PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21056902-2 2011 Inhibition of guanylyl cyclase (GC) with either methylene blue or ODQ slightly inhibited the ability of submaximal concentrations of thrombin to increase [Ca(2+)](i) which suggests that a small portion of the thrombin mediated increase in [Ca(2+)](i) was due to an increase in NO and subsequent increase in cGMP and activation of cGMP dependent protein kinase (cGPK). 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 66-69 coagulation factor II, thrombin Homo sapiens 133-141 21056902-5 2011 In platelets GEA3162 had no effect to increase [Ca(2+)](i) however it inhibited the ability of thrombin to increase [Ca(2+)](i) and this effect was reversed by ODQ. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 160-163 coagulation factor II, thrombin Homo sapiens 95-103 19895807-9 2010 In thrombin-activated platelets, ODQ fully prevented the SIN-1-induced cGMP elevations, but only partly prevented the adhesion inhibition. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 33-36 coagulation factor II, thrombin Homo sapiens 3-11 23144808-6 2012 RESULTS: BAY 60-2770 (0.001-10 microM) produced significant inhibition of collagen (2 microg/ml)- and thrombin (0.1 U/ml)-induced platelet aggregation that was markedly potentiated by the sGC inhibitor ODQ (10 microM). 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 202-205 coagulation factor II, thrombin Homo sapiens 102-110 23144808-11 2012 Collagen- and thrombin-induced alpha(IIb)beta(3) activation was markedly inhibited by BAY 60-2770 that was further inhibited by ODQ. 1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one 128-131 coagulation factor II, thrombin Homo sapiens 14-22