PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25855335-0	2015	Intracolonic Administration of the TRPA1 Agonist Allyl Isothiocyanate Stimulates Colonic Motility and Defecation in Conscious Dogs.	allyl isothiocyanate	49-69	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	35-40
26238178-7	2015	It has been revealed that intracellular Ca2+ increase responses evoked by the TRPV1 agonist capsaicin, the TRPA1 agonsits allyl isothiocyanate (AITC) and formaldehyde as well as the TRPM8 activator icilin were inhibited after SMase, MCD and myriocin incubation but the response to the TRPM3 agonist pregnenolon sulphate was not altered.	allyl isothiocyanate	122-142	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	78-83
26238178-7	2015	It has been revealed that intracellular Ca2+ increase responses evoked by the TRPV1 agonist capsaicin, the TRPA1 agonsits allyl isothiocyanate (AITC) and formaldehyde as well as the TRPM8 activator icilin were inhibited after SMase, MCD and myriocin incubation but the response to the TRPM3 agonist pregnenolon sulphate was not altered.	allyl isothiocyanate	122-142	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily A member 1	Cricetulus griseus	107-112
26238178-7	2015	It has been revealed that intracellular Ca2+ increase responses evoked by the TRPV1 agonist capsaicin, the TRPA1 agonsits allyl isothiocyanate (AITC) and formaldehyde as well as the TRPM8 activator icilin were inhibited after SMase, MCD and myriocin incubation but the response to the TRPM3 agonist pregnenolon sulphate was not altered.	allyl isothiocyanate	144-148	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	78-83
26238178-7	2015	It has been revealed that intracellular Ca2+ increase responses evoked by the TRPV1 agonist capsaicin, the TRPA1 agonsits allyl isothiocyanate (AITC) and formaldehyde as well as the TRPM8 activator icilin were inhibited after SMase, MCD and myriocin incubation but the response to the TRPM3 agonist pregnenolon sulphate was not altered.	allyl isothiocyanate	144-148	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily A member 1	Cricetulus griseus	107-112
26066520-6	2015	2-Propenylisothiocyanate and 3-butenylisothiocyanate both inhibited cytochome P450 1A (CYP1A) enzyme activity in CYP expressing MCL-5 cells at high cytotoxic doses.	allyl isothiocyanate	0-24	peptidylprolyl isomerase G	Homo sapiens	87-90
26238178-9	2015	Besides the cell bodies, SMase also inhibited capsaicin- or AITC-evoked CGRP release from peripheral sensory nerve terminals, this provides the first evidence for the importance of lipid raft integrity in TRPV1 and TRPA1 gating on capsaicin-sensitive nerve terminals.	allyl isothiocyanate	60-64	calcitonin-related polypeptide alpha	Rattus norvegicus	72-76
26238178-9	2015	Besides the cell bodies, SMase also inhibited capsaicin- or AITC-evoked CGRP release from peripheral sensory nerve terminals, this provides the first evidence for the importance of lipid raft integrity in TRPV1 and TRPA1 gating on capsaicin-sensitive nerve terminals.	allyl isothiocyanate	60-64	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	205-210
26238178-9	2015	Besides the cell bodies, SMase also inhibited capsaicin- or AITC-evoked CGRP release from peripheral sensory nerve terminals, this provides the first evidence for the importance of lipid raft integrity in TRPV1 and TRPA1 gating on capsaicin-sensitive nerve terminals.	allyl isothiocyanate	60-64	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily A member 1	Cricetulus griseus	215-220
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	90-110	protein kinase C epsilon	Homo sapiens	40-50
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	90-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	141-146
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	90-110	protein kinase C epsilon	Homo sapiens	222-232
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	90-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	237-242
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	112-116	protein kinase C epsilon	Homo sapiens	40-50
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	112-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	141-146
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	112-116	protein kinase C epsilon	Homo sapiens	222-232
26171233-7	2015	In F-11 cells containing both channels, PKCepsilon inhibition prevented the propofol- and allyl isothiocyanate (AITC)-induced restoration of TRPV1 sensitivity to agonist stimulation as well as increased phosphorylation of PKCepsilon and TRPV1.	allyl isothiocyanate	112-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	237-242
26171233-9	2015	Moreover, NOS inhibition blocked propofol-and AITC-induced restoration of TRPV1 sensitivity and PKCepsilon phosphorylation, and PKCepsilon inhibition prevented the nitric oxide donor, SNAP, from restoring TRPV1 sensitivity.	allyl isothiocyanate	46-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
26171233-9	2015	Moreover, NOS inhibition blocked propofol-and AITC-induced restoration of TRPV1 sensitivity and PKCepsilon phosphorylation, and PKCepsilon inhibition prevented the nitric oxide donor, SNAP, from restoring TRPV1 sensitivity.	allyl isothiocyanate	46-50	protein kinase C epsilon	Homo sapiens	96-106
26171233-9	2015	Moreover, NOS inhibition blocked propofol-and AITC-induced restoration of TRPV1 sensitivity and PKCepsilon phosphorylation, and PKCepsilon inhibition prevented the nitric oxide donor, SNAP, from restoring TRPV1 sensitivity.	allyl isothiocyanate	46-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	205-210
26171233-10	2015	Also, propofol-and AITC-induced phosphorylation of nNOS and nitric oxide (NO) production were blocked with the TRPA1-antagonist, HC-030031.	allyl isothiocyanate	19-23	nitric oxide synthase 1	Homo sapiens	51-55
26171233-10	2015	Also, propofol-and AITC-induced phosphorylation of nNOS and nitric oxide (NO) production were blocked with the TRPA1-antagonist, HC-030031.	allyl isothiocyanate	19-23	transient receptor potential cation channel subfamily A member 1	Homo sapiens	111-116
26396928-3	2015	Our study revealed that cisplatin and AITC combination synergistically inhibits cancer cell growth and colony formation, and enhances apoptosis in association with the downregulation of antiapoptotic proteins Bcl-2 and survivin.	allyl isothiocyanate	38-42	BCL2 apoptosis regulator	Homo sapiens	209-214
26217204-7	2015	Intrarectal allyl isothiocyanate (AITC) evoked aversive behavior (freezing, reduction of locomotion and exploration) in association with p42/44 MAPK and c-Fos activation in spinal cord and brain.	allyl isothiocyanate	12-32	cyclin-dependent kinase 20	Mus musculus	137-140
26217204-7	2015	Intrarectal allyl isothiocyanate (AITC) evoked aversive behavior (freezing, reduction of locomotion and exploration) in association with p42/44 MAPK and c-Fos activation in spinal cord and brain.	allyl isothiocyanate	12-32	FBJ osteosarcoma oncogene	Mus musculus	153-158
26217204-7	2015	Intrarectal allyl isothiocyanate (AITC) evoked aversive behavior (freezing, reduction of locomotion and exploration) in association with p42/44 MAPK and c-Fos activation in spinal cord and brain.	allyl isothiocyanate	34-38	cyclin-dependent kinase 20	Mus musculus	137-140
26217204-7	2015	Intrarectal allyl isothiocyanate (AITC) evoked aversive behavior (freezing, reduction of locomotion and exploration) in association with p42/44 MAPK and c-Fos activation in spinal cord and brain.	allyl isothiocyanate	34-38	FBJ osteosarcoma oncogene	Mus musculus	153-158
25896791-3	2015	RESULTS: The application of allyl isothiocyanate (AITC), a TRPA1 agonist, significantly increased the frequency and amplitude of inhibitory postsynaptic currents (IPSCs; holding potential (VH) = 0 mV) as well as excitatory postsynaptic currents (EPSCs; VH = -70 mV) in substantia gelatinosa (SG) neurons.	allyl isothiocyanate	28-48	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	59-64
25978436-9	2015	Although the five active compounds showed weaker calcium responses than allyl isothiocyanate (EC50=7.2+-1.4 muM), our results suggest that these compounds from the stem and leaves of A.rugosa are specific and selective agonists of hTRPA1.	allyl isothiocyanate	72-92	transient receptor potential cation channel subfamily A member 1	Homo sapiens	231-237
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	allyl isothiocyanate	242-262	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	136-141
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	allyl isothiocyanate	242-262	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-151
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	allyl isothiocyanate	264-268	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	136-141
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	allyl isothiocyanate	264-268	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-151
25776458-3	2015	GER+MYR was more potent at enhancing the nuclear Nrf2 levels than were the following myrosinase-treated glucosinolates: sinigrin, glucoraphanin and gluconasturtiin, which are the precursors of allyl-ITC, R-sulforaphane and 2-phenylethyl ITC, respectively.	allyl isothiocyanate	193-202	nuclear factor, erythroid derived 2, like 2	Mus musculus	49-53
25896791-3	2015	RESULTS: The application of allyl isothiocyanate (AITC), a TRPA1 agonist, significantly increased the frequency and amplitude of inhibitory postsynaptic currents (IPSCs; holding potential (VH) = 0 mV) as well as excitatory postsynaptic currents (EPSCs; VH = -70 mV) in substantia gelatinosa (SG) neurons.	allyl isothiocyanate	50-54	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	59-64
25498793-4	2015	Nerve injury also sensitised mice to nociception, which was induced by the intraplantar injection of a low dose of the TRPA1 agonist allyl isothiocyanate without changing TRPA1 immunoreactivity in the injected paw.	allyl isothiocyanate	133-153	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	119-124
25642661-10	2015	Conversely, pretreatment with tramadol (0.1-10 muM) and M1 (1-10 muM) significantly suppressed the AITC-induced [Ca]i increases in HEK293 cells expressing hTRPA1.	allyl isothiocyanate	99-103	latexin	Homo sapiens	47-50
25642661-10	2015	Conversely, pretreatment with tramadol (0.1-10 muM) and M1 (1-10 muM) significantly suppressed the AITC-induced [Ca]i increases in HEK293 cells expressing hTRPA1.	allyl isothiocyanate	99-103	latexin	Homo sapiens	65-68
25642661-10	2015	Conversely, pretreatment with tramadol (0.1-10 muM) and M1 (1-10 muM) significantly suppressed the AITC-induced [Ca]i increases in HEK293 cells expressing hTRPA1.	allyl isothiocyanate	99-103	transient receptor potential cation channel subfamily A member 1	Homo sapiens	155-161
25325736-4	2015	Calcium imaging of primary L cells and the model cell line GLUTag revealed responses triggered by the TRPA1 agonists allyl-isothiocyanate (mustard oil), carvacrol, and polyunsaturated fatty acids, which were blocked by TRPA1 antagonists.	allyl isothiocyanate	117-137	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	102-107
25325736-4	2015	Calcium imaging of primary L cells and the model cell line GLUTag revealed responses triggered by the TRPA1 agonists allyl-isothiocyanate (mustard oil), carvacrol, and polyunsaturated fatty acids, which were blocked by TRPA1 antagonists.	allyl isothiocyanate	117-137	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	219-224
25591867-8	2015	TRPA1 agonist allyl isothiocyanate (AITC)-induced calcium influx in nodose and jugular neurons was significantly increased, and current densities in esophageal DiI-labeled nodose and jugular neurons were also significantly increased in antigen-challenged animals.	allyl isothiocyanate	14-34	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	0-5
25591867-8	2015	TRPA1 agonist allyl isothiocyanate (AITC)-induced calcium influx in nodose and jugular neurons was significantly increased, and current densities in esophageal DiI-labeled nodose and jugular neurons were also significantly increased in antigen-challenged animals.	allyl isothiocyanate	36-40	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	0-5
25771977-6	2015	Gene expression profiles revealed increased S100P and BAX and decreased BCL2 expression in RT4 cells following AITC treatment.	allyl isothiocyanate	111-115	S100 calcium binding protein P	Homo sapiens	44-49
25587718-6	2015	Modeling thermal hyperalgesia, the addition of the noxious inflammatory compound and TRPA1 agonist allyl isothiocyanate sensitized heat aversion and reversed cool aversion leading larvae to avoid rearing temperature in favor of otherwise acutely aversive cooler temperatures.	allyl isothiocyanate	99-119	transient receptor potential cation channel, subfamily A, member 1a	Danio rerio	85-90
25069801-6	2015	AITC-mediated reduction in the transcriptional activity of PXR and CAR correlated well with the suppression of CYP3A4 and CYP2B6 expression in HepG2 cells, which reflected the reduced catalytic activities of both of these genes following AITC treatment in differentiated HepaRG cells.	allyl isothiocyanate	0-4	nuclear receptor subfamily 1 group I member 2	Homo sapiens	59-62
25069801-6	2015	AITC-mediated reduction in the transcriptional activity of PXR and CAR correlated well with the suppression of CYP3A4 and CYP2B6 expression in HepG2 cells, which reflected the reduced catalytic activities of both of these genes following AITC treatment in differentiated HepaRG cells.	allyl isothiocyanate	0-4	nuclear receptor subfamily 1 group I member 3	Homo sapiens	67-70
25069801-6	2015	AITC-mediated reduction in the transcriptional activity of PXR and CAR correlated well with the suppression of CYP3A4 and CYP2B6 expression in HepG2 cells, which reflected the reduced catalytic activities of both of these genes following AITC treatment in differentiated HepaRG cells.	allyl isothiocyanate	0-4	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-117
25069801-6	2015	AITC-mediated reduction in the transcriptional activity of PXR and CAR correlated well with the suppression of CYP3A4 and CYP2B6 expression in HepG2 cells, which reflected the reduced catalytic activities of both of these genes following AITC treatment in differentiated HepaRG cells.	allyl isothiocyanate	0-4	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	122-128
25069801-8	2015	Furthermore, the antagonist effect of AITC against PXR was found in HepaRG cells upon addition of acetaminophen (APAP) and amiodarone, indicating that AITC protects cells from drug-induced cytotoxicity.	allyl isothiocyanate	38-42	nuclear receptor subfamily 1 group I member 2	Homo sapiens	51-54
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	0-20	nuclear receptor subfamily 1 group I member 2	Homo sapiens	37-56
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	0-20	nuclear receptor subfamily 1 group I member 2	Homo sapiens	58-61
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	0-20	nuclear receptor subfamily 1 group I member 3	Homo sapiens	67-99
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	0-20	nuclear receptor subfamily 1 group I member 3	Homo sapiens	101-104
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	22-26	nuclear receptor subfamily 1 group I member 2	Homo sapiens	37-56
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	22-26	nuclear receptor subfamily 1 group I member 2	Homo sapiens	58-61
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	22-26	nuclear receptor subfamily 1 group I member 3	Homo sapiens	67-99
25069801-0	2015	Allyl isothiocyanate (AITC) inhibits pregnane X receptor (PXR) and constitutive androstane receptor (CAR) activation and protects against acetaminophen- and amiodarone-induced cytotoxicity.	allyl isothiocyanate	22-26	nuclear receptor subfamily 1 group I member 3	Homo sapiens	101-104
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	51-71	nuclear receptor subfamily 1 group I member 2	Homo sapiens	142-161
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	51-71	nuclear receptor subfamily 1, group I, member 2	Mus musculus	163-166
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	51-71	nuclear receptor subfamily 1, group I, member 2	Mus musculus	168-173
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	51-71	nuclear receptor subfamily 1, group I, member 3	Mus musculus	179-211
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	51-71	nuclear receptor subfamily 1, group I, member 3	Mus musculus	213-216
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	51-71	nuclear receptor subfamily 1, group I, member 3	Mus musculus	218-223
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	73-77	nuclear receptor subfamily 1 group I member 2	Homo sapiens	142-161
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	73-77	nuclear receptor subfamily 1, group I, member 2	Mus musculus	163-166
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	73-77	nuclear receptor subfamily 1, group I, member 2	Mus musculus	168-173
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	73-77	nuclear receptor subfamily 1, group I, member 3	Mus musculus	179-211
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	73-77	nuclear receptor subfamily 1, group I, member 3	Mus musculus	213-216
25069801-2	2015	We identified a widely distributed isothiocyanate, allyl isothiocyanate (AITC), which acts as an effective antagonist of the nuclear receptor pregnane X receptor (PXR, NR1I2) and constitutive androstane receptor (CAR, NR1I3).	allyl isothiocyanate	73-77	nuclear receptor subfamily 1, group I, member 3	Mus musculus	218-223
25069801-5	2015	Protective effects of AITC on rifampin-induced cytotoxicity were observed, and transient transfection assays showed that AITC was able to effectively attenuate the agonist effects of rifampin and CITCO on human PXR and CAR activity, respectively.	allyl isothiocyanate	121-125	nuclear receptor subfamily 1 group I member 2	Homo sapiens	211-214
25069801-5	2015	Protective effects of AITC on rifampin-induced cytotoxicity were observed, and transient transfection assays showed that AITC was able to effectively attenuate the agonist effects of rifampin and CITCO on human PXR and CAR activity, respectively.	allyl isothiocyanate	121-125	nuclear receptor subfamily 1 group I member 3	Homo sapiens	219-222
25771977-6	2015	Gene expression profiles revealed increased S100P and BAX and decreased BCL2 expression in RT4 cells following AITC treatment.	allyl isothiocyanate	111-115	BCL2 associated X, apoptosis regulator	Homo sapiens	54-57
25771977-6	2015	Gene expression profiles revealed increased S100P and BAX and decreased BCL2 expression in RT4 cells following AITC treatment.	allyl isothiocyanate	111-115	BCL2 apoptosis regulator	Homo sapiens	72-76
25172898-10	2014	Allyl isothiocyanate, a selective TRPA1 agonist, increased Ca(2+) entry.	allyl isothiocyanate	0-20	transient receptor potential cation channel subfamily A member 1	Homo sapiens	34-39
26273426-0	2015	Upregulation of Multidrug Resistance-Associated Protein 1 by Allyl Isothiocyanate in Human Bronchial Epithelial Cell: Involvement of c-Jun N-Terminal Kinase Signaling Pathway.	allyl isothiocyanate	61-81	ATP binding cassette subfamily C member 1	Homo sapiens	16-57
26273426-3	2015	Our previous study showed that Allyl isothiocyanate (AITC) induced the expression and activity of MRP1 in a dose-dependent manner.	allyl isothiocyanate	31-51	ATP binding cassette subfamily C member 1	Homo sapiens	98-102
26273426-3	2015	Our previous study showed that Allyl isothiocyanate (AITC) induced the expression and activity of MRP1 in a dose-dependent manner.	allyl isothiocyanate	53-57	ATP binding cassette subfamily C member 1	Homo sapiens	98-102
25446932-5	2014	In addition, allylisothiocyanate, a TRPA1 agonist, but not (2S,5R)-2-Isopropyl-N-(4-methoxyphenyl)-5-methylcyclohexanecarboximide, a selective TRPM8 agonist, induced gastric relaxation.	allyl isothiocyanate	13-32	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	36-41
24953819-3	2014	A novel azabenzofuran series was developed that demonstrated in vitro inhibition of allyl isothiocyanate (AITC)-induced (45)Ca(2+) uptake with nanomolar potencies against both human and rat TRPA1.	allyl isothiocyanate	84-104	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	190-195
24815021-6	2014	Further experiments showed that cold-sensing transient receptor potential subfamily member 1 (TRPA1) channel agonist (allyl isothiocyanate, AITC) increased the production of NO and the level of [Ca(2+)]c in A549 cell.	allyl isothiocyanate	118-138	transient receptor potential cation channel subfamily A member 1	Homo sapiens	94-99
25062738-10	2014	The TRPA1 agonists allyl isothiocyanate and cinnamaldehyde and the TRPV4 agonist GSK1016790A caused a concentration-dependent increase in intracellular Ca(2+) concentration that was inhibited by the selective antagonists HC030031, AP18, and HC067047, respectively.	allyl isothiocyanate	19-39	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-9
25046327-1	2014	The presence of antinutritional constituents in rapeseed protein products (RPI), such as polyphenols, phytates, allyl isothiocyanates, and glucosinolates, is a formidable constraint.	allyl isothiocyanate	112-133	ribose 5-phosphate isomerase A	Homo sapiens	75-78
24953819-3	2014	A novel azabenzofuran series was developed that demonstrated in vitro inhibition of allyl isothiocyanate (AITC)-induced (45)Ca(2+) uptake with nanomolar potencies against both human and rat TRPA1.	allyl isothiocyanate	106-110	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	190-195
24893987-2	2014	Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and pain behaviors in rodents.	allyl isothiocyanate	60-80	transient receptor potential cation channel subfamily A member 1	Homo sapiens	12-17
24893987-2	2014	Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and pain behaviors in rodents.	allyl isothiocyanate	82-86	transient receptor potential cation channel subfamily A member 1	Homo sapiens	12-17
25197954-0	2014	Inhibition of cytochrome P450 2C9 expression and activity in vitro by allyl isothiocyanate.	allyl isothiocyanate	70-90	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	14-33
25197954-4	2014	In this study, we found that allyl isothiocyanate reduced catalytic activity, messenger ribonucleic acid, and protein expression of cytochrome P450 2C9 in HepaRG cells.	allyl isothiocyanate	29-49	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	132-151
25197954-6	2014	The decrease of cytochrome P450 2C9 expression and activity mediated by allyl isothiocyanate suggested that this agent could alter the metabolism of drugs metabolized by cytochrome P450 2C9.	allyl isothiocyanate	72-92	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	16-35
25197954-6	2014	The decrease of cytochrome P450 2C9 expression and activity mediated by allyl isothiocyanate suggested that this agent could alter the metabolism of drugs metabolized by cytochrome P450 2C9.	allyl isothiocyanate	72-92	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	170-189
24374060-5	2014	Following paclitaxel treatment, the release of CGRP was determined using capsaicin, a TRPV1 agonist; allyl isothiocyanate (AITC), a TRPA1 agonist; or high extracellular potassium.	allyl isothiocyanate	101-121	calcitonin-related polypeptide alpha	Rattus norvegicus	47-51
24980285-3	2014	In the in vitro study using platelet-rich plasma (PRP) from rats and humans, AITC at concentrations of 100 and 300 muM significantly inhibited platelet aggregation induced by collagen, thrombin, ADP, and arachidonic acid.	allyl isothiocyanate	77-81	proline rich protein 2-like 1	Rattus norvegicus	50-53
24980285-3	2014	In the in vitro study using platelet-rich plasma (PRP) from rats and humans, AITC at concentrations of 100 and 300 muM significantly inhibited platelet aggregation induced by collagen, thrombin, ADP, and arachidonic acid.	allyl isothiocyanate	77-81	coagulation factor II, thrombin	Homo sapiens	185-193
24726707-12	2014	LPP1 reduced pain induced by capsaicin (51%; p<0.01) and AITC (41%; p<0.05).	allyl isothiocyanate	60-64	phospholipid phosphatase 1	Mus musculus	0-4
24707974-8	2014	Nrf2 down-stream molecules including HO-1 and GCL were elevated by ACE or AITC treatment in MG-induced Neuro-2A cells.	allyl isothiocyanate	74-78	nuclear factor, erythroid derived 2, like 2	Mus musculus	0-4
24707974-8	2014	Nrf2 down-stream molecules including HO-1 and GCL were elevated by ACE or AITC treatment in MG-induced Neuro-2A cells.	allyl isothiocyanate	74-78	germ cell-less, spermatogenesis associated 1	Mus musculus	46-49
24172941-3	2013	Using behavioral testing, we found that TRPA1 knockout mice failed to avoid entering a chamber filled with vapor of formalin, allyl isothiocyanate, and acrolein.	allyl isothiocyanate	126-146	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	40-45
23955021-0	2014	Allyl isothiocyanate sensitizes TRPV1 to heat stimulation.	allyl isothiocyanate	0-20	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	32-37
23955021-4	2014	Patch-clamp recordings and intracellular Ca(2+) imaging experiments in HEK293T cells over-expressing mouse TRPV1 revealed that the increase in channel activation induced by heating is larger in the presence of AITC than in control conditions.	allyl isothiocyanate	210-214	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
24784702-6	2014	Application of menthol, a TRPA1/TRPM8 agonist, or allyl isothiocyanate (AITC), a selective TRPA1 agonist, to the hind paw of oxaliplatin-treated rats enhanced the nocifensive behaviors evoked by each agonist, whereas oxaliplatin had no significant effect on nocifensive behaviors evoked by capsaicin, a TRPV1 agonist.	allyl isothiocyanate	50-70	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	91-96
24784702-6	2014	Application of menthol, a TRPA1/TRPM8 agonist, or allyl isothiocyanate (AITC), a selective TRPA1 agonist, to the hind paw of oxaliplatin-treated rats enhanced the nocifensive behaviors evoked by each agonist, whereas oxaliplatin had no significant effect on nocifensive behaviors evoked by capsaicin, a TRPV1 agonist.	allyl isothiocyanate	50-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	303-308
24672635-0	2014	Allyl isothiocyanate increases MRP1 function and expression in a human bronchial epithelial cell line.	allyl isothiocyanate	0-20	ATP binding cassette subfamily C member 1	Homo sapiens	31-35
24672635-2	2014	The present study investigates the effects of allyl isothiocyanate (AITC) on MRP1 mRNA and MRP1 protein expression and transporter activity in the immortalised human bronchial epithelial cell line 16HBE14o-.	allyl isothiocyanate	46-66	ATP binding cassette subfamily C member 1	Homo sapiens	77-81
24672635-2	2014	The present study investigates the effects of allyl isothiocyanate (AITC) on MRP1 mRNA and MRP1 protein expression and transporter activity in the immortalised human bronchial epithelial cell line 16HBE14o-.	allyl isothiocyanate	68-72	ATP binding cassette subfamily C member 1	Homo sapiens	77-81
