homo sapiens	19-23
23417430-2	2013	Deficiency in this enzyme leads to excessive accumulation of ganglioside GM2 and its asialo derivative, GA2, in brain and visceral tissues.	Gangliosides	61-72	cytochrome b5 domain containing 2	Mus musculus	73-76
23052481-7	2013	Blocking of ganglioside synthesis with a glucosylceramide synthase inhibitor abrogated the increased ADCC response but had no effect on the AICC, indicating that GD2 induced by 4-HPR mediates the sensitization of NB cells for ADCC.	Gangliosides	12-23	haptoglobin-related protein	Homo sapiens	179-182
23417430-3	2013	Small molecule inhibitors of ceramide-specific glucosyltransferase, the first committed step in ganglioside biosynthesis, reduce storage of GM2 and GA2.	Gangliosides	96-107	cytochrome b5 domain containing 2	Mus musculus	140-143
23294326-2	2013	We previously found that the ganglioside-enriched microdomains (ganglioside clusters) in presynaptic neuronal membranes play a key role in the initiation of the Abeta assembly process.	Gangliosides	29-40	amyloid beta (A4) precursor protein	Mus musculus	161-166
23220479-5	2013	On the other hand, when enzyme reactions by alpha2-6STs were performed using substrates GA2 and GA1, very unique gangliosides were generated.	Gangliosides	113-125	electron transfer flavoprotein subunit alpha	Homo sapiens	88-91
23433359-1	2013	BACKGROUND: Niemann Pick C (NPC) disease is a neurovisceral lysosomal storage disorder due to mutations in NPC1 or NPC2 genes, characterized by the accumulation of endocytosed unesterified cholesterol, gangliosides and other lipids within the lysosomes/late endosomes.	Gangliosides	202-214	NPC intracellular cholesterol transporter 1	Homo sapiens	107-111
23433359-1	2013	BACKGROUND: Niemann Pick C (NPC) disease is a neurovisceral lysosomal storage disorder due to mutations in NPC1 or NPC2 genes, characterized by the accumulation of endocytosed unesterified cholesterol, gangliosides and other lipids within the lysosomes/late endosomes.	Gangliosides	202-214	NPC intracellular cholesterol transporter 2	Homo sapiens	115-119
23294326-2	2013	We previously found that the ganglioside-enriched microdomains (ganglioside clusters) in presynaptic neuronal membranes play a key role in the initiation of the Abeta assembly process.	Gangliosides	64-75	amyloid beta (A4) precursor protein	Mus musculus	161-166
23294326-3	2013	However, not all ganglioside clusters accelerate Abeta assembly.	Gangliosides	17-28	amyloid beta (A4) precursor protein	Mus musculus	49-54
23294326-5	2013	The Abeta assembly was generated on a distinctive GM1 domain, which was characterized as the Abeta-sensitive ganglioside nanocluster (ASIGN).	Gangliosides	109-120	amyloid beta (A4) precursor protein	Mus musculus	4-9
23294326-5	2013	The Abeta assembly was generated on a distinctive GM1 domain, which was characterized as the Abeta-sensitive ganglioside nanocluster (ASIGN).	Gangliosides	109-120	amyloid beta (A4) precursor protein	Mus musculus	93-98
23294326-7	2013	These results suggest that ganglioside-bound Abeta (GAbeta), which acts as an endogenous seed for Abeta fibril formation in AD brains, is generated on ASIGN on synaptosomal membranes.	Gangliosides	27-38	amyloid beta (A4) precursor protein	Mus musculus	45-50
23294326-7	2013	These results suggest that ganglioside-bound Abeta (GAbeta), which acts as an endogenous seed for Abeta fibril formation in AD brains, is generated on ASIGN on synaptosomal membranes.	Gangliosides	27-38	amyloid beta (A4) precursor protein	Mus musculus	53-58
23035659-0	2013	Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones.	Gangliosides	15-27	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Rattus norvegicus	46-49
22845664-3	2013	Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1.	Gangliosides	146-157	phosphate cytidylyltransferase 1B, choline	Homo sapiens	89-112
22845664-3	2013	Retinoid analogs have been shown to modulate ceramide levels in the cell membrane, while cholera toxin B subunit (CT-B) specifically binds to the ganglioside GM1.	Gangliosides	146-157	phosphate cytidylyltransferase 1B, choline	Homo sapiens	114-118
23032629-1	2013	Mammalian Neu3 sialidases are involved in various biological processes, such as cell death and differentiation, through desialylation of gangliosides.	Gangliosides	137-149	sialidase-3	Oryzias latipes	10-14
23032629-7	2013	When each gene was transfected into HEK293 to allow cell lysates for the use of enzymatic characterization, two Neu3 sialidases showed strict substrate specificity toward gangliosides, similar to mammalian Neu3.	Gangliosides	171-183	neuraminidase 3	Homo sapiens	112-116
23032629-7	2013	When each gene was transfected into HEK293 to allow cell lysates for the use of enzymatic characterization, two Neu3 sialidases showed strict substrate specificity toward gangliosides, similar to mammalian Neu3.	Gangliosides	171-183	neuraminidase 3	Homo sapiens	206-210
23173866-5	2013	Using a well-defined GBS/MFS-associated C. jejuni strain collection, which included three sialic acid knockout strains, we found that Siglec-7 exclusively binds to C. jejuni strains that express terminal disialylated ganglioside mimics.	Gangliosides	217-228	sialic acid binding Ig like lectin 7	Homo sapiens	134-142
23209287-1	2013	NEU3 sialidase, a key enzyme in ganglioside metabolism, is activated under hypoxic conditions in cultured skeletal muscle cells (C2C12).	Gangliosides	32-43	neuraminidase 3	Homo sapiens	0-4
23035659-0	2013	Involvement of gangliosides in the process of Cbp/PAG phosphorylation by Lyn in developing cerebellar growth cones.	Gangliosides	15-27	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	73-76
23035659-2	2013	The monoclonal antibody to the ganglioside GD3 (R24) immunoprecipitated the Csk (C-terminal src kinase)-binding protein (Cbp).	Gangliosides	31-42	C-terminal Src kinase	Rattus norvegicus	76-79
23035659-2	2013	The monoclonal antibody to the ganglioside GD3 (R24) immunoprecipitated the Csk (C-terminal src kinase)-binding protein (Cbp).	Gangliosides	31-42	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Rattus norvegicus	121-124
23035659-10	2013	These results suggest that Cbp functionally associates with gangliosides on growth cone rafts in developing cerebella.	Gangliosides	60-72	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Rattus norvegicus	27-30
23050851-0	2013	Ganglioside GM3 participates in the TGF-beta1-induced epithelial-mesenchymal transition of human lens epithelial cells.	Gangliosides	0-11	transforming growth factor beta 1	Homo sapiens	36-45
23775688-0	2013	The driving force of alpha-synuclein insertion and amyloid channel formation in the plasma membrane of neural cells: key role of ganglioside- and cholesterol-binding domains.	Gangliosides	129-140	synuclein alpha	Homo sapiens	21-36
23775688-7	2013	The driving force of the insertion process is the formation of a transient OH-Pi hydrogen bond between the ganglioside and the aromatic ring of the alpha-synuclein residue Tyr-39.	Gangliosides	107-118	synuclein alpha	Homo sapiens	148-163
23050851-3	2013	However, the relationship between ganglioside GM3 and TGF-beta-induced EMT in the HLE B-3 cells is poorly understood.	Gangliosides	34-45	transforming growth factor beta 1	Homo sapiens	54-62
23050851-4	2013	In the present study we demonstrated that ganglioside GM3 was involved in TGF-beta1-induced EMT in HLE B-3 cells.	Gangliosides	42-53	transforming growth factor beta 1	Homo sapiens	74-83
23050851-5	2013	Our results indicated that the expression of ganglioside GM3 and GM3 synthase mRNA were significantly increased in TGF-beta1-induced HLE B-3 cells.	Gangliosides	45-56	transforming growth factor beta 1	Homo sapiens	115-124
23050851-7	2013	Interestingly, the inhibition of ganglioside GM3 expression by d-PDMP [d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol] and GM3 synthase shRNA (short hairpin RNA) resulted significantly in the suppression of cell migration and EMT-related signalling in HLE B-3 cells stimulated by TGF-beta.	Gangliosides	33-44	transforming growth factor beta 1	Homo sapiens	290-298
23050851-8	2013	Furthermore, exogenous treatment of ganglioside GM3 rescued the expression of EMT molecules and cell migration suppressed by the depletion of ganglioside GM3 in TGF-beta1-induced HLE B-3 cells.	Gangliosides	36-47	transforming growth factor beta 1	Homo sapiens	161-170
23050851-8	2013	Furthermore, exogenous treatment of ganglioside GM3 rescued the expression of EMT molecules and cell migration suppressed by the depletion of ganglioside GM3 in TGF-beta1-induced HLE B-3 cells.	Gangliosides	142-153	transforming growth factor beta 1	Homo sapiens	161-170
23050851-9	2013	We also found that ganglioside GM3 interacted with TGFbetaRs (TGF-beta receptors) in TGF-beta1-induced HLE B-3 cells.	Gangliosides	19-30	transforming growth factor beta 1	Homo sapiens	62-70
23050851-9	2013	We also found that ganglioside GM3 interacted with TGFbetaRs (TGF-beta receptors) in TGF-beta1-induced HLE B-3 cells.	Gangliosides	19-30	transforming growth factor beta 1	Homo sapiens	85-94
23050851-10	2013	Taken together, these results suggest that ganglioside GM3 induced by TGF-beta1 regulates EMT by potential interaction with TGFbetaRs.	Gangliosides	43-54	transforming growth factor beta 1	Homo sapiens	70-79
23108456-8	2013	By measuring fluorescence resonance energy transfer, we found that Lamp-1 (lysosome membrane marker protein) and ganglioside G(M1) (MR marker) were trafficking together in Smpd1 (+/+) CAECs, which was absent in Smpd1 (-/-) CAECs.	Gangliosides	113-124	sphingomyelin phosphodiesterase 1, acid lysosomal	Mus musculus	172-177
24391082-4	2013	Using the microantibody as a library scaffold, we have constructed a phage-display library to successfully isolate molecular-targeting peptides against a cytokine receptor (granulocyte colony-stimulating factor receptor), a protein kinase (Aurora-A), and a ganglioside (GM1).	Gangliosides	257-268	aurora kinase A	Homo sapiens	240-248
23555611-4	2013	The brain-abundant gangliosides GT1b and GQ1b were specifically recognized by the platelets and this recognition involved multiple receptors with P-selectin (CD62P) playing the central role.	Gangliosides	19-31	selectin, platelet	Mus musculus	146-156
23135722-3	2013	The role of gangliosides in rotavirus cell entry was studied by silencing the expression of two key enzymes involved in their biosynthesis--the UDP-glucose:ceramide glucosyltransferase (UGCG), which transfers a glucose molecule to ceramide to produce glucosylceramide GlcCer, and the lactosyl ceramide-alpha-2,3-sialyl transferase 5 (GM3-s), which adds the first SA to lactoceramide-producing ganglioside GM3.	Gangliosides	12-24	UDP-glucose ceramide glucosyltransferase	Homo sapiens	144-184
23135722-3	2013	The role of gangliosides in rotavirus cell entry was studied by silencing the expression of two key enzymes involved in their biosynthesis--the UDP-glucose:ceramide glucosyltransferase (UGCG), which transfers a glucose molecule to ceramide to produce glucosylceramide GlcCer, and the lactosyl ceramide-alpha-2,3-sialyl transferase 5 (GM3-s), which adds the first SA to lactoceramide-producing ganglioside GM3.	Gangliosides	12-23	UDP-glucose ceramide glucosyltransferase	Homo sapiens	144-184
23554574-4	2013	As a major mechanism of central nervous system (CNS) metabolic control, we demonstrate that GCS-derived gangliosides interacting with leptin receptors (ObR) in the neuronal membrane modulate leptin-stimulated formation of signaling metabolites in hypothalamic neurons.	Gangliosides	104-116	UDP-glucose ceramide glucosyltransferase	Mus musculus	92-95
23554574-5	2013	Furthermore, ganglioside-depleted hypothalamic neurons fail to adapt their activity (c-Fos) in response to alterations in peripheral energy signals.	Gangliosides	13-24	FBJ osteosarcoma oncogene	Mus musculus	85-90
23554574-7	2013	Recombinant adeno-associated virus (rAAV)-mediated Ugcg delivery to the arcuate nucleus (Arc) significantly ameliorated obesity, specifying gangliosides as seminal components for hypothalamic regulation of body energy homeostasis.	Gangliosides	140-152	UDP-glucose ceramide glucosyltransferase	Mus musculus	51-55
23117335-0	2013	Effect of tumor gangliosides on tyrosine phosphorylation of p125FAK             in platelet adhesion to collagen.	Gangliosides	16-28	protein tyrosine kinase 2	Homo sapiens	60-67
23117335-9	2013	These results indicate that the tumor gangliosides             enhance platelet adhesion to extracellular matrix collagen by upregulating integrin             alpha2beta1-mediated tyrosine phosphorylation of p125FAK, thereby providing insight into             how this interaction may be involved in neuroblastoma metastasis.	Gangliosides	38-50	protein tyrosine kinase 2	Homo sapiens	208-215
23555611-4	2013	The brain-abundant gangliosides GT1b and GQ1b were specifically recognized by the platelets and this recognition involved multiple receptors with P-selectin (CD62P) playing the central role.	Gangliosides	19-31	selectin, platelet	Mus musculus	158-163
23696738-8	2013	These findings show that FGFR3 plays a pivotal role in the specific uptake of BoNT/A across the cell membrane being part of a larger receptor complex involving ganglioside- and protein-protein interactions.	Gangliosides	160-171	fibroblast growth factor receptor 3	Homo sapiens	25-30
23383290-2	2013	This deficiency results in aberrant lysosomal accumulation of the ganglioside GM2 and related glycolipids, and progressive deterioration of the central nervous system.	Gangliosides	66-77	cytochrome b5 domain containing 2	Mus musculus	78-81
23383146-0	2013	Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells.	Gangliosides	48-59	GRDX	Homo sapiens	60-63
23383146-2	2013	The expression of ganglioside GD3, which plays essential roles in normal brain development, decreases in adults but is up regulated in neuroectodermal and epithelial derived cancers.	Gangliosides	18-29	GRDX	Homo sapiens	30-33
23383146-3	2013	R24 antibody, directed against ganglioside GD3, is a validated tumor target which is specifically endocytosed and accumulated in endosomes.	Gangliosides	31-42	GRDX	Homo sapiens	43-46
23383146-9	2013	Thus, the ganglioside GD3 emerge as a novel and attractive class of cell surface molecule for targeted delivery of cytotoxic agents and, therefore, provides a rationale for future therapeutic intervention in cancer.	Gangliosides	10-21	GRDX	Homo sapiens	22-25
22763744-3	2012	In particular, gangliosides GD3 and GD2 are highly expressed in melanomas and small cell lung cancer cells, and their expression cause increased cell growth and invasion.	Gangliosides	15-27	GRDX	Homo sapiens	28-31
23102779-1	2013	OBJECTIVE: To investigate the therapeutic effects of exogenous gangliosides GM3 on human bladder cancer cell lines and the severe combined immunodeficiency mouse model of orthotopic bladder cancer.	Gangliosides	63-75	granulocyte macrophage antigen 3	Mus musculus	76-79
23662477-0	2013	[Metabolic effects of ganglioside GM1 on PC12 cells at oxidative stress depend on modulation of activity of tyrosine kinase of trk receptor].	Gangliosides	22-33	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	127-130
23662477-5	2013	The dependence of protective and metabolic effects of ganglioside GM 1 in PC 12 cells at action on them of H2O2 on modulation of activity of tyrosine kinase of Trk receptors (i. e., on the same signal system) agrees with concept of the essential role of the GM1 antioxidant effect in its increase of cell viability.	Gangliosides	54-65	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	160-163
23139422-1	2012	The human plasma membrane sialidase NEU3 is a key enzyme in the catabolism of membrane gangliosides, is crucial in the regulation of cell surface processes, and has been demonstrated to be significantly up-regulated in renal cell carcinomas (RCCs).	Gangliosides	87-99	neuraminidase 3	Homo sapiens	36-40
23139422-3	2012	NEU3 silencing in RCC cells increased the membrane ganglioside content, in particular the GD1a content, and changed the expression of key regulators of the integrin recycling pathway.	Gangliosides	51-62	neuraminidase 3	Homo sapiens	0-4
23074226-0	2012	Ablation of neuronal ceramide synthase 1 in mice decreases ganglioside levels and expression of myelin-associated glycoprotein in oligodendrocytes.	Gangliosides	59-70	ceramide synthase 1	Mus musculus	21-40
23074226-6	2012	Expression of myelin-associated glycoprotein was also decreased by about 60% in cerebellum and forebrain, suggesting that interaction and stabilization of oligodendrocytic myelin-associated glycoprotein by neuronal gangliosides is due to the C18 acyl membrane anchor of CerS1-derived precursor ceramides.	Gangliosides	215-227	myelin-associated glycoprotein	Mus musculus	14-44
23074226-6	2012	Expression of myelin-associated glycoprotein was also decreased by about 60% in cerebellum and forebrain, suggesting that interaction and stabilization of oligodendrocytic myelin-associated glycoprotein by neuronal gangliosides is due to the C18 acyl membrane anchor of CerS1-derived precursor ceramides.	Gangliosides	215-227	myelin-associated glycoprotein	Mus musculus	172-202
22610315-6	2012	The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation.	Gangliosides	24-35	granulocyte macrophage antigen 3	Mus musculus	36-39
22610315-6	2012	The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation.	Gangliosides	24-35	epidermal growth factor receptor	Mus musculus	97-129
22610315-6	2012	The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation.	Gangliosides	24-35	epidermal growth factor receptor	Mus musculus	131-135
22610315-6	2012	The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation.	Gangliosides	24-35	granulocyte macrophage antigen 3	Mus musculus	213-216
22610315-6	2012	The interaction between ganglioside GM3, and multi (>3) GlcNAc termini of N-linked glycans of epidermal growth factor receptor (EGFR), has been indicated as the molecular mechanism for the inhibitory effect of GM3 on EGFR activation.	Gangliosides	24-35	epidermal growth factor receptor	Mus musculus	220-224
23038675-4	2012	In accord with the decreased amounts of gangliosides in cisplatin-resistant cells, the gene expression and specific activity of GM3 synthase were greatly decreased in cisplatin-resistant cells.	Gangliosides	40-52	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	128-140
22936677-1	2012	Ganglioside GD3 is specifically expressed in human melanomas, and plays a role in the enhancement of malignant phenotypes of melanoma cells.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
22999096-3	2012	We found that glucocerebroside (GCB) inhibited the infectivity of reovirus strain type 1 Lang (T1L), whereas gangliosides GD3 and GM3 and 3"-sialyllactose (3SL) inhibited the infectivity of reovirus strain type 3 Dearing (T3D).	Gangliosides	109-121	GRDX	Homo sapiens	122-125
22982027-2	2012	Here we show that Galgt1, which synthesizes the beta1,4GalNAc linkage of the CT carbohydrate on gangliosides, is required for presynaptic expression of the CT carbohydrate at the NMJ, while Galgt2, which can synthesize the beta1,4GalNAc of the CT carbohydrate on glycoproteins, is required for postsynaptic expression.	Gangliosides	96-108	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	18-24
22982027-2	2012	Here we show that Galgt1, which synthesizes the beta1,4GalNAc linkage of the CT carbohydrate on gangliosides, is required for presynaptic expression of the CT carbohydrate at the NMJ, while Galgt2, which can synthesize the beta1,4GalNAc of the CT carbohydrate on glycoproteins, is required for postsynaptic expression.	Gangliosides	96-108	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	190-196
23027864-9	2012	Characterizing the heavy chain receptor binding domain (HCR), BoNT/C was shown to utilize gangliosides as dual host receptors.	Gangliosides	90-102	coiled-coil alpha-helical rod protein 1	Mus musculus	56-59
23027864-10	2012	Crystallographic and biochemical studies showed that the two ganglioside binding sites, termed GBP2 and Sia-1, were independent and utilized unique mechanisms to bind complex gangliosides.	Gangliosides	61-72	guanylate binding protein 2	Mus musculus	95-99
23027864-10	2012	Crystallographic and biochemical studies showed that the two ganglioside binding sites, termed GBP2 and Sia-1, were independent and utilized unique mechanisms to bind complex gangliosides.	Gangliosides	175-187	guanylate binding protein 2	Mus musculus	95-99
23027864-11	2012	The GBP2 binding site recognized gangliosides that contained a sia5 sialic acid, whereas the Sia-1 binding site recognized gangliosides that contained a sia7 sialic acid and sugars within the backbone of the ganglioside.	Gangliosides	33-45	guanylate binding protein 2	Mus musculus	4-8
23027864-11	2012	The GBP2 binding site recognized gangliosides that contained a sia5 sialic acid, whereas the Sia-1 binding site recognized gangliosides that contained a sia7 sialic acid and sugars within the backbone of the ganglioside.	Gangliosides	33-44	guanylate binding protein 2	Mus musculus	4-8
23027864-12	2012	Utilizing gangliosides that uniquely recognized the GBP2 and Sia-1 binding sites, HCR/C entry into Neuro-2A cells required both functional ganglioside binding sites.	Gangliosides	10-22	guanylate binding protein 2	Mus musculus	52-56
23027864-12	2012	Utilizing gangliosides that uniquely recognized the GBP2 and Sia-1 binding sites, HCR/C entry into Neuro-2A cells required both functional ganglioside binding sites.	Gangliosides	10-22	coiled-coil alpha-helical rod protein 1	Mus musculus	82-85
23027864-12	2012	Utilizing gangliosides that uniquely recognized the GBP2 and Sia-1 binding sites, HCR/C entry into Neuro-2A cells required both functional ganglioside binding sites.	Gangliosides	10-21	guanylate binding protein 2	Mus musculus	52-56
23027864-12	2012	Utilizing gangliosides that uniquely recognized the GBP2 and Sia-1 binding sites, HCR/C entry into Neuro-2A cells required both functional ganglioside binding sites.	Gangliosides	10-21	coiled-coil alpha-helical rod protein 1	Mus musculus	82-85
23027864-13	2012	HCR/C entered cells differently than the HCR of tetanus toxin, which also utilizes dual gangliosides as host receptors.	Gangliosides	88-100	coiled-coil alpha-helical rod protein 1	Mus musculus	0-3
23027864-13	2012	HCR/C entered cells differently than the HCR of tetanus toxin, which also utilizes dual gangliosides as host receptors.	Gangliosides	88-100	coiled-coil alpha-helical rod protein 1	Mus musculus	41-44
22936677-5	2012	These results suggested that EMARS reaction is useful to identify actually interacting molecules with gangliosides such as GD3 on the cell membrane, and many other microdomains than GD3-associating rafts exist.	Gangliosides	102-114	GRDX	Homo sapiens	123-126
22735313-11	2012	We conclude that the St3gal2 and St3gal3 gene products (ST3Gal-II and ST3Gal-III sialyltransferases) are largely responsible for ganglioside terminal alpha2-3 sialylation in the brain, synthesizing the major brain gangliosides GD1a and GT1b.	Gangliosides	129-140	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	56-65
22735313-11	2012	We conclude that the St3gal2 and St3gal3 gene products (ST3Gal-II and ST3Gal-III sialyltransferases) are largely responsible for ganglioside terminal alpha2-3 sialylation in the brain, synthesizing the major brain gangliosides GD1a and GT1b.	Gangliosides	129-140	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Mus musculus	70-80
22735313-5	2012	We report that St3gal2 and St3gal3 are responsible for nearly all the terminal sialylation of brain gangliosides in the mouse.	Gangliosides	100-112	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	15-22
22735313-11	2012	We conclude that the St3gal2 and St3gal3 gene products (ST3Gal-II and ST3Gal-III sialyltransferases) are largely responsible for ganglioside terminal alpha2-3 sialylation in the brain, synthesizing the major brain gangliosides GD1a and GT1b.	Gangliosides	129-140	cholinergic receptor, nicotinic, alpha polypeptide 3	Mus musculus	150-158
22735313-5	2012	We report that St3gal2 and St3gal3 are responsible for nearly all the terminal sialylation of brain gangliosides in the mouse.	Gangliosides	100-112	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Mus musculus	27-34
22632091-2	2012	In this study, we showed that gangliosides GD3 and GD2 are highly expressed in the majority of human osteosarcoma cell lines derived from oral cavity regions.	Gangliosides	30-42	GRDX	Homo sapiens	43-46
22735313-6	2012	When brain ganglioside expression was analyzed in adult St3gal1-, St3gal2-, St3gal3- and St3gal4-null mice, only St3gal2-null mice differed significantly from wild type, expressing half the normal amount of GD1a and GT1b.	Gangliosides	11-22	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Mus musculus	76-83
22735313-6	2012	When brain ganglioside expression was analyzed in adult St3gal1-, St3gal2-, St3gal3- and St3gal4-null mice, only St3gal2-null mice differed significantly from wild type, expressing half the normal amount of GD1a and GT1b.	Gangliosides	11-22	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	Mus musculus	89-96
22735313-6	2012	When brain ganglioside expression was analyzed in adult St3gal1-, St3gal2-, St3gal3- and St3gal4-null mice, only St3gal2-null mice differed significantly from wild type, expressing half the normal amount of GD1a and GT1b.	Gangliosides	11-22	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	113-120
22735313-7	2012	St3gal1/2-double-null mice were no different than St3gal2-single-null mice; however, St3gal2/3-double-null mice were >95% depleted in gangliosides GD1a and GT1b.	Gangliosides	137-149	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	85-94
22735313-8	2012	Total ganglioside expression (lipid-bound sialic acid) in the brains of St3gal2/3-double-null mice was equivalent to that in wild-type mice, whereas total protein sialylation was reduced by half.	Gangliosides	6-17	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	72-81
22735313-11	2012	We conclude that the St3gal2 and St3gal3 gene products (ST3Gal-II and ST3Gal-III sialyltransferases) are largely responsible for ganglioside terminal alpha2-3 sialylation in the brain, synthesizing the major brain gangliosides GD1a and GT1b.	Gangliosides	129-140	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	21-28
22735313-11	2012	We conclude that the St3gal2 and St3gal3 gene products (ST3Gal-II and ST3Gal-III sialyltransferases) are largely responsible for ganglioside terminal alpha2-3 sialylation in the brain, synthesizing the major brain gangliosides GD1a and GT1b.	Gangliosides	129-140	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Mus musculus	33-40
22956583-10	2012	Thus, tumor-shed gangliosides suppress lytic activity of CD8(+) T cells by a novel mechanism, that is, inhibition of trafficking of lytic granules in response to TCR engagement, as well as by interfering with the process of granule exocytosis in CD8(+) T cells.	Gangliosides	17-29	T cell receptor alpha variable 6-3	Mus musculus	162-165
22778098-5	2012	Next, we found that ganglioside-like LOS facilitated endocytosis of bacteria into Caco-2 cells, as visualized by quantitative microscopy using the early and late endosomal markers early endosome-associated protein 1 (EEA1), Rab5, and lysosome-associated membrane protein 1 (LAMP-1).	Gangliosides	20-31	early endosome antigen 1	Homo sapiens	217-221
22778098-5	2012	Next, we found that ganglioside-like LOS facilitated endocytosis of bacteria into Caco-2 cells, as visualized by quantitative microscopy using the early and late endosomal markers early endosome-associated protein 1 (EEA1), Rab5, and lysosome-associated membrane protein 1 (LAMP-1).	Gangliosides	20-31	RAB5A, member RAS oncogene family	Homo sapiens	224-228
22778098-5	2012	Next, we found that ganglioside-like LOS facilitated endocytosis of bacteria into Caco-2 cells, as visualized by quantitative microscopy using the early and late endosomal markers early endosome-associated protein 1 (EEA1), Rab5, and lysosome-associated membrane protein 1 (LAMP-1).	Gangliosides	20-31	lysosomal associated membrane protein 1	Homo sapiens	234-272
22778098-5	2012	Next, we found that ganglioside-like LOS facilitated endocytosis of bacteria into Caco-2 cells, as visualized by quantitative microscopy using the early and late endosomal markers early endosome-associated protein 1 (EEA1), Rab5, and lysosome-associated membrane protein 1 (LAMP-1).	Gangliosides	20-31	lysosomal associated membrane protein 1	Homo sapiens	274-280
22552967-9	2012	We postulate that sialidase NEU3, decreasing plasma membrane ganglioside GM3 content, affects the EGF receptor and the downstream signaling pathways, promoting proliferation and delaying differentiation.	Gangliosides	61-72	neuraminidase 3	Mus musculus	28-32
22552967-9	2012	We postulate that sialidase NEU3, decreasing plasma membrane ganglioside GM3 content, affects the EGF receptor and the downstream signaling pathways, promoting proliferation and delaying differentiation.	Gangliosides	61-72	granulocyte macrophage antigen 3	Mus musculus	73-76
22885356-3	2012	ST8Sia I (EC 2.4.99.8, SAT-II, SIAT 8a) is the key enzyme controlling the biosynthesis of b- and c-series gangliosides.	Gangliosides	106-118	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	0-8
22947931-7	2012	Whereas pore formation by freshly dissolved Abeta(1-40) is weakly observed in the absence of gangliosides, fiber-dependent membrane fragmentation can only be observed in their presence.	Gangliosides	93-105	amyloid beta precursor protein	Homo sapiens	44-49
22638855-0	2012	Neuroplastin expression in the hippocampus of mice lacking complex gangliosides.	Gangliosides	67-79	neuroplastin	Mus musculus	0-12
22638855-1	2012	We report changes in neuroplastin gene and protein expression in the hippocampus of B4galnt1 null mice, which lacks complex ganglioside structures, compared with that of wild-type mice.	Gangliosides	124-135	neuroplastin	Mus musculus	21-33
22638855-1	2012	We report changes in neuroplastin gene and protein expression in the hippocampus of B4galnt1 null mice, which lacks complex ganglioside structures, compared with that of wild-type mice.	Gangliosides	124-135	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	84-92
22638855-6	2012	Results of this study support the hypothesis that alterations of brain ganglioside expression influence the expression of neuroplastin.	Gangliosides	71-82	neuroplastin	Mus musculus	122-134
22867887-2	2012	A deficiency in Naglu activity leads to lysosomal accumulation of HS as a primary storage substrate, and the gangliosides GM2 and GM3 as secondary accumulation products.	Gangliosides	109-121	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	Mus musculus	16-21
22867887-2	2012	A deficiency in Naglu activity leads to lysosomal accumulation of HS as a primary storage substrate, and the gangliosides GM2 and GM3 as secondary accumulation products.	Gangliosides	109-121	cytochrome b5 domain containing 2	Mus musculus	122-125
22867887-4	2012	The latter is the enzyme required for synthesis of GM2 and other complex gangliosides.	Gangliosides	73-85	cytochrome b5 domain containing 2	Mus musculus	51-54
22885356-3	2012	ST8Sia I (EC 2.4.99.8, SAT-II, SIAT 8a) is the key enzyme controlling the biosynthesis of b- and c-series gangliosides.	Gangliosides	106-118	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	31-38
22885356-5	2012	ST8Sia I together with b- and c-series gangliosides are also over-expressed in neuroectoderm-derived malignant tumors such as melanoma, glioblastoma, neuroblastoma and in estrogen receptor (ER) negative breast cancer, where they play a role in cell proliferation, migration, adhesion and angiogenesis.	Gangliosides	39-51	estrogen receptor 1	Homo sapiens	171-188
22885356-5	2012	ST8Sia I together with b- and c-series gangliosides are also over-expressed in neuroectoderm-derived malignant tumors such as melanoma, glioblastoma, neuroblastoma and in estrogen receptor (ER) negative breast cancer, where they play a role in cell proliferation, migration, adhesion and angiogenesis.	Gangliosides	39-51	estrogen receptor 1	Homo sapiens	190-192
22885356-9	2012	In parallel, the expression of ST8Sia I in MCF-7 GD3S+ clones resulted in a dramatic change in ganglioside composition, with the expression of b- and c-series gangliosides as well as unusual tetra- and pentasialylated lactosylceramide derivatives G(Q3) (II(3)Neu5Ac(4)-Gg(2)Cer) and G(P3) (II(3)Neu5Ac(5)-Gg(2)Cer).	Gangliosides	95-106	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	31-39
22885356-9	2012	In parallel, the expression of ST8Sia I in MCF-7 GD3S+ clones resulted in a dramatic change in ganglioside composition, with the expression of b- and c-series gangliosides as well as unusual tetra- and pentasialylated lactosylceramide derivatives G(Q3) (II(3)Neu5Ac(4)-Gg(2)Cer) and G(P3) (II(3)Neu5Ac(5)-Gg(2)Cer).	Gangliosides	95-106	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	49-53
22885356-9	2012	In parallel, the expression of ST8Sia I in MCF-7 GD3S+ clones resulted in a dramatic change in ganglioside composition, with the expression of b- and c-series gangliosides as well as unusual tetra- and pentasialylated lactosylceramide derivatives G(Q3) (II(3)Neu5Ac(4)-Gg(2)Cer) and G(P3) (II(3)Neu5Ac(5)-Gg(2)Cer).	Gangliosides	159-171	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	31-39
22649190-3	2012	In this study, we identify ganglioside GD3, which was isolated from the polar lipid fraction of ovarian cancer-associated ascites, as an inhibitory factor that prevents innate immune activation of natural killer T (NKT) cells.	Gangliosides	27-38	GRDX	Homo sapiens	39-42
22454523-6	2012	We also found that gangliosides increase binding of BoNT/D-C to SytI/II and enhance the ability of the SytII luminal fragment to block BoNT/D-C entry into neurons.	Gangliosides	19-31	synaptotagmin 1	Homo sapiens	64-68
22824320-0	2012	Modulation of the neurotensin solution structure in the presence of ganglioside GM1 bicelle.	Gangliosides	68-79	neurotensin	Homo sapiens	18-29
22824320-3	2012	Here we investigate the change of neurotensin solution structure induced by isotropic CHAPS-PC bicelles with and without ganglioside GM1 using solution state NMR spectroscopy.	Gangliosides	121-132	neurotensin	Homo sapiens	34-45
22577166-3	2012	Both of these gangliosides are enriched in the synapse-forming area of the brain and induce Ca(2+) release from intracellular stores, activation of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) and activation of cdc42 to promote reorganization of cytoskeletal actin and dendritic differentiation.	Gangliosides	14-26	Rho family GTPase CDC42	Saccharomyces cerevisiae S288C	221-226
22454523-6	2012	We also found that gangliosides increase binding of BoNT/D-C to SytI/II and enhance the ability of the SytII luminal fragment to block BoNT/D-C entry into neurons.	Gangliosides	19-31	synaptotagmin 2	Homo sapiens	103-108
21780101-6	2012	The interaction between ezrin and Pgp occurs in the plasma membrane of MDR cells, where they also co-localize with the ganglioside G(M1)  located in lipid rafts.	Gangliosides	119-130	ezrin	Homo sapiens	24-29
21780101-6	2012	The interaction between ezrin and Pgp occurs in the plasma membrane of MDR cells, where they also co-localize with the ganglioside G(M1)  located in lipid rafts.	Gangliosides	119-130	ATP binding cassette subfamily B member 1	Homo sapiens	34-37
22403397-9	2012	Prior siRNA-mediated knockdown of NEU1 and NEU3 each decreased EC sialidase activity for 4-MU-NANA by >65 and >17%, respectively, and for the ganglioside mixture by 0 and 40%, respectively.	Gangliosides	148-159	neuraminidase 1	Homo sapiens	34-38
22367451-1	2012	Sandhoff Disease (SD) involves the CNS accumulation of ganglioside GM2 and asialo-GM2 (GA2) due to inherited defects in the beta-subunit gene of beta-hexosaminidase A and B (Hexb gene).	Gangliosides	55-66	cytochrome b5 domain containing 2	Mus musculus	67-85
22367451-1	2012	Sandhoff Disease (SD) involves the CNS accumulation of ganglioside GM2 and asialo-GM2 (GA2) due to inherited defects in the beta-subunit gene of beta-hexosaminidase A and B (Hexb gene).	Gangliosides	55-66	hexosaminidase B	Mus musculus	174-178
22483798-5	2012	This cell cycle-arrest was possibly also linked to the reduced cellular ability to capture and internalize receptors as illustrated by the lipid marker ganglioside GM1.	Gangliosides	152-163	coenzyme Q10A	Mus musculus	164-167
22301273-0	2012	The ganglioside G(D2) induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the G(D3) synthase.	Gangliosides	4-15	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	61-66
22301273-0	2012	The ganglioside G(D2) induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the G(D3) synthase.	Gangliosides	4-15	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	116-130
22301273-1	2012	We have recently established and characterized cellular clones deriving from MDA-MB-231 breast cancer cells that express the human G(D3) synthase (GD3S), the enzyme that controls the biosynthesis of b- and c-series gangliosides.	Gangliosides	215-227	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	131-145
22301273-1	2012	We have recently established and characterized cellular clones deriving from MDA-MB-231 breast cancer cells that express the human G(D3) synthase (GD3S), the enzyme that controls the biosynthesis of b- and c-series gangliosides.	Gangliosides	215-227	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	147-151
22301273-4	2012	Here, we show by mass spectrometry analysis of total glycosphingolipids that G(D3) and G(D2) are the main gangliosides expressed by the GD3S positive clones.	Gangliosides	106-118	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	136-140
22488330-0	2012	Ganglioside biosynthesis in developing brains and apoptotic cancer cells: X. regulation of glyco-genes involved in GD3 and Sialyl-Lex/a syntheses.	Gangliosides	0-11	GRDX	Homo sapiens	115-118
22795094-0	2012	Altered ganglioside GD3 in HeLa cells might influence the cytotoxic abilities of NK cells.	Gangliosides	8-19	GRDX	Homo sapiens	20-23
22795094-5	2012	Exogenous ganglioside GD3 decreased the cytotoxic ability of the NK cells, which could be restored by the addition of the anti-GD3 antibody.	Gangliosides	10-21	GRDX	Homo sapiens	22-25
22795094-5	2012	Exogenous ganglioside GD3 decreased the cytotoxic ability of the NK cells, which could be restored by the addition of the anti-GD3 antibody.	Gangliosides	10-21	GRDX	Homo sapiens	127-130
22795094-8	2012	CONCLUSIONS: This study suggests that interactions between ganglioside GD3 and sialidases in HeLa cells influence the cytotoxic ability of NK cells.	Gangliosides	59-70	GRDX	Homo sapiens	71-74
22403397-9	2012	Prior siRNA-mediated knockdown of NEU1 and NEU3 each decreased EC sialidase activity for 4-MU-NANA by >65 and >17%, respectively, and for the ganglioside mixture by 0 and 40%, respectively.	Gangliosides	148-159	neuraminidase 3	Homo sapiens	43-47
22289946-0	2012	Intravenous immunoglobulin treatment on anti-GM1 antibodies associated neuropathies inhibits cholera toxin and galectin-1 binding to ganglioside GM1.	Gangliosides	133-144	galectin 1	Homo sapiens	111-121
21554197-0	2012	Ganglioside GD3 as a raft component in cell death regulation.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
22500817-6	2012	Here we demonstrate this aspect by using cholera toxin subunit B (CTB)-ganglioside GM1 (GM1) complexes with different configurations.	Gangliosides	71-82	phosphate cytidylyltransferase 1B, choline	Homo sapiens	66-69
22316564-1	2012	A novel ganglioside-induced differentiation-associated protein 1 gene (BmGDAP1) was first cloned and sequenced from silkworm, Bombyx mori using rapid amplification of cDNA ends (RACE).	Gangliosides	8-19	ganglioside-induced differentiation-associated-protein	Bombyx mori	71-78
22457506-5	2012	One membrane domain, including the stereocilia basal tapers and ~1 mum of the shaft, the location of the ankle links, is enriched in the lipid phosphatase PTPRQ (protein tyrosine phosphatase Q) and polysialylated gangliosides.	Gangliosides	213-225	protein tyrosine phosphatase, receptor type Q	Gallus gallus	155-160
22120109-3	2012	Recent studies have suggested that in addition to gangliosides, other membrane lipids such as phosphoinositides may be involved in the interactions with the receptor binding domain (HCR) of BoNTs for better membrane penetration.	Gangliosides	50-62	C-C motif chemokine receptor like 2	Homo sapiens	182-185
22271523-5	2012	In contrast, genetic mutations in B4galnt1 and B4galnt2 (GalNAc transferase, responsible for the synthesis of many gangliosides) induced no discernable alteration.	Gangliosides	115-127	beta-1,4-N-acetyl-galactosaminyltransferase 2	Homo sapiens	47-55
22179062-1	2012	The total synthesis of ganglioside 2, an analogue of the ganglioside Hp-s1 (1) which displays neuritogenic activity toward the rat pheochromocytoma cell line PC-12 cell in the presence of nerve growth factor (NGF) with an effect (34.0%) greater than that of the mammalian ganglioside GM 1 (25.4%), was accomplished by applying a chemoselective-activation glycosylation strategy.	Gangliosides	23-34	nerve growth factor	Rattus norvegicus	188-207
22331905-0	2012	Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-15
22331905-0	2012	Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice.	Gangliosides	0-11	huntingtin	Mus musculus	50-60
22179062-1	2012	The total synthesis of ganglioside 2, an analogue of the ganglioside Hp-s1 (1) which displays neuritogenic activity toward the rat pheochromocytoma cell line PC-12 cell in the presence of nerve growth factor (NGF) with an effect (34.0%) greater than that of the mammalian ganglioside GM 1 (25.4%), was accomplished by applying a chemoselective-activation glycosylation strategy.	Gangliosides	23-34	nerve growth factor	Rattus norvegicus	209-212
22200571-1	2012	Previously, we demonstrated that an inhibitor of ganglioside biosynthesis, d-PDMP, could restore impaired insulin signaling in tumor necrosis factor alpha (TNFalpha)-treated adipocytes by blocking the increase of GM3 ganglioside.	Gangliosides	49-60	tumor necrosis factor	Homo sapiens	127-154
22119928-1	2012	Methylotrophic yeast (Pichia pastoris) secreted cholera toxin B subunit (CTB) predominantly as a biologically active pentamer (PpCTB) with identical ganglioside binding affinity profiles to that of choleragenoid.	Gangliosides	149-160	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	73-76
22308377-0	2012	CD4 and CD8 T cells require different membrane gangliosides for activation.	Gangliosides	47-59	CD4 antigen	Mus musculus	0-3
22308377-3	2012	While investigating T-cell activation in ganglioside-deficient mice, we observed that CD4(+) and CD8(+) T cells required different ganglioside subsets for activation.	Gangliosides	41-52	CD4 antigen	Mus musculus	86-89
22308377-3	2012	While investigating T-cell activation in ganglioside-deficient mice, we observed that CD4(+) and CD8(+) T cells required different ganglioside subsets for activation.	Gangliosides	131-142	CD4 antigen	Mus musculus	86-89
22308377-8	2012	Distinct expression patterns of ganglioside species in CD4(+) T and CD8(+) T cells, perhaps in uniquely functional lipid rafts, define immune functions in each T-cell subset.	Gangliosides	32-43	CD4 antigen	Mus musculus	55-58
22058197-7	2012	Further results ascribed the resistance of these latter cases to a defective recruitment of Csk-binding protein, resulting in a lack of sphingomyelin and ganglioside M1 at the outer leaflet of the plasma membrane of their malignant B cells.	Gangliosides	154-165	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	92-111
22200571-1	2012	Previously, we demonstrated that an inhibitor of ganglioside biosynthesis, d-PDMP, could restore impaired insulin signaling in tumor necrosis factor alpha (TNFalpha)-treated adipocytes by blocking the increase of GM3 ganglioside.	Gangliosides	49-60	tumor necrosis factor	Homo sapiens	156-164
22200571-6	2012	Thus, we could obtain direct evidence that insulin resistance is a membrane microdomain disorder caused by aberrant expression of ganglioside.	Gangliosides	130-141	insulin	Homo sapiens	43-50
21681193-2	2012	To understand the underlying mechanisms and facilitate the development of novel treatments for androgen-independent prostate cancer, we have investigated plasma membrane-associated sialidase (NEU3), the key enzyme for ganglioside hydrolysis participating in transmembrane signaling.	Gangliosides	218-229	neuraminidase 3	Homo sapiens	161-196
22243965-5	2012	Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1 encoding a highly conserved acetylCoA transporter (AT-1) required for acetylation of multiple gangliosides and glycoproteins.	Gangliosides	231-243	solute carrier family 33 member 1	Homo sapiens	129-136
22243965-5	2012	Deep sequencing and conventional sequencing disclosed homozygous or compound heterozygous mutations for all affected subjects in SLC33A1 encoding a highly conserved acetylCoA transporter (AT-1) required for acetylation of multiple gangliosides and glycoproteins.	Gangliosides	231-243	solute carrier family 33 member 1	Homo sapiens	188-192
23124246-4	2012	These results indicate that de novo synthesis of gangliosides in the brain is involved in synaptic plasticity of LTP in mouse hippocampal CA1 neurons and plays important roles in learning and memory.	Gangliosides	49-61	carbonic anhydrase 1	Mus musculus	138-141
22202073-6	2012	Inhibitory effects of gangliosides ultimately converge to T cell apoptosis in receptor-dependent and -independent manners via IL-2 deprivation, ROS production, cytochrome c release, NFkappaB inhibition and caspase activation.	Gangliosides	22-34	interleukin 2	Homo sapiens	126-130
22202073-6	2012	Inhibitory effects of gangliosides ultimately converge to T cell apoptosis in receptor-dependent and -independent manners via IL-2 deprivation, ROS production, cytochrome c release, NFkappaB inhibition and caspase activation.	Gangliosides	22-34	cytochrome c, somatic	Homo sapiens	160-172
22202073-6	2012	Inhibitory effects of gangliosides ultimately converge to T cell apoptosis in receptor-dependent and -independent manners via IL-2 deprivation, ROS production, cytochrome c release, NFkappaB inhibition and caspase activation.	Gangliosides	22-34	nuclear factor kappa B subunit 1	Homo sapiens	182-190
22864347-5	2012	Nevertheless, we have succeeded in detecting endogenous mouse GM3 synthase (GM3S), the primary glycosyltransferase responsible for the biosynthesis of ganglio-series gangliosides.	Gangliosides	166-178	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	62-74
23271952-0	2012	Siglec-1 is a novel dendritic cell receptor that mediates HIV-1 trans-infection through recognition of viral membrane gangliosides.	Gangliosides	118-130	sialic acid binding Ig like lectin 1	Homo sapiens	0-8
22815940-3	2012	We previously reported that the membrane-associated mammalian sialidase NEU3, which preferentially acts on gangliosides, is involved in cell differentiation, motility, and tumorigenesis.	Gangliosides	107-119	neuraminidase 3	Mus musculus	72-76
22470521-5	2012	Since GD3S is the key enzyme converting a- to b-series gangliosides, it therefore plays a major role in controlling the levels of major brain gangliosides.	Gangliosides	55-67	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	6-10
22470521-5	2012	Since GD3S is the key enzyme converting a- to b-series gangliosides, it therefore plays a major role in controlling the levels of major brain gangliosides.	Gangliosides	142-154	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	6-10
22470521-7	2012	The first mechanism directly targets the enzymatic activity of GD3S: Upon binding of Abeta to the ganglioside GM3, the immediate substrate of the GD3S, enzymatic turnover of GM3 by GD3S was strongly reduced.	Gangliosides	98-109	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	63-67
22470521-7	2012	The first mechanism directly targets the enzymatic activity of GD3S: Upon binding of Abeta to the ganglioside GM3, the immediate substrate of the GD3S, enzymatic turnover of GM3 by GD3S was strongly reduced.	Gangliosides	98-109	amyloid beta precursor protein	Homo sapiens	85-90
22470521-7	2012	The first mechanism directly targets the enzymatic activity of GD3S: Upon binding of Abeta to the ganglioside GM3, the immediate substrate of the GD3S, enzymatic turnover of GM3 by GD3S was strongly reduced.	Gangliosides	98-109	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	146-150
22470521-7	2012	The first mechanism directly targets the enzymatic activity of GD3S: Upon binding of Abeta to the ganglioside GM3, the immediate substrate of the GD3S, enzymatic turnover of GM3 by GD3S was strongly reduced.	Gangliosides	98-109	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	146-150
22470521-11	2012	Equally, knock-out of the presenilin genes, presenilin 1 and presenilin 2, essential for Abeta and AICD production, or of APP itself, increased GD3S activity and expression and consequently resulted in a major shift of a- to b-series gangliosides.	Gangliosides	234-246	presenilin 1	Homo sapiens	44-56
22470521-11	2012	Equally, knock-out of the presenilin genes, presenilin 1 and presenilin 2, essential for Abeta and AICD production, or of APP itself, increased GD3S activity and expression and consequently resulted in a major shift of a- to b-series gangliosides.	Gangliosides	234-246	presenilin 2	Homo sapiens	61-73
22465916-3	2012	We previously revealed, by performing live-cell FRAP and SPT studies, a mechanism of insulin resistance in which dissociation of the insulin receptor (IR)-caveolin-1 (Cav1) complex was caused by an interaction between the IRbeta subunit and the ganglioside GM3 cluster, a glycolipid-enriched membrane microdomain.	Gangliosides	245-256	caveolin-1	Cricetulus griseus	167-171
22545022-3	2012	Here, we show that gangliosides in the HIV-1 membrane are the key molecules for mDC uptake.	Gangliosides	19-31	chemokine (C-C motif) ligand 22	Mus musculus	80-83
22545022-6	2012	Furthermore, the sialyllactose molecule present in specific gangliosides was identified as the determinant moiety for mDC HIV-1 uptake.	Gangliosides	60-72	chemokine (C-C motif) ligand 22	Mus musculus	118-121
22768242-0	2012	Ganglioside GM3 has an essential role in the pathogenesis and progression of rheumatoid arthritis.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
22768242-3	2012	Levels of the ganglioside GM3, one of the most primitive glycosphingolipids containing a sialic acid in the structure, are remarkably decreased in the synovium of patients with RA.	Gangliosides	14-25	granulocyte macrophage antigen 3	Mus musculus	26-29
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	Gangliosides	4-15	nerve growth factor	Homo sapiens	54-57
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	Gangliosides	4-15	neurotrophic receptor tyrosine kinase 1	Homo sapiens	59-63
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	Gangliosides	4-15	PC4 and SFRS1 interacting protein 1	Homo sapiens	111-114
22496904-6	2012	The ganglioside, GM1, caused increased association of NGF, TrkA, and microtubules with DRMs, but a decrease in p75(NTR).	Gangliosides	4-15	neurotensin receptor 1	Homo sapiens	115-118
22470521-13	2012	GM3 decreased, whereas the ganglioside GD3, the GD3S product, increased Abeta production, resulting in a regulatory feedback cycle, directly linking ganglioside metabolism with APP processing and Abeta generation.	Gangliosides	27-38	GRDX	Homo sapiens	39-42
22470521-13	2012	GM3 decreased, whereas the ganglioside GD3, the GD3S product, increased Abeta production, resulting in a regulatory feedback cycle, directly linking ganglioside metabolism with APP processing and Abeta generation.	Gangliosides	27-38	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	48-52
22470521-13	2012	GM3 decreased, whereas the ganglioside GD3, the GD3S product, increased Abeta production, resulting in a regulatory feedback cycle, directly linking ganglioside metabolism with APP processing and Abeta generation.	Gangliosides	27-38	amyloid beta precursor protein	Homo sapiens	72-77
22470521-13	2012	GM3 decreased, whereas the ganglioside GD3, the GD3S product, increased Abeta production, resulting in a regulatory feedback cycle, directly linking ganglioside metabolism with APP processing and Abeta generation.	Gangliosides	27-38	amyloid beta precursor protein	Homo sapiens	196-201
23236285-5	2012	We have identified the oligosaccharide portion of ganglioside GM2 (the GM2 glycan) as a receptor for the attachment protein sigma1 of reovirus strain type 1 Lang (T1L) using glycan array screening.	Gangliosides	50-61	cytochrome b5 domain containing 2	Mus musculus	62-65
23236285-5	2012	We have identified the oligosaccharide portion of ganglioside GM2 (the GM2 glycan) as a receptor for the attachment protein sigma1 of reovirus strain type 1 Lang (T1L) using glycan array screening.	Gangliosides	50-61	cytochrome b5 domain containing 2	Mus musculus	71-74
22864347-5	2012	Nevertheless, we have succeeded in detecting endogenous mouse GM3 synthase (GM3S), the primary glycosyltransferase responsible for the biosynthesis of ganglio-series gangliosides.	Gangliosides	166-178	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	76-80
22033101-0	2011	Relationship between ganglioside expression and anti-cancer effects of the monoclonal antibody against epithelial cell adhesion molecule in colon cancer.	Gangliosides	21-32	epithelial cell adhesion molecule	Homo sapiens	103-136
22033101-4	2011	The relationship between ganglioside expression and the anti- cancer effects of anti-EpCAM mAb and RAW264.7 was investigated by high-performance thin-layer chromatography.	Gangliosides	25-36	epithelial cell adhesion molecule	Homo sapiens	85-90
21895867-1	2011	NEU3 is a membrane sialidase specific for gangliosides.	Gangliosides	42-54	neuraminidase 3	Homo sapiens	0-4
21895867-1	2011	NEU3 is a membrane sialidase specific for gangliosides.	Gangliosides	42-54	neuraminidase 3	Homo sapiens	10-28
21895875-2	2011	We examined the antimetastatic effects of the humanized anti-ganglioside GM2 (GM2) antibodies, BIW-8962 and KM8927, compared with the chimeric antibody KM966, in a SCID mouse model of multiple organ metastases induced by GM2-expressing SCLC cells.	Gangliosides	61-72	cytochrome b5 domain containing 2	Mus musculus	73-76
21930390-3	2011	Here we describe the effect of gangliosides on the specific granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced proliferation.	Gangliosides	31-43	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	60-108
21930390-3	2011	Here we describe the effect of gangliosides on the specific granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced proliferation.	Gangliosides	31-43	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	110-116
22123862-6	2011	Identification and isolation of the ST3GAL5 and SLC35A2 mutant clonal cells uncover a previously unappreciated differential contribution of gangliosides to intoxication by CTx.	Gangliosides	140-152	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	36-43
21624052-4	2011	In recent years, the ganglioside-binding sites of all seven BoNT serotypes have been allocated to the H(CC)  domain.	Gangliosides	21-32	HCC	Homo sapiens	102-107
22123862-6	2011	Identification and isolation of the ST3GAL5 and SLC35A2 mutant clonal cells uncover a previously unappreciated differential contribution of gangliosides to intoxication by CTx.	Gangliosides	140-152	solute carrier family 35 member A2	Homo sapiens	48-55
21820419-5	2011	We have identified the ganglioside GM1 as a high affinity interactor, capable of modulating p63 transcriptional ability exclusively on epidermal target genes.	Gangliosides	23-34	tumor protein p63	Homo sapiens	92-95
21949119-2	2011	Clones with high GM3 synthase expression had elevated ganglioside levels, reduced in vitro cell motility, and enhanced expression of the membrane adaptor protein caveolin-1 with respect to wild-type cells.	Gangliosides	54-65	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	17-29
21949119-3	2011	In high GM3 synthase-expressing clones, both depletion of gangliosides by treatment with the glucosylceramide synthase inhibitor D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and silencing of caveolin-1 by siRNA were able to strongly increase in vitro cell motility.	Gangliosides	58-70	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	8-20
21949119-3	2011	In high GM3 synthase-expressing clones, both depletion of gangliosides by treatment with the glucosylceramide synthase inhibitor D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and silencing of caveolin-1 by siRNA were able to strongly increase in vitro cell motility.	Gangliosides	58-70	UDP-glucose ceramide glucosyltransferase	Homo sapiens	93-118
21949119-3	2011	In high GM3 synthase-expressing clones, both depletion of gangliosides by treatment with the glucosylceramide synthase inhibitor D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol and silencing of caveolin-1 by siRNA were able to strongly increase in vitro cell motility.	Gangliosides	58-70	caveolin 1	Homo sapiens	203-213
21949119-4	2011	The motility of wild-type, low GM3 synthase-expressing cells was reduced in the presence of a Src inhibitor, and treatment of these cells with exogenous gangliosides, able to reduce their in vitro motility, inactivated c-Src kinase.	Gangliosides	153-165	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	31-43
21949119-4	2011	The motility of wild-type, low GM3 synthase-expressing cells was reduced in the presence of a Src inhibitor, and treatment of these cells with exogenous gangliosides, able to reduce their in vitro motility, inactivated c-Src kinase.	Gangliosides	153-165	Src oncogene at 64B	Drosophila melanogaster	94-97
21949119-4	2011	The motility of wild-type, low GM3 synthase-expressing cells was reduced in the presence of a Src inhibitor, and treatment of these cells with exogenous gangliosides, able to reduce their in vitro motility, inactivated c-Src kinase.	Gangliosides	153-165	C-terminal Src kinase	Drosophila melanogaster	219-231
21949119-5	2011	Conversely, ganglioside depletion by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol treatment or caveolin-1 silencing in high GM3 synthase-expressing cells led to c-Src kinase activation.	Gangliosides	12-23	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	136-148
21949119-5	2011	Conversely, ganglioside depletion by D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol treatment or caveolin-1 silencing in high GM3 synthase-expressing cells led to c-Src kinase activation.	Gangliosides	12-23	C-terminal Src kinase	Drosophila melanogaster	173-185
21949119-7	2011	These data suggest a role for gangliosides in regulating tumor cell motility by affecting the function of a signaling complex organized by caveolin-1, responsible for Src inactivation downstream to integrin receptors, and imply that GM3 synthase is a key target for the regulation of cell motility in human ovarian carcinoma.	Gangliosides	30-42	caveolin 1	Homo sapiens	139-149
21949119-7	2011	These data suggest a role for gangliosides in regulating tumor cell motility by affecting the function of a signaling complex organized by caveolin-1, responsible for Src inactivation downstream to integrin receptors, and imply that GM3 synthase is a key target for the regulation of cell motility in human ovarian carcinoma.	Gangliosides	30-42	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	167-170
21949119-7	2011	These data suggest a role for gangliosides in regulating tumor cell motility by affecting the function of a signaling complex organized by caveolin-1, responsible for Src inactivation downstream to integrin receptors, and imply that GM3 synthase is a key target for the regulation of cell motility in human ovarian carcinoma.	Gangliosides	30-42	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	233-245
21913655-0	2011	Mammalian sialyltransferase ST3Gal-II: its exchange sialylation catalytic properties allow labeling of sialyl residues in mucin-type sialylated glycoproteins and specific gangliosides.	Gangliosides	171-183	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	28-37
21913655-4	2011	This study shows by using [9-(3)H]- or [(14)C]sialyl mucin core 2 compounds that ST3Gal-II exchanges sialyl residues between CMP-NeuAc and the NeuAcalpha2,3Galbeta1,3GalNAc unit and also radiolabels sialyl residues in gangliosides GD1a and GT1b, but not GM1.	Gangliosides	218-230	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	81-90
21302303-6	2011	Moreover, a significant increase was observed in the expression of CD95 receptor, GD3 ganglioside and, caspase-2 and -8 active forms in both cell lines followed by caspase-3 activation and mitochondrial membrane depolarization.	Gangliosides	86-97	GRDX	Homo sapiens	82-85
21288691-7	2011	RESULTS: Total lipid-bound sialic acid of human milk gangliosides after preterm delivery showed a peak concentration at 2 to 3 d postpartum and then remained at a high concentration until approximately 10 d. GD3 was the major ganglioside in the colostrum until approximately 7 to 10 d postpartum.	Gangliosides	53-65	GRDX	Homo sapiens	208-211
21165949-0	2011	Expression of gangliosides, GD1a, and sialyl paragloboside is regulated by NF-kappaB-dependent transcriptional control of alpha2,3-sialyltransferase I, II, and VI in human castration-resistant prostate cancer cells.	Gangliosides	14-26	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	122-162
21165949-3	2011	In our previous report, ganglioside GD1a and sialyl paragloboside (SPG), a neolacto-series ganglioside, were much more abundant in PC3 and DU145 cells, castration-resistant prostate cancer cells, as compared with hormone-sensitive prostate cancer cells and normal prostate epithelium.	Gangliosides	24-35	keratin 6A	Homo sapiens	131-134
21693704-6	2011	The lipid raft marker, ganglioside GM1, co-localizes with CD44 on the plasma membrane, and C. neoformans cells can adhere to the host cell in areas where GM1 is enriched.	Gangliosides	23-34	CD44 molecule (Indian blood group)	Homo sapiens	58-62
21733970-6	2011	These results suggest that the overexpression of beta1,4 GalNAc-T resulted in altered synaptic plasticity of LTP and DP in hippocampal CA1 neurons and learning in the 4PTT, and this is attributable to the shift from b-pathway gangliosides to a-pathway gangliosides.	Gangliosides	226-238	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	49-65
21941093-2	2011	Firstly, the fully soluble AHc-C protein successfully expressed in Escherichia coli by co-expression with thioredoxin (Trx) was shown to bind with ganglioside as the AHc, indicating that the recombinant AHc-C protein retains a functionally active conformation.	Gangliosides	147-158	nuclear receptor subfamily 0, group B, member 1	Mus musculus	27-30
21941093-3	2011	Furthermore, a solid-phase assay showed that the anti-AHc-C sera effectively inhibited the binding of AHc or AHc-C to the ganglioside GT1b, the first step in BoNT/A intoxication of neurons, as good as the anti-AHc sera.	Gangliosides	122-133	nuclear receptor subfamily 0, group B, member 1	Mus musculus	54-57
21941093-3	2011	Furthermore, a solid-phase assay showed that the anti-AHc-C sera effectively inhibited the binding of AHc or AHc-C to the ganglioside GT1b, the first step in BoNT/A intoxication of neurons, as good as the anti-AHc sera.	Gangliosides	122-133	nuclear receptor subfamily 0, group B, member 1	Mus musculus	102-105
21941093-3	2011	Furthermore, a solid-phase assay showed that the anti-AHc-C sera effectively inhibited the binding of AHc or AHc-C to the ganglioside GT1b, the first step in BoNT/A intoxication of neurons, as good as the anti-AHc sera.	Gangliosides	122-133	nuclear receptor subfamily 0, group B, member 1	Mus musculus	102-105
21941093-3	2011	Furthermore, a solid-phase assay showed that the anti-AHc-C sera effectively inhibited the binding of AHc or AHc-C to the ganglioside GT1b, the first step in BoNT/A intoxication of neurons, as good as the anti-AHc sera.	Gangliosides	122-133	nuclear receptor subfamily 0, group B, member 1	Mus musculus	102-105
21288691-7	2011	RESULTS: Total lipid-bound sialic acid of human milk gangliosides after preterm delivery showed a peak concentration at 2 to 3 d postpartum and then remained at a high concentration until approximately 10 d. GD3 was the major ganglioside in the colostrum until approximately 7 to 10 d postpartum.	Gangliosides	53-64	GRDX	Homo sapiens	208-211
21203834-0	2011	Regulation of epidermal growth factor receptor through interaction of ganglioside GM3 with GlcNAc of N-linked glycan of the receptor: demonstration in ldlD cells.	Gangliosides	70-81	epidermal growth factor receptor	Cricetulus griseus	14-46
21872576-0	2011	Ganglioside mediate the interaction between Nogo receptor 1 and LINGO-1.	Gangliosides	0-11	reticulon 4	Homo sapiens	44-48
21872576-0	2011	Ganglioside mediate the interaction between Nogo receptor 1 and LINGO-1.	Gangliosides	0-11	leucine rich repeat and Ig domain containing 1	Homo sapiens	64-71
21872576-2	2011	We employed a cell-free system to study the binding of NgR1 to its co-receptors and the myelin inhibitor Nogo-A, and show that gangliosides mediate the interaction of NgR1 with LINGO-1.	Gangliosides	127-139	reticulon 4	Homo sapiens	105-111
21872576-2	2011	We employed a cell-free system to study the binding of NgR1 to its co-receptors and the myelin inhibitor Nogo-A, and show that gangliosides mediate the interaction of NgR1 with LINGO-1.	Gangliosides	127-139	leucine rich repeat and Ig domain containing 1	Homo sapiens	177-184
21872576-4	2011	Moreover, the tripartite complex comprising of NgR1, LINGO-1 and ganglioside exhibits stronger binding to Nogo-A (Nogo-54) in the presence of p75, suggesting the gangliosides modulate the myelin inhibitor-receptor signaling.	Gangliosides	65-76	reticulon 4	Homo sapiens	106-112
21872576-4	2011	Moreover, the tripartite complex comprising of NgR1, LINGO-1 and ganglioside exhibits stronger binding to Nogo-A (Nogo-54) in the presence of p75, suggesting the gangliosides modulate the myelin inhibitor-receptor signaling.	Gangliosides	65-76	reticulon 4	Homo sapiens	106-110
21872576-4	2011	Moreover, the tripartite complex comprising of NgR1, LINGO-1 and ganglioside exhibits stronger binding to Nogo-A (Nogo-54) in the presence of p75, suggesting the gangliosides modulate the myelin inhibitor-receptor signaling.	Gangliosides	65-76	PC4 and SFRS1 interacting protein 1	Homo sapiens	142-145
21872576-4	2011	Moreover, the tripartite complex comprising of NgR1, LINGO-1 and ganglioside exhibits stronger binding to Nogo-A (Nogo-54) in the presence of p75, suggesting the gangliosides modulate the myelin inhibitor-receptor signaling.	Gangliosides	162-174	leucine rich repeat and Ig domain containing 1	Homo sapiens	53-60
21872576-4	2011	Moreover, the tripartite complex comprising of NgR1, LINGO-1 and ganglioside exhibits stronger binding to Nogo-A (Nogo-54) in the presence of p75, suggesting the gangliosides modulate the myelin inhibitor-receptor signaling.	Gangliosides	162-174	reticulon 4	Homo sapiens	106-112
21872576-4	2011	Moreover, the tripartite complex comprising of NgR1, LINGO-1 and ganglioside exhibits stronger binding to Nogo-A (Nogo-54) in the presence of p75, suggesting the gangliosides modulate the myelin inhibitor-receptor signaling.	Gangliosides	162-174	reticulon 4	Homo sapiens	106-110
21872576-4	2011	Moreover, the tripartite complex comprising of NgR1, LINGO-1 and ganglioside exhibits stronger binding to Nogo-A (Nogo-54) in the presence of p75, suggesting the gangliosides modulate the myelin inhibitor-receptor signaling.	Gangliosides	162-174	PC4 and SFRS1 interacting protein 1	Homo sapiens	142-145
21786792-6	2011	Two populations of CTB with markedly different drift velocity could be identified, which from dissociation kinetics data were attributed to CTB bound with different numbers of ganglioside anchors.	Gangliosides	176-187	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	19-22
21253856-6	2011	The content of total sialic acid and levels of gangliosides GM3, GM2, and GD3 were greater in the whole brains of Idua-/- mice then in Idua (+/?)	Gangliosides	47-59	granulocyte macrophage antigen 3	Mus musculus	60-63
21253856-9	2011	The accumulation of ganglioside GD3 suggests that neurodegeneration occurs in the Idua-/-) mouse brain, but not to the extent seen in human MPS IH brain.	Gangliosides	20-31	iduronidase, alpha-L	Mus musculus	82-86
21399908-4	2011	The present study provides evidence that brain ganglioside abnormality, in particular GM1, may be involved.	Gangliosides	47-58	coenzyme Q10A	Mus musculus	86-89
21807667-1	2011	The expression of ganglioside GD3, which plays crucial roles in normal brain development, decreases in adults but is upregulated in neoplastic cells, where it regulates tumor invasion and survival.	Gangliosides	18-29	GRDX	Homo sapiens	30-33
21860602-0	2011	Rapid Profiling of Bovine and Human Milk Gangliosides by Matrix-Assisted Laser Desorption/Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.	Gangliosides	41-53	Weaning weight-maternal milk	Bos taurus	36-40
21784073-1	2011	Recently, we identified ganglioside GM2 activator protein (GM2AP) as a novel adipokine, and revealed that treatment of cultured cells with GM2AP impairs insulin signal transduction.	Gangliosides	24-35	GM2 ganglioside activator protein	Mus musculus	36-57
21784073-1	2011	Recently, we identified ganglioside GM2 activator protein (GM2AP) as a novel adipokine, and revealed that treatment of cultured cells with GM2AP impairs insulin signal transduction.	Gangliosides	24-35	GM2 ganglioside activator protein	Mus musculus	59-64
21784073-1	2011	Recently, we identified ganglioside GM2 activator protein (GM2AP) as a novel adipokine, and revealed that treatment of cultured cells with GM2AP impairs insulin signal transduction.	Gangliosides	24-35	GM2 ganglioside activator protein	Mus musculus	139-144
21860602-3	2011	In milk, gangliosides are exclusively associated with the milk fat globule membrane.	Gangliosides	9-21	Weaning weight-maternal milk	Bos taurus	3-7
21860602-3	2011	In milk, gangliosides are exclusively associated with the milk fat globule membrane.	Gangliosides	9-21	Weaning weight-maternal milk	Bos taurus	58-62
21860602-6	2011	Here, we describe a rapid profiling method for bovine and human milk gangliosides employing matrix-assisted desorption/ionization (MALDI) Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS).	Gangliosides	69-81	Weaning weight-maternal milk	Bos taurus	64-68
21860602-10	2011	Complex ganglioside mixtures from bovine and human milk were further analyzed with this method.	Gangliosides	8-19	Weaning weight-maternal milk	Bos taurus	51-55
21860602-13	2011	The common gangliosides in bovine and human milk are NeuAc-NeuAc-Hex-Hex-Cer (GD3) and NeuAc-Hex-Hex-Cer (GM3); whereas, the ion intensities of ganglioside species are different between two milk samples.	Gangliosides	11-23	Weaning weight-maternal milk	Bos taurus	44-48
21860602-13	2011	The common gangliosides in bovine and human milk are NeuAc-NeuAc-Hex-Hex-Cer (GD3) and NeuAc-Hex-Hex-Cer (GM3); whereas, the ion intensities of ganglioside species are different between two milk samples.	Gangliosides	11-23	GRDX	Homo sapiens	78-81
21860602-13	2011	The common gangliosides in bovine and human milk are NeuAc-NeuAc-Hex-Hex-Cer (GD3) and NeuAc-Hex-Hex-Cer (GM3); whereas, the ion intensities of ganglioside species are different between two milk samples.	Gangliosides	11-22	Weaning weight-maternal milk	Bos taurus	44-48
21860602-13	2011	The common gangliosides in bovine and human milk are NeuAc-NeuAc-Hex-Hex-Cer (GD3) and NeuAc-Hex-Hex-Cer (GM3); whereas, the ion intensities of ganglioside species are different between two milk samples.	Gangliosides	11-22	GRDX	Homo sapiens	78-81
21860602-13	2011	The common gangliosides in bovine and human milk are NeuAc-NeuAc-Hex-Hex-Cer (GD3) and NeuAc-Hex-Hex-Cer (GM3); whereas, the ion intensities of ganglioside species are different between two milk samples.	Gangliosides	11-22	Weaning weight-maternal milk	Bos taurus	190-194
21860602-16	2011	We found that only in human milk gangliosides was the ceramide carbon always even numbered, which is consistent with the notion that differences in the oligosaccharide and the ceramide moieties confer to their physiological distinctions.	Gangliosides	33-45	Weaning weight-maternal milk	Bos taurus	28-32
21554929-0	2011	Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells.	Gangliosides	0-11	hepatocyte growth factor	Mus musculus	38-62
21723256-10	2011	Up-regulation of Wisp2/CCN5 in GM3-only mice should be, therefore, a reaction to protect nervous tissues from neurodegeneration caused by ganglioside deficiency.	Gangliosides	138-149	cellular communication network factor 5	Mus musculus	17-22
21723256-10	2011	Up-regulation of Wisp2/CCN5 in GM3-only mice should be, therefore, a reaction to protect nervous tissues from neurodegeneration caused by ganglioside deficiency.	Gangliosides	138-149	cellular communication network factor 5	Mus musculus	23-27
21708114-0	2011	Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C. Niemann-Pick disease type C (NPC) is a severe neurovisceral lysosomal storage disorder caused by defects in NPC1 or NPC2 proteins.	Gangliosides	34-46	NPC intracellular cholesterol transporter 1	Mus musculus	230-234
21708114-0	2011	Endosomal/lysosomal processing of gangliosides affects neuronal cholesterol sequestration in Niemann-Pick disease type C. Niemann-Pick disease type C (NPC) is a severe neurovisceral lysosomal storage disorder caused by defects in NPC1 or NPC2 proteins.	Gangliosides	34-46	NPC intracellular cholesterol transporter 2	Mus musculus	238-242
21708114-1	2011	Although numerous studies support the primacy of cholesterol storage, neurons of double-mutant mice lacking both NPC1 and an enzyme required for synthesis of all complex gangliosides (beta1,4GalNAc transferase) have been reported to exhibit dramatically reduced cholesterol sequestration.	Gangliosides	170-182	NPC intracellular cholesterol transporter 1	Mus musculus	113-117
21708114-6	2011	Unexpectedly, GM1 accumulation in double mutants increased compared to single mutants consistent with a direct role for NPC1 in ganglioside salvage.	Gangliosides	128-139	NPC intracellular cholesterol transporter 1	Mus musculus	120-124
21554929-0	2011	Ganglioside GD1a negatively regulates hepatocyte growth factor expression through caveolin-1 at the transcriptional level in murine osteosarcoma cells.	Gangliosides	0-11	caveolin 1, caveolae protein	Mus musculus	82-92
21554929-7	2011	Treatment with siRNAs directed toward GM2/GD2 synthase in FBJ-S1 cells reduced gangliosides and augmented HGF expression.	Gangliosides	79-91	cytochrome b5 domain containing 2	Mus musculus	38-41
21554929-8	2011	GD1a was found to be the only ganglioside species suppressing HGF expression upon addition to FBJ-LL cells.	Gangliosides	30-41	hepatocyte growth factor	Mus musculus	62-65
21554929-14	2011	GENERAL SIGNIFICANCE: This is the first report that ganglioside GD1a negatively regulates HGF expression through caveolin-1.	Gangliosides	52-63	hepatocyte growth factor	Mus musculus	90-93
21554929-14	2011	GENERAL SIGNIFICANCE: This is the first report that ganglioside GD1a negatively regulates HGF expression through caveolin-1.	Gangliosides	52-63	caveolin 1, caveolae protein	Mus musculus	113-123
21750187-4	2011	When the GFP-labeled sperm were treated with compounds for promoting the acrosome reaction, EGFP-GPI was released from the sperm surface crosslinked with characteristic relocation of a lipid raft marker ganglioside GM1.	Gangliosides	203-214	coenzyme Q10A	Mus musculus	215-218
21699754-1	2011	The present study demonstrated that valproic acid (VPA) transcriptionally regulates human GM3 synthase (hST3Gal V), which catalyzes ganglioside GM3 biosynthesis in ARPE-19 human retinal pigment epithelial cells.	Gangliosides	132-143	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	90-102
21870425-2	2011	Immuno-histological studies with von Willebrand Factor (vWF) antibody indicated that tumor angiogenesis as determined by expression of vWF decreased in tumors of mice, post-immunized with EAC-cell gangliosides as well as its anti-idiotype antibody.	Gangliosides	197-209	Von Willebrand factor	Mus musculus	56-59
21870425-2	2011	Immuno-histological studies with von Willebrand Factor (vWF) antibody indicated that tumor angiogenesis as determined by expression of vWF decreased in tumors of mice, post-immunized with EAC-cell gangliosides as well as its anti-idiotype antibody.	Gangliosides	197-209	Von Willebrand factor	Mus musculus	135-138
21870425-5	2011	Cell cycle analysis by FACS indicated that EAC-cell associated gangliosides and its anti-idiotype antibody were acting both at the M2 i.e. S and M3 i.e. G2/M phases of the cell cycle to arrest tumor growth.	Gangliosides	63-75	acyl-CoA synthetase long-chain family member 1	Mus musculus	23-27
21928695-2	2011	Here, we examined the effectiveness of anti-ganglioside antibody generation by immunization of beta3Gn-T5 mutant mice with liposome-embedded glycosphingolipids such as GD1a and GT1b.	Gangliosides	44-55	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Mus musculus	95-105
21632541-4	2011	In this study BoNT/D is shown to have a unique association with ganglioside relative to the other BoNT serotypes, utilizing a ganglioside binding loop (GBL, residues Tyr-1235-Ala-1245) within the receptor binding domain of BoNT/D (HCR/D) via b-series gangliosides, including GT1b, GD1b, and GD2.	Gangliosides	64-75	coiled-coil alpha-helical rod protein 1	Homo sapiens	231-234
21632541-4	2011	In this study BoNT/D is shown to have a unique association with ganglioside relative to the other BoNT serotypes, utilizing a ganglioside binding loop (GBL, residues Tyr-1235-Ala-1245) within the receptor binding domain of BoNT/D (HCR/D) via b-series gangliosides, including GT1b, GD1b, and GD2.	Gangliosides	126-137	coiled-coil alpha-helical rod protein 1	Homo sapiens	231-234
21632541-5	2011	HCR/D bound gangliosides and entered neurons dependent upon the aromatic ring of Phe-1240 within the GBL.	Gangliosides	12-24	coiled-coil alpha-helical rod protein 1	Homo sapiens	0-3
21682276-3	2011	We have proposed that ganglioside clusters in lipid rafts mediate the formation of amyloid fibrils by Abeta, the toxicity and physicochemical properties of which are different from those of amyloids formed in solution.	Gangliosides	22-33	amyloid beta precursor protein	Homo sapiens	102-107
21632551-4	2011	Here we describe roles of the melanoma antigen ganglioside GD3 and phosphatidylinositol 3-kinase (PI3K)-Akt-mTOR complex 1 (mTORC1) signaling in the regulation of SREBP activity, cholesterol biosynthesis, and the integrity of lipid rafts in human melanoma cells.	Gangliosides	47-58	GRDX	Homo sapiens	59-62
21699754-1	2011	The present study demonstrated that valproic acid (VPA) transcriptionally regulates human GM3 synthase (hST3Gal V), which catalyzes ganglioside GM3 biosynthesis in ARPE-19 human retinal pigment epithelial cells.	Gangliosides	132-143	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	104-114
21571640-5	2011	Here, the ganglioside GM3 but not other related lipids strongly inhibited the autophosphorylation of the EGFR kinase domain.	Gangliosides	10-21	epidermal growth factor receptor	Homo sapiens	105-109
20971126-0	2011	Exogenous gangliosides increase the release of brain-derived neurotrophic factor.	Gangliosides	10-22	brain derived neurotrophic factor	Homo sapiens	47-80
21376833-3	2011	Using detergent-resistant membrane (DRM) assays, as well as transmembrane (TM) interactions and ganglioside GM1 binding, we present evidence supporting the localization of podoplanin in raft platforms important for cell signalling.	Gangliosides	96-107	podoplanin	Canis lupus familiaris	172-182
21333627-1	2011	The ganglioside GM3 synthase (SAT-I), encoded by a single-copy gene, is a primary glycosyltransferase for the synthesis of complex gangliosides.	Gangliosides	131-143	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	4-28
21454696-0	2011	Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.	Gangliosides	141-152	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	25-28
21454696-0	2011	Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3.	Gangliosides	141-152	GRDX	Homo sapiens	153-156
21396938-7	2011	This effect was not observed with phosphatidylcholine monolayers, suggesting that the ganglioside facilitated the insertion of alpha-synuclein into raft-like membrane domains.	Gangliosides	86-97	synuclein alpha	Homo sapiens	127-142
21334356-0	2011	Gangliosides inhibit bee venom melittin cytotoxicity but not phospholipase A(2)-induced degranulation in mast cells.	Gangliosides	0-12	melittin	Apis mellifera	31-39
21334356-11	2011	Taken together, gangliosides inhibit the effect of melittin such as degranulation, cytotoxicity and lipid raft disruption but not phospholipase A(2)-induced degranulation in mast cells.	Gangliosides	16-28	melittin	Apis mellifera	51-59
21395555-0	2011	Expression of GD2 and GD3 gangliosides in human embryonic neural stem cells.	Gangliosides	26-38	GRDX	Homo sapiens	22-25
21395555-2	2011	It has been recently reported that GD3, a b-series ganglioside, is a marker molecule for identifying and isolating mouse NSCs.	Gangliosides	51-62	GRDX	Homo sapiens	35-38
21395555-8	2011	Our study suggests that GD2 and GD3 can be marker gangliosides for identifying human NSCs.	Gangliosides	50-62	GRDX	Homo sapiens	32-35
21306777-4	2011	Heavy chain CDR3 (H-CDR3) arginine residues have been shown to be crucial for ganglioside recognition, but less important for anti-idiotypic antibody binding.	Gangliosides	78-89	CDR3	Homo sapiens	12-16
21306777-4	2011	Heavy chain CDR3 (H-CDR3) arginine residues have been shown to be crucial for ganglioside recognition, but less important for anti-idiotypic antibody binding.	Gangliosides	78-89	CDR3	Homo sapiens	18-24
20971126-6	2011	In particular, we examined whether gangliosides promote the release of BDNF.	Gangliosides	35-47	brain derived neurotrophic factor	Homo sapiens	71-75
20971126-11	2011	In human cells, GM1 and other gangliosides released both mature BDNF and pro-BDNF.	Gangliosides	30-42	brain derived neurotrophic factor	Homo sapiens	64-68
20971126-11	2011	In human cells, GM1 and other gangliosides released both mature BDNF and pro-BDNF.	Gangliosides	30-42	brain derived neurotrophic factor	Homo sapiens	77-81
20971126-15	2011	This work provides additional experimental evidence that exogenous gangliosides can be used to enhance the neurotrophic factor environment and promote neuronal survival in neurological diseases.	Gangliosides	67-79	neurotrophin 3	Homo sapiens	107-126
21492147-6	2011	During osteoblastic differentiation, the increased ALP activity remarkably reduced by suppression of ganglioside GD1a expression by ST3Gal II shRNA.	Gangliosides	101-112	alkaline phosphatase, placental	Homo sapiens	51-54
21492147-6	2011	During osteoblastic differentiation, the increased ALP activity remarkably reduced by suppression of ganglioside GD1a expression by ST3Gal II shRNA.	Gangliosides	101-112	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Homo sapiens	132-141
21492147-9	2011	These results suggest that ganglioside GD1a plays an important role in the regulation of osteoblastic differentiation of hMSCs through the activation of ERK 1/2 MAP kinase and EGFR.	Gangliosides	27-38	mitogen-activated protein kinase 3	Homo sapiens	153-160
21492147-9	2011	These results suggest that ganglioside GD1a plays an important role in the regulation of osteoblastic differentiation of hMSCs through the activation of ERK 1/2 MAP kinase and EGFR.	Gangliosides	27-38	epidermal growth factor receptor	Homo sapiens	176-180
21329670-6	2011	Furthermore, extracted breast cancer cell gangliosides supported binding of E-selectin-Ig chimera and adhesion of E-selectin transfected cells under physiological flow conditions.	Gangliosides	42-54	selectin E	Homo sapiens	114-124
21329670-7	2011	In summary, our results demonstrate that breast cancer cells express sialylated glycosphingolipids (gangliosides) as E-selectin ligands that may be targeted for prevention of metastasis.	Gangliosides	100-112	selectin E	Homo sapiens	117-127
21329670-0	2011	Gangliosides expressed on breast cancer cells are E-selectin ligands.	Gangliosides	0-12	selectin E	Homo sapiens	50-60
20831659-0	2011	Ganglioside-mediated aggregation of amyloid beta-proteins (Abeta): comparison between Abeta-(1-42) and Abeta-(1-40).	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	59-64
21329670-6	2011	Furthermore, extracted breast cancer cell gangliosides supported binding of E-selectin-Ig chimera and adhesion of E-selectin transfected cells under physiological flow conditions.	Gangliosides	42-54	selectin E	Homo sapiens	76-86
21655440-0	2011	The hematopoietic stem cell polarization and migration: A dynamic link between RhoA signaling pathway, microtubule network and ganglioside-based membrane microdomains.	Gangliosides	127-138	ras homolog family member A	Homo sapiens	79-83
20831659-0	2011	Ganglioside-mediated aggregation of amyloid beta-proteins (Abeta): comparison between Abeta-(1-42) and Abeta-(1-40).	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	86-91
20831659-0	2011	Ganglioside-mediated aggregation of amyloid beta-proteins (Abeta): comparison between Abeta-(1-42) and Abeta-(1-40).	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	86-91
21214566-2	2011	The quantity and expression pattern of gangliosides in brain change drastically during early development and are mainly regulated through stage-specific expression of glycosyltransferase (ganglioside synthase) genes.	Gangliosides	39-51	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	167-186
20831659-3	2011	We have proposed that Abeta-(1-40) specifically bound to a ganglioside cluster forms cytotoxic fibrils via a conformational transition from an alpha-helix-rich structure to a beta-sheet-rich one.	Gangliosides	59-70	amyloid beta precursor protein	Homo sapiens	22-27
21214549-2	2011	A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain.	Gangliosides	61-72	amyloid beta precursor protein	Homo sapiens	46-51
21214549-2	2011	A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain.	Gangliosides	61-72	amyloid beta precursor protein	Homo sapiens	189-194
21214549-2	2011	A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain.	Gangliosides	61-72	alpha glucosidase	Homo sapiens	196-202
21214549-2	2011	A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain.	Gangliosides	171-182	amyloid beta precursor protein	Homo sapiens	46-51
21214566-8	2011	Our studies provide the first evidence that efficient histone acetylation of the glycosyltransferase genes in mouse brain contributes to the developmental alteration of ganglioside expression.	Gangliosides	169-180	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	81-100
21214549-2	2011	A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain.	Gangliosides	171-182	amyloid beta precursor protein	Homo sapiens	189-194
21214549-2	2011	A body of evidence is growing to suggest that Abeta binds to ganglioside on neuronal membranes, and then, is converted to an endogenous seed with an altered conformation (ganglioside-bound Abeta, GAbeta) for amyloid fibril formation in the brain.	Gangliosides	171-182	alpha glucosidase	Homo sapiens	196-202
21214573-1	2011	We have demonstrated that antibody to ganglioside GD3 (R24) immunoprecipitates src-family tyrosine kinase Lyn from primary cerebellar granule cells and R24 treatment of the intact cells induces Lyn activation and rapid tyrosine phosphorylation of several substrates, suggesting the functional association of ganglioside GD3 with Lyn.	Gangliosides	38-49	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	106-109
21274438-2	2011	It has been suggested that Abeta induces changes in neuronal membrane fluidity as a result of its interactions with membrane components such as cholesterol, phospholipids, and gangliosides.	Gangliosides	176-188	amyloid beta (A4) precursor protein	Mus musculus	27-32
21214573-1	2011	We have demonstrated that antibody to ganglioside GD3 (R24) immunoprecipitates src-family tyrosine kinase Lyn from primary cerebellar granule cells and R24 treatment of the intact cells induces Lyn activation and rapid tyrosine phosphorylation of several substrates, suggesting the functional association of ganglioside GD3 with Lyn.	Gangliosides	38-49	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	194-197
21214573-1	2011	We have demonstrated that antibody to ganglioside GD3 (R24) immunoprecipitates src-family tyrosine kinase Lyn from primary cerebellar granule cells and R24 treatment of the intact cells induces Lyn activation and rapid tyrosine phosphorylation of several substrates, suggesting the functional association of ganglioside GD3 with Lyn.	Gangliosides	38-49	LYN proto-oncogene, Src family tyrosine kinase	Mus musculus	194-197
21226491-4	2011	The cellular CTB-receptor, ganglioside GM1, contains a pentasaccharide moiety consisting in part of galactose and glucose units.	Gangliosides	27-38	phosphate cytidylyltransferase 1B, choline	Homo sapiens	13-16
21318142-4	2011	This paper summarizes the molecular mechanisms by which Abeta aggregates on membranes containing ganglioside clusters, forming amyloid fibrils.	Gangliosides	97-108	amyloid beta precursor protein	Homo sapiens	56-61
21214549-3	2011	Notably, the risk factors for the development of AD, including aging and apolipoprotein E4, likely facilitate the formation of ganglioside clusters in lipid raft-like membrane microdomains at pre-synaptic terminals, which provide a favorable milieu for the GAbeta generation.	Gangliosides	127-138	apolipoprotein E	Homo sapiens	73-90
21214549-3	2011	Notably, the risk factors for the development of AD, including aging and apolipoprotein E4, likely facilitate the formation of ganglioside clusters in lipid raft-like membrane microdomains at pre-synaptic terminals, which provide a favorable milieu for the GAbeta generation.	Gangliosides	127-138	alpha glucosidase	Homo sapiens	257-263
21214549-5	2011	In this review, the nature of the ganglioside clusters and how gangliosides behave in the clusters leading to the GAbeta generation are discussed.	Gangliosides	34-45	alpha glucosidase	Homo sapiens	114-120
21214549-5	2011	In this review, the nature of the ganglioside clusters and how gangliosides behave in the clusters leading to the GAbeta generation are discussed.	Gangliosides	63-75	alpha glucosidase	Homo sapiens	114-120
21289175-0	2011	Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth.	Gangliosides	5-16	ras homolog family member A	Homo sapiens	49-53
21289175-9	2011	Our results show that the Ab-mediated inhibition of neurite outgrowth involves the activation of RhoA and ROCK pathway and this activation is through the engagement of specific cell-surface gangliosides by Abs.	Gangliosides	190-202	ras homolog family member A	Homo sapiens	97-101
21134719-3	2011	St8sia1 knockout mice, which lack b- and c-series gangliosides, exhibit altered nociceptive responses.	Gangliosides	50-62	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	0-7
21134719-14	2011	Ganglioside GT1b induced extracellular glutamate to accumulate in subdermal tissues, thereafter activating glutamate receptors, which in turn resulted in hyperalgesia and nociception.	Gangliosides	0-11	retinoic acid induced 1	Mus musculus	12-15
21274438-3	2011	Gangliosides are known to bind Abeta.	Gangliosides	0-12	amyloid beta (A4) precursor protein	Mus musculus	31-36
21481337-3	2011	Visualization of the cross-linked ganglioside(M1) (GM(1)) using fluorescent labeled CTB, indicated accumulation of the fluorescence to one cap and a few smaller patches in both type of cells.	Gangliosides	34-45	phosphate cytidylyltransferase 1B, choline	Homo sapiens	84-87
21484572-0	2011	Inhibition of ganglioside biosynthesis as a novel therapeutic approach in insulin resistance.	Gangliosides	14-25	insulin	Homo sapiens	74-81
21648307-0	2011	Dendritic morphology and spine density is not altered in motor cortex and dentate granular cells in mice lacking the ganglioside biosynthetic gene B4galnt1 - A quantitative Golgi cox study.	Gangliosides	117-128	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	147-155
21648344-12	2011	This study represents differences in the hepatic and pancreatic ganglioside phenotypes of three rat strains that could influence IGF and insulin secretion and action.	Gangliosides	64-75	insulin-like growth factor 1	Rattus norvegicus	129-132
21484572-2	2011	By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains microdomains and propose the new therapeutic strategy "membrane microdomain ortho-signaling therapy".	Gangliosides	179-191	insulin	Homo sapiens	103-110
22195039-5	2011	In the present study we used sialidase from Vibrio cholerae (VCS) to produce a brain ganglioside profile that approximates that of GD3S deletion.	Gangliosides	85-96	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	131-135
19233512-4	2011	In addition, we studied NMJs of old mice lacking GD3-synthase (expressing only O- and a-series gangliosides), which do not show an overt neurological phenotype but may develop subclinical synaptic deficits.	Gangliosides	95-107	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	49-61
19233512-7	2011	Interestingly, we observed faster kinetics of postsynaptic electrophysiological responses at aged GD3-synthase null-mutant NMJs, not previously seen by us at NMJs of young GD3-synthase null-mutants or other types of (aged or young) ganglioside-deficient mice.	Gangliosides	232-243	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	98-110
20875076-5	2011	Using this system, ganglioside treatment promotes the development of a dendritic cell population characterized by decreased CD86 (B7-2) expression, and decreased interleukin-12 and interleukin-6 production.	Gangliosides	19-30	CD86 antigen	Mus musculus	124-128
20875076-5	2011	Using this system, ganglioside treatment promotes the development of a dendritic cell population characterized by decreased CD86 (B7-2) expression, and decreased interleukin-12 and interleukin-6 production.	Gangliosides	19-30	interleukin 6	Mus musculus	181-194
21496400-3	2011	CD1-restricted T cells specific for gangliosides and sulfatide have been isolated from subjects with MS and in mice with experimental allergic encephalopathy.	Gangliosides	36-48	CD1 antigen complex	Mus musculus	0-3
21496400-4	2011	We genotyped exon 2 of CD1A and CD1E in 205 MS patients and 223 unrelated healthy controls and determined their association with the presence of anti-ganglioside and anti-sulfatide antibodies.	Gangliosides	150-161	CD1a molecule	Homo sapiens	23-27
21496400-4	2011	We genotyped exon 2 of CD1A and CD1E in 205 MS patients and 223 unrelated healthy controls and determined their association with the presence of anti-ganglioside and anti-sulfatide antibodies.	Gangliosides	150-161	CD1e molecule	Homo sapiens	32-36
22195039-6	2011	VCS hydrolyzes GD1a and complex b-series gangliosides to GM1, and the apoptogenic GD3 is degraded.	Gangliosides	41-53	coenzyme Q10A	Mus musculus	57-60
21629700-8	2011	Hampering ganglioside production by inhibiting the key enzyme glucosylceramide synthase did not abrogate the apoptotic process.	Gangliosides	10-21	UDP-glucose ceramide glucosyltransferase	Homo sapiens	62-87
22046448-0	2011	Erythropoietin enhances nerve repair in anti-ganglioside antibody-mediated models of immune neuropathy.	Gangliosides	45-56	erythropoietin	Homo sapiens	0-14
22046448-4	2011	We recently demonstrated that specific anti-ganglioside Abs inhibit axonal regeneration and nerve repair in preclinical models by activation of small GTPase RhoA and its downstream effectors.	Gangliosides	44-55	ras homolog family member A	Homo sapiens	157-161
22046448-6	2011	Primary neuronal cultures and a standardized sciatic crush nerve model were used to assess the efficacy of EPO in reversing inhibitory effects of anti-ganglioside Abs on nerve repair.	Gangliosides	151-162	erythropoietin	Homo sapiens	107-110
22046448-7	2011	We found that EPO completely reversed the inhibitory effects of anti-ganglioside Abs on axon regeneration in cell culture models and significantly improved nerve regeneration/repair in an animal model.	Gangliosides	69-80	erythropoietin	Homo sapiens	14-17
21558756-1	2011	Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3.	Gangliosides	123-135	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	49-61
21558756-1	2011	Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3.	Gangliosides	123-135	granulocyte macrophage antigen 3	Mus musculus	49-52
21558756-1	2011	Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3.	Gangliosides	263-275	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	49-61
21558756-1	2011	Since I was involved in the molecular cloning of GM3 synthase (SAT-I), which is the primary enzyme for the biosynthesis of gangliosides in 1998, my research group has been concentrating on our efforts to explore the physiological and pathological implications of gangliosides especially for GM3.	Gangliosides	263-275	granulocyte macrophage antigen 3	Mus musculus	49-52
21087515-2	2010	Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides.	Gangliosides	191-203	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Mus musculus	0-12
20720159-2	2010	Our previous study indicated that EMT processes of mouse and human epithelial cells induced by TGF-beta display clear reduction of gangliotetraosylceramide (Gg4) and ganglioside GM2, suggesting a close association of glycosphingolipids (GSLs) with EMT.	Gangliosides	166-177	transforming growth factor beta 1	Homo sapiens	95-103
20821051-1	2010	GM2 gangliosidosis type Sandhoff is caused by a defect of beta-hexosaminidase, an enzyme involved in the catabolism of gangliosides.	Gangliosides	119-131	O-GlcNAcase	Homo sapiens	58-77
21087515-2	2010	Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides.	Gangliosides	191-203	hemoglobin, beta adult major chain	Mus musculus	122-130
20889649-9	2010	Altogether, our results show that G(D3) synthase expression is sufficient to enhance the tumorigenicity of MDA-MB-231 breast cancer cells through a ganglioside-dependent activation of the c-Met receptor.	Gangliosides	148-159	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	188-193
20663960-0	2010	Ganglioside DSGb5, preferred ligand for Siglec-7, inhibits NK cell cytotoxicity against renal cell carcinoma cells.	Gangliosides	0-11	sialic acid binding Ig like lectin 7	Homo sapiens	40-48
21044592-4	2010	Using the ganglioside GM1 as a model GSL, and two mass-sensitive and label-free characterization techniques-quartz crystal microbalance with dissipation monitoring and ellipsometry-we demonstrate that GLTP is an efficient and robust biochemical tool to dynamically modulate the GSL content of SLBs up to 10 mol % GM1, and to quantitatively control the GSL content in the bulk-facing SLB leaflet.	Gangliosides	10-21	glycolipid transfer protein	Homo sapiens	201-205
20878014-4	2010	However, when neutrophils were stimulated by receptor-bypassing phorbol 12-myristate 13-acetate (PMA), gangliosides above their critical micellar concentrations prolonged the lag time preceding the production in a concentration-dependent way, without affecting total extracellular O2 - generation detected by superoxide dismutase-inhibitable cytochrome c reduction.	Gangliosides	103-115	cytochrome c, somatic	Homo sapiens	342-354
20930939-2	2010	Gangliosides, sialic acid-containing glycosphingolipids enriched in the nervous system and frequently used as biomarkers associated with the biochemical pathology of neurological disorders, have been suggested to be involved in the initial aggregation of Abeta.	Gangliosides	0-12	amyloid beta (A4) precursor protein	Mus musculus	255-260
20930939-6	2010	We interpret that the occurrence of these gangliosides may represent evidence for generation of cholinergic neurons in the AD brain, as a result of compensatory neurogenesis activated by the presence of Abeta.	Gangliosides	42-54	amyloid beta (A4) precursor protein	Mus musculus	203-208
20858456-6	2010	Although a ganglioside binding site has never been unambiguously identified in BoNT/D-HCR, a shallow cavity in an analogous location to the other BoNT serotypes HCR domains is observed in BoNT/D-HCR that has features compatible with membrane binding.	Gangliosides	11-22	coiled-coil alpha-helical rod protein 1	Homo sapiens	86-89
20679513-0	2010	Targeting ganglioside epitope 3G11 on the surface of CD4+ T cells suppresses EAE by altering the Treg/Th17 cell balance.	Gangliosides	10-21	CD4 antigen	Mus musculus	53-56
20679513-6	2010	As 3G11 belongs to the ganglioside family, which is expressed on the surface of both murine and human CD4(+) T cells, targeting this class of molecules may provide a novel approach for treating autoimmune diseases.	Gangliosides	23-34	CD4 molecule	Homo sapiens	102-105
20930481-5	2010	Our group demonstrated that amyloid formation by amyloid beta-protein (Abeta) was facilitated by gangliosides in lipid raft-like model membranes.	Gangliosides	97-109	amyloid beta precursor protein	Homo sapiens	71-76
20930481-10	2010	Abeta was accumulated on cholesterol-dependent ganglioside-rich domains in PC12 neuronal cells in a time- and concentration-dependent manner, leading to cell death.	Gangliosides	47-58	amyloid beta precursor protein	Rattus norvegicus	0-5
20930481-11	2010	Nerve growth factor-induced differentiation of PC12 cells increased both gangliosides and cholesterol and thereby greatly potentiated the accumulation and cytotoxic effect of Abeta.	Gangliosides	73-85	amyloid beta precursor protein	Rattus norvegicus	175-180
20930481-12	2010	Amyloid formation by hIAPP was also facilitated by gangliosides in lipid rafts.	Gangliosides	51-63	islet amyloid polypeptide	Homo sapiens	21-26
20639193-5	2010	In this work, we demonstrated that ecto-ganglioside glycosyltransferases may catalyze ganglioside synthesis outside the Golgi compartment, particularly at the cell surface.	Gangliosides	40-51	tripartite motif containing 33	Homo sapiens	35-39
20720456-7	2010	Interestingly, microRNA-based PIP5K alpha knockdown strongly reduced ganglioside-induced transcription of proinflammatory cytokines IL-1 beta and TNFalpha.	Gangliosides	69-80	interleukin 1 beta	Homo sapiens	132-141
20720456-7	2010	Interestingly, microRNA-based PIP5K alpha knockdown strongly reduced ganglioside-induced transcription of proinflammatory cytokines IL-1 beta and TNFalpha.	Gangliosides	69-80	tumor necrosis factor	Homo sapiens	146-154
20720456-8	2010	PIP5K alpha knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-kappaB and the degradation of I kappaB-alpha, indicating that PIP5K alpha knockdown interfered with the ganglioside-activated NF-kappaB signaling.	Gangliosides	38-49	nuclear factor kappa B subunit 1	Homo sapiens	103-112
20720456-8	2010	PIP5K alpha knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-kappaB and the degradation of I kappaB-alpha, indicating that PIP5K alpha knockdown interfered with the ganglioside-activated NF-kappaB signaling.	Gangliosides	38-49	NFKB inhibitor alpha	Homo sapiens	136-150
20720456-8	2010	PIP5K alpha knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-kappaB and the degradation of I kappaB-alpha, indicating that PIP5K alpha knockdown interfered with the ganglioside-activated NF-kappaB signaling.	Gangliosides	38-49	nuclear factor kappa B subunit 1	Homo sapiens	232-241
20720456-8	2010	PIP5K alpha knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-kappaB and the degradation of I kappaB-alpha, indicating that PIP5K alpha knockdown interfered with the ganglioside-activated NF-kappaB signaling.	Gangliosides	210-221	nuclear factor kappa B subunit 1	Homo sapiens	103-112
20720456-8	2010	PIP5K alpha knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-kappaB and the degradation of I kappaB-alpha, indicating that PIP5K alpha knockdown interfered with the ganglioside-activated NF-kappaB signaling.	Gangliosides	210-221	NFKB inhibitor alpha	Homo sapiens	136-150
20720456-8	2010	PIP5K alpha knockdown also suppressed ganglioside-induced phosphorylation and nuclear translocation of NF-kappaB and the degradation of I kappaB-alpha, indicating that PIP5K alpha knockdown interfered with the ganglioside-activated NF-kappaB signaling.	Gangliosides	210-221	nuclear factor kappa B subunit 1	Homo sapiens	232-241
20720456-9	2010	Together, these results suggest that PIP5K alpha is a novel inflammatory mediator that undergoes upregulation and contributes to immune responses by facilitating NF-kappaB activation in ganglioside-stimulated astrocytes.	Gangliosides	186-197	nuclear factor kappa B subunit 1	Homo sapiens	162-171
20554329-4	2010	Gangliosides induced iNOS/GFAP expression and NF-kappaB activation.	Gangliosides	0-12	nitric oxide synthase 2	Rattus norvegicus	21-25
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	Gangliosides	30-41	amyloid beta precursor protein	Rattus norvegicus	70-75
20862357-1	2010	Tay-Sachs disease is a severe lysosomal disorder caused by mutations in the HexA gene coding for the alpha-subunit of lysosomal beta-hexosaminidase A, which converts G(M2) to G(M3) ganglioside.	Gangliosides	181-192	hexosaminidase A	Mus musculus	76-80
20862357-1	2010	Tay-Sachs disease is a severe lysosomal disorder caused by mutations in the HexA gene coding for the alpha-subunit of lysosomal beta-hexosaminidase A, which converts G(M2) to G(M3) ganglioside.	Gangliosides	181-192	O-GlcNAcase	Mus musculus	128-147
