PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
29800814-0	2018	Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFalpha signaling.	piperine	0-8	CREB regulated transcription coactivator 1	Mus musculus	53-59	
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	piperine	33-41	CREB regulated transcription coactivator 1	Mus musculus	269-275	
29800814-4	2018	The objective of the study was to determine whether curcumin and piperine have individual and combined effects in the setting of gut inflammation by regulating mTORC1 in human intestinal epithelial cells.	piperine	65-73	CREB regulated transcription coactivator 1	Mus musculus	160-166	
29800814-6	2018	Piperine inhibited mTORC1 activity albeit at comparatively higher concentrations than curcumin.	piperine	0-8	CREB regulated transcription coactivator 1	Mus musculus	19-25	
29800814-7	2018	The combination of curcumin + piperine further repressed mTORC1 signaling (P<.02).	piperine	30-38	CREB regulated transcription coactivator 1	Mus musculus	57-63	
29800814-12	2018	We conclude that curcumin and piperine, either alone or in combination, have the potential to down-regulate mTORC1 signaling in the intestinal epithelium with implications for tumorigenesis and inflammation.	piperine	30-38	CREB regulated transcription coactivator 1	Mus musculus	108-114	
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	piperine	33-41	CREB regulated transcription coactivator 1	Mus musculus	78-84	
27572322-8	2016	In addition, PIP induced autophagy by inhibiting mammalian target of rapamycin complex 1(mTORC1) via activation of protein phosphotase 2A (PP2A).	piperine	13-16	CREB regulated transcription coactivator 1	Mus musculus	89-95	
26439699-4	2015	Here we report that piperine robustly boosts mTORC1 activity by recruiting more system L1 amino acid transporter (SLC7A5/SLC3A2) to the cell membrane, thus promoting amino acid metabolism.	piperine	20-28	CREB regulated transcription coactivator 1	Mus musculus	45-51	
26439699-5	2015	Piperine-induced increase of mTORC1 activity in resident peritoneal macrophages (pMPhis) is correlated with enhanced production of IL-6 and TNF-alpha upon LPS stimulation.	piperine	0-8	CREB regulated transcription coactivator 1	Mus musculus	29-35