PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20605902-4 2010 Curcumin plus ATO or lonidamine stimulates typical events of the mitochondrial executioner pathway (Bax and Bid activation, cytochrome c release, X-linked inhibitor of apoptosis down-regulation, and caspase-9/-3 activation) and causes mitochondrial transmembrane potential dissipation, which nevertheless represents a late event in the apoptotic response. Arsenic Trioxide 14-17 X-linked inhibitor of apoptosis Homo sapiens 146-177 28187727-11 2017 We also found that ATO combined with CT reversed the upregulated expression of phosphorylated-STAT3Tyr705 stimulated by interleukin-6 and downregulated STAT3 direct target genes and the anti-apoptotic proteins Bcl-2, XIAP, and survivin but obviously upregulated the promoting apoptosis proteins Bak,.In vivo studies showed that ATO combined with CT decreased tumor growth. Arsenic Trioxide 19-22 X-linked inhibitor of apoptosis Homo sapiens 217-221 23178716-6 2013 Although EGFR or MAPK1 siRNA did not alter SnoN expression, As2O3-induced cleaved PARP was reduced together with increased XIAP. Arsenic Trioxide 60-65 X-linked inhibitor of apoptosis Homo sapiens 123-127 23041229-3 2012 Using ATO and HL60 as drug and cell models, respectively, we observed that 2-DG/ATO combination activates the mitochondrial apoptotic pathway, as indicated by Bid-, and Bax-regulated cytochrome c and Omi/HtrA2 release, XIAP down-regulation, and caspase-9/-3 pathway activation. Arsenic Trioxide 80-83 X-linked inhibitor of apoptosis Homo sapiens 219-223 21947421-7 2012 Furthermore, the co-treatment of oridonin and As2O3 induced ROS-mediated down-regulation of Akt and XIAP, and inhibition of NF-kappaB activation. Arsenic Trioxide 58-63 X-linked inhibitor of apoptosis Homo sapiens 112-116 19763917-0 2010 Arsenic trioxide induces apoptosis in NB-4, an acute promyelocytic leukemia cell line, through up-regulation of p73 via suppression of nuclear factor kappa B-mediated inhibition of p73 transcription and prevention of NF-kappaB-mediated induction of XIAP, cIAP2, BCL-XL and survivin. Arsenic Trioxide 0-16 X-linked inhibitor of apoptosis Homo sapiens 249-253 19763917-5 2010 Altogether, these issues show for the first time that ATO treatment could trammel cell growth and proliferation as well as induces apoptosis in NB-4 cells through induction of transcriptional levels of p73, TP53INP1, WNK2, lipocalin 2 as well as suppression of NF-kappaB-mediated induction of BCL-X(L), cIAP2, XIAP and survivin. Arsenic Trioxide 54-57 X-linked inhibitor of apoptosis Homo sapiens 310-314 11368438-4 2001 Combined treatment with As2O3 and STI-571 also resulted in greater reductions in the levels of Bcl-x(L), XIAP and Akt, and inhibition of Akt kinase activity. Arsenic Trioxide 24-29 X-linked inhibitor of apoptosis Homo sapiens 105-109 17537996-5 2007 Combination of ATO and dexamethasone resulted in increased Bad and rapid down-regulation of XIAP, while levels of the antiapoptotic regulator Mcl-1 remained unchanged. Arsenic Trioxide 15-18 X-linked inhibitor of apoptosis Homo sapiens 92-96 17537996-6 2007 Expression of dominant-active Akt, reduction of Bad expression by RNA interference, or overexpression of XIAP abrogated the sensitizing effect of ATO. Arsenic Trioxide 146-149 X-linked inhibitor of apoptosis Homo sapiens 105-109 18359480-3 2008 Co-treatment with ATO plus quercetin caused mitochondrial transmembrane potential dissipation, stimulated the mitochondrial apoptotic pathway, as indicated by cytochrome c and Omi/Htra2 release, XIAP and Bcl-X(L) down-regulation, and Bax activation, and caused caspase-8/Bid activation. Arsenic Trioxide 18-21 X-linked inhibitor of apoptosis Homo sapiens 195-199 21118639-0 2007 [The influence of arsenic trioxide combined with cisplatin on the growth and expression of X-linked inhibitor of apoptosis protein, XIAP of human non-small cell lung cancer cells]. Arsenic Trioxide 18-34 X-linked inhibitor of apoptosis Homo sapiens 132-136 21118639-3 2007 The aim of this study is to investigate the influence of arsenic trioxide (As2O3) injection combined with cisplatin (DDP) on the growth, apoptosis and XIAP mRNA of human non-small cell lung cancer cell lines. Arsenic Trioxide 57-73 X-linked inhibitor of apoptosis Homo sapiens 151-155 21118639-3 2007 The aim of this study is to investigate the influence of arsenic trioxide (As2O3) injection combined with cisplatin (DDP) on the growth, apoptosis and XIAP mRNA of human non-small cell lung cancer cell lines. Arsenic Trioxide 75-80 X-linked inhibitor of apoptosis Homo sapiens 151-155 21118639-6 2007 XIAP mRNA level of the cells was detected by RT-PCR before and after treatment of As2O3 combined with DDP or without DDP. Arsenic Trioxide 82-87 X-linked inhibitor of apoptosis Homo sapiens 0-4 21118639-7 2007 RESULTS: Compared to individual drug, As2O3 injection combined with DDP may obviously inhibit the proliferation of H460 cells, increase the apotosis rate of cells and strengthen inhibition of XIAP mRNA expression in cells. Arsenic Trioxide 38-43 X-linked inhibitor of apoptosis Homo sapiens 192-196 21118639-8 2007 CONCLUSIONS: As2O3 injection combined with DDP can significantly increase the chemosensitivity on human non-small cell lung cancer, and the mechanism may be related to its inhibition on the expression of XIAP. Arsenic Trioxide 13-18 X-linked inhibitor of apoptosis Homo sapiens 204-208