24672635-2	2014	The present study investigates the effects of allyl isothiocyanate (AITC) on MRP1 mRNA and MRP1 protein expression and transporter activity in the immortalised human bronchial epithelial cell line 16HBE14o-.	allyl isothiocyanate	68-72	ATP binding cassette subfamily C member 1	Homo sapiens	91-95
24672635-3	2014	MRP1 mRNA and MRP1 protein expression in 16HBE14o- cells that were treated with allyl isothiocyanate were analysed by real-time PCR assay and Western blotting.	allyl isothiocyanate	80-100	ATP binding cassette subfamily C member 1	Homo sapiens	0-4
24672635-3	2014	MRP1 mRNA and MRP1 protein expression in 16HBE14o- cells that were treated with allyl isothiocyanate were analysed by real-time PCR assay and Western blotting.	allyl isothiocyanate	80-100	ATP binding cassette subfamily C member 1	Homo sapiens	14-18
24027177-8	2013	Interestingly, application of etodolac at drug plasma levels in clinical usage did not induce significant TRPA1 currents but reduced the subsequent AITC-induced currents to 25% in HEK293 cells expressing TRPA1.	allyl isothiocyanate	148-152	transient receptor potential cation channel subfamily A member 1	Homo sapiens	204-209
24830023-5	2014	The thermosensitive transient receptor potential (TRP) channels TRPV1 and TRPA1, which bind capsaicin and allyl isothiocyanate (mustard oil), respectively, are important for pain transmission.	allyl isothiocyanate	106-126	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	64-69
24830023-5	2014	The thermosensitive transient receptor potential (TRP) channels TRPV1 and TRPA1, which bind capsaicin and allyl isothiocyanate (mustard oil), respectively, are important for pain transmission.	allyl isothiocyanate	106-126	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	74-79
24270601-7	2014	Thus, the metastatic responses in AITC-treated HT29 cells after EGF stimulation were mediated by the MMP-2/-9 and MAPK signaling pathways.	allyl isothiocyanate	34-38	matrix metallopeptidase 2	Homo sapiens	101-109
24270601-9	2014	In summary, it is possible that AITC suppresses the invasion and migration of EGF-induced HT29 cells, resulting from MMP-2/-9 and MAPKs.	allyl isothiocyanate	32-36	matrix metallopeptidase 2	Homo sapiens	117-125
23994502-6	2013	Furthermore, stimulating A549 cells with known TRPA1 activators (i.e., allyl isothiocyanate) led to an increase in intracellular calcium levels, which was sensitive to the TRPA1 blocker ruthenium red.	allyl isothiocyanate	71-91	transient receptor potential cation channel subfamily A member 1	Homo sapiens	47-52
23994502-6	2013	Furthermore, stimulating A549 cells with known TRPA1 activators (i.e., allyl isothiocyanate) led to an increase in intracellular calcium levels, which was sensitive to the TRPA1 blocker ruthenium red.	allyl isothiocyanate	71-91	transient receptor potential cation channel subfamily A member 1	Homo sapiens	172-177
23657286-8	2013	TRPA1 agonist allyl isothiocyanate but not capsaicin inhibited the facilitatory effect of zingerone.	allyl isothiocyanate	14-34	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
23757176-0	2013	Mechanisms of transient receptor potential vanilloid 1 activation and sensitization by allyl isothiocyanate.	allyl isothiocyanate	87-107	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-54
23757176-4	2013	Here we show that, surprisingly, AITC-induced activation of TRPV1 does not require interaction with cysteine residues, but is largely dependent on S513, a residue that is involved in capsaicin binding.	allyl isothiocyanate	33-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-65
23757176-7	2013	In addition, we show that TRPV1 is a locus for cross-sensitization between AITC and acidosis in nociceptive neurons.	allyl isothiocyanate	75-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-31
24147119-1	2013	The transient receptor potential vanilloid receptor 1 (TRPV1) channel is a nonselective cation channel activated by a variety of exogenous and endogenous physical and chemical stimuli, such as temperature (>=42  C), capsaicin, a pungent compound in hot chili peppers, and allyl isothiocyanate.	allyl isothiocyanate	275-295	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-60
23895248-0	2013	Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway.	allyl isothiocyanate	55-75	Rho-associated coiled-coil containing protein kinase 1	Mus musculus	100-105
23895248-0	2013	Mitochondrial translocation of cofilin is required for allyl isothiocyanate-mediated cell death via ROCK1/PTEN/PI3K signaling pathway.	allyl isothiocyanate	55-75	phosphatase and tensin homolog	Mus musculus	106-110
22683866-4	2012	In conscious guinea pigs the TRPA1 agonist allyl-isothiocyanate (AITC) evoked cough with a maximally effective concentration of 10mM that was abolished by the selective TRPA1 antagonist AP-18.	allyl isothiocyanate	43-63	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	29-34
23685721-5	2013	However, silencing TRPV1(+) or TRPA1(+) neurons allowed allyl isothiocyanate or capsaicin, respectively, to evoke itch, implying that certain peripheral afferents may normally indirectly inhibit algogens from eliciting itch.	allyl isothiocyanate	56-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
23685721-5	2013	However, silencing TRPV1(+) or TRPA1(+) neurons allowed allyl isothiocyanate or capsaicin, respectively, to evoke itch, implying that certain peripheral afferents may normally indirectly inhibit algogens from eliciting itch.	allyl isothiocyanate	56-76	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
23477783-4	2013	Bortezomib evoked a prolonged mechanical, cold, and selective chemical hypersensitivity (the latter against the TRPA1 agonist allyl isothiocyanate).	allyl isothiocyanate	126-146	transient receptor potential cation channel subfamily A member 1	Homo sapiens	112-117
23413875-4	2013	RESULTS: We found that resveratrol dose-dependently suppressed the allyl isothiocyanate (AITC)-induced currents (I AITC) in HEK293 cells that express TRPA1, as well as in rat dorsal root ganglion (DRG) neurons.	allyl isothiocyanate	67-87	transient receptor potential cation channel subfamily A member 1	Homo sapiens	150-155
23413875-4	2013	RESULTS: We found that resveratrol dose-dependently suppressed the allyl isothiocyanate (AITC)-induced currents (I AITC) in HEK293 cells that express TRPA1, as well as in rat dorsal root ganglion (DRG) neurons.	allyl isothiocyanate	89-93	transient receptor potential cation channel subfamily A member 1	Homo sapiens	150-155
23008020-0	2012	ERK-modulated intrinsic signaling and G(2)/M phase arrest contribute to the induction of apoptotic death by allyl isothiocyanate in MDA-MB-468 human breast adenocarcinoma cells.	allyl isothiocyanate	108-128	mitogen-activated protein kinase 1	Homo sapiens	0-3
23008020-9	2012	Importantly, NAC (a ROS scavenger) and U0126 (an ERK inhibitor) abolished AITC-reduced viability in MDA-MB-468 cells.	allyl isothiocyanate	74-78	X-linked Kx blood group	Homo sapiens	13-16
23008020-9	2012	Importantly, NAC (a ROS scavenger) and U0126 (an ERK inhibitor) abolished AITC-reduced viability in MDA-MB-468 cells.	allyl isothiocyanate	74-78	mitogen-activated protein kinase 1	Homo sapiens	49-52
23008020-11	2012	In summary, our findings demonstrated that AITC-promoted G2/M phase and AITC-triggered apoptosis correlate with the activation of phosphorylation of ERK in MDA-MB-468 cells.	allyl isothiocyanate	43-47	mitogen-activated protein kinase 1	Homo sapiens	149-152
23413359-7	2013	TRPA1-selective agonists, allyl isothiocyanate and cinnamaldehyde, induced Ca(2+) influx, and responses to polysulfides were suppressed by TRPA1-selective inhibitors, HC-030031 and AP-18, as well as by siRNAs selective to TRPA1.	allyl isothiocyanate	26-46	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	139-144
23413359-7	2013	TRPA1-selective agonists, allyl isothiocyanate and cinnamaldehyde, induced Ca(2+) influx, and responses to polysulfides were suppressed by TRPA1-selective inhibitors, HC-030031 and AP-18, as well as by siRNAs selective to TRPA1.	allyl isothiocyanate	26-46	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	139-144
23521647-2	2013	The injection of allyl isothiocyanate (AITC, 50, 100, or 300 microg/paw) into the rat"s hind paw induced dose and time-dependent hyperalgesia and edema, which were blocked by the selective TRPA1 antagonist, HC 030031 (1,200 microg/paw), or by treatment with antisense oligodeoxynucleotide (four daily intrathecal injections of 5 nmol).	allyl isothiocyanate	17-37	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	189-194
23521647-2	2013	The injection of allyl isothiocyanate (AITC, 50, 100, or 300 microg/paw) into the rat"s hind paw induced dose and time-dependent hyperalgesia and edema, which were blocked by the selective TRPA1 antagonist, HC 030031 (1,200 microg/paw), or by treatment with antisense oligodeoxynucleotide (four daily intrathecal injections of 5 nmol).	allyl isothiocyanate	39-43	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	189-194
23219522-2	2013	TRPA1 is activated by toxic or irritating volatile agents like allyl isothiocyanate (AITC), tear gas, formalin, or cigarette smoke.	allyl isothiocyanate	63-83	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
23219522-2	2013	TRPA1 is activated by toxic or irritating volatile agents like allyl isothiocyanate (AITC), tear gas, formalin, or cigarette smoke.	allyl isothiocyanate	85-89	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
23219522-8	2013	Furthermore, AITC or formalin stimulated ERK1/2 in TRPA1-expressing HEK293 cells and in SCLC cells via a Src- and calcium-dependent mechanism.	allyl isothiocyanate	13-17	mitogen-activated protein kinase 3	Homo sapiens	41-47
23219522-8	2013	Furthermore, AITC or formalin stimulated ERK1/2 in TRPA1-expressing HEK293 cells and in SCLC cells via a Src- and calcium-dependent mechanism.	allyl isothiocyanate	13-17	transient receptor potential cation channel subfamily A member 1	Homo sapiens	51-56
23219522-8	2013	Furthermore, AITC or formalin stimulated ERK1/2 in TRPA1-expressing HEK293 cells and in SCLC cells via a Src- and calcium-dependent mechanism.	allyl isothiocyanate	13-17	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	105-108
23192000-7	2012	In addition, 1,8-cineole inhibited human TRPA1 currents activated by allyl isothiocyanate, menthol, fulfenamic acid or octanol in a dose-dependent manner.	allyl isothiocyanate	69-89	transient receptor potential cation channel subfamily A member 1	Homo sapiens	41-46
22721614-4	2012	AITC or NaHS were applied to the ears of Balb/c, C57BL/6, TRPA1 and TRPV1 receptor gene knockout mice and blood flow was detected by laser Doppler imaging.	allyl isothiocyanate	0-4	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	58-63
22721614-4	2012	AITC or NaHS were applied to the ears of Balb/c, C57BL/6, TRPA1 and TRPV1 receptor gene knockout mice and blood flow was detected by laser Doppler imaging.	allyl isothiocyanate	0-4	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	68-73
22683866-4	2012	In conscious guinea pigs the TRPA1 agonist allyl-isothiocyanate (AITC) evoked cough with a maximally effective concentration of 10mM that was abolished by the selective TRPA1 antagonist AP-18.	allyl isothiocyanate	43-63	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	169-174
22683866-4	2012	In conscious guinea pigs the TRPA1 agonist allyl-isothiocyanate (AITC) evoked cough with a maximally effective concentration of 10mM that was abolished by the selective TRPA1 antagonist AP-18.	allyl isothiocyanate	65-69	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	29-34
22683866-4	2012	In conscious guinea pigs the TRPA1 agonist allyl-isothiocyanate (AITC) evoked cough with a maximally effective concentration of 10mM that was abolished by the selective TRPA1 antagonist AP-18.	allyl isothiocyanate	65-69	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	169-174
21692985-0	2012	Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(kappa) B and microRNA-155.	allyl isothiocyanate	31-51	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
22839205-7	2012	The nocifensive behaviors evoked by intraplantar injections of allyl-isothiocyanate (AITC; TRPA1 agonist) were significantly enhanced in mice treated for 2 h with oxaliplatin (1-10 mg/kg) in a dose-dependent manner, while capsaicin (TRPV1 agonist)-evoked nocifensive behaviors were not affected.	allyl isothiocyanate	63-83	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	91-96
22839205-7	2012	The nocifensive behaviors evoked by intraplantar injections of allyl-isothiocyanate (AITC; TRPA1 agonist) were significantly enhanced in mice treated for 2 h with oxaliplatin (1-10 mg/kg) in a dose-dependent manner, while capsaicin (TRPV1 agonist)-evoked nocifensive behaviors were not affected.	allyl isothiocyanate	63-83	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	233-238
22839205-7	2012	The nocifensive behaviors evoked by intraplantar injections of allyl-isothiocyanate (AITC; TRPA1 agonist) were significantly enhanced in mice treated for 2 h with oxaliplatin (1-10 mg/kg) in a dose-dependent manner, while capsaicin (TRPV1 agonist)-evoked nocifensive behaviors were not affected.	allyl isothiocyanate	85-89	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	91-96
22839205-7	2012	The nocifensive behaviors evoked by intraplantar injections of allyl-isothiocyanate (AITC; TRPA1 agonist) were significantly enhanced in mice treated for 2 h with oxaliplatin (1-10 mg/kg) in a dose-dependent manner, while capsaicin (TRPV1 agonist)-evoked nocifensive behaviors were not affected.	allyl isothiocyanate	85-89	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	233-238
22668719-0	2012	Suppression of TRIF-dependent signaling pathway of toll-like receptors by allyl isothiocyanate in RAW 264.7 macrophages.	allyl isothiocyanate	74-94	TIR domain containing adaptor molecule 1	Homo sapiens	15-19
22671314-3	2012	Either allyl isothiocyanate(AITC) or cinnamaldehyde, other TRPA1 agonists, also increased mIPSC frequency, but the extent of facilitation induced by AITC or cinnamaldehyde was less than that induced by icilin.	allyl isothiocyanate	7-27	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	59-64
22207576-4	2012	In the present study, we investigated the secretory effect of the potential TRPA1 agonist allyl isothiocyanate (AITC) in rat and human colon using an Ussing chamber.	allyl isothiocyanate	90-110	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	76-81
22207576-4	2012	In the present study, we investigated the secretory effect of the potential TRPA1 agonist allyl isothiocyanate (AITC) in rat and human colon using an Ussing chamber.	allyl isothiocyanate	112-116	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	76-81
21692985-0	2012	Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(kappa) B and microRNA-155.	allyl isothiocyanate	31-51	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-79
21692985-0	2012	Anti-inflammatory potential of allyl-isothiocyanate--role of Nrf2, NF-(kappa) B and microRNA-155.	allyl isothiocyanate	31-51	microRNA 155	Mus musculus	84-96
21692985-9	2012	The anti-inflammatory effects of AITC were accompanied by an increase in Nrf2 nuclear translocation and consequently by an increase of mRNA and protein levels of the Nrf2 target gene heme-oxygenase 1.	allyl isothiocyanate	33-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
21692985-9	2012	The anti-inflammatory effects of AITC were accompanied by an increase in Nrf2 nuclear translocation and consequently by an increase of mRNA and protein levels of the Nrf2 target gene heme-oxygenase 1.	allyl isothiocyanate	33-37	nuclear factor, erythroid derived 2, like 2	Mus musculus	166-170
21692985-9	2012	The anti-inflammatory effects of AITC were accompanied by an increase in Nrf2 nuclear translocation and consequently by an increase of mRNA and protein levels of the Nrf2 target gene heme-oxygenase 1.	allyl isothiocyanate	33-37	heme oxygenase 1	Mus musculus	183-199
22131196-0	2012	Allyl isothiocyanate as a potential inducer of paraoxonase-1--studies in cultured hepatocytes and in mice.	allyl isothiocyanate	0-20	paraoxonase 1	Mus musculus	47-60
21955242-0	2012	Modulation of mouse gastrointestinal motility by allyl isothiocyanate, a constituent of cruciferous vegetables (Brassicaceae): evidence for TRPA1-independent effects.	allyl isothiocyanate	49-69	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	140-145
21955242-1	2012	BACKGROUND AND PURPOSE: Allyl isothiocyanate (AITC, mustard oil), a constituent of many common cruciferous vegetables (Brassicaceae), activates transient receptor potential of ankyrin type-1 (TRPA1) channels, claimed to regulate gastrointestinal contractility.	allyl isothiocyanate	24-44	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	192-197
21955242-1	2012	BACKGROUND AND PURPOSE: Allyl isothiocyanate (AITC, mustard oil), a constituent of many common cruciferous vegetables (Brassicaceae), activates transient receptor potential of ankyrin type-1 (TRPA1) channels, claimed to regulate gastrointestinal contractility.	allyl isothiocyanate	46-50	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	192-197
22182301-1	2012	To examine mechanisms underlying substance P (SP) release from primary sensory neurons in response to activation of the non-selective cation channel transient receptor potential ankyrin 1 (TRPA1), SP release from cultured rat dorsal root ganglion neurons was measured, using radioimmunoassay, by stimulating TRPA1 with allyl isothiocyanate (AITC), a TRPA1 agonist.	allyl isothiocyanate	319-339	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	189-194
22182301-1	2012	To examine mechanisms underlying substance P (SP) release from primary sensory neurons in response to activation of the non-selective cation channel transient receptor potential ankyrin 1 (TRPA1), SP release from cultured rat dorsal root ganglion neurons was measured, using radioimmunoassay, by stimulating TRPA1 with allyl isothiocyanate (AITC), a TRPA1 agonist.	allyl isothiocyanate	341-345	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	189-194
22182301-2	2012	AITC-evoked SP release occurred in a concentration- and time-dependent manner.	allyl isothiocyanate	0-4	tachykinin 1	Mus musculus	12-14
22182301-3	2012	Interestingly, p38 mitogen-activated protein kinase (p38) inhibitor SB203580 significantly attenuated AITC-evoked SP release.	allyl isothiocyanate	102-106	mitogen-activated protein kinase 14	Mus musculus	15-18
22182301-3	2012	Interestingly, p38 mitogen-activated protein kinase (p38) inhibitor SB203580 significantly attenuated AITC-evoked SP release.	allyl isothiocyanate	102-106	mitogen-activated protein kinase 14	Mus musculus	53-56
22182301-3	2012	Interestingly, p38 mitogen-activated protein kinase (p38) inhibitor SB203580 significantly attenuated AITC-evoked SP release.	allyl isothiocyanate	102-106	tachykinin 1	Mus musculus	114-116
22182301-4	2012	The in vivo effect of AITC-evoked SP release from primary sensory neurons in mice was evaluated.	allyl isothiocyanate	22-26	tachykinin 1	Mus musculus	34-36
22182301-8	2012	Immunohistochemical studies demonstrated that intraplantar AITC injection induced the phosphorylation of p38 in mouse dorsal root ganglion neurons containing SP.	allyl isothiocyanate	59-63	mitogen-activated protein kinase 14	Mus musculus	105-108
22182301-8	2012	Immunohistochemical studies demonstrated that intraplantar AITC injection induced the phosphorylation of p38 in mouse dorsal root ganglion neurons containing SP.	allyl isothiocyanate	59-63	tachykinin 1	Mus musculus	158-160
22131196-6	2012	Thus, it is suggested that AITC may be a potent inducer of PON1 in vitro, but not in mouse liver in vivo.	allyl isothiocyanate	27-31	paraoxonase 1	Mus musculus	59-63
22131196-2	2012	Allyl isothiocyanate (AITC), phenylethyl isothiocyanate (PEITC), and sulforaphane (SFN), but not butyl isothiocyanate (BITC) resulted in dose-dependent induction of PON1 transactivation in Huh7 cells in vitro.	allyl isothiocyanate	0-20	paraoxonase 1	Homo sapiens	165-169
22382320-8	2012	TRPA1 agonists, allylisothiocyanate and 15-deoxy-Delta(12,14)-prostaglandin J(2), significantly induced Ca(2+) influx, and a specific inhibitor TRPA1, HC-030031, blocked the effects elicited by 4-hydroxy-2-nonenal.	allyl isothiocyanate	16-35	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	144-149
22701540-9	2012	Activation of TRPA1 by allyl isothiocyanate (AITC), hydrogen peroxide (H2O2), 4-hydroxynonenal (4-HNE), and cyclopentenone prostaglandins (PGJ2) and a novel agonist methylglyoxal (MG) induces membrane current, depolarization, and Ca2+ influx leading to generation of action potentials in a pancreatic beta cell line and primary cultured pancreatic beta cells.	allyl isothiocyanate	23-43	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	14-19
22739568-0	2012	Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation.	allyl isothiocyanate	20-40	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	96-101
23133534-6	2012	Approximately 80% of all small-diameter (<27 microm) neurons from lumbar 1-6 DRGs that responded to TRPA1 agonists allyl isothiocyanate (AITC; 79%) or cinnamaldehyde (84%) were IB4-positive.	allyl isothiocyanate	118-138	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	103-108
23133534-6	2012	Approximately 80% of all small-diameter (<27 microm) neurons from lumbar 1-6 DRGs that responded to TRPA1 agonists allyl isothiocyanate (AITC; 79%) or cinnamaldehyde (84%) were IB4-positive.	allyl isothiocyanate	140-144	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	103-108
22701540-9	2012	Activation of TRPA1 by allyl isothiocyanate (AITC), hydrogen peroxide (H2O2), 4-hydroxynonenal (4-HNE), and cyclopentenone prostaglandins (PGJ2) and a novel agonist methylglyoxal (MG) induces membrane current, depolarization, and Ca2+ influx leading to generation of action potentials in a pancreatic beta cell line and primary cultured pancreatic beta cells.	allyl isothiocyanate	45-49	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	14-19
21962912-4	2011	Additionally, the agonists allyl isothiocyanate (TRPA1) and capsaicin (TRPV1) induce a differential secretion pattern of the eicosanoids PGE(2) and LTB(4) in human dermal fibroblasts and keratinocytes, which was also detectable invivo, analyzing suction blister fluid at various times after short-term topical application.	allyl isothiocyanate	27-47	transient receptor potential cation channel subfamily A member 1	Homo sapiens	49-54
22532928-5	2012	The TRPA1 agonist allyl isothiocyanate (AITC) induced inflammatory edema when injected intraplantarly to mice, mimicking the classical response to carrageenan.	allyl isothiocyanate	18-38	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	4-9
22532928-5	2012	The TRPA1 agonist allyl isothiocyanate (AITC) induced inflammatory edema when injected intraplantarly to mice, mimicking the classical response to carrageenan.	allyl isothiocyanate	40-44	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	4-9
22532928-6	2012	Interestingly, the TRPA1 antagonist HC-030031 and the cyclo-oxygenase (COX) inhibitor ibuprofen inhibited not only AITC but also carrageenan-induced edema.	allyl isothiocyanate	115-119	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	19-24
21962912-4	2011	Additionally, the agonists allyl isothiocyanate (TRPA1) and capsaicin (TRPV1) induce a differential secretion pattern of the eicosanoids PGE(2) and LTB(4) in human dermal fibroblasts and keratinocytes, which was also detectable invivo, analyzing suction blister fluid at various times after short-term topical application.	allyl isothiocyanate	27-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
22093285-10	2011	A HSP70 ELISA showed that AITC toxicity in C. elegans was ameliorated by the presence of ground seed from low sinigrin B. juncea cv.	allyl isothiocyanate	26-30	Heat Shock Protein	Caenorhabditis elegans	2-7
21867704-5	2011	The TRPV1 agonist capsaicin (CAPS, 1 muM) and the TRPA1 agonist allyl isothiocyanate (AITC, 30 muM), elicited excitatory effects in bladder strips, increasing basal tone and amplitude of phasic bladder contractions (PBC).	allyl isothiocyanate	64-84	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	50-55
21867704-5	2011	The TRPV1 agonist capsaicin (CAPS, 1 muM) and the TRPA1 agonist allyl isothiocyanate (AITC, 30 muM), elicited excitatory effects in bladder strips, increasing basal tone and amplitude of phasic bladder contractions (PBC).	allyl isothiocyanate	86-90	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	50-55
21972382-3	2011	Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) channels are nonselective cation channels that are activated by a range of natural products (eg, allyl isothiocyanate), a multitude of environmental irritants (eg, acrolein, which is present in air pollution, vehicle exhaust, and cigarette smoke), and inflammatory mediators (eg, cyclopentenone prostaglandins).	allyl isothiocyanate	172-192	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-66
21972382-3	2011	Transient receptor potential cation channel, subfamily A, member 1 (TRPA1) channels are nonselective cation channels that are activated by a range of natural products (eg, allyl isothiocyanate), a multitude of environmental irritants (eg, acrolein, which is present in air pollution, vehicle exhaust, and cigarette smoke), and inflammatory mediators (eg, cyclopentenone prostaglandins).	allyl isothiocyanate	172-192	transient receptor potential cation channel subfamily A member 1	Homo sapiens	68-73
21883700-6	2011	Single fiber recording showed that the TRPA1 agonists allyl-isothiocyanate (AITC) and cinnamaldehyde were effective in inducing robust action potential discharge in the nerve terminals of nodose nociceptors, but had far less effect in jugular nociceptors (approximately fivefold less).	allyl isothiocyanate	54-74	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	39-44
21848366-5	2011	TRPA1 selective agonists like allyl isothiocyanate (AITC), 4-hydroxynonenal (4-HNE), crotonaldehyde and zinc, induced a concentration-dependent increase in Ca+2 influx in CCD19-Lu and A549 cells.	allyl isothiocyanate	30-50	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
21848366-5	2011	TRPA1 selective agonists like allyl isothiocyanate (AITC), 4-hydroxynonenal (4-HNE), crotonaldehyde and zinc, induced a concentration-dependent increase in Ca+2 influx in CCD19-Lu and A549 cells.	allyl isothiocyanate	52-56	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
21883700-6	2011	Single fiber recording showed that the TRPA1 agonists allyl-isothiocyanate (AITC) and cinnamaldehyde were effective in inducing robust action potential discharge in the nerve terminals of nodose nociceptors, but had far less effect in jugular nociceptors (approximately fivefold less).	allyl isothiocyanate	76-80	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	39-44