20862357-2	2010	Hexa(-/-) mice, depleted of beta-hexosaminidase A, remain asymptomatic to 1 year of age, because they catabolise G(M2) ganglioside via a lysosomal sialidase into glycolipid G(A2), which is further processed by beta-hexosaminidase B to lactosyl-ceramide, thereby bypassing the beta-hexosaminidase A defect.	Gangliosides	119-130	hexosaminidase A	Mus musculus	0-4
20862357-4	2010	Previously, we identified a novel ganglioside metabolizing sialidase, Neu4, abundantly expressed in mouse brain neurons.	Gangliosides	34-45	sialidase 4	Mus musculus	70-74
20554329-4	2010	Gangliosides induced iNOS/GFAP expression and NF-kappaB activation.	Gangliosides	0-12	glial fibrillary acidic protein	Rattus norvegicus	26-30
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	Gangliosides	30-41	alpha glucosidase	Rattus norvegicus	78-84
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	Gangliosides	30-41	alpha glucosidase	Rattus norvegicus	163-169
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	Gangliosides	264-275	amyloid beta precursor protein	Rattus norvegicus	70-75
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	Gangliosides	264-275	alpha glucosidase	Rattus norvegicus	78-84
20599476-2	2010	Previous studies suggest that ganglioside-bound amyloid beta-protein (Abeta), GAbeta, is an endogenous seed for amyloid in Alzheimer"s disease (AD) brain and that GAbeta is generated in the membrane microdomains, comprising cholesterol, sphingomyelin (SM) and GM1 ganglioside.	Gangliosides	264-275	alpha glucosidase	Rattus norvegicus	163-169
20518744-1	2010	Gene expression of the human plasma membrane-associated sialidase (NEU3), a key enzyme for ganglioside degradation, is relatively high in brain and is modulated in response to many cellular processes, including neuronal cell differentiation and tumorigenesis.	Gangliosides	91-102	neuraminidase 3	Homo sapiens	29-71
20581115-0	2010	Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
20581115-1	2010	Ganglioside GD3 is widely expressed in human malignant melanoma cell lines and tumors.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
20117237-0	2010	Abeta polymerization through interaction with membrane gangliosides.	Gangliosides	55-67	amyloid beta precursor protein	Homo sapiens	0-5
20117237-3	2010	The ganglioside-bound Abeta (GAbeta) possessed unique characteristics, including its altered immunoreactivity, which suggests its distinct conformation from native Abeta, and its strong potency to accelerate Abeta assembly into fibrils.	Gangliosides	4-15	alpha glucosidase	Homo sapiens	29-35
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-101	alpha glucosidase	Homo sapiens	49-55
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-101	amyloid beta precursor protein	Homo sapiens	50-55
20117237-3	2010	The ganglioside-bound Abeta (GAbeta) possessed unique characteristics, including its altered immunoreactivity, which suggests its distinct conformation from native Abeta, and its strong potency to accelerate Abeta assembly into fibrils.	Gangliosides	4-15	amyloid beta precursor protein	Homo sapiens	22-27
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-101	alpha glucosidase	Homo sapiens	194-200
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-101	amyloid beta precursor protein	Homo sapiens	74-79
20117237-3	2010	The ganglioside-bound Abeta (GAbeta) possessed unique characteristics, including its altered immunoreactivity, which suggests its distinct conformation from native Abeta, and its strong potency to accelerate Abeta assembly into fibrils.	Gangliosides	4-15	amyloid beta precursor protein	Homo sapiens	30-35
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-100	alpha glucosidase	Homo sapiens	49-55
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-100	amyloid beta precursor protein	Homo sapiens	50-55
20423299-4	2010	Abeta induced changes in membrane fluidity could be explained by physico-chemical interactions of the peptide with membrane components such as cholesterol, phospholipids and gangliosides.	Gangliosides	174-186	amyloid beta precursor protein	Homo sapiens	0-5
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-100	alpha glucosidase	Homo sapiens	194-200
20117237-5	2010	To date, various in vitro and in vivo studies on GAbeta have revealed how Abeta binds to gangliosides, i.e., what are the favorable physicochemical and neurobiological conditions for generating GAbeta, and what is the pathological significance of ganglioside-induced Abeta assembly in the development of AD.	Gangliosides	89-100	amyloid beta precursor protein	Homo sapiens	74-79
20117237-6	2010	Interestingly, GAbeta is favorably generated in the unique ganglioside-enriched (clustered), raft-like microdomains; moreover, amyloid fibrils formed in the presence of gangliosides are neurotoxic.	Gangliosides	59-70	alpha glucosidase	Homo sapiens	15-21
20117237-6	2010	Interestingly, GAbeta is favorably generated in the unique ganglioside-enriched (clustered), raft-like microdomains; moreover, amyloid fibrils formed in the presence of gangliosides are neurotoxic.	Gangliosides	169-181	alpha glucosidase	Homo sapiens	15-21
20117237-7	2010	Furthermore, the conformational change of Abeta in the presence of ganglioside has been characterized by an NMR study.	Gangliosides	67-78	amyloid beta precursor protein	Homo sapiens	42-47
20117237-8	2010	In this review, we focus on the recent progress of GAbeta studies and highlight the possibility that ganglioside binding is the initial and common step in the development of a part of human misfolding-type amyloidoses, including AD.	Gangliosides	101-112	alpha glucosidase	Homo sapiens	51-57
20616019-0	2010	Overexpression of ST6GalNAcV, a ganglioside-specific alpha2,6-sialyltransferase, inhibits glioma growth in vivo.	Gangliosides	32-43	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	Homo sapiens	18-28
20589721-0	2010	Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells.	Gangliosides	0-11	nitric oxide synthase 2, inducible	Mus musculus	32-36
20589721-0	2010	Ganglioside GD1a suppression of NOS2 expression via ERK1 pathway in mouse osteosarcoma FBJ cells.	Gangliosides	0-11	mitogen-activated protein kinase 3	Mus musculus	52-56
20616019-5	2010	ST6GalNAcV catalyzes the formation of the terminal alpha2,6-sialic acid linkages on gangliosides.	Gangliosides	84-96	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 5	Homo sapiens	0-10
20427129-2	2010	In the present study, therefore, the effects of the inhibition of glucosylceramide synthase, the key enzyme of ganglioside synthesis, were studied on chemically defined populations and on the activation of TRPV1 of cultured adult rat sensory ganglion neurons.	Gangliosides	111-122	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	66-91
20409738-2	2010	Its main gene product, human acid beta-galactosidase (beta-Gal) degrades two functionally important molecules, G(M1)-ganglioside and keratan sulfate in brain and connective tissues, respectively.	Gangliosides	117-128	galactosidase beta 1	Homo sapiens	29-52
20409738-2	2010	Its main gene product, human acid beta-galactosidase (beta-Gal) degrades two functionally important molecules, G(M1)-ganglioside and keratan sulfate in brain and connective tissues, respectively.	Gangliosides	117-128	galactosidase beta 1	Homo sapiens	54-62
20427129-9	2010	The present observations demonstrate that inhibition of neuronal ganglioside synthesis profoundly modulates the expression of the TRPV1 receptor, apparently leaving other markers of nociceptive neurons, such as CGRP and IB4, unaffected.	Gangliosides	65-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	130-135
20427129-10	2010	The findings indicate that as yet unidentified ganglioside(s) synthesized by the glucosylceramide synthase pathway may be essential for nociception through mechanisms which may implicate membrane lipid raft function and/or altered nerve growth factor signaling, which are essential for the TRPV1 receptor function.	Gangliosides	47-58	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	81-106
20547865-5	2010	Ganglioside GM1, known as a glycosphingolipid-enriched microdomain (GEM) marker, was found to be up-regulated in B3gnt5(-/-) B cells by flow cytometry and fluorescence microscopy.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-15
20427129-10	2010	The findings indicate that as yet unidentified ganglioside(s) synthesized by the glucosylceramide synthase pathway may be essential for nociception through mechanisms which may implicate membrane lipid raft function and/or altered nerve growth factor signaling, which are essential for the TRPV1 receptor function.	Gangliosides	47-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	290-295
20547865-5	2010	Ganglioside GM1, known as a glycosphingolipid-enriched microdomain (GEM) marker, was found to be up-regulated in B3gnt5(-/-) B cells by flow cytometry and fluorescence microscopy.	Gangliosides	0-11	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5	Mus musculus	113-126
20226163-1	2010	Ganglioside GM1 mediates the amyloid beta (Abeta) aggregation that is the hallmark of Alzheimer"s disease (AD).	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	29-41
20525256-9	2010	NP-C is currently described as a cellular cholesterol trafficking defect but in the brain, the prominently stored lipids are gangliosides.	Gangliosides	125-137	NPC intracellular cholesterol transporter 1	Homo sapiens	0-4
20156584-7	2010	In contrast, the tyrosine phosphorylation of ErbB2 in ganglioside-depleted cells occurred only after EGF stimulation.	Gangliosides	54-65	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-50
20156584-0	2010	Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation.	Gangliosides	0-12	epidermal growth factor receptor	Homo sapiens	23-27
20156584-0	2010	Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation.	Gangliosides	0-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-33
20156584-7	2010	In contrast, the tyrosine phosphorylation of ErbB2 in ganglioside-depleted cells occurred only after EGF stimulation.	Gangliosides	54-65	epidermal growth factor	Homo sapiens	101-104
20226163-1	2010	Ganglioside GM1 mediates the amyloid beta (Abeta) aggregation that is the hallmark of Alzheimer"s disease (AD).	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	43-48
20156584-0	2010	Gangliosides influence EGFR/ErbB2 heterodimer stability but they do not modify EGF-dependent ErbB2 phosphorylation.	Gangliosides	0-12	epidermal growth factor	Homo sapiens	23-26
20226163-2	2010	To investigate how ganglioside-containing lipid bilayers interact with Abeta, we examined the interaction between Abeta40 and supported planar lipid bilayers (SPBs) on mica and SiO(2) substrates by using atomic force microscopy, fluorescence microscopy, and molecular dynamics computer simulations.	Gangliosides	19-30	amyloid beta precursor protein	Homo sapiens	71-76
20156584-2	2010	Previously, our group provided the first evidence about stable association of ganglioside GM(3) to EGFR/ErbB2 heterodimers in mammary epithelial cells.	Gangliosides	78-89	epidermal growth factor receptor	Homo sapiens	99-103
20156584-2	2010	Previously, our group provided the first evidence about stable association of ganglioside GM(3) to EGFR/ErbB2 heterodimers in mammary epithelial cells.	Gangliosides	78-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-109
20156584-8	2010	Moreover, when ganglioside-depleted cells were treated with DIP in absence of EGF, beta-casein gene expression appeared strongly down-regulated, and beta-casein mRNA levels were partially restored by exogenous GM(3) treatment.	Gangliosides	15-26	casein beta	Homo sapiens	83-94
20156584-8	2010	Moreover, when ganglioside-depleted cells were treated with DIP in absence of EGF, beta-casein gene expression appeared strongly down-regulated, and beta-casein mRNA levels were partially restored by exogenous GM(3) treatment.	Gangliosides	15-26	casein beta	Homo sapiens	149-160
20156584-3	2010	Goals of the present study were to better define the role of gangliosides in EGFR/ErbB2 heterodimerization and receptor phosphorylation events and to analyze their involvement in mammary cell differentiation.	Gangliosides	61-73	epidermal growth factor receptor	Homo sapiens	77-81
20156584-3	2010	Goals of the present study were to better define the role of gangliosides in EGFR/ErbB2 heterodimerization and receptor phosphorylation events and to analyze their involvement in mammary cell differentiation.	Gangliosides	61-73	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-87
20156584-6	2010	Results from co-immunoprecipitation and Western blot experiments have shown that the endogenous ganglioside depletion resulted in the disappearance of SDS-stable EGFR/ErbB2 heterodimers and in the appearance of tyrosine-phosphorylated EGFR also in the absence of EGF stimulation; exogenous GM(3) added in combination with [D]-PDMP reversed both these effects.	Gangliosides	96-107	epidermal growth factor receptor	Homo sapiens	162-166
20156584-6	2010	Results from co-immunoprecipitation and Western blot experiments have shown that the endogenous ganglioside depletion resulted in the disappearance of SDS-stable EGFR/ErbB2 heterodimers and in the appearance of tyrosine-phosphorylated EGFR also in the absence of EGF stimulation; exogenous GM(3) added in combination with [D]-PDMP reversed both these effects.	Gangliosides	96-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	167-172
20156584-6	2010	Results from co-immunoprecipitation and Western blot experiments have shown that the endogenous ganglioside depletion resulted in the disappearance of SDS-stable EGFR/ErbB2 heterodimers and in the appearance of tyrosine-phosphorylated EGFR also in the absence of EGF stimulation; exogenous GM(3) added in combination with [D]-PDMP reversed both these effects.	Gangliosides	96-107	epidermal growth factor receptor	Homo sapiens	235-239
20156584-6	2010	Results from co-immunoprecipitation and Western blot experiments have shown that the endogenous ganglioside depletion resulted in the disappearance of SDS-stable EGFR/ErbB2 heterodimers and in the appearance of tyrosine-phosphorylated EGFR also in the absence of EGF stimulation; exogenous GM(3) added in combination with [D]-PDMP reversed both these effects.	Gangliosides	96-107	epidermal growth factor	Homo sapiens	162-165
20156584-10	2010	Moreover, modulation of EGFR phosphorylation may explain how gangliosides contribute to regulate the lactogenic hormone-induced mammary cell differentiation.	Gangliosides	61-73	epidermal growth factor receptor	Homo sapiens	24-28
21394236-4	2010	For example, the small molecule inhibition of glucosylceramide synthase by miglustat limits ganglioside accumulation and is now the only approved treatment of Niemann-Pick type C. In addition, 2-hydroxypropyl-B-cyclodextrin, a lipid chelator, relieves the lysosomal to endoplasmic reticulum blockage and markedly increases the life expectancy of the murine model.	Gangliosides	92-103	UDP-glucose ceramide glucosyltransferase	Mus musculus	46-71
19490186-5	2010	Flow cytometry using the intracellular ROS-sensitive fluorescence dichlorodihydrofluorescein diacetate dye employed to investigate the transport of the extracellularly supplied H(2)O(2) into the cell interior revealed that ganglioside GT1b completely inhibited the passage of H(2)O(2) through the sperm membrane.	Gangliosides	223-234	beta-1,4-galactosyltransferase 1	Homo sapiens	235-238
20392887-0	2010	Binding to gangliosides containing N-acetylneuraminic acid is sufficient to mediate the immunomodulatory properties of the nontoxic mucosal adjuvant LT-IIb(T13I).	Gangliosides	11-23	ATPase, class II, type 9B	Mus musculus	152-155
19726412-1	2010	BACKGROUND: Reactivity against terminal NeuNAc(alpha2-3)Gal, common to several gangliosides such as GD1a, GT1b and GM3, has rarely been reported.	Gangliosides	79-91	immunoglobulin kappa variable 2-24	Homo sapiens	40-55
19726412-7	2010	RESULTS: Reactivity against NeuNAc(alpha2-3)Gal, shared by GM3, GD1a and GT1b gangliosides, was detected in 10 patients: isolated in one patient, and concomitant with reactivity against other gangliosides in the remaining patients.	Gangliosides	78-90	immunoglobulin kappa variable 2-24	Homo sapiens	28-43
19726412-7	2010	RESULTS: Reactivity against NeuNAc(alpha2-3)Gal, shared by GM3, GD1a and GT1b gangliosides, was detected in 10 patients: isolated in one patient, and concomitant with reactivity against other gangliosides in the remaining patients.	Gangliosides	192-204	immunoglobulin kappa variable 2-24	Homo sapiens	28-43
20077429-5	2010	The animals developed anti-GD3 ganglioside antibodies and manifested neuromuscular dysfunction.	Gangliosides	31-42	GRDX	Homo sapiens	27-30
20181697-4	2010	These data provide evidence that Abl family kinases reduce ganglioside turnover in the plasma membrane by inhibiting host cell sialidase activity.	Gangliosides	59-70	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	33-36
19822143-2	2010	By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains and propose the new therapeutic strategy "membrane microdomain ortho-signaling therapy".	Gangliosides	179-191	insulin	Homo sapiens	103-110
19822144-3	2010	Brain gangliosides function, in part, by interacting with a ganglioside-binding lectin, myelin-associated glycoprotein (MAG).	Gangliosides	6-18	myelin associated glycoprotein	Homo sapiens	88-118
19822144-3	2010	Brain gangliosides function, in part, by interacting with a ganglioside-binding lectin, myelin-associated glycoprotein (MAG).	Gangliosides	6-18	myelin associated glycoprotein	Homo sapiens	120-123
19822144-3	2010	Brain gangliosides function, in part, by interacting with a ganglioside-binding lectin, myelin-associated glycoprotein (MAG).	Gangliosides	6-17	myelin associated glycoprotein	Homo sapiens	88-118
19822144-3	2010	Brain gangliosides function, in part, by interacting with a ganglioside-binding lectin, myelin-associated glycoprotein (MAG).	Gangliosides	6-17	myelin associated glycoprotein	Homo sapiens	120-123
20167655-4	2010	METHODS AND RESULTS: A peptide comprising amino acids 3136 to 3155 of apoB-100 (p210) was fused to the B subunit of cholera toxin (CTB), which binds to a ganglioside on mucosal epithelia.	Gangliosides	154-165	apolipoprotein B	Mus musculus	70-78
20167655-4	2010	METHODS AND RESULTS: A peptide comprising amino acids 3136 to 3155 of apoB-100 (p210) was fused to the B subunit of cholera toxin (CTB), which binds to a ganglioside on mucosal epithelia.	Gangliosides	154-165	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	131-134
20181697-5	2010	Thus, Abl family kinases regulate the susceptibility of cells to polyomavirus infection by modulating gangliosides required for viral attachment.	Gangliosides	102-114	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	6-9
20436925-0	2010	Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism.	Gangliosides	82-93	myelin-associated glycoprotein	Mus musculus	0-30
20383336-0	2010	Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
20383336-0	2010	Ganglioside GM3 levels are altered in a mouse model of HIBM: GM3 as a cellular marker of the disease.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	61-64
20093028-0	2010	T cells from patients with Guillain-Barre syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1.	Gangliosides	112-123	interferon gamma	Homo sapiens	59-75
20093028-8	2010	There was significantly increased production of interferon-gamma but not interleukin-5 in response to stimulation with the ganglioside GM1.	Gangliosides	123-134	interferon gamma	Homo sapiens	48-64
20080203-3	2010	In this study, we characterized the binding of the purified recombinant syt II-LD to BoNT and revealed that the recombinant syt II-LD in vivo could provide protection against BoNT/B intoxication in mice models, and the neutralization effect could be improved by using gangliosides.	Gangliosides	268-280	synaptotagmin II	Mus musculus	72-78
20080203-3	2010	In this study, we characterized the binding of the purified recombinant syt II-LD to BoNT and revealed that the recombinant syt II-LD in vivo could provide protection against BoNT/B intoxication in mice models, and the neutralization effect could be improved by using gangliosides.	Gangliosides	268-280	synaptotagmin II	Mus musculus	124-130
20219474-9	2010	Furthermore, an extended solvent-exposed hydrophobic loop, located between the Syt binding site and the ganglioside binding cleft, may serve as a third membrane association and binding element to contribute to high-affinity binding to the neuronal membrane.	Gangliosides	104-115	synaptotagmin 1	Homo sapiens	79-82
20213245-13	2010	Neu4 sialidase activity in cell lysates from TQ-treated live THP-1 cells desialylates natural gangliosides and mucin substrates.	Gangliosides	94-106	neuraminidase 4	Homo sapiens	0-4
20213245-13	2010	Neu4 sialidase activity in cell lysates from TQ-treated live THP-1 cells desialylates natural gangliosides and mucin substrates.	Gangliosides	94-106	GLI family zinc finger 2	Homo sapiens	61-66
20371994-4	2010	Soluble Abeta with unordered structures specifically binds to raft-like membranes containing a ganglioside cluster, the formation of which is facilitated by cholesterol.	Gangliosides	95-106	amyloid beta precursor protein	Rattus norvegicus	8-13
20371994-10	2010	Furthermore, nordihydroguaiaretic acid was found to effectively inhibit the ganglioside-induced amyloidogenesis by preventing the binding of Abeta to the membrane.	Gangliosides	76-87	amyloid beta precursor protein	Rattus norvegicus	141-146
20114052-3	2010	Here we identified a ganglioside-binding domain in alpha-syn (fragment 34-50), which includes the mutation site 46 linked to a familial form of PD (E46K).	Gangliosides	21-32	synuclein alpha	Homo sapiens	51-60
20114052-5	2010	alpha-Syn GBD interacts with several glycosphingolipids but has a marked preference for GM3, a minor brain ganglioside whose expression increases with aging.	Gangliosides	107-118	synuclein alpha	Homo sapiens	0-9
20436925-0	2010	Myelin-associated glycoprotein (MAG) protects neurons from acute toxicity using a ganglioside-dependent mechanism.	Gangliosides	82-93	myelin-associated glycoprotein	Mus musculus	32-35
20436925-6	2010	Gangliosides (sialylated glycosphingolipids) are one functional class of axonal receptors for MAG.	Gangliosides	0-12	myelin-associated glycoprotein	Mus musculus	94-97
20436925-7	2010	In the current studies, a direct role for gangliosides in mediating the acute protective effects of MAG was established.	Gangliosides	42-54	myelin-associated glycoprotein	Mus musculus	100-103
20436925-11	2010	We conclude that MAG protects neurites from acute toxic insult via a ganglioside-mediated signaling pathway that involves activation of RhoA.	Gangliosides	69-80	myelin-associated glycoprotein	Mus musculus	17-20
20436925-11	2010	We conclude that MAG protects neurites from acute toxic insult via a ganglioside-mediated signaling pathway that involves activation of RhoA.	Gangliosides	69-80	ras homolog family member A	Mus musculus	136-140
20010096-7	2010	SUMMARY: In-vitro and animal studies show that n-3 PUFAs, cholesterol, and gangliosides modulate the structure and composition of lipid rafts, potentially influencing a wide range of biological processes, including immune function, neuronal signaling, cancer cell growth, entry of pathogens through the gut barrier, and insulin resistance in metabolic disorders.	Gangliosides	75-87	insulin	Homo sapiens	320-327
20118807-0	2010	Protection of intestinal occludin tight junction protein by dietary gangliosides in lipopolysaccharide-induced acute inflammation.	Gangliosides	68-80	occludin	Rattus norvegicus	25-33
20118807-3	2010	The purpose of this study was to determine whether dietary gangliosides (GGs) increase the concentration of the anti-inflammatory cytokine interleukin-10 (IL-10) in response to LPS, thereby inhibiting NO production and protecting gut occludin tight junction protein from degradation.	Gangliosides	59-71	interleukin 10	Rattus norvegicus	139-153
20118807-3	2010	The purpose of this study was to determine whether dietary gangliosides (GGs) increase the concentration of the anti-inflammatory cytokine interleukin-10 (IL-10) in response to LPS, thereby inhibiting NO production and protecting gut occludin tight junction protein from degradation.	Gangliosides	59-71	interleukin 10	Rattus norvegicus	155-160
20118807-3	2010	The purpose of this study was to determine whether dietary gangliosides (GGs) increase the concentration of the anti-inflammatory cytokine interleukin-10 (IL-10) in response to LPS, thereby inhibiting NO production and protecting gut occludin tight junction protein from degradation.	Gangliosides	59-71	occludin	Rattus norvegicus	234-242
20032467-10	2010	These analyses reveal novel ficolin ligands such as sulfated N-acetyllactosamine (L-ficolin) and gangliosides (M-ficolin) and provide precise insights into the sialic acid binding specificity of M-ficolin, emphasizing the essential role of Tyr(271) in this respect.	Gangliosides	97-109	ficolin 1	Homo sapiens	111-120
19896222-0	2010	BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide.	Gangliosides	33-44	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	0-4
20067473-6	2010	Incubation of the cells with a mixture of gangliosides increased a punctate distribution of fluorescently labelled microtubule-associated protein 1 light chain 3 (GFP-LC3), the ratio of LC3-II/LC3-I and LC3 flux.	Gangliosides	42-54	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	186-206
20067473-8	2010	Ganglioside-induced cell death was inhibited by either a knockdown of beclin-1/Atg-6 or Atg-7 gene expression or by 3-methyladenine, an inhibitor of autophagy.	Gangliosides	0-11	beclin 1	Homo sapiens	70-78
20067473-8	2010	Ganglioside-induced cell death was inhibited by either a knockdown of beclin-1/Atg-6 or Atg-7 gene expression or by 3-methyladenine, an inhibitor of autophagy.	Gangliosides	0-11	beclin 1	Homo sapiens	79-84
20067473-8	2010	Ganglioside-induced cell death was inhibited by either a knockdown of beclin-1/Atg-6 or Atg-7 gene expression or by 3-methyladenine, an inhibitor of autophagy.	Gangliosides	0-11	autophagy related 7	Homo sapiens	88-93
19610094-6	2010	Blockade of IL-15, both with blocking antibodies or with the ganglioside Neurostatin, inhibited the activation of the NFkappaB pathway, decreasing iNOS expression and NO production.	Gangliosides	61-72	interleukin 15	Homo sapiens	12-17
19610094-6	2010	Blockade of IL-15, both with blocking antibodies or with the ganglioside Neurostatin, inhibited the activation of the NFkappaB pathway, decreasing iNOS expression and NO production.	Gangliosides	61-72	nuclear factor kappa B subunit 1	Homo sapiens	118-126
19958765-8	2010	Inhibition of ganglioside biosynthesis by d-threo-1-Phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP, 10-20microM) or myriocyn (5-50nM) diminished similarly capsaicin- or RTX-evoked calcium uptake in both cultured trigeminal neurons and rTRPV1-expressing cells.	Gangliosides	14-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	243-249
19958765-10	2010	Evidence for a supporting role of cholesterol, sphingomyelin and gangliosides were obtained both in native and TRPV1-transfected cells.	Gangliosides	65-77	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	111-116
20074569-1	2010	Gangliosides are targets for a variety of pathologically relevant proteins, including amyloid beta (Abeta), an important component implicated in Alzheimer"s disease (AD).	Gangliosides	0-12	amyloid beta precursor protein	Homo sapiens	86-98
20074569-1	2010	Gangliosides are targets for a variety of pathologically relevant proteins, including amyloid beta (Abeta), an important component implicated in Alzheimer"s disease (AD).	Gangliosides	0-12	amyloid beta precursor protein	Homo sapiens	100-105
20074569-2	2010	To provide a structural basis for this pathogenic interaction associated with AD, we conducted NMR analyses of the Abeta interactions with gangliosides using lyso-GM1 micelles as a model system.	Gangliosides	139-151	amyloid beta precursor protein	Homo sapiens	115-120
20074569-3	2010	Our NMR data revealed that the sugar-lipid interface is primarily perturbed upon binding of Abeta to the micelles, underscoring the importance of the inner part of the ganglioside cluster for accommodating Abeta in comparison with the outer carbohydrate branches that provide microbial toxin- and virus-binding sites.	Gangliosides	168-179	amyloid beta precursor protein	Homo sapiens	92-97
20074569-3	2010	Our NMR data revealed that the sugar-lipid interface is primarily perturbed upon binding of Abeta to the micelles, underscoring the importance of the inner part of the ganglioside cluster for accommodating Abeta in comparison with the outer carbohydrate branches that provide microbial toxin- and virus-binding sites.	Gangliosides	168-179	amyloid beta precursor protein	Homo sapiens	206-211
20173038-4	2010	Co-stimulation of FcepsilonRI and CCR1 with antigen and macrophage inflammatory protein-1alpha was more effective than FcepsilonRI stimulation alone in causing leading edge formation, flattened morphology, membrane ruffles and ganglioside (GM1(+)) lipid mediator release.	Gangliosides	227-238	Fc epsilon receptor Ia	Homo sapiens	18-29
20173038-4	2010	Co-stimulation of FcepsilonRI and CCR1 with antigen and macrophage inflammatory protein-1alpha was more effective than FcepsilonRI stimulation alone in causing leading edge formation, flattened morphology, membrane ruffles and ganglioside (GM1(+)) lipid mediator release.	Gangliosides	227-238	C-C motif chemokine receptor 1	Homo sapiens	34-38
20173038-4	2010	Co-stimulation of FcepsilonRI and CCR1 with antigen and macrophage inflammatory protein-1alpha was more effective than FcepsilonRI stimulation alone in causing leading edge formation, flattened morphology, membrane ruffles and ganglioside (GM1(+)) lipid mediator release.	Gangliosides	227-238	C-C motif chemokine receptor 1	Homo sapiens	56-94
19896222-2	2010	B-cell activating factor belonging to the TNF family (BAFF) helped murine B cells produce anti-ganglioside antibodies against C. jejuni LOS.	Gangliosides	95-106	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	0-24
19896222-2	2010	B-cell activating factor belonging to the TNF family (BAFF) helped murine B cells produce anti-ganglioside antibodies against C. jejuni LOS.	Gangliosides	95-106	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	54-58
19896222-3	2010	In splenocyte culture, however, anti-ganglioside antibodies were produced in the presence of a soluble transmembrane activator and calcium-modulating and cyclophilin ligand interactor immunoadhesin (TACI-Ig), a receptor for BAFF.	Gangliosides	37-48	tumor necrosis factor (ligand) superfamily, member 13b	Mus musculus	224-228
19588508-1	2010	Membrane-linked sialidase Neu3 is a key enzyme for the extralysosomal catabolism of gangliosides.	Gangliosides	84-96	neuraminidase 3	Homo sapiens	26-30
19588508-3	2010	In this report, we demonstrated that acute lymphoblastic leukemia (ALL), lymphoblasts (primary cells from patients and cell lines) are characterized by a marked down-regulation of Neu3 in terms of both gene expression (-30 to 40%) and enzymatic activity toward ganglioside GD1a (-25.6 to 30.6%), when compared with cells from healthy controls.	Gangliosides	261-272	neuraminidase 3	Homo sapiens	180-184
19898953-1	2009	GM(2)-gangliosidosis is a rare and heterogeneous inherited metabolic disorder caused by autosomal recessive mutations in genes encoding the lysosomal enzyme beta-hexosaminidase, resulting in the accumulation of ganglioside GM(2) in various tissues, particularly the central nervous system.	Gangliosides	211-222	O-GlcNAcase	Homo sapiens	157-176
21137678-1	2010	The tetrasaccharide 4, a substructure of ganglioside GQ1balpha, shows a remarkable affinity for the myelin-associated glycoprotein (MAG) and was therefore selected as starting point for a lead optimization program.	Gangliosides	41-52	myelin associated glycoprotein	Homo sapiens	100-130
21137678-1	2010	The tetrasaccharide 4, a substructure of ganglioside GQ1balpha, shows a remarkable affinity for the myelin-associated glycoprotein (MAG) and was therefore selected as starting point for a lead optimization program.	Gangliosides	41-52	myelin associated glycoprotein	Homo sapiens	132-135
20919653-2	2010	Activation of glucosylceramide synthase, the enzyme that places a glucosyl moiety onto ceramide, is the first pathway-committed step to the production of more complex glycosphingolipids such as lactosylceramide and gangliosides.	Gangliosides	215-227	UDP-glucose ceramide glucosyltransferase	Homo sapiens	14-39
19759399-2	2010	Overexpression of GM3 synthase in A2780 cells consistently resulted in elevated ganglioside (GM3, GM2 and GD1a) levels.	Gangliosides	80-91	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	18-30
19759399-8	2010	In addition, the motility of low GM3 synthase expressing cells was also reduced in the presence of a Src kinase inhibitor; on the other hand, higher levels of the inactive form of c-Src were detected in GM3 synthase overexpressing cells, associated with a ganglioside- and caveolin-rich detergent insoluble fraction.	Gangliosides	256-267	Src oncogene at 64B	Drosophila melanogaster	180-185
19759399-8	2010	In addition, the motility of low GM3 synthase expressing cells was also reduced in the presence of a Src kinase inhibitor; on the other hand, higher levels of the inactive form of c-Src were detected in GM3 synthase overexpressing cells, associated with a ganglioside- and caveolin-rich detergent insoluble fraction.	Gangliosides	256-267	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	203-215
19797321-2	2010	An efficient separation and sensitive detection of Neu5Gc-containing gangliosides from Neu5Ac-containing analogues was for the first time accomplished in a single nanoHPLC/ESI-QTOF MS run, as demonstrated for mouse hybridoma cell GM3 fraction containing GM3(Neu5Ac) and GM3(Neu5Gc) species and further applied for the analysis of YAC-1 lymphoma cell monosialoganglioside fraction.	Gangliosides	69-81	ADP-ribosyltransferase 1	Mus musculus	330-335
20625494-0	2010	Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus patients.	Gangliosides	24-35	CD4 molecule	Homo sapiens	54-57
20625494-0	2010	Increased expression of ganglioside GM1 in peripheral CD4+ T cells correlates soluble form of CD30 in Systemic Lupus Erythematosus patients.	Gangliosides	24-35	TNF receptor superfamily member 8	Homo sapiens	94-98
19657748-5	2010	The binding activity of LTB protein expressed in transgenic rice callus to G(M1)-ganglioside, a receptor for biologically active LTB, was confirmed by G(M1)-ELISA.	Gangliosides	81-92	lymphotoxin B	Mus musculus	24-27
19657748-5	2010	The binding activity of LTB protein expressed in transgenic rice callus to G(M1)-ganglioside, a receptor for biologically active LTB, was confirmed by G(M1)-ELISA.	Gangliosides	81-92	lymphotoxin B	Mus musculus	129-132
19745600-4	2009	HPTLC/immunofluorescence analyses of shRNA- transfected mESCs revealed that treatment with Ugcg-shRNA decreased expression of major gangliosides, GM3 and GD3.	Gangliosides	132-144	UDP-glucose ceramide glucosyltransferase	Mus musculus	91-95
19745762-9	2009	RESULTS: Ganglioside preexposure reduced bowel necrosis and endothelin-1 production in response to LPS.	Gangliosides	9-20	endothelin 1	Homo sapiens	60-72
19956670-3	2009	In particular, ganglioside GD3 has been characterized as a proapoptotic lipid effector by promoting cell death signaling and suppression of survival pathways.	Gangliosides	15-26	GRDX	Homo sapiens	27-30
19632205-6	2009	The ganglioside requirement for mielossuportive function was confirmed by the decreased proliferation of FDC-P1 cells in ganglioside synthesis-inhibited cultures and in presence of an antibody to GM3 ganglioside.	Gangliosides	4-15	granulocyte macrophage antigen 3	Mus musculus	196-199
19632200-8	2009	We found that 30-40% of the both forms of Neu2 activity was located in the crude membrane-fraction, and hydrolyzed ganglioside effectively, while both soluble fraction showed particular behavior with substrate specificity.	Gangliosides	115-126	neuraminidase 2	Mus musculus	42-46
19608407-3	2009	Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein), and inflammation via E-selectin.	Gangliosides	84-96	sialic acid binding Ig like lectin 7	Homo sapiens	193-201
19608407-3	2009	Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein), and inflammation via E-selectin.	Gangliosides	84-96	myelin associated glycoprotein	Homo sapiens	242-272
19608407-3	2009	Through sugar-specific interactions with glycan-binding proteins on apposing cells, gangliosides function as receptors in cell-cell recognition, regulating natural killer cell cytotoxicity via Siglec-7, myelin-axon interactions via Siglec-4 (myelin-associated glycoprotein), and inflammation via E-selectin.	Gangliosides	84-96	selectin E	Homo sapiens	296-306
19608407-4	2009	Gangliosides also interact laterally in their own membranes, regulating the responsiveness of signaling proteins including the insulin, epidermal growth factor, and vascular endothelial growth factor receptors.	Gangliosides	0-12	insulin	Homo sapiens	127-134
19608407-4	2009	Gangliosides also interact laterally in their own membranes, regulating the responsiveness of signaling proteins including the insulin, epidermal growth factor, and vascular endothelial growth factor receptors.	Gangliosides	0-12	epidermal growth factor	Homo sapiens	136-159
19658121-2	2009	The method was optimized and tested on a polysialylated ganglioside fraction (GT1b), which was profiled by MS1 and sequenced in tandem MS up to MS6 in the same experiment.	Gangliosides	56-67	MS	Homo sapiens	107-110
19686243-2	2009	GM1, one of the major gangliosides of this membrane, was shown to be tightly associated with a sodium-calcium exchanger in the inner membrane of the NE and to potentiate exchanger activity.	Gangliosides	22-34	coenzyme Q10A	Mus musculus	0-3
19602728-7	2009	Using these gangliosides and mutated forms of HCR/T that lacked one or both carbohydrate-binding pocket, gangliosides binding to both of the W and R pockets were shown to be necessary for high affinity binding to neuronal and non-neuronal cells.	Gangliosides	105-117	C-C motif chemokine receptor like 2	Homo sapiens	46-49
19602728-8	2009	The crystal structure of a ternary complex of HCR/T with sugar components of two gangliosides bound to the W and R supported the binding of gangliosides to both carbohydrate pockets.	Gangliosides	81-93	C-C motif chemokine receptor like 2	Homo sapiens	46-49
19602728-8	2009	The crystal structure of a ternary complex of HCR/T with sugar components of two gangliosides bound to the W and R supported the binding of gangliosides to both carbohydrate pockets.	Gangliosides	140-152	C-C motif chemokine receptor like 2	Homo sapiens	46-49
19580786-6	2009	To confirm the role of gangliosides in neural differentiation, ganglioside biosynthesis was inhibited in hDPSCs by knockdown of UDP-glucose ceramide glucosyltransferase (Ugcg), which prevented differentiation into neural cells.	Gangliosides	23-35	UDP-glucose ceramide glucosyltransferase	Homo sapiens	170-174
19647738-3	2009	In this study, we demonstrate that gangliosides play an essential role in the formation of amyloid deposits by hIAPP on plasma membranes.	Gangliosides	35-47	islet amyloid polypeptide	Homo sapiens	111-116
19052862-2	2009	To characterize the conformation of Abeta bound to the ganglioside, we performed 920 MHz ultra-high field NMR analyses using isotopically labeled Abeta(1-40) in association with GM1 and lyso-GM1 micelles.	Gangliosides	55-66	amyloid beta precursor protein	Homo sapiens	36-41
19052862-2	2009	To characterize the conformation of Abeta bound to the ganglioside, we performed 920 MHz ultra-high field NMR analyses using isotopically labeled Abeta(1-40) in association with GM1 and lyso-GM1 micelles.	Gangliosides	55-66	amyloid beta precursor protein	Homo sapiens	146-151
19052862-4	2009	These findings suggest that the ganglioside clusters serve as a unique platform for binding coupled with conformational transition of Abeta molecules, rendering their spatial rearrangements restricted to promote specific intermolecular interactions.	Gangliosides	32-43	amyloid beta precursor protein	Homo sapiens	134-139
19765188-1	2009	Sandhoff disease is a progressive neurodegenerative disorder caused by mutations in the HEXB gene which encodes the beta-subunit of N-acetyl-beta-hexosaminidase A and B, resulting in the accumulation of the ganglioside GM2.	Gangliosides	207-218	hexosaminidase B	Mus musculus	88-92
19780154-1	2009	Sandhoff"s disease is a lysosomal storage disease in which the ganglioside GM2 accumulates in lysosomes.	Gangliosides	63-74	cytochrome b5 domain containing 2	Mus musculus	75-78
18258340-1	2009	Gangliosides have been shown to be necessary for beta-amyloid (Abeta) binding and aggregation.	Gangliosides	0-12	amyloid beta (A4) precursor protein	Mus musculus	63-68
18258340-2	2009	GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides.	Gangliosides	75-87	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	0-12
18258340-2	2009	GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides.	Gangliosides	75-87	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	14-18
18258340-2	2009	GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides.	Gangliosides	127-139	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	0-12
18258340-2	2009	GD3 synthase (GD3S) is responsible for biosynthesis of the b- and c-series gangliosides, including two of the four major brain gangliosides.	Gangliosides	127-139	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	14-18
19720032-1	2009	The GM2 activator protein (GM2AP) is an accessory protein that is an essential component in the catabolism of the ganglioside GM2.	Gangliosides	114-125	ganglioside GM2 activator	Homo sapiens	4-25
19720032-1	2009	The GM2 activator protein (GM2AP) is an accessory protein that is an essential component in the catabolism of the ganglioside GM2.	Gangliosides	114-125	ganglioside GM2 activator	Homo sapiens	27-32
19745762-10	2009	Gangliosides suppressed infant bowel production of nitric oxide, leukotriene B4, prostaglandin E2, hydrogen peroxide, interleukin-1beta, interleukin-6, and interleukin-8 in response to LPS exposure and hypoxia.	Gangliosides	0-12	interleukin 1 beta	Homo sapiens	118-135
19745762-10	2009	Gangliosides suppressed infant bowel production of nitric oxide, leukotriene B4, prostaglandin E2, hydrogen peroxide, interleukin-1beta, interleukin-6, and interleukin-8 in response to LPS exposure and hypoxia.	Gangliosides	0-12	interleukin 6	Homo sapiens	137-150
19745762-10	2009	Gangliosides suppressed infant bowel production of nitric oxide, leukotriene B4, prostaglandin E2, hydrogen peroxide, interleukin-1beta, interleukin-6, and interleukin-8 in response to LPS exposure and hypoxia.	Gangliosides	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	156-169
19506080-6	2009	Distinct from the human isoforms, the murine forms, to a different extent, both catalyzed the removal of sialic acid from gangliosides as well as glycoproteins, and one isoform seemed to act on polysialylated NCAM efficiently, despite the low activity toward ordinary substrates.	Gangliosides	122-134	neural cell adhesion molecule 1	Mus musculus	209-213
19438805-1	2009	Ganglioside GM1-bound cholera toxin-B sub-unit (CT-b) enters the cell via clathrin-coated pits and dynamin-independent non-caveolar raft-dependent endocytosis.	Gangliosides	0-11	phosphate cytidylyltransferase 1B, choline	Homo sapiens	22-46
19438805-1	2009	Ganglioside GM1-bound cholera toxin-B sub-unit (CT-b) enters the cell via clathrin-coated pits and dynamin-independent non-caveolar raft-dependent endocytosis.	Gangliosides	0-11	phosphate cytidylyltransferase 1B, choline	Homo sapiens	48-52
19886192-6	2009	Thus, the ganglioside GM1 antioxidant effect on PC12 is mediated by activation of tyrosine kinase Trk-receptors and protein kinases perceiving signal from this enzyme.	Gangliosides	10-21	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	98-101
19559406-12	2009	The correlation between high motility and high level of EGFR with the ganglioside-TSP complex in A431 cells is unique.	Gangliosides	70-81	epidermal growth factor receptor	Homo sapiens	56-60
19560125-0	2009	Study on systematizing the synthesis of the a-series ganglioside glycans GT1a, GD1a, and GM1 using the newly developed N-Troc-protected GM3 and GalN intermediates.	Gangliosides	53-64	galanin and GMAP prepropeptide	Homo sapiens	144-148
19563785-2	2009	IGF-1:TTC exhibited IGF-1 and TTC activity in vitro; it increased levels of immunoreactive phosphoAkt in treated MCF-7 cells and bound to immobilized ganglioside GT1b.	Gangliosides	150-161	insulin like growth factor 1	Homo sapiens	0-5
19559406-2	2009	Ganglioside GM3 was previously found to interact with EGFR and to inhibit EGFR tyrosine kinase.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	54-58
19559406-2	2009	Ganglioside GM3 was previously found to interact with EGFR and to inhibit EGFR tyrosine kinase.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	74-78
19216024-0	2009	The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif.	Gangliosides	90-101	prominin 1	Homo sapiens	62-67
19653909-5	2009	We found the short-term (<24 h) activation of IL-6 involved the coordinate up-regulation of toll-like receptor-4 (TLR4) with complementary changes to NEU3 and ST3GAL5 that reduced ganglioside GM3 in a manner that augmented the activation of TLR4 and IL-6.	Gangliosides	183-194	interleukin 6	Homo sapiens	49-53
19653909-5	2009	We found the short-term (<24 h) activation of IL-6 involved the coordinate up-regulation of toll-like receptor-4 (TLR4) with complementary changes to NEU3 and ST3GAL5 that reduced ganglioside GM3 in a manner that augmented the activation of TLR4 and IL-6.	Gangliosides	183-194	toll like receptor 4	Homo sapiens	117-121
19653909-5	2009	We found the short-term (<24 h) activation of IL-6 involved the coordinate up-regulation of toll-like receptor-4 (TLR4) with complementary changes to NEU3 and ST3GAL5 that reduced ganglioside GM3 in a manner that augmented the activation of TLR4 and IL-6.	Gangliosides	183-194	neuraminidase 3	Homo sapiens	153-157
19653909-5	2009	We found the short-term (<24 h) activation of IL-6 involved the coordinate up-regulation of toll-like receptor-4 (TLR4) with complementary changes to NEU3 and ST3GAL5 that reduced ganglioside GM3 in a manner that augmented the activation of TLR4 and IL-6.	Gangliosides	183-194	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	162-169
19406831-0	2009	Functional implication of BAFF synthesis and release in gangliosides-stimulated microglia.	Gangliosides	56-68	TNF superfamily member 13b	Rattus norvegicus	26-30
19406831-2	2009	In the present study, we examined whether BAFF is expressed in microglia, and the expression and release of BAFF are regulated by gangliosides.	Gangliosides	130-142	TNF superfamily member 13b	Rattus norvegicus	108-112
19406831-4	2009	Furthermore, its expression and release were increased by gangliosides stimulation and regulated by JAK-STAT, especially the STAT1- and STAT3-dependent signaling pathways.	Gangliosides	58-70	signal transducer and activator of transcription 1	Rattus norvegicus	125-130
19406831-4	2009	Furthermore, its expression and release were increased by gangliosides stimulation and regulated by JAK-STAT, especially the STAT1- and STAT3-dependent signaling pathways.	Gangliosides	58-70	signal transducer and activator of transcription 3	Rattus norvegicus	136-141
19630917-5	2009	Furthermore, the suggested binding mode, where the hydrophobic tail groups of lipids locate inside Bet v 1, while the polar head group may remain solvent accessible, would allow Bet v 1 to bind glycolipids, e.g. gangliosides, also rich on caveolae/lipid rafts.	Gangliosides	212-224	delta/notch like EGF repeat containing	Homo sapiens	99-102
19630917-5	2009	Furthermore, the suggested binding mode, where the hydrophobic tail groups of lipids locate inside Bet v 1, while the polar head group may remain solvent accessible, would allow Bet v 1 to bind glycolipids, e.g. gangliosides, also rich on caveolae/lipid rafts.	Gangliosides	212-224	delta/notch like EGF repeat containing	Homo sapiens	178-181
19423750-0	2009	Uptake and fate of ganglioside GD3 in human intestinal Caco-2 cells.	Gangliosides	19-30	GRDX	Homo sapiens	31-34
19423750-1	2009	Ganglioside GD3 is a glycosphingolipid found in colostrum, developing tissues, and tumors and is known to regulate cell growth, differentiation, apoptosis, and inflammation.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
19423750-9	2009	This study demonstrates efficient GD3 uptake by enterocytes and suggests that the route of delivery influences ganglioside uptake and fate.	Gangliosides	111-122	GRDX	Homo sapiens	34-37
19476346-9	2009	The interaction of HCR/F with gangliosides was also investigated.	Gangliosides	30-42	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	19-22
19476346-10	2009	HCR/F bound specifically to gangliosides that contain alpha2,3-linked sialic acid on the terminal galactose of a neutral saccharide core (binding order GT1b = GD1a >> GM3; no binding to GD1b and GM1a).	Gangliosides	28-40	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	0-3
19476346-11	2009	Mutations within the putative ganglioside binding pocket of HCR/F decreased binding to gangliosides, synaptic vesicle protein complexes, and primary rat hippocampal neurons.	Gangliosides	30-41	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	60-63
19476346-11	2009	Mutations within the putative ganglioside binding pocket of HCR/F decreased binding to gangliosides, synaptic vesicle protein complexes, and primary rat hippocampal neurons.	Gangliosides	87-99	coiled-coil alpha-helical rod protein 1	Rattus norvegicus	60-63
19406831-5	2009	It was of particular interest to observe that SP600125 and SB203580, specific inhibitors of JNK and p38, did not inhibit BAFF synthesis but inhibited the release of sBAFF in gangliosides-treated cells by regulating furin expression, suggesting that the JNK and p38 signaling pathways regulate the release but not the synthesis of BAFF.	Gangliosides	174-186	mitogen activated protein kinase 14	Rattus norvegicus	100-103
19406831-5	2009	It was of particular interest to observe that SP600125 and SB203580, specific inhibitors of JNK and p38, did not inhibit BAFF synthesis but inhibited the release of sBAFF in gangliosides-treated cells by regulating furin expression, suggesting that the JNK and p38 signaling pathways regulate the release but not the synthesis of BAFF.	Gangliosides	174-186	furin (paired basic amino acid cleaving enzyme)	Rattus norvegicus	215-220
19406831-5	2009	It was of particular interest to observe that SP600125 and SB203580, specific inhibitors of JNK and p38, did not inhibit BAFF synthesis but inhibited the release of sBAFF in gangliosides-treated cells by regulating furin expression, suggesting that the JNK and p38 signaling pathways regulate the release but not the synthesis of BAFF.	Gangliosides	174-186	mitogen activated protein kinase 14	Rattus norvegicus	261-264
19406831-5	2009	It was of particular interest to observe that SP600125 and SB203580, specific inhibitors of JNK and p38, did not inhibit BAFF synthesis but inhibited the release of sBAFF in gangliosides-treated cells by regulating furin expression, suggesting that the JNK and p38 signaling pathways regulate the release but not the synthesis of BAFF.	Gangliosides	174-186	TNF superfamily member 13b	Rattus norvegicus	166-170
19537799-1	2009	The ganglioside GM1 has neuroprotective effects but is not of therapeutic value because of its lack of bioavailability.	Gangliosides	4-15	coenzyme Q10A	Mus musculus	16-19
19361287-2	2009	A highly efficient separation of alpha2-3- and alpha2-6-sialylated ganglioside species of different carbohydrate chain length was achieved on an HILIC-amido column, followed by sensitive flow-through ESI-QTOF-MS detection and unambiguous structural identification by tandem MS experiments.	Gangliosides	67-78	immunoglobulin binding protein 1	Homo sapiens	47-55
19538930-4	2009	Complexes formed by association of these Th2 cell-type cytokine-biasing alphaGalCer analogs with CD1d showed a distinctive exclusion from ganglioside-enriched, detergent-resistant plasma membrane microdomains of antigen-presenting cells.	Gangliosides	138-149	CD1d molecule	Homo sapiens	97-101
19216024-2	2009	We have generated anti-peptide antibodies against a N-terminal epitope of CD133 belonging to a ganglioside-binding domain.	Gangliosides	95-106	prominin 1	Homo sapiens	74-79
19216024-4	2009	CD133 immunolabelling progressively decreased to undetectable levels in post-confluent cultures, possibly through ganglioside-mediated epitope masking since the staining was partially recovered after chemical disruption of lipid rafts.	Gangliosides	114-125	prominin 1	Homo sapiens	0-5
19216024-5	2009	We suggest that selected gangliosides could modulate the accessibility of CD133 and regulate cell-cell contacts involving CD133(+) stem cells at the earliest steps of tumour development.	Gangliosides	25-37	prominin 1	Homo sapiens	74-79
19216024-5	2009	We suggest that selected gangliosides could modulate the accessibility of CD133 and regulate cell-cell contacts involving CD133(+) stem cells at the earliest steps of tumour development.	Gangliosides	25-37	prominin 1	Homo sapiens	122-127
19641732-3	2009	We have previously used fluorescence lifetime imaging microscopy to study the colocalization of the receptor for EGF with the ganglioside GM1 and the GPI-anchored green fluorescent protein.	Gangliosides	126-137	epidermal growth factor	Homo sapiens	113-116
19318031-4	2009	Beta-1,4-N-acetyl-galactosaminyl transferase 1 is the enzyme involved in the synthesis of asialo, a, b and c-series gangliosides and it is coded by B4GALNT1 gene.	Gangliosides	116-128	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	0-46
19318031-4	2009	Beta-1,4-N-acetyl-galactosaminyl transferase 1 is the enzyme involved in the synthesis of asialo, a, b and c-series gangliosides and it is coded by B4GALNT1 gene.	Gangliosides	116-128	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	148-156
19217912-3	2009	More specifically, it is thought that A beta interacts with ganglioside rich and sialic acid rich regions of cell surfaces.	Gangliosides	60-71	amyloid beta precursor protein	Homo sapiens	38-44
19470479-1	2009	The ganglioside GM3 synthase (SAT-I), encoded by a single-copy gene, is a primary glycosyltransferase for the synthesis of complex gangliosides.	Gangliosides	131-143	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	4-28
19002580-4	2009	The concentration of the neuronal enriched ganglioside GD1a was significantly lower in the cerebrum/brainstem of Mecp2 (tm1.1Bird) mice than in that of age matched controls, but was not reduced in the Mecp2 (308/y) mice.	Gangliosides	43-54	methyl CpG binding protein 2	Mus musculus	113-118
19002580-4	2009	The concentration of the neuronal enriched ganglioside GD1a was significantly lower in the cerebrum/brainstem of Mecp2 (tm1.1Bird) mice than in that of age matched controls, but was not reduced in the Mecp2 (308/y) mice.	Gangliosides	43-54	methyl CpG binding protein 2	Mus musculus	201-206
19215228-1	2009	Human plasma membrane-associated sialidase (NEU3) specifically hydrolyzes gangliosides, and it is up-regulated in colon cancer and plays an essential role in the expression of malignant phenotypes.	Gangliosides	74-86	neuraminidase 3	Mus musculus	13-48
19303901-4	2009	More complex glycosphingolipids, so-called gangliosides, block phosphorylation of the insulin receptor and down-stream signaling, possibly by exclusion of the insulin receptor from specific membrane domains.	Gangliosides	43-55	insulin receptor	Homo sapiens	86-102
19303901-4	2009	More complex glycosphingolipids, so-called gangliosides, block phosphorylation of the insulin receptor and down-stream signaling, possibly by exclusion of the insulin receptor from specific membrane domains.	Gangliosides	43-55	insulin receptor	Homo sapiens	159-175
19345758-7	2009	Mass spectrometry image analyses of the mouse brain tissue sections demonstrated that the N-fatty acyl chains of gangliosides were differentially distributed in mouse hippocampal regions, whereby the gangliosides with N-C(18) acyl chain were enriched in CA1 region, while gangliosides with N-C(20) acyl chain were enriched in dentate gyrus.	Gangliosides	113-125	carbonic anhydrase 1	Mus musculus	254-257
19345758-7	2009	Mass spectrometry image analyses of the mouse brain tissue sections demonstrated that the N-fatty acyl chains of gangliosides were differentially distributed in mouse hippocampal regions, whereby the gangliosides with N-C(18) acyl chain were enriched in CA1 region, while gangliosides with N-C(20) acyl chain were enriched in dentate gyrus.	Gangliosides	200-212	carbonic anhydrase 1	Mus musculus	254-257
19345758-7	2009	Mass spectrometry image analyses of the mouse brain tissue sections demonstrated that the N-fatty acyl chains of gangliosides were differentially distributed in mouse hippocampal regions, whereby the gangliosides with N-C(18) acyl chain were enriched in CA1 region, while gangliosides with N-C(20) acyl chain were enriched in dentate gyrus.	Gangliosides	200-212	carbonic anhydrase 1	Mus musculus	254-257
19276353-4	2009	Ganglioside-induced T-cell killing was associated with the caspase-dependent degradation of nuclear factor-kappaB-inducible, antiapoptotic proteins, including RelA; this suggests that their loss is initiated only after the cascade is activated and that their disappearance amplifies but not triggers GD3 susceptibility.	Gangliosides	0-11	RELA proto-oncogene, NF-kB subunit	Homo sapiens	159-163
19276353-4	2009	Ganglioside-induced T-cell killing was associated with the caspase-dependent degradation of nuclear factor-kappaB-inducible, antiapoptotic proteins, including RelA; this suggests that their loss is initiated only after the cascade is activated and that their disappearance amplifies but not triggers GD3 susceptibility.	Gangliosides	0-11	GRDX	Homo sapiens	300-303
18751977-2	2009	We have recently reported that MHC class I antigen processing machinery (APM) component expression in human DCs is down-regulated by tumor-derived gangliosides.	Gangliosides	147-159	MHC class I antigen	Homo sapiens	31-50
19187445-7	2009	Lipid analysis showed that SM and the gangliosides GM3 and GM2 accumulated in the brains of ASMKO mice, as opposed to galactocerebroside and galactosulfocerebroside that, in parallel with the mRNAs of UDP-galactose ceramide galactosyltransferase and galactose-3-O-sulfotransferase 1, the two transferases involved in their synthesis, decreased.	Gangliosides	38-50	granulocyte macrophage antigen 3	Mus musculus	51-54
18642128-3	2009	In this study, we have molecularly cloned from zebrafish sources, the orthologues of the six human alpha2,8-sialyltransferases (ST8Sia), a family of sialyltransferases implicated in the alpha2-8-mono-, oligo-, and poly-sialylation of glycoproteins and gangliosides and we have analysed their expression pattern in the embryonic zebrafish nervous system, using in situ hybridization.	Gangliosides	252-264	immunoglobulin binding protein 1	Homo sapiens	186-194
19276353-6	2009	RelA overexpression endows Jurkat cells with resistance to GD3-mediated apoptosis, verifying the role of the intact transcription factor in mediating protection from the ganglioside.	Gangliosides	170-181	RELA proto-oncogene, NF-kB subunit	Homo sapiens	0-4
19138679-4	2009	The ganglioside GM1 potentiated the effect of Abeta (1-40), as viewed from (31)P NMR.	Gangliosides	4-15	amyloid beta precursor protein	Homo sapiens	46-51
19124464-2	2009	Ganglioside GM3 containing sialyllactose inhibits the tyrosine kinase activity of EGFR through carbohydrate to carbohydrate interactions (CCI) between N-glycans with GlcNAc termini on EGFR and oligosaccharides on GM3.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	82-86
19124464-2	2009	Ganglioside GM3 containing sialyllactose inhibits the tyrosine kinase activity of EGFR through carbohydrate to carbohydrate interactions (CCI) between N-glycans with GlcNAc termini on EGFR and oligosaccharides on GM3.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	184-188
18681838-1	2009	BACKGROUND INFORMATION: Within the group of lysosomal storage diseases, NPC1 [NPC (Niemann-Pick type C) 1] disease is a lipidosis characterized by excessive accumulation of free cholesterol as well as gangliosides, glycosphingolipids and fatty acids in the late E/L (endosomal/lysosomal) system (Chen et al., 2005) due to a defect in late endosome lipid egress.	Gangliosides	201-213	NPC intracellular cholesterol transporter 1	Homo sapiens	72-76
18974200-0	2009	Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
18974200-0	2009	Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.	Gangliosides	0-11	vascular endothelial growth factor A	Mus musculus	25-29
18974200-0	2009	Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.	Gangliosides	0-11	kinase insert domain protein receptor	Mus musculus	30-37
18974200-0	2009	Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	83-86
18974200-0	2009	Ganglioside GM3 inhibits VEGF/VEGFR-2-mediated angiogenesis: direct interaction of GM3 with VEGFR-2.	Gangliosides	0-11	kinase insert domain protein receptor	Mus musculus	92-99
19034545-1	2009	Sandhoff disease (SD) is a glycosphingolipid (GSL) storage disease that arises from an autosomal recessive mutation in the gene for the beta-subunit of beta-Hexosaminidase A (Hexb gene), which catabolizes ganglioside GM2 within lysosomes.	Gangliosides	205-216	hexosaminidase subunit beta	Homo sapiens	175-179
19221437-8	2009	This revised understanding of the complexities in ganglioside membrane topology provides a mechanistic account for wide variations in the neuropathic potential of anti-GM1 antibodies.	Gangliosides	50-61	coenzyme Q10A	Mus musculus	168-171
19221437-1	2009	Anti-GM1 ganglioside autoantibodies are used as diagnostic markers for motor axonal peripheral neuropathies and are believed to be the primary mediators of such diseases.	Gangliosides	9-20	coenzyme Q10A	Mus musculus	5-8
19221437-4	2009	The cryptic GM1 binding domain was exposed by sialidase treatment that liberated sialic acid from masking gangliosides including GD1a or by disruption of the live membrane by freezing or fixation.	Gangliosides	106-118	coenzyme Q10A	Mus musculus	12-15
19130519-1	2009	Gal-PUGNAc (see picture), a highly selective inhibitor for beta-hexosaminidases HEXA and HEXB is cell-permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels.	Gangliosides	186-197	hexosaminidase subunit alpha	Homo sapiens	80-84
19151629-3	2009	Evidence of ganglioside accumulation, including increases in GM2, GM3, and GD3 and redistribution of GM1, was found throughout the central nervous system (CNS) independent of significant cholesterol accumulation.	Gangliosides	12-23	cytochrome b5 domain containing 2	Mus musculus	61-64
19151629-3	2009	Evidence of ganglioside accumulation, including increases in GM2, GM3, and GD3 and redistribution of GM1, was found throughout the central nervous system (CNS) independent of significant cholesterol accumulation.	Gangliosides	12-23	granulocyte macrophage antigen 3	Mus musculus	66-69
19175312-0	2009	Examination of the biological role of the alpha(2-->6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG).	Gangliosides	80-92	myelin associated glycoprotein	Homo sapiens	108-138
19175312-0	2009	Examination of the biological role of the alpha(2-->6)-linked sialic acid in gangliosides binding to the myelin-associated glycoprotein (MAG).	Gangliosides	80-92	myelin associated glycoprotein	Homo sapiens	140-143
19175312-1	2009	The tetrasaccharide 1, a substructure of ganglioside GQ1b alpha, shows a remarkable affinity for the myelin-associated glycoprotein (MAG) and was therefore selected as starting point for a lead optimization program.	Gangliosides	41-52	myelin associated glycoprotein	Homo sapiens	101-131
19175312-1	2009	The tetrasaccharide 1, a substructure of ganglioside GQ1b alpha, shows a remarkable affinity for the myelin-associated glycoprotein (MAG) and was therefore selected as starting point for a lead optimization program.	Gangliosides	41-52	myelin associated glycoprotein	Homo sapiens	133-136
19724779-8	2009	Moreover, this method can be applied to study concentration of other gangliosides, as shown for GD3 ganglioside.	Gangliosides	69-81	GRDX	Homo sapiens	96-99
19130519-1	2009	Gal-PUGNAc (see picture), a highly selective inhibitor for beta-hexosaminidases HEXA and HEXB is cell-permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels.	Gangliosides	186-197	hexosaminidase subunit beta	Homo sapiens	89-93
19130519-1	2009	Gal-PUGNAc (see picture), a highly selective inhibitor for beta-hexosaminidases HEXA and HEXB is cell-permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels.	Gangliosides	186-197	hexosaminidase subunit alpha	Homo sapiens	142-146
19130519-1	2009	Gal-PUGNAc (see picture), a highly selective inhibitor for beta-hexosaminidases HEXA and HEXB is cell-permeable and modulates the activity of HEXA and HEXB in tissue culture, increasing ganglioside GM2 levels.	Gangliosides	186-197	hexosaminidase subunit beta	Homo sapiens	151-155
18820643-0	2009	Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3.	Gangliosides	187-198	neuraminidase 3	Homo sapiens	43-47
19818222-2	2009	Because expression of the GD3 ganglioside may have an impact on the melanoma malignancy, and therefore on the patient prognosis, we evaluated the feasibility of a retrospective immunohistochemical study of GD3 in paraffin embedded biopsies of primary melanomas.	Gangliosides	30-41	GRDX	Homo sapiens	26-29
19040245-0	2008	Binding epitopes of gangliosides to their neuronal receptor, myelin-associated glycoprotein, from saturation transfer difference NMR.	Gangliosides	20-32	myelin associated glycoprotein	Homo sapiens	61-91
19607978-2	2009	Spontaneous synchronized oscillatory activity of intracellular Ca(2+) between the neurons, which represents synapse formation, was suppressed by the depletion of endogenous gangliosides by d-threo-PDMP, an inhibitor of glucosylceramide synthase.	Gangliosides	173-185	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	219-244
18945680-3	2008	Herein we report that NEU3 plays a key role in skeletal muscle differentiation by strictly modulating the ganglioside content of adjacent cells, with special regard to GM3.	Gangliosides	106-117	neuraminidase 3	Mus musculus	22-26
24351849-2	2008	Ganglioside GM3 [alpha-Neu5Ac-(2-3)-beta-Gal-(1-4)-beta-Glc-(1-1)-ceramide] may impair insulin sensitivity in adipose tissue.	Gangliosides	0-11	insulin	Homo sapiens	87-94
18753612-0	2008	Ganglioside GM1 mediates decapacitation effects of SVS2 on murine spermatozoa.	Gangliosides	0-11	semenogelin 1	Mus musculus	51-55
18753612-6	2008	When the ejaculated spermatozoa were stained with a cholera toxin subunit B (CTB) that preferably interacts with ganglioside GM1, another member of the lipid rafts, the staining pattern of the sperm was the same as the binding pattern of SVS2.	Gangliosides	113-124	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	52-75
18753612-6	2008	When the ejaculated spermatozoa were stained with a cholera toxin subunit B (CTB) that preferably interacts with ganglioside GM1, another member of the lipid rafts, the staining pattern of the sperm was the same as the binding pattern of SVS2.	Gangliosides	113-124	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	77-80
18753612-8	2008	Molecular interaction studies by the overlay assay and the quartz crystal microbalance analysis revealed that SVS2 selectively interacts with GM1 rather than with other gangliosides.	Gangliosides	169-181	semenogelin 1	Mus musculus	110-114
18703820-6	2008	Furthermore, other gangliosides, such as GD2, GD3, GT2, GT3, and GQ1, were also detected in glycosphingolipid standard mixtures from porcine brain and acidic glycolipid extract from mouse brain by theoretically expanded MRM.	Gangliosides	19-31	guanine nucleotide binding protein, alpha transducing 2	Mus musculus	51-54
18815274-9	2008	Together, the data reported here demonstrate that glycosylated SV2A and SV2B act in conjunction with gangliosides to mediate the entry of BoNT/E into neurons.	Gangliosides	101-113	synaptic vesicle glycoprotein 2 a	Mus musculus	63-67
18815274-9	2008	Together, the data reported here demonstrate that glycosylated SV2A and SV2B act in conjunction with gangliosides to mediate the entry of BoNT/E into neurons.	Gangliosides	101-113	synaptic vesicle glycoprotein 2 b	Mus musculus	72-76
18617323-3	2008	Buforin IIb displayed selective cytotoxicity against 62 cancer cell lines by specifically targeting cancer cells through interaction with cell surface gangliosides.	Gangliosides	151-163	ATPase, class II, type 9B	Mus musculus	8-11
18692507-3	2008	We have reported that the Abeta aggregates on ganglioside-rich domains of neuronal PC12 cells as well as in raft-like model membranes.	Gangliosides	46-57	amyloid beta precursor protein	Rattus norvegicus	26-31
18941255-0	2008	Immunization with a mimotope of GD2 ganglioside induces CD8+ T cells that recognize cell adhesion molecules on tumor cells.	Gangliosides	36-47	CD8a molecule	Homo sapiens	56-59
18684516-3	2008	In this study, we suppressed ganglioside biosynthesis in PC12 cells with the glucosylceramide synthase inhibitor, N-butyldeoxynojirimycin and observed reduced plasma membrane antibody binding and a major neuroprotective effect in complement-mediated lysis assays.	Gangliosides	29-40	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	77-102
18761669-2	2008	Prosaposin was demonstrated to form tightly bound complexes with a variety of gangliosides, and a functional role has been suggested for ganglioside-prosaposin complexes.	Gangliosides	78-90	prosaposin	Rattus norvegicus	0-10
18676140-1	2008	AIMS: This study reports the symptom and HRQOL results in which standard treatment was compared to standard therapy plus Bec2, an anti-idiotypic antibody that mimics GD3, a ganglioside antigen.	Gangliosides	173-184	potassium voltage-gated channel subfamily H member 4	Homo sapiens	121-125
18676140-1	2008	AIMS: This study reports the symptom and HRQOL results in which standard treatment was compared to standard therapy plus Bec2, an anti-idiotypic antibody that mimics GD3, a ganglioside antigen.	Gangliosides	173-184	GRDX	Homo sapiens	166-169
18761669-2	2008	Prosaposin was demonstrated to form tightly bound complexes with a variety of gangliosides, and a functional role has been suggested for ganglioside-prosaposin complexes.	Gangliosides	78-89	prosaposin	Rattus norvegicus	0-10
18796718-4	2008	Double immunofluorescence staining of infected HEK-293T cells revealed that NS1 localized with raft-associated molecules, ganglioside GM1 and CD55, on the cell surface.	Gangliosides	122-133	influenza virus NS1A binding protein	Homo sapiens	76-79
18800170-6	2008	Gangliosides in the CNS are characterized by the structure of the long-chain base (LCB) in the ceramide moiety.	Gangliosides	0-12	clathrin, light polypeptide (Lcb)	Mus musculus	66-81
18800170-6	2008	Gangliosides in the CNS are characterized by the structure of the long-chain base (LCB) in the ceramide moiety.	Gangliosides	0-12	clathrin, light polypeptide (Lcb)	Mus musculus	83-86
18800170-7	2008	The LCB of the main ganglioside species has either 18 or 20 carbons (i.e., C18- or C20-sphingosine); we found that these 2 types of gangliosides are differentially distributed in the mouse brain.	Gangliosides	20-31	clathrin, light polypeptide (Lcb)	Mus musculus	4-7
18800170-7	2008	The LCB of the main ganglioside species has either 18 or 20 carbons (i.e., C18- or C20-sphingosine); we found that these 2 types of gangliosides are differentially distributed in the mouse brain.	Gangliosides	132-144	clathrin, light polypeptide (Lcb)	Mus musculus	4-7
18632803-2	2008	Among those forms identified to date, plasma membrane-associated sialidase, Neu3, is a key enzyme in degradation of gangliosides, for which it exhibits a special substrate preference.	Gangliosides	116-128	neuraminidase 3	Homo sapiens	45-80
18718167-1	2008	AIM: To investigate whether valproic acid (VPA) modulates human GM3 synthase (hST3Gal V) mRNA expression, as a part of ganglioside GM3 biosynthesis, in human neuroblastoma cells.	Gangliosides	119-130	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	64-76
18718167-1	2008	AIM: To investigate whether valproic acid (VPA) modulates human GM3 synthase (hST3Gal V) mRNA expression, as a part of ganglioside GM3 biosynthesis, in human neuroblastoma cells.	Gangliosides	119-130	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	78-88
18579701-9	2008	In parallel, increased colocalization of NKCC2 with the LR ganglioside GM1 and their polar translocation were assessed by confocal analysis.	Gangliosides	59-70	solute carrier family 12 member 1	Rattus norvegicus	41-46
18538130-1	2008	We reported that ganglioside GD3 enhances cell proliferation and invasion of melanomas causing stronger tyrosine-phosphorylation of p130Cas and paxillin after stimulation with fetal calf serum.	Gangliosides	17-28	GRDX	Homo sapiens	29-32
18538130-1	2008	We reported that ganglioside GD3 enhances cell proliferation and invasion of melanomas causing stronger tyrosine-phosphorylation of p130Cas and paxillin after stimulation with fetal calf serum.	Gangliosides	17-28	BCAR1 scaffold protein, Cas family member	Homo sapiens	132-139
18588514-2	2008	We previously demonstrated that Hex associated with human fibroblast PM as the mature form, which is functionally active towards G(M2) ganglioside.	Gangliosides	135-146	O-GlcNAcase	Homo sapiens	32-35
18508118-3	2008	More specifically, it is thought that Abeta interacts with ganglioside rich and sialic acid rich regions of cell surfaces.	Gangliosides	59-70	amyloid beta precursor protein	Homo sapiens	38-43
18498441-3	2008	Both ctsd-/- and nclf mice exhibited increased levels of GM2 and GM3 gangliosides.	Gangliosides	69-81	cathepsin D	Mus musculus	5-9
18480157-0	2008	Ganglioside depletion and EGF responses of human GM3 synthase-deficient fibroblasts.	Gangliosides	0-11	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	49-61
18480157-14	2008	We conclude that this GM3 synthase point mutation almost completely depletes human fibroblast cellular gangliosides, dampens membrane EGFR activation, and modulates related critical cell functions such as proliferation and migration.	Gangliosides	103-115	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	22-34
18498441-3	2008	Both ctsd-/- and nclf mice exhibited increased levels of GM2 and GM3 gangliosides.	Gangliosides	69-81	granulocyte macrophage antigen 3	Mus musculus	65-68
18435913-0	2008	Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse osteosarcoma-derived FBJ cells.	Gangliosides	0-11	tumor necrosis factor	Mus musculus	28-36
18471991-1	2008	Gangliosides are sialic acid-conjugated glycosphingolipids that are believed to regulate cell differentiation as well as the signals of several signal molecules, including epidermal growth factor receptors (EGFR).	Gangliosides	0-12	epidermal growth factor receptor	Homo sapiens	207-211
18471991-7	2008	However, treatment with GM3 (1muM) resulted in decreased ALP activation (p<0.01), and treatment of hMSCs with a chemical inhibitor of EGFR, AG1478, removed the differential effect of the two gangliosides.	Gangliosides	194-206	epidermal growth factor receptor	Homo sapiens	137-141
18471991-9	2008	However, AG1478 treatment inhibited the effect of ganglioside GD1a elicitation on EGFR phosphorylation.	Gangliosides	50-61	epidermal growth factor receptor	Homo sapiens	82-86
18767553-8	2008	Thus, inhibitor of tyrosine kinase of Trk-receptors K-252 decreases or practically prevents the ganglioside GM1 neuroprotective effect of PC12 cells under stress conditions; the same ability is characteristic of genistein--an inhibitor of tyrosine kinases of the wider spectrum of action.	Gangliosides	96-107	trunk	Drosophila melanogaster	38-41
18435913-0	2008	Ganglioside GD1a suppresses TNFalpha expression via Pkn1 at the transcriptional level in mouse osteosarcoma-derived FBJ cells.	Gangliosides	0-11	protein kinase N1	Mus musculus	52-56
18435913-5	2008	Man, P. Wang, X. Tan, X. Wang, S. Takaku, S. Hyuga, T. Sato, X. Yao, S. Yamagata, T. Yamagata, Ganglioside GD1a negatively regulates MMP9 expression in mouse FBJ cell lines at the transcriptional level, Connect.	Gangliosides	95-106	matrix metallopeptidase 9	Mus musculus	133-137
18270209-7	2008	Thin-layer chromatography showed increased relative level of GD1a ganglioside and a markedly decreased level of GM1 ganglioside in brain of Neu4(-/-) mice suggesting that Neu4 may be important for desialylation of brain gangliosides and consistent with the in situ hybridization data.	Gangliosides	220-232	sialidase 4	Mus musculus	171-175
18411262-0	2008	Ganglioside inhibition of neurite outgrowth requires Nogo receptor function: identification of interaction sites and development of novel antagonists.	Gangliosides	0-11	reticulon 4 receptor	Homo sapiens	53-66
18411262-2	2008	In this study we show that the ganglioside GT1b can form a complex with the Nogo-66 receptor NgR1.	Gangliosides	31-42	reticulon 4 receptor	Homo sapiens	76-92
18270209-0	2008	Mice deficient in Neu4 sialidase exhibit abnormal ganglioside catabolism and lysosomal storage.	Gangliosides	50-61	sialidase 4	Mus musculus	18-22
18270209-9	2008	Together, our data suggest that Neu4 is a functional component of the ganglioside-metabolizing system, contributing to the postnatal development of the brain and other vital organs.	Gangliosides	70-81	sialidase 4	Mus musculus	32-36
18270209-2	2008	To investigate whether Neu4 is involved in ganglioside catabolism, we transfected beta-hexosaminidase-deficient neuroglia cells from a Tay-Sachs patient with a Neu4-expressing plasmid and demonstrated the correction of storage due to the clearance of accumulated GM2 ganglioside.	Gangliosides	43-54	neuraminidase 4	Homo sapiens	23-27
18235103-5	2008	Our results indicate that: 1) the sperm-associated proteins, P25b and adenylate kinase 1, are linked to DRM of epididymal spermatozoa, but were exclusively associated with detergent-soluble material in ejaculated spermatozoa; 2) seminal plasma treatment of cauda epididymal spermatozoa significantly lowered the content of cholesterol and the ganglioside, GM1, in DRM; and 3), seminal plasma dissociates P25b from DRM in epididymal spermatozoa.	Gangliosides	343-354	P25B	Bos taurus	61-65
18200606-5	2008	For the sialylation analysis of native ganglioside mixtures the MALDI o-TOF analysis with 6-azo-2-thiothymine/diammonium citrate (ATT/DAC) as a matrix appears as an optimal approach for ganglioside profiling.	Gangliosides	39-50	dachshund family transcription factor 1	Mus musculus	134-137
18348864-1	2008	GD3-synthase is a sialyltransferase that catalyzes the synthesis of ganglioside GD3 leading to the b- and c-series gangliosides.	Gangliosides	68-79	GRDX	Homo sapiens	0-3
18348864-1	2008	GD3-synthase is a sialyltransferase that catalyzes the synthesis of ganglioside GD3 leading to the b- and c-series gangliosides.	Gangliosides	68-79	GRDX	Homo sapiens	80-83
18348864-1	2008	GD3-synthase is a sialyltransferase that catalyzes the synthesis of ganglioside GD3 leading to the b- and c-series gangliosides.	Gangliosides	115-127	GRDX	Homo sapiens	0-3
18348864-1	2008	GD3-synthase is a sialyltransferase that catalyzes the synthesis of ganglioside GD3 leading to the b- and c-series gangliosides.	Gangliosides	115-127	GRDX	Homo sapiens	80-83
18339327-3	2008	Northern blot and reverse transcription-polymerase chain reaction (RT-PCR) indicated that the induction of hST3Gal V, which synthesizes ganglioside GM3 and reduction of Neu3 by PMA, are linked for the expression of differentiation marker protein, CD41b surface antigen.	Gangliosides	136-147	tumor-suppressor, HELA cell type	Homo sapiens	107-111
18235103-5	2008	Our results indicate that: 1) the sperm-associated proteins, P25b and adenylate kinase 1, are linked to DRM of epididymal spermatozoa, but were exclusively associated with detergent-soluble material in ejaculated spermatozoa; 2) seminal plasma treatment of cauda epididymal spermatozoa significantly lowered the content of cholesterol and the ganglioside, GM1, in DRM; and 3), seminal plasma dissociates P25b from DRM in epididymal spermatozoa.	Gangliosides	343-354	adenylate kinase 1	Bos taurus	70-88
18316341-12	2008	These results suggest that the AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of the PTEN gene.	Gangliosides	82-93	transcription factor AP-2 alpha	Homo sapiens	31-40
18451570-4	2008	These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor, in which compound 3 showed the most potent activity.	Gangliosides	6-18	nerve growth factor	Rattus norvegicus	115-134
17973185-7	2008	This is in contrast to the mammalian ST3Gal II that predominantly sialylates gangliosides.	Gangliosides	77-89	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	37-46
17973185-9	2008	This suggests that during the evolution of the ST3Gal II, probably following the separation of the teleosts, a significant shift in substrate specificity enabling the sialylation of gangliosides took place.	Gangliosides	182-194	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	Homo sapiens	47-56
18316341-0	2008	The AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene.	Gangliosides	55-66	transcription factor AP-2 alpha	Homo sapiens	4-13
18316341-0	2008	The AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of a PTEN gene.	Gangliosides	55-66	phosphatase and tensin homolog	Homo sapiens	114-118
18316341-12	2008	These results suggest that the AP-2alpha transcription factor is required for the ganglioside GM3-stimulated transcriptional regulation of the PTEN gene.	Gangliosides	82-93	phosphatase and tensin homolog	Homo sapiens	143-147
18194438-1	2008	GM2/GD2 synthase gene knockout mice lack all complex gangliosides, which are abundantly expressed in the nervous systems of vertebrates.	Gangliosides	53-65	cytochrome b5 domain containing 2	Mus musculus	0-3
18354192-2	2008	Though previous studies suggested that tumor-mediated T cell killing is receptor dependent, we recently showed that tumor gangliosides also participate, a notion consistent with reports indicating that, in some cell types, gangliosides can activate the intrinsic apoptotic pathway by stimulating reactive oxygen species production, cytochrome c release, and caspase-9 activation.	Gangliosides	122-134	cytochrome c, somatic	Homo sapiens	332-344
18354163-3	2008	In this study, we show that membrane enrichment of human monocytes with purified exogenous gangliosides potently inhibits ligand-induced activation and proinflammatory cytokine production induced by a broad range of TLRs, including TLR2, TLR3, TLR6, and TLR7/8, in addition to a previously identified inhibitory effect on TLR4 and TLR5.	Gangliosides	91-103	toll like receptor 2	Homo sapiens	232-236
18287616-1	2008	Ganglioside GM3 suppresses the proangiogenic effects of vascular endothelial growth factor and ganglioside GD1a.	Gangliosides	0-11	vascular endothelial growth factor A	Homo sapiens	56-90
18207611-1	2008	Sandhoff disease involves the CNS accumulation of ganglioside GM2 and asialo-GM2 (GA2) due to inherited defects in the beta-subunit gene of beta-hexosaminidase A and B (Hexb gene).	Gangliosides	50-61	cytochrome b5 domain containing 2	Mus musculus	62-80
18207611-1	2008	Sandhoff disease involves the CNS accumulation of ganglioside GM2 and asialo-GM2 (GA2) due to inherited defects in the beta-subunit gene of beta-hexosaminidase A and B (Hexb gene).	Gangliosides	50-61	hexosaminidase B	Mus musculus	169-173
18382692-5	2008	Herein, global lipid profiling demonstrates that Hsp70 membrane-positive tumors differ from their membrane-negative counterparts by containing significantly higher amounts of globotriaoslyceramide (Gb3), but not of other lipids such as lactosylceramide (LacCer), dodecasaccharideceramide (DoCer), galactosylceramide (GalCer), ceramide (Cer), or the ganglioside GM1.	Gangliosides	349-360	Heat-shock-protein-70Ab	Drosophila melanogaster	49-54
18329889-0	2008	Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice.	Gangliosides	0-11	nerve growth factor	Mus musculus	45-64
18329889-0	2008	Ganglioside GM1 effects on the expression of nerve growth factor (NGF), Trk-A receptor, proinflammatory cytokines and on autoimmune diabetes onset in non-obese diabetic (NOD) mice.	Gangliosides	0-11	nerve growth factor	Mus musculus	66-69
18310617-6	2008	For the first time, a description of a ganglioside-differential effect over purified CD4+CD25- and naturally occurring regulatory CD4+CD25+ T cells is provided.	Gangliosides	39-50	CD4 molecule	Homo sapiens	85-88
18310617-6	2008	For the first time, a description of a ganglioside-differential effect over purified CD4+CD25- and naturally occurring regulatory CD4+CD25+ T cells is provided.	Gangliosides	39-50	interleukin 2 receptor subunit alpha	Homo sapiens	89-93
18310617-6	2008	For the first time, a description of a ganglioside-differential effect over purified CD4+CD25- and naturally occurring regulatory CD4+CD25+ T cells is provided.	Gangliosides	39-50	CD4 molecule	Homo sapiens	130-133
18310617-6	2008	For the first time, a description of a ganglioside-differential effect over purified CD4+CD25- and naturally occurring regulatory CD4+CD25+ T cells is provided.	Gangliosides	39-50	interleukin 2 receptor subunit alpha	Homo sapiens	134-138
18354163-3	2008	In this study, we show that membrane enrichment of human monocytes with purified exogenous gangliosides potently inhibits ligand-induced activation and proinflammatory cytokine production induced by a broad range of TLRs, including TLR2, TLR3, TLR6, and TLR7/8, in addition to a previously identified inhibitory effect on TLR4 and TLR5.	Gangliosides	91-103	toll like receptor 3	Homo sapiens	238-242
18354163-3	2008	In this study, we show that membrane enrichment of human monocytes with purified exogenous gangliosides potently inhibits ligand-induced activation and proinflammatory cytokine production induced by a broad range of TLRs, including TLR2, TLR3, TLR6, and TLR7/8, in addition to a previously identified inhibitory effect on TLR4 and TLR5.	Gangliosides	91-103	toll like receptor 6	Homo sapiens	244-248
18354192-2	2008	Though previous studies suggested that tumor-mediated T cell killing is receptor dependent, we recently showed that tumor gangliosides also participate, a notion consistent with reports indicating that, in some cell types, gangliosides can activate the intrinsic apoptotic pathway by stimulating reactive oxygen species production, cytochrome c release, and caspase-9 activation.	Gangliosides	122-134	caspase 9	Homo sapiens	358-367
18354163-3	2008	In this study, we show that membrane enrichment of human monocytes with purified exogenous gangliosides potently inhibits ligand-induced activation and proinflammatory cytokine production induced by a broad range of TLRs, including TLR2, TLR3, TLR6, and TLR7/8, in addition to a previously identified inhibitory effect on TLR4 and TLR5.	Gangliosides	91-103	toll like receptor 7	Homo sapiens	254-258
18354192-2	2008	Though previous studies suggested that tumor-mediated T cell killing is receptor dependent, we recently showed that tumor gangliosides also participate, a notion consistent with reports indicating that, in some cell types, gangliosides can activate the intrinsic apoptotic pathway by stimulating reactive oxygen species production, cytochrome c release, and caspase-9 activation.	Gangliosides	223-235	cytochrome c, somatic	Homo sapiens	332-344
18354163-3	2008	In this study, we show that membrane enrichment of human monocytes with purified exogenous gangliosides potently inhibits ligand-induced activation and proinflammatory cytokine production induced by a broad range of TLRs, including TLR2, TLR3, TLR6, and TLR7/8, in addition to a previously identified inhibitory effect on TLR4 and TLR5.	Gangliosides	91-103	toll like receptor 4	Homo sapiens	322-326
18354192-2	2008	Though previous studies suggested that tumor-mediated T cell killing is receptor dependent, we recently showed that tumor gangliosides also participate, a notion consistent with reports indicating that, in some cell types, gangliosides can activate the intrinsic apoptotic pathway by stimulating reactive oxygen species production, cytochrome c release, and caspase-9 activation.	Gangliosides	223-235	caspase 9	Homo sapiens	358-367
18354163-3	2008	In this study, we show that membrane enrichment of human monocytes with purified exogenous gangliosides potently inhibits ligand-induced activation and proinflammatory cytokine production induced by a broad range of TLRs, including TLR2, TLR3, TLR6, and TLR7/8, in addition to a previously identified inhibitory effect on TLR4 and TLR5.	Gangliosides	91-103	toll like receptor 5	Homo sapiens	331-335
18354192-5	2008	rFasL-mediated apoptosis was completely inhibited in caspase-8- and Fas-associated death domain protein-negative Jurkat cells, though apoptosis induced by purified gangliosides remained intact, findings that correlate with the observed partial inhibition of SK-RC-45-induced apoptosis in the Jurkat lines with defective death receptor signaling.	Gangliosides	164-176	Fas ligand	Rattus norvegicus	0-5
18354163-6	2008	In response to ganglioside enrichment alone, we observed striking up-regulation of IRAK-M in monocytes, but without concomitant proinflammatory cytokine production.	Gangliosides	15-26	interleukin 1 receptor associated kinase 3	Homo sapiens	83-89
18078823-0	2008	Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	133-144	protein tyrosine kinase 2	Homo sapiens	0-21
18428041-0	2008	Patching of ganglioside(M1) in human erythrocytes - distribution of CD47 and CD59 in patched and curved membrane.	Gangliosides	12-23	CD47 molecule	Homo sapiens	68-72
18428041-0	2008	Patching of ganglioside(M1) in human erythrocytes - distribution of CD47 and CD59 in patched and curved membrane.	Gangliosides	12-23	CD59 molecule (CD59 blood group)	Homo sapiens	77-81
18428041-4	2008	Patching of ganglioside(M1) (GM1) by cholera toxin subunit B (CTB) plus anti-CTB resulted in the formation of usually 40-60 GM1 patches distributed over the membrane in discoid erythrocytes.	Gangliosides	12-23	phosphate cytidylyltransferase 1B, choline	Homo sapiens	62-65
18428041-4	2008	Patching of ganglioside(M1) (GM1) by cholera toxin subunit B (CTB) plus anti-CTB resulted in the formation of usually 40-60 GM1 patches distributed over the membrane in discoid erythrocytes.	Gangliosides	12-23	phosphate cytidylyltransferase 1B, choline	Homo sapiens	77-80
18255051-1	2008	Undec-10-enyl, undec-10-ynyl and 11-azidoundecyl glycoside analogues corresponding to the oligosaccharides of human gangliosides GM3, GM2 and GM1 were synthesized in high yields using glycosyltransferases from Campylobacter jejuni.	Gangliosides	116-128	coenzyme Q10A	Mus musculus	142-145
18339884-3	2008	The synergy between tumor-derived TNFalpha and the RCC-overexpressed ganglioside GM1 for killing resting T cells is corroborated by studies using purified GM1 and rTNF alpha, which indicate that a 48-hour pretreatment with the ganglioside optimally sensitizes the lymphocytes to a TNFalpha-induced apoptotic death.	Gangliosides	69-80	tumor necrosis factor	Rattus norvegicus	163-173
18339884-3	2008	The synergy between tumor-derived TNFalpha and the RCC-overexpressed ganglioside GM1 for killing resting T cells is corroborated by studies using purified GM1 and rTNF alpha, which indicate that a 48-hour pretreatment with the ganglioside optimally sensitizes the lymphocytes to a TNFalpha-induced apoptotic death.	Gangliosides	69-80	eiger	Drosophila melanogaster	281-289
18339884-5	2008	RelA-overexpressing lymphocytes are protected from GM1 plus TNFalpha-mediated apoptosis, a finding consistent with our previous studies indicating that gangliosides inhibit nuclear factor-kappaB activation.	Gangliosides	152-164	tumor necrosis factor	Homo sapiens	60-68
18339884-8	2008	This report thus extends our previous studies by demonstrating that tumor-derived TNFalpha enhances RCC apoptogenicity not only by inducing ganglioside synthesis but also by initiating receptor-dependent apoptosis in T cells in which the nuclear factor-kappaB activation pathway has been inhibited by GM1.	Gangliosides	140-151	tumor necrosis factor	Homo sapiens	82-90
18023981-3	2008	Among human sialidases so far identified, sialidase NEU3 is a key enzyme for ganglioside degradation because of its uniqueness both in its localization in the plasma membrane and in specifically hydrolyzing gangliosides.	Gangliosides	77-88	neuraminidase 3	Homo sapiens	52-56
18023981-3	2008	Among human sialidases so far identified, sialidase NEU3 is a key enzyme for ganglioside degradation because of its uniqueness both in its localization in the plasma membrane and in specifically hydrolyzing gangliosides.	Gangliosides	207-219	neuraminidase 3	Homo sapiens	52-56
18072934-2	2008	Here we report that MMP-3 transcription and protein secretion were increased in rat brain astrocytes stimulated with lipopolysaccharide, gangliosides or interferon-gamma.	Gangliosides	137-149	matrix metallopeptidase 3	Rattus norvegicus	20-25
18078823-0	2008	Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	133-144	BCAR1 scaffold protein, Cas family member	Homo sapiens	33-40
18078823-0	2008	Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	133-144	paxillin	Homo sapiens	45-53
18078823-0	2008	Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells.	Gangliosides	133-144	GRDX	Homo sapiens	145-148
18164265-2	2008	The ganglioside GM3 has recently shown to be a negative regulator of insulin sensitivity.	Gangliosides	4-15	insulin	Homo sapiens	69-76
17704805-7	2008	Additionally, surface gangliosides are known to enhance proliferative signaling by the epidermal growth factor (EGF) receptor, providing a possible mechanistic basis for observations that EGF signaling is enhanced in E5-expressing cells.	Gangliosides	22-34	epidermal growth factor receptor	Homo sapiens	87-125
18089699-1	2008	CONTEXT: Complex glycosphingolipids, in majority the ganglioside GM3, surround the insulin receptor in a special membrane compartment (raft) and modulate signaling through this receptor.	Gangliosides	53-64	insulin receptor	Homo sapiens	83-99
18319620-0	2008	Contribution of TLR2 to the initiation of ganglioside-triggered inflammatory signaling.	Gangliosides	42-53	toll like receptor 2	Homo sapiens	16-20
18319620-2	2008	Here we report that TLR2 participates in the initiation of ganglioside-triggered inflammatory signaling responses.	Gangliosides	59-70	toll like receptor 2	Homo sapiens	20-24
18319620-3	2008	Using FACS analysis and immunofluorescence microscopy, we found that gangliosides rapidly enhanced the cell surface expression of TLR2 in microglia, while reducing that of TLR4.	Gangliosides	69-81	toll like receptor 2	Homo sapiens	130-134
18319620-3	2008	Using FACS analysis and immunofluorescence microscopy, we found that gangliosides rapidly enhanced the cell surface expression of TLR2 in microglia, while reducing that of TLR4.	Gangliosides	69-81	toll like receptor 4	Homo sapiens	172-176
18319620-4	2008	The ganglioside-dependent increase of TLR2 expression was also observed at the messenger and protein levels.	Gangliosides	4-15	toll like receptor 2	Homo sapiens	38-42
18319620-5	2008	We also showed that gangliosides stimulate the interaction of TLR2 with Myd88, an adaptor for TLRs, and obtained evidence that lipid raft formation is closely associated with the ganglioside-induced activation of TLR2 and subsequent inflammatory signaling.	Gangliosides	20-32	toll like receptor 2	Homo sapiens	62-66
18319620-5	2008	We also showed that gangliosides stimulate the interaction of TLR2 with Myd88, an adaptor for TLRs, and obtained evidence that lipid raft formation is closely associated with the ganglioside-induced activation of TLR2 and subsequent inflammatory signaling.	Gangliosides	20-32	MYD88 innate immune signal transduction adaptor	Homo sapiens	72-77
18319620-5	2008	We also showed that gangliosides stimulate the interaction of TLR2 with Myd88, an adaptor for TLRs, and obtained evidence that lipid raft formation is closely associated with the ganglioside-induced activation of TLR2 and subsequent inflammatory signaling.	Gangliosides	20-32	toll like receptor 2	Homo sapiens	213-217
18319620-5	2008	We also showed that gangliosides stimulate the interaction of TLR2 with Myd88, an adaptor for TLRs, and obtained evidence that lipid raft formation is closely associated with the ganglioside-induced activation of TLR2 and subsequent inflammatory signaling.	Gangliosides	20-31	toll like receptor 2	Homo sapiens	62-66
18319620-5	2008	We also showed that gangliosides stimulate the interaction of TLR2 with Myd88, an adaptor for TLRs, and obtained evidence that lipid raft formation is closely associated with the ganglioside-induced activation of TLR2 and subsequent inflammatory signaling.	Gangliosides	20-31	MYD88 innate immune signal transduction adaptor	Homo sapiens	72-77
18319620-5	2008	We also showed that gangliosides stimulate the interaction of TLR2 with Myd88, an adaptor for TLRs, and obtained evidence that lipid raft formation is closely associated with the ganglioside-induced activation of TLR2 and subsequent inflammatory signaling.	Gangliosides	20-31	toll like receptor 2	Homo sapiens	213-217
18319620-6	2008	These results collectively suggest that TLR2 contributes to the ability of gangliosides to cause inflammatory conditions in the brain.	Gangliosides	75-87	toll like receptor 2	Homo sapiens	40-44
17907924-12	2008	Galectin-9-induced clustering of lipid rafts detected by cholera toxin B (CTB; binding the raft-resident ganglioside GM1) using confocal microscopy.	Gangliosides	105-116	galectin 9	Homo sapiens	0-10
18272501-0	2008	Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway.	Gangliosides	0-11	CD82 molecule	Homo sapiens	98-102
18272501-0	2008	Ganglioside GM2/GM3 complex affixed on silica nanospheres strongly inhibits cell motility through CD82/cMet-mediated pathway.	Gangliosides	0-11	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	103-107
18272501-1	2008	Ganglioside GM2 complexed with tetraspanin CD82 in glycosynaptic microdomain of HCV29 and other epithelial cells inhibits hepatocyte growth factor-induced cMet tyrosine kinase.	Gangliosides	0-11	CD82 molecule	Homo sapiens	43-47
18272501-1	2008	Ganglioside GM2 complexed with tetraspanin CD82 in glycosynaptic microdomain of HCV29 and other epithelial cells inhibits hepatocyte growth factor-induced cMet tyrosine kinase.	Gangliosides	0-11	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	155-159
17907924-12	2008	Galectin-9-induced clustering of lipid rafts detected by cholera toxin B (CTB; binding the raft-resident ganglioside GM1) using confocal microscopy.	Gangliosides	105-116	phosphate cytidylyltransferase 1B, choline	Homo sapiens	74-77
17928415-5	2008	Based on the above findings of lysosomal permeabilization, we hypothesized that the reduced activity of senescence-associated beta-galactosidase could be responsible for the cellular accumulation of gangliosides, previously shown to induce cell senescence.	Gangliosides	199-211	galactosidase beta 1	Homo sapiens	126-144
17980152-3	2008	Rat MOR in CPu was found mainly associated with low-density cholesterol- and ganglioside M1 (GM1)-enriched membrane subdomains (lipid rafts), while the MOR in the thalamus was present in rafts and non-rafts without preference.	Gangliosides	77-88	opioid receptor, mu 1	Mus musculus	4-7
18097001-3	2008	Our results showed that anti-ganglioside Abs of the IgG1, IgG2b, and IgG3 isotypes were produced in the absence of group 2 CD1 (CD1d) expression.	Gangliosides	29-40	LOC105243590	Mus musculus	52-56
18171481-2	2008	GM3, a precursor for most of the more complex ganglioside species, is synthesized by GM3 synthase.	Gangliosides	46-57	granulocyte macrophage antigen 3	Mus musculus	0-3
18171481-2	2008	GM3, a precursor for most of the more complex ganglioside species, is synthesized by GM3 synthase.	Gangliosides	46-57	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	85-97
18171481-4	2008	METHODS: To investigate the roles of gangliosides in breast tumor development, GM3 synthase was silenced in the highly metastatic 4T1 cells and over-expressed in the non-metastatic 67NR cells.	Gangliosides	37-49	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	79-91
18429602-0	2008	Ganglioside GM1-binding sites in interleukin-4: a photoaffinity labeling study.	Gangliosides	0-11	interleukin 4	Homo sapiens	33-46
18277613-0	2008	Expression of ganglioside GT1b in mouse embryos at different developmental stages after cryopreservation.	Gangliosides	14-25	retinoic acid induced 1	Mus musculus	26-29
18975139-5	2008	We first provide an overview of recent work, starting with findings regarding the amphiphatic amyloid-beta protein (Abeta), which give evidence that membranes can directly promote aggregation, and that the effectiveness in this process can be related to the presence of specific neuronal ganglioside lipids.	Gangliosides	288-299	amyloid beta precursor protein	Homo sapiens	116-121
18405078-6	2008	However, a postoperative decreased proportion of ganglioside GD3 was observed in sera derived from patients with complete tumor removal.	Gangliosides	49-60	GRDX	Homo sapiens	61-64
18097001-3	2008	Our results showed that anti-ganglioside Abs of the IgG1, IgG2b, and IgG3 isotypes were produced in the absence of group 2 CD1 (CD1d) expression.	Gangliosides	29-40	immunoglobulin heavy constant gamma 2B	Mus musculus	58-63
18097001-3	2008	Our results showed that anti-ganglioside Abs of the IgG1, IgG2b, and IgG3 isotypes were produced in the absence of group 2 CD1 (CD1d) expression.	Gangliosides	29-40	Immunoglobulin heavy constant gamma 3	Mus musculus	69-73
18097001-5	2008	Thus, these results indicate CD1-independent pathways for anti-ganglioside Ab production.	Gangliosides	63-74	CD1d1 antigen	Mus musculus	29-32
17708748-1	2007	Sialidase NEU3 is also known as the plasma-membrane-associated form of mammalian sialidases, exhibiting a high substrate specificity towards gangliosides.	Gangliosides	141-153	neuraminidase 3	Homo sapiens	10-14
17708749-11	2007	Moreover, expression in COS7 cells of these novel zebrafish sialidases (with the exception of Neu3.2) induces a significant modification of the ganglioside pattern, consistent with the results obtained with membrane-associated mammalian sialidases.	Gangliosides	144-155	sialidase 3 (membrane sialidase), tandem duplicate 2	Danio rerio	94-100
18173730-0	2008	An exposed carboxyl group on sialic acid is essential for gangliosides to inhibit calcium uptake via the sarco/endoplasmic reticulum Ca2+-ATPase: relevance to gangliosidoses.	Gangliosides	58-70	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	105-144
18173730-1	2008	We previously observed that gangliosides GM2, GM1, and GM3 inhibit Ca2+-uptake via the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in neurons and in brain microsomes.	Gangliosides	28-40	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	87-126
18173730-1	2008	We previously observed that gangliosides GM2, GM1, and GM3 inhibit Ca2+-uptake via the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) in neurons and in brain microsomes.	Gangliosides	28-40	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	128-133
18173730-2	2008	We now systematically examine the effect of various gangliosides and their analogs on Ca2+-uptake via SERCA and demonstrate that an exposed carboxyl group on the ganglioside sialic acid residue is required for inhibition.	Gangliosides	52-64	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	102-107
18173730-2	2008	We now systematically examine the effect of various gangliosides and their analogs on Ca2+-uptake via SERCA and demonstrate that an exposed carboxyl group on the ganglioside sialic acid residue is required for inhibition.	Gangliosides	52-63	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	102-107
18173730-5	2008	Finally, we attempted to use the ceramide-free ganglioside saccharides to antagonize the effects of the gangliosides on SERCA; although some reversal was observed, the inhibitory effects of the gangliosides were not completely abolished.	Gangliosides	104-116	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3	Homo sapiens	120-125
17532287-16	2007	The mechanisms that lead to the inflammatory reaction in cerebral ALD might involve abnormal acylation of gangliosides and phospholipids by VLCFA that would result in immune reaction of brain macrophages and astrocytes bearing CD1 molecules that recognize lipid antigens.	Gangliosides	106-118	CD1c molecule	Homo sapiens	227-230
17708748-7	2007	This evidence is in agreement with the ability of NEU3 to degrade gangliosides inserted into the plasma membrane of adjacent cells.	Gangliosides	66-78	neuraminidase 3	Homo sapiens	50-54
17707652-7	2007	HLA-G expression could be transcriptionally upregulated in RCC by interferons, IL-10 and gangliosides.	Gangliosides	89-101	major histocompatibility complex, class I, G	Homo sapiens	0-5
17883393-5	2007	In E12-E14 brains, GD3 was a predominant ganglioside.	Gangliosides	41-52	GRDX	Homo sapiens	19-22
17883393-11	2007	In parallel studies using primary neural precursor cells in culture as a tool for studying developmental events, dramatic changes in ganglioside and glycosyltransferase gene expression were also detected in neurons induced to differentiate from neural precursor cells, including the expression of GD3, followed by up-regulation of complex a- and b-series gangliosides.	Gangliosides	355-367	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	133-168
