PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
22228626-5	2012	Secondary activation of P2X1-dependent Ca(2+) influx also persisted in the presence of nitric oxide, delivered from spermine NONOate, or increased ectonucleotidase levels (apyrase).	spermine nitric oxide complex	116-132	purinergic receptor P2X 1	Homo sapiens	24-28
25062958-6	2014	eNOS activation (using adenosine, salbutamol, thrombin, or histamine), or application of an NO donor (spermine NONOate) or cGMP-analogue (8-bromo-cGMP) caused nuclear translocation of beta-catenin in HUVEC as shown by western blotting of nuclear extracts.	spermine nitric oxide complex	102-118	catenin beta 1	Homo sapiens	184-196
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	spermine nitric oxide complex	12-28	catenin beta 1	Homo sapiens	130-142
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	spermine nitric oxide complex	12-28	C-X-C motif chemokine ligand 8	Homo sapiens	166-170
25062958-7	2014	Exposure to spermine NONOate, 8-bromo-cGMP, or sildenafil (a phosphodiesterase type 5 inhibitor) also increased the expression of beta-catenin-dependent transcripts, IL-8, and cyclin D1.	spermine nitric oxide complex	12-28	cyclin D1	Homo sapiens	176-185
23882224-9	2013	Moreover, addition of a NO donor (spermine NONOate) to increase NO bioavailability abolished the contractile response from combined application of angiotensin II and adenosine.	spermine nitric oxide complex	34-50	angiotensinogen	Homo sapiens	147-161
21536853-9	2011	Administration of spermine NONOate, an NO donor compound, did not affect sarcomeric shortening in CM of either genotype; however, in the presence of isoproterenol, addition of spermine NONOate reduced sarcomere shortening in WT but not in sGCalpha(1)(-/-) CM.	spermine nitric oxide complex	176-192	guanylate cyclase 1, soluble, alpha 1	Mus musculus	239-250
22226756-4	2012	We found that (1) a high concentration of spermine NONOate (an NO donor; 500 muM) opened mPTP and depolarized DeltaPsi(m).	spermine nitric oxide complex	42-58	latexin	Homo sapiens	77-80
19687162-7	2009	Platelet P-selectin expression was higher in hypertensives than in NT, and its expression was suppressed by SNO in NT only.	spermine nitric oxide complex	108-111	selectin P	Homo sapiens	9-19
21329685-7	2011	Furthermore, the NO donor spermine NONOate was able to inhibit G6PD activity in vitro, and this effect was partly reverted by PTIO.	spermine nitric oxide complex	26-42	glucose-6-phosphate dehydrogenase	Homo sapiens	63-67
20349036-2	2010	We hypothesised that pharmacological treatment of human skeletal muscle with N-(2-aminoethyl)-N-(2-hydroxy-2-nitrosohydrazino)-1,2-ethylenediamine (spermine NONOate) would increase intracellular cyclic GMP (cGMP) levels and promote glucose transport.	spermine nitric oxide complex	148-164	5'-nucleotidase, cytosolic II	Homo sapiens	202-205
20349036-9	2010	Consistent with this, spermine NONOate increased AMP-activated protein kinase (AMPK)-alpha1-associated activity (1.7-fold, p < 0.05).	spermine nitric oxide complex	22-38	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	49-77
20349036-9	2010	Consistent with this, spermine NONOate increased AMP-activated protein kinase (AMPK)-alpha1-associated activity (1.7-fold, p < 0.05).	spermine nitric oxide complex	22-38	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	79-83
20349036-9	2010	Consistent with this, spermine NONOate increased AMP-activated protein kinase (AMPK)-alpha1-associated activity (1.7-fold, p < 0.05).	spermine nitric oxide complex	22-38	adrenoceptor alpha 1D	Homo sapiens	85-91
20349036-10	2010	In L6 muscle cells, spermine NONOate increased glucose uptake (p < 0.01) and glycogen synthesis (p < 0.001), an effect that was in addition to that of insulin.	spermine nitric oxide complex	20-36	insulin	Homo sapiens	157-164
20349036-11	2010	Spermine NONOate also elicited a concomitant increase in AMPK and acetyl-CoA carboxylase phosphorylation.	spermine nitric oxide complex	0-16	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	57-61
20349036-13	2010	CONCLUSIONS/INTERPRETATION: Pharmacological treatment of skeletal muscle with spermine NONOate increases glucose transport via insulin-independent signalling pathways involving increased intracellular cGMP levels and AMPK-alpha1-associated activity.	spermine nitric oxide complex	78-94	insulin	Homo sapiens	127-134
20349036-13	2010	CONCLUSIONS/INTERPRETATION: Pharmacological treatment of skeletal muscle with spermine NONOate increases glucose transport via insulin-independent signalling pathways involving increased intracellular cGMP levels and AMPK-alpha1-associated activity.	spermine nitric oxide complex	78-94	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	217-228
20061377-6	2010	Exposing cells to hydrogen peroxide, to the nitric oxide donor spermine NONOate, to hypochlorous acid, or to S-nitrosocysteine further increased this disulfide and promoted formation of a disulfide linking two KEAP1 molecules via Cys(151).	spermine nitric oxide complex	63-79	kelch like ECH associated protein 1	Homo sapiens	210-215
19447893-7	2009	Furthermore, in vitro, we found that exposure to the NO donor spermine NONOate (SPNONO) led to an increase in GCH1 protein and BH(4) levels in both COS-7 and pulmonary arterial endothelial cells.	spermine nitric oxide complex	62-78	GTP cyclohydrolase 1	Homo sapiens	110-114
