PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
27767186-0	2016	Recombinant Reg3beta protein protects against streptozotocin-induced beta-cell damage and diabetes.	Streptozocin	46-60	regenerating islet-derived 3 beta	Mus musculus	12-20	
27259509-2	2016	In our previous study, we reported that Reg3beta overexpression did not increase islet growth but prevented streptozotocin-induced islet damage by inducing specific genes.	Streptozocin	108-122	regenerating islet-derived 3 beta	Mus musculus	40-48	
27767186-2	2016	Our recent study discovered that pancreatic beta-cell-specific overexpression of Reg3beta protects against streptozotocin (Stz) -induced diabetes in mice.	Streptozocin	107-121	regenerating islet-derived 3 beta	Mus musculus	81-89	
27767186-2	2016	Our recent study discovered that pancreatic beta-cell-specific overexpression of Reg3beta protects against streptozotocin (Stz) -induced diabetes in mice.	Streptozocin	123-126	regenerating islet-derived 3 beta	Mus musculus	81-89	
27767186-3	2016	To investigate its potential roles in the treatment of diabetes, we produced a recombinant Reg3beta protein and provided evidence that it is active in promoting islet beta-cell survival against Stz- triggered cell death.	Streptozocin	194-197	regenerating islet-derived 3 beta	Mus musculus	91-99	
27767186-4	2016	Though ineffective in alleviating preexisting diabetes, pretreatment of recombinant Reg3beta was capable of minimizing the Stz-induced hyperglycemia and weight loss, by preserving serum and pancreatic insulin levels, and islet beta-cell mass.	Streptozocin	123-126	regenerating islet-derived 3 beta	Mus musculus	84-92	
21351584-0	2010	[Recombination of RegIII-proinsulin-pBudCE4.1 plasmid and its therapeutic effect on STZ-induced type 1 diabetes mellitus].	Streptozocin	84-87	regenerating islet-derived 3 beta	Mus musculus	18-24	
27376728-6	2016	STZ-induced diabetic mice developed intestinal defense impairment as demonstrated by decreased mucosal bacteria-killing activity; reduction of non-defensin family proteins, such as Reg3beta, Reg3gamma, CRP-ductin and RELMbeta, but not the defensin family proteins; and increased bacterial translocation.	Streptozocin	0-3	regenerating islet-derived 3 beta	Mus musculus	181-189	
21245462-0	2011	Pancreatic islet-specific overexpression of Reg3beta protein induced the expression of pro-islet genes and protected the mice against streptozotocin-induced diabetes mellitus.	Streptozocin	134-148	regenerating islet-derived 3 beta	Mus musculus	44-52	
21245462-6	2011	Upon streptozotocin treatment, in contrast to wild-type littermates that became hyperglycemic in 3 days and lost 15% of their weight, RIP-I/Reg3beta mice were significantly protected from hyperglycemia and weight loss.	Streptozocin	5-19	regenerating islet-derived 3 beta	Mus musculus	140-148	
21245462-9	2011	Our results suggest that Reg3beta is unlikely an islet growth factor but a putative protector that prevents streptozotocin-induced damage by inducing the expression of specific genes.	Streptozocin	108-122	regenerating islet-derived 3 beta	Mus musculus	25-33	
21351584-1	2010	The aim of this study is to investigate the therapeutic effect of RegIII-proinsulin-pBudCE4.1 plasmid on streptozotocin (STZ)-induced type 1 diabetes mellitus and its underlying mechanisms.	Streptozocin	105-119	regenerating islet-derived 3 beta	Mus musculus	66-72	
21351584-1	2010	The aim of this study is to investigate the therapeutic effect of RegIII-proinsulin-pBudCE4.1 plasmid on streptozotocin (STZ)-induced type 1 diabetes mellitus and its underlying mechanisms.	Streptozocin	121-124	regenerating islet-derived 3 beta	Mus musculus	66-72