PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7477951-6 1995 In both CA1 and the dentate gyrus, pentylenetetrazol, 100 mg/kg, caused a trend towards increased excitability and caused a relatively mild loss of inhibition. Pentylenetetrazole 35-52 carbonic anhydrase 1 Rattus norvegicus 8-11 7955345-7 1994 PTZ given on day 1 resulted in a highly significant increase in the paired-pulse facilitation (PPF) of the population EPSP, but not of the population spike, in CA1 at all stimulus intensities. Pentylenetetrazole 0-3 carbonic anhydrase 1 Rattus norvegicus 160-163 7955345-9 1994 PTZ given on day 21 decreased PPF of the population EPSP and spike in CA1 and had no significant effect in the DG. Pentylenetetrazole 0-3 carbonic anhydrase 1 Rattus norvegicus 70-73 2886961-1 1987 Both pentylenetetrazole and normorphine increased CA1 pyramidal cell sensitivity to afferent stimulation and caused the appearance of synchronous afterpotentials (secondary spikes). Pentylenetetrazole 5-23 carbonic anhydrase 1 Rattus norvegicus 50-53 1279453-5 1992 Pentylenetetrazol kindling caused similar increases in neurokinin B mRNA expression in granule cells and in CA1 pyramidal cells, but not in hilar interneurons. Pentylenetetrazole 0-17 carbonic anhydrase 1 Rattus norvegicus 108-111 2272342-2 1990 PTZ induced spontaneous epileptiform field potential transients in areas CA3 and CA1, but not in the dentate gyrus. Pentylenetetrazole 0-3 carbonic anhydrase 1 Rattus norvegicus 81-84 2867507-2 1985 This compound reduced the number and size of the synaptically evoked population spikes recorded in the CA1 region in the presence of the convulsants, pentylenetetrazol, bicuculline or folate. Pentylenetetrazole 150-167 carbonic anhydrase 1 Rattus norvegicus 103-106 30607810-0 2019 Transient Switching of NMDA-Dependent Long-Term Synaptic Potentiation in CA3-CA1 Hippocampal Synapses to mGluR1-Dependent Potentiation After Pentylenetetrazole-Induced Acute Seizures in Young Rats. Pentylenetetrazole 141-159 carbonic anhydrase 1 Rattus norvegicus 77-80 33657439-0 2021 Pentylenetetrazol-induced seizures in adult rats are associated with plastic changes to the dendritic spines on hippocampal CA1 pyramidal neurons. Pentylenetetrazole 0-17 carbonic anhydrase 1 Rattus norvegicus 124-127 33657439-3 2021 In this study, a single PTZ dose (60 mg/kg) was administered to adult male rats and 30 min later, various neurobiological parameters were studied related to the transmission and modulation of excitatory impulses in pyramidal neurons of the hippocampal CA1 field. Pentylenetetrazole 24-27 carbonic anhydrase 1 Rattus norvegicus 252-255 32215948-5 2020 The recordings were obtained from hippocampal slices in the CA1 region at 25th day of PTZ application. Pentylenetetrazole 86-89 carbonic anhydrase 1 Rattus norvegicus 60-63 30607810-5 2019 The results revealed that LTP was strongly attenuated in the CA1 hippocampal area after PTZ-induced SE as compared with that in control animals. Pentylenetetrazole 88-91 carbonic anhydrase 1 Rattus norvegicus 61-64 29936569-8 2018 (3) The numbers of cells with structural and functional abnormalities in the hippocampus after PTZ-induced seizures decreased in the following order: CA1 > CA3b,c > hilus > dentate gyrus. Pentylenetetrazole 95-98 carbonic anhydrase 1 Rattus norvegicus 150-153 29306758-7 2018 The single injection of PTZ at a dose of 30mg/kg increased the expression of the alpha4 subunit in the DG, while at a dose of 55mg/kg, PTZ increased the expression of the alpha1 and alpha4 subunits in the DG and reduced expression of the gamma2 subunit in the CA1 and CA3 regions. Pentylenetetrazole 24-27 carbonic anhydrase 1 Rattus norvegicus 260-263 29306758-7 2018 The single injection of PTZ at a dose of 30mg/kg increased the expression of the alpha4 subunit in the DG, while at a dose of 55mg/kg, PTZ increased the expression of the alpha1 and alpha4 subunits in the DG and reduced expression of the gamma2 subunit in the CA1 and CA3 regions. Pentylenetetrazole 