PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
34030609-5	2021	Overexpressed interleukin (IL)-6 induced the MEK5/ERK5, JAK2/STAT3, and MAPK signalling cascades in streptozotocin-induced diabetic rats.	Streptozocin	100-114	Janus kinase 2	Rattus norvegicus	56-60	
24802166-8	2014	Additionally, adenovirus-mediated upregulation of renal SOCS2 markedly inhibited STZ-induced phosphorylation increases of Janus kinase (JAK) 2, signal transducer and activator of transcription (STAT) 3, STAT5 and extracellular receptor-activated kinase (ERK) 1/2.	Streptozocin	81-84	Janus kinase 2	Rattus norvegicus	122-142	
15601754-8	2005	Treatment of streptozotocin-induced diabetic rats with ketanserin (5 mg.kg-1.day-1) reduced activation of JAK2 and STAT1 but not STAT3 in endothelium-denuded thoracic aorta in vivo.	Streptozocin	13-27	Janus kinase 2	Rattus norvegicus	106-110	
17526654-9	2007	These results demonstrate that JAK2 activation in vivo participates in the development of vascular complications associated with STZ-induced diabetes.	Streptozocin	129-132	Janus kinase 2	Rattus norvegicus	31-35	
16449352-4	2006	Consistent with these in vitro results, both albumin protein excretion and phosphorylation of JAK2, STAT1, and STAT3 were attenuated in renal glomeruli by administration of simvastatin in a streptozotocin-induced rat model of HG diabetes.	Streptozocin	190-204	Janus kinase 2	Rattus norvegicus	94-98	
16290054-7	2005	In vivo administration of apocynin (1.5 mM) resulted in a significant decrease ( 50%), while the ETA receptor antagonist ABT-627 completely inhibited phosphorylation of JAK2 in aortae from STZ-induced diabetic rats.	Streptozocin	189-192	Janus kinase 2	Rattus norvegicus	169-173	
14678947-8	2004	STZ stimulated glomerular phosphorylation of JAK2, STAT1, STAT3, and STAT5.	Streptozocin	0-3	Janus kinase 2	Rattus norvegicus	45-49	
35219163-16	2022	Besides, STZ-induced inflammatory response, oxidative stress, and phosphorylation levels of PI3K, AKT, JAK2, and STAT3 were reduced by CAD in the rats.	Streptozocin	9-12	Janus kinase 2	Rattus norvegicus	103-107	
12086960-4	2002	Our results demonstrate that JAK2, insulin receptor substrate (IRS)-1, Shc, ERKs, and Akt are widely distributed in the kidney, and after GH treatment, there is a significant increase in phosphorylation of these proteins in STZ-induced diabetic rats compared with controls.	Streptozocin	224-227	Janus kinase 2	Rattus norvegicus	29-33	
34178835-11	2021	Results: Oral administration of M. charantia nanoparticles (50 mg/kg) to STZ-induced diabetic untreated rats significantly ((p < 0.05) down-regulated the mRNA expression of Akt, PI3k, TGF-beta, JAK2, STAT3 and upregulated the mRNA expression of PTEN, SOCS3 and SOCS4, thus establishing the role of M. charantia nanoparticles in alleviating DN in diabetic rats.	Streptozocin	73-76	Janus kinase 2	Rattus norvegicus	194-198