19447893-7	2009	Furthermore, in vitro, we found that exposure to the NO donor spermine NONOate (SPNONO) led to an increase in GCH1 protein and BH(4) levels in both COS-7 and pulmonary arterial endothelial cells.	spermine nitric oxide complex	80-86	GTP cyclohydrolase 1	Homo sapiens	110-114
19447893-8	2009	However, SPNONO treatment also caused a significant increase in phospho-cAMP response element binding protein (CREB) levels, as detected by Western blot analysis, and significantly increased cAMP levels, as detected by enzyme immunoassay.	spermine nitric oxide complex	9-15	cAMP responsive element binding protein 1	Homo sapiens	64-109
19447893-8	2009	However, SPNONO treatment also caused a significant increase in phospho-cAMP response element binding protein (CREB) levels, as detected by Western blot analysis, and significantly increased cAMP levels, as detected by enzyme immunoassay.	spermine nitric oxide complex	9-15	cAMP responsive element binding protein 1	Homo sapiens	111-115
19447893-8	2009	However, SPNONO treatment also caused a significant increase in phospho-cAMP response element binding protein (CREB) levels, as detected by Western blot analysis, and significantly increased cAMP levels, as detected by enzyme immunoassay.	spermine nitric oxide complex	9-15	cathelicidin antimicrobial peptide	Homo sapiens	72-76
15772258-7	2005	The ROS scavengers prevented, and the addition of H(2)O(2) or spermine-NONOate (nitric oxide donor) triggered, the increase of phospho-MEK-like proteins.	spermine nitric oxide complex	62-78	mitogen-activated protein kinase kinase 7	Homo sapiens	135-138
19075094-7	2009	In the presence of N(G)-nitro-L-arginine methyl ester hydrochloride, the addition of exogenous NO (1 micromol/L spermine NONOate) restored the angiotensin II-induced decreases in NOS3 expression (-22+/-6%; n=7; P<0.013).	spermine nitric oxide complex	112-128	angiotensinogen	Rattus norvegicus	143-157
19075094-7	2009	In the presence of N(G)-nitro-L-arginine methyl ester hydrochloride, the addition of exogenous NO (1 micromol/L spermine NONOate) restored the angiotensin II-induced decreases in NOS3 expression (-22+/-6%; n=7; P<0.013).	spermine nitric oxide complex	112-128	nitric oxide synthase 3	Rattus norvegicus	179-183
18639532-7	2008	Additionally, NO donor spermine NONOate could inhibit the AChE activity in brain homogenates in a concentration-dependent manner, which further substantiate that nitric oxide produced during post hypoxia re-oxygenation, primarily contributes to the observed inhibition of cortical AChE activity.	spermine nitric oxide complex	23-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	58-62
18639532-7	2008	Additionally, NO donor spermine NONOate could inhibit the AChE activity in brain homogenates in a concentration-dependent manner, which further substantiate that nitric oxide produced during post hypoxia re-oxygenation, primarily contributes to the observed inhibition of cortical AChE activity.	spermine nitric oxide complex	23-39	acetylcholinesterase (Cartwright blood group)	Homo sapiens	281-285
17700714-8	2007	KEY RESULTS: Macrophages and SMCs treated with spermine NONOate or SNAP showed several signs of ER stress, including upregulation of CHOP expression, hyperphosphorylation of eIF2 alpha, inhibition of de novo protein synthesis and splicing of XBP1 mRNA.	spermine nitric oxide complex	47-63	DNA damage inducible transcript 3	Homo sapiens	133-137
17700714-8	2007	KEY RESULTS: Macrophages and SMCs treated with spermine NONOate or SNAP showed several signs of ER stress, including upregulation of CHOP expression, hyperphosphorylation of eIF2 alpha, inhibition of de novo protein synthesis and splicing of XBP1 mRNA.	spermine nitric oxide complex	47-63	eukaryotic translation initiation factor 2A	Homo sapiens	174-184
17700714-8	2007	KEY RESULTS: Macrophages and SMCs treated with spermine NONOate or SNAP showed several signs of ER stress, including upregulation of CHOP expression, hyperphosphorylation of eIF2 alpha, inhibition of de novo protein synthesis and splicing of XBP1 mRNA.	spermine nitric oxide complex	47-63	X-box binding protein 1	Homo sapiens	242-246
16424005-3	2006	Our results show that cells deficient in Rev1 and Rev3, a subunit essential for DNA polymerase zeta (Polzeta), are hypersensitive to killing by two chemical NO donors, spermine NONOate and S-nitroso-N-acetyl-penicillamine.	spermine nitric oxide complex	168-184	REV1, DNA directed polymerase	Gallus gallus	41-45
16303606-5	2005	Treatment with aminoglutethimide (blocker of cytochrome P450scc; 1.5 x 10(-4)M), nitric oxide donor (spermine NONOate), and staurosporine increased bax expression in cells collected from both experimental periods.	spermine nitric oxide complex	101-117	BCL2 associated X, apoptosis regulator	Homo sapiens	148-151
18178725-4	2008	Induction of HO-1 was associated with an attenuation of pulmonary arterial relaxation to the NO-donor spermine-NONOate.	spermine nitric oxide complex	102-118	heme oxygenase 1	Homo sapiens	13-17
18178725-8	2008	However, the increase in activity seen in the presence of 1 microM spermine-NONOate was attenuated in homogenates obtained from arteries with increased HO-1.	spermine nitric oxide complex	67-83	heme oxygenase 1	Homo sapiens	152-156