21051219-7	2011	We have chosen TRPA1 from the TRPA ("ankyrin") family as a model channel which was stimulated by allyl isothiocyanate (AITC).	allyl isothiocyanate	97-117	transient receptor potential cation channel subfamily A member 1	Homo sapiens	15-20
21778226-0	2011	Allyl isothiocyanate arrests cancer cells in mitosis, and mitotic arrest in turn leads to apoptosis via Bcl-2 protein phosphorylation.	allyl isothiocyanate	0-20	BCL2 apoptosis regulator	Homo sapiens	104-109
21653898-5	2011	Whole cell TRPA1 currents induced by brief application of lower concentrations of N-methyl maleimide (NMM) or allyl isothiocyanate (AITC) can be reversed readily by washout, whereas continuous application of higher concentrations of NMM or AITC completely desensitized the currents.	allyl isothiocyanate	110-130	transient receptor potential cation channel subfamily A member 1	Homo sapiens	11-16
21653898-5	2011	Whole cell TRPA1 currents induced by brief application of lower concentrations of N-methyl maleimide (NMM) or allyl isothiocyanate (AITC) can be reversed readily by washout, whereas continuous application of higher concentrations of NMM or AITC completely desensitized the currents.	allyl isothiocyanate	132-136	transient receptor potential cation channel subfamily A member 1	Homo sapiens	11-16
21689654-9	2011	TRPA1 activators, including cinnamaldehyde, allyl isothiocyanate (AITC), and 4-hydroxynonenal, increased [Ca(2+)](i) in myenteric neurons.	allyl isothiocyanate	44-64	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
21689654-9	2011	TRPA1 activators, including cinnamaldehyde, allyl isothiocyanate (AITC), and 4-hydroxynonenal, increased [Ca(2+)](i) in myenteric neurons.	allyl isothiocyanate	66-70	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
21558163-7	2011	Seventy-three per cent of Trpa1+/+ small-diameter neurons responding to the TRPA1 agonist allyl-isothiocyanate (AITC) displayed IAMCs to neurite displacement, which were significantly enhanced after AITC addition.	allyl isothiocyanate	90-110	transient receptor potential cation channel subfamily A member 1	Homo sapiens	26-31
21558163-7	2011	Seventy-three per cent of Trpa1+/+ small-diameter neurons responding to the TRPA1 agonist allyl-isothiocyanate (AITC) displayed IAMCs to neurite displacement, which were significantly enhanced after AITC addition.	allyl isothiocyanate	90-110	transient receptor potential cation channel subfamily A member 1	Homo sapiens	76-81
21558163-7	2011	Seventy-three per cent of Trpa1+/+ small-diameter neurons responding to the TRPA1 agonist allyl-isothiocyanate (AITC) displayed IAMCs to neurite displacement, which were significantly enhanced after AITC addition.	allyl isothiocyanate	112-116	transient receptor potential cation channel subfamily A member 1	Homo sapiens	26-31
21558163-7	2011	Seventy-three per cent of Trpa1+/+ small-diameter neurons responding to the TRPA1 agonist allyl-isothiocyanate (AITC) displayed IAMCs to neurite displacement, which were significantly enhanced after AITC addition.	allyl isothiocyanate	112-116	transient receptor potential cation channel subfamily A member 1	Homo sapiens	76-81
21430076-0	2011	Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPA1 in mice.	allyl isothiocyanate	31-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	89-94
21430076-4	2011	Intragastric administration of allyl isothiocyanate (AITC; a typical TRPA1 agonist) markedly increased carbohydrate oxidation but did not affect oxygen consumption.	allyl isothiocyanate	31-51	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	69-74
21430076-4	2011	Intragastric administration of allyl isothiocyanate (AITC; a typical TRPA1 agonist) markedly increased carbohydrate oxidation but did not affect oxygen consumption.	allyl isothiocyanate	53-57	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	69-74
21619614-1	2011	BACKGROUND: The transient receptor potential (TRP) channel subtype A1 (TRPA1) is known to be expressed on sensory neurons and respond to changes in temperature, pH and local application of certain noxious chemicals such as allyl isothiocyanate (AITC).	allyl isothiocyanate	223-243	transient receptor potential cation channel subfamily A member 1	Homo sapiens	71-76
21619614-1	2011	BACKGROUND: The transient receptor potential (TRP) channel subtype A1 (TRPA1) is known to be expressed on sensory neurons and respond to changes in temperature, pH and local application of certain noxious chemicals such as allyl isothiocyanate (AITC).	allyl isothiocyanate	245-249	transient receptor potential cation channel subfamily A member 1	Homo sapiens	71-76
21364461-7	2011	RESULTS: In DRG neurons that contain both TRPV1 and TRPA1, propofol and AITC restored TRPV1 sensitivity.	allyl isothiocyanate	72-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
21364461-7	2011	RESULTS: In DRG neurons that contain both TRPV1 and TRPA1, propofol and AITC restored TRPV1 sensitivity.	allyl isothiocyanate	72-76	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	52-57
21364461-7	2011	RESULTS: In DRG neurons that contain both TRPV1 and TRPA1, propofol and AITC restored TRPV1 sensitivity.	allyl isothiocyanate	72-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
20135626-8	2011	In contrast, the application of TRPA1 agonist icilin or allyl isothiocyanate (AITC) led to a stronger neurodegeneration.	allyl isothiocyanate	56-76	transient receptor potential cation channel subfamily A member 1	Homo sapiens	32-37
20135626-8	2011	In contrast, the application of TRPA1 agonist icilin or allyl isothiocyanate (AITC) led to a stronger neurodegeneration.	allyl isothiocyanate	78-82	transient receptor potential cation channel subfamily A member 1	Homo sapiens	32-37
21364461-9	2011	Similarly, in F-11 cells transfected with both TRPV1 and TRPA1, propofol and AITC restored TRPV1 sensitivity.	allyl isothiocyanate	77-81	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	47-52
21364461-9	2011	Similarly, in F-11 cells transfected with both TRPV1 and TRPA1, propofol and AITC restored TRPV1 sensitivity.	allyl isothiocyanate	77-81	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	57-62
21364461-9	2011	Similarly, in F-11 cells transfected with both TRPV1 and TRPA1, propofol and AITC restored TRPV1 sensitivity.	allyl isothiocyanate	77-81	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	91-96
21316356-6	2011	To assess signaling, the TRPA1 selective agonist allyl isothiocyanate (AITC) was tested together with CCK and capsaicin (200nM), a TRPV1 specific agonist.	allyl isothiocyanate	49-69	transient receptor potential cation channel subfamily A member 1	Homo sapiens	25-30
21316356-6	2011	To assess signaling, the TRPA1 selective agonist allyl isothiocyanate (AITC) was tested together with CCK and capsaicin (200nM), a TRPV1 specific agonist.	allyl isothiocyanate	71-75	transient receptor potential cation channel subfamily A member 1	Homo sapiens	25-30
21195050-4	2011	Here we use conventional single channel inside-out and outside-out patch recording from the human TRPA1 channel transiently expressed in human embryonic kidney 293T cells to characterize the selectivity of the channel for inorganic mono-/divalent and organic monovalent cations in the presence of allylisothiocyanate (AITC).	allyl isothiocyanate	297-316	transient receptor potential cation channel subfamily A member 1	Homo sapiens	98-103
21195050-4	2011	Here we use conventional single channel inside-out and outside-out patch recording from the human TRPA1 channel transiently expressed in human embryonic kidney 293T cells to characterize the selectivity of the channel for inorganic mono-/divalent and organic monovalent cations in the presence of allylisothiocyanate (AITC).	allyl isothiocyanate	318-322	transient receptor potential cation channel subfamily A member 1	Homo sapiens	98-103
21266172-3	2011	TRPA1 is activated by low temperature stimuli, mechanosensation and pungent irritants such as AITC and cinnamaldehyde.	allyl isothiocyanate	94-98	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
21051219-7	2011	We have chosen TRPA1 from the TRPA ("ankyrin") family as a model channel which was stimulated by allyl isothiocyanate (AITC).	allyl isothiocyanate	97-117	tryptase gamma 1	Homo sapiens	15-19
21051219-7	2011	We have chosen TRPA1 from the TRPA ("ankyrin") family as a model channel which was stimulated by allyl isothiocyanate (AITC).	allyl isothiocyanate	119-123	transient receptor potential cation channel subfamily A member 1	Homo sapiens	15-20
21051219-7	2011	We have chosen TRPA1 from the TRPA ("ankyrin") family as a model channel which was stimulated by allyl isothiocyanate (AITC).	allyl isothiocyanate	119-123	tryptase gamma 1	Homo sapiens	15-19
20639352-7	2010	2) The same TNFalpha pretreatment also induced similar but less pronounced and less uniform increases in the responses to acid (pH 6.5-5.5), 2-aminoethoxydiphenyl borate (2-APB), a common activator of TRPV1, V2, and V3 channels, and allyl isothiocyanate (AITC), a selective activator of TRPA1 channel.	allyl isothiocyanate	233-253	tumor necrosis factor	Rattus norvegicus	12-20
21076024-3	2011	In decerebrate rats, allyl isothiocyanate, a TRPA1 agonist, was injected intra-arterially into the hindlimb muscle circulation.	allyl isothiocyanate	21-41	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	45-50
21133676-2	2010	However, we found unexpectedly that allyl isothiocyanate (AITC) and structural analogs triggered a membrane potential and calcium dye responses in TRPM5-HEK cells (AITC EC50 = 9.0 +- 2.4 muM, n = 5).	allyl isothiocyanate	36-56	transient receptor potential cation channel subfamily M member 5	Homo sapiens	147-152
21133676-2	2010	However, we found unexpectedly that allyl isothiocyanate (AITC) and structural analogs triggered a membrane potential and calcium dye responses in TRPM5-HEK cells (AITC EC50 = 9.0 +- 2.4 muM, n = 5).	allyl isothiocyanate	36-56	latexin	Homo sapiens	187-190
21133676-2	2010	However, we found unexpectedly that allyl isothiocyanate (AITC) and structural analogs triggered a membrane potential and calcium dye responses in TRPM5-HEK cells (AITC EC50 = 9.0 +- 2.4 muM, n = 5).	allyl isothiocyanate	58-62	transient receptor potential cation channel subfamily M member 5	Homo sapiens	147-152
21133676-2	2010	However, we found unexpectedly that allyl isothiocyanate (AITC) and structural analogs triggered a membrane potential and calcium dye responses in TRPM5-HEK cells (AITC EC50 = 9.0 +- 2.4 muM, n = 5).	allyl isothiocyanate	58-62	latexin	Homo sapiens	187-190
21133676-5	2010	An AITC-evoked current in TRPM5-HEK cells was confirmed in whole-cell voltage clamp recording.	allyl isothiocyanate	3-7	transient receptor potential cation channel subfamily M member 5	Homo sapiens	26-31
20739601-4	2010	AITC and/or capsaicin activated the vast majority of histamine- and PAR-2 agonist-sensitive TG cells.	allyl isothiocyanate	0-4	pulmonary adenoma resistance 2	Mus musculus	68-73
21472349-0	2010	Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C.	allyl isothiocyanate	0-20	cell division cycle 25B	Homo sapiens	115-121
21472349-0	2010	Allyl isothiocyanate induces G2/M arrest in human colorectal adenocarcinoma SW620 cells through down-regulation of Cdc25B and Cdc25C.	allyl isothiocyanate	0-20	cell division cycle 25C	Homo sapiens	126-132
21109004-2	2011	However, little is known regarding the effect of structurally related compounds such as allyl isothiocyanate (AITC), butyl isothiocyanate (BITC) and phenylethyl isothiocyanate (PEITC) on Nrf2 target gene expression.	allyl isothiocyanate	88-108	nuclear factor, erythroid derived 2, like 2	Mus musculus	187-191
20717636-9	2010	The cold-induced contractions of proximal (P<0.01, P<0.05) and distal colons (both P<0.001) were almost abolished or inhibited by the pretreatments of TRPA1 agonists, Allyl isothiocyanate (AITC, 300 mumol/L) and cinnamaldehyde (CA, 1 mmol/L).	allyl isothiocyanate	176-196	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	160-165
20442136-2	2010	METHODS AND RESULTS: TRPA1 agonists allyl isothiocyanate and cinnamaldehyde (CA) significantly increased blood flow in the skin of anaesthetized WT, but not in TRPA1 KO mice.	allyl isothiocyanate	36-56	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	21-26
20717636-9	2010	The cold-induced contractions of proximal (P<0.01, P<0.05) and distal colons (both P<0.001) were almost abolished or inhibited by the pretreatments of TRPA1 agonists, Allyl isothiocyanate (AITC, 300 mumol/L) and cinnamaldehyde (CA, 1 mmol/L).	allyl isothiocyanate	198-202	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	160-165
19888597-8	2010	At subsaturating concentrations, the fenamate NSAIDs also potentiate the activation of TRPA1 by allyl isothiocyanate, cinnamaldehyde, and cold, demonstrating positive synergistic interactions with other well-characterized TRPA1 activators.	allyl isothiocyanate	96-116	transient receptor potential cation channel subfamily A member 1	Homo sapiens	87-92
20590633-1	2010	BACKGROUND AND PURPOSE: Transient receptor potential ankyrin 1 (TRPA1) channels are expressed by primary afferent neurones and activated by irritant chemicals including allyl isothiocyanate (AITC).	allyl isothiocyanate	169-189	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	24-62
20590633-1	2010	BACKGROUND AND PURPOSE: Transient receptor potential ankyrin 1 (TRPA1) channels are expressed by primary afferent neurones and activated by irritant chemicals including allyl isothiocyanate (AITC).	allyl isothiocyanate	169-189	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	64-69
20590633-1	2010	BACKGROUND AND PURPOSE: Transient receptor potential ankyrin 1 (TRPA1) channels are expressed by primary afferent neurones and activated by irritant chemicals including allyl isothiocyanate (AITC).	allyl isothiocyanate	191-195	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	24-62
20590633-1	2010	BACKGROUND AND PURPOSE: Transient receptor potential ankyrin 1 (TRPA1) channels are expressed by primary afferent neurones and activated by irritant chemicals including allyl isothiocyanate (AITC).	allyl isothiocyanate	191-195	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	64-69
20590633-6	2010	Following induction of mild colitis by DSS (2%), spinal c-Fos responses to AITC, but not vehicle, were augmented by 41%.	allyl isothiocyanate	75-79	FBJ osteosarcoma oncogene	Mus musculus	56-61
20219630-1	2010	TRPA1 agonists cinnamaldehyde (CA) and mustard oil (allyl isothiocyanate=AITC) induce heat hyperalgesia and mechanical allodynia in human skin, and sensitize responses of spinal and trigeminal dorsal horn neurons to noxious skin heating in rats.	allyl isothiocyanate	52-72	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
20085483-11	2010	However, Ca(2+) significantly reduced the potency of allyl isothiocyanate (AITC) on TRPA1 but did not affect the potency of carbochol on TRPC6.	allyl isothiocyanate	53-73	transient receptor potential cation channel subfamily A member 1	Homo sapiens	84-89
20085483-11	2010	However, Ca(2+) significantly reduced the potency of allyl isothiocyanate (AITC) on TRPA1 but did not affect the potency of carbochol on TRPC6.	allyl isothiocyanate	75-79	transient receptor potential cation channel subfamily A member 1	Homo sapiens	84-89
20497466-6	2010	Cinnamaldehyde (TRPA1 agonist) elicited a barrage of excitatory postsynaptic currents (EPSCs) in a subset of the SG neurons that responded to allyl isothiocyanate (less specific TRPA1 agonist) and capsaicin (TRPV1 agonist).	allyl isothiocyanate	142-162	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	16-21
20497466-6	2010	Cinnamaldehyde (TRPA1 agonist) elicited a barrage of excitatory postsynaptic currents (EPSCs) in a subset of the SG neurons that responded to allyl isothiocyanate (less specific TRPA1 agonist) and capsaicin (TRPV1 agonist).	allyl isothiocyanate	142-162	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	178-183
19888597-8	2010	At subsaturating concentrations, the fenamate NSAIDs also potentiate the activation of TRPA1 by allyl isothiocyanate, cinnamaldehyde, and cold, demonstrating positive synergistic interactions with other well-characterized TRPA1 activators.	allyl isothiocyanate	96-116	transient receptor potential cation channel subfamily A member 1	Homo sapiens	222-227
19507004-1	2009	Recently, we discovered that transient receptor potential ankyrin1 channel (TRPA1) is highly expressed in human and rat enterochromaffin (EC) cells, and those TRPA1 agonists such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA) enhance the release of serotonin (5-hydroxytryptamine; 5-HT) from EC cells in vitro.	allyl isothiocyanate	182-203	transient receptor potential cation channel subfamily A member 1	Homo sapiens	76-81
20699565-3	2010	ACA was more potent than allyl isothiocyanate, the typical TRPA1 agonist.	allyl isothiocyanate	25-45	transient receptor potential cation channel subfamily A member 1	Homo sapiens	59-64
19845671-5	2009	KEY RESULTS: Inhalation of two selective TRPA1 agonists, allyl isothiocyanate and cinnamaldehyde, dose-dependently caused cough in control guinea pigs, but not in those with airway sensory nerves desensitized by capsaicin.	allyl isothiocyanate	57-77	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	41-46
19507004-1	2009	Recently, we discovered that transient receptor potential ankyrin1 channel (TRPA1) is highly expressed in human and rat enterochromaffin (EC) cells, and those TRPA1 agonists such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA) enhance the release of serotonin (5-hydroxytryptamine; 5-HT) from EC cells in vitro.	allyl isothiocyanate	182-203	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	159-164
19507004-1	2009	Recently, we discovered that transient receptor potential ankyrin1 channel (TRPA1) is highly expressed in human and rat enterochromaffin (EC) cells, and those TRPA1 agonists such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA) enhance the release of serotonin (5-hydroxytryptamine; 5-HT) from EC cells in vitro.	allyl isothiocyanate	205-209	transient receptor potential cation channel subfamily A member 1	Homo sapiens	76-81
19507004-1	2009	Recently, we discovered that transient receptor potential ankyrin1 channel (TRPA1) is highly expressed in human and rat enterochromaffin (EC) cells, and those TRPA1 agonists such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA) enhance the release of serotonin (5-hydroxytryptamine; 5-HT) from EC cells in vitro.	allyl isothiocyanate	205-209	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	159-164
19507004-5	2009	These results indicate that the Ca(2+) influx increase and 5-HT release induced by AITC, CA and acrolein in QGP-1 cells were mediated by TRPA1, and that the QGP-1 cell line could be a new model for the investigation of TRPA1 function in the human EC cell.	allyl isothiocyanate	83-87	transient receptor potential cation channel subfamily A member 1	Homo sapiens	137-142
19545607-1	2009	The TRPA1 agonist mustard oil (allyl isothiocyanate=AITC) induces heat hyperalgesia and mechanical allodynia in human skin and sensitizes rat spinal wide dynamic range (WDR) neuronal responses to noxious skin heating.	allyl isothiocyanate	31-51	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-9
19576208-1	2009	Transient receptor potential ankyrin1 (TRPA1) is a non-selective cation channel activated by cold stimuli under 17 degrees C, mechanosensation, and pungent irritants such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA).	allyl isothiocyanate	174-195	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	0-37
19576208-1	2009	Transient receptor potential ankyrin1 (TRPA1) is a non-selective cation channel activated by cold stimuli under 17 degrees C, mechanosensation, and pungent irritants such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA).	allyl isothiocyanate	174-195	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	39-44
19524560-5	2009	We found that while BDNF treatment primarily increased the fraction of capsaicin-sensitive (TRPV1-expressing) neurons, GDNF exposure led to an increase in the allyl isothiocyanate (AITC)-responding (TRPA1-expressing) population.	allyl isothiocyanate	159-179	glial cell derived neurotrophic factor	Rattus norvegicus	119-123
19524560-5	2009	We found that while BDNF treatment primarily increased the fraction of capsaicin-sensitive (TRPV1-expressing) neurons, GDNF exposure led to an increase in the allyl isothiocyanate (AITC)-responding (TRPA1-expressing) population.	allyl isothiocyanate	181-185	glial cell derived neurotrophic factor	Rattus norvegicus	119-123
19524560-5	2009	We found that while BDNF treatment primarily increased the fraction of capsaicin-sensitive (TRPV1-expressing) neurons, GDNF exposure led to an increase in the allyl isothiocyanate (AITC)-responding (TRPA1-expressing) population.	allyl isothiocyanate	181-185	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	199-204
19524560-6	2009	Moreover, BDNF treatment increased the amplitude of the response to both AITC and capsaicin.	allyl isothiocyanate	73-77	brain-derived neurotrophic factor	Rattus norvegicus	10-14
18671867-3	2008	Acrid, electrophilic chemicals including cinnamaldehyde (CA) and allyl isothiocyanate (AITC), derivatives of cinnamon and mustard oil respectively, activate thermoTRP member TRPA1 via direct modification of channel cysteine residues.	allyl isothiocyanate	65-85	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	174-179
19409911-7	2009	The potencies of activation by the 3 terpenoids were equal and almost 10 times stronger than that of allyl isothiocyanate (AITC), which is known as the most potent TRPA1 agonist among all natural products.	allyl isothiocyanate	101-121	transient receptor potential cation channel subfamily A member 1	Homo sapiens	164-169
19409911-7	2009	The potencies of activation by the 3 terpenoids were equal and almost 10 times stronger than that of allyl isothiocyanate (AITC), which is known as the most potent TRPA1 agonist among all natural products.	allyl isothiocyanate	123-127	transient receptor potential cation channel subfamily A member 1	Homo sapiens	164-169
19033534-11	2009	TRPA1 agonist allyl isothiocyanate (AITC) activates most BK-positive nodose and jugular C fibers.	allyl isothiocyanate	14-34	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	0-5
19033534-11	2009	TRPA1 agonist allyl isothiocyanate (AITC) activates most BK-positive nodose and jugular C fibers.	allyl isothiocyanate	36-40	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	0-5
18814910-2	2009	TRPA1 is activated by either covalent or reversible binding of various chemical compounds, including allylisothiocyanate or acrolein, and is further sensitised by increases in the intracellular Ca(2+) concentration.	allyl isothiocyanate	101-120	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
18954467-5	2008	RESULTS: The in vitro potencies of HC-030031 versus cinnamaldehyde or allyl isothiocyanate (AITC or Mustard oil)-induced TRPA1 activation were 4.9 +/- 0.1 and 7.5 +/- 0.2 microM respectively (IC50).	allyl isothiocyanate	70-90	transient receptor potential cation channel subfamily A member 1	Homo sapiens	121-126
18838811-0	2008	TRPA1 agonists--allyl isothiocyanate and cinnamaldehyde--induce adrenaline secretion.	allyl isothiocyanate	16-36	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
18838811-4	2008	However, the mechanism underlying adrenaline secretion by TRPA1 agonists such as allyl isothiocyanate (AITC) and cinnamaldehyde (CNA), the pungent ingredients in mustard and cinnamon, is not known.	allyl isothiocyanate	81-101	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	58-63
18838811-4	2008	However, the mechanism underlying adrenaline secretion by TRPA1 agonists such as allyl isothiocyanate (AITC) and cinnamaldehyde (CNA), the pungent ingredients in mustard and cinnamon, is not known.	allyl isothiocyanate	103-107	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	58-63
18583045-5	2008	Intrathecal administration of TRPA1 antisense (AS) oligodeoxynucleotide (ODN) reduced the TRPA1 expression in DRG as well as suppressed the colitis-induced hyperalgesia to nociceptive colonic distension and intracolonic allyl isothiocyanate (AITC).	allyl isothiocyanate	220-240	transient receptor potential cation channel subfamily A member 1	Homo sapiens	30-35
18583045-5	2008	Intrathecal administration of TRPA1 antisense (AS) oligodeoxynucleotide (ODN) reduced the TRPA1 expression in DRG as well as suppressed the colitis-induced hyperalgesia to nociceptive colonic distension and intracolonic allyl isothiocyanate (AITC).	allyl isothiocyanate	242-246	transient receptor potential cation channel subfamily A member 1	Homo sapiens	30-35
19576208-1	2009	Transient receptor potential ankyrin1 (TRPA1) is a non-selective cation channel activated by cold stimuli under 17 degrees C, mechanosensation, and pungent irritants such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA).	allyl isothiocyanate	197-201	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	0-37
19576208-1	2009	Transient receptor potential ankyrin1 (TRPA1) is a non-selective cation channel activated by cold stimuli under 17 degrees C, mechanosensation, and pungent irritants such as allyl isothiocyanates (AITC) and cinnamaldehyde (CA).	allyl isothiocyanate	197-201	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	39-44
19576208-6	2009	Like other mammalian orthologues, TRPA1 agonists, including AITC, CA, allicin, and diallyl disulfide, evoked a concentration-dependent increase in intracellular Ca(2+) influx in dog TRPA1-expressing cells.	allyl isothiocyanate	60-64	transient receptor potential cation channel subfamily A member 1	Homo sapiens	34-39
19576208-6	2009	Like other mammalian orthologues, TRPA1 agonists, including AITC, CA, allicin, and diallyl disulfide, evoked a concentration-dependent increase in intracellular Ca(2+) influx in dog TRPA1-expressing cells.	allyl isothiocyanate	60-64	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	182-187
19422860-1	2009	The ankyrin transient receptor potential channel TRPA1 is a sensory neuron-specific channel that is gated by various proalgesic agents such as allyl isothiocyanate (AITC), deep cooling or highly depolarizing voltages.	allyl isothiocyanate	143-163	transient receptor potential cation channel subfamily A member 1	Homo sapiens	49-54
19422860-1	2009	The ankyrin transient receptor potential channel TRPA1 is a sensory neuron-specific channel that is gated by various proalgesic agents such as allyl isothiocyanate (AITC), deep cooling or highly depolarizing voltages.	allyl isothiocyanate	165-169	transient receptor potential cation channel subfamily A member 1	Homo sapiens	49-54
19171673-7	2009	9-OA-NO(2) activated a subset of mouse vagal and trigeminal sensory neurons, which also responded to the TRPA1 agonist allyl isothiocyanate and the TRPV1 agonist capsaicin.	allyl isothiocyanate	119-139	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	105-110
