PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
28450945-11	2017	Furthermore, reverse transcription-quantitative polymerase chain reaction analysis was performed to analyze the expression levels of inflammatory cytokines, which demonstrated that bupivacaine significantly inhibited the expression of TNF-alpha, IL-1beta and IL-6, as compared with the untreated group (P<0.01).	Bupivacaine	181-192	interleukin 1 beta	Rattus norvegicus	246-254	
16810004-9	2006	Bupivacaine was effective in suppressing systemic tumor necrosis factor alpha and interleukin 1beta by all three routes, whereas tetrodotoxin was ineffective by all three routes.	Bupivacaine	0-11	interleukin 1 beta	Rattus norvegicus	82-99	
24083665-3	2013	We investigated whether bupivacaine exerts an influence on the Ca(2+) signaling and interleukin-1beta (IL-1beta) secretion in inflammation-reactive astrocytes when used at ultralow concentrations, < 10(-8)  m. Furthermore, we wanted to determine if bupivacaine interacts with the opioid-, 5-hydroxytryptamine- (5-HT) and glutamate-receptor systems.	Bupivacaine	24-35	interleukin 1 beta	Rattus norvegicus	84-101	
24083665-6	2013	Ultralow concentrations of bupivacaine attenuated the inflammation-induced upregulation of IL-1beta secretion.	Bupivacaine	27-38	interleukin 1 beta	Rattus norvegicus	91-99	
24083665-7	2013	The results indicate that bupivacaine interacts with the opioid-, 5-HT- and glutamate-receptor systems by affecting Ca(2+) signaling and IL-1beta release in inflammation-reactive astrocytes.	Bupivacaine	26-37	interleukin 1 beta	Rattus norvegicus	137-145	
24120988-2	2013	We focused on whether naloxone, ouabain, and bupivacaine, all agents with reported anti-inflammatory effects on astrocytes, could affect the release of TNF-alpha and IL-1beta in microglia.	Bupivacaine	45-56	interleukin 1 beta	Rattus norvegicus	166-174