17097687-3	2007	Here, we show that the NO donor spermine/NONOate inhibited leptin-induced activation of STAT3 in vitro.	spermine nitric oxide complex	32-48	signal transducer and activator of transcription 3	Homo sapiens	88-93
15772258-8	2005	The capacitation-related increases in phospho-MEK-like proteins induced by FCSu, H(2)O(2), and spermine-NONOate were similarly modulated by PKA, PKC, and PTK, suggesting ROS as mediators in this phenomenon.	spermine nitric oxide complex	95-111	mitogen-activated protein kinase kinase 7	Homo sapiens	46-49
15772258-8	2005	The capacitation-related increases in phospho-MEK-like proteins induced by FCSu, H(2)O(2), and spermine-NONOate were similarly modulated by PKA, PKC, and PTK, suggesting ROS as mediators in this phenomenon.	spermine nitric oxide complex	95-111	protein tyrosine kinase 2 beta	Homo sapiens	154-157
15872077-3	2005	Treatment of rat mesangial cells (MC) with the NO donors diethylenetriamine NO (DETA-NO) or spermine-NONOate resulted in a time- and dose-dependent upregulation of PDGF receptor alpha (PDGFRalpha) but not PDGFRbeta mRNA levels.	spermine nitric oxide complex	92-108	platelet derived growth factor receptor alpha	Rattus norvegicus	185-195
15872077-3	2005	Treatment of rat mesangial cells (MC) with the NO donors diethylenetriamine NO (DETA-NO) or spermine-NONOate resulted in a time- and dose-dependent upregulation of PDGF receptor alpha (PDGFRalpha) but not PDGFRbeta mRNA levels.	spermine nitric oxide complex	92-108	platelet derived growth factor receptor beta	Rattus norvegicus	205-214
15879708-4	2005	When extracellular pH ([pH]o) was reduced to pH 6.4, COX-2 mRNA increased, with a peak at 2 h. This was blocked by pretreatment with actinomycin D and incubation with spermine NONOate (SPER/NO, a nitric oxide donor).	spermine nitric oxide complex	167-183	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
15740980-8	2005	When the GSH-depleted or BSO-pretreated macrophages were exposed to NO, delivered either exogenously from spermine NONOate or endogenously from LPS-derived elevation of iNOS, super-induction of HO-1 was observed.	spermine nitric oxide complex	106-122	heme oxygenase 1	Homo sapiens	194-198
15531583-4	2005	Using the NO donor spermine NONOate at pH 7.4, MPO potentiated N-NO-IQ formation.	spermine nitric oxide complex	19-35	myeloperoxidase	Homo sapiens	47-50
15740980-7	2005	Alternatively, when the macrophages were exposed to spermine NONOate, an exogenous NO-donor, HO-1, was induced also.	spermine nitric oxide complex	52-68	heme oxygenase 1	Homo sapiens	93-97
15465034-4	2004	Furthermore, spermine-NONOate, but not the cGMP analog, 8-bromo-cGMP, dose- and time-dependently attenuated FMO1 mRNA stability in actinomycin-D-pretreated cells, resulting in decreases in protein levels and biochemical activity.	spermine nitric oxide complex	13-29	flavin containing dimethylaniline monoxygenase 1	Rattus norvegicus	108-112
15310556-7	2004	We found that spermine NONOate reversed Y-27632-sensitive Ca(2+) sensitization and inhibited both RhoA and ROK activity in vessels from CH rats but not control animals.	spermine nitric oxide complex	14-30	ras homolog family member A	Rattus norvegicus	98-102
15310556-7	2004	We found that spermine NONOate reversed Y-27632-sensitive Ca(2+) sensitization and inhibited both RhoA and ROK activity in vessels from CH rats but not control animals.	spermine nitric oxide complex	14-30	Rho-associated coiled-coil containing protein kinase 2	Rattus norvegicus	107-110
15293554-4	2004	This study examined the effects of pyrrolidine dithiocarbamate (PDTC, 0.1 mM) and spermine NONOate (Sper-NO, 1 mM) on the secretion and gene expression of chemokines, interleukin (IL)-8, monocyte chemotactic protein (MCP)-1, regulated upon activation normal T cell expressed and secreted (RANTES), and eotaxin.	spermine nitric oxide complex	82-98	C-X-C motif chemokine ligand 8	Homo sapiens	167-185
15158362-1	2004	We describe the involvement of poly(ADP-ribose)polymerase 1 and 2 (PARP-1 and -2) and poly(ADP-ribose)glycohydrolase (PARG) in the response of rat germinal cells to the action of the NO donors, 3-morpholino-sydnonimine (SIN-1) and spermine nonoate (SNO).	spermine nitric oxide complex	231-247	poly (ADP-ribose) polymerase 1	Rattus norvegicus	31-65
15158362-1	2004	We describe the involvement of poly(ADP-ribose)polymerase 1 and 2 (PARP-1 and -2) and poly(ADP-ribose)glycohydrolase (PARG) in the response of rat germinal cells to the action of the NO donors, 3-morpholino-sydnonimine (SIN-1) and spermine nonoate (SNO).	spermine nitric oxide complex	231-247	poly (ADP-ribose) polymerase 1	Rattus norvegicus	67-80
15158362-1	2004	We describe the involvement of poly(ADP-ribose)polymerase 1 and 2 (PARP-1 and -2) and poly(ADP-ribose)glycohydrolase (PARG) in the response of rat germinal cells to the action of the NO donors, 3-morpholino-sydnonimine (SIN-1) and spermine nonoate (SNO).	spermine nitric oxide complex	231-247	poly (ADP-ribose) glycohydrolase	Rattus norvegicus	118-122
15158362-1	2004	We describe the involvement of poly(ADP-ribose)polymerase 1 and 2 (PARP-1 and -2) and poly(ADP-ribose)glycohydrolase (PARG) in the response of rat germinal cells to the action of the NO donors, 3-morpholino-sydnonimine (SIN-1) and spermine nonoate (SNO).	spermine nitric oxide complex	249-252	poly (ADP-ribose) polymerase 1	Rattus norvegicus	31-65