19216492-8	2009	To prove the plausible transformation of ITC from thiol to amine, synthetic AITC-conjugated N(alpha)-acetyl-L-cysteine (NAC) was incubated with BGK at 37 degrees C in physiological buffer, and the generation of AITC-Lys was analyzed.	allyl isothiocyanate	76-80	synuclein alpha	Homo sapiens	120-123
19211797-5	2009	We also found that TRPA1 agonists, including allyl isothiocyanate and cinnamaldehyde, stimulate EC cell functions, such as increasing intracellular Ca(2+) levels and 5-HT release, by using highly concentrated EC cell fractions and a model of EC cell function, the RIN14B cell line.	allyl isothiocyanate	45-65	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	19-24
19378721-5	2009	RESULTS: Only mice treated at adult age became less sensitive to heat stimuli, while both treatment groups lost sensitivity to specific vanilloid agonists of TRPV1 and, interestingly, to allyl-isothiocyanate, a selective agonist of TRPA1.	allyl isothiocyanate	187-207	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	232-237
18671867-3	2008	Acrid, electrophilic chemicals including cinnamaldehyde (CA) and allyl isothiocyanate (AITC), derivatives of cinnamon and mustard oil respectively, activate thermoTRP member TRPA1 via direct modification of channel cysteine residues.	allyl isothiocyanate	87-91	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	174-179
18671867-7	2008	Accordingly, we identified a population of mouse DRG neurons responsive to 15d-PGJ2 and AITC that is absent in cultures derived from TRPA1 knockout mice.	allyl isothiocyanate	88-92	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	133-138
18515013-1	2008	Our recent study has shown that activation of transient receptor potential A1 channel (TRPA1) by pungent chemicals such as allyl-isothiocyanate (AITC) requires an unidentified cytosolic factor whose action can be mimicked by inorganic polyphosphates.	allyl isothiocyanate	123-143	transient receptor potential cation channel subfamily A member 1	Homo sapiens	87-92
18515013-1	2008	Our recent study has shown that activation of transient receptor potential A1 channel (TRPA1) by pungent chemicals such as allyl-isothiocyanate (AITC) requires an unidentified cytosolic factor whose action can be mimicked by inorganic polyphosphates.	allyl isothiocyanate	145-149	transient receptor potential cation channel subfamily A member 1	Homo sapiens	87-92
18272293-2	2008	In the present study, we found that TRPA1 receptor activation with allyl isothiocyanate or cinnamaldehyde caused dose-dependent spontaneous nociception when injected into the mouse hind paw.	allyl isothiocyanate	67-87	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	36-41
18501939-1	2008	The TRPA1 channel is activated by a number of pungent chemicals, such as allylisothiocyanate, present in mustard oil and thiosulfinates present in garlic.	allyl isothiocyanate	73-92	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-9
18495815-4	2008	In inside-out patches from HeLa cells expressing mouse TRPA1, polytriphosphate (PPPi) was added to the bath solution to keep TRPA1 sensitive to allyl isothiocyanate (AITC; mustard oil).	allyl isothiocyanate	166-170	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	125-130
18334983-10	2008	Activation by thymol desensitized hTRPA1 to further exposure to thymol or the known ligand allyl isothiocyanate (AITC).	allyl isothiocyanate	91-111	transient receptor potential cation channel subfamily A member 1	Homo sapiens	34-40
18334983-10	2008	Activation by thymol desensitized hTRPA1 to further exposure to thymol or the known ligand allyl isothiocyanate (AITC).	allyl isothiocyanate	113-117	transient receptor potential cation channel subfamily A member 1	Homo sapiens	34-40
18171730-6	2008	Furthermore, using a quadruple TRPA1 mutant, we show that the mechanism of action of farnesyl thiosalicylic acid differs from that of the reactive electrophilic reagent allylisothiocyanate.	allyl isothiocyanate	169-188	transient receptor potential cation channel subfamily A member 1	Homo sapiens	31-36
18463259-2	2008	Through covalent modification of cysteine and lysine residues, TRPA1 can be activated by electrophilic compounds, including active ingredients of pungent natural products (e.g., allyl isothiocyanate), environmental irritants (e.g., acrolein), and endogenous ligands (4-hydroxynonenal).	allyl isothiocyanate	178-198	transient receptor potential cation channel subfamily A member 1	Homo sapiens	63-68
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	64-84	kininogen 1	Homo sapiens	14-24
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	64-84	transient receptor potential cation channel subfamily A member 1	Homo sapiens	39-44
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	64-84	transient receptor potential cation channel subfamily A member 1	Homo sapiens	137-142
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	64-84	kininogen 1	Homo sapiens	147-157
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	64-84	bradykinin receptor B2	Homo sapiens	170-173
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	86-90	kininogen 1	Homo sapiens	14-24
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	86-90	transient receptor potential cation channel subfamily A member 1	Homo sapiens	39-44
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	86-90	transient receptor potential cation channel subfamily A member 1	Homo sapiens	137-142
18356188-4	2008	We found that bradykinin increased the TRPA1 currents evoked by allyl isothiocyanate (AITC) or cinnamaldehyde in HEK293 cells expressing TRPA1 and bradykinin receptor 2 (B2R).	allyl isothiocyanate	86-90	kininogen 1	Homo sapiens	147-157
18356188-9	2008	Finally, subcutaneous pre-injection of a sub-inflammatory dose of bradykinin into rat hind paw enhanced AITC-induced pain behaviours, which was consistent with the observations in vitro.	allyl isothiocyanate	104-108	kininogen 1	Homo sapiens	66-76
18272293-6	2008	In contrast, the intrathecal treatment with TRPA1 antisense oligodeoxynucleotide (2.5 nmol/site) and the degeneration of the subset of primary afferent fibers sensitive to capsaicin significantly reduced allyl isothiocyanate-induced nociception.	allyl isothiocyanate	204-224	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	44-49
18272293-10	2008	The selective NK(1) receptor antagonist N(2)-[(4R)-4-hydroxy-1-(1-methyl-1H-indol-3-yl) carbony-1-L-prolyl]-N-methyl-N-phenylmethyl-3-2-(2-naphtyl)-L-alaninamide (10 nmol/paw) reduced either capsaicin- or allyl isothiocyanate-induced nociception.	allyl isothiocyanate	205-225	tachykinin receptor 1	Mus musculus	14-28
18272293-11	2008	Collectively, the present findings demonstrate that the TRPA1 agonist allyl isothiocyanate produces a consistent nociceptive response when injected into the mouse paw, an effect that seems to be mediated via activation of TRPA1 receptor and dependent on the capsaicin-sensitive fibers, release of histamine by mast cells and participation of tachykinins.	allyl isothiocyanate	70-90	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	56-61
18272293-11	2008	Collectively, the present findings demonstrate that the TRPA1 agonist allyl isothiocyanate produces a consistent nociceptive response when injected into the mouse paw, an effect that seems to be mediated via activation of TRPA1 receptor and dependent on the capsaicin-sensitive fibers, release of histamine by mast cells and participation of tachykinins.	allyl isothiocyanate	70-90	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	222-227
17567811-1	2007	Pungent chemicals such as allyl isothiocyanate (AITC), cinnamaldehyde, and allicin, produce nociceptive sensation by directly activating transient receptor potential A1 (TRPA1) expressed in sensory afferent neurons.	allyl isothiocyanate	26-46	transient receptor potential cation channel subfamily A member 1	Homo sapiens	137-168
18322093-1	2008	Transient receptor potential A1 (TRPA1) is expressed in a subset of nociceptive sensory neurons where it acts as a sensor for environmental irritants, including acrolein, and some pungent plant ingredients such as allyl isothiocyanate and cinnamaldehyde.	allyl isothiocyanate	214-234	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	33-38
18364033-7	2008	H(2)O(2) caused Ca(2+) influx in a subset of dorsal root ganglia neurons, which responded to allyl isothiocyanate, a TRPA1 ligand.	allyl isothiocyanate	93-113	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	117-122
18279313-6	2008	Single-channel recordings reveal that HTS opens an ion channel that displays similar single-channel conductance to that evoked by the TRPA1 agonist allyl isothiocyanate (AITC) in both recombinant rat TRPA1 cell lines and rat dorsal root ganglia neurons.	allyl isothiocyanate	148-168	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	134-139
18279313-6	2008	Single-channel recordings reveal that HTS opens an ion channel that displays similar single-channel conductance to that evoked by the TRPA1 agonist allyl isothiocyanate (AITC) in both recombinant rat TRPA1 cell lines and rat dorsal root ganglia neurons.	allyl isothiocyanate	148-168	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	200-205
18279313-6	2008	Single-channel recordings reveal that HTS opens an ion channel that displays similar single-channel conductance to that evoked by the TRPA1 agonist allyl isothiocyanate (AITC) in both recombinant rat TRPA1 cell lines and rat dorsal root ganglia neurons.	allyl isothiocyanate	170-174	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	134-139
18279313-6	2008	Single-channel recordings reveal that HTS opens an ion channel that displays similar single-channel conductance to that evoked by the TRPA1 agonist allyl isothiocyanate (AITC) in both recombinant rat TRPA1 cell lines and rat dorsal root ganglia neurons.	allyl isothiocyanate	170-174	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	200-205
17942619-1	2008	Mustard oil [allyl isothiocyanate (AITC)] and cinnamaldehyde (CA), agonists of the ion channel TRPA1 expressed in sensory neurons, elicit a burning sensation and heat hyperalgesia.	allyl isothiocyanate	13-33	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	95-100
17942619-1	2008	Mustard oil [allyl isothiocyanate (AITC)] and cinnamaldehyde (CA), agonists of the ion channel TRPA1 expressed in sensory neurons, elicit a burning sensation and heat hyperalgesia.	allyl isothiocyanate	35-39	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	95-100
18082143-1	2008	TRPA1 channels are non-selective cation channels activated by plant derived pungent products including allyl isothiocyanate (AITC) from mustard.	allyl isothiocyanate	103-123	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
18082143-1	2008	TRPA1 channels are non-selective cation channels activated by plant derived pungent products including allyl isothiocyanate (AITC) from mustard.	allyl isothiocyanate	125-129	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
17825279-6	2007	A TRPA1 agonist allyl isothiocyanate (AITC) dose-dependently induced contractions in the proximal and distal colon, whereas in the jejunum and ileum, even 100 muM AITC caused very little contraction.	allyl isothiocyanate	16-36	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	2-7
17825279-6	2007	A TRPA1 agonist allyl isothiocyanate (AITC) dose-dependently induced contractions in the proximal and distal colon, whereas in the jejunum and ileum, even 100 muM AITC caused very little contraction.	allyl isothiocyanate	38-42	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	2-7
17825279-6	2007	A TRPA1 agonist allyl isothiocyanate (AITC) dose-dependently induced contractions in the proximal and distal colon, whereas in the jejunum and ileum, even 100 muM AITC caused very little contraction.	allyl isothiocyanate	163-167	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	2-7
17683869-11	2007	TRPA1 agonist allyl isothiocyanate (mustard oil) 50-100 microM and TRPV1 agonist capsaicin 1-3 microM had no effect.	allyl isothiocyanate	14-34	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
17588549-4	2007	In a subset of cultured mouse DRG neurons, deep cooling (5-18 degrees C) and allyl isothiocyanate (AITC, agonist of TRPA1) induced increases in intracellular Ca(2+) level.	allyl isothiocyanate	77-97	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	116-121
17588549-6	2007	In TRPA1-expressing HEK293 cells, deep cooling and AITC-induced Ca(2+) responses and whole-cell currents.	allyl isothiocyanate	51-55	transient receptor potential cation channel subfamily A member 1	Homo sapiens	3-8
17567811-1	2007	Pungent chemicals such as allyl isothiocyanate (AITC), cinnamaldehyde, and allicin, produce nociceptive sensation by directly activating transient receptor potential A1 (TRPA1) expressed in sensory afferent neurons.	allyl isothiocyanate	26-46	transient receptor potential cation channel subfamily A member 1	Homo sapiens	170-175
17567811-1	2007	Pungent chemicals such as allyl isothiocyanate (AITC), cinnamaldehyde, and allicin, produce nociceptive sensation by directly activating transient receptor potential A1 (TRPA1) expressed in sensory afferent neurons.	allyl isothiocyanate	48-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	137-168
17567811-1	2007	Pungent chemicals such as allyl isothiocyanate (AITC), cinnamaldehyde, and allicin, produce nociceptive sensation by directly activating transient receptor potential A1 (TRPA1) expressed in sensory afferent neurons.	allyl isothiocyanate	48-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	170-175
17164327-1	2006	Allyl isothiocyanate, the pungent principle of wasabi and other mustard oils, produces pain by activating TRPA1, an excitatory ion channel on sensory nerve endings.	allyl isothiocyanate	0-20	transient receptor potential cation channel subfamily A member 1	Homo sapiens	106-111
17097904-0	2007	Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production.	allyl isothiocyanate	0-20	tumor necrosis factor	Mus musculus	168-177
17097904-0	2007	Allyl isothiocyanate (AITC) and phenyl isothiocyanate (PITC) inhibit tumour-specific angiogenesis by downregulating nitric oxide (NO) and tumour necrosis factor-alpha (TNF-alpha) production.	allyl isothiocyanate	22-26	tumor necrosis factor	Mus musculus	168-177
17285310-5	2007	Here, we show that the TRPA1 is activated by the insecticide and natural toxin allyl isothiocyanate which is known as insecticide.	allyl isothiocyanate	79-99	transient receptor potential cation channel subfamily A member 1	Homo sapiens	23-28
17196622-11	2007	Among the active spice-derived components studied, allyl isothiocyanate, zingerone, and curcumin significantly inhibited the cellular production of proinflammatory mediators such as TNF-alpha and nitric oxide, and significantly inhibited the release of MCP-1 from 3T3-L1 adipocytes.	allyl isothiocyanate	51-71	tumor necrosis factor	Mus musculus	182-191
17196622-11	2007	Among the active spice-derived components studied, allyl isothiocyanate, zingerone, and curcumin significantly inhibited the cellular production of proinflammatory mediators such as TNF-alpha and nitric oxide, and significantly inhibited the release of MCP-1 from 3T3-L1 adipocytes.	allyl isothiocyanate	51-71	chemokine (C-C motif) ligand 2	Mus musculus	253-258
17259732-10	2007	Interleukin-4 production by local lymph nodes was suppressed with allyl isothiocyanate but not with capsaicin.	allyl isothiocyanate	66-86	interleukin 4	Mus musculus	0-13
16565438-0	2006	Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells.	allyl isothiocyanate	0-20	matrix metallopeptidase 2	Homo sapiens	119-148
16725114-2	2006	Here we show that vanilloid receptor (TRPV1) stimulation with capsaicin and activation of TRPA1 with allyl isothiocyanate or cinnamaldehyde cause a graded contraction of the rat urinary bladder in vitro.	allyl isothiocyanate	101-121	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	90-95
16725114-6	2006	The selective TRPV1 receptor antagonist SB 366791 (10 microM) blocks capsaicin-induced contraction, but partially reduces allyl isothiocyanate- or cinnamaldehyde-mediated contraction.	allyl isothiocyanate	122-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
16565438-0	2006	Allyl isothiocyanate and its N-acetylcysteine conjugate suppress metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in SK-Hep 1 human hepatoma cells.	allyl isothiocyanate	0-20	DNL-type zinc finger	Homo sapiens	166-171
16565438-4	2006	Our results demonstrate that AITC and NAC-AITC suppress SK-Hep 1 cell proliferation in a dose-dependent manner; by 25% and 30% for 10 microM AITC and 10 microM NAC-AITC, respectively.	allyl isothiocyanate	29-33	DNL-type zinc finger	Homo sapiens	59-64
16565438-7	2006	Reverse transcriptase polymerase chain reaction revealed dose-dependent decreases in MMP-2/-9 messenger RNA levels in both AITC-treated and NAC-AITC-treated cells.	allyl isothiocyanate	123-127	matrix metallopeptidase 2	Homo sapiens	85-93
16565438-7	2006	Reverse transcriptase polymerase chain reaction revealed dose-dependent decreases in MMP-2/-9 messenger RNA levels in both AITC-treated and NAC-AITC-treated cells.	allyl isothiocyanate	144-148	matrix metallopeptidase 2	Homo sapiens	85-93
15053522-3	2004	In the present study, the ability of six plant-derived isothiocyanates (allyl isothiocyanate, iberverin, erucin, sulforaphane, iberin, and cheirolin) to increase tissue levels of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST) in a variety of rat tissues has been compared.	allyl isothiocyanate	72-92	hematopoietic prostaglandin D synthase	Rattus norvegicus	242-267
16467964-7	2006	Neotrofin (AIT), a cognitive-enhancing and neuroprotective drug, caused a robust increase in HO-1 immunoreactive protein in select neuronal regions and increased the expression of HO-2 transcripts.	allyl isothiocyanate	11-14	heme oxygenase 1	Rattus norvegicus	93-97
16467964-7	2006	Neotrofin (AIT), a cognitive-enhancing and neuroprotective drug, caused a robust increase in HO-1 immunoreactive protein in select neuronal regions and increased the expression of HO-2 transcripts.	allyl isothiocyanate	11-14	heme oxygenase 2	Rattus norvegicus	180-184
16614479-0	2006	Induction of quinone reductase by allylisothiocyanate (AITC) and the N-acetylcysteine conjugate of AITC in Hepa1c1c7 mouse hepatoma cells.	allyl isothiocyanate	34-53	crystallin, zeta	Mus musculus	13-30
16614479-0	2006	Induction of quinone reductase by allylisothiocyanate (AITC) and the N-acetylcysteine conjugate of AITC in Hepa1c1c7 mouse hepatoma cells.	allyl isothiocyanate	55-59	crystallin, zeta	Mus musculus	13-30
15033907-10	2004	Detached AITC-treated cells showed no signs of apoptosis as assessed by morphological features or by Annexin V staining but they did show evidence of disrupted tubulin.	allyl isothiocyanate	9-13	annexin A5	Homo sapiens	101-110
15053522-3	2004	In the present study, the ability of six plant-derived isothiocyanates (allyl isothiocyanate, iberverin, erucin, sulforaphane, iberin, and cheirolin) to increase tissue levels of the phase II detoxification enzymes quinone reductase (QR) and glutathione S-transferase (GST) in a variety of rat tissues has been compared.	allyl isothiocyanate	72-92	hematopoietic prostaglandin D synthase	Rattus norvegicus	269-272
15139523-9	2004	ITCs such as phenethyl isothiocyanate (PEITC), sulforaphane (SUL), allyl isothiocyanate (AITC), and curcumin (CUR) strongly inhibited LPS-induced NF-kappaB-luciferase activations, whereas RES increased activation at lower dose, but inhibited activation at higher dose, and tea flavonoids and procyanidin dimers had little or no effects.	allyl isothiocyanate	67-87	nuclear factor kappa B subunit 1	Homo sapiens	146-155
15139523-9	2004	ITCs such as phenethyl isothiocyanate (PEITC), sulforaphane (SUL), allyl isothiocyanate (AITC), and curcumin (CUR) strongly inhibited LPS-induced NF-kappaB-luciferase activations, whereas RES increased activation at lower dose, but inhibited activation at higher dose, and tea flavonoids and procyanidin dimers had little or no effects.	allyl isothiocyanate	89-93	nuclear factor kappa B subunit 1	Homo sapiens	146-155
12896904-0	2003	Allyl isothiocyanate, a constituent of cruciferous vegetables, inhibits growth of PC-3 human prostate cancer xenografts in vivo.	allyl isothiocyanate	0-20	proprotein convertase subtilisin/kexin type 1	Mus musculus	82-86
15139522-9	2004	Allyl isothiocyanate and (-)-epigallocatechin-3-gallate (EGCG) increased AP-1-luciferase activity dose-dependently up to 50 and 100 microM.	allyl isothiocyanate	0-20	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	73-77
12896904-1	2003	We have shown previously that allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, significantly inhibits survival of PC-3 and LNCaP human prostate cancer cells in culture, whereas proliferation of a normal prostate epithelial cell line is minimally affected by AITC even at concentrations that are highly cytotoxic to the prostate cancer cells.	allyl isothiocyanate	30-50	proprotein convertase subtilisin/kexin type 1	Homo sapiens	135-139
12896904-1	2003	We have shown previously that allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, significantly inhibits survival of PC-3 and LNCaP human prostate cancer cells in culture, whereas proliferation of a normal prostate epithelial cell line is minimally affected by AITC even at concentrations that are highly cytotoxic to the prostate cancer cells.	allyl isothiocyanate	52-56	proprotein convertase subtilisin/kexin type 1	Homo sapiens	135-139
12896904-4	2003	injection of 10 micromol AITC, three times per week (Monday, Wednesday and Friday) beginning the day of tumor cell implantation, significantly inhibited the growth of PC-3 xenograft (P < 0.05 by two-way ANOVA).	allyl isothiocyanate	25-29	proprotein convertase subtilisin/kexin type 1	Mus musculus	167-171
12896904-7	2003	Western blot analysis indicated an approximately 70% reduction in the levels of anti-apoptotic protein Bcl-2 in the tumor lysate of AITC-treated mice compared with that of control mice.	allyl isothiocyanate	132-136	B cell leukemia/lymphoma 2	Mus musculus	103-108
12896904-10	2003	In conclusion, the results of the present study indicate that AITC administration inhibits growth of PC-3 xenografts in vivo by inducing apoptosis and reducing mitotic activity.	allyl isothiocyanate	62-66	proprotein convertase subtilisin/kexin type 1	Mus musculus	101-105
34695536-5	2021	Using the TRPA1 agonist allyl isothiocyanate (AITC) as noxious stimulus, we quantified the aversive response and the perceived pain intensity by evaluating explorative running and the mouse grimace scale, respectively.	allyl isothiocyanate	24-44	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	10-15
12771033-2	2003	In the present study, we demonstrate that allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, significantly inhibits proliferation of cultured PC-3 (androgen-independent) and LNCaP (androgen-dependent) human prostate cancer cells in a dose-dependent manner with an IC(50) of approximately 15-17 micro M. On the other hand, survival of a normal prostate epithelial cell line (PrEC) was minimally affected by AITC even at concentrations that were highly cytotoxic to the prostate cancer cells.	allyl isothiocyanate	42-62	proprotein convertase subtilisin/kexin type 1	Homo sapiens	161-165
12771033-2	2003	In the present study, we demonstrate that allyl isothiocyanate (AITC), a constituent of cruciferous vegetables, significantly inhibits proliferation of cultured PC-3 (androgen-independent) and LNCaP (androgen-dependent) human prostate cancer cells in a dose-dependent manner with an IC(50) of approximately 15-17 micro M. On the other hand, survival of a normal prostate epithelial cell line (PrEC) was minimally affected by AITC even at concentrations that were highly cytotoxic to the prostate cancer cells.	allyl isothiocyanate	64-68	proprotein convertase subtilisin/kexin type 1	Homo sapiens	161-165
10825467-1	2000	The dietary isothiocyanates and cancer chemopreventive agents phenethyl isothiocyanate and allyl isothiocyanate and their cysteine conjugates inhibited the growth and induced apoptosis of human leukaemia HL60 (p53-) and human myeloblastic leukaemia-1 cells (p53+) in vitro.	allyl isothiocyanate	91-111	tumor protein p53	Homo sapiens	210-213
10825467-1	2000	The dietary isothiocyanates and cancer chemopreventive agents phenethyl isothiocyanate and allyl isothiocyanate and their cysteine conjugates inhibited the growth and induced apoptosis of human leukaemia HL60 (p53-) and human myeloblastic leukaemia-1 cells (p53+) in vitro.	allyl isothiocyanate	91-111	tumor protein p53	Homo sapiens	258-261
2341092-0	1990	Glutathione S-transferase subunit induction patterns of Brussels sprouts, allyl isothiocyanate and goitrin in rat liver and small intestinal mucosa: a new approach for the identification of inducing xenobiotics.	allyl isothiocyanate	74-94	hematopoietic prostaglandin D synthase	Rattus norvegicus	0-25
2341092-7	1990	The most pronounced difference between the glutathione S-transferase subunit induction patterns due to administration of allyl isothiocyanate and goitrin is the much stronger enhancement of subunit 2 by allyl isothiocyanate.	allyl isothiocyanate	121-141	hematopoietic prostaglandin D synthase	Rattus norvegicus	43-68
2341092-7	1990	The most pronounced difference between the glutathione S-transferase subunit induction patterns due to administration of allyl isothiocyanate and goitrin is the much stronger enhancement of subunit 2 by allyl isothiocyanate.	allyl isothiocyanate	203-223	hematopoietic prostaglandin D synthase	Rattus norvegicus	43-68
12672641-3	2002	High dose levels of AITC, given daily for 5 days, increased the activity of QR and/or GST in the liver, kidneys, lungs, spleen, urinary bladder, glandular and nonglandular stomach, duodenum, jejunum, ileum, cecum, and colon plus rectum of the animals.	allyl isothiocyanate	20-24	hematopoietic prostaglandin D synthase	Rattus norvegicus	86-89
34823152-10	2022	However, the same procedure induced hypersensitivity to mechanical stimulation and the TRPA1 agonist allyl isothiocyanate in the oral mucosa.	allyl isothiocyanate	101-121	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	87-92
34973335-8	2022	Our findings may not only help explain the molecular mechanism underlying the dermatitis and pruritus caused by chemicals like DNFB and DNCB, but also provide a molecular tool 7.5-fold more potent than the current TRPA1 activator allyl isothiocyanate (AITC) used for investigating TRPA1 channel pharmacology and pathology.	allyl isothiocyanate	230-250	transient receptor potential cation channel subfamily A member 1	Homo sapiens	214-219
34973335-8	2022	Our findings may not only help explain the molecular mechanism underlying the dermatitis and pruritus caused by chemicals like DNFB and DNCB, but also provide a molecular tool 7.5-fold more potent than the current TRPA1 activator allyl isothiocyanate (AITC) used for investigating TRPA1 channel pharmacology and pathology.	allyl isothiocyanate	230-250	transient receptor potential cation channel subfamily A member 1	Homo sapiens	281-286
