PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25046820-5	2014	The 7-NI- or ODQ-induced effect was reversed by premicroinjection of the sGC activator YC-1 or the PKG activator 8-Br-cGMP in the NAc shell.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	13-16	protein kinase cGMP-dependent 1	Homo sapiens	99-102	
15312987-12	2004	In addition, cGK and GC inhibition by KT-5823 and ODQ significantly attenuated light-induced phase shifts at CT 18.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	50-53	protein kinase cGMP-dependent 1	Homo sapiens	13-16	
10615072-7	2000	TNF for 0.5 h induced an increase in PKG activity that was prevented by aminoguanidine, ODQ, KT5823, and 8-bromo-cGMP-thioate; however, SOD had no effect.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	88-91	protein kinase cGMP-dependent 1	Homo sapiens	37-40	
10615072-8	2000	The PKG agonist 8-bromo-cGMP (100 microM), when given alone, increased PKG activity but induced significant DNA-binding activity of AP-1 only when given in the ODQ + TNF Group.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	160-163	protein kinase cGMP-dependent 1	Homo sapiens	4-7	
26344105-5	2015	This carbachol-induced inhibitory effect on Ca(2+) oscillations in myocytes and pericytes was reversed by ODQ, an inhibitor of soluble guanylyl cyclase (sGC) and by Rp-8-pCPT-cGMPS, an inhibitor of protein kinase G (PKG).	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	106-109	protein kinase cGMP-dependent 1	Homo sapiens	198-214	
26344105-5	2015	This carbachol-induced inhibitory effect on Ca(2+) oscillations in myocytes and pericytes was reversed by ODQ, an inhibitor of soluble guanylyl cyclase (sGC) and by Rp-8-pCPT-cGMPS, an inhibitor of protein kinase G (PKG).	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	106-109	protein kinase cGMP-dependent 1	Homo sapiens	216-219	
33877557-8	2021	The enhancing effects of cGMP and PKG levels by glabridin were abolished by ODQ and KT5823.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	76-79	protein kinase cGMP-dependent 1	Homo sapiens	34-37	
31393950-6	2019	Treatment with calphostin C, PTIO, ODQ or KT5823, respective inhibitors of PKC, NO, soluble guanylate cyclase and PKG, abrogated completely the effect of epinephrine and PGE2, suggesting an involvement of these mediators.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	35-38	protein kinase cGMP-dependent 1	Homo sapiens	114-117	
25139746-6	2014	The inhibitory actions of SNAP and 8-Br-cGMP on 11,12-EET-induced membrane hyperpolarization and vascular relaxation were reversed by hydroxocobalamin, an NO scavenger; ODQ, a guanylyl cyclase inhibitor; and KT5823, a protein kinase G (PKG) inhibitor.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	169-172	protein kinase cGMP-dependent 1	Homo sapiens	218-234	
25139746-6	2014	The inhibitory actions of SNAP and 8-Br-cGMP on 11,12-EET-induced membrane hyperpolarization and vascular relaxation were reversed by hydroxocobalamin, an NO scavenger; ODQ, a guanylyl cyclase inhibitor; and KT5823, a protein kinase G (PKG) inhibitor.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	169-172	protein kinase cGMP-dependent 1	Homo sapiens	236-239	
23470198-8	2013	The inhibitory effect of complex I in the carrageenin-induced hyperalgesia, MPO activity and formalin was prevented by the treatment with ODQ, KT5823 and glybenclamide, indicating that complex I inhibits inflammatory hyperalgesia by activating the cGMP/PKG/ATP-sensitive potassium channel signaling pathway.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	138-141	protein kinase cGMP-dependent 1	Homo sapiens	253-256	
23958999-5	2013	This effect was mediated by the activation of soluble guanylyl cyclase and PKG, since it was blocked by the respective enzyme inhibitors ODQ or LY83583 and KT5823, as well as by transduction with shRNA lentiviruses coding PKGII shRNA, and mimicked by the respective enzyme activators YC-1 and 8-Bromo cyclic GMP, and also by the cyclic GMP phosphodiesterase inhibitor zaprinast.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	137-140	protein kinase cGMP-dependent 1	Homo sapiens	75-78	
22771630-7	2012	ODQ and KT5823, respective inhibitors of guanylate cyclase and cyclic GMP-dependent kinase (PKG), strongly reversed andrographolide-mediated inhibition of platelet aggregation, relative [Ca(2+)]i mobilization, and IKKbeta, and p65 phosphorylation.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	0-3	protein kinase cGMP-dependent 1	Homo sapiens	92-95	
17377806-6	2007	The basal activity of PKG but not that of cyclic adenosine monophosphate-dependent protein kinase (PKA) was inhibited by nitro-L: -arginine, ODQ, or Rp-8-Br-PET-cGMPS.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	141-144	protein kinase cGMP-dependent 1	Homo sapiens	22-25	
21414799-5	2011	The effects of NO on NF-kappaB activity were cGMP-dependent because they were reversed in the presence of ODQ, the inhibitor of soluble guanylyl cyclase (sGC), and KT5823, the inhibitor of cGMP-dependent protein kinase (PKG).	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	106-109	protein kinase cGMP-dependent 1	Homo sapiens	220-223	
21328456-6	2011	ODQ (1H-[1,2,4]oxadiazolo[4,3,-a]quinoxalin-1-one), which blocks endogenous NO-induced activation of sGC and thus lowers endogenous cGMP/PKG activity, significantly elevated apoptotic levels by 2.5- and three-fold.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	0-3	protein kinase cGMP-dependent 1	Homo sapiens	137-140	
20043968-6	2010	ODQ (50 microM), a soluble guanylyl cyclase inhibitor that lowers cGMP/PKG activity, decreased serum-induced ser155 phosphorylation of Bad and induced apoptosis in N1E-115 cells.	1H-(1,2,3)oxadiazolo(4,4-a)quinoxalin-1-one	0-3	protein kinase cGMP-dependent 1	Homo sapiens	71-74