135-138 carbonic anhydrase 1 Rattus norvegicus 260-263 25782288-0 2014 [Morphofunctional changes in field CA1 of the rat hippocampus after pentylenetetrazole and lithium-pilocarpine induced seizures]. Pentylenetetrazole 68-86 carbonic anhydrase 1 Rattus norvegicus 35-38 26481164-0 2015 Chronic sodium salicylate administration enhances population spike long-term potentiation following a combination of theta frequency primed-burst stimulation and the transient application of pentylenetetrazol in rat CA1 hippocampal neurons. Pentylenetetrazole 191-208 carbonic anhydrase 1 Rattus norvegicus 216-219 25657807-9 2014 PTZ-induced kindling indicates a significant decrease in the number of pyramidal neurons and dendritic spines in hippocampal region cornu ammonis (CA1). Pentylenetetrazole 0-3 carbonic anhydrase 1 Rattus norvegicus 147-150 24843185-6 2014 Further Nissl staining revealed that resveratrol significantly reduced pentylenetetrazole-induced death of neurons in the CA1 and CA3 regions of the hippocampus. Pentylenetetrazole 71-89 carbonic anhydrase 1 Rattus norvegicus 122-125 23833560-10 2013 The numbers of dark neurons in CA1 area of OVX-PTZ-T group was higher than OVX-PTZ group (p<0.05) compared to control, the numbers of dark neurons in CA3 area showed a significant increase in Sham-PTZ and OVX-PTZ group (p<0.05 and p<0.01 respectively). Pentylenetetrazole 47-50 carbonic anhydrase 1 Rattus norvegicus 31-34 23550026-2 2013 Here, we compared the ability of PTZ via the intravenous and subcutaneous routes to evoke progressive epileptiform activity in the hippocampal CA1 neurons of anesthetized rats. Pentylenetetrazole 33-36 carbonic anhydrase 1 Rattus norvegicus 143-146 23550026-5 2013 However, when PTZ was given subcutaneously, it induced a slowly-developing pattern of epileptogenesis; first, generating multiple population-spike peaks, then spontaneous interictal discharge-like spike, leading to the final ictal discharge-like, highly synchronized bursting fi ring in the CA1 pyramidal layer of the hippocampus. Pentylenetetrazole 14-17 carbonic anhydrase 1 Rattus norvegicus 291-294 23530507-5 2013 Rats with repetitive PTZ-induced seizures demonstrated lower phenytoin-induced anticonvulsant effects, increased number of DiBAC4(3) fluorescence cells and P-gp overexpression in hippocampus and neocortex, as well as augmentation of the induced fEPSP in CA1 field. Pentylenetetrazole 21-24 carbonic anhydrase 1 Rattus norvegicus 254-257 21269843-0 2011 Epileptiform response of CA1 neurones to convulsant stimulation by cyclothiazide, kainic acid and pentylenetetrazol in anaesthetized rats. Pentylenetetrazole 98-115 carbonic anhydrase 1 Rattus norvegicus 25-28 22395141-9 2011 RESULTS: The number of PSA-NCAM positive cells in the CA1, CA3, and DG fields of pup"s hippocampus, which was obtained from mothers who experienced PTZ injection during pregnancy, was decreased approximately 2.6 (P = 0.001), 2 (P = 0.001), and 2.1 (P = 0.001) times compared with non-PTZ treated maternal groups, respectively. Pentylenetetrazole 148-151 carbonic anhydrase 1 Rattus norvegicus 54-57 20665697-1 2011 The impact of theta patterning of the stimulation on the kindling effects of pentylenetetrazol (PTZ) was studied in rat hippocampus area CA1 in vitro. Pentylenetetrazole 77-94 carbonic anhydrase 1 Rattus norvegicus 137-140 20665697-1 2011 The impact of theta patterning of the stimulation on the kindling effects of pentylenetetrazol (PTZ) was studied in rat hippocampus area CA1 in vitro. Pentylenetetrazole 96-99 carbonic anhydrase 1 Rattus norvegicus 137-140 16841155-2 2006 Sequences of 11 injections of pentylenetetrazol significantly decreased the number of normal neurons in hippocampal field CA1 in SS rats, this effect being seen in both hippocampal field CA1 and the dentate fascia in ST rats. Pentylenetetrazole 30-47 carbonic anhydrase 1 Rattus norvegicus 122-125 19183220-0 2009 Morphine dependence increases the response to a brief pentylenetetrazol administration in rat