34973335-8	2022	Our findings may not only help explain the molecular mechanism underlying the dermatitis and pruritus caused by chemicals like DNFB and DNCB, but also provide a molecular tool 7.5-fold more potent than the current TRPA1 activator allyl isothiocyanate (AITC) used for investigating TRPA1 channel pharmacology and pathology.	allyl isothiocyanate	252-256	transient receptor potential cation channel subfamily A member 1	Homo sapiens	214-219
34973335-8	2022	Our findings may not only help explain the molecular mechanism underlying the dermatitis and pruritus caused by chemicals like DNFB and DNCB, but also provide a molecular tool 7.5-fold more potent than the current TRPA1 activator allyl isothiocyanate (AITC) used for investigating TRPA1 channel pharmacology and pathology.	allyl isothiocyanate	252-256	transient receptor potential cation channel subfamily A member 1	Homo sapiens	281-286
34695536-5	2021	Using the TRPA1 agonist allyl isothiocyanate (AITC) as noxious stimulus, we quantified the aversive response and the perceived pain intensity by evaluating explorative running and the mouse grimace scale, respectively.	allyl isothiocyanate	46-50	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	10-15
34887468-5	2021	Companilactobacillus farciminis KB1089 was selected as a lactic acid bacteria strain model that metabolizes sinigrin, which is a GSL, into allylisothiocyanate.	allyl isothiocyanate	139-158	cathepsin A	Homo sapiens	129-132
35236901-3	2022	Topical application of a TRPA1 agonist, allyl isothiocyanate (AITC), dose-dependently triggered swallowing reflexes.	allyl isothiocyanate	40-60	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	25-30
34955831-7	2021	In addition, histological and western blot data showed that Nav1.7 expressions in the TGs were significantly higher in the AITC group than in the naive and saline group rats.	allyl isothiocyanate	123-127	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	60-66
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	BCL2 associated X, apoptosis regulator	Rattus norvegicus	29-32
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	caspase 3	Rattus norvegicus	34-43
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	heme oxygenase 1	Rattus norvegicus	45-49
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	growth associated protein 43	Rattus norvegicus	51-56
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	vascular endothelial growth factor A	Rattus norvegicus	62-66
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	interleukin 1 alpha	Rattus norvegicus	85-93
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	interleukin 6	Rattus norvegicus	95-99
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	BCL2, apoptosis regulator	Rattus norvegicus	112-117
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	glial fibrillary acidic protein	Rattus norvegicus	119-123
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	125-130
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	activating transcription factor 4	Rattus norvegicus	143-147
34493133-8	2021	AITC increased the levels of Bax, caspase-3, HO-1, GAP43, and VEGF, while decreasing IL-1beta, IL-6, NF-kappaB, Bcl-2, GFAP, Grp78, activating ATF4 and ATF6 as compared to the LED group (p <0.05).	allyl isothiocyanate	0-4	activating transcription factor 6	Rattus norvegicus	152-156
34802946-0	2021	Effects of allyl isothiocyanate on the expression, function, and its mechanism of ABCA1 and ABCG1 in pulmonary of COPD rats.	allyl isothiocyanate	11-31	ATP binding cassette subfamily A member 1	Rattus norvegicus	82-87
34802946-0	2021	Effects of allyl isothiocyanate on the expression, function, and its mechanism of ABCA1 and ABCG1 in pulmonary of COPD rats.	allyl isothiocyanate	11-31	ATP binding cassette subfamily G member 1	Rattus norvegicus	92-97
34912298-7	2021	TRPA1 channels are activated by compounds such as cinnamaldehyde, allyl isothiocyanate, allicin and methyl syringate, which are present naturally in food items such as cinnamon, wasabi, mustard, garlic, etc.	allyl isothiocyanate	66-86	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
34635025-13	2022	Furthermore, the inflammatory cytokine, TNF-alpha, was reduced upon administration of AITC with DOX.	allyl isothiocyanate	86-90	tumor necrosis factor	Rattus norvegicus	40-49
34635025-14	2022	The cardio-protection of AITC is attributed to increase the expression of cytoprotective nuclear factor erythroid 2-related factor 2 (Nrf2).	allyl isothiocyanate	25-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	89-132
34635025-14	2022	The cardio-protection of AITC is attributed to increase the expression of cytoprotective nuclear factor erythroid 2-related factor 2 (Nrf2).	allyl isothiocyanate	25-29	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
34248678-2	2021	Experiments were undertaken to examine the mechanisms underlying effects of TRPA1 (allyl isothiocyanate, AITC), TRPV1 (capsaicin, CAPS), and TRPC (oleoyl-2-acetyl-sn-glycerol, OAG) agonists on guinea pig bladder activity.	allyl isothiocyanate	83-103	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	76-81
34802532-7	2021	Molecular docking results indicated that ASN511 at the cox1 subunit was the binding site of AITC by one hydrogen bond, with a bond distance of 2.1 A.	allyl isothiocyanate	92-96	COX1	Sitophilus zeamais	55-59
34475054-9	2021	AITC increased p-ATMSer1981, p-ATRSer428, p53, p-p53Ser15, p-H2A.XSer139, BRCA1, and PARP at 10-30 muM at 24 and 48 h treatments.	allyl isothiocyanate	0-4	tumor protein p53	Homo sapiens	42-45
34475054-9	2021	AITC increased p-ATMSer1981, p-ATRSer428, p53, p-p53Ser15, p-H2A.XSer139, BRCA1, and PARP at 10-30 muM at 24 and 48 h treatments.	allyl isothiocyanate	0-4	tumor protein p53	Homo sapiens	49-52
34475054-9	2021	AITC increased p-ATMSer1981, p-ATRSer428, p53, p-p53Ser15, p-H2A.XSer139, BRCA1, and PARP at 10-30 muM at 24 and 48 h treatments.	allyl isothiocyanate	0-4	BRCA1 DNA repair associated	Homo sapiens	74-79
34475054-9	2021	AITC increased p-ATMSer1981, p-ATRSer428, p53, p-p53Ser15, p-H2A.XSer139, BRCA1, and PARP at 10-30 muM at 24 and 48 h treatments.	allyl isothiocyanate	0-4	poly(ADP-ribose) polymerase 1	Homo sapiens	85-89
34475054-10	2021	However, AITC decreased DNA-PK at 24 and 48 h treatment, and decreased MGMT at 48 h in MCF-7 cells.	allyl isothiocyanate	9-13	O-6-methylguanine-DNA methyltransferase	Homo sapiens	71-75
34271065-10	2021	Compared with other known TRPA1 agonists, including allyl isothiocyanate (AITC), cinnamaldehyde, crotonaldehyde, and formaldehyde, acrolein stimulated a more potent TRPA1-dependent relaxation.	allyl isothiocyanate	52-72	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	26-31
34271065-10	2021	Compared with other known TRPA1 agonists, including allyl isothiocyanate (AITC), cinnamaldehyde, crotonaldehyde, and formaldehyde, acrolein stimulated a more potent TRPA1-dependent relaxation.	allyl isothiocyanate	74-78	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	26-31
35626730-4	2022	Mice lacking Slack globally (Slack-/-) or conditionally in sensory neurons (SNS-Slack-/-) demonstrated increased pain behavior after intraplantar injection of the TRPA1 activator allyl isothiocyanate.	allyl isothiocyanate	179-199	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	163-168
35176939-8	2022	AITC prominently balanced the inflammatory status and oxidative stress by lowering key proinflammatory mediators (NF-kappaB, TNF-alpha, IL-1beta, IL-6, and IL-8) and increasing the activities of antioxidant enzymes (SOD, GSH-Px).	allyl isothiocyanate	0-4	tumor necrosis factor	Rattus norvegicus	125-134
35176939-8	2022	AITC prominently balanced the inflammatory status and oxidative stress by lowering key proinflammatory mediators (NF-kappaB, TNF-alpha, IL-1beta, IL-6, and IL-8) and increasing the activities of antioxidant enzymes (SOD, GSH-Px).	allyl isothiocyanate	0-4	interleukin 1 alpha	Rattus norvegicus	136-144
35176939-8	2022	AITC prominently balanced the inflammatory status and oxidative stress by lowering key proinflammatory mediators (NF-kappaB, TNF-alpha, IL-1beta, IL-6, and IL-8) and increasing the activities of antioxidant enzymes (SOD, GSH-Px).	allyl isothiocyanate	0-4	interleukin 6	Rattus norvegicus	146-150
35176939-9	2022	Also, levels of protective tear proteins, including Muc1, Muc4, and Muc5 were recovered with AITC supplementation.	allyl isothiocyanate	93-97	mucin 1, cell surface associated	Rattus norvegicus	52-56
35176939-9	2022	Also, levels of protective tear proteins, including Muc1, Muc4, and Muc5 were recovered with AITC supplementation.	allyl isothiocyanate	93-97	mucin 4, cell surface associated	Rattus norvegicus	58-62
35236901-3	2022	Topical application of a TRPA1 agonist, allyl isothiocyanate (AITC), dose-dependently triggered swallowing reflexes.	allyl isothiocyanate	62-66	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	25-30
35236901-4	2022	Prior topical application of a TRPA1 antagonist significantly attenuated the AITC-induced reflexes.	allyl isothiocyanate	77-81	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	31-36
35163843-6	2022	Radioactive 45Ca2+ uptake and ATP-based luminescence indicating cell viability were measured in PE/CA-PJ41 cells in response to the TRPA1 agonist allyl-isothiocyanate (AITC) and TRPV1 agonist capsaicin to determine receptor function.	allyl isothiocyanate	146-166	transient receptor potential cation channel subfamily A member 1	Homo sapiens	132-137
35163843-6	2022	Radioactive 45Ca2+ uptake and ATP-based luminescence indicating cell viability were measured in PE/CA-PJ41 cells in response to the TRPA1 agonist allyl-isothiocyanate (AITC) and TRPV1 agonist capsaicin to determine receptor function.	allyl isothiocyanate	168-172	transient receptor potential cation channel subfamily A member 1	Homo sapiens	132-137
35163843-6	2022	Radioactive 45Ca2+ uptake and ATP-based luminescence indicating cell viability were measured in PE/CA-PJ41 cells in response to the TRPA1 agonist allyl-isothiocyanate (AITC) and TRPV1 agonist capsaicin to determine receptor function.	allyl isothiocyanate	168-172	transient receptor potential cation channel subfamily V member 1	Homo sapiens	178-183
35096424-4	2022	We found that, at a concentration as low as one-tenth that of allyl isothiocyanate, sulforaphane reduced triacylglycerol levels, lipid-filled adipocyte quantity, and mRNA and protein levels of CCAAT-enhancer-binding protein alpha (C/EBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma).	allyl isothiocyanate	62-82	CCAAT enhancer binding protein alpha	Homo sapiens	193-229
35163843-8	2022	TRPA1 and TRPV1 activation (100 microM AITC, 100 nM capsaicin) induced 45Ca2+-influx into PE/CA-PJ41 cells.	allyl isothiocyanate	39-43	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
35163843-8	2022	TRPA1 and TRPV1 activation (100 microM AITC, 100 nM capsaicin) induced 45Ca2+-influx into PE/CA-PJ41 cells.	allyl isothiocyanate	39-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	10-15
33479347-6	2021	The channel activity in Panc-1 cells, as assessed with electrophysiological (whole-cell patch clamp) and microfluorimetry methods, showed that non-selective cationic currents were activated by allyl isothiocyanate (AITC) in Panc-1 cells and inhibited by the selective TRPA1 antagonist A-967079.	allyl isothiocyanate	193-213	transient receptor potential cation channel subfamily A member 1	Homo sapiens	268-273
33957206-9	2021	Zoniporide and allyl isothiocyanate (AITC, TRPA1 agonist) increased calcium transients in the same DRG neuron, whereas that A-967079 (TRPA1 antagonist) prevented the effect of zoniporide in DRG neurons.	allyl isothiocyanate	15-35	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	43-48
33957206-10	2021	Repeated AITC induced TRPA1 desensitization and this effect was prevented by zoniporide.	allyl isothiocyanate	9-13	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	22-27
34058071-18	2021	The inhibitory effect of GDC-0334 on dermal blood flow induced by the TRPA1 agonist allyl isothiocyanate in humans indicates a clear PK-PD relationship.	allyl isothiocyanate	84-104	transient receptor potential cation channel subfamily A member 1	Homo sapiens	70-75
33968075-4	2021	A differential response in calcium mobilization upon AITC treatment in leucocytes from healthy humans confirmed a relevance of TAS2R38 functionality, independent from cation channel TRPV1 or TRPA1 activation.	allyl isothiocyanate	53-57	taste 2 receptor member 38	Homo sapiens	127-134
33579280-0	2021	AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.	allyl isothiocyanate	0-4	transient receptor potential cation channel subfamily A member 1	Homo sapiens	54-59
33579280-0	2021	AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.	allyl isothiocyanate	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	81-85
33579280-0	2021	AITC inhibits fibroblast-myofibroblast transition via TRPA1-independent MAPK and NRF2/HO-1 pathways and reverses corticosteroids insensitivity in human lung fibroblasts.	allyl isothiocyanate	0-4	heme oxygenase 1	Homo sapiens	86-90
33579280-6	2021	Post-treatment of TRPA1 activator, allyl isothiocyanate (AITC), after TGF-beta1 significantly downregulated the alpha-SMA gene induction (P < 0.01 at 24 h), protein expression (P < 0.05) and immunoreactivity with stress fibers (P < 0.05).	allyl isothiocyanate	35-55	transient receptor potential cation channel subfamily A member 1	Homo sapiens	18-23
33579280-6	2021	Post-treatment of TRPA1 activator, allyl isothiocyanate (AITC), after TGF-beta1 significantly downregulated the alpha-SMA gene induction (P < 0.01 at 24 h), protein expression (P < 0.05) and immunoreactivity with stress fibers (P < 0.05).	allyl isothiocyanate	35-55	transforming growth factor beta 1	Homo sapiens	70-79
33579280-6	2021	Post-treatment of TRPA1 activator, allyl isothiocyanate (AITC), after TGF-beta1 significantly downregulated the alpha-SMA gene induction (P < 0.01 at 24 h), protein expression (P < 0.05) and immunoreactivity with stress fibers (P < 0.05).	allyl isothiocyanate	35-55	actin alpha 1, skeletal muscle	Homo sapiens	112-121
33579280-6	2021	Post-treatment of TRPA1 activator, allyl isothiocyanate (AITC), after TGF-beta1 significantly downregulated the alpha-SMA gene induction (P < 0.01 at 24 h), protein expression (P < 0.05) and immunoreactivity with stress fibers (P < 0.05).	allyl isothiocyanate	57-61	transient receptor potential cation channel subfamily A member 1	Homo sapiens	18-23
33579280-6	2021	Post-treatment of TRPA1 activator, allyl isothiocyanate (AITC), after TGF-beta1 significantly downregulated the alpha-SMA gene induction (P < 0.01 at 24 h), protein expression (P < 0.05) and immunoreactivity with stress fibers (P < 0.05).	allyl isothiocyanate	57-61	transforming growth factor beta 1	Homo sapiens	70-79
33579280-6	2021	Post-treatment of TRPA1 activator, allyl isothiocyanate (AITC), after TGF-beta1 significantly downregulated the alpha-SMA gene induction (P < 0.01 at 24 h), protein expression (P < 0.05) and immunoreactivity with stress fibers (P < 0.05).	allyl isothiocyanate	57-61	actin alpha 1, skeletal muscle	Homo sapiens	112-121
33579280-8	2021	AITC significantly increased phosphorylated- extracellular signal-regulated kinase (ERK) 1/2 and heme oxygenase (HO)-1 protein expressions (P < 0.05) in TGF-beta1-treated cells.	allyl isothiocyanate	0-4	mitogen-activated protein kinase 3	Homo sapiens	45-92
33579280-8	2021	AITC significantly increased phosphorylated- extracellular signal-regulated kinase (ERK) 1/2 and heme oxygenase (HO)-1 protein expressions (P < 0.05) in TGF-beta1-treated cells.	allyl isothiocyanate	0-4	heme oxygenase 1	Homo sapiens	97-118
33579280-8	2021	AITC significantly increased phosphorylated- extracellular signal-regulated kinase (ERK) 1/2 and heme oxygenase (HO)-1 protein expressions (P < 0.05) in TGF-beta1-treated cells.	allyl isothiocyanate	0-4	transforming growth factor beta 1	Homo sapiens	153-162
33579280-9	2021	Combined inhibition with ERK1/2 mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor (NRF2) almost completely reversed AITC-induced alpha-SMA suppression (P < 0.05).	allyl isothiocyanate	152-156	mitogen-activated protein kinase 3	Homo sapiens	25-31
33579280-9	2021	Combined inhibition with ERK1/2 mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor (NRF2) almost completely reversed AITC-induced alpha-SMA suppression (P < 0.05).	allyl isothiocyanate	152-156	NFE2 like bZIP transcription factor 2	Homo sapiens	76-117
33579280-9	2021	Combined inhibition with ERK1/2 mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor (NRF2) almost completely reversed AITC-induced alpha-SMA suppression (P < 0.05).	allyl isothiocyanate	152-156	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
33579280-9	2021	Combined inhibition with ERK1/2 mitogen-activated protein kinase (MAPK) and nuclear factor erythroid 2-related factor (NRF2) almost completely reversed AITC-induced alpha-SMA suppression (P < 0.05).	allyl isothiocyanate	152-156	actin alpha 1, skeletal muscle	Homo sapiens	165-174
33579280-12	2021	CONCLUSION: We found that AITC exerts protective effect on TGF-beta1-induced alpha-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts.	allyl isothiocyanate	26-30	transforming growth factor beta 1	Homo sapiens	59-68
33579280-12	2021	CONCLUSION: We found that AITC exerts protective effect on TGF-beta1-induced alpha-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts.	allyl isothiocyanate	26-30	actin alpha 1, skeletal muscle	Homo sapiens	77-86
33579280-12	2021	CONCLUSION: We found that AITC exerts protective effect on TGF-beta1-induced alpha-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts.	allyl isothiocyanate	26-30	mitogen-activated protein kinase 3	Homo sapiens	111-117
33579280-12	2021	CONCLUSION: We found that AITC exerts protective effect on TGF-beta1-induced alpha-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts.	allyl isothiocyanate	26-30	NFE2 like bZIP transcription factor 2	Homo sapiens	127-131
33579280-12	2021	CONCLUSION: We found that AITC exerts protective effect on TGF-beta1-induced alpha-SMA induction by activating ERK1/2 MAPK and NRF2/HO-1 pathways in lung fibroblasts.	allyl isothiocyanate	26-30	heme oxygenase 1	Homo sapiens	132-136
2556881-4	1989	The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 microgram/ml allyl isothiocyanate (AITC) or 0.1 microgram/ml benzyl isothiocyanate (BITC).	allyl isothiocyanate	99-119	glutathione S-transferase pi 1	Rattus norvegicus	18-23
2556881-4	1989	The expression of GST-P was increased with addition of dibutyryl cAMP together with 1 microgram/ml allyl isothiocyanate (AITC) or 0.1 microgram/ml benzyl isothiocyanate (BITC).	allyl isothiocyanate	121-125	glutathione S-transferase pi 1	Rattus norvegicus	18-23
6669172-0	1983	[Effect of allyl isothiocyanate on cytochrome P-450 of rat liver microsomes].	allyl isothiocyanate	11-31	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	35-51
6669172-1	1983	The thrice-repeated oral administration of graded doses (50, 100 and 150 mg/kg of body mass) of allyl mustard oil to rats resulted in a decrease of the cytochrome P-450 and cytochrome b5 contents of the liver microsomes.	allyl isothiocyanate	96-113	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	152-168
6669172-1	1983	The thrice-repeated oral administration of graded doses (50, 100 and 150 mg/kg of body mass) of allyl mustard oil to rats resulted in a decrease of the cytochrome P-450 and cytochrome b5 contents of the liver microsomes.	allyl isothiocyanate	96-113	cytochrome b5 type A	Rattus norvegicus	173-186
33968075-0	2021	Allyl Isothiocyanate: A TAS2R38 Receptor-Dependent Immune Modulator at the Interface Between Personalized Medicine and Nutrition.	allyl isothiocyanate	0-20	taste 2 receptor member 38	Homo sapiens	24-31
33968075-3	2021	We here analyzed the relevance of the TAS2R38 receptor in the regulation of the human immune response using the TAS2R38 agonist allyl isothiocyanate (AITC) from Brassica plants.	allyl isothiocyanate	128-148	taste 2 receptor member 38	Homo sapiens	38-45
33968075-3	2021	We here analyzed the relevance of the TAS2R38 receptor in the regulation of the human immune response using the TAS2R38 agonist allyl isothiocyanate (AITC) from Brassica plants.	allyl isothiocyanate	150-154	taste 2 receptor member 38	Homo sapiens	38-45
33692840-0	2021	Allyl isothiocyanate increases MRP1 expression in cigarette smoke extract-stimulated human bronchial epithelial cells via the JNK/Nrf2 pathway.	allyl isothiocyanate	0-20	ATP binding cassette subfamily C member 1	Homo sapiens	31-35
33692840-0	2021	Allyl isothiocyanate increases MRP1 expression in cigarette smoke extract-stimulated human bronchial epithelial cells via the JNK/Nrf2 pathway.	allyl isothiocyanate	0-20	mitogen-activated protein kinase 8	Homo sapiens	126-129
33692840-0	2021	Allyl isothiocyanate increases MRP1 expression in cigarette smoke extract-stimulated human bronchial epithelial cells via the JNK/Nrf2 pathway.	allyl isothiocyanate	0-20	NFE2 like bZIP transcription factor 2	Homo sapiens	130-134
33692840-5	2021	On this basis, the mechanism of Allyl isothiocyanate (AITC) administration on the expression of MRP1 in CSE-stimulated 16HBE14o-cells was investigated.	allyl isothiocyanate	32-52	ATP binding cassette subfamily C member 1	Homo sapiens	96-100
33692840-5	2021	On this basis, the mechanism of Allyl isothiocyanate (AITC) administration on the expression of MRP1 in CSE-stimulated 16HBE14o-cells was investigated.	allyl isothiocyanate	54-58	ATP binding cassette subfamily C member 1	Homo sapiens	96-100
33692840-10	2021	AITC activated the JNK pathway, inhibited the activation of the p38MAPK pathway in 16HBE14o-cells stimulated by 5% CSE and upregulated the expression levels of Nrf2 and MRP1 in a time-dependent manner.	allyl isothiocyanate	0-4	mitogen-activated protein kinase 8	Homo sapiens	19-22
33692840-10	2021	AITC activated the JNK pathway, inhibited the activation of the p38MAPK pathway in 16HBE14o-cells stimulated by 5% CSE and upregulated the expression levels of Nrf2 and MRP1 in a time-dependent manner.	allyl isothiocyanate	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	160-164
33692840-10	2021	AITC activated the JNK pathway, inhibited the activation of the p38MAPK pathway in 16HBE14o-cells stimulated by 5% CSE and upregulated the expression levels of Nrf2 and MRP1 in a time-dependent manner.	allyl isothiocyanate	0-4	ATP binding cassette subfamily C member 1	Homo sapiens	169-173
33692840-12	2021	Furthermore, the fluorescence intensity in the nucleus was significantly enhanced following AITC pretreatment and the analysis indicated nuclear translocation of Nrf2 in the cells.	allyl isothiocyanate	92-96	NFE2 like bZIP transcription factor 2	Homo sapiens	162-166
33692840-13	2021	These results indicated that Nrf2 and MRP1 expression levels in CSE-stimulated cells were altered following AITC pretreatment.	allyl isothiocyanate	108-112	NFE2 like bZIP transcription factor 2	Homo sapiens	29-33
33692840-13	2021	These results indicated that Nrf2 and MRP1 expression levels in CSE-stimulated cells were altered following AITC pretreatment.	allyl isothiocyanate	108-112	ATP binding cassette subfamily C member 1	Homo sapiens	38-42
33713225-2	2021	To activate the TRPA1 ion channel localized in the skin, its agonist allyl isothiocyanate (AITC) was used in different concentrations (0.04, 0.4, 1, and 2.5%).	allyl isothiocyanate	69-89	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	16-21
33713225-2	2021	To activate the TRPA1 ion channel localized in the skin, its agonist allyl isothiocyanate (AITC) was used in different concentrations (0.04, 0.4, 1, and 2.5%).	allyl isothiocyanate	91-95	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	16-21
33479347-6	2021	The channel activity in Panc-1 cells, as assessed with electrophysiological (whole-cell patch clamp) and microfluorimetry methods, showed that non-selective cationic currents were activated by allyl isothiocyanate (AITC) in Panc-1 cells and inhibited by the selective TRPA1 antagonist A-967079.	allyl isothiocyanate	215-219	transient receptor potential cation channel subfamily A member 1	Homo sapiens	268-273
33272574-5	2021	Plantar injection of sanguinarine evokes nociceptive behaviors similar to that elicited by allyl isothiocyanate (AITC), a classic agonist of TRPA1.	allyl isothiocyanate	91-111	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	141-146
33272574-5	2021	Plantar injection of sanguinarine evokes nociceptive behaviors similar to that elicited by allyl isothiocyanate (AITC), a classic agonist of TRPA1.	allyl isothiocyanate	113-117	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	141-146
32415670-0	2021	Development of AITC-induced dermal blood flow as a translational in vivo biomarker of TRPA1 activity in human and rodent skin.	allyl isothiocyanate	15-19	transient receptor potential cation channel subfamily A member 1	Homo sapiens	86-91
32415670-7	2021	KEY RESULTS: AITC- and citric acid- induced DBF were significantly reduced in Trpa1 KO rats compared to wildtype (90+- 2% and 65+- 11% reduction, respectively), whereas capsaicin response did not differ.	allyl isothiocyanate	13-17	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	78-83
32624316-6	2021	RESULTS: AITC decreased CAR cell viability, induced cell death of CAR cells and inhibited the confluences of cultured CAR cells.	allyl isothiocyanate	9-13	CXADR pseudogene 1	Homo sapiens	24-27
32624316-6	2021	RESULTS: AITC decreased CAR cell viability, induced cell death of CAR cells and inhibited the confluences of cultured CAR cells.	allyl isothiocyanate	9-13	CXADR pseudogene 1	Homo sapiens	66-69
32624316-6	2021	RESULTS: AITC decreased CAR cell viability, induced cell death of CAR cells and inhibited the confluences of cultured CAR cells.	allyl isothiocyanate	9-13	CXADR pseudogene 1	Homo sapiens	66-69
32624316-7	2021	When CAR cells were treated with AITC, activation of caspase-3 and caspase-9 by AITC was observed and could be reversed by Z-VAD-fmk (pan-caspase inhibitor).	allyl isothiocyanate	33-37	CXADR pseudogene 1	Homo sapiens	5-8
32624316-7	2021	When CAR cells were treated with AITC, activation of caspase-3 and caspase-9 by AITC was observed and could be reversed by Z-VAD-fmk (pan-caspase inhibitor).	allyl isothiocyanate	33-37	caspase 3	Homo sapiens	53-62
32624316-7	2021	When CAR cells were treated with AITC, activation of caspase-3 and caspase-9 by AITC was observed and could be reversed by Z-VAD-fmk (pan-caspase inhibitor).	allyl isothiocyanate	33-37	caspase 9	Homo sapiens	67-76
32624316-7	2021	When CAR cells were treated with AITC, activation of caspase-3 and caspase-9 by AITC was observed and could be reversed by Z-VAD-fmk (pan-caspase inhibitor).	allyl isothiocyanate	33-37	caspase 9	Homo sapiens	53-60
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	mechanistic target of rapamycin kinase	Homo sapiens	99-128
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	mechanistic target of rapamycin kinase	Homo sapiens	132-136
