PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19364129-7 2009 Overexpression of 14-3-3zeta in MM cells attenuated ATO-induced cell death, whereas RNAi-based 14-3-3zeta knock-down or the inhibition of HSP90 enhanced tumor cell sensitivity to the ATO induction. Arsenic Trioxide 52-55 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens 18-28 19364129-7 2009 Overexpression of 14-3-3zeta in MM cells attenuated ATO-induced cell death, whereas RNAi-based 14-3-3zeta knock-down or the inhibition of HSP90 enhanced tumor cell sensitivity to the ATO induction. Arsenic Trioxide 183-186 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens 95-105 19364129-8 2009 These observations implicate 14-3-3zeta and HSP90 as potential molecular targets for drug intervention of multiple myeloma and thus improve our understanding on the mechanisms of antitumor activity of ATO. Arsenic Trioxide 201-204 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens 29-39