PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22959511-2	2012	Arsenic trioxide exposure led to much significant induction of apoptosis in K562/ADM cells than the parental K562 cells, and the chaperone proteins glucose-regulated protein 78, CHOP/GADD153, X-box binding protein-1 and caspase-12 were activated to varying degrees.	Arsenic Trioxide	0-16	X-box binding protein 1	Homo sapiens	192-215	
27895727-0	2016	Deficiency of SUMO-specific protease 1 induces arsenic trioxide-mediated apoptosis by regulating XBP1 activity in human acute promyelocytic leukemia.	Arsenic Trioxide	47-63	X-box binding protein 1	Homo sapiens	97-101	
27895727-7	2016	Taken together, these results revealed that the specific de-SUMOylation activity of SENP1 for XBP1 was involved in the ER stress-mediated apoptosis caused by As2O3 treatment in NB4 cells, thus providing insight into potential therapeutic targets for APL treatment via manipulating XBP1 signaling during ER stress by targeting SENP1.	Arsenic Trioxide	158-163	X-box binding protein 1	Homo sapiens	94-98	
27895727-7	2016	Taken together, these results revealed that the specific de-SUMOylation activity of SENP1 for XBP1 was involved in the ER stress-mediated apoptosis caused by As2O3 treatment in NB4 cells, thus providing insight into potential therapeutic targets for APL treatment via manipulating XBP1 signaling during ER stress by targeting SENP1.	Arsenic Trioxide	158-163	X-box binding protein 1	Homo sapiens	281-285	
19878647-5	2010	Several key players of the unfolded protein response, including GRP78, GADD153, ATF6, XBP1 and eIF2alpha are expressed and activated in PMNs treated with ATO or other ER stress inducers.	Arsenic Trioxide	154-157	X-box binding protein 1	Homo sapiens	86-90