PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26002932-0 2015 Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model. Streptozocin 84-98 signal transducer and activator of transcription 3 Mus musculus 17-22 30444022-8 2019 As STAT3 inhibition reversed the effects of IL-6-treated microglial cells on the RPE monolayer in vitro, it reduced the recruitment of microglial cells and the production of TNF-alpha in RPE tissues in streptozotocin-treated mice. Streptozocin 202-216 signal transducer and activator of transcription 3 Mus musculus 3-8 31097787-4 2020 By knocking out STAT3 specifically in mouse beta-cells, we found that the loss of STAT3 sensitized mice to three low doses of STZ stimulation resulting in hyperglycemia. Streptozocin 126-129 signal transducer and activator of transcription 3 Mus musculus 16-21 24682898-6 2014 CNTF treatment prevented reduced STAT3 phosphorylation (Tyr 705) in DRG of STZ-diabetic mice and also enhanced STAT3 phosphorylation in rat DRG cultures. Streptozocin 75-78 signal transducer and activator of transcription 3 Mus musculus 33-38 24152426-7 2013 STAT3 phosphorylation on Tyr705 or Ser727 was depressed in DRG from STZ-diabetic mice and treatment of cultures derived from STZ-diabetic rats with IL-1beta for 30 min raised phosphorylation of STAT3 on Tyr705 and Ser727 by 1.5 to 2-fold (p<0.05). Streptozocin 68-71 signal transducer and activator of transcription 3 Mus musculus 0-5 24152426-7 2013 STAT3 phosphorylation on Tyr705 or Ser727 was depressed in DRG from STZ-diabetic mice and treatment of cultures derived from STZ-diabetic rats with IL-1beta for 30 min raised phosphorylation of STAT3 on Tyr705 and Ser727 by 1.5 to 2-fold (p<0.05). Streptozocin 125-128 signal transducer and activator of transcription 3 Mus musculus 0-5 34839589-12 2022 Mice with STZ-induced diabetes showed elevated expressions of circZNF532, STAT3, but decreased level of miR-20b-5p compared with the controls. Streptozocin 10-13 signal transducer and activator of transcription 3 Mus musculus 74-79 34518585-9 2021 Moreover, leptin-induced p-JAK2 and p-STAT3 signaling in the hypothalamus of Stz + TUDCA mice was improved, accompanied by reduced acute food intake after leptin stimulation. Streptozocin 77-80 signal transducer and activator of transcription 3 Mus musculus 38-43 35599279-10 2022 In STZ-induced mice, retinal vascular leakage, p-JAK1, p-JAK2, p-JAK3, p-STAT3, and VEGF were significantly increased after diabetes induction. Streptozocin 3-6 signal transducer and activator of transcription 3 Mus musculus 73-78 33754353-6 2021 Using a streptozotocin-induced type 1 DM model, we showed enhanced hippocampal neuronal apoptosis that was associated with increased STAT3 activation. Streptozocin 8-22 signal transducer and activator of transcription 3 Mus musculus 133-138 31097787-4 2020 By knocking out STAT3 specifically in mouse beta-cells, we found that the loss of STAT3 sensitized mice to three low doses of STZ stimulation resulting in hyperglycemia. Streptozocin 126-129 signal transducer and activator of transcription 3 Mus musculus 82-87 31277074-0 2019 Inhibition of EGFR-STAT3 attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes. Streptozocin 54-68 signal transducer and activator of transcription 3 Mus musculus 19-24 31699972-3 2019 Treatment with selective STAT3 inhibitor, S3I-201 for 16 weeks significantly attenuated kidney injuries in streptozotocin (STZ) induced diabetic mice, associated with downregulated expression of TGF-beta1, ACE/AT1, and VEGF in diabetic mouse kidneys. Streptozocin 123-126 signal transducer and activator of transcription 3 Mus musculus 25-30 31699972-0 2019 Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice. Streptozocin 92-95 signal transducer and activator of transcription 3 Mus musculus 14-19 31699972-3 2019 Treatment with selective STAT3 inhibitor, S3I-201 for 16 weeks significantly attenuated kidney injuries in streptozotocin (STZ) induced diabetic mice, associated with downregulated expression of TGF-beta1, ACE/AT1, and VEGF in diabetic mouse kidneys. Streptozocin 107-121 signal transducer and activator of transcription 3 Mus musculus 25-30