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	CXADR pseudogene 1	Homo sapiens	170-173
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	BCL2 associated X, apoptosis regulator	Homo sapiens	212-215
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	cytochrome c, somatic	Homo sapiens	217-229
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	apoptotic peptidase activating factor 1	Homo sapiens	231-237
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	caspase 3	Homo sapiens	247-256
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	caspase 9	Homo sapiens	270-279
32624316-8	2021	Furthermore, the protein expressions of phosphorylated protein kinase B (p-AKT) and phosphorylated mammalian target of rapamycin (p-mTOR) were suppressed in AITC-treated CAR cells, whereas protein expressions of Bax, cytochrome c, Apaf-1, cleaved caspase-3, and cleaved caspase-9 were upregulated in AITC-treated CAR cells.	allyl isothiocyanate	157-161	CXADR pseudogene 1	Homo sapiens	313-316
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	12-16	AKT serine/threonine kinase 1	Homo sapiens	29-32
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	12-16	mechanistic target of rapamycin kinase	Homo sapiens	33-37
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	12-16	caspase 3	Homo sapiens	151-160
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	12-16	caspase 9	Homo sapiens	165-174
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	12-16	CXADR pseudogene 1	Homo sapiens	178-181
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	123-127	caspase 3	Homo sapiens	151-160
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	123-127	caspase 9	Homo sapiens	165-174
32624316-9	2021	CONCLUSION: AITC can inhibit Akt/mTOR proliferation signaling and promote mitochondria-dependent apoptotic pathway through AITC-enhanced activities of caspase-3 and caspase-9 in CAR cells.	allyl isothiocyanate	123-127	CXADR pseudogene 1	Homo sapiens	178-181
33458442-0	2021	Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1.	allyl isothiocyanate	0-20	transient receptor potential cation channel subfamily A member 1	Homo sapiens	121-126
33458442-0	2021	Allyl isothiocyanate (AITC) activates nonselective cation currents in human cardiac fibroblasts: possible involvement of TRPA1.	allyl isothiocyanate	22-26	transient receptor potential cation channel subfamily A member 1	Homo sapiens	121-126
33458442-8	2021	The present study shows the first evidence for functional Ca2+-permeable nonselective cation currents induced by AITC, possibly via TRPA1 in human cardiac fibroblast.	allyl isothiocyanate	113-117	transient receptor potential cation channel subfamily A member 1	Homo sapiens	132-137
33320598-5	2020	In this study, we utilized our 3D in vitro cornea-like tissue model to study the effects of irritation mediated by transient receptor potential (TRP) channels vanilloid 1 and ankyrin 1 (TRPV1; TRPA1) in response to allyl isothiocyanate (AITC) stimulation.	allyl isothiocyanate	215-235	transient receptor potential cation channel subfamily V member 1	Homo sapiens	186-191
33320598-5	2020	In this study, we utilized our 3D in vitro cornea-like tissue model to study the effects of irritation mediated by transient receptor potential (TRP) channels vanilloid 1 and ankyrin 1 (TRPV1; TRPA1) in response to allyl isothiocyanate (AITC) stimulation.	allyl isothiocyanate	215-235	transient receptor potential cation channel subfamily A member 1	Homo sapiens	193-198
33320598-5	2020	In this study, we utilized our 3D in vitro cornea-like tissue model to study the effects of irritation mediated by transient receptor potential (TRP) channels vanilloid 1 and ankyrin 1 (TRPV1; TRPA1) in response to allyl isothiocyanate (AITC) stimulation.	allyl isothiocyanate	237-241	transient receptor potential cation channel subfamily V member 1	Homo sapiens	186-191
33320598-5	2020	In this study, we utilized our 3D in vitro cornea-like tissue model to study the effects of irritation mediated by transient receptor potential (TRP) channels vanilloid 1 and ankyrin 1 (TRPV1; TRPA1) in response to allyl isothiocyanate (AITC) stimulation.	allyl isothiocyanate	237-241	transient receptor potential cation channel subfamily A member 1	Homo sapiens	193-198
32415670-12	2021	CONCLUSION AND IMPLICATIONS: AITC-induced DBF is a suitable target engagement biomarker of TRPA1 activity for preclinical and clinical studies of TRPA1 antagonists.	allyl isothiocyanate	29-33	transient receptor potential cation channel subfamily A member 1	Homo sapiens	91-96
32415670-12	2021	CONCLUSION AND IMPLICATIONS: AITC-induced DBF is a suitable target engagement biomarker of TRPA1 activity for preclinical and clinical studies of TRPA1 antagonists.	allyl isothiocyanate	29-33	transient receptor potential cation channel subfamily A member 1	Homo sapiens	146-151
33238403-0	2020	Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte.	allyl isothiocyanate	0-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	69-73
33238403-5	2020	Notably, AITC is known for activating nuclear factor erythroid 2-related factor 2 (NRF2), but there is limited evidence supporting the beneficial effects on hepatocytes and liver, where AITC is mainly metabolized.	allyl isothiocyanate	9-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	38-81
33238403-5	2020	Notably, AITC is known for activating nuclear factor erythroid 2-related factor 2 (NRF2), but there is limited evidence supporting the beneficial effects on hepatocytes and liver, where AITC is mainly metabolized.	allyl isothiocyanate	9-13	nuclear factor, erythroid derived 2, like 2	Mus musculus	83-87
33238403-7	2020	Furthermore, NRF2 nuclear translocation and the increase of target genes by AITC treatment were confirmed by in vitro experiments.	allyl isothiocyanate	76-80	nuclear factor, erythroid derived 2, like 2	Mus musculus	13-17
33238403-8	2020	APAP-induced cell damage was attenuated by AITC via an NRF2-dependent manner, and rapid NRF2 activation by AITC was attributed to the elevation of NRF2 stability by decreasing its spontaneous degradation.	allyl isothiocyanate	107-111	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
33238403-8	2020	APAP-induced cell damage was attenuated by AITC via an NRF2-dependent manner, and rapid NRF2 activation by AITC was attributed to the elevation of NRF2 stability by decreasing its spontaneous degradation.	allyl isothiocyanate	107-111	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	64-68	heme oxygenase 1	Mus musculus	97-113
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	64-68	heme oxygenase 1	Mus musculus	115-119
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	64-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	64-68	nuclear factor, erythroid derived 2, like 2	Mus musculus	217-221
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	171-175	heme oxygenase 1	Mus musculus	97-113
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	171-175	heme oxygenase 1	Mus musculus	115-119
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	171-175	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-129
33238403-9	2020	Moreover, liver tissues from our mouse experiment revealed that AITC increases the expression of heme oxygenase-1 (HO-1), an NRF2 target gene, confirming the potential of AITC as a hepatoprotective agent that induces NRF2 activation.	allyl isothiocyanate	171-175	nuclear factor, erythroid derived 2, like 2	Mus musculus	217-221
33238403-10	2020	Taken together, our results indicate the potential of AITC as a natural-product-derived NRF2 activator targeting the liver.	allyl isothiocyanate	54-58	nuclear factor, erythroid derived 2, like 2	Mus musculus	88-92
32708653-6	2020	We showed that RvD1 and RvD2 in nanomolar concentrations significantly decreased TRPV1 and TRPA1 activation on sensory neurons by fluorescent calcium imaging and inhibited the CAPS- and AITC-evoked 45Ca-uptake on TRPV1- and TRPA1-expressing CHO cells.	allyl isothiocyanate	186-190	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	213-218
33093270-0	2020	AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	0-4	ATP binding cassette subfamily C member 1	Homo sapiens	13-17
33093270-0	2020	AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	0-4	citrate synthase	Homo sapiens	51-53
33093270-0	2020	AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	0-4	Parkinsonism associated deglycase	Homo sapiens	67-71
33093270-0	2020	AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	0-4	Parkinsonism associated deglycase	Homo sapiens	114-118
33093270-0	2020	AITC induces MRP1 expression by protecting against CS/CSE-mediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	0-4	NFE2 like bZIP transcription factor 2	Homo sapiens	119-123
33093270-5	2020	The expression of DJ-1, Nrf2, HO-1, and MRP1 was significantly decreased in the wild type model group, while the expression of each protein was significantly increased after administration of AITC.	allyl isothiocyanate	192-196	Parkinsonism associated deglycase	Homo sapiens	18-22
33093270-5	2020	The expression of DJ-1, Nrf2, HO-1, and MRP1 was significantly decreased in the wild type model group, while the expression of each protein was significantly increased after administration of AITC.	allyl isothiocyanate	192-196	NFE2 like bZIP transcription factor 2	Homo sapiens	24-28
33093270-6	2020	Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1.	allyl isothiocyanate	126-130	Parkinsonism associated deglycase	Homo sapiens	28-32
33093270-6	2020	Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1.	allyl isothiocyanate	126-130	NFE2 like bZIP transcription factor 2	Homo sapiens	170-174
33093270-6	2020	Silencing the expression of DJ-1 in 16HBE cells accelerated CSE-induced protein degradation, and significantly attenuated the AITC-induced mRNA and protein expression of Nrf2 and MRP1.	allyl isothiocyanate	126-130	ATP binding cassette subfamily C member 1	Homo sapiens	179-183
33093270-7	2020	The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	55-59	ATP binding cassette subfamily C member 1	Homo sapiens	68-72
33093270-7	2020	The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	55-59	citrate synthase	Homo sapiens	106-108
33093270-7	2020	The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	55-59	Parkinsonism associated deglycase	Homo sapiens	121-125
33093270-7	2020	The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	55-59	Parkinsonism associated deglycase	Homo sapiens	168-172
33093270-7	2020	The present study describes a novel mechanism by which AITC induces MRP1 expression by protecting against CS/CSEmediated DJ-1 protein degradation via activation of the DJ-1/Nrf2 axis.	allyl isothiocyanate	55-59	NFE2 like bZIP transcription factor 2	Homo sapiens	173-177
32700751-6	2020	AITC also triggered vital intrinsic apoptotic factors (caspase-9/caspase-3 activity), disrupted mitochondrial membrane potential, and stimulated mitochondrial-related apoptotic molecules (e.g., cytochrome c, apoptotic protease activating factor 1, apoptosis-inducing factor, and endonuclease G).	allyl isothiocyanate	0-4	caspase 9	Homo sapiens	55-64
32700751-6	2020	AITC also triggered vital intrinsic apoptotic factors (caspase-9/caspase-3 activity), disrupted mitochondrial membrane potential, and stimulated mitochondrial-related apoptotic molecules (e.g., cytochrome c, apoptotic protease activating factor 1, apoptosis-inducing factor, and endonuclease G).	allyl isothiocyanate	0-4	caspase 3	Homo sapiens	65-74
32700751-6	2020	AITC also triggered vital intrinsic apoptotic factors (caspase-9/caspase-3 activity), disrupted mitochondrial membrane potential, and stimulated mitochondrial-related apoptotic molecules (e.g., cytochrome c, apoptotic protease activating factor 1, apoptosis-inducing factor, and endonuclease G).	allyl isothiocyanate	0-4	cytochrome c, somatic	Homo sapiens	194-206
32700751-6	2020	AITC also triggered vital intrinsic apoptotic factors (caspase-9/caspase-3 activity), disrupted mitochondrial membrane potential, and stimulated mitochondrial-related apoptotic molecules (e.g., cytochrome c, apoptotic protease activating factor 1, apoptosis-inducing factor, and endonuclease G).	allyl isothiocyanate	0-4	apoptotic peptidase activating factor 1	Homo sapiens	208-246
32700751-7	2020	Additionally, AITC prompted induced cytosolic Ca2+ release and Ca2+-dependent ER stress-related signals, such as calpain 1, activating transcription factor 6alpha, glucose-regulated proteins 78 and 94, growth arrest- and DNA damage-inducible protein 153 (GADD153), and caspase-4.	allyl isothiocyanate	14-18	calpain 1	Homo sapiens	113-122
32700751-7	2020	Additionally, AITC prompted induced cytosolic Ca2+ release and Ca2+-dependent ER stress-related signals, such as calpain 1, activating transcription factor 6alpha, glucose-regulated proteins 78 and 94, growth arrest- and DNA damage-inducible protein 153 (GADD153), and caspase-4.	allyl isothiocyanate	14-18	DNA damage inducible transcript 3	Homo sapiens	202-253
32700751-7	2020	Additionally, AITC prompted induced cytosolic Ca2+ release and Ca2+-dependent ER stress-related signals, such as calpain 1, activating transcription factor 6alpha, glucose-regulated proteins 78 and 94, growth arrest- and DNA damage-inducible protein 153 (GADD153), and caspase-4.	allyl isothiocyanate	14-18	DNA damage inducible transcript 3	Homo sapiens	255-262
32700751-7	2020	Additionally, AITC prompted induced cytosolic Ca2+ release and Ca2+-dependent ER stress-related signals, such as calpain 1, activating transcription factor 6alpha, glucose-regulated proteins 78 and 94, growth arrest- and DNA damage-inducible protein 153 (GADD153), and caspase-4.	allyl isothiocyanate	14-18	caspase 4	Homo sapiens	269-278
32700751-8	2020	The level of reactive oxygen species (ROS) production was found to induce the hallmark of ER stress GADD153, proapoptotic marker caspase-3, and calpain activity after AITC treatment.	allyl isothiocyanate	167-171	DNA damage inducible transcript 3	Homo sapiens	100-107
32700751-8	2020	The level of reactive oxygen species (ROS) production was found to induce the hallmark of ER stress GADD153, proapoptotic marker caspase-3, and calpain activity after AITC treatment.	allyl isothiocyanate	167-171	caspase 3	Homo sapiens	129-138
33117171-1	2020	Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.	allyl isothiocyanate	121-141	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-38
33117171-1	2020	Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.	allyl isothiocyanate	121-141	transient receptor potential cation channel subfamily A member 1	Homo sapiens	40-45
33117171-1	2020	Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.	allyl isothiocyanate	143-147	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-38
33117171-1	2020	Transient receptor potential ankyrin 1 (TRPA1) channel is an ion channel whose gating is controlled by agonists, such as allyl isothiocyanate (AITC), and temperature.	allyl isothiocyanate	143-147	transient receptor potential cation channel subfamily A member 1	Homo sapiens	40-45
33117171-7	2020	Negative phototaxis was induced by TRPA1 agonists, such as icilin and AITC, at high temperatures.	allyl isothiocyanate	70-74	transient receptor potential cation channel subfamily A member 1	Homo sapiens	35-40
32698003-4	2020	In vS1, local activation of TRPA1 by allyl isothiocyanate (AITC) increases the ongoing activity of neurons and their evoked response to vibrissal stimulation, producing a positive gain modulation.	allyl isothiocyanate	37-57	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	28-33
32698003-4	2020	In vS1, local activation of TRPA1 by allyl isothiocyanate (AITC) increases the ongoing activity of neurons and their evoked response to vibrissal stimulation, producing a positive gain modulation.	allyl isothiocyanate	59-63	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	28-33
32708653-6	2020	We showed that RvD1 and RvD2 in nanomolar concentrations significantly decreased TRPV1 and TRPA1 activation on sensory neurons by fluorescent calcium imaging and inhibited the CAPS- and AITC-evoked 45Ca-uptake on TRPV1- and TRPA1-expressing CHO cells.	allyl isothiocyanate	186-190	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily A member 1	Cricetulus griseus	224-229
32233794-4	2020	The TRPA1 agonists allyl isothiocyanate (AITC) and cinnamaldehyde (CINN) were tested in sedated, mechanically ventilated guinea pigs in vivo.	allyl isothiocyanate	19-39	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	4-9
32481567-4	2020	Cooling to 12  C, E. coli LPS and allyl isothiocyanate (AITC) induced robust Ca2+ responses in CHO-K1 cells stably transfected with mTRPA1.	allyl isothiocyanate	34-54	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	132-138
32481567-4	2020	Cooling to 12  C, E. coli LPS and allyl isothiocyanate (AITC) induced robust Ca2+ responses in CHO-K1 cells stably transfected with mTRPA1.	allyl isothiocyanate	56-60	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	132-138
32320793-8	2020	Similarly, a TRPA1 agonist, allyl isothiocyanate (AITC; mustard oil), stimulated SMA relaxation dependent on TRPA1, endothelium, NO, and GC.	allyl isothiocyanate	28-48	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	13-18
32320793-8	2020	Similarly, a TRPA1 agonist, allyl isothiocyanate (AITC; mustard oil), stimulated SMA relaxation dependent on TRPA1, endothelium, NO, and GC.	allyl isothiocyanate	28-48	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	109-114
32320793-8	2020	Similarly, a TRPA1 agonist, allyl isothiocyanate (AITC; mustard oil), stimulated SMA relaxation dependent on TRPA1, endothelium, NO, and GC.	allyl isothiocyanate	50-54	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	13-18
32320793-8	2020	Similarly, a TRPA1 agonist, allyl isothiocyanate (AITC; mustard oil), stimulated SMA relaxation dependent on TRPA1, endothelium, NO, and GC.	allyl isothiocyanate	50-54	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	109-114
32380698-9	2020	The in vitro half maximal inhibitory concentration (IC50)values of AITC, 2PEITC and 3MPITC for GST were 3.32, 0.61 and 0.66 microg/microL, respectively.	allyl isothiocyanate	67-71	glutathione S-transferase-like	Solenopsis invicta	95-98
32233794-13	2020	AITC- and CINN-induced airway relaxation required TRPA1, prostaglandins, and PGE2 receptor activation.	allyl isothiocyanate	0-4	transient receptor potential cation channel subfamily A member 1	Homo sapiens	50-55
31747319-0	2020	Allyl isothiocyanate up-regulates MRP1 expression through Notch1 signaling in human bronchial epithelial cells.	allyl isothiocyanate	0-20	ATP binding cassette subfamily C member 1	Homo sapiens	34-38
31747319-0	2020	Allyl isothiocyanate up-regulates MRP1 expression through Notch1 signaling in human bronchial epithelial cells.	allyl isothiocyanate	0-20	notch receptor 1	Homo sapiens	58-64
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	128-148	transient receptor potential cation channel subfamily A member 1	Homo sapiens	81-86
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	128-148	tumor necrosis factor	Homo sapiens	39-48
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	128-148	transient receptor potential cation channel subfamily A member 1	Homo sapiens	114-119
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	128-148	transient receptor potential cation channel subfamily A member 1	Homo sapiens	114-119
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	150-154	tumor necrosis factor	Homo sapiens	39-48
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	150-154	transient receptor potential cation channel subfamily A member 1	Homo sapiens	81-86
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	150-154	transient receptor potential cation channel subfamily A member 1	Homo sapiens	114-119
32050145-8	2020	Calcium imaging analysis revealed that TNF-alpha treatment apparently sensitized TRPA1-mediated calcium influx by TRPA1 agonist allyl isothiocyanate (AITC) and the selective TRPA1 channel blocker HC-030031 effectively reduced the calcium response.	allyl isothiocyanate	150-154	transient receptor potential cation channel subfamily A member 1	Homo sapiens	114-119
32365761-0	2020	Cell Death Effects Induced by Sulforaphane and Allyl Isothiocyanate on P-Glycoprotein Positive and Negative Variants in L1210 Cells.	allyl isothiocyanate	47-67	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
32388008-5	2020	Liquiritin inhibited capsaicin- and allyl isothiocyanate-evoked TRPV1 and TRPA1 whole-cell currents, respectively, with a similar potency and maximal inhibition.	allyl isothiocyanate	36-56	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	64-69
32388008-5	2020	Liquiritin inhibited capsaicin- and allyl isothiocyanate-evoked TRPV1 and TRPA1 whole-cell currents, respectively, with a similar potency and maximal inhibition.	allyl isothiocyanate	36-56	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	74-79
31790822-8	2020	The chemical hyperalgesia produced by a TRPA1 agonist (allyl isothiocyanate, AITC) was also detected.	allyl isothiocyanate	55-75	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	40-45
32451393-9	2020	DSS treatment increased expression of TRPA1 mRNA in cultured dorsal root ganglion (DRG) neurons, but not trigeminal ganglion neurons, and selectively enhanced currents evoked by the TRPA1 agonist, allyl isothiocyanate, in cultured DRG neurons.	allyl isothiocyanate	197-217	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	38-43
32451393-9	2020	DSS treatment increased expression of TRPA1 mRNA in cultured dorsal root ganglion (DRG) neurons, but not trigeminal ganglion neurons, and selectively enhanced currents evoked by the TRPA1 agonist, allyl isothiocyanate, in cultured DRG neurons.	allyl isothiocyanate	197-217	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	182-187
31944254-6	2020	In HBECs, MUC5AC was also induced by the transient receptor potential ankyrin-1 (TRPA1) agonists" coniferaldehyde, a component of pine smoke PM, and allyl isothiocyanate (AITC), and was attenuated by a TRPA1 antagonist.	allyl isothiocyanate	149-169	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	10-16
31944254-6	2020	In HBECs, MUC5AC was also induced by the transient receptor potential ankyrin-1 (TRPA1) agonists" coniferaldehyde, a component of pine smoke PM, and allyl isothiocyanate (AITC), and was attenuated by a TRPA1 antagonist.	allyl isothiocyanate	171-175	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	10-16
32402637-3	2020	TRPA1 is activated by electrophilic compounds, including dietary molecules such as allyl isothiocyanate, a derivative of mustard.	allyl isothiocyanate	83-103	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
31927049-0	2020	Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease through the Nrf2-Notch1 signaling and upregulation of MRP1.	allyl isothiocyanate	0-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	92-96
31927049-0	2020	Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease through the Nrf2-Notch1 signaling and upregulation of MRP1.	allyl isothiocyanate	0-20	notch 1	Mus musculus	97-103
31927049-0	2020	Allyl isothiocyanate treatment alleviates chronic obstructive pulmonary disease through the Nrf2-Notch1 signaling and upregulation of MRP1.	allyl isothiocyanate	0-20	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	134-138
31927049-3	2020	The purpose of this study was to investigate whether AITC regulated Multidrug resistance-associated protein 1 (MRP1), reactive oxide species (ROS) and reduced glutathione (GSH) levels via Nrf2 and Notch1 signaling pathways to treat COPD and whether there was an interaction between these two pathways.	allyl isothiocyanate	53-57	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	68-109
31927049-3	2020	The purpose of this study was to investigate whether AITC regulated Multidrug resistance-associated protein 1 (MRP1), reactive oxide species (ROS) and reduced glutathione (GSH) levels via Nrf2 and Notch1 signaling pathways to treat COPD and whether there was an interaction between these two pathways.	allyl isothiocyanate	53-57	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Mus musculus	111-115
31927049-3	2020	The purpose of this study was to investigate whether AITC regulated Multidrug resistance-associated protein 1 (MRP1), reactive oxide species (ROS) and reduced glutathione (GSH) levels via Nrf2 and Notch1 signaling pathways to treat COPD and whether there was an interaction between these two pathways.	allyl isothiocyanate	53-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	188-192
31927049-3	2020	The purpose of this study was to investigate whether AITC regulated Multidrug resistance-associated protein 1 (MRP1), reactive oxide species (ROS) and reduced glutathione (GSH) levels via Nrf2 and Notch1 signaling pathways to treat COPD and whether there was an interaction between these two pathways.	allyl isothiocyanate	53-57	notch 1	Mus musculus	197-203
32484015-5	2020	Like DRG neurons, dissociated SGCs exhibit a robust response to the TRPA1-selective agonist allyl isothiocyanate (AITC) by an increase of intracellular Ca2+ concentration ([Ca2+]i).	allyl isothiocyanate	92-112	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	68-73
32484015-5	2020	Like DRG neurons, dissociated SGCs exhibit a robust response to the TRPA1-selective agonist allyl isothiocyanate (AITC) by an increase of intracellular Ca2+ concentration ([Ca2+]i).	allyl isothiocyanate	114-118	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	68-73
31796582-2	2019	As a ligand-gated channel, TRPA1 can be activated by electrophilic compounds such as allyl isothiocyanate (AITC) through covalent modification or activated by noncovalent agonists through ligand binding.	allyl isothiocyanate	85-105	transient receptor potential cation channel subfamily A member 1	Homo sapiens	27-32
31796582-2	2019	As a ligand-gated channel, TRPA1 can be activated by electrophilic compounds such as allyl isothiocyanate (AITC) through covalent modification or activated by noncovalent agonists through ligand binding.	allyl isothiocyanate	107-111	transient receptor potential cation channel subfamily A member 1	Homo sapiens	27-32
31805147-4	2019	We found that chemicals known to activate TRPA1 (allyl isothiocyanate (AITC) and hydrogen peroxide) and TRPV (capsaicin and anandamide) in other systems induce scrunching in the planarian species Dugesia japonica and, except for anandamide, in Schmidtea mediterranea.	allyl isothiocyanate	49-69	transient receptor potential cation channel subfamily A member 1	Homo sapiens	42-47
31805147-4	2019	We found that chemicals known to activate TRPA1 (allyl isothiocyanate (AITC) and hydrogen peroxide) and TRPV (capsaicin and anandamide) in other systems induce scrunching in the planarian species Dugesia japonica and, except for anandamide, in Schmidtea mediterranea.	allyl isothiocyanate	71-75	transient receptor potential cation channel subfamily A member 1	Homo sapiens	42-47