15158362-1	2004	We describe the involvement of poly(ADP-ribose)polymerase 1 and 2 (PARP-1 and -2) and poly(ADP-ribose)glycohydrolase (PARG) in the response of rat germinal cells to the action of the NO donors, 3-morpholino-sydnonimine (SIN-1) and spermine nonoate (SNO).	spermine nitric oxide complex	249-252	poly (ADP-ribose) polymerase 1	Rattus norvegicus	67-80
15158362-1	2004	We describe the involvement of poly(ADP-ribose)polymerase 1 and 2 (PARP-1 and -2) and poly(ADP-ribose)glycohydrolase (PARG) in the response of rat germinal cells to the action of the NO donors, 3-morpholino-sydnonimine (SIN-1) and spermine nonoate (SNO).	spermine nitric oxide complex	249-252	poly (ADP-ribose) glycohydrolase	Rattus norvegicus	118-122
15158362-5	2004	Consistent with the DNA repair seen in primary spermatocytes, both SIN-1 and SNO induced PARPs activation in these cells.	spermine nitric oxide complex	77-80	poly (ADP-ribose) polymerase 1	Rattus norvegicus	89-94
15158362-6	2004	In the case of SIN-1, there was an immediate but transient response while SNO induced a delayed but more sustained increase in PARPs activity.	spermine nitric oxide complex	74-77	poly (ADP-ribose) polymerase 1	Rattus norvegicus	127-132
15158362-7	2004	Chronic exposure of spermatocytes to SIN-1 and SNO, however, committed the cells to apoptosis, which coincided with proteolysis of PARP-1.	spermine nitric oxide complex	47-50	poly (ADP-ribose) polymerase 1	Rattus norvegicus	131-137
15064242-4	2004	Here we demonstrate using gelatin substrate zymography that high NO concentrations, whether produced endogenously or by NO donor spermine-NONOate or peroxynitrite-generating compound SIN-1, significantly inhibit MMP-9 expression and activation.	spermine nitric oxide complex	129-145	matrix metallopeptidase 9	Homo sapiens	212-217
15886872-10	2004	The modulation of NO did not alter HGF-induced chemoinvasion of endothelial cells, while spermine-NONOate destabilized HGF-induced tubulogenesis, suggesting that a single assay is not sufficient for predicting the final phenotypic outcome on angiogenesis.	spermine nitric oxide complex	89-105	hepatocyte growth factor	Homo sapiens	119-122
15076229-0	2004	Extracellular nitric oxide release mediates soluble guanylate cyclase-independent vasodilator action of spermine NONOate: comparison with other nitric oxide donors in isolated rat femoral arteries.	spermine nitric oxide complex	104-120	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	44-69
14668094-12	2003	CONCLUSIONS: Our data show that SIN-1 biological effect on some neutrophils activity is different from both spermine NONOate and SNP, and mainly depends on ONOO(-), while SNP action is mediated by NO.	spermine nitric oxide complex	108-124	MAPK associated protein 1	Homo sapiens	32-37
14658758-3	2003	Upon treating the MMCs either with cadmium (Cd) or spermine NONOate (SPER/NO), expression of HO-1 mRNA and protein was increased.	spermine nitric oxide complex	51-67	heme oxygenase 1	Mus musculus	93-97
14586658-3	2003	The NO donors S-nitroso-acetyl-D,L-penicillamine (SNAP) and N-[4-[1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl]-1,3-propanediamine (spermine-NONO) increased contractile responsiveness transiently in a concentration- and frequency-dependent manner.	spermine nitric oxide complex	60-138	non-POU domain containing, octamer-binding	Rattus norvegicus	149-153
12878207-3	2003	We found a dramatic increase in Nrf2 nuclear translocation 1-8h following the nitric oxide donor spermine NONOate.	spermine nitric oxide complex	97-113	NFE2 like bZIP transcription factor 2	Homo sapiens	32-36
12878207-6	2003	In addition to effects on Nrf2 subcellular localization, spermine NONOate increased Nrf2 protein levels by a mechanism which was inhibited by PD 98059.	spermine nitric oxide complex	57-73	NFE2 like bZIP transcription factor 2	Homo sapiens	84-88
12878207-7	2003	Pretreatment with N-acetylcysteine, PD 98059, and SB 203580 decreased HO-1 upregulation in spermine NONOate-treated cells.	spermine nitric oxide complex	91-107	heme oxygenase 1	Homo sapiens	70-74
12901850-2	2003	We have observed that nitrosoglutathione or another NO-generating compound spermine NONOate caused significant accumulation of IL-8 mRNA.	spermine nitric oxide complex	75-91	C-X-C motif chemokine ligand 8	Homo sapiens	127-131
12941159-6	2003	Using primary cultures of ovine pulmonary arterial endothelial cells we demonstrated that the NO donor SpermineNONOate, increased p21ras activity by 2.3-fold compared to untreated cells, and that the farnesyl-transferase inhibitor, alpha-hydroxyfarnesylphosphonic acid, reduced p21ras activity and significantly reduced inhibition of eNOS.	spermine nitric oxide complex	103-118	HRas proto-oncogene, GTPase	Homo sapiens	130-136
12941159-6	2003	Using primary cultures of ovine pulmonary arterial endothelial cells we demonstrated that the NO donor SpermineNONOate, increased p21ras activity by 2.3-fold compared to untreated cells, and that the farnesyl-transferase inhibitor, alpha-hydroxyfarnesylphosphonic acid, reduced p21ras activity and significantly reduced inhibition of eNOS.	spermine nitric oxide complex	103-118	HRas proto-oncogene, GTPase	Homo sapiens	278-284
12598534-6	2003	The effects of lipopolysaccharide were mimicked by the nitric oxide donors sodium nitroprusside and spermine NONOate, suggesting a role for nitric oxide in the lipopolysaccharide-mediated down-regulation of nonmuscle myosin heavy chain II-C induction.	spermine nitric oxide complex	100-116	myosin, heavy polypeptide 14	Mus musculus	207-240
