PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23788428-4 2013 Here, we present the novel finding that LMP induced by the addition of TNFalpha plus cycloheximide (CHX), the release of lysosomal cathepsins and ROS formation do not occur upstream but downstream of MOMP and require the caspase-3-mediated cleavage of the p75 NDUFS1 subunit of respiratory complex I. Cycloheximide 85-98 caspase 3 Homo sapiens 221-230 30902881-6 2019 Importantly, the loss of cIAP1 enhanced TNF-alpha/cycloheximide-induced apoptosis in higher activation statuses of Caspase-8, Caspase-3 without the induction of Complex II. Cycloheximide 50-63 caspase 3 Homo sapiens 126-135 26508734-4 2016 We also identified mitochondrial isoforms of Pim-1 kinase that were targeted for degradation by AZ58 in combination with TNF-alpha or AZ58 in combination with Fas ligand (FasL) plus cycloheximide (CHX) through caspase-3 to block transformation. Cycloheximide 182-195 caspase 3 Homo sapiens 210-219 19559790-4 2009 In the presence of cycloheximide (CHX), an increase in intracellular caspase-3/7 activity in response to LPS was not detected in HUVEC up to 24 h following stimulation even in the presence of LPS-binding protein (LBP), soluble CD14 and soluble MD-2, whereas the decrease in cell viability and increase in release of the cellular enzyme lactate dehydrogenase (LDH) were observed in a soluble CD14/LBP-dependent manner. Cycloheximide 34-37 caspase 3 Homo sapiens 69-78 22253441-5 2012 The neuronal death produced by prolonged CaMKII inhibition is associated with an increase in TUNEL staining and caspase-3 cleavage and is blocked with the translation inhibitor cycloheximide. Cycloheximide 177-190 caspase 3 Homo sapiens 112-121 20599703-0 2010 NKX3.1 potentiates TNF-alpha/CHX-induced apoptosis of prostate cancer cells through increasing caspase-3 expression and its activity. Cycloheximide 29-32 caspase 3 Homo sapiens 95-104 19559790-4 2009 In the presence of cycloheximide (CHX), an increase in intracellular caspase-3/7 activity in response to LPS was not detected in HUVEC up to 24 h following stimulation even in the presence of LPS-binding protein (LBP), soluble CD14 and soluble MD-2, whereas the decrease in cell viability and increase in release of the cellular enzyme lactate dehydrogenase (LDH) were observed in a soluble CD14/LBP-dependent manner. Cycloheximide 19-32 caspase 3 Homo sapiens 69-78 11226410-2 2001 We have found that treatment of A431 cells with tumor necrosis factor-alpha in the presence of cycloheximide resulted in the cleavage of epidermal growth factor receptor (EGFR) as well as the activation of caspase-3. Cycloheximide 95-108 caspase 3 Homo sapiens 206-215 18231987-5 2008 A short treatment with DENSPM did not reduce cell viability when given alone, but enhanced caspase-3 and -9 activation in chondrocytes exposed to tumor necrosis factor-alpha (TNF) and cycloheximide (CHX). Cycloheximide 184-197 caspase 3 Homo sapiens 91-107 18231987-5 2008 A short treatment with DENSPM did not reduce cell viability when given alone, but enhanced caspase-3 and -9 activation in chondrocytes exposed to tumor necrosis factor-alpha (TNF) and cycloheximide (CHX). Cycloheximide 199-202 caspase 3 Homo sapiens 91-107 16478887-6 2006 Plasminogen treatment also markedly reduced internucleosomal DNA fragmentation and reduced levels of active caspase 3, caspase 8, and caspase 9 induced by TNFalpha or by cycloheximide. Cycloheximide 170-183 caspase 3 Homo sapiens 108-117 16626937-6 2006 However when apoptosis was stimulated with cycloheximide, the schizophrenia group showed an attenuated caspase-3 response. Cycloheximide 43-56 caspase 3 Homo sapiens 103-112 16487927-5 2006 Overexpression of Monad in HEK293 cells potentiated apoptosis and caspase-3 activation induced by tumor necrosis factor-alpha and cycloheximide. Cycloheximide 130-143 caspase 3 Homo sapiens 66-75 16546965-8 2006 Pretreatment with cycloheximide showed that active caspase-3 fragments have a high turnover rate in OVCAR3 R350 cells. Cycloheximide 18-31 caspase 3 Homo sapiens 51-60 15078986-9 2004 De novo protein synthesis was required