PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10954752-0 2000 Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins. Arsenic Trioxide 23-28 zinc finger and BTB domain containing 16 Mus musculus 186-190 10954752-6 2000 Unexpectedly, therapeutic doses of RA and RA + As(2)O(3) can induce, both in vivo and in vitro, the degradation of either PML-RARalpha or PLZF-RARalpha proteins, suggesting that the maintenance of the leukemic phenotype depends on the continuous presence of the former, but not the latter. Arsenic Trioxide 47-56 zinc finger and BTB domain containing 16 Mus musculus 138-142