12006578-7	2002	However, treatment with the NO donors S-nitroso-N-acetylpenicillamine and spermine NONOate [N-(-aminoethyl)N-(2-hydroxy-2-nitrohydrazino)-1,2-ethylenediamine) inhibited apoptosis and caspase 3 activity while significantly elevating NO levels above GCDC-stimulated levels.	spermine nitric oxide complex	74-90	caspase 3	Rattus norvegicus	183-192
12193733-3	2002	NO-releasing compounds (100 micro M S-nitrosoglutathione or 50 micro M spermine-NONOate) as well as inducible NO synthase induction provoked activation of PPARgamma.	spermine nitric oxide complex	71-87	peroxisome proliferator activated receptor gamma	Homo sapiens	155-164
12112002-2	2002	Here we show that NO donors including sodium nitroprusside (SNP) and spermine nonoate (SP-NO), and PGE(2) significantly stimulate HO-1 expression in RAW264.7 macrophages, associated with alternative induction on NO and PGE(2) in medium, respectively.	spermine nitric oxide complex	69-85	heme oxygenase 1	Homo sapiens	130-134
11773239-7	2002	Spermine-NO (100 microM; an NO donor) mimicked beta(2)-AR stimulation, and its effects were abolished by Rp-cAMPs.	spermine nitric oxide complex	0-11	adrenoceptor beta 2	Homo sapiens	47-57
12051519-4	2002	Additions of spermine NONOate, a nitric oxide donor, enhanced ET-1 levels in embryos from both control and n-stz diabetic rats, whereas N(G)-monomethyl-L-arginine, a nitric oxide inhibitor, diminished embryonic ET-1 content.	spermine nitric oxide complex	13-29	endothelin 1	Homo sapiens	62-66
11290515-5	2001	ecNOS antisense oligonucleotide decreased ecNOS protein, which prevented the increase in NO and albumin permeability at TNF-4 h. Spermine-NONOATE, the NO agonist, ablated the protective effect of ecNOS antisense oligonucleotide on albumin permeability in response to TNF-4 h. However, ecNOS antisense oligonucleotide had no effect on the TNF-induced increase in albumin permeability at 24 h despite prevention of the increase in NO.	spermine nitric oxide complex	129-145	nitric oxide synthase 3	Homo sapiens	0-5
11290515-5	2001	ecNOS antisense oligonucleotide decreased ecNOS protein, which prevented the increase in NO and albumin permeability at TNF-4 h. Spermine-NONOATE, the NO agonist, ablated the protective effect of ecNOS antisense oligonucleotide on albumin permeability in response to TNF-4 h. However, ecNOS antisense oligonucleotide had no effect on the TNF-induced increase in albumin permeability at 24 h despite prevention of the increase in NO.	spermine nitric oxide complex	129-145	nitric oxide synthase 3	Homo sapiens	42-47
11290515-5	2001	ecNOS antisense oligonucleotide decreased ecNOS protein, which prevented the increase in NO and albumin permeability at TNF-4 h. Spermine-NONOATE, the NO agonist, ablated the protective effect of ecNOS antisense oligonucleotide on albumin permeability in response to TNF-4 h. However, ecNOS antisense oligonucleotide had no effect on the TNF-induced increase in albumin permeability at 24 h despite prevention of the increase in NO.	spermine nitric oxide complex	129-145	tumor necrosis factor	Homo sapiens	120-123
11290515-5	2001	ecNOS antisense oligonucleotide decreased ecNOS protein, which prevented the increase in NO and albumin permeability at TNF-4 h. Spermine-NONOATE, the NO agonist, ablated the protective effect of ecNOS antisense oligonucleotide on albumin permeability in response to TNF-4 h. However, ecNOS antisense oligonucleotide had no effect on the TNF-induced increase in albumin permeability at 24 h despite prevention of the increase in NO.	spermine nitric oxide complex	129-145	nitric oxide synthase 3	Homo sapiens	42-47
11290515-5	2001	ecNOS antisense oligonucleotide decreased ecNOS protein, which prevented the increase in NO and albumin permeability at TNF-4 h. Spermine-NONOATE, the NO agonist, ablated the protective effect of ecNOS antisense oligonucleotide on albumin permeability in response to TNF-4 h. However, ecNOS antisense oligonucleotide had no effect on the TNF-induced increase in albumin permeability at 24 h despite prevention of the increase in NO.	spermine nitric oxide complex	129-145	tumor necrosis factor	Homo sapiens	267-270
11290515-5	2001	ecNOS antisense oligonucleotide decreased ecNOS protein, which prevented the increase in NO and albumin permeability at TNF-4 h. Spermine-NONOATE, the NO agonist, ablated the protective effect of ecNOS antisense oligonucleotide on albumin permeability in response to TNF-4 h. However, ecNOS antisense oligonucleotide had no effect on the TNF-induced increase in albumin permeability at 24 h despite prevention of the increase in NO.	spermine nitric oxide complex	129-145	nitric oxide synthase 3	Homo sapiens	42-47
11290515-5	2001	ecNOS antisense oligonucleotide decreased ecNOS protein, which prevented the increase in NO and albumin permeability at TNF-4 h. Spermine-NONOATE, the NO agonist, ablated the protective effect of ecNOS antisense oligonucleotide on albumin permeability in response to TNF-4 h. However, ecNOS antisense oligonucleotide had no effect on the TNF-induced increase in albumin permeability at 24 h despite prevention of the increase in NO.	spermine nitric oxide complex	129-145	tumor necrosis factor	Homo sapiens	267-270