for initiation of apoptosis in that the protein synthesis inhibitor, cycloheximide, inhibited SBHA-induced conformational changes in Bax as well as changes in mitochondrial membrane permeability and activation of caspase-3. Cycloheximide 108-121 caspase 3 Homo sapiens 252-261 11850832-7 2002 Although cycloheximide did not further accelerate the processing of caspases 3 and 8, it significantly enhanced cleavage of the caspase 3 substrate gelsolin, indicating that in PrEC a protein(s) with a short half-life may inhibit the activity of the executioner caspases toward specific substrates. Cycloheximide 9-22 caspase 3 Homo sapiens 128-137 18474237-5 2008 Cycloheximide or actinomycin D blocked caspase-11 induction, reduced caspase-11 and -3 activation, and attenuated TPEN-induced neuronal apoptosis. Cycloheximide 0-13 caspase 3 Homo sapiens 69-86 15528219-7 2005 Pre-treatment of cells with caspase-8 or -9 inhibitor, pan caspase inhibitor or cycloheximide totally blocked alpha-santalol-caused caspase-3 activity and cleavage, but only partially reversed apoptotic cell death. Cycloheximide 80-93 caspase 3 Homo sapiens 132-141 12209935-6 2002 Comparative studies with neutrophils adherent under static conditions demonstrated time-dependent activation of caspases in TNF-alpha/cycloheximide-induced apoptosis, for which caspase-3 also was implicated. Cycloheximide 134-147 caspase 3 Homo sapiens 177-186 11849390-11 2002 Blocking caspase-3 activity prevented apoptosis in TNF-alpha with cycloheximide-treated cells (83% to 2%) and prevented compromised respiratory burst in response to ANCA. Cycloheximide 66-79 caspase 3 Homo sapiens 9-18 11698395-7 2002 The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis. Cycloheximide 16-29 caspase 3 Homo sapiens 62-71 11698395-7 2002 The addition of cycloheximide greatly inhibited activation of caspase-3 by apicidin by interfering with cleavage of procaspase-3 and DNA fragmentation, suggesting that apicidin-induced apoptosis was dependent on de novo protein synthesis. Cycloheximide 16-29 caspase 3 Homo sapiens 116-128 11313933-3 2001 This fragmentation was inhibited by the caspase inhibitor, z-VAD-fmk and by cycloheximide, which also prevented proteolytic activation of caspase-3 and poly(ADP-ribose)polymerase cleavage. Cycloheximide 76-89 caspase 3 Homo sapiens 138-147 10955723-6 2000 The staurosporine-induced DNA ladder formation was accompanied by an increase in caspase-3 activity in both lines which, however, was considerably lower in Jurkat JM cells after gemcitabine or cycloheximide exposure. Cycloheximide 193-206 caspase 3 Homo sapiens 81-90 11187905-7 2000 Furthermore, protein synthesis inhibition by cycloheximide restored sensitivity to CD95-mediated apoptosis and allowed activation of both caspase-8 and caspase-3 in BR97 cells. Cycloheximide 45-58 caspase 3 Homo sapiens 152-161 11068016-5 2000 Caspase-3 activation by TNF-alpha was significantly enhanced by pretreatment with both cycloheximide and pyrrolidine dithiocarbamate. Cycloheximide 87-100 caspase 3 Homo sapiens 0-9 10673748-5 2000 The proteolytic processing of procaspases-8 and -3 to produce active fragments, caspases-8 (p18) and -3 (p17), respectively, was observed after treatment with 2CdA, and suppressed by cycloheximide. Cycloheximide 183-196 caspase 3 Homo sapiens 30-50 10355595-5 1999 DbcAMP also inhibited the TNF-alpha/cycloheximide-induced activation of caspase-3, but it had no effect on the activation of caspase-8 in human neutrophils. Cycloheximide 36-49 caspase 3 Homo sapiens 72-81 10381626-5 1999 Exposure of TPA-differentiated U937 cells to 0.8 microg/ml cycloheximide for 24 h, that triggers apoptosis in 50% cells, activates procaspase-2L, -3 and -8, induces the mitochondrial release of cytochrome c and decreases Bcl-xL expression without modifying Bcl-2, Mcl-1 and Bax protein levels. Cycloheximide 59-72 caspase 3 Homo sapiens 131-155 10066786-4 1999 In T-cells undergoing CHX-induced apoptosis (Jurkat), but not in T-cells resistant to the effects of CHX (CEM C7), caspase-8 and caspase-3 were activated. Cycloheximide 22-25 caspase 3 Homo sapiens 129-138