hippocampal CA1 in vitro. Pentylenetetrazole 54-71 carbonic anhydrase 1 Rattus norvegicus 106-109 19183220-1 2009 PURPOSE: Herein we used electrophysiologic approaches in hippocampal area CA1 to estimate how morphine treatment alters the pentylenetetrazol (PTZ) effects. Pentylenetetrazole 124-141 carbonic anhydrase 1 Rattus norvegicus 74-77 19183220-5 2009 RESULTS: Morphine dependence increased a PTZ-induced long-term potentiation (LTP) of the population spike in CA1 in vitro. Pentylenetetrazole 41-44 carbonic anhydrase 1 Rattus norvegicus 109-112 19183220-8 2009 However, PTZ-induced multiple population spikes (epileptiform activity) in CA1 was not blocked by naloxone. Pentylenetetrazole 9-12 carbonic anhydrase 1 Rattus norvegicus 75-78 19183220-9 2009 DISCUSSION: It is concluded that dependence on morphine enhances PTZ-induced plastic and epileptic changes in CA1 excitability. Pentylenetetrazole 65-68 carbonic anhydrase 1 Rattus norvegicus 110-113 17900816-2 2007 This study was conducted in pentylenetetrazol (PTZ) -kindled rats to examine offsetting of aberrations associated with seizure proneness in hippocampus area CA1 by theta pulse stimulation (TPS: 5 Hz trains for 3 min) -induced activity pattern. Pentylenetetrazole 28-45 carbonic anhydrase 1 Rattus norvegicus 157-160 16841155-2 2006 Sequences of 11 injections of pentylenetetrazol significantly decreased the number of normal neurons in hippocampal field CA1 in SS rats, this effect being seen in both hippocampal field CA1 and the dentate fascia in ST rats. Pentylenetetrazole 30-47 carbonic anhydrase 1 Rattus norvegicus 187-190 16206620-2 2005 The number of normal neurons was significantly decreased in CA1 subfield of TR hippocampus after 11 injections of PTZ, while in SR neuronal cell loss was evident in CA1 and fascia dentata. Pentylenetetrazole 114-117 carbonic anhydrase 1 Rattus norvegicus 60-63 17704832-7 2006 In the acute PTZ-induced convulsive rats, the number of KChIP1-postive cells was significantly increased especially in the regions of CA1 and CA3 (P < 0.05); whereas the chronic PTZ-induced convulsive rats were found no changes. Pentylenetetrazole 13-16 carbonic anhydrase 1 Rattus norvegicus 134-137 21186563-0 2006 [Propofol antagonizes the effects of pentylenetetrazole on action potentials or synaptic transmission in hippocampal CA1 neurons of rats]. Pentylenetetrazole 37-55 carbonic anhydrase 1 Rattus norvegicus 117-120 16242239-4 2006 PTZ-kindling in rats induced moderate neuronal cell loss in hippocampal fields CA1, CA 3, CA 4, and dentate gyrus. Pentylenetetrazole 0-3 carbonic anhydrase 1 Rattus norvegicus 79-82 16206620-4 2005 After 21 injections of PTZ, the decrease in normal neuron number was revealed in CA1 subfield of both TR and SR, while the number of damaged neurons was above the control level in hippocampal subfields CA1 and CA4 in TR only. Pentylenetetrazole 23-26 carbonic anhydrase 1 Rattus norvegicus 81-84 16206620-4 2005 After 21 injections of PTZ, the decrease in normal neuron number was revealed in CA1 subfield of both TR and SR, while the number of damaged neurons was above the control level in hippocampal subfields CA1 and CA4 in TR only. Pentylenetetrazole 23-26 carbonic anhydrase 1 Rattus norvegicus 202-205 10986330-0 2000 Primed-burst potentiation occludes the potentiation phenomenon and enhances the epileptiform activity induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices. Pentylenetetrazole 123-140 carbonic anhydrase 1 Rattus norvegicus 148-151 12923811-0 2003 Reversal of pentylenetetrazol-induced potentiation phenomenon by theta pulse stimulation in the CA1 region of rat hippocampal slices. Pentylenetetrazole 12-29 carbonic anhydrase 1 Rattus norvegicus 96-99 12923811-1 2003 The effect of theta pulse stimulation (TPS) on pentylenetetrazol (PTZ)-induced long-term potentiation of population spikes was studied in the CA1 region of rat hippocampal slices. Pentylenetetrazole 47-64 carbonic anhydrase 1 Rattus norvegicus 142-145 12480172-0 2003 Contribution