PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31932477-8	2020	To evaluate whether pharmacological induction of Nrf2 elicits beneficial effects for AD treatment, we tested the natural compound 6-MSITC [6-(methylsulfinyl)hexyl isothiocyanate].	6-msitc	130-137	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
27911093-9	2017	Interestingly, 6-MSITC exhibited the most potent effect toward Nrf2-mediated pathway.	6-msitc	15-22	NFE2 like bZIP transcription factor 2	Homo sapiens	63-67
27911093-10	2017	Our data suggest that 6-MSITC could exert chemopreventive role against cancer through its underlying antioxidant activity via the activation of Nrf2-mediated subsequent induction of cytoprotective genes.	6-msitc	22-29	NFE2 like bZIP transcription factor 2	Homo sapiens	144-148
23760613-10	2014	6-MSITC markedly attenuated TNF-alpha-induced adhesion of human monoblast U937 cells to HUVECs and reduced vascular cell adhesion molecule-1 and E-selectin mRNA expression in activated ECs.	6-msitc	0-7	tumor necrosis factor	Homo sapiens	28-37
23760613-10	2014	6-MSITC markedly attenuated TNF-alpha-induced adhesion of human monoblast U937 cells to HUVECs and reduced vascular cell adhesion molecule-1 and E-selectin mRNA expression in activated ECs.	6-msitc	0-7	vascular cell adhesion molecule 1	Homo sapiens	107-140
23760613-10	2014	6-MSITC markedly attenuated TNF-alpha-induced adhesion of human monoblast U937 cells to HUVECs and reduced vascular cell adhesion molecule-1 and E-selectin mRNA expression in activated ECs.	6-msitc	0-7	selectin E	Homo sapiens	145-155
24895898-5	2014	DNA fragmentation, DNA ladder, and caspase 3/7 activity performed in vitro revealed that 6-MSITC induced apoptosis of MDA-MB-231, MDA-MB-453, and MCF-7 cells.	6-msitc	89-96	caspase 3	Homo sapiens	35-44
24895898-6	2014	Furthermore, nuclear factor-kappaB (NF-kappaB) expression in the nuclei and phosphorylation of inhibitor kappaBalpha (IkappaBalpha) was downregulated by 6-MSITC in a concentration-dependent manner; however, this activity was not observed in MCF-7 cells.	6-msitc	153-160	nuclear factor kappa B subunit 1	Homo sapiens	13-34
24895898-6	2014	Furthermore, nuclear factor-kappaB (NF-kappaB) expression in the nuclei and phosphorylation of inhibitor kappaBalpha (IkappaBalpha) was downregulated by 6-MSITC in a concentration-dependent manner; however, this activity was not observed in MCF-7 cells.	6-msitc	153-160	nuclear factor kappa B subunit 1	Homo sapiens	36-45
24895898-6	2014	Furthermore, nuclear factor-kappaB (NF-kappaB) expression in the nuclei and phosphorylation of inhibitor kappaBalpha (IkappaBalpha) was downregulated by 6-MSITC in a concentration-dependent manner; however, this activity was not observed in MCF-7 cells.	6-msitc	153-160	NFKB inhibitor alpha	Homo sapiens	118-130
24895898-7	2014	Moreover, this downregulation of phosphorylated IkappaBalpha by 6-MSITC in MDA-MB-231 and -453 cells supports its inhibitory effects on NF-kappaB activity.	6-msitc	64-71	NFKB inhibitor alpha	Homo sapiens	48-60
24895898-7	2014	Moreover, this downregulation of phosphorylated IkappaBalpha by 6-MSITC in MDA-MB-231 and -453 cells supports its inhibitory effects on NF-kappaB activity.	6-msitc	64-71	nuclear factor kappa B subunit 1	Homo sapiens	136-145