PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26161242-0 2015 OGG1 Involvement in High Glucose-Mediated Enhancement of Bupivacaine-Induced Oxidative DNA Damage in SH-SY5Y Cells. Bupivacaine 57-68 8-oxoguanine DNA glycosylase Homo sapiens 0-4 26161242-7 2015 OGG1 expression was inhibited in cells exposed to high glucose with concomitant increase in ROS production and more severe DNA damage as compared to control culture conditions, and these changes were further exacerbated by bupivacaine. Bupivacaine 223-234 8-oxoguanine DNA glycosylase Homo sapiens 0-4 26161242-8 2015 Treatment with the antioxidant N-acetyl-L-cysteine (NAC) prevented high glucose and bupivacaine mediated increase in ROS production and restored functional expression of OGG1, which lead to attenuated high glucose-mediated exacerbation of bupivacaine neurotoxicity. Bupivacaine 239-250 8-oxoguanine DNA glycosylase Homo sapiens 170-174