PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
30132521-0	2018	Downregulation of Glt25d1 aggravates carbon tetrachloride-induced acute hepatic injury through activation of the TGF-beta1/Smad2 signaling pathway.	Carbon Tetrachloride	37-57	SMAD family member 2	Mus musculus	123-128	
29490978-5	2018	Transient increases in TGF-beta1 levels and Smad2 phosphorylation signaling were observed 6 hours and 3 days, respectively, after CCl4 challenge in WT, but not PF4CreTgfb1f/f , mice, suggesting that increased TGF-beta1 levels originated from platelet-released TGF-beta1 during the initial injury.	Carbon Tetrachloride	130-134	SMAD family member 2	Mus musculus	44-49	
27186319-10	2016	Smad 2/3, the major mediator of TGF-beta fibrogenic effects, was also activated after CCl4 treatment.	Carbon Tetrachloride	86-90	SMAD family member 2	Mus musculus	0-8	
35387552-9	2022	Moreover, GZFL downregulated the expressions of TGF-beta1, p-Smad2, p-Smad3, and CUGBP1 in CCl4-treated mice.	Carbon Tetrachloride	91-95	SMAD family member 2	Mus musculus	61-66	
27562139-5	2016	CCl4 intoxication-induced hepatic stellate cell activation was inhibited by the vaccination, as indicated by decreased alpha-smooth muscle actin expression and Smad2 phosphorylation.	Carbon Tetrachloride	0-4	SMAD family member 2	Mus musculus	160-165	
35240537-4	2022	Furthermore, CCl4-triggerd collagen deposition and liver fibrosis were remarkably attenuated in mice with Mul supplementation through suppressing transforming growth factor beta1 (TGF-beta1)/SMAD2/3 signaling pathway.	Carbon Tetrachloride	13-17	SMAD family member 2	Mus musculus	191-198	
32783983-0	2020	Baihe Wuyao decoction ameliorates CCl4-induced chronic liver injury and liver fibrosis in mice through blocking TGF-beta1/Smad2/3 signaling, anti-inflammation and anti-oxidation effects.	Carbon Tetrachloride	34-38	SMAD family member 2	Mus musculus	122-129	
32783983-16	2020	CONCLUSION: BWD ameliorates CCl4-induced CLI and liver fibrosis which is correlated to its blocking TGF-beta1/Smad2/3 signaling, anti-inflammation, and anti-oxidation effects.	Carbon Tetrachloride	28-32	SMAD family member 2	Mus musculus	110-117