17883393-11	2007	In parallel studies using primary neural precursor cells in culture as a tool for studying developmental events, dramatic changes in ganglioside and glycosyltransferase gene expression were also detected in neurons induced to differentiate from neural precursor cells, including the expression of GD3, followed by up-regulation of complex a- and b-series gangliosides.	Gangliosides	355-367	GRDX	Homo sapiens	297-300
17007963-4	2007	Additionally, loss of complex "a" gangliosides (GT1a, GD1a and GM1) was recorded in APP/PS1Ki model, whereas in APP(SL) and APP/PS1 mice, the complex "b" gangliosides (GQ1b, GT1b and GD1b) moderately decreased.	Gangliosides	34-46	presenilin 1	Mus musculus	88-91
18028444-6	2007	Accordingly, hypothyroid mitochondria, with endogenously lower cholesterol and ganglioside content, showed resistance to mPTP opening induced by rBAX.	Gangliosides	79-90	BCL2 associated X, apoptosis regulator	Rattus norvegicus	145-149
18028444-7	2007	These observations suggest that enriched cholesterol and ganglioside domains in the mitochondrial membranes may determine BAX interaction with the mPTP.	Gangliosides	57-68	BCL2 associated X, apoptosis regulator	Rattus norvegicus	122-125
17855525-4	2007	After supplementing glycolipid-deficient GM95 cells with GM1(Ac) and GM1(Gc) gangliosides and the corresponding neoglycolipids with phosphatidylethanolamine lipid groups, it was found that GM1(Gc) analogs conferred better virus binding and infectivity.	Gangliosides	77-89	coenzyme Q10A	Mus musculus	69-76
17994285-1	2007	Sandhoff disease, Gaucher disease type I and sialidosis type I are lysosomal storage disorders caused, respectively, by deficiency of activity of beta-hexosaminidase (storage of GM(2) and GA(2) ganglioside), glucosylceramidase (storage of glucosylceramide) and alpha-neuraminidase (storage of glucopeptides and/or oligosaccharides).	Gangliosides	194-205	O-GlcNAcase	Homo sapiens	146-165
17929901-0	2007	Method for lipidomic analysis: p53 expression modulation of sulfatide, ganglioside, and phospholipid composition of U87 MG glioblastoma cells.	Gangliosides	71-82	tumor protein p53	Homo sapiens	31-34
17929901-9	2007	Also, a decrease in the longer chain gangliosides, GD1 and GM1b, is observed in wild-type p53 (treated) cells.	Gangliosides	37-49	tumor protein p53	Homo sapiens	90-93
17692506-2	2007	To clarify the action of mastoparan on G protein-coupled receptor-mediated signaling, we previously examined the effect of mastoparan on G(q)-mediated signaling and demonstrated that mastoparan binds to gangliosides causing a decrease in Galpha(q/11) content in lipid rafts, and resulting in the inhibition of G(q)-mediated phosphoinositide hydrolysis (Sugama et al., Mol.	Gangliosides	203-215	succinate-CoA ligase GDP/ADP-forming subunit alpha	Homo sapiens	238-249
17761143-1	2007	An acetylated modification of a tumor-associated ganglioside GD3 (9-O-AcGD3) is expressed in certain tumors and present during early stages of development in different tissues.	Gangliosides	49-60	GRDX	Homo sapiens	61-64
17921865-1	2007	We performed an immunohistochemical analysis of the GM1 ganglioside-bound amyloid beta-protein (GAbeta), an endogenous seed of Alzheimer amyloids, in sections of cerebral cortices of cynomolgus monkeys of different ages from 4 to 36 years old.	Gangliosides	56-67	lysosomal alpha-glucosidase	Macaca fascicularis	96-102
17887730-4	2007	We have examined the effect of lipid membranes containing negatively charged ganglioside, an important component of caveolae, on the secondary structure of PrP106-126 by circular dichroism.	Gangliosides	77-88	prion protein	Homo sapiens	156-166
17887730-5	2007	The peptide forms an alpha-helical or a beta-sheet structure on the ganglioside-containing membranes.	Gangliosides	68-79	amyloid beta precursor protein	Homo sapiens	38-44
17887730-8	2007	Since ganglioside-containing membranes also exhibit lateral phase separation, clustered negative charges are concluded to be responsible for the beta-sheet formation of PrP106-126.	Gangliosides	6-17	prion protein	Homo sapiens	169-179
17887730-9	2007	In caveolae, clustered ganglioside molecules are likely to interact with the residue 106-126 region of PrPC to promote the PrPC-to-PrPSc conversion.	Gangliosides	23-34	prion protein	Homo sapiens	103-107
17887730-9	2007	In caveolae, clustered ganglioside molecules are likely to interact with the residue 106-126 region of PrPC to promote the PrPC-to-PrPSc conversion.	Gangliosides	23-34	prion protein	Homo sapiens	123-127
17464449-0	2007	Hepatocyte growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells.	Gangliosides	53-65	hepatocyte growth factor	Homo sapiens	0-24
17922964-3	2007	In human milk, the content and individual distribution of gangliosides changes during lactation, GD3 being the most abundant ganglioside in colostrum, while in mature milk, GM3 is the major individual species.	Gangliosides	58-70	GRDX	Homo sapiens	97-100
17922964-3	2007	In human milk, the content and individual distribution of gangliosides changes during lactation, GD3 being the most abundant ganglioside in colostrum, while in mature milk, GM3 is the major individual species.	Gangliosides	58-69	GRDX	Homo sapiens	97-100
17922964-8	2007	Recently, the influence of GM3 and GD3 on dendritic cell maturation and effector functionalities has also been reported, suggesting a role for these milk gangliosides, especially GD3, in modulating the process of oral tolerance during first stages of life.	Gangliosides	154-166	GRDX	Homo sapiens	35-38
17464449-3	2007	TGF-beta isoforms and gangliosides were found to differentially stimulate HGF production by these cells.	Gangliosides	22-34	hepatocyte growth factor	Homo sapiens	74-77
17464449-4	2007	The ganglioside GD3 enhanced this release to the greatest extent and the stimulation was more marked in a glioblastoma cell line than in the two other anaplastic astrocytoma cell lines.	Gangliosides	4-15	GRDX	Homo sapiens	16-19
17464449-5	2007	These results suggest that both TGF-betas and gangliosides may act as indirect angiogenic factors by stimulating HGF secretion.	Gangliosides	46-58	hepatocyte growth factor	Homo sapiens	113-116
17440688-2	2007	Both express the same gangliosides (GM3, GM2, GM1 and GD1a), which are resolved as doublets on HPTLC.	Gangliosides	22-34	granulocyte macrophage antigen 3	Mus musculus	36-39
17640868-0	2007	Gangliosides and Nogo receptors independently mediate myelin-associated glycoprotein inhibition of neurite outgrowth in different nerve cells.	Gangliosides	0-12	myelin-associated glycoprotein	Rattus norvegicus	54-84
17640868-3	2007	We used enzymes and pharmacological agents to distinguish the relative roles of gangliosides and NgRs in MAG-mediated inhibition of neurite outgrowth from three nerve cell types, dorsal root ganglion neurons (DRGNs), cerebellar granule neurons (CGNs), and hippocampal neurons.	Gangliosides	80-92	myelin-associated glycoprotein	Rattus norvegicus	105-108
17640868-13	2007	Our data indicate that MAG inhibits axon outgrowth via two independent receptors, gangliosides and NgRs.	Gangliosides	82-94	myelin-associated glycoprotein	Rattus norvegicus	23-26
17827720-9	2007	These results indicate that Neu3 is up-regulated in Jurkat cells undergoing etoposide-induced apoptosis through intracellular signaling events downstream of caspase 3 activation and that enhanced Neu3 activity is closely related to the changes of cell surface ganglioside composition.	Gangliosides	260-271	neuraminidase 3	Homo sapiens	28-32
17827720-9	2007	These results indicate that Neu3 is up-regulated in Jurkat cells undergoing etoposide-induced apoptosis through intracellular signaling events downstream of caspase 3 activation and that enhanced Neu3 activity is closely related to the changes of cell surface ganglioside composition.	Gangliosides	260-271	neuraminidase 3	Homo sapiens	196-200
17604219-0	2007	Alteration of ganglioside synthesis by GM3 synthase knockout in murine embryonic fibroblasts.	Gangliosides	14-25	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	39-51
17604219-3	2007	We found that heterozygote MEF (GM3S+/-) did have a 36% reduced content of qualitatively normal gangliosides (7.0+/-0.8 nmol LBSA/mg cell protein; control: 11+/-1.6 nmol).	Gangliosides	96-108	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	32-36
17567107-4	2007	The ganglioside GM1 was tagged with the fluorescent dye tetramethylrhodamine.	Gangliosides	4-15	coenzyme Q10A	Mus musculus	16-19
17597153-2	2007	Liposomal studies have proposed that Abeta-(1-40) preferentially recognizes a cholesterol-dependent cluster of gangliosides and a conformationally altered form of Abeta promotes the aggregation of the protein.	Gangliosides	111-123	amyloid beta precursor protein	Rattus norvegicus	37-42
17597153-5	2007	Abeta-(1-42) preferentially bound to ganglioside and cholesterol-rich domains of cell membranes and formed amyloids in a time-dependent manner.	Gangliosides	37-48	amyloid beta precursor protein	Rattus norvegicus	0-5
17597153-6	2007	These observations corroborate the model involving ganglioside-mediated accumulation of Abeta.	Gangliosides	51-62	amyloid beta precursor protein	Rattus norvegicus	88-93
17597153-7	2007	The NGF-induced differentiation of PC12 cells into neuron-like cells caused a marked increase in both gangliosides and cholesterol, and thereby greatly potentiated the accumulation and cytotoxicity of Abeta-(1-42).	Gangliosides	102-114	amyloid beta precursor protein	Rattus norvegicus	201-206
17597153-8	2007	NGF-differentiated cells exposed to Abeta-(1-42) had degenerated neurites, in which ganglioside and cholesterol-rich domains were localized, preceding cell death.	Gangliosides	84-95	amyloid beta precursor protein	Rattus norvegicus	36-41
17321494-6	2007	Regarding the role of gangliosides in the facilitation of Abeta assembly, it has recently been reported that region-specific deposition of hereditary variant-type Abetas is determined by local gangliosides in the brain.	Gangliosides	22-34	amyloid beta precursor protein	Homo sapiens	58-63
17651125-4	2007	Further analysis of the GFP:STLT(B) product confirmed its ganglioside-binding ability, LT(B) antigenicity and relative freedom from the ST-associated toxicity, making it suitable for use as an oral vaccine in mice.	Gangliosides	58-69	lymphotoxin B	Mus musculus	30-35
17507233-1	2007	The trisaccharide substructure 13 of the ganglioside GQ1balpha shows a remarkable affinity for the myelin-associated glycoprotein (MAG).	Gangliosides	41-52	myelin associated glycoprotein	Homo sapiens	99-129
17507233-1	2007	The trisaccharide substructure 13 of the ganglioside GQ1balpha shows a remarkable affinity for the myelin-associated glycoprotein (MAG).	Gangliosides	41-52	myelin associated glycoprotein	Homo sapiens	131-134
17699617-0	2007	Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.	Gangliosides	63-74	Insulin-like receptor	Drosophila melanogaster	20-36
17699617-0	2007	Dissociation of the insulin receptor and caveolin-1 complex by ganglioside GM3 in the state of insulin resistance.	Gangliosides	63-74	Insulin-like receptor	Drosophila melanogaster	20-27
17699617-2	2007	We previously demonstrated that, in adipocytes in a state of TNFalpha-induced insulin resistance, the inhibition of insulin metabolic signaling and the elimination of insulin receptors (IR) from the caveolae microdomains were associated with an accumulation of the ganglioside GM3.	Gangliosides	265-276	eiger	Drosophila melanogaster	61-69
17699617-2	2007	We previously demonstrated that, in adipocytes in a state of TNFalpha-induced insulin resistance, the inhibition of insulin metabolic signaling and the elimination of insulin receptors (IR) from the caveolae microdomains were associated with an accumulation of the ganglioside GM3.	Gangliosides	265-276	Insulin-like receptor	Drosophila melanogaster	116-123
17699617-2	2007	We previously demonstrated that, in adipocytes in a state of TNFalpha-induced insulin resistance, the inhibition of insulin metabolic signaling and the elimination of insulin receptors (IR) from the caveolae microdomains were associated with an accumulation of the ganglioside GM3.	Gangliosides	265-276	Insulin-like receptor	Drosophila melanogaster	116-123
17321494-6	2007	Regarding the role of gangliosides in the facilitation of Abeta assembly, it has recently been reported that region-specific deposition of hereditary variant-type Abetas is determined by local gangliosides in the brain.	Gangliosides	193-205	amyloid beta precursor protein	Homo sapiens	58-63
17382287-5	2007	The importance of ganglioside clusters in the aggregation of Abeta is emphasized.	Gangliosides	18-29	amyloid beta precursor protein	Homo sapiens	61-66
17623103-2	2007	The beta-subunit together with the GM2 activator protein catabolize ganglioside GM2.	Gangliosides	68-79	cytochrome b5 domain containing 2	Mus musculus	35-38
17623103-2	2007	The beta-subunit together with the GM2 activator protein catabolize ganglioside GM2.	Gangliosides	68-79	cytochrome b5 domain containing 2	Mus musculus	80-83
17325693-7	2007	However, our data show that the specificity of CTB for GM1 ganglioside is limited, because the binding capacity is partly resistant to inhibition of ganglioside synthesis and sensitive to trypsin digestion.	Gangliosides	59-70	phosphate cytidylyltransferase 1B, choline	Homo sapiens	47-50
17521961-0	2007	Ganglioside GM(3) is stably associated to tyrosine-phosphorylated ErbB2/EGFR receptor complexes and EGFR monomers, but not to ErbB2.	Gangliosides	0-11	erb-b2 receptor tyrosine kinase 2	Homo sapiens	66-71
17521961-0	2007	Ganglioside GM(3) is stably associated to tyrosine-phosphorylated ErbB2/EGFR receptor complexes and EGFR monomers, but not to ErbB2.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	72-76
17521961-0	2007	Ganglioside GM(3) is stably associated to tyrosine-phosphorylated ErbB2/EGFR receptor complexes and EGFR monomers, but not to ErbB2.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	100-104
17521961-2	2007	Recently, we demonstrated the functional relationship between ErbB2 and ganglioside GM(3) in HC11 epithelial cell line.	Gangliosides	72-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-67
17488728-5	2007	In addition, a significant accumulation of the major ganglioside GM1 and reduced SM was detected in the myelin fraction of ABCA2-null brain.	Gangliosides	53-64	ATP-binding cassette, sub-family A (ABC1), member 2	Mus musculus	123-128
17325693-8	2007	Our results indicate that the binding of FITC-labeled CTB can be divided into at least three different categories: a specific binding of CTB to ganglioside GM1, a nonspecific binding of CTB probably to glycosylated surface proteins and a nonspecific binding of FITC to the cell surface.	Gangliosides	144-155	phosphate cytidylyltransferase 1B, choline	Homo sapiens	54-57
17325693-8	2007	Our results indicate that the binding of FITC-labeled CTB can be divided into at least three different categories: a specific binding of CTB to ganglioside GM1, a nonspecific binding of CTB probably to glycosylated surface proteins and a nonspecific binding of FITC to the cell surface.	Gangliosides	144-155	phosphate cytidylyltransferase 1B, choline	Homo sapiens	137-140
17325693-8	2007	Our results indicate that the binding of FITC-labeled CTB can be divided into at least three different categories: a specific binding of CTB to ganglioside GM1, a nonspecific binding of CTB probably to glycosylated surface proteins and a nonspecific binding of FITC to the cell surface.	Gangliosides	144-155	phosphate cytidylyltransferase 1B, choline	Homo sapiens	137-140
17333390-2	2007	Organism integrity requires a tight balance between the anabolic and catabolic processes, thus it is important to control the intracellular expression of those "key" enzymes, which act at the "branching point" of ganglioside metabolism; one of these is the GD3-synthase (ST8Sia I).	Gangliosides	213-224	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 L homeolog	Xenopus laevis	257-269
17333390-2	2007	Organism integrity requires a tight balance between the anabolic and catabolic processes, thus it is important to control the intracellular expression of those "key" enzymes, which act at the "branching point" of ganglioside metabolism; one of these is the GD3-synthase (ST8Sia I).	Gangliosides	213-224	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 L homeolog	Xenopus laevis	271-279
17475896-7	2007	Our results indicate that TNF-alpha signaling promotes RCC-induced killing of T cells by stimulating the acquisition of a distinct ganglioside assembly in RCC tumor cells.	Gangliosides	131-142	eiger	Drosophila melanogaster	26-35
17392511-0	2007	Gangliosides GM1 and GM3 in the living cell membrane form clusters susceptible to cholesterol depletion and chilling.	Gangliosides	0-12	coenzyme Q10A	Mus musculus	13-16
17392511-2	2007	In the present paper, we examined the distribution of gangliosides GM1 and GM3, putative raft molecules in the cell membrane, by immunoelectron microscopy using quick-frozen and freeze-fractured specimens.	Gangliosides	54-66	coenzyme Q10A	Mus musculus	67-70
17510604-1	2007	Our previous study demonstrated that feeding ganglioside increased total ganglioside content while decreasing cholesterol and caveolin-1 content in developing rat intestinal lipid microdomains.	Gangliosides	45-56	caveolin 1	Rattus norvegicus	126-136
17511990-4	2007	The effects of the GCS inhibitor on impairment of CXCL12-induced cell migration temporally correlated with a pronounced downregulation of neutral glycosphingolipids, particularly glucosylceramide, and with a delayed and more moderate downregulation of gangliosides; moreover, exogenously administered glycosphingolipids allowed resumption of CXCR4-dependent chemotaxis.	Gangliosides	252-264	UDP-glucose ceramide glucosyltransferase	Homo sapiens	19-22
17511990-4	2007	The effects of the GCS inhibitor on impairment of CXCL12-induced cell migration temporally correlated with a pronounced downregulation of neutral glycosphingolipids, particularly glucosylceramide, and with a delayed and more moderate downregulation of gangliosides; moreover, exogenously administered glycosphingolipids allowed resumption of CXCR4-dependent chemotaxis.	Gangliosides	252-264	C-X-C motif chemokine ligand 12	Homo sapiens	50-56
17543577-7	2007	Studies of purified SCP-2 and in cells show that SCP-2 has high affinity for and selectively transfers many lipid species involved in intracellular signaling: fatty acids, fatty acyl CoAs, lysophosphatidic acid, phosphatidylinositols, and sphingolipids (sphingomyelin, ceramide, mono-di-and multi-hexosylceramides, gangliosides).	Gangliosides	315-327	sterol carrier protein 2, liver	Mus musculus	49-54
17367758-0	2007	Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.	Gangliosides	54-65	tumor necrosis factor	Mus musculus	23-50
17382908-1	2007	The ganglioside-specific sialidase Neu3 has been suggested to participate in cell growth, migration, and differentiation.	Gangliosides	4-15	neuraminidase 3	Homo sapiens	35-39
17429973-1	2007	The present studies explore multivalent ligand-receptor interactions between pentameric cholera toxin B subunits (CTB) and the corresponding membrane ligand, ganglioside GM1.	Gangliosides	158-169	phosphate cytidylyltransferase 1B, choline	Homo sapiens	114-117
17367758-0	2007	Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.	Gangliosides	54-65	granulocyte macrophage antigen 3	Mus musculus	66-69
17367758-0	2007	Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.	Gangliosides	54-65	thymoma viral proto-oncogene 1	Mus musculus	78-81
17334392-1	2007	Human plasma membrane-associated sialidase (NEU3), a key enzyme for ganglioside degradation, is markedly upregulated in human cancers, leading to apoptosis suppression.	Gangliosides	68-79	neuraminidase 3	Homo sapiens	13-48
17470562-1	2007	Previous reports have shown that glycosphingolipids can modulate the activity of the insulin receptor, and studies in transgenic mice suggest a link between altered levels of various gangliosides and the development of insulin resistance.	Gangliosides	183-195	insulin receptor	Mus musculus	85-101
17352383-3	2007	We found that antibody to ganglioside GM1 labels paranodal regions.	Gangliosides	26-37	coenzyme Q10A	Mus musculus	38-41
17352383-4	2007	Autoantibodies to the gangliosides GM1 and GD1a are thought to disrupt nodes of Ranvier in peripheral motor nerves and cause Guillain-Barre syndrome, an autoimmune neuropathy characterized by acute limb weakness.	Gangliosides	22-34	coenzyme Q10A	Mus musculus	35-38
17368571-1	2007	The function of gangliosides, sialic acid-containing glycolipids, on the secretion and assembly of apoB-containing lipoproteins is poorly understood.	Gangliosides	16-28	apolipoprotein B	Homo sapiens	99-103
17332365-7	2007	For this purpose, IL-2 was targeted to ganglioside GD2, which is highly expressed on neuroblastoma tissue, using an anti-GD2 antibody IL-2 immunocytokine (ch14.18-IL-2).	Gangliosides	39-50	interleukin 2	Mus musculus	18-22
17284246-0	2007	Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties.	Gangliosides	84-95	caveolin 1	Homo sapiens	18-28
17284246-0	2007	Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties.	Gangliosides	84-95	GRDX	Homo sapiens	96-99
17264085-9	2007	Consistent with this, there was a time-dependent increase in colocalization between IK1 and the lipid raft ganglioside GM1 on the plasma membrane, which subsequently decreased with volume recovery.	Gangliosides	107-118	potassium calcium-activated channel subfamily N member 4	Rattus norvegicus	84-87
17164410-0	2007	Mast cell-specific gangliosides and FcepsilonRI follow the same endocytic pathway from lipid rafts in RBL-2H3 cells.	Gangliosides	19-31	RB transcriptional corepressor like 2	Rattus norvegicus	102-107
17409686-4	2007	We have found a selective increase in the acidic glycosphingolipid ganglioside GM3 in 3T3-L1 adipocytes treated with TNFalpha, suggesting a specific function for GM3.	Gangliosides	67-78	tumor necrosis factor	Rattus norvegicus	117-125
17215249-0	2007	Ganglioside GM2-tetraspanin CD82 complex inhibits met and its cross-talk with integrins, providing a basis for control of cell motility through glycosynapse.	Gangliosides	0-11	CD82 molecule	Homo sapiens	28-32
17215249-9	2007	(i) Ganglioside GM2, but not GM3 or globoside, interacted specifically with tetraspanin CD82, and such a complex inhibited hepatocyte growth factor (HGF)-induced activation of Met tyrosine kinase in a dose-dependent manner.	Gangliosides	4-15	CD82 molecule	Homo sapiens	88-92
17215249-9	2007	(i) Ganglioside GM2, but not GM3 or globoside, interacted specifically with tetraspanin CD82, and such a complex inhibited hepatocyte growth factor (HGF)-induced activation of Met tyrosine kinase in a dose-dependent manner.	Gangliosides	4-15	hepatocyte growth factor	Homo sapiens	123-147
17215249-9	2007	(i) Ganglioside GM2, but not GM3 or globoside, interacted specifically with tetraspanin CD82, and such a complex inhibited hepatocyte growth factor (HGF)-induced activation of Met tyrosine kinase in a dose-dependent manner.	Gangliosides	4-15	hepatocyte growth factor	Homo sapiens	149-152
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	59-70	CD4 molecule	Homo sapiens	82-85
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	59-70	integrin subunit alpha L	Homo sapiens	251-256
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	59-70	integrin subunit alpha L	Homo sapiens	258-298
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	59-70	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	307-332
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	59-70	CD4 molecule	Homo sapiens	82-85
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	174-185	CD4 molecule	Homo sapiens	45-48
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	174-185	integrin subunit alpha L	Homo sapiens	251-256
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	174-185	integrin subunit alpha L	Homo sapiens	258-298
17123354-1	2007	We previously showed that the association of CD4 and G(M3) ganglioside induced by CD4 ligand binding was required for the down-regulation of adhesion and that aggregation of ganglioside-enriched domains was accompanied by transient co-localization of LFA-1 (lymphocyte function-associated antigen-1), PI3K (phosphoinositide 3-kinase) and CD4.	Gangliosides	174-185	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	307-332
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	CD4 molecule	Homo sapiens	35-38
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	cyclin dependent kinase like 2	Homo sapiens	39-42
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	43-46
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	CD4 molecule	Homo sapiens	63-66
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	cyclin dependent kinase like 2	Homo sapiens	116-119
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	integrin subunit alpha L	Homo sapiens	135-140
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	CD4 molecule	Homo sapiens	63-66
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	cyclin dependent kinase like 2	Homo sapiens	116-119
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	144-155	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	CD4 molecule	Homo sapiens	35-38
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	cyclin dependent kinase like 2	Homo sapiens	39-42
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	43-46
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	CD4 molecule	Homo sapiens	63-66
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	cyclin dependent kinase like 2	Homo sapiens	116-119
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	integrin subunit alpha L	Homo sapiens	135-140
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	CD4 molecule	Homo sapiens	63-66
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	cyclin dependent kinase like 2	Homo sapiens	116-119
17123354-3	2007	In the present study, we show that CD4-p56(lck) association in CD4 signalling is required for the redistribution of p56(lck), PI3K and LFA-1 in ganglioside-enriched domains, since ganglioside aggregation and recruitment of these proteins were not observed in a T-cell line (A201) expressing the mutant form of CD4 that does not bind p56(lck).	Gangliosides	180-191	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	120-123
17123354-5	2007	Gangliosides could associate with these proteins that differ in affinity binding and could be modified following CD4 signalling.	Gangliosides	0-12	CD4 molecule	Homo sapiens	113-116
17123354-6	2007	Our results suggest that through these associations, gangliosides transiently sequestrate these proteins and consequently inhibit LFA-1-dependent adhesion.	Gangliosides	53-65	integrin subunit alpha L	Homo sapiens	130-135
17123354-7	2007	Furthermore, while structural diversity of gangliosides may allow association with distinct proteins, we show that the tyrosine phosphatase SHP-2 (Src homology 2 domain-containing protein tyrosine phosphatase 2), also required for the down-regulation of LFA-1-dependent adhesion, transiently and partially co-localized with PI3K and p56(lck) in detergent-insoluble membranes without association with G(M1) or G(M3).	Gangliosides	43-55	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	140-145
17123354-8	2007	We propose that CD4 ligation and binding with p56(lck) and their interaction with G(M3) and/or G(M1) gangliosides induce recruitment of distinct proteins important for CD4 signalling to form a multimolecular signalling complex.	Gangliosides	101-113	CD4 molecule	Homo sapiens	16-19
17123354-8	2007	We propose that CD4 ligation and binding with p56(lck) and their interaction with G(M3) and/or G(M1) gangliosides induce recruitment of distinct proteins important for CD4 signalling to form a multimolecular signalling complex.	Gangliosides	101-113	cyclin dependent kinase like 2	Homo sapiens	46-49
17123354-8	2007	We propose that CD4 ligation and binding with p56(lck) and their interaction with G(M3) and/or G(M1) gangliosides induce recruitment of distinct proteins important for CD4 signalling to form a multimolecular signalling complex.	Gangliosides	101-113	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	50-53
17123354-8	2007	We propose that CD4 ligation and binding with p56(lck) and their interaction with G(M3) and/or G(M1) gangliosides induce recruitment of distinct proteins important for CD4 signalling to form a multimolecular signalling complex.	Gangliosides	101-113	CD4 molecule	Homo sapiens	168-171
17332365-7	2007	For this purpose, IL-2 was targeted to ganglioside GD2, which is highly expressed on neuroblastoma tissue, using an anti-GD2 antibody IL-2 immunocytokine (ch14.18-IL-2).	Gangliosides	39-50	interleukin 2	Mus musculus	134-138
17332365-7	2007	For this purpose, IL-2 was targeted to ganglioside GD2, which is highly expressed on neuroblastoma tissue, using an anti-GD2 antibody IL-2 immunocytokine (ch14.18-IL-2).	Gangliosides	39-50	interleukin 2	Mus musculus	134-138
17256880-1	2007	There is increasing evidence that a class of cell membrane glycolipids, gangliosides, can mediate the fibrillogenesis and toxicity of Alzheimer"s disease amyloid-beta peptide (Abeta).	Gangliosides	72-84	beta amyloid protein precursor-like	Drosophila melanogaster	176-181
17489102-6	2007	Our data show that MRP1 was exclusively found in "light" fractions known as L0 phase membrane microdomains, together with 23% of gangliosides GM1 and 40% of caveolin-1.	Gangliosides	129-141	ATP binding cassette subfamily C member 1	Homo sapiens	19-23
17292733-10	2007	These results suggest that hepatic NEU3 overexpression improves insulin sensitivity and glucose tolerance through modification of ganglioside composition and peroxisome proliferator-activated receptor gamma signaling.	Gangliosides	130-141	neuraminidase 3	Mus musculus	35-39
17253773-3	2007	We examined the interactions between several brain sphingolipids and alpha-synuclein and found that alpha-synuclein specifically binds to ganglioside GM1-containing small unilamellar vesicles (SUVs).	Gangliosides	138-149	synuclein alpha	Homo sapiens	100-115
17253773-5	2007	SUVs containing total brain gangliosides, gangliosides GM2 or GM3, or asialo-GM1 had weak inhibitory effects on alpha-synuclein fibrillation and induced some alpha-helical structure, while all other sphingolipids studied showed negligible interaction with alpha-synuclein.	Gangliosides	28-40	synuclein alpha	Homo sapiens	112-127
17253773-5	2007	SUVs containing total brain gangliosides, gangliosides GM2 or GM3, or asialo-GM1 had weak inhibitory effects on alpha-synuclein fibrillation and induced some alpha-helical structure, while all other sphingolipids studied showed negligible interaction with alpha-synuclein.	Gangliosides	42-54	synuclein alpha	Homo sapiens	112-127
17295843-3	2007	Here, we investigate whether the xUPIII-xUPIb complex is in close proximity to CD9, a tetraspanin that has been implicated in the sperm-egg fusion in the mouse and GM1, a ganglioside typically enriched in egg rafts.	Gangliosides	171-182	CD9 antigen	Mus musculus	79-82
17234188-0	2007	Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites.	Gangliosides	42-53	GRDX	Homo sapiens	54-57
17295843-3	2007	Here, we investigate whether the xUPIII-xUPIb complex is in close proximity to CD9, a tetraspanin that has been implicated in the sperm-egg fusion in the mouse and GM1, a ganglioside typically enriched in egg rafts.	Gangliosides	171-182	coenzyme Q10A	Mus musculus	164-167
16971381-6	2007	In contrast, the neuraminidase inhibitor, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, specific for plasma membrane ganglioside Neu3 and Neu2 sialidases has no inhibitory effect on NGF-induced pTrkA.	Gangliosides	116-127	neuraminidase 1	Homo sapiens	17-30
17118982-0	2007	Mutants of type II heat-labile enterotoxin LT-IIa with altered ganglioside-binding activities and diminished toxicity are potent mucosal adjuvants.	Gangliosides	63-74	ATPase, class II, type 9A	Mus musculus	46-49
17118982-2	2007	While LT-IIa is a potent systemic and mucosal adjuvant, recent studies demonstrated that mutant LT-IIa(T34I), which exhibits no detectable binding activity as determined by an enzyme-linked immunosorbent assay, with gangliosides GD1b, GD1a, and GM1 is a very poor adjuvant.	Gangliosides	216-228	ATPase, class II, type 9A	Mus musculus	99-102
17202469-2	2007	For example, the endogenous lectin, myelin-associated glycoprotein (MAG), is reported to bind to axonal gangliosides (GD1a and GT1b) to inhibit neurite outgrowth.	Gangliosides	104-116	myelin associated glycoprotein	Homo sapiens	36-66
17202469-2	2007	For example, the endogenous lectin, myelin-associated glycoprotein (MAG), is reported to bind to axonal gangliosides (GD1a and GT1b) to inhibit neurite outgrowth.	Gangliosides	104-116	myelin associated glycoprotein	Homo sapiens	68-71
17135262-0	2007	A ganglioside-induced toxic soluble Abeta assembly.	Gangliosides	2-13	amyloid beta precursor protein	Homo sapiens	36-41
17135262-4	2007	TAbeta is also formed from soluble Abeta through incubation with natural neuronal membranes prepared from aged mouse brains in a GM1 ganglioside-dependent manner.	Gangliosides	133-144	histocompatibility 2, class II antigen A, beta 1	Mus musculus	1-6
17135262-4	2007	TAbeta is also formed from soluble Abeta through incubation with natural neuronal membranes prepared from aged mouse brains in a GM1 ganglioside-dependent manner.	Gangliosides	133-144	coenzyme Q10A	Mus musculus	129-132
17653976-0	2007	Ganglioside GD1a negatively regulates matrix metalloproteinase-9 expression in mouse FBJ cell lines at the transcriptional level.	Gangliosides	0-11	matrix metallopeptidase 9	Mus musculus	38-64
16971381-6	2007	In contrast, the neuraminidase inhibitor, 2-deoxy-2,3-dehydro-N-acetylneuraminic acid, specific for plasma membrane ganglioside Neu3 and Neu2 sialidases has no inhibitory effect on NGF-induced pTrkA.	Gangliosides	116-127	neuraminidase 3	Homo sapiens	128-132
17098818-6	2007	We also show that TREM-1 is recruited to ganglioside M1-lipid rafts in PMN upon stimulation with LPS or anti-TREM-1.	Gangliosides	41-52	triggering receptor expressed on myeloid cells 1	Homo sapiens	18-24
17098818-6	2007	We also show that TREM-1 is recruited to ganglioside M1-lipid rafts in PMN upon stimulation with LPS or anti-TREM-1.	Gangliosides	41-52	triggering receptor expressed on myeloid cells 1	Homo sapiens	109-115
17161396-0	2006	Chloroquine-induced endocytic pathway abnormalities: Cellular model of GM1 ganglioside-induced Abeta fibrillogenesis in Alzheimer"s disease.	Gangliosides	75-86	beta amyloid protein precursor-like	Drosophila melanogaster	95-100
16859490-0	2006	Gangliosides play an important role in the organization of CD82-enriched microdomains.	Gangliosides	0-12	CD82 molecule	Homo sapiens	59-63
16859490-6	2006	The destabilization of the CD82-containing complexes upon ganglioside depletion correlated with the re-distribution of the proteins within plasma membrane.	Gangliosides	58-69	CD82 molecule	Homo sapiens	27-31
16859490-7	2006	Importantly, depletion of gangliosides affected EGF-induced signalling only in the presence of CD82.	Gangliosides	26-38	CD82 molecule	Homo sapiens	95-99
16859490-8	2006	Taken together, our results provide strong evidence that gangliosides play an important role in supporting the integrity of CD82-enriched microdomains.	Gangliosides	57-69	CD82 molecule	Homo sapiens	124-128
16817235-4	2006	These studies provide, for the first time, an approach for studying the molecular mechanisms involved in the in vivo regulation of EGFr function by gangliosides.	Gangliosides	148-160	epidermal growth factor receptor	Mus musculus	131-135
17257070-1	2006	PURPOSE: Antibodies targeting GD3 gangliosides highly expressed on melanomas mediate immune effector functions in vitro and inhibit animal model melanoma tumor growth in vivo.	Gangliosides	34-46	GRDX	Homo sapiens	30-33
16817235-0	2006	In vivo modulation of epidermal growth factor receptor phosphorylation in mice expressing different gangliosides.	Gangliosides	100-112	epidermal growth factor receptor	Mus musculus	22-54
16721824-6	2006	The Abeta oligomerization was accelerated by the application of lipid rafts isolated from ganglioside-rich cells, C2C12 cells, whereas this was not observed with the lipid rafts isolated from ganglioside-poor cells SK-N-MC and HeLa cells.	Gangliosides	90-101	amyloid beta (A4) precursor protein	Mus musculus	4-9
16817235-3	2006	Qualitative analysis of ganglioside composition in mice skin suggest that the increase of EGFr phosphorylation observed in skin from Sial-T2 knockout and Sial-T2/GalNAc-T double knockout mice in response to EGF might not be primary attributed to the expression of GD3 or a-series gangliosides in mice skin.	Gangliosides	24-35	epidermal growth factor receptor	Mus musculus	90-94
16817235-3	2006	Qualitative analysis of ganglioside composition in mice skin suggest that the increase of EGFr phosphorylation observed in skin from Sial-T2 knockout and Sial-T2/GalNAc-T double knockout mice in response to EGF might not be primary attributed to the expression of GD3 or a-series gangliosides in mice skin.	Gangliosides	280-292	epidermal growth factor receptor	Mus musculus	90-94
17079461-2	2006	We show that gangliosides, which are actively shed by tumor cells and bind to normal cells in the tumor microenvironment, have the potential to sensitize vascular endothelial cells to respond to subthreshold levels of VEGF: Ganglioside enrichment of human umbilical vein vascular endothelial cells (HUVEC) caused very low, normally barely stimulatory, VEGF concentrations to trigger robust VEGF receptor dimerization and autophosphorylation, as well as activation of downstream signaling pathways, and cell proliferation and migration.	Gangliosides	13-25	vascular endothelial growth factor A	Homo sapiens	218-222
17079461-2	2006	We show that gangliosides, which are actively shed by tumor cells and bind to normal cells in the tumor microenvironment, have the potential to sensitize vascular endothelial cells to respond to subthreshold levels of VEGF: Ganglioside enrichment of human umbilical vein vascular endothelial cells (HUVEC) caused very low, normally barely stimulatory, VEGF concentrations to trigger robust VEGF receptor dimerization and autophosphorylation, as well as activation of downstream signaling pathways, and cell proliferation and migration.	Gangliosides	13-25	vascular endothelial growth factor A	Homo sapiens	352-356
17079461-2	2006	We show that gangliosides, which are actively shed by tumor cells and bind to normal cells in the tumor microenvironment, have the potential to sensitize vascular endothelial cells to respond to subthreshold levels of VEGF: Ganglioside enrichment of human umbilical vein vascular endothelial cells (HUVEC) caused very low, normally barely stimulatory, VEGF concentrations to trigger robust VEGF receptor dimerization and autophosphorylation, as well as activation of downstream signaling pathways, and cell proliferation and migration.	Gangliosides	13-25	vascular endothelial growth factor A	Homo sapiens	352-356
17079461-2	2006	We show that gangliosides, which are actively shed by tumor cells and bind to normal cells in the tumor microenvironment, have the potential to sensitize vascular endothelial cells to respond to subthreshold levels of VEGF: Ganglioside enrichment of human umbilical vein vascular endothelial cells (HUVEC) caused very low, normally barely stimulatory, VEGF concentrations to trigger robust VEGF receptor dimerization and autophosphorylation, as well as activation of downstream signaling pathways, and cell proliferation and migration.	Gangliosides	224-235	vascular endothelial growth factor A	Homo sapiens	218-222
16962990-0	2006	Ganglioside GM2 modulates the erythrocyte Ca2+-ATPase through its binding to the calmodulin-binding domain and its "receptor".	Gangliosides	0-11	calmodulin 1	Homo sapiens	81-91
16962990-1	2006	We have previously demonstrated that gangliosides were able to modulate the plasma membrane Ca2+-ATPase (PMCA) from porcine brain synaptosomes and porcine erythrocytes [Y. Zhao, X.	Gangliosides	37-49	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	76-103
16826166-0	2006	Ganglioside GM3 promotes carcinoma cell proliferation via urokinase plasminogen activator-induced extracellular signal-regulated kinase-independent p70S6 kinase signaling.	Gangliosides	0-11	rolled	Drosophila melanogaster	98-135
16944201-1	2006	The S-adenosylhomocysteine hydrolase (SAH) and 14-3-3 zeta/phospholipase A2 (PLA2) are transcriptionally activated in parallel to the induction of the Epstein-Barr virus (EBV) lytic cycle by the ganglioside IV(3)NeuAc-nLcOse(4)Cer.	Gangliosides	195-206	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	47-58
16944201-1	2006	The S-adenosylhomocysteine hydrolase (SAH) and 14-3-3 zeta/phospholipase A2 (PLA2) are transcriptionally activated in parallel to the induction of the Epstein-Barr virus (EBV) lytic cycle by the ganglioside IV(3)NeuAc-nLcOse(4)Cer.	Gangliosides	195-206	phospholipase A2 group IIA	Homo sapiens	77-81
17185516-2	2006	Two main topics, that is, the roles of ganglioside GD3 in human malignant melanomas and those of GD2 in small cell lung cancer (SCLC) were reported.	Gangliosides	39-50	GRDX	Homo sapiens	51-54
16962990-13	2006	Taken together, our results suggested that gangliosides GD1b, GM1, GM2 (lower concentrations) and GM3 stimulated the PMCA by the interaction with calmodulin-binding domain, while the interaction of GM2 with the "receptor" of the calmodulin-binding domain of the enzyme led to the inhibition of the enzyme.	Gangliosides	43-55	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	117-121
16962990-13	2006	Taken together, our results suggested that gangliosides GD1b, GM1, GM2 (lower concentrations) and GM3 stimulated the PMCA by the interaction with calmodulin-binding domain, while the interaction of GM2 with the "receptor" of the calmodulin-binding domain of the enzyme led to the inhibition of the enzyme.	Gangliosides	43-55	calmodulin 1	Homo sapiens	146-156
16962990-13	2006	Taken together, our results suggested that gangliosides GD1b, GM1, GM2 (lower concentrations) and GM3 stimulated the PMCA by the interaction with calmodulin-binding domain, while the interaction of GM2 with the "receptor" of the calmodulin-binding domain of the enzyme led to the inhibition of the enzyme.	Gangliosides	43-55	calmodulin 1	Homo sapiens	229-239
16962990-1	2006	We have previously demonstrated that gangliosides were able to modulate the plasma membrane Ca2+-ATPase (PMCA) from porcine brain synaptosomes and porcine erythrocytes [Y. Zhao, X.	Gangliosides	37-49	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	105-109
16962990-9	2006	The results indicated that the PMCA from porcine erythrocytes responded to gangliosides was different from that from synaptosomes, suggesting that the effects of gangliosides on the PMCA are isoform specific.	Gangliosides	75-87	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	31-35
16721824-6	2006	The Abeta oligomerization was accelerated by the application of lipid rafts isolated from ganglioside-rich cells, C2C12 cells, whereas this was not observed with the lipid rafts isolated from ganglioside-poor cells SK-N-MC and HeLa cells.	Gangliosides	192-203	amyloid beta (A4) precursor protein	Mus musculus	4-9
16962990-9	2006	The results indicated that the PMCA from porcine erythrocytes responded to gangliosides was different from that from synaptosomes, suggesting that the effects of gangliosides on the PMCA are isoform specific.	Gangliosides	75-87	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	182-186
16962990-9	2006	The results indicated that the PMCA from porcine erythrocytes responded to gangliosides was different from that from synaptosomes, suggesting that the effects of gangliosides on the PMCA are isoform specific.	Gangliosides	162-174	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	31-35
16721824-7	2006	In addition, lipid raft-induced Abeta oligomerization was shown to be inhibited in CHO-K1 cells which were defective with regard to ganglioside biosynthesis.	Gangliosides	132-143	amyloid beta precursor protein	Homo sapiens	32-37
16962990-9	2006	The results indicated that the PMCA from porcine erythrocytes responded to gangliosides was different from that from synaptosomes, suggesting that the effects of gangliosides on the PMCA are isoform specific.	Gangliosides	162-174	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	182-186
16721824-8	2006	This indicates that Abeta oligomerization requires gangliosides that are enriched in the lipid rafts.	Gangliosides	51-63	amyloid beta precursor protein	Homo sapiens	20-25
16850162-3	2006	Diverse signaling molecules including reactive oxygen species, ceramide, and ganglioside GD3 can mediate apoptosis induction by fenretinide in transformed, premalignant, and malignant cells.	Gangliosides	77-88	GRDX	Homo sapiens	89-92
16797010-1	2006	Niemann-Pick C (NPC) disease is a progressive neurological disorder in which cholesterol, gangliosides and bis-monoacylglycerol phosphate accumulate in late endosomes/lysosomes.	Gangliosides	90-102	NPC intracellular cholesterol transporter 1	Homo sapiens	0-14
16797010-1	2006	Niemann-Pick C (NPC) disease is a progressive neurological disorder in which cholesterol, gangliosides and bis-monoacylglycerol phosphate accumulate in late endosomes/lysosomes.	Gangliosides	90-102	NPC intracellular cholesterol transporter 1	Homo sapiens	16-19
16911584-3	2006	Ganglioside distribution was altered in CT-2A tumor cells using an antisense construct to beta-1,4-N-acetylgalactosaminyltransferase (GalNAc-T), a key enzyme that uses the simple ganglioside GM3 as a substrate for the synthesis of the more complex gangliosides, GM2, GM1 and GD1a.	Gangliosides	0-11	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	134-142
16995997-0	2006	[Ganglioside GD3 enhances the anti-tumor effect of doxorubicin on hepatoma cells].	Gangliosides	1-12	GRDX	Homo sapiens	13-16
16857734-2	2006	Its sialic acid-binding activity on NK cells is masked by cis interactions with sialylated glycans, which are likely to be important for regulating the inhibitory function of Siglec-7, which exhibits an unusual preference for alpha2,8-linked disialic acids, a motif found in "b-series" gangliosides and some glycoproteins.	Gangliosides	286-298	sialic acid binding Ig like lectin 7	Homo sapiens	175-183
16847058-2	2006	Overexpression of recombinant GNE in human embryonic kidney (HEK AD293) cells led to an increase in mRNA levels for ST3Gal5 (GM3 synthase) and ST8Sia1 (GD3 synthase) as well as the biosynthetic products of these sialyltransferases, the GM3 and GD3 gangliosides.	Gangliosides	248-260	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	30-33
16847058-4	2006	Control experiments ensured that GNE-mediated changes in sialyltransferase expression and ganglioside biosynthesis were not the result of altered flux through the sialic acid pathway.	Gangliosides	90-101	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	33-36
16847058-5	2006	Interestingly, exogenous GM3 and GD3 also changed the expression of GNE and led to reduced ST3Gal5 and ST8Sia1 mRNA levels, demonstrating a reciprocating feedback mechanism where gangliosides regulate upstream biosynthetic enzymes.	Gangliosides	179-191	GRDX	Homo sapiens	33-36
16847058-5	2006	Interestingly, exogenous GM3 and GD3 also changed the expression of GNE and led to reduced ST3Gal5 and ST8Sia1 mRNA levels, demonstrating a reciprocating feedback mechanism where gangliosides regulate upstream biosynthetic enzymes.	Gangliosides	179-191	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	Homo sapiens	68-71
16847058-5	2006	Interestingly, exogenous GM3 and GD3 also changed the expression of GNE and led to reduced ST3Gal5 and ST8Sia1 mRNA levels, demonstrating a reciprocating feedback mechanism where gangliosides regulate upstream biosynthetic enzymes.	Gangliosides	179-191	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	91-98
16847058-5	2006	Interestingly, exogenous GM3 and GD3 also changed the expression of GNE and led to reduced ST3Gal5 and ST8Sia1 mRNA levels, demonstrating a reciprocating feedback mechanism where gangliosides regulate upstream biosynthetic enzymes.	Gangliosides	179-191	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	103-110
25792782-1	2006	Gangliosides in the brain of the knockout mouse deficient in the activity of beta1,4 N-acetylgalactosaminyl transferase (beta1,4 GalNAc-T)(GM2 synthase) consisted of nearly exclusively of GM3- and GD3-gangliosides as expected from the known substrate specificity of the enzyme and in confirmation of the initial reports from two laboratories that generated the mutant mouse experimentally.	Gangliosides	0-12	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	77-119
25792782-1	2006	Gangliosides in the brain of the knockout mouse deficient in the activity of beta1,4 N-acetylgalactosaminyl transferase (beta1,4 GalNAc-T)(GM2 synthase) consisted of nearly exclusively of GM3- and GD3-gangliosides as expected from the known substrate specificity of the enzyme and in confirmation of the initial reports from two laboratories that generated the mutant mouse experimentally.	Gangliosides	0-12	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	121-137
25792782-1	2006	Gangliosides in the brain of the knockout mouse deficient in the activity of beta1,4 N-acetylgalactosaminyl transferase (beta1,4 GalNAc-T)(GM2 synthase) consisted of nearly exclusively of GM3- and GD3-gangliosides as expected from the known substrate specificity of the enzyme and in confirmation of the initial reports from two laboratories that generated the mutant mouse experimentally.	Gangliosides	0-12	cytochrome b5 domain containing 2	Mus musculus	139-142
25792782-1	2006	Gangliosides in the brain of the knockout mouse deficient in the activity of beta1,4 N-acetylgalactosaminyl transferase (beta1,4 GalNAc-T)(GM2 synthase) consisted of nearly exclusively of GM3- and GD3-gangliosides as expected from the known substrate specificity of the enzyme and in confirmation of the initial reports from two laboratories that generated the mutant mouse experimentally.	Gangliosides	0-12	granulocyte macrophage antigen 3	Mus musculus	188-191
16911584-3	2006	Ganglioside distribution was altered in CT-2A tumor cells using an antisense construct to beta-1,4-N-acetylgalactosaminyltransferase (GalNAc-T), a key enzyme that uses the simple ganglioside GM3 as a substrate for the synthesis of the more complex gangliosides, GM2, GM1 and GD1a.	Gangliosides	179-190	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	134-142
16911584-3	2006	Ganglioside distribution was altered in CT-2A tumor cells using an antisense construct to beta-1,4-N-acetylgalactosaminyltransferase (GalNAc-T), a key enzyme that uses the simple ganglioside GM3 as a substrate for the synthesis of the more complex gangliosides, GM2, GM1 and GD1a.	Gangliosides	248-260	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	134-142
16718701-7	2006	The delivery of IDUA to large areas, which could encompass the entire brain, prevented glycosaminoglycan and secondary ganglioside accumulations.	Gangliosides	119-130	alpha-L-iduronidase	Canis lupus familiaris	16-20
16580208-1	2006	The tetrasaccharide substructure 1 of the ganglioside GQ1balpha shows a remarkable affinity for the myelin-associated glycoprotein (MAG).	Gangliosides	42-53	myelin associated glycoprotein	Homo sapiens	100-130
16880599-4	2006	We have found a selective increase in the acidic glycosphingolipid ganglioside GM3 in 3T3-L1 adipocytes treated with TNFalpha, suggesting a specific function for GM3.	Gangliosides	67-78	tumor necrosis factor	Rattus norvegicus	117-125
16866986-9	2006	These data were further corroborated by a data analysis from one of our previous studies on gangliosides of 80 GBMs, in which increased amounts of GM3 and GD3 (which accumulate in the absence of GalNAcT) correlated with a longer survival (P < 0.01).	Gangliosides	92-104	GRDX	Homo sapiens	155-158
16580208-1	2006	The tetrasaccharide substructure 1 of the ganglioside GQ1balpha shows a remarkable affinity for the myelin-associated glycoprotein (MAG).	Gangliosides	42-53	myelin associated glycoprotein	Homo sapiens	132-135
16623661-4	2006	As a first step towards this end, we present the crystal structure of siglec-7 in complex with a sialylated ligand, the ganglioside analogue DSLc4 [alpha(2,3)/alpha(2,6) disialyl lactotetraosyl 2-(trimethylsilyl)ethyl], which allows for a detailed description of the binding site, required for structure-guided inhibitor design.	Gangliosides	120-131	sialic acid binding Ig like lectin 7	Homo sapiens	70-78
16236485-7	2006	Lipid rafts undergo changes in their lipid composition (ganglioside M1, cholesterol) in CD4+ and CD8+ T cells of elderly individuals.	Gangliosides	56-67	CD4 molecule	Homo sapiens	88-91
16818659-4	2006	The RCC tissue-derived gangliosides also suppressed IFN-gamma and, in many cases, interleukin-4 production by CD4+ T cells at concentrations (1 ng/mL-100 pg/mL) well below those that induce any detectable T-cell death (4-20 microg/mL).	Gangliosides	23-35	interferon gamma	Homo sapiens	52-61
16818659-4	2006	The RCC tissue-derived gangliosides also suppressed IFN-gamma and, in many cases, interleukin-4 production by CD4+ T cells at concentrations (1 ng/mL-100 pg/mL) well below those that induce any detectable T-cell death (4-20 microg/mL).	Gangliosides	23-35	interleukin 4	Homo sapiens	82-95
16818659-8	2006	DMF10.167.4 also partially blocked the suppression of IFN-gamma production induced by RCC tissue-derived gangliosides, suggesting that GM2 plays a role in down-regulating cytokine production by CD4+ T cells.	Gangliosides	105-117	interferon gamma	Homo sapiens	54-63
16897174-0	2006	Ganglioside GD1a regulation of caveolin-1 and Stim1 expression in mouse FBJ cells: augmented expression of caveolin-1 and Stim1 in cells with increased GD1a content.	Gangliosides	0-11	caveolin 1, caveolae protein	Mus musculus	31-41
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	phosphatase and tensin homolog	Homo sapiens	32-36
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	tumor protein p53	Homo sapiens	100-103
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	cyclin dependent kinase inhibitor 1A	Homo sapiens	114-117
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	cyclin dependent kinase inhibitor 1A	Homo sapiens	118-122
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	tumor protein p53	Homo sapiens	128-131
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	interferon alpha inducible protein 27	Homo sapiens	144-147
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	cyclin dependent kinase inhibitor 1B	Homo sapiens	148-152
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	phosphatase and tensin homolog	Homo sapiens	189-193
16574813-8	2006	On the contrary, suppression of PTEN levels by RNA interference restores the enhanced expression of p53-dependent p21(WAF1) and p53-independent p27(kip1) through inactivating the effect of PTEN on PI-3K/AKT signaling modulated by ganglioside GM3.	Gangliosides	230-241	AKT serine/threonine kinase 1	Homo sapiens	203-206
16574813-9	2006	These results suggest that ganglioside GM3-stimulated PTEN expression modulates cell cycle regulatory proteins, thus inhibiting cell growth.	Gangliosides	27-38	phosphatase and tensin homolog	Homo sapiens	54-58
16574813-0	2006	Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.	Gangliosides	0-11	phosphatase and tensin homolog	Homo sapiens	43-47
16574813-0	2006	Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.	Gangliosides	0-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-113
16574813-0	2006	Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.	Gangliosides	0-11	cyclin dependent kinase inhibitor 1A	Homo sapiens	114-118
16574813-0	2006	Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.	Gangliosides	0-11	interferon alpha inducible protein 27	Homo sapiens	124-127
16574813-0	2006	Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.	Gangliosides	0-11	cyclin dependent kinase inhibitor 1B	Homo sapiens	128-132
16574813-0	2006	Ganglioside GM3 modulates tumor suppressor PTEN-mediated cell cycle progression--transcriptional induction of p21(WAF1) and p27(kip1) by inhibition of PI-3K/AKT pathway.	Gangliosides	0-11	AKT serine/threonine kinase 1	Homo sapiens	157-160
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	tumor protein p53	Homo sapiens	68-71
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	110-113
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	114-118
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-144
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	145-149
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-144
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	cyclin dependent kinase inhibitor 1A	Homo sapiens	145-149
16574813-5	2006	Moreover, the data herein clearly show that ganglioside GM3 induces p53-dependent transcriptional activity of p21(WAF1), as evidenced by the p21(WAF1) promoter-driven luciferase reporter plasmid (full-length p21(WAF1) promoter and a construct lacking the p53-binding sites).	Gangliosides	44-55	tumor protein p53	Homo sapiens	255-258
16897174-0	2006	Ganglioside GD1a regulation of caveolin-1 and Stim1 expression in mouse FBJ cells: augmented expression of caveolin-1 and Stim1 in cells with increased GD1a content.	Gangliosides	0-11	stromal interaction molecule 1	Mus musculus	46-51
16897174-0	2006	Ganglioside GD1a regulation of caveolin-1 and Stim1 expression in mouse FBJ cells: augmented expression of caveolin-1 and Stim1 in cells with increased GD1a content.	Gangliosides	0-11	caveolin 1, caveolae protein	Mus musculus	107-117
16897174-0	2006	Ganglioside GD1a regulation of caveolin-1 and Stim1 expression in mouse FBJ cells: augmented expression of caveolin-1 and Stim1 in cells with increased GD1a content.	Gangliosides	0-11	stromal interaction molecule 1	Mus musculus	122-127
16631599-6	2006	LA is in a unique category of compounds that induce CD4 downmodulation by various mechanisms (e.g., gangliosides).	Gangliosides	100-112	CD4 molecule	Homo sapiens	52-55
16491123-0	2006	Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1.	Gangliosides	0-11	mitogen-activated protein kinase 1	Mus musculus	54-58
16491123-0	2006	Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1.	Gangliosides	0-11	kayak	Drosophila melanogaster	63-68
16491123-0	2006	Ganglioside GM3 promotes cell migration by regulating MAPK and c-Fos/AP-1.	Gangliosides	0-11	kayak	Drosophila melanogaster	69-73
16636105-0	2006	Ganglioside GM3 is involved in neuronal cell death.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
16636105-4	2006	In this study, we report that ganglioside GM3 is involved in neuronal cell death.	Gangliosides	30-41	granulocyte macrophage antigen 3	Mus musculus	42-45
16547352-1	2006	Previous studies have indicated a role for glucosylceramide synthase (GCS) in multidrug resistance (MDR), either related to turnover of ceramide (Cer) or generation of gangliosides, which modulate apoptosis and/or the activity of ABC transporters.	Gangliosides	168-180	UDP-glucose ceramide glucosyltransferase	Homo sapiens	43-68
16675488-4	2006	We showed that both gangliosides impaired spontaneous LC maturation induced by a short in vitro culture, as assessed by significant down-regulation of co-stimulation (CD40, CD54, CD80, CD86) and maturation markers (CD83, CCR7), which correlated to an impaired ability of the cells to mount allogeneic T cell proliferation.	Gangliosides	20-32	CD40 molecule	Homo sapiens	167-171
16675488-4	2006	We showed that both gangliosides impaired spontaneous LC maturation induced by a short in vitro culture, as assessed by significant down-regulation of co-stimulation (CD40, CD54, CD80, CD86) and maturation markers (CD83, CCR7), which correlated to an impaired ability of the cells to mount allogeneic T cell proliferation.	Gangliosides	20-32	intercellular adhesion molecule 1	Homo sapiens	173-177
16675488-4	2006	We showed that both gangliosides impaired spontaneous LC maturation induced by a short in vitro culture, as assessed by significant down-regulation of co-stimulation (CD40, CD54, CD80, CD86) and maturation markers (CD83, CCR7), which correlated to an impaired ability of the cells to mount allogeneic T cell proliferation.	Gangliosides	20-32	CD80 molecule	Homo sapiens	179-183
16675488-4	2006	We showed that both gangliosides impaired spontaneous LC maturation induced by a short in vitro culture, as assessed by significant down-regulation of co-stimulation (CD40, CD54, CD80, CD86) and maturation markers (CD83, CCR7), which correlated to an impaired ability of the cells to mount allogeneic T cell proliferation.	Gangliosides	20-32	CD86 molecule	Homo sapiens	185-189
16675488-4	2006	We showed that both gangliosides impaired spontaneous LC maturation induced by a short in vitro culture, as assessed by significant down-regulation of co-stimulation (CD40, CD54, CD80, CD86) and maturation markers (CD83, CCR7), which correlated to an impaired ability of the cells to mount allogeneic T cell proliferation.	Gangliosides	20-32	CD83 molecule	Homo sapiens	215-219
16675488-4	2006	We showed that both gangliosides impaired spontaneous LC maturation induced by a short in vitro culture, as assessed by significant down-regulation of co-stimulation (CD40, CD54, CD80, CD86) and maturation markers (CD83, CCR7), which correlated to an impaired ability of the cells to mount allogeneic T cell proliferation.	Gangliosides	20-32	C-C motif chemokine receptor 7	Homo sapiens	221-225
16675488-5	2006	Furthermore, the ganglioside-treated cells displayed less ability to migrate towards CCL19/macrophage inflammatory protein 3 beta, the chemokine that specifically binds CCR7 and mediates LC migration to lymph nodes.	Gangliosides	17-28	C-C motif chemokine ligand 19	Homo sapiens	85-90
16675488-5	2006	Furthermore, the ganglioside-treated cells displayed less ability to migrate towards CCL19/macrophage inflammatory protein 3 beta, the chemokine that specifically binds CCR7 and mediates LC migration to lymph nodes.	Gangliosides	17-28	C-C motif chemokine ligand 19	Homo sapiens	91-129
16675488-5	2006	Furthermore, the ganglioside-treated cells displayed less ability to migrate towards CCL19/macrophage inflammatory protein 3 beta, the chemokine that specifically binds CCR7 and mediates LC migration to lymph nodes.	Gangliosides	17-28	C-C motif chemokine receptor 7	Homo sapiens	169-173
16547352-1	2006	Previous studies have indicated a role for glucosylceramide synthase (GCS) in multidrug resistance (MDR), either related to turnover of ceramide (Cer) or generation of gangliosides, which modulate apoptosis and/or the activity of ABC transporters.	Gangliosides	168-180	UDP-glucose ceramide glucosyltransferase	Homo sapiens	70-73
16547352-3	2006	Two inhibitors of GCS, D,L-threo-1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol (t-PPPP) and N-butyldeoxynojirimycin (NB-dNJ), very efficiently depleted ganglioside content in two human neuroblastoma cell lines.	Gangliosides	160-171	UDP-glucose ceramide glucosyltransferase	Homo sapiens	18-21
16547352-5	2006	Fluorescence-activated cell sorting (FACS) analysis showed that ganglioside depletion only slightly and in the opposite direction affected Pgp- and MRP1-mediated efflux activity.	Gangliosides	64-75	ATP binding cassette subfamily B member 1	Homo sapiens	139-142
16547352-5	2006	Fluorescence-activated cell sorting (FACS) analysis showed that ganglioside depletion only slightly and in the opposite direction affected Pgp- and MRP1-mediated efflux activity.	Gangliosides	64-75	ATP binding cassette subfamily C member 1	Homo sapiens	148-152
16814200-5	2006	Finally, glycosphingolipids such as gangliosides occur in the NE where GM1, one member of the gangliotetraose family, influences Ca(2+) flux by activation of a Na(+)/Ca(2+) exchanger located in the inner membrane of the NE.	Gangliosides	36-48	coenzyme Q10A	Mus musculus	71-74
16452464-1	2006	The organization of membrane subdomains in mammalian sperm has recently generated controversy, with several reports describing widely differing localization patterns for the ganglioside GM1.	Gangliosides	174-185	coenzyme Q10A	Mus musculus	186-189
16651628-0	2006	Gangliosides trigger inflammatory responses via TLR4 in brain glia.	Gangliosides	0-12	toll like receptor 4	Homo sapiens	48-52
16651628-3	2006	Here we report that toll-like receptor 4 (TLR4) may mediate the ganglioside-triggered inflammation in glia, brain resident immune cells.	Gangliosides	64-75	toll like receptor 4	Homo sapiens	20-40
16651628-3	2006	Here we report that toll-like receptor 4 (TLR4) may mediate the ganglioside-triggered inflammation in glia, brain resident immune cells.	Gangliosides	64-75	toll like receptor 4	Homo sapiens	42-46
16651628-4	2006	Gangliosides rapidly altered the cell surface expression of TLR4 in microglia and astrocytes within 3 hours.	Gangliosides	0-12	toll like receptor 4	Homo sapiens	60-64
16651628-5	2006	Using TLR4-specific siRNA and a dominant-negative TLR4 gene, we clearly demonstrate the functional importance of TLR4 in ganglioside-triggered activation of glia.	Gangliosides	121-132	toll like receptor 4	Homo sapiens	6-10
16651628-5	2006	Using TLR4-specific siRNA and a dominant-negative TLR4 gene, we clearly demonstrate the functional importance of TLR4 in ganglioside-triggered activation of glia.	Gangliosides	121-132	toll like receptor 4	Homo sapiens	50-54
16651628-5	2006	Using TLR4-specific siRNA and a dominant-negative TLR4 gene, we clearly demonstrate the functional importance of TLR4 in ganglioside-triggered activation of glia.	Gangliosides	121-132	toll like receptor 4	Homo sapiens	50-54
16651628-6	2006	Inhibition of TLR4 expression by TLR4-siRNA suppressed nuclear factor (NF)-kappaB-binding activity, NF-kappaB-dependent luciferase activity, and transcription of inflammatory cytokines after exposure to gangliosides.	Gangliosides	203-215	toll like receptor 4	Homo sapiens	14-18
16651628-6	2006	Inhibition of TLR4 expression by TLR4-siRNA suppressed nuclear factor (NF)-kappaB-binding activity, NF-kappaB-dependent luciferase activity, and transcription of inflammatory cytokines after exposure to gangliosides.	Gangliosides	203-215	toll like receptor 4	Homo sapiens	33-37
16651628-9	2006	In addition, CD14 was required for ganglioside-triggered activation of glia, and lipid raft formation may be associated with ganglioside-stimulated signal propagation.	Gangliosides	35-46	CD14 molecule	Homo sapiens	13-17
16651628-10	2006	Taken together, these results suggest that TLR4 may provide an explanation for the pathological ability of gangliosides to cause inflammatory conditions in the brain.	Gangliosides	107-119	toll like receptor 4	Homo sapiens	43-47
16898583-2	2006	To investigate their role in tumor formation and angiogenesis, we sought to develop an inhibitory model targeting human GM3 synthase, an essential enzyme in the ganglioside synthesis pathway, by antisense transfection.	Gangliosides	161-172	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	120-132
16623716-3	2006	In addition, analysis of membrane fractions obtained using a linear sucrose gradient showed that ErbB2, epidermal growth factor receptor (EGFR) and Shc-p66 (proteins correlated with the ErbB2 signal transduction pathway) were preferentially enriched in lipid rafts together with gangliosides.	Gangliosides	279-291	erb-b2 receptor tyrosine kinase 2	Homo sapiens	97-102
16515539-0	2006	Lipocalin-type prostaglandin D synthase is up-regulated in oligodendrocytes in lysosomal storage diseases and binds gangliosides.	Gangliosides	116-128	prostaglandin D2 synthase (brain)	Mus musculus	0-39
16507579-3	2006	Based on our previous finding that in cultured rat brain microglia, gangliosides induce rapid and transient activation of the JAK-STAT pathway, we hypothesized that raft-mediated SHP-2 activation is involved in transient activation of JAK-STAT signaling by gangliosides.	Gangliosides	68-80	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	179-184
16507579-3	2006	Based on our previous finding that in cultured rat brain microglia, gangliosides induce rapid and transient activation of the JAK-STAT pathway, we hypothesized that raft-mediated SHP-2 activation is involved in transient activation of JAK-STAT signaling by gangliosides.	Gangliosides	257-269	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	179-184
16507579-4	2006	We first used Western blot analysis to confirm that gangliosides rapidly induce the phosphorylation of SHP-2.	Gangliosides	52-64	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	103-108
16507579-6	2006	Immunostaining using antibodies directed against p-SHP-2 and flotillin-1 revealed ganglioside-induced clustering and polarization of p-SHP-2 in membrane rafts.	Gangliosides	82-93	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	51-56
16507579-6	2006	Immunostaining using antibodies directed against p-SHP-2 and flotillin-1 revealed ganglioside-induced clustering and polarization of p-SHP-2 in membrane rafts.	Gangliosides	82-93	flotillin 1	Rattus norvegicus	61-72
16507579-6	2006	Immunostaining using antibodies directed against p-SHP-2 and flotillin-1 revealed ganglioside-induced clustering and polarization of p-SHP-2 in membrane rafts.	Gangliosides	82-93	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	135-140
16507579-8	2006	Rapid SHP-2 recruitment to detergent-insoluble raft fractions by gangliosides was inhibited by filipin, further indicating the involvement of rafts.	Gangliosides	65-77	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	6-11
16507579-9	2006	We also confirmed by immunoprecipitation that SHP-2 rapidly binds in a raft-dependent manner to JAK2 in response to gangliosides.	Gangliosides	116-128	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	46-51
16507579-9	2006	We also confirmed by immunoprecipitation that SHP-2 rapidly binds in a raft-dependent manner to JAK2 in response to gangliosides.	Gangliosides	116-128	Janus kinase 2	Rattus norvegicus	96-100
16507579-10	2006	Our study therefore showed that transient activation of the JAK-STAT pathway by gangliosides is accomplished by SHP-2 in a raft-dependent manner in brain microglia.	Gangliosides	80-92	protein tyrosine phosphatase, non-receptor type 11	Rattus norvegicus	112-117
16623710-6	2006	In this study, we characterized in both GD3 ganglioside-expressing Chinese hamster ovary (CHO)-K1 and SK-Mel 28 melanoma cells the intracellular trafficking and subcellular localization of the mouse monoclonal antibody to GD3, R24.	Gangliosides	44-55	GRDX	Homo sapiens	40-43
16623716-0	2006	Role of gangliosides in the association of ErbB2 with lipid rafts in mammary epithelial HC11 cells.	Gangliosides	8-20	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-48
16623716-1	2006	We analyzed the role of gangliosides in the association of the ErbB2 receptor tyrosine-kinase (RTK) with lipid rafts in mammary epithelial HC11 cells.	Gangliosides	24-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	63-68
16682820-3	2006	Ganglioside GM1 exists in abundance on the surface of the M cells of Peyer"s patch, a well-known mucosal immunity induction site.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-15
16208470-6	2006	The CD4 complete recovery in these cells occurred after 48 h of ganglioside removal, due to neo-synthesis.	Gangliosides	64-75	CD4 molecule	Homo sapiens	4-7
16208470-7	2006	Restored T cells kept similar sensitivity to ganglioside-induced CD4 down-modulation after a new challenge.	Gangliosides	45-56	CD4 molecule	Homo sapiens	65-68
16623716-3	2006	In addition, analysis of membrane fractions obtained using a linear sucrose gradient showed that ErbB2, epidermal growth factor receptor (EGFR) and Shc-p66 (proteins correlated with the ErbB2 signal transduction pathway) were preferentially enriched in lipid rafts together with gangliosides.	Gangliosides	279-291	epidermal growth factor receptor	Homo sapiens	104-136
16623716-3	2006	In addition, analysis of membrane fractions obtained using a linear sucrose gradient showed that ErbB2, epidermal growth factor receptor (EGFR) and Shc-p66 (proteins correlated with the ErbB2 signal transduction pathway) were preferentially enriched in lipid rafts together with gangliosides.	Gangliosides	279-291	erb-b2 receptor tyrosine kinase 2	Homo sapiens	186-191
16623716-4	2006	Blocking of endogenous ganglioside synthesis by (+/-)-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride ([D]-PDMP) induced a drastic cell-surface redistribution of ErbB2, EGFR and Shc-p66, within the Triton-soluble fractions, as revealed by linear sucrose-gradient analysis.	Gangliosides	23-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	183-188
16623716-4	2006	Blocking of endogenous ganglioside synthesis by (+/-)-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol hydrochloride ([D]-PDMP) induced a drastic cell-surface redistribution of ErbB2, EGFR and Shc-p66, within the Triton-soluble fractions, as revealed by linear sucrose-gradient analysis.	Gangliosides	23-34	epidermal growth factor receptor	Homo sapiens	190-194
16623716-6	2006	The results point out the key role of ganglioside GM3 in retaining ErbB2 and signal-transduction-correlated proteins in lipid rafts.	Gangliosides	38-49	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-72
16428383-1	2006	Human plasma membrane-associated sialidase (NEU3), specifically hydrolyzing gangliosides, plays crucial roles in the regulation of cell surface functions.	Gangliosides	76-88	neuraminidase 3	Homo sapiens	13-48
16477650-2	2006	The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p65, and NFATc2 in the N13 murine microglial cell line.	Gangliosides	4-15	interleukin 15	Mus musculus	27-32
16477650-2	2006	The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p65, and NFATc2 in the N13 murine microglial cell line.	Gangliosides	4-15	interleukin 15	Mus musculus	97-102
16477650-2	2006	The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p65, and NFATc2 in the N13 murine microglial cell line.	Gangliosides	4-15	interleukin 15 receptor, alpha chain	Mus musculus	165-176
16477650-2	2006	The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p65, and NFATc2 in the N13 murine microglial cell line.	Gangliosides	4-15	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	178-181
16477650-2	2006	The ganglioside binding to IL-15 inhibited the proinflammatory effects of the cytokine, reducing IL-15-dependent T-cell proliferation as well as mRNA expression for IL-15Ralpha, p65, and NFATc2 in the N13 murine microglial cell line.	Gangliosides	4-15	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	Mus musculus	187-193
16497300-5	2006	Galectin-1 is a member of an adhesion/growth-regulatory family known to interact for example with ganglioside GM(1) and also the hydrophobic tail of oncogenic H-Ras.	Gangliosides	98-109	galectin 1	Homo sapiens	0-10
16241905-1	2006	We have found previously that human plasma-membrane-associated sialidase (NEU3), a key glycosidase for ganglioside degradation, was markedly up-regulated in human colon cancers, with an involvement in suppression of apoptosis.	Gangliosides	103-114	neuraminidase 3	Homo sapiens	74-78
16393952-3	2006	We report that in human T cells, CD28, CD59, and CD55 are all localized into lipid rafts and that CD28 is concentrated into microdomains enriched in ganglioside GM1, whereas CD59 and CD55 are not.	Gangliosides	149-160	CD28 molecule	Homo sapiens	98-102
16458892-0	2006	GD3-replica peptides selected from a phage peptide library induce a GD3 ganglioside antibody response.	Gangliosides	72-83	GRDX	Homo sapiens	0-3
16458892-0	2006	GD3-replica peptides selected from a phage peptide library induce a GD3 ganglioside antibody response.	Gangliosides	72-83	GRDX	Homo sapiens	68-71
16444586-5	2006	Among the acidic sphingolipids, SCP-2 resulted in a 5.2-fold decrease in the endogenous plasma membrane level of ganglioside GM1 (p < 0.03).	Gangliosides	113-124	sterol carrier protein 2, liver	Mus musculus	32-37
16261579-2	2006	Our results suggest that CD38 is likely to recognize the two phosphate groups in NAD and the two carboxyl groups in tandem sialic acid residues of gangliosides.	Gangliosides	147-159	CD38 molecule	Homo sapiens	25-29
16478472-1	2006	The GM2-activator protein (GM2AP) is an essential cofactor for the lysosomal degradation of ganglioside GM2 by beta-hexosaminidase A (HexA).	Gangliosides	92-103	ganglioside GM2 activator	Homo sapiens	4-25
16478472-1	2006	The GM2-activator protein (GM2AP) is an essential cofactor for the lysosomal degradation of ganglioside GM2 by beta-hexosaminidase A (HexA).	Gangliosides	92-103	ganglioside GM2 activator	Homo sapiens	27-32
16478472-1	2006	The GM2-activator protein (GM2AP) is an essential cofactor for the lysosomal degradation of ganglioside GM2 by beta-hexosaminidase A (HexA).	Gangliosides	92-103	hexosaminidase subunit alpha	Homo sapiens	111-132
16478472-1	2006	The GM2-activator protein (GM2AP) is an essential cofactor for the lysosomal degradation of ganglioside GM2 by beta-hexosaminidase A (HexA).	Gangliosides	92-103	hexosaminidase subunit alpha	Homo sapiens	134-138
16415169-5	2006	The presence of gangliosides during T cell activation reduced the expression of interferon-gamma (IFN-gamma) and enhanced that of interleukin (IL)-4, suggesting a shift toward a type-2 response.	Gangliosides	16-28	interferon gamma	Mus musculus	80-96
16415169-5	2006	The presence of gangliosides during T cell activation reduced the expression of interferon-gamma (IFN-gamma) and enhanced that of interleukin (IL)-4, suggesting a shift toward a type-2 response.	Gangliosides	16-28	interferon gamma	Mus musculus	98-107
16415169-5	2006	The presence of gangliosides during T cell activation reduced the expression of interferon-gamma (IFN-gamma) and enhanced that of interleukin (IL)-4, suggesting a shift toward a type-2 response.	Gangliosides	16-28	interleukin 4	Mus musculus	130-148
16415169-6	2006	Intracellular cytokine staining demonstrated that gangliosides inhibited IFN-gamma production in CD4+, CD8+, and natural killer (NK)1.1+ cell populations and enhanced IL-4 in CD4+ T cells.	Gangliosides	50-62	interferon gamma	Mus musculus	73-82
16415169-6	2006	Intracellular cytokine staining demonstrated that gangliosides inhibited IFN-gamma production in CD4+, CD8+, and natural killer (NK)1.1+ cell populations and enhanced IL-4 in CD4+ T cells.	Gangliosides	50-62	interleukin 4	Mus musculus	167-171
16415169-7	2006	The ganglioside-mediated enhancement in IL-4 production was independent of changes in endogenous IFN-gamma, did not occur with cells from CD1d-deficient mice, and was partially inhibited by anti-CD1d antibodies.	Gangliosides	4-15	interleukin 4	Mus musculus	40-44
16415169-7	2006	The ganglioside-mediated enhancement in IL-4 production was independent of changes in endogenous IFN-gamma, did not occur with cells from CD1d-deficient mice, and was partially inhibited by anti-CD1d antibodies.	Gangliosides	4-15	interferon gamma	Mus musculus	97-106
16415169-7	2006	The ganglioside-mediated enhancement in IL-4 production was independent of changes in endogenous IFN-gamma, did not occur with cells from CD1d-deficient mice, and was partially inhibited by anti-CD1d antibodies.	Gangliosides	4-15	CD1d1 antigen	Mus musculus	195-199
16866908-2	2006	Processing of amyloid precursor protein (APP) is sensitive to membrane alterations in levels of cholesterol and gangliosides.	Gangliosides	112-124	amyloid beta (A4) precursor protein	Mus musculus	14-39
16359123-5	2005	When B16LuF10 cell gangliosides were used in combination with fibronectin, gangliosides removed the migration inhibitory effect of fibronectin resulting in net enhancing effect.	Gangliosides	19-31	fibronectin 1	Mus musculus	131-142
16214265-8	2006	Thus, our studies clearly show that chronic ethanol induced deglycosylation of brain gangliosides is in part, due to specific up-regulation of plasma membrane sialidase in the myelin and synaptosomal membrane fractions of the brain.	Gangliosides	85-97	neuraminidase 3	Rattus norvegicus	150-168
16214265-9	2006	This increase in plasma membrane sialidase may be responsible for chronic-ethanol-induced physiological and neurological impairment in the brain, presumably due to deglycosylation of gangliosides that are essential for crucial cellular and metabolic activities.	Gangliosides	183-195	neuraminidase 3	Rattus norvegicus	24-42
16256935-0	2005	Gangliosides activate the phosphatase activity of the erythrocyte plasma membrane Ca2+-ATPase.	Gangliosides	0-12	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	66-93
17094170-0	2006	A liquid chromatography/tandem mass spectrometric approach for the determination of gangliosides GD3 and GM3 in bovine milk and infant formulae.	Gangliosides	84-96	GRDX	Homo sapiens	97-100
16359123-0	2005	Gangliosides enhance migration of mouse B16-melanoma cells through artificial basement membrane alone or in presence of laminin or fibronectin.	Gangliosides	0-12	fibronectin 1	Mus musculus	131-142
16359123-5	2005	When B16LuF10 cell gangliosides were used in combination with fibronectin, gangliosides removed the migration inhibitory effect of fibronectin resulting in net enhancing effect.	Gangliosides	75-87	fibronectin 1	Mus musculus	62-73
16359123-3	2005	Moreover, B16LuF10 cell gangliosides modified the migratory effect of laminin and fibronectin on B16LuF1 cells.	Gangliosides	24-36	fibronectin 1	Mus musculus	82-93
16359123-5	2005	When B16LuF10 cell gangliosides were used in combination with fibronectin, gangliosides removed the migration inhibitory effect of fibronectin resulting in net enhancing effect.	Gangliosides	75-87	fibronectin 1	Mus musculus	131-142
16216074-1	2005	GM2-activator protein (GM2AP) is a lysosomal lipid transfer protein with important biological roles in ganglioside catabolism, phospholipid metabolism, and T-cell activation.	Gangliosides	103-114	GM2 ganglioside activator protein	Mus musculus	0-21
15907365-3	2005	Downstream of ceramide, apoptosis in response to fenretinide is mediated by increased glucosylceramide synthase activity resulting in increased levels of gangliosides GD3 and GD2 via GD3 synthase.	Gangliosides	154-166	UDP-glucose ceramide glucosyltransferase	Homo sapiens	86-111
16118364-0	2005	Mastoparan changes the cellular localization of Galphaq/11 and Gbeta through its binding to ganglioside in lipid rafts.	Gangliosides	92-103	G protein subunit alpha q	Rattus norvegicus	48-55
15907365-3	2005	Downstream of ceramide, apoptosis in response to fenretinide is mediated by increased glucosylceramide synthase activity resulting in increased levels of gangliosides GD3 and GD2 via GD3 synthase.	Gangliosides	154-166	GRDX	Homo sapiens	167-170
15907365-3	2005	Downstream of ceramide, apoptosis in response to fenretinide is mediated by increased glucosylceramide synthase activity resulting in increased levels of gangliosides GD3 and GD2 via GD3 synthase.	Gangliosides	154-166	GRDX	Homo sapiens	183-186
16216074-1	2005	GM2-activator protein (GM2AP) is a lysosomal lipid transfer protein with important biological roles in ganglioside catabolism, phospholipid metabolism, and T-cell activation.	Gangliosides	103-114	GM2 ganglioside activator protein	Mus musculus	23-28
16210594-0	2005	Modulation of CD4 Th cell differentiation by ganglioside GD1a in vitro.	Gangliosides	45-56	CD4 molecule	Homo sapiens	14-17
16150545-4	2005	To clarify the function of b- and c-series gangliosides in pain sensation in vivo, we generated mice in whom the gene for the alpha-2,8-sialyltransferase (GD3 synthase), which is responsible for the generation of all b-series gangliosides as well as c-series gangliosides, was disrupted.	Gangliosides	43-55	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	126-153
15917432-12	2005	Dietary gangliosides decrease the cholesterol/ganglioside ratio, caveolin, PAF and DG content in microdomains thus exerting a potential anti-inflammatory effect during gut development.	Gangliosides	8-20	PCNA clamp associated factor	Rattus norvegicus	75-85
15917432-12	2005	Dietary gangliosides decrease the cholesterol/ganglioside ratio, caveolin, PAF and DG content in microdomains thus exerting a potential anti-inflammatory effect during gut development.	Gangliosides	8-19	PCNA clamp associated factor	Rattus norvegicus	75-85
16150545-4	2005	To clarify the function of b- and c-series gangliosides in pain sensation in vivo, we generated mice in whom the gene for the alpha-2,8-sialyltransferase (GD3 synthase), which is responsible for the generation of all b-series gangliosides as well as c-series gangliosides, was disrupted.	Gangliosides	43-55	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	155-167
15847605-10	2005	NEU4 is possibly involved in regulation of apoptosis by modulation of ganglioside G(D3), which accumulates in mitochondria during apoptosis and is the best substrate for the sialidase.	Gangliosides	70-81	neuraminidase 4	Homo sapiens	0-4
15939439-5	2005	HG, TGF-beta1 (10 ng/ml) and d-threo-PDMP (20 microM) significantly stimulated the mesangial cell proliferation, whereas these increments were remarkable attenuated by exogenous ganglioside mixture (0.1-0.2 mg/ml) or GM3 (20-100 microM) in a dose-dependent manner.	Gangliosides	178-189	transforming growth factor, beta 1	Rattus norvegicus	4-13
15939439-8	2005	HG, TGF-beta1 and d-threo-PDMP induced a significant reduction of ganglioside expression with apparent changes in the composition of ganglioside GM3, and semi-quantitative analysis by HPTLC showed that ganglioside GM3 expression reduced to about 35-54% of control.	Gangliosides	66-77	transforming growth factor, beta 1	Rattus norvegicus	4-13
15939439-8	2005	HG, TGF-beta1 and d-threo-PDMP induced a significant reduction of ganglioside expression with apparent changes in the composition of ganglioside GM3, and semi-quantitative analysis by HPTLC showed that ganglioside GM3 expression reduced to about 35-54% of control.	Gangliosides	133-144	transforming growth factor, beta 1	Rattus norvegicus	4-13
15939439-8	2005	HG, TGF-beta1 and d-threo-PDMP induced a significant reduction of ganglioside expression with apparent changes in the composition of ganglioside GM3, and semi-quantitative analysis by HPTLC showed that ganglioside GM3 expression reduced to about 35-54% of control.	Gangliosides	133-144	transforming growth factor, beta 1	Rattus norvegicus	4-13
15939439-9	2005	These results provide a pathophysiological link between mesangial cell proliferation and ganglioside GM3 expression, indicating that exogenously added ganglioside GM3 inhibits the high-ambient glucose- and TGF-beta1-induced proliferation of cultured GMCs.	Gangliosides	89-100	transforming growth factor, beta 1	Rattus norvegicus	206-215
15953602-0	2005	Myelin-associated glycoprotein and complementary axonal ligands, gangliosides, mediate axon stability in the CNS and PNS: neuropathology and behavioral deficits in single- and double-null mice.	Gangliosides	65-77	myelin-associated glycoprotein	Mus musculus	0-30
15953602-4	2005	Mice lacking the ganglioside biosynthetic gene Galgt1 fail to express complex gangliosides, including GD1a and GT1b.	Gangliosides	17-28	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	47-53
15953602-4	2005	Mice lacking the ganglioside biosynthetic gene Galgt1 fail to express complex gangliosides, including GD1a and GT1b.	Gangliosides	78-90	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	47-53
15953602-12	2005	Similar neuropathological and behavioral deficits in Galgt1-, Mag-, and double-null mice support the hypothesis that MAG binding to gangliosides contributes to long-term axon-myelin stability.	Gangliosides	132-144	myelin-associated glycoprotein	Mus musculus	117-120
16192577-1	2005	PURPOSE: Bec2 is an anti-idiotypic antibody that mimics GD3, a ganglioside that is expressed on the surface of tumor cells and is of neuroectodermal origin.	Gangliosides	63-74	potassium voltage-gated channel subfamily H member 4	Homo sapiens	9-13
16192577-1	2005	PURPOSE: Bec2 is an anti-idiotypic antibody that mimics GD3, a ganglioside that is expressed on the surface of tumor cells and is of neuroectodermal origin.	Gangliosides	63-74	GRDX	Homo sapiens	56-59
15939439-3	2005	This study examined whether modulation of cellular ganglioside GM3 could regulate the high glucose- and transforming growth factor-beta1 (TGF-beta1)-induced proliferation of GMCs.	Gangliosides	51-62	transforming growth factor, beta 1	Rattus norvegicus	138-147
16116192-0	2005	Restoration by IL-15 of MHC class I antigen-processing machinery in human dendritic cells inhibited by tumor-derived gangliosides.	Gangliosides	117-129	interleukin 15	Homo sapiens	15-20
16116192-0	2005	Restoration by IL-15 of MHC class I antigen-processing machinery in human dendritic cells inhibited by tumor-derived gangliosides.	Gangliosides	117-129	MHC class I antigen	Homo sapiens	24-43
16116192-3	2005	In this article, we demonstrate that expression of several MHC class I APM components, including MB1 (beta5), LMP2, LMP7, LMP10, and ERp57, is significantly down-regulated in human DC generated in the presence of primary oral squamous cell carcinoma cell lines or coincubated with purified gangliosides.	Gangliosides	290-302	proteasome 20S subunit beta 5	Homo sapiens	97-100
16116192-5	2005	Furthermore, rIL-15 restored both tumor cell-induced and ganglioside-induced MHC class I APM component expression in DC, as well as their ability to present Ags to autologous Ag-specific T cells.	Gangliosides	57-68	interleukin 15	Rattus norvegicus	13-19
16116192-6	2005	These results demonstrate that IL-15 restores MHC class I APM component expression in DC down-regulated by tumor-derived gangliosides.	Gangliosides	121-133	interleukin 15	Homo sapiens	31-36
15896672-4	2005	In addition, incubation of calcitonin with cholesterol-rich and ganglioside-containing membranes resulted in significant changes in peptide structure yielding a peptide enriched in beta-sheet and amyloid content.	Gangliosides	64-75	calcitonin	Bos taurus	27-37
16040804-0	2005	Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
16040804-0	2005	Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.	Gangliosides	0-11	BCAR1 scaffold protein, Cas family member	Homo sapiens	58-65
16040804-0	2005	Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells.	Gangliosides	0-11	paxillin	Homo sapiens	70-78
15896672-5	2005	Because the cholesterol- and ganglioside-rich phospholipid systems enhanced the calcitonin beta-sheet and amyloid contents, and peptide amyloid content was associated with neurotoxicity, we then investigated whether depleting cellular cholesterol and gangliosides affected calcitonin neurotoxicity.	Gangliosides	29-40	calcitonin	Bos taurus	80-90
15896672-6	2005	We found that cholesterol and ganglioside removal significantly reduced the calcitonin-induced PC12 cell neurotoxicity.	Gangliosides	30-41	calcitonin-related polypeptide alpha	Rattus norvegicus	76-86
15980250-0	2005	Dietary ganglioside and long-chain polyunsaturated fatty acids increase ganglioside GD3 content and alter the phospholipid profile in neonatal rat retina.	Gangliosides	8-19	GRDX	Homo sapiens	84-87
15815977-2	2005	In this work we examine the binding and folding of the kinin peptide, bradykinin (BK), in the presence of the ganglioside monosialylated 1 (GM1) micelle.	Gangliosides	110-121	kininogen 1	Homo sapiens	70-80
15815977-2	2005	In this work we examine the binding and folding of the kinin peptide, bradykinin (BK), in the presence of the ganglioside monosialylated 1 (GM1) micelle.	Gangliosides	110-121	kininogen 1	Homo sapiens	82-84
15967512-0	2005	Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire.	Gangliosides	91-102	immunoglobulin heavy variable 4-38-2-like	Homo sapiens	24-54
16092056-10	2005	Thus, PMS and CS, but not LMS or intralysosomal sialidase, may play important roles in ethanol-modulated desialylation of gangliosides and consequent liver injury and behavioral alterations.	Gangliosides	122-134	neuraminidase 2	Rattus norvegicus	14-16
15923193-8	2005	Three basic residue-rich regions in the N-terminal targeting region have similarity to the MARCKS proteins and were found to control AKAP12 localization to ganglioside-rich regions at the cell periphery.	Gangliosides	156-167	A-kinase anchoring protein 12	Homo sapiens	133-139
15922866-1	2005	Low (< or = 35%) or absent expression of the complex "b" pathway gangliosides GD1b, GT1b and GQ1b (CbG) correlates with an aggressive biological phenotype in human neuroblastoma tumors.	Gangliosides	68-80	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	102-105
15980250-0	2005	Dietary ganglioside and long-chain polyunsaturated fatty acids increase ganglioside GD3 content and alter the phospholipid profile in neonatal rat retina.	Gangliosides	72-83	GRDX	Homo sapiens	84-87
15980250-1	2005	PURPOSE: During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina.	Gangliosides	39-50	GRDX	Homo sapiens	108-111
15980250-1	2005	PURPOSE: During early development, the ganglioside composition of the retina changes significantly, in that GD3 becomes the primary ganglioside in the mammalian retina.	Gangliosides	132-143	GRDX	Homo sapiens	108-111
15980250-12	2005	CONCLUSIONS: Animals fed dietary ganglioside increased in total retinal ganglioside and GD3 content during retinal development, with a concomitant alteration of phospholipid metabolism.	Gangliosides	33-44	GRDX	Homo sapiens	88-91
15929062-9	2005	In addition, HPTLC analysis in this system showed the expression of 9-O-acetyl GD3, a ganglioside that has been associated with neuronal migration.	Gangliosides	86-97	GRDX	Homo sapiens	79-82
15883181-3	2005	Of particular relevance to the amyloidoses, incubation of calcitonin with cholesterol-rich and ganglioside-containing membranes resulted in significant enrichment in the beta-sheet and amyloid content of the peptide.	Gangliosides	95-106	calcitonin	Bos taurus	58-68
15953345-0	2005	Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction.	Gangliosides	62-74	myelin-associated glycoprotein	Mus musculus	19-49
15953345-0	2005	Binding of soluble myelin-associated glycoprotein to specific gangliosides induces the association of p75NTR to lipid rafts and signal transduction.	Gangliosides	62-74	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	102-108
15953345-2	2005	Here we show that gangliosides, GT1b and GD1a, as well as the Nogo receptor, are functional binding partners for soluble MAG-Fc.	Gangliosides	18-30	myelin-associated glycoprotein	Mus musculus	121-124
15953345-7	2005	These findings establish gangliosides as functional binding partners for soluble MAG.	Gangliosides	25-37	myelin-associated glycoprotein	Mus musculus	81-84
15953345-8	2005	Gangliosides may play a role in translocation of p75(NTR.)	Gangliosides	0-12	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	49-52
15958592-8	2005	Gangliosides were found to participate in the induction of T-cell apoptosis, because the glucosylceramide synthase inhibitor (PPPP) significantly reduced the abilities of all four apoptogenic lines to kill the lymphocytes.	Gangliosides	0-12	UDP-glucose ceramide glucosyltransferase	Homo sapiens	89-114
16081368-0	2005	The ganglioside GD3 as the Greek goddess Hecate: several faces turned towards as many directions.	Gangliosides	4-15	GRDX	Homo sapiens	16-19
15936020-2	2005	The MDR1 overexpressing cells display a approximately 3-fold increased level of lactosylceramide and an increased ganglioside mass.	Gangliosides	114-125	ATP binding cassette subfamily B member 1	Homo sapiens	4-8
15960850-8	2005	In order to demonstrate the utility of our fluid membrane array technology to ligand/receptor studies, we investigated the multivalent binding of the cholera toxin B-subunit (CTB) to the membrane ganglioside GM1.	Gangliosides	196-207	phosphate cytidylyltransferase 1B, choline	Homo sapiens	150-173
15960850-8	2005	In order to demonstrate the utility of our fluid membrane array technology to ligand/receptor studies, we investigated the multivalent binding of the cholera toxin B-subunit (CTB) to the membrane ganglioside GM1.	Gangliosides	196-207	phosphate cytidylyltransferase 1B, choline	Homo sapiens	175-178
15865936-3	2005	This ganglioside triggers the activation of 12-Lox (12-lipoxygenase) leading to oxidative stress and apoptosis via the induction of the transcription factor Gadd153 and the Bcl-2-family member protein Bak.	Gangliosides	5-16	arachidonate 15-lipoxygenase	Homo sapiens	44-50
15865936-3	2005	This ganglioside triggers the activation of 12-Lox (12-lipoxygenase) leading to oxidative stress and apoptosis via the induction of the transcription factor Gadd153 and the Bcl-2-family member protein Bak.	Gangliosides	5-16	arachidonate 15-lipoxygenase	Homo sapiens	52-67
15865936-3	2005	This ganglioside triggers the activation of 12-Lox (12-lipoxygenase) leading to oxidative stress and apoptosis via the induction of the transcription factor Gadd153 and the Bcl-2-family member protein Bak.	Gangliosides	5-16	DNA damage inducible transcript 3	Homo sapiens	157-164
15865936-3	2005	This ganglioside triggers the activation of 12-Lox (12-lipoxygenase) leading to oxidative stress and apoptosis via the induction of the transcription factor Gadd153 and the Bcl-2-family member protein Bak.	Gangliosides	5-16	BCL2 apoptosis regulator	Homo sapiens	173-178
15865936-3	2005	This ganglioside triggers the activation of 12-Lox (12-lipoxygenase) leading to oxidative stress and apoptosis via the induction of the transcription factor Gadd153 and the Bcl-2-family member protein Bak.	Gangliosides	5-16	BCL2 antagonist/killer 1	Homo sapiens	201-204
15718418-4	2005	In vitro, in the presence of interleukin-3 (IL-3) and stem cell factor (SCF) these cells differentiate only into a granulated mast cell that now expresses CD13, c-kit, mast cell-specific gangliosides, FcepsilonRI, and binds immunoglobulin E (IgE).	Gangliosides	187-199	kit ligand	Mus musculus	72-75
15625180-9	2005	Furthermore, when ganglioside biosynthesis was blocked using PPMP, a glucosylceramide synthase inhibitor, the effects of glucosamine on pericyte proliferation were partially reversed.	Gangliosides	18-29	UDP-glucose ceramide glucosyltransferase	Homo sapiens	69-94
15958123-6	2005	This has been achieved through use of glycosyltransferase and complement regulator knock-out mice, both for cloning anti-ganglioside antibodies and inducing disease.	Gangliosides	121-132	protein O-linked mannose beta 1,4-N-acetylglucosaminyltransferase 2	Mus musculus	38-57
15963050-7	2005	However, both gangliosides suppressed expression of CD40, CD80, CD86 and major histocompatibility complex class II on DCs.	Gangliosides	14-26	CD40 molecule	Homo sapiens	52-56
15963050-7	2005	However, both gangliosides suppressed expression of CD40, CD80, CD86 and major histocompatibility complex class II on DCs.	Gangliosides	14-26	CD80 molecule	Homo sapiens	58-62
15963050-7	2005	However, both gangliosides suppressed expression of CD40, CD80, CD86 and major histocompatibility complex class II on DCs.	Gangliosides	14-26	CD86 molecule	Homo sapiens	64-68
15890474-1	2005	Promoters of the glycosyltransferase genes for ganglioside synthesis are TATA-less and often have multiple binding sites for transcription factors Sp1 and AP2 in their proximal regions.	Gangliosides	47-58	transcription factor AP-2, alpha	Mus musculus	155-158
15701648-3	2005	MAG, a member of the Siglec family of sialic acid-binding lectins, binds to sialoglycoconjugates on axons and particularly to gangliosides GD1a and GT1b, which may mediate some of the inhibitory effects of MAG.	Gangliosides	126-138	myelin-associated glycoprotein	Rattus norvegicus	0-3
15802303-5	2005	Specific glycan structures containing terminal GalNAc moieties, expressed by the human helminth parasite Schistosoma mansoni as well as tumor antigens and a subset of gangliosides, were identified as ligands for MGL.	Gangliosides	167-179	C-type lectin domain containing 10A	Homo sapiens	212-215
15802303-6	2005	Our results indicate an endogenous function for DC-expressed MGL in the clearance and tolerance to self-gangliosides, and in the pattern recognition of tumor antigens and foreign glycoproteins derived from helminth parasites.	Gangliosides	104-116	C-type lectin domain containing 10A	Homo sapiens	61-64
15716350-7	2005	Clustering G(M1) gangliosides enhanced clathrin-independent BCR internalization, and this required actin.	Gangliosides	17-29	BCR activator of RhoGEF and GTPase	Homo sapiens	60-63
15710618-3	2005	Growth of human embryonal WI38 fibroblasts is highly dependent on fibroblast growth factor (FGF) and its receptor (FGFR), stably associated with ganglioside GM3 and TSPs CD9 and CD81 in the ganglioside-enriched microdomain.	Gangliosides	190-201	CD81 molecule	Homo sapiens	178-182
15701648-8	2005	Prior studies indicated that blocking gangliosides reversed MAG inhibition.	Gangliosides	38-50	myelin-associated glycoprotein	Rattus norvegicus	60-63
15840168-4	2005	Using density gradient centrifugation and immunocytochemical analyses, we show that Env co-localizes with cholesterol, ganglioside GM1 and caveolin-1 in these specific regions of the plasma membrane.	Gangliosides	119-130	melanoma antigen	Mus musculus	84-87
15748213-0	2005	Fibronectin on activated T lymphocytes is bound to gangliosides and is present in detergent insoluble microdomains.	Gangliosides	51-63	fibronectin 1	Homo sapiens	0-11
15748213-4	2005	In the present study, we identified gangliosides within the T-cell membrane as specific binding sites for the N-terminal 30 kDa fragment of FN.	Gangliosides	36-48	fibronectin 1	Homo sapiens	140-142
15687347-1	2005	II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain.	Gangliosides	177-188	galactosidase, beta 1	Mus musculus	113-131
15792727-5	2005	Under well-defined conditions, an informative fragmentation pattern of the trisialylated ganglioside GT1 was obtained.	Gangliosides	89-100	beta-1,4-galactosyltransferase 1	Homo sapiens	101-104
15687347-1	2005	II3NeuAc-GgOse4Cer (GM1) gangliosidosis is an incurable lysosomal storage disease caused by a deficiency in acid beta-galactosidase (beta-gal), resulting in the accumulation of ganglioside GM1 and its asialo derivative GgOse4Cer (GA1) in the central nervous system, primarily in the brain.	Gangliosides	177-188	galactosidase, beta 1	Mus musculus	113-121
15632139-1	2005	Niemann-Pick type C (NPC) is an autosomal recessive lipid storage disorder characterized by lysosomal accumulation of cholesterol and gangliosides resulting from a defect in intracellular lipid trafficking.	Gangliosides	134-146	NPC intracellular cholesterol transporter 1	Homo sapiens	0-19
15748958-3	2005	We show that the A(-670)G SNP in the promoter region of Fas and high levels of sFas are associated with the presence of anti-ganglioside antibodies, suggesting that Fas-FasL interaction is involved in the production of cross-reactive antibodies in GBS.	Gangliosides	125-136	Fas ligand	Homo sapiens	169-173
15924714-12	2005	CONCLUSION: Compared with parental strain, galE mutant without ganglioside-like structure no longer could induce anti-GM1 antibodies, nor induce obvious immune damage of peripheral nerves in experimental guinea pigs.	Gangliosides	63-74	UDP-glucose 4-epimerase	Cavia porcellus	43-47
15816844-0	2005	Gangliosides inhibit urokinase-type plasminogen activator (uPA)-dependent squamous carcinoma cell migration by preventing uPA receptor/alphabeta integrin/epidermal growth factor receptor interactions.	Gangliosides	0-12	Epidermal growth factor receptor	Drosophila melanogaster	154-186
15816844-3	2005	Gangliosides are thought to regulate epithelial cell adhesion and migration by inhibiting alpha(5)beta(1) integrin and epidermal growth factor receptor (EGFR) signaling.	Gangliosides	0-12	Epidermal growth factor receptor	Drosophila melanogaster	119-151
15816844-3	2005	Gangliosides are thought to regulate epithelial cell adhesion and migration by inhibiting alpha(5)beta(1) integrin and epidermal growth factor receptor (EGFR) signaling.	Gangliosides	0-12	Epidermal growth factor receptor	Drosophila melanogaster	153-157
15632139-1	2005	Niemann-Pick type C (NPC) is an autosomal recessive lipid storage disorder characterized by lysosomal accumulation of cholesterol and gangliosides resulting from a defect in intracellular lipid trafficking.	Gangliosides	134-146	NPC intracellular cholesterol transporter 1	Homo sapiens	21-24
15306563-0	2005	TNFalpha-induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3.	Gangliosides	101-112	tumor necrosis factor	Homo sapiens	0-8
15632166-3	2005	279, 12213-12219) concluded that gangliosides serve as co-receptors for flagellin signaling via toll-like receptor 5 (TLR5).	Gangliosides	33-45	toll-like receptor 5	Mus musculus	96-116
15632166-3	2005	279, 12213-12219) concluded that gangliosides serve as co-receptors for flagellin signaling via toll-like receptor 5 (TLR5).	Gangliosides	33-45	toll-like receptor 5	Mus musculus	118-122
15632166-8	2005	Exogenous addition of mixed gangliosides (GM1, GD1a, and GT1b) as well as GD1a itself inhibited flagellin-induced interleukin-1 receptor-associated kinase activation as well as tumor necrosis factor alpha production in HeNC2, THP-1, and RAW 264.7 cells.	Gangliosides	28-40	coenzyme Q10A	Mus musculus	42-45
15632166-8	2005	Exogenous addition of mixed gangliosides (GM1, GD1a, and GT1b) as well as GD1a itself inhibited flagellin-induced interleukin-1 receptor-associated kinase activation as well as tumor necrosis factor alpha production in HeNC2, THP-1, and RAW 264.7 cells.	Gangliosides	28-40	GLI family zinc finger 2	Homo sapiens	226-231