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	134-150	heme oxygenase 1	Homo sapiens	54-70
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	134-150	heme oxygenase 1	Homo sapiens	72-76
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	134-150	heme oxygenase 1	Homo sapiens	166-170
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	152-156	heme oxygenase 1	Homo sapiens	54-70
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	152-156	heme oxygenase 1	Homo sapiens	72-76
11287117-1	2001	Unstimulated RAW 264.7 macrophages express negligible heme oxygenase-1 (HO-1) protein but incubation with the nitric oxide (NO) donor spermine nonoate (SPNO) induced HO-1 and weakly cyclo-oxygenase-2 (COX-2) protein.	spermine nitric oxide complex	152-156	heme oxygenase 1	Homo sapiens	166-170
11287117-3	2001	Cells incubated with SPNO showed a strong increase in HO-1 mRNA levels after 4 h with a significant potentiation in the presence of SC58125, which did not modify HO-1 mRNA stability.	spermine nitric oxide complex	21-25	heme oxygenase 1	Homo sapiens	54-58
11287117-3	2001	Cells incubated with SPNO showed a strong increase in HO-1 mRNA levels after 4 h with a significant potentiation in the presence of SC58125, which did not modify HO-1 mRNA stability.	spermine nitric oxide complex	21-25	heme oxygenase 1	Homo sapiens	162-166
11847418-4	2001	In presence of spermineNONOate there is an increase of erythrocyte deformability, plasma pH, decrease of Na(+) and Ca(2+) concentration, increase of metHb concentration and decrease of p50.	spermine nitric oxide complex	15-30	nuclear factor kappa B subunit 1	Homo sapiens	185-188
11833938-5	2001	In addition, we demonstrated a positive regulatory role of NO on the activity and protein expression of MMP-2 and MMP-9, because NO donors (NOC-18 and spermine-NONOate) or the NOS substrate (L-arginine) stimulate, whereas NOS inhibitors (N(G)-nitro-L-arginine methyl ester and N(G)-monomethyl-L-arginine) reduce the expression and gelatinolytic activity of MMP-2 and MMP-9 in isolated trophoblast cells.	spermine nitric oxide complex	151-167	matrix metallopeptidase 2	Homo sapiens	104-109
11833938-5	2001	In addition, we demonstrated a positive regulatory role of NO on the activity and protein expression of MMP-2 and MMP-9, because NO donors (NOC-18 and spermine-NONOate) or the NOS substrate (L-arginine) stimulate, whereas NOS inhibitors (N(G)-nitro-L-arginine methyl ester and N(G)-monomethyl-L-arginine) reduce the expression and gelatinolytic activity of MMP-2 and MMP-9 in isolated trophoblast cells.	spermine nitric oxide complex	151-167	matrix metallopeptidase 9	Homo sapiens	114-119
10021319-6	1999	The longer-lived NO donor spermine-NO causes a comparable rapid activation of the p38-MAPK pathway; however, the increased activation state of p38-MAPK was maintained for several hours before control values were reattained after 24 h of stimulation.	spermine nitric oxide complex	26-37	mitogen-activated protein kinase 14	Homo sapiens	82-85
11046123-6	2000	Estimated IC(50) values for vascular cell adhesion molecule-1 were >400 microM for SP/W 4744 (control for SP/W 3672 lacking the cysteine moiety), 200 microM for GSNO and spermine NONOate, 80 microM for SP/W 3672, and 50 microM for SP/W 5186.	spermine nitric oxide complex	173-189	vascular cell adhesion molecule 1	Homo sapiens	28-61
10896023-2	2000	Attachment of these cells to fibronectin was significantly inhibited by NO donors, spermine NONOate and S-nitroso-N-acetyl-penicillamine or L-arginine, but not 8-bromoguanosine-3",5"-cyclic-monophosphate.	spermine nitric oxide complex	83-99	fibronectin 1	Homo sapiens	29-40
10780998-5	2000	Incubation of cells with NO donors, spermine nonoate (SPNO) and S-nitroso-N-acetylpenicillamine (SNAP), induced a dose- and time-dependent expression of HO-1 protein.	spermine nitric oxide complex	36-52	heme oxygenase 1	Homo sapiens	153-157
10780998-5	2000	Incubation of cells with NO donors, spermine nonoate (SPNO) and S-nitroso-N-acetylpenicillamine (SNAP), induced a dose- and time-dependent expression of HO-1 protein.	spermine nitric oxide complex	54-58	heme oxygenase 1	Homo sapiens	153-157
10780998-8	2000	COX-2 protein was weakly induced by SPNO in basal conditions and in the presence of LPS a synergy for HO-1 and COX-2 protein expression was observed.	spermine nitric oxide complex	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
10780998-8	2000	COX-2 protein was weakly induced by SPNO in basal conditions and in the presence of LPS a synergy for HO-1 and COX-2 protein expression was observed.	spermine nitric oxide complex	36-40	heme oxygenase 1	Homo sapiens	102-106
10780998-8	2000	COX-2 protein was weakly induced by SPNO in basal conditions and in the presence of LPS a synergy for HO-1 and COX-2 protein expression was observed.	spermine nitric oxide complex	36-40	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
10780998-10	2000	Our results indicate that reactive oxygen species participate in the inductive effect of NO donors or LPS on HO-1 expression, whereas endogenous NO production may play a role in the mechanism of the synergy exhibited by SPNO and LPS on HO-1 and COX-2 expression.	spermine nitric oxide complex	220-224	heme oxygenase 1	Homo sapiens	236-240
