PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25108331-1	2014	The effects of detergents, trypsin, and bivalent metal ions on production of phosphatidic and lysophosphatidic acids by the action of phospholipase D (PLD) on lecithin and lysolecithin were studied.	Lysophospholipids	94-116	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	134-149	
25108331-1	2014	The effects of detergents, trypsin, and bivalent metal ions on production of phosphatidic and lysophosphatidic acids by the action of phospholipase D (PLD) on lecithin and lysolecithin were studied.	Lysophospholipids	94-116	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	151-154	
20335986-4	2010	A variety of chemical and enzymatic routes have been reported in the literature for the synthesis of LPLs: the enzymatic transformation of natural glycerophospholipids (GPLs) using regiospecific enzymes such as phospholipases A1 (PLA1), A2 (PLA2) phospholipase D (PLD) and different lipases, the coupling of enzymatic processes with chemical transformations, the complete chemical synthesis of LPLs starting from glycerol or derivatives.	Lysophospholipids	101-105	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	247-262	
20335986-4	2010	A variety of chemical and enzymatic routes have been reported in the literature for the synthesis of LPLs: the enzymatic transformation of natural glycerophospholipids (GPLs) using regiospecific enzymes such as phospholipases A1 (PLA1), A2 (PLA2) phospholipase D (PLD) and different lipases, the coupling of enzymatic processes with chemical transformations, the complete chemical synthesis of LPLs starting from glycerol or derivatives.	Lysophospholipids	101-105	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	264-267	
10828086-0	2000	Specific inhibition of rat brain phospholipase D by lysophospholipids.	Lysophospholipids	52-69	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	33-48	
10828086-3	2000	We herein report that the activity of partially purified rat brain PLD is inhibited by certain lysophospholipids, such as lysophosphatidylinositol, lysophosphatidylglycerol, and lysophosphatidylserine in a highly specific manner.	Lysophospholipids	95-112	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	67-70	
10828086-4	2000	Inhibition of PLD by lysophospholipids was dose-dependent: the concentration of lysophosphatidylinositol required for half-maximal inhibition was about 3 micrometer.	Lysophospholipids	21-38	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	14-17	
10828086-5	2000	An analysis of the enzyme-kinetics suggested that lysophospholipids act as non-competitive inhibitors of PLD activity.	Lysophospholipids	50-67	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	105-108	
10828086-7	2000	The inhibition of PLD by lysophospholipids, however, was not affected by the presence or absence of Arf or by an increase in PIP(2) concentration.	Lysophospholipids	25-42	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	18-21	
10828086-8	2000	A protein-binding assay suggested that lysophospholipids bind directly to PLD.	Lysophospholipids	39-56	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	74-77	
10828086-9	2000	These results indicate that the observed inhibition of PLD by lysophospholipids is due to their direct interaction rather than to an interaction between lysophospholipids and either Arf or PIP(2).	Lysophospholipids	62-79	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-58	
10828086-9	2000	These results indicate that the observed inhibition of PLD by lysophospholipids is due to their direct interaction rather than to an interaction between lysophospholipids and either Arf or PIP(2).	Lysophospholipids	153-170	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	55-58	
10828086-10	2000	The present study suggests that certain lysophospholipids are specific inhibitors of rat brain PLD in a cell-free system and may provide the new opportunities to investigate mechanisms by which PLD is regulated by lysophospholipids, presumably liberated by phospholipase A(2) activation, in mammalian cells.	Lysophospholipids	40-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	95-98	
10828086-10	2000	The present study suggests that certain lysophospholipids are specific inhibitors of rat brain PLD in a cell-free system and may provide the new opportunities to investigate mechanisms by which PLD is regulated by lysophospholipids, presumably liberated by phospholipase A(2) activation, in mammalian cells.	Lysophospholipids	40-57	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	194-197	
10828086-10	2000	The present study suggests that certain lysophospholipids are specific inhibitors of rat brain PLD in a cell-free system and may provide the new opportunities to investigate mechanisms by which PLD is regulated by lysophospholipids, presumably liberated by phospholipase A(2) activation, in mammalian cells.	Lysophospholipids	214-231	glycosylphosphatidylinositol specific phospholipase D1	Homo sapiens	194-197