15731030-0	2005	Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities.	Gangliosides	90-101	ATPase, class II, type 9A	Mus musculus	41-44
15731030-0	2005	Mucosal adjuvant properties of mutant LT-IIa and LT-IIb enterotoxins that exhibit altered ganglioside-binding activities.	Gangliosides	90-101	ATPase, class II, type 9B	Mus musculus	52-55
15656989-0	2005	Expression of the mouse WNK1 gene in correlation with ganglioside GD3 and functional analysis of the mouse WNK1 promoter.	Gangliosides	54-65	WNK lysine deficient protein kinase 1	Mus musculus	24-28
15385432-5	2005	In PMA-stimulated HL-60 cells, the PKC/ERKs-dependent CREB activation regulated expression of GM3 synthase, inducing a synthesis of ganglioside GM3 product.	Gangliosides	132-143	cAMP responsive element binding protein 1	Homo sapiens	54-58
15385432-5	2005	In PMA-stimulated HL-60 cells, the PKC/ERKs-dependent CREB activation regulated expression of GM3 synthase, inducing a synthesis of ganglioside GM3 product.	Gangliosides	132-143	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	94-106
15385432-7	2005	Interestingly, the increased ganglioside GM3 through PKC/ERKs/CREB-dependent pathway by PMA resulted in an increase of CD11b surface antigen expression and induction of HL-60 cells adherence.	Gangliosides	29-40	cAMP responsive element binding protein 1	Homo sapiens	62-66
15385432-7	2005	Interestingly, the increased ganglioside GM3 through PKC/ERKs/CREB-dependent pathway by PMA resulted in an increase of CD11b surface antigen expression and induction of HL-60 cells adherence.	Gangliosides	29-40	integrin subunit alpha M	Homo sapiens	119-124
15385432-9	2005	Furthermore, treatment of HL-60 cells with exogenous ganglioside GM3 induced CD11b expression.	Gangliosides	53-64	integrin subunit alpha M	Homo sapiens	77-82
15483268-3	2005	Both isoforms can remove nonreducing beta-N-acetyl-D-glucosamine residues, whereas HexA hydrolyzes charged substrates as G(M2) gangliosides as well.	Gangliosides	127-139	hexosaminidase subunit alpha	Homo sapiens	83-87
15642902-8	2005	There was a tendency toward an association between certain HLA alleles and several anti-ganglioside antibodies.	Gangliosides	88-99	major histocompatibility complex, class II, DR beta 1	Homo sapiens	59-62
15306563-4	2005	In other studies we have found a selective increase in the acidic glycosphingolipid ganglioside GM3 in 3T3-L1 adipocytes treated with TNFalpha, suggesting a specific function for GM3.	Gangliosides	84-95	tumor necrosis factor	Homo sapiens	134-142
15781998-0	2005	Changes in ganglioside content affect the binding of Clostridium perfringens epsilon-toxin to detergent-resistant membranes of Madin-Darby canine kidney cells.	Gangliosides	11-22	pCP8533etx_p28	Clostridium perfringens	77-90
15868592-3	2005	Recent studies suggest that neuroblastoma (NB)-derived gangliosides impair DC maturation, IL-12 secretion, and NK/T-cell activity.	Gangliosides	55-67	Rho guanine nucleotide exchange factor (GEF) 16	Mus musculus	28-41
15868592-4	2005	Neuroblastoma ganglioside-mediated abrogation of CD40 expression by DC and tumor-induced tolerance has not been studied.	Gangliosides	14-25	Rho guanine nucleotide exchange factor (GEF) 16	Mus musculus	0-13
15868592-4	2005	Neuroblastoma ganglioside-mediated abrogation of CD40 expression by DC and tumor-induced tolerance has not been studied.	Gangliosides	14-25	CD40 antigen	Mus musculus	49-53
15868592-16	2005	CONCLUSIONS: Neuroblastoma-induced inhibition of DC function may result from ganglioside-mediated CD40 signaling deficiency.	Gangliosides	77-88	Rho guanine nucleotide exchange factor (GEF) 16	Mus musculus	13-26
15868592-16	2005	CONCLUSIONS: Neuroblastoma-induced inhibition of DC function may result from ganglioside-mediated CD40 signaling deficiency.	Gangliosides	77-88	CD40 antigen	Mus musculus	98-102
15507708-5	2005	In addition, VLPs bind to glycolipids, such as lactosylceramide and gangliosides including GM3, GD2, GD3, GD1b, GT1b, and GQ1b, and VLP weakly bind to GD1a.	Gangliosides	68-80	VHL like	Homo sapiens	13-16
15534203-1	2004	In the mouse fibroblast cell line C3H 10T1/2 and the chicken fibroblast cell line DF1, the ganglioside GM3 is the major glycosphingolipid component of the plasma membrane.	Gangliosides	91-102	granulocyte macrophage antigen 3	Mus musculus	103-106
15709486-2	2005	Using model membrane/liposome systems the interaction of Abeta with specific lipids (e.g. phospholipids, gangliosides, cholesterol) has been defined.	Gangliosides	105-117	amyloid beta precursor protein	Homo sapiens	57-62
15650234-4	2004	Upstream events of fenretinide-induced signaling involve increased levels of ceramide as a result of increased sphingomyelinase activity, and the subsequent metabolism of ceramide to gangliosides via glucosylceramide synthase and GD3 synthase.	Gangliosides	183-195	UDP-glucose ceramide glucosyltransferase	Homo sapiens	200-225
15650234-5	2004	These gangliosides may be involved in the regulation of 12-LOX leading to oxidative stress and apoptosis via the induction of GADD153 and BAK.	Gangliosides	6-18	arachidonate 15-lipoxygenase	Homo sapiens	56-62
15650234-5	2004	These gangliosides may be involved in the regulation of 12-LOX leading to oxidative stress and apoptosis via the induction of GADD153 and BAK.	Gangliosides	6-18	DNA damage inducible transcript 3	Homo sapiens	126-133
15498585-1	2004	UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase (Gal-T2) transfers galactose to the terminal N-acetylgalactosamine of either the neutral glycolipid GA2 or of the gangliosides GM2, GD2 and GT2.	Gangliosides	160-172	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	Mus musculus	0-45
15390122-4	2004	Our results show that gangliosides induce the expression of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase.	Gangliosides	22-34	interleukin 1 beta	Rattus norvegicus	60-82
15390122-4	2004	Our results show that gangliosides induce the expression of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase.	Gangliosides	22-34	tumor necrosis factor	Rattus norvegicus	84-111
15390122-4	2004	Our results show that gangliosides induce the expression of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase.	Gangliosides	22-34	tumor necrosis factor	Rattus norvegicus	113-122
15390122-4	2004	Our results show that gangliosides induce the expression of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase.	Gangliosides	22-34	nitric oxide synthase 2	Rattus norvegicus	129-160
15390122-4	2004	Our results show that gangliosides induce the expression of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase.	Gangliosides	22-34	nitric oxide synthase 2	Rattus norvegicus	162-166
15390122-4	2004	Our results show that gangliosides induce the expression of interleukin (IL)-1beta, tumor necrosis factor-alpha (TNF-alpha), and inducible nitric oxide synthase (iNOS) in rat brain microglia and BV2 murine microglia via protein kinase C (PKC) and NADPH oxidase.	Gangliosides	22-34	protein kinase C, alpha	Rattus norvegicus	238-241
15390122-5	2004	Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]).	Gangliosides	47-58	interleukin 1 beta	Rattus norvegicus	14-22
15390122-5	2004	Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]).	Gangliosides	47-58	tumor necrosis factor	Rattus norvegicus	24-33
15390122-5	2004	Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]).	Gangliosides	47-58	nitric oxide synthase 2	Rattus norvegicus	39-43
15390122-5	2004	Expression of IL-1beta, TNF-alpha, and iNOS in ganglioside-treated cells was significantly reduced in the presence of inhibitors of PKC (GF109203X, Go6976, Ro31-8220, and rottlerin) and NADPH oxidase (diphenyleneiodonium chloride [DPI]).	Gangliosides	47-58	protein kinase C, alpha	Rattus norvegicus	132-135
15464996-0	2004	Gangliosides of organ-confined versus metastatic androgen-receptor-negative prostate cancer.	Gangliosides	0-12	androgen receptor	Homo sapiens	49-66
15525334-4	2004	To elucidate the biological functions of gangliosides in neural progenitor cells, we transfected an immortalized neural progenitor cell line, C17.2, which does not express GD3 ganglioside, with a fusion protein of GD3-synthase (ST-II) and enhanced green fluorescent protein (ST-II-EGFP).	Gangliosides	41-53	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	214-226
15525334-4	2004	To elucidate the biological functions of gangliosides in neural progenitor cells, we transfected an immortalized neural progenitor cell line, C17.2, which does not express GD3 ganglioside, with a fusion protein of GD3-synthase (ST-II) and enhanced green fluorescent protein (ST-II-EGFP).	Gangliosides	41-52	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	214-226
15662848-7	2004	Some alternatively spliced isoforms of NCX1 in the nuclear envelope of both cell types were tightly associated with ganglioside GM1.	Gangliosides	116-127	solute carrier family 8 member A1	Homo sapiens	39-43
15390122-6	2004	In response to gangliosides, PKC-alpha, betaII, and delta and NADPH oxidase p67(phox) translocated from the cytosol to the membrane.	Gangliosides	15-27	protein kinase C, alpha	Rattus norvegicus	29-38
15390122-6	2004	In response to gangliosides, PKC-alpha, betaII, and delta and NADPH oxidase p67(phox) translocated from the cytosol to the membrane.	Gangliosides	15-27	methionyl aminopeptidase 2	Rattus norvegicus	76-79
15390122-8	2004	Ganglioside-induced ROS generation was blocked by PKC inhibitors.	Gangliosides	0-11	protein kinase C, alpha	Rattus norvegicus	50-53
15390122-9	2004	Furthermore, ganglioside-induced activation of NF-kappaB, an essential transcription factor that mediates the expression of IL-1beta, TNF-alpha, and iNOS, was reduced in the presence of GF109203X and DPI.	Gangliosides	13-24	interleukin 1 beta	Rattus norvegicus	124-132
15390122-9	2004	Furthermore, ganglioside-induced activation of NF-kappaB, an essential transcription factor that mediates the expression of IL-1beta, TNF-alpha, and iNOS, was reduced in the presence of GF109203X and DPI.	Gangliosides	13-24	tumor necrosis factor	Rattus norvegicus	134-143
15390122-9	2004	Furthermore, ganglioside-induced activation of NF-kappaB, an essential transcription factor that mediates the expression of IL-1beta, TNF-alpha, and iNOS, was reduced in the presence of GF109203X and DPI.	Gangliosides	13-24	nitric oxide synthase 2	Rattus norvegicus	149-153
15390122-10	2004	Our results collectively suggest that gangliosides activate microglia via PKC and NADPH oxidase, which regulate activation of NF-kappaB.	Gangliosides	38-50	protein kinase C, alpha	Rattus norvegicus	74-77
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Gangliosides	206-218	glycolipid transfer protein	Homo sapiens	0-27
15504043-1	2004	Glycolipid transfer protein (GLTP) catalyzes the intermembrane transfer of lipids that have sugars beta-linked to either diacylglycerol or ceramide backbones, including simple glycosphingolipids (GSLs) and gangliosides.	Gangliosides	206-218	glycolipid transfer protein	Homo sapiens	29-33
15666818-8	2004	Mutations in the npc1 gene results in lysosomal accumulation of cholesterol and gangliosides in humans and in the mouse, which also recapitulates the onset of neurological deficits, neuronal loss and death typical of the most severe form of the human disease.	Gangliosides	80-92	NPC intracellular cholesterol transporter 1	Homo sapiens	17-21
15666818-10	2004	ALLO treatment was highly effective; ALLO-treated NP-C mice had substantially increased survival and delays in neurologic impairments, coinciding with marked improvements in neuronal survival, and reduction of gangliosides.	Gangliosides	210-222	NPC intracellular cholesterol transporter 1	Homo sapiens	50-54
15502825-4	2004	GM3 synthase is a member of the sialyltransferase family and catalyzes the initial step in the biosynthesis of most complex gangliosides from lactosylceramide.	Gangliosides	124-136	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
15502825-5	2004	Biochemical analysis of plasma glycosphingolipids confirmed that affected individuals lack GM3 synthase activity, as marked by a complete lack of GM3 ganglioside and its biosynthetic derivatives and an increase in lactosylceramide and its alternative derivatives.	Gangliosides	150-161	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	91-103
15557818-0	2004	Protein kinase A mediates microglial activation induced by plasminogen and gangliosides.	Gangliosides	75-87	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	0-16
15557818-3	2004	Both plasminogen and gangliosides induced IL-1beta, TNF-alpha and iNOS mRNA expression, and that this expression was inhibited by the addition of the PKA inhibitors, KT5720 and H89.	Gangliosides	21-33	interleukin 1 beta	Mus musculus	42-50
15557818-3	2004	Both plasminogen and gangliosides induced IL-1beta, TNF-alpha and iNOS mRNA expression, and that this expression was inhibited by the addition of the PKA inhibitors, KT5720 and H89.	Gangliosides	21-33	tumor necrosis factor	Mus musculus	52-61
15557818-3	2004	Both plasminogen and gangliosides induced IL-1beta, TNF-alpha and iNOS mRNA expression, and that this expression was inhibited by the addition of the PKA inhibitors, KT5720 and H89.	Gangliosides	21-33	nitric oxide synthase 2, inducible	Mus musculus	66-70
15557818-3	2004	Both plasminogen and gangliosides induced IL-1beta, TNF-alpha and iNOS mRNA expression, and that this expression was inhibited by the addition of the PKA inhibitors, KT5720 and H89.	Gangliosides	21-33	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	150-153
15557818-4	2004	Both plasminogen and gangliosides activated PKA and increased the DNA binding activity of the cAMP response element- binding protein (CREB).	Gangliosides	21-33	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	44-47
15557818-4	2004	Both plasminogen and gangliosides activated PKA and increased the DNA binding activity of the cAMP response element- binding protein (CREB).	Gangliosides	21-33	cAMP responsive element binding protein 1	Mus musculus	94-132
15557818-4	2004	Both plasminogen and gangliosides activated PKA and increased the DNA binding activity of the cAMP response element- binding protein (CREB).	Gangliosides	21-33	cAMP responsive element binding protein 1	Mus musculus	134-138
15557818-6	2004	These results suggest that PKA plays an important role in plasminogen and gangliosides- induced microglial activation.	Gangliosides	74-86	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	27-30
15498585-1	2004	UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase (Gal-T2) transfers galactose to the terminal N-acetylgalactosamine of either the neutral glycolipid GA2 or of the gangliosides GM2, GD2 and GT2.	Gangliosides	160-172	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	Mus musculus	47-53
15498585-1	2004	UDP-Gal:GA2/GM2/GD2/GT2 galactosyltransferase (Gal-T2) transfers galactose to the terminal N-acetylgalactosamine of either the neutral glycolipid GA2 or of the gangliosides GM2, GD2 and GT2.	Gangliosides	160-172	guanine nucleotide binding protein, alpha transducing 2	Mus musculus	20-23
15203115-7	2004	The results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane, and get internalized together after ganglioside cross-linking by cholera toxin or addition of an antibody against only one of the proteins.	Gangliosides	126-137	prion like protein doppel	Homo sapiens	29-35
15203115-7	2004	The results demonstrate that Doppel and PrPc co-patch extensively at the plasma membrane, and get internalized together after ganglioside cross-linking by cholera toxin or addition of an antibody against only one of the proteins.	Gangliosides	126-137	prion protein	Homo sapiens	40-44
15388255-1	2004	CD99 is a 32kDa surface glycoprotein, which is involved in the migration of leukocytes and the transport of ganglioside GM1 and transmembrane proteins.	Gangliosides	108-119	CD99 molecule (Xg blood group)	Homo sapiens	0-4
15492717-2	2004	Antibodies can react with glycoproteins such as myelin associated glycoprotein (MAG), or gangliosides containing one sialosyl epitope such as GM1 or several sialosyl epitopes (polysialyted gangliosides) including GD2, GD3, GT1b, GT1a, GQ1b.	Gangliosides	89-101	GRDX	Homo sapiens	218-221
15357583-0	2004	Interhalogens (ICl/IBr) and AgOTf in thioglycoside activation; synthesis of bislactam analogues of ganglioside GD3.	Gangliosides	99-110	GRDX	Homo sapiens	111-114
15448031-7	2004	Likewise, IFN-gamma mRNA and protein production were inhibited when T cells were cocultured with either renal cell carcinoma supernatant-derived gangliosides or a commercial source of purified GD1a.	Gangliosides	145-157	interferon gamma	Homo sapiens	10-19
15448031-9	2004	CONCLUSIONS: We propose that renal cell carcinoma-derived tumor products such as gangliosides can induce a type 2 bias in antitumor immunity by initiating apoptosis in the IFN-gamma-producing type 1 effector cells.	Gangliosides	81-93	interferon gamma	Homo sapiens	172-181
15327957-1	2004	GM2-activator protein (GM2-AP) is a lipid transfer protein that has the ability to stimulate the enzymatic processing of gangliosides as well as T-cell activation through lipid presentation.	Gangliosides	121-133	ganglioside GM2 activator	Homo sapiens	0-21
15327957-1	2004	GM2-activator protein (GM2-AP) is a lipid transfer protein that has the ability to stimulate the enzymatic processing of gangliosides as well as T-cell activation through lipid presentation.	Gangliosides	121-133	ganglioside GM2 activator	Homo sapiens	23-29
15289269-1	2004	Anti-disialoside antibodies (Abs) that bind NeuAc(alpha2-8) NeuAc epitopes on GQ1b and related gangliosides are found in human autoimmune neuropathy sera and are considered to be pathogenic.	Gangliosides	95-107	immunoglobulin binding protein 1	Homo sapiens	50-58
15175257-0	2004	Myelin-associated glycoprotein (Siglec-4) expression is progressively and selectively decreased in the brains of mice lacking complex gangliosides.	Gangliosides	134-146	myelin-associated glycoprotein	Mus musculus	0-30
15175257-3	2004	MAG, a member of the Siglec family of sialic acid-binding lectins, binds specifically to gangliosides GD1a and GT1b, which are the major sialoglycoconjugates on mammalian axons.	Gangliosides	89-101	myelin associated glycoprotein	Homo sapiens	0-3
15175257-11	2004	We conclude that the maintenance of MAG protein levels depends on the presence of complex gangliosides, perhaps due to enhanced stability when MAG on myelin binds to its complementary ligands, GD1a and GT1b, on the apposing axon surface.	Gangliosides	90-102	myelin-associated glycoprotein	Mus musculus	36-39
15213228-5	2004	We demonstrate that Neu4 is ubiquitously expressed in human tissues and has broad substrate specificity by being active against sialylated oligosaccharides, glycoproteins, and gangliosides.	Gangliosides	176-188	neuraminidase 4	Homo sapiens	20-24
15322154-5	2004	Binding of LFA-1 on CTL to targets initiates the formation of the immunological synapse, which is formed by LFA-1, CD3, and ganglioside GM1 distributed in the periphery of the cell contact site and cholesterol is more widely distributed.	Gangliosides	124-135	integrin subunit alpha L	Homo sapiens	11-16
15339967-2	2004	Metabolism of ceramide involves several enzymes, including glucosylceramide synthase and GD3 synthase, and results in the formation of gangliosides (GM3, GD3, and GT3), which in turn promote the generation of reactive oxygen species (ROS) and apoptosis.	Gangliosides	135-147	UDP-glucose ceramide glucosyltransferase	Homo sapiens	59-84
15339967-2	2004	Metabolism of ceramide involves several enzymes, including glucosylceramide synthase and GD3 synthase, and results in the formation of gangliosides (GM3, GD3, and GT3), which in turn promote the generation of reactive oxygen species (ROS) and apoptosis.	Gangliosides	135-147	GRDX	Homo sapiens	89-92
15339967-2	2004	Metabolism of ceramide involves several enzymes, including glucosylceramide synthase and GD3 synthase, and results in the formation of gangliosides (GM3, GD3, and GT3), which in turn promote the generation of reactive oxygen species (ROS) and apoptosis.	Gangliosides	135-147	GRDX	Homo sapiens	154-157
15339967-8	2004	Fenretinide also induced increased levels of GD2, a ganglioside derived from GD3.	Gangliosides	52-63	GRDX	Homo sapiens	77-80
15381831-5	2004	Among the gangliosides, O-Ac-GD3, GT(1b), GD(1a), GD(1b), GT(1a), and GD3 had potent dose dependent inhibitory effects on adhesion of H. pylori to MKN-45 cells, interleukin-8 production, and vacuole formation induced by H. pylori toxin binding to Vero cells.	Gangliosides	10-22	GRDX	Homo sapiens	29-32
15294298-4	2004	The binding of CTB-gp120 fusion protein pentamers to intestinal epithelial cell membrane glycolipid receptors was quantified by GM1-ganglioside enzyme-linked immunosorbent assay (GM1-ELISA).	Gangliosides	132-143	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	19-24
15215248-2	2004	Exposure of fibroblasts to exogenous gangliosides increases epidermal growth factor (EGF)-induced fibroblast proliferation and enhances EGF receptor (EGFR)-mediated activation of the mitogen-activated protein kinase signaling pathway (Li, R., Liu, Y., and Ladisch, S. (2001) J. Biol.	Gangliosides	37-49	epidermal growth factor receptor	Homo sapiens	136-148
15215248-2	2004	Exposure of fibroblasts to exogenous gangliosides increases epidermal growth factor (EGF)-induced fibroblast proliferation and enhances EGF receptor (EGFR)-mediated activation of the mitogen-activated protein kinase signaling pathway (Li, R., Liu, Y., and Ladisch, S. (2001) J. Biol.	Gangliosides	37-49	epidermal growth factor receptor	Homo sapiens	150-154
15215248-5	2004	Here we report that the EGFR itself is the target of this ganglioside effect: Preincubation of normal human dermal fibroblasts with G(D1a) ganglioside enhanced both EGF-induced EGFR autophosphorylation and receptor-tyrosine kinase activity.	Gangliosides	58-69	epidermal growth factor receptor	Homo sapiens	24-28
15215248-5	2004	Here we report that the EGFR itself is the target of this ganglioside effect: Preincubation of normal human dermal fibroblasts with G(D1a) ganglioside enhanced both EGF-induced EGFR autophosphorylation and receptor-tyrosine kinase activity.	Gangliosides	58-69	epidermal growth factor receptor	Homo sapiens	177-181
15215248-10	2004	We conclude that membrane ganglioside enrichment of normal fibroblasts (such as by tumor cell ganglioside shedding) facilitates receptor-receptor interactions (possibly by altering membrane topology), causing ligand-independent EGFR dimerization and, in turn, enhanced EGF signaling.	Gangliosides	26-37	epidermal growth factor receptor	Homo sapiens	228-232
15215248-10	2004	We conclude that membrane ganglioside enrichment of normal fibroblasts (such as by tumor cell ganglioside shedding) facilitates receptor-receptor interactions (possibly by altering membrane topology), causing ligand-independent EGFR dimerization and, in turn, enhanced EGF signaling.	Gangliosides	94-105	epidermal growth factor receptor	Homo sapiens	228-232
15277677-0	2004	Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome.	Gangliosides	35-46	coenzyme Q10A	Mus musculus	47-50
15487588-2	2004	Similar to the infantile/juvenile human disease forms, B6/129Sv beta-gal knockout (ko) mice express residual tissue beta-gal activity and significant elevations of brain GM1, GA1, and total gangliosides.	Gangliosides	190-202	galactosidase, beta 1	Mus musculus	64-72
15170821-10	2004	We conclude that sigma-1R cause the remodeling of lipid rafts, at least by increasing the level of lipid raft-associated cholesterol and by altering the levels of certain critical lipid raft-forming gangliosides.	Gangliosides	199-211	sigma non-opioid intracellular receptor 1	Rattus norvegicus	17-25
15207833-5	2004	Understanding the precise role of the endosomal-lysosomal system in the overall homeostatic control of GSL expression in neurons can be expected to provide key insight into both the function of gangliosides and the pathogenic mechanisms underlying lysosomal disease.	Gangliosides	194-206	cathepsin A	Homo sapiens	103-106
15196995-0	2004	Gangliosides modulate the activity of the plasma membrane Ca(2+)-ATPase from porcine brain synaptosomes.	Gangliosides	0-12	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	42-71
15170821-9	2004	Furthermore, while overexpression of sigma-1R increases the level of lipid raft-associated cholesterol, the overexpression alters the levels of gangliosides in lipid rafts: GM1 and GM2 are decreased, whereas GD1a is increased.	Gangliosides	144-156	sigma non-opioid intracellular receptor 1	Rattus norvegicus	37-45
15196995-1	2004	We systematically examined the effects of gangliosides on the plasma membrane Ca(2+)-ATPase (PMCA) from porcine brain synaptosomes.	Gangliosides	42-54	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	62-91
15196995-1	2004	We systematically examined the effects of gangliosides on the plasma membrane Ca(2+)-ATPase (PMCA) from porcine brain synaptosomes.	Gangliosides	42-54	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	93-97
15196995-9	2004	Moreover, the effects of gangliosides are additive to that of calmodulin, suggesting that the modulation of PMCA by gangliosides should be through a different mechanism.	Gangliosides	25-37	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	108-112
15196995-9	2004	Moreover, the effects of gangliosides are additive to that of calmodulin, suggesting that the modulation of PMCA by gangliosides should be through a different mechanism.	Gangliosides	116-128	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	108-112
15196995-11	2004	We found that fluorescent quenchers (I(-) and Cs(+)) with opposite charges had different accessibility to the IAEDANS binding to the PMCA in the presence of gangliosides.	Gangliosides	157-169	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	133-137
15225622-0	2004	Accelerated Abeta aggregation in the presence of GM1-ganglioside-accumulated synaptosomes of aged apoE4-knock-in mouse brain.	Gangliosides	53-64	coenzyme Q10A	Mus musculus	49-52
15196944-3	2004	However, the relationship between ganglioside GD3 and B-cell/CLL lymphoma 2 (Bcl-2) is not fully understood.	Gangliosides	34-45	GRDX	Homo sapiens	46-49
15213113-5	2004	We show that the receptor for Afa/Dr adhesins, glycosylphosphatidylinositol-anchored CD55; the raft marker, ganglioside GM1; and VIP21/caveolin are all recruited around adhering Dr-positive bacteria.	Gangliosides	108-119	AFA	Homo sapiens	30-33
15196944-3	2004	However, the relationship between ganglioside GD3 and B-cell/CLL lymphoma 2 (Bcl-2) is not fully understood.	Gangliosides	34-45	BCL2 apoptosis regulator	Homo sapiens	54-75
15196944-3	2004	However, the relationship between ganglioside GD3 and B-cell/CLL lymphoma 2 (Bcl-2) is not fully understood.	Gangliosides	34-45	BCL2 apoptosis regulator	Homo sapiens	77-82
14970224-3	2004	In addition, administration of the radiolabeled ganglioside GD1a to MmNEU3-transfected cells, under conditions that prevent lysosomal activity, led to its hydrolysis into ganglioside GM1, further indicating the plasma membrane topology of MmNEU3.	Gangliosides	48-59	coenzyme Q10A	Mus musculus	183-186
15182358-1	2004	Gangliosides have been found to reside in glycosphingolipid-enriched microdomains (GEM) of the plasma membrane and to be involved in the regulation of epidermal growth factor receptor (EGFr or ErbB1) activity.	Gangliosides	0-12	epidermal growth factor receptor	Cricetulus griseus	185-189
15182358-2	2004	To gain further insight into the mechanisms involved in EGFr modulation by gangliosides, we investigated the distribution of EGFr family members in the plasma membrane of CHO-K1 cells, which were genetically modified to express different ganglioside molecules or depleted of glycolipids.	Gangliosides	75-87	epidermal growth factor receptor	Cricetulus griseus	56-60
15182358-2	2004	To gain further insight into the mechanisms involved in EGFr modulation by gangliosides, we investigated the distribution of EGFr family members in the plasma membrane of CHO-K1 cells, which were genetically modified to express different ganglioside molecules or depleted of glycolipids.	Gangliosides	75-86	epidermal growth factor receptor	Cricetulus griseus	56-60
15149632-5	2004	Results demonstrate that the group treated with gangliosides displays mild disease, with low expression of IFN-gamma mRNA and high TGF-beta mRNA expression.	Gangliosides	48-60	interferon gamma	Rattus norvegicus	107-116
15149632-5	2004	Results demonstrate that the group treated with gangliosides displays mild disease, with low expression of IFN-gamma mRNA and high TGF-beta mRNA expression.	Gangliosides	48-60	transforming growth factor, beta 1	Rattus norvegicus	131-139
15179041-7	2004	We conclude that the sialidase activity of Neu3 is specific for gangliosides.	Gangliosides	64-76	neuraminidase 3	Homo sapiens	43-47
15152051-2	2004	We hypothesized previously that GM1 ganglioside-bound Abeta (GAbeta) is involved in the process.	Gangliosides	36-47	alpha glucosidase	Homo sapiens	61-67
14970224-6	2004	At the same time, a 35% increase in ganglioside GM1 content was observed.	Gangliosides	36-47	coenzyme Q10A	Mus musculus	48-51
15033442-4	2004	Uptake of the primer by B16 cells resulted in the sialylation of the terminal galactose residue to afford an oligosaccharide with the same glycan structure as ganglioside GM3.	Gangliosides	159-170	granulocyte macrophage antigen 3	Mus musculus	171-174
15064799-3	2004	Truncated gangliosides representive of GD3, GQ1b and GM2 epitopes have been synthesized as methyl glycosides and as a glycosides of an eleven carbon tether.	Gangliosides	10-22	GRDX	Homo sapiens	39-42
15080734-3	2004	The GSL species investigated were isomeric monosialogangliosides of the neolacto series from a ganglioside preparation of human granulocytes, the disialoganglioside GD3 from a human melanoma lipid extract, and ganglio series Gg3Cer of a neutral GSL preparation from murine lymphoreticular MDAY-D2 cells.	Gangliosides	52-63	cathepsin A	Homo sapiens	4-7
15099768-6	2004	rLTB from plant extracts of TMV-infected N. benthamiana leaves was purified to give 75 microg rLTB pentamers per gram fresh plant material and was capable of binding G(M)1 ganglioside.	Gangliosides	172-183	lymphotoxin beta	Rattus norvegicus	0-4
15051759-2	2004	Patches of cross-linked raft resident ganglioside GM1 colocalized with ULBP1, 2, 3, or MICA, but not CD45.	Gangliosides	38-49	UL16 binding protein 1	Homo sapiens	71-82
15051759-2	2004	Patches of cross-linked raft resident ganglioside GM1 colocalized with ULBP1, 2, 3, or MICA, but not CD45.	Gangliosides	38-49	MHC class I polypeptide-related sequence A	Homo sapiens	87-91
15085197-4	2004	Our results indicate that the expression of raft-associated ganglioside, GM1, is increased in T cells from SLE patients and LCK may be differentially regulated due to an alteration in the association of CD45 with lipid raft domains.	Gangliosides	60-71	protein tyrosine phosphatase receptor type C	Homo sapiens	203-207
14985092-1	2004	We report here the interaction of bradykinin with ganglioside GM1 by circular dichroism, steady-state fluorescence, and one-dimensional 1H NMR spectroscopy.	Gangliosides	50-61	kininogen 1	Homo sapiens	34-44
14707135-0	2004	Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells.	Gangliosides	0-12	defensin beta 4A	Homo sapiens	101-116
14707135-5	2004	In this study, we examined the role of ganglioside as co-receptors with Toll-like receptor 5 (TLR5) on FliC induction of hBD-2 expression in Caco-2 cells.	Gangliosides	39-50	defensin beta 4A	Homo sapiens	121-126
14707135-6	2004	Exogenous gangliosides suppressed FliC induction of hBD-2 promoter activity and binding of FliC to Caco-2 cells.	Gangliosides	10-22	defensin beta 4A	Homo sapiens	52-57
14707135-7	2004	Incorporation of exogenous ganglioside GD1a into Caco-2 cell membranes increased the effect of FliC on hBD-2 promoter activity.	Gangliosides	27-38	defensin beta 4A	Homo sapiens	103-108
14707135-11	2004	Exogenous gangliosides GD1a, GD1b, and GT1b each suppressed FliC induction of p38 and ERK1/2 phosphorylation.	Gangliosides	10-22	mitogen-activated protein kinase 1	Homo sapiens	78-81
14707135-11	2004	Exogenous gangliosides GD1a, GD1b, and GT1b each suppressed FliC induction of p38 and ERK1/2 phosphorylation.	Gangliosides	10-22	mitogen-activated protein kinase 3	Homo sapiens	86-92
14707135-13	2004	These results suggest that gangliosides act as co-receptors with TLR5 for FliC and promote hBD-2 expression via mitogen-activated protein kinase.	Gangliosides	27-39	toll like receptor 5	Homo sapiens	65-69
14707135-13	2004	These results suggest that gangliosides act as co-receptors with TLR5 for FliC and promote hBD-2 expression via mitogen-activated protein kinase.	Gangliosides	27-39	defensin beta 4A	Homo sapiens	91-96
14972652-1	2004	Tay-Sachs disease is an autosomal recessive neurodegenerative disease resulting from a block in the hydrolysis of GM2 ganglioside, an intermediate in ganglioside catabolism.	Gangliosides	118-129	cytochrome b5 domain containing 2	Mus musculus	114-117
15004148-0	2004	Degradation of NF-kappa B in T cells by gangliosides expressed on renal cell carcinomas.	Gangliosides	40-52	nuclear factor kappa B subunit 1	Homo sapiens	15-25
14987999-4	2004	Furthermore, hydrogen peroxide generated by the combination of ganglioside GD3 and mitochondrial GSH depletion elicited mitochondrial swelling and release of cytochrome c, Smac/Diablo and apoptosis-inducing factor in control mitochondria and CHM.	Gangliosides	63-74	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	172-176
15004148-7	2004	SK-RC-45 gangliosides appear to mediate this degradative pathway, as blocking ganglioside synthesis in SK-RC-45 cells with the glucosylceramide synthase inhibitor, PPPP, protected T cells from tumor cell-induced RelA degradation and apoptosis.	Gangliosides	9-20	UDP-glucose ceramide glucosyltransferase	Homo sapiens	127-152
15004148-7	2004	SK-RC-45 gangliosides appear to mediate this degradative pathway, as blocking ganglioside synthesis in SK-RC-45 cells with the glucosylceramide synthase inhibitor, PPPP, protected T cells from tumor cell-induced RelA degradation and apoptosis.	Gangliosides	9-20	RELA proto-oncogene, NF-kB subunit	Homo sapiens	212-216
15004148-8	2004	The ability of the Bcl-2 transgene to protect Jurkat cells from RelA degradation, caspase activation, and apoptosis implicates the mitochondria in these SK-RC-45 ganglioside-mediated effects.	Gangliosides	162-173	BCL2 apoptosis regulator	Homo sapiens	19-24
17147606-8	2004	The resulting chimera CTB-2L21 protein retained pentamerization and G(M1)-ganglioside binding characteristics of the native CTB and induced antibodies able to recognize VP2 protein from CPV.	Gangliosides	74-85	phosphate cytidylyltransferase 1B, choline	Homo sapiens	22-25
14662772-9	2004	Metabolic labeling in wild type and knock-out (MDR1a, 1b, MRP1) mouse fibroblasts showed the same loss of neutral glycosphingolipid (glucosyl ceramide, lactosyl ceramide) but not ganglioside (GM3) synthesis, confirming the proposed role for MDR1 translocase activity.	Gangliosides	179-190	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	47-52
14662772-9	2004	Metabolic labeling in wild type and knock-out (MDR1a, 1b, MRP1) mouse fibroblasts showed the same loss of neutral glycosphingolipid (glucosyl ceramide, lactosyl ceramide) but not ganglioside (GM3) synthesis, confirming the proposed role for MDR1 translocase activity.	Gangliosides	179-190	chemokine (C-C motif) ligand 6	Mus musculus	58-62
14662772-9	2004	Metabolic labeling in wild type and knock-out (MDR1a, 1b, MRP1) mouse fibroblasts showed the same loss of neutral glycosphingolipid (glucosyl ceramide, lactosyl ceramide) but not ganglioside (GM3) synthesis, confirming the proposed role for MDR1 translocase activity.	Gangliosides	179-190	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	47-51
14766296-8	2004	(His(6))-BoNT/B HC TBD retained binding to synaptotagmin II, the receptor of BoNT/B, which was confirmed by immunological dot blot assay, also to ganglioside, which was investigated using enzyme-linked immunosorbent assay.	Gangliosides	146-157	synaptotagmin 2	Homo sapiens	43-59
14987999-4	2004	Furthermore, hydrogen peroxide generated by the combination of ganglioside GD3 and mitochondrial GSH depletion elicited mitochondrial swelling and release of cytochrome c, Smac/Diablo and apoptosis-inducing factor in control mitochondria and CHM.	Gangliosides	63-74	diablo, IAP-binding mitochondrial protein	Rattus norvegicus	177-183
14728689-2	2004	The GM2-activator protein (GM2AP) is an essential cofactor for the degradation of ganglioside GM2 by lysosomal beta-hexosaminidase A.	Gangliosides	82-93	ganglioside GM2 activator	Homo sapiens	4-25
14728689-2	2004	The GM2-activator protein (GM2AP) is an essential cofactor for the degradation of ganglioside GM2 by lysosomal beta-hexosaminidase A.	Gangliosides	82-93	ganglioside GM2 activator	Homo sapiens	27-32
16998591-2	2004	This results from interactions between MAG and the Nogo receptor and gangliosides on the apposing axon, which generates intracellular inhibitory signals in the neuron.	Gangliosides	69-81	myelin associated glycoprotein	Homo sapiens	39-42
15002743-3	2004	Ganglioside GM1 binds tightly with Abeta and it is speculated that GM1 inhibits Abeta from undergoing alpha-helix to beta-sheet conformational changes.	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	35-40
15002743-3	2004	Ganglioside GM1 binds tightly with Abeta and it is speculated that GM1 inhibits Abeta from undergoing alpha-helix to beta-sheet conformational changes.	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	80-85
15002743-4	2004	Although the role of gangliosides in conformational changes of Abeta have been studied, the specific nature of these interactions have not been reported.	Gangliosides	21-33	amyloid beta precursor protein	Homo sapiens	63-68
15002743-5	2004	In the present report multidimensional NMR studies of ganglioside-Abeta interactions were conducted in sodium dodecyl sulphate (SDS) micelles, a membrane-mimicking environment.	Gangliosides	54-65	amyloid beta precursor protein	Homo sapiens	66-71
15038664-6	2004	For example, ceramide-induced apoptosis is associated with increased synthesis of a ganglioside, GD3.	Gangliosides	84-95	GRDX	Homo sapiens	97-100
14672816-2	2004	Neuraminidase (sialidase) increases levels of GM1, a monosialoganglioside, in these neurons by enzymatic removal of sialic acid from abundant polysialylated gangliosides.	Gangliosides	157-169	coenzyme Q10A	Mus musculus	46-49
14659673-3	2004	HPTLC immunostaining revealed that lymph nodes from TNFR1-/- mice had reduced expression of ganglioside GM1b and GalNAc-GM1b, neolacto-series gangliosides, as well as the globo- (Gb3, Gb4 and Gb5) and ganglio-series (Gg3 and Gg4) neutral GSLs.	Gangliosides	92-103	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	52-57
14659673-6	2004	This study provides in vivo evidence that TNF signalling via the TNFR1 is important for the activation of GM1b-type ganglioside biosynthetic pathway in CD8 T lymphocytes, suggesting its possible role in the effector T lymphocyte function.	Gangliosides	116-127	tumor necrosis factor	Mus musculus	42-45
14659673-6	2004	This study provides in vivo evidence that TNF signalling via the TNFR1 is important for the activation of GM1b-type ganglioside biosynthetic pathway in CD8 T lymphocytes, suggesting its possible role in the effector T lymphocyte function.	Gangliosides	116-127	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	65-70
15454696-3	2004	A recently characterized trafficking of ganglioside GD3 (GD3), a GSLs with two sialic-acid residues, to mitochondria has revealed a novel function of this lipid as a death effector.	Gangliosides	40-51	GRDX	Homo sapiens	52-55
15229395-3	2004	Noteworthy, the correct course of ganglioside/glycosphingolipid metabolism requires the presence of the vimentin intracellular filament net work, likely to assist intracellular transport of sphingoid molecules.	Gangliosides	34-45	vimentin	Homo sapiens	104-112
15454696-3	2004	A recently characterized trafficking of ganglioside GD3 (GD3), a GSLs with two sialic-acid residues, to mitochondria has revealed a novel function of this lipid as a death effector.	Gangliosides	40-51	GRDX	Homo sapiens	57-60
14512423-0	2003	Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	41-73
14722612-2	2004	Hexb(-/-) mice rapidly develop a progressive neurologic disease of ganglioside GM2 and GA2 storage.	Gangliosides	67-78	hexosaminidase B	Mus musculus	0-4
14674750-3	2003	Using the growth-regulatory interaction of the pentasaccharide of ganglioside GM(1) with homodimeric galectin-1 on neuroblastoma cell surfaces as a model, we present a suitable strategy for addressing this issue.	Gangliosides	66-77	galectin 1	Homo sapiens	101-111
14674750-11	2003	The finding that the ganglioside"s carbohydrate chain is subject to differential conformer selection at the sialylgalactose linkage by galectin-1 and GM(1)-binding cholera toxin (Phi and Psi values of -172 degrees and -26 degrees, respectively) is relevant for toxin-directed drug design.	Gangliosides	21-32	galectin 1	Homo sapiens	135-145
14512423-3	2003	Previous studies have shown that ligand-dependent EGFR activation is inhibited by GM3, the predominant ganglioside of epithelial cells, but the effect of GM3 on ligand-independent, integrin-EGFR cross-talk is unknown.	Gangliosides	103-114	epidermal growth factor receptor	Homo sapiens	50-54
14634121-3	2003	In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or IFN-gamma-stimulated induction of cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes.	Gangliosides	99-110	prostaglandin-endoperoxide synthase 2	Mus musculus	156-172
14634121-3	2003	In both rat primary microglia and murine BV2 microglial cells, curcumin effectively suppressed the ganglioside-, LPS-, or IFN-gamma-stimulated induction of cyclooxygenase-2 and inducible NO synthase, important enzymes that mediate inflammatory processes.	Gangliosides	99-110	nitric oxide synthase 2, inducible	Mus musculus	177-198
14634121-5	2003	Curcumin markedly inhibited the phosphorylation of STAT1 and 3 as well as JAK1 and 2 in microglia activated with gangliosides, LPS, or IFN-gamma.	Gangliosides	113-125	signal transducer and activator of transcription 1	Rattus norvegicus	51-62
14634121-5	2003	Curcumin markedly inhibited the phosphorylation of STAT1 and 3 as well as JAK1 and 2 in microglia activated with gangliosides, LPS, or IFN-gamma.	Gangliosides	113-125	Janus kinase 1	Rattus norvegicus	74-84
14667701-0	2003	Studies on the endogenous L-selectin ligands: systematic and highly efficient total synthetic routes to lactamized-sialyl 6-O-sulfo Lewis X and other novel gangliosides containing lactamized neuraminic acid.	Gangliosides	156-168	selectin L	Homo sapiens	26-36
14630342-1	2003	PC12 cells undergo neuritogenesis upon nerve growth factor (NGF) activation of the TrkA receptor, an effect mimicked by the ganglioside GM1 binding B-subunit of cholera toxin (CTB).	Gangliosides	124-135	neurotrophic receptor tyrosine kinase 1	Homo sapiens	83-87
14630342-1	2003	PC12 cells undergo neuritogenesis upon nerve growth factor (NGF) activation of the TrkA receptor, an effect mimicked by the ganglioside GM1 binding B-subunit of cholera toxin (CTB).	Gangliosides	124-135	phosphate cytidylyltransferase 1B, choline	Homo sapiens	176-179
12937083-1	2003	Miller Fisher syndrome-associated anti-GQ1b ganglioside antibodies produce an acute complement-dependent neuroexocytic effect at the mouse neuromuscular junction (NMJ) that closely resembles the effect of alpha-latrotoxin (LTx).	Gangliosides	44-55	lymphotoxin A	Mus musculus	205-221
14597183-1	2003	Lysosomal sialidase is required for the catabolism of sialoglycoconjugates such as gangliosides and deficiency in this enzyme results in the autosomal recessive disease sialidosis.	Gangliosides	83-95	neuraminidase 1	Mus musculus	0-19
14588011-3	2003	A clear-cut series of fragment ions for both types of isomeric gangliosides, carrying alpha2-3- and alpha2-6-linked neuraminic acid, respectively, was obtained by low-energy CID.	Gangliosides	63-75	immunoglobulin binding protein 1	Homo sapiens	100-108
14612523-5	2003	Higher CbG expression characterized nonprogressive versus progressive tumors (median 41% versus 18% of total gangliosides; P = 0.001) and completely accounted for the observed higher overall "b" pathway ganglioside expression (median 81% versus 68%; P = 0.003).	Gangliosides	109-121	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	7-10
12937083-1	2003	Miller Fisher syndrome-associated anti-GQ1b ganglioside antibodies produce an acute complement-dependent neuroexocytic effect at the mouse neuromuscular junction (NMJ) that closely resembles the effect of alpha-latrotoxin (LTx).	Gangliosides	44-55	lymphotoxin A	Mus musculus	223-226
14612523-5	2003	Higher CbG expression characterized nonprogressive versus progressive tumors (median 41% versus 18% of total gangliosides; P = 0.001) and completely accounted for the observed higher overall "b" pathway ganglioside expression (median 81% versus 68%; P = 0.003).	Gangliosides	109-120	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	7-10
14612523-8	2003	High CbG (> or =35% of total gangliosides) expression was strongly predictive of a favorable outcome in: (a) the entire study population (90% versus 60% EFS at 25 months; P = 0.001); and (b) among patients assigned a low-risk status by a either single genetic or biochemical tumor marker (MYCN, DNA, NSE, or ferritin), or by both unamplified MYCN and aneuploid DNA (22-28% difference in EFS at 25 months).	Gangliosides	32-44	glucosylceramidase beta 3 (gene/pseudogene)	Homo sapiens	5-8
13679866-3	2003	We show by solid-phase and cell assays that the sugar chain of this ganglioside is a ligand for galectin-7.	Gangliosides	68-79	galectin 7	Homo sapiens	96-106
14505645-0	2003	Novel sulfated gangliosides, high-affinity ligands for neural siglecs, inhibit NADase activity of leukocyte cell surface antigen CD38.	Gangliosides	15-27	CD38 molecule	Homo sapiens	129-133
14505645-2	2003	These sulfated gangliosides were potent inhibitors of NADase activity of leukocyte cell surface antigen CD38.	Gangliosides	15-27	CD38 molecule	Homo sapiens	104-108
15332492-4	2003	The six major gangliosides isolated from B16LuF10 cells corresponded with standard gangliosides GT1b, GD1b, GD1a, GM1, GM2 and GM3 respectively on TLC-analysis.	Gangliosides	14-26	coenzyme Q10A	Mus musculus	114-117
15332492-4	2003	The six major gangliosides isolated from B16LuF10 cells corresponded with standard gangliosides GT1b, GD1b, GD1a, GM1, GM2 and GM3 respectively on TLC-analysis.	Gangliosides	14-26	cytochrome b5 domain containing 2	Mus musculus	119-122
15332492-6	2003	The four groups of mice receiving B16LuF1 cells treated with each of four gangliosides corresponding to GT1b, GD1b, GD1a or GM1 produced lung metastasis comparable to that of untreated control group.	Gangliosides	74-86	coenzyme Q10A	Mus musculus	124-127
15332492-7	2003	Only remaining two gangliosides which corresponded with standard gangliosides GM2 and GM3 increased metastatic potential of B16LuF1 cells.	Gangliosides	19-31	cytochrome b5 domain containing 2	Mus musculus	78-81
15332492-8	2003	Thus, these results indicated that gangliosides GM2 and GM3 of B16-melanoma cells are definitely associated with metastatic potential of these tumor cells.	Gangliosides	35-47	cytochrome b5 domain containing 2	Mus musculus	48-51
12973826-0	2003	Localization of ganglioside 9-O-acetyl GD3 in point contacts of neuronal growth cones.	Gangliosides	16-27	GRDX	Homo sapiens	39-42
12973826-5	2003	Our observations indicate that 9-O-acetyl GD3 is specifically associated with vinculin and beta1 integrin in point contacts of growth cones, suggesting a possible role for this particular ganglioside in the modulation of these contacts during neurite outgrowth.	Gangliosides	188-199	GRDX	Homo sapiens	42-45
12973826-5	2003	Our observations indicate that 9-O-acetyl GD3 is specifically associated with vinculin and beta1 integrin in point contacts of growth cones, suggesting a possible role for this particular ganglioside in the modulation of these contacts during neurite outgrowth.	Gangliosides	188-199	vinculin	Homo sapiens	78-86
12973826-5	2003	Our observations indicate that 9-O-acetyl GD3 is specifically associated with vinculin and beta1 integrin in point contacts of growth cones, suggesting a possible role for this particular ganglioside in the modulation of these contacts during neurite outgrowth.	Gangliosides	188-199	integrin subunit beta 1	Homo sapiens	91-105
12815061-5	2003	Incubation of isolated mitochondria with MG for a short period of time (5 min), followed by removal of excess free MG, prevented both ganglioside GD3- and Ca2+-induced PTP opening and the ensuing membrane depolarization, swelling, and cytochrome c release.	Gangliosides	134-145	GRDX	Homo sapiens	146-149
12906793-5	2003	Ganglioside and cholesterol expression in neurons of NPC1(-/-)/GalNAcT(+/+), NPC1(-/-)/GalNAcT(-/-), NPC1(+/+)/GalNAcT(-/-), and WT mice was examined in situ by immunocytochemical and histochemical methods.	Gangliosides	0-11	NPC intracellular cholesterol transporter 1	Mus musculus	53-57
12909021-1	2003	The GM2-activator protein (GM2-AP) is a small lysosomal lipid transfer protein essential for the hydrolytic conversion of ganglioside GM2 to GM3 by beta-hexosaminidase A.	Gangliosides	122-133	ganglioside GM2 activator	Homo sapiens	4-25
12909021-1	2003	The GM2-activator protein (GM2-AP) is a small lysosomal lipid transfer protein essential for the hydrolytic conversion of ganglioside GM2 to GM3 by beta-hexosaminidase A.	Gangliosides	122-133	ganglioside GM2 activator	Homo sapiens	27-33
12783488-1	2003	R24, a mouse IgG3 monoclonal antibody (MAb) against ganglioside GD3 (Neu5Acalpha8Neu5Acalpha3Gal beta4Glcbeta1Cer), can block tumor growth as reported in a series of clinical trials in patients with metastatic melanoma.	Gangliosides	52-63	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	13-17
12783488-1	2003	R24, a mouse IgG3 monoclonal antibody (MAb) against ganglioside GD3 (Neu5Acalpha8Neu5Acalpha3Gal beta4Glcbeta1Cer), can block tumor growth as reported in a series of clinical trials in patients with metastatic melanoma.	Gangliosides	52-63	GRDX	Homo sapiens	64-67
12906793-5	2003	Ganglioside and cholesterol expression in neurons of NPC1(-/-)/GalNAcT(+/+), NPC1(-/-)/GalNAcT(-/-), NPC1(+/+)/GalNAcT(-/-), and WT mice was examined in situ by immunocytochemical and histochemical methods.	Gangliosides	0-11	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	63-70
12906793-5	2003	Ganglioside and cholesterol expression in neurons of NPC1(-/-)/GalNAcT(+/+), NPC1(-/-)/GalNAcT(-/-), NPC1(+/+)/GalNAcT(-/-), and WT mice was examined in situ by immunocytochemical and histochemical methods.	Gangliosides	0-11	NPC intracellular cholesterol transporter 1	Mus musculus	77-81
12906793-5	2003	Ganglioside and cholesterol expression in neurons of NPC1(-/-)/GalNAcT(+/+), NPC1(-/-)/GalNAcT(-/-), NPC1(+/+)/GalNAcT(-/-), and WT mice was examined in situ by immunocytochemical and histochemical methods.	Gangliosides	0-11	NPC intracellular cholesterol transporter 1	Mus musculus	77-81
12906793-8	2003	These findings provide a compelling argument that cholesterol sequestration in NPC1-deficient neurons is ganglioside dependent and suggest that the function of NPC1 in these cells may be more closely linked to homeostatic control of GSLs than cholesterol.	Gangliosides	105-116	NPC intracellular cholesterol transporter 1	Mus musculus	79-83
12887594-1	2003	Sandhoff disease is a lysosomal storage disease in which ganglioside GM2 accumulates because of a defective beta-subunit of beta-hexosaminidase.	Gangliosides	57-68	cytochrome b5 domain containing 2	Mus musculus	69-72
12873419-4	2003	Among the synthetic gangliosides, GSC-338 (II3III6-disulfate of iso-GM1b) was surprisingly found to be the most potent MAG binding structure tested to date.	Gangliosides	20-32	myelin associated glycoprotein	Homo sapiens	119-122
12778888-4	2003	We also investigated intracellular signaling (glycosignaling) mediated by endogenous GM1a involved in the neuronal differentiation of PC12 cells using the cholera toxin B subunit (CTB) that specifically binds to ganglioside GM1a.	Gangliosides	212-223	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	155-178
12885402-4	2003	SK-N-DZ cells also differed in ganglioside composition with predominant expression of b-series gangliosides.	Gangliosides	31-42	hedgehog acyltransferase	Homo sapiens	0-4
12885402-4	2003	SK-N-DZ cells also differed in ganglioside composition with predominant expression of b-series gangliosides.	Gangliosides	95-107	hedgehog acyltransferase	Homo sapiens	0-4
12847141-1	2003	GD3, a ganglioside expressed on human melanoma, can be recognized by the humoral immune system.	Gangliosides	7-18	GRDX	Homo sapiens	0-3
12847141-9	2003	This could be a mechanism for NKT cell recognition of tumor gangliosides in CD1- tumors.	Gangliosides	60-72	CD1 antigen complex	Mus musculus	76-79
12668675-10	2003	These results suggested the novel substrate specificity of ST6GalNAc VI, which is responsible for the synthesis of disialyl Lea but not for alpha-series gangliosides in human colon tissues.	Gangliosides	153-165	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	Homo sapiens	59-71
12805216-5	2003	Disruption of the Raftlin gene in the DT40 B-cell line resulted in a marked reduction in the quantity of lipid raft components, including Lyn and ganglioside GM1, while overexpression of Raftlin increased the content of raft protein.	Gangliosides	146-157	raftlin, lipid raft linker 1	Homo sapiens	18-25
12729581-7	2003	Although the interaction of proapoptotic proteins with mitochondria initiates apoptotic pathways, recent data indicate that the mitochondrial trafficking of glycosphingolipids, e.g., ganglioside GD3, induced by apoptotic stimuli is a key event that sets off mitochondrial-dependent apoptotic cascades.	Gangliosides	183-194	GRDX	Homo sapiens	195-198
12758127-1	2003	Galbeta1-3Gal-NAcbeta1-4Gal(3-2alphaNeuAc)beta1-4Glcbeta1-1Cer (GM1) is one of the most extensively investigated gangliosides that plays critical roles in the development and functions of the nervous system.	Gangliosides	113-125	coenzyme Q10A	Mus musculus	64-67
12758127-2	2003	UDP-Gal:betaGlcNAc beta1,3-galactosyltransferase (Gal-T-II) is responsible for synthesis of ganglioside GM1 in the ganglioside biosynthetic pathway.	Gangliosides	92-103	UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6	Mus musculus	50-58
12758127-2	2003	UDP-Gal:betaGlcNAc beta1,3-galactosyltransferase (Gal-T-II) is responsible for synthesis of ganglioside GM1 in the ganglioside biosynthetic pathway.	Gangliosides	92-103	coenzyme Q10A	Mus musculus	104-107
12758127-2	2003	UDP-Gal:betaGlcNAc beta1,3-galactosyltransferase (Gal-T-II) is responsible for synthesis of ganglioside GM1 in the ganglioside biosynthetic pathway.	Gangliosides	115-126	UDP-Gal:betaGal beta 1,3-galactosyltransferase, polypeptide 6	Mus musculus	50-58
12758127-2	2003	UDP-Gal:betaGlcNAc beta1,3-galactosyltransferase (Gal-T-II) is responsible for synthesis of ganglioside GM1 in the ganglioside biosynthetic pathway.	Gangliosides	115-126	coenzyme Q10A	Mus musculus	104-107
12730204-8	2003	The data indicate that NEU3 indeed participates in the control of insulin signaling, probably via modulation of gangliosides and interaction with Grb2, and that the mice can serve as a valuable model for human insulin-resistant diabetes.	Gangliosides	112-124	neuraminidase 3	Mus musculus	23-27
12730204-8	2003	The data indicate that NEU3 indeed participates in the control of insulin signaling, probably via modulation of gangliosides and interaction with Grb2, and that the mice can serve as a valuable model for human insulin-resistant diabetes.	Gangliosides	112-124	insulin	Homo sapiens	66-73
12901230-1	2003	GD3, a ganglioside expressed on tumors of neuroectodermal origin such as melanoma and small-cell lung carcinoma (SCLC), is an attractive vaccine target but is poorly immunogenic.	Gangliosides	7-18	GRDX	Homo sapiens	0-3
12778482-0	2003	Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms.	Gangliosides	0-11	sialic acid binding Ig like lectin 7	Homo sapiens	81-89
12803920-4	2003	Furthermore, protein crystals were obtained from soluble recombinant CD1b/beta(2)m-proteins loaded either with phosphatidylinositol or ganglioside GM2, which led to the first atomic structure determination of a CD1/lipid complex.	Gangliosides	135-146	CD1b molecule	Homo sapiens	69-73
12803920-4	2003	Furthermore, protein crystals were obtained from soluble recombinant CD1b/beta(2)m-proteins loaded either with phosphatidylinositol or ganglioside GM2, which led to the first atomic structure determination of a CD1/lipid complex.	Gangliosides	135-146	CD1b molecule	Homo sapiens	69-72
12760286-1	2003	In the GM2 gangliosidosis B1 variant, the mutated isoenzyme A of beta-hexosaminidase (Hex) is incapable of hydrolyzing ganglioside GM2 and negatively charged substrates.	Gangliosides	119-130	O-GlcNAcase	Homo sapiens	65-84
12760286-1	2003	In the GM2 gangliosidosis B1 variant, the mutated isoenzyme A of beta-hexosaminidase (Hex) is incapable of hydrolyzing ganglioside GM2 and negatively charged substrates.	Gangliosides	119-130	O-GlcNAcase	Homo sapiens	86-89
12778888-4	2003	We also investigated intracellular signaling (glycosignaling) mediated by endogenous GM1a involved in the neuronal differentiation of PC12 cells using the cholera toxin B subunit (CTB) that specifically binds to ganglioside GM1a.	Gangliosides	212-223	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	180-183
12778888-6	2003	Biochemical analyses demonstrated that the tyrosine phosphorylation induced by CTB was responsible for neuron-like differentiation of PC12 cells and that the MEK-ERK cascade is a part of the biological signals mediated by endogenous ganglioside GM1a on PC12 cells.	Gangliosides	233-244	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	79-82
12778888-6	2003	Biochemical analyses demonstrated that the tyrosine phosphorylation induced by CTB was responsible for neuron-like differentiation of PC12 cells and that the MEK-ERK cascade is a part of the biological signals mediated by endogenous ganglioside GM1a on PC12 cells.	Gangliosides	233-244	Eph receptor B1	Rattus norvegicus	162-165
12659848-5	2003	These results suggest that the lipid raft containing a ganglioside cluster serves as a conformational catalyst or a chaperon generating a membrane-active form of A beta with seeding ability.	Gangliosides	55-66	amyloid beta precursor protein	Homo sapiens	162-168
12681511-0	2003	Engagement of CD99 triggers the exocytic transport of ganglioside GM1 and the reorganization of actin cytoskeleton.	Gangliosides	54-65	CD99 molecule (Xg blood group)	Homo sapiens	14-18
12680755-1	2003	Employing atomic force microscopy as an in situ molecular force probe, we have measured the binding strength between cholera toxin B-pentamer (ctB) and its membrane receptor, ganglioside G(M1).	Gangliosides	175-186	phosphate cytidylyltransferase 1B, choline	Homo sapiens	117-141
12680755-1	2003	Employing atomic force microscopy as an in situ molecular force probe, we have measured the binding strength between cholera toxin B-pentamer (ctB) and its membrane receptor, ganglioside G(M1).	Gangliosides	175-186	phosphate cytidylyltransferase 1B, choline	Homo sapiens	143-146
12662933-3	2003	Interest in human beta-hexosaminidase stems from its association with Tay-Sachs and Sandhoff disease; these are prototypical lysosomal storage disorders resulting from the abnormal accumulation of G(M2)-ganglioside (G(M2)).	Gangliosides	203-214	O-GlcNAcase	Homo sapiens	18-37
12662933-4	2003	Hex A degrades G(M2) by removing a terminal N-acetyl-D-galactosamine (beta-GalNAc) residue, and this activity requires the G(M2)-activator, a protein which solubilizes the ganglioside for presentation to Hex A.	Gangliosides	172-183	hexosaminidase subunit alpha	Homo sapiens	0-5
12662933-6	2003	From these, and the known X-ray structure of the G(M2)-activator, we have modeled Hex A in complex with the activator and ganglioside.	Gangliosides	122-133	hexosaminidase subunit alpha	Homo sapiens	82-87
12659848-2	2003	We have proposed that the aggregation proceeds in the lipid raft containing a ganglioside cluster, the formation of which is facilitated by cholesterol and for which A beta shows a specific affinity.	Gangliosides	78-89	amyloid beta precursor protein	Homo sapiens	166-172
12794304-0	2003	Domain-dependent modulation of PDGFRbeta by ganglioside GM1.	Gangliosides	44-55	platelet derived growth factor receptor, beta polypeptide	Mus musculus	31-40
15041894-6	2003	Key components of TNF signaling include sphingolipids, particularly ceramide generated from acidic sphingomyelinase activation serving as a source for gangliosides.	Gangliosides	151-163	tumor necrosis factor	Homo sapiens	18-21
12641744-0	2003	The adhesion protein TAG-1 has a ganglioside environment in the sphingolipid-enriched membrane domains of neuronal cells in culture.	Gangliosides	33-44	contactin 2	Homo sapiens	21-26
12641744-7	2003	The three gangliosides bear different oligosaccharide chains, suggesting that the ganglioside/TAG-1 interaction is not specifically associated with the ganglioside oligosaccharide structure.	Gangliosides	10-22	contactin 2	Homo sapiens	94-99
12641744-7	2003	The three gangliosides bear different oligosaccharide chains, suggesting that the ganglioside/TAG-1 interaction is not specifically associated with the ganglioside oligosaccharide structure.	Gangliosides	10-21	contactin 2	Homo sapiens	94-99
12641744-7	2003	The three gangliosides bear different oligosaccharide chains, suggesting that the ganglioside/TAG-1 interaction is not specifically associated with the ganglioside oligosaccharide structure.	Gangliosides	82-93	contactin 2	Homo sapiens	94-99
12670922-8	2003	The ganglioside-synthesizing SK-RC-45 line stimulated the TUNEL (terminal deoxynucleotidyl transferase-mediated nick end labeling) positivity of cocultured T cells by a mechanism that involved decreasing lymphocyte expression levels of Bcl-2 and Bcl-(XL), inducing cytochrome c release from their mitochondria and activating caspases 9 and 3.	Gangliosides	4-15	BCL2 apoptosis regulator	Homo sapiens	236-241
12670922-8	2003	The ganglioside-synthesizing SK-RC-45 line stimulated the TUNEL (terminal deoxynucleotidyl transferase-mediated nick end labeling) positivity of cocultured T cells by a mechanism that involved decreasing lymphocyte expression levels of Bcl-2 and Bcl-(XL), inducing cytochrome c release from their mitochondria and activating caspases 9 and 3.	Gangliosides	4-15	BCL2 like 1	Homo sapiens	246-254
12670922-8	2003	The ganglioside-synthesizing SK-RC-45 line stimulated the TUNEL (terminal deoxynucleotidyl transferase-mediated nick end labeling) positivity of cocultured T cells by a mechanism that involved decreasing lymphocyte expression levels of Bcl-2 and Bcl-(XL), inducing cytochrome c release from their mitochondria and activating caspases 9 and 3.	Gangliosides	4-15	cytochrome c, somatic	Homo sapiens	265-277
12670922-8	2003	The ganglioside-synthesizing SK-RC-45 line stimulated the TUNEL (terminal deoxynucleotidyl transferase-mediated nick end labeling) positivity of cocultured T cells by a mechanism that involved decreasing lymphocyte expression levels of Bcl-2 and Bcl-(XL), inducing cytochrome c release from their mitochondria and activating caspases 9 and 3.	Gangliosides	4-15	caspase 9	Homo sapiens	325-341
12646609-4	2003	At concentrations close to those detected in the sera from melanoma patients, both gangliosides dose-dependently inhibit the phenotypic and functional differentiation of MoDC, as assessed by a strong down-regulation of CD1a, CD54, CD80, and CD40 Ags and impaired allostimulatory function on day 6 of culture.	Gangliosides	83-95	CD1a molecule	Homo sapiens	219-223
12646609-4	2003	At concentrations close to those detected in the sera from melanoma patients, both gangliosides dose-dependently inhibit the phenotypic and functional differentiation of MoDC, as assessed by a strong down-regulation of CD1a, CD54, CD80, and CD40 Ags and impaired allostimulatory function on day 6 of culture.	Gangliosides	83-95	intercellular adhesion molecule 1	Homo sapiens	225-229
12646609-4	2003	At concentrations close to those detected in the sera from melanoma patients, both gangliosides dose-dependently inhibit the phenotypic and functional differentiation of MoDC, as assessed by a strong down-regulation of CD1a, CD54, CD80, and CD40 Ags and impaired allostimulatory function on day 6 of culture.	Gangliosides	83-95	CD80 molecule	Homo sapiens	231-235
12646609-4	2003	At concentrations close to those detected in the sera from melanoma patients, both gangliosides dose-dependently inhibit the phenotypic and functional differentiation of MoDC, as assessed by a strong down-regulation of CD1a, CD54, CD80, and CD40 Ags and impaired allostimulatory function on day 6 of culture.	Gangliosides	83-95	CD40 molecule	Homo sapiens	241-245
12687620-5	2003	The ganglioside GM1 colocalized on the plasma membrane with the raft markers flotillin 1 and 2, which were enriched in low buoyant density fractions containing 52 identifiable proteins, 28 of which have not been reported in rafts, and nine of which are associated with the endoplasmic reticulum (ER).	Gangliosides	4-15	flotillin 1	Homo sapiens	77-94
12629211-0	2003	Enhanced insulin sensitivity in mice lacking ganglioside GM3.	Gangliosides	45-56	granulocyte macrophage antigen 3	Mus musculus	57-60
12635116-2	2003	A previous report on a patient who had a neuropathy with immunoglobulin M (IgM) M-protein binding to a conformational epitope formed by phosphatidic acid (PA) and gangliosides prompted us to investigate the binding of IgG antibodies in GBS sera to a mixture of GM1 and PA (GM1/PA).	Gangliosides	163-175	myomesin 2	Homo sapiens	80-89
12668106-2	2003	The suitably protected lactotriose (Lc3) derivatives were successively glycosylated with sialic acid, sialyl-alpha-(2-->3)-D-galactose and/or L-fucose donors in a regio- and stereo-selective manner, to give the protected type I hexa- and hepta-saccharides, respectively, which were then converted to the target gangliosides by the introduction of ceramide and subsequent complete deprotection.	Gangliosides	314-326	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	36-39
12499380-1	2003	Evidence for caspase-8-ganglioside interaction in T cells.	Gangliosides	23-34	caspase 8	Homo sapiens	13-22
12499380-10	2003	These findings strongly suggest a role for gangliosides as structural components of the membrane multimolecular signaling complex involved in CD95/Fas receptor-mediated apoptotic pathway.	Gangliosides	43-55	Fas cell surface death receptor	Homo sapiens	142-146
12637162-0	2003	Phase behavior in multilamellar vesicles of DPPC containing ganglioside GM3 with a C18:1 sphingoid base and a 24:0 acyl chain (GM3(18,24)) observed by X-ray diffraction.	Gangliosides	60-71	granulocyte macrophage antigen 3	Mus musculus	72-75
12637162-0	2003	Phase behavior in multilamellar vesicles of DPPC containing ganglioside GM3 with a C18:1 sphingoid base and a 24:0 acyl chain (GM3(18,24)) observed by X-ray diffraction.	Gangliosides	60-71	granulocyte macrophage antigen 3	Mus musculus	127-130
12703552-2	2003	In a previous study of GalNAc-T(-/-) mice engineered to lack beta1,4-N-acetylgalactos-aminyltransferase (GM2/GD2 synthase) to abolish any, complex gangliosides, we observed the reduction of nerve conduction velocity but did not find any obvious morphological change in the brain.	Gangliosides	147-159	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	61-103
12703552-2	2003	In a previous study of GalNAc-T(-/-) mice engineered to lack beta1,4-N-acetylgalactos-aminyltransferase (GM2/GD2 synthase) to abolish any, complex gangliosides, we observed the reduction of nerve conduction velocity but did not find any obvious morphological change in the brain.	Gangliosides	147-159	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	105-121
12725332-11	2003	Band5 and Band6 gangliosides corresponded with standard gangliosides GM2 and GM3 respectively.	Gangliosides	16-28	granulocyte macrophage antigen 3	Mus musculus	77-80
12639556-4	2003	Siglec-8 demonstrated low affinity to the gangliosides tested compared with other siglecs.	Gangliosides	42-54	sialic acid binding Ig like lectin 8	Homo sapiens	0-8
12631074-11	2003	Shedding of gangliosides from mesangial cells reduced significantly when apoptosis was inhibited by overexpression of antiapoptotic gene, Bcl-XL.	Gangliosides	12-24	BCL2 like 1	Homo sapiens	138-144
12606034-1	2003	In an earlier study, we showed that expressions of GD3, GT1b, and GQ1b gangliosides in P19 embryonic carcinoma (EC) cells were enhanced during their neural differentiation induced by retinoic acid.	Gangliosides	71-83	GRDX	Homo sapiens	51-54
12639556-0	2003	Ganglioside binding pattern of CD33-related siglecs.	Gangliosides	0-11	CD33 molecule	Homo sapiens	31-35
12639556-5	2003	Despite high structural similarity of CD33 related siglecs, they demonstrated different ganglioside selectivity, in particular to the Neu5Acalpha2-8Neu5Ac motif.	Gangliosides	88-99	CD33 molecule	Homo sapiens	38-42
12639556-1	2003	Our study deals with the interaction of CD33 related-siglecs-5,-7,-8,-9,-10 with gangliosides GT1b, GQ1b, GD3, GM2, GM3 and GD1a.	Gangliosides	81-93	CD33 molecule	Homo sapiens	40-44
12639556-1	2003	Our study deals with the interaction of CD33 related-siglecs-5,-7,-8,-9,-10 with gangliosides GT1b, GQ1b, GD3, GM2, GM3 and GD1a.	Gangliosides	81-93	GRDX	Homo sapiens	106-109
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	Gangliosides	43-55	sialic acid binding Ig like lectin 7	Homo sapiens	0-8
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	Gangliosides	43-55	sialic acid binding Ig like lectin 9	Homo sapiens	13-21
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	Gangliosides	43-55	GRDX	Homo sapiens	56-59
12455030-0	2003	Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene.	Gangliosides	87-98	SYF2 homolog, RNA splicing factor (S. cerevisiae)	Mus musculus	58-61
12639556-3	2003	Siglec-7 and siglec-9 displayed binding to gangliosides GD3, GQ1b and GT1b bearing a disialoside motif, though siglec-7 was more potent; besides, siglec-9 interacted also with GM3.	Gangliosides	43-55	sialic acid binding Ig like lectin 9	Homo sapiens	146-154
12630950-0	2003	Expressional changes of ganglioside GM3 during ovarian maturation and early embryonic development in db/db mice.	Gangliosides	24-35	granulocyte macrophage antigen 3	Mus musculus	36-39
12630950-8	2003	Taken together, the results of this study indicate decreased GM3 expression during ovarian maturation and embryonic development of db/db mice, suggesting that alteration of ganglioside expression induced by the diabetic condition may be implicated in the abnormal follicular embryonic development.	Gangliosides	173-184	granulocyte macrophage antigen 3	Mus musculus	61-64
12455030-0	2003	Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene.	Gangliosides	87-98	cytochrome b5 domain containing 2	Mus musculus	99-102
12455030-1	2003	Ganglioside functions in tumor metastasis were analyzed by carbohydrate remodeling of a mouse Lewis lung cancer (subline P29) by introducing beta1,4GalNAc-T cDNA.	Gangliosides	0-11	SYF2 homolog, RNA splicing factor (S. cerevisiae)	Mus musculus	121-124
12455030-1	2003	Ganglioside functions in tumor metastasis were analyzed by carbohydrate remodeling of a mouse Lewis lung cancer (subline P29) by introducing beta1,4GalNAc-T cDNA.	Gangliosides	0-11	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	141-156
12388556-0	2002	Gangliosides activate Trk receptors by inducing the release of neurotrophins.	Gangliosides	0-12	neurotrophic receptor tyrosine kinase 1	Homo sapiens	22-25
12849750-5	2003	Thus, the cytosolic Ca2+ elevation by the gangliosides may trigger the CaM-KII activation.	Gangliosides	42-54	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	71-78
12849750-8	2003	A small G-protein cdc42 was a potential downstream target of CaM-KII activated by the gangliosides.	Gangliosides	86-98	cell division cycle 42	Mus musculus	18-23
12849750-8	2003	A small G-protein cdc42 was a potential downstream target of CaM-KII activated by the gangliosides.	Gangliosides	86-98	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	61-68
12849750-9	2003	These results suggest that oligosaccharides of the gangliosides serve as potential regulators of the filopodia formation in neuronal cells by triggering the activation of CaM-KII followed by cdc42 up-regulation via a cell surface receptor-like component.	Gangliosides	51-63	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	171-178
12849750-9	2003	These results suggest that oligosaccharides of the gangliosides serve as potential regulators of the filopodia formation in neuronal cells by triggering the activation of CaM-KII followed by cdc42 up-regulation via a cell surface receptor-like component.	Gangliosides	51-63	cell division cycle 42	Mus musculus	191-196
12849750-12	2003	Thus, the ganglioside/CaM-KII signal plays a role in modulating dendritic morphogenesis by inducing cdc42-mediated actin reorganization.	Gangliosides	10-21	calcium/calmodulin-dependent protein kinase II gamma	Mus musculus	22-29
12849750-12	2003	Thus, the ganglioside/CaM-KII signal plays a role in modulating dendritic morphogenesis by inducing cdc42-mediated actin reorganization.	Gangliosides	10-21	cell division cycle 42	Mus musculus	100-105
12388556-14	2002	Our data show that gangliosides may activate different Trk receptors by differentially affecting the release of neurotrophins.	Gangliosides	19-31	neurotrophic receptor tyrosine kinase 1	Homo sapiens	55-58
14579585-0	2003	Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38.	Gangliosides	8-20	CD38 molecule	Homo sapiens	84-88
12531551-3	2002	Known for many years as a branch point enzyme directing synthesis of cerebrosides and gangliosides, GCS has recently been implicated in the cytotoxic response of cancer cells to chemotherapy.	Gangliosides	86-98	UDP-glucose ceramide glucosyltransferase	Homo sapiens	100-103
12531552-2	2002	In mammalian cells, the intracellular accumulation of ganglioside GD3, an acidic glycosphingolipid, contributes to mitochondrial damage, a crucial event during the apoptopic program.	Gangliosides	54-65	GRDX	Homo sapiens	66-69
12531552-3	2002	GD3 is a minor ganglioside in most normal tissues.	Gangliosides	15-26	GRDX	Homo sapiens	0-3
12497591-4	2002	We later modified the procedure to a more clinically applicable "lysed whole blood" CD45(-)CD56(very bright+) ganglioside GD2(+) cocktail to improve turnaround time (eliminating the cell permeabilization step for cytoplasmic NSE analysis), specificity, and sensitivity of the assay.	Gangliosides	110-121	neural cell adhesion molecule 1	Homo sapiens	91-95
12417418-0	2002	Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides.	Gangliosides	125-137	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	0-41
12417418-0	2002	Beta1,4-N-acetylgalactosaminyltransferase--GM2/GD2 synthase: a key enzyme to control the synthesis of brain-enriched complex gangliosides.	Gangliosides	125-137	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	43-59
12354760-0	2002	Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor.	Gangliosides	0-11	caveolin 1	Homo sapiens	20-30
12354760-0	2002	Ganglioside induces caveolin-1 redistribution and interaction with the epidermal growth factor receptor.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	71-103
12354760-6	2002	Consistently, depletion of ganglioside both increases EGFR phosphorylation and prevents the EGF-induced tyrosine phosphorylation of caveolin-1.	Gangliosides	27-38	epidermal growth factor receptor	Homo sapiens	54-58
12354760-2	2002	Ganglioside GM3 inhibits EGFR autophosphorylation and may thus affect the interaction of caveolin-1 and the EGFR.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	25-29
12354760-6	2002	Consistently, depletion of ganglioside both increases EGFR phosphorylation and prevents the EGF-induced tyrosine phosphorylation of caveolin-1.	Gangliosides	27-38	caveolin 1	Homo sapiens	132-142
12354760-2	2002	Ganglioside GM3 inhibits EGFR autophosphorylation and may thus affect the interaction of caveolin-1 and the EGFR.	Gangliosides	0-11	caveolin 1	Homo sapiens	89-99
12354760-2	2002	Ganglioside GM3 inhibits EGFR autophosphorylation and may thus affect the interaction of caveolin-1 and the EGFR.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	108-112
12354760-4	2002	Overexpression of GM3 does not affect EGFR distribution but shifts caveolin-1 to the detergent-soluble, EGFR-containing region; consistently, caveolin-1 is retained in the detergent-insoluble membrane when ganglioside is depleted.	Gangliosides	206-217	caveolin 1	Homo sapiens	142-152
12438625-8	2002	We also demonstrate that VLP bound to specific glycolipids, such as lactosylceramide, and gangliosides, including GM3, GD2, GD3, GD1b, GT1b, and GQ1b, and that VLP bound weakly to GD1a but did not bind to GM1a, GM2, or galactocerebroside.	Gangliosides	90-102	VHL like	Homo sapiens	25-28
12452834-7	2002	The expression of MHC class II molecules, co-stimulatory molecules and the GM-CSF receptor (CD116) on the ganglioside-treated DC was significantly reduced.	Gangliosides	106-117	colony stimulating factor 2 receptor subunit alpha	Homo sapiens	92-97
12351644-0	2002	Ganglioside GD3 sensitizes human hepatoma cells to cancer therapy.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
12351644-1	2002	Ganglioside GD3 (GD3) has emerged as a modulator of cell death pathways due to its ability to interact with mitochondria and disable survival pathways.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
12351644-1	2002	Ganglioside GD3 (GD3) has emerged as a modulator of cell death pathways due to its ability to interact with mitochondria and disable survival pathways.	Gangliosides	0-11	GRDX	Homo sapiens	17-20
12657247-8	2002	Furthermore, ganglioside-exposed DC also evidenced a broad down-regulation of the cytokine release that is normally initiated by LPS exposure, i.e., there was no increase in IL-1 beta, IL-6, IL-10, IL-12, or tumor necrosis factor (TNF)-alpha release.	Gangliosides	13-24	tumor necrosis factor	Homo sapiens	208-241
12454318-3	2002	The first insights were provided when a reduction in cell proliferation in the presence of gangliosides was attributed to inhibition of the epidermal growth factor receptor (EGFR).	Gangliosides	91-103	epidermal growth factor receptor	Homo sapiens	140-172
12454318-3	2002	The first insights were provided when a reduction in cell proliferation in the presence of gangliosides was attributed to inhibition of the epidermal growth factor receptor (EGFR).	Gangliosides	91-103	epidermal growth factor receptor	Homo sapiens	174-178
12183467-1	2002	Gangliosides are implicated in regulating cell adhesion and migration on fibronectin by binding with the alpha(5) subunit of alpha(5)beta(1) integrin.	Gangliosides	0-12	fibronectin 1	Homo sapiens	73-84
12191995-5	2002	Consistent with this, gangliosides rapidly activated JAK1 and JAK2 and induced phosphorylation of STAT1 and STAT3.	Gangliosides	22-34	Janus kinase 1	Rattus norvegicus	53-57
12512955-6	2002	These cells were exposed to three different inhibitors of glucosylceramide synthase, the first enzyme committed for the biosynthesis of most of the brain gangliosides.	Gangliosides	154-166	UDP-glucose ceramide glucosyltransferase	Homo sapiens	58-83
12183467-3	2002	Increases in gangliosides GT1b and GD3 inhibited spreading on fibronectin, concurrent with inhibition of Src and focal adhesion kinase.	Gangliosides	13-25	fibronectin 1	Homo sapiens	62-73
12191995-5	2002	Consistent with this, gangliosides rapidly activated JAK1 and JAK2 and induced phosphorylation of STAT1 and STAT3.	Gangliosides	22-34	Janus kinase 2	Rattus norvegicus	62-66
12183467-4	2002	Although antibody blockade of GT1b or GD3 function and gene-modulated ganglioside depletion stimulated spreading and activated Src and focal adhesion kinase, the augmented spreading by disruption of GT1b function, but not by disruption of GD3 function, was inhibited by blockade of Src and focal adhesion kinase activation.	Gangliosides	70-81	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	127-130
12191995-5	2002	Consistent with this, gangliosides rapidly activated JAK1 and JAK2 and induced phosphorylation of STAT1 and STAT3.	Gangliosides	22-34	signal transducer and activator of transcription 1	Rattus norvegicus	98-103
12191995-5	2002	Consistent with this, gangliosides rapidly activated JAK1 and JAK2 and induced phosphorylation of STAT1 and STAT3.	Gangliosides	22-34	signal transducer and activator of transcription 3	Rattus norvegicus	108-113
12183467-6	2002	Modulation of either GT1b or GD3 content affected phosphoinositol 3-kinase activation, and inhibition of this activation reversed the stimulation of cell spreading by anti-GD3 antibody, anti-GT1b antibody, and ganglioside depletion, suggesting that phosphoinositol 3-kinase is an intermediate in both the FAK/Src and protein kinase C pathways that lead to cell spreading.	Gangliosides	210-221	GRDX	Homo sapiens	29-32
12191995-6	2002	In addition, gangliosides increased transcription of the inflammation-associated genes inducible nitric-oxide synthase, ICAM-1, and MCP-1, which are reported to contain STAT-binding elements in their promoter regions.	Gangliosides	13-25	intercellular adhesion molecule 1	Rattus norvegicus	120-126
12183467-6	2002	Modulation of either GT1b or GD3 content affected phosphoinositol 3-kinase activation, and inhibition of this activation reversed the stimulation of cell spreading by anti-GD3 antibody, anti-GT1b antibody, and ganglioside depletion, suggesting that phosphoinositol 3-kinase is an intermediate in both the FAK/Src and protein kinase C pathways that lead to cell spreading.	Gangliosides	210-221	protein tyrosine kinase 2	Homo sapiens	305-308
12183467-6	2002	Modulation of either GT1b or GD3 content affected phosphoinositol 3-kinase activation, and inhibition of this activation reversed the stimulation of cell spreading by anti-GD3 antibody, anti-GT1b antibody, and ganglioside depletion, suggesting that phosphoinositol 3-kinase is an intermediate in both the FAK/Src and protein kinase C pathways that lead to cell spreading.	Gangliosides	210-221	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	309-312
12191995-6	2002	In addition, gangliosides increased transcription of the inflammation-associated genes inducible nitric-oxide synthase, ICAM-1, and MCP-1, which are reported to contain STAT-binding elements in their promoter regions.	Gangliosides	13-25	mast cell protease 1-like 1	Rattus norvegicus	132-137
12191995-7	2002	AG490, a JAK inhibitor, reduced induction of these genes, nuclear factor binding activity, and activation of STAT1 and -3 in gangliosides-treated microglia.	Gangliosides	125-137	signal transducer and activator of transcription 1	Rattus norvegicus	109-121
12183467-7	2002	These studies demonstrate that epithelial cell ganglioside GT1b modulates cell spreading through alpha(5)beta(1)/FAK and phosphoinositol 3-kinase signaling, whereas GD3-modulated spreading appears to involve phosphoinositol 3-kinase-dependent protein kinase C signaling.	Gangliosides	47-58	protein tyrosine kinase 2	Homo sapiens	113-116
12393190-1	2002	GM3 synthase, which transfers CMP-NeuAc with an alpha2,3-linkage to a galactose residue of lactosylceramide, plays a key role in the biosynthesis of all complex gangliosides.	Gangliosides	161-173	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
12118012-0	2002	Trafficking of ganglioside GD3 to mitochondria by tumor necrosis factor-alpha.	Gangliosides	15-26	tumor necrosis factor	Rattus norvegicus	50-77
12239168-8	2002	The ganglioside GM1, a marker of rafts, was augmented in TCR-stimulated but not IL-7-stimulated T lymphocytes, and disruption of rafts inhibited gp120-induced signaling.	Gangliosides	4-15	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	57-60
12470841-2	2002	In mammalian cells, the intracellular accumulation of ganglioside GD3, an acidic glycosphingolipid, contributes to mitochondrial damage, a crucial event during the apoptotic program.	Gangliosides	54-65	GRDX	Homo sapiens	66-69
12470841-3	2002	GD3 is a minor ganglioside in most normal tissues.	Gangliosides	15-26	GRDX	Homo sapiens	0-3
12234191-1	2002	Three key regulatory enzymes in ganglioside biosynthesis, sialyltransferase I (ST1), sialyltransferase II (ST2), and N-acetylgalactosaminyltransferase I (GalNAcT), have been expressed as fusion proteins with green, yellow, or red fluorescent protein (GFP, YFP, or RFP) in F-11A cells.	Gangliosides	32-43	interleukin 1 receptor-like 1	Mus musculus	107-110
12234191-1	2002	Three key regulatory enzymes in ganglioside biosynthesis, sialyltransferase I (ST1), sialyltransferase II (ST2), and N-acetylgalactosaminyltransferase I (GalNAcT), have been expressed as fusion proteins with green, yellow, or red fluorescent protein (GFP, YFP, or RFP) in F-11A cells.	Gangliosides	32-43	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	154-161
12234191-1	2002	Three key regulatory enzymes in ganglioside biosynthesis, sialyltransferase I (ST1), sialyltransferase II (ST2), and N-acetylgalactosaminyltransferase I (GalNAcT), have been expressed as fusion proteins with green, yellow, or red fluorescent protein (GFP, YFP, or RFP) in F-11A cells.	Gangliosides	32-43	tripartite motif-containing 27	Mus musculus	264-267
12234191-5	2002	Untransfected F-11A cells contain mainly GM3, whereas stable transfection with ST2 or GalNAcT results in the predominant expression of b-series complex gangliosides (BCGs).	Gangliosides	152-164	interleukin 1 receptor-like 1	Mus musculus	79-82
12234191-5	2002	Untransfected F-11A cells contain mainly GM3, whereas stable transfection with ST2 or GalNAcT results in the predominant expression of b-series complex gangliosides (BCGs).	Gangliosides	152-164	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	86-93
12208520-1	2002	Possible role of ganglioside GD3.	Gangliosides	17-28	GRDX	Homo sapiens	29-32
12183547-7	2002	In GalNAc transferase knockout mice that lack all complex gangliosides and instead express high levels of GM3 and GD3, generation of anti-ganglioside antibodies upon immunization with either complex gangliosides or ganglioside-mimicking LPS is greatly enhanced and exhibits class switching to T-cell-dependent IgG isotypes and immunological memory, indicating that tolerance to self gangliosides is a major regulatory factor.	Gangliosides	138-149	granulocyte macrophage antigen 3	Mus musculus	106-109
12089155-0	2002	Botulinum neurotoxin A activity is dependent upon the presence of specific gangliosides in neuroblastoma cells expressing synaptotagmin I.	Gangliosides	75-87	synaptotagmin 1	Homo sapiens	122-137
12149448-1	2002	Human plasma membrane-associated sialidase (Neu3) is unique in specifically hydrolyzing gangliosides, thought to participate in cell differentiation and transmembrane signaling, thereby playing crucial roles in the regulation of cell surface functions.	Gangliosides	88-100	neuraminidase 3	Homo sapiens	13-48
12177185-2	2002	We tested this hypothesis directly by studying neuromuscular synapses of mice lacking complex gangliosides attributable to deletion of the gene coding for beta1,4 GalNAc-transferase (GM2/GD2 synthase), which catalyzes an early step in ganglioside synthesis.	Gangliosides	94-106	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	183-199
12177185-2	2002	We tested this hypothesis directly by studying neuromuscular synapses of mice lacking complex gangliosides attributable to deletion of the gene coding for beta1,4 GalNAc-transferase (GM2/GD2 synthase), which catalyzes an early step in ganglioside synthesis.	Gangliosides	94-105	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	183-199
12374216-1	2002	Previous studies from this laboratory and others have suggested the evidences that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	Gangliosides	109-120	coenzyme Q10A	Mus musculus	121-124
12145186-0	2002	Novel carbohydrate specificity of the 16-kDa galectin from Caenorhabditis elegans: binding to blood group precursor oligosaccharides (type 1, type 2, Talpha, and Tbeta) and gangliosides.	Gangliosides	173-185	Galectin	Caenorhabditis elegans	45-53
12145189-8	2002	Quantification of the predominant receptor ganglioside IV(6)Neu5Ac-nLc4Cer by means of a specific anti-Neu5Acalpha2-6Galbeta1-4GlcNAc-R antibody revealed 3.68 x 10(6) and 1.54 x 10(6) receptor molecules per HL-60 and 5637 cell, respectively; CHO-K1 cells were negative, lacking alpha2-6-sialylated gangliosides.	Gangliosides	43-54	immunoglobulin binding protein 1	Homo sapiens	109-117
12145192-0	2002	Inhibition of EGF-mediated receptor activity and cell proliferation by HK1-ceramide, a stable analog of the ganglioside GM3-lactone.	Gangliosides	108-119	hexokinase 1	Homo sapiens	71-74
12177178-2	2002	A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides on C18 silica gel could be used with the copolymer.	Gangliosides	101-113	Bardet-Biedl syndrome 9	Homo sapiens	36-39
12177178-2	2002	A comparison with octadecyl-bonded (C18) silica gel showed that the general procedure used to purify gangliosides on C18 silica gel could be used with the copolymer.	Gangliosides	101-113	Bardet-Biedl syndrome 9	Homo sapiens	117-120
12374221-1	2002	Plasma membrane-associated sialidase (Neu 3), which specifically hydrolyzes gangliosides, is relatively abundantly present in the nervous system.	Gangliosides	76-88	neuraminidase 3	Homo sapiens	0-43
12130682-7	2002	P-gp function was found to be stimulated only by the addition of gangliosides in all resistant cell lines, whereas Glu-Cer, Lac-Cer, and Cer had no effect.	Gangliosides	65-77	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
12130682-9	2002	Altogether, these results suggest that, at least in leukemic cells, gangliosides depletion accounts for PDMP-mediated MDR reversal effect, and that gangliosides are important P-gp regulators perhaps through their capacity to modulate P-gp phosphorylation.	Gangliosides	148-160	ATP binding cassette subfamily B member 1	Homo sapiens	175-179
12130682-9	2002	Altogether, these results suggest that, at least in leukemic cells, gangliosides depletion accounts for PDMP-mediated MDR reversal effect, and that gangliosides are important P-gp regulators perhaps through their capacity to modulate P-gp phosphorylation.	Gangliosides	148-160	ATP binding cassette subfamily B member 1	Homo sapiens	234-238
12374211-0	2002	Influence of gangliosides on the IL-2- and IL-4-dependent cell proliferation.	Gangliosides	13-25	interleukin 2	Mus musculus	33-47
12374211-1	2002	Ganglioside-induced apoptosis in the cells of IL-2-dependent cytotoxic murine cell line CTLL-2 was shown to be caspase dependent: GM1-, GM2-, and GD3-induced suppression of cell proliferation was cancelled by a general caspase inhibitor Z-VAD-FMK.	Gangliosides	0-11	interleukin 2	Mus musculus	46-50
12374211-1	2002	Ganglioside-induced apoptosis in the cells of IL-2-dependent cytotoxic murine cell line CTLL-2 was shown to be caspase dependent: GM1-, GM2-, and GD3-induced suppression of cell proliferation was cancelled by a general caspase inhibitor Z-VAD-FMK.	Gangliosides	0-11	caspase 1	Mus musculus	111-118
12374211-1	2002	Ganglioside-induced apoptosis in the cells of IL-2-dependent cytotoxic murine cell line CTLL-2 was shown to be caspase dependent: GM1-, GM2-, and GD3-induced suppression of cell proliferation was cancelled by a general caspase inhibitor Z-VAD-FMK.	Gangliosides	0-11	caspase 1	Mus musculus	219-226
12374216-1	2002	Previous studies from this laboratory and others have suggested the evidences that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	Gangliosides	109-120	coenzyme Q10A	Mus musculus	126-129
12374211-2	2002	Ganglioside-induced apoptosis pathways are different for different individual glycolipids; the differences exist both at the initiation and effector stages of the caspase cascade.	Gangliosides	0-11	caspase 1	Mus musculus	163-170
12374216-1	2002	Previous studies from this laboratory and others have suggested the evidences that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	Gangliosides	109-120	trunk	Drosophila melanogaster	206-209
12374216-1	2002	Previous studies from this laboratory and others have suggested the evidences that acidic glycosphingolipid, ganglioside GM1 (GM1), is an endogenous regulator of high affinity nerve growth factor receptor, Trk, which is an essential factor for the normal development and differentiation of neuronal cells by forming a complex with Trk.	Gangliosides	109-120	trunk	Drosophila melanogaster	331-334
12060784-0	2002	Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration.	Gangliosides	0-12	myelin-associated glycoprotein	Rattus norvegicus	51-81
12011038-0	2002	A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains.	Gangliosides	27-38	neuraminidase 3	Homo sapiens	58-62
12011038-1	2002	The ganglioside-specific sialidase Neu3 has been suggested to play essential roles in regulation of cell surface functions because of its major localization in the plasma membrane and strict substrate preference for gangliosides involved in signal transduction.	Gangliosides	4-15	neuraminidase 3	Homo sapiens	35-39
12011038-1	2002	The ganglioside-specific sialidase Neu3 has been suggested to play essential roles in regulation of cell surface functions because of its major localization in the plasma membrane and strict substrate preference for gangliosides involved in signal transduction.	Gangliosides	216-228	neuraminidase 3	Homo sapiens	35-39
12164932-0	2002	Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signaling.	Gangliosides	0-11	integrin linked kinase	Homo sapiens	59-81
12164932-0	2002	Ganglioside loss promotes survival primarily by activating integrin-linked kinase/Akt without phosphoinositide 3-OH kinase signaling.	Gangliosides	0-11	AKT serine/threonine kinase 1	Homo sapiens	82-85
12164932-3	2002	Ganglioside depletion promotes survival of the human keratinocyte-derived SCC12 cell line through upregulated phosphorylation of beta1 integrin, and increased phosphorylation and activity of integrin-linked kinase, protein kinase B/Akt, and Bad, with resultant inhibition of caspase-9 activation.	Gangliosides	0-11	integrin subunit beta 1	Homo sapiens	129-143
12164932-3	2002	Ganglioside depletion promotes survival of the human keratinocyte-derived SCC12 cell line through upregulated phosphorylation of beta1 integrin, and increased phosphorylation and activity of integrin-linked kinase, protein kinase B/Akt, and Bad, with resultant inhibition of caspase-9 activation.	Gangliosides	0-11	integrin linked kinase	Homo sapiens	191-213
12164932-3	2002	Ganglioside depletion promotes survival of the human keratinocyte-derived SCC12 cell line through upregulated phosphorylation of beta1 integrin, and increased phosphorylation and activity of integrin-linked kinase, protein kinase B/Akt, and Bad, with resultant inhibition of caspase-9 activation.	Gangliosides	0-11	protein tyrosine kinase 2 beta	Homo sapiens	215-231
12164932-3	2002	Ganglioside depletion promotes survival of the human keratinocyte-derived SCC12 cell line through upregulated phosphorylation of beta1 integrin, and increased phosphorylation and activity of integrin-linked kinase, protein kinase B/Akt, and Bad, with resultant inhibition of caspase-9 activation.	Gangliosides	0-11	AKT serine/threonine kinase 1	Homo sapiens	232-235
12164932-3	2002	Ganglioside depletion promotes survival of the human keratinocyte-derived SCC12 cell line through upregulated phosphorylation of beta1 integrin, and increased phosphorylation and activity of integrin-linked kinase, protein kinase B/Akt, and Bad, with resultant inhibition of caspase-9 activation.	Gangliosides	0-11	caspase 9	Homo sapiens	275-284
12164932-4	2002	Ganglioside deficiency also increases expression of cyclins D1 and E, promoting cell cycle progression from G1 phase to S phase.	Gangliosides	0-11	cyclin D1	Homo sapiens	52-68
12164932-5	2002	Inhibition of either protein kinase B/Akt or integrin-linked kinase activity renders the ganglioside-deficient cells susceptible to triggers of apoptosis.	Gangliosides	89-100	protein tyrosine kinase 2 beta	Homo sapiens	21-37
12164932-5	2002	Inhibition of either protein kinase B/Akt or integrin-linked kinase activity renders the ganglioside-deficient cells susceptible to triggers of apoptosis.	Gangliosides	89-100	AKT serine/threonine kinase 1	Homo sapiens	38-41
12164932-5	2002	Inhibition of either protein kinase B/Akt or integrin-linked kinase activity renders the ganglioside-deficient cells susceptible to triggers of apoptosis.	Gangliosides	89-100	integrin linked kinase	Homo sapiens	45-67
12164932-6	2002	Both serine-473 and threonine-308 sites of protein kinase B/Akt show increased phosphorylation in ganglioside-deficient cells, but the cell survival correlates with increased phosphorylation of the serine-473 site of Akt, not with increased phosphorylation of the threonine-308 site.	Gangliosides	98-109	protein tyrosine kinase 2 beta	Homo sapiens	43-59
12164932-6	2002	Both serine-473 and threonine-308 sites of protein kinase B/Akt show increased phosphorylation in ganglioside-deficient cells, but the cell survival correlates with increased phosphorylation of the serine-473 site of Akt, not with increased phosphorylation of the threonine-308 site.	Gangliosides	98-109	AKT serine/threonine kinase 1	Homo sapiens	60-63
12164932-6	2002	Both serine-473 and threonine-308 sites of protein kinase B/Akt show increased phosphorylation in ganglioside-deficient cells, but the cell survival correlates with increased phosphorylation of the serine-473 site of Akt, not with increased phosphorylation of the threonine-308 site.	Gangliosides	98-109	AKT serine/threonine kinase 1	Homo sapiens	217-220
12164932-7	2002	Consistently, blockade of ganglioside GT1b function activates integrin-linked kinase and only the serine-473 site of protein kinase B/Akt.	Gangliosides	26-37	integrin linked kinase	Homo sapiens	62-84
12164932-7	2002	Consistently, blockade of ganglioside GT1b function activates integrin-linked kinase and only the serine-473 site of protein kinase B/Akt.	Gangliosides	26-37	AKT serine/threonine kinase 1	Homo sapiens	134-137
12164932-10	2002	These data suggest that ganglioside depletion modulates cell survival primarily through protein kinase B/Akt stimulation by a pathway that does not require phosphoinositide 3-OH kinase and epidermal growth factor receptor signaling.	Gangliosides	24-35	protein tyrosine kinase 2 beta	Homo sapiens	88-104
12164932-10	2002	These data suggest that ganglioside depletion modulates cell survival primarily through protein kinase B/Akt stimulation by a pathway that does not require phosphoinositide 3-OH kinase and epidermal growth factor receptor signaling.	Gangliosides	24-35	AKT serine/threonine kinase 1	Homo sapiens	105-108
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	35-46	amyloid beta precursor protein	Homo sapiens	119-124
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	35-46	amyloid beta precursor protein	Homo sapiens	153-158
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	35-46	amyloid beta precursor protein	Homo sapiens	153-158
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	135-146	amyloid beta precursor protein	Homo sapiens	119-124
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	135-146	amyloid beta precursor protein	Homo sapiens	153-158
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	135-146	amyloid beta precursor protein	Homo sapiens	153-158
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	135-146	amyloid beta precursor protein	Homo sapiens	119-124
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	135-146	amyloid beta precursor protein	Homo sapiens	153-158
12044171-5	2002	In this study, we investigated the ganglioside species-specificity in its potency to induce a conformational change of Abeta, by which ganglioside-bound Abeta acts as a seed for Abeta fibrillogenesis, using a major ganglioside occurring in brains (GM1, GD1a, GD1b, and GT1b) in raft-like membranes composed of cholesterol and sphingomyelin.	Gangliosides	135-146	amyloid beta precursor protein	Homo sapiens	153-158
12044171-6	2002	Abeta recognized ganglioside clusters, the density of which increased with the number of sialic acid residues.	Gangliosides	17-28	amyloid beta precursor protein	Homo sapiens	0-5
12044171-9	2002	Ganglioside-bound Abeta proteins exhibited seeding abilities for amyloid formation.	Gangliosides	0-11	amyloid beta precursor protein	Homo sapiens	18-23
12027446-2	2002	In addition, HIV particles and nucleolin coaggregate with glycolipid-enriched membrane microdomains (GEMs) containing ganglioside, and glycosylphosphatidylinositol-linked proteins CD90 and CD59, pointing out that HIV anchorage induces lateral assemblies of specific membrane components into lipid rafts in which surface nucleolin is also incorporated.	Gangliosides	118-129	nucleolin	Homo sapiens	31-40
12060784-0	2002	Gangliosides are functional nerve cell ligands for myelin-associated glycoprotein (MAG), an inhibitor of nerve regeneration.	Gangliosides	0-12	myelin-associated glycoprotein	Rattus norvegicus	83-86
12060784-3	2002	We identify the nerve cell surface gangliosides GD1a and GT1b as specific functional ligands for MAG-mediated inhibition of neurite outgrowth from primary rat cerebellar granule neurons.	Gangliosides	35-47	myelin-associated glycoprotein	Rattus norvegicus	97-100
12060784-4	2002	MAG-mediated neurite outgrowth inhibition is attenuated by (i) neuraminidase treatment of the neurons; (ii) blocking neuronal ganglioside biosynthesis; (iii) genetically modifying the terminal structures of nerve cell surface gangliosides; and (iv) adding highly specific IgG-class antiganglioside mAbs.	Gangliosides	126-137	myelin-associated glycoprotein	Rattus norvegicus	0-3
12060784-4	2002	MAG-mediated neurite outgrowth inhibition is attenuated by (i) neuraminidase treatment of the neurons; (ii) blocking neuronal ganglioside biosynthesis; (iii) genetically modifying the terminal structures of nerve cell surface gangliosides; and (iv) adding highly specific IgG-class antiganglioside mAbs.	Gangliosides	226-238	myelin-associated glycoprotein	Rattus norvegicus	0-3
12060784-6	2002	These data implicate the nerve cell surface gangliosides GD1a and GT1b as functional MAG ligands and suggest that the first step in MAG inhibition is multivalent ganglioside clustering.	Gangliosides	44-55	myelin-associated glycoprotein	Rattus norvegicus	85-88
12060784-6	2002	These data implicate the nerve cell surface gangliosides GD1a and GT1b as functional MAG ligands and suggest that the first step in MAG inhibition is multivalent ganglioside clustering.	Gangliosides	44-55	myelin-associated glycoprotein	Rattus norvegicus	132-135
12068067-2	2002	Gangliosides of various types, especially GM1, are known to have a role in some aspects of Ca2+ regulation, operating through a variety of mechanisms that are gradually coming to light.	Gangliosides	0-12	coenzyme Q10A	Mus musculus	42-45
12007140-8	2002	Cells treated with IL-13 plus LPS, or IL-13 plus ganglioside, showed the characteristics of apoptosis when analyzed by electron microscopy and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling staining.	Gangliosides	49-60	interleukin 13	Homo sapiens	38-43
12021313-4	2002	Here, we show that after T cell stimulation, CTLA-4 coclusters with the TCR and the lipid raft ganglioside GM1 within the IS.	Gangliosides	95-106	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	45-51
12115971-8	2002	We conclude that a distinct syndrome of chronic demyelinating neuropathy with sensory ataxia, unresponsive to corticosteroids, is associated with monoclonal IgM binding to gangliosides with a terminal GalNAc(beta1-4)Gal(alpha2-3)NeuAc trisaccharide moiety.	Gangliosides	172-184	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	208-215
11886870-7	2002	We also show by immunofluorescence that in unstimulated cells the EGF receptor is localized in non-caveolar lipid rafts containing the ganglioside GM1 and that patching of these rafts by cholera toxin B-chain causes co-patching of EGF receptors.	Gangliosides	135-146	epidermal growth factor	Homo sapiens	66-69
12011108-7	2002	Ganglioside GT1b, which is one of the binding partners of MAG, specifically associates with p75(NTR).	Gangliosides	0-11	myelin-associated glycoprotein	Mus musculus	58-61
12011108-7	2002	Ganglioside GT1b, which is one of the binding partners of MAG, specifically associates with p75(NTR).	Gangliosides	0-11	nerve growth factor receptor (TNFR superfamily, member 16)	Mus musculus	92-95
12829403-0	2002	Gangliosides prevent excitotoxicity through activation of TrkB receptor.	Gangliosides	0-12	neurotrophic receptor tyrosine kinase 2	Homo sapiens	58-62
12056050-0	2002	[Ganglioside GM3-mediated modulation of insulin resistance in 3T3-L1 adipocytes].	Gangliosides	1-12	insulin	Homo sapiens	40-47
12065629-3	2002	The ability of GM1 to induce pTrk was shared by other gangliosides, and was blocked by the selective Trk kinase inhibitors K252a and AG879.	Gangliosides	54-66	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	30-33
12065629-7	2002	The GM1 effect on Erk2 was mimicked by other gangliosides, and was blocked by the Trk kinase inhibitors K252a and AG879.	Gangliosides	45-57	mitogen activated protein kinase 1	Rattus norvegicus	18-22