31805147-6	2019	Unexpectedly, co-treatment with a mammalian TRPA1 antagonist, HC-030031, enhanced AITC-induced scrunching by decreasing the latency time, suggesting an agonistic relationship in planarians.	allyl isothiocyanate	82-86	transient receptor potential cation channel subfamily A member 1	Homo sapiens	44-49
31805147-7	2019	We further confirmed that TRPA1 in both planarian species is necessary for AITC-induced scrunching using RNAi.	allyl isothiocyanate	75-79	transient receptor potential cation channel subfamily A member 1	Homo sapiens	26-31
31488616-8	2019	TRPA1-specific activator namely allyl isothiocyanate (AITC) increases intracellular calcium ion (Ca2+) levels while two different inhibitors namely A-967079 as well as HC-030031 reduce intracellular Ca2+ levels in T cells; TRPA1 inhibition also reduces TCR-mediated calcium influx.	allyl isothiocyanate	54-58	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
31571144-0	2019	Allyl isothiocyanate may reverse the expression of MRP1 in COPD rats via the Notch1 signaling pathway.	allyl isothiocyanate	0-20	ATP binding cassette subfamily C member 1	Rattus norvegicus	51-55
31571144-0	2019	Allyl isothiocyanate may reverse the expression of MRP1 in COPD rats via the Notch1 signaling pathway.	allyl isothiocyanate	0-20	notch receptor 1	Rattus norvegicus	77-83
31488616-8	2019	TRPA1-specific activator namely allyl isothiocyanate (AITC) increases intracellular calcium ion (Ca2+) levels while two different inhibitors namely A-967079 as well as HC-030031 reduce intracellular Ca2+ levels in T cells; TRPA1 inhibition also reduces TCR-mediated calcium influx.	allyl isothiocyanate	54-58	transient receptor potential cation channel subfamily A member 1	Homo sapiens	223-228
31277262-9	2019	Moreover, inhibition of A-kinase anchoring protein (AKAP) significantly decreased the carboplatin-induced enhancement of [Ca2+]i induced by AITC and improved carboplatin-induced mechanical allodynia and cold hyperalgesia.	allyl isothiocyanate	140-144	A-kinase anchoring protein 13	Homo sapiens	24-50
31558861-0	2019	Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-kappaB signaling pathways.	allyl isothiocyanate	0-20	sirtuin 1	Mus musculus	113-118
31558861-0	2019	Allyl isothiocyanate ameliorates lipid accumulation and inflammation in nonalcoholic fatty liver disease via the Sirt1/AMPK and NF-kappaB signaling pathways.	allyl isothiocyanate	0-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	128-137
31558861-7	2019	Mechanistically, AITC significantly downregulated the protein levels of sterol regulatory element-binding protein 1 (SREBP1) and its lipogenesis target genes and upregulated the levels of proteins involved in fatty acid beta-oxidation, as well as the upstream mediators Sirtuin 1 (Sirt1) and AMP-activated protein kinase alpha (AMPKalpha), in the livers of HFD-fed mice.	allyl isothiocyanate	17-21	sterol regulatory element binding transcription factor 1	Mus musculus	72-115
31558861-7	2019	Mechanistically, AITC significantly downregulated the protein levels of sterol regulatory element-binding protein 1 (SREBP1) and its lipogenesis target genes and upregulated the levels of proteins involved in fatty acid beta-oxidation, as well as the upstream mediators Sirtuin 1 (Sirt1) and AMP-activated protein kinase alpha (AMPKalpha), in the livers of HFD-fed mice.	allyl isothiocyanate	17-21	sterol regulatory element binding transcription factor 1	Mus musculus	117-123
31558861-7	2019	Mechanistically, AITC significantly downregulated the protein levels of sterol regulatory element-binding protein 1 (SREBP1) and its lipogenesis target genes and upregulated the levels of proteins involved in fatty acid beta-oxidation, as well as the upstream mediators Sirtuin 1 (Sirt1) and AMP-activated protein kinase alpha (AMPKalpha), in the livers of HFD-fed mice.	allyl isothiocyanate	17-21	sirtuin 1	Mus musculus	270-279
31558861-7	2019	Mechanistically, AITC significantly downregulated the protein levels of sterol regulatory element-binding protein 1 (SREBP1) and its lipogenesis target genes and upregulated the levels of proteins involved in fatty acid beta-oxidation, as well as the upstream mediators Sirtuin 1 (Sirt1) and AMP-activated protein kinase alpha (AMPKalpha), in the livers of HFD-fed mice.	allyl isothiocyanate	17-21	sirtuin 1	Mus musculus	281-286
31558861-8	2019	AITC also attenuated the nuclear factor kappa B (NF-kappaB) signaling pathway.	allyl isothiocyanate	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-47
31558861-8	2019	AITC also attenuated the nuclear factor kappa B (NF-kappaB) signaling pathway.	allyl isothiocyanate	0-4	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	49-58
31558861-9	2019	Consistently, AITC relieved palmitate acid-induced lipid accumulation and inflammation in AML-12 cells in vitro through the Sirt1/AMPK and NF-kappaB signaling pathways.	allyl isothiocyanate	14-18	sirtuin 1	Mus musculus	124-129
31558861-9	2019	Consistently, AITC relieved palmitate acid-induced lipid accumulation and inflammation in AML-12 cells in vitro through the Sirt1/AMPK and NF-kappaB signaling pathways.	allyl isothiocyanate	14-18	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	139-148
31558861-10	2019	Importantly, further studies showed that the curative effect of AITC on lipid accumulation was abolished by siRNA-mediated knockdown of either Sirt1 or AMPKalpha in AML-12 cells.	allyl isothiocyanate	64-68	sirtuin 1	Mus musculus	143-148
31558861-11	2019	CONCLUSION: AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-kappaB pathway.	allyl isothiocyanate	12-16	sirtuin 1	Mus musculus	96-101
31558861-11	2019	CONCLUSION: AITC significantly ameliorates hepatic steatosis and inflammation by activating the Sirt1/AMPK pathway and inhibiting the NF-kappaB pathway.	allyl isothiocyanate	12-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
31132686-0	2019	Effect of TRPA1 activator allyl isothiocyanate (AITC) on rat dural and pial arteries.	allyl isothiocyanate	48-52	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	10-15
31132686-5	2019	In this study we aim to compare and characterize the effect of the TRPA1 agonist allyl isothiocyanate (AITC) on the diameter of rat dural and pial arteries in vivo.	allyl isothiocyanate	81-101	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	67-72
31132686-5	2019	In this study we aim to compare and characterize the effect of the TRPA1 agonist allyl isothiocyanate (AITC) on the diameter of rat dural and pial arteries in vivo.	allyl isothiocyanate	103-107	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	67-72
31132686-11	2019	CONCLUSION: AITC causes dilation of dural arteries via a mechanism dependent on CGRP and TRPA1 that is sensitive to sumatriptan.	allyl isothiocyanate	12-16	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
31132686-11	2019	CONCLUSION: AITC causes dilation of dural arteries via a mechanism dependent on CGRP and TRPA1 that is sensitive to sumatriptan.	allyl isothiocyanate	12-16	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	89-94
31277262-9	2019	Moreover, inhibition of A-kinase anchoring protein (AKAP) significantly decreased the carboplatin-induced enhancement of [Ca2+]i induced by AITC and improved carboplatin-induced mechanical allodynia and cold hyperalgesia.	allyl isothiocyanate	140-144	A-kinase anchoring protein 13	Homo sapiens	52-56
30819885-4	2019	Here we show that both excretory-secretory products (E-S) and extract of T. spiralis can stimulate the release of the cytokine interleukin 25 (IL-25) from the mouse small intestinal villi and evoke calcium responses from tuft cells in the intestinal organoids, which can be blocked by a bitter-taste receptor inhibitor, allyl isothiocyanate.	allyl isothiocyanate	320-340	interleukin 25	Mus musculus	143-148
30679204-2	2019	TRPA1, a member of TRP channel family, is specifically activated by natural products such as allyl isothiocyanate (mustard oil), cinnamaldehyde (cinnamon), and allicin (garlic).	allyl isothiocyanate	93-113	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
30679204-8	2019	Conversely, activation of TRPA1 by the electrophile allyl isothiocyanate was abolished by glutathione, but was ostensibly unaffected by mutation of the ST binding site.	allyl isothiocyanate	52-72	transient receptor potential cation channel subfamily A member 1	Homo sapiens	26-31
31488616-8	2019	TRPA1-specific activator namely allyl isothiocyanate (AITC) increases intracellular calcium ion (Ca2+) levels while two different inhibitors namely A-967079 as well as HC-030031 reduce intracellular Ca2+ levels in T cells; TRPA1 inhibition also reduces TCR-mediated calcium influx.	allyl isothiocyanate	32-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
31488616-8	2019	TRPA1-specific activator namely allyl isothiocyanate (AITC) increases intracellular calcium ion (Ca2+) levels while two different inhibitors namely A-967079 as well as HC-030031 reduce intracellular Ca2+ levels in T cells; TRPA1 inhibition also reduces TCR-mediated calcium influx.	allyl isothiocyanate	32-52	transient receptor potential cation channel subfamily A member 1	Homo sapiens	223-228
31170994-3	2019	METHODS: Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity.	allyl isothiocyanate	42-62	transient receptor potential cation channel subfamily A member 1	Homo sapiens	27-32
31170994-3	2019	METHODS: Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity.	allyl isothiocyanate	42-62	transient receptor potential cation channel subfamily A member 1	Homo sapiens	126-131
31170994-3	2019	METHODS: Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity.	allyl isothiocyanate	64-68	transient receptor potential cation channel subfamily A member 1	Homo sapiens	27-32
31170994-3	2019	METHODS: Using a selective TRPA1 agonist, allyl isothiocyanate (AITC), we established an AITC cough challenge as a measure of TRPA1-mediated cough sensitivity.	allyl isothiocyanate	64-68	transient receptor potential cation channel subfamily A member 1	Homo sapiens	126-131
31170994-8	2019	Cough sensitivity to AITC and capsaicin was significantly higher in patients than in healthy subjects (AITC: 2.42 [2.37-2.48] vs 2.72 [2.66-2.78] mM, p = 0.001; capsaicin: 1.87 [1.75-1.98] vs 2.53 [2.36-2.70] muM, p = 0.001) and was higher in females than in males for both healthy subjects and patients (all p &lt; 0.05).	allyl isothiocyanate	21-25	latexin	Homo sapiens	209-212
30841847-10	2019	Further, blockade of CGRP prolonged CSD latency, which was reversed by H2O2 and the TRPA1 agonist, allyl-isothiocyanate, respectively.	allyl isothiocyanate	99-119	calcitonin-related polypeptide alpha	Rattus norvegicus	21-25
30841847-10	2019	Further, blockade of CGRP prolonged CSD latency, which was reversed by H2O2 and the TRPA1 agonist, allyl-isothiocyanate, respectively.	allyl isothiocyanate	99-119	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	84-89
30636360-7	2019	After exposure to safranal the ability of allyl isothiocyanate (TRPA1 agonist), but not that of capsaicin (TRPV1 agonist) or GSK1016790A (TRPV4 agonist), to evoke currents in DRG neurons, contraction of urinary bladder strips and CGRP release from spinal cord slices in rats, and acute nociception in mice underwent desensitization.	allyl isothiocyanate	42-62	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	64-69
30636360-7	2019	After exposure to safranal the ability of allyl isothiocyanate (TRPA1 agonist), but not that of capsaicin (TRPV1 agonist) or GSK1016790A (TRPV4 agonist), to evoke currents in DRG neurons, contraction of urinary bladder strips and CGRP release from spinal cord slices in rats, and acute nociception in mice underwent desensitization.	allyl isothiocyanate	42-62	calcitonin-related polypeptide alpha	Rattus norvegicus	230-234
30406889-0	2019	Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappaB pathways in traumatic brain injury in mice.	allyl isothiocyanate	0-20	nuclear factor, erythroid derived 2, like 2	Mus musculus	80-84
31216970-3	2019	Substances that activate TRPA1, e.g., allyl isothiocyanates (pungent components of mustard, horseradish, and wasabi), cinnamaldehyde from cinnamon, organosulfur compounds from garlic and onion, tear gas, acrolein and crotonaldehyde from cigarette smoke, etc., cause burning, mechanical and thermal hypersensitivity, cough, eye irritation, sneezing, mucus secretion, and neurogenic inflammation.	allyl isothiocyanate	38-59	transient receptor potential cation channel subfamily A member 1	Homo sapiens	25-30
30406889-0	2019	Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappaB pathways in traumatic brain injury in mice.	allyl isothiocyanate	0-20	heme oxygenase 1	Mus musculus	85-89
29282753-5	2018	The magnitude of 15K-induced [Ca2+ ]i increase was significantly larger in neurons sensitive to allylisothiocyanate (AITC, a TRPA1 agonist) than in those insensitive to it, and in TRPA1-/- mouse sensory neurons.	allyl isothiocyanate	117-121	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	125-130
30406889-0	2019	Allyl isothiocyanate attenuates oxidative stress and inflammation by modulating Nrf2/HO-1 and NF-kappaB pathways in traumatic brain injury in mice.	allyl isothiocyanate	0-20	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	94-103
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	70-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-149
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	70-90	nuclear factor, erythroid derived 2, like 2	Mus musculus	151-155
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	70-90	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	161-183
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	70-90	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	185-194
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	92-96	nuclear factor, erythroid derived 2, like 2	Mus musculus	106-149
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	92-96	nuclear factor, erythroid derived 2, like 2	Mus musculus	151-155
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	92-96	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	161-183
30406889-4	2019	To analyze the effects of a naturally occurring antioxidant molecule, allyl isothiocyanate (AITC), on the nuclear factor erythroid 2-related factor 2 (Nrf2) and nuclear factor kappa B (NF-kappaB) signaling pathways in TBI, a cryogenic injury model was induced in mice.	allyl isothiocyanate	92-96	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	185-194
30236550-6	2018	The concentration of the TRPA1 antagonist (HC-030031, 0.05%) on base cream was chosen using allyl isothiocyanate intraplantar test.	allyl isothiocyanate	92-112	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	25-30
30284468-0	2018	Allyl Isothiocyanate Induces Autophagy through the Up-Regulation of Beclin-1 in Human Prostate Cancer Cells.	allyl isothiocyanate	0-20	beclin 1	Homo sapiens	68-76
29369741-7	2018	3) Pretreatment with HC-030031, a selective TRPA1 antagonist, abolished the bronchoconstriction induced by allyl isothiocyanate, a selective TRPA1 agonist, but did not attenuate the nicotine-evoked bronchoconstriction.	allyl isothiocyanate	107-127	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	44-49
29369741-7	2018	3) Pretreatment with HC-030031, a selective TRPA1 antagonist, abolished the bronchoconstriction induced by allyl isothiocyanate, a selective TRPA1 agonist, but did not attenuate the nicotine-evoked bronchoconstriction.	allyl isothiocyanate	107-127	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	141-146
29719223-8	2018	Furthermore, the TRPA1 agonist, allyl-isothiocyanate (AITC), reversed the suppression of CSD by HC-030031, but not by A967079.	allyl isothiocyanate	32-52	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	17-22
29719223-8	2018	Furthermore, the TRPA1 agonist, allyl-isothiocyanate (AITC), reversed the suppression of CSD by HC-030031, but not by A967079.	allyl isothiocyanate	54-58	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	17-22
30002285-0	2018	Allyl Isothiocyanate Ameliorates Dextran Sodium Sulfate-Induced Colitis in Mouse by Enhancing Tight Junction and Mucin Expression.	allyl isothiocyanate	0-20	LOC100508689	Homo sapiens	113-118
30018539-10	2018	Using a calcium reporter, we observed AITC-evoked responses in both painless and dTRPA1 expressing neurons.	allyl isothiocyanate	38-42	Transient receptor potential cation channel A1	Drosophila melanogaster	81-87
29669958-1	2018	Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl4).	allyl isothiocyanate	0-20	C-C motif chemokine ligand 4	Rattus norvegicus	133-137
29669958-1	2018	Allyl isothiocyanate (AITC), a metabolite of the glucosinolate sinigrin, protects the liver of rats injured by carbon tetrachloride (CCl4).	allyl isothiocyanate	22-26	C-C motif chemokine ligand 4	Rattus norvegicus	133-137
29282753-6	2018	TRPA1 blockers diminished the [Ca2+ ]i responses to 15K in neurons sensitive to AITC, but failed to inhibit 40 mM KCl-induced [Ca2+ ]i increases even in AITC-sensitive neurons.	allyl isothiocyanate	80-84	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
29345776-0	2018	Allyl Isothiocyanate Ameliorates Obesity by Inhibiting Galectin-12.	allyl isothiocyanate	0-20	lectin, galactose binding, soluble 12	Mus musculus	55-66
29207921-0	2018	Allyl isothiocyanate increases carbohydrate oxidation through enhancing insulin secretion by TRPV1.	allyl isothiocyanate	0-20	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	93-98
29207921-2	2018	While, we have previously shown that intragastric administration of allyl isothiocyanate (AITC) enhanced glucose metabolism via TRPV1, the underlying mechanism has not been elucidated.	allyl isothiocyanate	68-88	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	128-133
29207921-2	2018	While, we have previously shown that intragastric administration of allyl isothiocyanate (AITC) enhanced glucose metabolism via TRPV1, the underlying mechanism has not been elucidated.	allyl isothiocyanate	90-94	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	128-133
29352128-5	2018	Calcium imaging of trigeminal ganglion neurons from genetically engineered mice overexpressing or lacking the Cdk5 activator p35 displayed increased or decreased responsiveness, respectively, to stimulation with the TRPA1 agonist allylisothiocyanate (AITC).	allyl isothiocyanate	230-249	cyclin-dependent kinase 5	Mus musculus	110-114
29352128-5	2018	Calcium imaging of trigeminal ganglion neurons from genetically engineered mice overexpressing or lacking the Cdk5 activator p35 displayed increased or decreased responsiveness, respectively, to stimulation with the TRPA1 agonist allylisothiocyanate (AITC).	allyl isothiocyanate	230-249	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	125-128
29352128-5	2018	Calcium imaging of trigeminal ganglion neurons from genetically engineered mice overexpressing or lacking the Cdk5 activator p35 displayed increased or decreased responsiveness, respectively, to stimulation with the TRPA1 agonist allylisothiocyanate (AITC).	allyl isothiocyanate	230-249	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	216-221
29352128-5	2018	Calcium imaging of trigeminal ganglion neurons from genetically engineered mice overexpressing or lacking the Cdk5 activator p35 displayed increased or decreased responsiveness, respectively, to stimulation with the TRPA1 agonist allylisothiocyanate (AITC).	allyl isothiocyanate	251-255	cyclin-dependent kinase 5	Mus musculus	110-114
29348534-7	2018	In addition, AITC-SiQDs showed a lower and long-lasting activation of Nrf2 translocation into nucleus which correlated with their levels of cellular uptake, as detected by the intrinsic fluorescence of SiQDs.	allyl isothiocyanate	13-17	NFE2 like bZIP transcription factor 2	Homo sapiens	70-74
29352128-5	2018	Calcium imaging of trigeminal ganglion neurons from genetically engineered mice overexpressing or lacking the Cdk5 activator p35 displayed increased or decreased responsiveness, respectively, to stimulation with the TRPA1 agonist allylisothiocyanate (AITC).	allyl isothiocyanate	251-255	cyclin-dependent kinase 5, regulatory subunit 1 (p35)	Mus musculus	125-128
28501931-5	2018	RESULTS: Administration of AITC (20 mg/kg bw) to carcinogen-injected rats significantly decreased the expression of NF-kappaB p65, TNF-alpha, and IL-6 in mammary tissues.	allyl isothiocyanate	27-31	synaptotagmin 1	Rattus norvegicus	126-129
29111112-4	2018	Microinjection of the TRPA1 agonist allyl isothiocyanate (AITC) onto the dura mater produced migraine-like pain for 3h as measured by depression of home cage wheel running.	allyl isothiocyanate	36-56	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	22-27
29111112-4	2018	Microinjection of the TRPA1 agonist allyl isothiocyanate (AITC) onto the dura mater produced migraine-like pain for 3h as measured by depression of home cage wheel running.	allyl isothiocyanate	58-62	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	22-27
28501931-5	2018	RESULTS: Administration of AITC (20 mg/kg bw) to carcinogen-injected rats significantly decreased the expression of NF-kappaB p65, TNF-alpha, and IL-6 in mammary tissues.	allyl isothiocyanate	27-31	tumor necrosis factor	Rattus norvegicus	131-140
28501931-5	2018	RESULTS: Administration of AITC (20 mg/kg bw) to carcinogen-injected rats significantly decreased the expression of NF-kappaB p65, TNF-alpha, and IL-6 in mammary tissues.	allyl isothiocyanate	27-31	interleukin 6	Rattus norvegicus	146-150
30095054-0	2018	Targeted Drug Delivery Via Human Epidermal Growth Factor Receptor for Sustained Release of Allyl Isothiocyanate.	allyl isothiocyanate	91-111	epidermal growth factor receptor	Homo sapiens	33-65
30095054-1	2018	In this study, allyl-isothiocyanate (AITC)-loaded Polylactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) were prepared for targeting epithelial squamous carcinoma cells using a specific antibody targeting the Epidermal Growth Factor (EGF) receptor overexpressed on the cell membranes.	allyl isothiocyanate	15-35	epidermal growth factor receptor	Homo sapiens	209-247
30095054-1	2018	In this study, allyl-isothiocyanate (AITC)-loaded Polylactic-Co-Glycolic Acid (PLGA) Nanoparticles (NPs) were prepared for targeting epithelial squamous carcinoma cells using a specific antibody targeting the Epidermal Growth Factor (EGF) receptor overexpressed on the cell membranes.	allyl isothiocyanate	37-41	epidermal growth factor receptor	Homo sapiens	209-247
30095054-2	2018	AITC-loaded PLGA NPs showed more effective anticancer properties compared with free AITC, and their cytotoxicity was even more pronounced when the anti-EGFR antibody was covalently attached to the NPs surface.	allyl isothiocyanate	0-4	epidermal growth factor receptor	Homo sapiens	152-156
29037810-5	2017	OlTRPA1 showed a sensitivity to four noxious chemicals (allyl isothiocyanate, caffeine, carvacrol, methyl anthranilate).	allyl isothiocyanate	56-76	transient receptor potential cation channel subfamily A member 1	Oryzias latipes	0-7
28585088-0	2018	Allyl isothiocyanate, a potent chemopreventive agent targets AhR/Nrf2 signaling pathway in chemically induced mammary carcinogenesis.	allyl isothiocyanate	0-20	aryl hydrocarbon receptor	Rattus norvegicus	61-64
28585088-0	2018	Allyl isothiocyanate, a potent chemopreventive agent targets AhR/Nrf2 signaling pathway in chemically induced mammary carcinogenesis.	allyl isothiocyanate	0-20	NFE2 like bZIP transcription factor 2	Rattus norvegicus	65-69
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	allyl isothiocyanate	24-28	aryl hydrocarbon receptor	Rattus norvegicus	34-37
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	allyl isothiocyanate	24-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	42-46
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	allyl isothiocyanate	24-28	aryl hydrocarbon receptor	Rattus norvegicus	131-134
28585088-7	2018	The binding efficacy of AITC with AhR and Nrf2 analysis by molecular docking studies reveals that AITC has strong interaction with AhR and Nrf2 proteins through hydrogen and hydrophobic interactions.	allyl isothiocyanate	24-28	NFE2 like bZIP transcription factor 2	Rattus norvegicus	139-143
29968518-7	2018	Consistent with these results, the nocifensive behaviors evoked by an intraplantar injection of the TRPA1 agonist allyl isothiocyanate (AITC) were enhanced two weeks after the streptozotocin administration.	allyl isothiocyanate	114-134	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	100-105
29968518-7	2018	Consistent with these results, the nocifensive behaviors evoked by an intraplantar injection of the TRPA1 agonist allyl isothiocyanate (AITC) were enhanced two weeks after the streptozotocin administration.	allyl isothiocyanate	136-140	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	100-105
28614189-1	2017	Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation.	allyl isothiocyanate	72-92	transient receptor potential cation channel subfamily A member 1	Homo sapiens	58-63
28620120-3	2017	Allyl isothiocyanate (AITC), the common agonist used to identify TRPA1, contains an electrophilic group that covalently binds with cysteine residues of TRPA1 and confers a structural change on the channel.	allyl isothiocyanate	0-20	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	65-70
28620120-3	2017	Allyl isothiocyanate (AITC), the common agonist used to identify TRPA1, contains an electrophilic group that covalently binds with cysteine residues of TRPA1 and confers a structural change on the channel.	allyl isothiocyanate	0-20	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	152-157
28620120-3	2017	Allyl isothiocyanate (AITC), the common agonist used to identify TRPA1, contains an electrophilic group that covalently binds with cysteine residues of TRPA1 and confers a structural change on the channel.	allyl isothiocyanate	22-26	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	65-70
28620120-3	2017	Allyl isothiocyanate (AITC), the common agonist used to identify TRPA1, contains an electrophilic group that covalently binds with cysteine residues of TRPA1 and confers a structural change on the channel.	allyl isothiocyanate	22-26	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	152-157
28614189-1	2017	Despite being a ubiquitous animal pain model, the natural TRPA1-agonist allyl isothiocyanate (AITC, also known as "mustard oil") has only been sparsely investigated as a potential human surrogate model of pain, sensitization, and neurogenic inflammation.	allyl isothiocyanate	94-98	transient receptor potential cation channel subfamily A member 1	Homo sapiens	58-63
28571526-4	2017	Cultured HGFs responded with intracellular calcium elevations to phenytoin and to the canonical TRPA1 agonist allyl isothiocyanate.	allyl isothiocyanate	110-130	transient receptor potential cation channel subfamily A member 1	Homo sapiens	96-101
28576617-2	2017	Most acted as activators and desensitizers of TRPA1 channels like resveratrol or allyl isothiocyanate (AITC).	allyl isothiocyanate	81-101	transient receptor potential cation channel subfamily A member 1	Homo sapiens	46-51
