PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22233781-11	2012	More importantly, pharmacological inhibition of Akt and ERK diminished the protective effect of lithium against bupivacaine-induced neuronal death.	Bupivacaine	112-123	thymoma viral proto-oncogene 1	Mus musculus	48-51	
30651766-0	2019	HIF-alpha/PKM2 and PI3K-AKT pathways involved in the protection by dexmedetomidine against isoflurane or bupivacaine-induced apoptosis in hippocampal neuronal HT22 cells.	Bupivacaine	105-116	thymoma viral proto-oncogene 1	Mus musculus	24-27	
34652691-0	2021	MiRNA-494-3p Regulates Bupivacaine-Induced Neurotoxicity by the CDK6-PI3K/AKT Signaling.	Bupivacaine	23-34	thymoma viral proto-oncogene 1	Mus musculus	74-77	
34652691-12	2021	MiR-494-3p depletion also activated PI3K/AKT signaling by elevating CDK6 expression in BUP-treated neurons.	Bupivacaine	87-90	thymoma viral proto-oncogene 1	Mus musculus	41-44	
20038443-13	2010	Importantly, pharmacological inhibition of Akt abolished the protective effect of dexamethasone against bupivacaine-induced cell injury.	Bupivacaine	104-115	thymoma viral proto-oncogene 1	Mus musculus	43-46	
20228829-0	2010	Bupivacaine causes cytotoxicity in mouse C2C12 myoblast cells: involvement of ERK and Akt signaling pathways.	Bupivacaine	0-11	thymoma viral proto-oncogene 1	Mus musculus	86-89	
19879292-0	2010	Alpha-lipoic acid prevents bupivacaine-induced neuron injury in vitro through a PI3K/Akt-dependent mechanism.	Bupivacaine	27-38	thymoma viral proto-oncogene 1	Mus musculus	85-88	
19879292-8	2010	In a separate experiment, we determined the effect of Akt inhibition on cell viability in the presence of LA and bupivacaine.	Bupivacaine	113-124	thymoma viral proto-oncogene 1	Mus musculus	54-57	
19879292-12	2010	More significantly, pharmacological inhibition of Akt abolished the LA-induced protection from bupivacaine-caused cell injury.	Bupivacaine	95-106	thymoma viral proto-oncogene 1	Mus musculus	50-53