11967288-7	2002	Biochemical fractionation and confocal imaging of HIV-1 receptor distribution in live cells demonstrated that CD4, CCR5, and CXCR4 colocalized with raft-resident markers, ganglioside GM1, and glycosylphosphatidylinositol-anchored CD48.	Gangliosides	171-182	CD4 molecule	Homo sapiens	110-113
12829403-3	2002	In these studies, we used primary cultures of cerebellar granule cells to determine whether gangliosides exert neuroprotective effect via the activation of Trk receptors.	Gangliosides	92-104	neurotrophic receptor tyrosine kinase 1	Homo sapiens	156-159
12829403-11	2002	Our data suggest that by activating the Trk neurotrophin receptors, gangliosides may be used as neuroprotective agents.	Gangliosides	68-80	neurotrophic receptor tyrosine kinase 1	Homo sapiens	40-43
12829403-11	2002	Our data suggest that by activating the Trk neurotrophin receptors, gangliosides may be used as neuroprotective agents.	Gangliosides	68-80	brain derived neurotrophic factor	Homo sapiens	44-56
11997124-6	2002	The immunolabeling of two major proteins of myelin (myelin basic protein, proteolipid-DM20) and of 2",3"-cyclic nucleotide 3"-phosphodiesterase shows colocalization with probes partitioning preferentially in liquid-expanded lipid domains also containing ganglioside G(M1).	Gangliosides	254-265	myelin basic protein	Homo sapiens	52-72
11849746-1	2002	Alteration in ganglioside composition in F-11 cells by suppression of GD3-synthase gene expression resulted in greatly reduced tumor growth and metastasis when the cells were injected into nude mice.	Gangliosides	14-25	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	70-82
11952645-14	2002	These data suggest that gangliosides differ in their potency as inhibitors of NBL-W neuroblastoma cell proliferation and EGFR tyrosine phosphorylation, and that perturbations in the differential expression of membrane glycosphingolipids may play a role in modulating neuroblastoma growth.	Gangliosides	24-36	epidermal growth factor receptor	Homo sapiens	121-125
11917140-1	2002	Free gangliosides bind fibroblast growth factor 2 (FGF2), thus preventing cell interaction and biological activity of the growth factor in endothelial cells.	Gangliosides	5-17	fibroblast growth factor 2	Cricetulus griseus	23-49
11917140-1	2002	Free gangliosides bind fibroblast growth factor 2 (FGF2), thus preventing cell interaction and biological activity of the growth factor in endothelial cells.	Gangliosides	5-17	fibroblast growth factor 2	Cricetulus griseus	51-55
11917140-2	2002	Here we investigated the role of cell-associated gangliosides in mediating the biological activity of FGF2.	Gangliosides	49-61	fibroblast growth factor 2	Cricetulus griseus	102-106
11917140-6	2002	125I-FGF2 binds to cell membrane GM1 (K(d) = 3 nM) in complex ganglioside/heparan sulfate-deficient Chinese hamster ovary (CHO)-K1-pgsA745 cell mutants that were overloaded with exogenous GM1.	Gangliosides	62-73	fibroblast growth factor 2	Bos taurus	5-9
11917140-9	2002	Finally, GM1-overloading confers to FGF receptor 1-transfected, complex ganglioside-deficient CHO-K1 cell mutants the capacity to proliferate when stimulated by FGF2.	Gangliosides	72-83	fibroblast growth factor 2	Cricetulus griseus	161-165
11917140-13	2002	Our data indicate that cell-associated gangliosides may act as functional FGF2 co-receptors in different cell types.	Gangliosides	39-51	fibroblast growth factor 2	Cricetulus griseus	74-78
11952645-1	2002	The inhibitory action of gangliosides GT1B, GD1A, GM3 and GM1 on cell proliferation and epidermal growth factor receptor (EGFR) phosphorylation was determined in the N-myc amplified human neuroblastoma cell line NBL-W.	Gangliosides	25-37	Epidermal growth factor receptor	Drosophila melanogaster	88-120
11952645-9	2002	The suppression of EGF-induced EGFR phosphorylation differed for each ganglioside, and their respective inhibitory potencies were as follows: EGFR phosphorylation [area under curve (+ EGF)/area under curve (- EGF)]: control (no ganglioside added) = 8.2; GM1 = 8.3; GD1A = 6.7; GM3 = 4.87, and GT1B = 4.09.	Gangliosides	70-81	epidermal growth factor receptor	Homo sapiens	31-35
11796728-0	2002	Interaction of the extracellular domain of the epidermal growth factor receptor with gangliosides.	Gangliosides	85-97	epidermal growth factor receptor	Homo sapiens	47-79
11982587-0	2002	Ganglioside expression in tissues of mice lacking beta2-microglobulin.	Gangliosides	0-11	beta-2 microglobulin	Mus musculus	50-69
11982587-4	2002	The lungs of the beta2M-/- mice also had reduced expression of T-lymphocyte-specific GM1b-type gangliosides (GM1b and GalNAc-GM1b).	Gangliosides	95-107	beta-2 microglobulin	Mus musculus	17-23
11982587-6	2002	This study provides in vivo evidence that the beta2M molecule can influence the acquisition of a distinct ganglioside assembly in different mouse organs, implicating its non-immunological functions.	Gangliosides	106-117	beta-2 microglobulin	Mus musculus	46-52
11782461-1	2002	To investigate the molecular mechanisms of gangliosides for the regulation of cell proliferation, Swiss 3T3 cells were transfected with GM2/GD2 synthase and GM1 synthase cDNAs, resulting in the establishment of GM1-expressing (GM1(+)) lines.	Gangliosides	43-55	coenzyme Q10A	Mus musculus	211-214
11782461-1	2002	To investigate the molecular mechanisms of gangliosides for the regulation of cell proliferation, Swiss 3T3 cells were transfected with GM2/GD2 synthase and GM1 synthase cDNAs, resulting in the establishment of GM1-expressing (GM1(+)) lines.	Gangliosides	43-55	coenzyme Q10A	Mus musculus	211-214
11796728-5	2002	In this study, the interaction of gangliosides with the extracellular domain (ECD) of the EGFR was investigated.	Gangliosides	34-46	epidermal growth factor receptor	Homo sapiens	90-94
11856818-1	2002	Gangliosides such as GD3, GM2, and GD2 are abundantly expressed on the cell surfaces of various malignant cells, suggesting the potential for anti-ganglioside antibody therapy for tumors.	Gangliosides	0-12	GRDX	Homo sapiens	21-24
11796728-8	2002	In agreement with previous reports on the effects of specific gangliosides on EGFR kinase activity, the ECD preferentially interacted with GM3.	Gangliosides	62-74	epidermal growth factor receptor	Homo sapiens	78-82
11796728-9	2002	The order of relative binding of other gangliosides investigated was as follows: GM3 GM2, GD3, GM4 > GM1, GD1a, GD1b, GT1b, GD2, GQ1b > lactosylceramide.	Gangliosides	39-51	GRDX	Homo sapiens	90-93
11796728-12	2002	Identification of a ganglioside interaction site on the ECD of the EGFR is consistent with the hypothesis that endogenous GM3 may function as a direct modulator of EGFR activity.	Gangliosides	20-31	epidermal growth factor receptor	Homo sapiens	67-71
11796728-12	2002	Identification of a ganglioside interaction site on the ECD of the EGFR is consistent with the hypothesis that endogenous GM3 may function as a direct modulator of EGFR activity.	Gangliosides	20-31	epidermal growth factor receptor	Homo sapiens	164-168
11856818-1	2002	Gangliosides such as GD3, GM2, and GD2 are abundantly expressed on the cell surfaces of various malignant cells, suggesting the potential for anti-ganglioside antibody therapy for tumors.	Gangliosides	147-158	GRDX	Homo sapiens	21-24
11971858-4	2002	Antisense transfection inhibited the synthesis of the direct product of glucosylceramide synthase, glucosylceramide, and consequently G(M3) ganglioside, by MEB4 cells, reducing the concentration of G(M3) in the transfectants by up to 58%.	Gangliosides	140-151	UDP-glucose ceramide glucosyltransferase	Mus musculus	72-97
11971858-7	2002	These findings demonstrate that stable transfection of glucosylceramide synthase antisense reduces cellular glycosphingolipid levels and reduces tumorigenicity, providing further experimental support for an enhancing role of gangliosides in tumor formation.	Gangliosides	225-237	UDP-glucose ceramide glucosyltransferase	Mus musculus	55-80
12815229-5	2002	The molar ratio between GM3 and GD3 varied from 418 to 0.6 in the ganglioside mixtures, as determined by densitometric quantitative analysis after thin layer chromatographic separation.	Gangliosides	66-77	GRDX	Homo sapiens	32-35
11999340-3	2002	In T cells activated by crosslinking the GPI-linked protein Thy-1 or by crosslinking the ganglioside GM1, reggie-1/flotillin-2 co-localizes with the T cell receptor.	Gangliosides	89-100	flotillin 2	Homo sapiens	115-126
11861662-5	2002	The major serum ganglioside, N-glycolyl GalNAcbeta1-4[NeuNAcalpha2-3]Galbeta1-4Glc-Cer (N-glycolyl GM2), was increased in concentration by approximately 3-fold.	Gangliosides	16-27	cytochrome b5 domain containing 2	Mus musculus	99-102
11934394-1	2002	Addition of a small amount of ganglioside GM(1) to phosphatidylserine (PS) liposomes, a gradual increase of protein kinase C (PKC) activity was recorded up to about 2 mol% GM(1) where the maximal enzyme activity was obtained.	Gangliosides	30-41	proline rich transmembrane protein 2	Homo sapiens	108-124
11934394-1	2002	Addition of a small amount of ganglioside GM(1) to phosphatidylserine (PS) liposomes, a gradual increase of protein kinase C (PKC) activity was recorded up to about 2 mol% GM(1) where the maximal enzyme activity was obtained.	Gangliosides	30-41	proline rich transmembrane protein 2	Homo sapiens	126-129
11861662-8	2002	The spectrum of gangliosides present in the aortic tissues was more complex than that found in the lipoproteins, with the latter represented almost entirely by N-glycolyl GM2 and the former comprised of NeuNAcalpha2-3Galbeta1-4Glc-Cer (GM3), GM2, N-glycolyl GM2, GM1, GD3, and GD1a.	Gangliosides	16-28	granulocyte macrophage antigen 3	Mus musculus	236-239
11999980-6	2002	The generalized reduction of gangliosides and their modified distribution together with the central nervous system GD3 increment represent a new observation.	Gangliosides	29-41	GRDX	Homo sapiens	115-118
11861662-8	2002	The spectrum of gangliosides present in the aortic tissues was more complex than that found in the lipoproteins, with the latter represented almost entirely by N-glycolyl GM2 and the former comprised of NeuNAcalpha2-3Galbeta1-4Glc-Cer (GM3), GM2, N-glycolyl GM2, GM1, GD3, and GD1a.	Gangliosides	16-28	cytochrome b5 domain containing 2	Mus musculus	242-245
11861662-8	2002	The spectrum of gangliosides present in the aortic tissues was more complex than that found in the lipoproteins, with the latter represented almost entirely by N-glycolyl GM2 and the former comprised of NeuNAcalpha2-3Galbeta1-4Glc-Cer (GM3), GM2, N-glycolyl GM2, GM1, GD3, and GD1a.	Gangliosides	16-28	cytochrome b5 domain containing 2	Mus musculus	242-245
11861662-8	2002	The spectrum of gangliosides present in the aortic tissues was more complex than that found in the lipoproteins, with the latter represented almost entirely by N-glycolyl GM2 and the former comprised of NeuNAcalpha2-3Galbeta1-4Glc-Cer (GM3), GM2, N-glycolyl GM2, GM1, GD3, and GD1a.	Gangliosides	16-28	coenzyme Q10A	Mus musculus	263-266
11861662-9	2002	In conclusion, neutral GSL and ganglioside levels were increased in the serum and aortae of apoE-/- mice compared with controls, and this was associated with a preferential redistribution of GSL to the proatherogenic lipoprotein populations.	Gangliosides	31-42	apolipoprotein E	Mus musculus	92-96
11828255-8	2002	Transformation of UISO-CMN-1 cells into tumorigenic cells was accompanied by induction of ganglioside-2 expression without any significant changes in cellular ganglioside-3.	Gangliosides	90-101	cardiac modifier of nmd 1	Mus musculus	23-28
12235869-5	2002	Thin-layer chromatographic analysis of changes in the cell membrane ganglioside GM3 showed a marked increase in GM3 in the 4-HPR-TAM combination group.	Gangliosides	68-79	haptoglobin-related protein	Homo sapiens	125-128
12102145-1	2002	We have found that an increase in the ganglioside GM3 is a prerequisite for the induction of terminal differentiation, cuhninating in death by apoptosis, of human colonic carcinoma cells in vitro.	Gangliosides	38-49	granulocyte macrophage antigen 3	Mus musculus	50-53
11734218-7	2001	Furthermore, by using fluorescein-coupled cholera toxin B subunit, which specifically binds to the raft component ganglioside GM1, we identified caveolin- and Trp-independent lipid rafts residing in the plasma membrane of mature sperm.	Gangliosides	114-125	coenzyme Q10A	Mus musculus	126-129
11859933-0	2001	Gangliosides inhibit the release of interleukin-1beta in amyloid beta-protein-treated human monocytic cells.	Gangliosides	0-12	interleukin 1 beta	Homo sapiens	36-53
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p < 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	163-175	interleukin 1 beta	Homo sapiens	15-23
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p < 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	163-175	amyloid beta precursor protein	Homo sapiens	29-35
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p < 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	163-175	interleukin 1 beta	Homo sapiens	242-250
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p < 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	193-205	interleukin 1 beta	Homo sapiens	15-23
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p < 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	193-205	amyloid beta precursor protein	Homo sapiens	29-35
11859933-7	2001	The release of IL-1beta from A beta 1-42-activated cells was significantly inhibited (33-48% of activated cells; p < 0.05 for the control value) by addition of gangliosides, suggesting that gangliosides inhibit the continuous cycle of the IL-1beta production in THP-1 cells.	Gangliosides	193-205	interleukin 1 beta	Homo sapiens	242-250
11577096-6	2001	The ganglioside-induced inhibition of Akt phosphorylation was GT1b-specific and was not observed when cells were treated with other keratinocyte gangliosides, including GD3.	Gangliosides	4-15	AKT serine/threonine kinase 1	Homo sapiens	38-41
11577096-6	2001	The ganglioside-induced inhibition of Akt phosphorylation was GT1b-specific and was not observed when cells were treated with other keratinocyte gangliosides, including GD3.	Gangliosides	4-15	GRDX	Homo sapiens	169-172
12150006-3	2002	We found reactivity against gangliosides GD3, GD1b, and GT1b in one of them and against GD1a in the other, even though both had nearly identical clinical pictures.	Gangliosides	28-40	GRDX	Homo sapiens	41-44
11705889-1	2001	Escherichia coli type IIa heat-labile enterotoxin (LTIIa) binds in vitro with highest affinity to ganglioside GD1b.	Gangliosides	98-109	colicin Ia immunity protein	Escherichia coli	22-25
11903928-1	2001	This work describes the in vivo expression and distribution of glioma-associated gangliosides (GD3, GM2, 3"-isoLM1) in a novel human brain tumour nude rat xenograft model.	Gangliosides	81-93	GRDX	Homo sapiens	95-98
11903928-6	2001	Ganglioside GD3 was expressed in the tumour parenchyma while ganglioside 3"-isoLM1 was more abundantly expressed in the periphery of the tumour associated with areas of tumour cell invasion.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
11903928-9	2001	This work supports the concept of different biological roles for individual gangliosides and indicates that antibodies or ligands directed against GD3 and 3"-isoLM1 might be complementary when applied in the treatment of human glioblastomas.	Gangliosides	76-88	GRDX	Homo sapiens	147-150
11781858-5	2001	RESULTS: Ganglioside GfD1b/GD1b and GD3 were the most abundant gangliosides in all examined tissues.	Gangliosides	63-75	GRDX	Homo sapiens	36-39
11574545-5	2001	PAR-4 expression and apoptosis were restored by preincubation of ST2-transfected cells with N-butyl deoxinojirimycin (NB-DNJ) or PD98059, two inhibitors of ganglioside biosynthesis or p42/44 mitogen-activated protein (MAPK) kinase, respectively.	Gangliosides	156-167	PRKC, apoptosis, WT1, regulator	Mus musculus	0-5
11577096-0	2001	Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis.	Gangliosides	83-94	integrin linked kinase	Homo sapiens	14-36
11577096-0	2001	Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis.	Gangliosides	83-94	protein tyrosine kinase 2 beta	Homo sapiens	37-53
11577096-0	2001	Inhibition of integrin-linked kinase/protein kinase B/Akt signaling: mechanism for ganglioside-induced apoptosis.	Gangliosides	83-94	AKT serine/threonine kinase 1	Homo sapiens	54-57
11577096-1	2001	Ganglioside GT1b inhibits keratinocyte attachment to and migration on a fibronectin matrix by binding to alpha(5)beta(1) and preventing alpha(5)beta(1) interaction with fibronectin.	Gangliosides	0-11	fibronectin 1	Homo sapiens	72-83
11577096-1	2001	Ganglioside GT1b inhibits keratinocyte attachment to and migration on a fibronectin matrix by binding to alpha(5)beta(1) and preventing alpha(5)beta(1) interaction with fibronectin.	Gangliosides	0-11	fibronectin 1	Homo sapiens	169-180
11734218-7	2001	Furthermore, by using fluorescein-coupled cholera toxin B subunit, which specifically binds to the raft component ganglioside GM1, we identified caveolin- and Trp-independent lipid rafts residing in the plasma membrane of mature sperm.	Gangliosides	114-125	caveolin 1, caveolae protein	Mus musculus	145-153
11694322-3	2001	One patient showed serum IgG immunoreactivity against gangliosides GD3 and GQ1b.	Gangliosides	54-66	GRDX	Homo sapiens	67-70
11701079-1	2001	BACKGROUND: Ganglioside G(M1) is a membrane glycolipid typical of nerve cell membranes, where it partakes in neurotransmitter release and is catabolized by the lysosomal beta-galactosidase (GM1ase) (EC 3.2.1.23).	Gangliosides	12-23	galactosidase beta 1	Homo sapiens	170-188
11745410-0	2001	Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met.	Gangliosides	0-11	hepatocyte growth factor	Homo sapiens	26-29
11745410-0	2001	Ganglioside GD1a inhibits HGF-induced motility and scattering of cancer cells through suppression of tyrosine phosphorylation of c-Met.	Gangliosides	0-11	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	129-134
11557751-5	2001	In addition, cholesterol and membrane-associated sialic acid residue depletion or inhibition of cholesterol and ganglioside synthesis protected PC12 cells from Abeta-induced toxicity.	Gangliosides	112-123	amyloid beta precursor protein	Rattus norvegicus	160-165
11672434-1	2001	We have previously reported that a heat-stable activator for ganglioside metabolism, G(M2) activator, potently stimulates ADP-ribosylation factor (ARF)-dependent phospholipase D (PLD) activity (presumably PLD1) in an in vitro system [Nakamura, Akisue, Jinnai, Hitomi, Sarkar, Miwa, Okada, Yoshida, Kuroda, Kikkawa and Nishizuka (1998) Proc.	Gangliosides	61-72	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	162-177
11672434-1	2001	We have previously reported that a heat-stable activator for ganglioside metabolism, G(M2) activator, potently stimulates ADP-ribosylation factor (ARF)-dependent phospholipase D (PLD) activity (presumably PLD1) in an in vitro system [Nakamura, Akisue, Jinnai, Hitomi, Sarkar, Miwa, Okada, Yoshida, Kuroda, Kikkawa and Nishizuka (1998) Proc.	Gangliosides	61-72	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	179-182
11672434-1	2001	We have previously reported that a heat-stable activator for ganglioside metabolism, G(M2) activator, potently stimulates ADP-ribosylation factor (ARF)-dependent phospholipase D (PLD) activity (presumably PLD1) in an in vitro system [Nakamura, Akisue, Jinnai, Hitomi, Sarkar, Miwa, Okada, Yoshida, Kuroda, Kikkawa and Nishizuka (1998) Proc.	Gangliosides	61-72	phospholipase D1	Homo sapiens	205-209
11578853-0	2001	Sites and temporal changes of gangliosides GM1/GM2 storage in the Niemann-Pick disease type C mouse brain.	Gangliosides	30-42	coenzyme Q10A	Mus musculus	43-46
11715037-7	2001	The Golgi apparatus constitutes a privileged site for the generation of the pro-apoptotic mediator ganglioside GD3, facilitates local caspase-2 activation and might serve as a storage organelle for latent death receptors.	Gangliosides	99-110	GRDX	Homo sapiens	111-114
11715037-7	2001	The Golgi apparatus constitutes a privileged site for the generation of the pro-apoptotic mediator ganglioside GD3, facilitates local caspase-2 activation and might serve as a storage organelle for latent death receptors.	Gangliosides	99-110	caspase 2	Homo sapiens	134-143
11507070-1	2001	We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective immunity against murine melanoma induced by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to murine melanoma peptide epitopes gp100(25-35) and TRP-2(181-188).	Gangliosides	48-59	interleukin 2	Mus musculus	107-110
11591370-0	2001	Evidence for cell surface association between CXCR4 and ganglioside GM3 after gp120 binding in SupT1 lymphoblastoid cells.	Gangliosides	56-67	C-X-C motif chemokine receptor 4	Homo sapiens	46-51
11553690-0	2001	Immunoseparation of sphingolipid-enriched membrane domains enriched in Src family protein tyrosine kinases and in the neuronal adhesion molecule TAG-1 by anti-GD3 ganglioside monoclonal antibody.	Gangliosides	163-174	contactin 2	Rattus norvegicus	145-150
11579119-1	2001	PURPOSE: KM871 is a chimeric monoclonal antibody against the ganglioside antigen GD3, which is highly expressed on melanoma cells.	Gangliosides	61-72	GRDX	Homo sapiens	81-84
11451961-1	2001	The cell density-dependent growth inhibition of human SK-N-MC neuroblastoma cells is initiated by increased ganglioside sialidase activity leading to elevated cell surface presentation of ganglioside GM1, a ligand of galectin-1.	Gangliosides	108-119	hedgehog acyltransferase	Homo sapiens	54-58
11451961-1	2001	The cell density-dependent growth inhibition of human SK-N-MC neuroblastoma cells is initiated by increased ganglioside sialidase activity leading to elevated cell surface presentation of ganglioside GM1, a ligand of galectin-1.	Gangliosides	108-119	galectin 1	Homo sapiens	217-227
11587568-1	2001	R24 is a mouse IgG3 monoclonal antibody (mab) that reacts with the ganglioside GD3 expressed by cells of neuroectodermal origin.	Gangliosides	67-78	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	15-19
11587568-1	2001	R24 is a mouse IgG3 monoclonal antibody (mab) that reacts with the ganglioside GD3 expressed by cells of neuroectodermal origin.	Gangliosides	67-78	GRDX	Homo sapiens	79-82
11522302-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	Gangliosides	13-25	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
11507070-1	2001	We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective immunity against murine melanoma induced by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to murine melanoma peptide epitopes gp100(25-35) and TRP-2(181-188).	Gangliosides	48-59	premelanosome protein	Mus musculus	307-312
11507070-1	2001	We demonstrate that a mouse-human chimeric anti-ganglioside GD2-interleukin (IL)-2 fusion protein (ch14.18-IL2) substantially amplifies tumor-protective immunity against murine melanoma induced by an autologous oral DNA vaccine containing the murine ubiquitin gene fused to murine melanoma peptide epitopes gp100(25-35) and TRP-2(181-188).	Gangliosides	48-59	tRNA proline 2	Mus musculus	324-329
11447130-1	2001	Gangliosides are able to bind to the epidermal growth factor receptor and inhibit its activation, but the mechanism of this inhibition is unknown.	Gangliosides	0-12	Epidermal growth factor receptor	Drosophila melanogaster	37-69
11513089-1	2001	Bovine lactoferrin was enriched in various whey samples by affinity chromatography using immobilized gangliosides.	Gangliosides	101-113	lactotransferrin	Bos taurus	7-18
11513089-8	2001	These results show that immobilized gangliosides can be used to enrich the lactoferrin content of whey.	Gangliosides	36-48	lactotransferrin	Bos taurus	75-86
11522397-5	2001	Here we review recent studies that reflect on the role of gangliosides, sialylated glycosphingolipids, as functional MAG ligands.	Gangliosides	58-70	myelin-associated glycoprotein	Mus musculus	117-120
11522397-6	2001	MAG binds to gangliosides with the terminal sequence "NeuAc alpha 3Gal beta 3GalNAc" which is found on the major nerve gangliosides GD1a and GT1b.	Gangliosides	13-25	myelin-associated glycoprotein	Mus musculus	0-3
11522397-11	2001	Cross-linking nerve cell surface gangliosides can mimic MAG-mediated inhibition of nerve regeneration.	Gangliosides	33-45	myelin-associated glycoprotein	Mus musculus	56-59
11522397-12	2001	Taken together these observations implicate gangliosides as functional MAG ligands.	Gangliosides	44-56	myelin-associated glycoprotein	Mus musculus	71-74
11595162-1	2001	GM3 synthase, which transfers CMP-NeuAc with an alpha2,3-linkage to a galactose residue of lactosylceramide, plays a key role in the biosynthesis of all complex gangliosides.	Gangliosides	161-173	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
11604106-4	2001	In addition, amino acid sequence analysis of the H-CDRs of this MAb revealed the presence of three arginines, two of which are present in the H-CDR3, that could be involved in the interaction of P3 MAb with its electronegative epitope on gangliosides.	Gangliosides	238-250	CDR3	Homo sapiens	142-148
11604106-8	2001	Therefore, complementary electrostatic interactions involving H-CDR3 from both Ab1 and Ab2, might provide a clue to understand the molecular basis for the generation of gamma-type anti-idiotype antibodies to V regions recognizing glycolylated ganglioside antigens.	Gangliosides	243-254	CDR3	Homo sapiens	62-68
11511306-0	2001	Gangliosides GD1b, GT1b, and GQ1b suppress the growth of human melanoma by inhibiting interleukin-8 production: the inhibition of adenylate cyclase.	Gangliosides	0-12	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
11447130-7	2001	These studies suggest that ganglioside affects epidermal growth factor receptor activity through a direct interaction that requires receptor glycosylation, and contribute to our understanding of the role of gangliosides in cell membrane function.	Gangliosides	27-38	Epidermal growth factor receptor	Drosophila melanogaster	47-79
11447130-7	2001	These studies suggest that ganglioside affects epidermal growth factor receptor activity through a direct interaction that requires receptor glycosylation, and contribute to our understanding of the role of gangliosides in cell membrane function.	Gangliosides	207-219	Epidermal growth factor receptor	Drosophila melanogaster	47-79
11279053-0	2001	Myelin-associated glycoprotein interacts with ganglioside GT1b.	Gangliosides	46-57	myelin associated glycoprotein	Homo sapiens	0-30
11517490-6	2001	It is suggested that unknown anti-ganglioside antibody may play an important role in cases of PCB.	Gangliosides	34-45	pyruvate carboxylase	Homo sapiens	94-97
11279053-3	2001	MAG has a sialic acid binding site in its N-terminal domain and binds to specific sialylated glycans and gangliosides present on the surface of neurons, but the significance of these interactions in the effect of MAG on neurite outgrowth is unclear.	Gangliosides	105-117	myelin associated glycoprotein	Homo sapiens	0-3
11279053-7	2001	We then go on to investigate gangliosides GT1b and GD1a as candidate MAG receptors.	Gangliosides	29-41	myelin associated glycoprotein	Homo sapiens	69-72
11279053-8	2001	We show that MAG specifically binds both gangliosides and that both are expressed on the surface of MAG-responsive neurons.	Gangliosides	41-53	myelin associated glycoprotein	Homo sapiens	13-16
11438174-0	2001	Brain-derived gangliosides suppress the chronic relapsing-remitting experimental autoimmune encephalomyelitis in NOD mice induced with myelin oligodendrocyte glycoprotein peptide.	Gangliosides	14-26	myelin oligodendrocyte glycoprotein	Mus musculus	135-170
11516650-8	2001	Second, in the presence of Nef, viral envelopes contain more ganglioside (GM1), which is a major component of lipid rafts.	Gangliosides	61-72	S100 calcium binding protein B	Homo sapiens	27-30
11389909-3	2001	Out of other gangliosides tested, 2-->6 sialylparagloboside, GD3, GD2, and GT1b, but not other lacto- or ganglio-series gangliosides, showed clear binding to siglec7.	Gangliosides	13-25	sialic acid binding Ig like lectin 7	Homo sapiens	161-168
11438174-1	2001	Chronic relapsing-remitting experimental autoimmune encephalomyelitis (CREAE) induced with myelin oligodendrocyte glycoprotein peptides 35-55 (MOG(35-55)) in NOD mice was successfully treated with brain-derived gangliosides (GA).	Gangliosides	211-223	myelin oligodendrocyte glycoprotein	Mus musculus	91-126
11438174-3	2001	Spleen cells from the GA-treated mice displayed markedly inhibited levels of MOG(35-55) specific proliferation and interferon-gamma production.	Gangliosides	22-24	myelin oligodendrocyte glycoprotein	Mus musculus	77-80
11438174-3	2001	Spleen cells from the GA-treated mice displayed markedly inhibited levels of MOG(35-55) specific proliferation and interferon-gamma production.	Gangliosides	22-24	interferon gamma	Mus musculus	115-131
11519719-4	2001	The activity for synthesis of gangliosides was evaluated by determining the incorporation of N-acetyl [3H]neuraminc acid ([3H]NeuAc) into the endogenous gangliosides of Golgi membranes and by determining the activity of Sial-T2 (GD3 synthase) and GalNAc-T (GM2 synthase), the two enzymes acting on sialyllactosylceramide (GM3) at the branching point of synthesis of a- and b-ganglioside pathway.	Gangliosides	30-42	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	229-241
11519719-4	2001	The activity for synthesis of gangliosides was evaluated by determining the incorporation of N-acetyl [3H]neuraminc acid ([3H]NeuAc) into the endogenous gangliosides of Golgi membranes and by determining the activity of Sial-T2 (GD3 synthase) and GalNAc-T (GM2 synthase), the two enzymes acting on sialyllactosylceramide (GM3) at the branching point of synthesis of a- and b-ganglioside pathway.	Gangliosides	30-42	beta-1,4-N-acetyl-galactosaminyl transferase 1	Rattus norvegicus	247-255
11519719-4	2001	The activity for synthesis of gangliosides was evaluated by determining the incorporation of N-acetyl [3H]neuraminc acid ([3H]NeuAc) into the endogenous gangliosides of Golgi membranes and by determining the activity of Sial-T2 (GD3 synthase) and GalNAc-T (GM2 synthase), the two enzymes acting on sialyllactosylceramide (GM3) at the branching point of synthesis of a- and b-ganglioside pathway.	Gangliosides	30-41	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	229-241
11519719-4	2001	The activity for synthesis of gangliosides was evaluated by determining the incorporation of N-acetyl [3H]neuraminc acid ([3H]NeuAc) into the endogenous gangliosides of Golgi membranes and by determining the activity of Sial-T2 (GD3 synthase) and GalNAc-T (GM2 synthase), the two enzymes acting on sialyllactosylceramide (GM3) at the branching point of synthesis of a- and b-ganglioside pathway.	Gangliosides	30-41	beta-1,4-N-acetyl-galactosaminyl transferase 1	Rattus norvegicus	247-255
11327710-1	2001	We have developed a solid matrix immunoassay to determine the binding of interleukin-2 (IL-2) to specific gangliosides.	Gangliosides	106-118	interleukin 2	Homo sapiens	73-86
11468510-8	2001	The importance of ganglioside structure in the tumour-protective effect of GM3/VSSP vaccine was confirmed using GM3 containing N-glycolylneuraminic acid, a ganglioside absent in melanoma cells.	Gangliosides	156-167	granulocyte macrophage antigen 3	Mus musculus	75-78
11327710-4	2001	This assay enables distinguishing the nature of the sugar moiety of the ganglioside recognized by IL-2 and establishes the dosimetry of the ganglioside-IL-2 interaction.	Gangliosides	72-83	interleukin 2	Homo sapiens	98-102
11468510-5	2001	Immunization with four doses of GM3/VSSP vaccine (120 microg of ganglioside) plus Freund"s adjuvant or Montanide ISA 51 significantly increased the overall survival of mice inoculated in the subcutis with 103 B16-F1 cells, whereas the GM3/VLDL immunogen was ineffective.	Gangliosides	64-75	granulocyte macrophage antigen 3	Mus musculus	32-35
11468510-8	2001	The importance of ganglioside structure in the tumour-protective effect of GM3/VSSP vaccine was confirmed using GM3 containing N-glycolylneuraminic acid, a ganglioside absent in melanoma cells.	Gangliosides	18-29	granulocyte macrophage antigen 3	Mus musculus	75-78
11327710-4	2001	This assay enables distinguishing the nature of the sugar moiety of the ganglioside recognized by IL-2 and establishes the dosimetry of the ganglioside-IL-2 interaction.	Gangliosides	72-83	interleukin 2	Homo sapiens	152-156
11327710-1	2001	We have developed a solid matrix immunoassay to determine the binding of interleukin-2 (IL-2) to specific gangliosides.	Gangliosides	106-118	interleukin 2	Homo sapiens	88-92
11327710-4	2001	This assay enables distinguishing the nature of the sugar moiety of the ganglioside recognized by IL-2 and establishes the dosimetry of the ganglioside-IL-2 interaction.	Gangliosides	140-151	interleukin 2	Homo sapiens	152-156
11327710-2	2001	The assay establishes that recombinant human IL-2 binds to ganglioside GD(1b) but not to any other gangliosides (GM(1), GM(2), GM(3), GD(1a), GD(2), GD(3), and GT(1b)).	Gangliosides	99-111	interleukin 2	Homo sapiens	45-49
11426707-0	2001	Rapid fractionation of bovine transferrin using immobilized gangliosides.	Gangliosides	60-72	serotransferrin	Bos taurus	30-41
11426707-1	2001	Bovine transferrin (BTF) was fractionated from bovine whey using ganglioside affinity chromatography.	Gangliosides	65-76	serotransferrin	Bos taurus	7-18
11275367-1	2001	Ganglioside GM2 is one of the major gangliosides expressed on the cell surface of human tumors including lung cancer.	Gangliosides	0-11	cytochrome b5 domain containing 2	Mus musculus	12-15
11275367-1	2001	Ganglioside GM2 is one of the major gangliosides expressed on the cell surface of human tumors including lung cancer.	Gangliosides	36-48	cytochrome b5 domain containing 2	Mus musculus	12-15
11284735-0	2001	Modulation of epidermal growth factor receptor phosphorylation by endogenously expressed gangliosides.	Gangliosides	89-101	epidermal growth factor receptor	Cricetulus griseus	14-46
11284735-1	2001	The effect of changing the ganglioside composition of Chinese hamster ovary K1 cells on the function of the epidermal growth factor receptor (EGFr) was examined by studying the signalling pathway generated after the binding of epidermal growth factor (EGF) both in cells depleted of glycosphingolipids by inhibiting glucosylceramide synthase activity and in cell lines expressing different gangliosides as the result of stable transfection of appropriate ganglioside glycosyltransferases.	Gangliosides	27-38	epidermal growth factor receptor	Cricetulus griseus	108-140
11284735-1	2001	The effect of changing the ganglioside composition of Chinese hamster ovary K1 cells on the function of the epidermal growth factor receptor (EGFr) was examined by studying the signalling pathway generated after the binding of epidermal growth factor (EGF) both in cells depleted of glycosphingolipids by inhibiting glucosylceramide synthase activity and in cell lines expressing different gangliosides as the result of stable transfection of appropriate ganglioside glycosyltransferases.	Gangliosides	27-38	epidermal growth factor receptor	Cricetulus griseus	142-146
11284735-1	2001	The effect of changing the ganglioside composition of Chinese hamster ovary K1 cells on the function of the epidermal growth factor receptor (EGFr) was examined by studying the signalling pathway generated after the binding of epidermal growth factor (EGF) both in cells depleted of glycosphingolipids by inhibiting glucosylceramide synthase activity and in cell lines expressing different gangliosides as the result of stable transfection of appropriate ganglioside glycosyltransferases.	Gangliosides	390-402	epidermal growth factor receptor	Cricetulus griseus	108-140
11284735-1	2001	The effect of changing the ganglioside composition of Chinese hamster ovary K1 cells on the function of the epidermal growth factor receptor (EGFr) was examined by studying the signalling pathway generated after the binding of epidermal growth factor (EGF) both in cells depleted of glycosphingolipids by inhibiting glucosylceramide synthase activity and in cell lines expressing different gangliosides as the result of stable transfection of appropriate ganglioside glycosyltransferases.	Gangliosides	390-402	epidermal growth factor receptor	Cricetulus griseus	142-146
11352656-0	2001	Ganglioside GD1a enhances VEGF-induced endothelial cell proliferation and migration.	Gangliosides	0-11	vascular endothelial growth factor A	Homo sapiens	26-30
11368158-5	2001	A beta 1-40 bound to a number of gangliosides with the following order of binding strength: GQ1b alpha > GT1a alpha > GQ1b > GT1b > GD3 > GD1a = GD1b > LM1 > GM1 > GM2 = GM3 > GM4.	Gangliosides	33-45	GRDX	Homo sapiens	132-135
11368158-6	2001	Neutral glycosphingolipids had a lower affinity for A beta 1-40 than gangliosides with the following order of binding strength: Gb4 > asialo-GM1 (GA1) > Gb3 > asialo-GM2 (GA2) = LacCer.	Gangliosides	69-81	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	153-156
11352656-4	2001	Here we assessed the influence of a highly purified ganglioside, G(D1a), on responses of normal human umbilical vein endothelial cells (HUVEC) to VEGF.	Gangliosides	52-63	vascular endothelial growth factor A	Homo sapiens	146-150
11352656-7	2001	These findings suggest that gangliosides shed by tumor cells can promote tumor angiogenesis by enhancing the VEGF response of endothelial cells in the tumor microenvironment.	Gangliosides	28-40	vascular endothelial growth factor A	Homo sapiens	109-113
11298736-7	2001	R114Q demonstrated a substrate specificity shift in the same direction as E51D, whereas R114A enhanced the preference for gangliosides GD3 and GD1a that are effectively hydrolyzed by the wild-type.	Gangliosides	122-134	GRDX	Homo sapiens	135-138
11310672-7	2001	These three ganglioside molecular species showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell, in the presence of NGF (nerve growth factor).	Gangliosides	12-23	nerve growth factor	Rattus norvegicus	145-148
11310672-7	2001	These three ganglioside molecular species showed neuritogenic activity toward the rat pheochromocytoma cell line, PC-12 cell, in the presence of NGF (nerve growth factor).	Gangliosides	12-23	nerve growth factor	Rattus norvegicus	150-169
11278374-2	2001	Since most previous in vitro investigations used micellar ganglioside GM2 as substrate, we studied the degradation of membrane-bound ganglioside GM2 by water-soluble beta-hexosaminidase A in the presence of the GM2 activator protein in a detergent-free, liposomal assay system.	Gangliosides	133-144	O-GlcNAcase	Homo sapiens	166-185
11602807-4	2001	Gangliosides recognized by anti-VIM-2 antibodies were detected mainly in the acid fractions of azurophil and specific granules.	Gangliosides	0-12	vimentin 2, pseudogene	Homo sapiens	32-37
11292670-0	2001	Ganglioside GD3 enhances apoptosis by suppressing the nuclear factor-kappa B-dependent survival pathway.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
11276053-6	2001	Based on different in vitro approaches, we found that the substrate-bound glycoprotein selectively inhibits the fibronectin-dependent: (1) neurite outgrowth from dorsal root ganglion neurons (strongly expressing alpha5beta1 integrin and the disialoganglioside GD3) by a ganglioside-sensitive signaling mechanism; and (2) migration of primary myoblasts and other non-neuronal cells in a ganglioside-independent manner.	Gangliosides	248-259	fibronectin 1	Homo sapiens	112-123
11276053-6	2001	Based on different in vitro approaches, we found that the substrate-bound glycoprotein selectively inhibits the fibronectin-dependent: (1) neurite outgrowth from dorsal root ganglion neurons (strongly expressing alpha5beta1 integrin and the disialoganglioside GD3) by a ganglioside-sensitive signaling mechanism; and (2) migration of primary myoblasts and other non-neuronal cells in a ganglioside-independent manner.	Gangliosides	270-281	fibronectin 1	Homo sapiens	112-123
11133999-4	2001	GD3S-/- mice, even with an absence of b-series gangliosides, appear to undergo normal development and have a normal life span.	Gangliosides	47-59	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	0-4
11133999-6	2001	These double mutant mice expressed GM3 as their major ganglioside.	Gangliosides	54-65	granulocyte macrophage antigen 3	Mus musculus	35-38
11259118-1	2001	The simple ganglioside GM3 inhibits proliferation and induces apoptosis in proliferating immature rodent CNS cells.	Gangliosides	11-22	granulocyte macrophage antigen 3	Mus musculus	23-26
11358882-1	2001	Using the cholera toxin B subunit (CTB) that specifically binds to ganglioside GM1a on the plasma membrane, we investigated intracellular signaling mediated by endogenous GM1a involved in neuronal differentiation of PC12 cells.	Gangliosides	67-78	phosphate cytidylyltransferase 1B, choline	Rattus norvegicus	35-38
11358882-10	2001	Considered together, we concluded that tyrosine phosphorylation induced with CTB was responsible for neuron-like differentiation of PC12 cells and that the MEK-ERK cascade is part of the biological signals mediated by endogenous ganglioside GM1a on PC12 cells.	Gangliosides	229-240	Eph receptor B1	Rattus norvegicus	160-163
11282993-0	2001	Evidence for a role of ganglioside GM1 in antigen presentation: binding enhances presentation of Escherichia coli enterotoxin B subunit (EtxB) to CD4(+) T cells.	Gangliosides	23-34	CD4 molecule	Homo sapiens	146-149
11478381-8	2001	The plasmalogen-selective phospholipase A2 differs from other intracellular phospholipases A2 in molecular mass, kinetic properties, substrate specificity, and response to glycosaminoglycans, gangliosides, and sialoglycoproteins.	Gangliosides	192-204	phospholipase A2, group IB, pancreas	Mus musculus	26-42
11495348-1	2001	We previously reported that ciliary neurotrophic factor (CNTF) increased the serum-free cell survival of immortalized motor neuron-like cells (NSC-34), and addition of the exogenous ganglioside GalNAc beta4(Neu5Ac alpha3)Gal beta4GlcCer (GM2) facilitated cell survival together with CNTF.	Gangliosides	182-193	cytochrome b5 domain containing 2	Mus musculus	238-241
11495348-1	2001	We previously reported that ciliary neurotrophic factor (CNTF) increased the serum-free cell survival of immortalized motor neuron-like cells (NSC-34), and addition of the exogenous ganglioside GalNAc beta4(Neu5Ac alpha3)Gal beta4GlcCer (GM2) facilitated cell survival together with CNTF.	Gangliosides	182-193	ciliary neurotrophic factor	Mus musculus	283-287
11118433-1	2001	Gangliosides GT1b and GD3, components of keratinocyte membranes, inhibit keratinocyte adhesion to fibronectin.	Gangliosides	0-12	fibronectin 1	Homo sapiens	98-109
11118433-4	2001	Co-immunoprecipitation of GT1b and alpha(5)beta(1) from SCC12 cells and direct binding of GT1b and GD3 to affinity-purified alpha(5)beta(1) from SCC12 cells and insect recombinant alpha(5)beta(1), particularly the alpha(5) subunit, further suggest interaction between ganglioside and alpha(5)beta(1).	Gangliosides	268-279	GRDX	Homo sapiens	99-102
11118433-8	2001	These data provide evidence that highly sialylated gangliosides regulate alpha(5)beta(1)-mediated adhesion of epithelial cells to fibronectin through carbohydrate-carbohydrate interactions between GT1b and the alpha(5) subunit of alpha(5)beta(1) integrin.	Gangliosides	51-63	fibronectin 1	Homo sapiens	130-141
11270812-8	2001	The cytosolic sialidase is capable of desialylating a wide spectrum of different types of gangliosides using a thin-layer chromatography overlay kinetic assay without detergents.	Gangliosides	90-102	sialidase-2	Cricetulus griseus	4-23
11413682-4	2001	Four gangliosides were found and designated as GM3, GD3, GX1 and GX2, respectively.	Gangliosides	5-17	GRDX	Homo sapiens	52-55
11413682-6	2001	GD3 and GM3 were the major gangliosides in human milk (accounted for 50%-65%).	Gangliosides	27-39	GRDX	Homo sapiens	0-3
11370834-0	2001	Suppression of Ehrlich subcutaneous solid tumor growth by immunization with ganglioside GT1b of its origin, its IgM antibody or anti-idiotype antibody.	Gangliosides	76-87	retinoic acid induced 1	Mus musculus	88-91
11222633-9	2001	Distinct subpopulations of ST3GalV imply that ganglioside synthesis can occur outside of the Golgi or, alternatively, that a portion of the total ST3GalV pool subserves a nonenzymatic function.	Gangliosides	46-57	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	27-34
11160731-4	2001	The neuraminidase-sensitive and neuraminidase-insensitive rotavirus strains showed distinct ganglioside binding specificities.	Gangliosides	92-103	neuraminidase 1	Bos taurus	4-17
11160731-4	2001	The neuraminidase-sensitive and neuraminidase-insensitive rotavirus strains showed distinct ganglioside binding specificities.	Gangliosides	92-103	neuraminidase 1	Bos taurus	32-45
11160731-8	2001	Thus, neuraminidase-sensitive strains bind to external sialic acid residues in gangliosides, while neuraminidase-insensitive strains recognize gangliosides with internal sialic acids, which are resistant to neuraminidase treatment.	Gangliosides	79-91	neuraminidase 1	Bos taurus	6-19
11160731-8	2001	Thus, neuraminidase-sensitive strains bind to external sialic acid residues in gangliosides, while neuraminidase-insensitive strains recognize gangliosides with internal sialic acids, which are resistant to neuraminidase treatment.	Gangliosides	143-155	neuraminidase 1	Bos taurus	99-112
11160731-8	2001	Thus, neuraminidase-sensitive strains bind to external sialic acid residues in gangliosides, while neuraminidase-insensitive strains recognize gangliosides with internal sialic acids, which are resistant to neuraminidase treatment.	Gangliosides	143-155	neuraminidase 1	Bos taurus	99-112
11270813-11	2001	The increasing evidence on colocalization of gangliosides and sialidase in the cytosol strongly suggests the involvement of the cytosolic sialidase in ganglioside metabolism on intracellular level by yet unknown mechanisms.	Gangliosides	45-57	sialidase-2	Cricetulus griseus	128-147
11270813-11	2001	The increasing evidence on colocalization of gangliosides and sialidase in the cytosol strongly suggests the involvement of the cytosolic sialidase in ganglioside metabolism on intracellular level by yet unknown mechanisms.	Gangliosides	45-56	sialidase-2	Cricetulus griseus	128-147
11180008-10	2001	The ability of interferon-gamma to induce the transcription repressor BCL-6 may also contribute to the overall immunologic events in skin, including suppression of the intermediates in the synthetic pathway leading to expression of the T cell costimulatory ganglioside CDw60.	Gangliosides	257-268	interferon gamma	Homo sapiens	15-31
11280042-7	2001	On the other hand, the cleaving with neuraminidase of more than 50% of the sialic residues bound to endogenous gangliosides in resistant M4Be cells significantly increases their sensitivity to AL.	Gangliosides	111-123	neuraminidase 1	Homo sapiens	37-50
11180008-10	2001	The ability of interferon-gamma to induce the transcription repressor BCL-6 may also contribute to the overall immunologic events in skin, including suppression of the intermediates in the synthetic pathway leading to expression of the T cell costimulatory ganglioside CDw60.	Gangliosides	257-268	BCL6 transcription repressor	Homo sapiens	70-75
11134519-7	2001	These findings suggest that neurons from GalNAc-T knockout mice are lacking a calcium regulatory mechanism that is modulated by one or more of the deleted gangliosides, and they support the hypothesis that maintenance of calcium homeostasis is one function of complex gangliosides during, and perhaps subsequent to, neuronal development.	Gangliosides	268-280	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	41-49
11170409-0	2001	Complex gangliosides as cell surface inhibitors for the ecto-NAD+ glycohydrolase of CD38.	Gangliosides	8-20	CD38 molecule	Homo sapiens	84-88
11170409-5	2001	In the present study, we examined the effect of exogenous gangliosides on the NADase activity of CD38 on the surface of retinoic acid-treated human leukemic HL60 cells and CD38-transfected THP-1 cells.	Gangliosides	58-70	CD38 molecule	Homo sapiens	97-101
11170409-11	2001	These results suggest a novel role of complex gangliosides for the first time as cell surface inhibitors of CD38 through specific and cis interaction between the oligosaccharide moiety and the extracellular domain.	Gangliosides	46-58	CD38 molecule	Homo sapiens	108-112
11217952-0	2001	Synthesis of novel ganglioside GM4 analogues containing N-deacetylated and lactamized sialic acid: probes for searching new ligand structures for human L-selectin.	Gangliosides	19-30	selectin L	Homo sapiens	152-162
11270179-11	2001	In milk, gangliosides, sialic acid-containing glycolipid, occur mainly as monosialoganglioside 3 (GM3) and disialoganglioside 3 (GD3).	Gangliosides	9-21	GRDX	Homo sapiens	129-132
11673640-0	2001	Dietary gangliosides positively modulate the percentages of Th1 and Th2 lymphocyte subsets in small intestine of mice at weaning.	Gangliosides	8-20	negative elongation factor complex member C/D, Th1l	Mus musculus	60-63
14533812-0	2001	Analysis of a murine anti-ganglioside GD2 monoclonal antibody expressing both IgG2a and IgG3 isotypes: monoclonality, apoptosis triggering, and activation of cellular cytotoxicity on human melanoma cells.	Gangliosides	26-37	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	88-92
11673640-0	2001	Dietary gangliosides positively modulate the percentages of Th1 and Th2 lymphocyte subsets in small intestine of mice at weaning.	Gangliosides	8-20	heart and neural crest derivatives expressed 2	Mus musculus	68-71
11673640-6	2001	In addition, mice fed with the ganglioside-supplemented diet showed a significantly higher number of Th1 and Th2 cytokine-secreting lymphocytes than Control mice in lamina propria and Peyer"s patches lymphocytes at the end of the experimental period (28 days).	Gangliosides	31-42	negative elongation factor complex member C/D, Th1l	Mus musculus	101-104
11673640-6	2001	In addition, mice fed with the ganglioside-supplemented diet showed a significantly higher number of Th1 and Th2 cytokine-secreting lymphocytes than Control mice in lamina propria and Peyer"s patches lymphocytes at the end of the experimental period (28 days).	Gangliosides	31-42	heart and neural crest derivatives expressed 2	Mus musculus	109-112
11168800-0	2001	Ganglioside modulates ligand binding to the epidermal growth factor receptor.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	44-76
11123278-4	2001	These gangliosides decreased PHA-induced IL-4 secretion by 50-53% and that of IL-5 by 53-63% compared with controls, respectively.	Gangliosides	6-18	interleukin 4	Homo sapiens	41-45
11123278-4	2001	These gangliosides decreased PHA-induced IL-4 secretion by 50-53% and that of IL-5 by 53-63% compared with controls, respectively.	Gangliosides	6-18	interleukin 5	Homo sapiens	78-82
11196188-7	2001	Treatment of NB cells with 10 microM DL-threo-1-phenyl-2-decanolylamine-3-morpholino-1-propanol HCl, an inhibitor of glucosylceramide synthase, markedly abrogated ganglioside synthesis and was accompanied by blockade of NB ability to inhibit dendropoiesis.	Gangliosides	163-174	UDP-glucose ceramide glucosyltransferase	Homo sapiens	117-142
11123278-0	2001	Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells.	Gangliosides	0-12	interleukin 2	Homo sapiens	42-46
11123278-0	2001	Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells.	Gangliosides	0-12	interferon gamma	Homo sapiens	51-60
11123278-0	2001	Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells.	Gangliosides	0-12	interleukin 4	Homo sapiens	85-89
11123278-0	2001	Gangliosides GD1b, GT1b, and GQ1b enhance IL-2 and IFN-gamma production and suppress IL-4 and IL-5 production in phytohemagglutinin-stimulated human T cells.	Gangliosides	0-12	interleukin 5	Homo sapiens	94-98
11168800-1	2001	Whereas previous investigations have shown that pharmacologic addition of gangliosides inhibits keratinocyte proliferation by downregulating epidermal growth factor receptor phosphorylation, the underlying biochemical basis and physiologic relevance are unknown.	Gangliosides	74-86	epidermal growth factor receptor	Homo sapiens	141-173
11123278-2	2001	We studied the in vitro effects of gangliosides on Th1 and Th2 cytokine production in PHA-stimulated human T cells.	Gangliosides	35-47	negative elongation factor complex member C/D	Homo sapiens	51-54
11123278-3	2001	Gangliosides GD1b, GT1b, and GQ1b (each 100 nM) enhanced PHA-induced IL-2 secretion of peripheral blood T cells approximately 4-fold and enhanced that of IFN-gamma 3- to 4-fold compared with controls.	Gangliosides	0-12	interleukin 2	Homo sapiens	69-73
11168800-2	2001	Using Scatchard and displacement plots, we have shown that supplemental purified gangliosides decrease the binding of (125)I-labeled epidermal growth factor to keratinocyte-derived SCC12 cells.	Gangliosides	81-93	epidermal growth factor	Homo sapiens	133-156
11123278-3	2001	Gangliosides GD1b, GT1b, and GQ1b (each 100 nM) enhanced PHA-induced IL-2 secretion of peripheral blood T cells approximately 4-fold and enhanced that of IFN-gamma 3- to 4-fold compared with controls.	Gangliosides	0-12	interferon gamma	Homo sapiens	154-163
11168800-3	2001	Conversely, SCC12 cells transfected with sialidase and thus depleted of gangliosides show increased ligand binding to the epidermal growth factor receptor, which is consistent with their increased proliferation in response to epidermal growth factor and transforming growth factor-alpha, and increased phosphorylation of the epidermal growth factor receptor, and downstream signal transduction pathway components.	Gangliosides	72-84	epidermal growth factor receptor	Homo sapiens	122-154
11168800-3	2001	Conversely, SCC12 cells transfected with sialidase and thus depleted of gangliosides show increased ligand binding to the epidermal growth factor receptor, which is consistent with their increased proliferation in response to epidermal growth factor and transforming growth factor-alpha, and increased phosphorylation of the epidermal growth factor receptor, and downstream signal transduction pathway components.	Gangliosides	72-84	epidermal growth factor	Homo sapiens	122-145
11168800-3	2001	Conversely, SCC12 cells transfected with sialidase and thus depleted of gangliosides show increased ligand binding to the epidermal growth factor receptor, which is consistent with their increased proliferation in response to epidermal growth factor and transforming growth factor-alpha, and increased phosphorylation of the epidermal growth factor receptor, and downstream signal transduction pathway components.	Gangliosides	72-84	epidermal growth factor receptor	Homo sapiens	325-357
11168800-6	2001	Manipulation of membrane ganglioside content may be a powerful new means to alter epidermal growth factor receptor-dependent cell proliferation.	Gangliosides	25-36	epidermal growth factor receptor	Homo sapiens	82-114
11202175-7	2001	These studies suggest that the homeostatic regulation of gangliosides and cholesterol in neurons is mediated by NPC1 and that perturbations in this mechanism cause a complex neuronal storage disorder.	Gangliosides	57-69	NPC intracellular cholesterol transporter 1	Homo sapiens	112-116
11180643-1	2001	A general approach for the detection and structural elucidation of brain ganglioside species GM1, GD1 and GT1 by nano-electrospray ionization quadrupole time-of-flight (nanoESI-QTOF) mass spectrometry (MS), using combined data from MS and MS/MS analysis of isolated native ganglioside fractions in negative ion mode and their permethylated counterparts in the positive ion mode is presented.	Gangliosides	273-284	beta-1,4-galactosyltransferase 1	Homo sapiens	106-109
11108941-9	2001	High levels of IL-10-secreting MNC correlated with serum anti-ganglioside IgM antibody levels, and with neurophysiological signs of axonal damage.	Gangliosides	62-73	interleukin 10	Homo sapiens	15-20
11108947-6	2001	All sera from the SAN patients had remarkably high IgM antibody titers to the b-series gangliosides GD3, GD2, GD1b, GT1b, GQ1b, GQ1b alpha, fucosyl-GD1b, and alpha galactosyl [alpha fucosyl] GD1b.	Gangliosides	87-99	GRDX	Homo sapiens	100-103
11085888-0	2000	A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice.	Gangliosides	30-42	cytochrome b5 domain containing 2	Mus musculus	62-65
11118051-0	2000	Suppression of ganglioside GD3 expression in a rat F-11 tumor cell line reduces tumor growth, angiogenesis, and vascular endothelial growth factor production.	Gangliosides	15-26	vascular endothelial growth factor A	Rattus norvegicus	112-146
11118051-2	2000	In our previous study (G. Zeng et al., Biochemistry, 38: 8762-8769, 1999), we established a subclone of the rat dorsal root ganglion-derived F-11 cells in which the expression of ganglioside GD3 was inhibited by stable transfection of the antisense vector against CMP-NeuAc: GM3 alpha2-8 sialyltransferase (GD3-synthase) gene.	Gangliosides	179-190	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	307-319
11207603-5	2000	Other lipids such as gangliosides are able to inhibit the LLO-induced mucin exocytosis, suggesting that the binding of the toxin occurs at a multiplicity of membrane-associated lipids acting as receptors.	Gangliosides	21-33	LOC100508689	Homo sapiens	70-75
11156217-1	2000	Immunization with GMK vaccine (G(M2) ganglioside conjugated to keyhole limpet hemocyanin mixed with QS-21 adjuvant) induces anti-G(M2) antibodies in close to 100% of patients.	Gangliosides	37-48	guanylate kinase 1	Homo sapiens	18-21
11085888-2	2000	We report that mice engineered to lack a key enzyme in complex ganglioside biosynthesis (GM2/GD2 synthase), and which express only the simple ganglioside molecular species GM3 and GD3, develop significant and progressive behavioral neuropathies, including deficits in reflexes, strength, coordination, and balance.	Gangliosides	63-74	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	89-105
11411041-0	2000	Suppression of Ehrlich ascites tumor growth by immunization with ganglioside GT1b of its origin, its IgM antibody or anti-idiotype of the anti-GT1b IgM.	Gangliosides	65-76	retinoic acid induced 1	Mus musculus	77-80
11090283-1	2000	GM2 activator protein (GM2-AP) belongs to a small group of non- enzymatic lysosomal proteins that act as cofactors in the sequential degradation of gangliosides.	Gangliosides	148-160	ganglioside GM2 activator	Homo sapiens	0-21
11090283-1	2000	GM2 activator protein (GM2-AP) belongs to a small group of non- enzymatic lysosomal proteins that act as cofactors in the sequential degradation of gangliosides.	Gangliosides	148-160	ganglioside GM2 activator	Homo sapiens	23-29
10942779-9	2000	The enzymatic hydrolysis of the ganglioside GM1 is catalyzed by beta-galactosidase, a water-soluble acid exohydrolase.	Gangliosides	32-43	galactosidase beta 1	Homo sapiens	64-82
11399321-1	2000	A mouse/human chimeric monoclonal antibody (MAb) KM966, specific for the cell-surface tumor antigen ganglioside GM2, was humanized by the complementarity determining regions (CDRs) grafting method.	Gangliosides	100-111	cytochrome b5 domain containing 2	Mus musculus	112-115
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	Gangliosides	115-126	galactosidase beta 1	Homo sapiens	250-268
10942779-11	2000	In this study we demonstrate that an activator protein is required for the enzymatic degradation of membrane-bound ganglioside GM1 and that both SAP-B and the GM2 activator protein significantly enhance the degradation of the ganglioside GM1 by acid beta-galactosidase in a liposomal, detergent-free assay system.	Gangliosides	226-237	galactosidase beta 1	Homo sapiens	250-268
10931839-9	2000	In contrast, the cell surface binding of anti-ganglioside monoclonal antibody AA4 induced only strong general tyrosine phosphorylation of Syk and minimal histamine release and weak phosphorylation of activation loop tyrosines.	Gangliosides	46-57	spleen associated tyrosine kinase	Homo sapiens	138-141
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	Gangliosides	21-32	matrix metallopeptidase 11	Mus musculus	0-4
11093135-7	2000	Finally, reconstitution of TCR-negative Jurkat T cells with a CD8-CD3zeta chain chimera demonstrated that the cytoplasmic region of the CD3zeta chain was sufficient to couple ganglioside-mediated TTx binding to T cell activation.	Gangliosides	175-186	CD8a molecule	Homo sapiens	62-65
11093135-7	2000	Finally, reconstitution of TCR-negative Jurkat T cells with a CD8-CD3zeta chain chimera demonstrated that the cytoplasmic region of the CD3zeta chain was sufficient to couple ganglioside-mediated TTx binding to T cell activation.	Gangliosides	175-186	CD247 molecule	Homo sapiens	66-79
11093135-7	2000	Finally, reconstitution of TCR-negative Jurkat T cells with a CD8-CD3zeta chain chimera demonstrated that the cytoplasmic region of the CD3zeta chain was sufficient to couple ganglioside-mediated TTx binding to T cell activation.	Gangliosides	175-186	CD247 molecule	Homo sapiens	136-149
11054805-2	2000	We employed an embryonal carcinoma stem cell line P19 as an in vitro model to investigate the expression of gangliosides during neuronal development.	Gangliosides	108-120	l(1)20Ca	Drosophila melanogaster	50-53
11054805-6	2000	After P19 cells were committed to differentiation, the synthesis of complex gangliosides was elevated more than 20-fold, coinciding with the stage of neurite outgrowth.	Gangliosides	76-88	l(1)20Ca	Drosophila melanogaster	6-9
11054805-11	2000	Our data demonstrate that the expression of gangliosides in P19 cells during RA-induced neuronal differentiation resembles that of the in vivo development of the vertebrate brain, and hence validates it as an in vitro model for investigating the function of gangliosides in neuronal development.	Gangliosides	44-56	l(1)20Ca	Drosophila melanogaster	60-63
11054805-11	2000	Our data demonstrate that the expression of gangliosides in P19 cells during RA-induced neuronal differentiation resembles that of the in vivo development of the vertebrate brain, and hence validates it as an in vitro model for investigating the function of gangliosides in neuronal development.	Gangliosides	258-270	l(1)20Ca	Drosophila melanogaster	60-63
10944523-0	2000	Involvement of gangliosides in glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule TAG-1 signaling in lipid rafts.	Gangliosides	15-27	contactin 2	Rattus norvegicus	101-106
10944523-1	2000	The association of ganglioside GD3 with TAG-1, a glycosylphosphatidylinositol-anchored neuronal cell adhesion molecule, was examined by coimmunoprecipitation experiments.	Gangliosides	19-30	contactin 2	Rattus norvegicus	40-45
10944523-2	2000	Previously, we have shown that the anti-ganglioside GD3 antibody (R24) immunoprecipitated the Src family kinase Lyn from the rat cerebellum, and R24 treatment of primary cerebellar cultures induced Lyn activation and rapid tyrosine phosphorylation of an 80-kDa protein (p80).	Gangliosides	40-51	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	112-115
10944523-2	2000	Previously, we have shown that the anti-ganglioside GD3 antibody (R24) immunoprecipitated the Src family kinase Lyn from the rat cerebellum, and R24 treatment of primary cerebellar cultures induced Lyn activation and rapid tyrosine phosphorylation of an 80-kDa protein (p80).	Gangliosides	40-51	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	198-201
10944523-2	2000	Previously, we have shown that the anti-ganglioside GD3 antibody (R24) immunoprecipitated the Src family kinase Lyn from the rat cerebellum, and R24 treatment of primary cerebellar cultures induced Lyn activation and rapid tyrosine phosphorylation of an 80-kDa protein (p80).	Gangliosides	40-51	TATA-box binding protein associated factor 6	Rattus norvegicus	270-273
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	Gangliosides	21-32	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-8
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	Gangliosides	92-104	matrix metallopeptidase 11	Mus musculus	0-4
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	Gangliosides	92-104	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-8
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	Gangliosides	261-273	matrix metallopeptidase 11	Mus musculus	0-4
11059835-1	2000	mST3GalV synthesizes ganglioside GM3, the precursor for simple and complex a- and b- series gangliosides, and the expression and regulation of mST3GalV (CMP-NeuAc: lactosylceramide alpha2,3-sialyltransferase) activity is central to the production of almost all gangliosides, a class of glycosphingolipids implicated in variety of cellular processes such as transmembrane signaling, synaptic transmission, specialized membrane domain formation and cell-cell interactions.	Gangliosides	261-273	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-8
11023989-9	2000	These results show that mitochondria are a key destination for apoptogenic GD3 ganglioside along the lipid pathway to programmed cell death and indicate that relevant GD3 targets are under bcl-2 control.	Gangliosides	79-90	GRDX	Homo sapiens	75-78
11023989-9	2000	These results show that mitochondria are a key destination for apoptogenic GD3 ganglioside along the lipid pathway to programmed cell death and indicate that relevant GD3 targets are under bcl-2 control.	Gangliosides	79-90	GRDX	Homo sapiens	167-170
11023989-9	2000	These results show that mitochondria are a key destination for apoptogenic GD3 ganglioside along the lipid pathway to programmed cell death and indicate that relevant GD3 targets are under bcl-2 control.	Gangliosides	79-90	BCL2 apoptosis regulator	Homo sapiens	189-194
10962439-1	2000	We previously established a rat F-11 cell line whose expression of ganglioside GD3 was inhibited by stable transfection of the anti-sense vector against the GD3-synthase gene, showing that specific inhibition of GD3-synthase expression in tumor cells greatly reduced their growth rate in nude mice.	Gangliosides	67-78	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	157-169
11425192-3	2000	Of the two anti-ganglioside antibodies tested, only the anti-GD3 antibody resulted in a significant (p<0.005) inhibition of cell proliferation as measured by thymidine incorporation and Brd-U labeling, after 24h incubation.	Gangliosides	16-27	GRDX	Homo sapiens	61-64
11425192-6	2000	The selective effect of anti-GD3 antibodies as contrasted to the inactivity of anti-GM2 antibodies suggests a possible role for ganglioside GD3 in tumor cell proliferation.	Gangliosides	128-139	GRDX	Homo sapiens	29-32
11425192-6	2000	The selective effect of anti-GD3 antibodies as contrasted to the inactivity of anti-GM2 antibodies suggests a possible role for ganglioside GD3 in tumor cell proliferation.	Gangliosides	128-139	GRDX	Homo sapiens	140-143
10962439-1	2000	We previously established a rat F-11 cell line whose expression of ganglioside GD3 was inhibited by stable transfection of the anti-sense vector against the GD3-synthase gene, showing that specific inhibition of GD3-synthase expression in tumor cells greatly reduced their growth rate in nude mice.	Gangliosides	67-78	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	212-224
10962439-10	2000	These results demonstrate that suppression of GD3-synthase expression, which results primarily in a marked decrease in the concentration of ganglioside GD3, greatly reduces cell spreading, invasion and both the incidence and growth rate of experimental metastasis of F-11 cells.	Gangliosides	140-151	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	46-58
12687181-7	2000	It has been shown that two minor milk phospholipids, similarly to the previously described GM1, GM3 and GD3 gangliosides contain residue of sialic acid, but in conrast to the latter lipids, they can not be oxidized with sodium periodate; alkaline methanolysis of them results in formation of 4 and 5 products respectively, while hydrolysis of the gangliosides gives only one or two products.	Gangliosides	108-120	GRDX	Homo sapiens	104-107
11029062-7	2000	Infection of B6A4C1 cells with vaccinia virus constructs expressing constitutively active Rho family members Cdc42 and Rac restores antigen-stimulated degranulation, and active Cdc42 (but not active Rac) restores ganglioside and GPI expression.	Gangliosides	213-224	cell division cycle 42	Rattus norvegicus	109-114
10998569-0	2000	Ganglioside molecular species containing C18- and C20-sphingosine in mammalian nervous tissues and neuronal cell cultures.	Gangliosides	0-11	Bardet-Biedl syndrome 9	Homo sapiens	41-44
10998569-4	2000	A specific characteristic of CNS gangliosides is the structure of their long-chain base (LCB).	Gangliosides	33-45	clathrin light chain B	Homo sapiens	89-92
10998569-5	2000	In fact, considering all the mammalian cell sphingolipids, gangliosides, sulphatides, neutral glycosphingolipids, sphingomyelin and ceramides, it would seem that while the LCB with 18 carbons is the main component of all sphingolipids, only CNS gangliosides contain significant amounts of LCB with 20 carbons.	Gangliosides	59-71	clathrin light chain B	Homo sapiens	172-175
10998569-5	2000	In fact, considering all the mammalian cell sphingolipids, gangliosides, sulphatides, neutral glycosphingolipids, sphingomyelin and ceramides, it would seem that while the LCB with 18 carbons is the main component of all sphingolipids, only CNS gangliosides contain significant amounts of LCB with 20 carbons.	Gangliosides	245-257	clathrin light chain B	Homo sapiens	172-175
10998569-6	2000	C18-Sphingosine is always present in cell gangliosides; the individual ganglioside species containing C18-sphingosine increase during cell differentiation then remain constant during cell aging.	Gangliosides	42-54	Bardet-Biedl syndrome 9	Homo sapiens	0-3
10998569-6	2000	C18-Sphingosine is always present in cell gangliosides; the individual ganglioside species containing C18-sphingosine increase during cell differentiation then remain constant during cell aging.	Gangliosides	42-53	Bardet-Biedl syndrome 9	Homo sapiens	0-3
10998569-8	2000	In this review we discuss the chemistry, physico-chemistry and metabolism of ganglioside species differing in LCB length and introduce the hypothesis that the varying ratio between C18- and C20-gangliosides during CNS development and aging can be instrumental in modulating membrane domain organisation and cell properties.	Gangliosides	77-88	clathrin light chain B	Homo sapiens	110-113
10998569-8	2000	In this review we discuss the chemistry, physico-chemistry and metabolism of ganglioside species differing in LCB length and introduce the hypothesis that the varying ratio between C18- and C20-gangliosides during CNS development and aging can be instrumental in modulating membrane domain organisation and cell properties.	Gangliosides	77-88	Bardet-Biedl syndrome 9	Homo sapiens	181-184
11034553-0	2000	Enhanced transcription of the s-adenosylhomocysteine hydrolase gene precedes Epstein-Barr virus lytic gene activation in ganglioside-stimulated lymphoma cells.	Gangliosides	121-132	adenosylhomocysteinase	Homo sapiens	30-62
11078160-0	2000	Peripheral neuropathy associated with anti-GM2 ganglioside antibodies: clinical and immunopathological studies.	Gangliosides	47-58	cytochrome b5 domain containing 2	Mus musculus	43-46
11191112-4	2000	The target antigen for this study is the ganglioside GD3, which is highly expressed on metastatic melanoma with only minor immunologic cross-reaction with normal tissues.	Gangliosides	41-52	GRDX	Homo sapiens	53-56
10951263-0	2000	Gangliosides block keratinocyte binding to fibronectin through carbohydrate-carbohydrate binding to the alpha5 subunit of alpha5beta1	Gangliosides	0-12	fibronectin 1	Homo sapiens	43-54
10949532-1	2000	The hypothesis has been proposed that the GD3 ganglioside-like lipopolysaccharide (LPS) is essential for and functions in the development of Guillain-Barre syndrome (GBS) and Miller Fisher syndrome (MFS) subsequent to Campylobacter jejuni enteritis.	Gangliosides	46-57	GRDX	Homo sapiens	42-45
10987178-0	2000	Immunohistochemically visualized localisation of gangliosides Glac2 (GD3) and Gtri2 (GD2) in cells of human intracranial tumors.	Gangliosides	49-61	GRDX	Homo sapiens	69-72
10987178-11	2000	By comparison with GFAP expression in gliomas and vimentin in meningiomas, the colocalisation of gangliosides and intermediary filament proteins is supposed.	Gangliosides	97-109	glial fibrillary acidic protein	Homo sapiens	19-23
10987178-11	2000	By comparison with GFAP expression in gliomas and vimentin in meningiomas, the colocalisation of gangliosides and intermediary filament proteins is supposed.	Gangliosides	97-109	vimentin	Homo sapiens	50-58
10903477-6	2000	Cellular gangliosides were detected in the culture supernatant by HPTLC autoradiography, confirming an active shedding rate of 3% of cellular gangliosides/24 h. CABA I cell membranes also express caveolin-1, a characteristic protein marker for caveolae, which was detected by flow cytometric analysis and by Western blotting in both the cell membranes and the isolated membrane vesicles.	Gangliosides	9-21	caveolin 1	Homo sapiens	196-206
10941908-1	2000	KM871 is a chimeric antibody recognizing ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin.	Gangliosides	41-52	GRDX	Homo sapiens	53-56
10941908-1	2000	KM871 is a chimeric antibody recognizing ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin.	Gangliosides	84-96	GRDX	Homo sapiens	53-56
10941909-4	2000	In previous work, we found that an unmodified anti-ganglioside mouse IgG3 monoclonal antibody (mAb), 3F8, could successfully treat clinical tumors in humans and experimental tumors in rats but not experimental tumors in mice.	Gangliosides	51-62	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	69-73
10866823-5	2000	The interaction between the ganglioside derivative and CAV1 was a time-dependent, transient process so that CAV1 cross-linking to GM3 was hardly detectable after a 24-h chase followed the pulse time.	Gangliosides	28-39	caveolin 1	Homo sapiens	55-59
10880242-0	2000	Ganglioside control over IL-4 priming and cytokine production in activated T cells.	Gangliosides	0-11	interleukin 4	Mus musculus	25-29
10880242-3	2000	These studies determined that treatment of T cells with the naturally occurring ganglioside GM3 inhibited the production of IL-4 without affecting the production of IL-2.	Gangliosides	80-91	granulocyte macrophage antigen 3	Mus musculus	92-95
10880242-3	2000	These studies determined that treatment of T cells with the naturally occurring ganglioside GM3 inhibited the production of IL-4 without affecting the production of IL-2.	Gangliosides	80-91	interleukin 4	Mus musculus	124-128
10880242-5	2000	The inhibitory effects of GM3 could be overcome by treatment with thapsigargin or ionomycin, suggesting ganglioside regulation occurs upstream of activation-induced calcium mobilization.	Gangliosides	104-115	granulocyte macrophage antigen 3	Mus musculus	26-29
10880242-7	2000	Our results indicate that activities by membrane gangliosides can influence the cytokine programs in CD4(+)T cells, possibly through the modulation of calcium responses induced by T cell activation.	Gangliosides	49-61	CD4 antigen	Mus musculus	101-104
10866823-5	2000	The interaction between the ganglioside derivative and CAV1 was a time-dependent, transient process so that CAV1 cross-linking to GM3 was hardly detectable after a 24-h chase followed the pulse time.	Gangliosides	28-39	caveolin 1	Homo sapiens	108-112
10838182-6	2000	Most of the ganglioside bands could be analyzed, and they were identified as GM3, GM2, SPG, GM1a, GD3, S-i (sialyl-i ganglioside) and GD1a.	Gangliosides	12-23	GRDX	Homo sapiens	98-101
10858540-3	2000	Twenty-four genes with assigned functions were confirmed to be induced by the ganglioside in reverse Northern blot experiments covering e.g. protein kinase B, phospholipase C, the MAP-kinase ERK3, the transcription factors YY1, DR1 and NSEP, the membrane traffic protein TAP, and the nuclear export protein CRM1.	Gangliosides	78-89	mitogen-activated protein kinase 12	Homo sapiens	191-195
10858540-3	2000	Twenty-four genes with assigned functions were confirmed to be induced by the ganglioside in reverse Northern blot experiments covering e.g. protein kinase B, phospholipase C, the MAP-kinase ERK3, the transcription factors YY1, DR1 and NSEP, the membrane traffic protein TAP, and the nuclear export protein CRM1.	Gangliosides	78-89	YY1 transcription factor	Homo sapiens	223-226
10858540-3	2000	Twenty-four genes with assigned functions were confirmed to be induced by the ganglioside in reverse Northern blot experiments covering e.g. protein kinase B, phospholipase C, the MAP-kinase ERK3, the transcription factors YY1, DR1 and NSEP, the membrane traffic protein TAP, and the nuclear export protein CRM1.	Gangliosides	78-89	down-regulator of transcription 1	Homo sapiens	228-231
10858540-3	2000	Twenty-four genes with assigned functions were confirmed to be induced by the ganglioside in reverse Northern blot experiments covering e.g. protein kinase B, phospholipase C, the MAP-kinase ERK3, the transcription factors YY1, DR1 and NSEP, the membrane traffic protein TAP, and the nuclear export protein CRM1.	Gangliosides	78-89	exportin 1	Homo sapiens	307-311
10959489-1	2000	The influence of GM1 on the neuritogenic phase of neuronal differentiation has been highlighted in recent reports showing upregulation of this ganglioside in the plasma and nuclear membranes concomitant with axonogenesis.	Gangliosides	143-154	coenzyme Q10A	Mus musculus	17-20
10812068-1	2000	The acetyl-CoA transporter gene (Acatn) encodes a hydrophobic, multitransmembrane protein that is involved in the process of O-acetylation of sialic acid residues on gangliosides.	Gangliosides	166-178	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	4-31
10841521-2	2000	A novel, humanized anti-ganglioside-GD(2)-IL-2 immunocytokine (hu14.18-IL-2) induced CD8(+) T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a process that required help by CD4(+) T cells and was mediated by the CD40/CD40 ligand (CD40L) interaction.	Gangliosides	24-35	interleukin 2	Mus musculus	42-46
10841521-2	2000	A novel, humanized anti-ganglioside-GD(2)-IL-2 immunocytokine (hu14.18-IL-2) induced CD8(+) T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a process that required help by CD4(+) T cells and was mediated by the CD40/CD40 ligand (CD40L) interaction.	Gangliosides	24-35	interleukin 2	Mus musculus	71-75
10841521-2	2000	A novel, humanized anti-ganglioside-GD(2)-IL-2 immunocytokine (hu14.18-IL-2) induced CD8(+) T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a process that required help by CD4(+) T cells and was mediated by the CD40/CD40 ligand (CD40L) interaction.	Gangliosides	24-35	CD4 antigen	Mus musculus	209-212
10841521-2	2000	A novel, humanized anti-ganglioside-GD(2)-IL-2 immunocytokine (hu14.18-IL-2) induced CD8(+) T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a process that required help by CD4(+) T cells and was mediated by the CD40/CD40 ligand (CD40L) interaction.	Gangliosides	24-35	CD40 antigen	Mus musculus	248-252
10841521-2	2000	A novel, humanized anti-ganglioside-GD(2)-IL-2 immunocytokine (hu14.18-IL-2) induced CD8(+) T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a process that required help by CD4(+) T cells and was mediated by the CD40/CD40 ligand (CD40L) interaction.	Gangliosides	24-35	CD40 ligand	Mus musculus	253-264
10841521-2	2000	A novel, humanized anti-ganglioside-GD(2)-IL-2 immunocytokine (hu14.18-IL-2) induced CD8(+) T cells to eradicate established pulmonary metastases of B78-D14 murine melanoma, in a process that required help by CD4(+) T cells and was mediated by the CD40/CD40 ligand (CD40L) interaction.	Gangliosides	24-35	CD40 ligand	Mus musculus	266-271
10812068-1	2000	The acetyl-CoA transporter gene (Acatn) encodes a hydrophobic, multitransmembrane protein that is involved in the process of O-acetylation of sialic acid residues on gangliosides.	Gangliosides	166-178	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	33-38
10739654-3	2000	Furthermore, depletion of ganglioside by sialidase gene transfection appeared to increase EGF receptor (EGFR) autophosphorylation.	Gangliosides	26-37	epidermal growth factor receptor	Homo sapiens	90-102
10884613-3	2000	Human CD1b, which is only distantly related to the CD1d molecules, can present mammalian glycosphingolipids (gangliosides) to autoreactive T-cell clones derived from multiple sclerosis patients.	Gangliosides	109-121	CD1b molecule	Homo sapiens	6-10
10884613-3	2000	Human CD1b, which is only distantly related to the CD1d molecules, can present mammalian glycosphingolipids (gangliosides) to autoreactive T-cell clones derived from multiple sclerosis patients.	Gangliosides	109-121	CD1d molecule	Homo sapiens	51-55
10837887-1	2000	The ganglioside GM1 is a glycosphingolipid which enhances process formation of several neuronal lines and potentiates some growth factor-mediated responses.	Gangliosides	4-15	coenzyme Q10A	Mus musculus	16-19
10739654-3	2000	Furthermore, depletion of ganglioside by sialidase gene transfection appeared to increase EGF receptor (EGFR) autophosphorylation.	Gangliosides	26-37	epidermal growth factor receptor	Homo sapiens	104-108
10681573-1	2000	A rat pheochromocytoma cell line (PC12) transfected with ganglioside GD3 synthase gene showed a marked change in the ganglioside profile and enhanced proliferation and no response of neurite extension to nerve growth factor (NGF) stimulation.	Gangliosides	57-68	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	69-81
10767333-3	2000	To determine if ganglioside accumulation is a crucial factor in neuropathogenesis, we bred NP-C model mice with mice carrying a targeted mutation in GalNAcT, the gene encoding the beta-1-4GalNAc transferase responsible for the synthesis of GM2 and complex gangliosides.	Gangliosides	256-268	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	149-156
10737630-1	2000	GD3 synthase (Sial-T2) is a key enzyme of ganglioside synthesis that, in concert with GM2 synthase (GalNAc-T), regulates the ratio of a- and b-pathway gangliosides.	Gangliosides	42-53	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Gallus gallus	14-21
10737630-1	2000	GD3 synthase (Sial-T2) is a key enzyme of ganglioside synthesis that, in concert with GM2 synthase (GalNAc-T), regulates the ratio of a- and b-pathway gangliosides.	Gangliosides	151-163	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Gallus gallus	14-21
10863722-2	2000	DEVELOPMENT: Antibodies to MAG or gangliosides have been described in neuropathies associated to monoclonal gammopathy or inflammatory polyneuropathies, such as Guillain-Barre syndrome or multifocal motor neuropathy.	Gangliosides	34-46	myelin associated glycoprotein	Homo sapiens	27-30
11201796-1	2000	In view of the increasing evidence that gangliosides in membrane microdomains or rafts are closely associated with various signal transducing molecules including Src family kinases, we compared rafts in two subclones of 3LL mouse lung carcinoma cell line, J18 and J5, characterized by high and very low GM3 ganglioside contents, respectively.	Gangliosides	40-52	Rous sarcoma oncogene	Mus musculus	162-165
11201796-1	2000	In view of the increasing evidence that gangliosides in membrane microdomains or rafts are closely associated with various signal transducing molecules including Src family kinases, we compared rafts in two subclones of 3LL mouse lung carcinoma cell line, J18 and J5, characterized by high and very low GM3 ganglioside contents, respectively.	Gangliosides	40-51	Rous sarcoma oncogene	Mus musculus	162-165
10681573-1	2000	A rat pheochromocytoma cell line (PC12) transfected with ganglioside GD3 synthase gene showed a marked change in the ganglioside profile and enhanced proliferation and no response of neurite extension to nerve growth factor (NGF) stimulation.	Gangliosides	117-128	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	69-81
10685665-10	2000	Gangliosides isolated from tumor supernatants blocked the production of IL-2 and IFN-gamma in response to ionomycin plus phorbol myristate acetate stimulation.	Gangliosides	0-12	interleukin 2	Homo sapiens	72-76
10653652-2	2000	The glycolipid transfer protein (23-24 kDa, pI 9.0) catalyzes the high specificity transfer of lipids that have sugars beta-linked to either a ceramide or a diacylglycerol backbone, such as simple glycolipids and gangliosides, but not the transfer of phospholipids, cholesterol, or cholesterol esters.	Gangliosides	213-225	glycolipid transfer protein	Homo sapiens	4-31
10685665-10	2000	Gangliosides isolated from tumor supernatants blocked the production of IL-2 and IFN-gamma in response to ionomycin plus phorbol myristate acetate stimulation.	Gangliosides	0-12	interferon gamma	Homo sapiens	81-90
10685665-11	2000	These gangliosides also inhibited stimulus-dependent activation and nuclear accumulation of NFkappaB.	Gangliosides	6-18	nuclear factor kappa B subunit 1	Homo sapiens	92-100
10685665-12	2000	Coculture experiments demonstrated that renal cell carcinoma lines known to express gangliosides could inhibit the activation of NFkappaB in normal T cells and the Jurkat T-cell line.	Gangliosides	84-96	nuclear factor kappa B subunit 1	Homo sapiens	129-137
10731682-0	2000	Crystallization and preliminary X-ray diffraction analysis of the extracellular domain of the cell surface antigen CD38 complexed with ganglioside.	Gangliosides	135-146	CD38 molecule	Homo sapiens	115-119
10731682-2	2000	The extracellular catalytic domain of CD38 was expressed as a fusion protein with maltose-binding protein, and was crystallized in the complex with a ganglioside, G(T1b), one of the possible physiological inhibitors of this ectoenzyme.	Gangliosides	150-161	CD38 molecule	Homo sapiens	38-42
10950141-1	2000	Several gangliosides such as GM2, GD2, and GD3 have been thought of as target molecules for active or passive immunotherapy of human cancers because of their dominant expression on the tumor cell surface, especially in tumors of neuroectodermal origin.	Gangliosides	8-20	GRDX	Homo sapiens	43-46
10690709-4	2000	The major ganglioside in the later human milk, GM3 (27.7%), was only a minor component in the colostrum, cow"s milk and infant formulas (3.3, 2.8 and 0.4-2.6%, respectively).	Gangliosides	10-21	Weaning weight-maternal milk	Bos taurus	41-45
10965123-1	2000	Rat acetyl-CoA transporter gene (Acatn) encodes a hydrophobic multi-transmembrane protein involved in the O-acetylation of gangliosides.	Gangliosides	123-135	solute carrier family 33 member 1	Rattus norvegicus	4-31
10965123-1	2000	Rat acetyl-CoA transporter gene (Acatn) encodes a hydrophobic multi-transmembrane protein involved in the O-acetylation of gangliosides.	Gangliosides	123-135	solute carrier family 33 member 1	Rattus norvegicus	33-38
10690709-0	2000	Variation of the ganglioside compositions of human milk, cow"s milk and infant formulas.	Gangliosides	17-28	Weaning weight-maternal milk	Bos taurus	51-55
10690709-6	2000	Another four gangliosides, which were assumed to be c-series gangliosides, were detected in the colostrum and the later human milk.	Gangliosides	13-25	Weaning weight-maternal milk	Bos taurus	126-130
10690709-0	2000	Variation of the ganglioside compositions of human milk, cow"s milk and infant formulas.	Gangliosides	17-28	Weaning weight-maternal milk	Bos taurus	63-67
10690709-2	2000	The results showed that there was a drastic change in the ganglioside composition from the colostrum to later human milk, and that both the patterns and contents of gangliosides in human milk, cow"s milk and infant formulas differed markedly.	Gangliosides	165-177	Weaning weight-maternal milk	Bos taurus	187-191
10690709-6	2000	Another four gangliosides, which were assumed to be c-series gangliosides, were detected in the colostrum and the later human milk.	Gangliosides	61-73	Weaning weight-maternal milk	Bos taurus	126-130
10690709-2	2000	The results showed that there was a drastic change in the ganglioside composition from the colostrum to later human milk, and that both the patterns and contents of gangliosides in human milk, cow"s milk and infant formulas differed markedly.	Gangliosides	165-177	Weaning weight-maternal milk	Bos taurus	187-191
10690709-9	2000	The variation of the gangliosides in human and cow"s milk, and infant formulas might have some biological significance regarding neonatal brain development, allergies, infant growth and non-immunoglobulin prophylactic activities against some bacterial toxins.	Gangliosides	21-33	Weaning weight-maternal milk	Bos taurus	53-57
10852128-2	2000	This article summarizes therapeutic efficacy and immune mechanisms involved in targeting interleukin-2 (IL-2) to neuroectodermal tumors using ganglioside GD2-specific antibody-IL-2 fusion protein (ch14.18-IL-2).	Gangliosides	142-153	interleukin 2	Mus musculus	89-102
10664069-2	2000	The GM3 expression was highly variable from cell to cell and the distribution of the ganglioside on the positive cells appeared punctate.	Gangliosides	85-96	granulocyte macrophage antigen 3	Mus musculus	4-7
10852128-2	2000	This article summarizes therapeutic efficacy and immune mechanisms involved in targeting interleukin-2 (IL-2) to neuroectodermal tumors using ganglioside GD2-specific antibody-IL-2 fusion protein (ch14.18-IL-2).	Gangliosides	142-153	interleukin 2	Mus musculus	104-108
10648029-0	2000	Anti-ganglioside antibodies in a large cohort of European patients with systemic lupus erythematosus: clinical, serological, and HLA class II gene associations.	Gangliosides	5-16	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	129-132
10731661-0	2000	Ganglioside GT1b in rat brain binds to p58, a brain-specific sodium-dependent inorganic phosphate cotransporter: expression cloning with a specific monoclonal antibody to ganglioside GT1b-binding protein.	Gangliosides	0-11	DNA primase subunit 2	Rattus norvegicus	39-42
10731661-0	2000	Ganglioside GT1b in rat brain binds to p58, a brain-specific sodium-dependent inorganic phosphate cotransporter: expression cloning with a specific monoclonal antibody to ganglioside GT1b-binding protein.	Gangliosides	171-182	DNA primase subunit 2	Rattus norvegicus	39-42
10648029-2	2000	OBJECTIVE: To assay anti-ganglioside antibodies (aGM1) in sera of a large cohort of European patients with systemic lupus erythematosus (SLE) to define the prevalence of these autoantibodies in SLE; to evaluate the association of aGM1 with clinical manifestations and other autoantibodies found in SLE; and to search for aGM1 association with HLA class II alleles.	Gangliosides	25-36	immunoglobulin heavy constant mu	Homo sapiens	49-53
11341466-0	2000	Human interferon-gamma enhances expression of ganglioside GM2 on human lung cancer cells and their susceptibility for antiganglioside GM2 monoclonal antibody-dependent cellular cytotoxicity.	Gangliosides	46-57	interferon gamma	Homo sapiens	6-22
10963436-1	2000	Gangliosides induce apoptosis in the cells of the IL-2-dependent cytotoxic mouse line CTLL-2.	Gangliosides	0-12	interleukin 2	Mus musculus	50-54
10963436-2	2000	Upon incubation with gangliosides for 24 h, their effect resulting in appearance of apoptotic cells, falls in a series GM2 > GM3 > GM1 > GD1a > GD1b > GT1b.	Gangliosides	21-33	cytochrome b5 domain containing 2	Mus musculus	119-122
10963436-2	2000	Upon incubation with gangliosides for 24 h, their effect resulting in appearance of apoptotic cells, falls in a series GM2 > GM3 > GM1 > GD1a > GD1b > GT1b.	Gangliosides	21-33	granulocyte macrophage antigen 3	Mus musculus	128-131
11341466-2	2000	In this study, we demonstrated that human interferon-gamma (HuIFN-gamma) enhanced the expression of ganglioside GM2 (GM2), which is a kind of tumor-associated antigen substantially expressed in human lung cancer and that human lung cancer cells expressing GM2 became more susceptible to anti-GM2 monoclonal antibody (mAb)-dependent tumor cell killing mediated by human effector cells after HuIFN-gamma treatment.	Gangliosides	100-111	interferon gamma	Homo sapiens	42-58
10574921-4	1999	Gangliosides induced production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) and expression of cyclooxygenase-2 (COX-2).	Gangliosides	0-12	tumor necrosis factor	Rattus norvegicus	57-84
10633069-6	1999	We reduced this unnicked protein and used its binding to ganglioside in a lipid layer to produce helical tubular crystals of unnicked botulinum neurotoxin type B in its disulfide-reduced state.	Gangliosides	57-68	neurotoxin	Clostridium botulinum	144-154
10608819-0	1999	Enhanced binding of the neural siglecs, myelin-associated glycoprotein and Schwann cell myelin protein, to Chol-1 (alpha-series) gangliosides and novel sulfated Chol-1 analogs.	Gangliosides	129-141	myelin associated glycoprotein	Homo sapiens	40-70
10608819-3	1999	The alpha-series gangliosides displayed enhanced potency for MAG- and SMP-mediated cell adhesion (GQ1balpha > GT1aalpha, GD1alpha > GT1b, GD1a >> GM1 (nonbinding)), whereas sialoadhesin-mediated adhesion was comparable with alpha-series and non-alpha-series gangliosides.	Gangliosides	17-29	myelin associated glycoprotein	Homo sapiens	61-64
10608819-3	1999	The alpha-series gangliosides displayed enhanced potency for MAG- and SMP-mediated cell adhesion (GQ1balpha > GT1aalpha, GD1alpha > GT1b, GD1a >> GM1 (nonbinding)), whereas sialoadhesin-mediated adhesion was comparable with alpha-series and non-alpha-series gangliosides.	Gangliosides	17-29	sialic acid binding Ig like lectin 1	Homo sapiens	185-197
10574921-4	1999	Gangliosides induced production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) and expression of cyclooxygenase-2 (COX-2).	Gangliosides	0-12	tumor necrosis factor	Rattus norvegicus	86-95
10574921-4	1999	Gangliosides induced production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) and expression of cyclooxygenase-2 (COX-2).	Gangliosides	0-12	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	115-131
10574921-4	1999	Gangliosides induced production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) and expression of cyclooxygenase-2 (COX-2).	Gangliosides	0-12	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	133-138
10562533-3	1999	CCR5 associates with membrane raft microdomains, and its polarization parallels redistribution of raft molecules, including the raft-associated ganglioside GM1, glycosylphosphatidylinositol-anchored green fluorescent protein and ephrinB1, to the leading edge.	Gangliosides	144-155	C-C motif chemokine receptor 5	Homo sapiens	0-4
10521808-0	1999	Suppression by ganglioside GD1A of migration capability, adhesion to vitronectin and metastatic potential of highly metastatic FBJ-LL cells.	Gangliosides	15-26	vitronectin	Mus musculus	69-80
10632368-2	1999	Recently, a fusion protein consisting of GM-CSF and chimeric human/mouse anti-ganglioside G(D2) antibody Ch14.18 (Ch14.18-GM-CSF) has been generated to improve the effectiveness of immunotherapy by directing GM-CSF to the tumor microenvironment and prolonging its relatively short half-life.	Gangliosides	78-89	colony stimulating factor 2	Homo sapiens	122-128
10632368-2	1999	Recently, a fusion protein consisting of GM-CSF and chimeric human/mouse anti-ganglioside G(D2) antibody Ch14.18 (Ch14.18-GM-CSF) has been generated to improve the effectiveness of immunotherapy by directing GM-CSF to the tumor microenvironment and prolonging its relatively short half-life.	Gangliosides	78-89	colony stimulating factor 2	Homo sapiens	122-128
10537325-5	1999	We stably transfected the EPEN cells with the cDNA for N-acetylgalactosaminyl transferase, a key enzyme for the synthesis of complex gangliosides.	Gangliosides	133-145	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	55-89
10537325-6	1999	In addition to G(M3), the transfected cell line (EPEN-GNT) expressed complex gangliosides G(M2), G(M1), and G(D1a).	Gangliosides	77-89	glucosaminyl (N-acetyl) transferase family member 7	Mus musculus	54-57
10537325-9	1999	The synthesis of complex gangliosides in the EPEN-GNT tumor cells also stimulated vascularization in an in vivo Matrigel assay for angiogenesis.	Gangliosides	25-37	glucosaminyl (N-acetyl) transferase family member 7	Mus musculus	50-53
10536964-8	1999	A corresponding transient increase of mRNA for GalNAcT, the key enzyme in the production of these latter gangliosides, could be detected preceding the expression of these gangliosides and the FcepsilonRI by RT-PCR.	Gangliosides	105-117	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	47-54
10536964-8	1999	A corresponding transient increase of mRNA for GalNAcT, the key enzyme in the production of these latter gangliosides, could be detected preceding the expression of these gangliosides and the FcepsilonRI by RT-PCR.	Gangliosides	171-183	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	47-54
10546161-5	1999	Further, the cytotoxicity mediated by recombinant canine IFN-gamma-activated canine PAMs, in combination with anti-GD2 ganglioside mAb 14.G2a, enhanced melanoma cytotoxicity above that seen with mAb 14.G2a alone.	Gangliosides	119-130	interferon gamma	Canis lupus familiaris	57-66
10490967-3	1999	The major FBL-3 ganglioside was identified as GM1b by mass spectrometry.	Gangliosides	16-27	F-box and leucine-rich repeat protein 2	Mus musculus	10-15
10490967-5	1999	Immunosuppression by FBL-3 gangliosides was potent; 5-20 microM inhibited the tumor-specific secondary proliferative response (80-100%) and suppressed the generation of tumor-specific CTLs (97% reduction of FBL-3 cell lysis at an E:T ratio of 100:1).	Gangliosides	27-39	F-box and leucine-rich repeat protein 2	Mus musculus	21-26
10490967-5	1999	Immunosuppression by FBL-3 gangliosides was potent; 5-20 microM inhibited the tumor-specific secondary proliferative response (80-100%) and suppressed the generation of tumor-specific CTLs (97% reduction of FBL-3 cell lysis at an E:T ratio of 100:1).	Gangliosides	27-39	F-box and leucine-rich repeat protein 2	Mus musculus	207-212
10490967-6	1999	In vivo, coinjection of 10 nmol of FBL-3 gangliosides with a primary FBL-3 cell immunization led to a reduced response to a secondary challenge (the increase in the draining popliteal lymph node mass, cell number, and lymphocyte thymidine incorporation were lowered by 70, 69, and 72%, respectively).	Gangliosides	41-53	F-box and leucine-rich repeat protein 2	Mus musculus	35-40
10490967-6	1999	In vivo, coinjection of 10 nmol of FBL-3 gangliosides with a primary FBL-3 cell immunization led to a reduced response to a secondary challenge (the increase in the draining popliteal lymph node mass, cell number, and lymphocyte thymidine incorporation were lowered by 70, 69, and 72%, respectively).	Gangliosides	41-53	F-box and leucine-rich repeat protein 2	Mus musculus	69-74
10490967-7	1999	Coinjection of gangliosides with a secondary tumor challenge led to a 61, 74, and 42% reduction of the increase in lymph node mass, cell number, and thymidine uptake and a 63-74% inhibition of the increase of draining lymph node T cells (CD3+), B cells (CD19+), and dendritic cells/macrophages (Mac-3+).	Gangliosides	15-27	lysosomal-associated membrane protein 2	Mus musculus	295-300
10491412-4	1999	The inhibitory agent has several features characteristic of a ganglioside, including sensitivity to neuraminidase but not protease treatment; hydrophobicity; and molecular weight less than 3 kDa.	Gangliosides	62-73	neuraminidase 1	Homo sapiens	100-113
10491412-6	1999	Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.	Gangliosides	0-12	nuclear factor kappa B subunit 1	Homo sapiens	118-126
10491412-6	1999	Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.	Gangliosides	0-12	interleukin 2	Bos taurus	195-199
10570973-4	1999	Transfection of mouse Acatn cDNA into HeLa/GT3+ cells resulted in significant increase in the amount of 9-O-acetylated gangliosides, suggesting that Acatn does play an important role in the acetylation of gangliosides.	Gangliosides	119-131	solute carrier family 33 (acetyl-CoA transporter), member 1	Mus musculus	22-27
10570973-4	1999	Transfection of mouse Acatn cDNA into HeLa/GT3+ cells resulted in significant increase in the amount of 9-O-acetylated gangliosides, suggesting that Acatn does play an important role in the acetylation of gangliosides.	Gangliosides	119-131	solute carrier family 33 member 1	Homo sapiens	149-154
10477274-1	1999	UDP-GalNAc:lactosylceramide/GM3/GD3 beta-1,4-N-acetylgalactosaminyltransferase (GalNAc-T) transforms its acceptors into the gangliosides GA2, GM2 and GD2.	Gangliosides	124-136	Polypeptide N-acetylgalactosaminyltransferase 35A	Drosophila melanogaster	80-88
10612003-0	1999	Ganglioside expression in tissues of mice lacking the tumor necrosis factor receptor 1.	Gangliosides	0-11	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	54-86
10612003-6	1999	Reduced expression of GM1b-type gangliosides (GM1b and GalNAc-GM1b) was also found in the lungs, spleen, and thymus of the TNFRp55 knockout mice.	Gangliosides	32-44	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	123-130
10612003-8	1999	This study provides in vivo evidence that TNF signaling via the TNFRp55 is involved in the acquisition of a distinct ganglioside assembly in different mouse organs.	Gangliosides	117-128	tumor necrosis factor	Mus musculus	42-45
10612003-8	1999	This study provides in vivo evidence that TNF signaling via the TNFRp55 is involved in the acquisition of a distinct ganglioside assembly in different mouse organs.	Gangliosides	117-128	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	64-71
10612003-9	1999	TNFRp55 signaling seems to be especially important for the activation of the GM1b-type ganglioside biosynthetic pathway that is a unique characteristic of the mouse lymphoid tissues.	Gangliosides	87-98	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	0-7
10491412-6	1999	Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.	Gangliosides	0-12	interferon gamma	Bos taurus	204-213
10491412-6	1999	Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.	Gangliosides	76-88	nuclear factor kappa B subunit 1	Homo sapiens	118-126
10491412-6	1999	Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.	Gangliosides	76-88	interleukin 2	Bos taurus	195-199
10491412-6	1999	Gangliosides prepared from RCC supernatants, as well as the purified bovine gangliosides G(m1) and G(d1a), suppressed NFkappaB binding activity in T cells and reduced expression of the cytokines IL-2 and IFN-gamma.	Gangliosides	76-88	interferon gamma	Bos taurus	204-213
10428051-0	1999	Regulation of transmembrane signaling by ganglioside GM1: interaction of anti-GM1 with Neuro2a cells.	Gangliosides	41-52	coenzyme Q10A	Mus musculus	53-56
10478474-1	1999	Collision-induced dissociation (CID) spectra of sodium ion complexes ([M+Na]+ ions), produced by FAB-MS of methyl ester derivatives of ganglioside, indicate the length of the fatty acyl chain of the ceramide moieties without chemical degradation.	Gangliosides	135-146	FA complementation group B	Homo sapiens	97-100
10486566-5	1999	Both cholesterol and ganglioside are seen to inhibit, in an additive way, the hydrolytic activity of GPI-specific phospholipase D.	Gangliosides	21-32	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	101-129
10428051-0	1999	Regulation of transmembrane signaling by ganglioside GM1: interaction of anti-GM1 with Neuro2a cells.	Gangliosides	41-52	coenzyme Q10A	Mus musculus	78-81
10428051-1	1999	Interaction of antibodies to ganglioside GM1 with Neuro2a cells was studied to investigate the role of GM1 in cell signaling.	Gangliosides	29-40	coenzyme Q10A	Mus musculus	41-44
10399959-0	1999	Physiological concentrations of gangliosides GM1, GM2 and GM3 differentially modify basic-fibroblast-growth-factor-induced mitogenesis and the associated signalling pathway in endothelial cells.	Gangliosides	32-44	fibroblast growth factor 2	Homo sapiens	84-114
10399959-4	1999	The mitogenic effect of all 3 gangliosides was markedly reduced if the cells were washed to remove excess gangliosides from the medium before addition of bFGF.	Gangliosides	30-42	fibroblast growth factor 2	Homo sapiens	154-158
10435588-1	1999	Attenuation of epidermal growth factor receptor signaling by the ganglioside G(M3) has previously been found to involve activation of an unknown protein-tyrosine phosphatase (PTP).	Gangliosides	65-76	epidermal growth factor receptor	Homo sapiens	15-47
10435588-1	1999	Attenuation of epidermal growth factor receptor signaling by the ganglioside G(M3) has previously been found to involve activation of an unknown protein-tyrosine phosphatase (PTP).	Gangliosides	65-76	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	145-173
10435588-1	1999	Attenuation of epidermal growth factor receptor signaling by the ganglioside G(M3) has previously been found to involve activation of an unknown protein-tyrosine phosphatase (PTP).	Gangliosides	65-76	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	175-178
10393343-1	1999	In a previous paper we showed that the B-pentamer of cholera toxin (CT-B) binds with reduced binding strength to different C(1) derivatives of N-acetylneuraminic acid (NeuAc) of the natural receptor ganglioside, GM1.	Gangliosides	199-210	phosphate cytidylyltransferase 1B, choline	Homo sapiens	68-72
10360826-8	1999	FACS-analysis studies with human CD34+ cells cultured with gangliosides (GM3), erythropoietin (EPO) and stem cell factor (SCF) demonstrated a strong inhibition on cell growth.	Gangliosides	59-71	CD34 molecule	Homo sapiens	33-37
10397254-0	1999	GD3 ganglioside antibody augments tumoricidal capacity of canine blood mononuclear cells by induction of interleukin 12.	Gangliosides	4-15	GRDX	Homo sapiens	0-3
