PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
17620218-7	2007	These results suggest that CYP2B6 has an important role in propofol omega- and 4-hydroxylation in human livers and that the hepatic contents of CYP2B6, CYP3A4, and CYP1A2 determine which P450 enzymes play major roles in propofol oxidation in individual humans.	Propofol	220-228	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-158	
12708606-0	2003	The effect of propofol (anesthetic and inhibitor of CYP3A4) on serum lidocaine concentrations in smokers and chronic alcohol consumers.	Propofol	14-22	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	52-58	
17620218-2	2007	Of six cDNA-expressed human P450 enzymes tested, CYP2B6 and CYP1A2, followed by CYP3A4, had high catalytic activities at a 20 microM propofol concentration, corresponding to clinical plasma levels.	Propofol	133-141	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-86	
17620218-5	2007	In a panel of individual human liver microsomes, propofol omega- and 4-hydroxylation activities (at the substrate concentration of 20 microM) were highly correlated with CYP2B6 contents, and moderately with CYP3A4 contents.	Propofol	49-57	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	207-213	
16421682-10	2006	Propofol shows a competitive inhibitory effect on the metabolism of ropivacaine (i.e., PPX production mediated by CYP3A4) in human CYP systems in vitro.	Propofol	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	114-120	
12970884-0	2003	Potential inhibition of cytochrome P450 3A4 by propofol in human primary hepatocytes.	Propofol	47-55	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	24-43	
12970884-9	2003	RESULTS: A dose-dependent inhibitory effect of propofol was observed in cytochrome P450 3A4 activity.	Propofol	47-55	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-91	
12970884-11	2003	CONCLUSION: Propofol may be a potential CYP3A4 inhibitor as this anesthetic can inhibit isoenzyme activity significantly and reduce the metabolic rate of CYP3A4 substrates.	Propofol	12-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46	
12970884-11	2003	CONCLUSION: Propofol may be a potential CYP3A4 inhibitor as this anesthetic can inhibit isoenzyme activity significantly and reduce the metabolic rate of CYP3A4 substrates.	Propofol	12-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	154-160	
12970884-13	2003	propofol may thus induce drug interaction of cytochrome P450 3A4 activity at the dosage used clinically.	Propofol	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-64	
15058585-10	2004	Propofol competitively inhibited the metabolism of midazolam to 1"-hydroxymidazolam by CYP3A4.	Propofol	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	87-93	
10455828-0	1999	The effect of oxygen on propofol-induced inhibition of microsomal cytochrome P450 3A4.	Propofol	24-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-85	
10460064-0	1999	Propofol decreases the clearance of midazolam by inhibiting CYP3A4: an in vivo and in vitro study.	Propofol	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	60-66	
10460064-1	1999	OBJECTIVE: To examine the effect of propofol on the pharmacokinetics of midazolam in vivo and to elucidate the mechanism of the pharmacokinetic changes of midazolam by propofol with the use of human liver microsomes and recombinant CYP3A4.	Propofol	168-176	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	232-238	
10460064-5	1999	In an in vitro study the effect of propofol on the metabolism of midazolam was studied with human liver microsomes and recombinant CYP3A4.	Propofol	35-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	131-137	
10460064-11	1999	CONCLUSION: Propofol decreases the clearance of midazolam, and the possible mechanism is the competitive inhibition of hepatic CYP3A4.	Propofol	12-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-133	
12234619-2	2002	To determine whether 2,6-diisopropylphenol (propofol), a widely used intravenous anesthetic agent, known to inhibit CYP3A4 and CYP1A2, also inhibits CYP2E1, 6-OH hydroxylation of chlorzoxazone, a prototypical CYP2E1 substrate, was estimated using two pools of human microsomes and one pool of porcine microsomes from seven livers.	Propofol	21-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	116-122	
12234619-2	2002	To determine whether 2,6-diisopropylphenol (propofol), a widely used intravenous anesthetic agent, known to inhibit CYP3A4 and CYP1A2, also inhibits CYP2E1, 6-OH hydroxylation of chlorzoxazone, a prototypical CYP2E1 substrate, was estimated using two pools of human microsomes and one pool of porcine microsomes from seven livers.	Propofol	44-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	116-122	
9764927-3	1998	Propofol produced inhibition of CYP1A2 (phenacetin O-deethylation), CYP2C9 (tolbutamide 4"-hydroxylation), CYP2D6 (dextromethorphan O-demethylation) and CYP3A4 (testosterone 6beta-hydroxylation) activities with IC50 = 40, 49, 213 and 32 microM respectively.	Propofol	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	153-159