PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 34319507-0 2021 Arsenic Trioxide Combining Leflunomide Activates Nrf2-ARE-HO-1 Signaling Pathway and Protects Heart Xenografts. Arsenic Trioxide 0-16 NFE2 like bZIP transcription factor 2 Rattus norvegicus 49-53 34319507-7 2021 RESULTS: Expression of Nrf2-ARE-HO-1 signaling pathway was upregulated in heart xenografts in rats treated with As2O3 plus leflunomide compared with control rats or rats treated with either drug alone (P<0.01), and this was accompanied by an increased Treg cells in the recipient rat spleen (P<0.01). Arsenic Trioxide 112-117 NFE2 like bZIP transcription factor 2 Rattus norvegicus 23-27 32146384-0 2020 Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-kappaB and Nrf2 pathways. Arsenic Trioxide 24-40 NFE2 like bZIP transcription factor 2 Rattus norvegicus 95-99 32920515-0 2020 Crocin ameliorates arsenic trioxide-induced cardiotoxicity via Keap1-Nrf2/HO-1 pathway: Reducing oxidative stress, inflammation, and apoptosis. Arsenic Trioxide 19-35 NFE2 like bZIP transcription factor 2 Rattus norvegicus 69-73 33000240-0 2020 Tannic acid attenuates hepatic oxidative stress, apoptosis and inflammation by activating the Keap1-Nrf2/ARE signaling pathway in arsenic trioxide-toxicated rats. Arsenic Trioxide 130-146 NFE2 like bZIP transcription factor 2 Rattus norvegicus 100-104 33000240-9 2020 The results demonstrated that TA has a protective effect on ATO-treated hepatic toxicity and that its underlying mechanism could be due to TA activation of the Keap1-Nrf2/ARE signaling pathway, to reduce oxidative stress, apoptosis and inflammation in ATO-intoxicated rats. Arsenic Trioxide 60-63 NFE2 like bZIP transcription factor 2 Rattus norvegicus 166-170 32920515-11 2020 Moreover, CRO caused an activation in nuclear factor erythroid-2 related factor 2, leading to enhanced Kelch-like ECH-associated protein 1, heme oxygenase-1 and nicotinamide adenine dinucleotide quinone dehydrogenase 1 expressions involved in Nrf2 signaling during ATO-induced cardiotoxicity. Arsenic Trioxide 265-268 NFE2 like bZIP transcription factor 2 Rattus norvegicus 38-81 32146384-12 2020 CONCLUSION: TA ameliorates ATO-induced nephrotoxicity, which is related to the inhibition of oxidative stress, inflammation and apoptosis, potentially through the NF-kappaB/Nrf2 pathway. Arsenic Trioxide 27-30 NFE2 like bZIP transcription factor 2 Rattus norvegicus 173-177 27561292-0 2017 Activation of the Nrf2 Signaling Pathway Involving KLF9 Plays a Critical Role in Allicin Resisting Against Arsenic Trioxide-Induced Hepatotoxicity in Rats. Arsenic Trioxide 107-123 NFE2 like bZIP transcription factor 2 Rattus norvegicus 18-22 31258454-0 2019 Gestational Arsenic Trioxide Exposure Acts as a Developing Neuroendocrine-Disruptor by Downregulating Nrf2/PPARgamma and Upregulating Caspase-3/NF-kB/Cox2/BAX/iNOS/ROS. Arsenic Trioxide 12-28 NFE2 like bZIP transcription factor 2 Rattus norvegicus 102-106 32546959-0 2020 Protective Effects of Crocetin on Arsenic Trioxide-Induced Hepatic Injury: Involvement of Suppression in Oxidative Stress and Inflammation Through Activation of Nrf2 Signaling Pathway in Rats. Arsenic Trioxide 34-50 NFE2 like bZIP transcription factor 2 Rattus norvegicus 161-165 27713174-9 2017 In conclusion, our results suggested that oxymatrine protected against As2O3-induced oxidative damage by activating Nrf2/HO-1 signaling pathway. Arsenic Trioxide 71-76 NFE2 like bZIP transcription factor 2 Rattus norvegicus 116-120 27980225-0 2017 Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway. Arsenic Trioxide 27-43 NFE2 like bZIP transcription factor 2 Rattus norvegicus 88-92 27980225-10 2017 In conclusion, our results indicated that melatonin protected against As2O3-induced liver injury by inducing Nrf2/HO-1 expression via upregulation of PI3K/AKT pathway. Arsenic Trioxide 70-75 NFE2 like bZIP transcription factor 2 Rattus norvegicus 109-113 26775255-0 2016 Taurine protects against As2O3-induced autophagy in pancreas of rat offsprings through Nrf2/Trx pathway. Arsenic Trioxide 25-30 NFE2 like bZIP transcription factor 2 Rattus norvegicus 87-91 27608960-8 2016 Moreover, imperatorin and sec-O-glucosylhamaudol triggered Nrf2 activation, which resulted in upregulation of downstream phase II metabolic enzymes and antioxidant protein/enzyme, probably offering cellular protection to As2O3-induced cardiotoxicity via the Nrf2 signal pathway. Arsenic Trioxide 221-226 NFE2 like bZIP transcription factor 2 Rattus norvegicus 59-63 27608960-8 2016 Moreover, imperatorin and sec-O-glucosylhamaudol triggered Nrf2 activation, which resulted in upregulation of downstream phase II metabolic enzymes and antioxidant protein/enzyme, probably offering cellular protection to As2O3-induced cardiotoxicity via the Nrf2 signal pathway. Arsenic Trioxide 221-226 NFE2 like bZIP transcription factor 2 Rattus norvegicus 258-262 26775255-3 2016 Since NF-E2-related factor 2 (Nrf2) and the thioredoxin (Trx) system was a crucial line of defense against ROS, we investigated whether Nrf2/Trx pathway contributed to As2O3-stimulated autophagy and the role of taurine in this study. Arsenic Trioxide 168-173 NFE2 like bZIP transcription factor 2 Rattus norvegicus 136-140 26775255-4 2016 After treatment with 2 mg/kg BW-8 mg/kg BW As2O3 for 57 d, the expression of Nrf2 protein was decreased significantly in offsprings" pancreas. Arsenic Trioxide 43-48 NFE2 like bZIP transcription factor 2 Rattus norvegicus 77-81