10397254-1	1999	Monoclonal antibody R24 recognizes ganglioside GD3 expressed on the cell surfaces of some tumor cells and on a subset of human T lymphocytes.	Gangliosides	35-46	GRDX	Homo sapiens	47-50
10397254-4	1999	A subset of canine monocytes, but not lymphocytes, was found to express gangliosides GD3 and GD2 as determined by the binding of monoclonal antibodies R24 and 14.G2a, respectively.	Gangliosides	72-84	GRDX	Homo sapiens	85-88
10397254-9	1999	These data indicate that monocytes can be activated for tumoricidal responses through a membrane structure associated with ganglioside GD3 triggered by the binding of R24 and that the mechanism for enhanced cytotoxicity is due to the production and secretion of IL-12.	Gangliosides	123-134	GRDX	Homo sapiens	135-138
10619706-1	1999	GM3-synthase, also known as sialyltransferase I (ST-I), catalyzes the transfer of a sialic acid residue from CMP-sialic acid onto lactosylceramide to form ganglioside GM3.	Gangliosides	155-166	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	0-12
10375594-0	1999	A novel hydrophobized GM3 ganglioside/Neisseria meningitidis outer-membrane-protein complex vaccine induces tumor protection in B16 murine melanoma.	Gangliosides	26-37	granulocyte macrophage antigen 3	Mus musculus	22-25
10375594-4	1999	B16 cell line is characterized by the predominant presence of ganglioside GM3 on the cell surface.	Gangliosides	62-73	granulocyte macrophage antigen 3	Mus musculus	74-77
10376687-4	1999	In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells.	Gangliosides	15-26	GRDX	Homo sapiens	27-30
10377449-3	1999	By disrupting the gene for a key enzyme in complex ganglioside biosynthesis (GM2/GD2 synthase; EC 2.4.1.92) we generated mice that express only simple gangliosides (GM3/GD3) and examined their central and peripheral nervous systems.	Gangliosides	51-62	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	77-93
10377449-3	1999	By disrupting the gene for a key enzyme in complex ganglioside biosynthesis (GM2/GD2 synthase; EC 2.4.1.92) we generated mice that express only simple gangliosides (GM3/GD3) and examined their central and peripheral nervous systems.	Gangliosides	151-163	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	77-93
10377449-3	1999	By disrupting the gene for a key enzyme in complex ganglioside biosynthesis (GM2/GD2 synthase; EC 2.4.1.92) we generated mice that express only simple gangliosides (GM3/GD3) and examined their central and peripheral nervous systems.	Gangliosides	151-163	granulocyte macrophage antigen 3	Mus musculus	165-168
10377449-5	1999	The pathological features of their nervous system closely resemble those reported in mice with a disrupted gene for myelin-associated glycoprotein (MAG), a myelin receptor that binds to complex brain gangliosides in vitro.	Gangliosides	200-212	myelin-associated glycoprotein	Mus musculus	116-146
10377449-5	1999	The pathological features of their nervous system closely resemble those reported in mice with a disrupted gene for myelin-associated glycoprotein (MAG), a myelin receptor that binds to complex brain gangliosides in vitro.	Gangliosides	200-212	myelin-associated glycoprotein	Mus musculus	148-151
10377449-8	1999	They also support the theory that complex gangliosides are endogenous ligands for MAG.	Gangliosides	42-54	myelin-associated glycoprotein	Mus musculus	82-85
10383637-0	1999	Tenascin-R interferes with integrin-dependent oligodendrocyte precursor cell adhesion by a ganglioside-mediated signalling mechanism.	Gangliosides	91-102	tenascin R	Mus musculus	0-10
10383637-5	1999	TN-R interacted specifically with disialoganglioside-expressing cells or immobilized gangliosides, and ganglioside treatment of TN-R substrata resulted in a delayed preOL cell detachment as a function of time.	Gangliosides	85-97	tenascin R	Mus musculus	0-4
10383637-5	1999	TN-R interacted specifically with disialoganglioside-expressing cells or immobilized gangliosides, and ganglioside treatment of TN-R substrata resulted in a delayed preOL cell detachment as a function of time.	Gangliosides	41-52	tenascin R	Mus musculus	0-4
10376687-4	1999	In particular, ganglioside GD3 biosynthesis represents an important event for the progression of apoptotic signals generated by CD95 and mediated by ceramide in hematopoietic cells.	Gangliosides	15-26	Fas cell surface death receptor	Homo sapiens	128-132
10435777-8	1999	The use of nonspecific intracellular PLA2 inhibitors (quinacrine, heparin, gangliosides, vitamin E) in animal model studies of neurological disorders in vivo has provided some useful information on tolerance, toxicity, and effectiveness of these compounds.	Gangliosides	75-87	phospholipase A2 group IIA	Homo sapiens	37-41
10656035-3	1999	Trypanosoma cruzi must invade nucleated cells to survive and reproduce within the mammalian host, and it has been suggested that ganglioside treatment inhibits the parasite"s phospholipase A2 enzymes (PLA2), which are involved in membrane destabilization.	Gangliosides	129-140	phospholipase A2 group IB	Homo sapiens	175-191
10656035-3	1999	Trypanosoma cruzi must invade nucleated cells to survive and reproduce within the mammalian host, and it has been suggested that ganglioside treatment inhibits the parasite"s phospholipase A2 enzymes (PLA2), which are involved in membrane destabilization.	Gangliosides	129-140	phospholipase A2 group IIA	Homo sapiens	201-205
10318836-5	1999	In hematopoietic cells, these low density Triton-insoluble (LDTI) microdomains (also called caveolae-related domains) are dramatically enriched in signaling molecules, such as cell surface receptors (CD4 and CD55), Src family tyrosine kinases (Lyn, Lck, Hck, and Fyn), heterotrimeric G proteins, and gangliosides (GM1 and GM3).	Gangliosides	300-312	CD4 molecule	Homo sapiens	200-203
10389914-2	1999	The present study evaluates immunization using the anti-idiotypic antibody BEC2, which mimics the ganglioside GD3 expressed on the surface of most SCLC tumors, combined with Bacillus Calmette-Guerin (BCG) as an immune adjuvant.	Gangliosides	98-109	potassium voltage-gated channel subfamily H member 4	Homo sapiens	75-79
10389914-2	1999	The present study evaluates immunization using the anti-idiotypic antibody BEC2, which mimics the ganglioside GD3 expressed on the surface of most SCLC tumors, combined with Bacillus Calmette-Guerin (BCG) as an immune adjuvant.	Gangliosides	98-109	GRDX	Homo sapiens	110-113
10318776-0	1999	Attenuation of interleukin 2 signal in the spleen cells of complex ganglioside-lacking mice.	Gangliosides	67-78	interleukin 2	Mus musculus	15-28
10318776-2	1999	GM1, asialo-GM1, and GD1b were representative gangliosides expressed on T cells of the wild type mice and completely deleted on those of the mutant mice.	Gangliosides	46-58	coenzyme Q10A	Mus musculus	0-3
10318776-6	1999	Activation of JAK1, JAK3, and SAT5 after IL-2 treatment was reduced, and c-fos expression was delayed and reduced in the mutant spleen cells, suggesting that the IL-2 signal was attenuated in the mutant mice probably due to the modulation of IL-2 receptors by the lack of complex gangliosides.	Gangliosides	280-292	interleukin 2	Mus musculus	162-166
10318776-6	1999	Activation of JAK1, JAK3, and SAT5 after IL-2 treatment was reduced, and c-fos expression was delayed and reduced in the mutant spleen cells, suggesting that the IL-2 signal was attenuated in the mutant mice probably due to the modulation of IL-2 receptors by the lack of complex gangliosides.	Gangliosides	280-292	interleukin 2	Mus musculus	162-166
10318836-5	1999	In hematopoietic cells, these low density Triton-insoluble (LDTI) microdomains (also called caveolae-related domains) are dramatically enriched in signaling molecules, such as cell surface receptors (CD4 and CD55), Src family tyrosine kinases (Lyn, Lck, Hck, and Fyn), heterotrimeric G proteins, and gangliosides (GM1 and GM3).	Gangliosides	300-312	CD55 molecule (Cromer blood group)	Homo sapiens	208-212
10337924-0	1999	Subclass distribution and the secretory component of serum IgA anti-ganglioside antibodies in Guillain-Barre syndrome after Campylobacter jejuni enteritis.	Gangliosides	68-79	CD79a molecule	Homo sapiens	59-62
10337924-2	1999	However, the mechanism of the induction of IgA anti-ganglioside antibodies is not clear.	Gangliosides	52-63	CD79a molecule	Homo sapiens	43-46
10337924-7	1999	Seventeen (85%) of 20 patients with IgA anti-ganglioside antibodies had serological evidence of C. jejuni infection and/or a history of antecedent diarrhea.	Gangliosides	45-56	CD79a molecule	Homo sapiens	36-39
10337924-10	1999	The induction mechanism of IgA anti-ganglioside antibodies must be clarified by determining whether concentrations of cytokines, which increase the IgA class switch, are elevated in patients with GBS after C. jejuni enteritis.	Gangliosides	36-47	CD79a molecule	Homo sapiens	27-30
10359121-5	1999	They specifically recognize different types of glycolipids, such as gangliosides, sulfatide and galactosylceramide and release IFN-gamma and TNF-alpha.	Gangliosides	68-80	tumor necrosis factor	Homo sapiens	141-150
10359121-6	1999	T cells specific for gangliosides were found to be CD8+, TCR alphabeta+, restricted by the MHC-like CD1b molecule and specific for epitopes residing in the carbohydrate moiety of gangliosides.	Gangliosides	21-33	CD8a molecule	Homo sapiens	51-54
10359121-6	1999	T cells specific for gangliosides were found to be CD8+, TCR alphabeta+, restricted by the MHC-like CD1b molecule and specific for epitopes residing in the carbohydrate moiety of gangliosides.	Gangliosides	21-33	CD1b molecule	Homo sapiens	100-104
10359121-6	1999	T cells specific for gangliosides were found to be CD8+, TCR alphabeta+, restricted by the MHC-like CD1b molecule and specific for epitopes residing in the carbohydrate moiety of gangliosides.	Gangliosides	179-191	CD8a molecule	Homo sapiens	51-54
10367977-2	1999	Six human milk ganglioside compositions were found, which were designated as GM3, GD3, GX1, GX2, GX3 and GX4.	Gangliosides	15-26	GRDX	Homo sapiens	82-85
10092602-0	1999	Expression cloning of mouse cDNA of CMP-NeuAc:Lactosylceramide alpha2,3-sialyltransferase, an enzyme that initiates the synthesis of gangliosides.	Gangliosides	133-145	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	36-89
10207178-5	1999	GM3(Neu5Ac) with C18-sphingosine was the major ganglioside constituting about 90% of the whole ganglioside fraction.	Gangliosides	47-58	Bardet-Biedl syndrome 9	Homo sapiens	17-20
10217254-2	1999	In a search for the genes involved in this ganglioside-induced Neuro2a differentiation, we used a tetracycline-regulated GD3 synthase cDNA expression system combined with differential display PCRs to identify mRNAs that were differentially expressed at four representative time points during the process.	Gangliosides	43-54	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	121-133
10217254-4	1999	These cDNAs were named GDAP1-GDAP10 for (ganglioside-induced differentiation-associated protein) cDNAs.	Gangliosides	41-52	ganglioside-induced differentiation-associated-protein 1	Mus musculus	23-28
10217254-4	1999	These cDNAs were named GDAP1-GDAP10 for (ganglioside-induced differentiation-associated protein) cDNAs.	Gangliosides	41-52	ganglioside-induced differentiation-associated-protein 10	Mus musculus	29-35
10194329-2	1999	To gain insight into the molecular details of this association, we investigated the interactions of Abeta (1-40) with ganglioside-containing membranes by circular dichroism (CD) and Fourier transform infrared-polarized attenuated total reflection (FTIR-PATR) spectroscopy.	Gangliosides	118-129	amyloid beta precursor protein	Homo sapiens	100-105
10194329-3	1999	The CD study revealed that at physiological ionic strength Abeta (1-40) specifically binds to ganglioside-containing membranes inducing a two-state, unordered --> beta-sheet transition above a threshold intramembrane ganglioside concentration, which depends on the host lipid bilayers used.	Gangliosides	94-105	amyloid beta precursor protein	Homo sapiens	59-64
10420586-0	1999	Ganglioside GD1 alpha analogues as high-affinity ligands for myelin-associated glycoprotein (MAG).	Gangliosides	0-11	myelin associated glycoprotein	Homo sapiens	61-91
10194329-3	1999	The CD study revealed that at physiological ionic strength Abeta (1-40) specifically binds to ganglioside-containing membranes inducing a two-state, unordered --> beta-sheet transition above a threshold intramembrane ganglioside concentration, which depends on the host lipid bilayers used.	Gangliosides	220-231	amyloid beta precursor protein	Homo sapiens	59-64
10420586-0	1999	Ganglioside GD1 alpha analogues as high-affinity ligands for myelin-associated glycoprotein (MAG).	Gangliosides	0-11	myelin associated glycoprotein	Homo sapiens	93-96
10194329-6	1999	These results suggest that Abeta (1-40) imposes negative curvature strain on ganglioside-containing lipid bilayers, disturbing the structure and function of the membranes.	Gangliosides	77-88	amyloid beta precursor protein	Homo sapiens	27-32
10208534-0	1999	Enhancement of TNF-alpha production by ganglioside GM2 in human mononuclear cell culture.	Gangliosides	39-50	eiger	Drosophila melanogaster	15-24
10208534-4	1999	We found that ganglioside GM2 markedly enhances the production of TNF-alpha and that TNF-alpha induction by coated GM2 is still more marked.	Gangliosides	14-25	tumor necrosis factor	Homo sapiens	66-75
9950679-0	1999	Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: biochemical characterization and biological consequences in endothelial cell cultures.	Gangliosides	60-72	fibroblast growth factor 2	Homo sapiens	15-41
9930722-5	1999	Notably, it was found that neuroblastoma cell lines with high GD2 ganglioside levels had low levels of GD3, its synthase, and mRNA for the enzyme even though this step provides the substrate for GD2 synthesis.	Gangliosides	66-77	GRDX	Homo sapiens	103-106
10066419-0	1999	Gangliosides GD1a and GM3 induce interleukin-10 production by human T cells.	Gangliosides	0-12	interleukin 10	Homo sapiens	33-47
10066419-2	1999	Gangliosides GD1a and GM3 strongly induced interleukin-10 (IL-10) protein secretion and mRNA expression in T cells from normal human subjects while the other gangliosides were ineffective.	Gangliosides	0-12	interleukin 10	Homo sapiens	43-57
10066419-2	1999	Gangliosides GD1a and GM3 strongly induced interleukin-10 (IL-10) protein secretion and mRNA expression in T cells from normal human subjects while the other gangliosides were ineffective.	Gangliosides	0-12	interleukin 10	Homo sapiens	59-64
10066419-3	1999	IL-10 induction by both gangliosides was completely blocked by protein tyrosine kinase (PTK) inhibitors, herbimycin A, genistein, and tyrphostin AG 1288, but not by other signal transduction inhibitors.	Gangliosides	24-36	interleukin 10	Homo sapiens	0-5
10066419-5	1999	These gangliosides may thus act as important immunoregulators via IL-10.	Gangliosides	6-18	interleukin 10	Homo sapiens	66-71
10190298-0	1999	Occurrence of ganglioside GD3 in neoplastic astrocytes.	Gangliosides	14-25	GRDX	Homo sapiens	26-29
10190298-3	1999	Extraction of the ganglioside fraction from GM was used for thin-layer chromatography (TLC) analysis to confirm the specificity of anti-GD3 monoclonal antibody (DSG-1).	Gangliosides	18-29	GRDX	Homo sapiens	136-139
10190298-3	1999	Extraction of the ganglioside fraction from GM was used for thin-layer chromatography (TLC) analysis to confirm the specificity of anti-GD3 monoclonal antibody (DSG-1).	Gangliosides	18-29	desmoglein 1	Homo sapiens	161-166
10190298-8	1999	In TLC analysis, enzyme immunostaining of gangliosides from GM with DSG-1 showed only one positive band, which had the same TLC migration rate as GD3, indicating that GD3 of the ganglioside fraction from GM is the antigen detected by DSG-1.	Gangliosides	42-54	desmoglein 1	Homo sapiens	68-73
10190298-8	1999	In TLC analysis, enzyme immunostaining of gangliosides from GM with DSG-1 showed only one positive band, which had the same TLC migration rate as GD3, indicating that GD3 of the ganglioside fraction from GM is the antigen detected by DSG-1.	Gangliosides	42-54	GRDX	Homo sapiens	167-170
10190298-8	1999	In TLC analysis, enzyme immunostaining of gangliosides from GM with DSG-1 showed only one positive band, which had the same TLC migration rate as GD3, indicating that GD3 of the ganglioside fraction from GM is the antigen detected by DSG-1.	Gangliosides	42-53	desmoglein 1	Homo sapiens	68-73
10190298-8	1999	In TLC analysis, enzyme immunostaining of gangliosides from GM with DSG-1 showed only one positive band, which had the same TLC migration rate as GD3, indicating that GD3 of the ganglioside fraction from GM is the antigen detected by DSG-1.	Gangliosides	42-53	GRDX	Homo sapiens	167-170
9950679-0	1999	Interaction of fibroblast growth factor-2 (FGF-2) with free gangliosides: biochemical characterization and biological consequences in endothelial cell cultures.	Gangliosides	60-72	fibroblast growth factor 2	Homo sapiens	43-48
9972872-6	1999	The binding of MBP to ganglioside GM1 and the ability of MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1) to compete for the binding of a mitogenic peptide (MBP(1-44)) to SC, identified ganglioside GM1 as a second SC receptor.	Gangliosides	22-33	myelin basic protein	Homo sapiens	15-18
9972868-5	1999	However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release.	Gangliosides	86-98	amyloid beta precursor protein	Homo sapiens	22-28
9972872-6	1999	The binding of MBP to ganglioside GM1 and the ability of MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1) to compete for the binding of a mitogenic peptide (MBP(1-44)) to SC, identified ganglioside GM1 as a second SC receptor.	Gangliosides	137-148	myelin basic protein	Homo sapiens	57-60
9972868-5	1999	However, treatment of A beta-activated THP-1 cells with GM1 and several other complex gangliosides, but not hematosides and neutral glycosphingolipids such as asialo-GM1 (GA1), lactosylceramide, and globoside, significantly decreased the cytokine release.	Gangliosides	86-98	GLI family zinc finger 2	Homo sapiens	39-44
9950679-1	1999	Exogenous gangliosides affect the angiogenic activity of fibroblast growth factor-2 (FGF-2), but their mechanism of action has not been elucidated.	Gangliosides	10-22	fibroblast growth factor 2	Homo sapiens	57-83
9972868-6	1999	In contrast, this effect was not observed for lipopolysaccharide (LPS)-activated and thrombin-activated THP-1 cells, indicating that the ganglioside effect is specific for A beta-induced cytokine release.	Gangliosides	137-148	amyloid beta precursor protein	Homo sapiens	172-178
9972872-6	1999	The binding of MBP to ganglioside GM1 and the ability of MBP peptides containing homology to the B subunit of cholera toxin (which binds ganglioside GM1) to compete for the binding of a mitogenic peptide (MBP(1-44)) to SC, identified ganglioside GM1 as a second SC receptor.	Gangliosides	137-148	myelin basic protein	Homo sapiens	57-60
9972872-7	1999	Based on these results, we conclude that MBP(1-44) and MBP(152-167) associate with ganglioside GM1 and the bFGF receptor respectively to stimulate SC mitosis.	Gangliosides	83-94	myelin basic protein	Homo sapiens	41-44
9972872-7	1999	Based on these results, we conclude that MBP(1-44) and MBP(152-167) associate with ganglioside GM1 and the bFGF receptor respectively to stimulate SC mitosis.	Gangliosides	83-94	myelin basic protein	Homo sapiens	55-58
9950679-1	1999	Exogenous gangliosides affect the angiogenic activity of fibroblast growth factor-2 (FGF-2), but their mechanism of action has not been elucidated.	Gangliosides	10-22	fibroblast growth factor 2	Homo sapiens	85-90
9950679-3	1999	Size exclusion chromatography demonstrates that native, but not heat-denatured, 125I-FGF-2 binds to micelles formed by gangliosides GT1b, GD1b, or GM1.	Gangliosides	119-131	fibroblast growth factor 2	Homo sapiens	85-90
9950679-4	1999	Also, gangliosides protect native FGF-2 from trypsin digestion at micromolar concentrations, the order of relative potency being GT1b > GD1b > GM1 = GM2 = sulfatide > GM3 = galactosyl-ceramide, whereas asialo-GM1, neuraminic acid, and N-acetylneuramin-lactose were ineffective.	Gangliosides	6-18	fibroblast growth factor 2	Homo sapiens	34-39
9950679-7	1999	These data identify the COOH terminus of FGF-2 as a putative ganglioside-binding region.	Gangliosides	61-72	fibroblast growth factor 2	Homo sapiens	41-46
9950679-8	1999	Exogenous gangliosides inhibit the binding of 125I-FGF-2 to high-affinity tyrosine-kinase FGF-receptors (FGFRs) of endothelial GM 7373 cells at micromolar concentrations.	Gangliosides	10-22	fibroblast growth factor 2	Bos taurus	51-56
9950679-12	1999	In agreement with their FGFR antagonist activity, free gangliosides inhibit the mitogenic activity exerted by FGF-2 on endothelial cells in the same range of concentrations.	Gangliosides	55-67	fibroblast growth factor 2	Homo sapiens	110-115
9950679-14	1999	In conclusion, the data demonstrate the capacity of exogenous gangliosides to interact with FGF-2.	Gangliosides	62-74	fibroblast growth factor 2	Homo sapiens	92-97
9950679-15	1999	This interaction involves the COOH terminus of the FGF-2 molecule and depends on the structure of the oligosaccharide chain and on the presence of sialic acid residue(s) in the ganglioside molecule.	Gangliosides	177-188	fibroblast growth factor 2	Homo sapiens	51-56
9950679-16	1999	Exogenous gangliosides act as FGF-2 antagonists when added to endothelial cell cultures.	Gangliosides	10-22	fibroblast growth factor 2	Homo sapiens	30-35
9950679-17	1999	Since gangliosides are extensively shed by tumor cells and reach elevated levels in the serum of tumor-bearing patients, our data suggest that exogenous gangliosides may affect endothelial cell function by a direct interaction with FGF-2, thus modulating tumor neovascularization.	Gangliosides	6-18	fibroblast growth factor 2	Homo sapiens	232-237
9950679-17	1999	Since gangliosides are extensively shed by tumor cells and reach elevated levels in the serum of tumor-bearing patients, our data suggest that exogenous gangliosides may affect endothelial cell function by a direct interaction with FGF-2, thus modulating tumor neovascularization.	Gangliosides	153-165	fibroblast growth factor 2	Homo sapiens	232-237
10201289-0	1999	Demonstration of ganglioside GD3 in human reactive astrocytes.	Gangliosides	17-28	GRDX	Homo sapiens	29-32
10201289-2	1999	Ganglioside GD3 (II3a(NeuAca2-8NeuAc)-LacCer, GD3) in reactive astrocytes from autopsied patients with Creutzfeldt-Jakob disease (CJD) and old cerebral infarction was investigated immunocytochemically, using mouse IgM anti-GD3 monoclonal antibody (DSG-1).	Gangliosides	0-11	GRDX	Homo sapiens	12-15
10201289-2	1999	Ganglioside GD3 (II3a(NeuAca2-8NeuAc)-LacCer, GD3) in reactive astrocytes from autopsied patients with Creutzfeldt-Jakob disease (CJD) and old cerebral infarction was investigated immunocytochemically, using mouse IgM anti-GD3 monoclonal antibody (DSG-1).	Gangliosides	0-11	desmoglein 1	Homo sapiens	248-253
9892679-11	1999	Human tumors overexpress ganglioside GD3 (NeuAcalpha2,8NeuAcalpha2, 3Galbeta1,4Glc-Cer), which in meningiomas correlates with deletions on chromosome 22.	Gangliosides	25-36	GRDX	Homo sapiens	37-40
10405830-3	1999	MDT.1 has reactivity against lipid A, double- and single-stranded DNA, red blood cell associated i antigen, and ganglioside antigens.	Gangliosides	112-123	retinol dehydrogenase 11	Homo sapiens	0-5
9918205-0	1999	Immunization of melanoma patients with BEC2-keyhole limpet hemocyanin plus BCG intradermally followed by intravenous booster immunizations with BEC2 to induce anti-GD3 ganglioside antibodies.	Gangliosides	168-179	potassium voltage-gated channel subfamily H member 4	Homo sapiens	39-43
9918205-0	1999	Immunization of melanoma patients with BEC2-keyhole limpet hemocyanin plus BCG intradermally followed by intravenous booster immunizations with BEC2 to induce anti-GD3 ganglioside antibodies.	Gangliosides	168-179	potassium voltage-gated channel subfamily H member 4	Homo sapiens	144-148
9918205-0	1999	Immunization of melanoma patients with BEC2-keyhole limpet hemocyanin plus BCG intradermally followed by intravenous booster immunizations with BEC2 to induce anti-GD3 ganglioside antibodies.	Gangliosides	168-179	GRDX	Homo sapiens	164-167
9892212-8	1999	These data provided evidence that changes in ganglioside expression in cancer cells by appropriate gene transfection can dramatically affect EGFR kinase activity.	Gangliosides	45-56	epidermal growth factor receptor	Homo sapiens	141-145
10405830-8	1999	The complementarity-determining region 3 (CDR3) of MDT.1 is arginine rich, with five out of 12 residues being arginine and these residues are candidates for interaction with the negatively charged ganglioside.	Gangliosides	197-208	retinol dehydrogenase 11	Homo sapiens	51-56
10405830-9	1999	The ability of MoAb MDT.1 to recognise ganglioside antigens is associated with potentially useful anti-tumour activity.	Gangliosides	39-50	retinol dehydrogenase 11	Homo sapiens	20-25
10512048-1	1999	Influence of serum factors on ganglioside inhibition of IL-4-dependent cell proliferation.	Gangliosides	30-41	interleukin 4	Homo sapiens	56-60
10378147-0	1999	High levels of GM1-ganglioside beta-galactosidase in the salivary glands and GM1-like-ganglioside storage in parotids of deficient mice.	Gangliosides	19-30	coenzyme Q10A	Mus musculus	15-18
10378147-0	1999	High levels of GM1-ganglioside beta-galactosidase in the salivary glands and GM1-like-ganglioside storage in parotids of deficient mice.	Gangliosides	19-30	galactosidase, beta 1	Mus musculus	31-49
10378147-8	1999	Thus, beta-gal activity observed in the parotid gland most likely reflects its role in GM1-ganglioside catabolism, and this ganglioside, never previously reported in the salivary glands, may have a role in parotid exocrine secretory functions.	Gangliosides	91-102	galactosidase, beta 1	Mus musculus	6-14
10378147-8	1999	Thus, beta-gal activity observed in the parotid gland most likely reflects its role in GM1-ganglioside catabolism, and this ganglioside, never previously reported in the salivary glands, may have a role in parotid exocrine secretory functions.	Gangliosides	91-102	coenzyme Q10A	Mus musculus	87-90
10512048-2	1999	Gangliosides have been shown to inhibit proliferation of the interleukin-4 (IL-4) responsive cell line CT.4R.	Gangliosides	0-12	interleukin 4	Homo sapiens	61-74
10512048-2	1999	Gangliosides have been shown to inhibit proliferation of the interleukin-4 (IL-4) responsive cell line CT.4R.	Gangliosides	0-12	interleukin 4	Homo sapiens	76-80
10512048-7	1999	Dissociation constants of the IL-4-ganglioside complexes have been determined; lactosylceramide does not interact with rIL-4.	Gangliosides	35-46	interleukin 4	Homo sapiens	30-34
10512048-8	1999	The K(d) values for the lymphokine complexes with gangliosides support the conclusion based on the kinetic analysis that IL-4 has a higher affinity for GM3 (K(d) = 5 nM) than for GM1 (K(d) = 0.28 microM).	Gangliosides	50-62	interleukin 4	Homo sapiens	121-125
9832129-7	1998	In addition, pertussis toxin inhibited prosaptide-induced neurite outgrowth, as well as prosaptide-enhanced ganglioside concentrations in NS20Y cells, suggesting that prosaposin acted via a G protein-mediated pathway, affecting both ganglioside content and neuronal differentiation.	Gangliosides	108-119	prosaposin	Mus musculus	167-177
10499418-1	1999	We have analyzed sequence homologies between nonimmunogenic phage displayed peptides mimicking GD3 ganglioside and human/mouse self-proteins.	Gangliosides	99-110	GRDX	Homo sapiens	95-98
10499418-2	1999	The GD3 ganglioside phagotopes showed homology to proteins involved in carbohydrate metabolism/transport.	Gangliosides	8-19	GRDX	Homo sapiens	4-7
9857052-4	1998	Scanning confocal microscopy revealed the translocation and clustering on the cell surface of PKC isozymes delta and theta (more evidently than alpha and beta) after GM3 treatment, suggesting the involvement of these isozymes in the ganglioside-induced CD4 down-modulation.	Gangliosides	233-244	protein kinase C delta	Homo sapiens	94-97
9875239-7	1998	The ST3Gal V gene was strongly expressed in mouse brain and liver, which contained a large amount of ganglioside.	Gangliosides	101-112	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	4-12
10102661-4	1998	GD3 and GM3 are the predominant individual gangliosides in bovine milk.	Gangliosides	43-55	GRDX	Homo sapiens	0-3
10102661-10	1998	Since GD3 and other gangliosides have been involved in mechanisms of lymphocyte activation and differentiation, dietary gangliosides might have a function in intestinal immunity development.	Gangliosides	120-132	GRDX	Homo sapiens	6-9
9832129-7	1998	In addition, pertussis toxin inhibited prosaptide-induced neurite outgrowth, as well as prosaptide-enhanced ganglioside concentrations in NS20Y cells, suggesting that prosaposin acted via a G protein-mediated pathway, affecting both ganglioside content and neuronal differentiation.	Gangliosides	233-244	prosaposin	Mus musculus	167-177
9832129-9	1998	We suggest that ganglioside-protein complexes are structural components of the prosaposin receptor involved in cell differentiation.	Gangliosides	16-27	prosaposin	Mus musculus	79-89
9796066-4	1998	LT is composed of an A subunit, carrying the toxic ADP-ribosylation activity, and a pentamer of identical B subunits, which mediates binding to ganglioside GM1, the cellular receptor for the toxin.	Gangliosides	144-155	coenzyme Q10A	Mus musculus	156-159
9874495-1	1998	We have previously shown that a subpopulation of peripheral blood CD4+ T-cells are strongly positive for the ganglioside 9-O-acetyl GD3.	Gangliosides	109-120	GRDX	Homo sapiens	132-135
9799808-5	1998	The TIM gangliosides consisted of over 30 structures as assessed by two-dimensional high performance thin-layer chromatography.	Gangliosides	8-20	translocation induced circling mutation	Mus musculus	4-7
9809988-7	1998	DL-PDMP is a potent inhibitor of glucosylceramide synthase, resulting in inhibition of the synthesis and shedding of gangliosides.	Gangliosides	117-129	UDP-glucose ceramide glucosyltransferase	Mus musculus	33-58
9797137-0	1998	Therapeutic efficacy of mouse-human chimeric anti-ganglioside GM2 monoclonal antibody against multiple organ micrometastases of human lung cancer in NK cell-depleted SCID mice.	Gangliosides	50-61	cytochrome b5 domain containing 2	Mus musculus	62-65
9767101-3	1998	By chemical detection and mass spectrometric analysis of the gangliosides of YAC-1 murine lymphoma cells, we first confirmed that all major ganglioside species are released.	Gangliosides	61-73	ADP-ribosyltransferase 1	Mus musculus	77-82
9748278-9	1998	The present results and our previous observations clearly demonstrate that Trk requires endogenous gangliosides, especially GM1, for its normal function in mediating the neurotrophic activity of NGF at least in PC12 cells.	Gangliosides	99-111	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	75-78
9748278-9	1998	The present results and our previous observations clearly demonstrate that Trk requires endogenous gangliosides, especially GM1, for its normal function in mediating the neurotrophic activity of NGF at least in PC12 cells.	Gangliosides	99-111	nerve growth factor	Rattus norvegicus	195-198
9767101-3	1998	By chemical detection and mass spectrometric analysis of the gangliosides of YAC-1 murine lymphoma cells, we first confirmed that all major ganglioside species are released.	Gangliosides	61-72	ADP-ribosyltransferase 1	Mus musculus	77-82
9767101-6	1998	Although the ganglioside concentration in the conditioned medium (6-14x10-8 M) was above the critical micelle concentration of purified YAC-1 gangliosides (<1x10-8 M), by gel filtration >90% of the soluble gangliosides were found in monomeric form (MW <2 kDa) and only <10% in micelles (130 kDa).	Gangliosides	142-154	ADP-ribosyltransferase 1	Mus musculus	136-141
9766735-2	1998	The aim of this study was to provide data on the concentration of gangliosides in the CSF of children and adolescents with autism spectrum disorders (ASD) - 66 with autistic disorder, and 19 with other autism spectrum disorders.	Gangliosides	66-78	colony stimulating factor 2	Homo sapiens	86-89
9705944-2	1998	To provide costimulation to T lymphocytes that recognize tumor cells, we constructed a CD28-like receptor specific for GD2, a ganglioside overexpressed on the surface of neuroblastoma, small-cell lung carcinoma, melanoma, and other human tumors.	Gangliosides	126-137	CD28 molecule	Homo sapiens	87-91
9721722-9	1998	This assumption was corroborated by metabolic labeling studies with radioactive ganglioside precursors indicating an enhancement of the relative amount of a-series gangliosides subsequent to GM3 on phosphorylation stimulation.	Gangliosides	80-91	granulocyte macrophage antigen 3	Mus musculus	191-194
9728335-6	1998	Three polypeptide chains contribute to the in vivo degradation of ganglioside GM2: the alpha- and beta-chains of the beta-hexosaminidases and the GM2 activator.	Gangliosides	66-77	cytochrome b5 domain containing 2	Mus musculus	78-81
9718122-0	1998	Increased cerebrospinal fluid ganglioside GD3 concentrations as a marker of microglial activation in HIV type 1 infection.	Gangliosides	30-41	GRDX	Homo sapiens	42-45
9694901-8	1998	Biochemical characterization of Hex A from both patient cells and cotransfected CHO cells demonstrated that this substitution (a) decreases the level of heterodimer transport out of the endoplasmic reticulum by approximately 45%, (b) lowers its heat stability, (c) does not affect its Km for neutral or charged artificial substrates, and (d) lowers the ratio of units of ganglioside/units of artificial substrate hydrolyzed by a factor of 3.	Gangliosides	371-382	hexosaminidase subunit alpha	Homo sapiens	32-37
9728335-6	1998	Three polypeptide chains contribute to the in vivo degradation of ganglioside GM2: the alpha- and beta-chains of the beta-hexosaminidases and the GM2 activator.	Gangliosides	66-77	cytochrome b5 domain containing 2	Mus musculus	146-149
9682399-3	1998	The plant-derived LT-B assembled into native pentameric structures as evidenced by its ability to bind ganglioside.	Gangliosides	103-114	lymphotoxin B	Mus musculus	18-22
9761454-0	1998	A new procedure for determining ganglioside GD3 a potential glial cell activation marker in cerebrospinal fluid.	Gangliosides	32-43	GRDX	Homo sapiens	44-47
9761454-1	1998	Increased amounts of ganglioside GD3 [II3 (NeuAc)2-LacCer], associated with reactive gliosis, have been documented in a variety of neurodegenerative disorders.	Gangliosides	21-32	GRDX	Homo sapiens	33-36
9761454-8	1998	GD3 ganglioside analysis by means of this method might be useful for studying glial changes during brain maturation as well as in brain disorders.	Gangliosides	4-15	GRDX	Homo sapiens	0-3
9670840-3	1998	Gangliosides inhibited EL4 cell growth by causing progressive cell cycle arrest.	Gangliosides	0-12	epilepsy 4	Mus musculus	23-26
9682003-1	1998	The involvement of protein kinases and phosphatases in the down-modulation of expression of CD4 molecules on peripheral blood lymphocytes (PBL) by gangliosides was studied.	Gangliosides	147-159	CD4 molecule	Homo sapiens	92-95
9644263-0	1998	Antibody against ganglioside GD1c containing NeuGcalpha2-8NeuGc cooperates with CD3 and CD4 in rat T cell activation.	Gangliosides	17-28	Cd4 molecule	Rattus norvegicus	88-91
9677390-1	1998	The dramatic changes in the expression of GD3 and other b-series gangliosides during neuronal development and morphogenesis have led to a widely held belief that these gangliosides may be necessary for neuronal differentiation.	Gangliosides	168-180	GRDX	Homo sapiens	42-45
9712367-7	1998	Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels.	Gangliosides	10-22	indoleamine 2,3-dioxygenase 1	Homo sapiens	78-81
9712367-7	1998	Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels.	Gangliosides	10-22	interferon gamma	Bos taurus	125-134
9712367-7	1998	Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels.	Gangliosides	37-49	indoleamine 2,3-dioxygenase 1	Homo sapiens	78-81
9712367-7	1998	Exogenous gangliosides (bovine brain gangliosides and purified GM1) inhibited IDO expression throughout the first 24 h after IFN-gamma treatment by mechanisms that did not involve effects on Ca2+ channels.	Gangliosides	37-49	interferon gamma	Bos taurus	125-134
9629854-7	1998	Secondary ion mass spectrometry showed that the ganglioside"s structure was consistent with that of GM1(NeuGc).	Gangliosides	48-59	coenzyme Q10A	Mus musculus	100-110
9668343-7	1998	GM3 inhibits both the epidermal growth factor receptor and basic fibroblast factor receptor; several gangliosides except GM3 inhibit the platelet-derived growth-factor receptor; GM1 enhances nerve growth-factor-stimulated activation of TrkA; insulin receptor is inhibited to varying degrees by several gangliosides, but 2-->3 sialosylparagloboside is most effective.	Gangliosides	302-314	neurotrophic receptor tyrosine kinase 1	Homo sapiens	236-240
9668345-0	1998	Myelin-associated glycoprotein binding to gangliosides.	Gangliosides	42-54	myelin associated glycoprotein	Homo sapiens	0-30
9668345-3	1998	Gangliosides, the most abundant sialylated glycoconjugates in the brain, may be the functional neuronal ligands for MAG.	Gangliosides	0-12	myelin associated glycoprotein	Homo sapiens	116-119
9668345-4	1998	Cells engineered to express MAG on their surface adhered specifically to gangliosides bearing an alpha 2,3-linked N-acetylneuraminic acid on a terminal galactose, with the following relative potency: GQ1b alpha >> GD1a, GT1b >> GM3, GM4 (GM1, GD1b, GD3, and GQ1b did not support adhesion).	Gangliosides	73-85	myelin associated glycoprotein	Homo sapiens	28-31
9668345-5	1998	MAG binding was abrogated by modification of the carboxylic acid, any hydroxyl, or the N-acetyl group of the ganglioside"s N-acetylneuraminic acid moiety.	Gangliosides	109-120	myelin associated glycoprotein	Homo sapiens	0-3
9668345-8	1998	These data are consistent with a role for gangliosides in MAG-neuron interactions.	Gangliosides	42-54	myelin associated glycoprotein	Homo sapiens	58-61
9668358-4	1998	Several growth factors [e.g., basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF)] and one species of ganglioside (GM1) have been shown to exert interactions with each other and also to exhibit neuroprotective effects against retinal ischemia in vivo and cerebral excitotoxicity in vitro.	Gangliosides	122-133	epidermal growth factor like 1	Rattus norvegicus	97-100
9668362-4	1998	Evidence is presented in support of the hypotheses that (1) serum albumin functions in the transport of gangliosides across the blood-brain barrier, and (2) when gangliosides inhibit cell proliferation, they do so by inhibiting the activity of DNA polymerases alpha and beta.	Gangliosides	162-174	DNA polymerase alpha 1, catalytic subunit	Homo sapiens	244-265
9629854-9	1998	N-Glycolylneuraminic acid-containing gangliosides are so highly immunogenic in humans that the injection of GM1(NeuGc) could induce the production of IgG anti-GM1(NeuGc) antibody, which cross-reacts with GM1(NeuAc).	Gangliosides	37-49	coenzyme Q10A	Mus musculus	108-118
9629854-9	1998	N-Glycolylneuraminic acid-containing gangliosides are so highly immunogenic in humans that the injection of GM1(NeuGc) could induce the production of IgG anti-GM1(NeuGc) antibody, which cross-reacts with GM1(NeuAc).	Gangliosides	37-49	coenzyme Q10A	Mus musculus	159-169
9657909-5	1998	Cells cultured on vitronectin expressed sialyl-Lewisx gangliosides and did not exhibit GD3.	Gangliosides	54-66	vitronectin	Macaca mulatta	18-29
9592126-2	1998	It has been shown that when gangliosides are added to the culture medium of PC12 cells, NGF-induced neurite formation of PC12 cells is enhanced.	Gangliosides	28-40	nerve growth factor	Rattus norvegicus	88-91
9592126-8	1998	These findings, together with previous studies showing enhancement of NGF-induced neurite formation by exogenous gangliosides, underscore the vastly different effects that exogenous gangliosides and endogenous gangliosides may have upon cellular functions.	Gangliosides	113-125	nerve growth factor	Rattus norvegicus	70-73
9592126-8	1998	These findings, together with previous studies showing enhancement of NGF-induced neurite formation by exogenous gangliosides, underscore the vastly different effects that exogenous gangliosides and endogenous gangliosides may have upon cellular functions.	Gangliosides	182-194	nerve growth factor	Rattus norvegicus	70-73
9592126-8	1998	These findings, together with previous studies showing enhancement of NGF-induced neurite formation by exogenous gangliosides, underscore the vastly different effects that exogenous gangliosides and endogenous gangliosides may have upon cellular functions.	Gangliosides	182-194	nerve growth factor	Rattus norvegicus	70-73
9592190-1	1998	3F8 is an IgG3 murine monoclonal antibody directed against the ganglioside GD2.	Gangliosides	63-74	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	10-14
9706484-0	1998	Induction of nitric oxide production by ganglioside GM3 in murine peritoneal macrophages activated for tumor cytotoxicity.	Gangliosides	40-51	granulocyte macrophage antigen 3	Mus musculus	52-55
9582303-5	1998	Another gene represented a UDP-galactose:beta-N-acetyl-galactosamine beta-1, 3-galactosyltransferase (beta3Gal-T4) involved in GM1/GD1 ganglioside synthesis, and this gene was highly similar to a recently reported rat GD1 synthase (Miyazaki, H., Fukumoto, S., Okada, M., Hasegawa, T., and Furukawa, K. (1997) J. Biol.	Gangliosides	135-146	Beta-1,3-galactosyltransferase 4	Rattus norvegicus	27-100
9582303-5	1998	Another gene represented a UDP-galactose:beta-N-acetyl-galactosamine beta-1, 3-galactosyltransferase (beta3Gal-T4) involved in GM1/GD1 ganglioside synthesis, and this gene was highly similar to a recently reported rat GD1 synthase (Miyazaki, H., Fukumoto, S., Okada, M., Hasegawa, T., and Furukawa, K. (1997) J. Biol.	Gangliosides	135-146	Beta-1,3-galactosyltransferase 4	Rattus norvegicus	102-113
9600078-2	1998	Recently, we reported that the V3 loop of HIV-1 gp120 binds to GM3, a ganglioside abundantly expressed on CD4+ lymphocytes and macrophages.	Gangliosides	70-81	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	48-53
9600078-2	1998	Recently, we reported that the V3 loop of HIV-1 gp120 binds to GM3, a ganglioside abundantly expressed on CD4+ lymphocytes and macrophages.	Gangliosides	70-81	CD4 molecule	Homo sapiens	106-109
9572850-2	1998	Solid-phase assays and affinity chromatography on immobilized glycolipids indicated that vitronectin purified under denaturing conditions bound to sulfatide (Gal(3-SO4)beta1-1ceramide), cholesterol 3-sulfate, and various phospholipids, but not gangliosides.	Gangliosides	244-256	vitronectin	Homo sapiens	89-100
9706484-1	1998	BACKGROUND: Recently, it was found that ganglioside GM3, known as a potent monocytic cell differentiation inducer, mimicked bacterial lipopolysaccharide (LPS) in the activation of macrophage-mediated tumor cytotoxicity (MTC).	Gangliosides	40-51	granulocyte macrophage antigen 3	Mus musculus	52-55
9706484-3	1998	MATERIALS RESULTS, CONCLUSIONS: Ganglioside GM3 was highly purified from canine erythrocytes by the authors.	Gangliosides	32-43	granulocyte macrophage antigen 3	Mus musculus	44-47
9706484-6	1998	These results demonstrated for the first time that ganglioside GM3 in vitro induces the production of nitric oxide by macrophages, and the GM3-induced MTC is NO-dependent.	Gangliosides	51-62	granulocyte macrophage antigen 3	Mus musculus	63-66
9706484-6	1998	These results demonstrated for the first time that ganglioside GM3 in vitro induces the production of nitric oxide by macrophages, and the GM3-induced MTC is NO-dependent.	Gangliosides	51-62	granulocyte macrophage antigen 3	Mus musculus	139-142
9535903-1	1998	Mouse melanoma B16 cells are characterized by the predominant presence of ganglioside GM3 and adhere to lactosylceramide- or Gg3-coated plates through interaction of GM3 with lactosylceramide or Gg3, whereby not only adhesion but also spreading and enhancement of cell motility occur (Kojima, N., Hakomori, S. (1991) J. Biol.	Gangliosides	74-85	granulocyte macrophage antigen 3	Mus musculus	86-89
9556610-0	1998	Galectin-1 is a major receptor for ganglioside GM1, a product of the growth-controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture.	Gangliosides	35-46	galectin 1	Homo sapiens	0-10
9529046-1	1998	Heat-labile enterotoxin subunit B (LTB) is a noncatalytic protein derived from Escherichia coli that binds to ganglioside GM1, a glycosphingolipid on the surface of mammalian cells.	Gangliosides	110-121	lymphotoxin B	Mus musculus	35-38
9578490-11	1998	We propose that glycoproteins as well as gangliosides carrying sialosyl Le(a) structures, when properly exposed and present in high density on surface of cancer cells, can effectively support the adhesion of cancer cells to E-selectin.	Gangliosides	41-53	selectin E	Homo sapiens	224-234
9529046-10	1998	Apoptosis peaked at around 8 h after exposure to rLTB and incubation at 37 degrees C. Binding to ganglioside GM1 was essential for suppression, since rLTB/G33D, a mutant which does not bind GM1, failed to inhibit proliferation or induce apoptosis.	Gangliosides	97-108	lymphotoxin beta	Rattus norvegicus	49-53
9781285-5	1998	We determined the levels of sphingomyelin ceramide and ganglioside GD3 in Hu197 cells after treatment with cholecalciferol.	Gangliosides	55-66	GRDX	Homo sapiens	67-70
9572057-1	1998	The GM2 gangliosidoses are a group of heritable neurodegenerative disorders caused by excessive accumulation of the ganglioside GM2 owing to deficiency in beta-hexosaminidase activity.	Gangliosides	116-127	O-GlcNAcase	Homo sapiens	155-174
9540820-0	1998	Ganglioside composition of GH3 cells: enhancement of fucoganglioside expression by estradiol, epidermal growth factor and insulin.	Gangliosides	0-11	epidermal growth factor like 1	Rattus norvegicus	94-117
9541741-0	1998	Ganglioside GM1 alters neuronal morphology by modulating the association of MAP2 with microtubules and actin filaments.	Gangliosides	0-11	coenzyme Q10A	Mus musculus	12-15
9541741-0	1998	Ganglioside GM1 alters neuronal morphology by modulating the association of MAP2 with microtubules and actin filaments.	Gangliosides	0-11	microtubule-associated protein 2	Mus musculus	76-80
9541741-1	1998	In previous studies, we demonstrated that the exogenous ganglioside GM1 increased the complexity of the microtubular network and level of tubulin, selectively changed the distribution of microtubule associated protein-2 (MAP2) immunoreactivity from the perikarya to distal neuritic processes and increased immunogold label of MAP2 in the subplasmalemmal cytoplasm, neuritic filopodia and growth cones of Neuro-2a neuroblastoma cells.	Gangliosides	56-67	coenzyme Q10A	Mus musculus	68-71
9541741-1	1998	In previous studies, we demonstrated that the exogenous ganglioside GM1 increased the complexity of the microtubular network and level of tubulin, selectively changed the distribution of microtubule associated protein-2 (MAP2) immunoreactivity from the perikarya to distal neuritic processes and increased immunogold label of MAP2 in the subplasmalemmal cytoplasm, neuritic filopodia and growth cones of Neuro-2a neuroblastoma cells.	Gangliosides	56-67	microtubule-associated protein 2	Mus musculus	187-219
9541741-1	1998	In previous studies, we demonstrated that the exogenous ganglioside GM1 increased the complexity of the microtubular network and level of tubulin, selectively changed the distribution of microtubule associated protein-2 (MAP2) immunoreactivity from the perikarya to distal neuritic processes and increased immunogold label of MAP2 in the subplasmalemmal cytoplasm, neuritic filopodia and growth cones of Neuro-2a neuroblastoma cells.	Gangliosides	56-67	microtubule-associated protein 2	Mus musculus	221-225
9541741-1	1998	In previous studies, we demonstrated that the exogenous ganglioside GM1 increased the complexity of the microtubular network and level of tubulin, selectively changed the distribution of microtubule associated protein-2 (MAP2) immunoreactivity from the perikarya to distal neuritic processes and increased immunogold label of MAP2 in the subplasmalemmal cytoplasm, neuritic filopodia and growth cones of Neuro-2a neuroblastoma cells.	Gangliosides	56-67	microtubule-associated protein 2	Mus musculus	326-330
9541741-2	1998	Since these areas are rich in actin filaments, our data suggested that MAP2 may be associated with microfilaments in the early stages of ganglioside-induced neuritogenesis.	Gangliosides	137-148	microtubule-associated protein 2	Mus musculus	71-75
9541741-6	1998	Our present results suggest that gangliosides enhance neuritogenesis by redistributing actin as well as MAP2 to processes and filopodia thereby facilitating their interaction.	Gangliosides	33-45	microtubule-associated protein 2	Mus musculus	104-108
9541741-7	1998	The association of MAP2 with actin filaments is likely to be an early step in ganglioside-mediated filopodia formation.	Gangliosides	78-89	microtubule-associated protein 2	Mus musculus	19-23
9606992-2	1998	Our previous observation of dramatic premature thymic involution in cats with feline GM1 gangliosidosis, whose thymocytes have abnormally high cell surface gangliosides, suggested that excess GM1 ganglioside (GM1) could modulate thymocyte apoptosis in this disease (Cox et al., "Thymic Alterations in Feline GM1 Gangliosidosis," submitted).	Gangliosides	156-168	coenzyme Q10A	Mus musculus	192-195
9606992-2	1998	Our previous observation of dramatic premature thymic involution in cats with feline GM1 gangliosidosis, whose thymocytes have abnormally high cell surface gangliosides, suggested that excess GM1 ganglioside (GM1) could modulate thymocyte apoptosis in this disease (Cox et al., "Thymic Alterations in Feline GM1 Gangliosidosis," submitted).	Gangliosides	156-168	coenzyme Q10A	Mus musculus	192-195
9543315-5	1998	This IgM M-protein has a unique, previously unreported binding specificity for terminal NeuAcalpha2-3Galbeta- moiety in common to all gangliosides bound by the antibody except GM2.	Gangliosides	134-146	myomesin 2	Homo sapiens	9-18
9821869-0	1998	Human fibroblasts in culture metabolize differently exogenous G(M3) ganglioside species containing C18 and C20 sphingosine.	Gangliosides	68-79	Bardet-Biedl syndrome 9	Homo sapiens	99-102
9821871-1	1998	To detect HL-60 human promyelocytic leukemia cell proteins involved in the uptake of gangliosides from the culture medium we used photoreactive, 4-azidosalicylic acid (ASA) acylated and radioiodinated (200 Ci/mmole) derivatives of GM3, GD3, GM1, and FucGM1 gangliosides.	Gangliosides	85-97	GRDX	Homo sapiens	236-239
9821871-4	1998	The proportion of cell bound gangliosides-ASA resistant to BSA treatment increased with time of incubation up to 76% after 20 h. As shown on TLC, GM3- and GD3-ASA were catabolized to LacSph-ASA and ceramide-ASA, while GM1-ASA was hydrolyzed to GM2-ASA.	Gangliosides	29-41	GRDX	Homo sapiens	155-158
9821877-2	1998	Spontaneous synchronized oscillatory activity of intracellular Ca2+ between the neurons, which represents synapse formation, was suppressed by the depletion of endogenous gangliosides by D-threo-PDMP, an inhibitor of glucosylceramide synthase.	Gangliosides	171-183	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	217-242
9568910-1	1998	Lysosomal degradation of ganglioside GM2 by hexosaminidase A requires the presence of a small, non-enzymatic cofactor, the GM2-activator protein (GM2AP).	Gangliosides	25-36	ganglioside GM2 activator	Homo sapiens	123-144
9568910-1	1998	Lysosomal degradation of ganglioside GM2 by hexosaminidase A requires the presence of a small, non-enzymatic cofactor, the GM2-activator protein (GM2AP).	Gangliosides	25-36	ganglioside GM2 activator	Homo sapiens	146-151
9500792-0	1998	Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells.	Gangliosides	63-74	sphingomyelin phosphodiesterase 1	Homo sapiens	25-28
9500792-0	1998	Acidic sphingomyelinase (ASM) is necessary for fas-induced GD3 ganglioside accumulation and efficient apoptosis of lymphoid cells.	Gangliosides	63-74	GRDX	Homo sapiens	59-62
9538230-7	1998	The polymer binding was inhibited by various gangliosides, the order of the inhibitory potencies being GM3 (IC50 = 40 microM) > GD1a (100 microM) > sialylparagloboside (120 microM) > GT1b (310 microM) > GM2 (640 microM) > GM4 (2,100 microM) > GD1b>LacCer = GM1 = paragloboside (no inhibition).	Gangliosides	45-57	cytochrome b5 domain containing 2	Mus musculus	215-218
9538230-7	1998	The polymer binding was inhibited by various gangliosides, the order of the inhibitory potencies being GM3 (IC50 = 40 microM) > GD1a (100 microM) > sialylparagloboside (120 microM) > GT1b (310 microM) > GM2 (640 microM) > GM4 (2,100 microM) > GD1b>LacCer = GM1 = paragloboside (no inhibition).	Gangliosides	45-57	T cell receptor alpha variable 6-3	Mus musculus	237-240
9451030-3	1998	Two groups have recently isolated cDNAs possibly encoding this enzyme, by expression cloning of human melanoma libraries in COS cells expressing the substrate ganglioside GD3.	Gangliosides	159-170	GRDX	Homo sapiens	171-174
9543315-1	1998	We report the occurrence of a relapsing, severe predominantly motor neuropathy in a 75-year-old man with an IGM-K M-protein binding to gangliosides GM2, GM3, GM4, GD1a, GT1b and LM1.	Gangliosides	135-147	myomesin 2	Homo sapiens	114-123
9821865-7	1998	The activity toward gangliosides, on the other hand, varied independently of metastatic potential: B16-F10 cells with a high potential for experimental metastasis showed the lowest level and B16-BL6 cells having high invasiveness had rather a higher level of ganglioside sialidase along with a much greater GM3 synthase activity than the other two cell lines.	Gangliosides	20-32	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	307-319
9821865-7	1998	The activity toward gangliosides, on the other hand, varied independently of metastatic potential: B16-F10 cells with a high potential for experimental metastasis showed the lowest level and B16-BL6 cells having high invasiveness had rather a higher level of ganglioside sialidase along with a much greater GM3 synthase activity than the other two cell lines.	Gangliosides	20-31	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	307-319
9641502-1	1998	The aim of the study was to evaluate in a double-blind manner the effect of the long-acting 5-hydroxytryptamine 2 (5-HT2)-receptor blocker Ritanserin on clinical symptoms in patients with fibromyalgia syndrome (FM) and on production of antibodies to serotonin, gangliosides and phospholipids, recently shown to have a high incidence in this disease.	Gangliosides	261-273	5-hydroxytryptamine receptor 2A	Homo sapiens	115-130
9393780-6	1997	These data indicate that the toxicity, immunogenicity, and oral adjuvanticity of LT are dependent upon binding of the B subunit to ganglioside GM1.	Gangliosides	131-142	coenzyme Q10A	Mus musculus	143-146
10822616-1	1998	The interactions between the protein, cholera toxin B subunit attached to an atomic force microscope, AFM, cantilever, CTB and its receptor the ganglioside, GM1 have been measured in a dilute electrolyte solution, pH 5.5.	Gangliosides	144-155	chitobiase	Homo sapiens	119-122
9425271-1	1997	We have studied ganglioside alterations and their enzymatic basis during the course of neural differentiation of mouse embryonic carcinoma cell line P19.	Gangliosides	16-27	interleukin 23, alpha subunit p19	Mus musculus	149-152
9425271-9	1997	These results show that RA but not DMSO induces the expression of GM3, GD3, GT1b and GQ1b synthases, and particularly GD3 synthase mRNA, in the ganglioside biosynthetic pathway during the neural differentiation of embryonic carcinoma P19 cells.	Gangliosides	144-155	granulocyte macrophage antigen 3	Mus musculus	66-69
9425271-9	1997	These results show that RA but not DMSO induces the expression of GM3, GD3, GT1b and GQ1b synthases, and particularly GD3 synthase mRNA, in the ganglioside biosynthetic pathway during the neural differentiation of embryonic carcinoma P19 cells.	Gangliosides	144-155	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	118-130
9426962-9	1997	Regardless of the source, GalNAcT in the vitreous humor has the potential to function as a lectin by binding to gangliosides GD3 and GM3 on the surface of retinal cells and, thereby, to influence neuronal development.	Gangliosides	112-124	Polypeptide N-acetylgalactosaminyltransferase 35A	Drosophila melanogaster	26-33
9501410-3	1998	The antigens of the Sia-l1, -b1, -lb1 complex are gangliosides that may carry alpha 2,3NeuNAc (to galactose) and/or alpha 2,8NeuNAc (to NeuNAc).	Gangliosides	50-62	neuraminidase 1	Homo sapiens	20-37
9455911-10	1997	Gangliotetraose-type gangliosides G(M1) and G(D1a) (<1 % of total resorcinol stain) as well as traces of G(D1b) and G(T1b) have been distinctly identified by combined choleragenoid-TLC-immunostaining and previous neuraminidase treatment.	Gangliosides	21-33	neuraminidase 1	Bos taurus	216-229
9455912-5	1997	Gangliosides in the transgenic skin were dramatically converted from GM3 to GM1, whereas no morphological changes were observed.	Gangliosides	0-12	granulocyte macrophage antigen 3	Mus musculus	69-72
9368072-0	1997	Association of Src family tyrosine kinase Lyn with ganglioside GD3 in rat brain.	Gangliosides	51-62	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	15-18
9570388-0	1997	Detection of medulloblastoma and astrocytoma-associated ganglioside GD3 in cerebrospinal fluid.	Gangliosides	56-67	GRDX	Homo sapiens	68-71
9570388-3	1997	GD3, a major ganglioside in medulloblastoma and astrocytoma, was the target for detection in the CSF by immunostaining using the monoclonal antibody R24 and enhanced chemiluminescence detection.	Gangliosides	13-24	GRDX	Homo sapiens	0-3
9570388-6	1997	The elevated CSF GD3 concentrations in patients with medulloblastoma and astrocytoma support the concept that ganglioside shedding, which may have significant biological consequences, is characteristic of human brain tumors.	Gangliosides	110-121	GRDX	Homo sapiens	17-20
9368072-0	1997	Association of Src family tyrosine kinase Lyn with ganglioside GD3 in rat brain.	Gangliosides	51-62	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	42-45
9368072-3	1997	Protein kinase activity was detected in precipitates with monoclonal antibody to ganglioside GD3 (R24) from membranal fraction of rat brain.	Gangliosides	81-92	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	0-14
9368072-6	1997	The identification was confirmed using a cDNA expression system in Chinese hamster ovary (CHO) cells, which express solely ganglioside GM3, the enzymatic substrate of GD3 synthase.	Gangliosides	123-134	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	167-179
9347079-8	1997	Ganglioside GM1, in part, may exert its neuroprotective effects by modulating arachidonyl-specific PLA2 activity in chronic EtOH-exposed neuroblastoma cells.	Gangliosides	0-11	phospholipase A2 group IB	Homo sapiens	99-103
9428343-2	1997	In addition, there is evidence that simple gangliosides such as GD3 are transiently present on the surface of such migratory cells.	Gangliosides	43-55	GRDX	Homo sapiens	64-67
9403993-2	1997	Capitalizing on the readily available ganglioside, GM1, we have devised a simple synthesis of labeled GM1 analogues with sulfur in place of oxygen in their linkage to the ceramide residue (SGM1).	Gangliosides	38-49	growth differentiation factor 6	Homo sapiens	189-193
9450321-0	1997	Ganglioside GD3 and GD3-lactone mediated regulation of the intermolecular organization in mixed monolayers with dipalmitoylphosphatidylcholine.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
9223328-4	1997	For degradation of GM2 ganglioside by beta-hexosamindase A, the GM2 activator protein must participate by forming a soluble complex with the ganglioside.	Gangliosides	23-34	cytochrome b5 domain containing 2	Mus musculus	19-22
9358541-1	1997	PURPOSE: To determine whether the non-toxic pentameric B subunit of Cholera toxin (CTB) binding to ganglioside GM1 on both the lipid vesicles and epithelial cells may provide a means to target lipid vesicles to mucosal cells expressing surface GM1.	Gangliosides	99-110	phosphate cytidylyltransferase 1B, choline	Homo sapiens	83-86
9287216-2	1997	Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation.	Gangliosides	130-141	Fas cell surface death receptor	Homo sapiens	40-44
9287216-2	1997	Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation.	Gangliosides	130-141	Fas cell surface death receptor	Homo sapiens	73-78
9287216-2	1997	Cross-linking of the apoptosis-inducing CD95 protein (also called Fas or APO-1) in lymphoid and myeloid tumor cells triggered GD3 ganglioside synthesis and transient accumulation.	Gangliosides	130-141	GRDX	Homo sapiens	126-129
9337086-5	1997	Biochemical analysis revealed a marked accumulation of ganglioside GM1 and asialo GM1 in brain tissue.	Gangliosides	55-66	coenzyme Q10A	Mus musculus	67-70
9323557-1	1997	Mucolipidosis type IV (MLIV) is a lysosomal storage disorder in which various phospholipids and gangliosides accumulate.	Gangliosides	96-108	mucolipin TRP cation channel 1	Homo sapiens	23-27
9323557-9	1997	The data indicate that PC as well as other phospholipids and gangliosides accumulate in MLIV apparently owing to a defect in the endocytosis process of membranous components.	Gangliosides	61-73	mucolipin TRP cation channel 1	Homo sapiens	88-92
9328574-9	1997	The addition of recombinant interleukin 2 (IL-2) enhanced weak antibody responses to 9-O-acetyl-GD3 thereby facilitating responses to ganglioside in micelles and in protein-free Very Low Density Particles.	Gangliosides	134-145	interleukin 2	Mus musculus	28-41
9328574-9	1997	The addition of recombinant interleukin 2 (IL-2) enhanced weak antibody responses to 9-O-acetyl-GD3 thereby facilitating responses to ganglioside in micelles and in protein-free Very Low Density Particles.	Gangliosides	134-145	interleukin 2	Mus musculus	43-47
9328574-12	1997	VLDL or similar particles and recombinant IL-2 may be useful adjuvants for immunization with gangliosides.	Gangliosides	93-105	interleukin 2	Mus musculus	42-46
9223328-4	1997	For degradation of GM2 ganglioside by beta-hexosamindase A, the GM2 activator protein must participate by forming a soluble complex with the ganglioside.	Gangliosides	23-34	cytochrome b5 domain containing 2	Mus musculus	64-67
9223328-11	1997	The abnormal ganglioside storage in the Gm2a -/- mice consisted of GM2 with a low amount of GA2.	Gangliosides	13-24	cytochrome b5 domain containing 2	Mus musculus	67-70
9191258-0	1997	Ganglioside GM1 potentiates the effect of IL-1 beta on neutral sphingomyelinase activity in rat brain synaptosomes.	Gangliosides	0-11	interleukin 1 beta	Rattus norvegicus	42-51
9201997-5	1997	In contrast, sialoadhesin had less exacting specificity, binding to gangliosides that bear either terminal alpha2,3- or alpha2,8-linked sialic acids with the following rank-order potency of binding: GQ1balpha > GD1a = GD1b = GT1b = GM3 = GM4 > GD3 = GQ1b >> GM1 (nonbinder).	Gangliosides	68-80	sialic acid binding Ig like lectin 1	Homo sapiens	13-25
9201997-7	1997	Binding of MAG, SMP, and sialoadhesin was abrogated by chemical modification of either the sialic acid carboxylic acid group or glycerol side chain on a target ganglioside.	Gangliosides	160-171	myelin associated glycoprotein	Homo sapiens	11-14
9201997-7	1997	Binding of MAG, SMP, and sialoadhesin was abrogated by chemical modification of either the sialic acid carboxylic acid group or glycerol side chain on a target ganglioside.	Gangliosides	160-171	sialic acid binding Ig like lectin 1	Homo sapiens	25-37
9202301-0	1997	Ganglioside GM1 activates the mitogen-activated protein kinase Erk2 and p70 S6 kinase in U-1242 MG human glioma cells.	Gangliosides	0-11	mitogen-activated protein kinase 1	Homo sapiens	63-67
9202301-0	1997	Ganglioside GM1 activates the mitogen-activated protein kinase Erk2 and p70 S6 kinase in U-1242 MG human glioma cells.	Gangliosides	0-11	ribosomal protein S6 kinase B1	Homo sapiens	72-85
9143118-4	1997	When YF-2 was cultured in a synthetic medium containing crude bovine brain gangliosides at 25 degrees C for 3 days, 80 to 90% of the gangliosides were converted to GM1.	Gangliosides	75-87	coenzyme Q10A	Mus musculus	164-167
9143118-4	1997	When YF-2 was cultured in a synthetic medium containing crude bovine brain gangliosides at 25 degrees C for 3 days, 80 to 90% of the gangliosides were converted to GM1.	Gangliosides	133-145	coenzyme Q10A	Mus musculus	164-167
9143118-6	1997	In a typical experiment, 178 mg of highly purified GM1 was obtained from 500 mg of the crude ganglioside fraction.	Gangliosides	93-104	coenzyme Q10A	Mus musculus	51-54
9143348-12	1997	Gangliosides, which specifically form complexes with prosaposin and saposins, inhibit proteolysis of prosaposin by cathepsin D.	Gangliosides	0-12	cathepsin D	Homo sapiens	115-126
9174666-8	1997	That the ganglioside sialidase inhibitors in the culture medium indeed affected solely the cell surface enzyme and not also a lysosomal sialidase, was demonstrated in an experiment where the desialylation of exogenously added radioactive gangliosides was determined in absence and presence of NeuAc2en and NH4Cl, an inhibitor of lysosomal function.	Gangliosides	238-250	neuraminidase 3	Homo sapiens	9-30
9186914-8	1997	These findings, together with the observation that anti-CD4 co-immunoprecipitated GM3, support the hypothesis of a possible GM3-CD4 interaction and suggest a role for gangliosides as structural components of the membrane multimolecular signaling complex involved in T-cell activation, antigen recognition, and other dynamic lymphocytic plasma membrane functions.	Gangliosides	167-179	CD4 molecule	Homo sapiens	56-59
9089210-7	1997	Insulin and IGF-I induced a neuritogenic response that was less potent than that of PDGF and was also inhibited by gangliosides.	Gangliosides	115-127	insulin	Homo sapiens	0-7
9108463-9	1997	Differences in GalNAc-T gene expression between the solid tumors and the cultured tumor cells correlate with the expression of ganglioside GM2.	Gangliosides	127-138	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	15-23
9108463-9	1997	Differences in GalNAc-T gene expression between the solid tumors and the cultured tumor cells correlate with the expression of ganglioside GM2.	Gangliosides	127-138	cytochrome b5 domain containing 2	Mus musculus	139-142
9089210-7	1997	Insulin and IGF-I induced a neuritogenic response that was less potent than that of PDGF and was also inhibited by gangliosides.	Gangliosides	115-127	insulin like growth factor 1	Homo sapiens	12-17
9224965-1	1997	In rat basophilic leukemia 2H3 (RBL-2H3) cells, mAb AA4 binds to two derivatives of ganglioside GD1b that associate with the Src family kinase p53/56lyn and a serine kinase.	Gangliosides	84-95	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	143-146
9037173-6	1997	Binding to the ganglioside is likely to modulate the neurotoxic and/or amyloidogenic properties of A beta(1-40).	Gangliosides	15-26	amyloid beta precursor protein	Homo sapiens	99-105
8900233-1	1996	Lysosomal degradation of ganglioside GM2 by beta-hexosaminidase A (hex A) requires the presence of the GM2 activator protein (GM2AP) as an essential cofactor.	Gangliosides	25-36	hexosaminidase subunit alpha	Homo sapiens	67-72
8999828-1	1997	The inhibition of protrusional activity, cell spreading, and cytokinesis induced by fumonisin B1 can be reversed by ganglioside GM3.	Gangliosides	116-127	granulocyte macrophage antigen 3	Mus musculus	128-131
9088372-3	1997	Ganglioside GD3 was increased in 17 of the tumour tissues and in 6 of the surrounding area specimens.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
9816154-0	1996	Activation of human effector cells by a tumor reactive recombinant anti-ganglioside GD2 interleukin-2 fusion protein (ch14.18-IL2).	Gangliosides	72-83	interleukin 2	Homo sapiens	88-101
9816154-0	1996	Activation of human effector cells by a tumor reactive recombinant anti-ganglioside GD2 interleukin-2 fusion protein (ch14.18-IL2).	Gangliosides	72-83	interleukin 2	Homo sapiens	126-129
9117545-3	1996	The percentage distribution of individual gangliosides was characterized by marked increases in GD3 and GD2, contrasting with severe decreases in GD1a, GD1b, GT1b and GQ1b; such changes were found throughout the patients" nervous tissues.	Gangliosides	42-54	GRDX	Homo sapiens	96-99
8995428-1	1997	Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants (Yang, L. J.-S., Zeller, C. B., Shaper, N. L., Kiso, M., Hasegawa, A., Shapiro, R. E., and Schnaar, R. L. (1996) Proc.	Gangliosides	151-163	LOC103161439	Cricetulus griseus	0-30
8995428-1	1997	Myelin-associated glycoprotein (MAG), a nervous system cell adhesion molecule, is an I-type lectin that binds to sialylated glycoconjugates, including gangliosides bearing characteristic structural determinants (Yang, L. J.-S., Zeller, C. B., Shaper, N. L., Kiso, M., Hasegawa, A., Shapiro, R. E., and Schnaar, R. L. (1996) Proc.	Gangliosides	151-163	LOC103161439	Cricetulus griseus	32-35
8995428-9	1997	MAG-expressing Chinese hamster ovary cells bound directly to gangliosides resolved on thin layer chromatograms, allowing detection of MAG binding species in a mixture.	Gangliosides	61-73	LOC103161439	Cricetulus griseus	0-3
8995428-9	1997	MAG-expressing Chinese hamster ovary cells bound directly to gangliosides resolved on thin layer chromatograms, allowing detection of MAG binding species in a mixture.	Gangliosides	61-73	LOC103161439	Cricetulus griseus	134-137
8995428-10	1997	The simplest ganglioside ligand for MAG was GM3 bearing N-acetylneuraminic acid, whereas GM3 bearing N-glycolylneuraminic acid did not support adhesion.	Gangliosides	13-24	LOC103161439	Cricetulus griseus	36-39
8995428-14	1997	These data demonstrate that MAG-ganglioside binding is highly specific and defines key carbohydrate structural determinants for MAG-mediated cell adhesion to gangliosides.	Gangliosides	158-170	LOC103161439	Cricetulus griseus	28-31
8995428-14	1997	These data demonstrate that MAG-ganglioside binding is highly specific and defines key carbohydrate structural determinants for MAG-mediated cell adhesion to gangliosides.	Gangliosides	158-170	LOC103161439	Cricetulus griseus	128-131
8995443-3	1997	Ganglioside synthesis and content of LAN-5 cells exposed for 6 days to 10 microM D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-PDMP) (an inhibitor of glucosylceramide synthase) were reduced by >90%.	Gangliosides	0-11	UDP-glucose ceramide glucosyltransferase	Homo sapiens	164-189
9043018-3	1997	The total amount of gangliosides in M4Be and its seven sublines was determined by cell extraction and thin-layer chromatography, while the expression of GD3 gangliosides was estimated by flow cytometry with a monoclonal antibody.	Gangliosides	157-169	GRDX	Homo sapiens	153-156
9034210-1	1997	Previous findings with various murine tumor cell lines suggest an association between ganglioside GM3 and cell cohesive properties.	Gangliosides	86-97	granulocyte macrophage antigen 3	Mus musculus	98-101
8981927-2	1996	We demonstrate here that a genetically engineered fusion protein consisting of human/mouse chimeric anti-ganglioside GD2 antibody and human interleukin-2 is able to induce eradication of established B78-D14 melanoma metastases in immunocompetent syngeneic C57BL/6J mice.	Gangliosides	105-116	interleukin 2	Homo sapiens	140-153
8906807-6	1996	This may be accounted for by the ability of gangliosides to prevent the activation of NF-kappaB in mitogen-stimulated T cells.	Gangliosides	44-56	nuclear factor kappa B subunit 1	Homo sapiens	86-95
8900233-1	1996	Lysosomal degradation of ganglioside GM2 by beta-hexosaminidase A (hex A) requires the presence of the GM2 activator protein (GM2AP) as an essential cofactor.	Gangliosides	25-36	ganglioside GM2 activator	Homo sapiens	103-124
8900233-1	1996	Lysosomal degradation of ganglioside GM2 by beta-hexosaminidase A (hex A) requires the presence of the GM2 activator protein (GM2AP) as an essential cofactor.	Gangliosides	25-36	ganglioside GM2 activator	Homo sapiens	126-131
9007268-0	1996	Synthesis and biological activities of three sulfated sialyl Le(x) ganglioside analogues for clarifying the real carbohydrate ligand structure of L-selectin.	Gangliosides	67-78	selectin L	Homo sapiens	146-156
9007268-1	1996	Sulfated sialyl Le(x) ganglioside analogues at C-6 of D-galactose, N-acetyl-D-glucosamine, and of both D-galactose and N-acetyl-D-glucosamine residues have been synthesized, in order to clarify the structure of the real carbohydrate ligand of L-selectin.	Gangliosides	22-33	selectin L	Homo sapiens	243-253
8871609-1	1996	The ganglioside GD3 is preferentially expressed on the surface of malignant T cell lymphoblasts and on resting T cells which express the memory cell phenotype, CD45RA-CD29+.	Gangliosides	4-15	GRDX	Homo sapiens	16-19
8863523-2	1996	Prominent among these is cholera toxin (CT), which consists of a pentameric B subunit that binds to ganglioside GM1 and an A subunit that mediates toxicity.	Gangliosides	100-111	coenzyme Q10A	Mus musculus	112-115
8871598-2	1996	A major mechanism of T-cell immunosuppression by gangliosides in vitro entails blocking of the interaction of interleukin-2 (IL-2) with its receptor; however, its involvement in immune suppression by gangliosides shed by tumor cells is not known.	Gangliosides	49-61	interleukin 2	Mus musculus	110-123
8871598-2	1996	A major mechanism of T-cell immunosuppression by gangliosides in vitro entails blocking of the interaction of interleukin-2 (IL-2) with its receptor; however, its involvement in immune suppression by gangliosides shed by tumor cells is not known.	Gangliosides	49-61	interleukin 2	Mus musculus	125-129
8871598-4	1996	Gangliosides shed by YAC-1 into the culture medium were present mainly in micellar form.	Gangliosides	0-12	ADP-ribosyltransferase 1	Mus musculus	21-26
8871609-1	1996	The ganglioside GD3 is preferentially expressed on the surface of malignant T cell lymphoblasts and on resting T cells which express the memory cell phenotype, CD45RA-CD29+.	Gangliosides	4-15	integrin subunit beta 1	Homo sapiens	167-171
8871598-8	1996	Taken together, these data suggest that one mechanism by which ganglioside micelles shed from YAC-1 exert their immunosuppressive effects on T-cells involves blocking the IL-2/IL-2 receptor system.	Gangliosides	63-74	ADP-ribosyltransferase 1	Mus musculus	94-99
8871598-8	1996	Taken together, these data suggest that one mechanism by which ganglioside micelles shed from YAC-1 exert their immunosuppressive effects on T-cells involves blocking the IL-2/IL-2 receptor system.	Gangliosides	63-74	interleukin 2	Mus musculus	171-175
8871598-8	1996	Taken together, these data suggest that one mechanism by which ganglioside micelles shed from YAC-1 exert their immunosuppressive effects on T-cells involves blocking the IL-2/IL-2 receptor system.	Gangliosides	63-74	interleukin 2	Mus musculus	176-180
8814260-9	1996	In contrast, incubation of HLA-DR7-specific clones with t-DR7 in the presence of R24 did result in phosphorylation of IL-2R related Jak kinases after 24 h. Our data indicate that the membrane ganglioside GD3 structure recognized by R24 may play an important role in antigen-specific T cell clonal response.	Gangliosides	192-203	interleukin 2 receptor, alpha chain	Mus musculus	118-123
8902189-2	1996	We have previously reported light microscopic pleiomorphic changes in cells suggestive of altered plasma membranes, an increase in globotriaosylceramide (Gb3), reflected by an increase in Gb3 on the surface of the plasma membrane, and a decrease in the rate and amount of ganglioside synthesized.	Gangliosides	272-283	alpha 1,4-galactosyltransferase (P blood group)	Homo sapiens	154-157
8823358-0	1996	Human melanoma cell lines deficient in GD3 ganglioside expression exhibit altered growth and tumorigenic characteristics.	Gangliosides	43-54	GRDX	Homo sapiens	39-42
8806633-4	1996	An antisense oligonucleotide derived from the rat GD3-synthase cDNA was applied to the cultures of rat cerebellar neurons and results showed a decrease in the synthesis of ganglioside GD3, indicating that the expression of GD3-synthase was modulated by the antisense sequence.	Gangliosides	172-183	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	50-62
8806633-4	1996	An antisense oligonucleotide derived from the rat GD3-synthase cDNA was applied to the cultures of rat cerebellar neurons and results showed a decrease in the synthesis of ganglioside GD3, indicating that the expression of GD3-synthase was modulated by the antisense sequence.	Gangliosides	172-183	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	223-235
8900435-9	1996	Our data suggest that (i) protein-bound sLe(a) oligosaccharides represent only a minor portion of whole sLe(a) antigen produced by uroepithelial cells; (ii) effective binding to E-selectin occurs when sLe(a) oligosaccharide present on cell-surface glycosphingolipids is expressed in high density since the cell lines with moderate expression of sLe(a) ganglioside did not bind to E-selectin-transfected CHO cells.	Gangliosides	352-363	selectin E	Homo sapiens	178-188
8855236-9	1996	The higher levels of GM3 and GD3 expressed in the brains of these mutant mice may be able to compensate for the lack of complex gangliosides.	Gangliosides	128-140	granulocyte macrophage antigen 3	Mus musculus	21-24
8895547-10	1996	Our results indicate that precursor ganglioside GM3 and gangliosides GD3 and GD2 could be associated with neoplastic evolution of malignancy of human uveal melanoma in nude mice.	Gangliosides	36-47	GRDX	Homo sapiens	69-72
8895547-10	1996	Our results indicate that precursor ganglioside GM3 and gangliosides GD3 and GD2 could be associated with neoplastic evolution of malignancy of human uveal melanoma in nude mice.	Gangliosides	56-68	GRDX	Homo sapiens	69-72
8823909-2	1996	Recently, minor gangliosides of granulocytes were characterized and found to express sialyl Lewis(x) and VIM-2 epitopes.	Gangliosides	16-28	vimentin 2, pseudogene	Homo sapiens	105-110
8882979-0	1996	Enhancement by ganglioside GT1b of annexin I phosphorylation in bovine mammary gland in the presence of phosphatidylserine and Ca2+.	Gangliosides	15-26	annexin A1	Bos taurus	35-44
9064322-3	1996	Coupling of antigen-containing particles to the pentameric binding subunit of cholera toxin (CTB) has been proposed as a means for increasing antigen uptake because the CTB receptor, ganglioside GM1, is a glycolipid present in apical membranes of all intestinal epithelial cells.	Gangliosides	183-194	chitobiase	Homo sapiens	93-96
9064322-3	1996	Coupling of antigen-containing particles to the pentameric binding subunit of cholera toxin (CTB) has been proposed as a means for increasing antigen uptake because the CTB receptor, ganglioside GM1, is a glycolipid present in apical membranes of all intestinal epithelial cells.	Gangliosides	183-194	chitobiase	Homo sapiens	169-172
8906573-0	1996	Ganglioside effects on basic fibroblast and epidermal growth factor receptors in retinal glial cells.	Gangliosides	0-11	epidermal growth factor	Homo sapiens	44-67
8906574-3	1996	With the transfection of cDNA encoding GD3 synthase, the de novo synthesis and expression of GD3 and b-series gangliosides occurred, and, furthermore, it induced the growth of axon-like neurites and cholinergic differentiation of Neuro2a cells.	Gangliosides	110-122	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	39-51
8819493-1	1996	GD3 is the most prominent ganglioside on the surface of human melanoma cells, and therefore it has been considered by several investigators as a potential tool for active immunotherapy of melanoma.	Gangliosides	26-37	GRDX	Homo sapiens	0-3
8819493-8	1996	Immunization of mice with sphingomyelin:cholesterol:dicetyl-phosphate:GD3, molar ratio 40:40:10:10, liposomes resulted in good IgM and IgG3 anti-GD3 response, with a maximum titer of 1:1200 and absence of significant cross-reactivity with other gangliosides.	Gangliosides	245-257	GRDX	Homo sapiens	70-73
8864846-0	1996	Interaction of ganglioside with specific peptide sequences as a mechanism for the modulation of calmodulin-dependent enzymes.	Gangliosides	15-26	calmodulin 1	Homo sapiens	96-106
8757818-0	1996	Miller-Fisher syndrome associated with Campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside GD3.	Gangliosides	114-125	GRDX	Homo sapiens	126-129
8757818-5	1996	Chemical analysis of the LPS revealed that the core oligosaccharide has a terminal trisaccharide epitope consisting of two molecules of sialic acid linked to galactose, a structure reflecting the terminal region of human ganglioside GD3.	Gangliosides	221-232	GRDX	Homo sapiens	233-236
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	36-48	calmodulin 1	Homo sapiens	75-85
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	36-48	calmodulin 1	Homo sapiens	87-90
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	36-48	calmodulin 1	Homo sapiens	182-185
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	161-173	calmodulin 1	Homo sapiens	75-85
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	161-173	calmodulin 1	Homo sapiens	87-90
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	161-173	calmodulin 1	Homo sapiens	182-185
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	161-173	calmodulin 1	Homo sapiens	75-85
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	161-173	calmodulin 1	Homo sapiens	87-90
8864846-1	1996	We examined the interaction between gangliosides and synthetic peptides of calmodulin (CaM)-dependent enzymes to confirm the hypothesis that interaction between gangliosides and the CaM-like site (CLS) of the enzyme is a mechanism for the modulation of the enzyme activity by gangliosides.	Gangliosides	161-173	calmodulin 1	Homo sapiens	182-185
8864846-2	1996	Gangliosides, GD1b, GT1b, and GD1a, inhibited the activity of CaM-independently activated cAMP-phosphodiesterase and their inhibition was cancelled by a peptide consisting of 17 amino acid residues of a plasma membrane Ca(2+)-pump CLS, suggesting the involvement of the interaction between the peptide and the gangliosides.	Gangliosides	0-12	calmodulin 1	Homo sapiens	62-65
8864846-2	1996	Gangliosides, GD1b, GT1b, and GD1a, inhibited the activity of CaM-independently activated cAMP-phosphodiesterase and their inhibition was cancelled by a peptide consisting of 17 amino acid residues of a plasma membrane Ca(2+)-pump CLS, suggesting the involvement of the interaction between the peptide and the gangliosides.	Gangliosides	310-322	calmodulin 1	Homo sapiens	62-65
8864846-4	1996	On the other hand, the gangliosides interacted with synthetic CaM-binding site (CBS) peptides of phosphodiesterase, calcineurin, Ca(2+)-pump, and Ca2+/calmodulin-dependent protein kinase II.	Gangliosides	23-35	calmodulin 1	Homo sapiens	62-65
8864846-4	1996	On the other hand, the gangliosides interacted with synthetic CaM-binding site (CBS) peptides of phosphodiesterase, calcineurin, Ca(2+)-pump, and Ca2+/calmodulin-dependent protein kinase II.	Gangliosides	23-35	calmodulin 1	Homo sapiens	151-161
8864846-6	1996	On the basis of these new findings, we propose a revised model for the ganglioside-mediated modulation of CaM-dependent enzymes, i.e. without CaM, gangliosides bind to CBS and thus stimulate the enzyme activity, acting like CaM.	Gangliosides	71-82	calmodulin 1	Homo sapiens	106-109
8864846-6	1996	On the basis of these new findings, we propose a revised model for the ganglioside-mediated modulation of CaM-dependent enzymes, i.e. without CaM, gangliosides bind to CBS and thus stimulate the enzyme activity, acting like CaM.	Gangliosides	147-159	calmodulin 1	Homo sapiens	106-109
9139460-5	1996	Main tumour gangliosides were shown to be GM3 and GD3.	Gangliosides	12-24	GRDX	Homo sapiens	50-53
8679447-7	1996	Gangliosides GD3 and GT3 were detected in many seminomas, but rarely in embryonal carcinomas.	Gangliosides	0-12	GRDX	Homo sapiens	13-16
9139460-6	1996	Their content decreases in malignant ovary tumours, especially the amount of ganglioside GD3.	Gangliosides	77-88	GRDX	Homo sapiens	89-92
8632182-1	1996	Preincubation of botulinum neurotoxin serotype A, B, or E with ganglioside GT1b was previously found to enhance adherence of botulinum neurotoxin to synapsin I and an approximately 116-kDa bovine brain synaptosomal protein; in contrast, adherence to these two proteins by tetanus neurotoxin required preincubation with GT1b.	Gangliosides	63-74	synapsin-1	Bos taurus	149-159
8665524-0	1996	High expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthase) gene in adult T-cell leukemia cells unrelated to the gene expression of human T-lymphotropic virus type I.	Gangliosides	19-30	GRDX	Homo sapiens	60-63
8665524-1	1996	Expression of ganglioside alpha-2,8-sialyltransferase (GD3 synthetase; EC 2.4.99.8) gene and gangliosides in human leukemia cells were analyzed.	Gangliosides	14-25	GRDX	Homo sapiens	55-58
8827457-3	1996	To explore the functional significance of the change, we examined the role of neutral glycosphingolipids as receptors for the murine pulmonary surfactant protein, SP-A, and found that SP-A bound to LacCer, Gg3Cer, and Gg1Cer, but not to Gb3Cer, Gb4Cer, IV3GalNAc alpha-Gb4Cer, sulfatide, or several gangliosides.	Gangliosides	299-311	surfactant associated protein A1	Mus musculus	184-188
8640753-2	1996	Ganglioside GD3, is one of the major gangliosides which has been implicated in tumour angiogenesis.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
8640753-2	1996	Ganglioside GD3, is one of the major gangliosides which has been implicated in tumour angiogenesis.	Gangliosides	37-49	GRDX	Homo sapiens	12-15
8706663-1	1996	To address the role of alpha2,8-sialyltransferase (GD3 synthase) in the biosynthesis of gangliosides, we examined the substrate specificity of the enzyme.	Gangliosides	88-100	GRDX	Homo sapiens	51-54
8706663-2	1996	In the ganglioside synthesis pathway, it has been generally accepted that sialyltransferase II (SAT II) catalyzes the production of GD3 from GM3, and sialyltransferase V (SAT V) catalyzes the production of GD1c/GT1a/GQ1b from GM1h/GD1a/GT1b.	Gangliosides	7-18	GRDX	Homo sapiens	132-135
8804704-4	1996	A considerable number of GalC+ oligodendrocytes expressed intense immunoreactivities specific for GM3 (19%) and GM2 (45%) gangliosides.	Gangliosides	122-134	galactosylceramidase	Homo sapiens	25-29
8662799-8	1996	Gangliosides also inhibited the NADase activity of the extracellular domain of CD38 antigen that was deprived of the transmembrane domain and was expressed in Escherichia coli as a fusion protein with maltose-binding protein (MBP-CD38).	Gangliosides	0-12	CD38 molecule	Homo sapiens	79-83
8662799-8	1996	Gangliosides also inhibited the NADase activity of the extracellular domain of CD38 antigen that was deprived of the transmembrane domain and was expressed in Escherichia coli as a fusion protein with maltose-binding protein (MBP-CD38).	Gangliosides	0-12	myelin basic protein	Homo sapiens	226-229
8662799-8	1996	Gangliosides also inhibited the NADase activity of the extracellular domain of CD38 antigen that was deprived of the transmembrane domain and was expressed in Escherichia coli as a fusion protein with maltose-binding protein (MBP-CD38).	Gangliosides	0-12	CD38 molecule	Homo sapiens	230-234
8662799-9	1996	The order of the inhibitory effect of purified ganglioside species on the NADase activity on MBP-CD38 was as follows: GQ1balpha > GT1b, GQ1b > GD1a, GD1b, GM1a, GM1b, GD3, GM3.	Gangliosides	47-58	myelin basic protein	Homo sapiens	93-96
8662799-0	1996	Inhibition of NAD+ glycohydrolase and ADP-ribosyl cyclase activities of leukocyte cell surface antigen CD38 by gangliosides.	Gangliosides	111-123	CD38 molecule	Homo sapiens	103-107
8662799-4	1996	Here, we investigated the effect of gangliosides on the enzymatic activity of leukocyte cell surface antigen CD38, which is identified as an ecto-NADase (Kontani, K., Nishina, H., Ohoka, Y., Takahashi, K., and Katada, T. (1993) J. Biol.	Gangliosides	36-48	CD38 molecule	Homo sapiens	109-113
8662799-7	1996	Gangliosides GM1a and GQ1balpha inhibited the NADase activity in the immunoprecipitate of anti-CD38 antibody from the membrane extract of retinoic acid-treated human leukemic HL-60 cells.	Gangliosides	0-12	CD38 molecule	Homo sapiens	95-99
8662799-9	1996	The order of the inhibitory effect of purified ganglioside species on the NADase activity on MBP-CD38 was as follows: GQ1balpha > GT1b, GQ1b > GD1a, GD1b, GM1a, GM1b, GD3, GM3.	Gangliosides	47-58	CD38 molecule	Homo sapiens	97-101
8635555-0	1996	The ganglioside GM1 enhances microtubule networks and changes the morphology of Neuro-2a cells in vitro by altering the distribution of MAP2.	Gangliosides	4-15	microtubule-associated protein 2	Mus musculus	136-140
8662799-13	1996	At present, gangliosides are the only endogenous species that can block the enzymatic activity of CD38 antigen.	Gangliosides	12-24	CD38 molecule	Homo sapiens	98-102
8639583-2	1996	SPR shows that cholera toxin preferably binds to gangliosides in the following sequence: GM1 > GM2 > GD1A > GM3 > GT1B > GD1B > asialo-GM1.	Gangliosides	49-61	sepiapterin reductase	Homo sapiens	0-3
9011371-0	1996	Synthesis of sialyl Le(x) ganglioside analogues sulfated at C-6 of either the galactose or N-acetylglucosamine residues, and at both of the galactose and N-acetylglucosamine residues: probes for clarifying the real carbohydrate ligand of L-selectin.	Gangliosides	26-37	complement C6	Homo sapiens	60-63
9011371-0	1996	Synthesis of sialyl Le(x) ganglioside analogues sulfated at C-6 of either the galactose or N-acetylglucosamine residues, and at both of the galactose and N-acetylglucosamine residues: probes for clarifying the real carbohydrate ligand of L-selectin.	Gangliosides	26-37	selectin L	Homo sapiens	238-248
8631864-12	1996	Like GM2 activator protein, GM2A protein also specifically recognized the terminal GM2 epitope in GalNAc-GD1a and stimulated the hydrolysis of only the external NeuAc from this ganglioside by clostridial sialidase.	Gangliosides	177-188	ganglioside GM2 activator	Homo sapiens	28-32
8635555-5	1996	Our results suggest that gangliosides enhance neuritogenesis by selectively altering the distribution of MAP2 from perikaryon to neuritic spines.	Gangliosides	25-37	microtubule-associated protein 2	Mus musculus	105-109
8724144-6	1996	The role of the plasma membrane sialidase in gangliosides desialylation of living cells was examined by following the fate of [3H]galactose-labelled individual gangliosides in pulse-chase experiments in absence and presence of the extracellular sialidase inhibitor 2-deoxy-2,3-dehydro-N-acetylneuraminic acid.	Gangliosides	45-57	neuraminidase 3	Homo sapiens	23-41
8780032-6	1996	Differences in the relative content of Fc receptor-bearing cells in ependymoblastoma and CT-2A tumors grown in vivo (8.3 and 16.8%, respectively) were proportional to differences in the relative content of NeuGc-containing gangliosides (25.5 and 45.1%) and GA1 (8.5 and 13.8%), respectively.	Gangliosides	223-235	Fc receptor	Mus musculus	39-50
8738127-4	1996	We have previously shown that cholera toxin B subunit (CTB), which binds to the ganglioside GM1, binds heterogeneously to dissociated neuroepithelial cells from the developing mouse telencephalon.	Gangliosides	80-91	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	30-53
8738127-4	1996	We have previously shown that cholera toxin B subunit (CTB), which binds to the ganglioside GM1, binds heterogeneously to dissociated neuroepithelial cells from the developing mouse telencephalon.	Gangliosides	80-91	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	55-58
8738127-4	1996	We have previously shown that cholera toxin B subunit (CTB), which binds to the ganglioside GM1, binds heterogeneously to dissociated neuroepithelial cells from the developing mouse telencephalon.	Gangliosides	80-91	coenzyme Q10A	Mus musculus	92-95
8603372-0	1996	Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro.	Gangliosides	63-75	vascular endothelial growth factor A	Homo sapiens	0-34
8603372-3	1996	TGF-beta isoforms and gangliosides were found to differentially stimulate VEGF production by these cells.	Gangliosides	22-34	vascular endothelial growth factor A	Homo sapiens	74-78
8603372-4	1996	The ganglioside GD3 enhanced this release to the greatest extent and the stimulation was more marked in a glioblastoma cell line than in the two other anaplastic astrocytoma cell lines.	Gangliosides	4-15	GRDX	Homo sapiens	16-19
8603372-5	1996	These results suggest that both TGF-betas and gangliosides may act as indirect angiogenic factors by stimulating VEGF secretion.	Gangliosides	46-58	vascular endothelial growth factor A	Homo sapiens	113-117
8606382-14	1996	When NK activity was suppressed by asialoGM1 ganglioside antibody in BALB/cByJ mice or in C.B-17/IcrCrl-SCID/Beige mice, the antimetastatic effect of IL-10 was lost.	Gangliosides	45-56	interleukin 10	Mus musculus	150-155
8724144-7	1996	When the plasma membrane sialidase was inhibited, radioactivity of all gangliosides chased at the same rate.	Gangliosides	71-83	neuraminidase 3	Homo sapiens	16-34
8724144-9	1996	The results thus suggest that the plasma membrane sialidase causes selective ganglioside desialylation, and that such surface glycolipid modification triggers growth control and differentiation in human neuroblastoma cells.	Gangliosides	77-88	neuraminidase 3	Homo sapiens	41-59
8737244-0	1996	Prosaposin and prosaptide, a peptide from prosaposin, induce an increase in ganglioside content on NS20Y neuroblastoma cells.	Gangliosides	76-87	prosaposin	Mus musculus	0-10
8737244-0	1996	Prosaposin and prosaptide, a peptide from prosaposin, induce an increase in ganglioside content on NS20Y neuroblastoma cells.	Gangliosides	76-87	prosaposin	Mus musculus	42-52
8737244-2	1996	In this paper we investigate whether prosaposin and its active peptide (prosaptide) may modify the ganglioside pattern in neuroblastoma cells.	Gangliosides	99-110	prosaposin	Mus musculus	37-47
8737244-5	1996	These findings suggest that the neurotrophic activity of prosaposin on NS20Y neuroblastoma cells might be mediated in part by the increase of cell surface gangliosides.	Gangliosides	155-167	prosaposin	Mus musculus	57-67
8737250-0	1996	Interleukin-3-associated ganglioside GD1a is induced independently of normal interleukin-3 receptor in murine myelogenous leukaemia NFS60 cells transfected with the interleukin-3 gene.	Gangliosides	25-36	interleukin 3	Mus musculus	0-13
8737250-0	1996	Interleukin-3-associated ganglioside GD1a is induced independently of normal interleukin-3 receptor in murine myelogenous leukaemia NFS60 cells transfected with the interleukin-3 gene.	Gangliosides	25-36	interleukin 3	Mus musculus	165-178
8737250-1	1996	The mechanism of interleukin-3 (IL-3) independent cell growth and of IL-3-associated ganglioside expression was analysed using the IL-3 dependent murine myelogenous leukaemia cell line NFS60-I7 and IL-3 gene-transfected sublines.	Gangliosides	85-96	interleukin 3	Mus musculus	69-73
8737250-1	1996	The mechanism of interleukin-3 (IL-3) independent cell growth and of IL-3-associated ganglioside expression was analysed using the IL-3 dependent murine myelogenous leukaemia cell line NFS60-I7 and IL-3 gene-transfected sublines.	Gangliosides	85-96	interleukin 3	Mus musculus	69-73
9081368-3	1996	In this descriptive study, we investigated the effects of six exogenous gangliosides (GM1, GM3, GD1a, GD1b, GD3 and GT1b) on the secretion of MMP-2 (72 kDa gelatinase or gelatinase-A) and MMP-9 (92 kDa gelatinase or gelatinase-B).	Gangliosides	72-84	matrix metallopeptidase 2	Homo sapiens	142-147
8859901-7	1996	These findings suggest that the NH(2)-terminal domain of synaptotagmin II forms the binding site for type B neurotoxin by associating with specific gangliosides in presynaptic plasma membranes.	Gangliosides	148-160	synaptotagmin 2	Rattus norvegicus	57-73
8721669-0	1996	A reappraisal of ganglioside GD3 expression in the CNS.	Gangliosides	17-28	GRDX	Homo sapiens	29-32
8721672-1	1996	Neurotrophic factors such as basic fibroblast and epidermal factor (bFGF and EGF respectively) are known to influence many differentiative processes, but their effects on an important group of glycosylated signalling molecules involved in neural differentiation, the gangliosides, are unknown.	Gangliosides	267-279	fibroblast growth factor 2	Homo sapiens	68-80
8721672-2	1996	To study this possibility, we analyzed the effects of exogenously added bFGF and EGF upon the amount and type of endogenous gangliosides extracted from purified cultures of retinal Muller glial cells.	Gangliosides	124-136	fibroblast growth factor 2	Homo sapiens	72-76
8721672-3	1996	A single addition of 500 pM bFGF or EGF for 48 h to such cultures led to significant increases in total ganglioside levels of 30-40%.	Gangliosides	104-115	fibroblast growth factor 2	Homo sapiens	28-32
8721672-3	1996	A single addition of 500 pM bFGF or EGF for 48 h to such cultures led to significant increases in total ganglioside levels of 30-40%.	Gangliosides	104-115	epidermal growth factor	Homo sapiens	36-39
8721672-6	1996	Furthermore, growth factor-induced ganglioside increases were dose-dependent, reaching maximal stimulation at 500 pM for bFGF.	Gangliosides	35-46	fibroblast growth factor 2	Homo sapiens	121-125
8737250-1	1996	The mechanism of interleukin-3 (IL-3) independent cell growth and of IL-3-associated ganglioside expression was analysed using the IL-3 dependent murine myelogenous leukaemia cell line NFS60-I7 and IL-3 gene-transfected sublines.	Gangliosides	85-96	interleukin 3	Mus musculus	69-73
8737250-2	1996	The transfected cell lines showed autonomous cell growth, tumorigenicity, and IL-3 associated ganglioside GD1a expression in spite of their IL-3 production.	Gangliosides	94-105	interleukin 3	Mus musculus	78-82
8601692-5	1996	However, it could act as a glycolipid transfer protein, since several gangliosides (a series) were found to bind with high affinity to prosaposin.	Gangliosides	70-82	prosaposin	Rattus norvegicus	135-145
8839455-0	1996	Control by ganglioside GD1a of phospholipase A2 activity through modulation of the lamellar-hexagonal (HII) phase transition.	Gangliosides	11-22	phospholipase A2 group IB	Homo sapiens	31-47
8622736-0	1996	IgM M-protein with antibody activity against gangliosides with disialosyl residue in sensory neuropathy binds to sensory neurons.	Gangliosides	45-57	myomesin 2	Homo sapiens	4-13
8935335-0	1996	Alteration of human melanoma gangliosides by IFN-gamma, IL-2, and IL-4.	Gangliosides	29-41	interferon gamma	Homo sapiens	45-54
8935335-0	1996	Alteration of human melanoma gangliosides by IFN-gamma, IL-2, and IL-4.	Gangliosides	29-41	interleukin 2	Homo sapiens	56-60
8935335-0	1996	Alteration of human melanoma gangliosides by IFN-gamma, IL-2, and IL-4.	Gangliosides	29-41	interleukin 4	Homo sapiens	66-70
8935335-4	1996	IFN-gamma increases the ratio of a-series gangliosides and the ratio of GM3/GD3.	Gangliosides	42-54	interferon gamma	Homo sapiens	0-9
8839455-6	1996	The effects of GD1a are probably due to the geometrical features of the ganglioside molecule that allow a composition-dependent compensation of the structural defects required for the formation of the HII phase which are detected by phospholipase A2.	Gangliosides	72-83	phospholipase A2 group IB	Homo sapiens	233-249
8631773-10	1996	Of these three, ST6GalNAc III displays the most restricted acceptor specificity and is the only sialyltransferase cloned to date capable of forming the developmentally regulated ganglioside G(D1alpha) from G(M1b).	Gangliosides	178-189	ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3	Homo sapiens	16-29
8692038-1	1996	In a number of patients with tumours of either neuroectodermal or epithelial origin, polysialylated gangliosides (e.g. GD3) are over-expressed.	Gangliosides	100-112	GRDX	Homo sapiens	119-122
8631981-6	1996	GD3/GT3ST synthesized GT3 most efficiently when GM3, NeuNAcalpha2-->3Galbeta1-->4Glc-->Cer, was incubated as an acceptor, indicating that GD3/GT3ST is a polysialyltransferase that can transfer more than one sialic acid residue via alpha-2,8 linkage to gangliosides.	Gangliosides	261-273	GRDX	Homo sapiens	0-3
8631981-6	1996	GD3/GT3ST synthesized GT3 most efficiently when GM3, NeuNAcalpha2-->3Galbeta1-->4Glc-->Cer, was incubated as an acceptor, indicating that GD3/GT3ST is a polysialyltransferase that can transfer more than one sialic acid residue via alpha-2,8 linkage to gangliosides.	Gangliosides	261-273	GRDX	Homo sapiens	0-9
8631981-11	1996	Taken together, these results indicate that C series polysialogangliosides are synthesized by a ganglioside-specific polysialyltransferase, GD3/GT3ST, that is specifically expressed in neural tissues.	Gangliosides	62-73	GRDX	Homo sapiens	140-149
8604015-3	1996	Gangliosides have been indirectly implicated in macrophage migration as putative cell surface receptors for migration inhibitory factor (MIF).	Gangliosides	0-12	macrophage migration inhibitory factor	Homo sapiens	108-135
8604015-3	1996	Gangliosides have been indirectly implicated in macrophage migration as putative cell surface receptors for migration inhibitory factor (MIF).	Gangliosides	0-12	macrophage migration inhibitory factor	Homo sapiens	137-140
8882734-8	1996	Only immunization with Gfpt1-KLH conjugate in the presence of MPL stimulated selectively high anti-Gfpt1 antibody titers showing comparably low crossreactivity to ganglioside Gtet1.	Gangliosides	163-174	glutamine fructose-6-phosphate transaminase 1	Mus musculus	23-28
8547257-3	1996	E-selectin binding gangliosides were isolated from myelogenous leukemia HL60 cells, and the E-selectin binding pattern was compared with that of human neutrophils as described in the preceding paper in this issue.	Gangliosides	19-31	selectin E	Homo sapiens	0-10
8679258-2	1996	A specific goal addressed by our laboratory is to produce human MAbs to several ganglioside antigens of relevance as therapeutic targets, such as the GM2, GD2, GD3 and GM3 gangliosides in melanoma.	Gangliosides	80-91	GRDX	Homo sapiens	160-163
8557112-0	1996	The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a.	Gangliosides	105-117	synaptotagmin 2	Rattus norvegicus	72-88
8557112-5	1996	These results suggest that this region of synaptotagmin II participates in the formation of the high-affinity toxin binding site by associating with specific gangliosides.	Gangliosides	158-170	synaptotagmin 2	Rattus norvegicus	42-58
8719707-2	1996	Two long-chain bases, LCB, were components of the five major gangliosides GM1, GD1a, GD1b, GT1b and GQ1b, these being the C18:1 LCB and C20:1 LCB.	Gangliosides	61-73	clathrin, light chain B	Rattus norvegicus	22-25
8569195-3	1996	Levels of cell membrane CD59 were found to regulate the differential sensitivity of melanoma cells investigated to homologous C-mediated lysis; in fact, an inverse correlation (r > 0.7, p < 0.05) was found between levels of cell membrane CD59, but not of CD46 and CD55, and extent of C-mediated lysis of melanoma cells sensitized with scalar concentrations of the anti-GD3 ganglioside mAb R24.	Gangliosides	379-390	CD59 molecule (CD59 blood group)	Homo sapiens	24-28
8886247-7	1996	For both of them, GD3 was the most abundant ganglioside in colostrum, whilst in mature milk it was GM3.	Gangliosides	44-55	GRDX	Homo sapiens	18-21
8838579-2	1996	Actinomycin D or a mixture of protein synthesis inhibitors or of antisense oligonucleotides to c-fos plus c-jun injected intraocularly 1 hr prior to the stimulation period, abolished the light-dark differences for phospholipids but not for gangliosides.	Gangliosides	240-252	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-100
8838579-2	1996	Actinomycin D or a mixture of protein synthesis inhibitors or of antisense oligonucleotides to c-fos plus c-jun injected intraocularly 1 hr prior to the stimulation period, abolished the light-dark differences for phospholipids but not for gangliosides.	Gangliosides	240-252	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	106-111
8838579-3	1996	Light stimulation induced the formation (and/or stabilization) of c-fos mRNA and of the protein c-Fos, indicating that immediate early gene induction, and consequently the synthesis of the protein(s) encoded, is essential to increase the synthesis of phospholipids but not of gangliosides.	Gangliosides	276-288	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
8777139-5	1996	The galactose residues of asialo-hCG were reacted with NeuAc-hydrazone or a hydrazone of the oligosaccharide from the ganglioside GM1 (Gal(beta 1-3)GalNAc(beta 1-4) [NeuAc(alpha 2-3)]Gal(beta 1-4)Glc).	Gangliosides	118-129	chorionic gonadotropin subunit beta 5	Homo sapiens	33-36
8522963-2	1996	GM2/GD2 synthase and GD3 synthase are key enzymes for ganglioside synthesis, because their relative activities regulate the main profiles of ganglioside expression.	Gangliosides	54-65	cytochrome b5 domain containing 2	Mus musculus	0-3
8522963-2	1996	GM2/GD2 synthase and GD3 synthase are key enzymes for ganglioside synthesis, because their relative activities regulate the main profiles of ganglioside expression.	Gangliosides	54-65	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	21-33
8522963-2	1996	GM2/GD2 synthase and GD3 synthase are key enzymes for ganglioside synthesis, because their relative activities regulate the main profiles of ganglioside expression.	Gangliosides	141-152	cytochrome b5 domain containing 2	Mus musculus	0-3
8522963-2	1996	GM2/GD2 synthase and GD3 synthase are key enzymes for ganglioside synthesis, because their relative activities regulate the main profiles of ganglioside expression.	Gangliosides	141-152	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	21-33