of ionotropic glutamate receptors and voltage-dependent calcium channels to the potentiation phenomenon induced by transient pentylenetetrazol in the CA1 region of rat hippocampal slices. Pentylenetetrazole 138-155 carbonic anhydrase 1 Rattus norvegicus 163-166 12480172-1 2003 The role of ionotropic glutamate receptors and voltage-dependent calcium channels (VDCCs) in potentiation phenomenon and epileptic activity induced by a transient pentylenetetrazol (PTZ) application in the CA1 region of rat hippocampal slices was investigated. Pentylenetetrazole 163-180 carbonic anhydrase 1 Rattus norvegicus 206-209 12480172-1 2003 The role of ionotropic glutamate receptors and voltage-dependent calcium channels (VDCCs) in potentiation phenomenon and epileptic activity induced by a transient pentylenetetrazol (PTZ) application in the CA1 region of rat hippocampal slices was investigated. Pentylenetetrazole 182-185 carbonic anhydrase 1 Rattus norvegicus 206-209 12419525-0 2002 Cysteamine pre-treatment reduces pentylenetetrazol-induced plasticity and epileptiform discharge in the CA1 region of rat hippocampal slices. Pentylenetetrazole 33-50 carbonic anhydrase 1 Rattus norvegicus 104-107 12419525-1 2002 The effects of prior treatment of cysteamine, a somatostatin inhibitor, on pentylenetetrazol (PTZ) induced epileptic and plastic changes in CA1 excitability were examined. Pentylenetetrazole 75-92 carbonic anhydrase 1 Rattus norvegicus 140-143 12419525-7 2002 It is concluded that somatostatin may be involved in PTZ-induced epileptic and plastic changes in CA1 excitability. Pentylenetetrazole 53-56 carbonic anhydrase 1 Rattus norvegicus 98-101 11292451-0 2001 Differential effects of pentylenetetrazol-kindling on long-term potentiation of population excitatory postsynaptic potentials and population spikes in the CA1 region of rat hippocampus. Pentylenetetrazole 24-41 carbonic anhydrase 1 Rattus norvegicus 155-158 10986330-1 2000 The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Pentylenetetrazole 15-32 carbonic anhydrase 1 Rattus norvegicus 115-118 10986330-1 2000 The effects of pentylenetetrazol (PTZ) following induction of long-term potentiation (LTP) on population spikes in CA1 of hippocampal slices were investigated. Pentylenetetrazole 34-37 carbonic anhydrase 1 Rattus norvegicus 115-118 9284490-0 1997 Pentylenetetrazol kindling changes the ability to induce potentiation phenomena in the hippocampal CA1 region. Pentylenetetrazole 0-17 carbonic anhydrase 1 Rattus norvegicus 99-102 9590559-8 1998 After metrazol-induced seizures, Fos-positive cells were present in CA1 heterotopias, the only hippocampal region to be activated with the neocortex. Pentylenetetrazole 6-14 carbonic anhydrase 1 Rattus norvegicus 68-71 9518693-3 1998 Pentylenetetrazol kindling decreased the hippocampal NMDAR1 mRNA level after 3 and 24 h; lowered the GluR2 flip level and elevated the flop mRNA one in the CA1 field and dentate gyrus after 3 and 24 h, respectively. Pentylenetetrazole 0-17 carbonic anhydrase 1 Rattus norvegicus 156-159 9203537-1 1997 The early and long-lasting effects of pentylenetetrazol-kindling on hippocampal CA1 synaptic transmission were investigated. Pentylenetetrazole 38-55 carbonic anhydrase 1 Rattus norvegicus 80-83 9203537-0 1997 Examination of persistent effects of repeated administration of pentylenetetrazol on rat hippocampal CA1: evidence from in vitro study on hippocampal slices. Pentylenetetrazole 64-81 carbonic anhydrase 1 Rattus norvegicus 101-104 9203537-8 1997 Our results suggest that pentylenetetrazol-kindling is accompanied by enhanced excitability and a reduction of paired-pulse inhibition in hippocampal CA1. Pentylenetetrazole 25-42 carbonic anhydrase 1 Rattus norvegicus 150-153 8949936-0 1996 Repeated administration of pentylenetetrazol alters susceptibility of rat hippocampus to primed-burst stimulation: evidence from in vitro study on CA1 of hippocampal slices. Pentylenetetrazole 27-44 carbonic anhydrase 1 Rattus norvegicus 147-150