PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30317639-0	2019	Proinsulin C-peptide as an alternative or combined treatment with insulin for management of testicular dysfunction and fertility impairments in streptozotocin-induced type 1 diabetic male rats.	Streptozocin	144-158	insulin 2	Rattus norvegicus	11-20	
31669668-10	2020	The methanol extract of the plant prevented the diabetogenic effect of STZ and significantly lowered the fasting blood glucose level, glycated haemoglobin and increased insulin and C-peptide level in treated rats.	Streptozocin	71-74	insulin 2	Rattus norvegicus	181-190	
28991371-3	2018	They increased the concentrations of serum insulin, C-peptide and Glp-1 (P < 0.05) by improving the STZ-induced damage of islet beta-cells and increasing their insulin expression (P < 0.05).	Streptozocin	103-106	insulin 2	Rattus norvegicus	52-61	
30408473-5	2019	Combined treatment of HFD and STZ (20 mg/kg) in the DCRD manner were significantly induced late-stage diabetic complication with sustained hyperglycaemia, no mortality, increased HbA1c and dyslipidaemia, reduced insulin, C-peptide and beta cells.	Streptozocin	30-33	insulin 2	Rattus norvegicus	221-230	
31185481-3	2019	METHODS: Rats were either injected once with 65 mg/kg streptozotocin (STZ) before being sacrificed after 8 weeks or were treated with a daily injection of insulin 2 days by STZ and continued until being sacrificed.	Streptozocin	173-176	insulin 2	Rattus norvegicus	155-164	
29517782-5	2018	The RCE treatment lowered blood glucose, and glycated and fetal hemoglobin concentrations and improved glucose tolerance as well as considerably raised serum insulin, proinsulin and C-peptide levels in streptozotocin-treated rats.	Streptozocin	202-216	insulin 2	Rattus norvegicus	182-191	
23105684-1	2007	The objective of this study is to induce experimental diabetes mellitus by Streptozotocin in normal adult Wistar rats via comparison of changes in body weight, consumption of food and water, volume of urine and levels of glucose, insulin and C-peptide in serum, between normal and diabetic rats.	Streptozocin	75-89	insulin 2	Rattus norvegicus	242-251	
25560570-4	2015	RESULTS: STZ-induced diabetes was associated with body weight reduction, hyperglycemia, overproduction of glycated hemoglobin, as well as decline in serum insulin, C-peptide, and insulin like growth factor-I.	Streptozocin	9-12	insulin 2	Rattus norvegicus	164-207	
25298622-1	2014	The objective of this study is to induce experimental diabetes mellitus by streptozotocin in normal adult Wistar rats via comparison of changes in body weight, consumption of food, volume of water, urine and levels of glucose, insulin and C-peptide in serum, between normal and diabetic rats.	Streptozocin	75-89	insulin 2	Rattus norvegicus	239-248	
21618400-3	2011	METHODS: The effect of C-peptide incubation (2 h) on gene expression was investigated in freshly isolated proximal tubular cells from streptozotocin-diabetic Sprague-Dawley rats using global gene expression profiling and real-time quantitative polymerase chain reaction.	Streptozocin	134-148	insulin 2	Rattus norvegicus	23-32	
21106770-10	2010	In conclusion, C-peptide administration to STZ-diabetic rats for 8 weeks results in the inhibition of diabetes-induced expansion of the mesangial matrix.	Streptozocin	43-46	insulin 2	Rattus norvegicus	15-24	
16799398-14	2006	CONCLUSIONS: C-peptide administration in replacement dose to streptozotocin diabetic rats induces weight gain regardless hyperglycaemia or glycosuria.	Streptozocin	61-75	insulin 2	Rattus norvegicus	13-22	
17103462-0	2007	The C-peptide fragment EVARQ reduces glomerular hyperfiltration in streptozotocin-induced diabetic rats.	Streptozocin	67-81	insulin 2	Rattus norvegicus	4-13	
12525088-4	2001	The results showed that: (1) blood glucose of STZ diabetic rats was higher, serum insulin, C-peptide and leptin level were lower than that of normal rats; (2) blood glucose was decreased, and blood insulin and C-peptide were increased in exercised STZ diabetic group.	Streptozocin	46-49	insulin 2	Rattus norvegicus	210-219	
8800366-0	1996	Effect of C-peptide administration on whole body glucose utilization in STZ-induced diabetic rats.	Streptozocin	72-75	insulin 2	Rattus norvegicus	10-19	
8800366-8	1996	These results thus demonstrate that C-peptide has the capacity to increase glucose utilization in STZ-induced diabetic rats.	Streptozocin	98-101	insulin 2	Rattus norvegicus	36-45	
16101290-3	2005	Here we show that chemically synthesized INS2 has biological activity that significantly enhances insulin reduction of hyperglycemia in streptozotocin diabetic rats.	Streptozocin	136-150	insulin 2	Rattus norvegicus	41-45	
2973549-3	1988	The pups born to the streptozotocin-treated mothers had higher birth weight, pancreatic insulin content, plasma insulin, and C-peptide concentrations compared with pups born to control mothers.	Streptozocin	21-35	insulin 2	Rattus norvegicus	77-134