PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24328305-0	2014	Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.	n-glycans	52-61	serpin family A member 1	Homo sapiens	73-92	
26316330-5	2016	In this study, we further determined the theoretical numbers of glycoprotein species of two recombinant glycoproteins - a therapeutical antibody and the human protease inhibitor alpha-1-antitrypsin (A1AT) - based on structural analysis of their N-glycans.	n-glycans	245-254	serpin family A member 1	Homo sapiens	178-197	
24328305-11	2014	This study has identified increased fucosylation on N-glycans of Z-AAT indicative of ongoing inflammation in AATD individuals with implications for early therapeutic intervention.	n-glycans	52-61	serpin family A member 1	Homo sapiens	67-70	
32958677-7	2020	Also, N-glycans attached to misfolded AAT are not required for accelerated degradation mediated by the unconventional system, further demonstrating its catalysis-independent nature.	n-glycans	6-15	serpin family A member 1	Homo sapiens	38-41	
30513349-4	2019	Recombinantly produced A1AT and C1INH (rhA1AT, rhC1INH) decorated with humanized N-glycans are therefore of clinical and commercial interest.	n-glycans	81-90	serpin family A member 1	Homo sapiens	23-27	
24566669-8	2014	Abnormal hybrid type N-glycans were also observed in the glycoprofiles of total serum proteins, of enriched immunoglobulins and of alpha1-antitrypsin in variable amounts.	n-glycans	21-30	serpin family A member 1	Homo sapiens	131-149	
24328305-0	2014	Increased outer arm and core fucose residues on the N-glycans of mutated alpha-1 antitrypsin protein from alpha-1 antitrypsin deficient individuals.	n-glycans	52-61	serpin family A member 1	Homo sapiens	106-125	
16622833-2	2006	The three N-glycosylation sites of A1PI contain diantennary N-glycans but also triantennary and even traces of tetraantennary structures leading to the typical IEF pattern observed for A1PI.	n-glycans	60-69	serpin family A member 1	Homo sapiens	35-39	
23668542-4	2013	Because of the supplementary N-glycans, the A1AT variants exhibited an increased molecular weight.	n-glycans	29-38	serpin family A member 1	Homo sapiens	44-48	
23668542-6	2013	The A1AT variants were treated with PNGase F, and the resulting N-glycans were analyzed by MALDI-TOF mass spectrometry.	n-glycans	64-73	serpin family A member 1	Homo sapiens	4-8	
23668542-7	2013	The N-glycan profile of the recombinant A1AT variants was mostly composed of monofucosylated bi-, tri-, and tetraantennary complex-type N-glycans, with a tendency toward higher antennary structures compared to the wild-type.	n-glycans	136-145	serpin family A member 1	Homo sapiens	40-44	
17727818-3	2007	Here we demonstrate that overexpression of Golgi alpha1,2-mannosidase IA, IB, and IC also accelerates ERAD of terminally misfolded human alpha1-antitrypsin variant null (Hong Kong) (NHK), and mannose trimming from the N-glycans on NHK in 293 cells.	n-glycans	218-227	serpin family A member 1	Homo sapiens	137-155	
35137040-5	2022	The N-glycan analysis of the serum proteome further revealed that relative intensities of IgG-specific complex type di-antennary N-glycans with core-fucosylation were considerably reduced in the patient"s serum whereas TF- and AAT-characteristic sialylated di- and tri-antennary N-glycans were increased.	n-glycans	129-138	serpin family A member 1	Homo sapiens	227-230	
35508753-8	2022	Using the CR5 promoter, glycoengineered stable CHO pools were able to produce over 2.1 g/L and 2.8 g/L of wild-type and mutein forms of A1AT, respectively, with N-glycans analogous to the plasma-derived clinical product Prolastin-C. Supplementation of N-acetylmannosamine to the cell culture media during production increased the overall sialylation of A1AT as well as the proportion of bi-antennary and disialylated A2G2S2 N-glycans.	n-glycans	424-433	serpin family A member 1	Homo sapiens	136-140	
8563136-5	1995	CDGS alpha-1AT isoforms bore N-glycans co-migrating with monosialylated standards, while normal alpha-1AT oligosaccharides co-migrated with both mono- and disialylated standards.	n-glycans	29-38	serpin family A member 1	Homo sapiens	5-14	
35508753-8	2022	Using the CR5 promoter, glycoengineered stable CHO pools were able to produce over 2.1 g/L and 2.8 g/L of wild-type and mutein forms of A1AT, respectively, with N-glycans analogous to the plasma-derived clinical product Prolastin-C. Supplementation of N-acetylmannosamine to the cell culture media during production increased the overall sialylation of A1AT as well as the proportion of bi-antennary and disialylated A2G2S2 N-glycans.	n-glycans	161-170	serpin family A member 1	Homo sapiens	136-140	
35137040-5	2022	The N-glycan analysis of the serum proteome further revealed that relative intensities of IgG-specific complex type di-antennary N-glycans with core-fucosylation were considerably reduced in the patient"s serum whereas TF- and AAT-characteristic sialylated di- and tri-antennary N-glycans were increased.	n-glycans	279-288	serpin family A member 1	Homo sapiens	227-230