PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25801006-2 2015 We hypothesized that angiotensin-(1-9) [Ang-(1-9)] attenuates cardiomyopathy in streptozotocin (STZ)-induced diabetic rats. Streptozocin 80-94 angiogenin Rattus norvegicus 40-48 32679026-2 2021 METHOD: Thirty-four male Wistar rats were randomly divided into 3 groups: control group, which was fed standard diet, DM group, high-fat diet and injected with streptozotocin, and Ang-(1-7) group receiving injection of streptozotocin followed by Ang-(1-7) treatment. Streptozocin 219-233 angiogenin Rattus norvegicus 180-188 32679026-9 2021 CONCLUSION: Ang-(1-7) protects against streptozotocin-induced DM through the improvement of insulin secretion, insulin resistance and islet fibrosis, which is associated with the upregulation of Pdx1, Glut2 and Gk expressions. Streptozocin 39-53 angiogenin Rattus norvegicus 12-20 26536590-4 2015 Streptozotocin-induced diabetic rats were chronically treated with Ang-(1-7) or AG825, a selective ErbB2 inhibitor, for 4 weeks and mechanistic studies performed in the isolated mesenteric vasculature bed as well as in cultured vascular smooth muscle cells (VSMCs). Streptozocin 0-14 angiogenin Rattus norvegicus 67-75 25801006-2 2015 We hypothesized that angiotensin-(1-9) [Ang-(1-9)] attenuates cardiomyopathy in streptozotocin (STZ)-induced diabetic rats. Streptozocin 96-99 angiogenin Rattus norvegicus 40-48 25801006-5 2015 Although Ang-(1-9) treatment did not affect blood glucose and insulin levels, it significantly attenuated cardiac hypertrophy, reduced cardiac fibrosis and improved ventricular function in STZ-induced diabetic rats. Streptozocin 189-192 angiogenin Rattus norvegicus 9-17 25801006-10 2015 Finally, it was found that Ang-(1-9) treatment could alleviate STZ-induced cardiomyopathy in a dose-dependent manner. Streptozocin 63-66 angiogenin Rattus norvegicus 27-35 25801006-11 2015 In conclusions, Ang-(1-9) attenuates cardiac dysfunction in STZ-induced diabetic rats. Streptozocin 60-63 angiogenin Rattus norvegicus 16-24 25075768-7 2015 Thus, Ang(1-7) ameliorated streptozotocin-induced diabetic renal injury. Streptozocin 27-41 angiogenin Rattus norvegicus 6-13 25576844-1 2015 The aim of this study is to determine the antidiabetic activity of Ang-(1-7), an important component of the renin-angiotensin system, in a rat model of streptozotocin (STZ)-induced type 2 diabetes mellitus (DM). Streptozocin 152-166 angiogenin Rattus norvegicus 67-70 25576844-1 2015 The aim of this study is to determine the antidiabetic activity of Ang-(1-7), an important component of the renin-angiotensin system, in a rat model of streptozotocin (STZ)-induced type 2 diabetes mellitus (DM). Streptozocin 168-171 angiogenin Rattus norvegicus 67-70 25576844-10 2015 Taken together, Ang-(1-7) protects against STZ-induced DM through improvement of insulin resistance, insulin secretion, and pancreatic beta cell survival, which is associated with reduction of iNOS expression and alteration of the Bcl-2 family. Streptozocin 43-46 angiogenin Rattus norvegicus 16-19 15701818-9 2005 Exogenous ANG1-9 in glomerular extracts was converted into ANG II, this conversion being significantly higher in STZ rats than in control rats. Streptozocin 113-116 angiogenin Rattus norvegicus 10-16 15354084-2 2004 In this study, we investigated alterations of the gene expression of Ang-1 and Ang-2 in the retinas of streptozotocin (STZ) induced diabetic rats. Streptozocin 103-117 angiogenin Rattus norvegicus 69-74 15354084-2 2004 In this study, we investigated alterations of the gene expression of Ang-1 and Ang-2 in the retinas of streptozotocin (STZ) induced diabetic rats. Streptozocin 119-122 angiogenin Rattus norvegicus 69-74 15354084-6 2004 In contrast, Ang-1 and Tie2 mRNA expression was stable at every timepoint during 6 months of STZ induced diabetes. Streptozocin 93-96 angiogenin Rattus norvegicus 13-18 15539791-11 2004 The Ang II-infused STZ-diabetic rat is an excellent model to study the deleterious glomerular effects of hypertension on diabetes independent of genetic traits. Streptozocin 19-22 angiogenin Rattus norvegicus 4-7