8801533-0	1996	Interaction of alpha-MSH and substance P with interfaces containing gangliosides.	Gangliosides	68-80	proopiomelanocortin	Homo sapiens	15-24
8801543-5	1996	We conclude that the presence of gangliosides may facilitate the alpha-MSH interaction with its receptor, increasing the cAMP levels in slices containing the CP and Acc nuclei.	Gangliosides	33-45	proopiomelanocortin	Rattus norvegicus	65-74
8801533-0	1996	Interaction of alpha-MSH and substance P with interfaces containing gangliosides.	Gangliosides	68-80	tachykinin precursor 1	Homo sapiens	29-40
8801533-1	1996	In the present work we studied the interaction of alpha-MSH and substance P neuropeptides with gangliosides using lipid monolayers, fluorescence spectroscopy, and differential scanning calorimetry techniques.	Gangliosides	95-107	proopiomelanocortin	Homo sapiens	50-59
8801533-1	1996	In the present work we studied the interaction of alpha-MSH and substance P neuropeptides with gangliosides using lipid monolayers, fluorescence spectroscopy, and differential scanning calorimetry techniques.	Gangliosides	95-107	tachykinin precursor 1	Homo sapiens	64-75
8801533-10	1996	Both neuropeptides induced the same increment in the transition temperature Tm from 19 to 20.5 degrees C. The basic physicochemical studies herein indicated that both positively charged neuropeptides, alpha-MSH and substance P, interact with interfaces containing gangliosides in a mainly electrostatic form, whereas the hydrophobic interaction seems to play a secondary role.	Gangliosides	264-276	proopiomelanocortin	Homo sapiens	201-210
8801533-10	1996	Both neuropeptides induced the same increment in the transition temperature Tm from 19 to 20.5 degrees C. The basic physicochemical studies herein indicated that both positively charged neuropeptides, alpha-MSH and substance P, interact with interfaces containing gangliosides in a mainly electrostatic form, whereas the hydrophobic interaction seems to play a secondary role.	Gangliosides	264-276	tachykinin precursor 1	Homo sapiens	215-226
8801543-0	1996	Synergic action of gangliosides on alpha-MSH-induced cyclic AMP levels in rat brain slices.	Gangliosides	19-31	proopiomelanocortin	Rattus norvegicus	35-44
8801543-2	1996	In this study we explore the possibility that the increase in cAMP tissular levels induced by alpha-MSH may be modulated by the action of exogenously added gangliosides.	Gangliosides	156-168	proopiomelanocortin	Rattus norvegicus	94-103
8801543-3	1996	We measured the level of cAMP in both tissues and medium in response to the alpha-MSH in slices previously incubated with total bovine brain gangliosides (TBG).	Gangliosides	141-153	proopiomelanocortin	Rattus norvegicus	76-85
8530426-1	1995	The monoclonal antibody U5, which is a potent inducer of proliferation in human T-cells, was found to bind to an alkali-sensitive derivative of ganglioside GD3.	Gangliosides	144-155	GRDX	Homo sapiens	156-159
8550071-0	1995	Gangliosides are potent immunosuppressors of IL-2-mediated T-cell proliferation in a low protein environment.	Gangliosides	0-12	interleukin 2	Mus musculus	45-49
8847737-8	1995	Furthermore, only MBP interacted with ganglioside GM1, whereas MBP did not interact with this ganglioside.	Gangliosides	38-49	myelin basic protein	Homo sapiens	18-21
8847737-9	1995	These results are consistent with the view that ganglioside GM1 mediates the mitogenic effects of MBP, while the FGF receptor mediates the mitogenic effect of MBP.	Gangliosides	48-59	myelin basic protein	Homo sapiens	98-101
8847738-3	1995	MBP and MBP peptides (1-44 and 88-151) have been shown to interact with ganglioside GM1 (Tzeng et al.	Gangliosides	72-83	myelin basic protein	Homo sapiens	0-3
8847738-3	1995	MBP and MBP peptides (1-44 and 88-151) have been shown to interact with ganglioside GM1 (Tzeng et al.	Gangliosides	72-83	myelin basic protein	Homo sapiens	8-11
8550071-2	1995	One mechanism of immunosuppression by gangliosides in vitro involves competition with interleukin-2 receptors (IL-2R) for binding of IL-2.	Gangliosides	38-50	interleukin 2 receptor, alpha chain	Mus musculus	86-109
8550071-2	1995	One mechanism of immunosuppression by gangliosides in vitro involves competition with interleukin-2 receptors (IL-2R) for binding of IL-2.	Gangliosides	38-50	interleukin 2 receptor, alpha chain	Mus musculus	111-116
8550071-2	1995	One mechanism of immunosuppression by gangliosides in vitro involves competition with interleukin-2 receptors (IL-2R) for binding of IL-2.	Gangliosides	38-50	interleukin 2	Mus musculus	111-115
8550071-3	1995	Previous studies on inhibition of IL-2-mediated events by gangliosides have been conducted in the presence of high levels of fetal bovine serum (FBS).	Gangliosides	58-70	interleukin 2	Mus musculus	34-38
8550071-5	1995	In order to better mimic physiological conditions, we have examined immunosuppression by gangliosides towards IL-2-dependent HT-2 cells in a low serum-low protein medium.	Gangliosides	89-101	interleukin 2	Mus musculus	110-114
8550071-6	1995	The ability of gangliosides to inhibit IL-2-stimulated DNA synthesis in HT-2 increased dramatically as the serum concentration in the culture medium was decreased; the 50% inhibitory concentration (IC50) value for GM1 was 13 microM under low serum conditions, 14-fold lower than the value obtained in 10% FBS.	Gangliosides	15-27	interleukin 2	Mus musculus	39-43
8550071-6	1995	The ability of gangliosides to inhibit IL-2-stimulated DNA synthesis in HT-2 increased dramatically as the serum concentration in the culture medium was decreased; the 50% inhibitory concentration (IC50) value for GM1 was 13 microM under low serum conditions, 14-fold lower than the value obtained in 10% FBS.	Gangliosides	15-27	coenzyme Q10A	Mus musculus	214-217
8550071-7	1995	Further investigation revealed that the mechanism of immunosuppression by gangliosides in low serum-low protein medium involved interference with the IL-2/IL-2R system.	Gangliosides	74-86	interleukin 2	Mus musculus	150-154
8550071-7	1995	Further investigation revealed that the mechanism of immunosuppression by gangliosides in low serum-low protein medium involved interference with the IL-2/IL-2R system.	Gangliosides	74-86	interleukin 2 receptor, alpha chain	Mus musculus	155-160
8550071-8	1995	Ganglioside-mediated inhibition was dependent on the continued presence of the glycolipids during the first few hours after IL-2 stimulation, and could be reversed by increasing levels of IL-2.	Gangliosides	0-11	interleukin 2	Mus musculus	124-128
8550071-8	1995	Ganglioside-mediated inhibition was dependent on the continued presence of the glycolipids during the first few hours after IL-2 stimulation, and could be reversed by increasing levels of IL-2.	Gangliosides	0-11	interleukin 2	Mus musculus	188-192
8550071-9	1995	Receptor binding experiments demonstrated that gangliosides blocked the interaction of IL-2 with high-affinity IL-2 receptors on HT-2.	Gangliosides	47-59	interleukin 2	Mus musculus	87-91
8550071-9	1995	Receptor binding experiments demonstrated that gangliosides blocked the interaction of IL-2 with high-affinity IL-2 receptors on HT-2.	Gangliosides	47-59	interleukin 2	Mus musculus	111-115
8550071-10	1995	Taken together, these results support the view that gangliosides will act as much more potent suppressors of IL-2-dependent processes in vivo in the vicinity of a tumour.	Gangliosides	52-64	interleukin 2	Mus musculus	109-113
8595265-3	1995	In normal CBA/J mouse muscle (control) the main immunohistochemically detected ganglioside was GM3(Neu5Ac) followed by moderately expressed GM3(Neu5Gc) and GM1.	Gangliosides	79-90	granulocyte macrophage antigen 3	Mus musculus	95-98
7487055-0	1995	Analysis of melanoma cells stably transfected with beta 1,4GalNAc transferase (GM2/GD2 synthase) cDNA: relative glycosyltransferase levels play a dominant role in determining ganglioside expression.	Gangliosides	175-186	beta-1,4-N-acetyl-galactosaminyltransferase 1	Homo sapiens	79-95
7583534-7	1995	An increase in the content of gangliosides GD3 and GD1a was detected in the media underlying atherosclerotic lesions.	Gangliosides	30-42	GRDX	Homo sapiens	43-46
7558412-3	1995	Melanoma ganglioside 9-O-acetyl GD3 is another candidate for ganglioside vaccine construction because of its limited expression in normal human tissues.	Gangliosides	9-20	GRDX	Homo sapiens	32-35
8573994-13	1995	Due to its capacity to bind certain types of gangliosides, SGP-1 appears to act as glycolipid transfer between Sertoli cells and the developing spermatids.	Gangliosides	45-57	prosaposin	Rattus norvegicus	59-64
7558412-3	1995	Melanoma ganglioside 9-O-acetyl GD3 is another candidate for ganglioside vaccine construction because of its limited expression in normal human tissues.	Gangliosides	61-72	GRDX	Homo sapiens	32-35
7560451-0	1995	Differential cell- and immuno-biological properties of murine B16-F1 and F10 melanomas: oncogene c-fos expression, sensitivity to LAK cells and/or IL-2, and components of gangliosides.	Gangliosides	171-183	coagulation factor X	Mus musculus	55-76
8866672-5	1995	This plasmalogen-selective phospholipase A2 is also inhibited by gangliosides and sialoglycoproteins.	Gangliosides	65-77	LOC104974671	Bos taurus	27-43
8563144-0	1995	Detection in human blood platelets of sialyl Lewis X gangliosides, potential ligands for CD62 and other selectins.	Gangliosides	53-65	selectin P	Homo sapiens	89-93
7673410-10	1995	Ganglioside profiles were invariant with respect to treatment of fibroblasts with interferon-gamma.	Gangliosides	0-11	interferon gamma	Homo sapiens	82-98
7620368-1	1995	To investigate the modulated proliferation of an interleukin-3(IL-3)-dependent cell by exogenous ganglioside GM3, mouse bone marrow-derived mast cells (BMMC) were cultured with various concentrations of GM3 in the presence of IL-3.	Gangliosides	97-108	interleukin 3	Mus musculus	63-67
7547879-10	1995	We conclude that alteration of ganglioside composition, particularly the expression of GD3 and O-acetylated GD3, may be associated with the morphological changes observed in this cell line.	Gangliosides	31-42	GRDX	Homo sapiens	87-111
7560451-2	1995	Studies focused on the expression of proto-oncogene c-fos, sensitivities to LAK cells and/or IL-2, and modulation of the expression of ganglioside components after treatment with IL-2.	Gangliosides	135-146	interleukin 2	Mus musculus	179-183
7560451-6	1995	A major component of gangliosides of both F1 and F10 melanomas was GM3.	Gangliosides	21-33	coagulation factor X	Mus musculus	42-52
7560451-6	1995	A major component of gangliosides of both F1 and F10 melanomas was GM3.	Gangliosides	21-33	granulocyte macrophage antigen 3	Mus musculus	67-70
7560451-7	1995	Production of GM3 in F10 melanomas treated with IL-2 for 4 days increased, and, if the treatment was continued for 7 days, minor components of gangliosides, such as GM2, GM1, and GD1a, appeared only in F1 melanomas, while the increase of production of GM3 disappeared in both melanomas.	Gangliosides	143-155	cytochrome b5 domain containing 2	Mus musculus	165-168
7636307-0	1995	Ganglioside GT1b inhibits keratinocyte adhesion and migration on a fibronectin matrix.	Gangliosides	0-11	fibronectin 1	Homo sapiens	67-78
7595635-0	1995	Ganglioside characterization of a cell line displaying motor neuron-like phenotype: GM2 as a possible major ganglioside in motor neurons.	Gangliosides	0-11	cytochrome b5 domain containing 2	Mus musculus	84-87
7595635-0	1995	Ganglioside characterization of a cell line displaying motor neuron-like phenotype: GM2 as a possible major ganglioside in motor neurons.	Gangliosides	108-119	cytochrome b5 domain containing 2	Mus musculus	84-87
7595635-3	1995	GM2, which is only a minor ganglioside component of CNS, was the major component in NSC-34 occupying almost 75% of total gangliosides, whereas GD1a and GM3 were major species in the parental N18TG2, which had only 8.5% GM2.	Gangliosides	27-38	cytochrome b5 domain containing 2	Mus musculus	0-3
7595635-3	1995	GM2, which is only a minor ganglioside component of CNS, was the major component in NSC-34 occupying almost 75% of total gangliosides, whereas GD1a and GM3 were major species in the parental N18TG2, which had only 8.5% GM2.	Gangliosides	121-133	cytochrome b5 domain containing 2	Mus musculus	0-3
7616235-7	1995	The results described indicate identity between HDL and IP and suggest that HDL (particularly apolipoprotein A) could play an important role on ganglioside biosynthesis modulation during CNS development.	Gangliosides	144-155	lipoprotein(a)	Homo sapiens	94-110
7636307-1	1995	Highly sialylated gangliosides have been shown to alter cellular adhesion to a fibronectin matrix.	Gangliosides	18-30	fibronectin 1	Homo sapiens	79-90
7636307-3	1995	Ganglioside GT1b significantly prevented attachment of keratinocytes to fibronectin and also detached previously adherent keratinocytes in a concentration-dependent manner without cell toxicity.	Gangliosides	0-11	fibronectin 1	Homo sapiens	72-83
7473880-4	1995	Stimulation of DNA synthesis by low doses of serum in U-1242 MG cells is inhibited in a dose-responsive fashion by ganglioside GM1.	Gangliosides	115-126	coenzyme Q10A	Mus musculus	127-130
7626605-0	1995	Interleukin-3-associated expression of gangliosides in mouse myelogenous leukemia NFS60 cells introduced with interleukin-3 gene: expression of ganglioside GD1a and key involvement of CMP-NeuAc:lactosylceramide alpha 2-->3-sialyltransferase in GD1a expression.	Gangliosides	39-51	interleukin 3	Mus musculus	0-13
7626605-0	1995	Interleukin-3-associated expression of gangliosides in mouse myelogenous leukemia NFS60 cells introduced with interleukin-3 gene: expression of ganglioside GD1a and key involvement of CMP-NeuAc:lactosylceramide alpha 2-->3-sialyltransferase in GD1a expression.	Gangliosides	39-51	interleukin 3	Mus musculus	110-123
7626605-0	1995	Interleukin-3-associated expression of gangliosides in mouse myelogenous leukemia NFS60 cells introduced with interleukin-3 gene: expression of ganglioside GD1a and key involvement of CMP-NeuAc:lactosylceramide alpha 2-->3-sialyltransferase in GD1a expression.	Gangliosides	39-50	interleukin 3	Mus musculus	0-13
7626605-0	1995	Interleukin-3-associated expression of gangliosides in mouse myelogenous leukemia NFS60 cells introduced with interleukin-3 gene: expression of ganglioside GD1a and key involvement of CMP-NeuAc:lactosylceramide alpha 2-->3-sialyltransferase in GD1a expression.	Gangliosides	39-50	interleukin 3	Mus musculus	110-123
7626605-1	1995	Murine interleukin-3 (IL-3)-associated expression of gangliosides has been investigated using a gene transfection technique.	Gangliosides	53-65	interleukin 3	Mus musculus	7-26
7626605-9	1995	According to these data, the progression of tumor stage by the acquisition of autonomous cell growth ability after IL-3 gene transfection resulted in dramatic changes in cell surface gangliosides and their biosynthetic pathways.	Gangliosides	183-195	interleukin 3	Mus musculus	115-119
7626605-10	1995	GD1a could be considered as an IL-3-associated ganglioside and was expressed in a tight connection with a single glycosyltransferase (GM3 synthase) up-regulation and with IL-3 expression in murine myelogenous leukemia cells.	Gangliosides	47-58	interleukin 3	Mus musculus	31-35
7473880-7	1995	On the other hand, GM1, GD1a, and GT1b stimulate DNA synthesis in quiescent U-1242 MG cells in both sparse and confluent conditions, indicating that ganglioside-stimulated DNA synthesis is dependent on the phase of cellular growth rather than cellular density.	Gangliosides	149-160	coenzyme Q10A	Mus musculus	19-22
7786888-15	1995	Our results suggest that calcium influx is a key element for both DNA-binding activity of AP-1 and cell proliferation induced by binding of the B subunit of cholera toxin to cell surface ganglioside GM1.	Gangliosides	187-198	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	90-94
7483767-4	1995	The chimera protein obtained bound to ganglioside GM1, and had the antigenicity of both cholera toxin B subunit and HBV PreS2 as confirmed by ELISA.	Gangliosides	38-49	coenzyme Q10A	Mus musculus	50-53
7483767-4	1995	The chimera protein obtained bound to ganglioside GM1, and had the antigenicity of both cholera toxin B subunit and HBV PreS2 as confirmed by ELISA.	Gangliosides	38-49	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	88-111
7539142-0	1995	Ganglioside GM1 binds to the Trk protein and regulates receptor function.	Gangliosides	0-11	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	29-32
7779864-8	1995	These results suggest that GM1 or related ganglioside structure(s) may function as natural modulator(s) of the beta 1-adrenergic receptor.	Gangliosides	42-53	adrenoceptor beta 1	Homo sapiens	111-137
7539142-1	1995	Several lines of evidence have suggested that ganglioside GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF), but its precise mechanism is yet to be elucidated.	Gangliosides	46-57	nerve growth factor	Rattus norvegicus	119-138
7539142-1	1995	Several lines of evidence have suggested that ganglioside GM1 stimulates neuronal sprouting and enhances the action of nerve growth factor (NGF), but its precise mechanism is yet to be elucidated.	Gangliosides	46-57	nerve growth factor	Rattus norvegicus	140-143
7536122-0	1995	A phase I study of anti-GD3 ganglioside monoclonal antibody R24 and recombinant human macrophage-colony stimulating factor in patients with metastatic melanoma.	Gangliosides	28-39	GRDX	Homo sapiens	24-27
7558008-0	1995	beta-1,4-N-Acetylgalactosaminyltransferase involved in ganglioside synthesis: cDNA sequence, expression, and chromosome mapping of the mouse gene.	Gangliosides	55-66	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	0-42
7558008-1	1995	beta-1,4-N-Acetylgalactosaminyltransferase (EC 2.4.1.92; GalNAc-T) is a glycosyltransferase involved in the synthesis of gangliosides GM2 and GD2 as well as glycolipid GA2.	Gangliosides	121-133	chondroitin sulfate N-acetylgalactosaminyltransferase 1	Mus musculus	0-42
7558008-1	1995	beta-1,4-N-Acetylgalactosaminyltransferase (EC 2.4.1.92; GalNAc-T) is a glycosyltransferase involved in the synthesis of gangliosides GM2 and GD2 as well as glycolipid GA2.	Gangliosides	121-133	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	57-65
7620904-7	1995	Lectins with the highest degree of binding included cholera toxin B subunit (CTB), which binds primarily to the gangliosides GM1 and GD1b, phaseolus vulgaris erythroagglutinating lectin (PHA-E), which binds to a variety of cell adhesion molecules, and wheat germ agglutinin (WGA).	Gangliosides	112-124	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	77-80
7536957-1	1995	The ganglioside GD3 has a variety of biological functions.	Gangliosides	4-15	GRDX	Homo sapiens	16-19
8586620-5	1995	On the other hand, the other two monoclonal antibodies, MSG-1 and SPS-20, which were generated by immunizing mice with purified ganglioside GM3(NeuGc) and SPG(NeuGc), respectively, showed cross-reactivity to structurally related gangliosides.	Gangliosides	229-241	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Mus musculus	56-61
8586620-6	1995	The MSG-1 monoclonal antibody exhibited reactivity to ganglioside GM3(NeuAc).	Gangliosides	54-65	Cbp/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 1	Mus musculus	4-9
7706785-3	1995	The hybrid protein retained the ganglioside-binding activity of LT-B and was tested in mice for its immunogenicity after local administration.	Gangliosides	32-43	lymphotoxin B	Mus musculus	64-68
7659264-2	1995	In vivo gangliosides (GS) bring about inhibitory effects on the immune response which is attributable to a weakening of the interaction between interleukin-2 (IL-2) and its receptor.	Gangliosides	8-20	interleukin 2	Rattus norvegicus	144-157
7620344-5	1995	GD3 and GM3 were major gangliosides in Bomirski hamster melanoma.	Gangliosides	23-35	GRDX	Homo sapiens	0-3
7620344-6	1995	Alkali-labile O-acetyl-GD3, a melanoma-specific ganglioside, was detected only in Bomirski melanoma.	Gangliosides	48-59	GRDX	Homo sapiens	23-26
7708728-1	1995	Gangliosides, such as GM2, GD2, GD3, and 9-O-acetyl GD3, are receiving attention as targets for antibody-based and vaccine-based therapies of melanoma.	Gangliosides	0-12	GRDX	Homo sapiens	32-35
7708728-1	1995	Gangliosides, such as GM2, GD2, GD3, and 9-O-acetyl GD3, are receiving attention as targets for antibody-based and vaccine-based therapies of melanoma.	Gangliosides	0-12	GRDX	Homo sapiens	52-55
7867710-1	1995	Gangliosides of the "b" pathway of ganglioside synthesis, including GM3, GD3, and GD1b, inhibit the proliferation of cultured keratinocytes without increasing differentiation.	Gangliosides	0-12	GRDX	Homo sapiens	73-76
7867710-1	1995	Gangliosides of the "b" pathway of ganglioside synthesis, including GM3, GD3, and GD1b, inhibit the proliferation of cultured keratinocytes without increasing differentiation.	Gangliosides	35-46	GRDX	Homo sapiens	73-76
7751022-0	1995	Gangliosides interact with interleukin-4 and inhibit interleukin-4-stimulated helper T-cell proliferation.	Gangliosides	0-12	interleukin 4	Mus musculus	27-40
7751022-0	1995	Gangliosides interact with interleukin-4 and inhibit interleukin-4-stimulated helper T-cell proliferation.	Gangliosides	0-12	interleukin 4	Mus musculus	53-66
7751022-2	1995	We have investigated the effect of gangliosides on interleukin-4 (IL-4)-mediated processes in the murine helper T-cell line HT-2.	Gangliosides	35-47	interleukin 4	Mus musculus	51-64
7751022-2	1995	We have investigated the effect of gangliosides on interleukin-4 (IL-4)-mediated processes in the murine helper T-cell line HT-2.	Gangliosides	35-47	interleukin 4	Mus musculus	66-70
7751022-3	1995	Various gangliosides inhibited IL-4-stimulated DNA synthesis in HT-2 with IC50 values in the range 26-60 micrograms/ml.	Gangliosides	8-20	interleukin 4	Mus musculus	31-35
7751022-5	1995	Gangliosides were highly effective inhibitors when added to G0-G1-synchronized HT-2 cells during the first 6 hr after IL-4 stimulation, indicating that they act early in the IL-4 signalling pathway.	Gangliosides	0-12	interleukin 4	Mus musculus	118-122
7751022-5	1995	Gangliosides were highly effective inhibitors when added to G0-G1-synchronized HT-2 cells during the first 6 hr after IL-4 stimulation, indicating that they act early in the IL-4 signalling pathway.	Gangliosides	0-12	interleukin 4	Mus musculus	174-178
7751022-6	1995	High levels of exogenous IL-4 completely reversed inhibition of proliferation by gangliosides, which suggests that gangliosides compete with cellular IL-4 receptors for available lymphokine.	Gangliosides	81-93	interleukin 4	Mus musculus	25-29
7751022-6	1995	High levels of exogenous IL-4 completely reversed inhibition of proliferation by gangliosides, which suggests that gangliosides compete with cellular IL-4 receptors for available lymphokine.	Gangliosides	81-93	interleukin 4	Mus musculus	150-154
7751022-6	1995	High levels of exogenous IL-4 completely reversed inhibition of proliferation by gangliosides, which suggests that gangliosides compete with cellular IL-4 receptors for available lymphokine.	Gangliosides	115-127	interleukin 4	Mus musculus	25-29
7751022-7	1995	Receptor-binding experiments confirmed that gangliosides blocked binding of [125I]IL-4 to receptors on intact HT-2 cells in a dose-dependent fashion.	Gangliosides	44-56	interleukin 4	Mus musculus	82-86
7751022-8	1995	Gel-filtration fast protein liquid chromatography (FPLC) demonstrated that [125I]IL-4 co-eluted with ganglioside micelles after co-incubation before chromatography, and an overlay technique showed that IL-4 bound efficiently to gangliosides on thin-layer chromatography plates.	Gangliosides	101-112	interleukin 4	Mus musculus	81-85
7751022-8	1995	Gel-filtration fast protein liquid chromatography (FPLC) demonstrated that [125I]IL-4 co-eluted with ganglioside micelles after co-incubation before chromatography, and an overlay technique showed that IL-4 bound efficiently to gangliosides on thin-layer chromatography plates.	Gangliosides	228-240	interleukin 4	Mus musculus	202-206
7751022-9	1995	Taken together, these results indicate that gangliosides act as potent suppressors of IL-4-dependent processes in lymphocytes, and that their mechanism of action involves direct interaction with IL-4, thus preventing IL-4 binding to high-affinity IL-4 receptors.	Gangliosides	44-56	interleukin 4	Mus musculus	86-90
7751022-9	1995	Taken together, these results indicate that gangliosides act as potent suppressors of IL-4-dependent processes in lymphocytes, and that their mechanism of action involves direct interaction with IL-4, thus preventing IL-4 binding to high-affinity IL-4 receptors.	Gangliosides	44-56	interleukin 4	Mus musculus	195-199
7751022-9	1995	Taken together, these results indicate that gangliosides act as potent suppressors of IL-4-dependent processes in lymphocytes, and that their mechanism of action involves direct interaction with IL-4, thus preventing IL-4 binding to high-affinity IL-4 receptors.	Gangliosides	44-56	interleukin 4	Mus musculus	195-199
7751022-9	1995	Taken together, these results indicate that gangliosides act as potent suppressors of IL-4-dependent processes in lymphocytes, and that their mechanism of action involves direct interaction with IL-4, thus preventing IL-4 binding to high-affinity IL-4 receptors.	Gangliosides	44-56	interleukin 4	Mus musculus	195-199
7659264-2	1995	In vivo gangliosides (GS) bring about inhibitory effects on the immune response which is attributable to a weakening of the interaction between interleukin-2 (IL-2) and its receptor.	Gangliosides	8-20	interleukin 2	Rattus norvegicus	159-163
7873593-2	1995	CT-B association with pyrene-GM1 micelles induces changes in the fluorescence properties of this ganglioside analogue that are consistent with its conversion from an excimer to a monomer form.	Gangliosides	97-108	phosphate cytidylyltransferase 1B, choline	Homo sapiens	0-4
7667829-5	1995	Both gangliosides and cell surface proteins with carboxy-terminal lysyl residues, including enolase, a candidate plasminogen receptor, inhibited Lp(a) binding to U937 cells.	Gangliosides	5-17	lipoprotein(a)	Homo sapiens	145-150
7749720-0	1995	Adhesion of human glioma cell lines to fibronectin, laminin, vitronectin and collagen I is modulated by gangliosides in vitro.	Gangliosides	104-116	fibronectin 1	Homo sapiens	39-50
7766021-5	1995	Homoloyg search and limited proteolytic digestion showed that the enzyme has a C-terminal 58-kDa catalytic domain very similar to that of human lysosomal beta-hexosaminidase that is responsible for hydrolyzing gangliosides.	Gangliosides	210-222	O-GlcNAcase	Homo sapiens	154-173
7749720-0	1995	Adhesion of human glioma cell lines to fibronectin, laminin, vitronectin and collagen I is modulated by gangliosides in vitro.	Gangliosides	104-116	vitronectin	Homo sapiens	61-72
7608118-0	1995	Interleukin 4 enhances ganglioside GD3 expression on the human fibroblast cell line WI-38.	Gangliosides	23-34	interleukin 4	Homo sapiens	0-13
7608118-0	1995	Interleukin 4 enhances ganglioside GD3 expression on the human fibroblast cell line WI-38.	Gangliosides	23-34	GRDX	Homo sapiens	35-38
8549425-0	1995	Ganglioside markers GD3, GD2, and A2B5 in fetal human neurons and glial cells in culture.	Gangliosides	0-11	GRDX	Homo sapiens	20-23
7722094-3	1995	Ganglioside analysis of a metastatic tumor demonstrated that it expressed GM3, GM2, GD3, GD2, and polysialogangliosides.	Gangliosides	0-11	GRDX	Homo sapiens	84-87
7599539-5	1995	Of various substrates tested, the ganglioside-stimulated cAMP-kinase could phosphorylate microtubule-associated protein 2, synapsin I and myelin basic protein, but not histone H1 and casein.	Gangliosides	34-45	synapsin I	Rattus norvegicus	123-133
7599539-5	1995	Of various substrates tested, the ganglioside-stimulated cAMP-kinase could phosphorylate microtubule-associated protein 2, synapsin I and myelin basic protein, but not histone H1 and casein.	Gangliosides	34-45	myelin basic protein	Rattus norvegicus	138-158
7762760-1	1995	Compared with DMD cases and non-neuromuscular disease controls, FCMD cases showed a reduction of total gangliosides, and an abnormal, immature ganglioside pattern in the cerebral gray and white matter.	Gangliosides	103-115	fukutin	Homo sapiens	64-68
7762760-1	1995	Compared with DMD cases and non-neuromuscular disease controls, FCMD cases showed a reduction of total gangliosides, and an abnormal, immature ganglioside pattern in the cerebral gray and white matter.	Gangliosides	103-114	fukutin	Homo sapiens	64-68
7863261-1	1995	Gangliosides modulate the expression of CD4 molecules on the cell surface of T lymphocytes.	Gangliosides	0-12	CD4 molecule	Homo sapiens	40-43
7863261-3	1995	The CD4 down-modulation was ganglioside-dose dependent and was already evident after 5 min of treatment, reaching the maximum after 20 min.	Gangliosides	28-39	CD4 molecule	Homo sapiens	4-7
7741518-3	1995	The cell-associated virus determined by sialidase activity was also reduced by F36 treatment at 0 or 2 h. F36 also inhibited the fusion of A/PR8 with liposomes containing bovine brain mixed gangliosides at pH 5.0.	Gangliosides	190-202	f36	Drosophila melanogaster	79-82
7741518-3	1995	The cell-associated virus determined by sialidase activity was also reduced by F36 treatment at 0 or 2 h. F36 also inhibited the fusion of A/PR8 with liposomes containing bovine brain mixed gangliosides at pH 5.0.	Gangliosides	190-202	f36	Drosophila melanogaster	106-109
8549425-1	1995	Expression of ganglioside markers GD3, GD2, and A2B5 was investigated in primary cell cultures isolated from fetal human brains of 12-15 weeks" gestation by immunocytochemistry.	Gangliosides	14-25	GRDX	Homo sapiens	34-37
7798945-7	1995	These findings are consistent with the hypothesis that Neuro2a cells contain a sialidase (likely of lysosomal nature) affecting ganglioside GM1 and GM2.	Gangliosides	128-139	coenzyme Q10A	Mus musculus	140-143
7534259-4	1995	By recruiting the necessary T-cell help found in the T-cell memory compartment against TT, primary immune responses were obtained against the hapten dinitrophenyl (DNP), the V3 loop peptide derived from glycoprotein (gp120) (HIV-1), the melanoma-associated GD2 ganglioside and ovine submaxillary mucin.	Gangliosides	261-272	Envelope surface glycoprotein gp160, precursor	Human immunodeficiency virus 1	217-222
7843249-0	1995	Differential effects of gangliosides on human IgE and IgG4 production.	Gangliosides	24-36	immunoglobulin heavy constant epsilon	Homo sapiens	46-49
7843249-2	1995	Of the various gangliosides tested, only GM2 and GM3 inhibited the IgE and IgG4 production induced by interleukin (IL)-4 plus hydrocortisone (HC), or that induced by IL-13 plus HC, in human surface IgE- and IgG4-negative (sIgE-, sIgG4-) B cells without affecting the production of IgG1, IgG2, IgG3, IgM, IgA1 or IgA2.	Gangliosides	15-27	immunoglobulin heavy constant epsilon	Homo sapiens	67-70
7798945-0	1995	The degradative pathway of gangliosides GM1 and GM2 in Neuro2a cells by sialidase.	Gangliosides	27-39	coenzyme Q10A	Mus musculus	40-43
7798945-1	1995	Gangliosides GM1 [3H-labeled at the sphingosine (Sph) moiety] and GM2 [3H-labeled at the Sph or N-acetylgalactosamine (GalNAc) moiety] were administered to cultured Neuro2a cells for varying pulse (1-4 h) and chase (up to 4 h) periods, and their metabolic processing was followed.	Gangliosides	0-12	coenzyme Q10A	Mus musculus	13-16
7623611-0	1995	Gangliosides raise the intracellular Ca2+ level in different cell types.	Gangliosides	0-12	carbonic anhydrase 2	Rattus norvegicus	37-40
21043587-6	1995	It is concluded that gangliosides incorporated into platelet membranes influence the number of 5-HT binding sites on the serotonin transporter.	Gangliosides	21-33	solute carrier family 6 member 4	Homo sapiens	121-142
7623611-1	1995	Total gangliosides from bovine brain at micromolar concentration induce intracellular Ca2+ increments in a temperature, time and dose dependent manner when assayed with suspensions of rat macrophages, rat and chicken neurons, human erythrocytes and liposomes, loaded with the fluorescent Ca2+ indicator FURA 2.	Gangliosides	6-18	carbonic anhydrase 2	Bos taurus	86-89
7623611-1	1995	Total gangliosides from bovine brain at micromolar concentration induce intracellular Ca2+ increments in a temperature, time and dose dependent manner when assayed with suspensions of rat macrophages, rat and chicken neurons, human erythrocytes and liposomes, loaded with the fluorescent Ca2+ indicator FURA 2.	Gangliosides	6-18	carbonic anhydrase 2	Homo sapiens	288-291
7623611-7	1995	The results also suggest the possibility that the well-known neurotrophic effect produced by gangliosides on undifferentiated neurons in culture may be due to subtoxic cytosolic Ca2+ increments.	Gangliosides	93-105	carbonic anhydrase 2	Rattus norvegicus	178-181
7888037-2	1994	Murine studies suggest that the antibody response to membrane-bound cryptic antigens, such as phospholipids and gangliosides, can be induced and augmented by attaching lipid A to membranes.	Gangliosides	112-124	cripto, FRL-1, cryptic family 1	Mus musculus	68-75
7713516-1	1994	The GM2 activator protein forms a substrate-complex with GM2 ganglioside, which enables degradation of the ganglioside by beta-hexosaminidase A. Mutations in the human GM2 activator protein gene (GM2A) result in the GM2 gangliosidosis AB variant, a severe neurological disease.	Gangliosides	61-72	cytochrome b5 domain containing 2	Mus musculus	4-7
7713516-1	1994	The GM2 activator protein forms a substrate-complex with GM2 ganglioside, which enables degradation of the ganglioside by beta-hexosaminidase A. Mutations in the human GM2 activator protein gene (GM2A) result in the GM2 gangliosidosis AB variant, a severe neurological disease.	Gangliosides	61-72	cytochrome b5 domain containing 2	Mus musculus	57-60
7713516-1	1994	The GM2 activator protein forms a substrate-complex with GM2 ganglioside, which enables degradation of the ganglioside by beta-hexosaminidase A. Mutations in the human GM2 activator protein gene (GM2A) result in the GM2 gangliosidosis AB variant, a severe neurological disease.	Gangliosides	61-72	cytochrome b5 domain containing 2	Mus musculus	57-60
7713516-1	1994	The GM2 activator protein forms a substrate-complex with GM2 ganglioside, which enables degradation of the ganglioside by beta-hexosaminidase A. Mutations in the human GM2 activator protein gene (GM2A) result in the GM2 gangliosidosis AB variant, a severe neurological disease.	Gangliosides	61-72	ganglioside GM2 activator	Homo sapiens	196-200
7713516-1	1994	The GM2 activator protein forms a substrate-complex with GM2 ganglioside, which enables degradation of the ganglioside by beta-hexosaminidase A. Mutations in the human GM2 activator protein gene (GM2A) result in the GM2 gangliosidosis AB variant, a severe neurological disease.	Gangliosides	61-72	cytochrome b5 domain containing 2	Mus musculus	57-60
7734842-12	1994	Identification of this unique ganglioside intimately associated with the TSH receptor implies that it has an integral role in receptor structure and function.	Gangliosides	30-41	thyroid stimulating hormone receptor	Rattus norvegicus	73-85
7850027-5	1994	In this study immunofluorescence flow cytometry shows that cholera toxin beta subunit (CT beta), which binds to the ganglioside GM1, induces a twofold increase in the number of DEV cells differentiating towards a neuronal pathway, as shown by the increased proportion and labelling intensity of cells stained by an anti-neurofilament antibody.	Gangliosides	116-127	phosphate cytidylyltransferase 1B, choline	Homo sapiens	87-94
7991134-0	1994	Acute ataxic neuropathy with cross-reactive antibodies to GD1b and GD3 gangliosides.	Gangliosides	71-83	GRDX	Homo sapiens	67-70
7743601-0	1994	Inhibition of LPS-mediated cell activation in vitro and in vivo by gangliosides.	Gangliosides	67-79	toll-like receptor 4	Mus musculus	14-17
7743601-2	1994	Addition of gangliosides to B cells as late as 120 min after the addition of LPS still inhibited B-cell proliferation, suggesting that inhibition did not simply reflect direct binding of LPS to gangliosides.	Gangliosides	12-24	toll-like receptor 4	Mus musculus	77-80
7743601-2	1994	Addition of gangliosides to B cells as late as 120 min after the addition of LPS still inhibited B-cell proliferation, suggesting that inhibition did not simply reflect direct binding of LPS to gangliosides.	Gangliosides	12-24	toll-like receptor 4	Mus musculus	187-190
7743601-5	1994	The inhibitory effect of gangliosides was not restricted to B cells, since LPS-induced TNF production by macrophages was also inhibited in vitro.	Gangliosides	25-37	toll-like receptor 4	Mus musculus	75-78
7743601-5	1994	The inhibitory effect of gangliosides was not restricted to B cells, since LPS-induced TNF production by macrophages was also inhibited in vitro.	Gangliosides	25-37	tumor necrosis factor	Mus musculus	87-90
7743601-6	1994	The inhibitory activity of gangliosides was also seen in vivo, and mice injected with soluble gangliosides or implanted with slow-release pellets impregnated with gangliosides showed reduced TNF production in vivo in response to LPS.	Gangliosides	27-39	tumor necrosis factor	Mus musculus	191-194
7743601-6	1994	The inhibitory activity of gangliosides was also seen in vivo, and mice injected with soluble gangliosides or implanted with slow-release pellets impregnated with gangliosides showed reduced TNF production in vivo in response to LPS.	Gangliosides	27-39	toll-like receptor 4	Mus musculus	229-232
7743601-6	1994	The inhibitory activity of gangliosides was also seen in vivo, and mice injected with soluble gangliosides or implanted with slow-release pellets impregnated with gangliosides showed reduced TNF production in vivo in response to LPS.	Gangliosides	94-106	tumor necrosis factor	Mus musculus	191-194
7743601-6	1994	The inhibitory activity of gangliosides was also seen in vivo, and mice injected with soluble gangliosides or implanted with slow-release pellets impregnated with gangliosides showed reduced TNF production in vivo in response to LPS.	Gangliosides	94-106	toll-like receptor 4	Mus musculus	229-232
7743601-6	1994	The inhibitory activity of gangliosides was also seen in vivo, and mice injected with soluble gangliosides or implanted with slow-release pellets impregnated with gangliosides showed reduced TNF production in vivo in response to LPS.	Gangliosides	94-106	tumor necrosis factor	Mus musculus	191-194
7743601-6	1994	The inhibitory activity of gangliosides was also seen in vivo, and mice injected with soluble gangliosides or implanted with slow-release pellets impregnated with gangliosides showed reduced TNF production in vivo in response to LPS.	Gangliosides	94-106	toll-like receptor 4	Mus musculus	229-232
7743601-9	1994	It is likely that this protective effect reflects the ability of gangliosides to suppress LPS-mediated TNF production.	Gangliosides	65-77	toll-like receptor 4	Mus musculus	90-93
7743601-9	1994	It is likely that this protective effect reflects the ability of gangliosides to suppress LPS-mediated TNF production.	Gangliosides	65-77	tumor necrosis factor	Mus musculus	103-106
7706405-7	1994	Transfected cells that expressed a mouse vimentin network demonstrated a twofold or greater increase in the rate of biosynthesis of neutral glycosphingolipids and gangliosides.	Gangliosides	163-175	vimentin	Mus musculus	41-49
7872684-1	1994	With the aim of investigating the passive immunotherapy of brain tumors, we examined the binding of a mouse/human chimeric anti-ganglioside GM2 antibody KM966 to various organs and brain tumors.	Gangliosides	128-139	cytochrome b5 domain containing 2	Mus musculus	140-143
7931336-8	1994	The ganglioside pattern showed continuous change with aging, with decreasing proportions of GM1 and GD1a and increasing proportions of GD1b, GM3, and GD3.	Gangliosides	4-15	GRDX	Homo sapiens	150-153
7926015-2	1994	Here we determined biosynthetic pathways for the ganglioside by detailed measurements of glycosyltransferase activities.	Gangliosides	49-60	protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) L homeolog	Xenopus laevis	89-108
7926020-0	1994	Ganglioside antigen of DU-PAN-2 in a human pancreatic cancer.	Gangliosides	0-11	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	26-31
7926020-1	1994	DU-PAN-2 reactive gangliosides were isolated from the tumor of a patient with pancreatic cancer (duct cell carcinoma, moderately differentiated adenocarcinoma), having a negative Lewis blood phenotype, and were analyzed by means of TLC-immunostaining, enzyme-linked immunosorbent assay (ELISA), permethylation study, 1H NMR spectroscopy and fast atom bombardment mass spectrometry.	Gangliosides	18-30	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	3-8
7926020-3	1994	By TLC-immunostaining and ELISA with chemically synthesized gangliosides, DU-PAN-2 was demonstrated to react strongly with IV3 alpha NeuAc-Lc4Cer, weakly with IV3 alpha NeuAc-nLc4Cer, and moderately with IV6 alpha NeuAc-Lc4Cer and IV6 alpha NeuAc-nLc4Cer.	Gangliosides	60-72	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	77-82
7926020-4	1994	Thus it was concluded that the DU-PAN-2 reactive ganglioside in the tumor is IV3 alpha NeuAc-Lc4Cer and that DU-PAN-2 has a rather broad specificity.	Gangliosides	49-60	poly(A) specific ribonuclease subunit PAN2	Homo sapiens	34-39
8033972-1	1994	Murine B16 melanoma expresses the ganglioside GM3.	Gangliosides	34-45	l(3)87Eb	Drosophila melanogaster	7-10
7820065-0	1994	Ganglioside GM1 reduces ethanol induced phospholipase A2 activity in synaptosomal preparations from mice.	Gangliosides	0-11	phospholipase A2, group IB, pancreas	Mus musculus	40-56
7739148-1	1994	A human Hanganutziu-Deicher (HD) antibody and a chicken anti-N-glycolyneuroaminyllactosylceramide (HD3) antibody were compared in their reaction against HD antigen-active ganglioside (HD3) and a glycoprotein (GP) by radioimmunoassay (RIA).	Gangliosides	171-182	histone deacetylase 3	Homo sapiens	99-102
7858413-5	1994	However, minor components of the gangliosides such as GM2 and GM1 emerged only in BL-6-beta m melanomas after treatment with IL-2.	Gangliosides	33-45	interleukin 2	Mus musculus	125-129
7819413-0	1994	[Lipoxygenase oxidation of arachidonic acid in murine splenocytes and its modulation by the lactone ganglioside GM3].	Gangliosides	100-111	granulocyte macrophage antigen 3	Mus musculus	112-115
7819150-8	1994	This and the restricted expression of O-acetyl GD3 suggest a functional role for this ganglioside in T cell subpopulations.	Gangliosides	86-97	GRDX	Homo sapiens	47-50
7952130-3	1994	Furthermore, base-line separation of alpha 2-3 and alpha 2-6 sialylated neolacto-series gangliosides e.g. IV3Neu5Ac-nLcOse4Cer and IV6Neu5Ac-nLcOse4Cer, isolated from human granulocytes, was achieved and pure fractions of each ganglioside were obtained.	Gangliosides	88-99	immunoglobulin binding protein 1	Homo sapiens	51-60
8033972-1	1994	Murine B16 melanoma expresses the ganglioside GM3.	Gangliosides	34-45	granulocyte macrophage antigen 3	Mus musculus	46-49
8033972-3	1994	Reduction or elimination of the shed GM3 could be therapeutic, and the anti-GM3 antibodies may reduce and clear the shed ganglioside.	Gangliosides	121-132	granulocyte macrophage antigen 3	Mus musculus	76-79
8033972-8	1994	Non-immunized mice or mice immunized with B16 cells alone or ganglioside GM3 alone (without MPL) elicited poor anti-GM3 IgM response, confirming the GM3"s immunologic crypticity and MPL"s immunopotentiating effect.	Gangliosides	61-72	granulocyte macrophage antigen 3	Mus musculus	73-76
7528204-0	1994	Expression of gangliosides GM3 (NeuAc) and GM3 (NeuGc) in myelomas and hybridomas of mouse, rat, and human origin.	Gangliosides	14-26	granulocyte macrophage antigen 3	Mus musculus	27-30
8180204-1	1994	The cDNAs encoding two kinds of Gal beta 1,3GalNAc alpha 2,3-sialytransferases (ST3GalA.1 and ST3GalA.2) have been cloned from mouse brain, both of which could synthesize the NeuAc alpha 2,3Gal beta 1,-3GalNAc sequence of gangliosides as well as O-glycosidically linked oligosaccharides of glycoproteins [Lee et al.	Gangliosides	222-234	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	80-89
8180204-1	1994	The cDNAs encoding two kinds of Gal beta 1,3GalNAc alpha 2,3-sialytransferases (ST3GalA.1 and ST3GalA.2) have been cloned from mouse brain, both of which could synthesize the NeuAc alpha 2,3Gal beta 1,-3GalNAc sequence of gangliosides as well as O-glycosidically linked oligosaccharides of glycoproteins [Lee et al.	Gangliosides	222-234	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	94-103
8180204-12	1994	These results strongly indicate that acceptor preference of ST3GalA.1 is different from that of ST3GalA.2, although their acceptor substrate specificities are the same; i.e., gangliosides serve as predominant acceptors for the latter over O-glycosidically linked oligosaccharides of glycoproteins, which are much better acceptors for the former.	Gangliosides	175-187	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	Mus musculus	60-69
8180204-12	1994	These results strongly indicate that acceptor preference of ST3GalA.1 is different from that of ST3GalA.2, although their acceptor substrate specificities are the same; i.e., gangliosides serve as predominant acceptors for the latter over O-glycosidically linked oligosaccharides of glycoproteins, which are much better acceptors for the former.	Gangliosides	175-187	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Mus musculus	96-105
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	CD2 molecule	Homo sapiens	173-176
8179322-4	1994	The structural characterization of the carbohydrate moieties of G-1, G-2, and G-3 involved glycosyl composition analysis, methylation studies, sequential exoglycosidase hydrolysis, and one-dimensional 1H NMR spectroscopy of the native gangliosides.	Gangliosides	235-247	proline rich protein BstNI subfamily 3	Homo sapiens	64-81
8179322-6	1994	The structures are as follows: [formula: see text] Gangliosides such as G-1, G-2, and G-3, with branched oligosaccharide chains comprising a number of N-acetyllactosamine (Gal-GlcNAc) moieties, are abundant in erythrocytes from various mammalian species.	Gangliosides	51-63	proline rich protein BstNI subfamily 3	Homo sapiens	72-89
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	CD4 molecule	Homo sapiens	183-186
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	CD5 molecule	Homo sapiens	188-191
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	CD8a molecule	Homo sapiens	196-199
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	interleukin 1 beta	Homo sapiens	232-250
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	interleukin 1 beta	Homo sapiens	252-261
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	tumor necrosis factor	Homo sapiens	264-291
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	tumor necrosis factor	Homo sapiens	293-302
8162613-2	1994	Total melanoma gangliosides in micelles inhibited proliferation of peripheral blood mononuclear cells stimulated by various mitogens, modulated lymphocyte surface molecules CD2, CD3, CD4, CD5 and CD8 and inhibited the production of interleukin-1 beta (IL-1 beta), tumor necrosis factor alpha (TNF alpha) and IL-6 by stimulated adherent cells.	Gangliosides	15-27	interleukin 6	Homo sapiens	308-312
8181530-1	1994	The ganglioside GD3 has been described as a membrane component of human T cells which is involved in T cell growth.	Gangliosides	4-15	GRDX	Homo sapiens	16-19
8158143-4	1994	The GT3-synthase reaction with fish brain membranes produced radiolabeled GM3, GD3, and a ganglioside that was identified as GT3 based on mobility on TLC using two different solvent systems.	Gangliosides	90-101	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3	Rattus norvegicus	4-16
8166664-5	1994	Gangliosides, especially the GM3 ganglioside, but not other glycosphingolipids, inhibited the activity of the 39 kDa phospholipase A2 in a dose-dependent manner.	Gangliosides	0-12	LOC104974671	Bos taurus	117-133
8182939-1	1994	The presence of tumor-associated GD3 in the plasma of 12 patients with T-cell acute lymphoblastic leukemia (T-ALL) was determined utilizing microscale ganglioside isolation and thin layer chromatography (TLC) immunodetection with an anti-GD3 monoclonal antibody, R24.	Gangliosides	151-162	GRDX	Homo sapiens	33-36
8110807-7	1994	At temperatures above the bilayer phase transition, gangliosides stimulated the activity of PLA2.	Gangliosides	52-64	phospholipase A2 group IIA	Homo sapiens	92-96
8145051-4	1994	CDw60 monoclonal antibodies (mAb) recognize the 9-O-acetylated disialosyl group on ganglioside GD3 expressed on 20-40% of CD8+ cells.	Gangliosides	83-94	CD8a molecule	Homo sapiens	122-125
8164837-3	1994	These results suggest that semisynthetic ganglioside derivatives may be superior to the parent GM1 ganglioside for human clinical use.	Gangliosides	41-52	coenzyme Q10A	Mus musculus	95-98
7923401-0	1994	Evidence for direct binding of intracellularly distributed ganglioside GM2 to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts.	Gangliosides	59-70	vimentin	Homo sapiens	87-95
7923401-2	1994	In this report we demonstrated that the intracellularly distributed ganglioside GM2 directly binds to isolated vimentin intermediate filaments in normal and Tay-Sachs disease human fibroblasts.	Gangliosides	68-79	vimentin	Homo sapiens	111-119
7923401-10	1994	These results clearly indicated that ganglioside GM2 directly binds to vimentin.	Gangliosides	37-48	vimentin	Homo sapiens	71-79
7920864-1	1994	Most of the semisynthetic ganglioside and sphingosine derivatives studied here decreased the rate as well as the extent of hydrolysis of monomolecular layers of dilauroylphosphorylcholine (dlPC) by both phospholipase A2 (PLA2) and C (PLC).	Gangliosides	26-37	phospholipase A2 group IB	Homo sapiens	203-219
7920864-1	1994	Most of the semisynthetic ganglioside and sphingosine derivatives studied here decreased the rate as well as the extent of hydrolysis of monomolecular layers of dilauroylphosphorylcholine (dlPC) by both phospholipase A2 (PLA2) and C (PLC).	Gangliosides	26-37	phospholipase A2 group IB	Homo sapiens	221-225
7920864-1	1994	Most of the semisynthetic ganglioside and sphingosine derivatives studied here decreased the rate as well as the extent of hydrolysis of monomolecular layers of dilauroylphosphorylcholine (dlPC) by both phospholipase A2 (PLA2) and C (PLC).	Gangliosides	26-37	heparan sulfate proteoglycan 2	Homo sapiens	234-237
8110807-0	1994	Regulation by gangliosides and sulfatides of phospholipase A2 activity against dipalmitoyl- and dilauroylphosphatidylcholine in small unilamellar bilayer vesicles and mixed monolayers.	Gangliosides	14-26	phospholipase A2 group IB	Homo sapiens	45-61
8110807-1	1994	The modulation by gangliosides GM1 and GD1a, and sulfatide (Sulf) of the activity of porcine pancreatic phospholipase A2 was studied with small unilamellar vesicles of dipalmitoylphosphatidylcholine (L-dpPC) and lipid monolayers of dilauroylphosphatidylcholine (L-dlPC).	Gangliosides	18-30	phospholipase A2 group IB	Homo sapiens	104-120
8110807-11	1994	Our results indicate that Sulf and gangliosides modulate the catalytic activity of PLA2 at the interface itself, beyond the initial steps of enzyme adsorption and activation, probably through modifications of the intermolecular organization and surface electrostatics of the phospholipid substrate.	Gangliosides	35-47	phospholipase A2 group IIA	Homo sapiens	83-87
7511336-10	1994	In contrast, cells expressing the delta F508 CFTR have significantly decreased amounts of sialylated glycoproteins and gangliosides on the cell surface.	Gangliosides	119-131	CF transmembrane conductance regulator	Homo sapiens	45-49
8106508-0	1994	Src family tyrosine kinase p53/56lyn, a serine kinase and Fc epsilon RI associate with alpha-galactosyl derivatives of ganglioside GD1b in rat basophilic leukemia RBL-2H3 cells.	Gangliosides	119-130	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	27-30
8106508-9	1994	The same 71-80-kDa tyrosine-phosphorylated proteins were immunoprecipitated by mAb AA4 and anti-Lyn antibodies and may play a role in the interaction of p53/56lyn with the gangliosides.	Gangliosides	172-184	LYN proto-oncogene, Src family tyrosine kinase	Rattus norvegicus	96-99
8106508-9	1994	The same 71-80-kDa tyrosine-phosphorylated proteins were immunoprecipitated by mAb AA4 and anti-Lyn antibodies and may play a role in the interaction of p53/56lyn with the gangliosides.	Gangliosides	172-184	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	153-156
8106508-11	1994	These complexes of gangliosides and several proteins that include p53/56lyn, a serine kinase, and the high affinity IgE receptor could play an important role in receptor-mediated signal transduction.	Gangliosides	19-31	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	66-69
8283032-0	1994	Increased proliferation, cytotoxicity, and gene expression after stimulation of human peripheral blood T lymphocytes through a surface ganglioside (GD3) Previous studies have suggested that gangliosides have an important role in cell signaling and recognition.	Gangliosides	135-146	GRDX	Homo sapiens	148-151
8118871-1	1994	T cells made CD4- by ganglioside (GM1) treatment were cultured in antisense oligodeoxynucleotides complementary to mRNA for CD4.	Gangliosides	21-32	CD4 molecule	Homo sapiens	13-16
7507893-7	1994	Purified p75 retained its ability to bind to ganglioside GT1b, the receptor for tetanus toxin, and to be recognized by protective and neutralizing anti-pertussis toxin antibodies specific for conformational epitopes.	Gangliosides	45-56	tumor necrosis factor receptor superfamily, member 1b	Mus musculus	9-12
8086038-3	1994	Although GM3-NeuAc was the major ganglioside in both the solid tumor and cultured tumor cells, several gangliosides expressed in the solid tumors (e.g., GM2-NeuGc, GM1, and GM1b) were not expressed in the cultured tumor cells.	Gangliosides	103-115	cytochrome b5 domain containing 2	Mus musculus	153-156
8086038-8	1994	Radiolabeling of the cultured tumor cell gangliosides with [14C]galactose revealed that GM3-NeuAc was the only ganglioside synthesized by the tumor cells.	Gangliosides	41-53	granulocyte macrophage antigen 3	Mus musculus	88-91
8086038-8	1994	Radiolabeling of the cultured tumor cell gangliosides with [14C]galactose revealed that GM3-NeuAc was the only ganglioside synthesized by the tumor cells.	Gangliosides	41-52	granulocyte macrophage antigen 3	Mus musculus	88-91
8086040-5	1994	GD3, a dominant ganglioside on malignant melanoma, was modified by ozone cleavage of the double bond in the ceramide backbone, an aldehyde group introduced and used for coupling via reductive amination to epsilon-amino-lysyl groups of proteins.	Gangliosides	16-27	GRDX	Homo sapiens	0-3
8086043-0	1994	Preferential binding of the epidermal growth factor receptor to ganglioside GM3 coated plates.	Gangliosides	64-75	epidermal growth factor receptor	Homo sapiens	28-60
8086043-1	1994	Ganglioside GM3 has been shown to modulate epidermal growth factor receptor function.	Gangliosides	0-11	epidermal growth factor receptor	Homo sapiens	43-75
8133075-1	1994	Ganglioside GM2, which is one of the major gangliosides expressed on cell surface of neuroectodermal-origin human tumors, has been focused on as a target molecule for passive immunotherapy.	Gangliosides	0-11	cytochrome b5 domain containing 2	Mus musculus	12-15
8133075-1	1994	Ganglioside GM2, which is one of the major gangliosides expressed on cell surface of neuroectodermal-origin human tumors, has been focused on as a target molecule for passive immunotherapy.	Gangliosides	43-55	cytochrome b5 domain containing 2	Mus musculus	12-15
8133075-6	1994	ELISA with 11 common gangliosides revealed that one of the variant, KM750, retained the same binding specificity to N-acetyl GM2 as that of the parental IgM, KM697.	Gangliosides	21-33	cytochrome b5 domain containing 2	Mus musculus	125-128
8283032-0	1994	Increased proliferation, cytotoxicity, and gene expression after stimulation of human peripheral blood T lymphocytes through a surface ganglioside (GD3) Previous studies have suggested that gangliosides have an important role in cell signaling and recognition.	Gangliosides	190-202	GRDX	Homo sapiens	148-151
8283032-2	1994	A mAb, R24, that reacts specifically with a cell surface ganglioside (GD3) has been demonstrated to stimulate proliferation of T cells derived from human peripheral blood.	Gangliosides	57-68	GRDX	Homo sapiens	70-73
8308283-1	1994	We previously reported the expression of a mouse/human chimeric anti-ganglioside GD3 antibody, KM871 (IgG1,kappa) in mouse myeloma SP2/0 cells under the control of the ecotropic Moloney virus long terminal repeat by the co-transfection of chimeric heavy (H) and light (L) chain vectors (Shitara et al.	Gangliosides	69-80	LOC105243590	Mus musculus	102-106
8308283-1	1994	We previously reported the expression of a mouse/human chimeric anti-ganglioside GD3 antibody, KM871 (IgG1,kappa) in mouse myeloma SP2/0 cells under the control of the ecotropic Moloney virus long terminal repeat by the co-transfection of chimeric heavy (H) and light (L) chain vectors (Shitara et al.	Gangliosides	69-80	Sp2 transcription factor	Mus musculus	131-136
8274754-0	1994	Hemorrhagic tumor necrosis during a pilot trial of tumor necrosis factor-alpha and anti-GD3 ganglioside monoclonal antibody in patients with metastatic melanoma.	Gangliosides	92-103	GRDX	Homo sapiens	88-91
7998825-9	1994	The results suggest that ethanol or high carbohydrate ingestion diminishes the activity of GD3 synthase, a key enzyme in the metabolism of gangliosides, which determines the proportion of gangliosides, belonging to the a- and b-series.	Gangliosides	139-151	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	91-103
7998825-9	1994	The results suggest that ethanol or high carbohydrate ingestion diminishes the activity of GD3 synthase, a key enzyme in the metabolism of gangliosides, which determines the proportion of gangliosides, belonging to the a- and b-series.	Gangliosides	188-200	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	91-103
8261439-3	1994	A case in point is GD3, a prominent ganglioside of human malignant melanoma.	Gangliosides	36-47	GRDX	Homo sapiens	19-22
7982239-9	1994	The concentration of NCAM was related to clinical parameters of the patients such as age, sex, blood group status, stage of disease, organ site involvement of metastases, survival, and expression of the ganglioside fucosyl-GM1 (FucGM1).	Gangliosides	203-214	neural cell adhesion molecule 1	Homo sapiens	21-25
8261439-4	1994	Using an approach that has been effective in the construction of bacterial carbohydrate vaccines, we have succeeded in increasing the immunogenicity of GD3 in the mouse by conjugating the ganglioside with immunogenic carriers.	Gangliosides	188-199	GRDX	Homo sapiens	152-155
8180424-3	1994	The ganglioside pattern in the meningosarcoma was different from the previously reported pattern in meningiomas of different histological origin, showing a higher concentration of GD3, indicating that the so-called b pathway of ganglioside biosynthesis was the preferred one in this type of tumor; moreover the percentage content of polysialylated gangliosides was very low.	Gangliosides	4-15	GRDX	Homo sapiens	180-183
8003252-6	1994	Using both the natural substrate ganglioside GM3 and the synthetic compound 4-methylumbelliferyl neuraminate, we found the lysosomal sialidase activity in the prosaposin-deficient cells to be in the normal control range; normal values were also found for the plasma membrane sialidase.	Gangliosides	33-44	prosaposin	Homo sapiens	159-169
8180424-3	1994	The ganglioside pattern in the meningosarcoma was different from the previously reported pattern in meningiomas of different histological origin, showing a higher concentration of GD3, indicating that the so-called b pathway of ganglioside biosynthesis was the preferred one in this type of tumor; moreover the percentage content of polysialylated gangliosides was very low.	Gangliosides	228-239	GRDX	Homo sapiens	180-183
8268317-0	1993	[Amides of ganglioside GD3].	Gangliosides	11-22	GRDX	Homo sapiens	23-26
8294555-1	1994	Pure gangliosides obtained from bovine brain including GM1, GD1b, GT1b and asialo-GM1 (GA1) did not induce normal human B cell proliferation in vitro.	Gangliosides	5-17	coenzyme Q10A	Mus musculus	55-58
8294555-1	1994	Pure gangliosides obtained from bovine brain including GM1, GD1b, GT1b and asialo-GM1 (GA1) did not induce normal human B cell proliferation in vitro.	Gangliosides	5-17	coenzyme Q10A	Mus musculus	82-85
8029444-0	1994	Cell adhesion molecule (NCAM and N-cadherin)-dependent neurite outgrowth is modulated by gangliosides.	Gangliosides	89-101	neural cell adhesion molecule 1	Homo sapiens	24-28
8029444-0	1994	Cell adhesion molecule (NCAM and N-cadherin)-dependent neurite outgrowth is modulated by gangliosides.	Gangliosides	89-101	cadherin 2	Homo sapiens	33-43
8263528-1	1994	Phosphorylation of the nervous system-specific protein GAP-43 in growth cones in vivo increases as the growth cones near their targets, at a time when the gangliosides GM1 and GD1a are being accumulated in the growth cone membrane, thus raising the possibility that the gangliosides could modulate GAP-43 behavior.	Gangliosides	155-167	growth associated protein 43	Homo sapiens	55-61
8263528-1	1994	Phosphorylation of the nervous system-specific protein GAP-43 in growth cones in vivo increases as the growth cones near their targets, at a time when the gangliosides GM1 and GD1a are being accumulated in the growth cone membrane, thus raising the possibility that the gangliosides could modulate GAP-43 behavior.	Gangliosides	270-282	growth associated protein 43	Homo sapiens	55-61
8263528-3	1994	Both gangliosides induced rapid incorporation of phosphate into GAP-43; however, the induction was undetectable with our antibody 2G12 that is specific for kinase C-phosphorylated GAP-43.	Gangliosides	5-17	growth associated protein 43	Homo sapiens	64-70
8263528-5	1994	However, both gangliosides did induce a slower accumulation of GAP-43 phosphorylated on Ser41, apparently by inhibiting a phosphatase.	Gangliosides	14-26	growth associated protein 43	Homo sapiens	63-69
8263528-8	1994	The results demonstrate that both gangliosides can modulate the calcium-dependent regulation of GAP-43.	Gangliosides	34-46	growth associated protein 43	Homo sapiens	96-102
8139390-8	1994	Thus, ganglioside enrichment of LDL is likely to interfere with LDL clearance via the hepatic LDL receptor, and to stimulate binding of LDL to the scavenger receptor of macrophages.	Gangliosides	6-17	low density lipoprotein receptor	Homo sapiens	94-106
8230555-3	1993	A comparison of tumor with normal tissue revealed a significant difference in individual ganglioside expression in which the former consistently expressed eight major gangliosides, GM3, GM2, GM1, GD3, GD1A, GD2, GD1B and GT1B, according to the nomenclature of Svennerholm.	Gangliosides	89-100	GRDX	Homo sapiens	196-199
8218347-2	1993	As a first step in identifying active molecular species, structural characterization and quantification of the purified individual cellular and shed gangliosides of YAC-1 murine lymphoma cells were undertaken.	Gangliosides	149-161	ADP-ribosyltransferase 1	Mus musculus	165-170
8264958-4	1993	More importantly, subthreshold amounts of BDNF were rendered efficacious in the presence of ganglioside GM1: loss of tyrosine hydroxylase positive cells was reduced from 80% to only 20%.	Gangliosides	92-103	brain-derived neurotrophic factor	Rattus norvegicus	42-46
8376939-2	1993	Before treatment with gangliosides, astrocytes expressed constitutive MHC class I but not class II molecules, however, the expression of both MHC class I and II cell surface molecules on astrocytes was induced to high levels by interferon gamma (IFN-gamma).	Gangliosides	22-34	interferon gamma	Bos taurus	228-255
8376939-3	1993	Constitutive and IFN-gamma-inducible expression of MHC class I and II molecules was suppressed by treatment of astrocytes with exogenous bovine brain gangliosides in a dose-dependent manner.	Gangliosides	150-162	interferon gamma	Bos taurus	17-26
8135288-5	1993	Electron microscopic examination and biochemical studies were typical for MLIV, namely, abnormal ganglioside retention and typical pattern of phospholipids accumulation.	Gangliosides	97-108	mucolipin TRP cation channel 1	Homo sapiens	74-78
8400293-7	1993	Furthermore, molecules that have been implicated as candidate plasminogen receptors, gangliosides, and an alpha-enolase--related molecule, also interacted with t-PA.	Gangliosides	85-97	chromosome 20 open reading frame 181	Homo sapiens	160-164
8376989-8	1993	Pretreatment with the ganglioside AGF2 prevented the redistribution of PKC (gamma) in the particulate fraction at 5 min, but not at 10 min of ischemia.	Gangliosides	22-33	protein kinase C, gamma	Rattus norvegicus	71-82
8376989-10	1993	Ganglioside pretreatment delayed the translocation of PKC (gamma), possibly by counter-acting the effects of ischemia-induced factors that favor PKC binding to cell membranes.	Gangliosides	0-11	protein kinase C, gamma	Rattus norvegicus	54-65
8376989-10	1993	Ganglioside pretreatment delayed the translocation of PKC (gamma), possibly by counter-acting the effects of ischemia-induced factors that favor PKC binding to cell membranes.	Gangliosides	0-11	protein kinase C, alpha	Rattus norvegicus	54-57
8232861-1	1993	The influence of various gangliosides on the dynamics of the development of prolonged posttetanic potentiation (PPTP) in the layer of pyramidal cells of field CA3 during the stimulation of mossy fibers was investigated in rat hippocampus section.	Gangliosides	25-37	carbonic anhydrase 3	Rattus norvegicus	159-162
8239497-4	1993	We purified two gangliosides named K-1 and K-2 from gastric cancer cell line KATOIII, and three gangliosides named H-1, H-2, and H-3 from human stomach.	Gangliosides	96-108	H1.5 linker histone, cluster member	Homo sapiens	115-132
8360694-5	1993	The content of C20:1 LCB, generally low at 1 month, increased with age in all analyzed gangliosides and in all subcellular fractions and was greater in the "b series" than in the "a series" gangliosides.	Gangliosides	87-99	clathrin, light chain B	Rattus norvegicus	21-24
8360694-5	1993	The content of C20:1 LCB, generally low at 1 month, increased with age in all analyzed gangliosides and in all subcellular fractions and was greater in the "b series" than in the "a series" gangliosides.	Gangliosides	190-202	clathrin, light chain B	Rattus norvegicus	21-24
8360694-6	1993	Remarkably, GM1 was the only ganglioside where the proportion of LCB 20:1 was higher in the synaptosomal fraction than in the myelin fraction.	Gangliosides	29-40	clathrin, light chain B	Rattus norvegicus	65-68
8360694-7	1993	The fatty acid composition of the C18:1 or C20:1 LCB species of the different gangliosides in the synaptosomal and myelin fractions did not undergo appreciable changes with age.	Gangliosides	78-90	clathrin, light chain B	Rattus norvegicus	49-52
8395211-4	1993	In addition, immunoaffinity-purified EGF receptor preparations contain ganglioside GM3 (Hanai et al.	Gangliosides	71-82	epidermal growth factor receptor	Homo sapiens	37-49
7689178-6	1993	Three-dimensional reconstructions show the neurotoxin bound to the exterior of ganglioside/PC lipid vesicles and show channels entirely perforating the vesicle wall.	Gangliosides	79-90	neurotoxin	Clostridium botulinum	43-53
8233089-0	1993	Ganglioside GD3 enhances adherence of botulinum and tetanus neurotoxins to bovine brain synapsin I.	Gangliosides	0-11	synapsin-1	Bos taurus	88-98
8515285-7	1993	These results demonstrate that all gangliosides tested, except GM3, probably inhibit PDGF-mediated growth by preventing dimerization of PDGFR monomers.	Gangliosides	35-47	platelet derived growth factor receptor beta	Homo sapiens	136-141
8370046-0	1993	A synthetic approach to polysialogangliosides containing alpha-sialyl-(2-->8)-sialic acid: total synthesis of ganglioside GD3.	Gangliosides	33-44	GRDX	Homo sapiens	125-128
8370046-1	1993	A stereocontrolled, facile total synthesis of ganglioside GD3 is described as an example of a proposed systematic approach to the preparation of gangliosides containing an alpha-sialyl-(2-->8)-sialic acid unit alpha-glycosidically linked to O-3 of a D-galactose residue in their oligosaccharide chains.	Gangliosides	46-57	GRDX	Homo sapiens	58-61
8370046-1	1993	A stereocontrolled, facile total synthesis of ganglioside GD3 is described as an example of a proposed systematic approach to the preparation of gangliosides containing an alpha-sialyl-(2-->8)-sialic acid unit alpha-glycosidically linked to O-3 of a D-galactose residue in their oligosaccharide chains.	Gangliosides	145-157	GRDX	Homo sapiens	58-61
8370046-6	1993	This glycoside was easily transformed, via selective reduction of the azido group, condensation with octadecanoic acid, O-deacylation, and hydrolysis of the methyl ester and lactone functions, into ganglioside GD3.	Gangliosides	198-209	GRDX	Homo sapiens	210-213
7691279-0	1993	The 3G11+ antigen, a marker for murine CD4+ TH1 lymphocytes, is a ganglioside.	Gangliosides	66-77	CD4 antigen	Mus musculus	39-42
7691279-0	1993	The 3G11+ antigen, a marker for murine CD4+ TH1 lymphocytes, is a ganglioside.	Gangliosides	66-77	negative elongation factor complex member C/D, Th1l	Mus musculus	44-47
8407875-0	1993	Generation of a monoclonal antibody specific for ganglioside GM4: evidence for GM4 expression on astrocytes in chicken cerebellum.	Gangliosides	49-60	T cell receptor alpha variable 6-3	Mus musculus	61-64
8407875-0	1993	Generation of a monoclonal antibody specific for ganglioside GM4: evidence for GM4 expression on astrocytes in chicken cerebellum.	Gangliosides	49-60	T cell receptor alpha variable 6-3	Mus musculus	79-82
8407875-1	1993	We established a murine monoclonal antibody (MAb) specific for ganglioside GM4 by immunizing C3H/HeN mice with chemically synthesized GM4 adsorbed to Salmonella minnesota, followed by fusion with mouse myeloma cells.	Gangliosides	63-74	T cell receptor alpha variable 6-3	Mus musculus	75-78
8407875-1	1993	We established a murine monoclonal antibody (MAb) specific for ganglioside GM4 by immunizing C3H/HeN mice with chemically synthesized GM4 adsorbed to Salmonella minnesota, followed by fusion with mouse myeloma cells.	Gangliosides	63-74	T cell receptor alpha variable 6-3	Mus musculus	134-137
8407875-2	1993	The MAb, designated as AMR10, was shown to exhibit high binding specificity, reacting only with the ganglioside GM4 used for immunization and native GM4 from human brain.	Gangliosides	100-111	T cell receptor alpha variable 6-3	Mus musculus	112-115
8515285-2	1993	This correlated with the inhibitory effects of several gangliosides (except GM3) on tyrosine phosphorylation of the PDGF receptor (PDGFR).	Gangliosides	55-67	platelet derived growth factor receptor, beta polypeptide	Mus musculus	116-129
8515285-2	1993	This correlated with the inhibitory effects of several gangliosides (except GM3) on tyrosine phosphorylation of the PDGF receptor (PDGFR).	Gangliosides	55-67	platelet derived growth factor receptor, beta polypeptide	Mus musculus	131-136
8379955-2	1993	The structure of GM3 has been established on the basis of chemical methods, enzymatic degradation, GC-MS, as well as plasma desorption mass spectrometry and HPLC of 9-anthrylmethyl esters of gangliosides to characterize the long-chain base composition.	Gangliosides	191-203	granulocyte macrophage antigen 3	Mus musculus	17-20
7691667-8	1993	Conformational protein epitopes in glutamate decarboxylase therefore show a sensitivity to biochemical treatment of sections such as ganglioside epitopes.	Gangliosides	133-144	glutamate-ammonia ligase	Homo sapiens	35-58
8410057-2	1993	In addition, a subset of patients with neuroborreliosis (29%) and syphilis (59%) had IgM reactivity to gangliosides with a Gal(beta 1-3) GalNac terminal sequence (GM1, GD1b, and asialo GM1).	Gangliosides	103-115	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	127-135
8410057-6	1993	Given the clinical associations of patients with neuroborreliosis and syphilis with IgM reactivity to gangliosides sharing the Gal(beta 1-3) GalNac terminus, we suggest that these antibodies could represent a response to injury in neurological disease or a cross reactive event caused by spirochetes.	Gangliosides	102-114	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	131-139
8515285-8	1993	Loss of more complex gangliosides in human gliomas would permit unregulated activation of the PDGFR, contributing to uncontrolled growth stimulation.	Gangliosides	21-33	platelet derived growth factor receptor beta	Homo sapiens	94-99
8103682-1	1993	By means of light and confocal laser microscopical analysis of choleratoxin (CT) binding sites indicating the localization of the ganglioside GM1, evidence has been obtained for the presence of ganglioside GM1 in discrete nerve terminals, some of them identified by synapsin-1 immunoreactivity (IR), with a focal distribution in the nerve terminal membrane.	Gangliosides	194-205	synapsin I	Rattus norvegicus	266-276
8320001-7	1993	NG2-labeled cells of embryonic animals expressed GD3 ganglioside antigens, a property of oligodendrocyte precursors, whereas NG2-positive cells of postnatal animals did not express GD3 immunoreactivity.	Gangliosides	53-64	chondroitin sulfate proteoglycan 4	Rattus norvegicus	0-3
8102177-2	1993	To determine if the distribution of exogenous ganglioside (GM1) in neuronal membranes is related to neuritogenesis, the surface topography of exogenous ganglioside in these cells was examined by localization with cholera toxin B-FITC.	Gangliosides	46-57	coenzyme Q10A	Mus musculus	59-62
8509130-7	1993	Ganglioside-treated cells recovered their high-affinity [125I]IL-2 binding after washing.	Gangliosides	0-11	interleukin 2	Homo sapiens	62-66
8509130-9	1993	A thin-layer chromatography overlay technique was used to demonstrate that IL-2 binds directly to gangliosides, but not to simple neutral glycolipids or acidic lipids.	Gangliosides	98-110	interleukin 2	Homo sapiens	75-79
8509130-10	1993	Taken together, these findings indicate that gangliosides directly block the interaction of IL-2 with IL-2R, and may explain, in part, the immunosuppressive activities of gangliosides in vivo.	Gangliosides	45-57	interleukin 2	Homo sapiens	92-96
8509130-10	1993	Taken together, these findings indicate that gangliosides directly block the interaction of IL-2 with IL-2R, and may explain, in part, the immunosuppressive activities of gangliosides in vivo.	Gangliosides	45-57	interleukin 2 receptor subunit alpha	Homo sapiens	102-107
8509130-10	1993	Taken together, these findings indicate that gangliosides directly block the interaction of IL-2 with IL-2R, and may explain, in part, the immunosuppressive activities of gangliosides in vivo.	Gangliosides	171-183	interleukin 2	Homo sapiens	92-96
8509130-10	1993	Taken together, these findings indicate that gangliosides directly block the interaction of IL-2 with IL-2R, and may explain, in part, the immunosuppressive activities of gangliosides in vivo.	Gangliosides	171-183	interleukin 2 receptor subunit alpha	Homo sapiens	102-107
8518932-4	1993	In agreement with the increased ganglioside concentration the activities of sialidase, beta-galactosidase, beta-glucosidase and beta-hexosaminidase, which are likely to be involved in the catabolism of gangliosides, showed reductions due to alcohol.	Gangliosides	32-43	galactosidase, beta 1	Rattus norvegicus	87-105
8518932-4	1993	In agreement with the increased ganglioside concentration the activities of sialidase, beta-galactosidase, beta-glucosidase and beta-hexosaminidase, which are likely to be involved in the catabolism of gangliosides, showed reductions due to alcohol.	Gangliosides	32-43	O-GlcNAcase	Rattus norvegicus	128-147
8518932-4	1993	In agreement with the increased ganglioside concentration the activities of sialidase, beta-galactosidase, beta-glucosidase and beta-hexosaminidase, which are likely to be involved in the catabolism of gangliosides, showed reductions due to alcohol.	Gangliosides	202-214	galactosidase, beta 1	Rattus norvegicus	87-105
8518932-4	1993	In agreement with the increased ganglioside concentration the activities of sialidase, beta-galactosidase, beta-glucosidase and beta-hexosaminidase, which are likely to be involved in the catabolism of gangliosides, showed reductions due to alcohol.	Gangliosides	202-214	O-GlcNAcase	Rattus norvegicus	128-147
7682808-7	1993	Furthermore, ganglioside depletion of CMH5123 cells decreased the affinity of vitronectin receptors for vitronectin without modifying their number, affinity of vitronectin receptors was re-established in ganglioside-depleted cells by supplementing their growth media with complex gangliosides.	Gangliosides	13-24	vitronectin	Rattus norvegicus	78-89
7682808-7	1993	Furthermore, ganglioside depletion of CMH5123 cells decreased the affinity of vitronectin receptors for vitronectin without modifying their number, affinity of vitronectin receptors was re-established in ganglioside-depleted cells by supplementing their growth media with complex gangliosides.	Gangliosides	13-24	vitronectin	Rattus norvegicus	104-115
7682808-7	1993	Furthermore, ganglioside depletion of CMH5123 cells decreased the affinity of vitronectin receptors for vitronectin without modifying their number, affinity of vitronectin receptors was re-established in ganglioside-depleted cells by supplementing their growth media with complex gangliosides.	Gangliosides	13-24	vitronectin	Rattus norvegicus	104-115
8462156-10	1993	Immunoperoxidase stains demonstrated asialo GM1 ganglioside antibody-positive, granular lymphocytes to be much more frequent in myocardium of IL-2-treated rats than in that of control rats.	Gangliosides	48-59	interleukin 2	Rattus norvegicus	142-146
8354518-0	1993	Sugar-specific interaction of bovine brain beta-galactoside-binding lectin with endogenous gangliosides.	Gangliosides	91-103	galactoside-binding soluble lectin 13	Bos taurus	43-74
8354518-1	1993	Sugar-specific binding of the 14 kDa beta-galactoside-binding lectin from bovine brain grey matter to mixed endogenous gangliosides was demonstrated by affinity electrophoresis and hemagglutination inhibition.	Gangliosides	119-131	galactoside-binding soluble lectin 13	Bos taurus	37-68
8500110-1	1993	Ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin has been focused on as a target molecule for passive immunotherapy.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
8500110-1	1993	Ganglioside GD3, which is one of the major gangliosides expressed on the cell surface of human tumors of neuroectodermal origin has been focused on as a target molecule for passive immunotherapy.	Gangliosides	43-55	GRDX	Homo sapiens	12-15
8395464-4	1993	We show here that SM1 antibody reacts with a group of fucose-containing neutral glycolipids and gangliosides many of which are cross-reactive with antibodies to H antigens.	Gangliosides	96-108	SM1	Homo sapiens	18-21
8397712-4	1993	Homozygous nude mice (nu/nu), which lack T-cells, and heterozygous controls (nu/+) with intact T-cells, were immunized and rechallenged with the ganglioside GM1 in liposomes.	Gangliosides	145-156	coenzyme Q10A	Mus musculus	157-160
8397712-6	1993	Both nude mice and controls produced high titers of IgM class antibodies to the ganglioside GM1.	Gangliosides	80-91	coenzyme Q10A	Mus musculus	92-95
8486686-12	1993	Incubations with CMP-Neu5Ac and acetyl-CoA corroborated the results with brefeldin A, co-localizing ganglioside O-acetyltransferase activity in compartments where GD3 biosynthesis takes place.	Gangliosides	100-111	CAS1 domain containing 1	Homo sapiens	112-131
8486686-12	1993	Incubations with CMP-Neu5Ac and acetyl-CoA corroborated the results with brefeldin A, co-localizing ganglioside O-acetyltransferase activity in compartments where GD3 biosynthesis takes place.	Gangliosides	100-111	GRDX	Homo sapiens	163-166
8486686-14	1993	Labeling with acetyl-CoA and UDP-GalNAc indicated that although labeled acetate can be transferred from acetyl-CoA directly to GD2, ganglioside O-acetyltransferase activity does not substantially overlap with the biosynthetic compartment(s) for GD2.	Gangliosides	132-143	CAS1 domain containing 1	Homo sapiens	144-163
8318834-5	1993	Neuraminidase treatment of gangliosides with alpha 2-3 substituted sialic acid is necessary prior to immunostaining whereas alpha 2-6 sialylated gangliosides can be detected without enzyme treatment.	Gangliosides	27-39	neuraminidase 1	Homo sapiens	0-13
8318834-5	1993	Neuraminidase treatment of gangliosides with alpha 2-3 substituted sialic acid is necessary prior to immunostaining whereas alpha 2-6 sialylated gangliosides can be detected without enzyme treatment.	Gangliosides	145-157	immunoglobulin binding protein 1	Homo sapiens	124-133
8509130-0	1993	Gangliosides inhibit T-lymphocyte proliferation by preventing the interaction of interleukin-2 with its cell surface receptors.	Gangliosides	0-12	interleukin 2	Homo sapiens	81-94
8509130-1	1993	Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2).	Gangliosides	0-12	interleukin 2	Homo sapiens	219-232
8509130-1	1993	Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2).	Gangliosides	0-12	interleukin 2	Homo sapiens	234-238
8509130-1	1993	Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2).	Gangliosides	107-119	interleukin 2	Homo sapiens	219-232
8509130-1	1993	Gangliosides are known to be actively shed from tumour cell membranes, and increased levels of circulating gangliosides may cause tumour-induced T-lymphocyte immunosuppression in vivo by interfering with the actions of interleukin-2 (IL-2).	Gangliosides	107-119	interleukin 2	Homo sapiens	234-238
8509130-2	1993	We have investigated the effect of gangliosides on the interaction of IL-2 with its cell surface receptors (IL-2R).	Gangliosides	35-47	interleukin 2	Homo sapiens	70-74
8509130-2	1993	We have investigated the effect of gangliosides on the interaction of IL-2 with its cell surface receptors (IL-2R).	Gangliosides	35-47	interleukin 2 receptor subunit alpha	Homo sapiens	108-113
8509130-3	1993	Gangliosides inhibited IL-2-stimulated proliferation in synchronized populations of the IL-2-dependent cell lines CTLL-2 and HT-2.	Gangliosides	0-12	interleukin 2	Homo sapiens	23-27
8509130-3	1993	Gangliosides inhibited IL-2-stimulated proliferation in synchronized populations of the IL-2-dependent cell lines CTLL-2 and HT-2.	Gangliosides	0-12	interleukin 2	Homo sapiens	88-92
8509130-4	1993	The immunosuppressive effect was most effective when gangliosides were added during the first 4 hr after IL-2-stimulation, indicating that they acted early in the IL-2 signalling pathway.	Gangliosides	53-65	interleukin 2	Homo sapiens	105-109
8509130-4	1993	The immunosuppressive effect was most effective when gangliosides were added during the first 4 hr after IL-2-stimulation, indicating that they acted early in the IL-2 signalling pathway.	Gangliosides	53-65	interleukin 2	Homo sapiens	163-167
8509130-5	1993	Inhibition could be completely overcome by exogenous IL-2, suggesting that gangliosides inhibited growth solely by competing with IL-2R for available IL-2.	Gangliosides	75-87	interleukin 2	Homo sapiens	53-57
8509130-5	1993	Inhibition could be completely overcome by exogenous IL-2, suggesting that gangliosides inhibited growth solely by competing with IL-2R for available IL-2.	Gangliosides	75-87	interleukin 2 receptor subunit alpha	Homo sapiens	130-135
8509130-5	1993	Inhibition could be completely overcome by exogenous IL-2, suggesting that gangliosides inhibited growth solely by competing with IL-2R for available IL-2.	Gangliosides	75-87	interleukin 2	Homo sapiens	130-134
8509130-6	1993	In support of this proposal, gangliosides induced a concomitant dose-dependent decrease in binding of [125I]IL-2 to high-, medium- and low-affinity IL-2R.	Gangliosides	29-41	interleukin 2	Homo sapiens	108-112
8509130-6	1993	In support of this proposal, gangliosides induced a concomitant dose-dependent decrease in binding of [125I]IL-2 to high-, medium- and low-affinity IL-2R.	Gangliosides	29-41	interleukin 2 receptor subunit alpha	Homo sapiens	148-153
8319494-2	1993	The results showed that all three of the human uveal melanoma cell lines tested expressed GD2 and GD3 gangliosides in vitro and in vivo.	Gangliosides	102-114	GRDX	Homo sapiens	98-101
8319494-6	1993	The expression of GD2 and GD3 surface gangliosides on uveal melanomas and the capacity of anti-ganglioside antibodies to inhibit metastasis formation in mouse models of ocular and cutaneous melanomas raise the possibility of implementing anti-ganglioside antibodies as potential therapeutic agents for the management of uveal melanoma.	Gangliosides	38-50	GRDX	Homo sapiens	26-29
8319494-6	1993	The expression of GD2 and GD3 surface gangliosides on uveal melanomas and the capacity of anti-ganglioside antibodies to inhibit metastasis formation in mouse models of ocular and cutaneous melanomas raise the possibility of implementing anti-ganglioside antibodies as potential therapeutic agents for the management of uveal melanoma.	Gangliosides	38-49	GRDX	Homo sapiens	26-29
8473052-3	1993	The ganglioside pattern was shown to have GM3, GM2, GM1, GD3, GD2, GD1b and GT1b as the major components.	Gangliosides	4-15	GRDX	Homo sapiens	57-60
8455041-1	1993	Exogenous gangliosides, especially ganglioside GM1 (GM1), seem to potentiate the action of nerve growth factor (NGF).	Gangliosides	10-22	nerve growth factor	Rattus norvegicus	91-110
8455041-1	1993	Exogenous gangliosides, especially ganglioside GM1 (GM1), seem to potentiate the action of nerve growth factor (NGF).	Gangliosides	10-22	nerve growth factor	Rattus norvegicus	112-115
8466487-1	1993	Sialated glycosphingolipids (gangliosides) were recently shown to induce internalisation of the CD4 Ag in lymphoid cells and dissociation of p56lck from CD4 (Repke et al.	Gangliosides	29-41	CD4 molecule	Homo sapiens	96-99
8466487-1	1993	Sialated glycosphingolipids (gangliosides) were recently shown to induce internalisation of the CD4 Ag in lymphoid cells and dissociation of p56lck from CD4 (Repke et al.	Gangliosides	29-41	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	141-147
8466487-1	1993	Sialated glycosphingolipids (gangliosides) were recently shown to induce internalisation of the CD4 Ag in lymphoid cells and dissociation of p56lck from CD4 (Repke et al.	Gangliosides	29-41	CD4 molecule	Homo sapiens	153-156
8358227-4	1993	Glycoproteins like fetuin and saponified bovine submandibular gland mucin, most of them having alpha(2-6) linked sialic acids, are preferred substrates, while sialic acids from gangliosides, sialyllactoses, or the alpha(2-8) linked sialic acid polymer (colominic acid) are hydrolysed at lower rates.	Gangliosides	177-189	mucin 1, cell surface associated	Bos taurus	68-73
8514331-0	1993	Gangliosides protect from TNF alpha-induced apoptosis.	Gangliosides	0-12	tumor necrosis factor	Bos taurus	26-35
8514331-1	1993	The modulation of tumor necrosis factor alpha-mediated cytotoxicity by gangliosides was analyzed.	Gangliosides	71-83	tumor necrosis factor	Bos taurus	18-45
8514331-3	1993	The presence of a bovine brain ganglioside mixture (BBG, Cronassial) inhibited the TNF alpha-mediated lysis in a dose-dependent manner (IC50 approximately 1 mg/ml).	Gangliosides	31-42	tumor necrosis factor	Bos taurus	83-92
7683980-1	1993	The distribution of the cholinergic-specific ganglioside antigen Chol-1 has been studied by indirect fluorescence immunohistochemistry in mouse spinal cord neurons developing in vitro.	Gangliosides	45-56	cholesterol 1	Mus musculus	65-71
8439988-1	1993	Ganglioside GD3, which is one of the major gangliosides expressed on the cell surface human tumors of neuroectodermal origin, has been studied as a target molecule for passive immunotherapy.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
7678417-4	1993	FUA169 cells were characterized by a dramatic reduction in LacCer and by the presence of a major ganglioside identified as GM3.	Gangliosides	97-108	granulocyte macrophage antigen 3	Mus musculus	123-126
8418889-0	1993	Characterization of the neutral pH-optimum sphingomyelinase from rat brain: inhibition by copper II and ganglioside GM3.	Gangliosides	104-115	sphingomyelin phosphodiesterase 2	Rattus norvegicus	24-59
8418889-10	1993	Gangliosides, particularly the monosialoganglioside, GM3 (IC50 approximately 50 microM), inhibited N-SMase.	Gangliosides	0-12	sphingomyelin phosphodiesterase 2	Rattus norvegicus	99-106
8469369-2	1993	Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5.	Gangliosides	175-186	fibroblast growth factor 2	Homo sapiens	0-30
8469369-2	1993	Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5.	Gangliosides	175-186	fibroblast growth factor 2	Homo sapiens	32-36
8469369-2	1993	Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5.	Gangliosides	175-186	epidermal growth factor	Homo sapiens	39-62
8469369-2	1993	Basic fibroblast growth factor (bFGF), epidermal growth factor (EGF) but not platelet-derived growth factor (PDGF) induced an increase in the number of cells positive for the ganglioside-recognizing monoclonal antibody, A2B5.	Gangliosides	175-186	epidermal growth factor	Homo sapiens	64-67
7905728-10	1993	Taken together, in human keratinocytes, gangliosides differentially affect some other as yet unidentified site(s) in the post-calcium transmission pathway(s) which leads to TGase activation.	Gangliosides	40-52	coagulation factor XIII B chain	Homo sapiens	173-178
8106089-0	1993	Ganglioside (GM1) distinguishes the effects of CD4 on signal transduction through the TCR/CD3 complex in human lymphocytes.	Gangliosides	0-11	CD4 molecule	Homo sapiens	47-50
8106089-1	1993	Ganglioside (GM1) modulation of CD4 off the surface of T lymphocytes defined functions of the CD4 molecule during signal transduction through the T cell receptor (TCR)/CD3 complex.	Gangliosides	0-11	CD4 molecule	Homo sapiens	32-35
8106089-1	1993	Ganglioside (GM1) modulation of CD4 off the surface of T lymphocytes defined functions of the CD4 molecule during signal transduction through the T cell receptor (TCR)/CD3 complex.	Gangliosides	0-11	CD4 molecule	Homo sapiens	94-97
8439988-0	1993	Antitumor effects of a novel monoclonal antibody with high binding affinity to ganglioside GD3.	Gangliosides	79-90	GRDX	Homo sapiens	91-94
8439988-1	1993	Ganglioside GD3, which is one of the major gangliosides expressed on the cell surface human tumors of neuroectodermal origin, has been studied as a target molecule for passive immunotherapy.	Gangliosides	43-55	GRDX	Homo sapiens	12-15
8439988-4	1993	Immunostaining of gangliosides, separated on thin-layer chromatography plates, using KM641 revealed that most of the melanoma cell lines contained immunoreactive GD3 and GD3-lactone at a high level, but only the adrenal gland and the urinary bladder out of 21 human normal tissues had immunoreactive GD3.	Gangliosides	18-30	GRDX	Homo sapiens	162-165
8422703-0	1993	Expression of ganglioside GM3 and H-2 antigens in clones with different metastatic and growth potentials isolated from Lewis lung carcinoma (3LL) cell line.	Gangliosides	14-25	granulocyte macrophage antigen 3	Mus musculus	26-29
8422703-4	1993	The degree of cell surface expression of GM3 among the clones correlated well with their total cellular content of this ganglioside.	Gangliosides	120-131	granulocyte macrophage antigen 3	Mus musculus	41-44
8416794-3	1993	All gangliosides tested inhibited the PDGF-stimulated increases in free intracellular calcium concentrations ([Ca2+]i) with the rank order of potency being GM1 > or = GT1b > GM2 > GM3.	Gangliosides	4-16	granulocyte macrophage antigen 3	Mus musculus	189-192
8416794-5	1993	Preincubating the cells with specific gangliosides inhibited tyrosine phosphorylation of this protein in a dose-responsive fashion with the following rank order of potency GD1a = GT1b > GM1 > GM2 > GM3.	Gangliosides	38-50	granulocyte macrophage antigen 3	Mus musculus	207-210
8417168-0	1993	Expression of gangliosides GD3 and 3"-isoLM1 in autopsy brains from patients with malignant tumors.	Gangliosides	14-26	GRDX	Homo sapiens	27-30
8417168-2	1993	The study focused on the gangliosides GD3 and 3"-isoLM1, which in a previous study of biopsies were found to be associated with these tumors.	Gangliosides	25-37	GRDX	Homo sapiens	38-41
8417168-4	1993	The highest concentrations (200-1,000 nmol of sialic acid/g wet weight) of GD3 was found in specimens of macroscopically pure tumor, where the proportion of GD3 was, at the most, 78% (range, 11-78%) of the total ganglioside sialic acid compared with < 10% in normal brain tissue.	Gangliosides	212-223	GRDX	Homo sapiens	75-78
8417168-5	1993	The proportion of the total ganglioside sialic acid made up by GD3 was also elevated in the periphery of the tumor and in the same region in the opposite hemisphere, where no tumor cells were detected.	Gangliosides	28-39	GRDX	Homo sapiens	63-66
8417168-6	1993	In four of eight brain metastases of various carcinomas, GD3 was > 10% of the total ganglioside sialic acid (range, 3-37%).	Gangliosides	87-98	GRDX	Homo sapiens	57-60
8417139-3	1993	Two main LCBs were components of the ganglioside species of cultured cells, the C18:1 LCB and the C20:1 LCB.	Gangliosides	37-48	clathrin, light chain B	Rattus norvegicus	9-12
1333416-2	1992	In contrast to calmodulin-binding gangliosides, these glycosphingolipids activated the enzyme up to the maximum level achieved by Ca2+/calmodulin and did not inhibit the activity at higher concentrations.	Gangliosides	34-46	calmodulin 1	Homo sapiens	15-25
1454804-0	1992	Binding and transport of gangliosides by prosaposin.	Gangliosides	25-37	prosaposin	Homo sapiens	41-51
1333954-0	1992	Ganglioside binding proteins of calf brain with ubiquitin-like N-terminals.	Gangliosides	0-11	ubiquitin	Bos taurus	48-57
1292783-1	1992	R24 is a mouse IgG3 monoclonal antibody that reacts with the ganglioside GD3 expressed by melanoma cells and other cells of neuroectodermal origin (e.g. adrenal medulla).	Gangliosides	61-72	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	15-19
1292783-1	1992	R24 is a mouse IgG3 monoclonal antibody that reacts with the ganglioside GD3 expressed by melanoma cells and other cells of neuroectodermal origin (e.g. adrenal medulla).	Gangliosides	61-72	GRDX	Homo sapiens	73-76
1457415-0	1992	Gangliosides: differentiation markers for murine T helper lymphocyte subpopulations TH1 and TH2.	Gangliosides	0-12	negative elongation factor complex member C/D, Th1l	Mus musculus	84-87
1457415-0	1992	Gangliosides: differentiation markers for murine T helper lymphocyte subpopulations TH1 and TH2.	Gangliosides	0-12	heart and neural crest derivatives expressed 2	Mus musculus	92-95
1457415-5	1992	A comparison of the gangliosides by thin-layer chromatography showed differences between the TH1 and TH2 cells.	Gangliosides	20-32	negative elongation factor complex member C/D, Th1l	Mus musculus	93-96
1457415-5	1992	A comparison of the gangliosides by thin-layer chromatography showed differences between the TH1 and TH2 cells.	Gangliosides	20-32	heart and neural crest derivatives expressed 2	Mus musculus	101-104
1485537-2	1992	As a model of GSL antigen, ganglioside GD3 was used.	Gangliosides	27-38	GRDX	Homo sapiens	39-42
1485537-3	1992	An IgM monoclonal antibody (DSG-1) specific for ganglioside GD3 was preincubated with standard inhibitor liposomes containing ganglioside GD3.	Gangliosides	48-59	desmoglein 1	Homo sapiens	28-33
1485537-3	1992	An IgM monoclonal antibody (DSG-1) specific for ganglioside GD3 was preincubated with standard inhibitor liposomes containing ganglioside GD3.	Gangliosides	48-59	GRDX	Homo sapiens	60-63
1485537-7	1992	Pg to ng of ganglioside GD3 could be detected.	Gangliosides	12-23	GRDX	Homo sapiens	24-27
1485537-8	1992	Furthermore, ganglioside GD3 on the cells was investigated with SK-MEL-28 human melanoma cell line and human red blood cells (HRBC).	Gangliosides	13-24	GRDX	Homo sapiens	25-28
1485537-9	1992	When SK-MEL-28 melanoma with ganglioside GD3 was used as an inhibitor, specific inhibition was observed.	Gangliosides	29-40	GRDX	Homo sapiens	41-44
1485537-12	1992	The amount of ganglioside GD3/melanoma cell was estimated to be at least 1.1 x 10(-14) g from the standard curve made with the liposomes containing 10% epitope density of ganglioside GD3.	Gangliosides	14-25	GRDX	Homo sapiens	26-29
1485537-12	1992	The amount of ganglioside GD3/melanoma cell was estimated to be at least 1.1 x 10(-14) g from the standard curve made with the liposomes containing 10% epitope density of ganglioside GD3.	Gangliosides	14-25	GRDX	Homo sapiens	183-186
1485537-12	1992	The amount of ganglioside GD3/melanoma cell was estimated to be at least 1.1 x 10(-14) g from the standard curve made with the liposomes containing 10% epitope density of ganglioside GD3.	Gangliosides	171-182	GRDX	Homo sapiens	26-29
1461381-1	1992	We used a high-performance liquid chromatography method to measure CSF gangliosides, neutral glycolipids, and sulfatides in patients with lysosomal storage disorders.	Gangliosides	71-83	colony stimulating factor 2	Homo sapiens	67-70
1454804-2	1992	Prosaposin and saposins A,B, C, and D formed stable complexes with 13 different gangliosides as measured by an assay using column chromatography.	Gangliosides	80-92	prosaposin	Homo sapiens	0-10
1454804-4	1992	Prosaposin and saposins transferred gangliosides from donor liposomes to erythrocyte ghost membranes.	Gangliosides	36-48	prosaposin	Homo sapiens	0-10
1454804-5	1992	Prosaposin also stimulated ganglioside GM1 beta-galactosidase more than mature saposins.	Gangliosides	27-38	prosaposin	Homo sapiens	0-10
1454804-6	1992	Prosaposin exists as a secretory protein and as an integral membrane protein, and we propose that prosaposin is active as a ganglioside binding and transport protein in vivo.	Gangliosides	124-135	prosaposin	Homo sapiens	98-108
1401895-0	1992	Ganglioside-induced CD4 endocytosis occurs independent of serine phosphorylation and is accompanied by dissociation of P56lck.	Gangliosides	0-11	CD4 molecule	Homo sapiens	20-23
1481629-2	1992	Differing ganglioside antibody patterns in CSF but not serum allowed to reclassify 93% of MS patients correctly when compared to patients with Guillain-Barre syndrome or neuroborreliosis.	Gangliosides	10-21	colony stimulating factor 2	Homo sapiens	43-46
1481629-4	1992	CSF ganglioside antibody titres were found to be different for patients with relapsing remitting (RRMS; n = 35) and chronic progressive (CPMS; n = 13) multiple sclerosis.	Gangliosides	4-15	colony stimulating factor 2	Homo sapiens	0-3
1293169-5	1992	(4) Gangliosides inhibited the proliferation of human T cells stimulated with interleukin-4 or interleukin-2.	Gangliosides	4-16	interleukin 4	Homo sapiens	78-91
1293169-5	1992	(4) Gangliosides inhibited the proliferation of human T cells stimulated with interleukin-4 or interleukin-2.	Gangliosides	4-16	interleukin 2	Homo sapiens	95-108
1401895-0	1992	Ganglioside-induced CD4 endocytosis occurs independent of serine phosphorylation and is accompanied by dissociation of P56lck.	Gangliosides	0-11	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	119-125
1401895-1	1992	Gangliosides induce a selective and complete modulation of CD4 from the surface of T cells.	Gangliosides	0-12	CD4 molecule	Homo sapiens	59-62
1401895-4	1992	Ganglioside-induced CD4 endocytosis is accompanied by the loss of p56lck activity associated with CD4.	Gangliosides	0-11	CD4 molecule	Homo sapiens	20-23
1401895-4	1992	Ganglioside-induced CD4 endocytosis is accompanied by the loss of p56lck activity associated with CD4.	Gangliosides	0-11	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	66-72
1401895-4	1992	Ganglioside-induced CD4 endocytosis is accompanied by the loss of p56lck activity associated with CD4.	Gangliosides	0-11	CD4 molecule	Homo sapiens	98-101
1401895-6	1992	The kinetics of p56lck dissociation after ganglioside treatment is identical to that of CD4 endocytosis, suggesting that p56lck is displaced in the process of endosome formation.	Gangliosides	42-53	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	16-22
1401895-6	1992	The kinetics of p56lck dissociation after ganglioside treatment is identical to that of CD4 endocytosis, suggesting that p56lck is displaced in the process of endosome formation.	Gangliosides	42-53	LCK proto-oncogene, Src family tyrosine kinase	Homo sapiens	121-127
1384525-3	1992	Epitopic specificity of isolated ganglioside hybridomas was determined with FAB-MS defined ganglioside standards.	Gangliosides	33-44	FA complementation group B	Homo sapiens	76-79
1337704-4	1992	The intravenous administration of gangliosides (30 mg/kg) resulted in partial normalization of Na+, K+(-)ATPase activity, of LPO product and lysoPC content and of transbilayer distribution of lipids.	Gangliosides	34-46	lactoperoxidase	Rattus norvegicus	125-128
1490105-0	1992	Ganglioside alterations in YAC-1 cells cultivated in serum-supplemented and serum-free growth medium.	Gangliosides	0-11	ADP-ribosyltransferase 1	Mus musculus	27-32
1490105-1	1992	Gangliosides of the "GM1b-pathway" (GM1b and GalNAc-GM1b) have been found to be highly expressed by the mouse T lymphoma YAC-1 grown in serum-supplemented medium, whereas GM2 and GM1 ("GM1a-pathway") occurred only in low amounts [Muthing, J., Peter-Katalinic, J., Hanisch, F.-G., Neumann, U.	Gangliosides	0-12	ADP-ribosyltransferase 1	Mus musculus	121-126
1490105-3	1992	Considerable differences in the ganglioside composition of YAC-1 cells grown in serum-supplemented and in well defined serum-free medium were observed.	Gangliosides	32-43	ADP-ribosyltransferase 1	Mus musculus	59-64
1384262-1	1992	A 77-year-old man presented sensory-dominant neuropathy associated with IgM M-protein reacting with various gangliosides.	Gangliosides	108-120	myomesin 2	Homo sapiens	76-85
1396669-0	1992	Degradation of gangliosides by the lysosomal sialidase requires an activator protein.	Gangliosides	15-27	neuraminidase 1	Homo sapiens	35-54
1463934-1	1992	A new method for the detection of gangliosides based on the lipophilic fluorescence agent 4-(N,N-dihexadecyl)amino-7-nitrobenz-2-oxa-1,3-diazole (NBD dihexadecylamine) and its application for preparative high performance thin layer chromatography is described.	Gangliosides	34-46	OXA1L mitochondrial inner membrane protein	Homo sapiens	129-134
1459340-1	1992	The major ganglioside NeuAc alpha 2-->3Gal beta 1-->4Glc beta 1-->1Cer (GM3) present in cultured rat granulosa cells was examined for potential function in the expression of luteinizing hormone (LH) receptor on the cell surface in response to follicle-stimulating hormone (FSH).	Gangliosides	10-21	luteinizing hormone/choriogonadotropin receptor	Rattus norvegicus	183-216
1421099-1	1992	The semisynthetic ganglioside derivative LIGA20 (II3Neu5-AcGgOse4-2-d-erythro-1,3-dihydroxy-2-dichloro-ac eta mide-4-trans-octadacene) was found to be about ten times more potent than the natural ganglioside GM1 in protecting neurones in culture against glutamate toxicity.	Gangliosides	18-29	endothelin receptor type A	Rattus norvegicus	106-109
1417810-0	1992	CDw 60 antibodies bind to acetylated forms of ganglioside GD3.	Gangliosides	46-57	GRDX	Homo sapiens	58-61
1417810-1	1992	Four monoclonal antibodies, M-T21, M-T32, M-T41 and UM4D4, which belong to the new CDw 60 cluster of antibodies specific for a subpopulation of human T-lymphocytes, were found to bind mainly to acetylated forms of ganglioside GD3.	Gangliosides	214-225	GRDX	Homo sapiens	226-229
1407435-4	1992	In meningiomas and astrocytomas, GM3 and GD3 were the major gangliosides.	Gangliosides	60-72	GRDX	Homo sapiens	41-44
1407435-5	1992	The tumor content of the rather simple gangliosides (GM3, GM2, GD3, GD2) increased or was almost equal to that of normal tissue (leptomeninges tissue in the case of meningiomas, and brain tissue in the case of astrocytomas), while the tumor content of complex gangliosides (GM1, GD1a, GT1a, GT1b) decreased as compared with normal tissue.	Gangliosides	39-51	GRDX	Homo sapiens	63-66
1384262-2	1992	The M-protein bound to gangliosides with polysialosyl residue, such as GD1b, GD3, GT1b, GT3, GQ1b, and GQ1c.	Gangliosides	23-35	myomesin 2	Homo sapiens	4-13
1384262-5	1992	described a similar case in which sensory symptoms were associated with IgM M-protein reacting with gangliosides containing a disialosyl group, such as GD3, GD1b, and GT1b, but not GM3 and GD1a.	Gangliosides	100-112	myomesin 2	Homo sapiens	76-85
1386984-0	1992	Ganglioside GM2 levels in human melanoma cells: inverse correlation with lysosomal beta-hexosaminidase A activity.	Gangliosides	0-11	hexosaminidase subunit alpha	Homo sapiens	83-104
1627599-3	1992	These five MAbs, designated GMR6, GMB28, GMB16, GMR17, and GMR11 reacted strongly with the gangliosides GM3, GM2, GM1, GD1a, and GT1a, respectively, that were used as immunogens.	Gangliosides	91-103	granulocyte macrophage antigen 3	Mus musculus	104-107
1627599-3	1992	These five MAbs, designated GMR6, GMB28, GMB16, GMR17, and GMR11 reacted strongly with the gangliosides GM3, GM2, GM1, GD1a, and GT1a, respectively, that were used as immunogens.	Gangliosides	91-103	coenzyme Q10A	Mus musculus	114-117
1627599-4	1992	Three MAbs, GMB28 (anti-GM2), GMB16 (anti-GM1), and GMR11 (anti-GT1a) showed highly restricted binding specificities, reacting only with the immunizing ganglioside.	Gangliosides	152-163	cytochrome b5 domain containing 2	Mus musculus	24-27
1627599-4	1992	Three MAbs, GMB28 (anti-GM2), GMB16 (anti-GM1), and GMR11 (anti-GT1a) showed highly restricted binding specificities, reacting only with the immunizing ganglioside.	Gangliosides	152-163	coenzyme Q10A	Mus musculus	42-45
