PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24605337-5	2014	We have accordingly attempted to relate the growth inhibitory effects of bupivacaine with the status of S6K1 activity and we present evidence that decrease in cell growth and proliferation by bupivacaine is mediated through inactivation of S6 kinase 1 in a concentration and time dependent manner.	Bupivacaine	192-203	ribosomal protein S6 kinase B1	Homo sapiens	104-108	
31180558-9	2019	Additionally, bupivacaine inhibited protein kinase B (Akt)/mammalian target of rapamycin (mTOR)/S6 kinase (S6K) signaling, which is a negative regulator of autophagic activity.	Bupivacaine	14-25	ribosomal protein S6 kinase B1	Homo sapiens	107-110	
31180558-11	2019	The findings indicated that application of clinically relevant concentrations of bupivacaine upregulated autophagic activity via inhibition of Akt/mTOR/S6K signaling.	Bupivacaine	81-92	ribosomal protein S6 kinase B1	Homo sapiens	152-155