PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
2909383-5	1989	The range of values for individual cells was estimated by comparing the coefficient of variation of the test sample with that obtained when nigericin was used to reduce all cells to the pHi of the calibration buffer.	Nigericin	140-149	glucose-6-phosphate isomerase 1	Mus musculus	186-189	
8606009-2	1996	The pHi of mouse cauda epididymal sperm was determined from the fluorescence excitation ratio of 2,7-bis(carboxyethyl)-5(6)-carboxyfluorescein and calibrated with nigericin and elevated external [K+].	Nigericin	163-172	glucose-6-phosphate isomerase 1	Mus musculus	4-7	
8645575-2	1996	Previous studies have shown that drugs that acidify cells at lower pHe such as nigericin, used alone or with agents that inhibit the regulation of pHi, have toxicity to cultured cells at pHe < 6.5 in short-term exposure; these agents also lead to modest anti-tumour effects in mice when given acutely.	Nigericin	79-88	glucose-6-phosphate isomerase 1	Mus musculus	147-150	
10627304-4	2000	The change in intracellular pH (pH(i)) resulting from the change in pH(0) seems to be a prerequisite for the motility decrease since other means to decrease pH(i), namely Na(+)-free solution (in the absence of HCO(-)(3)) and nigericin-containing solution, mimicked the extracellular acidification.	Nigericin	225-234	glucose-6-phosphate isomerase 1	Mus musculus	32-37	
7881914-5	1994	The relation between the ratio of emitted maxima and the extracellular pH (pHo) in the presence of nigericin allowed a calibration procedure to determine the intracellular pH (pHi).	Nigericin	99-108	glucose-6-phosphate isomerase 1	Mus musculus	176-179	
7829226-1	1995	Nigericin is an ionophore which permits the influx of H+ ions into cells down a concentration gradient, thus reducing intracellular pH (pHi) when extracellular pH is low.	Nigericin	0-9	glucose-6-phosphate isomerase 1	Mus musculus	136-139	
8554515-5	1995	Recovery of pHi in L1210 cells after a nigericin- or NH4(+)-mediated acid load in HCO3(-)-free buffers was mediated by Na+/H+ antiporter activity, in addition to a minor Na(+)-independent and amiloride-insensitive pathway.	Nigericin	39-48	glucose-6-phosphate isomerase 1	Mus musculus	12-15	
8328315-5	1993	Clamping pHi to known values with 10 microM nigericin, a potassium proton ionophore, also influenced Cai: acid pHi lowered Cai, whereas alkaline pHi increased it.	Nigericin	44-53	glucose-6-phosphate isomerase 1	Mus musculus	9-12	
7865901-2	1994	Cell killing can be achieved in an acidic environment in tissue culture by nigericin, which acidifies cells by transporting H+ from the extracellular space into the cytoplasm; this cell killing can be enhanced when used with 5-(N-ethyl-N-isopropyl)amiloride (EIPA), a potent inhibitor of membrane-based Na+/H+ exchange, which plays a major role in the regulation of pHi (R. P. Maidorn; E. J. Cragoe; I. F. Tannock, Br.	Nigericin	75-84	glucose-6-phosphate isomerase 1	Mus musculus	366-369	
8253856-8	1993	In subsequent studies, pHi was independently manipulated using the ionophore nigericin.	Nigericin	77-86	glucose-6-phosphate isomerase 1	Mus musculus	23-26	
8328315-5	1993	Clamping pHi to known values with 10 microM nigericin, a potassium proton ionophore, also influenced Cai: acid pHi lowered Cai, whereas alkaline pHi increased it.	Nigericin	44-53	glucose-6-phosphate isomerase 1	Mus musculus	111-114	
8328315-5	1993	Clamping pHi to known values with 10 microM nigericin, a potassium proton ionophore, also influenced Cai: acid pHi lowered Cai, whereas alkaline pHi increased it.	Nigericin	44-53	glucose-6-phosphate isomerase 1	Mus musculus	111-114	
1503904-17	1992	Our results show that the combination of nigericin and hydralazine (with or without amiloride) can kill cells in rodent solid tumours and that cell killing is associated with a reduction in the mean pHi of tumour cells.	Nigericin	41-50	glucose-6-phosphate isomerase 1	Mus musculus	199-202