28576617-2	2017	Most acted as activators and desensitizers of TRPA1 channels like resveratrol or allyl isothiocyanate (AITC).	allyl isothiocyanate	103-107	transient receptor potential cation channel subfamily A member 1	Homo sapiens	46-51
28702801-5	2017	The aim of our study was to investigate if crude extracts (CEs) obtained from Anisakis larvae marinated in a solution with added allyl isothiocyanate (ACE-AITC) and frozen, or from frozen only Anisakis larvae (ACE), can induce an inflammatory effect on in vitro differentiated colonic Caco-2 cells exposed or not to LPS.	allyl isothiocyanate	129-149	angiotensin I converting enzyme	Homo sapiens	151-154
28629997-5	2017	Treatment with IL-1alpha, but not IL-1beta or TNFalpha, increased the number of cells responding to allyl isothiocyanate, a TRPA1 agonist, in a dose- and time-dependent manner.	allyl isothiocyanate	100-120	interleukin 1 alpha	Homo sapiens	15-24
28629997-5	2017	Treatment with IL-1alpha, but not IL-1beta or TNFalpha, increased the number of cells responding to allyl isothiocyanate, a TRPA1 agonist, in a dose- and time-dependent manner.	allyl isothiocyanate	100-120	transient receptor potential cation channel subfamily A member 1	Homo sapiens	124-129
28408328-4	2017	However, relatively few TRPA1-expressing neurons (e.g., responsive to allyl isothiocyanate or AITC, a selective TRPA1 agonist) respond overtly to cold temperature in vitro, unlike TRPM8-expressing neurons, which almost all respond to cold.	allyl isothiocyanate	70-90	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	24-29
28515697-5	2017	TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively.	allyl isothiocyanate	91-111	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
28515697-5	2017	TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively.	allyl isothiocyanate	91-111	transient receptor potential cation channel subfamily A member 1	Homo sapiens	10-15
27904941-3	2017	METHODS AND RESULTS: The subcutaneous injection of the TRPA1 agonist allyl isothiocyanate (AITC) into the rat"s hind paw induced a dose-dependent and short lasting behavioral nociceptive response that was blocked by the co-administration of the TRPA1 antagonist, HC030031, or by the pretreatment with antisense ODN against TRPA1.	allyl isothiocyanate	69-89	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	55-60
28515697-5	2017	TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively.	allyl isothiocyanate	113-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
28515697-5	2017	TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively.	allyl isothiocyanate	113-117	transient receptor potential cation channel subfamily A member 1	Homo sapiens	10-15
28515697-5	2017	TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively.	allyl isothiocyanate	113-117	transient receptor potential cation channel subfamily A member 1	Homo sapiens	131-136
28370084-4	2017	We further revealed that the transient receptor potential ankyrin subtype 1 protein (TRPA1) protein level is upregulated and the TRPA1 activator allyl isothiocyanate induced larger ion currents in the dorsal root ganglion neurons from the docetaxel treated rats.	allyl isothiocyanate	145-165	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	29-83
28370084-4	2017	We further revealed that the transient receptor potential ankyrin subtype 1 protein (TRPA1) protein level is upregulated and the TRPA1 activator allyl isothiocyanate induced larger ion currents in the dorsal root ganglion neurons from the docetaxel treated rats.	allyl isothiocyanate	145-165	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	85-90
28370084-4	2017	We further revealed that the transient receptor potential ankyrin subtype 1 protein (TRPA1) protein level is upregulated and the TRPA1 activator allyl isothiocyanate induced larger ion currents in the dorsal root ganglion neurons from the docetaxel treated rats.	allyl isothiocyanate	145-165	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	129-134
27904941-3	2017	METHODS AND RESULTS: The subcutaneous injection of the TRPA1 agonist allyl isothiocyanate (AITC) into the rat"s hind paw induced a dose-dependent and short lasting behavioral nociceptive response that was blocked by the co-administration of the TRPA1 antagonist, HC030031, or by the pretreatment with antisense ODN against TRPA1.	allyl isothiocyanate	69-89	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	245-250
27904941-3	2017	METHODS AND RESULTS: The subcutaneous injection of the TRPA1 agonist allyl isothiocyanate (AITC) into the rat"s hind paw induced a dose-dependent and short lasting behavioral nociceptive response that was blocked by the co-administration of the TRPA1 antagonist, HC030031, or by the pretreatment with antisense ODN against TRPA1.	allyl isothiocyanate	69-89	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	245-250
27904941-3	2017	METHODS AND RESULTS: The subcutaneous injection of the TRPA1 agonist allyl isothiocyanate (AITC) into the rat"s hind paw induced a dose-dependent and short lasting behavioral nociceptive response that was blocked by the co-administration of the TRPA1 antagonist, HC030031, or by the pretreatment with antisense ODN against TRPA1.	allyl isothiocyanate	91-95	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	55-60
27904941-3	2017	METHODS AND RESULTS: The subcutaneous injection of the TRPA1 agonist allyl isothiocyanate (AITC) into the rat"s hind paw induced a dose-dependent and short lasting behavioral nociceptive response that was blocked by the co-administration of the TRPA1 antagonist, HC030031, or by the pretreatment with antisense ODN against TRPA1.	allyl isothiocyanate	91-95	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	245-250
27904941-3	2017	METHODS AND RESULTS: The subcutaneous injection of the TRPA1 agonist allyl isothiocyanate (AITC) into the rat"s hind paw induced a dose-dependent and short lasting behavioral nociceptive response that was blocked by the co-administration of the TRPA1 antagonist, HC030031, or by the pretreatment with antisense ODN against TRPA1.	allyl isothiocyanate	91-95	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	245-250
27759880-5	2017	KEY RESULTS: Phalpha1beta selectively inhibited calcium responses and currents evoked by the TRPA1 agonist, allyl isothiocyanate (AITC), on hTRPA1-HEK293, IMR90 fibroblasts and DRG neurons.	allyl isothiocyanate	108-128	transient receptor potential cation channel subfamily A member 1	Homo sapiens	93-98
28077580-3	2017	A novel peptide producing a significant potentiating effect on allyl isothiocyanate- and diclofenac-induced currents of TRPA1 was isolated from the venom of sea anemone Metridium senile.	allyl isothiocyanate	63-83	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	120-125
28077580-7	2017	Intravenous injection of Ms 9a-1 (0.3 mg/kg) produced a significant decrease in the nociceptive and inflammatory response to allyl isothiocyanate (the agonist of TRPA1) and reversed CFA (Complete Freund"s Adjuvant)-induced inflammation and thermal hyperalgesia.	allyl isothiocyanate	125-145	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	162-167
26979077-6	2017	Oral treatment with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate (AITC)) suppressed food intake in mice, and the agonist"s effects were suppressed by pretreatment with corresponding antagonists NPS-2143 or ruthenium red (RR), respectively.	allyl isothiocyanate	66-86	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	59-64
26979077-6	2017	Oral treatment with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate (AITC)) suppressed food intake in mice, and the agonist"s effects were suppressed by pretreatment with corresponding antagonists NPS-2143 or ruthenium red (RR), respectively.	allyl isothiocyanate	88-92	calcium-sensing receptor	Mus musculus	43-47
26979077-6	2017	Oral treatment with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate (AITC)) suppressed food intake in mice, and the agonist"s effects were suppressed by pretreatment with corresponding antagonists NPS-2143 or ruthenium red (RR), respectively.	allyl isothiocyanate	88-92	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	59-64
28637949-0	2017	Comparative analysis of allyl isothiocyanate (AITC)-induced carbohydrate oxidation changes via TRPV1 between mice and chickens.	allyl isothiocyanate	24-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
28637949-0	2017	Comparative analysis of allyl isothiocyanate (AITC)-induced carbohydrate oxidation changes via TRPV1 between mice and chickens.	allyl isothiocyanate	46-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
28637949-2	2017	It has been reported that intragastric administration of allyl isothiocyanate (AITC), which is one of the pungent ingredients of wasabi and horseradish but it is not included in hot chili pepper, increased carbohydrate oxidation and reduced postprandial increase of blood glucose via transient receptor potential vanilloid 1 (TRPV1)in mice.	allyl isothiocyanate	57-77	transient receptor potential cation channel subfamily V member 1	Gallus gallus	326-331
28637949-2	2017	It has been reported that intragastric administration of allyl isothiocyanate (AITC), which is one of the pungent ingredients of wasabi and horseradish but it is not included in hot chili pepper, increased carbohydrate oxidation and reduced postprandial increase of blood glucose via transient receptor potential vanilloid 1 (TRPV1)in mice.	allyl isothiocyanate	79-83	transient receptor potential cation channel subfamily V member 1	Gallus gallus	326-331
28637949-6	2017	Moreover, AITC-induced activation of mouse TRPV1 (mTRPV1) is largely dependent on S513, a residue that is involved in capsaicin-binding.	allyl isothiocyanate	10-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
28637949-6	2017	Moreover, AITC-induced activation of mouse TRPV1 (mTRPV1) is largely dependent on S513, a residue that is involved in capsaicin-binding.	allyl isothiocyanate	10-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	50-56
28637949-7	2017	Thus, we hypothesized that the increase of carbohydrate oxidation by AITC in mammals is induced by the binding of AITC to the capsaicin-binding site of TRPV1.	allyl isothiocyanate	69-73	transient receptor potential cation channel subfamily V member 1	Gallus gallus	152-157
28637949-7	2017	Thus, we hypothesized that the increase of carbohydrate oxidation by AITC in mammals is induced by the binding of AITC to the capsaicin-binding site of TRPV1.	allyl isothiocyanate	114-118	transient receptor potential cation channel subfamily V member 1	Gallus gallus	152-157
27759880-5	2017	KEY RESULTS: Phalpha1beta selectively inhibited calcium responses and currents evoked by the TRPA1 agonist, allyl isothiocyanate (AITC), on hTRPA1-HEK293, IMR90 fibroblasts and DRG neurons.	allyl isothiocyanate	108-128	transient receptor potential cation channel subfamily A member 1	Homo sapiens	140-146
27759880-5	2017	KEY RESULTS: Phalpha1beta selectively inhibited calcium responses and currents evoked by the TRPA1 agonist, allyl isothiocyanate (AITC), on hTRPA1-HEK293, IMR90 fibroblasts and DRG neurons.	allyl isothiocyanate	130-134	transient receptor potential cation channel subfamily A member 1	Homo sapiens	93-98
27759880-5	2017	KEY RESULTS: Phalpha1beta selectively inhibited calcium responses and currents evoked by the TRPA1 agonist, allyl isothiocyanate (AITC), on hTRPA1-HEK293, IMR90 fibroblasts and DRG neurons.	allyl isothiocyanate	130-134	transient receptor potential cation channel subfamily A member 1	Homo sapiens	140-146
28039411-5	2016	A vapor of one of the TRPA1-agonists, allyl isothiocyanate (AITC), was introduced by placing a piece of cotton paper soaked with AITC solution into the airline.	allyl isothiocyanate	38-58	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	22-27
27667315-7	2017	Oral gavage with selective agonists for CaSR (R-568) or TRPA1 (allyl isothiocyanate; AITC) rapidly elicited emesis in the mink in dose-dependent fashion.	allyl isothiocyanate	63-83	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	56-61
28039411-5	2016	A vapor of one of the TRPA1-agonists, allyl isothiocyanate (AITC), was introduced by placing a piece of cotton paper soaked with AITC solution into the airline.	allyl isothiocyanate	60-64	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	22-27
27899696-2	2016	Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and rodents, and TRPA1 antagonists have been reported to be effective in rodent models of pain.	allyl isothiocyanate	60-80	transient receptor potential cation channel subfamily A member 1	Homo sapiens	12-17
27899696-2	2016	Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and rodents, and TRPA1 antagonists have been reported to be effective in rodent models of pain.	allyl isothiocyanate	60-80	transient receptor potential cation channel subfamily A member 1	Homo sapiens	154-159
27899696-2	2016	Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and rodents, and TRPA1 antagonists have been reported to be effective in rodent models of pain.	allyl isothiocyanate	82-86	transient receptor potential cation channel subfamily A member 1	Homo sapiens	12-17
27899696-2	2016	Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and rodents, and TRPA1 antagonists have been reported to be effective in rodent models of pain.	allyl isothiocyanate	82-86	transient receptor potential cation channel subfamily A member 1	Homo sapiens	154-159
27899696-5	2016	In vivo target coverage of TRPA1 by AMG0902 was demonstrated by the prevention of AITC-induced flinching/licking in rats.	allyl isothiocyanate	82-86	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	27-32
27834342-0	2016	Allyl Isothiocyanate Inhibits the Proliferation of Renal Carcinoma Cell Line GRC-1 by Inducing an Imbalance Between Bcl2 and Bax.	allyl isothiocyanate	0-20	BCL2 apoptosis regulator	Homo sapiens	116-120
27834342-0	2016	Allyl Isothiocyanate Inhibits the Proliferation of Renal Carcinoma Cell Line GRC-1 by Inducing an Imbalance Between Bcl2 and Bax.	allyl isothiocyanate	0-20	BCL2 associated X, apoptosis regulator	Homo sapiens	125-128
27735854-2	2016	Components of food that stimulate TRPA1 receptors (phytonutrients) include allyl isothiocyanate, cinnamaldehyde and linalool, but these may also act at other receptors.	allyl isothiocyanate	75-95	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	34-39
27799370-2	2016	In this study, we show that TRPA1 (activated by allyl isothiocyanate, acrolein, and 4-hydroxynonenal) elevates the intracellular Ca2+ concentration ([Ca2+]i) in dorsal root ganglion (DRG) neurons in the presence and absence of extracellular Ca2+ Pharmacological and immunocytochemical analyses revealed the presence of TRPA1 channels both on the plasma membrane and in endolysosomes.	allyl isothiocyanate	48-68	transient receptor potential cation channel subfamily A member 1	Homo sapiens	28-33
27799370-2	2016	In this study, we show that TRPA1 (activated by allyl isothiocyanate, acrolein, and 4-hydroxynonenal) elevates the intracellular Ca2+ concentration ([Ca2+]i) in dorsal root ganglion (DRG) neurons in the presence and absence of extracellular Ca2+ Pharmacological and immunocytochemical analyses revealed the presence of TRPA1 channels both on the plasma membrane and in endolysosomes.	allyl isothiocyanate	48-68	transient receptor potential cation channel subfamily A member 1	Homo sapiens	319-324
26928772-0	2016	The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis.	allyl isothiocyanate	20-40	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-9
26928772-0	2016	The TRPA1 Activator Allyl Isothiocyanate (AITC) Contracts Human Jejunal Muscle: Pharmacological Analysis.	allyl isothiocyanate	42-46	transient receptor potential cation channel subfamily A member 1	Homo sapiens	4-9
26928772-1	2016	The contractile effect of AITC (300 muM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization.	allyl isothiocyanate	26-30	latexin	Homo sapiens	36-39
26928772-1	2016	The contractile effect of AITC (300 muM) on human jejunal longitudinal strips was inhibited by the TRPA1 antagonist HC 030031 and atropine or scopolamine, but was insensitive to tetrodotoxin, purinoceptor antagonists or capsaicin desensitization.	allyl isothiocyanate	26-30	transient receptor potential cation channel subfamily A member 1	Homo sapiens	99-104
27241356-1	2016	We evaluated the hepatoprotective activity of allyl isothiocyanate (AITC) against carbon tetrachloride (CCl4)-induced liver injury in rats.	allyl isothiocyanate	46-66	C-C motif chemokine ligand 4	Rattus norvegicus	104-108
27241356-1	2016	We evaluated the hepatoprotective activity of allyl isothiocyanate (AITC) against carbon tetrachloride (CCl4)-induced liver injury in rats.	allyl isothiocyanate	68-72	C-C motif chemokine ligand 4	Rattus norvegicus	104-108
27449282-2	2016	Here we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammalian cold sensor TRPM8.	allyl isothiocyanate	18-22	transient receptor potential cation channel subfamily M member 8	Homo sapiens	140-145
27449282-2	2016	Here we show that AITC (allyl isothiocyanate; mustard oil) and menthol represent two distinct types of ligands at the mammalian cold sensor TRPM8.	allyl isothiocyanate	24-44	transient receptor potential cation channel subfamily M member 8	Homo sapiens	140-145
27423812-7	2016	Prior application of MG evoked reciprocal suppression of subsequent [Ca(2+)]i responses to allylisothiocyanate, a TRPA1 agonist, and vice versa.	allyl isothiocyanate	91-110	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	114-119
27345869-2	2016	An important locus for TRPA1 regulation is the cytoplasmic N-terminal domain, through which various exogenous electrophilic compounds such as allyl-isothiocyanate from mustard oil or cinnamaldehyde from cinnamon activate primary afferent nociceptors.	allyl isothiocyanate	142-162	transient receptor potential cation channel subfamily A member 1	Homo sapiens	23-28
27126699-1	2016	AIMS: To investigate the roles of TRPV1 and TRPA1 channels in baseline and allyl isothiocyanate (AITC)-evoked nociceptive responses by comparing wild-type and gene-deficient mice.	allyl isothiocyanate	75-95	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	34-39
26930003-5	2016	Calcium influx in response to the TRPA1 agonist allyl-isothiocyanate (AITC) (200 muM) and the TRPV1 stimulator capsaicin (330 nM) in rat trigeminal neurons or TRPA1 and TRPV1 receptor-expressing cell lines was measured by microfluorimetry or radioactive (45)Ca(2+) uptake experiments.	allyl isothiocyanate	48-68	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	34-39
26930003-5	2016	Calcium influx in response to the TRPA1 agonist allyl-isothiocyanate (AITC) (200 muM) and the TRPV1 stimulator capsaicin (330 nM) in rat trigeminal neurons or TRPA1 and TRPV1 receptor-expressing cell lines was measured by microfluorimetry or radioactive (45)Ca(2+) uptake experiments.	allyl isothiocyanate	70-74	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	34-39
26930003-6	2016	Calcitonin gene-related peptide (CGRP) release as the indicator of 100 muM AITC - or 100 nM capsaicin-induced peripheral sensory nerve terminal activation was measured by radioimmunoassay.	allyl isothiocyanate	75-79	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
26930003-6	2016	Calcitonin gene-related peptide (CGRP) release as the indicator of 100 muM AITC - or 100 nM capsaicin-induced peripheral sensory nerve terminal activation was measured by radioimmunoassay.	allyl isothiocyanate	75-79	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
27241356-6	2016	In serum chemistry, the oral administration of AITC itself did not affect the serum levels of ALT or AST, furthermore pretreatment with AITC 5 and AITC 50 significantly reduced the ALT and AST activity levels that were elevated in CCl4-intoxicated rats.	allyl isothiocyanate	136-140	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	189-192
27241356-6	2016	In serum chemistry, the oral administration of AITC itself did not affect the serum levels of ALT or AST, furthermore pretreatment with AITC 5 and AITC 50 significantly reduced the ALT and AST activity levels that were elevated in CCl4-intoxicated rats.	allyl isothiocyanate	136-140	C-C motif chemokine ligand 4	Rattus norvegicus	231-235
27241356-8	2016	The histopathological evaluation and Iba-1 immunoreactivity also supported the hepatoprotective effects of AITC against CCl4-induced liver injury.	allyl isothiocyanate	107-111	allograft inflammatory factor 1	Rattus norvegicus	37-42
27241356-8	2016	The histopathological evaluation and Iba-1 immunoreactivity also supported the hepatoprotective effects of AITC against CCl4-induced liver injury.	allyl isothiocyanate	107-111	C-C motif chemokine ligand 4	Rattus norvegicus	120-124
26521174-5	2016	Herein, we report that bilateral intra-CeA microinjection of a selective GABAA receptor agonist muscimol hydrochloride (Mus; 50 ng per side), but not a selective GABAA receptor antagonist bicuculline (Bic; 20 ng per side) or vehicle, showed significant analgesic effects, reflected by an increase in tail-flick latency and a decrease in allyl isothiocyanate (mustard oil)-evoked ipsilateral forelimb wipes.	allyl isothiocyanate	337-357	carcinoembryonic antigen gene family 4	Rattus norvegicus	39-42
27064319-7	2016	Whole-cell recording was performed to record TRPV1-mediated membrane current; TRPV1 current density significantly increased in the AITC-sensitive neurons after the quisqualate treatment.	allyl isothiocyanate	131-135	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-50
27064319-7	2016	Whole-cell recording was performed to record TRPV1-mediated membrane current; TRPV1 current density significantly increased in the AITC-sensitive neurons after the quisqualate treatment.	allyl isothiocyanate	131-135	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
26634370-5	2016	Further experiments showed that cold-sensing transient receptor potential subfamily member 1 (TRPA1) agonist (allyl isothiocyanate, AITC) increased the production of ROS and the level of [Ca(2+)]c in A549 cell.	allyl isothiocyanate	110-130	transient receptor potential cation channel subfamily A member 1	Homo sapiens	94-99
26274042-5	2016	The results obtained indicate that TRPA1 and TRPV1 channels are clearly involved in pain reactions, and the TRPA1 agonist allyl isothiocyanate enhances the heat pain sensitivity, possibly by indirectly modulating TRPV1 channels coexpressed in nociceptors with TRPA1.	allyl isothiocyanate	122-142	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	108-113
26274042-5	2016	The results obtained indicate that TRPA1 and TRPV1 channels are clearly involved in pain reactions, and the TRPA1 agonist allyl isothiocyanate enhances the heat pain sensitivity, possibly by indirectly modulating TRPV1 channels coexpressed in nociceptors with TRPA1.	allyl isothiocyanate	122-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	213-218
26274042-5	2016	The results obtained indicate that TRPA1 and TRPV1 channels are clearly involved in pain reactions, and the TRPA1 agonist allyl isothiocyanate enhances the heat pain sensitivity, possibly by indirectly modulating TRPV1 channels coexpressed in nociceptors with TRPA1.	allyl isothiocyanate	122-142	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	108-113
27313495-6	2016	Treatment with allyl isothiocyanate (AITC, a TRPA1 agonist) retarded the progression of atherosclerosis in apoE(-/-) mice but not apoE(-/-)TRPA1(-/-) mice.	allyl isothiocyanate	15-35	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	45-50
27313495-6	2016	Treatment with allyl isothiocyanate (AITC, a TRPA1 agonist) retarded the progression of atherosclerosis in apoE(-/-) mice but not apoE(-/-)TRPA1(-/-) mice.	allyl isothiocyanate	37-41	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	45-50
26690132-0	2015	Allyl Isothiocyanate Inhibits Actin-Dependent Intracellular Transport in Arabidopsis thaliana.	allyl isothiocyanate	0-20	actin-12	Arabidopsis thaliana	30-35
27080949-8	2016	AITC induced apoptosis in human breast cancer MCF-7 cells via AIF and Endo G signaling pathways, but in MDA-MB-231 cells apoptosis occurred via the GADD153 pathway.	allyl isothiocyanate	0-4	apoptosis inducing factor mitochondria associated 1	Homo sapiens	62-65
27080949-8	2016	AITC induced apoptosis in human breast cancer MCF-7 cells via AIF and Endo G signaling pathways, but in MDA-MB-231 cells apoptosis occurred via the GADD153 pathway.	allyl isothiocyanate	0-4	endonuclease G	Homo sapiens	70-76
27336729-1	2016	BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT), originating from the enterochromaffin cells has been reported to mediate the contractile effect of the sensory stimulant and TRPA1 activator allyl isothiocyanate (AITC) in the guinea-pig small intestine [Nozawa et al: Proc Natl Acad Sci U S A 2009;106:3408-3413].	allyl isothiocyanate	192-212	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	176-181
27336729-1	2016	BACKGROUND: Serotonin (5-hydroxytryptamine, 5-HT), originating from the enterochromaffin cells has been reported to mediate the contractile effect of the sensory stimulant and TRPA1 activator allyl isothiocyanate (AITC) in the guinea-pig small intestine [Nozawa et al: Proc Natl Acad Sci U S A 2009;106:3408-3413].	allyl isothiocyanate	214-218	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	176-181
26690132-3	2015	In this study, we present evidence of an AITC-induced inhibition of actin-dependent intracellular transport in A. thaliana.	allyl isothiocyanate	41-45	actin-12	Arabidopsis thaliana	68-73
26690132-7	2015	Furthermore, the morphologies of actin filaments, ER and vacuoles appeared aberrant following AITC-exposure.	allyl isothiocyanate	94-98	actin-12	Arabidopsis thaliana	33-38
26690132-8	2015	However, AITC-treated seedlings of all transgenic lines tested displayed morphologies and intracellular movements similar to that of the corresponding untreated and control-treated plants, following overnight incubation in an AITC-absent environment, indicating that AITC-induced decline in actin-related movements is a reversible process.	allyl isothiocyanate	9-13	actin-12	Arabidopsis thaliana	291-296
26351757-6	2015	The results obtained indicated that the sensitivity of pfTRPA1 to known TRPA1 ligands was lower than that of mammalian TRPA1s, except for the response ability to allyl isothiocyanate.	allyl isothiocyanate	162-182	transient receptor potential cation channel subfamily A member 1	Homo sapiens	57-62
26338358-3	2015	Rate constants for the inactivation of PTP1B and SHP-2 by allyl isothiocyanate and sulforaphane range from 2 to 16 M(-1)s(-1).	allyl isothiocyanate	58-78	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	39-44
26338358-3	2015	Rate constants for the inactivation of PTP1B and SHP-2 by allyl isothiocyanate and sulforaphane range from 2 to 16 M(-1)s(-1).	allyl isothiocyanate	58-78	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	49-54