10780998-10	2000	Our results indicate that reactive oxygen species participate in the inductive effect of NO donors or LPS on HO-1 expression, whereas endogenous NO production may play a role in the mechanism of the synergy exhibited by SPNO and LPS on HO-1 and COX-2 expression.	spermine nitric oxide complex	220-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	245-250
10849669-8	2000	Hypoxia-induced c-fos mRNA expression, and promoter activities were significantly potentiated in presence of spermine nitric oxide (SNO), a NO donor.	spermine nitric oxide complex	109-130	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-21
10849669-8	2000	Hypoxia-induced c-fos mRNA expression, and promoter activities were significantly potentiated in presence of spermine nitric oxide (SNO), a NO donor.	spermine nitric oxide complex	132-135	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	16-21
10849669-9	2000	By contrast, SNO significantly inhibited TH mRNA expression and TH promoter activity during hypoxia.	spermine nitric oxide complex	13-16	tyrosine hydroxylase	Rattus norvegicus	41-43
10849669-9	2000	By contrast, SNO significantly inhibited TH mRNA expression and TH promoter activity during hypoxia.	spermine nitric oxide complex	13-16	tyrosine hydroxylase	Rattus norvegicus	64-66
10849669-11	2000	SNO abolished the binding of AP-1 and HIF-1 to the TH promoter during hypoxia, suggesting that inhibition of hypoxia-induced TH transcription by NO are due to reduced binding of AP-1 and HIF-1 transcription factors.	spermine nitric oxide complex	0-3	tyrosine hydroxylase	Rattus norvegicus	51-53
10849669-11	2000	SNO abolished the binding of AP-1 and HIF-1 to the TH promoter during hypoxia, suggesting that inhibition of hypoxia-induced TH transcription by NO are due to reduced binding of AP-1 and HIF-1 transcription factors.	spermine nitric oxide complex	0-3	tyrosine hydroxylase	Rattus norvegicus	125-127
10369455-4	1999	Incubation of mesangial cells with the NO-donor, spermine-NONOate, for 24 h induced sPLA2-IIA mRNA expression and activity, whereas S-nitroso glutathione alone had only a small stimulatory effect.	spermine nitric oxide complex	49-65	phospholipase A2 group IIA	Rattus norvegicus	84-89
10350003-5	1999	Similarly, cyclic GMP elevations by the spontaneous nitric oxide donors sodium nitroprusside and spermine NONOate were not affected after pretreatment with glyceryl trinitrate.	spermine nitric oxide complex	97-113	5'-nucleotidase, cytosolic II	Homo sapiens	18-21
10195928-8	1999	NO donor spermine-NONOate (SPR/NO) dose-dependently reduced the MCP-1 and PDGF-A expression induced by impulse flow.	spermine nitric oxide complex	9-25	sepiapterin reductase	Homo sapiens	27-30
10195928-8	1999	NO donor spermine-NONOate (SPR/NO) dose-dependently reduced the MCP-1 and PDGF-A expression induced by impulse flow.	spermine nitric oxide complex	9-25	C-C motif chemokine ligand 2	Homo sapiens	64-69
10195928-8	1999	NO donor spermine-NONOate (SPR/NO) dose-dependently reduced the MCP-1 and PDGF-A expression induced by impulse flow.	spermine nitric oxide complex	9-25	platelet derived growth factor subunit A	Homo sapiens	74-80
10868913-10	2000	The NO-releasing agent spermine-NONOate but not peroxynitrite enhanced induction of OPN mRNA.	spermine nitric oxide complex	23-39	secreted phosphoprotein 1	Mus musculus	84-87
10550420-11	1999	In control rats Spermine NONOate effectively prevented P-selectin up regulation, whereas in diabetic rats NO appreciably attenuated the rapid up regulation of ICAM-1 by preventing its transcription.	spermine nitric oxide complex	16-32	selectin P	Rattus norvegicus	55-65
10021319-6	1999	The longer-lived NO donor spermine-NO causes a comparable rapid activation of the p38-MAPK pathway; however, the increased activation state of p38-MAPK was maintained for several hours before control values were reattained after 24 h of stimulation.	spermine nitric oxide complex	26-37	mitogen-activated protein kinase 14	Homo sapiens	82-90
10021319-8	1999	Both MAHMA-NO and spermine-NO cause a rapid activation of p44-MAPK after 10 min of stimulation.	spermine nitric oxide complex	18-29	general transcription factor IIH subunit 2	Homo sapiens	58-61
9642108-1	1998	Spermine NONOate (SpNO, a nitric oxide donor) induced apoptosis and caspase-3 activity in the macrophage cell line RAW 267.4.	spermine nitric oxide complex	0-16	caspase 3	Homo sapiens	68-77
9765252-6	1998	However, peroxynitrite formed from .NO and O-2, which were generated at equal rates ( approximately 5 microM x min-1) from 1 mM spermine NONOate, 28 milliunits/ml xanthine oxidase, and 1 mM hypoxanthine was much less efficient (0.67 +/- 0.01 microM; approximately 0.07% of total product flow).	spermine nitric oxide complex	128-144	immunoglobulin kappa variable 1D-39	Homo sapiens	43-46
10065760-7	1999	P-selectin surface expression induced by 1 mM SNO was also significantly inhibited by 0.5 microM KT5823.	spermine nitric oxide complex	46-49	selectin P	Homo sapiens	0-10
10065760-8	1999	Conversely, a cytoplasm calcium chelator, TMB-8 (0.1 mM), significantly exacerbated both the neutrophil adhesion and P-selectin expression induced by SNO.	spermine nitric oxide complex	150-153	selectin P	Homo sapiens	117-127
9826526-6	1998	Treatment of RAW 264.7 macrophages with the NO* donor spermine NONOate also induced a nitration of the p85 subunit, demonstrating that this covalent modification also occurs in intact cells.	spermine nitric oxide complex	54-70	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	103-106
