PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20336802-1	2010	A computational investigation has been carried out on CYP2A6 and its naphthalene inhibitors to explore the crucial molecular features contributing to binding specificity.	naphthalene	69-80	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	54-60	
967161-7	1976	Induction with either naphthalene or phenobarbital appears to increase cytochrome P-450I preferentially.	naphthalene	22-33	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	71-88	
19110342-1	2009	A series of naphthalene and non-naphthalene derivatives (n=42) having cytochrome P450 2A6 and 2A5 inhibitory activities, reported by Rahnasto et al., were subjected to QSAR and QAAR studies.	naphthalene	12-23	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	70-97	
15658857-2	2005	The inhibitory potencies of 26 naphthalene and 16 non-naphthalene derivatives were determined for human CYP2A6 and mouse CYP2A5 enzymes.	naphthalene	31-42	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	104-110	
15658857-2	2005	The inhibitory potencies of 26 naphthalene and 16 non-naphthalene derivatives were determined for human CYP2A6 and mouse CYP2A5 enzymes.	naphthalene	54-65	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	104-110	
12849728-0	2003	Predictive value of comparative molecular field analysis modelling of naphthalene inhibition of human CYP2A6 and mouse CYP2A5 enzymes.	naphthalene	70-81	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	102-108	
12849728-1	2003	The objects of this study were first to compare how well the recently constructed structure-inhibition activity relationship models of mouse CYP2A5 and human CYP2A6 predict the interaction of naphthalene in liver microsomes and secondly to study if these CYP enzymes actually oxidize naphthalene.	naphthalene	192-203	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	158-164	
12849728-2	2003	The CoMFA model of CYP2A5 predicted the IC(50) value of naphthalene to be 42 microM (18-115 microM 95% CL) whereas in the in vitro experiment the result was 74 microM (65-83 microM) with the corresponding values for CYP2A6 being 41 microM (18-112 microM) and 25 microM (21-30 microM), respectively.	naphthalene	56-67	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	216-222	
12849728-3	2003	Naphthalene appeared to be a competitive inhibitor both for mouse and human liver microsomal coumarin 7-hydroxylase, which is the specific probe activity for CYP2A5 and CYP2A6.	naphthalene	0-11	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	93-115	
12849728-3	2003	Naphthalene appeared to be a competitive inhibitor both for mouse and human liver microsomal coumarin 7-hydroxylase, which is the specific probe activity for CYP2A5 and CYP2A6.	naphthalene	0-11	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	169-175	
12849728-7	2003	These results indicate that in silico CoMFA models predict relatively well the interaction of naphthalene with CYP2A5 and CYP2A6 and that these CYPs actually oxidize naphthalene in vitro.	naphthalene	94-105	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	122-128