PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7939172-6 1994 Taken together, these results show that alteration in sugar chain structures of hCG reflect the advanced stage of cervical cancer. Sugars 54-59 hypertrichosis 2 (generalised, congenital) Homo sapiens 80-83 22455390-3 2012 hCG is the most acidic glycoprotein containing the highest proportion of sugars. Sugars 73-79 hypertrichosis 2 (generalised, congenital) Homo sapiens 0-3 9833611-17 1998 The detection of the alteration in hCG sugar chains is useful for biochemical diagnosis of choriocarcinoma. Sugars 39-44 hypertrichosis 2 (generalised, congenital) Homo sapiens 35-38 8206328-7 1994 As these alpha subunit favoring antibodies easily recognized DG-hCG but not the intact hCG configuration, we suggest that loss of sugars in alpha and beta subunits of DG-hCG was responsible for these alterations. Sugars 130-136 hypertrichosis 2 (generalised, congenital) Homo sapiens 64-67 7939172-1 1994 Human chorionic gonadotropin (hCG) is a glycoprotein of which sugar chains are considered to show structural changes with malignancy. Sugars 62-67 hypertrichosis 2 (generalised, congenital) Homo sapiens 30-33 7939172-2 1994 To study the sugar chain heterogeneity of urinary hCG in patients with gynecological disease, we employed serial lectin affinity chromatography (LAC) using concanavalin A (Con A) and phytohemagglutinin-E (PHA-E) which can separate N-glycoside-linked sugar chains, and Jacalin lectin which is specific for O-glycoside-linked sugar chains. Sugars 13-18 hypertrichosis 2 (generalised, congenital) Homo sapiens 50-53 29645229-17 1998 The detection of the alteration in hCG sugar chains is useful for biochemical diagnosis of choriocarcinoma. Sugars 39-44 hypertrichosis 2 (generalised, congenital) Homo sapiens 35-38 3093007-3 1986 The concentrate was then specifically retained on an affinity gel with human choriogonadotropin (hCG) covalently grafted by its sugar moiety. Sugars 128-133 hypertrichosis 2 (generalised, congenital) Homo sapiens 97-100 2981077-11 1985 These results indicate that the enhanced LH receptor affinity caused by removal of the sugar moieties from hCG is accompanied by a relatively greater increase in FSH receptor affinity, and that deglycosylated hCG acts as a partial agonist with the ability to modify granulosa cell responses to both LH and FSH. Sugars 87-92 hypertrichosis 2 (generalised, congenital) Homo sapiens 107-110 217642-1 1978 Removal of the sugar residues internal to sialic acid from the hCG molecule markedly diminished the ability of hCG to stimulate cAMP accumulation by porcine granulosa cells during a 30-min incubation period. Sugars 15-20 hypertrichosis 2 (generalised, congenital) Homo sapiens 63-66 217642-1 1978 Removal of the sugar residues internal to sialic acid from the hCG molecule markedly diminished the ability of hCG to stimulate cAMP accumulation by porcine granulosa cells during a 30-min incubation period. Sugars 15-20 hypertrichosis 2 (generalised, congenital) Homo sapiens 111-114 217642-2 1978 At the same time, removal of sugars internal to sialic acid enabled the resulting hCG derivatives to become competitive inhibitors of hCG stimulation of cAMP accumulation. Sugars 29-35 hypertrichosis 2 (generalised, congenital) Homo sapiens 82-85 217642-2 1978 At the same time, removal of sugars internal to sialic acid enabled the resulting hCG derivatives to become competitive inhibitors of hCG stimulation of cAMP accumulation. Sugars 29-35 hypertrichosis 2 (generalised, congenital) Homo sapiens 134-137 217642-4 1978 It would, therefore, seem that hCG with sugars internal to sialic acid removed is able to bind to the receptor, but that, once bound, it is unable to activate adenylate cyclase. Sugars 40-46 hypertrichosis 2 (generalised, congenital) Homo sapiens 31-34