9642108-1	1998	Spermine NONOate (SpNO, a nitric oxide donor) induced apoptosis and caspase-3 activity in the macrophage cell line RAW 267.4.	spermine nitric oxide complex	18-22	caspase 3	Homo sapiens	68-77
9642108-2	1998	RES cells that have been derived from RAW 267.4 cells by repeated exposure to lipopolysaccharide and interferon-gamma (LPS/INF-gamma), followed by outgrowth of viable cells, are resistant to apoptosis and caspase-3 activation upon exposure to SpNO.	spermine nitric oxide complex	243-247	interferon regulatory factor 6	Homo sapiens	119-132
9065784-4	1997	In this study we observed that the NO donor, spermine NONOate did not inhibit the activation and translocation of NF-kappaB, a key transcription factor in the induction of NOS-2, but inhibited formation of the NF-kappaB-DNA complex.	spermine nitric oxide complex	45-61	nuclear factor kappa B subunit 1	Homo sapiens	210-219
9374724-4	1997	We demonstrate that the NO donor spermine NONOate (SNN) increases steady-state levels of HO-1 mRNA in aortic vascular smooth muscle cells (aSMC) in both a time- and dose-dependent manner.	spermine nitric oxide complex	33-49	heme oxygenase 1	Homo sapiens	89-93
9374724-4	1997	We demonstrate that the NO donor spermine NONOate (SNN) increases steady-state levels of HO-1 mRNA in aortic vascular smooth muscle cells (aSMC) in both a time- and dose-dependent manner.	spermine nitric oxide complex	51-54	heme oxygenase 1	Homo sapiens	89-93
9374724-8	1997	The antioxidant N-acetyl-L-cysteine markedly inhibited SNN-induced HO-1 mRNA expression, whereas peroxynitrite did not induce HO-1 expression in aSMC.	spermine nitric oxide complex	55-58	heme oxygenase 1	Homo sapiens	67-71
9328209-2	1997	In this study, we observed that liberators of NO such as S-nitroso-N-acetyl-penicillamine (SNAP), sodium nitroprusside (Snp) and spermine nonoate (SNO) could significantly inhibit angiotensin II (AII) and ACTH-induced aldosterone synthesis in isolated rat and cultured human adrenal glomerulosa cells.	spermine nitric oxide complex	129-145	angiotensinogen	Rattus norvegicus	180-194
9328209-2	1997	In this study, we observed that liberators of NO such as S-nitroso-N-acetyl-penicillamine (SNAP), sodium nitroprusside (Snp) and spermine nonoate (SNO) could significantly inhibit angiotensin II (AII) and ACTH-induced aldosterone synthesis in isolated rat and cultured human adrenal glomerulosa cells.	spermine nitric oxide complex	129-145	angiotensinogen	Rattus norvegicus	196-199
9328209-2	1997	In this study, we observed that liberators of NO such as S-nitroso-N-acetyl-penicillamine (SNAP), sodium nitroprusside (Snp) and spermine nonoate (SNO) could significantly inhibit angiotensin II (AII) and ACTH-induced aldosterone synthesis in isolated rat and cultured human adrenal glomerulosa cells.	spermine nitric oxide complex	147-150	angiotensinogen	Rattus norvegicus	180-194
9328209-2	1997	In this study, we observed that liberators of NO such as S-nitroso-N-acetyl-penicillamine (SNAP), sodium nitroprusside (Snp) and spermine nonoate (SNO) could significantly inhibit angiotensin II (AII) and ACTH-induced aldosterone synthesis in isolated rat and cultured human adrenal glomerulosa cells.	spermine nitric oxide complex	147-150	angiotensinogen	Rattus norvegicus	196-199
35354949-6	2022	TRPV1 expression in A549 and NCI-H292 cells was increased after pretreatment with cigarette smoke extract or spermine NONOate.	spermine nitric oxide complex	109-125	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
8702745-5	1996	Bcl-2 transfectants showed substantial protection from cell death induced following the exposure to NO donors such as S-nitrosoglutathione (GSNO) and spermine-NO.	spermine nitric oxide complex	150-161	B cell leukemia/lymphoma 2	Mus musculus	0-5
8760103-4	1996	Our results show that 1) L-NAME significantly increased baseline vascular resistance and this response was reduced by L-arginine, 2) ET-1-induced vasoconstriction was enhanced by L-NAME, and 3) administration of spermine NONOate during reperfusion largely attenuated the vasoconstrictor response to ET-1 after ischemia-reperfusion.	spermine nitric oxide complex	212-228	endothelin 1	Canis lupus familiaris	133-137
8760103-4	1996	Our results show that 1) L-NAME significantly increased baseline vascular resistance and this response was reduced by L-arginine, 2) ET-1-induced vasoconstriction was enhanced by L-NAME, and 3) administration of spermine NONOate during reperfusion largely attenuated the vasoconstrictor response to ET-1 after ischemia-reperfusion.	spermine nitric oxide complex	212-228	endothelin 1	Canis lupus familiaris	299-303
8548905-4	1996	The mast cell-induced histamine-dependent rolling and PAF-dependent adhesion were completely inhibited by the addition of the NO donor spermine NO.	spermine nitric oxide complex	135-146	PCNA clamp associated factor	Homo sapiens	54-57
8548905-5	1996	However, spermine NO did not directly inhibit histamine-induced leukocyte rolling and only partly affected PAF-induced leukocyte adhesion.	spermine nitric oxide complex	9-20	PCNA clamp associated factor	Homo sapiens	107-110
28302706-6	2017	Mast cell degranulation by MCP-1 was prevented by the NO donor spermine-NONOate.	spermine nitric oxide complex	63-79	C-C motif chemokine ligand 2	Homo sapiens	27-32