PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33835632-6	2021	In the carbon tetrachloride (CCl4 ) fibrosis-induced rat model, GM improved histological damage, inhibited the activity of hepatic alpha-smooth muscle actin (alpha-SMA), and improved serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in a dose-dependent manner.	Carbon Tetrachloride	7-27	actin gamma 2, smooth muscle	Rattus norvegicus	131-156	
32724654-3	2020	MF also suppressed the increase in type l collagen and alpha-smooth muscle actin expression in the livers of ethanol plus CCl4-induced rat by the maintenance of intracellular glutathione levels.	Carbon Tetrachloride	122-126	actin gamma 2, smooth muscle	Rattus norvegicus	55-80	
30098497-5	2018	Our results indicated that treatment with OCT markedly down-regulated the protein and mRNA expression of liver fibrosis markers including alpha-smooth muscle actin (alpha-SMA) and collagen I in CCl4-induced rat model of liver fibrosis, accompanied by decreasing aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL) activities and increasing the serum level of albumin (ALB).	Carbon Tetrachloride	194-198	actin gamma 2, smooth muscle	Rattus norvegicus	138-163	
31258681-3	2019	In a carbon tetrachloride (CCl4)-treated rat model, fibrogenesis-associated indexes, including hydroxyproline content, collagen deposition, and alpha-smooth muscle actin (alpha-SMA) and albumin expression, were examined in in vivo and in vitro models.	Carbon Tetrachloride	5-25	actin gamma 2, smooth muscle	Rattus norvegicus	171-180	
30119204-5	2018	Among the liver fibrosis indicators, alpha-smooth muscle actin (alpha-SMA) was decreased by YGL in the CCl4-treated rats, while MMP2 and MMP9 was upregulated followed by TIMP1 downregulation.	Carbon Tetrachloride	103-107	actin gamma 2, smooth muscle	Rattus norvegicus	37-62	
30119204-5	2018	Among the liver fibrosis indicators, alpha-smooth muscle actin (alpha-SMA) was decreased by YGL in the CCl4-treated rats, while MMP2 and MMP9 was upregulated followed by TIMP1 downregulation.	Carbon Tetrachloride	103-107	actin gamma 2, smooth muscle	Rattus norvegicus	64-73	
27069546-4	2016	We analyzed the CTGF gene promoter methylation inHSCs that undergo a phenotypic change into myofibroblast-like cellsthat express alpha-smooth muscle actin (alpha-SMA) in vitro and in vivo in a CCl4-induced rat hepatic fibrosis model.	Carbon Tetrachloride	193-197	actin gamma 2, smooth muscle	Rattus norvegicus	156-165	
26573209-8	2016	NIM811 profoundly inhibited collagen I, alpha-SMA, TGF-beta1 and TbetaR-I expression in the liver of CCl4-treated rats.	Carbon Tetrachloride	101-105	actin gamma 2, smooth muscle	Rattus norvegicus	40-49	
19422480-8	2009	Infusion of HMSCs significantly inhibited TGF-beta1, collagen type I and alpha-SMA expressions in CCl4-induced cirrhotic rats.	Carbon Tetrachloride	98-102	actin gamma 2, smooth muscle	Rattus norvegicus	73-82	
16941698-4	2006	Immunohistochemical analysis of liver sections obtained from rats with CCl4-induced cirrhosis revealed increased expression and colocalization of ILK and alpha-smooth muscle actin in hepatic stellate cells in perisinusoidal areas.	Carbon Tetrachloride	71-75	actin gamma 2, smooth muscle	Rattus norvegicus	154-179