PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 18363352-2 2008 We report here the identification of a novel class of azetidinone CB1 antagonists by using virtual screening methods. 2-azetidinone 54-65 cannabinoid receptor 1 Homo sapiens 66-69 20970895-4 2010 Subsequently 2-azetidinones were highlighted as a potent mechanism based inhibitor of several enzymes like human tryptase, chymase, thrombin, leukocyte elastase, human cytomegalovirus protease and serine protease enzyme. 2-azetidinone 13-27 chymase 1 Homo sapiens 123-130 20970895-4 2010 Subsequently 2-azetidinones were highlighted as a potent mechanism based inhibitor of several enzymes like human tryptase, chymase, thrombin, leukocyte elastase, human cytomegalovirus protease and serine protease enzyme. 2-azetidinone 13-27 coagulation factor II, thrombin Homo sapiens 132-140 20970895-4 2010 Subsequently 2-azetidinones were highlighted as a potent mechanism based inhibitor of several enzymes like human tryptase, chymase, thrombin, leukocyte elastase, human cytomegalovirus protease and serine protease enzyme. 2-azetidinone 13-27 elastase, neutrophil expressed Homo sapiens 142-160 20580233-1 2010 A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. 2-azetidinone 33-45 calcium voltage-gated channel subunit alpha1 H Homo sapiens 113-122 19821480-0 2009 Azetidinones as zinc-binding groups to design selective HDAC8 inhibitors. 2-azetidinone 0-12 histone deacetylase 8 Homo sapiens 56-61 18547805-1 2008 A series of novel 2-azetidinones (beta-lactams) bearing short alkenyl chains at C3 and N1 have been prepared and evaluated in vitro as inhibitors of human FAAH. 2-azetidinone 18-32 fatty acid amide hydrolase Homo sapiens 155-159 21080725-0 2010 Synthesis and evaluation of azetidinone analogues of combretastatin A-4 as tubulin targeting agents. 2-azetidinone 28-39 immunoglobulin kappa variable 1D-27 (pseudogene) Homo sapiens 68-71 19916530-1 2009 The beta-stabilizing effect of silicon substituent at C-3 on a C-4 cation and a radical in the 2-azetidinone systems is studied using NMR kinetics. 2-azetidinone 95-108 complement C3 Homo sapiens 54-57 19916530-1 2009 The beta-stabilizing effect of silicon substituent at C-3 on a C-4 cation and a radical in the 2-azetidinone systems is studied using NMR kinetics. 2-azetidinone 95-108 complement C4A (Rodgers blood group) Homo sapiens 63-66 19038477-0 2009 Large ring 1,3-bridged 2-azetidinones: experimental and theoretical studies. 2-azetidinone 23-37 ring finger protein 1 Homo sapiens 6-12 19038477-2 2009 Our study deals with original 13-membered-ring 1,3-bridged 2-azetidinones related to the carbapenem family, and featuring a "planar amide" instead of the "twisted amide" typical of penam derivatives. 2-azetidinone 59-73 ring finger protein 1 Homo sapiens 42-48 11814785-3 2002 They are structurally consistent with the allowable SAR of the 2-azetidinone class of cholesterol absorption inhibitors. 2-azetidinone 63-76 sarcosine dehydrogenase Homo sapiens 52-55 17234419-1 2007 The azetidinone LY307174 (1) was identified as a screening lead for the vasopressin V1a receptor (IC50 45 nM at the human V1a receptor) based on molecular similarity to ketoconazole (2), a known antagonist of the luteinizing hormone releasing hormone receptor. 2-azetidinone 4-15 arginine vasopressin receptor 1A Homo sapiens 72-96 17456042-5 2007 The lead molecules characterized as PLA2 inhibitors are indoles, azetidinones, piperazines, isoxazolidines, isoxazolines, diazepinones, acenaphthenes and several substrate analogues. 2-azetidinone 65-77 phospholipase A2 group IB Homo sapiens 36-40 15104463-2 2004 The azetidinone ring of compounds 7 is formed by C-3/C-4 cyclization of (2R,3R)-epoxybutyramide precursors 6, N-protected with a benzhydryl group. 2-azetidinone 4-15 complement C3 Homo sapiens 49-52 15104463-2 2004 The azetidinone ring of compounds 7 is formed by C-3/C-4 cyclization of (2R,3R)-epoxybutyramide precursors 6, N-protected with a benzhydryl group. 2-azetidinone 4-15 complement C4A (Rodgers blood group) Homo sapiens 53-56 15081015-0 2004 Solid-phase synthesis and SAR of 4-carboxy-2-azetidinone mechanism-based tryptase inhibitors. 2-azetidinone 33-56 sarcosine dehydrogenase Homo sapiens 26-29 11937339-2 2002 The synthesis relies on two completely stereoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. 2-azetidinone 136-147 complement C3 Homo sapiens 117-120 11937339-2 2002 The synthesis relies on two completely stereoselective reactions that allow the introduction of the stereocenters at C-3 and C-4 of the azetidinone ring in a predictable manner. 2-azetidinone 136-147 complement C4A (Rodgers blood group) Homo sapiens 125-128 11334560-0 2001 Design, synthesis, and proposed active site binding analysis of monocyclic 2-azetidinone inhibitors of prostate specific antigen. 2-azetidinone 75-88 kallikrein related peptidase 3 Homo sapiens 103-128 10823683-1 2000 We have examined the in vivo anti-inflammatory and analgesic activity of a new series of monocyclic beta-lactams (azetidinones), similar to others which have been demonstrated to be inhibitors of human leukocyte elastase (HLE), an enzyme involved in degradation processes of connective tissue. 2-azetidinone 114-126 elastase, neutrophil expressed Homo sapiens 222-225 24142910-1 2013 In an effort to develop new molecules with improved antihyperlipidemic activity, eight new 2-azetidinone analogs (4a-4h) of ezetimibe were designed through in silico docking experiments with the crystal structure of the Niemann-Pick C1-like 1 protein (NPC1L1). 2-azetidinone 91-104 NPC1 like intracellular cholesterol transporter 1 Rattus norvegicus 220-250 23564200-1 2013 In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (beta-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. 2-azetidinone 75-86 carbonic anhydrase 4 Homo sapiens 69-73 23564200-1 2013 In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (beta-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. 2-azetidinone 75-86 carbonic anhydrase 4 Homo sapiens 224-228 23186023-9 2013 Multiple sites for the AZD and NHS linkers have been easily identified and confirmed by MS2 sequencing. 2-azetidinone 23-26 MS2 Homo sapiens 88-91 11327591-1 2001 A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme. 2-azetidinone 73-87 complement C4A (Rodgers blood group) Homo sapiens 155-158 31954879-1 2020 A series of novel 1,4-diaryl-2-azetidinone analogues of combretastatin A-4 (CA-4) have been designed, synthesised and evaluated in vitro for antiproliferative activity, antiapoptotic activity and inhibition of tubulin polymerisation. 2-azetidinone 18-42 carbonic anhydrase 4 Homo sapiens 76-80