1386984-3	1992	The objective of the present studies is to determine if the elevated levels of gangliosides, particularly GM2, correlate with the activity of Hex A in cultured melanoma cells.	Gangliosides	79-91	hexosaminidase subunit alpha	Homo sapiens	142-147
1601853-8	1992	261, 5625-5630), and this is the first description of the occurrence of the ganglioside with the branched structure with two N-acetyllactosamines linked to lactosylceramide via beta 1-6 and beta 1-3 in human linked to lactosylceramide via beta 1-6 and beta 1-3 in human tissues.	Gangliosides	76-87	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	177-185
1324094-5	1992	Studies on the cell surface gangliosides revealed that unlike the proliferating cells, the GM3Ab-mediated differentiated cells contained higher gangliosides in addition to GM3 and GM2 gangliosides.	Gangliosides	28-40	granulocyte macrophage antigen 3	Mus musculus	91-94
1324094-5	1992	Studies on the cell surface gangliosides revealed that unlike the proliferating cells, the GM3Ab-mediated differentiated cells contained higher gangliosides in addition to GM3 and GM2 gangliosides.	Gangliosides	144-156	granulocyte macrophage antigen 3	Mus musculus	91-94
1332291-1	1992	In hippocampal slices of rats was studied the influence of different gangliosides on the dynamics of development of long-term post-tetanic potentiation (LPTP) in the pyramidal cell layer of the CA3 area at stimulation of the mossy fibers.	Gangliosides	69-81	carbonic anhydrase 3	Rattus norvegicus	194-197
1376299-2	1992	In order to determine the frequency of ganglioside GD3 in patients with metastatic malignant melanoma for further therapeutic trials, GD3 ganglioside expression was determined in 119 tissue samples.	Gangliosides	39-50	GRDX	Homo sapiens	51-54
1376299-5	1992	All the antibodies tested recognize the ganglioside GD3, but vary in their cross-reactivity with other gangliosides.	Gangliosides	40-51	GRDX	Homo sapiens	52-55
1601853-8	1992	261, 5625-5630), and this is the first description of the occurrence of the ganglioside with the branched structure with two N-acetyllactosamines linked to lactosylceramide via beta 1-6 and beta 1-3 in human linked to lactosylceramide via beta 1-6 and beta 1-3 in human tissues.	Gangliosides	76-87	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	190-198
1601853-8	1992	261, 5625-5630), and this is the first description of the occurrence of the ganglioside with the branched structure with two N-acetyllactosamines linked to lactosylceramide via beta 1-6 and beta 1-3 in human linked to lactosylceramide via beta 1-6 and beta 1-3 in human tissues.	Gangliosides	76-87	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	239-247
1601853-8	1992	261, 5625-5630), and this is the first description of the occurrence of the ganglioside with the branched structure with two N-acetyllactosamines linked to lactosylceramide via beta 1-6 and beta 1-3 in human linked to lactosylceramide via beta 1-6 and beta 1-3 in human tissues.	Gangliosides	76-87	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	252-260
1577868-0	1992	Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth.	Gangliosides	0-11	neural cell adhesion molecule 1	Rattus norvegicus	26-55
1632864-6	1992	The re-increase of total serum gangliosides was strictly correlated to that of LDL-cholesterol and apolipoprotein B.	Gangliosides	31-43	apolipoprotein B	Homo sapiens	99-115
1632864-8	1992	Our results indicate that gangliosides are excreted into the serum along with nascent apolipoprotein B-containing lipoproteins, which are of hepatic origin.	Gangliosides	26-38	apolipoprotein B	Homo sapiens	86-102
1610549-1	1992	This experiment was conducted in order to investigate whether expression of gangliosides on islet cell surface in vitro is influenced by cytokines, especially interleukin 1.	Gangliosides	76-88	interleukin 1 alpha	Homo sapiens	159-172
1577868-0	1992	Ganglioside modulation of neural cell adhesion molecule and N-cadherin-dependent neurite outgrowth.	Gangliosides	0-11	cadherin 2	Rattus norvegicus	60-70
1559567-6	1992	Although 17 days of GM1 injections did not affect astrocyte morphology within the NBM, ganglioside treatment reduced the number of GFAP-positive cells after electrolytic but not after ibotenic lesions.	Gangliosides	87-98	glial fibrillary acidic protein	Rattus norvegicus	131-135
1315772-0	1992	Mechanism for ganglioside-mediated modulation of a calmodulin-dependent enzyme.	Gangliosides	14-25	calmodulin 1	Homo sapiens	51-61
1315772-1	1992	Modulation of calmodulin-dependent cyclic nucleotide phosphodiesterase activity through binding of gangliosides to calmodulin and the enzyme.	Gangliosides	99-111	calmodulin 1	Homo sapiens	14-24
1315772-1	1992	Modulation of calmodulin-dependent cyclic nucleotide phosphodiesterase activity through binding of gangliosides to calmodulin and the enzyme.	Gangliosides	99-111	phosphodiesterase 3B	Homo sapiens	35-70
1315772-1	1992	Modulation of calmodulin-dependent cyclic nucleotide phosphodiesterase activity through binding of gangliosides to calmodulin and the enzyme.	Gangliosides	99-111	calmodulin 1	Homo sapiens	115-125
1315772-2	1992	Gangliosides were recently shown to bind to calmodulin (Higashi, H., Omori, A., and Yamagata, T. (1992) J. Biol.	Gangliosides	0-12	calmodulin 1	Homo sapiens	44-54
1315772-5	1992	This prompted us to investigate the effects of gangliosides on the calmodulin-dependent enzyme, cyclic nucleotide phosphodiesterase.	Gangliosides	47-59	calmodulin 1	Homo sapiens	67-77
1315772-5	1992	This prompted us to investigate the effects of gangliosides on the calmodulin-dependent enzyme, cyclic nucleotide phosphodiesterase.	Gangliosides	47-59	phosphodiesterase 3B	Homo sapiens	96-131
1315772-6	1992	Several species of gangliosides competitively inhibited calmodulin-stimulated phosphodiesterase activity, with GD1b, GT1b, and GD1a being noted to do so particularly (group 1).	Gangliosides	19-31	calmodulin 1	Homo sapiens	56-66
1315772-11	1992	Ganglioside-dependent modulation of calmodulin-dependent phosphodiesterase activity is thus shown to be due to interactions of gangliosides with both calmodulin and the enzyme, and consequently, ganglioside-calmodulin binding is likely the mechanism for regulation of the enzyme.	Gangliosides	0-11	calmodulin 1	Homo sapiens	36-46
1315772-11	1992	Ganglioside-dependent modulation of calmodulin-dependent phosphodiesterase activity is thus shown to be due to interactions of gangliosides with both calmodulin and the enzyme, and consequently, ganglioside-calmodulin binding is likely the mechanism for regulation of the enzyme.	Gangliosides	0-11	calmodulin 1	Homo sapiens	150-160
1315772-11	1992	Ganglioside-dependent modulation of calmodulin-dependent phosphodiesterase activity is thus shown to be due to interactions of gangliosides with both calmodulin and the enzyme, and consequently, ganglioside-calmodulin binding is likely the mechanism for regulation of the enzyme.	Gangliosides	0-11	calmodulin 1	Homo sapiens	150-160
1315772-11	1992	Ganglioside-dependent modulation of calmodulin-dependent phosphodiesterase activity is thus shown to be due to interactions of gangliosides with both calmodulin and the enzyme, and consequently, ganglioside-calmodulin binding is likely the mechanism for regulation of the enzyme.	Gangliosides	127-139	calmodulin 1	Homo sapiens	36-46
1315772-11	1992	Ganglioside-dependent modulation of calmodulin-dependent phosphodiesterase activity is thus shown to be due to interactions of gangliosides with both calmodulin and the enzyme, and consequently, ganglioside-calmodulin binding is likely the mechanism for regulation of the enzyme.	Gangliosides	127-139	calmodulin 1	Homo sapiens	150-160
1315772-11	1992	Ganglioside-dependent modulation of calmodulin-dependent phosphodiesterase activity is thus shown to be due to interactions of gangliosides with both calmodulin and the enzyme, and consequently, ganglioside-calmodulin binding is likely the mechanism for regulation of the enzyme.	Gangliosides	127-139	calmodulin 1	Homo sapiens	150-160
1521926-9	1992	These results suggest that glycosylation of glycoprotein and/or gangliosides might play an important role in the formation of a functional high-affinity IL-2 receptor complex in CT6 cells.	Gangliosides	64-76	interleukin 2	Mus musculus	153-157
1577817-1	1992	Binding of gangliosides to calmodulin in the presence of calcium.	Gangliosides	11-23	calmodulin	Bos taurus	27-37
1577817-5	1992	Modification of the Lys94 residue of calmodulin by biotinylation drastically reduced the capacity for ganglioside binding.	Gangliosides	102-113	calmodulin	Bos taurus	37-47
1577817-6	1992	Ganglioside GD1b caused a blue shift and increase in intensity of the fluorescence emission spectrum of dansyl-calmodulin in the presence of Ca2+.	Gangliosides	0-11	calmodulin	Bos taurus	111-121
1577817-8	1992	Gangliosides are thus shown to specifically bind to calmodulin, and this binding may be a general mechanism for regulating calmodulin-dependent enzymes with consequent cellular response, such as cell differentiation.	Gangliosides	0-12	calmodulin	Bos taurus	52-62
1577817-8	1992	Gangliosides are thus shown to specifically bind to calmodulin, and this binding may be a general mechanism for regulating calmodulin-dependent enzymes with consequent cellular response, such as cell differentiation.	Gangliosides	0-12	calmodulin	Bos taurus	123-133
1373001-0	1992	Preferential interaction of the CD4+29+/45RA-subset of human CD4+ T lymphocytes with an antibody against the cell-membrane ganglioside GD3.	Gangliosides	123-134	CD4 molecule	Homo sapiens	32-35
1548486-2	1992	The activities of four sialyltransferases (GM3, GD3, GD1a, and GT1a synthase) involved in ganglioside biosynthesis were assayed in the collected fractions.	Gangliosides	90-101	GRDX	Homo sapiens	48-51
1373001-0	1992	Preferential interaction of the CD4+29+/45RA-subset of human CD4+ T lymphocytes with an antibody against the cell-membrane ganglioside GD3.	Gangliosides	123-134	CD4 molecule	Homo sapiens	61-64
1371788-2	1992	We have studied the impact of gangliosides on the expression of TNF in blood monocytes and in the monocytic cell line Mono Mac 6.	Gangliosides	30-42	tumor necrosis factor	Homo sapiens	64-67
1371788-3	1992	Although under standard culture conditions, bovine brain gangliosides (100 micrograms/ml) suppressed LPS-stimulated TNF production 5-fold in PBMC and 10-fold in Mono Mac 6 cells, suppression was more efficient under serum-free conditions.	Gangliosides	57-69	tumor necrosis factor	Bos taurus	116-119
1347707-1	1992	We have previously shown that 3F8, a murine IgG3, monoclonal antibody (MoAb) specific for the ganglioside GD2, mediates tumor cell kill in vitro and in vivo.	Gangliosides	94-105	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	44-48
1371788-4	1992	Looking at highly purified gangliosides, GD3, GD1a, GM3, GM2, and GM1 were all effective in reducing TNF production in PBMC, and in Mono Mac 6 by factor 10 to 50.	Gangliosides	27-39	GRDX	Homo sapiens	41-44
1371788-4	1992	Looking at highly purified gangliosides, GD3, GD1a, GM3, GM2, and GM1 were all effective in reducing TNF production in PBMC, and in Mono Mac 6 by factor 10 to 50.	Gangliosides	27-39	tumor necrosis factor	Homo sapiens	101-104
1371788-6	1992	Gangliosides appear to act at an early step of activation in that TNF transcripts were reduced and the mobilization of the nuclear factor kappa B was blocked.	Gangliosides	0-12	tumor necrosis factor	Homo sapiens	66-69
1371788-9	1992	Finally, when using Staphylococcus aureus or platelet activating factor as a stimulus, gangliosides were able to suppress TNF production in Mono Mac 6 cells by factor 5 to 10, as well.	Gangliosides	87-99	tumor necrosis factor	Homo sapiens	122-125
1371788-11	1992	Taken together, our data demonstrate that TNF gene expression in monocytes induced by different types of stimuli can be blocked by gangliosides at an early step of signal transduction.	Gangliosides	131-143	tumor necrosis factor	Homo sapiens	42-45
1735456-3	1992	Treated fibroblasts contained less ganglioside NeuAc alpha 2-3Gal beta 1-4GlcCer (GM3), presumably due to neuraminidase-catalyzed hydrolysis to lactosylceramide.	Gangliosides	35-46	neuraminidase 1	Homo sapiens	106-119
1624212-8	1992	These studies provide new insight on the mechanism of immunomodulation by cholera toxin, and CTB should provide a useful tool for further understanding the role of gangliosides in cellular immune responses.	Gangliosides	164-176	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	93-96
1543718-1	1992	Galactosylceramide (GalCer) and the ganglioside, GM1, were 2H-labelled at C-6 (the hydroxymethyl moiety) of their single terminal galactosyl residues.	Gangliosides	36-47	complement C6	Homo sapiens	74-77
1727711-5	1992	GM3 is a ganglioside fraction expressed in female and male NOD mice and not in the C57BL/10 strain, whereas GD3 characterizes the C57BL/10 strain islets.	Gangliosides	9-20	granulocyte macrophage antigen 3	Mus musculus	0-3
1286626-9	1992	The results suggest that the polysialic acids in NCAM have more important roles in neurite outgrowth than gangliosides, since the composition and synthesis of gangliosides are not affected by cell seeding density.	Gangliosides	159-171	neural cell adhesion molecule 1	Rattus norvegicus	49-53
1551231-4	1992	Gangliosides were found to completely prevent the inhibition by K-252a of NGF-induced neurite regeneration and c-fos induction, and partially also that of protein kinase N activation.	Gangliosides	0-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	111-116
1628323-1	1992	We reported recently that two glycosphingolipids (GSLs), globoside (Gb4) and ganglioside GM3, colocalized with vimentin intermediate filaments of human umbilical vein endothelial cells.	Gangliosides	77-88	vimentin	Homo sapiens	111-119
1727711-6	1992	GM2-1 is the sole ganglioside fraction in the whole pancreas to clearly decrease with age in the NOD mouse, and diabetes onset in this strain is associated with a significant decrease in the expression of this component as well as of GM3, whereas other pancreatic ganglioside (GD3, GD1a, and GT1b) levels did not significantly decrease; no age-related ganglioside change was observed in the C57BL/10SnJ mouse.	Gangliosides	18-29	cerebellar degeneration-related protein 2-like	Mus musculus	0-5
1727711-6	1992	GM2-1 is the sole ganglioside fraction in the whole pancreas to clearly decrease with age in the NOD mouse, and diabetes onset in this strain is associated with a significant decrease in the expression of this component as well as of GM3, whereas other pancreatic ganglioside (GD3, GD1a, and GT1b) levels did not significantly decrease; no age-related ganglioside change was observed in the C57BL/10SnJ mouse.	Gangliosides	264-275	cerebellar degeneration-related protein 2-like	Mus musculus	0-5
1382491-3	1992	Specificity and affinity of nine antibodies of IgG3 isotype were evaluated by enzyme linked immunosorbent assay and thin layer chromatography with a panel of purified gangliosides.	Gangliosides	167-179	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	47-51
1382491-5	1992	Their affinity constants for ganglioside GD3 ranged from 4.7 x 10(6) to 2.3 x 10(8), with 2 x 10(7) for Mab R-24.	Gangliosides	29-40	GRDX	Homo sapiens	41-44
1727711-6	1992	GM2-1 is the sole ganglioside fraction in the whole pancreas to clearly decrease with age in the NOD mouse, and diabetes onset in this strain is associated with a significant decrease in the expression of this component as well as of GM3, whereas other pancreatic ganglioside (GD3, GD1a, and GT1b) levels did not significantly decrease; no age-related ganglioside change was observed in the C57BL/10SnJ mouse.	Gangliosides	264-275	cerebellar degeneration-related protein 2-like	Mus musculus	0-5
1727711-7	1992	Interestingly, the observed increased ICA binding in NOD islets is paralleled by the increased expression of GM2-1 islet ganglioside, and beta-cell destruction in NOD mice is associated with a significant decrease in the amount of this ganglioside in the pancreas.	Gangliosides	121-132	cerebellar degeneration-related protein 2-like	Mus musculus	109-114
1381802-1	1992	In vitro immunomodulatory properties of gangliosides have been well characterized such as the ganglioside-induced modulation of CD4 on T lymphocytes and inhibition of lectin-induced proliferative response of lymphocytes.	Gangliosides	40-51	CD4 antigen	Mus musculus	128-131
1729197-0	1992	Molecular genetic analysis of ganglioside GD1b-binding activity of Escherichia coli type IIa heat-labile enterotoxin by use of random and site-directed mutagenesis.	Gangliosides	30-41	colicin Ia immunity protein	Escherichia coli	89-92
1381802-1	1992	In vitro immunomodulatory properties of gangliosides have been well characterized such as the ganglioside-induced modulation of CD4 on T lymphocytes and inhibition of lectin-induced proliferative response of lymphocytes.	Gangliosides	40-52	CD4 antigen	Mus musculus	128-131
1381802-4	1992	Murine spleen cells that were treated with a ganglioside mixture (GS) purified from bovine brain exhibited a marked decrease in CD4 expression, while CD8 expression was slightly suppressed.	Gangliosides	45-56	CD4 molecule	Bos taurus	128-131
1661775-1	1991	Simultaneous profile determination and quantification of human cerebrospinal fluid (CSF) gangliosides in various neurologic diseases (n = 71) was examined.	Gangliosides	89-101	colony stimulating factor 2	Homo sapiens	84-87
14621872-1	1992	In vitro gangliosides exert inhibitory effects on cellular immune responses, largely relying on an impairment of the IL-2/IL-2 receptor interaction.	Gangliosides	9-21	interleukin 2	Rattus norvegicus	117-121
14621872-1	1992	In vitro gangliosides exert inhibitory effects on cellular immune responses, largely relying on an impairment of the IL-2/IL-2 receptor interaction.	Gangliosides	9-21	interleukin 2	Rattus norvegicus	122-126
1660040-0	1991	Tumor-cell killing by MAbs against fucosyl GM1, a ganglioside antigen associated with small-cell lung carcinoma.	Gangliosides	50-61	coenzyme Q10A	Mus musculus	43-46
1660040-1	1991	Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in vivo.	Gangliosides	47-58	coenzyme Q10A	Mus musculus	67-70
1660040-1	1991	Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in vivo.	Gangliosides	47-58	coenzyme Q10A	Mus musculus	76-79
1810468-3	1991	While their physiological function is largely unclear, gangliosides expressed by cancer cells, e.g. GD3, GD2 and GM2 in malignant melanoma, have proven to be suitable targets for passive immunotherapy with monoclonal antibodies and for active immunotherapy with vaccines.	Gangliosides	55-67	GRDX	Homo sapiens	100-103
1841683-0	1991	Structural studies of gangliosides from the YAC-1 mouse lymphoma cell line by immunological detection and fast atom bombardment mass spectrometry.	Gangliosides	22-34	ADP-ribosyltransferase 1	Mus musculus	44-49
1538824-1	1992	The content and composition of gangliosides in cultures enriched in granule neurones and in astrocytes from rat cerebellum (P6-8) showed marked differences: astrocytes contained less than 10% of the amount of granule neurones and the profile was dominated by simple gangliosides with lactosyl ceramide backbone, while gangliosides of the "b" series, which constitute about 40% in nerve cells, were virtually undetectable.	Gangliosides	31-43	KH RNA binding domain containing, signal transduction associated 1	Rattus norvegicus	124-128
21551654-2	1992	Ganglioside GMl counteracts these effects in a dose-responsive fashion between 10 nM and 50 muM.	Gangliosides	0-11	glycosylphosphatidylinositol anchored molecule like	Rattus norvegicus	12-15
1376009-5	1992	APG1 reacted with only two bands near GM2 and GD2 of the ganglioside fraction on a thin-layer chromatography plate, but it did not react with any of the known gangliosides of the ganglioside series including GM2 and GD2.	Gangliosides	57-68	heat shock protein family A (Hsp70) member 4 like	Homo sapiens	0-4
1668531-1	1991	Several properties of the exchangeable amide protons of the ganglioside GM2 were studied in detail by 1H-NMR spectroscopy in fully deuterated dimethylsulfoxide [2H6]DMSO/2% H2O, and compared with data obtained for the simpler constituent glycosphingolipids GA2 and GM3.	Gangliosides	60-71	electron transfer flavoprotein subunit alpha	Homo sapiens	257-260
1774957-1	1991	The glycosphingolipids GD3, GM3, and alpha 2, 3-sialosylparagloboside (SPG) are major gangliosides of lymphoid leukemia cells.	Gangliosides	86-98	GRDX	Homo sapiens	23-26
1774957-10	1991	The results show that comparative staining of T-ALL and pre-B-ALL cells with both anti-GD3 and anti-GM3/SPG antibodies results in a further subclassification of ALL and provides a quantitative assessment of the expression of tumor-associated gangliosides on the blasts of this disease.	Gangliosides	242-254	GRDX	Homo sapiens	87-90
1806326-4	1991	Both the primary tumour and its cultured cells contained GM3 and GD3 as major gangliosides.	Gangliosides	78-90	GRDX	Homo sapiens	65-68
1661775-7	1991	Significant alterations of the CSF ganglioside profile, with an increase in less polar gangliosides, GM3 and GD3, correlated with the blood-brain barrier dysfunction (CSF hemorrhages, compressive syndrome), or some malignant processes (metastatic brain melanoma).	Gangliosides	35-46	colony stimulating factor 2	Homo sapiens	167-170
1661775-7	1991	Significant alterations of the CSF ganglioside profile, with an increase in less polar gangliosides, GM3 and GD3, correlated with the blood-brain barrier dysfunction (CSF hemorrhages, compressive syndrome), or some malignant processes (metastatic brain melanoma).	Gangliosides	87-99	colony stimulating factor 2	Homo sapiens	31-34
1661775-8	1991	A statistically significant increase in the content of total CSF gangliosides was found in the following groups of patients as compared to controls: (1) ischemic cerebrovascular accident (CVI) with good outcome (P less than 0.02); (2) peripheral neuropathy and polyneuropathy (P less than 0.001) and (3) intravertebral discopathy (P less than 0.05).	Gangliosides	65-77	colony stimulating factor 2	Homo sapiens	61-64
1661775-9	1991	A significant decrease in the content of total CSF gangliosides was found in CVI group with lethal outcome (P less than 0.05).	Gangliosides	51-63	colony stimulating factor 2	Homo sapiens	47-50
1919364-9	1991	Inhibition of LPS-induced mitogenesis was present even if gangliosides were removed from the extracellular environment after 15-60 min of incubation prior to the addition of LPS.	Gangliosides	58-70	toll-like receptor 4	Mus musculus	14-17
1661775-2	1991	Gangliosides were extracted with methanol/chloroform from clinically available amounts of CSF (4-5 ml), then separated and quantified by high-performance thin-layer chromatography (HPTLC) and direct densitometry.	Gangliosides	0-12	colony stimulating factor 2	Homo sapiens	90-93
1661775-7	1991	Significant alterations of the CSF ganglioside profile, with an increase in less polar gangliosides, GM3 and GD3, correlated with the blood-brain barrier dysfunction (CSF hemorrhages, compressive syndrome), or some malignant processes (metastatic brain melanoma).	Gangliosides	35-46	colony stimulating factor 2	Homo sapiens	31-34
1834320-2	1991	It results from mutations of the HEXA gene encoding the alpha subunit of beta-hexosaminidase, producing a destructive ganglioside accumulation in lysosomes, principally in neurons.	Gangliosides	118-129	hexosaminidase subunit alpha	Homo sapiens	33-37
1744419-7	1991	Alterations of hepatic enzyme activities indicate that GL2 and GM3 synthase regulate total hepatic ganglioside content.	Gangliosides	99-110	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	63-75
1814411-12	1991	In addition, in Alzheimer"s disease we found simple gangliosides (GN2, GM3) to be elevated in the frontal and parietal cortex, which might correlate accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.	Gangliosides	52-64	glycogenin 2	Homo sapiens	66-69
1814411-12	1991	In addition, in Alzheimer"s disease we found simple gangliosides (GN2, GM3) to be elevated in the frontal and parietal cortex, which might correlate accelerated lysosomal degradation of gangliosides and/or astrogliosis occurring during neuronal death.	Gangliosides	186-198	glycogenin 2	Homo sapiens	66-69
1761792-0	1991	Gangliosides inhibit the proliferation of human T cells stimulated with interleukin-4 or interleukin-2.	Gangliosides	0-12	interleukin 4	Homo sapiens	72-85
1726779-5	1991	These results indicate that the increased synthesis of both gangliosides, in other words, the activation of N-acetylgalactosaminyltransferase, is associated with the mitogen-induced proliferation.	Gangliosides	60-72	beta-1,4-N-acetyl-galactosaminyl transferase 2	Mus musculus	108-141
1761792-9	1991	These findings suggest that gangliosides may play an immunomodulatory role by interfering with IL-4 or IL-2-driven proliferation of human T cells.	Gangliosides	28-40	interleukin 4	Homo sapiens	95-99
1761792-9	1991	These findings suggest that gangliosides may play an immunomodulatory role by interfering with IL-4 or IL-2-driven proliferation of human T cells.	Gangliosides	28-40	interleukin 2	Homo sapiens	103-107
1761792-0	1991	Gangliosides inhibit the proliferation of human T cells stimulated with interleukin-4 or interleukin-2.	Gangliosides	0-12	interleukin 2	Homo sapiens	89-102
1761792-3	1991	Bovine brain gangliosides inhibited the proliferation of human T cells activated by PMA + IL-4 or PMA + IL-2.	Gangliosides	13-25	interleukin 4	Homo sapiens	90-94
1761792-3	1991	Bovine brain gangliosides inhibited the proliferation of human T cells activated by PMA + IL-4 or PMA + IL-2.	Gangliosides	13-25	interleukin 2	Homo sapiens	104-108
1761792-5	1991	PMA + IL-2 stimulation was more sensitive to the inhibitory effects of gangliosides (I50 = 77.2 microM) than PMA + IL-4 stimulation (I50 = 105.9 microM).	Gangliosides	71-83	interleukin 2	Homo sapiens	6-10
1943499-6	1991	Sialidase, beta-galactosidase, beta-glucosidase, and beta-hexosaminidase, which are involved in the catabolism of gangliosides, showed higher activities in all the regions of undernourished pups, suggesting that these enzymes may play a role in maintaining the porportions of various ganglioside fractions.	Gangliosides	114-126	galactosidase, beta 1	Rattus norvegicus	11-29
2050106-6	1991	In conclusion, sialoadhesin specifically recognizes the oligosaccharide sequence Neu5Ac alpha 2----3Gal beta 1----3GalNAc in either sialoglycoproteins or gangliosides.	Gangliosides	154-166	sialic acid binding Ig-like lectin 1, sialoadhesin	Mus musculus	15-27
1651376-0	1991	Interaction of ganglioside GM1 with the B subunit of cholera toxin modulates growth and differentiation of neuroblastoma N18 cells.	Gangliosides	15-26	coenzyme Q10A	Mus musculus	27-30
1943499-6	1991	Sialidase, beta-galactosidase, beta-glucosidase, and beta-hexosaminidase, which are involved in the catabolism of gangliosides, showed higher activities in all the regions of undernourished pups, suggesting that these enzymes may play a role in maintaining the porportions of various ganglioside fractions.	Gangliosides	114-126	O-GlcNAcase	Rattus norvegicus	53-72
1943499-6	1991	Sialidase, beta-galactosidase, beta-glucosidase, and beta-hexosaminidase, which are involved in the catabolism of gangliosides, showed higher activities in all the regions of undernourished pups, suggesting that these enzymes may play a role in maintaining the porportions of various ganglioside fractions.	Gangliosides	114-125	galactosidase, beta 1	Rattus norvegicus	11-29
1943499-6	1991	Sialidase, beta-galactosidase, beta-glucosidase, and beta-hexosaminidase, which are involved in the catabolism of gangliosides, showed higher activities in all the regions of undernourished pups, suggesting that these enzymes may play a role in maintaining the porportions of various ganglioside fractions.	Gangliosides	114-125	O-GlcNAcase	Rattus norvegicus	53-72
1921517-3	1991	The ganglioside contents in the whole brains of SAM-P/8 and -R/1 were at almost constant level from 0.5 to 6 months, but decreased thereafter until senescence to about 80% of the levels reached at the younger ages.	Gangliosides	4-15	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble	Mus musculus	48-64
1676513-1	1991	We have investigated the ability of exogenous gangliosides to modulate nerve growth factor (NGF) signal transduction in PC12 cells.	Gangliosides	46-58	nerve growth factor	Rattus norvegicus	71-90
1676513-1	1991	We have investigated the ability of exogenous gangliosides to modulate nerve growth factor (NGF) signal transduction in PC12 cells.	Gangliosides	46-58	nerve growth factor	Rattus norvegicus	92-95
1943708-4	1991	Amino acid substitutions that caused decreased binding of mutant CT-B to ganglioside GM1 and abolished toxicity included negatively charged or large hydrophobic residues for Gly-33 and negatively or positively charged residues for Trp-88.	Gangliosides	73-84	phosphate cytidylyltransferase 1B, choline	Homo sapiens	65-69
1921517-4	1991	Upon aging, the ganglioside compositions changed with an increase of GM1, and decreases of GD1a, GD1b and GT1b in both strains (GT1b greater than GD1a greater than GD1b).	Gangliosides	16-27	coenzyme Q10A	Mus musculus	69-72
1921517-5	1991	A minor component, GM3 was two to four fold higher in the molecular distributions of the whole brain gangliosides of SAM-P/8 than those of -R/1 at any age examined throughout the life span.	Gangliosides	101-113	granulocyte macrophage antigen 3	Mus musculus	19-22
1645342-27	1991	These studies indicate that ganglioside GM3, but not its deacetylated analogue, can affect EGF receptor kinase activity in intact membranes.	Gangliosides	28-39	epidermal growth factor	Homo sapiens	91-94
1716576-2	1991	Total gangliosides (10 micrograms/paw) inhibited the edema produced by the injection of bee venom phospholipase A2 (5 micrograms/paw) when the lipids were co-injected or injected 15 min before the phospholipase A2.	Gangliosides	6-18	phospholipase A2 group IB	Rattus norvegicus	98-114
1716576-2	1991	Total gangliosides (10 micrograms/paw) inhibited the edema produced by the injection of bee venom phospholipase A2 (5 micrograms/paw) when the lipids were co-injected or injected 15 min before the phospholipase A2.	Gangliosides	6-18	phospholipase A2 group IB	Rattus norvegicus	197-213
1716576-7	1991	Gangliosides inhibited the production of mediators of inflammation only when they were incubated with these cells before the stimulation with phospholipase A2 or carrageenin.	Gangliosides	0-12	phospholipase A2 group IB	Rattus norvegicus	142-158
1645342-0	1991	Effects of gangliosides GM3 and De-N-acetyl GM3 on epidermal growth factor receptor kinase activity and cell growth.	Gangliosides	11-23	epidermal growth factor receptor	Homo sapiens	51-83
1645342-4	1991	261, 2434-2440) that ganglioside GM3 inhibited epidermal growth factor (EGF)-stimulated phosphorylation of the EGF receptor in Triton X-100-treated preparations of human epidermoid carcinoma (A431) cell membranes.	Gangliosides	21-32	granulocyte macrophage antigen 3	Mus musculus	33-36
1645342-4	1991	261, 2434-2440) that ganglioside GM3 inhibited epidermal growth factor (EGF)-stimulated phosphorylation of the EGF receptor in Triton X-100-treated preparations of human epidermoid carcinoma (A431) cell membranes.	Gangliosides	21-32	epidermal growth factor	Homo sapiens	47-70
1645342-4	1991	261, 2434-2440) that ganglioside GM3 inhibited epidermal growth factor (EGF)-stimulated phosphorylation of the EGF receptor in Triton X-100-treated preparations of human epidermoid carcinoma (A431) cell membranes.	Gangliosides	21-32	epidermal growth factor	Homo sapiens	72-75
1645342-4	1991	261, 2434-2440) that ganglioside GM3 inhibited epidermal growth factor (EGF)-stimulated phosphorylation of the EGF receptor in Triton X-100-treated preparations of human epidermoid carcinoma (A431) cell membranes.	Gangliosides	21-32	epidermal growth factor	Homo sapiens	111-114
1647206-2	1991	This elevated level of GM2 contrasted with the reports of many other investigators who had often observed decreased levels of GM2 and a simplification of ganglioside pattern in various non-neural rodent cell lines.	Gangliosides	154-165	cytochrome b5 domain containing 2	Mus musculus	23-26
1647206-3	1991	In order to determine if the increase in GM2 in the transformed human brain cells would also be found in transformed rodent brain cells, we analyzed ganglioside changes after transformation in mouse brain cell lines and observed the increase in GM3 and low levels or lack of GM2 usually noted in rodent SV-40 transformed cell lines.	Gangliosides	149-160	cytochrome b5 domain containing 2	Mus musculus	41-44
1645342-6	1991	In contrast, a modified ganglioside, de-N-acetyl GM3, enhanced the EGF-dependent tyrosine kinase activity of the EGF receptor.	Gangliosides	24-35	granulocyte macrophage antigen 3	Mus musculus	49-52
1757223-6	1991	Moreover, preliminary data reported show a protective effect of ganglioside treatment on endothelin-1 lesion of rat striatum.	Gangliosides	64-75	endothelin 1	Rattus norvegicus	89-101
1645342-6	1991	In contrast, a modified ganglioside, de-N-acetyl GM3, enhanced the EGF-dependent tyrosine kinase activity of the EGF receptor.	Gangliosides	24-35	epidermal growth factor	Homo sapiens	67-70
1645342-6	1991	In contrast, a modified ganglioside, de-N-acetyl GM3, enhanced the EGF-dependent tyrosine kinase activity of the EGF receptor.	Gangliosides	24-35	epidermal growth factor	Homo sapiens	113-116
1645342-15	1991	We also demonstrate that ganglioside GM3 inhibited EGF-stimulated growth of transfected murine fibroblasts (3T3) that express the gene for human EGF receptor (Velu, T. J., Beguinot, L., Vass, W. C., Zhang, K., Pastan, I., and Lowy, D. R. (1989) J.	Gangliosides	25-36	granulocyte macrophage antigen 3	Mus musculus	37-40
1645342-15	1991	We also demonstrate that ganglioside GM3 inhibited EGF-stimulated growth of transfected murine fibroblasts (3T3) that express the gene for human EGF receptor (Velu, T. J., Beguinot, L., Vass, W. C., Zhang, K., Pastan, I., and Lowy, D. R. (1989) J.	Gangliosides	25-36	epidermal growth factor	Mus musculus	51-54
1645342-15	1991	We also demonstrate that ganglioside GM3 inhibited EGF-stimulated growth of transfected murine fibroblasts (3T3) that express the gene for human EGF receptor (Velu, T. J., Beguinot, L., Vass, W. C., Zhang, K., Pastan, I., and Lowy, D. R. (1989) J.	Gangliosides	25-36	epidermal growth factor	Homo sapiens	145-148
1645342-27	1991	These studies indicate that ganglioside GM3, but not its deacetylated analogue, can affect EGF receptor kinase activity in intact membranes.	Gangliosides	28-39	granulocyte macrophage antigen 3	Mus musculus	40-43
1998961-5	1991	Ganglioside patterns of the two cell lines were similar, although gangliosides with N-glycolylneuraminic acid were increased in Had-1 cells compared with that in FM3A cells.	Gangliosides	66-78	solute carrier family 35 (UDP-galactose transporter), member A2	Mus musculus	128-133
1827496-0	1991	Gangliosides inhibit glucosylceramide synthase: a possible role in ganglioside therapy.	Gangliosides	0-12	UDP-glucose ceramide glucosyltransferase	Mus musculus	21-46
1827496-0	1991	Gangliosides inhibit glucosylceramide synthase: a possible role in ganglioside therapy.	Gangliosides	67-78	UDP-glucose ceramide glucosyltransferase	Mus musculus	21-46
2027012-2	1991	All the analyzed ganglioside mixtures contained the C18:1- and C18:0-long-chain bases, the latter covering 2-5% of the total long-chain base content.	Gangliosides	17-28	Bardet-Biedl syndrome 9	Homo sapiens	52-55
2027012-2	1991	All the analyzed ganglioside mixtures contained the C18:1- and C18:0-long-chain bases, the latter covering 2-5% of the total long-chain base content.	Gangliosides	17-28	Bardet-Biedl syndrome 9	Homo sapiens	63-66
1679352-0	1991	Development of tumor cell resistance to tumor necrosis factor cytolysis results in reduced fibronectin binding and altered ganglioside expression.	Gangliosides	123-134	tumor necrosis factor	Homo sapiens	40-61
1679352-7	1991	Gangliosides are non-integrin structures which can bind fibronectin, and there were also qualitative and quantitative differences in ganglioside expression with U937A having two to five times more than U937A/R.	Gangliosides	0-12	fibronectin 1	Homo sapiens	56-67
1883911-2	1991	It was found that in most cases GM3, GD3 and GM1 are predominant gangliosides, whereas several polar components are minor ones.	Gangliosides	65-77	GRDX	Homo sapiens	37-40
1900812-2	1991	The amounts of "a" pathway gangliosides (GM2, GM1 and GD1a) and those of the "b" pathway (GD3, GD2, GD1b and GT1b) differed according to the culture conditions.	Gangliosides	27-39	cytochrome b5 domain containing 2	Mus musculus	41-44
1999434-0	1991	A specific type of ganglioside as a modulator of insulin-dependent cell growth and insulin receptor tyrosine kinase activity.	Gangliosides	19-30	insulin	Homo sapiens	49-56
1999434-0	1991	A specific type of ganglioside as a modulator of insulin-dependent cell growth and insulin receptor tyrosine kinase activity.	Gangliosides	19-30	insulin	Homo sapiens	83-90
1999434-1	1991	Possible association of ganglioside-induced inhibition of insulin receptor function and monocytic differentiation induction in HL-60 cells.	Gangliosides	24-35	insulin receptor	Homo sapiens	58-74
2049855-2	1991	Gangliosides of the gangliotetraose series were individually determined with cholera toxin B-subunit (CT-B) and an anti CT-B monoclonal antibody after chromatography and sialidase hydrolysis to GM1 on high performance thin-layer plates.	Gangliosides	0-12	phosphate cytidylyltransferase 1B, choline	Homo sapiens	102-106
2000404-0	1991	Direct evidence that ganglioside is an integral component of the thyrotropin receptor.	Gangliosides	21-32	thyroid stimulating hormone receptor	Homo sapiens	65-85
2000404-1	1991	Gangliosides were extracted from purified human and porcine thyrotropin (TSH) receptors (TSH-R) and were detected by probing with an 125I-labeled sialic acid-specific lectin, Limax flavus agglutinin.	Gangliosides	0-12	thyroid stimulating hormone receptor	Homo sapiens	89-94
2000404-2	1991	Gangliosides copurified with human and porcine TSH-R migrated between monosialoganglioside GM1 and disialoganglioside GD1a.	Gangliosides	0-12	thyroid stimulating hormone receptor	Homo sapiens	47-52
2000404-3	1991	Ceramide glycanase digestion of the purified human TSH-R-associated glycolipid confirmed its ganglioside nature.	Gangliosides	93-104	thyroid stimulating hormone receptor	Homo sapiens	51-56
2000404-5	1991	These findings indicate that the human TSH-R contains ganglioside that belongs to the galactosyl(beta 1----3)-N-acetylgalactosaminyl (beta 1----4)-[N-acetylneuraminyl(alpha 2----3)]galactosyl(beta 1----4) glucosyl(beta 1----1)ceramide (GM1) family.	Gangliosides	54-65	thyroid stimulating hormone receptor	Homo sapiens	39-44
2000404-6	1991	Its intimate association with receptor protein implies a key role for ganglioside in the structure and function of the TSH-R.	Gangliosides	70-81	thyroid stimulating hormone receptor	Homo sapiens	119-124
1988158-0	1991	Effect of micellar and bilayer gangliosides on proliferation of interleukin-2-dependent lymphocytes.	Gangliosides	31-43	interleukin 2	Mus musculus	64-77
1988158-1	1991	Micellar gangliosides are potent inhibitors of the proliferation of the murine interleukin-2-dependent cell lines HT-2 and CTLL-2 in vitro.	Gangliosides	9-21	interleukin 2	Mus musculus	79-92
1988158-6	1991	Inhibition of DNA synthesis by gangliosides could be partially reversed by high concentrations of exogenous interleukin-2.	Gangliosides	31-43	interleukin 2	Mus musculus	108-121
1988158-7	1991	Gangliosides incorporated into lipid bilayers, both multilamellar liposomes and unilamellar vesicles, were also effective inhibitors of interleukin-2-induced proliferation.	Gangliosides	0-12	interleukin 2	Mus musculus	136-149
1988158-8	1991	Competition studies showed that both ganglioside micelles and lipid vesicles containing gangliosides prevented binding of 125I-interleukin-2 to high-affinity receptors on the lymphocyte surface.	Gangliosides	37-48	interleukin 2	Mus musculus	127-140
1988158-8	1991	Competition studies showed that both ganglioside micelles and lipid vesicles containing gangliosides prevented binding of 125I-interleukin-2 to high-affinity receptors on the lymphocyte surface.	Gangliosides	88-100	interleukin 2	Mus musculus	127-140
1988158-9	1991	We have recently shown that gangliosides, in both micelles and lipid bilayer vesicles, are able to bind interleukin-2 (J. W. K. Chu and F. J. Sharom, Biochim, Biophys.	Gangliosides	28-40	interleukin 2	Mus musculus	104-117
1988158-11	1991	Taken together, these results strongly suggest that inhibition of lymphocyte proliferation by gangliosides in micelles and vesicles arises as a direct result of competition between the glycolipids and high-affinity receptors for available interleukin-2.	Gangliosides	94-106	interleukin 2	Mus musculus	239-252
1993540-6	1991	The GM3 and GD3 content of the meningiomas belonging to the 2 groups revealed a significant correlation between amount and reciprocal ratio of these 2 gangliosides and cytogenetic data.	Gangliosides	151-163	GRDX	Homo sapiens	12-15
1993540-7	1991	Tumors with monosomy 22 had a higher content of ganglioside GD3 than samples without monosomy 22, where the main ganglioside was GM3.	Gangliosides	48-59	GRDX	Homo sapiens	60-63
1993540-9	1991	Considering the biosynthetic pathway of gangliosides, we hypothesize the involvement of a gene located on chromosome 22 in the regulation of the enzymes which catalyze either GD3 synthesis (sialyltransferase 2, SAT-2) or its degradation to GM3 (neuraminidase).	Gangliosides	40-52	GRDX	Homo sapiens	175-178
1993540-9	1991	Considering the biosynthetic pathway of gangliosides, we hypothesize the involvement of a gene located on chromosome 22 in the regulation of the enzymes which catalyze either GD3 synthesis (sialyltransferase 2, SAT-2) or its degradation to GM3 (neuraminidase).	Gangliosides	40-52	spermidine/spermine N1-acetyltransferase family member 2	Homo sapiens	211-216
1993540-9	1991	Considering the biosynthetic pathway of gangliosides, we hypothesize the involvement of a gene located on chromosome 22 in the regulation of the enzymes which catalyze either GD3 synthesis (sialyltransferase 2, SAT-2) or its degradation to GM3 (neuraminidase).	Gangliosides	40-52	neuraminidase 1	Homo sapiens	245-258
1909079-4	1991	These three antibodies also immunostained some neurons in Alzheimer"s brain, although their staining patterns were slightly different from one another; i.e., both diffuse and granular patterns were seen by the antibody to tau, but only granular pattern by the antibodies to C-series gangliosides and MAP5.	Gangliosides	283-295	microtubule associated protein tau	Homo sapiens	222-225
1993061-6	1991	The time course of changes in ganglioside biosynthesis suggests differential upregulation of GM3 synthase and GD3 synthase in regenerating livers.	Gangliosides	30-41	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Rattus norvegicus	93-105
1993061-6	1991	The time course of changes in ganglioside biosynthesis suggests differential upregulation of GM3 synthase and GD3 synthase in regenerating livers.	Gangliosides	30-41	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	110-122
1648861-0	1991	Ganglioside GD3 shedding by human gliomas.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
1648861-1	1991	The proportion of ganglioside GD3 increases in glioma tissue and GD3 content is correlated with malignancy of gliomas.	Gangliosides	18-29	GRDX	Homo sapiens	30-33
1648861-3	1991	Ganglioside GD3 was not detected in the sera of healthy donors and astrocytoma grade 2 patients.	Gangliosides	0-11	GRDX	Homo sapiens	12-15
1982895-11	1990	The expression of A2B5 gangliosides by 5-20% of GFAP-positive IPSB-18 cells, and their co-expression with the ganglioside GD3 identified by the LB1 monoclonal antibody, shows that cells with a similar phenotype to the type 1 and type 2 astrocytes of optic nerve are present in cultured gliomas, even after long term sequential passaging.	Gangliosides	23-35	glial fibrillary acidic protein	Homo sapiens	48-52
1751644-6	1991	In addition, frontal and parietal cortex also showed elevated concentration (nmol LBSA/g fresh weight) of simple gangliosides (GM2, GM3, GM4, GD3).	Gangliosides	113-125	GRDX	Homo sapiens	142-145
1751644-8	1991	However, elevation of simple gangliosides in frontal and parietal cortex may correlate with: (a) an accelerated lysosomal degradation of gangliosides occurring during neuronal death (GM2); (b) astrogliosis (GM3 and GD3); and (c) activation of oligodendrocytes (GM4).	Gangliosides	29-41	GRDX	Homo sapiens	215-218
2048136-9	1991	The binding was decreased by digestion of gangliosides with neuraminidase.	Gangliosides	42-54	neuraminidase 1	Bos taurus	60-73
2253196-1	1990	A combination of recombinant human interleukin 2 (rhIL-2) and mouse monoclonal antibody R24 (recognizing the ganglioside GD3) was evaluated in patients with metastatic melanoma in a phase I trial.	Gangliosides	109-120	GRDX	Homo sapiens	121-124
2102487-4	1990	GM3, GD3 and sialyl i- and I-type lactosaminylceramide are the gangliosides present in both FM3A and Had-1, although their presence in both cells is only in traces.	Gangliosides	63-75	solute carrier family 35 (UDP-galactose transporter), member A2	Mus musculus	101-106
1806363-1	1991	An activator protein that stimulates the enzymic hydrolysis of sialic acid from gangliosides by ganglioside sialidase was fractionated from human liver.	Gangliosides	80-92	neuraminidase 3	Homo sapiens	96-117
1670644-0	1991	Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides.	Gangliosides	167-179	CD4 molecule	Homo sapiens	38-41
1670644-0	1991	Glycosylphosphatidylinositol-anchored CD4/Thy-1 chimeric molecules serve as human immunodeficiency virus receptors in human, but not mouse, cells and are modulated by gangliosides.	Gangliosides	167-179	thymus cell antigen 1, theta	Mus musculus	42-47
1670644-4	1991	In addition, this molecule, like CD4, is down-modulated in its cell surface expression by exogenous gangliosides.	Gangliosides	100-112	CD4 molecule	Homo sapiens	33-36
1851273-3	1991	In addition, changes in the pattern of ganglioside composition were also observed in which the percentage of GM1 and GD3 in total gangliosides was significantly increased and, in contrast, the percentage of GD1a and GT1b was reduced.	Gangliosides	39-50	coenzyme Q10A	Mus musculus	109-112
1851273-3	1991	In addition, changes in the pattern of ganglioside composition were also observed in which the percentage of GM1 and GD3 in total gangliosides was significantly increased and, in contrast, the percentage of GD1a and GT1b was reduced.	Gangliosides	130-142	coenzyme Q10A	Mus musculus	109-112
1701352-0	1990	Enhanced expression of ganglioside GD3 in human and rat hepatocellular carcinoma cells and NIH 3T3 cells transfected with human tumor DNAs.	Gangliosides	23-34	GRDX	Homo sapiens	35-38
2098322-1	1990	GD3 is the ganglioside most abundantly expressed on the cell surface of human melanoma, and treatment with a monoclonal antibody recognizing GD3 has induced major responses in a small proportion of patients.	Gangliosides	11-22	GRDX	Homo sapiens	0-3
2098322-1	1990	GD3 is the ganglioside most abundantly expressed on the cell surface of human melanoma, and treatment with a monoclonal antibody recognizing GD3 has induced major responses in a small proportion of patients.	Gangliosides	11-22	GRDX	Homo sapiens	141-144
2230798-4	1990	A loss of chromosome 22, found in 56% of the specimens, was shown to be associated with an increase in the proportion of ganglioside GD3, with the ratio between mean values of GM3 and GD3 being approximately 1:1.	Gangliosides	121-132	GRDX	Homo sapiens	133-136
1982895-11	1990	The expression of A2B5 gangliosides by 5-20% of GFAP-positive IPSB-18 cells, and their co-expression with the ganglioside GD3 identified by the LB1 monoclonal antibody, shows that cells with a similar phenotype to the type 1 and type 2 astrocytes of optic nerve are present in cultured gliomas, even after long term sequential passaging.	Gangliosides	23-34	glial fibrillary acidic protein	Homo sapiens	48-52
2079981-1	1990	Increased serum titers of antibodies against the ganglioside GM1 or its carbohydrate epitope Gal(B1-3)GalNAc have been associated with motor neuron disease, motor neuropathies with or without conduction block and sensorimotor neuropathies, whereas low level titers are part of the normal immune repertoire and are present in control groups and in neonatal blood.	Gangliosides	49-60	galanin and GMAP prepropeptide	Homo sapiens	93-108
1700134-0	1990	Anti-idiotype monoclonal antibody carrying the internal image of ganglioside GM3.	Gangliosides	65-76	granulocyte macrophage antigen 3	Mus musculus	77-80
1700134-1	1990	Murine anti-idiotype monoclonal antibodies were generated against a human IgM monoclonal antibody (L612) that recognizes ganglioside GM3 on human melanoma.	Gangliosides	121-132	granulocyte macrophage antigen 3	Mus musculus	133-136
2096158-3	1990	In normal thyroids the major ganglioside was GD3 (44%) and GM3 was the second ganglioside (20%).	Gangliosides	29-40	GRDX	Homo sapiens	45-48
1702040-2	1990	The ganglioside GM1 potentiated the effect of extracellular Ca2+ by increasing further the number and length of the neurites formed in response to exogenous Ca2+.	Gangliosides	4-15	coenzyme Q10A	Mus musculus	16-19
2237955-6	1990	The results indicate that treatment with the ganglioside reduces postischemic secondary damage to the cortical circuitry (as indicated by significantly higher cortical electroencephalographic activity late after reperfusion) and limits neuronal loss in the CA1 region.	Gangliosides	45-56	carbonic anhydrase 1	Rattus norvegicus	257-260
1704123-7	1990	However, the functional cholera toxin receptor ganglioside Gm1 is resistant to neuraminidase treatment and periodate oxidation.	Gangliosides	47-58	neuraminidase 1	Homo sapiens	79-92
2237979-5	1990	Chlorpromazine and the gangliosides GM1 and AGF2 promote recovery from hypoxic depression of synaptic transmission in CA1.	Gangliosides	23-35	carbonic anhydrase 1	Rattus norvegicus	118-121
1979673-0	1990	A2B5 surface ganglioside binding distinguishes between two GFAP-positive clones from a human glioma-derived cell line.	Gangliosides	13-24	glial fibrillary acidic protein	Homo sapiens	59-63
2223793-0	1990	Interleukin-2 binds to gangliosides in micelles and lipid bilayers.	Gangliosides	23-35	interleukin 2	Homo sapiens	0-13
2223793-3	1990	We have thus investigated the interaction of IL-2 with gangliosides in micelles and lipid bilayers.	Gangliosides	55-67	interleukin 2	Homo sapiens	45-49
2223793-4	1990	Gel filtration FPLC showed that 125I-IL-2 can bind to micellar gangliosides in aqueous solution, and this interaction was strongly promoted by low concentrations of serum.	Gangliosides	63-75	interleukin 2	Homo sapiens	37-41
2223793-5	1990	Binding to ganglioside micelles was specific in that it required a native IL-2 molecule.	Gangliosides	11-22	interleukin 2	Homo sapiens	74-78
2223793-8	1990	Direct binding studies and gel filtration chromatography indicated that both multilamellar liposomes and 100 nm unilamellar vesicles containing gangliosides were able to interact with IL-2.	Gangliosides	144-156	interleukin 2	Homo sapiens	184-188
2223793-10	1990	The interaction of IL-2 with bilayer gangliosides was highly dependent on the bilayer lipid composition, but appeared independent of lipid phase state.	Gangliosides	37-49	interleukin 2	Homo sapiens	19-23
2223793-11	1990	These results suggest that gangliosides may be a physiologically relevant target for IL-2 binding.	Gangliosides	27-39	interleukin 2	Homo sapiens	85-89
2230814-0	1990	Nerve growth factor enhances the expression of the cholinergic-specific ganglioside Chol-1 in cocultures of rat septum and hippocampus.	Gangliosides	72-83	nerve growth factor	Rattus norvegicus	0-19
2167157-0	1990	Gangliosides and sialoglycoproteins carrying a rare blood group antigen determinant, Cad, associated with human cancers as detected by specific monoclonal antibodies.	Gangliosides	0-12	aconitate decarboxylase 1	Homo sapiens	85-88
2271553-1	1990	The individual properties and intermolecular organization of ganglioside GD3 and of two of its lactone forms (GD3Lactone I and GD3Lactone II) were studied in lipid monolayers.	Gangliosides	61-72	GRDX	Homo sapiens	73-76
2280488-2	1990	The binding of 125I-labeled CT to neuraminidase-treated human type B erythrocytes was most effectively inhibited by ganglioside GM1 among different inhibitors used.	Gangliosides	116-127	neuraminidase 1	Homo sapiens	34-47
2270748-3	1990	As compared to a reference group of 10 individuals (mean age 50 +/- 14 years), the CSF samples from 7 meningioma patients (mean age 55 +/- 12 years) were found to contain significantly increased concentrations of ganglioside GD3 [II3(NeuAc)2-LacCer], one of the major gangliosides in meningioma tissue specimens.	Gangliosides	268-280	GRDX	Homo sapiens	225-228
2167157-1	1990	Two murine monoclonal antibodies, 2A3D2 and 2D11E2 (both IgM), which are directed to the gangliosides and sialoglycoproteins related to a rare blood group antigen, Cad, were obtained by using a ganglioside mixture prepared from human hepatocellular carcinoma cells (PLC/PRF/5) as the immunogen.	Gangliosides	89-101	aconitate decarboxylase 1	Homo sapiens	164-167
2167157-4	1990	Beside gangliosides, both antibodies recognized the carbohydrate determinant carried by glycophorin A on very rare Cad-positive human RBC; the structure of which is GalNAc beta 1----4(NeuAc alpha 2----3)Gal beta 1----3(NeuAc alpha 2---- 6)GalNAc alpha 1----Ser/Thr.	Gangliosides	7-19	glycophorin A (MNS blood group)	Homo sapiens	88-101
2167157-1	1990	Two murine monoclonal antibodies, 2A3D2 and 2D11E2 (both IgM), which are directed to the gangliosides and sialoglycoproteins related to a rare blood group antigen, Cad, were obtained by using a ganglioside mixture prepared from human hepatocellular carcinoma cells (PLC/PRF/5) as the immunogen.	Gangliosides	89-100	aconitate decarboxylase 1	Homo sapiens	164-167
2176187-0	1990	Transmembrane signalling associated with ganglioside-induced CD4 modulation.	Gangliosides	41-52	CD4 molecule	Homo sapiens	61-64
2176187-1	1990	Ganglioside (GM1) treatment of CD4+ human CEM lymphoma cells stimulated transient phosphoinositide (PI) breakdown, production of inositol phosphates (IP), protein phosphorylation and rapid decrease of CD4 surface expression.	Gangliosides	0-11	CD4 molecule	Homo sapiens	31-34
2176187-1	1990	Ganglioside (GM1) treatment of CD4+ human CEM lymphoma cells stimulated transient phosphoinositide (PI) breakdown, production of inositol phosphates (IP), protein phosphorylation and rapid decrease of CD4 surface expression.	Gangliosides	0-11	CD4 molecule	Homo sapiens	201-204
2383025-0	1990	Tumor necrosis factor enhances GD3 ganglioside expression in cultured human melanocytes.	Gangliosides	35-46	GRDX	Homo sapiens	31-34
2391380-3	1990	As an approach to understanding the mechanism of this modulatory effect, we analysed the influence that gangliosides have on survival, growth, and migration of capillary endothelium when an angiogenesis factor like basic fibroblast growth factor (bFGF) was present in the culture medium.	Gangliosides	104-116	fibroblast growth factor 2	Bos taurus	215-245
2393674-2	1990	The C18-sphingenine was shown to be present in all ganglioside fractions; fraction GD1a contained, in addition, C20-sphingenine.	Gangliosides	51-62	Bardet-Biedl syndrome 9	Homo sapiens	4-7
2142159-2	1990	The addition of gangliosides to tissue culture cells causes a decrease in the tyrosine protein kinase activity of the epidermal growth factor (EGF) receptor and an inhibition of EGF-stimulated growth.	Gangliosides	16-28	epidermal growth factor receptor	Homo sapiens	118-156
2142159-3	1990	Based on these data, the hypothesis that the EGF receptor is physiologically regulated by gangliosides has been proposed by E.G. Bremer, J. Schlessinger, and S. Hakomori (J. Biol.	Gangliosides	90-102	epidermal growth factor receptor	Homo sapiens	45-57
2142159-9	1990	However, decreased levels of ganglioside expression were associated with 1) increased EGF receptor autophosphorylation on tyrosine residues, and 2) increased EGF-stimulated cellular proliferation.	Gangliosides	29-40	epidermal growth factor receptor	Homo sapiens	86-98
2142159-10	1990	The inverse correlation observed between the level of ganglioside expression and signal transduction by the EGF receptor is consistent with the hypothesis that the function of the EGF receptor is physiologically regulated by gangliosides.	Gangliosides	54-65	epidermal growth factor receptor	Homo sapiens	108-120
2142159-10	1990	The inverse correlation observed between the level of ganglioside expression and signal transduction by the EGF receptor is consistent with the hypothesis that the function of the EGF receptor is physiologically regulated by gangliosides.	Gangliosides	54-65	epidermal growth factor receptor	Homo sapiens	180-192
2142159-10	1990	The inverse correlation observed between the level of ganglioside expression and signal transduction by the EGF receptor is consistent with the hypothesis that the function of the EGF receptor is physiologically regulated by gangliosides.	Gangliosides	225-237	epidermal growth factor receptor	Homo sapiens	108-120
2142159-10	1990	The inverse correlation observed between the level of ganglioside expression and signal transduction by the EGF receptor is consistent with the hypothesis that the function of the EGF receptor is physiologically regulated by gangliosides.	Gangliosides	225-237	epidermal growth factor receptor	Homo sapiens	180-192
1695800-7	1990	The ganglioside and neutral glycolipid can inhibit the binding of LC-1 with the extract of SPC-A-1 cells.	Gangliosides	4-15	proline rich protein gene cluster	Homo sapiens	91-94
2110799-3	1990	IFN-gamma activation of endothelial cells resulted in a small change in GSL composition, but greatly increased surface expression of gangliosides and decreased surface expression of neutral GSLs.	Gangliosides	133-145	interferon gamma	Homo sapiens	0-9
2231782-1	1990	Adult mammalian retinas contain unusually high amounts of GD3, a ganglioside of the lactosylceramide series.	Gangliosides	65-76	GRDX	Homo sapiens	58-61
2231782-2	1990	In this respect, they differ from adult avian retina and other regions of the adult avian and mammalian brain, where GD3 is a minor ganglioside and gangliosides of the gangliotetraosylceramide series (GM1, GD1a, GD1b, GT1b) are the predominant ones.	Gangliosides	132-143	GRDX	Homo sapiens	117-120
2231782-8	1990	GD3 was a minor ganglioside among these axonally transported by ganglion cells in rats and guinea pigs, suggesting that it is either not synthesized by ganglion cells or, if so, it is restricted to the cell soma and/or dendritic tree.	Gangliosides	16-27	GRDX	Homo sapiens	0-3
2121721-1	1990	We previously reported the binding specificities of two anti-ganglioside GD2 murine monoclonal antibodies (MAbs), A1-425 and A1-267, both of which are of IgG3 isotype.	Gangliosides	61-72	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	154-158
1697781-3	1990	The binding of 125I-labeled CT to neuraminidase-treated human type B erythrocytes was effectively inhibited by ganglioside GM1, but not by porcine gastric mucin with both A and H determinants (hog A + H), blood group specific lectins, and other substances at the highest concentrations used.	Gangliosides	111-122	neuraminidase 1	Homo sapiens	34-47
2357534-2	1990	After 1 and 3 days postlesion (dpl), a decrease in ganglioside content was detected in area dentata (AD) and pyramidal cell regions CA1-CA3 (CA), both ipsilateral and contralateral to the lesion.	Gangliosides	51-62	carbonic anhydrase 1	Rattus norvegicus	132-139
2357844-4	1990	This purified IgM and its Fab fragments showed the same pattern of reactivity with gangliosides as that observed with whole serum.	Gangliosides	83-95	FA complementation group B	Homo sapiens	26-29
2144522-1	1990	The effect of the expression of the human adenovirus type 12 E1A gene on ganglioside composition of rat 3Y1 cells was investigated using cell lines established by introduction of recombinant vector DNA containing the E1A 13S- or 12S-mRNA cDNA placed downstream of the hormone-inducible promoter of mouse mammary tumor virus.	Gangliosides	73-84	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	61-64
2144522-4	1990	Ganglioside GM2 was also accumulated by induction of 13S-mRNA of adenovirus E1A gene.	Gangliosides	0-11	branched chain keto acid dehydrogenase E1 subunit alpha	Rattus norvegicus	76-79
2182778-0	1990	Ganglioside-modulated proteolysis by Ca2(+)-activated neutral proteinase (CANP): a role of glycoconjugates in CANP regulation.	Gangliosides	0-11	calpain 1	Homo sapiens	74-78
2182778-0	1990	Ganglioside-modulated proteolysis by Ca2(+)-activated neutral proteinase (CANP): a role of glycoconjugates in CANP regulation.	Gangliosides	0-11	calpain 1	Homo sapiens	110-114
2182778-1	1990	We examined ganglioside modulation of the activity of the millimolar Ca2(+)-sensitive form (mCANP) of calcium-activated neutral proteinase (CANP), which is enriched in myelin, from brain.	Gangliosides	12-23	calpain 1	Homo sapiens	102-138
2182778-1	1990	We examined ganglioside modulation of the activity of the millimolar Ca2(+)-sensitive form (mCANP) of calcium-activated neutral proteinase (CANP), which is enriched in myelin, from brain.	Gangliosides	12-23	calpain 1	Homo sapiens	93-97
2153431-2	1990	Human primary germ cell tumors were analyzed for the presence of the ganglioside GM2 using three specific monoclonal antibodies which can distinguish the molecular species of the sialic acid moiety: the antibody MK1-16 is specific for N-acetyl GM2, MK2-34 is specific for N-glycolyl GM2, and MK1-17 detects both N-acetyl and N-glycolyl GM2.	Gangliosides	69-80	epithelial cell adhesion molecule	Homo sapiens	212-218
1693693-0	1990	Myelin basic protein: interaction with calmodulin and gangliosides.	Gangliosides	54-66	myelin basic protein	Oryctolagus cuniculus	0-20
1693693-7	1990	MBP also formed tight complexes with gangliosides, but the presence of Ca2+ was not required.	Gangliosides	37-49	myelin basic protein	Oryctolagus cuniculus	0-3
1693693-8	1990	Binding of gangliosides to MBP-CaM complex released CaM from the complex.	Gangliosides	11-23	myelin basic protein	Oryctolagus cuniculus	27-30
1693693-8	1990	Binding of gangliosides to MBP-CaM complex released CaM from the complex.	Gangliosides	11-23	calmodulin	Oryctolagus cuniculus	31-34
1693693-8	1990	Binding of gangliosides to MBP-CaM complex released CaM from the complex.	Gangliosides	11-23	calmodulin	Oryctolagus cuniculus	52-55
1693693-9	1990	The ganglioside-binding sites in MBP were determined after trisecting the protein at two glutamic acid residues with Staphylococcus aureus V8 protease.	Gangliosides	4-15	myelin basic protein	Cavia porcellus	33-36
2222998-7	1990	Interleukin-2 (IL-2) production by ganglioside- and glycophorin-treated lymphocytes was unchanged.	Gangliosides	35-46	interleukin 2	Homo sapiens	0-13
2222998-7	1990	Interleukin-2 (IL-2) production by ganglioside- and glycophorin-treated lymphocytes was unchanged.	Gangliosides	35-46	interleukin 2	Homo sapiens	15-19
2222998-8	1990	After treatment with gangliosides for 24 h, lymphocytes proliferated normally in response to added IL-2.	Gangliosides	21-33	interleukin 2	Homo sapiens	99-103
2222998-10	1990	Addition of gangliosides to activated lymphocytes in the presence of IL-2 resulted in complete inhibition of proliferation.	Gangliosides	12-24	interleukin 2	Homo sapiens	69-73
2222998-11	1990	Immunosuppression by gangliosides and glycophorin thus appears to occur at the IL-2-dependent stage of proliferation and may be partially due to IL-2 binding to these molecules.	Gangliosides	21-33	interleukin 2	Homo sapiens	79-83
2222998-11	1990	Immunosuppression by gangliosides and glycophorin thus appears to occur at the IL-2-dependent stage of proliferation and may be partially due to IL-2 binding to these molecules.	Gangliosides	21-33	interleukin 2	Homo sapiens	145-149
2222998-12	1990	However, high levels of IL-2 failed to reverse inhibition and IL-2-dependent cell lines were much less sensitive to ganglioside inhibition than T-lymphocytes, suggesting that more than one mechanism of inhibition likely exists.	Gangliosides	116-127	interleukin 2	Homo sapiens	62-66
2373286-6	1990	This analysis, in which the new monoclonal antibodies VINIS-56 and VIN-2PB-22 were included, also revealed expression of gangliosides GD3 and GD2 in all differentiated cultures, albeit at much lower levels following HMBA exposure than following retinoic acid or BUdR-exposure.	Gangliosides	121-133	long intergenic non-protein coding RNA 1191	Homo sapiens	54-57
2373286-6	1990	This analysis, in which the new monoclonal antibodies VINIS-56 and VIN-2PB-22 were included, also revealed expression of gangliosides GD3 and GD2 in all differentiated cultures, albeit at much lower levels following HMBA exposure than following retinoic acid or BUdR-exposure.	Gangliosides	121-133	GRDX	Homo sapiens	134-137
2105840-1	1990	R24 is an IgG3 mouse monoclonal antibody which recognizes the ganglioside GD3.	Gangliosides	62-73	Immunoglobulin heavy constant gamma 3	Mus musculus	10-14
1689771-2	1990	The Gal(beta 1-3)GalNAc epitope is shared by the gangliosides GM1 and GD1b and by several glycoproteins in the nervous system, and binding was abolished by preabsorbing the patient"s serum with GM1.	Gangliosides	49-61	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	8-16
2303431-4	1990	Of the lipids tested, both native and activated properdin bind with high affinity only to sulfatide [Gal(3-SO4)beta 1-1 Cer], but not to comparable levels of cholesterol-3-SO4, or several neutral glycolipids, gangliosides, and phospholipids.	Gangliosides	209-221	complement factor properdin	Homo sapiens	48-57
1692197-9	1990	The melanoma associated ganglioside GD3 was mainly expressed on epitheloid type lesions while GD2 was predominantly expressed on mixed type lesions.	Gangliosides	24-35	GRDX	Homo sapiens	36-39
2130665-11	1990	Gangliosides are known to modulate the effect of nerve growth factor in some in vitro systems and very recent evidence implicates protein kinase activation as an important mechanism.	Gangliosides	0-12	nerve growth factor	Homo sapiens	49-68
2353923-0	1990	Ganglioside stimulation of nerve growth factor synthesis in cultured rat Schwann cells.	Gangliosides	0-11	nerve growth factor	Rattus norvegicus	27-46
2353923-3	1990	In the continuous presence of 10(-3) M gangliosides, the NGF concentration in the medium showed a four fold increase on the 4th day, and it then decreased by the 8th day.	Gangliosides	39-51	nerve growth factor	Rattus norvegicus	57-60
2353923-4	1990	The present results indicate that gangliosides promote the production/synthesis of NGF by Schwann cells.	Gangliosides	34-46	nerve growth factor	Rattus norvegicus	83-86
2364894-6	1990	Sequential treatment of PC12 cells resulted in a greater than 50% increase in the incorporation of fucose into neutral glycolipids and gangliosides compared to treatment with NGF alone.	Gangliosides	135-147	nerve growth factor	Rattus norvegicus	175-178
2364894-10	1990	In contrast to the effects of the sequential treatment, simultaneous NGF and forskolin treatment was accompanied by a decrease in the incorporation of fucose and galactose into neutral glycolipids and gangliosides.	Gangliosides	201-213	nerve growth factor	Rattus norvegicus	69-72
2182380-2	1990	The binding of 125I-labeled LTh-B to neuraminidase-treated human type B erythrocytes was most effectively inhibited by ganglioside GM1.	Gangliosides	119-130	neuraminidase 1	Homo sapiens	37-50
1968389-0	1990	Chemical residues of ganglioside molecules involved in interactions with lymphocyte surface targets leading to CD4 masking and inhibition of mitogenic proliferation.	Gangliosides	21-32	CD4 molecule	Homo sapiens	111-114
1968389-1	1990	Human lymphocyte CD4 becomes undetectable in the presence of exogenous gangliosides (CD4 masking), as originally described by Offner et al.	Gangliosides	71-83	CD4 molecule	Homo sapiens	17-20
1968389-1	1990	Human lymphocyte CD4 becomes undetectable in the presence of exogenous gangliosides (CD4 masking), as originally described by Offner et al.	Gangliosides	71-83	CD4 molecule	Homo sapiens	85-88
2136350-2	1990	The inhibitory activity of the ganglioside GM4 analog [Neu5Ac alpha(2-S-6)Gal beta(1-1)Ceramide (3)], in which the glucose of 1 was substituted by galactose, was lower than that of 1 (Ki = 1.0 x 10(-4) M).	Gangliosides	31-42	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	78-86
2332419-11	1990	Comparison of the ganglioside expression in liver and erythrocytes of the same backcross mice suggested that the gene controlling GM2(NeuGc) expression in the liver (Ggm-2) is also responsible for the expression of GM2(NeuGc) in erythrocytes.	Gangliosides	18-29	cytochrome b5 domain containing 2	Mus musculus	130-140
2332419-11	1990	Comparison of the ganglioside expression in liver and erythrocytes of the same backcross mice suggested that the gene controlling GM2(NeuGc) expression in the liver (Ggm-2) is also responsible for the expression of GM2(NeuGc) in erythrocytes.	Gangliosides	18-29	beta-1,4-N-acetyl-galactosaminyl transferase 1	Mus musculus	166-171
2332419-11	1990	Comparison of the ganglioside expression in liver and erythrocytes of the same backcross mice suggested that the gene controlling GM2(NeuGc) expression in the liver (Ggm-2) is also responsible for the expression of GM2(NeuGc) in erythrocytes.	Gangliosides	18-29	cytochrome b5 domain containing 2	Mus musculus	215-225
2351703-1	1990	Some neuron-derived cells, such as neuroblastoma cells, adhere and extend neurites on fibronectin (FN) substrata by processes that can be independent of binding to the Arg-Gly-Asp-Ser sequence (RGDS in FN) and independent of proteoglycan/ganglioside-binding activities of FN.	Gangliosides	238-249	fibronectin 1	Homo sapiens	99-101
2110523-5	1990	GM3 and GD3 were the most abundant ganglioside species in each strain and comprised approximately 75% of the total distribution.	Gangliosides	35-46	granulocyte macrophage antigen 3	Mus musculus	0-3
2328944-1	1990	A simple and rapid procedure using anion exchange chromatography was established for determinations of the activity of ganglioside GD3 synthase (CMP-NeuAc: GM3, alpha 2----8 sialyltransferase) which catalyzes the conversion of ganglioside GM3 to GD3.	Gangliosides	119-130	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Rattus norvegicus	131-143
2182380-6	1990	These results suggest that the predominant binding substance for LTh-B on neuraminidase-treated human type B erythrocytes is ganglioside GM1, but indicate that the interaction of LTh-B with ganglioside GM1 is different in hemagglutination.	Gangliosides	125-136	neuraminidase 1	Homo sapiens	74-87
2153774-0	1990	Ganglioside-enhanced neurite growth: evidence for a selective induction of high-molecular-weight MAP-2.	Gangliosides	0-11	microtubule associated protein 2	Bos taurus	97-102
2153774-3	1990	We report here that one effect of gangliosides is the selective and dramatic induction of MAP-2 expression.	Gangliosides	34-46	microtubule associated protein 2	Bos taurus	90-95
2150416-0	1990	Ganglioside inhibition of (125I)-plasmin binding to colorectal carcinoma cells.	Gangliosides	0-11	plasminogen	Homo sapiens	33-40
2150416-1	1990	The pre-incubation of human colorectal carcinoma cells SW 1116 with 25 to 100 uM purified gangliosides resulted in 35-60% inhibition of specific (125I)-plasmin binding to the cell surface.	Gangliosides	90-102	plasminogen	Homo sapiens	152-159
2260105-1	1990	Tetanus toxin blocks Ca2(+)-evoked catecholamine release from permeabilized bovine adrenal chromaffin cells preloaded with gangliosides.	Gangliosides	123-135	carbonic anhydrase 2	Bos taurus	21-24
2313655-3	1990	The major acidic glycolipids (gangliosides) were identified similarly as GM3 and GD3, with lesser amounts of GM1, GD1a, and GT1b.	Gangliosides	30-42	GRDX	Homo sapiens	81-84
1690317-10	1990	Immunostaining of glycosphingolipids isolated from myeloid cells demonstrated that the SSEA-1 epitope is carried by several neutral glycosphingolipids and that the VIM-2 epitope is carried by three or more gangliosides.	Gangliosides	206-218	vimentin 2, pseudogene	Homo sapiens	164-169
19184418-9	2009	A similar effect was observed with the GLTs involved in the biosyntheses of Gg-series gangliosides, such as SAT-4 (CMP-NeuAc: GgOse4Cer alpha2, 3sialyltransferase, and SAT-2 (CMP-NeuAc: GM3 alpha2, 8sialyltransferase).	Gangliosides	86-98	spermidine/spermine N1-acetyltransferase family member 2	Homo sapiens	168-173
21157375-4	2011	In the cerebellar molecular layer, alpha-mannosidosis mice display clusters of activated Bergman glia, infiltration of phagocytic macrophages, and accumulation of free cholesterol and gangliosides (GM1), notably in regions lacking Purkinje cells.	Gangliosides	184-196	coenzyme Q10A	Mus musculus	198-201
33803928-6	2021	Proteome-based mechanistic analysis revealed that inhibition of ganglioside synthesis downregulated the expression of AURKA, AURKB, TTK, and NDC80 involved in the regulation of kinetochore metaphase signaling, which is essential for chromosome segregation and mitotic progression and probably under the control of activation of TP53-dependent cell cycle arrest.	Gangliosides	64-75	aurora kinase A	Homo sapiens	118-123
33803928-6	2021	Proteome-based mechanistic analysis revealed that inhibition of ganglioside synthesis downregulated the expression of AURKA, AURKB, TTK, and NDC80 involved in the regulation of kinetochore metaphase signaling, which is essential for chromosome segregation and mitotic progression and probably under the control of activation of TP53-dependent cell cycle arrest.	Gangliosides	64-75	aurora kinase B	Homo sapiens	125-130
33803928-6	2021	Proteome-based mechanistic analysis revealed that inhibition of ganglioside synthesis downregulated the expression of AURKA, AURKB, TTK, and NDC80 involved in the regulation of kinetochore metaphase signaling, which is essential for chromosome segregation and mitotic progression and probably under the control of activation of TP53-dependent cell cycle arrest.	Gangliosides	64-75	TTK protein kinase	Homo sapiens	132-135
33803928-6	2021	Proteome-based mechanistic analysis revealed that inhibition of ganglioside synthesis downregulated the expression of AURKA, AURKB, TTK, and NDC80 involved in the regulation of kinetochore metaphase signaling, which is essential for chromosome segregation and mitotic progression and probably under the control of activation of TP53-dependent cell cycle arrest.	Gangliosides	64-75	NDC80 kinetochore complex component	Homo sapiens	141-146
33803928-6	2021	Proteome-based mechanistic analysis revealed that inhibition of ganglioside synthesis downregulated the expression of AURKA, AURKB, TTK, and NDC80 involved in the regulation of kinetochore metaphase signaling, which is essential for chromosome segregation and mitotic progression and probably under the control of activation of TP53-dependent cell cycle arrest.	Gangliosides	64-75	tumor protein p53	Homo sapiens	328-332
33034545-7	2021	Moreover, this interaction depends on the "integrity" of key molecules, such as ganglioside GD3 and MFN2.	Gangliosides	80-91	GRDX	Homo sapiens	92-95
34754101-2	2022	Here, we reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides.	Gangliosides	187-199	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	62-67
2040532-0	1991	Antibody response to immunization with ganglioside GD3 and GD3 congeners (lactones, amide and gangliosidol) in patients with malignant melanoma.	Gangliosides	39-50	GRDX	Homo sapiens	51-54
2040532-1	1991	GD3 is the ganglioside most abundantly expressed on the cell surface of human melanoma, and treatment with a murine MAb recognizing GD3 has induced major responses in a small proportion of patients with melanoma.	Gangliosides	11-22	GRDX	Homo sapiens	0-3
2040532-1	1991	GD3 is the ganglioside most abundantly expressed on the cell surface of human melanoma, and treatment with a murine MAb recognizing GD3 has induced major responses in a small proportion of patients with melanoma.	Gangliosides	11-22	GRDX	Homo sapiens	132-135
34716425-2	2022	MFGM contains lipids and glycoproteins as well as gangliosides, which may be involved in myelination processes.	Gangliosides	50-62	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	0-4
34754101-2	2022	Here, we reveal that the receptor-binding domain (RBD) of the spike (S) protein on SARS-CoV-2 recognizes oligosaccharides containing sialic acid (Sia), with preference for monosialylated gangliosides.	Gangliosides	187-199	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	69-70
34948386-5	2021	Cell surface staining and confocal microscopy identified GM1 as the main complex ganglioside co-localizing with Neuroplastin in cultured hippocampal neurons.	Gangliosides	81-92	coenzyme Q10A	Mus musculus	57-60
34948386-5	2021	Cell surface staining and confocal microscopy identified GM1 as the main complex ganglioside co-localizing with Neuroplastin in cultured hippocampal neurons.	Gangliosides	81-92	neuroplastin	Mus musculus	112-124
34944404-1	2021	A deficiency in GM3-derived gangliosides, resulting from a lack of lactosylceramide-alpha-2,3-sialyltransferase (ST3GAL5), leads to severe neuropathology, including epilepsy and metabolic abnormalities.	Gangliosides	28-40	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	113-120
34882796-6	2022	Integrated multivariate imaging data analysis revealed multiple, Abeta plaque enriched lipid patterns for gangliosides (GM), phosphoinositols (PI), phosphoethanolamines (PE) and phosphatidic acids (PA).	Gangliosides	106-118	amyloid beta (A4) precursor protein	Mus musculus	65-70
34788022-0	2021	Manipulation of Ion Types via Gas-Phase Ion/Ion Chemistry for the Structural Characterization of the Glycan Moiety on Gangliosides.	Gangliosides	118-130	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	30-33
34788022-4	2021	The gas-phase derivatization strategy provides a rapid way to manipulate the ion-types of the precursor ions, and, in conjunction with collision induced dissociation (CID), allows for the elucidation of the structures of the glycan moieties from gangliosides.	Gangliosides	246-258	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	4-7
34788022-14	2021	The results demonstrate the applicability and strength of using shotgun MS coupled with gas-phase ion/ion chemistry to characterize the glycan moiety structures on different subclasses of gangliosides.	Gangliosides	188-200	galactosamine (N-acetyl)-6-sulfatase	Homo sapiens	88-91
34944404-3	2021	ST3Gal5 knock-out (St3gal5-/-) mice lack a-, b-, and c-series gangliosides, but exhibit no overt neuropathology, possibly owing to the production of compensatory 0-series glycosphingolipids.	Gangliosides	62-74	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-7
34944404-3	2021	ST3Gal5 knock-out (St3gal5-/-) mice lack a-, b-, and c-series gangliosides, but exhibit no overt neuropathology, possibly owing to the production of compensatory 0-series glycosphingolipids.	Gangliosides	62-74	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	19-26
34492428-0	2021	Chemoenzymatic synthesis and biological evaluation of ganglioside GM3 and lyso-GM3 as potential agents for cancer therapy.	Gangliosides	54-65	granulocyte macrophage antigen 3	Mus musculus	66-69
34943806-7	2021	This resulted in decreased synthesis of the ganglioside GM3, the product of ST3Gal5.	Gangliosides	44-55	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	76-83
34830075-4	2021	When hNME1 binds with pST8SIA1, it induces degradation of pST8SIA1 in mp AD-MSCs, thereby inhibiting the expression of ganglioside GD3 followed by decreased neuronal differentiation of mp AD-MSCs.	Gangliosides	119-130	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	5-10
34830075-6	2021	Consequently, NB-hNME1 effectively blocked the binding of hNME1 to pST8SIA1, thereby recovering the expression of ganglioside GD3 and neuronal differentiation of mp AD-MSCs.	Gangliosides	114-125	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	17-22
34830075-6	2021	Consequently, NB-hNME1 effectively blocked the binding of hNME1 to pST8SIA1, thereby recovering the expression of ganglioside GD3 and neuronal differentiation of mp AD-MSCs.	Gangliosides	114-125	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	58-63
34492428-1	2021	A highly efficient chemoenzymatic method for synthesizing ganglioside GM3 and lyso-GM3 was reported here.	Gangliosides	58-69	granulocyte macrophage antigen 3	Mus musculus	70-73
34492428-3	2021	Ganglioside GM3 was synthesized through 10 steps with a total yield of 22%.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
34492428-6	2021	All ganglioside GM3 and lyso-GM3 can effectively inhibit the migration of melanoma B16-F10 cells.	Gangliosides	4-15	granulocyte macrophage antigen 3	Mus musculus	16-19
34686927-4	2021	In addition, we showed that there is an increased level of GD1a ganglioside and a markedly decreased level of GM1 ganglioside in the brain of Neu4-/- mice.	Gangliosides	64-75	sialidase 4	Mus musculus	142-146
34530055-3	2021	CD33 receptors recognize the alpha2,3 and alpha2,6-linked sialic groups in tissue glycocalyx, especially sialylated gangliosides in human brain.	Gangliosides	116-128	CD33 molecule	Homo sapiens	0-4
34530055-7	2021	Moreover, hypoxia/ischemia increases the deposition of sialylated gangliosides, e.g., GM1, GM2, GM3, and GD1, which are ligands for inhibitory CD33/Siglec-3 receptors.	Gangliosides	66-78	CD33 molecule	Homo sapiens	143-147
34530055-10	2021	Sialylated gangliosides in plaques might stimulate the CD33/Siglec-3 receptors of microglia and thus impede TREM2-driven phagocytosis.	Gangliosides	11-23	CD33 molecule	Homo sapiens	55-59
34530055-10	2021	Sialylated gangliosides in plaques might stimulate the CD33/Siglec-3 receptors of microglia and thus impede TREM2-driven phagocytosis.	Gangliosides	11-23	CD33 molecule	Homo sapiens	60-68
34530055-10	2021	Sialylated gangliosides in plaques might stimulate the CD33/Siglec-3 receptors of microglia and thus impede TREM2-driven phagocytosis.	Gangliosides	11-23	triggering receptor expressed on myeloid cells 2	Homo sapiens	108-113
34530055-11	2021	We propose that hypoxia/ischemia, e.g., via the accumulation of sialylated gangliosides, prevents the phagocytosis of beta-amyloid deposits by inhibiting CD33/TREM2 signaling.	Gangliosides	75-87	CD33 molecule	Homo sapiens	154-158
34530055-11	2021	We propose that hypoxia/ischemia, e.g., via the accumulation of sialylated gangliosides, prevents the phagocytosis of beta-amyloid deposits by inhibiting CD33/TREM2 signaling.	Gangliosides	75-87	triggering receptor expressed on myeloid cells 2	Homo sapiens	159-164
34768981-2	2021	Our study is based on the design of a small peptide inhibitor (AmyP53) that combines the ganglioside recognition properties of the beta-amyloid peptide (Abeta, Alzheimer) and alpha-synuclein (alpha-syn, Parkinson).	Gangliosides	89-100	amyloid beta precursor protein	Homo sapiens	131-151
34768981-2	2021	Our study is based on the design of a small peptide inhibitor (AmyP53) that combines the ganglioside recognition properties of the beta-amyloid peptide (Abeta, Alzheimer) and alpha-synuclein (alpha-syn, Parkinson).	Gangliosides	89-100	amyloid beta precursor protein	Homo sapiens	153-158
34768981-2	2021	Our study is based on the design of a small peptide inhibitor (AmyP53) that combines the ganglioside recognition properties of the beta-amyloid peptide (Abeta, Alzheimer) and alpha-synuclein (alpha-syn, Parkinson).	Gangliosides	89-100	synuclein alpha	Homo sapiens	175-190
34768981-2	2021	Our study is based on the design of a small peptide inhibitor (AmyP53) that combines the ganglioside recognition properties of the beta-amyloid peptide (Abeta, Alzheimer) and alpha-synuclein (alpha-syn, Parkinson).	Gangliosides	89-100	synuclein alpha	Homo sapiens	192-201
34744762-5	2021	L-PGDS binds retinoic acids and retinal with high affinities (Kd < 100 nM) and diverse small lipophilic substances, such as thyroids, gangliosides, bilirubin and biliverdin, heme, NAD(P)H, and PGD2, acting as an extracellular carrier of these substances.	Gangliosides	134-146	prostaglandin D2 synthase	Homo sapiens	0-6
34328693-8	2021	Carnosinase-1 levels were positively associated with total phosphatidylethanolamines, but negatively with lysoalkylphosphatidylcholines, trihexosylceramides, and gangliosides.	Gangliosides	162-174	carnosine dipeptidase 1	Homo sapiens	0-13
34650728-0	2021	Effect of gangliosides combined with mouse NGF on the expression of serum HIF-1alpha, NSE, and sICAM-1 levels in neonates with HIE.	Gangliosides	10-22	hypoxia inducible factor 1, alpha subunit	Mus musculus	74-84
34650728-1	2021	OBJECTIVE: This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1alpha (HIF-1alpha), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).	Gangliosides	62-74	hypoxia inducible factor 1, alpha subunit	Mus musculus	148-179
34650728-1	2021	OBJECTIVE: This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1alpha (HIF-1alpha), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).	Gangliosides	62-74	hypoxia inducible factor 1, alpha subunit	Mus musculus	181-191
34650728-0	2021	Effect of gangliosides combined with mouse NGF on the expression of serum HIF-1alpha, NSE, and sICAM-1 levels in neonates with HIE.	Gangliosides	10-22	enolase 2, gamma neuronal	Mus musculus	86-89
34650728-1	2021	OBJECTIVE: This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1alpha (HIF-1alpha), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).	Gangliosides	62-74	enolase 2, gamma neuronal	Mus musculus	194-217
34650728-1	2021	OBJECTIVE: This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1alpha (HIF-1alpha), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).	Gangliosides	62-74	enolase 2, gamma neuronal	Mus musculus	219-222
34650728-1	2021	OBJECTIVE: This study was intended to evaluate the effects of gangliosides combined with mouse nerve growth factor (NGF) on the expression of serum hypoxia-inducible factor-1alpha (HIF-1alpha), neuron-specific enolase (NSE), and soluble intercellular adhesion molecule-1 (sICAM-1) levels in neonates with ischemic-hypoxic encephalopathy (HIE).	Gangliosides	62-74	intercellular adhesion molecule 1	Mus musculus	237-270
34089757-6	2021	However, other patterns increase the electropositive surface of the spike, with determinant effects on the kinetics of virus adhesion to lipid raft gangliosides.	Gangliosides	148-160	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	68-73
34587700-14	2021	CONCLUSIONS: MFGM supplementation in early life supports adequate growth, increased serum gangliosides concentration and improves some measures of cognitive development in Chinese infants.	Gangliosides	90-102	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	13-17
34445169-0	2021	CD82 and Gangliosides Tune CD81 Membrane Behavior.	Gangliosides	9-21	CD81 molecule	Homo sapiens	27-31
34145699-1	2021	High expressions of ganglioside GD3 and GD2 are observed in human gliomas.	Gangliosides	20-31	GRDX	Homo sapiens	32-35
34148503-2	2021	Gangliosides play a role in modulating effector cells of the immune system, such as CD4+ and CD8+ T-cells and NK cells, and HLTs provide a novel means for stimulating ganglioside-mediated responses in immunocompetent cells.	Gangliosides	0-12	CD4 molecule	Homo sapiens	84-87
34148503-2	2021	Gangliosides play a role in modulating effector cells of the immune system, such as CD4+ and CD8+ T-cells and NK cells, and HLTs provide a novel means for stimulating ganglioside-mediated responses in immunocompetent cells.	Gangliosides	0-12	CD8a molecule	Homo sapiens	93-96
34337561-6	2021	HSN1 iPSC models have, therefore, revealed that SPTLC1 mutation alters lipid metabolism, impairs the formation of complex gangliosides, and reduces axon and myelin stability.	Gangliosides	122-134	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	0-4
34133773-8	2021	Interestingly, the impaired phagocytic capacity of GD3S-KO microglia could be partially restored by pre-treatment with exogenous ganglioside GD3.	Gangliosides	129-140	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	51-55
34328594-6	2022	The first step of this cascade is the binding of alpha-synuclein to lipid raft gangliosides, suggesting that PD should be considered as both a proteinopathy and a ganglioside membrane disorder lipidopathy.	Gangliosides	79-91	synuclein alpha	Homo sapiens	49-64
34328594-7	2022	Accordingly, blocking alpha-synuclein-ganglioside interactions should annihilate the whole neurotoxic cascade and stop disease progression.	Gangliosides	38-49	synuclein alpha	Homo sapiens	22-37
34328594-8	2022	A pipeline of anti-oligomer molecules is under development, among which an in-silico designed synthetic peptide AmyP53 which is the first drug targeting gangliosides and thus able to prevent the formation of alpha-synuclein oligomers and all downstream neurotoxicity.	Gangliosides	153-165	synuclein alpha	Homo sapiens	208-223
34589798-4	2021	In humans, the loss of lactosylceramide-alpha-2,3-sialyltransferase (ST3Gal5) leads to a severe neuropathology, but in ST3Gal5 knock-out (St3gal5-/-) mice the absence of GM3 and associated a-, b- and c-series gangliosides is partially compensated by 0-series gangliosides and there is no overt behavioural phenotype.	Gangliosides	209-221	granulocyte macrophage antigen 3	Mus musculus	170-201
34589798-10	2021	Together, the St3gal5-/- mice display ASD-like behavioural features, altered response to systemic inflammation, signs of hypomyelination and neuroinflammation, which suggests that deficiency in a- and b-series gangliosides could contribute to the development of an ASD-like pathology in humans.	Gangliosides	210-222	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	14-21
34081777-2	2021	The enzyme GD3 synthase converts GM3 (an a- series ganglioside) to GD3, a b- series ganglioside highly expressed in the developing and adult retina.	Gangliosides	51-62	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	11-23
34081777-2	2021	The enzyme GD3 synthase converts GM3 (an a- series ganglioside) to GD3, a b- series ganglioside highly expressed in the developing and adult retina.	Gangliosides	84-95	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	11-23
34133773-2	2021	Here, we show that the b-series ganglioside GD3 and its biosynthetic enzyme, GD3-synthase (GD3S), were up-regulated predominantly in the microglia of mouse hippocampus from 2 to 7 days following global cerebral ischemia (GCI).	Gangliosides	32-43	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	77-89
34133773-2	2021	Here, we show that the b-series ganglioside GD3 and its biosynthetic enzyme, GD3-synthase (GD3S), were up-regulated predominantly in the microglia of mouse hippocampus from 2 to 7 days following global cerebral ischemia (GCI).	Gangliosides	32-43	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Mus musculus	91-95
34354392-0	2021	Effect of ganglioside combined with Chip Jiaji electro-acupuncture on Nogo-NgR signal pathway in SCI rats.	Gangliosides	10-21	reticulon 4	Rattus norvegicus	70-74
34354392-0	2021	Effect of ganglioside combined with Chip Jiaji electro-acupuncture on Nogo-NgR signal pathway in SCI rats.	Gangliosides	10-21	reticulon 4 receptor	Rattus norvegicus	75-78
34354392-2	2021	This study explores the effect of ganglioside combined with electroacupuncture on Nogo/NgR signal pathway in spinal cord tissue of spinal cord injury (SCI) rats.	Gangliosides	34-45	reticulon 4	Rattus norvegicus	82-86
34354392-2	2021	This study explores the effect of ganglioside combined with electroacupuncture on Nogo/NgR signal pathway in spinal cord tissue of spinal cord injury (SCI) rats.	Gangliosides	34-45	reticulon 4 receptor	Rattus norvegicus	87-90
34354392-6	2021	The expression levels of IL-1beta, IL-6 and TNF-alpha in Jiaji EA group, ganglioside group and combination group were significantly lower than those in model group.	Gangliosides	73-84	interleukin 1 alpha	Rattus norvegicus	25-33
34354392-6	2021	The expression levels of IL-1beta, IL-6 and TNF-alpha in Jiaji EA group, ganglioside group and combination group were significantly lower than those in model group.	Gangliosides	73-84	interleukin 6	Rattus norvegicus	35-39
34354392-6	2021	The expression levels of IL-1beta, IL-6 and TNF-alpha in Jiaji EA group, ganglioside group and combination group were significantly lower than those in model group.	Gangliosides	73-84	tumor necrosis factor	Rattus norvegicus	44-53
34354392-7	2021	Both of mRNA and protein expression levels of Nogo-A, NgR and LINGO-1 in the model group were significantly higher than those in the Jiaji EA group, ganglioside group and combination group.	Gangliosides	149-160	reticulon 4	Rattus norvegicus	46-52
34354392-7	2021	Both of mRNA and protein expression levels of Nogo-A, NgR and LINGO-1 in the model group were significantly higher than those in the Jiaji EA group, ganglioside group and combination group.	Gangliosides	149-160	leucine rich repeat and Ig domain containing 1	Rattus norvegicus	62-69
34328594-0	2022	Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic alpha-synuclein oligomers in Parkinson"s disease.	Gangliosides	31-43	synuclein alpha	Homo sapiens	90-105
34337561-6	2021	HSN1 iPSC models have, therefore, revealed that SPTLC1 mutation alters lipid metabolism, impairs the formation of complex gangliosides, and reduces axon and myelin stability.	Gangliosides	122-134	serine palmitoyltransferase long chain base subunit 1	Homo sapiens	48-54
34291075-0	2021	Ganglioside Alters Phospholipase Trafficking, Inhibits NF-kappaB Assembly, and Protects Tight Junction Integrity.	Gangliosides	0-11	nuclear factor kappa B subunit 1	Homo sapiens	55-64
34291075-9	2021	Ganglioside decreased the basolateral secretion of sPLA2 (P <= 0.05), lowered HBD-2 and IL-23 levels (P <= 0.05), and inhibited NF-kappaB activation (P <= 0.05).	Gangliosides	0-11	phospholipase A2 group X	Homo sapiens	51-56
34291075-9	2021	Ganglioside decreased the basolateral secretion of sPLA2 (P <= 0.05), lowered HBD-2 and IL-23 levels (P <= 0.05), and inhibited NF-kappaB activation (P <= 0.05).	Gangliosides	0-11	defensin beta 4A	Homo sapiens	78-83
34291075-9	2021	Ganglioside decreased the basolateral secretion of sPLA2 (P <= 0.05), lowered HBD-2 and IL-23 levels (P <= 0.05), and inhibited NF-kappaB activation (P <= 0.05).	Gangliosides	0-11	interleukin 23 subunit alpha	Homo sapiens	88-93
34291075-9	2021	Ganglioside decreased the basolateral secretion of sPLA2 (P <= 0.05), lowered HBD-2 and IL-23 levels (P <= 0.05), and inhibited NF-kappaB activation (P <= 0.05).	Gangliosides	0-11	nuclear factor kappa B subunit 1	Homo sapiens	128-137
34291075-10	2021	Conclusions: In summary, the present study indicates that ganglioside GD3 improves intestinal integrity by altering sPLA2 trafficking, and the production of pro-inflammatory mediators is mitigated by decreasing assembly of the NF-kappaB complex.	Gangliosides	58-69	phospholipase A2 group X	Homo sapiens	116-121
34291075-10	2021	Conclusions: In summary, the present study indicates that ganglioside GD3 improves intestinal integrity by altering sPLA2 trafficking, and the production of pro-inflammatory mediators is mitigated by decreasing assembly of the NF-kappaB complex.	Gangliosides	58-69	nuclear factor kappa B subunit 1	Homo sapiens	227-236
34242725-3	2021	Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate.	Gangliosides	242-254	epidermal growth factor receptor	Homo sapiens	0-32
34242725-3	2021	Epidermal growth factor receptor (EGFR) is one of the most extensively studied receptors exhibiting various lipid interactions, including interactions with phosphatidylcholine, phosphatidylserine, phosphatidylinositol phosphate, cholesterol, gangliosides, and palmitate.	Gangliosides	242-254	epidermal growth factor receptor	Homo sapiens	34-38
34110944-8	2021	EXPERT OPINION: We propose a mechanism through which activation of sigma-1R and autophagy could alter amyloid precursor protein processing to inhibit amyloid-beta production by reconstituting cholesterol and gangliosides in the lipid raft to offer neuroprotection against AD.	Gangliosides	208-220	sigma non-opioid intracellular receptor 1	Homo sapiens	67-75
34125497-1	2021	Two decades ago, we achieved molecular cloning of ganglioside GM3 synthase (GM3S; ST3GAL5), the enzyme responsible for initiating biosynthesis of complex gangliosides.	Gangliosides	154-166	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	50-74
34125497-1	2021	Two decades ago, we achieved molecular cloning of ganglioside GM3 synthase (GM3S; ST3GAL5), the enzyme responsible for initiating biosynthesis of complex gangliosides.	Gangliosides	154-166	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Homo sapiens	82-89
34208013-0	2021	Role of Sialyl-O-Acetyltransferase CASD1 on GD2 Ganglioside O-Acetylation in Breast Cancer Cells.	Gangliosides	48-59	CAS1 domain containing 1	Homo sapiens	35-40
34110944-8	2021	EXPERT OPINION: We propose a mechanism through which activation of sigma-1R and autophagy could alter amyloid precursor protein processing to inhibit amyloid-beta production by reconstituting cholesterol and gangliosides in the lipid raft to offer neuroprotection against AD.	Gangliosides	208-220	amyloid beta precursor protein	Homo sapiens	102-127
34989000-5	2022	Lines of evidence suggest that B cell response to non-protein self-antigens such as nucleic acids and gangliosides, sialic acid-containing glycolipids, are suppressed by inhibitory B cell co-receptors CD72 and Siglec-G, respectively.	Gangliosides	102-114	CD72 molecule	Homo sapiens	201-205
34453296-3	2021	This work from studies on potentially neuro-reparative gangliosides, their interactions with NGF, the role of exogenous NGF in the recovery of degenerating cholinergic neurons of the basal forebrain to the evidence that endogenous NGF maintains the "day-to-day" cortical synaptic phenotype and the discovery of a novel CNS "NGF metabolic pathway."	Gangliosides	55-67	nerve growth factor	Homo sapiens	93-96
34597626-8	2021	Depletion of ABCA12, implicated in GlcCer transport, preferentially decreased neutral GSL levels, while ABCB1 KD preferentially reduced gangliosides, but increased neutral GSL Gb3.	Gangliosides	136-148	ATP binding cassette subfamily B member 1	Homo sapiens	104-109
35580354-10	2022	Moreover, the Abeta-membrane interaction was found to be governed by the repulsive electrostatic interaction between Abeta and the ganglioside GM1 lipid.	Gangliosides	131-142	amyloid beta precursor protein	Homo sapiens	14-19
35580354-10	2022	Moreover, the Abeta-membrane interaction was found to be governed by the repulsive electrostatic interaction between Abeta and the ganglioside GM1 lipid.	Gangliosides	131-142	amyloid beta precursor protein	Homo sapiens	117-122
35506864-1	2022	Niemann-Pick disease type C (NPC) is characterized by the accumulation of glycolipids such as free cholesterol, sphingomyelin, and gangliosides in late endosomes/lysosomes (endolysosomes) due to abnormalities in the membrane proteins NPC1 or NPC2.	Gangliosides	131-143	NPC intracellular cholesterol transporter 1	Mus musculus	234-238
35506864-1	2022	Niemann-Pick disease type C (NPC) is characterized by the accumulation of glycolipids such as free cholesterol, sphingomyelin, and gangliosides in late endosomes/lysosomes (endolysosomes) due to abnormalities in the membrane proteins NPC1 or NPC2.	Gangliosides	131-143	NPC intracellular cholesterol transporter 2	Mus musculus	242-246
34395855-17	2021	Both raft morphology and ganglioside composition were altered by deficiency of ACSVL3.	Gangliosides	25-36	solute carrier family 27 (fatty acid transporter), member 3	Mus musculus	79-85
34467279-0	2021	Ganglioside GM3 Analogues Containing Monofluoromethylene-Linked Sialoside: Synthesis, Stereochemical Effects, Conformational Behavior, and Biological Activities.	Gangliosides	0-11	granulocyte macrophage antigen 3	Mus musculus	12-15
34467279-3	2021	Here we report sialidase-resistant analogues of ganglioside GM3 containing a monofluoromethylene linkage instead of the native O-sialoside linkage.	Gangliosides	48-59	granulocyte macrophage antigen 3	Mus musculus	60-63
35576641-7	2022	In our two cases, some paranodes seem to be associated with macrophages and we hypothesized that these lesions are in favor of a complement-mediated dysfunction/disruption of the nodal region due to disialosyl antibodies against gangliosides which are mainly located at the level of the axolemma of the paranode.	Gangliosides	229-241	nodal growth differentiation factor	Homo sapiens	179-184
35620166-11	2022	In male Abca7 knockout mice, the neuroprotective ganglioside GD1a levels were elevated and inversely correlated with amyloid-beta42 levels.	Gangliosides	49-60	ATP-binding cassette, sub-family A (ABC1), member 7	Mus musculus	8-13
35558506-3	2022	In this study, we found that overexpression of B3GALT4, the glycosyltransferase responsible for ganglioside GM1 synthesis, can induce the epithelial-mesenchymal transition (EMT) process in MCF-10A cells.	Gangliosides	96-107	beta-1,3-galactosyltransferase 4	Homo sapiens	47-54
34982351-2	2022	St8sia5 is an alpha2,8-sialyltransferase involved in ganglioside synthesis, and has three isoforms.	Gangliosides	53-64	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5	Homo sapiens	0-7
35156158-5	2022	Primary CD4+ T cells and CD8+ T cells preferentially express differing ganglioside series: a-series and o-series, respectively.	Gangliosides	71-82	CD4 antigen	Mus musculus	8-11
35156158-8	2022	Ganglioside GM3 synthase deficiency, which results in lack of a-series gangliosides, ameliorated CD4+ T cell-mediated airway hypersensitivity in a mouse model of allergic asthma.	Gangliosides	71-83	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	Mus musculus	0-24
35156158-8	2022	Ganglioside GM3 synthase deficiency, which results in lack of a-series gangliosides, ameliorated CD4+ T cell-mediated airway hypersensitivity in a mouse model of allergic asthma.	Gangliosides	71-83	CD4 antigen	Mus musculus	97-100
35168327-7	2022	Our data reveal TFs GATA2, GATA1, and RUNX1 as candidate inducers of the expression of gangliosides and sialylation via regulation of the GTs ST3GAL2 and ST8SIA1.	Gangliosides	87-99	GATA binding protein 2	Homo sapiens	20-25
35168327-7	2022	Our data reveal TFs GATA2, GATA1, and RUNX1 as candidate inducers of the expression of gangliosides and sialylation via regulation of the GTs ST3GAL2 and ST8SIA1.	Gangliosides	87-99	GATA binding protein 1	Homo sapiens	27-32
35168327-7	2022	Our data reveal TFs GATA2, GATA1, and RUNX1 as candidate inducers of the expression of gangliosides and sialylation via regulation of the GTs ST3GAL2 and ST8SIA1.	Gangliosides	87-99	RUNX family transcription factor 1	Homo sapiens	38-43
35168327-7	2022	Our data reveal TFs GATA2, GATA1, and RUNX1 as candidate inducers of the expression of gangliosides and sialylation via regulation of the GTs ST3GAL2 and ST8SIA1.	Gangliosides	87-99	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	Homo sapiens	142-149
35168327-7	2022	Our data reveal TFs GATA2, GATA1, and RUNX1 as candidate inducers of the expression of gangliosides and sialylation via regulation of the GTs ST3GAL2 and ST8SIA1.	Gangliosides	87-99	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1	Homo sapiens	154-161
35083577-5	2022	Spike structural predictions indicated a 1.3-time higher transmissibility index than for the globally spread B.1.1.7 variant but also an affinity loss for gangliosides that might have slowed dissemination.	Gangliosides	155-167	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	0-5
35066644-2	2022	Studies on SPG11 patients" fibroblasts, post-mortem brains, and mouse models revealed endolysosomal system dysfunction and lipid accumulation, especially gangliosides.	Gangliosides	154-166	SPG11 vesicle trafficking associated, spatacsin	Homo sapiens	11-16
35105352-0	2022	Glucosylceramide synthase inhibition reduces ganglioside GM3 accumulation, alleviates amyloid neuropathology, and stabilizes remote contextual memory in a mouse model of Alzheimer"s disease.	Gangliosides	45-56	UDP-glucose ceramide glucosyltransferase	Mus musculus	0-25
35204675-4	2022	We show similar findings for ganglioside GD1a, which is the metabolic precursor to GM1.	Gangliosides	29-40	coenzyme Q10A	Mus musculus	83-86
35228371-4	2022	GM3, the simplest ganglioside comprising alpha2,3-sialyllactose, is expressed in insulin-sensitive peripheral tissues such as liver and adipose tissue, and furthermore secreted abundantly into serum.	Gangliosides	18-29	insulin	Homo sapiens	81-88
35060438-4	2022	RESULTS: The Abeta-infused animals showed a significant decrease in ganglioside concentration and relative reduction of GD1b and GQ1b species.	Gangliosides	68-79	amyloid beta precursor protein	Rattus norvegicus	13-18
35442154-2	2022	Previously, we showed that C. jejuni isolates from human enteritis patients induced Type1/17-cytokine dependent colitis in interleukin-10 (IL-10)-/- mice, while isolates from GBS patients colonized these mice without colitis but instead induced autoantibodies that cross-reacted with the sialylated oligosaccharide motifs on the LOS of GBS-associated C. jejuni and the peripheral nerve gangliosides.	Gangliosides	386-398	interleukin 10	Homo sapiens	139-144