PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15781526-7	2005	Bupivacaine prevented this inflammatory response: 992 +/- 102 versus 2146 +/- 338 versus 919 +/- 116 pg/mL for TNF-alpha (bupivacaine + carrageenan versus carrageenan versus control after LPS stimulation).	Bupivacaine	0-11	tumor necrosis factor	Mus musculus	111-120	
15781526-7	2005	Bupivacaine prevented this inflammatory response: 992 +/- 102 versus 2146 +/- 338 versus 919 +/- 116 pg/mL for TNF-alpha (bupivacaine + carrageenan versus carrageenan versus control after LPS stimulation).	Bupivacaine	122-133	tumor necrosis factor	Mus musculus	111-120	
29802833-0	2018	TNF-alpha and TNF-R1 regulate bupivacaine-induced apoptosis in spinal cord dorsal root ganglion neuron.	Bupivacaine	30-41	tumor necrosis factor	Mus musculus	0-9	
29802833-2	2018	This study used an in vitro model to explore the expression and function of tumor necrosis factor (TNF) signaling pathway in bupivacaine-induced apoptotic injury in spinal cord dorsal root ganglia (DRG).	Bupivacaine	125-136	tumor necrosis factor	Mus musculus	76-97	
29802833-2	2018	This study used an in vitro model to explore the expression and function of tumor necrosis factor (TNF) signaling pathway in bupivacaine-induced apoptotic injury in spinal cord dorsal root ganglia (DRG).	Bupivacaine	125-136	tumor necrosis factor	Mus musculus	99-102	
29802833-4	2018	QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG.	Bupivacaine	43-54	tumor necrosis factor	Mus musculus	67-76	
29802833-4	2018	QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG.	Bupivacaine	43-54	tumor necrosis factor	Mus musculus	78-87	
29802833-4	2018	QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG.	Bupivacaine	43-54	tumor necrosis factor	Mus musculus	67-70	
29802833-4	2018	QRT-PCR and western blot demonstrated that bupivacaine upregulated TNF-alpha (TNF-alpha) and TNF receptor 1 (TNF-R1), but left TNF receptor 2 (TNF-R2) unaffected in DRG.	Bupivacaine	43-54	tumor necrosis factor	Mus musculus	78-81	
29802833-5	2018	SiRNA-mediated TNF-alpha or TNF-R1 inhibition, but not TNF-R2 inhibition, rescued bupivacaine-induced DRG apoptosis.	Bupivacaine	82-93	tumor necrosis factor	Mus musculus	15-24	
29802833-6	2018	In addition, qRT-PCR and western blot demonstrated that downstream substrates of apoptotic and TNF signaling pathways, caspase-9, MAP3K and JNK, were all significantly downregulated by TNF-alpha or TNF-R1 inhibition, but not by TNF-R2 inhibition, in bupivacaine-injured DRG.	Bupivacaine	250-261	tumor necrosis factor	Mus musculus	95-98	
29802833-6	2018	In addition, qRT-PCR and western blot demonstrated that downstream substrates of apoptotic and TNF signaling pathways, caspase-9, MAP3K and JNK, were all significantly downregulated by TNF-alpha or TNF-R1 inhibition, but not by TNF-R2 inhibition, in bupivacaine-injured DRG.	Bupivacaine	250-261	tumor necrosis factor	Mus musculus	185-194	
18339158-10	2008	In a dose-dependent manner, bupivacaine also significantly inhibited the effects of LPS on the production of TNF-alpha, IL-1beta, and IL-6.	Bupivacaine	28-39	tumor necrosis factor	Mus musculus	109-118